東北大学研究者紹介

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オカモト　コウジ

岡本　好司

Koji Okamoto

所属

大学院医学系研究科　医科学専攻　内科病態学講座（腎臓内科学分野）

職名

准教授

学位

PhD （東京大学）

researchmap

https://researchmap.jp/k5okamoto

J-GLOBAL ID

201801011370876967

e-Rad 研究者番号

80572247

経歴 12

2026年4月～継続中

東北大学　腎臓・高血圧内科　准教授
2021年4月～ 2025年3月

東北大学　腎臓・高血圧内科　講師
2019年4月～ 2021年3月

東北メディカル・メガバンク機構　東北メディカル・メガバンク機構　助教
2018年10月～ 2019年3月

東北大学病院　腎・高血圧・内分泌科　助教
2012年4月～ 2018年3月

米国国立衛生研究所　腎臓分野　客員研究員
2012年6月～ 2014年5月

学術振興会　海外特別研究員
2011年4月～ 2012年3月

東大病院　腎臓内分泌内科　助教
2009年4月～ 2010年3月

東大病院　腎臓内分泌内科　医員
2003年4月～ 2005年3月

湘南鎌倉総合病院　腎臓内科　後期研修医
2002年4月～ 2003年3月

日本赤十字社医療センター　内科　内科研修医
2001年4月～ 2002年3月

東大病院　内科　内科研修医
2022年4月～

東北大学病院　血液浄化療法部　副部長

︎全件表示 ︎最初の5件までを表示

学歴 2

東京大学　医学系研究科　内科学

2005年4月～ 2009年3月
東北大　医学部　医学科

1995年4月～ 2001年3月

所属学協会 3

日本人類遺伝学会
日本透析医学会
日本腎臓学会

研究キーワード 6

動脈硬化症
疾患感受性遺伝子
HIV関連腎症
糖尿病性腎症
RNA高次構造
ネフローゼ症候群

研究分野 4

ライフサイエンス / ウイルス学 / 後天性免疫不全症候群
ライフサイエンス / 医化学 / 疾患感受性遺伝子
ライフサイエンス / 代謝、内分泌学 / 糖尿病
ライフサイエンス / 腎臓内科学 / 糸球体疾患

受賞 3

優秀論文賞

2021年6月　日本腎臓学会
23rd Annual Fellows Research Forum Award

2014年6月　National Kidney Foundation
CKDアウォード2011

2011年11月　ベーリンガーインゲルハイム　糖尿病性腎症におけるFGF2-GPC5 経路の意義と治療ターゲットとしての可能性

論文 83

Predicting Lifetime Risk of Kidney Failure Using Age and a Single eGFR Measurement. 国際誌

Ryo Enoki, Mariko Miyazaki, Enyu Imai, Tetsuhiro Tanaka, Koji Okamoto

Journal of clinical medicine　15　(7)　2026年3月31日

DOI： 10.3390/jcm15072653 　

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Background: The prognosis of chronic kidney disease (CKD) typically requires longitudinal estimated glomerular filtration rate (eGFR) data, making risk stratification difficult at initial consultation. Furthermore, eGFR-based clinical decisions often overlook the critical factor of patient age. This study aimed to establish a simplified predictive model for progressive CKD and quantify the impact of clinical interventions. Methods: Utilizing a historical dataset (1988-2003) from the pre-renin-angiotensin system inhibitor (RASi) and pre-sodium-glucose cotransporter 2 inhibitor (SGLT2i) era, we developed heatmaps to predict the probability of reaching eGFR < 30 mL/min/1.73 m2 by age 80 years. The model also estimated the risk reduction from smoking cessation and pharmacological therapies. The predictive performance for age + eGFR was assessed using standard calibration and discrimination metrics, and clinical utility was evaluated using decision curve analysis across a range of threshold probabilities. Risk reclassification analyses compared age +eGFR-based categories with conventional eGFR-based stratification. Results: Regarding the risk of eGFR < 30 mL/min/1.73 m2 by age 80 years, simulations confirmed a correlation between age and eGFR. At age 40 years, an eGFR of ~57 mL/min/1.73 m2 indicated a 50% probability of progressing to CKD stage 4 by age 80 years. This threshold decreases to 53 and 48 mL/min/1.73 m2 at 50 and 60 years of age, respectively. Calibration and discrimination analyses demonstrated acceptable agreement between predicted and observed risks. Decision curve analysis showed that an age + eGFR threshold of approximately 115 primarily provided a net benefit at lower threshold probabilities, supporting intensified surveillance strategies, whereas an age +eGFR of 100 showed a positive net benefit across a broader range of thresholds, comparable to the conventional eGFR < 45 mL/min/1.73 m2 criterion. While proteinuria markedly increased risk, smoking cessation provided a 9.4-11.2% risk reduction. Combined RASi and SGLT2i treatment showed the greatest impact, reducing progression probability by 31.2-40.0% (e.g., reducing a 50.0% baseline risk to 32.1% in 40-year-old men). Conclusions: The age + eGFR rule represents a simple, clinically interpretable heuristic for age-adjusted risk stratification based on a single eGFR measurement and may offer potential clinical utility for guiding surveillance intensity and consideration of earlier intervention strategies. However, external validation is required before clinical application.
Novel clinical application of urinary angiotensin-converting enzyme assay in renal sarcoidosis: a retrospective observational study.

Yuki Chiba, Koji Murakami, Mariko Miyazaki, Rui Makino, Mai Yoshida, Tasuku Nagasawa, Hiroshi Sato, Tsutomu Tamada, Tetsuhiro Tanaka, Koji Okamoto

Clinical and experimental nephrology　2026年2月3日

DOI： 10.1007/s10157-025-02803-8 　

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BACKGROUND: Renal involvement, occurring in approximately -1% to 5% of patients with sarcoidosis, is characterized mainly by granulomatous interstitial nephritis. Angiotensin-converting enzyme (ACE) reflects the presence of granuloma; accordingly, serum ACE (sACE) and tubular injury markers are measured in renal sarcoidosis (RS). However, these markers possess low diagnostic accuracy; therefore, we hypothesized that urinary ACE (uACE) could reflect granuloma in the kidneys and be a disease-specific marker for RS. METHODS: In this single-center retrospective study, the sACE and uACE levels were measured and the creatinine-corrected ratio of uACE and sACE (u/s ACE ratio) was calculated. Additionally, patients with sarcoidosis without renal insufficiency (RI), sarcoidosis with RI, and tubulointerstitial nephritis (TIN) without a sarcoidosis etiology were included as controls. RESULTS: This study included 18, 18, 14, and 10 patients in the RS, sarcoidosis without RI, sarcoidosis with RI, and TIN without sarcoidosis etiology groups, respectively. uACE and u/s ACE ratio in the RS group were higher than those in the control groups. In the RS group, u/s ACE ratio was positively correlated with the degree of tubulointerstitial injury (r = 0.69, P = 0.0045); the cutoff value of u/s ACE ratio for diffuse tubulointerstitial injury was 0.39%, with a sensitivity and specificity of 100.0% each. Furthermore, obvious positive correlations were observed among u/s ACE ratio, inflammatory cell infiltrates (r = 0.53, P = 0.044), and interstitial fibrosis (r = 0.56, P = 0.029) in the RS group. CONCLUSION: u/s ACE ratio and sACE could be useful biomarkers for diagnosing RS in sarcoidosis and TIN, respectively. A simple uACE assay could help diagnose and assess disease severity in patients with RS.
A case of malignant hypertension due to sarcoidosis. 国際誌

Sosuke Kinomura, Takafumi Toyohara, Yuki Chiba, Hidekazu Aoki, Yusuke Ishizuka, Yuji Noguchi, Saori Kin, Maho Akiu, Koichi Kikuchi, Rui Makino, Mai Yoshida, Yuji Oe, Tasuku Nagasawa, Koji Okamoto, Mariko Miyazaki, Hiroshi Sato, Kei Takase, Takaaki Abe, Tetsuhiro Tanaka

Journal of hypertension　43　(10)　1721-1725　2025年10月1日

DOI： 10.1097/HJH.0000000000004110 　

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Sarcoidosis is a systemic inflammatory disease that is difficult to diagnose. This report describes a 54-year-old man who presented with an incidental finding of abnormal hilar shadows on imaging, indicating sarcoidosis. During follow-up, he experienced a sudden blood pressure increase (210/140 mmHg) accompanied by headaches, nausea, hypertensive retinopathy, and renal dysfunction, diagnosed as malignant hypertension. Contrast-enhanced computed tomography (CT) revealed wedge-shaped areas of poor enhancement in both kidneys, suggesting impaired perfusion due to interlobar artery compression. Renal biopsy showed noncaseating epithelioid cell granulomas, confirming renal sarcoidosis. After prednisolone treatment, the active renin concentration decreased from 265 pg/ml to 89 pg/ml, and the renal perfusion abnormalities improved on repeat CT. Renovascular hypertension due to sarcoidosis nodules disrupting the interlobar artery strongly suggests the cause of malignant hypertension. This is the first reported case of malignant hypertension due to renal sarcoidosis. Therefore, sarcoidosis should be considered as a differential diagnosis in patients with malignant hypertension.
FSGSを呈し,COL4A4変異を認めた成人発症難治性ネフローゼの一例

梶原佳子, 豊原敬文, 榎亮, 中里彰彦, 渡邉駿, 菊地晃一, 吉田舞, 牧野塁, 大江佑治, 岡本好司, 長澤将, 森崇寧, 蘇原映誠, 内田信一, 佐藤博, 宮崎真理子, 田中哲洋

日本腎臓学会誌　67　(6-E)　827-827　2025年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
甲状腺癌術後の維持透析患者に対してRI療法を施行した1例

葛西良, 柴田浩明, 鈴木雄太, 庄内千紘, 家入珠樹, 秋保真穂, 岡本好司, 宮崎真理子, 石垣麻衣, 児玉裕康, 臼崎琢磨, 神宮啓一

日本透析医学会雑誌　58　(Suppl.1)　1011-1011　2025年5月
出版者・発行元： (一社)日本透析医学会
ISSN：1340-3451

eISSN：1883-082X
甲状腺癌術後の維持透析患者に対してRI療法を施行した1例

葛西良, 柴田浩明, 鈴木雄太, 庄内千紘, 家入珠樹, 秋保真穂, 岡本好司, 宮崎真理子, 石垣麻衣, 児玉裕康, 臼崎琢磨, 神宮啓一

日本透析医学会雑誌　58　(Suppl.1)　1011-1011　2025年5月
出版者・発行元： (一社)日本透析医学会
ISSN：1340-3451

eISSN：1883-082X
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy. 国際誌

Kei Takahashi, Emiko Sato, Seiko Yamakoshi, Mizuki Ogane, Akiyo Sekimoto, Takamasa Ishikawa, Kiyomi Kisu, Yuji Oe, Koji Okamoto, Mariko Miyazaki, Tetsuhiro Tanaka, Nobuyuki Takahashi

American journal of physiology. Renal physiology　2025年3月4日

DOI： 10.1152/ajprenal.00297.2024 　

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Podocytes are key components of the glomerular filtration barrier, and their injury leads to proteinuria, chronic kidney disease (CKD), and nephrotic syndrome. Effective treatments for these conditions are not well established, and prevention of podocyte injury is a crucial challenge. Nicotinamide (NAM), a form of vitamin B3, has been reported to exert beneficial effects in various renal disease models due to its antioxidant and anti-inflammatory properties and its ability to replenish nicotinamide adenine dinucleotide (NAD+). However, its impact on adriamycin (ADR)-induced nephropathy, a model of nephrotic syndrome caused by podocyte injury, remains unclear. We investigated the effects of NAM administration in a mouse model of ADR nephropathy. BALB/c mice were intravenously administered ADR to induce nephropathy. In the NAM-treated group, mice received 0.6% NAM in drinking water ad libitum starting 7 days before ADR administration. After 14 days, NAM treatment decreased albuminuria, glomerular sclerosis, and podocyte injury, and reduced inflammation and oxidative stress markers in the kidneys. NAM and NAD+ levels were decreased in ADR-treated kidneys, and the expression of the NAD+-consuming enzymes SIRT1 and PARP-1 was decreased and increased, respectively. Nicotinamide N-methyltransferase expression was increased. NAM canceled these abnormalities. In cultured rat podocytes, NAD+ alleviated ADR-induced cytotoxicity, apoptosis, and inflammation. These findings suggest that NAM prevents ADR nephropathy and podocyte injury, likely through NAD+ replenishment.
COVID-19の5類感染症変更後の地域医療において東北大学病院の救急科で診療を行った維持透析患者の検討

宮坂矩博, 秋保真穂, 岡本好司, 古川宗, 勝田賢, 柴田浩明, 小林淳, 宮崎真理子

宮城県腎不全研究会会誌　52回　24-25　2025年3月
出版者・発行元： (公財)宮城県腎臓協会
ISSN：2432-6402
Influence of infection control for COVID-19 on nutrition in relatively healthy Japanese HD patients: a retrospective observational study.

Yuki Chiba, Ryotaro Takahashi, Rui Makino, Mai Yoshida, Koji Okamoto, Tasuku Nagasawa, Ichiro Kato, Sadatoshi Ito, Tetsuhiro Tanaka, Mariko Miyazaki

Clinical and experimental nephrology　2025年2月28日

DOI： 10.1007/s10157-025-02638-3 　

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BACKGROUND: Infection control for the novel coronavirus disease 2019 (COVID-19) has been linked to decreased physical activity and nutritional deterioration in the general population; however, the influence on hemodialysis (HD) patients is not well discussed. METHODS: This multicenter retrospective study utilized the Geriatric Nutritional Risk Index (GNRI), Survival Index, and Nutritional Risk Index for Japanese HD patients (NRI-JH) to assess nutritional status and body composition over five observation periods. The primary endpoint was the body fluid removal rate (%) pre- and post-HD, whereas secondary endpoints included changes in GNRI, SI, body composition, and differences in NRI-JH. RESULTS: We enrolled 139 HD patients in three facilities. The results showed a decrease in GNRI score, which indicates nutritional deterioration, between February 2020 and August 2020 (96.8 (93.2-98.9) vs. 93.8 (90.8-97.6)) (P = 0.0005). Multivariable analysis revealed that nutritional deterioration was associated with higher C-reactive protein and lower hemoglobin levels (P = 0.0004 and P = 0.0010, respectively), which were more noticeable in the urban facility. Furthermore, nutritional deterioration was linked to a decrease in soft lean and somatic cell mass and an increase in body fat mass, suggesting reduced physical activity. CONCLUSIONS: Nutritional deterioration was observed shortly after the first COVID-19 outbreak, suggesting an association with decreased physical activity.
Waldenström's Macroglobulinemia/Lymphoplasmacytic Lymphoma Developing Renal AA Amyloidosis: A Case Report and Literature Review.

Yusuke Ishizuka, Yuji Oe, Sosuke Kinomura, Saori Kin, Yuji Noguchi, Koichi Kikuchi, Mai Yoshida, Rui Makino, Koji Okamoto, Tasuku Nagasawa, Takafumi Toyohara, Mariko Miyazaki, Hiroshi Sato, Yasushi Onishi, Hitoshi Warita, Tetsuhiro Tanaka

Internal medicine (Tokyo, Japan)　2025年2月8日

DOI： 10.2169/internalmedicine.4678-24 　

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AA amyloidosis is a rare renal complication of Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL). A 66-year-old man with WM/LPL presented with nephrotic syndrome. A renal biopsy showed AA amyloidosis. Chemotherapy resulted in the remission of hematologic and nephrotic syndromes. Two years into follow-up, he became infected with COVID-19 and had massive proteinuria, despite no relapse of WM/LPL. A second renal biopsy confirmed a diagnosis of AA amyloidosis. However, increased prednisolone did not improve proteinuria. The patient ultimately died of cryptococcal meningitis. This case highlights the diverse spectrum of renal involvement in monoclonal IgM-secreting diseases and difficulty in managing fatal complications.
Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases. 国際誌

Nonoka Suzuki, Kaname Kojima, Silvia Malvica, Kenshi Yamasaki, Yoichiro Chikamatsu, Yuji Oe, Tasuku Nagasawa, Ekyu Kondo, Satoru Sanada, Setsuya Aiba, Hiroshi Sato, Mariko Miyazaki, Sadayoshi Ito, Mitsuhiro Sato, Tetsuhiro Tanaka, Kengo Kinoshita, Yoshihide Asano, Avi Z Rosenberg, Koji Okamoto, Kosuke Shido

Communications medicine　5　(1)　3-3　2025年1月5日

DOI： 10.1038/s43856-024-00708-3 　

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BACKGROUND: Chronic kidney disease (CKD) causes progressive and irreversible damage to the kidneys. Renal biopsies are essential for diagnosing the etiology and prognosis of CKD, while accurate quantification of tubulo-interstitial injuries from whole slide images (WSIs) of renal biopsy specimens is challenging with visual inspection alone. METHODS: We develop a deep learning-based method named DLRS to quantify interstitial fibrosis and inflammatory cell infiltration as tubulo-interstitial injury scores, from WSIs of renal biopsy specimens. DLRS segments WSIs into non-tissue areas, glomeruli, tubules, interstitium, and arteries, and detects interstitial nuclei. It then quantifies these tubulo-interstitial injury scores using the segmented tissues and detected nuclei. RESULTS: Applied to WSIs from 71 Japanese CKD patients with diabetic nephropathy or benign nephrosclerosis, DLRS-derived scores show concordance with nephrologists' evaluations. Notably, the DLRS-derived fibrosis score has a higher correlation with the estimated glomerular filtration rate (eGFR) at biopsy than scores from nephrologists' evaluations. Validated on WSIs from 28 Japanese tubulointerstitial nephritis patients and 49 European-ancestry patients with nephrosclerosis, DLRS-derived scores show a significant correlation with eGFR. In an expanded analysis of 238 Japanese CKD patients, including 167 from another hospital, deviations in eGFR from expected values based on DLRS-derived scores correlate with annual eGFR decline after biopsy. Inclusion of these deviations and DLRS-derived fibrosis scores improve predictions of the annual eGFR decline. CONCLUSIONS: DLRS-derived tubulo-interstitial injury scores are concordant with nephrologists' evaluations and correlated with eGFR across different populations and institutions. The effectiveness of DLRS-derived scores for predicting annual eGFR decline highlights the potential of DLRS as a predictor of renal prognosis.
Erratum for Waldenström's Macroglobulinemia/Lymphoplasmacytic Lymphoma Developing Renal AA Amyloidosis: A Case Report and Literature Review.

Yusuke Ishizuka, Yuji Oe, Sosuke Kinomura, Saori Kin, Yuji Noguchi, Koichi Kikuchi, Mai Yoshida, Rui Makino, Koji Okamoto, Tasuku Nagasawa, Takafumi Toyohara, Mariko Miyazaki, Hiroshi Sato, Yasushi Onishi, Hitoshi Warita, Tetsuhiro Tanaka

Internal medicine (Tokyo, Japan)　64　(12)　1951-1951　2025年

DOI： 10.2169/internalmedicine.E001-25 　
The polymyxin-B direct hemoperfusion OPTimal Initiation timing with Catecholamine PMX-OPTIC study: A multicenter retrospective observational study. 国際誌

Kensuke Nakamura, Tetsuya Okazaki, Akihito Tampo, Katsunori Mochizuki, Naoki Kanda, Takahiro Ono, Kunio Yanagita, Taro Shimomura, Taichi Murase, Ken Saito, Takahiro Hirayama, Tomoaki Ito, Koji Ogawa, Mizuki Nakamura, Tomohiro Oda, Takeshi Morishima, Takuma Fukushima, Hiroharu Yasui, Naoki Akashi, Kojiro Oshima, Hiroo Kawarazaki, Tsukasa Akiba, Susumu Uemura, Yuhei Honma, Kenichi Nitta, Koji Okamoto, Shunsuke Takaki, Hirotaka Takeda, Chizuru Yamashita

Artificial organs　2024年9月18日

DOI： 10.1111/aor.14865 　

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BACKGROUND: Polymyxin-B direct hemoperfusion (PMX-DHP) is an endotoxin adsorption column-based blood purification therapy. Since one of the most potent effects of PMX-DHP is blood pressure elevations, it may be the most effective when it is introduced at the time when the need for vasopressors is the greatest, which, in turn, may reduce mortality. METHODS: A multicenter retrospective study was conducted at 24 ICUs in Japan. In each ICU, the 20 most recent consecutive cases of septic shock treated with PMX-DHP were analyzed. The duration between the time of the peak vasopressive agent dose, expressed as the noradrenaline equivalent dose (NEq), and the time of PMX initiation was evaluated. The primary outcome was 28-day mortality, and a multivariable analysis was performed to investigate factors associated with mortality. RESULTS: A total of 480 septic shock patients were included in the analysis. Among all patients, the 28-day mortality group was older, more severely ill, and had a higher body mass index. The NEq peak and NEq on PMX-DHP initiation were both higher in deceased patients. Regarding the timing of PMX-DHP initiation from the NEq peak, -4 << 4 h had more survivors (229/304, 75.3%) than ≤-4 h (50/75, 66.7%) and ≥4 h (66/101, 65.4%) (p = 0.085). When -4 << 4 h was assigned as a reference, the timing of PMX-DHP initiation from the NEq peak of ≤-4 h had an odds ratio of 1.96 (1.07-3.58), p = 0.029, while ≥4 h had an odds ratio of 1.64 (0.94-2.87), p = 0.082 for 28-day mortality, in the multivariable regression analysis. A spline curve of the relationship between the probability of death and the timing of PMX-DHP initiation from the NEq peak showed a downward convex curve with a nadir at timing = 0. The odds ratios of the timing of PMX-DHP initiation other than -4 << 4 h were significantly higher in an older age, male sex, lower BMI, more severe illness, and higher oxygenation. CONCLUSIONS: The induction of PMX-DHP at the time of the peak vasopressor dose correlated with lower mortality. PMX-DHP is one of the options available for elevating blood pressure in septic shock, and its initiation either too early or late for shock peak may not improve the outcome.
分娩後に劇症型A群レンサ球菌感染症による血栓性微小血管症(TMA)を合併した一例

金銅妃奈子, 岡本好司, 秋保真穂, 濱田裕貴, 只川まり, 岩間憲之, 齋藤昌利, 田中哲洋, 宮崎真理子

日本腎臓学会誌　66　(6-E)　883-883　2024年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
分娩時大量出血により発症した妊娠関連血栓性微小血管症(TMA)の一例

吉田舞, 石塚悠奨, 木之村聡介, 野口雄司, 金沙織, 菊地晃一, 大江佑治, 岡本好司, 豊原敬文, 宮崎真理子, 田中哲洋

日本腎臓学会誌　66　(6-E)　884-884　2024年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
溶血性尿毒症症候群に伴う意識障害が遷延した一例

野口雄司, 豊原敬文, 石塚悠奨, 木之村聡介, 金沙織, 菊地晃一, 吉田舞, 牧野塁, 岡本好司, 長澤将, 宮崎真理子, 田中哲洋

日本腎臓学会誌　66　(6-E)　913-913　2024年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
非典型的な臨床経過と腎病理を呈した多発血管炎性肉芽腫症

木之村聡介, 豊原敬文, 白井剛志, 秋保真穂, 菊地晃一, 牧野塁, 吉田舞, 大江佑治, 岡本好司, 長澤将, 宮崎真理子, 佐藤博, 藤井博司, 田中哲洋

日本腎臓学会誌　66　(6-E)　957-957　2024年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy. 国際誌

Teruhiko Yoshida, Khun Zaw Latt, Avi Z Rosenberg, Briana A Santo, Komuraiah Myakala, Yu Ishimoto, Yongmei Zhao, Shashi Shrivastav, Bryce A Jones, Xiaoping Yang, Xiaoxin X Wang, Vincent M Tutino, Pinaki Sarder, Moshe Levi, Koji Okamoto, Cheryl A Winkler, Jeffrey B Kopp

eLife　12　2024年8月29日

DOI： 10.7554/eLife.91260 　

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HIV disease remains prevalent in the USA and chronic kidney disease remains a major cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a sensor for viral dsRNA, including HIV-1. We show that PKR inhibition by compound C16 ameliorates the HIV-associated nephropathy (HIVAN) kidney phenotype in the Tg26 transgenic mouse model, with reversal of mitochondrial dysfunction. Combined analysis of single-nucleus RNA-seq and bulk RNA-seq data revealed that oxidative phosphorylation was one of the most downregulated pathways and identified signal transducer and activator of transcription (STAT3) as a potential mediating factor. We identified in Tg26 mice a novel proximal tubular cell cluster enriched in mitochondrial transcripts. Podocytes showed high levels of HIV-1 gene expression and dysregulation of cytoskeleton-related genes, and these cells dedifferentiated. In injured proximal tubules, cell-cell interaction analysis indicated activation of the pro-fibrogenic PKR-STAT3-platelet-derived growth factor (PDGF)-D pathway. These findings suggest that PKR inhibition and mitochondrial rescue are potential novel therapeutic approaches for HIVAN.
Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice. 国際誌

Khun Zaw Latt, Teruhiko Yoshida, Shashi Shrivastav, Amin Abedini, Jeff M Reece, Zeguo Sun, Hewang Lee, Koji Okamoto, Pradeep Dagur, Yu Ishimoto, Jurgen Heymann, Yongmei Zhao, Joon-Yong Chung, Stephen Hewitt, Pedro A Jose, Kyung Lee, John Cijiang He, Cheryl A Winkler, Mark A Knepper, Tomoshige Kino, Avi Z Rosenberg, Katalin Susztak, Jeffrey B Kopp

The American journal of pathology　194　(10)　1844-1856　2024年7月18日

DOI： 10.1016/j.ajpath.2024.06.006 　

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Although hyponatremia and salt wasting are common in patients with HIV/AIDS, the understanding of their contributing factors is limited. HIV viral protein R (Vpr) contributes to HIV-associated nephropathy. To investigate the effects of Vpr on the distal tubules and on the expression level of the Slc12a3 gene, encoding the sodium-chloride cotransporter (which is responsible for sodium reabsorption in distal nephron segments), single-nucleus RNA sequencing was performed on kidney cortices from three wild-type (WT) and three Vpr transgenic (Vpr Tg) mice. The results show that the percentage of distal convoluted tubule (DCT) cells was significantly lower in Vpr Tg mice compared with WT mice (P < 0.05); in Vpr Tg mice, Slc12a3 expression was not significantly different in DCT cells. The Pvalb+ DCT1 subcluster had fewer cells in Vpr Tg mice compared with WT mice (P < 0.01). Immunohistochemistry revealed fewer Slc12a3+Pvalb+ DCT1 segments in Vpr Tg mice. Differential gene expression analysis between Vpr Tg and WT samples in the DCT cluster showed down-regulation of the Ier3 gene, which is an inhibitor of apoptosis. The in vitro knockdown of Ier3 by siRNA transfection induced apoptosis in mouse DCT cells. These observations suggest that the salt-wasting effect of Vpr in Vpr Tg mice is likely mediated by Ier3 down-regulation in DCT1 cells and loss of Slc12a3+Pvalb+ DCT1 segments.
HIV viral protein R induces loss of DCT1-type renal tubules. 国際誌

Khun Zaw Latt, Teruhiko Yoshida, Shashi Shrivastav, Amin Abedini, Jeff M Reece, Zeguo Sun, Hewang Lee, Koji Okamoto, Pradeep Dagur, Jurgen Heymann, Yongmei Zhao, Joon-Yong Chung, Stephen Hewitt, Pedro A Jose, Kyung Lee, John Cijiang He, Cheryl A Winkler, Mark A Knepper, Tomoshige Kino, Avi Z Rosenberg, Katalin Susztak, Jeffrey B Kopp

bioRxiv : the preprint server for biology　2023年11月13日

DOI： 10.1101/2023.02.02.526686 　

詳細を見る詳細を閉じる

Hyponatremia and salt wasting is a common occurance in patients with HIV/AIDS, however, the understanding of its contributing factors is limited. HIV viral protein R (Vpr) contributes to HIV-associated nephropathy. To investigate the effects of Vpr on the expression level of the Slc12a3 gene, encoding the Na-Cl cotransporter, which is responsible for sodium reabsorption in distal nephron segments, we performed single-nucleus RNA sequencing of kidney cortices from three wild-type (WT) and three Vpr-transgenic (Vpr Tg) mice. The results showed that the percentage of distal convoluted tubule (DCT) cells was significantly lower in Vpr Tg mice compared with WT mice (P < 0.05), and that in Vpr Tg mice, Slc12a3 expression was not different in DCT cell cluster. The Pvalb+ DCT1 subcluster had fewer cells in Vpr Tg mice compared with WT (P < 0.01). Immunohistochemistry demonstrated fewer Slc12a3+ Pvalb+ DCT1 segments in Vpr Tg mice. Differential gene expression analysis comparing Vpr Tg and WT in the DCT cluster showed Ier3, an inhibitor of apoptosis, to be the most downregulated gene. These observations demonstrate that the salt-wasting effect of Vpr in Vpr Tg mice is mediated by loss of Slc12a3+ Pvalb+ DCT1 segments via apoptosis dysregulation.
東北大学病院における透析非導入症例の緩和ケアの現状

藤倉恵美, 岡本好司, 吉田舞, 宮崎真理子, 田中哲洋

日本腎臓学会誌　65　(6-E)　578-578　2023年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
形質細胞腫に続発したネフローゼ症候群の一例

金沙織, 岡本好司, 吉田舞, 長澤将, 宮崎真理子, 田中哲洋

日本腎臓学会誌　65　(6-E)　587-587　2023年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
修正型大血管転移症を伴う三尖弁閉鎖症の末期腎不全患者に対して腹膜透析を導入した一例

今田悠介, 岡本好司, 吉田舞, 牧野塁, 長澤将, 宮崎真理子, 田中哲洋

日本腎臓学会誌　65　(6-E)　606-606　2023年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
血液透析導入に至ったアラジール症候群(ALGS)の一例

吉田舞, 岡本好司, 長澤将, 戸子台和哲, 宮崎真理子, 田中哲洋

日本透析医学会雑誌　56　(Suppl.1)　779-779　2023年5月
出版者・発行元： (一社)日本透析医学会
ISSN：1340-3451

eISSN：1883-082X
Marked reduction of proteinuria after removal of a growth hormone-producing pituitary adenoma in a patient with focal segmental glomerulosclerosis: a case report and literature review.

Shizuka Ishigaki, Yuji Oe, Kei Omata, Yoshikiyo Ono, Yuta Tezuka, Ryo Morimoto, Shun Watanabe, Hiroyasu Nishioka, Fumitoshi Satoh, Mai Yoshida, Rui Makino, Koji Okamoto, Tasuku Nagasawa, Naoko Inoshita, Shozo Yamada, Hiroshi Sato, Sadayoshi Ito, Mariko Miyazaki

CEN case reports　12　(2)　164-170　2022年10月6日

DOI： 10.1007/s13730-022-00739-6 　

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Focal segmental glomerulosclerosis is a rare complication of acromegaly. A 74-year-old man was found to have acromegaly features such as enlargement of the forehead, nose, and hands. Laboratory tests showed a urine protein/creatinine ratio of 3.16 g/gCr and serum creatinine of 1.34 mg/dL. The levels of growth hormone and insulin-like growth factor I were markedly elevated, and the growth hormone level was not suppressed after 75 g oral glucose loading. Magnetic resonance imaging revealed a pituitary tumor with a diameter of 1.2 cm. Renal biopsy confirmed the diagnosis of focal segmental glomerulosclerosis. Transsphenoidal resection of the pituitary tumor led to remission of acromegaly and reduction in proteinuria highlighting the causal link between growth hormone overproduction and proteinuria. Treatment of acromegaly may be effective for acromegaly-associated focal segmental glomerulosclerosis.
腎サルコイドーシス患者における新規バイオマーカーの探索

千葉祐貴, 牧野塁, 吉田舞, 長澤将, 宮崎真理子, 田中哲洋, 村上康司, 玉田勉, 岡本好司

日本サルコイドーシス/肉芽腫性疾患学会雑誌　42　(サプリメント号)　63-63　2022年10月
出版者・発行元：日本サルコイドーシス
ISSN：1883-1273

eISSN：1884-6114
肺移植後に発症したカルシニューリン阻害薬腎症による末期腎不全に対し腎移植を施行した一例

今田悠介, 長澤将, 吉田舞, 牧野塁, 岡本好司, 宮崎真理子, 田中哲洋

日本腎臓学会誌　64　(6-E)　551-551　2022年10月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
先天性複雑心奇形を伴う慢性腎不全患者に腹膜透析を導入した一例

玉懸直人, 岡本好司, 吉田舞, 牧野塁, 長澤将, 宮崎真理子, 田中哲洋

日本腎臓学会誌　64　(6-E)　555-555　2022年10月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
血液透析を離脱できたCOVID-19治療中に発症した急性尿細管壊死の一例

古田銀次, 牧野塁, 吉田舞, 岡本好司, 長澤将, 宮崎真理子, 田中哲洋

日本腎臓学会誌　64　(6-E)　566-566　2022年10月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
Antisense oligonucleotides ameliorate kidney dysfunction in podocyte-specific APOL1 risk variant mice. 国際誌

Ya-Wen Yang, Bibek Poudel, Julia Frederick, Poonam Dhillon, Rojesh Shrestha, Ziyuan Ma, Junnan Wu, Koji Okamoto, Jeffrey B Kopp, Sheri L Booten, Danielle Gattis, Andrew T Watt, Matthew Palmer, Mariam Aghajan, Katalin Susztak

Molecular therapy : the journal of the American Society of Gene Therapy　30　(7)　2491-2504　2022年7月6日

DOI： 10.1016/j.ymthe.2022.04.007 　

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Coding variants (named G1 and G2) in Apolipoprotein L1 (APOL1) can explain most excess risk of kidney disease observed in African American individuals. It has been proposed that risk variant APOL1 dose, such as increased risk variant APOL1 level serves as a trigger (second hit) for disease development. The goal of this study was to determine whether lowering risk variant APOL1 levels protects from disease development in a podocyte-specific transgenic mouse disease model. We administered antisense oligonucleotides (ASO) targeting APOL1 to podocyte-specific G2APOL1 mice and observed efficient reduction of APOL1 levels. APOL1 ASO1, which more efficiently lowered APOL1 transcript levels, protected mice from albuminuria, glomerulosclerosis, tubulointerstitial fibrosis, and renal failure. Administration of APOL1 ASO1 was effective even for established disease in the NEFTA-rtTA/TRE-G2APOL1 (NEFTA/G2APOL1) mice. We observed a strong correlation between APOL1 transcript level and disease severity. We concluded that APOL1 ASO1 may be an effective therapeutic approach for APOL1-associated glomerular disease.
The physiological and pathophysiological roles of carbohydrate response element binding protein in the kidney.

Atsushi Yokoyama, Susumu Suzuki, Koji Okamoto, Akira Sugawara

Endocrine journal　69　(6)　605-612　2022年6月28日

DOI： 10.1507/endocrj.EJ22-0083 　

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Glucose is not only the energy fuel for most cells, but also the signaling molecule which affects gene expression via carbohydrate response element binding protein (ChREBP), a Mondo family transcription factor. In response to high glucose conditions, ChREBP regulates glycolytic and lipogenic genes by binding to carbohydrate response elements (ChoRE) in the regulatory region of its target genes, thus elucidating the role of ChREBP for converting excessively ingested carbohydrates to fatty acids as an energy storage in lipogenic tissues such as the liver and adipose tissue. While the pathophysiological roles of ChREBP for fatty liver and obesity in these tissues are well known, much of the physiological and pathophysiological roles of ChREBP in other tissues such as the kidney remains unclear despite its high levels of expression in them. This review will thus highlight the roles of ChREBP in the kidney and briefly introduce the latest research results that have been reported so far.
腎サルコイドーシス患者における新規バイオマーカーの探索

千葉祐貴, 吉田舞, 牧野塁, 長澤将, 宮崎真理子, 岡本好司

日本腎臓学会誌　64　(3)　291-291　2022年5月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
感染症を繰り返し半月体形成性糸球体腎炎から透析導入に至ったKlippel-Trenauna y-Weber症候群(KTWS)の一例

吉田舞, 千葉祐貴, 高橋慧, 大江佑治, 牧野塁, 岡本好司, 藤倉恵美, 長澤将, 栗原功, 宮崎真理子

日本透析医学会雑誌　55　(Suppl.1)　683-683　2022年5月
出版者・発行元： (一社)日本透析医学会
ISSN：1340-3451

eISSN：1883-082X
HIV-1 Vpr suppresses expression of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule. 国際誌

Shashi Shrivastav, Hewang Lee, Koji Okamoto, Huiyan Lu, Teruhiko Yoshida, Khun Zaw Latt, Hidefumi Wakashin, James L T Dalgleish, Erik H Koritzinsky, Peng Xu, Laureano D Asico, Joon-Yong Chung, Stephen Hewitt, John J Gildea, Robin A Felder, Pedro A Jose, Avi Z Rosenberg, Mark A Knepper, Tomoshige Kino, Jeffrey B Kopp

PloS one　17　(9)　e0273313　2022年

DOI： 10.1371/journal.pone.0273313 　

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HIV-associated nephropathy (HIVAN) impairs functions of both glomeruli and tubules. Attention has been previously focused on the HIVAN glomerulopathy. Tubular injury has drawn increased attention because sodium wasting is common in hospitalized HIV/AIDS patients. We used viral protein R (Vpr)-transgenic mice to investigate the mechanisms whereby Vpr contributes to urinary sodium wasting. In phosphoenolpyruvate carboxykinase promoter-driven Vpr-transgenic mice, in situ hybridization showed that Vpr mRNA was expressed in all nephron segments, including the distal convoluted tubule. Vpr-transgenic mice, compared with wild-type littermates, markedly increased urinary sodium excretion, despite similar plasma renin activity and aldosterone levels. Kidneys from Vpr-transgenic mice also markedly reduced protein abundance of the Na+-Cl- cotransporter (NCC), while mineralocorticoid receptor (MR) protein expression level was unchanged. In African green monkey kidney cells, Vpr abrogated the aldosterone-mediated stimulation of MR transcriptional activity. Gene expression of Slc12a3 (NCC) in Vpr-transgenic mice was significantly lower compared with wild-type mice, assessed by both qRT-PCR and RNAScope in situ hybridization analysis. Chromatin immunoprecipitation assays identified multiple MR response elements (MRE), located from 5 kb upstream of the transcription start site and extending to the third exon of the SLC12A3 gene. Mutation of MRE and SP1 sites in the SLC12A3 promoter region abrogated the transcriptional responses to aldosterone and Vpr, indicating that functional MRE and SP1 are required for the SLC12A3 gene suppression in response to Vpr. Thus, Vpr attenuates MR transcriptional activity and inhibits Slc12a3 transcription in the distal convoluted tubule and contributes to salt wasting in Vpr-transgenic mice.
Glomerulonephritis Associated with Infective Endocarditis Showing Serological Positivity for PR3-anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody.

Yuki Chiba, Kei Takahashi, Rui Makino, Mai Yoshida, Yuji Oe, Tasuku Nagasawa, Hiroshi Sato, Mariko Miyazaki, Koji Okamoto

Internal medicine (Tokyo, Japan)　61　(14)　2179-2185　2021年12月28日

DOI： 10.2169/internalmedicine.8385-21 　

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We herein report a case of crescentic glomerulonephritis associated with infective endocarditis (IE). A 61-year-old-woman presented with a fever and renal dysfunction and was diagnosed with IE. The patient was positive for PR3-ANCA and anti-GBM antibodies. Renal biopsy findings showed crescentic glomerulonephritis with isolated deposition of C3c, a serum conversion product of complement C3. Given these clinical findings, the patient was diagnosed with IE-associated glomerulonephritis. Antibiotic therapy was continued without immunosuppressive agents. After the initiation of the antibiotics, the fever resolved, and the renal function gradually recovered. This case highlights the notion that laboratory findings should be carefully evaluated with reference to other findings.
Myeloid cell-derived coagulation tissue factor is associated with renal tubular damage in mice fed an adenine diet

Shu Yamakage, Yuji Oe, Emiko Sato, Koji Okamoto, Akiyo Sekimoto, Satoshi Kumakura, Hiroshi Sato, Mai Yoshida, Tasuku Nagasawa, Mariko Miyazaki, Sadayoshi Ito, Nigel Mackman, Nobuyuki Takahashi

Scientific Reports　11　(1)　2021年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41598-021-91586-5 　

eISSN：2045-2322

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<title>Abstract</title>Patients with chronic kidney disease (CKD) commonly exhibit hypercoagulability. Increased levels of uremic toxins cause thrombogenicity by increasing tissue factor (TF) expression and activating the extrinsic coagulation cascade. TF is induced in monocytes and macrophages under pathological conditions, such as inflammatory diseases. However, the role of monocyte myeloid cell TF in CKD progression remains unclear. We aimed to clarify this issue, and the present study found that patients with CKD had elevated levels of D-dimer, a marker of fibrin degradation, which was associated with decreased estimated glomerular filtration rate and increased serum levels of uremic toxins, such as indoxyl sulfate. In vitro studies showed that several uremic toxins increased cellular TF levels in monocytic THP-1 cells. Mice with TF specifically deleted in myeloid cells were fed an adenine diet to cause uremic kidney injury. Myeloid TF deletion reduced tubular injury and pro-inflammatory gene expression in the kidneys of adenine-induced CKD but did not improve renal function as measured by plasma creatinine or blood urea nitrogen. Collectively, our findings suggest a novel concept of pathogenesis of coagulation-mediated kidney injury, in which elevated TF levels in monocytes under uremic conditions is partly involved in the development of CKD.
組織学的評価を踏まえ腎移植マージナルドナーの適格性を判断した1例

石岡広崇, 牧野塁, 吉田舞, 大江佑治, 岡本好司, 長澤将, 宮崎真理子, 戸子台和哲, 宮城重人, 佐藤博

日本腎臓学会誌　63　(6-E)　724-724　2021年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
Correction to: Genome-wide association study identifies new loci for albuminuria in the Japanese population.

Hiroshi Okuda, Koji Okamoto, Michiaki Abe, Kota Ishizawa, Satoshi Makino, Osamu Tanabe, Junichi Sugawara, Atsushi Hozawa, Kozo Tanno, Makoto Sasaki, Gen Tamiya, Masayuki Yamamoto, Sadayoshi Ito, Tadashi Ishii

Clinical and experimental nephrology　25　(5)　565-565　2021年5月

DOI： 10.1007/s10157-021-02053-4 　
Retrospective study revealed that Zn relate to improvement of swallowing function in the older adults. 国際誌

Yumika Seki, Kota Ishizawa, Tetsuya Akaishi, Michiaki Abe, Koji Okamoto, Junichi Tanaka, Ryutaro Arita, Shin Takayama, Akiko Kikuchi, Mariko Miyazaki, Hideo Harigae, Mayumi Sato, Masaya Hoshi, Kazuaki Hatsugai, Tadashi Ishii

BMC geriatrics　21　(1)　279-279　2021年4月26日

DOI： 10.1186/s12877-021-02224-8 　

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BACKGROUND: Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In older adults patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before. METHODS: A total of 52 older adults subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured. RESULTS: At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson's R = 0.58, p < 0.0001) and time in the S-SPT (Spearman's rho = - 0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the older adults who had comorbid dysphagia and zinc deficiency. CONCLUSIONS: Zinc deficiency is associated with compromised swallowing function in older adults patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in older adults patients with zinc deficiency even though this is a retrospective study. Further study will be needed to confirm this positive effect.
A Novel Mutation in LMX1B (p.Pro219Ala) Causes Focal Segmental Glomerulosclerosis with Alport Syndrome-like Phenotype.

Yuji Oe, Eikan Mishima, Takayasu Mori, Koji Okamoto, Yohei Honkura, Tasuku Nagasawa, Mai Yoshida, Hiroshi Sato, Jun Suzuki, Ryoukichi Ikeda, Eisei Sohara, Shinichi Uchida, Yukio Katori, Mariko Miyazaki

Internal medicine (Tokyo, Japan)　60　(18)　2991-2996　2021年4月5日

DOI： 10.2169/internalmedicine.6987-20 　

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A 69-year-old woman presented with mild renal dysfunction, proteinuria, and sensorineural hearing loss. A renal biopsy showed focal segmental glomerulosclerosis with thinning of the glomerular basement membrane. There was a positive family history of end-stage kidney disease and hearing loss. Although Alport syndrome was suspected from these features, a genetic test using next-generation sequencer identified a novel missense mutation in LMX1B, c.655C>G: p. (Pro219Ala). In silico analyses predicted the pathogenicity of the mutation. Thus, the present case was diagnosed as LMX1B-associated nephropathy presenting with Alport syndrome-like phenotype, expanding the disease spectrum of LMX1B nephropathy.
Spontaneous remission of minimal change nephrotic syndrome in an elderly man.

Yuki Chiba, Tasuku Nagasawa, Saori Kin, Kei Takahashi, Mai Yoshida, Yuji Oe, Koji Okamoto, Hiroshi Sato, Mariko Miyazaki

CEN case reports　10　(2)　301-307　2021年1月4日

DOI： 10.1007/s13730-020-00554-x 　

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Minimal change nephrotic syndrome (MCNS) cases achieving spontaneous remission without external factors are rarely reported. We report a case of MCNS that achieved spontaneous remission without external factors that triggered its onset. An 82-year-old male patient was admitted to the hospital for close examination of nephrotic syndrome. Renal biopsy was performed and MCNS was diagnosed. Owing to the patient's age and history of foot and microvascular arteriovenous thrombosis, we did not start immunosuppressive drugs, including steroids, and opted for conservative management. After conservative treatment, proteinuria gradually decreased, and the patient achieved complete remission. Given that the patient had a history of urinary protein and thrombosis, recurrence of MCNS was considered again this time. In addition, the involvement of external factors that trigger the onset of MCNS was not found. In conclusion, in elderly-onset MCNS, clinicians generally hesitate to initiate treatment with an immunosuppressive drug, containing steroids, because of its many complications. Thus, our data provide valuable insight into MCNS.
症例による透析患者の画像診断維持血液透析患者に発症した進行性多巣性白質脳症の1例査読有り

千葉祐貴, 割田仁, 中道一生, 宮崎真理子, 小山千佳, 小島慶恵, 吉田舞, 大江佑治, 岡本好司, 藤倉恵美, 長澤将, 西山修平

臨床透析　36　(11)　1473-1476　2020年10月
出版者・発行元： (株)日本メディカルセンター
ISSN：0910-5808

eISSN：2433-247X

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症例は67歳女性で、12年前よりループス腎炎による慢性腎不全に対して維持血液透析を開始された。今回、構音障害、意識障害が出現し、前医にて左前頭葉脳梗塞の診断で入院加療となった。リハビリテーションを継続していたが四肢麻痺および失語症の症状は悪化し、頭部MRI検査にて皮質下白質を中心に異常信号域を指摘され、精査および加療目的に当院救急科に入院となった。進行性多巣性白質脳症(PML)の診断目的に髄液検査を施行し、JCウイルス(JCV)-DNAはcopy数1673/mLと陽性であり、病理学的検査によるPMLの診断基準より、probable PMLの診断となった。抗精神病薬アセナピンで治療を開始し、開始1ヵ月後には神経学的所見は横ばいであったが、MRI検査では脳病変が縮小していた。髄液検査ではJCV-DNAはcopy数76/mLと改善を認めたが、その後、結腸穿通による腹腔内膿瘍を合併し、第120病日に永眠された。
外的要因無く発症し自然寛解に至った高齢微小変化型ネフローゼ症候群の一例

千葉祐貴, 吉田舞, 大江佑治, 岡本好司, 長澤将, 宮崎真理子

日本腎臓学会誌　62　(6)　539-539　2020年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
血液透析非導入となった終末期高齢患者の一例改訂後の「提言」と透析治療の「無益性」

藤倉恵美, 金沙織, 吉田舞, 大江祐治, 岡本好司, 宮崎真理子

日本腎臓学会誌　62　(6)　557-557　2020年9月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
Questionnaire survey on the prescription of renal replacement therapy for acute phase patients on maintenance dialysis who developed cerebrovascular disease.

Maho Akiu, Tae Yamamoto, Emi Fujikura, Koji Okamoto, Atsuhiro Nakagawa, Mai Yoshida, Takashi Nakamichi, Taro Fukushi, Tasuku Nagasawa, Yuji Oe, Masaaki Nakayama, Hiroshi Sato, Teiji Tominaga, Sadayoshi Ito, Hideo Harigae, Mariko Miyazaki

Clinical and experimental nephrology　24　(9)　821-828　2020年9月

DOI： 10.1007/s10157-020-01905-9 　

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BACKGROUND: There is limited information about acute phase renal replacement therapy (RRT) for maintenance hemodialysis patients after the onset of cerebrovascular disease. This study aimed to investigate which modality of renal replacement therapy is currently selected in practice. METHODS: We conducted a mail-based survey in 317 dialysis facilities that were certified by three academic societies that focus on dialysis, neurology, and neurosurgery in Japan. RESULTS: We received responses from 103 facilities (32.5%). In cases of cerebral infarction (CI) and intracerebral hemorrhage (ICH), more than 80% of the facilities selected only intermittent RRT, and 22.3% (CI)/8.7% (ICH) of the facilities selected intermittent HD which is the same setting in normal conditions. Although continuous hemodiafiltration and peritoneal dialysis are recommended in the Japanese guidelines, these were selected in only a few facilities: 16.5% and 0% in CI, 16.5% and 1% in ICH, respectively. RRT on the day of onset tended to be avoided, irrespective of the duration following the last HD session. Furthermore, physicians preferred to modify anticoagulants and reduce dialysis performance in the acute phase. CONCLUSION: This questionnaire survey uncovered a gap between guidelines and actual practice, even in hospitals accredited as educational facility, which is a novel and important finding. Further studies with larger sample sizes are needed to determine the optimal modality of RRT for the acute phase of cerebrovascular disease.
Genome-wide association study identifies new loci for albuminuria in the Japanese population.

Hiroshi Okuda, Koji Okamoto, Michiaki Abe, Kota Ishizawa, Satoshi Makino, Osamu Tanabe, Junichi Sugawara, Atsushi Hozawa, Kozo Tanno, Makoto Sasaki, Gen Tamiya, Masayuki Yamamoto, Sadayoshi Ito, Tadashi Ishii

Clinical and experimental nephrology　24　(8)　1-9　2020年8月

DOI： 10.1007/s10157-020-01884-x 　

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BACKGROUND: Urinary albumin excretion (UAE) is a risk factor for cardiovascular diseases, metabolic syndrome, chronic kidney disease, etc. Only a few genome-wide association studies (GWAS) for UAE have been conducted in the European population, but not in the Asian population. Here we conducted GWAS and identified several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population. METHODS: We conducted GWAS for UAE in 7805 individuals of Asian ancestry from health-survey data collected by Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM). The SNP genotype data were obtained with a SNP microarray. After imputation using a haplotype panel consisting of 2000 genome sequencing, 4,962,728 SNP markers were used for the GWAS. RESULTS: Eighteen SNPs at 14 loci (GRM7, EXOC1/NMU, LPA, STEAP1B/RAPGEF5, SEMA3D, PRKAG2, TRIQK, SERTM1, TPT1-AS1, OR5AU1, TSHR, FMN1/RYR3, COPRS, and BRD1) were associated with UAE in the Japanese individuals. A locus with particularly strong associations was observed on TSHR, chromosome 14 [rs116622332 (p = 3.99 × 10-10)]. CONCLUSION: In this study, we successfully identified UAE-associated variant loci in the Japanese population. Further study is required to confirm this association.
単球・マクロファージ由来組織因子の慢性腎臓病における役割

山陰周, 大江佑治, 佐藤恵美子, 堰本晃代, 岡本好司, 宮崎真理子, 佐藤博, 伊藤貞嘉, 高橋信行

日本腎臓学会誌　62　(4)　284-284　2020年7月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
内皮型NO合成酵素欠損はCKD関連異所性石灰化を誘導する

大江佑治, 佐藤恵美子, 宮崎真理子, 岡本好司, 佐藤博, 伊藤貞嘉, 高橋信行

日本腎臓学会誌　62　(4)　285-285　2020年7月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
住民コホートを使った尿中アルブミン排泄量に関する量的形質遺伝子座の検討

岡本好司, 奥田拓史, 石井正, 佐々木真理, 田宮元, 山本雅之, 阿部倫明

日本腎臓学会誌　62　(4)　261-261　2020年7月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
住民コホートを使った尿中アルブミン排泄量に関する量的形質遺伝子座の検討

岡本好司, 奥田拓史, 石井正, 佐々木真理, 田宮元, 山本雅之, 阿部倫明

日本腎臓学会誌　62　(4)　261-261　2020年7月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
Kidney function, blood pressure and proteinuria were associated with pregnancy outcomes of pregnant women with chronic kidney disease: a single-center, retrospective study in the Asian population.

Satoshi Kumakura, Koji Okamoto, Saeko Takeuchi, Mai Yoshida, Takashi Nakamichi, Tasuku Nagasawa, Emi Fujikura, Tae Yamamoto, Masatoshi Saito, Takushi Hanita, Michihiro Satoh, Hiroshi Sato, Sadayoshi Ito, Hideo Harigae, Mariko Miyazaki

Clinical and experimental nephrology　24　(6)　547-556　2020年6月

DOI： 10.1007/s10157-020-01865-0 　

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BACKGROUND: Studies among pregnant Asian women with chronic kidney disease (CKD) have not been widely performed; therefore, clinical criteria for these patients have not been well established. METHODS: We conducted a retrospective study among pregnant women with CKD who received prenatal care at our institution for 8 consecutive years. Primary outcome was the development of severe adverse events (SAEs). We analyzed correlations between primary outcome and CKD parameters [age, body mass index (BMI), estimated glomerular filtration rate (eGFR), urinary protein-creatinine ratio (UP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and not normal blood pressure (non-NBP)] at the time of referral. Secondary outcomes were low birth weight (LBW), preterm delivery (PreD), and small for gestational age (SGA). We divided into two categories, CKD stage G1, and G2 or higher according to eGFR, and proteinuria negative and proteinuria positive according to UP, respectively. RESULTS: We observed 89 pregnancies. SAE was observed in 28 pregnancies. In live birth cases, there were 28 PreD, 28 LBW and 13 SGA. Major SAEs included preeclampsia, superimposed preeclampsia, unscheduled cesarean section, neonatal intensive care unit admission, and fetal death. Stepwise logistic regression analysis selected eGFR (OR = 0.847, p = 0.026), SBP (OR = 1.897, p = 0.006) and proteinuria positive (OR = 2.96, p = 0.046) as the significant predictors of SAEs. There were no significant differences among the baseline characteristics stratified by SGA. CONCLUSIONS: This is the first study to report pregnancy outcomes among Japanese non-disease-oriented patients with CKD. In Asians, especially in the Japanese population, kidney function, blood pressure and proteinuria might affect pregnancy outcomes.
IgA腎症患者は妊娠前に治療し血圧正常化を目指すべき IgA腎症合併妊娠の産科合併症リスクの検討

熊倉慧, 竹内沙永子, 吉田舞, 岡本好司, 中道崇, 長澤将, 山本多恵, 藤倉恵美, 宮崎真理子

日本腎臓学会誌　61　(3)　305-305　2019年5月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice. 国際誌

Jung-Hwa Ryu, Mengyuan Ge, Sandra Merscher, Avi Z Rosenberg, Marco Desante, Hila Roshanravan, Koji Okamoto, Myung K Shin, Maarten Hoek, Alessia Fornoni, Jeffrey B Kopp

PloS one　14　(4)　e0211559　2019年

DOI： 10.1371/journal.pone.0211559 　

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Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in African descent populations. APOL1 is a minor protein component of HDL, as well as being expressed in podocytes and vascular cells. Reverse cholesterol transport involves the transport of cholesterol to HDL by cellular ATP-binding cassette; ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. With impaired reverse cholesterol transport, lipid accumulation occurs and macrophages morphologically transform into foam cells, releasing inflammatory factors. We asked whether the APOL1 risk variants alter peripheral cholesterol metabolism and specifically affect macrophage cholesterol efflux. Tissues and bone marrow (BM)-derived monocytes were isolated from wild-type mice (WT) and from BAC/APOL1 transgenic (APOL1-G0, APOL1-G1, and APOL1-G2) mice, which carry a bacterial artificial chromosome that contains the human APOL1 genomic region. Monocytes were differentiated into macrophages using M-CSF, and then polarized into M1 and M2 macrophages. Cholesterol content, cholesterol efflux, and ABCA1 and ABCG1 mRNA expression were measured. Kidney, spleen, and bone marrow-derived macrophages from APOL1-G1 and -G2 mice showed increased cholesterol accumulation and decreased ABCA1 and ABCG1 mRNA levels. BM-derived macrophages from APOL1-G1 and -G2 mice showed significantly reduced cholesterol efflux compared to WT or APOL1-G0 macrophages. Taken together, the evidence suggests that APOL1-G1 and -G2 risk variants impaired reverse cholesterol transport through decreased expression of cholesterol efflux transporters suggesting a possible mechanism to promote macrophage foam cell formation, driving inflammation in the glomerulus and renal interstitium.
ApoL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase-2. 国際誌査読有り

Hewang Lee, Hila Roshanravan, Ying Wang, Koji Okamoto, Junghwa Ryu, Shashi Shrivastav, Peng Qu, Jeffrey B Kopp

American journal of physiology. Renal physiology　315　(1)　F140-F150-F150　2018年7月1日

DOI： 10.1152/ajprenal.00254.2017 　

ISSN：1931-857X

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Apolipoprotein L1 ( ApoL1) genetic variants are strongly associated with kidney diseases. We investigated the role of ApoL1 variants in monocyte differentiation and eicosanoid production in macrophages, as activated tissue macrophages in kidney might contribute to kidney injury. In human monocyte THP-1 cells, transient overexpression of ApoL1 (G0, G1, G2) by transfection resulted in a 5- to 11-fold increase in CD14 and CD68 gene expression, similar to that seen with phorbol-12-myristate acetate treatment. All ApoL1 variants caused monocytes to differentiate into atypical M1 macrophages with marked increase in M1 markers CD80, TNF, IL1B, and IL6 and modest increase in the M2 marker CD163 compared with control cells. ApoL1-G1 transfection induced additional CD206 and TGFB1 expression, and ApoL1-G2 transfection induced additional CD204 and TGFB1 expression. Gene expression of prostaglandin E2 (PGE2) synthase and thromboxane synthase and both gene and protein expression of cyclooxygenase-2 (COX-2) were increased by ApoL1-G1 and -G2 variants compared with -G0 transfection. Higher levels of PGE2 and thromboxane B2, a stable metabolite of thromboxane A2, and transforming growth factor (TGF)-β1 were released into the supernatant of cultured THP-1 cells transfected with ApoL1-G1 and -G2, but not -G0. The increase in PGE2, thromboxane B2, and TGF-β1 was inhibited by COX-2-specific inhibitor CAY10404 but not by COX-1-specific inhibitor SC-560. These results demonstrate a novel role of ApoL1 variants in the regulation of monocyte differentiation and eicosanoid metabolism, which could modify the immune response and promote inflammatory signaling within the local targeted organs and tissues including the kidney.
Hierarchical Assembly of siRNA with Tetraamino Fullerene in Physiological Conditions for Efficient Internalization into Cells and Knockdown. 国際誌査読有り

Kosuke Minami, Koji Okamoto, Koji Harano, Eisei Noiri, Eiichi Nakamura

ACS applied materials & interfaces　10　(23)　19347-19354　2018年6月13日
出版者・発行元： American Chemical Society
DOI： 10.1021/acsami.8b01869 　

ISSN：1944-8252 1944-8244
Apolipoprotein L1 nephropathies: 2017 in review. 国際誌査読有り

Jeffrey B Kopp, Hila Roshanravan, Koji Okamoto

Current opinion in nephrology and hypertension　27　(3)　153-158　2018年5月

DOI： 10.1097/MNH.0000000000000399 　

ISSN：1062-4821

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PURPOSE OF REVIEW: To review publications relating to apolipoprotein L1 (APOL1) renal risk variants published 2017. RECENT FINDINGS: The study of APOL1 variants continues to be highly active; 24 articles published in 2017 were selected to highlight. These include clinical studies of kidney disease, kidney transplantation, hypertension, cardiovascular disease, and genetic diversity. Laboratory studies included APOL1 association with vesicle-associated membrane soluble N-ethylmaleimide-sensitive factor activating protein receptor protein and with soluble urokinase-type plasminogen activator receptor, mitochondrial dysfunction, endolysosomal dysfunction, and inflammasome activation. SUMMARY: Our understanding of the role of APOL1 genetic variants and the mechanisms for renal toxicity continues to deepen. It is not yet clear which pathways are most relevant to human disease, and so, the most relevant drug targets remain to be defined.
APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R. 国際誌査読有り

Koji Okamoto, Jason W Rausch, Hidefumi Wakashin, Yulong Fu, Joon-Yong Chung, Patrick D Dummer, Myung K Shin, Preeti Chandra, Kosuke Suzuki, Shashi Shrivastav, Avi Z Rosenberg, Stephen M Hewitt, Patricio E Ray, Eisei Noiri, Stuart F J Le Grice, Maarten Hoek, Zhe Han, Cheryl A Winkler, Jeffrey B Kopp

Communications biology　1　188-188　2018年

DOI： 10.1038/s42003-018-0188-2 　

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APOL1 risk alleles associate with chronic kidney disease in African Americans, but the mechanisms remain to be fully understood. We show that APOL1 risk alleles activate protein kinase R (PKR) in cultured cells and transgenic mice. This effect is preserved when a premature stop codon is introduced to APOL1 risk alleles, suggesting that APOL1 RNA but not protein is required for the effect. Podocyte expression of APOL1 risk allele RNA, but not protein, in transgenic mice induces glomerular injury and proteinuria. Structural analysis of the APOL1 RNA shows that the risk variants possess secondary structure serving as a scaffold for tandem PKR binding and activation. These findings provide a mechanism by which APOL1 variants damage podocytes and suggest novel therapeutic strategies.
Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney 査読有り

Koji Okamoto, Kenjiro Honda, Kent Doi, Tomoko Ishizu, Daisuke Katagiri, Takehiko Wada, Kenji Tomita, Takayasu Ohtake, Toyoji Kaneko, Shuzo Kobayashi, Masaomi Nangaku, Katsushi Tokunaga, Eisei Noiri

AMERICAN JOURNAL OF PATHOLOGY　185　(7)　1889-1898　2015年7月

DOI： 10.1016/j.ajpath.2015.03.025 　

ISSN：0002-9440

eISSN：1525-2191
シスプラチン急性腎障害における腸管由来GLP-1の効果

片桐大輔, 濱崎敬文, 土井研人, 岡本好司, 根岸康介, 南学正臣, 野入英世

日本腎臓学会誌　56　(3)　322-322　2014年5月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
siRNA delivery targeting to the lung via agglutination-induced accumulation and clearance of cationic tetraamino fullerene 査読有り

Kosuke Minami, Koji Okamoto, Kent Doi, Koji Harano, Eisei Noiri, Eiichi Nakamura

SCIENTIFIC REPORTS　4　4916　2014年5月

DOI： 10.1038/srep04916 　

ISSN：2045-2322
Protection of Glucagon-Like Peptide-1 in Cisplatin-Induced Renal Injury Elucidates Gut-Kidney Connection 査読有り

Daisuke Katagiri, Yoshifumi Hamasaki, Kent Doi, Koji Okamoto, Kousuke Negishi, Masaomi Nangaku, Eisei Noiri

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　24　(12)　2034-2043　2013年12月

DOI： 10.1681/ASN.2013020134 　

ISSN：1046-6673

eISSN：1533-3450
HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity. 査読有り

Shrivastav S, Zhang L, Okamoto K, Lee H, Lagranha C, Abe Y, Balasubramanyam A, Lopaschuk GD, Kino T, Kopp JB

Molecular endocrinology (Baltimore, Md.)　27　(9)　1564-1576　2013年9月

DOI： 10.1210/me.2012-1370 　

ISSN：0888-8809
Specific antibody in IV immunoglobulin for postsplenectomy sepsis 査読有り

Kensuke Nakamura, Kent Doi, Koji Okamoto, Syunnya Arai, Satoshi Ueha, Kouji Matsushima, Susumu Nakajima, Naoki Yahagi, Eisei Noiri

Critical Care Medicine　41　(8)　e163-e170　2013年8月

DOI： 10.1097/CCM.0b013e318287f1de 　

ISSN：0090-3493 1530-0293
Protein-coated nanocapsules via multilevel surface modification. Controlled preparation and microscopic analysis at nanometer resolution 査読有り

Koji Harano, Kosuke Minami, Eisei Noiri, Koji Okamoto, Eiichi Nakamura

CHEMICAL COMMUNICATIONS　49　(34)　3525-3527　2013年

DOI： 10.1039/c3cc40752g 　

ISSN：1359-7345
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor simvastatin ameliorates renal fibrosis through HOXA13-USAG-1 pathway 査読有り

Yoshifumi Hamasaki, Kent Doi, Koji Okamoto, Hideaki Ijichi, George Seki, Rui Maeda-Mamiya, Toshiro Fujita, Eisei Noiri

LABORATORY INVESTIGATION　92　(8)　1161-1170　2012年8月

DOI： 10.1038/labinvest.2012.71 　

ISSN：0023-6837
Inhibition of Glucose-Stimulated Insulin Secretion by KCNJ15, a Newly Identified Susceptibility Gene for Type 2 Diabetes 査読有り

Koji Okamoto, Naoko Iwasaki, Kent Doi, Eisei Noiri, Yasuhiko Iwamoto, Yasuko Uchigata, Toshiro Fujita, Katsushi Tokunaga

DIABETES　61　(7)　1734-1741　2012年7月

DOI： 10.2337/db11-1201 　

ISSN：0012-1797
A novel mechanism in maggot debridement therapy: protease in excretion/secretion promotes hepatocyte growth factor production 査読有り

Kenjiro Honda, Koji Okamoto, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Ryota Ikee, Hidekazu Moriya, Sumi Hidaka, Takayasu Ohtake, Kent Doi, Toshiro Fujita, Shuzo Kobayashi, Eisei Noiri

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY　301　(6)　C1423-C1430　2011年12月

DOI： 10.1152/ajpcell.00065.2011 　

ISSN：0363-6143
Common variation in GPC5 is associated with acquired nephrotic syndrome 査読有り

Koji Okamoto, Katsushi Tokunaga, Kent Doi, Toshiro Fujita, Hodaka Suzuki, Tetsuo Katoh, Tsuyoshi Watanabe, Nao Nishida, Akihiko Mabuchi, Atsushi Takahashi, Michiaki Kubo, Shiro Maeda, Yusuke Nakamura, Eisei Noiri

NATURE GENETICS　43　(5)　459-+　2011年5月

DOI： 10.1038/ng.792 　

ISSN：1061-4036
Serum biological antioxidant potential predicts the prognosis of hemodialysis patients. 国際誌

Tomoko Ishii, Takayasu Ohtake, Koji Okamoto, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Ryota Ikee, Hidekazu Moriya, Sumi Hidaka, Kent Doi, Eisei Noiri, Toshiro Fujita, Shuzo Kobayashi

Nephron. Clinical practice　117　(3)　c230-6　2011年

DOI： 10.1159/000320201 　

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BACKGROUND: It is well known that oxidative stress is enhanced in patients with end-stage renal disease. However, little is known about the relationship between serum antioxidant capacity and clinical outcome in hemodialysis (HD) patients. METHODS: We examined the relationship between serum biomarkers of oxidative stress and clinical outcomes including all-cause mortality, hospitalization rate and incidence of cardiovascular events in HD patients. As biomarkers of oxidative stress, we measured serum levels of coenzyme Q10 (CoQ10) and biological antioxidant potential (BAP). RESULTS: 108 patients were observed for 30 months as the follow-up periods. The survival group (n = 83) showed significantly higher BAP values compared with those in death groups (n = 25; p < 0.05). When serum BAP levels were divided into two groups by their median value, the group with higher BAP values had a better survival rate than that with lower BAP values on the Kaplan-Meier survival analysis (p = 0.05). Although serum levels of CoQ10 did not show any association with clinical outcomes, lower BAP was selected as an independent risk factor for all-cause mortality as well as the absence of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers therapy by age-adjusted Cox regression analysis. CONCLUSIONS: This study indicated that BAP could predict the prognosis of HD patients.
Acute tubular necrosis due to cutaneous contact with cresol 査読有り

Koji Okamoto, Eisei Noiri, Machiko Oka, Hidekazu Moriya, Takayasu Ohtake, Shuzo Kobayashi

BMJ Case Reports　2011　2011年
出版者・発行元： BMJ Publishing Group
DOI： 10.1136/bcr.08.2010.3213 　

ISSN：1757-790X
Neutrophil Elastase Contributes to Acute Lung Injury Induced by Bilateral Nephrectomy 査読有り

Tomoko Ishii, Kent Doi, Koji Okamoto, Mitsuru Imamura, Makoto Dohi, Kazuhiko Yamamoto, Toshiro Fujita, Eisei Noiri

AMERICAN JOURNAL OF PATHOLOGY　177　(4)　1665-1673　2010年10月

DOI： 10.2353/ajpath.2010.090793 　

ISSN：0002-9440
In vivo gene delivery by cationic tetraamino fullerene 査読有り

Rui Maeda-Mamiya, Eisei Noiri, Hiroyuki Isobe, Waka Nakanishi, Koji Okamoto, Kent Doi, Takeshi Sugaya, Tetsuro Izumi, Tatsuya Homma, Eiichi Nakamura

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　107　(12)　5339-5344　2010年3月

DOI： 10.1073/pnas.0909223107 　

ISSN：0027-8424
Identification of KCNJ15 as a Susceptibility Gene in Asian Patients with Type 2 Diabetes Mellitus 査読有り

Koji Okamoto, Naoko Iwasaki, Chisa Nishimura, Kent Doi, Eisei Noiri, Shinko Nakamura, Miho Takizawa, Makiko Ogata, Risa Fujimaki, Niels Grarup, Charlotta Pisinger, Knut Borch-Johnsen, Torsten Lauritzen, Annelli Sandbaek, Torben Hansen, Kazuki Yasuda, Haruhiko Osawa, Kishio Nanjo, Takashi Kadowaki, Masato Kasuga, Oluf Pedersen, Toshiro Fujita, Naoyuki Kamatani, Yasuhiko Iwamoto, Katsushi Tokunaga

AMERICAN JOURNAL OF HUMAN GENETICS　86　(1)　54-64　2010年1月

DOI： 10.1016/j.ajhg.2009.12.009 　

ISSN：0002-9297
No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis 査読有り

Sabine Vollstedt, Rika Yuliwulandari, Koji Okamoto, Luu Thi Lien, Naoto Keicho, Jecti Teguh Rochani, Riyani Wikaningrum, Katsushi Tokunaga

TUBERCULOSIS　89　(1)　71-76　2009年1月

DOI： 10.1016/j.tube.2008.09.006 　

ISSN：1472-9792
Genome study of kidney disease in the age of post genome-sequencing 査読有り

Kent Doi, Koji Okamoto, Katsushi Tokunaga, Toshiro Fujita, Eisei Noiri

Endocrine, Metabolic and Immune Disorders - Drug Targets　8　(3)　173-183　2008年9月

DOI： 10.2174/187153008785700136 　

ISSN：1871-5303
透析患者における下肢閉塞性動脈硬化症無侵襲診断法について

岡本好司, 岡真知子, 真栄里恭子, 真野勉, 池江亮太, 守矢秀和, 大竹剛靖, 小林修三

脈管学　46　(6)　829-835　2006年12月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

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維持透析患者で下肢切断術未施行の140例280肢(男性94例、女性46例、平均67.2±10.2歳)を対象に足関節/上腕血圧比(ABPI)及び皮膚灌流圧(SPP)測定を行い、更にこのうち36例72肢(男性25例、女性11例、平均61.9±12.7歳)に対して多検出器列型CTを施行し、透析患者における末梢動脈塞栓症(PAOD)の病変レベル毎のABPIとSPPの検出精度について検討した。ABPIのカットオフ値0.9未満における感度は29.9%、特異度は100%、SPPはカットオフ値50mmHgで感度、特異度は各々84.9%、76.9%であり、この値による全患者のPAOD罹患率は41.4%であった。ABPIの感度は非常に低値であるが、SPPは透析患者においてもPAODのスクリーニング検査として非常に有用であることが示された。
Peripheral arterial occlusive disease is more prevalent in patients with hemodialysis: Comparison with the findings of multidetector-row computed tomography 査読有り

Koji Okamoto, Machiko Oka, Kyoko Maesato, Ryota Ikee, Tsutomu Mano, Hidekazu Moriya, Takayasu Ohtake, Shuzo Kobayashi

AMERICAN JOURNAL OF KIDNEY DISEASES　48　(2)　269-276　2006年8月

DOI： 10.1053/j.ajkd.200604.075 　

ISSN：0272-6386
F-18-fluorodeoxyglucose positron emission tomography in a case retroperitoneal fibrosis 査読有り

Aiko Sakamoto, Koji Okamoto, Nobukazu Ishizaka, Kazuaki Tejima, Yasunobu Hirata, Ryozo Nagai

INTERNATIONAL HEART JOURNAL　47　(4)　645-650　2006年7月

DOI： 10.1536/ihj.47.645 　

ISSN：1349-2365
Ticlopidine-induced lupus with renal involvement 査読有り

Takayasu Ohtake, Shuzo Kobayashi, Koji Okamoto, Machiko Oka, Kyoko Maesato, Takeo Yasu, Hidekazu Moriya

NEPHROLOGY DIALYSIS TRANSPLANTATION　21　(7)　1992-1993　2006年7月

DOI： 10.1093/ndt/gfl028 　

ISSN：0931-0509
LDL-apheresis reduces P-selectin, CRP and fibrinogen - Possible important implications for improving atherosclerosis 査読有り

S Kobayashi, M Oka, H Moriya, K Maesato, K Okamoto, T Ohtake

THERAPEUTIC APHERESIS AND DIALYSIS　10　(3)　219-223　2006年6月

DOI： 10.1111/j.1744-9987.2006.00332.x 　

ISSN：1744-9979
Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice 査読有り

K Doi, K Okamoto, K Negishi, Y Suzuki, A Nakao, T Fujita, A Toda, T Yokomizo, Y Kita, Y Kihara, S Ishii, T Shimizu, E Noiri

AMERICAN JOURNAL OF PATHOLOGY　168　(5)　1413-1424　2006年5月

DOI： 10.2353/ajpath.2006.050634 　

ISSN：0002-9440
Efficacy of darbepoetin in doxorubicin-induced cardiorenal injury in rats. 国際誌査読有り

Noiri E, Nagano N, Negishi K, Doi K, Miyata S, Abe M, Tanaka T, Okamoto K, Hanafusa N, Kondo Y, Ishizaka N, Fujita T

Nephron. Experimental nephrology　104　(1)　e6-e14　2006年

DOI： 10.1159/000093258 　

ISSN：1660-8151

eISSN：1660-2129
PMX-DHP エンドトキシン吸着療法(PMX)の効果判定,予後規定因子に関する考察

岡本好司, 真栄里恭子, 守矢英和, 大竹剛靖, 小林修三

ICUとCCU　28　(別冊)　S200-S202　2004年2月
出版者・発行元：医学図書出版(株)
ISSN：0389-1194

詳細を見る詳細を閉じる

エンドトキシン吸着療法(PMX)を施行された35症例について,ベッドサイドでモニター可能な効果判定・予後規定因子を検討した.生存24例,死亡11例であった.PMX施行前の白血球数に有意差を認め,生存例平均10800μl,死亡例平均6200μlであった.また,SOFA score 9以上(Fisher's testによる)では死亡率が高かった.DOA投与量は死亡例で有意に多かった.平均血圧/脈拍比(MB/P値)は生存例で有意に高値であった.このほか,PMX施行前に白血球増多をみない症例,MB/P値<0.7の症例では,PMX施行後,症状が改善されて生存している場合もあり,このような症例にもPMXが有用であると思われた

︎全件表示 ︎最初の5件までを表示

MISC 19

置換液の変更で血漿交換時のアレルギー反応を回避しえた視神経脊髄炎スペクトラム障害の1例

荒井啓太, 光澤志緒, 古川暁子, 岡本好司, 高井良樹, 西山修平, 鈴木康太郎, 檜森紀子, 宮崎真理子, 中澤徹, 青木正志

臨床神経学　65　(12)　919-919　2025年12月
出版者・発行元： (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
分娩時大量出血により発症した妊娠関連血栓性微小血管症(TMA)の一例

吉田舞, 石塚悠奨, 木之村聡介, 野口雄司, 金沙織, 菊地晃一, 大江佑治, 岡本好司, 豊原敬文, 宮崎真理子, 田中哲洋

日本腎臓学会誌(Web)　66　(6-E)　2024年

ISSN： 1884-0728
非典型的な臨床経過と腎病理を呈した多発血管炎性肉芽腫症

木之村聡介, 豊原敬文, 白井剛志, 秋保真穂, 菊地晃一, 牧野塁, 吉田舞, 大江佑治, 岡本好司, 長澤将, 宮崎真理子, 佐藤博, 藤井博司, 田中哲洋

日本腎臓学会誌(Web)　66　(6-E)　2024年

ISSN： 1884-0728
医療倫理コンサルテーションチームによる腎代替療法の継続/中止の検討

藤倉恵美, 小島慶恵, 吉田舞, 小山千佳, 千葉祐貴, 岡本好司, 長澤将, 宮崎真理子

日本透析医学会雑誌　53　(Suppl.1)　370-370　2020年10月
出版者・発行元： (一社)日本透析医学会
ISSN： 1340-3451

eISSN： 1883-082X
血胸を契機に発見された縦隔内異所性副甲状腺腺腫の一例

千葉祐貴, 小島慶恵, 吉田舞, 大江佑治, 岡本好司, 藤倉恵美, 長澤将, 宮崎真理子, 岡田克典

日本透析医学会雑誌　53　(Suppl.1)　555-555　2020年10月
出版者・発行元： (一社)日本透析医学会
ISSN： 1340-3451

eISSN： 1883-082X
適切な分娩計画により、安全に出産をした長期血液透析患者の一例

吉田舞, 藤倉恵美, 竹内沙永子, 岡本好司, 長澤将, 中道崇, 加藤政子, 植田卓志, 齋藤昌利, 宮崎真理子, 伊藤貞嘉

日本透析医学会雑誌　52　(Suppl.1)　787-787　2019年5月
出版者・発行元： (一社)日本透析医学会
ISSN： 1340-3451

eISSN： 1883-082X
Genetic Variants in the Lanosterol Synthase Gene Are Associated with Type 2 Diabetes

Naoko Iwasaki, Koji Okamoto, Kenjiro Honda, Akira Saito, Miho Takizawa, Makiko Ogata, Kazuki Yasuda, Torben Hansen, Oluf Pedersen, Kyong Soo Park, Weiping Jia, Cheng Hu, Yasuko Uchigata, Katsushi Tokunaga

DIABETES　64　A460-A460　2015年6月

ISSN： 0012-1797

eISSN： 1939-327X
LSS多型は、内臓肥満やインスリン抵抗性を介して糖尿病発症に関連する

岡本好司, 山下徹志, 本田謙次郎, 蔵野信, 塚本和久, 野入英世, 南学正臣, 門脇孝, 岩崎直子, 徳永勝士

肥満研究　19　(Suppl.)　159-159　2013年9月
出版者・発行元： (一社)日本肥満学会
ISSN： 1343-229X
水溶性フラーレン誘導体を用いた肺選択的siRNAデリバリー

南皓輔, 原野幸治, 岡本好司, 野入英世, 土井研人, 中村栄一

日本化学会講演予稿集　93rd　(3)　2013年

ISSN： 0285-7626
遺伝・ゲノム学腎領域におけるゲノムワイド関連解析

岡本好司, 野入英世

医学のあゆみ　240　(12)　983-984　2012年3月
出版者・発行元：医歯薬出版(株)
ISSN： 0039-2359
カチオン性アミノフラーレンを用いたsiRNAデリバリー

南皓輔, 岡本好司, 野入英世, 原野幸治, 中村栄一

日本DDS学会学術集会プログラム予稿集　28th　2012年
腎臓内科学ネフローゼ症候群とGlypican-5多型の関連

岡本好司, 野入英世

医学のあゆみ　240　(2)　181-182　2012年1月
出版者・発行元：医歯薬出版(株)
ISSN： 0039-2359
Common variation in lanosterol synthase gene predispose to type 2 diabetes

N. Iwasaki, K. Okamoto, E. Noiri, M. Takizawa, M. Ogata, T. Hansen, O. Pedersen, K. Park, Y. Iwamoto, K. Tokunaga

DIABETOLOGIA　54　S125-S126　2011年9月

ISSN： 0012-186X
糖尿病・内分泌代謝学アジア集団における新規2型糖尿病感受性遺伝子KCNJ15

岡本好司

医学のあゆみ　234　(11)　1058-1059　2010年9月
出版者・発行元：医歯薬出版(株)
ISSN： 0039-2359
Effect of Promoter Region Polymorphisms in N-Acetyltransferase 2 (NAT2) Phenotype

Rika Yuliwulandari, Koji Okamoto, Dharma Permana, Katsushi Tokunaga

DRUG METABOLISM REVIEWS　42　156-157　2010年8月

ISSN： 0360-2532
Simvastatin ameliorates renal fibrosis via suppressing uterine sensitization-associated gene-1 (USAG-1), a BMP-7 antagonist, in mouse adenine-induced tubulointerstitial injury model

Yoshifumi Hamasaki, Koji Okamoto, Kent Doi, Toshiro Fujita, Eisei Noiri

FASEB JOURNAL　24　2010年4月

ISSN： 0892-6638
Association study based on the genome wide linkage results revealed two genes on chromosome 21 in type 2 diabetic subjects in Japanese

Naoko Iwasaki, Koji Okamoto, Shinko Nakamura, Makiko Ogata, Katsushi Tokunaga, Naoyuki Kamatani, Yasuhiko Iwamoto

DIABETES　56　A645-A645　2007年6月

ISSN： 0012-1797
アドリアマイシンによる心腎症候群モデルに対するDarbepoetinの効果

野入英世, 永野伸郎, 根岸康介, 土井研人, 宮田そのえ, 阿部めぐみ, 田中珠美, 岡本好司, 花房規男, 近藤靖司, 石坂信和, 藤田敏郎

日本腎臓学会誌　48　(3)　283-283　2006年4月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
CLINICOPATHOLOGICAL STUDY OF RENAL DISEASES WITH MILD PROTEINURIA

Koji Okamoto, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Takayasu Ohtake, Shuzo Kobayashi

NEPHROLOGY　10　A159-A160　2005年6月

ISSN： 1320-5358

︎全件表示 ︎最初の5件までを表示

書籍等出版物 7

The Concise Manual of Apheresis Therapy (second edition)

Koji OKAMOTO

Springer　2026年

ISBN: 9789819548637
アフェレシス療法ポケットマニュアル(第3版)

野入, 英世, 土井, 研人

医歯薬出版　2025年7月

ISBN: 9784263200520
CRRT療法ポケットマニュアル第2版

岡本好司

医歯薬出版　2015年
The Concise Manual of Apheresis Therapy

岡本好司

Springer　2014年
CRRT療法ポケットマニュアル

岡本好司

医歯薬出版　2011年
アフェレーシス療法ポケットマニュアル第2版

岡本好司

医歯薬出版　2011年
アフェレーシス療法ポケットマニュアル

岡本好司

医歯薬出版　2010年

︎全件表示 ︎最初の5件までを表示

講演・口頭発表等 20

Effective Removal of Cytokines Using Polyacrylonitrile (AN69) Membranes Compared to Polysulfone (PS) and Polymethyl Methacrylate (PMMA) Membranes During the Initiation of Hemodialysis

Koji Okamoto

the 23rd Asian Pacific Congress of Nephrology (APCN 2025)　2025年12月6日
LSS多型は、内臓肥満やインスリン抵抗性を介して糖尿病発症に関連する

岡本好司, 山下徹志, 本田謙次郎, 蔵野信, 塚本和久, 野入英世, 南学正臣, 門脇孝, 岩崎直子, 徳永勝士

肥満研究　2013年9月
透析患者における末梢動脈硬化症と予後の検討

岡本好司, 野入英世, 藤田敏郎, 本田謙次郎, 石岡邦啓, 岡真知子, 池江亮太, 日高寿美, 大竹剛靖, 小林修三

日本透析医学会雑誌　2009年5月
高ミオグロビン血症に対するβ2ミクログロブリン吸着カラムの有効性の検討

岡本好司, 浜崎敬文, 野入英世, 藤田敏郎, 本田謙次郎, 岡真知子, 池江亮太, 守矢英和, 日高寿美, 大竹剛靖, 小林修三

日本腎臓学会誌　2009年4月
透析患者の循環器合併症治療の最前線透析患者の末梢動脈疾患の早期発見と治療

岡本好司, 守矢英和, 大竹剛靖, 野入英世, 小林修三

医工学治療　2008年4月
関連解析によって得られた21番染色体上の2型糖尿病の感受性遺伝子

岡本好司, 岩崎直子, 西村知紗, 中村新子, 尾形真規子, 藤巻理沙, 鎌谷直之, 岩本安彦, 徳永勝士

糖尿病　2007年4月
糖尿病合併透析患者の下肢末梢動脈狭窄病変の早期発見各種検査成績の感度の比較および危険因子

岡本好司, 池江亮太, 守矢英和, 大竹剛靖, 浜野久美子, 小林修三

糖尿病　2006年4月
Severity of interstitial injury and clinical manifestations in nephrotic syndrome

Koji Okamoto

(18th International) 3rd World congress of Nephrology　2005年6月26日
透析日/非透析日の違いによる睡眠時無呼吸・睡眠障害の評価

岡本好司, 黒岩園子, 加賀谷範芳, 田井香織, 岡真知子, 真栄里恭子, 守矢英和, 高橋幸成, 大竹剛靖, 小林修三

日本腎臓学会誌　2005年5月
透析患者における閉塞性動脈硬化症に対する非侵襲的検査方法の比較

岡本好司, 岡真知子, 真栄里恭子, 守矢英和, 大竹剛靖, 小林修三, 種山かよ子, 高室昌司

日本透析医学会雑誌　2005年5月
ステロイド治療が奏功し透析を離脱しえた,尿細管間質病変が主体のMPO-ANCA関連腎炎の1例

岡本好司, 岡真知子, 真栄里恭子, 守矢英和, 大竹剛靖, 小林修三

日本腎臓学会誌　2004年8月
軽微な蛋白尿を呈する症例の腎生検組織所見とその後の臨床経過の検討

岡本好司, 真栄里恭子, 守矢英和, 麻生邦子, 大竹剛靖, 小林修三

日本腎臓学会誌　2004年4月
糸球体血管極周囲を中心に間質の細胞浸潤を伴ったネフローゼ症候群の一例

岡本好司, 真栄里恭子, 守矢英和, 大竹剛靖, 小林修三

腎炎症例研究　2004年2月

詳細を見る詳細を閉じる

41歳女.15歳時にネフローゼ症候群を初発し,3ヵ月間入院加療を受けた.27歳時に再発し,巣状糸球体硬化症(FGS)の診断でステロイド内服治療を1年間受けた.3週間前から尿量減少,体重増加,浮腫があり受診した.低蛋白血症,低アルブミン血症,蛋白尿などを認め,臨床的には微小変化型ネフローゼ症候群と思われた.腎生検では間質細胞浸潤,上皮細胞剥離,メサンギウム領域へのIgM沈着などを認めFGSの可能性が高いと考えられたが,FGSの典型的所見である分節状糸球体硬化は確認できず,間質性腎炎などの可能性も示唆された
Tar Sequence (Double-Stranded-RNA)-PKR Activation Mediated Podocyte Injury with HIV-1 Infection

Koji Okamoto

Kidney week 2019　2019年11月8日
APOL1 mRNA Is Partially Retained in the Nucleus and Is Associated with Increased Levels of Phosphorylated Protein Kinase R

Koji Okamoto

Kidney week 2016　2016年11月17日
Biological Mechanisms Underlying Kidney Disease Risk in African Americans: APOL1 mRNA Renal Risk Variants Activate Protein Kinase R (PKR) and Reduce Cellular Protein Synthesis

Koji Okamoto

11th International Podocyte Conference　2016年4月4日
HIV Vpr antagonizes mineralocorticoid receptor activity, explaining renal salt wasting

Koji Okamoto

Kidney week 2015　2015年11月5日
APOL1 mRNA renal risk variants activate protein kinase R and reduce cell protein synthesis in vitro and increase susceptibility to proteinuria in vivo

Koji Okamoto

Kidney week 2014　2014年11月15日
APOL1 encodes a novel miRNA that induces PKR, and miRNA levels are increased in plasma exosomes from G1 homozygous individuals

Koij OKAMOTO

Kidney week 2013　2013年11月8日
FGF Signaling Predisposes Podocyte Injury in Diabetic Nephropathy (DMN)

Koji Okamoto

Kidney week 2011　2011年11月12日

︎全件表示 ︎最初の5件までを表示

産業財産権 3

ネフローゼ症候群の検査方法、並びにネフローゼ症候群の予防又は治療薬およびそのスクリーニング方法

岡本好司

産業財産権の種類: 特許権
糖尿病発症及び／又は進展リスクの判定方法

岡本好司

産業財産権の種類: 特許権
バスキュラーアクセスカテーテル

岡本好司

産業財産権の種類: 特許権

共同研究・競争的資金等の研究課題 7

深層学習を使った腎糸球体病変の組織診断定量化アルゴリズムの開発

岡本好司, 小島要, 志藤光介

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2025年4月1日～ 2028年3月31日
新規ChREBP阻害薬の標的遺伝子に対するPerturbシークエンスを用いたNAFLDの病態制御

菅原明, 岩渕好治, 横山敦, 井上淳, 岡本好司

2024年6月28日～ 2026年3月31日
糖質応答転写因子ChREBPを標的とした糖尿病性腎症の病態解明・新規創薬

菅原明, 岩渕好治, 横山敦, 岡本好司

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2020年4月～ 2023年3月

詳細を見る詳細を閉じる

我々は当該年度に以下の実験を遂行した。１）糖尿病性腎症（DN）の発症・増悪におけるChREBPの関与・作用機構の解明：A) CRISPR/Cas9システムを用いて作成したChREBPノックアウトマウスからRNAを抽出してRNAシークエンスに供する準備を進めている。B）東北大学医学部倫理委員会にて承認を得たことから、東北大学病院腎・高血圧・内分泌科の腎生検組織からのRNA抽出・RNAシークエンスに向けて、DNならびに非DN検体の準備を進めている。２）D532のDN改善効果の機序解明および実用化・臨床応用に向けた構造最適化：A）D532の一端を伸長して末端をビオチン化することにより作成したD532プローブを用いて、アビジン‐ビオチン反応を利用したアフィニティ精製・質量分析にてD532の標的因子の同定を進めた結果、ChREBP自身がD532の標的因子であることが明らかとなった。B）ChIPアッセイの結果、D532がChREBPのDNAへの結合を抑制することが認められた。本結果から、D532が高血糖依存性のChREBP転写活性をDNA結合レベルで抑制することが明らかとなった。C）D532はChREBPの核内移行には影響を及ぼさないことが明らかとなった。D）疎水性であるD532をPMB30Wにてミセル化することにより水溶化が出来ることが明らかとなった。本成果により、今後のD532を用いた非臨床試験・臨床試験に向けて大きく前進できるものと期待される。
深層学習を使った腎生検組織診断AIの開発

近松陽一郎、岡本好司

提供機関：Japan Kidney Association (Miyagi pref)

制度名：Research grant-support

研究機関：Tohoku University

2021年4月～ 2022年3月
糖尿病性腎臓病のAI画像診断と網羅発現解析を使った新規病理診断法の開発

岡本好司

提供機関：Gonryo for the promotion of medical science

制度名：Anzai research grand

研究機関：Tohoku University

2020年4月～ 2021年3月
APOL1遺伝子多型の糸球体障害発症機序競争的資金

岡本好司

提供機関：Japan Society for the Promotion of Science

制度名：Overseas Research Fellowships

2012年6月～ 2014年5月
ネフローゼ症候群における蛋白尿発症機構への遺伝学的アプローチと機能的解明競争的資金

野入英世

提供機関：Japan Society for the Promotion of Science

制度名：Grant-in-Aid for Scientific Research (B)

2012年4月～ 2014年3月

︎全件表示 ︎最初の5件までを表示

社会貢献活動 1

CROの担当者への講義

2008年4月～ 2009年3月

メディア報道 1

日経BP社医学アドバイザー

日経BP

2018年8月1日

メディア報道種別: 会誌・広報誌