東北大学研究者紹介 - Thyreau Benjamin Guillaume Julien

研究者詳細

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日本語 English

顔写真

テイロー　バンジヤマン　ギヨーム　ジユリアン

Thyreau Benjamin Guillaume Julien

所属

加齢医学研究所　脳科学研究部門　臨床加齢医学研究分野

職名

助教

学位

博士（医学）（東北大学）
MASTER OF SCIENCES AND TECHNOLOGIES(パリ第6大学及びパリ第7大学)

researchmap

https://researchmap.jp/bthyreau

J-GLOBAL ID

201801002049479418

研究キーワード 1

MRI Deep-Learning Machine-Learning Neuroimaging

研究分野 1

情報通信 / 生命、健康、医療情報学 /

論文 78

Deep learning-derived magnetic resonance imaging masseter muscle volume is associated with oral impairment and cognitive frailty in older Japanese adults

Liying Chen, Benjamin Thyreau, Yasuko Tatewaki, Yingxu Liu, Ken Takeda, Taizen Nakase, Shigeyuki Nakaji, Tatsuya Mikami, Yoshihiro Tamura, Wataru Kobayashi, Koichi Murashita, Toshiharu Ninomiya, Yasuyuki Taki

Experimental Gerontology　224　113302-113302　2026年10月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.exger.2026.113302 　

ISSN：0531-5565
From the plate to the brain: associations between dietary patterns and reduced dementia prevalence and white matter lesions in older Japanese adults. 国際誌

Liying Chen, Yasuko Tatewaki, Benjamin Thyreau, Kazuhiro Uchida, Hikari Iki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Moeko Noguchi-Shinohara, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Yasuyuki Taki

GeroScience　2025年7月29日

DOI： 10.1007/s11357-025-01791-7 　
Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

Naoki Ishizuka, Hiroshi Akasaka, Mitsunobu Sato, Yuriko Sato, Kazuki Hosokawa, Junko Takahashi, Hisashi Yonezawa, Yasuo Terayama, Tomoyuki Ohara, Takanori Honda, Mao Shibata, Jun Hata, Yasuko Tatewaki, Yasuyuki Taki, Tatsuya Mikami, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Tetsuya Maeda, Toshiharu Ninomiya, Mao Shibata, Takanori Honda, Jun Hata, Tomoyuki Ohara, Masato Akiyama, Tetsuya Maeda, Naoki Ishizuka, Hiroshi Akasaka, Junko Takahashi, Hisashi Yonezawa, Yasuo Terayama, Yasuyuki Taki, Yasuko Tatewaki, Benjamin Thyreau, Tatsuya Mikami, Shigeyuki Nakaji, Koichi Murashita, Kaori Sawada, Shintaro Yokoyama, Kenjiro Ono, Moeko Noguchi-Shinohara, Kazuo Iwasa, Sohshi Yuki-Nozaki, Masahito Yamada, Masaru Mimura, Shogyoku Bun, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Kenji Nakashima, Yasuyo Fukada, Hisanori Kowa, Toshiya Nakano, Kenji Wada, Masafumi Kishi, Jun-ichi Iga, Tomoki Ozaki, Ayumi Tachibana, Yuta Yoshino, Shu-ichi Ueno, Minoru Takebayashi, Naoto Kajitani, Yusuke Miyagawa, Tomohisa Ishikawa, Seiji Yuki, Ryuji Fukuhara, Asuka Koyama, Mamoru Hashimoto, Manabu Ikeda, Yoshihiro Kokubo, Kazuhiro Uchida, Midori Esaki, Hisako Yoshida, Kaori Muto, Yusuke Inoue, Izen Ri, Yukihide Momozawa, Chikashi Terao, Michiaki Kubo, Yutaka Kiyohara

Scientific Reports　15　(1)　2025年6月4日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41598-025-04659-0 　

eISSN：2045-2322
The neural basis of coping strategies for boredom and their association with creativity

Sugiko Hanawa, Takayuki Nozawa, Motoaki Sugiura, Rui Nouchi, Ryoichi Yokoyama, Benjamin Thyreau, Yuka Kotozaki, Tsuyoshi Araki, Ryuta Kawashima

Thinking Skills and Creativity　101794-101794　2025年2月

DOI： 10.1016/j.tsc.2025.101794 　

ISSN：1871-1871
Beneficial Effects of a 26-Week Exercise Intervention Using IoT Devices on Cognitive Function and Health Indicators

Keishi Soga, Akira Higuchi, Naoki Tomita, Koki Kobayashi, Hiroki Kataoka, Aizhan Imankulova, Carlos Salazar, Benjamin Thyreau, Shota Nakamura, Yuki Tsushita, Akiyoshi Uchiyama, Yasuyuki Taki

Journal of Science in Sport and Exercise　2025年1月20日

DOI： 10.1007/s42978-024-00321-9 　

ISSN：2096-6709

eISSN：2662-1371
Influence of intergenerational social mobility on brain structure and global cognition: findings from the Whitehall II study across 20 years. 国際誌

Yingxu Liu, Benjamin Thyreau, Yuehua Cui, Ye Zhang, Yasuko Tatewaki, Yasuyuki Taki

Age and ageing　53　(10)　2024年10月1日

DOI： 10.1093/ageing/afae221 　
Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function. 国際誌

Ayano Shima, Moeko Noguchi-Shinohara, Shutaro Shibata, Yuta Usui, Yasuko Tatewaki, Benjamin Thyreau, Jun Hata, Tomoyuki Ohara, Takanori Honda, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Hisao Nishijo, Toshiharu Ninomiya, Kenjiro Ono

npj aging　10　(1)　39-39　2024年9月9日

DOI： 10.1038/s41514-024-00164-2 　
Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)

benjamin thyreau

SCIENTIFIC REPORTS　2024年

DOI： 10.1038/S41598-024-57922-1 　
Longitudinal loneliness changes are associated with cognitive decline and brain structure alterations: evidence from the Whitehall II cohort study

benjamin thyreau

ALZHEIMERS & DEMENTIA　2024年

DOI： 10.1002/ALZ.084884 　
Masseter muscle volume measured by MRI correlated with cognitive function in a memory clinic

Michiho Muranaka, Yasuko Tatewaki, Benjamin Thyreau, Maya Sakamoto, Yumi Takano, Shuzo Yamamoto, Naoki Tomita, Taizen Nakase, Yasuyuki Taki

Alzheimer's & Dementia　19　(S15)　2023年12月25日
出版者・発行元： Wiley
DOI： 10.1002/alz.075877 　

ISSN：1552-5260

eISSN：1552-5279

詳細を見る詳細を閉じる

Abstract Background “Oral frailty” which indicates a decline in oral function, has been focused on the fact that it can also affect cognitive function in the elderly population. Although Several studies have been attempted for establishing the utility of the cross‐sectional area or volume of masticatory muscles as objective indices reflecting oral frailty, no report has examined the relationship between masticatory muscles volume and cognitive function in detail. In this study, we aimed to clarify the relationship between size of masseter muscle, one of major masticatory muscles, and cognitive function in the elderly. Method A total of 349 subjects (mean age 77.3 +/‐ 9.2 years, 126 males and 223 females, 58 with subjective cognitive impairment, 88 with mild cognitive impairment, and 203 with dementia), who visited the Memory clinic of Tohoku University Hospital with a chief complaint of forgetfulness by March 2018 were included. Using 3D T1‐weighted images acquired on a 3‐Tesla MRI system, the bilateral masseter muscle cross‐sectional area was automatically calculated for all subjects using a custom deep‐learning image‐processing model trained on a subset of subjects to identify the relevant muscles and consistent section. Then, partial correlations with the MMSE score were conducted, adjusting for age and gender. Result The mean left and right masseter muscle cross‐sectional area are 399.3±84.7mm² in subjective cognitive impairment, 387.9±106.5 mm² in mild cognitive impairment, and 355.1±88.4 mm² in dementia, respectively (p < 0.01). Adjusted for age and sex, they showed a significant correlation with MMSE (R = 0.151, p < 0.01). For post‐hoc stratified analysis, there was a significant correlation between mean masseter muscle cross‐sectional area and MMSE with female patients (R = 0.049, p < 0.05), whereas no correlation with male patients after adjusted age (R = 0.025, p > 0.05). Conclusion Our result revealed that the masseter muscle cross‐sectional area obtained from MRI may be related to cognitive function in the patients with complaint of forgetfulness. Therefore the masticatory function may reflect cognitive function in the elderly who are vulnerable in their memory, and the cross‐sectional area of masseter muscle based on MRI could be a potential indicator for predicting dementia risk.
Association between Gray and White Matter Lesions and Its Involvement in Clinical Symptoms of Alzheimer's-Type Dementia. 国際誌

Taizen Nakase, Benjamin Thyreau, Yasuko Tatewaki, Naoki Tomita, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

Journal of clinical medicine　12　(24)　2023年12月12日

DOI： 10.3390/jcm12247642 　
白質病変の定量化による日本人大規模高齢者集団の食事パターンと認知症に関する研究

陳俐穎, 舘脇康子, Thyreau Benjamin, 内田和宏, 壹岐ひかり, 中瀬泰然, 中路重之, 前田哲也, 野口もえ子[篠原], 三村將, 中島健二, 伊賀淳一, 竹林実, 二宮利治, 瀧靖之

Dementia Japan　37　(4)　666-666　2023年10月
出版者・発行元： (一社)日本認知症学会
ISSN：1342-646X
Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons. 国際誌

Ayumi Tachibana, Jun-Ichi Iga, Yasuko Tatewaki, Benjamin Thyreau, Hongkun Chen, Tomoki Ozaki, Taku Yoshida, Yuta Yoshino, Hideaki Shimizu, Takaaki Mori, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Minoru Takebayashi, Toshiharu Ninomiya, Shu-Ichi Ueno

Journal of geriatric psychiatry and neurology　37　(1)　8919887231195235-8919887231195235　2023年8月3日

DOI： 10.1177/08919887231195235 　
Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background 査読有り

JMA Journal　6　(3)　246-264　2023年7月

DOI： 10.31662/jmaj.2022-0220 　

ISSN：2433-328X

eISSN：2433-3298
Impact of atrial fibrillation on the cognitive decline in Alzheimer's disease. 国際誌

Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Hayato Odagiri, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

Alzheimer's research & therapy　15　(1)　15-15　2023年1月13日

DOI： 10.1186/s13195-023-01165-1 　
A longitudinal resource for population neuroscience of school-age children and adolescents in China

benjamin thyreau

SCIENTIFIC DATA　2023年

DOI： 10.1038/S41597-023-02377-8 　
Association between cortical lesions and white matter lesions in clinical symptoms of Alzheimer's disease

benjamin thyreau

JOURNAL OF THE NEUROLOGICAL SCIENCES　2023年

DOI： 10.1016/J.JNS.2023.121431 　
Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease. 国際誌

Ye Zhang, Yasuko Tatewaki, Taizen Nakase, Yingxu Liu, Naoki Tomita, Benjamin Thyreau, Haixia Zheng, Michiho Muranaka, Yumi Takano, Tatsuo Nagasaka, Yasuyuki Taki

Frontiers in aging neuroscience　15　1227325-1227325　2023年

DOI： 10.3389/fnagi.2023.1227325 　
Impact of constipation on progression of Alzheimer's disease: A retrospective study. 国際誌

Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Tatsushi Mutoh, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

CNS neuroscience & therapeutics　28　(12)　1964-1973　2022年12月

DOI： 10.1111/cns.13940 　
MRI画像を用いて測定した咬筋断面積と物忘れ患者の認知機能の相関に関する検討

村中美千帆, 舘脇康子, Benjamin Thyreau, 阪本真弥, 高野由美, 山本修三, 冨田尚希, 中瀬泰然, 瀧靖之

老年精神医学雑誌　33　(増刊II)　265-265　2022年11月
出版者・発行元： (株)ワールドプランニング
ISSN：0915-6305
MRI画像を用いて測定した咬筋断面積と物忘れ患者の認知機能の相関に関する検討

村中美千帆, 舘脇慶子, Benjamin Thyreau, 阪本真弥, 高野由美, 山本修三, 冨田尚希, 中瀬泰然, 瀧靖之

Dementia Japan　36　(4)　761-761　2022年10月
出版者・発行元： (一社)日本認知症学会
ISSN：1342-646X
深層学習によるMRI画像からの咬筋測定プログラム開発及び疫学的意義に関する初期検討

武田研, 舘脇康子, Benjamin Thyreau, 村中美千帆, 阪本真弥, 二宮利治, 瀧靖之

Dementia Japan　36　(4)　779-779　2022年10月
出版者・発行元： (一社)日本認知症学会
ISSN：1342-646X
緑内障患者の眼科指標と脳海馬体積との関連に関する検討

山田晃生, 舘脇康子, 面高宗子, 松平泉, Benjamin Thyreau, 瀧靖之, 中澤徹

日本緑内障学会抄録集　33回　86-86　2022年9月
出版者・発行元：日本緑内障学会
Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort 国際誌

Benjamin Thyreau, Yasuko Tatewaki, Liying Chen, Yuji Takano, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Moeko Noguchi-Shinohara, Masaru Mimura, Kenji Nakashima, Takaaki Mori, Minoru Takebayashi, Toshiharu Ninomiya, Yasuyuki Taki

HUMAN BRAIN MAPPING　43　(13)　3998-4012　2022年9月

DOI： 10.1002/hbm.25899 　

ISSN：1065-9471

eISSN：1097-0193
Association of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study. 国際誌

Moeko Noguchi-Shinohara, Kenjiro Ono, Sohshi Yuki-Nozaki, Kazuo Iwasa, Masami Yokogawa, Kiyonobu Komai, Benjamin Thyreau, Yasuko Tatewaki, Yasuyuki Taki, Mao Shibata, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Masahito Yamada

Scientific reports　12　(1)　12129-12129　2022年8月1日

DOI： 10.1038/s41598-022-16190-7 　
Impact of Catheter Ablation on Brain Microstructure and Blood Flow Alterations for Cognitive Improvements in Patients with Atrial Fibrillation: A Pilot Longitudinal Study. 国際誌

Yasuko Tatewaki, Tatsushi Mutoh, Hirokazu Sato, Akiko Kobayashi, Tomoko Totsune, Benjamin Thyreau, Atsushi Sekiguchi, Taizen Nakase, Tetsuo Yagi, Yasuyuki Taki

Journal of clinical medicine　11　(15)　2022年7月26日

DOI： 10.3390/jcm11154346 　
【あなたはAI好きですか?】BrainSuite(ブレーンスイート) 脳ドック等で簡便に利用できるAI画像解析サービスの紹介

樋口彰, Thyreau Benjamin, 瀧靖之

Rad Fan　20　(7)　45-48　2022年6月
出版者・発行元： (株)メディカルアイ
ISSN：1348-3498
アルツハイマー型認知症の進行に影響する心房細動についての検討

中瀬泰然, 舘脇康子, Thyreau Benjamin, 武藤達士, 冨田尚希, 山本修三, 高野由美, 村中美千帆, 瀧靖之

日本老年医学会雑誌　59　(Suppl.)　104-104　2022年5月
出版者・発行元： (一社)日本老年医学会
ISSN：0300-9173
Altruistic Social Activity, Depressive Symptoms, and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis from 8695 Old Adults 国際誌

Yingxu Liu, Ye Zhang, Benjamin Thyreau, Yasuko Tatewaki, Izumi Matsudaira, Yuji Takano, Naoki Hirabayashi, YoshihikTo Furuta, Hata Jun, Toshiharu Ninomiya, Yasuyuki Taki

The Journals of Gerontology: Series A　77　(9)　1789-1797　2022年4月20日

DOI： 10.1093/gerona/glac093 　

ISSN：1079-5006

eISSN：1758-535X
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study 国際誌

Tatsushi Mutoh, Keiko Kunitoki, Yasuko Tatewaki, Shuzo Yamamoto, Benjamin Thyreau, Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki

GeroScience　44　(3)　1325-1338　2022年4月5日

DOI： 10.1007/s11357-022-00553-z 　

ISSN：2509-2715

eISSN：2509-2723
WOMEN AT RISK: SOCIOECONOMIC STATUS, LIFESTYLE FACTORS, AND BRAIN VULNERABILITY AMONG JAPANESE AND SWEDISH FEMALE

benjamin thyreau

INNOVATION IN AGING　2022年
Brain charts for the human lifespan

benjamin thyreau

NATURE　2022年

DOI： 10.1038/S41586-022-04554-Y 　
Brain charts for the human lifespan (vol 604, pg 525, 2022)

benjamin thyreau

NATURE　2022年

DOI： 10.1038/S41586-022-05300-0 　
アルツハイマー病の進行に関与する便秘の影響についての検討

中瀬泰然, 舘脇康子, Thyreau Benjamin, 武藤達士, 冨田尚希, 山本修三, 高野由美, 村中美千帆, 瀧靖之

Dementia Japan　35　(4)　614-614　2021年10月
出版者・発行元： (一社)日本認知症学会
ISSN：1342-646X
認知症病態に関わる心房細動の影響についての検討

中瀬泰然, 竹石潤平, 舘脇康子, Benjamin Thyreau, 武藤達士, 冨田尚希, 山本修三, 高野由美, 村中美千帆, 瀧靖之

Dementia Japan　35　(4)　620-620　2021年10月
出版者・発行元： (一社)日本認知症学会
ISSN：1342-646X
Differential predictors for alcohol use in adolescents as a function of familial risk

benjamin thyreau

TRANSLATIONAL PSYCHIATRY　2021年

DOI： 10.1038/S41398-021-01260-7 　
Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease 国際誌

Yumi Takano, Yasuko Tatewaki, Tatsushi Mutoh, Naoya Morota, Izumi Matsudaira, Benjamin Thyreau, Tatsuo Nagasaka, Hayato Odagiri, Shuzo Yamamoto, Hiroyuki Arai, Yasuyuki Taki

Frontiers in Aging Neuroscience　12　178-178　2020年6月17日

DOI： 10.3389/fnagi.2020.00178 　

eISSN：1663-4365
Learning a cortical parcellation of the brain robust to the MRI segmentation with convolutional neural networks. 国際誌査読有り

Benjamin Thyreau, Yasuyuki Taki

Medical image analysis　61　101639-101639　2020年4月
出版者・発行元： Elsevier {BV}
DOI： 10.1016/j.media.2020.101639 　

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The parcellation of the human cortex into meaningful anatomical units is a common step of various neuroimaging studies. There have been multiple successful efforts to process magnetic resonance (MR) brain images automatically and identify specific anatomical regions, following atlases defined from cortical landmarks. Those definitions usually rely first on a high-quality brain surface reconstruction. On the other hand, when high accuracy is not a requirement, simpler methods based on warping a probabilistic atlas have been widely adopted. Here, we develop a cortical parcellation method for MR brain images based on Convolutional Neural Networks (ConvNets), a machine-learning method, with the goal of automatically transferring the knowledge obtained from surface analyses onto something directly applicable on simpler volume data. We train a ConvNet on a large (thousand) set of cortical ribbons of multiple MRI cohorts, to reproduce parcellations obtained from a surface method, in this case FreeSurfer. Further, to make the model applicable in a broader context, we force the model to generalize to unseen segmentations. The model is evaluated on unseen data of unseen cohorts. We characterize the behavior of the model during learning, and quantify its reliance on the dataset itself, which tends to give support for the necessity of large training sets, augmentation, and multiple contrasts. Overall, ConvNets can provide an efficient way to parcel MRI images, following the guidance established within more complex methods, quickly and accurately. The trained model is embedded within a open-source parcellation tool available at https://github.com/bthyreau/parcelcortex.
Heavy drinking in adolescents is associated with change in brainstem microstructure and reward sensitivity

benjamin thyreau

ADDICTION BIOLOGY　2020年

DOI： 10.1111/ADB.12781 　
ヒト頭蓋のサイズおよび形態のゲノムワイド関連解析

座間味夏帆, 木村亮介, 石田肇, 瀧靖之, 竹内光, Thyreau Benjamin, 今西規

琉球医学会誌　39　(1-4)　95-95　2020年
出版者・発行元：琉球医学会
ISSN：1346-888X
Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images. 国際誌査読有り

Yasuko Tatewaki, Tatsushi Mutoh, Kazuko Omodaka, Benjamin Thyreau, Izumi Matsudaira, Hiroaki Furukawa, Keiji Yamada, Keiko Kunitoki, Ryuta Kawashima, Toru Nakazawa, Yasuyuki Taki

Scientific reports　9　(1)　15148-15148　2019年10月22日

DOI： 10.1038/s41598-019-51611-0 　
Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation

Ernst, M., Benson, B., Artiges, E., Gorka, A.X., Lemaitre, H., Lago, T., Miranda, R., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Br{\"u}hl, R., B{\"u}chel, C., Cattrell, A., Conrod, P., Desrivi{\`e}res, S., Fadai, T., Flor, H., Grigis, A., Gallinat, J., Garavan, H., Gowland, P., Grimmer, Y., Heinz, A., Kappel, V., Nees, F., Papadopoulos-Orfanos, D., Penttil{\"a}, J., Poustka, L., Smolka, M.N., Stringaris, A., Struve, M., van Noort, B.M., Walter, H., Whelan, R., Schumann, G., Grillon, C., Martinot, M.-L.P., Martinot, J.-L., Dalley, J., Subramaniam, N., Theobald, D., Bach, C., Barker, G.J., Fauth-B{\"u}hler, M., Millenet, S., Spanagel, R., Albrecht, L., Ivanov, N., Rapp, M., Reuter, J., Strache, N., Str{\"o}hle, A., Poline, J.B., Schwartz, Y., Thyreau, B., Ireland, J., Rogers, J., Bordas, N., Bricaud, Z., Filippi, I., Galinowski, A., Gollier-Briant, F., Hall, D., Havatzias, S., Jia, T., Mallik, C., Nymberg, C., Ruggeri, B., Smith, L., Stueber, K., Topper, L., Werts, H., Br{\"u}hl, R., Ihlenfeld, A., Walaszek, B., H{\"u}bner, T., M{\"u}ller, K., Paus, T., Ripke, S., Mennigen, E., Schmidt, D., Vetter, N.C., Ziesch, V., Carter, D., Connolly, C., Nugent, S., Jones, J., Yacubian, J., Schneider, S., Head, K., Heym, N., Newman, C., Pausova, Z., Tahmasebi, A., Stephens, D.

Translational Psychiatry　9　(1)　2019年

DOI： 10.1038/s41398-019-0433-6 　
Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

Chaarani, B., Kan, K.-J., Mackey, S., Spechler, P.A., Potter, A., Orr, C., D{'}Alberto, N., Hudson, K.E., Banaschewski, T., Bokde, A.L.W., Bromberg, U., B{\"u}chel, C., Cattrell, A., Conrod, P.J., Desrivi{\`e}res, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Nees, F., Papadopoulos-Orfanos, D., Paus, T., Poustka, L., Smolka, M.N., Walter, H., Whelan, R., Higgins, S.T., Schumann, G., Althoff, R.R., Stein, E.A., Garavan, H., Mann, K., Struve, M., Rietschel, M., Spanagel, R., Fauth-B{\"u}hler, M., Millenet, S., Grimmer, Y., Ivanov, N., Strache, N., Rapp, M., Str{\"o}hle, A., Reuter, J., Barbot, A., Thyreau, B., Schwartz, Y., Lalanne, C., Bricaud, Z., Briand, F.G., Lemaitre, H., Massicotte, J., Vulser, H., Pentill{\"a}, J., Galinowski, A., Jia, T., Werts, H., Topper, L., Reed, L., Andrew, C., Mallik, C., Ruggeri, B., Nymberg, C., Smith, L., Loth, E., Havatzias, S., Stueber, K., Stringaris, A., Constant, P., Br{\"u}hl, R., Ihlenfeld, A., Walaszek, B., H{\"u}bner, T., M{\"u}ller, K., Ripke, S., Rodehacke, S., Mennigen, E., Schmidt, D., Vetter, N., Ziesch, V., Jones, J., Poline, J.-B., Fadai, T., Yacubian, J., Schneider, S., Lawrence, C., Newman, C., Head, K., Heym, N., Pausova, Z., Tahmasebi, A.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging　4　(7)　2019年

DOI： 10.1016/j.bpsc.2019.02.006 　
Comparing fully automated state-of-the-art cerebellum parcellation from magnetic resonance images. 国際誌査読有り

Aaron Carass, Jennifer, L. Cuzzocreo, Shuo Han, Carlos R. Hernandez-Castillo, Paul E. Rasser, Melanie Ganz, Vincent Beliveau, Jose Dolz, Ismail Ben Ayed, Christian Desrosiers, Benjamin Thyreau, José E. Romero, Pierrick Coupé, José, V. Manjón, Vladimir, S. Fonov, D. Louis Collins, Sarah H. Ying, Chiadi U. Onyike, Jerry L. Prince

NeuroImage　183　150-172　2018年12月

DOI： 10.1016/j.neuroimage.2018.08.003 　

ISSN：1053-8119
The initiation of cannabis use in adolescence is predicted by sex-specific psychosocial and neurobiological features

Spechler, P.A., Allgaier, N., Chaarani, B., Whelan, R., Watts, R., Orr, C., Albaugh, M.D., D{'}Alberto, N., Higgins, S.T., Hudson, K.E., Mackey, S., Potter, A., Banaschewski, T., Bokde, A.L.W., Bromberg, U., B{\"u}chel, C., Cattrell, A., Conrod, P.J., Desrivi{\`e}res, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Paill{\`e}re Martinot, M.-L., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Smolka, M.N., Walter, H., Schumann, G., Althoff, R.R., Garavan, H., Mann, K., Struve, M., Rietschel, M., Spanagel, R., Fauth-B{\"u}hler, M., Millenet, S., Grimmer, Y., Ivanov, N., Strache, N., Rapp, M., Str{\"o}hle, A., Reuter, J., Barbot, A., Thyreau, B., Schwartz, Y., Lalanne, C., Bricaud, Z., Briand, F., Lemaitre, H., Massicotte, J., Vulser, H., Pentill{\"a}, J., Galinowski, A., Jia, T., Werts, H., Topper, L., Reed, L., Andrew, C., Mallik, C., Ruggeri, B., Nymberg, C., Smith, L., Loth, E., Havatzias, S., Stueber, K., Stringaris, A., Br{\"u}hl, R., Ihlenfeld, A., Walaszek, B., H{\"u}bner, T., M{\"u}ller, K., Ripke, S., Rodehacke, S., Mennigen, E., Schmidt, D., Vetter, N., Ziesch, V., Poline, J.-B., Fadai, T., Yacubian, J., Lawrence, C., Newman, C., Head, K., Heym, N., Pausova, Z., Tahmasebi, A.

European Journal of Neuroscience　2018年

DOI： 10.1111/ejn.13989 　
Segmentation of the hippocampus by transferring algorithmic knowledge for large cohort processing. 国際誌査読有り

Benjamin Thyreau, Kazunori Sato, Hiroshi Fukuda, Yasuyuki Taki

Medical Image Analysis　43　214-228　2018年1月

DOI： 10.1016/j.media.2017.11.004 　

ISSN：1361-8415
Phase Difference-Enhanced Magnetic Resonance (MR) Imaging (PADRE) Technique for the Detection of Age-Related Microstructural Changes in Optic Radiation: Comparison with Diffusion Tensor Imaging (DTI). 国際誌査読有り

Tatewaki Y, Mutoh T, Thyreau B, Omodaka K, Murata T, Sekiguchi A, Nakazawa T, Taki Y

Medical science monitor : international medical journal of experimental and clinical research　23　5495-5503　2017年11月19日

ISSN：1234-1010

eISSN：1643-3750
Phase Difference-Enhanced Magnetic Resonance (MR) Imaging (PADRE) Technique for the Detection of Age-Related Microstructural Changes in Optic Radiation: Comparison with Diffusion Tensor Imaging (DTI) 査読有り

Yasuko Tatewaki, Tatsushi Mutoh, Benjamin Thyreau, Kazuko Omodaka, Takaki Murata, Atsushi Sekiguchi, Toru Nakazawa, Yasuyuki Taki

MEDICAL SCIENCE MONITOR　23　5495-5503　2017年11月

DOI： 10.12659/MSM.905571 　

ISSN：1643-3750
The neural basis of the imitation drive. 国際誌査読有り

Sugiko Hanawa, Motoaki Sugiura, Takayuki Nozawa, Yuka Kotozaki, Yukihito Yomogida, Mizuki Ihara, Yoritaka Akimoto, Benjamin Thyreau, Shinichi Izumi, Ryuta Kawashima

Social cognitive and affective neuroscience　11　(1)　66-77　2016年1月

DOI： 10.1093/scan/nsv089 　

ISSN：1749-5016

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Spontaneous imitation is assumed to underlie the acquisition of important skills by infants, including language and social interaction. In this study, functional magnetic resonance imaging (fMRI) was used to examine the neural basis of 'spontaneously' driven imitation, which has not yet been fully investigated. Healthy participants were presented with movie clips of meaningless bimanual actions and instructed to observe and imitate them during an fMRI scan. The participants were subsequently shown the movie clips again and asked to evaluate the strength of their 'urge to imitate' (Urge) for each action. We searched for cortical areas where the degree of activation positively correlated with Urge scores; significant positive correlations were observed in the right supplementary motor area (SMA) and bilateral midcingulate cortex (MCC) under the imitation condition. These areas were not explained by explicit reasons for imitation or the kinematic characteristics of the actions. Previous studies performed in monkeys and humans have implicated the SMA and MCC/caudal cingulate zone in voluntary actions. This study also confirmed the functional connectivity between Urge and imitation performance using a psychophysiological interaction analysis. Thus, our findings reveal the critical neural components that underlie spontaneous imitation and provide possible reasons why infants imitate spontaneously.
Regional Reliability of Quantitative Signal Targeting with Alternating Radiofrequency (STAR) Labeling of Arterial Regions (QUASAR) 国際誌査読有り

Yasuko Tatewaki, Shuichi Higano, Yasuyuki Taki, Benjamin Thyreau, Takaki Murata, Shunji Mugikura, Daisuke Ito, Kei Takase, Shoki Takahashi

JOURNAL OF NEUROIMAGING　24　(6)　554-561　2014年11月

DOI： 10.1111/jon.12076 　

ISSN：1051-2284

eISSN：1552-6569
Oxytocin receptor genotype modulates ventral striatal activity to social cues and response to stressful life events. 国際誌査読有り

Loth E, Poline JB, Thyreau B, Jia T, Tao C, Lourdusamy A, Stacey D, Cattrell A, Desrivières S, Ruggeri B, Fritsch V, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Carvalho FM, Conrod PJ, Fauth-Buehler M, Flor H, Gallinat J, Garavan H, Heinz A, Bruehl R, Lawrence C, Mann K, Martinot JL, Nees F, Paus T, Pausova Z, Poustka L, Rietschel M, Smolka M, Struve M, Feng J, Schumann G, IMAGEN Consortium

Biological psychiatry　76　(5)　367-76　2014年9月1日

DOI： 10.1016/j.biopsych.2013.07.043 　

ISSN：0006-3223
Healthy children show gender differences in correlations between nonverbal cognitive ability and brain activation during visual perception. 国際誌査読有り

Asano K, Taki Y, Hashizume H, Sassa Y, Thyreau B, Asano M, Takeuchi H, Kawashima R

Neuroscience letters　577　66-71　2014年8月8日

DOI： 10.1016/j.neulet.2014.06.015 　

ISSN：0304-3940
Developmental changes in brain activation involved in the production of novel speech sounds in children. 国際誌査読有り

Hiroshi Hashizume, Yasuyuki Taki, Yuko Sassa, Benjamin Thyreau, Michiko Asano, Kohei Asano, Hikaru Takeuchi, Rui Nouchi, Yuka Kotozaki, Hyeonjeong Jeong, Motoaki Sugiura, Ryuta Kawashima

Human brain mapping　35　(8)　4079-89　2014年8月

DOI： 10.1002/hbm.22460 　

ISSN：1065-9471

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Older children are more successful at producing unfamiliar, non-native speech sounds than younger children during the initial stages of learning. To reveal the neuronal underpinning of the age-related increase in the accuracy of non-native speech production, we examined the developmental changes in activation involved in the production of novel speech sounds using functional magnetic resonance imaging. Healthy right-handed children (aged 6-18 years) were scanned while performing an overt repetition task and a perceptual task involving aurally presented non-native and native syllables. Productions of non-native speech sounds were recorded and evaluated by native speakers. The mouth regions in the bilateral primary sensorimotor areas were activated more significantly during the repetition task relative to the perceptual task. The hemodynamic response in the left inferior frontal gyrus pars opercularis (IFG pOp) specific to non-native speech sound production (defined by prior hypothesis) increased with age. Additionally, the accuracy of non-native speech sound production increased with age. These results provide the first evidence of developmental changes in the neural processes underlying the production of novel speech sounds. Our data further suggest that the recruitment of the left IFG pOp during the production of novel speech sounds was possibly enhanced due to the maturation of the neuronal circuits needed for speech motor planning. This, in turn, would lead to improvement in the ability to immediately imitate non-native speech.
Spinal fMRI of interoceptive attention/awareness in experts and novices. 国際誌査読有り

Keyvan Kashkouli Nejad, Motoaki Sugiura, Benjamin Thyreau, Takayuki Nozawa, Yuka Kotozaki, Yoshihito Furusawa, Kozo Nishino, Toshohiro Nukiwa, Ryuta Kawashima

Neural plasticity　2014　679509-679509　2014年

DOI： 10.1155/2014/679509 　

ISSN：2090-5904

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Many disciplines/traditions that promote interoceptive (inner sensation of body parts) attention/awareness (IAA) train practitioners to both attend to and be aware of interoceptive sensory experiences in body parts. The effect of such practices has been investigated in previous imaging studies but limited to cerebral neural activity. Here, for the first time, we studied the impact of these practices on the spinal neural activity of experts and novices. We also attempted to clarify the effect of constant and deep breathing, a paradigm utilized in concentration practices to avoid mind wandering, on IAA-related spinal neural activity. Subjects performed IAA tasks with and without a deep and constant breathing pattern in two sessions. Results showed that neural activity in the spinal segment innervating the attended-to body area increased in experts (P = 0.04) when they performed IAA and that this increase was significantly larger for experts versus novices in each of the sessions (P = 0.024). The significant effects of IAA and expertise on spinal neural activity are consistent with and elaborate on previous reports showing similar effects on cerebral neural activity. As the spinal cord directly innervates body parts, the results might indicate that IAA has an instantaneous (possibly beneficial) effect on the physical body after extended training.
Correlations between brain structures and study time at home in healthy children: a longitudinal analysis. 国際誌査読有り

Asano M, Taki Y, Hashizume H, Takeuchi H, Thyreau B, Sassa Y, Asano K, Kawashima R

Brain and behavior　4　(6)　801-11　2014年

DOI： 10.1002/brb3.278 　
A longitudinal study of the relationship between personality traits and the annual rate of volume changes in regional gray matter in healthy adults. 国際誌査読有り

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

Human brain mapping　34　(12)　3347-53　2013年12月

DOI： 10.1002/hbm.22145 　

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To investigate whether personality traits affect the rate of decline of gray matter volume, we analyzed the relationships between personality traits and the annual rate of changes of gray matter volume in 274 healthy community dwelling subjects with a large age range by applying a longitudinal design over 6 years, using brain magnetic resonance images (MRI) and the Revised NEO Personality Inventory (NEO-PI-R) at baseline. Brain MRI data were processed using voxel-based morphometry with a custom template by applying the DARTEL diffeomorphic registration tool. For each subject, we used NEO-PI-R to evaluate the five major personality traits, including neuroticism, extraversion, openness, agreeableness, and conscientiousness. The results show that the annual rate of change in regional gray matter volume in the right inferior parietal lobule was correlated significantly and negatively with a personality of openness, which is known to be related to intellect, intellectual curiosity, and creativity adjusting for age, gender, and intracranial volume. This result indicates that subjects with a personality trait of less openness have an accelerated loss of gray matter volume in the right inferior parietal lobule, compared with subjects with a personality trait of more openness. Because the right inferior parietal lobule is involved in higher cognitive function such as working memory and creativity, a personality trait of openness is thought to be important for preserving gray matter volume and cognitive function of the right inferior parietal lobule in healthy adults.
Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects. 国際誌査読有り

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Masako Kakizaki, Ichiro Tsuji, Ryuta Kawashima, Hiroshi Fukuda

Human brain mapping　34　(10)　2418-24　2013年10月

DOI： 10.1002/hbm.22073 　

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Although elevated serum high-sensitivity C-reactive protein (hsCRP) is related to atherosclerosis, brain infarction, and cognitive decline, it has not been clarified whether increased hsCRP is associated with the decline in brain gray matter volume. Therefore, the purpose of this study was to determine the relationship between hsCRP levels and brain regional gray matter volume using brain magnetic resonance imaging (MRI) data from 109 community-dwelling healthy elderly subjects. Brain MRIs were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra (DARTEL) procedure. We found a significant negative correlation between regional gray matter volume of the posterior and lateral aspects of the left temporal cortex and hsCRP level after adjusting for age, gender, and intracranial volume. Our results suggest that subjects who have mild inflammation related to arteriosclerosis have decreased regional gray matter volume in the posterior and lateral aspects of the left temporal cortex. Thus, preventing the progression of arteriosclerosis may be important for preventing a decrease in gray matter volume in healthy elderly subjects.
A longitudinal study of age- and gender-related annual rate of volume changes in regional gray matter in healthy adults. 国際誌査読有り

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

Human brain mapping　34　(9)　2292-301　2013年9月

DOI： 10.1002/hbm.22067 　

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The aim of this study was to analyze correlations among the annual rate of gray matter volume change, age, gender, and cerebrovascular risk factors in 381 healthy community-dwelling subjects with a large age range by applying a longitudinal design over 6 years using brain magnetic resonance images (MRIs). Brain MRI data were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. The annual rate of regional gray matter volume change showed significant positive correlations with age in several regions, including the bilateral temporal pole, caudate nucleus, ventral and dorsolateral prefrontal cortices, insula, hippocampus, and temporoparietal cortex, whereas significant negative correlations with age were observed in several regions including the bilateral cingulate gyri and anterior lobe of the cerebellum. Additionally, a significant age-by-gender interaction was found for the annual rate of regional gray matter volume change in the bilateral hippocampus. No significant correlations were observed between the annual rate of regional gray matter volume change and body mass index or systolic blood pressure. A significant positive correlation between the annual rate of gray matter volume change and age indicates that the region shows not linear but accelerated gray matter loss with age. Therefore, evaluating the annual rate of the gray matter volume change with age in healthy subjects is important in understanding how gray matter volume changes with aging in each brain region and in anticipating what cognitive functions are likely to show accelerated decline with aging.
White matter structures associated with empathizing and systemizing in young adults. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Benjamin Thyreau, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Tomomi Nagase, Rui Nouchi, Ai Fukushima, Ryuta Kawashima

NeuroImage　77　222-36　2013年8月15日

DOI： 10.1016/j.neuroimage.2013.04.004 　
Linear and curvilinear correlations of brain white matter volume, fractional anisotropy, and mean diffusivity with age using voxel-based and region-of-interest analyses in 246 healthy children. 国際誌査読有り

Yasuyuki Taki, Benjamin Thyreau, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

Human brain mapping　34　(8)　1842-56　2013年8月

DOI： 10.1002/hbm.22027 　

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In this study, we examined linear and curvilinear correlations of fractional anisotropy (FA), mean diffusivity (MD), and white matter volume with age by using brain structural and diffusion-tensor magnetic resonance imaging (MRI) in a large number of healthy children and voxel-based morphometry (VBM) and region-of-interest (ROI) analyses. We collected data by brain structural MRI in 246 healthy children, aged 5-18 years. FA and MD images were normalized using the normalization parameter of the corresponding structural MRI. Next, we analyzed the correlations between FA and age and between MD and age by estimating linear and logarithmic functions. We also analyzed the correlation between white matter volume and age by linear, quadratic, and cubic functions. Correlations between FA and age and between MD and age showed exponential trajectories in most ROIs in boys and girls, except for several fibers, such as the corpus callosum connecting the bilateral rectal gyri in boys. The correlation between white matter volume and age showed significant positive linear trajectories in most ROIs in boys and girls, except for a few fibers, such as the bilateral uncinate fasciculus. Additionally, maturational rates differed among major fibers, and in girls, the left superior longitudinal fasciculus, which connects the frontal and temporal lobes, showed a slower rate of maturation than other fibers. Our results may help to clarify the mechanisms of normal brain maturation from the viewpoint of brain white matter.
Linear and curvilinear correlations of brain gray matter volume and density with age using voxel-based morphometry with the Akaike information criterion in 291 healthy children. 国際誌査読有り

Yasuyuki Taki, Hiroshi Hashizume, Benjamin Thyreau, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

Human brain mapping　34　(8)　1857-71　2013年8月

DOI： 10.1002/hbm.22033 　

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We examined linear and curvilinear correlations of gray matter volume and density in cortical and subcortical gray matter with age using magnetic resonance images (MRI) in a large number of healthy children. We applied voxel-based morphometry (VBM) and region-of-interest (ROI) analyses with the Akaike information criterion (AIC), which was used to determine the best-fit model by selecting which predictor terms should be included. We collected data on brain structural MRI in 291 healthy children aged 5-18 years. Structural MRI data were segmented and normalized using a custom template by applying the diffeomorphic anatomical registration using exponentiated lie algebra (DARTEL) procedure. Next, we analyzed the correlations of gray matter volume and density with age in VBM with AIC by estimating linear, quadratic, and cubic polynomial functions. Several regions such as the prefrontal cortex, the precentral gyrus, and cerebellum showed significant linear or curvilinear correlations between gray matter volume and age on an increasing trajectory, and between gray matter density and age on a decreasing trajectory in VBM and ROI analyses with AIC. Because the trajectory of gray matter volume and density with age suggests the progress of brain maturation, our results may contribute to clarifying brain maturation in healthy children from the viewpoint of brain structure.
Correlation between pulmonary function and brain volume in healthy elderly subjects. 国際誌査読有り

Yasuyuki Taki, Shigeo Kinomura, Satoru Ebihara, Benjamin Thyreau, Kazunori Sato, Ryoi Goto, Masako Kakizaki, Ichiro Tsuji, Ryuta Kawashima, Hiroshi Fukuda

Neuroradiology　55　(6)　689-95　2013年6月

DOI： 10.1007/s00234-013-1157-6 　

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INTRODUCTION: Cigarette smoking decreases brain regional gray matter volume and is related to chronic obstructive lung disease (COPD). COPD leads to decreased pulmonary function, which is represented by forced expiratory volume in one second percentage (FEV1.0 %); however, it is unclear if decreased pulmonary function is directly related to brain gray matter volume decline. Because there is a link between COPD and cognitive decline, revealing a direct relationship between pulmonary function and brain structure is important to better understand how pulmonary function affects brain structure and cognitive function. Therefore, the purpose of this study was to analyze whether there were significant correlations between FEV1.0 % and brain regional gray and white matter volumes using brain magnetic resonance (MR) image data from 109 community-dwelling healthy elderly individuals. METHODS: Brain MR images were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. RESULTS: We found a significant positive correlation between the regional white matter volume of the cerebellum and FEV1.0 % after adjusting for age, sex, and intracranial volume. CONCLUSION: Our results suggest that elderly individuals who have a lower FEV1.0 % have decreased regional white matter volume in the cerebellum. Therefore, preventing decreased pulmonary function is important for cerebellar white matter volume in the healthy elderly population.
Schizophrenia as a network disease: disruption of emergent brain function in patients with auditory hallucinations. 国際誌査読有り

Irina Rish, Guillermo Cecchi, Benjamin Thyreau, Bertrand Thirion, Marion Plaze, Marie Laure Paillere-Martinot, Catherine Martelli, Jean-Luc Martinot, Jean-Baptiste Poline

PloS one　8　(1)　e50625　2013年

DOI： 10.1371/journal.pone.0050625 　

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Schizophrenia is a psychiatric disorder that has eluded characterization in terms of local abnormalities of brain activity, and is hypothesized to affect the collective, "emergent" working of the brain. Indeed, several recent publications have demonstrated that functional networks in the schizophrenic brain display disrupted topological properties. However, is it possible to explain such abnormalities just by alteration of local activation patterns? This work suggests a negative answer to this question, demonstrating that significant disruption of the topological and spatial structure of functional MRI networks in schizophrenia (a) cannot be explained by a disruption to area-based task-dependent responses, i.e. indeed relates to the emergent properties, (b) is global in nature, affecting most dramatically long-distance correlations, and (c) can be leveraged to achieve high classification accuracy (93%) when discriminating between schizophrenic vs control subjects based just on a single fMRI experiment using a simple auditory task. While the prior work on schizophrenia networks has been primarily focused on discovering statistically significant differences in network properties, this work extends the prior art by exploring the generalization (prediction) ability of network models for schizophrenia, which is not necessarily captured by such significance tests.
Topological organization of functional brain networks in healthy children: differences in relation to age, sex, and intelligence. 国際誌査読有り

Kai Wu, Yasuyuki Taki, Kazunori Sato, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Benjamin Thyreau, Yong He, Alan C Evans, Xiaobo Li, Ryuta Kawashima, Hiroshi Fukuda

PloS one　8　(2)　e55347　2013年

DOI： 10.1371/journal.pone.0055347 　

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Recent studies have demonstrated developmental changes of functional brain networks derived from functional connectivity using graph theoretical analysis, which has been rapidly translated to studies of brain network organization. However, little is known about sex- and IQ-related differences in the topological organization of functional brain networks during development. In this study, resting-state fMRI (rs-fMRI) was used to map the functional brain networks in 51 healthy children. We then investigated the effects of age, sex, and IQ on economic small-world properties and regional nodal properties of the functional brain networks. At a global level of whole networks, we found significant age-related increases in the small-worldness and local efficiency, significant higher values of the global efficiency in boys compared with girls, and no significant IQ-related difference. Age-related increases in the regional nodal properties were found predominately in the frontal brain regions, whereas the parietal, temporal, and occipital brain regions showed age-related decreases. Significant sex-related differences in the regional nodal properties were found in various brain regions, primarily related to the default mode, language, and vision systems. Positive correlations between IQ and the regional nodal properties were found in several brain regions related to the attention system, whereas negative correlations were found in various brain regions primarily involved in the default mode, emotion, and language systems. Together, our findings of the network topology of the functional brain networks in healthy children and its relationship with age, sex, and IQ bring new insights into the understanding of brain maturation and cognitive development during childhood and adolescence.
Neural correlates of deception in social contexts in normally developing children. 国際誌査読有り

Susumu Yokota, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Benjamin Thyreau, Mari Tanaka, Ryuta Kawashima

Frontiers in human neuroscience　7　206-206　2013年

DOI： 10.3389/fnhum.2013.00206 　

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Deception is related to the ability to inhibit prepotent responses and to engage in mental tasks such as anticipating responses and inferring what another person knows, especially in social contexts. However, the neural correlates of deception processing, which requires mentalizing, remain unclear. Using functional magnetic resonance imaging (fMRI), we examined the neural correlates of deception, including mentalization, in social contexts in normally developing children. Healthy right-handed children (aged 8-9 years) were scanned while performing interactive games involving deception. The games varied along two dimensions: the type of reply (deception and truth) and the type of context (social and less social). Participants were instructed to deceive a witch and to tell the truth to a girl. Under the social-context conditions, participants were asked to consider what they inferred about protagonists' preferences from their facial expressions when responding to questions. Under the less-social-context conditions, participants did not need to consider others' preferences. We found a significantly greater response in the right precuneus under the social-context than under less-social-context conditions. Additionally, we found marginally greater activation in the right inferior parietal lobule (IPL) under the deception than under the truth condition. These results suggest that deception in a social context requires not only inhibition of prepotent responses but also engagement in mentalizing processes. This study provides the first evidence of the neural correlates of the mentalizing processes involved in deception in normally developing children.
Detecting outliers in high-dimensional neuroimaging datasets with robust covariance estimators. 国際誌査読有り

Virgile Fritsch,Array,Benjamin Thyreau,Jean-Baptiste Poline,Bertrand Thirion

Medical Image Analysis　16　(7)　1359-70　2012年10月

DOI： 10.1016/j.media.2012.05.002 　
Adolescent impulsivity phenotypes characterized by distinct brain networks. 国際誌査読有り

Robert Whelan, Patricia J Conrod, Jean-Baptiste Poline, Anbarasu Lourdusamy, Tobias Banaschewski, Gareth J Barker, Mark A Bellgrove, Christian Büchel, Mark Byrne, Tarrant D R Cummins, Mira Fauth-Bühler, Herta Flor, Jürgen Gallinat, Andreas Heinz, Bernd Ittermann, Karl Mann, Jean-Luc Martinot, Edmund C Lalor, Mark Lathrop, Eva Loth, Frauke Nees, Tomas Paus, Marcella Rietschel, Michael N Smolka, Rainer Spanagel, David N Stephens, Maren Struve, Benjamin Thyreau, Sabine Vollstaedt-Klein, Trevor W Robbins, Gunter Schumann, Hugh Garavan

Nature neuroscience　15　(6)　920-5　2012年6月

DOI： 10.1038/nn.3092 　

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The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large sample (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.
Very large fMRI study using the IMAGEN database: Sensitivity-specificity and population effect modeling in relation to the underlying anatomy. 国際誌査読有り

Benjamin Thyreau, Yannick Schwartz,Bertrand Thirion,Vincent Frouin,Array,Array,Tomás Paus,Array, Patricia J. Conrod, Gunter Schumann,Array,Jean-Baptiste Poline

NeuroImage　61　(1)　295-303　2012年5月15日

DOI： 10.1016/j.neuroimage.2012.02.083 　
Sleep duration during weekdays affects hippocampal gray matter volume in healthy children. 国際誌査読有り

Yasuyuki Taki, Hiroshi Hashizume, Benjamin Thyreau, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

NeuroImage　60　(1)　471-5　2012年3月

DOI： 10.1016/j.neuroimage.2011.11.072 　

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Sleep is essential for living beings, and sleep loss has been shown to affect hippocampal structure and function in rats by inhibiting cell proliferation and neurogenesis in this region of the brain. We aimed to analyze the correlation between sleep duration and the hippocampal volume using brain magnetic resonance images of 290 healthy children aged 5-18 years. We examined the volume of gray matter, white matter, and the cerebrospinal fluid (CSF) space in the brain using a fully automated and established neuroimaging technique, voxel-based morphometry, which enabled global analysis of brain structure without bias towards any specific brain region while permitting the identification of potential differences or abnormalities in brain structures. We found that the regional gray matter volume of the bilateral hippocampal body was significantly positively correlated with sleep duration during weekdays after adjusting for age, sex, and intracranial volume. Our results indicated that sleep duration affects the hippocampal regional gray matter volume of healthy children. These findings advance our understanding of the importance of sleep habits in the daily lives of healthy children.
PyXNAT: XNAT in Python 国際誌査読有り

Yannick Schwartz, Alexis Barbot, Benjamin Thyreau,Vincent Frouin, Gaël Varoquaux, Aditya Siram, Daniel S. Marcus, Jean-Baptiste Poline

CoRR　6　12-12　2012年

DOI： 10.3389/fninf.2012.00012 　
Apathy is related to cortex morphology in CADASIL A sulcal-based morphometry study 査読有り

E. Jouvent, S. Reyes, J. -F. Mangin, P. Roca, M. Perrot, B. Thyreau, D. Herve, M. Dichgans, H. Chabriat

NEUROLOGY　76　(17)　1472-1477　2011年4月

ISSN：0028-3878
Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals. 国際誌査読有り

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Ryuta Kawashima, Hiroshi Fukuda

PloS one　6　(7)　e22734　2011年

DOI： 10.1371/journal.pone.0022734 　

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To determine the relationship between age and gray matter structure and how interactions between gender and hemisphere impact this relationship, we examined correlations between global or regional gray matter volume and age, including interactions of gender and hemisphere, using a general linear model with voxel-based and region-of-interest analyses. Brain magnetic resonance images were collected from 1460 healthy individuals aged 20-69 years; the images were linearly normalized and segmented and restored to native space for analysis of global gray matter volume. Linearly normalized images were then non-linearly normalized and smoothed for analysis of regional gray matter volume. Analysis of global gray matter volume revealed a significant negative correlation between gray matter ratio (gray matter volume divided by intracranial volume) and age in both genders, and a significant interaction effect of age × gender on the gray matter ratio. In analyzing regional gray matter volume, the gray matter volume of all regions showed significant main effects of age, and most regions, with the exception of several including the inferior parietal lobule, showed a significant age × gender interaction. Additionally, the inferior temporal gyrus showed a significant age × gender × hemisphere interaction. No regional volumes showed significant age × hemisphere interactions. Our study may contribute to clarifying the mechanism(s) of normal brain aging in each brain region.
Detecting outlying subjects in high-dimensional neuroimaging datasets with regularized minimum covariance determinant. 国際誌査読有り

Virgile Fritsch, Gael Varoquaux, Benjamin Thyreau, Jean-Baptiste Poline, Bertrand Thirion

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention　14　(Pt 3)　264-71　2011年

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Medical imaging datasets used in clinical studies or basic research often comprise highly variable multi-subject data. Statistically-controlled inclusion of a subject in a group study, i.e. deciding whether its images should be considered as samples from a given population or whether they should be rejected as outlier data, is a challenging issue. While the informal approaches often used do not provide any statistical assessment that a given dataset is indeed an outlier, traditional statistical procedures are not well-suited to the noisy, high-dimensional, settings encountered in medical imaging, e.g. with functional brain images. In this work, we modify the classical Minimum Covariance Determinant approach by adding a regularization term, that ensures that the estimation is well-posed in high-dimensional settings and in the presence of many outliers. We show on simulated and real data that outliers can be detected satisfactorily, even in situations where the number of dimensions of the data exceeds the number of observations.
Voxelwise Multivariate Statistics and Brain-Wide Machine Learning Using the Full Diffusion Tensor. 国際誌査読有り

Anne-Laure Fouque, Pierre Fillard,Anne Bargiacchi,Array,Monica Zilbovicius, Benjamin Thyreau, Edith Le Floch, Philippe Ciuciu, Edouard Duchesnay

Medical Image Computing and Computer-Assisted Intervention - MICCAI 2011 - 14th International Conference, Toronto, Canada, September 18-22, 2011, Proceedings, Part II　14　(Pt 2)　9-16　2011年
出版者・発行元： Springer
Breakfast Staple Types Affect Brain Gray Matter Volume and Cognitive Function in Healthy Children 査読有り

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Kohei Asano, Ryuta Kawashima

PLOS ONE　5　(12)　e15213　2010年12月

DOI： 10.1371/journal.pone.0015213 　

ISSN：1932-6203
Discriminative Network Models of Schizophrenia. 査読有り

Guillermo A. Cecchi, Irina Rish, Benjamin Thyreau,Bertrand Thirion,Marion Plaze, Marie-Laure Paillère-Martinot,Catherine Martelli, Jean-Luc Martinot, Jean-Baptiste Poline

Advances in Neural Information Processing Systems 22: 23rd Annual Conference on Neural Information Processing Systems 2009. Proceedings of a meeting held 7-10 December 2009, Vancouver, British Columbia, Canada.　252-260　2009年
出版者・発行元： Curran Associates, Inc.
Anatomo-functional description of the brain: A probabilistic approach 査読有り

Benjamin Thyreau, Bertrand Thirion, Guillaume Flandin, Jean-Baptiste Poline

2006 IEEE International Conference on Acoustics, Speech and Signal Processing, Vols 1-13　5967-5970　2006年

ISSN：1520-6149
Anatomo-functional description of the brain: A probabilistic approach 査読有り

Benjamin Thyreau, Bertrand Thirion, Guillaume Flandin, Jean-Baptiste Poline

2006 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING, VOL V, PROCEEDINGS　1109-+　2006年

DOI： 10.1109/ICASSP.2006.1661474 　

ISSN：1520-6149

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MISC 7

MRIを用いた緑内障患者の眼球形態の検討

國時景子, 國時景子, 舘脇康子, 面高宗子, 松平泉, THYREAU Benjamin, 武藤達士, 川島隆太, 中澤徹, 瀧靖之, 瀧靖之

日本疫学会学術総会講演集(Web)　29th　2019年
PRE-EXISTING SMALLER DLPFC VOLUME CONTRIBUTES TO POST-TRAUMATIC GROWTH AFTER A DISASTER IN CHILDREN

Atsushi Sekiguchi, Yuka Kotozaki, Thyreau Benjamin, Hikaru Takeuchi, Susumu Yokota, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

PSYCHOSOMATIC MEDICINE　79　(4)　A60-A61　2017年5月

ISSN： 0033-3174

eISSN： 1534-7796
高齢者におけるイソフラボン摂取が脳容量・認知機能に及ぼす影響

辻一郎, 遠又靖丈, THYREAU Benjamin, 瀧靖之, 瀧靖之, 渡邉崇, 杉山賢明, 小暮真奈, CHOU Wan‐Ting, 本蔵賢治, 海法悠, 松尾兼幸, 菅原由美, 曽根稔雅, 曽根稔雅, 高橋英子, 柿崎真沙子, 相田潤

大豆たん白質研究　17　(35)　90-94　2015年6月
出版者・発行元：不二たん白質研究振興財団
ISSN： 1344-4050
An fMRI study on implicit and explicit second language knowledge modulated by task types and proficiency level

Jeong H, Ellis R, Suzuki W, Kashkouli Nejad K, Thyreau B, Magistro D, Yokoyama S, Kawashima R

Proceedings of The 17th Annual International Conference of the Japanese Society for Language SciencesProceedings of The 17th Annual International Conference of the Japanese Society for Language Sciences　162-163　2015年6月
Learning foreign language vocabularies from communicative context: an fMRI study 査読有り

Jeong H, Sugiura M, Yokoyama S, Hashizume H, Takahashi K, Thyreau B, Suzuki W, Kawashima R

Proceedings of The 15th Annual International Conference of the Japanese Society for Language Sciences　30-34　2013年7月
小児における外国語音産出能力と脳形態の相関について

HASHIZUME Hiroshi, TAKI Yasuyuki, THYREAU Benjamin, SASSA Yuko, ASANO Michiko, ASANO Kohei, TAKEUCHI Hikaru, JEONG Hyeonjeong, SUGIURA Motoaki, KAWASHIMA Ryuta

日本神経化学会大会抄録集(Web)　56th　2013年
小児における外国語発音能力と外国語音産出に関わる脳活動の発達的変化の関係

橋爪寛, 瀧靖之, 佐々祐子, ティローバンジャマン, 浅野路子, 浅里孝平, 竹内光, 野内類, 事崎由佳, ジョンヒョンジョン, 杉浦元亮, 川島隆太

電子情報通信学会技術研究報告. TL, 思考と言語　112　(145)　19-23　2012年7月14日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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小児は、外国語音声を獲得するのに適している時期だと考えられているため、小児の外国語音声処理を明らかにすることは、外国語教育において有用である。我々は、6〜18歳の右利き健常日本人小児を対象に、機能的MRIを用いて、母国語にはない外国語の音声(1音節)を聞いて繰り返して発話する際の脳活動の発達的変化を調べた。本研究の結果から、成人対象の先行研究で、外国語音声を繰り返す際、言語音産出のための運動計画に関与するとされている左側下前頭回弁蓋部の活動が、年齢とともに増加することが分かった。外国語音声の発話精度も年齢とともに向上していたことから、左下前頭回弁蓋部の脳領域の発達が、外国語音声の即座の繰り返しの精度向上に反映している可能性がある。

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共同研究・競争的資金等の研究課題 2

脳MRI定量指標の臨床応用へ：AIを用いた画像駆動型緑内障診断ソフトウェアの開発

舘脇康子, 瀧靖之, 中澤徹, Thyreau Benjamin, 武藤達士, 面高宗子

2021年4月1日～ 2024年3月31日

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緑内障は本邦において推計400万人が罹患する老年病であり、網膜神経節細胞脱落部位に応じた進行性の視野障害を特徴とする。緑内障では網膜だけではなく中枢視路である視神経から大脳視覚野にまで体系的に変性が及び、MRI技術を用いてこれらの変化を詳細に可視化・定量化する試みが行われているが、未だ臨床応用には至っていない。本研究は脳MRI画像から得られる視野障害の程度を反映する定量指標を、客観的な新たな視機能評価法として臨床応用することを目指す。本研究は既存の知見をもとに脳MRI情報から視機能を予測するモデル構築を行い、さらにAIを活用して高精度の診断性能を持つソフトウェア開発を目指したものである。当初、R3年度は100名のテストデータの収集を予定していたが、コロナ感染の収束が見通せず、データ収集は断念した。代わりに、当該年度では既存の緑内障縦断MRIデータベースの約280症例のデータを用いて、画像解析プログラム開発を進めた。まずは、眼科データの充実化を行った。これまでのデータベースに含まれていたMDやOCTによるRNFLTの値だけではなく、網膜に残存する網膜神経節細胞数の推定値であるwRGC（weighted retinal ganglion cell count）の算出を行い、緑内障進行度を示すパラメータとして追加した。wRGCは緑内障の早期から後期にかけての視機能との追従性が良好で、既存のパラメータと比較して緑内障の進行度をより正確にとらえることができると考えられる。次に、画像解析に先立ち、緑内障縦断コホートの解剖学的3D-T1強調画像を対象としてFreesurferにより詳細な灰白質構造の抽出を行い、percellationとsegmentation技術を用いて全脳の解剖学的構造を関心領域とした、各構造の体積と皮質厚データを取得し、視野を推定する数理モデル作成およびAIシステム構築のための準備を行った。
明示的・暗示的言語知識テスト開発と個人差－脳科学的アプローチによる検討－

Jeong Hyeonjeong, Thyreau Benjamin, 鈴木祐一

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2015年4月1日～ 2019年3月31日

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本研究の目的は、脳機能イメージングの手法を用いて、第二言語学習者の暗示的知識と明示的知識の処理に関与する脳メカニズムを解明することである。そのため、日本人英語学習者と中国人日本語学習者を対象に、暗示的知識と明示的知識を測定する二つのfMRI実験を行なった。その結果、日本で英語を学習している英語学習者のほとんどは明示的知識に関与する脳領域を用いて英語の文法を処理しているが、日本で日本語を学習している中国語母語話者は、暗示的知識に関与している脳領域を用いて日本語の文法処理を行っていることがわかった。これらの結果から、学習環境が暗示的・明示的知識の質と量を決める重要な要因であることが示唆された。