東北大学研究者紹介

研究者詳細

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カワシマ　リユウタ

川島　隆太

Ryuta Kawashima

所属

加齢医学研究所　脳科学研究部門　応用脳科学研究分野

職名

教授

学位

医学博士（東北大学）

researchmap

https://researchmap.jp/ryuta.kawashima

J-GLOBAL ID

200901068837984183

経歴 4

2001年5月～継続中

東北大学　教授
1998年6月～ 2001年4月

東北大学　講師
1993年7月～ 1998年5月

東北大学　助手
1991年7月～ 1993年4月

カロリンスカ研究所

学歴 2

東北大学　医学研究科

～ 1989年3月
東北大学　医学部

～ 1985年3月

研究キーワード 6

脳機能イメージング
脳機能マッピング
２光子顕微鏡
多チャンネルEEG
NIRS
functional MRI

研究分野 1

ライフサイエンス / 神経科学一般 /

受賞 13

河北文化賞

2013年1月17日　河北文化事業団
井上春成賞

2009年7月15日　井上春成賞委員会
平成21年度科学技術分野の文部科学大臣表彰科学技術賞

2009年4月14日　文部科学省
平成20年度「情報通信月間」総務大臣表彰

2008年6月1日　総務省
日本ＰＲ（パーソン・オブザイヤー）大賞

2007年1月　日本ＰＲ協会
科学技術への顕著な貢献in2006

2006年12月　文部科学省科学技術政策研究所
トレンド大賞

2006年12月　（株）小学館
流行語大賞

2006年12月　（株）ユーキャン
Hiramek-ist Award 2006

2006年11月　（株）リプトン
日本ゲーム大賞

2006年10月　一般社団法人コンピュータエンターテインメント協会
Top 50 Innovators in New Media for 2006

2006年9月　Producers Guild of America New Media Coucil
日本神経回路学会論文賞

2004年9月　日本神経回路学会
第34回日本核医学会賞

1996年10月　日本核医学会

︎全件表示 ︎最初の5件までを表示

論文 603

The neural basis of coping strategies for boredom and their association with creativity

Sugiko Hanawa, Takayuki Nozawa, Motoaki Sugiura, Rui Nouchi, Ryoichi Yokoyama, Benjamin Thyreau, Yuka Kotozaki, Tsuyoshi Araki, Ryuta Kawashima

Thinking Skills and Creativity　101794-101794　2025年2月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.tsc.2025.101794 　

ISSN：1871-1871
Rising-frequency chirp stimuli effectively enhance the amplitude and shorten the latency of 40-hz auditory steady-state response

Shunsuke Takai, Takashi Morimoto, Akitake Kanno, Tetsuaki Kawase, Jun Suzuki, Nobukatsu Nakasato, Ryuta Kawashima, Yukio Katori

International Journal of Audiology　1-8　2024年12月10日
出版者・発行元： Informa UK Limited
DOI： 10.1080/14992027.2024.2430765 　

ISSN：1499-2027

eISSN：1708-8186
Self-Choice Emotion Regulation Enhances Stress Reduction: Neural Basis of Self-Choice Emotion Regulation

Nozomi Imajo, Yutaka Matsuzaki, Akiko Kobayashi, Kohei Sakaki, Rui Nouchi, Ryuta Kawashima

Brain Sciences　14　(11)　1077-1077　2024年10月28日
出版者・発行元： MDPI AG
DOI： 10.3390/brainsci14111077 　

eISSN：2076-3425

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Background/Objectives: Opting to perform emotion regulation when facing high-arousal stimuli enhances the reduction in negative emotions. Previous research has indicated that self-choice, that is, personally choosing from multiple alternatives, can improve performance. However, it is unclear whether the emotion regulation strategy chosen among multiple alternatives in daily life enhances stress reduction compared to a forced strategy. This study aimed to reveal the effects of self-choice emotion regulation and its underlying neural basis. Methods: Participants were 40 healthy adults who met the inclusion criteria; they performed self-choice emotion regulation, forced emotion regulation, and no emotion regulation (the control condition) while their brain activity was captured using a functional magnetic resonance imaging scanner. First, the participants were shown a stressful scenario. Secondly, they rated the stress they experienced. Thirdly, they performed self-choice or forced emotion regulation or did nothing. Finally, participants rated their stress level again. Results: Self-choice emotion regulation reduced stress better than forced-choice emotion regulation. The stress reduction was associated with decreases in the activation of the left opercular part of the inferior frontal gyrus. Conclusions: Self-choice can improve emotion regulation, and this effect is likely mediated by the neural efficiency of the left inferior frontal gyrus.
Highly demarcated structural alterations in the brain and impaired social incentive learning in Tbx1 heterozygous mice. 国際誌

Takeshi Hiramoto, Akira Sumiyoshi, Risa Kato, Takahira Yamauchi, Takeshi Takano, Gina Kang, Marisa Esparza, Bailey Matsumura, Lucas J Stevens, Yukiko J Hiroi, Takaki Tanifuji, Rie Ryoke, Hiroi Nonaka, Akihiro Machida, Kensaku Nomoto, Kazutaka Mogi, Takefumi Kikusui, Ryuta Kawashima, Noboru Hiroi

Molecular psychiatry　2024年10月27日

DOI： 10.1038/s41380-024-02797-x 　

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Copy number variants (CNVs) are robustly associated with psychiatric disorders and changes in brain structures. However, because CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations in the brains of 22q11.2 CNV carriers have been identified in humans and mouse models, it is unknown how each gene encoded in the 22q11.2 region contributes to structural alterations, associated mental illnesses, and their dimensions. Our previous studies identified Tbx1, a T-box family transcription factor encoded in the 22q11.2 CNV, as a driver gene for social interaction and communication, spatial and working memory, and cognitive flexibility. However, it remains unclear how TBX1 impacts the volumes of various brain regions and their functionally linked behavioral dimensions. In this study, we used volumetric magnetic resonance imaging analysis to comprehensively evaluate brain region volumes and behavioral alterations relevant to affected structures in congenic Tbx1 heterozygous mice. Our data showed that the volumes of the anterior and posterior portions of the amygdaloid complex and its surrounding cortical regions were most robustly reduced in Tbx1 heterozygous mice. In an amygdala-dependent task, Tbx1 heterozygous mice were impaired in their ability to learn the incentive value of a social partner. The volumes of the primary and secondary auditory cortexes were increased, and acoustic, but not non-acoustic, sensorimotor gating was impaired in Tbx1 heterozygous mice. Our findings identify the brain's regional volume alterations and their relevant behavioral dimensions associated with Tbx1 heterozygosity.
Preventive effect of one-session brief focused attention meditation on state fatigue: Resting state functional magnetic resonance imaging study

Noriki Yamaya, Teruo Hashimoto, Shigeyuki Ikeda, Denilson Brilliant T, Masayuki Tsujimoto, Seishu Nakagawa, Ryuta Kawashima

NeuroImage　120709-120709　2024年6月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.neuroimage.2024.120709 　

ISSN：1053-8119
Perceiving humanness across ages: neural correlates and behavioral patterns

Toshiki Saito, Rui Nouchi, Ryo Ishibashi, Kosuke Motoki, Yutaka Matsuzaki, Akiko Kobayashi, Motoaki Sugiura, Ryuta Kawashima

Frontiers in Psychology　15　2024年4月4日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fpsyg.2024.1361588 　

eISSN：1664-1078

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Humanness perception, which attributes fundamental and unique human characteristics to other objects or people, has significant consequences for people’s interactions. Notably, the failure to perceive humanness in older adults can lead to prejudice. This study investigates the effect of a target’s age on humanness perception in terms of two dimensions: agency (the ability to act and do) and experience (the ability to feel and sense). We also examined brain activity using a magnetic resonance imaging (MRI) scanner in order to understand the underlying neural mechanisms. Healthy university students viewed the facial images of older and younger individuals and judged the humanness of each individual in terms of agency and experience while inside the MRI scanner. The results indicated that older adults were rated higher on experience, and no difference was found in ratings for agency between younger and older face images. Analysis of brain imaging data indicated that positive functional connectivity between the ventral and dorsal regions of the medial prefrontal cortex (mPFC) was greater when judging the humanness of younger faces than older faces. We also found that the negative functional connectivity between the left inferior frontal gyrus and postcentral gyrus was greater when judging the humanness of older faces as compared to that of younger faces. Although the current study did not show distinct brain activities related to humanness perception, it suggests the possibility that different brain connectivities are related to humanness perception regarding targets belonging to different age groups.
Predicting conversational satisfaction of face-to-face conversation through interpersonal similarity in resting-state functional connectivity. 国際誌

Shigeyuki Ikeda, Hyeonjeong Jeong, Yukako Sasaki, Kohei Sakaki, Shohei Yamazaki, Takayuki Nozawa, Ryuta Kawashima

Scientific reports　14　(1)　6015-6015　2024年3月12日

DOI： 10.1038/s41598-024-56718-7 　

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When conversing with an unacquainted person, if it goes well, we can obtain much satisfaction (referred to as conversational satisfaction). Can we predict how satisfied dyads will be with face-to-face conversation? To this end, we employed interpersonal similarity in whole-brain resting-state functional connectivity (RSFC), measured using functional magnetic resonance imaging before dyadic conversation. We investigated whether conversational satisfaction could be predicted from interpersonal similarity in RSFC using multivariate pattern analysis. Consequently, prediction was successful, suggesting that interpersonal similarity in RSFC is an effective neural biomarker predicting how much face-to-face conversation goes well. Furthermore, regression coefficients from predictive models suggest that both interpersonal similarity and dissimilarity contribute to good interpersonal relationships in terms of brain activity. The present study provides the potential of an interpersonal similarity approach using RSFC for understanding the foundations of human relationships and new neuroscientific insight into whether success in human interactions is predetermined.
Enhanced memory and hippocampal connectivity in humans 2 days after brief resistance exercise. 国際誌

Teruo Hashimoto, Rikimasa Hotta, Ryuta Kawashima

Brain and behavior　14　(2)　e3436　2024年2月

DOI： 10.1002/brb3.3436 　

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INTRODUCTION: Exercise has significant health benefits and can enhance learning. A single bout of high-intensity resistance training may be sufficient to improve memory. This study aimed to assess memory enhancement by a single bout of high-intensity resistance training and to examine the neural underpinnings using resting-state functional magnetic resonance imaging (MRI). METHODS: Sixty young adults (34 men and 26 women), divided into the training and control groups, participated. The first session included verbal memory recall tests (cued- and free-recall), resting-state functional MRI (rs-fMRI), and a single-bout high-intensity resistance training for the training group. Two days later, they underwent post-intervention memory tests and rs-fMRI. The study design was 2 groups × 2 sessions for memory tests, and within training group comparisons for rs-fMRI. RESULTS: Compared to the control group without resistance training, the training group showed higher cued-recall performance 2 days after the brief resistance training (training: +0.27, control: -0.13, interaction: p = .01), and their free-recall scores were associated with enhanced left posterior hippocampal connectivity (r = .64, p < .001). CONCLUSIONS: These results suggest that brief high-intensity resistance exercise/strength training could enhance memory without repeated exercising. The quick effect of resistance training on memory and hippocampal connectivity could be revealed. A focused and one-shot exercise may be sufficient to enhance memory performance and neural plasticity in a few days.
Effects of pain associated with orthodontic tooth movement on tactile sensation of periodontal ligaments. 国際誌

Eriya Shimada, Hiroyasu Kanetaka, Hiroki Hihara, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato, Kaoru Igarashi

Clinical oral investigations　28　(1)　36-36　2023年12月26日

DOI： 10.1007/s00784-023-05469-2 　

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OBJECTIVES: Pain associated with orthodontic tooth movement reportedly reduces periodontal ligament tactile sensation. However, the mechanism associated with the central nervous system remains unclear. This study was conducted by measuring somatosensory evoked magnetic fields (SEFs) during mechanical stimulation of teeth as they were being moved by separator elastics. Findings clarified the effects of pain on periodontal ligament tactile sensation during orthodontic tooth movement. MATERIALS AND METHODS: Using magnetoencephalography, SEFs were measured during the application of mechanical stimuli to the mandibular right first molars of 23 right-handed healthy participants (0 h). Separator elastics were subsequently inserted into the mesial and distal interdental portions of the mandibular right first molars. The same mechanical stimuli were applied again 24 h later while the SEFs were measured (24 h). After each SEF measurements, pain was also evaluated using the Visual Analog Scale (VAS). RESULTS: The VAS values were significantly higher at 24 h than at 0 h (p < 0.05). No significant difference in the peak latencies was found between those obtained at 0 h and 24 h, but the intensities around 40.0 ms in the contralateral hemisphere were significantly lower at 24 h than at 0 h (p < 0.01). CONCLUSIONS: Pain associated with orthodontic tooth movement might suppress periodontal ligament tactile sensation in the primary somatosensory cortex. CLINICAL RELEVANCE: Pain associated with orthodontic tooth movement might affect periodontal ligament sensation, consequently causing discomfort during occlusion.
Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial. 国際誌

Rui Nouchi, Natasha Y S Kawata, Toshiki Saito, Haruka Nouchi, Ryuta Kawashima

Nutrients　15　(21)　2023年10月30日

DOI： 10.3390/nu15214608 　

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BACKGROUND: Cognitive functions decline with age. Declined cognitive functions negatively affect daily behaviors. Previous studies showed the positive effect of spices and herbs on cognition. In this study, we investigated the positive impact of wasabi, which is a traditional Japanese spice, on cognitive functions. The main bioactive compound of wasabi is 6-MSITC (6 methylsulfinyl hexyl isothiocyanate), which has anti-oxidant and anti-inflammatory functions. Anti-oxidants and anti-inflammatories have an important role in cognitive health. Therefore, 6-MSITC is expected to have positive effects on cognitive function. Previous studies showed the beneficial effects on cognitive functions in middle-aged adults. However, it is unclear that 6-MSITC has a positive effect on cognitive functions in healthy older adults aged 60 years and over. Here, we investigated whether 12 weeks' 6-MSITC intervention enhances cognitive performance in older adults using a double-blinded randomized controlled trial (RCT). METHODS: Seventy-two older adults were randomly assigned to 6-MSITC or placebo groups. Participants were asked to take a supplement (6-MSITC or a placebo) for 12 weeks. We checked a wide range of cognitive performances (e.g., executive function, episodic memory, processing speed, working memory, and attention) at the pre- and post-intervention periods. RESULTS: The 6-MSITC group showed a significant improvement in working and episodic memory performances compared to the placebo group. However, we did not find any significant improvements in other cognitive domains. DISCUSSION: This study firstly demonstrates scientific evidence that 6-MSITC may enhance working memory and episodic memory in older adults. We discuss the potential mechanism for improving cognitive functions after 6-MSITC intake.
Neural representation of a one-week delay in remembering information after production and self-generated elaboration encoding strategy

Ryo Nakamura, Rui Nouchi, Ayano Yagi, Noriki Yamaya, Masaya Ota, Minami Ishigooka, Ryuta Kawashima

Acta Psychologica　240　104051-104051　2023年10月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.actpsy.2023.104051 　

ISSN：0001-6918
Language MEG predicts postoperative verbal memory change in left mesial temporal lobe epilepsy

Ryuzaburo Kochi, Shin-ichiro Osawa, Kazutaka Jin, Makoto Ishida, Akitake Kanno, Masaki Iwasaki, Kyoko Suzuki, Ryuta Kawashima, Teiji Tominaga, Nobukazu Nakasato

Clinical Neurophysiology　2023年10月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.clinph.2023.09.010 　

ISSN：1388-2457
Right amygdala and caudate activation patterns predict implicit attitudes toward people with autism spectrum disorders and physical disabilities, respectively

Susumu Yokota, Teruo Hashimoto, Yutaka Matsuzaki, Shigeyuki Ikeda, Ryuta Kawashima

Cognitive, Affective, & Behavioral Neuroscience　2023年9月19日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.3758/s13415-023-01126-z 　

ISSN：1530-7026

eISSN：1531-135X
Effects of adult education on cognitive function and risk of dementia in older adults: a longitudinal analysis 査読有り

Takeuchi H, Kawashima R

Frontiers in Aging Neuroscience　15　2023年8月

DOI： 10.3389/fnagi.2023.1212623 　
Social-coalitional trait is related to coping capacity with mortality threat: association with leadership and a reduced parietal response to mortality salience

Kanan Hirano, Kentaro Oba, Toshiki Saito, Ryuta Kawashima, Motoaki Sugiura

Frontiers in Behavioral Neuroscience　17　2023年7月13日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fnbeh.2023.1188878 　

eISSN：1662-5153

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Introduction Coping with mortality threat, a psychological threat unique to humans and distinct from general emotional distress, is traditionally characterized by immediate suppression and prolonged worldview defense within the framework of the influential terror management theory (TMT). Views regarding the personality-trait concepts for this coping capacity diverge: some favor a broad definition based on general psychological attitudes (e.g., hardiness), while others prefer a narrow definition linked to interpersonal attitudes related to social coalition (e.g., attachment style and self-transcendence). Methods Using functional MRI, we presented healthy older participants with death-related words and explored correlations between the neural responses to mortality threat and the factor scores of the Power to Live questionnaire, which measures eight resilience-related psychobehavioral traits. Results We observed a significant association between the factor score and a neural response only for leadership; individuals with a high leadership score exhibited reduced neural response to mortality salience in the right inferior parietal lobule. Discussion Within the TMT framework, our findings align with the concept of the immediate suppression of death-thought accessibility associated with a secure attachment style, a trait conceptually linked to leadership. These findings highlight the unique role for the narrowly defined social-coalitional trait during the immediate stage of the coping process with mortality salience, in contrast to the broadly defined resilience-related personality traits associated with a prolonged worldview defense process. The deterioration of this coping process could constitute a distinct aspect of psychopathology, separate from dysfunction in general emotion regulation.
fMRI reveals the dynamic interface between explicit and implicit knowledge recruited during elicited imitation task 査読有り

Yuichi Suzuki†, Hyeonjeong Jeong†, Cui Haining, Kiyo Okamoto, Ryuta Kawashima, Motoaki Sugiura

Research Methods in Applied Linguistics　2　(2)　100051　2023年6月1日

DOI： 10.1016/j.rmal.2023.100051 　
Brain activation and functional connectivity of reappraisal and acceptance for anxious events

Masayuki Tsujimoto, Yutaka Matsuzaki, Noriki Yamaya, Ryuta Kawashima

eneuro　10　(6)　ENEURO.0033-23.2023　2023年5月23日
出版者・発行元： Society for Neuroscience
DOI： 10.1523/eneuro.0033-23.2023 　

eISSN：2373-2822

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Despite the significant health consequences of anxiety, the neural basis of regulation for personal anxious events is not well understood. We compared brain activity and functional connectivity during cognitive emotion regulation strategies (reappraisal and acceptance) for personal anxious events. Functional MRI data were obtained while 35 college students were thinking about (the control condition), reappraising, or accepting their own anxiety-provoking situations. Although reappraisal and acceptance decreased anxiety, no statistically significant differences were observed in the brain activation levels between cognitive emotion regulation strategies and the control condition. However, acceptance decreased activation in the posterior cingulate cortex and precuneus more than reappraisal. Moreover, functional connectivity with the amygdala and ventral anterior insula distinguished the emotion regulation strategies for anxiety. Reappraisal showed stronger negative functional connectivity with the amygdala and cognitive control regions than other strategies. In addition, reappraisal had negative functional coupling between the ventral anterior insula and temporal pole compared with acceptance. In contrast, acceptance showed stronger positive functional coupling between the ventral anterior insula and precentral and postcentral gyrus compared with the control condition. Our findings contribute to the understanding of emotion regulation processes by revealing the brain activity and functional connectivity patterns in reappraisal and acceptance for personal anxious events. Significance statement This study is the first to reveal the differences in brain activity and functional connectivity between reappraisal and acceptance for individual anxious events. We found that reappraisal strengthened the negative functional coupling between the cognitive control areas and emotion-processing regions. In contrast, acceptance was characterized by a reduction in the self-reflection process and strengthened the functional coupling between emotion-processing regions and self-reflective and emotion recognition areas. These results contribute to a better understanding of emotion regulation processes by providing the differences in relationships of activation in self-reflection, cognitive control, and emotion-processing regions between reappraisal and acceptance for personal anxious events. These findings may help discover interventions for mitigating the negative effects of anxiety.
Possibility of additive effects by the presentation of visual information related to distractor sounds on the contra-sound effects of the N100m responses. 国際誌

Shunsuke Takai, Akitake Kanno, Tetsuaki Kawase, Masayuki Shirakura, Jun Suzuki, Nobukatsu Nakasato, Ryuta Kawashima, Yukio Katori

Hearing research　434　108778-108778　2023年4月23日

DOI： 10.1016/j.heares.2023.108778 　

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Auditory-evoked responses can be affected by different types of contralateral sounds or by attention modulation. The present study examined the additive effects of presenting visual information about contralateral sounds as distractions during dichotic listening tasks on the contralateral effects of N100m responses in the auditory-evoked cortex in 16 subjects (12 males and 4 females). In magnetoencephalography, a tone-burst of 500 ms duration at a frequency of 1000 Hz was played to the left ear at a level of 70 dB as a stimulus to elicit the N100m response, and a movie clip was used as a distractor stimulus under audio-only, visual-only, and audio-visual conditions. Subjects were instructed to pay attention to the left ear and press the response button each time they heard a tone-burst stimulus in their left ear. The results suggest that the presentation of visual information related to the contralateral sound, which worked as a distractor, significantly suppressed the amplitude of the N100m response compared with only the contralateral sound condition. In contrast, the presentation of visual information related to contralateral sound did not affect the latency of the N100m response. These results suggest that the integration of contralateral sounds and related movies may have resulted in a more perceptually loaded stimulus and reduced the intensity of attention to tone-bursts. Our findings suggest that selective attention and saliency mechanisms may have cross-modal effects on other modes of perception.
Motivational decline and proactive response under thermal environmental stress are related to emotion- and problem-focused coping, respectively: Questionnaire construction and fMRI study

Kelssy Hitomi dos Santos Kawata, Kanan Hirano, Yumi Hamamoto, Hajime Oi, Akitake Kanno, Ryuta Kawashima, Motoaki Sugiura

Frontiers in Behavioral Neuroscience　17　2023年4月12日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fnbeh.2023.1143450 　

eISSN：1662-5153

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Despite the diversity of human behavioral and psychological responses to environmental thermal stress, the major dimensions of these responses have not been formulated. Accordingly, the relevance of these responses to a framework of coping with stress (i.e., emotion- and problem-focused) and the neural correlates are unexplored. In this study, we first developed a multidimensional inventory for such responses using social surveys and a factor analysis, and then examined the neural correlates of each dimension using a functional magnetic resonance imaging; we manipulated the ambient temperature between uncomfortably hot and cold, and the correlations between the inventory factor scores and discomfort-related neural responses were examined. We identified three factors to construct the inventory: motivational decline, proactive response, and an active behavior, which appeared to reflect inefficient emotion-focused coping, efficient problem-focused coping, and positive appreciation of extreme environmental temperatures, respectively, under environmental thermal stress. Motivational decline score was positively associated with common neural response to thermal stress in the frontal and temporoparietal regions, implicated in emotion regulation, while proactive response score negatively with the neural responses related to subjective discomfort in the medial and lateral parietal cortices, implicated in problem-solving. We thus demonstrated that two of three major dimensions of individual variation in response to and coping with environmental thermal stress conform to an influential two-dimensional framework of stress coping. The current three-dimensional model may expand the frontiers of meteorological human science in both basic and application domains.
A consensus protocol for functional connectivity analysis in the rat brain. 国際誌

Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A Barrière, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M Cardoso, Marina Célestine, Jorge E Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvořáková, Claudia Falfán-Melgoza, Francisca F Fernandes, Caitlin F Fowler, Antonio Fuentes-Ibañez, Clément M Garin, Eveline Gelderman, Carla E M Golden, Chao C G Guo, Marloes J A G Henckens, Lauren A Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y Liu, Alejandra López-Castro, Xavier López-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M P Naessens, Laura J Nava-Gomez, Hiroi Nonaka, Juan J Ortiz, Jaakko Paasonen, Lore M Peeters, Mickaël Pereira, Pablo D Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Pérez, Gabriele Russo, Tobias J Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G Sanganahalli, Aileen Schroeter, Bhedita J Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A B Smith, Corrie Smith, Filip Sobczak, Petteri J Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E Torres-García, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T B van Hout, Roberta Vertullo, Benjamin Vidal, Roël M Vrooman, Victora X Wang, Isabel Wank, David J G Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P Auer, Emmanuel L Barbier, Jürgen Baudewig, Christian F Beckmann, Nicolau Beckmann, Guillaume J P C Becq, Erwin L A Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F Coolen, Jeffrey W Dalley, Marc Dhenain, Rick M Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W Feindel, Gianluigi Forloni, Jérémie Fouquet, Eduardo A Garza-Villarreal, Natalia Gass, Jeffrey C Glennon, Alessandro Gozzi, Olli Gröhn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R Homberg, Danielle J Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D Keilholz, Georgios A Keliris, Clare Kelly, Christian Kerskens, Jibran Y Khokhar, Peter C Kind, Jean-Baptiste Langlois, Jason P Lerch, Monica A López-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B Mars, Gerardo Marsella, Edoardo Micotti, Emma Muñoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M Otte, Patricia Pais-Roldán, Wen-Ju Pan, Roberto A Prado-Alcalá, Gina L Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J Sawiak, Tom W J Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J Thompson, Sally M Till, Nick Todd, Annemie Van Der Linden, Annette van der Toorn, Geralda A F van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B Zhang, Luc Zimmer, Gabriel A Devenyi, M Mallar Chakravarty, Andreas Hess

Nature neuroscience　26　(4)　673-681　2023年4月

DOI： 10.1038/s41593-023-01286-8 　

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Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.
The Effect of Cognitive Training with Neurofeedback on Cognitive Function in Healthy Adults: A Systematic Review and Meta-Analysis

Yutaka Matsuzaki, Rui Nouchi, Kohei Sakaki, Jérôme Dinet, Ryuta Kawashima

Healthcare　11　(6)　843-843　2023年3月13日
出版者・発行元： MDPI AG
DOI： 10.3390/healthcare11060843 　

eISSN：2227-9032

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Background: Cognitive training aims to improve cognitive function through cognitive tasks or training games. Neurofeedback is a technique to monitor brain signals with either visual or auditory feedback. Previous studies suggest that a combination of cognitive training and neurofeedback has a superior effect on cognitive functions compared with cognitive training alone. However, no systematic reviews and meta-analyses of the benefits of cognitive training with neurofeedback (CTNF) exist. The purpose of this study was to examine the beneficial effects of CTNF in healthy adults using a systematic review and multilevel meta-analysis. Methods: PubMed, Scopus, PsychoINFO, and MEDLINE were searched for research papers reporting the results of interventions using CTNF. Results: After an initial screening of 234 records, three studies using near-infrared spectroscopy (NIRS) and one study using electroencephalography were extracted from the database. We performed a multi-level meta-analysis with three NIRS studies including 166 participants (mean ages ranged from 21.43 to 65.96 years). A multi-level meta-analysis revealed that CTNF has a beneficial effect on the episodic, long-term, and working memory domains. Conclusions: Although three studies were included in the systematic review and meta-analysis, our results indicate that CTNF using NIRS would lead to improvements in memory functioning.
Automatic adaptive emotion regulation is associated with lower emotion-related activation in the frontoparietal cortex and other cortical regions with multi-componential organization

Motoaki Sugiura, Yoko Katayori, Tomohiko Muratsubaki, Miyuki Shiratori, Sugiko Hanawa, Keyvan Kashkouli Nejad, Daisaku Tamura, Ryuta Kawashima, Shin Fukudo

Frontiers in Behavioral Neuroscience　17　2023年3月6日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fnbeh.2023.1059158 　

eISSN：1662-5153

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Although some researchers consider automatic adaptive emotion regulation to be an automatized strategy whereas others consider it to be implicit disengagement of deliberative process, to date, its neural correlates have been poorly investigated. In addition, the valence specificity of automatic adaptive emotion regulation and levels of activation relative to the neutral condition are controversial; the former is relevant to the attribution of resilient emotion regulation to positivity bias or emotional stability, and the latter to determining whether regulation is based on emotion-specific or emotion-non-specific processes. In this functional magnetic resonance imaging (fMRI) study, we presented positive and negative emotional pictures to healthy young participants and investigated the neural correlates of automatic adaptive emotion regulation in spontaneous emotional response. A significant negative trait effect (i.e., regression coefficient) on activation was identified both for positive and negative emotional responses in various cortical regions. A cluster analysis identified three clusters among these regions based on the valence specificity of the trait effect and level of activation relative to neutral stimuli. Cluster 1 included regions in the sensorimotor cortex characterized by negative emotion-specific decreases in activation relative to neutral stimuli in adaptive individuals. Cluster 2 included several cortical regions including the bilateral dorsal executive network, anterior cingulate, and inferior frontal gyrus, which were characterized by valence-independent decreases in activation in adaptive individuals. Cluster 3 included the bilateral ventrolateral and dorsomedial prefrontal cortices, right insula, and other posterior regions, which were characterized by increased activation for negative stimuli in non-adaptive individuals. These findings support the assumption that automatic adaptive emotion regulation involves the implicit disengagement of deliberative process and suggest the relevance of different cortical networks to the potential emotion- and valence-specificity of adaptive regulation.
Effects of television viewing on brain structures and risk of dementia in the elderly: longitudinal analyses 招待有り査読有り

Takeuchi H, Kawashima R

Frontiers in Neuroscience　17　article-984919　2023年3月

DOI： 10.3389/fnins.2023.984919. 　
Sincere praise and flattery: reward value and association with the praise-seeking trait

Shotaro Fujiwara, Ryo Ishibashi, Azumi Tanabe-Ishibashi, Ryuta Kawashima, Motoaki Sugiura

Frontiers in Human Neuroscience　17　2023年2月15日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fnhum.2023.985047 　

eISSN：1662-5161

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Sincere praise reliably conveys positive or negative feedback, while flattery always conveys positive but unreliable feedback. These two praise types have not been compared in terms of communication effectiveness and individual preferences using neuroimaging. Through functional magnetic resonance imaging, we measured brain activity when healthy young participants received sincere praise or flattery after performing a visual search task. Higher activation was observed in the right nucleus accumbens during sincere praise than during flattery, and praise reliability correlated with posterior cingulate cortex activity, implying a rewarding effect of sincere praise. In line with this, sincere praise uniquely activated several cortical areas potentially involved in concern regarding others’ evaluations. A high praise-seeking tendency was associated with lower activation of the inferior parietal sulcus during sincere praise compared to flattery after poor task performance, potentially reflecting suppression of negative feedback to maintain self-esteem. In summary, the neural dynamics of the rewarding and socio-emotional effects of praise differed.
Nutrients and Dementia: Prospective Study 招待有り査読有り

Takeuchi H, Kawashima R

Nutrients　15　(4)　article-842　2023年2月

DOI： 10.3390/nu15040842. 　
Neural mechanisms of perceptual and affective body-image disturbance during own-body and ideal-body estimation

Yumi Hamamoto, Shinsuke Suzuki, Kosuke Motoki, Kentaro Oba, Ryuta Kawashima, Motoaki Sugiura

Behavioural Brain Research　114349-114349　2023年2月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.bbr.2023.114349 　

ISSN：0166-4328
Acute Benefits of Acidified Milk Drinks with 10-g and 15-g Protein on Shifting and Updating Performances in Young Adults: A Randomized Controlled Trial. 国際誌

Rui Nouchi, Laurie T Butler, Daniel Lamport, Haruka Nouchi, Ryuta Kawashima

Nutrients　15　(2)　2023年1月13日

DOI： 10.3390/nu15020431 　

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BACKGROUND: Accumulating evidence has shown that protein-rich milk drinks can rapidly improve cognitive performance. However, the optimum doses of milk protein that are needed to improve cognitive function remain to be investigated. OBJECTIVE: This study aimed to determine whether acidified milk drinks with 10-g and 15-g milk protein have acute benefits on key cognitive functions in healthy young adults. DESIGN: In this double-blinded randomized control trial, 66 young adults were randomly assigned to one of three groups (0-g, 10-g, and 15-g milk protein groups). Key cognitive functions (processing speed, inhibition, shifting, updating, and working memory capacity) were assessed before and 15 and 60 min after the drink intake. RESULTS: We found that the shifting performance improved at 15 min after intake of the acidified 10-g and 15-g milk protein drinks compared to intake of the 0-g milk protein drink, and this acute effect of the acidified 15-g milk protein drink lasted for 60 min. In addition, updating performance improved at 60 min after intake of the acidified 10-g and 15-g milk protein drinks compared to intake of the 0-g milk protein drink. CONCLUSION: Our findings suggest that the acidified 10-g and 15-g milk protein drinks have an acute benefit on shifting and updating performance in healthy young adults.
Disappearance and Re-Emergence of Influenza during the COVID-19 Pandemic: Association with Infection Control Measures

Hikaru Takeuchi, Ryuta Kawashima

Viruses　15　(1)　223-223　2023年1月13日
出版者・発行元： MDPI AG
DOI： 10.3390/v15010223 　

eISSN：1999-4915

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During the coronavirus disease 2019 (COVID-19) pandemic, the influenza virus had a very low prevalence, and in many areas, outbreaks were almost non-existent. In this study, the associations between infection control measures taken for COVID-19 and the global disappearance of the influenza virus were investigated. The detection rate of influenza from baseline was investigated during four seasons (12 weeks from epidemiological week 49 in 2020 and 2021 and 12 weeks from epidemiological week 23 in 2020 and 2021) in each country participating in the surveillance system of the World Health Organization. Three measures of infection control: mask use ratio, social distancing index (an index of human mobility and physical distance obligations), and an index of stringency of measures taken by authorities were studied. In mid-2020, most countries analyzed had high levels of infection control measures, and in most countries, influenza was drastically reduced compared to previous years. Multiple regression analyses compared the study data with data from other seasons. There was an association between high mask use with low influenza detection in all three remaining seasons, an association between a low social distancing index (low mobility and more social contact obligations) with a low influenza detection rate in two seasons, and a marginal significant association of high stringency index with a low influenza detection rate(in 2020-end-seasons). These results support the notion that seasonal influenza is controllable through effective preventive measures, especially those of mask use and human social contact, and these measures should be recommended during future waves of novel influenza virus infection.
Temporal Changes in the State Effect of Meditation on Response Inhibition Processes

Noriki Yamaya, Shigeyuki Ikeda, Yuichi Hoshino, Hikaru Takeuchi, Ryuta Kawashima

Mindfulness　2023年1月10日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s12671-022-02064-6 　

ISSN：1868-8527

eISSN：1868-8535

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Abstract Objectives A single session of brief focused attention meditation (FAM) has a state effect, which temporarily enhances response inhibition processes. However, previous research has two unanswered questions: (i) How long does the state effect last? (ii) How does effort toward FAM relate to the resulting state effect? Method Thirty-nine healthy participants participated in two sessions: FAM and sham meditation (SHAM). The participants conducted each meditation for 10 min. The state effect on response inhibition processes was observed as Stroop task performance immediately before and after each meditation, and 20, 40, and 60 min after each meditation. In addition, the subjective effort toward meditation was evaluated using a questionnaire immediately after each meditation. Results An analysis of variance revealed a significant interaction between session and time. In the post-hoc analysis, FAM showed significantly better Stroop task performance than the SHAM 60 min after meditation. Furthermore, using correlational analysis, we found that at 60 min, the higher the subjective effort, the better Stroop task performance. Conclusions In contrast to previous findings, the state effect was not found immediately after FAM but instead 60 min after. The results can be partially explained by cognitive fatigue; that is, the FAM may have the state effect of preventing cognitive fatigue. This state effect is greater when the subjective effort is greater.
Dynamic functional connectivity associated with prospective memory success in children

Teruo Hashimoto, Susumu Yokota, Satoshi Umeda, Ryuta Kawashima

Neuroimage: Reports　2　(4)　2022年12月

DOI： 10.1016/j.ynirp.2022.100144 　

eISSN：2666-9560
Mercury levels in hair are associated with reduced neurobehavioral performance and altered brain structures in young adults

Hikaru Takeuchi, Yuka Shiota, Ken Yaoi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Communications Biology　5　(1)　2022年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s42003-022-03464-z 　

eISSN：2399-3642

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Abstract The detrimental effects of high-level mercury exposure on the central nervous system as well as effects of low-level exposure during early development have been established. However, no previous studies have investigated the effects of mercury level on brain morphometry using advance imaging techniques in young adults. Here, utilizing hair analysis which has been advocated as a method for biological monitoring, data of regional gray matter volume (rGMV), regional white matter volume (rWMV), fractional anisotropy (FA) and mean diffusivity (MD), cognitive functions, and depression among 920 healthy young adults in Japan, we showed that greater hair mercury levels were weakly but significantly associated with diminished cognitive performance, particularly on tasks requiring rapid processing (speed measures), lower depressive tendency, lower rGMV in areas of the thalamus and hippocampus, lower rWMV in widespread areas, greater FA in bilaterally distributed white matter areas overlapping with areas of significant rWMV reductions and lower MD of the widely distributed gray and white matter areas particularly in the bilateral frontal lobe and the right basal ganglia. These results suggest that even normal mercury exposure levels in Japan are weakly associated with differences of brain structures and lower neurobehavioral performance and altered mood among young adults.
Academic achievements and brain volume development in children and adolescents

Teruo Hashimoto, Yutaka Matsuzaki, Susumu Yokota, Ryuta Kawashima

Cerebral Cortex Communications　2022年11月16日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/texcom/tgac048 　

eISSN：2632-7376

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Abstract Children are expected to acquire both basic and numeric skills. Achievement of higher levels of reading, writing, arithmetic, and vocabulary are favorable and desirable. The relationship between each literacy skill and neural development has been investigated; however, association between brain development and the four literacy skills has not been examined. This longitudinal, structural, neuroimaging study explored the contribution of higher academic achievement in reading, writing, arithmetic, and vocabulary to neural development. The brain volumes of children and adolescents aged 9–16 years were measured in the first test. Approximately 2.6 years later, the brain volumes and four academic achievement scores of 77 participants were measured in the second test. Changes in the gray matter volume in the left fusiform gyrus were associated with vocabulary scores, while those in the left striatum were associated with arithmetic scores. The reading and writing scores showed no statistically significant relationship with changes in brain volume. The current vocabulary score correlated with current gray matter volume, while brain volumes in the first test showed no association with any achievement scores. These results suggest that academic achievement may modulate brain plasticity in various ways.
The effect of action contingency on social perception is independent of person-like appearance and is related to deactivation of the frontal component of the self-agency network. 国際誌

Yumi Hamamoto, Yukiko Takahara, Kelssy Hitomi Dos Santos Kawata, Tatsuo Kikuchi, Shinsuke Suzuki, Ryuta Kawashima, Motoaki Sugiura

Scientific reports　12　(1)　17326-17326　2022年10月15日

DOI： 10.1038/s41598-022-22278-x 　

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The detection of object movement that is contingent on one's own actions (i.e., movements with action contingency) influences social perception of the object; such interactive objects tend to create a good impression. However, it remains unclear whether neural representation of action contingency is associated with subsequent socio-cognitive evaluation of "contacting agents", or whether the appearance of agents (e.g., face- or non-face-like avatars) is essential for this effect. In this study, we conducted a functional magnetic resonance imaging (fMRI) task with two phases: contact (contact with face- or non-face-like avatars moving contingently or non-contingently) and recognition (rating a static image of each avatar). Deactivation of the frontoparietal self-agency network and activation of the reward network were the main effects of action contingency during the contact phase, consistent with previous findings. During the recognition phase, static avatars that had previously moved in a contingent manner deactivated the frontal component of the frontoparietal network (bilateral insula and inferior-middle frontal gyri), regardless of person-like appearance. Our results imply that frontal deactivation may underlie the effect of action contingency on subsequent social perception, independent of person-like appearance.
Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip

Chihiro Kitayama, Eriya Shimada, Hiroki Hihara, Akitake Kanno, Nobukazu Nakasato, Yoshimichi Imai, Akimitsu Sato, Ryuta Kawashima, Kaoru Igarashi, Hiroyasu Kanetaka

PLOS ONE　17　(9)　e0274405-e0274405　2022年9月22日
出版者・発行元： Public Library of Science (PLoS)
DOI： 10.1371/journal.pone.0274405 　

eISSN：1932-6203

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Background Cleft lip is the most common congenital anomaly worldwide. Nevertheless, lip somatosensory characteristics of patients with cleft lip after cheiloplasty have not yet been determined. The present study used magnetoencephalography to objectively evaluate the lip sensation in patients with unilateral cleft lip to establish a new objective evaluation method. Methods Participants were 15 patients with unilateral cleft lip after cheiloplasty (UCL group), and 30 healthy young subjects (control group). Five points of the upper and lower lips were stimulated electrically to measure somatosensory evoked magnetic fields (SEFs). The sources of the magnetic fields were modeled as single equivalent current dipoles (ECDs). ECDs located on the central sulcus by superimposition on magnetic resonance images were analyzed. Latency and intensity at 50–75 ms (cP60m) observed in the UCL group were compared with those in the control group. Thresholds of tactile stimuli in both groups were obtained using Semmes–Weinstein monofilaments for subjective sensory evaluation. Results No significant difference was found in the intensity of the cP60m or subjective evaluation between the groups. However, the latency of the cP60m was significantly longer in the upper lip of the UCL group than in the control group. Conclusions SEFs showed a difference in lip sensation between the UCL group and the control group, suggesting that longer latency might be caused by the effects of surgical scarring on the neurotransmission pathway. These results suggest SEFs as useful for the objective evaluation of lip sensations. This study might improve future surgical procedures and lip functions of patients with cleft lip.
Brain Anatomy Alterations and Mental Health Challenges Correlate to Email Addiction Tendency

Saeid Sadeghi, Hikaru Takeuchi, Bita Shalani, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Brain Sciences　12　(10)　1278-1278　2022年9月22日
出版者・発行元： MDPI AG
DOI： 10.3390/brainsci12101278 　

eISSN：2076-3425

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Despite the widespread use of email, our knowledge regarding the consequences of email addiction is lacking. The purpose of this study was to develop an email addiction tendency scale to evaluate its correlation to behavior and brain structure. Following this, the validity and reliability of the developed scale was investigated. We used voxel-based morphometry, correlation, and univariate regression analysis to assess the relationships between email addiction tendency scores and regional gray and white matter volumes, depression, and nonverbal reasoning abilities in a large sample of healthy young adults (n = 1152; mean age, 20.69 ± 1.84 years). The content validity ratio, content validity index, principal component analysis, and confirmatory factorial analysis all showed that the email addiction tendency scale (EATS) has high validity. Additionally, the Cronbach’s alpha internal consistency and split-half reliability coefficient showed that the EATS has high reliability. We found that email addiction tendency scores were significantly negatively correlated with nonverbal reasoning. We also observed that the email addiction tendency scores were significantly and positively correlated with depression symptom severity and gray matter volume of the left rostrolateral prefrontal cortex (RLPC) in subjects. These results indicate that email addiction tendency is associated with lower mental health outcomes and increased GMV in the left RLPC.
Sex interaction of white matter microstructure and verbal IQ in corpus callosum in typically developing children and adolescents. 国際誌

Susumu Yokota, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

Brain & development　44　(8)　531-539　2022年9月

DOI： 10.1016/j.braindev.2022.04.003 　

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BACKGROUND: Childhood is an extremely important time for neural development that has a critical role in human intelligence. Efficient information processing is crucial for higher intelligence, so the intra- or inter-hemispheric interaction is vital. However, the relationship between neuroanatomical connections and intelligence in typically developing children, as well as sex differences in this relationship, remains unknown. METHODS: Participants were 253 typically developing children (121 boys and 132 girls) aged 5-18. We acquired diffusion tensor imaging data and intelligence using an age-appropriate version of the IQ test; Wechsler Intelligence Scale for Children (WISC) or Wechsler Adult Intelligence Scale (WAIS). We conducted whole-brain multiple regression analysis to investigate the association between fractional anisotropy (FA), which reflects white matter microstructural properties, and each composite score of IQ test (full-scale IQ, performance IQ, and verbal IQ). RESULTS: FA was positively correlated with full-scale IQ in bilateral inferior occipitofrontal fasciculus, genu, and splenium of corpus callosum (CC). FA in the right superior longitudinal fasciculus, bilateral inferior longitudinal fasciculus, and splenium of CC were also positively correlated with performance IQ. Furthermore, we found significant sex interaction between FA in the CC and verbal IQ. FA was positively correlated in boys, and negatively correlated in girls. CONCLUSION: Results suggest that efficient anatomical connectivity between parietal and frontal regions is crucial for children's intelligence. Moreover, inter-hemispheric connections play a critical role in verbal abilities in boys.
【視覚誘発電位・磁界、聴覚誘発電位・磁界】聴性誘発脳磁界(N1m) 音楽による影響と選択的注意

白倉真之, 川瀬哲明, 菅野彰剛, 太田淳, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学　50　(4)　138-142　2022年8月
出版者・発行元： (一社)日本臨床神経生理学会
ISSN：1345-7101

eISSN：2188-031X
【視覚誘発電位・磁界、聴覚誘発電位・磁界】聴性誘発脳磁界(N1m) 音楽による影響と選択的注意

白倉真之, 川瀬哲明, 菅野彰剛, 太田淳, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学　50　(4)　138-142　2022年8月
出版者・発行元： (一社)日本臨床神経生理学会
ISSN：1345-7101

eISSN：2188-031X
Somatosensory Evoked Magnetic Fields Induced by Electrical Palate Stimulation in Patients with Unilateral Cleft Lip and Palate after Palatoplasty

Eriya Shimada, Hiroki Hihara, Chihiro Kitayama, Akitake Kanno, Ryuta Kawashima, Akimitsu Sato, Yoshimichi Imai, Nobukazu Nakasato, Kaoru Igarashi, Hiroyasu Kanetaka

Neuroscience Research　184　30-37　2022年8月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.neures.2022.08.002 　

ISSN：0168-0102
Effects of Body Mass Index on Brain Structures in the Elderly: Longitudinal Analyses

Hikaru Takeuchi, Ryuta Kawashima

Frontiers in Endocrinology　13　2022年6月3日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fendo.2022.824661 　

eISSN：1664-2392

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The relationship between obesity and neurocognitive consequences is complex. Here we investigated associations between body mass index (BMI) and subsequent changes in brain structures, cognitive changes, and the onset of dementia after adjustment of a wide range of potential confounding variables using a large prospective cohort data of UK Biobank. After correcting for confounding factors, higher BMI was associated with greater retention in visuospatial memory performance (decline in error numbers) [beta = -0.019 (CI:-0.027~-0.016), N = 39191], increase in depression tendency scores [beta = 0.036(0.027~0.045)] as well as decreased risk of incident dementia [increasing BMI by 1 is associated with HR of 0.981 (CI:0.969~0.992), N = 398782], but not changes in fluid intelligence or reaction time. Whole brain multiple regression analyses (volumetric analyses: N = 1253, other analyses: N = 1241) revealed positive associations between BMI and subsequent changes in regional gray matter volume (rGMV) in multiple areas, regional white matter volume changes in widespread white matter (WM) tracts, fractional anisotropy changes in several tracts, and intracellular volume fraction (ICVF) and orientation dispersion (OD) in widespread areas, and isotropic volume fraction (ISOVF) in a few areas, and negative associations between BMI and subsequent changes in rGMV in the bilateral medial temporal lobe areas, mean, axial and radial diffusivity, and ISOVF in widespread areas. These results are mostly consistent with the view that less BMI precedes greater neurocognitive aging or atrophy, with a few exceptions including OD findings and the rGMV finding of the medial temporal lobes as most of significant longitudinal associations of higher BMI were opposite to those seen in higher age and dementia. Future epidemiological studies should consider separating effects of higher BMI itself from potential confounders.
Morphological comparison of masseter muscle fibres in the mandibular rest and open positions using diffusion tensor imaging. 国際誌

Takehiko Sugano, Toru Ogawa, Nobuhiro Yoda, Teruo Hashimoto, Kenta Shobara, Kuniyasu Niizuma, Ryuta Kawashima, Keiichi Sasaki

Journal of oral rehabilitation　49　(6)　608-615　2022年6月

DOI： 10.1111/joor.13319 　

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BACKGROUND: The masseter muscle has a complicated multipennate internal structure and exhibits functional differentiation when performing various stomatognathic functions. It is important to understand the internal structural changes of the muscle during functioning to elucidate characteristic muscle disorders such as local myalgia. Diffusion tensor imaging (DTI) may be useful for investigating the internal structural features of muscle. OBJECTIVES: To evaluate the features of masseter muscle fibres in human participants using DTI fibre tractography, and to elucidate the structural differences in the masseter muscle between the mandibular rest and open positions. METHODS: Five healthy men (age 31 ± 7 years) underwent DTI and T1-weighted MRI of the right masseter muscle in the mandibular rest and open positions. MR images were used as a reference for muscle layer segmentation (superficial, intermediate, and deep). DTI fibre tractography of the masseter muscle was performed and the orientation of the DTI fibres was analysed in each layer using coordinates based on the Frankfurt horizontal plane. RESULTS: The DTI fibre orientation of the deep layer significantly changed between the mandibular rest and open positions in the frontal plane (p < 0.05, Wilcoxon rank sum test). However, no significant change was found in the superficial and intermediate layers. CONCLUSION: DTI fibre tractography confirmed regional differences in the orientation change of the masseter muscle fibres between different mandibular positions. The results may support the existence of functional partitioning inside the masseter muscle and suggest that DTI may be useful for the evaluation of muscle fibres in multipennate muscles.
Common and distinct neural bases of multiple positive emotion regulation strategies: A functional magnetic resonance imaging study. 国際誌

Masayuki Tsujimoto, Toshiki Saito, Yutaka Matsuzaki, Risako Kojima, Ryuta Kawashima

NeuroImage　257　119334-119334　2022年5月26日

DOI： 10.1016/j.neuroimage.2022.119334 　

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Appropriate emotion regulation is crucially involved in mental and physical health. The neural basis of negative but not positive emotion regulation has been well investigated. Several strategies should be compared to elucidate the neural correlates of positive emotion regulation. However, there are no studies on multiple positive emotion regulation strategies. We aimed to investigate the neural correlates of positive emotion regulation with multiple emotion regulation strategies and identify common and differential brain areas involved in positive emotion upregulation. We acquired functional magnetic resonance imaging data from healthy college student volunteers while they upregulated positive emotions through instructed strategies or by viewing positive pictures. The instructed strategies included Attentional Deployment, Cognitive Change, and Response Modulation. These strategies increased subjective positive emotions and activation of the prefrontal cortex (PFC) and anterior cingulate cortex (ACC). Region of interest analysis revealed greater activation of the ventral striatum during positive emotion regulation. There are different networks involved in Cognitive Change and Response Modulation. Our findings indicate that multiple strategies for positive emotion upregulation involve common (e.g., PFC, ACC, and ventral striatum) and unique networks.
Neuroendocrine Response and State Anxiety Due to Psychosocial Stress Decrease after a Training with Subject's Own (but Not Another) Virtual Body: An RCT Study. 国際誌

Dalila Burin, Gabriele Cavanna, Daniela Rabellino, Yuka Kotozaki, Ryuta Kawashima

International journal of environmental research and public health　19　(10)　2022年5月23日

DOI： 10.3390/ijerph19106340 　

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Previous research involving healthy participants has reported that seeing a moving virtual body from the first person perspective induces the illusion of ownership and agency over that virtual body. When a person is sitting and the virtual body runs, it is possible to measure physiological, behavioral and cognitive reactions that are comparable to those that occur during actual movement. Capitalizing on this evidence, we hypothesized that virtual training could also induce neuroendocrine effects that prompt a decreased psychosocial stress response, as occurs after physical training. While sitting, 26 healthy young adults watched a virtual avatar running for 30 min from the first person perspective (experimental group), while another 26 participants watched the virtual body from the third person perspective (control group). We found a decreased salivary alpha-amylase concentration (a biomarker for the stress response) after the virtual training among the experimental group only, as well as a decreased subjective feeling of state anxiety (but no difference in heart rate). We argue that the virtual illusion of a moving body from the first person perspective can initiate a cascade of events, from the perception of the visual illusion to physiological activation that triggers other biological effects, such as the neuroendocrine stress response.
A Prospective Study on the Relationship Between Driving and Non-occupational Computer Use With Risk of Dementia

Hikaru Takeuchi, Ryuta Kawashima

Frontiers in Aging Neuroscience　14　2022年5月16日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fnagi.2022.854177 　

eISSN：1663-4365

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Sedentary behaviors have been associated with the risk of dementia in older adults. Whether driving and computer use are associated with the risk of dementia in older adults is an important research question. The participants of a longitudinal cohort study that included European middle- and old-aged adults at the baseline (2006–2010) who had not been diagnosed with dementia before 5 years after the baseline and had not died within 5 years after the baseline were followed up (until 2018) and analyzed. The associations between driving and non-occupational computer use time measured by the questionnaire at the baseline and incident dementia 5 years after the baseline were analyzed after correcting for confounding variables. Each analysis included approximately 370,000 participants and 1,000 cases. According to Cox proportional hazard models that divide subjects into four groups of habit duration levels [(a) 0 h; (b) less than 1 h, 1 h; (c), 2 h, 3 h; (d) 4 h or more, per/day)], the group with 0 h &lt; driving time ≤1 h at the baseline exhibited a significantly lower risk of incident dementia than the other groups. In addition, in the analysis of non-occupational computer use duration, the 0 h group exhibited a significantly higher risk than the other groups. Our results indicate that different sedentary behaviors have different associations with dementia risk over time and have no simple dose–response relationship with dementia risk. The sedentary behavior risk assessments must consider these factors.
RELN rs7341475 Associates with Brain Structure in Japanese Healthy Females. 国際誌

Ryo Yamaguchi, Izumi Matsudaira, Hikaru Takeuchi, Tadashi Imanishi, Ryosuke Kimura, Hiroaki Tomita, Ryuta Kawashima, Yasuyuki Taki

Neuroscience　494　38-50　2022年5月13日

DOI： 10.1016/j.neuroscience.2022.05.007 　

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Although temperament has been regarded as an innate aspect of human personality, its association with proteins involved in embryonic development is unclear. Reelin, encoded by RELN, plays an important role in brain development. Herein, we investigated the association between the RELN rs7341475 (G/A) single nucleotide polymorphism, detected as a female-specific risk factor for schizophrenia, brain structure, and temperament to elucidate the role of RELN in the development of human personality. In this study, 1580 healthy young Japanese adults were genotyped for RELN rs7341475 and completed the Temperament and Character Inventory. Whole-brain analysis of covariance was conducted to investigate differences between genotypes in regional gray matter volume (rGMV) and cortical morphology. Additionally, multiple regression analysis was performed to examine the association of four temperaments with rGMV. Those statistical analyses were performed separately for males and females. Individuals with G/G homozygosity showed significantly greater rGMV in several areas of the brain, particularly the bilateral cingulate and temporal gyrus, as well as a larger value of fractal dimension in the left lateral occipital cortex. Furthermore, of the four temperaments, the novelty seeking was significantly and positively associated with rGMV in the right superior temporal gyrus, partially overlapping with areas where differences between the rs7341475 genotypes were detected. The above findings were detected only in females, but not in males. This is the first study to demonstrate the contribution of RELN rs7341475 to differences in brain structure in Japanese females, which may indicate vulnerability to schizophrenia and variations in human personality.
Loneliness inside of the brain: evidence from a large dataset of resting-state fMRI in young adult. 国際誌

Denilson Brilliant T, Hikaru Takeuchi, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Sugiko Hanawa, Atsushi Sekiguchi, Shigeyuki Ikeda, Kohei Sakaki, Kelssy Hitomi Dos Santos Kawata, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

Scientific reports　12　(1)　7856-7856　2022年5月12日

DOI： 10.1038/s41598-022-11724-5 　

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Although loneliness itself is a natural emotion, prolonged loneliness is detrimental to human health. Despite its detrimental effect, few loneliness-related neuroimaging studies have been published and some have limitations on the sample size number. This study aims to find the difference in resting-state functional connectivity associated with loneliness within a big sample size via the seed-based approach. Functional connectivity analysis was performed on a large cohort of young adults (N = 1336) using the seed-based functional connectivity approach to address the concern from previous studies. The analysis yielded statistically significant positive correlations between loneliness and functional connectivities between the inferior frontal gyrus and supplementary motor area, precentral gyrus, and superior parietal lobule. Additionally, the analysis replicated a finding from a previous study, which is increased functional connectivities between the inferior frontal gyrus and supplementary motor area. In conclusion, greater loneliness is reflected by stronger functional connectivity of the visual attention brain area.
Somatosensory evoked magnetic fields caused by mechanical stimulation of the periodontal ligaments. 国際誌

Eriya Shimada, Hiroyasu Kanetaka, Hiroki Hihara, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato, Kaoru Igarashi

Heliyon　8　(5)　e09464　2022年5月

DOI： 10.1016/j.heliyon.2022.e09464 　

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The periodontal ligaments are very important sensory organ for our daily life such as perception of food size or hardness, determination of jaw position, and adjustment of masticatory strength. The sensory properties of the periodontal ligament, especially those of the maxillary and mandibular molars, have not yet been fully investigated. Somatosensory evoked magnetic fields (SEFs) can be measured and evaluated for latency and intensity to determine the sensory transmission characteristics of each body parts. However, previous reports on SEFs in the oral region have only reported differences in upper and lower gingival and lip sensations. In this study, the aim was to clarify these sensory characteristics by measuring SEFs during mechanical stimulation of the periodontal ligament in the maxillary and mandibular first molars. Somatosensory evoked magnetic fields were measured in the contralateral hemispheres of 33 healthy volunteers. Mechanical stimulation of the maxillary and mandibular right first molars, and the left wrist was performed with a specific handmade tool. The first peak latency for the mandibular first molars was 41.7 ± 5.70 ms (mean ± SD), significantly shorter than that for the maxillary first molars at 47.7 ± 7.36 ms. The peak intensity for the mandibular first molars was 13.9 ± 6.06 nAm, significantly larger than that for the maxillary first molars at 7.63 ± 3.55 nAm. The locations in the contralateral hemispheres showed no significant difference between the maxillary first molars and mandibular first molars. These locations were more anteroinferior and exterior than that of the wrist, as suggested by the brain homunculus. Neural signals from the mandibular periodontal ligaments pass faster and more intensely to the central nervous system than those from the maxillary periodontal ligaments, and may preferentially participate in adjustment of the occlusal force and the occlusal position.
Neural correlates of Japanese honorific agreement processing mediated by socio-pragmatic factors: An fMRI study

Haining Cui, Hyeonjeong Jeong, Kiyo Okamoto, Daiko Takahashi, Ryuta Kawashima, Motoaki Sugiura

Journal of Neurolinguistics　62　101041-101041　2022年5月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.jneuroling.2021.101041 　

ISSN：0911-6044
A psychiatric disorder risk polymorphism of <scp>ITIH3</scp> is associated with multiple neuroimaging phenotypes in young healthy adults

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono(Tanaka), Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Tadashi Imanishi, Ryuta Kawashima

Psychiatry and Clinical Neurosciences　2022年4月5日
出版者・発行元： Wiley
DOI： 10.1111/pcn.13347 　

ISSN：1323-1316

eISSN：1440-1819
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study

Tatsushi Mutoh, Keiko Kunitoki, Yasuko Tatewaki, Shuzo Yamamoto, Benjamin Thyreau, Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki

GeroScience　2022年4月5日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s11357-022-00553-z 　

ISSN：2509-2715

eISSN：2509-2723
Shame proneness is associated with individual differences in temporal pole white matter structure. 国際誌

Carlos Makoto Miyauchi, Hikaru Takeuchi, Yasuyuki Taki, Seishu Nakagawa, Sugiko Hanawa, Atsushi Sekiguchi, Rui Nouchi, Yuko Sassa, Ryuta Kawashima

Social neuroscience　17　(2)　117-126　2022年4月

DOI： 10.1080/17470919.2022.2039287 　

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Shame and guilt are distinct negative moral emotions, although they are usually regarded as overlapping affective experiences. Of these two emotions, shame is more closely related to concerns about other people's judgment, whereas guilt is more related to concerns about one's own judgment. Although some studies have tried to identify the psychological process underlying shame as opposed to guilt, there is no clear evidence of brain regions that are specifically relevant to the experience of shame rather than guilt and, more generally, self-blame. We therefore investigated associations between individual differences in shame- and guilt-proneness and the gray and white matter structures of the brain using magnetic resonance imaging and voxel-based morphometry while controlling for associations with guilt- or shame-proneness. To accomplish this goal, we enrolled 590 healthy, right-handed individuals (338 men and 252 women; age, 20.6 ± 1.8 years). We administered a questionnaire to assess shame proneness and guilt proneness. Based on our hypothesis, we found that high shame proneness was associated with decreased regional white matter density only in the right inferior temporal pole, whereas no significant region was associated with guilt. The function of this area may be important for the underlying processes differentiating shame from guilt.
An fMRI validation study of the word-monitoring task as a measure of implicit knowledge: Exploring the role of explicit and implicit aptitudes in behavioral and neural processing

Yuichi Suzuki, Hyeonjeong Jeong, Haining Cui, Kiyo Okamoto, Ryuta Kawashima, Motoaki Sugiura

Studies in Second Language Acquisition　1-28　2022年3月28日
出版者・発行元： Cambridge University Press (CUP)
DOI： 10.1017/s0272263122000043 　

ISSN：0272-2631

eISSN：1470-1545

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Abstract In this study, neural representation of adult second language (L2) speakers’ implicit grammatical knowledge was investigated. Advanced L2 speakers of Japanese living in Japan, as well as L1 Japanese speakers, performed a word-monitoring task (proposed as an implicit knowledge test) in the MRI scanner. Behavioral measures were obtained from aptitude tests for explicit (language analytic ability) and implicit (statistical learning ability) learning. Findings indicate that, although both L1 and L2 speakers recruited neural circuits associated with procedural memory during the word-monitoring task, different brain regions were activated: premotor cortex (L1 speakers) and left caudate (L2 speakers). The premotor cortex activation was weaker in L2 than L1 speakers but was positively correlated with the left caudate activation, suggesting that their grammatical knowledge, while less automatized, was still developing. Behavioral sensitivity to errors was predicted only by explicit language aptitude, which may play a key role in the automatization of grammatical knowledge.
Auditory Cognitive Training Improves Brain Plasticity in Healthy Older Adults: Evidence From a Randomized Controlled Trial. 国際誌査読有り

Natasha Y S Kawata, Rui Nouchi, Kentaro Oba, Yutaka Matsuzaki, Ryuta Kawashima

Frontiers in aging neuroscience　14　826672-826672　2022年3月

DOI： 10.3389/fnagi.2022.826672 　

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The number of older adults is increasing globally. Aging is associated with cognitive and sensory decline. Additionally, declined auditory performance and cognitive function affect the quality of life of older adults. Therefore, it is important to develop an intervention method to improve both auditory and cognitive performances. The current study aimed to investigate the beneficial effects of auditory and cognitive training on auditory ability and cognitive functions in healthy older adults. Fifty healthy older adults were randomly divided into four training groups-an auditory-cognitive training group (AC training; n = 13), an auditory training group (A training; n = 13), a cognitive training group (C training; n = 14), and an active control group (n = 12). During the training period, we reduced the sound intensity level in AC and A training groups and increase training task difficulty in AC, A, and C training groups based on participants' performance. Cognitive function measures [digit-cancelation test (D-CAT); logical memory (LM); digit span (DS)], auditory measures [pure-tone audiometry (PTA)], and magnetic resonance imaging (MRI) scans were performed before and after the training periods. We found three key findings. First, the AC training group showed difference between other training groups (A, C, and active control training groups) in regional gray matter volume (rGMV) in the right dorsolateral prefrontal cortex, the left inferior temporal gyrus (L. ITG), the left superior frontal gyrus, the left orbitofrontal cortex, the right cerebellum (lobule 7 Crus 1). Second, the auditory training factor groups (ATFGs, the AC and A training groups) improved auditory measures and increased the rGMV and functional connectivity (FC) in the left temporal pole compared to the non-ATFGs (the C training group and active control group). Third, the cognitive training factor groups (CTFGs; the AC and C training groups) showed statistically significant improvement in cognitive performances in LM and D-CAT compared to the non-CTFGs (the A training group and active control group). Therefore, the auditory training factor and cognitive training factor would be useful in enhancing the quality of life of older adults. The current AC training study, the plasticity of the brain structure was observed after 4 weeks of training.
Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in mice. 国際誌

Takeshi Hiramoto, Akira Sumiyoshi, Takahira Yamauchi, Kenji Tanigaki, Qian Shi, Gina Kang, Rie Ryoke, Hiroi Nonaka, Shingo Enomoto, Takeshi Izumi, Manzoor A Bhat, Ryuta Kawashima, Noboru Hiroi

Molecular psychiatry　27　(2)　929-938　2022年2月

DOI： 10.1038/s41380-021-01318-4 　

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Copy number variants (CNVs) have provided a reliable entry point to identify the structural correlates of atypical cognitive development. Hemizygous deletion of human chromosome 22q11.2 is associated with impaired cognitive function; however, the mechanisms by which the CNVs contribute to cognitive deficits via diverse structural alterations in the brain remain unclear. This study aimed to determine the cellular basis of the link between alterations in brain structure and cognitive functions in mice with a heterozygous deletion of Tbx1, one of the 22q11.2-encoded genes. Ex vivo whole-brain diffusion-tensor imaging (DTI)-magnetic resonance imaging (MRI) in Tbx1 heterozygous mice indicated that the fimbria was the only region with significant myelin alteration. Electron microscopic and histological analyses showed that Tbx1 heterozygous mice exhibited an apparent absence of large myelinated axons and thicker myelin in medium axons in the fimbria, resulting in an overall decrease in myelin. The fimbria of Tbx1 heterozygous mice showed reduced mRNA levels of Ng2, a gene required to produce oligodendrocyte precursor cells. Moreover, postnatal progenitor cells derived from the subventricular zone, a source of oligodendrocytes in the fimbria, produced fewer oligodendrocytes in vitro. Behavioral analyses of these mice showed selectively slower acquisition of spatial memory and cognitive flexibility with no effects on their accuracy or sensory or motor capacities. Our findings provide a genetic and cellular basis for the compromised cognitive speed in patients with 22q11.2 hemizygous deletion.
Application of Diffusion Tensor Imaging Fiber Tractography for Human Masseter Muscle.

Takehiko Sugano, Nobuhiro Yoda, Toru Ogawa, Teruo Hashimoto, Kenta Shobara, Kuniyasu Niizuma, Ryuta Kawashima, Keiichi Sasaki

The Tohoku journal of experimental medicine　256　(2)　151-160　2022年2月

DOI： 10.1620/tjem.256.151 　

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Diffusion tensor imaging (DTI) has been used to indicate the direction of nerve and muscle fibers by using the characteristics that water molecules preferentially diffuse along the fibrous structure. However, DTI fiber tractography for multipennate muscles, such as the masseter muscle, is challenging due to a lack of data regarding the imaging parameters. This study aimed to determine the optimal DTI parameters for masseter muscle fiber tractography. A 27-year-old healthy man voluntarily underwent DTI and T1-weighted magnetic resonance imaging of the right masseter muscle. Four imaging parameter settings were created by combining the following parameters that particularly affect the signal-to-noise ratio: b-value, number of excitations (NEX), and number of motion probing gradient (MPG) directions. DTI fiber tractography was performed using specific software for each parameter setting. The length and orientation of the muscle fibers in each layer were calculated. As a result, the masseter muscle fibers of each layer were identified on DTI. Although the detected fiber length was affected significantly by the imaging parameters, the fiber orientation was insignificantly affected. The appropriate combination of the b-value, NEX, and the number of MPG directions for masseter muscle fiber tractography could be determined based on previously reported anatomical data of the masseter muscle fibers. DTI may enable the non-invasive evaluation of masseter muscle fiber length and orientation. Elucidation of the details of masseter muscle fiber orientation is useful in evaluating stomatognathic biomechanics and muscle disorders.
Neural Correlates Predicting Lane-Keeping and Hazard Detection: An fMRI Study Featuring a Pedestrian-Rich Simulator Environment. 国際誌査読有り

Kentaro Oba, Koji Hamada, Azumi Tanabe-Ishibashi, Fumihiko Murase, Masaaki Hirose, Ryuta Kawashima, Motoaki Sugiura

Frontiers in human neuroscience　16　754379-754379　2022年2月

DOI： 10.3389/fnhum.2022.754379 　

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Distracted attention is considered responsible for most car accidents, and many functional magnetic resonance imaging (fMRI) researchers have addressed its neural correlates using a car-driving simulator. Previous studies, however, have not directly addressed safe driving performance and did not place pedestrians in the simulator environment. In this fMRI study, we simulated a pedestrian-rich environment to explore the neural correlates of three types of safe driving performance: accurate lane-keeping during driving (driving accuracy), the braking response to a preceding car, and the braking response to a crossing pedestrian. Activation of the bilateral frontoparietal control network predicted high driving accuracy. On the other hand, activation of the left posterior and right anterior superior temporal sulci preceding a sudden pedestrian crossing predicted a slow braking response. The results suggest the involvement of different cognitive processes in different components of driving safety: the facilitatory effect of maintained attention on driving accuracy and the distracting effect of social-cognitive processes on the braking response to pedestrians.
Effects of sulforaphane intake on processing speed and negative moods in healthy older adults: Evidence from a randomized controlled trial. 国際誌

Rui Nouchi, Qingqiang Hu, Yusuke Ushida, Hiroyuki Suganuma, Ryuta Kawashima

Frontiers in aging neuroscience　14　929628-929628　2022年

DOI： 10.3389/fnagi.2022.929628 　

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BACKGROUND: Recent studies have reported that sulforaphane (SFN) intake with cognitive training had positive effects on cognitive functions. However, it is still unknown whether SFN intake alone has beneficial effects on cognition as well as mood. We investigated whether a SFN intake intervention improved cognitive performance and mood states in healthy older adults. METHODS: In a 12-week, double-blinded, randomized controlled trial (RCT), we randomly assigned 144 older adults to a SFN group or a placebo group. We asked the participants to take a supplement (SFN or placebo) for 12 weeks. We measured several cognitive functions, mood states, and biomarkers before and after the intervention period. RESULTS: The SFN group showed improvement in processing speed and a decrease in negative mood compared to the placebo group. In addition, the SFN group exhibited a higher SFN-N-acetyl-L-cysteine (NAC) level compared to the placebo group. However, there were no significant results in other biomarkers of oxidant stress, inflammation, or neural plasticity. DISCUSSION: These results indicate that nutrition interventions using SFN can have positive effects on cognitive functioning and mood in healthy older adults.
Cognitive Training with Neurofeedback Using NIRS Improved Cognitive Functions in Young Adults: Evidence from a Randomized Controlled Trial. 国際誌

Rui Nouchi, Haruka Nouchi, Jerome Dinet, Ryuta Kawashima

Brain sciences　12　(1)　2021年12月21日

DOI： 10.3390/brainsci12010005 　

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(1) Background: A previous study has shown that cognitive training with neurofeedback (CT-NF) using down-regulation improves cognitive functions in young adults. Neurofeedback has two strategies for manipulating brain activity (down-regulation and upregulation). However, the benefit of CT-NF with the upregulation of cognitive functions is still unknown. In this study, we investigated whether the upregulation of CT-NF improves a wide range of cognitive functions compared to cognitive training alone. (2) Methods: In this double-blinded randomized control trial (RCT), 60 young adults were randomly assigned to one of three groups: CT-NF group, CT alone group, and an active control (ACT) group who played a puzzle game. Participants in the three groups used the same device (tablet PC and 2ch NIRS (near-infrared spectroscopy)) and performed the training game for 20 min every day for four weeks. We measured brain activity during training in all groups, but only CT-NFs received NF. We also measured a wide range of cognitive functions before and after the intervention period. (3) Results: The CT-NF groups showed superior beneficial effects on episodic memory, working memory, and attention compared to the CT alone and ACT groups. In addition, the CT-NF group showed an increase in brain activity during CT, which was associated with improvements in cognitive function. (4) Discussion: This study first demonstrated that the CT-NF using the upregulation strategy has beneficial effects on cognitive functions compared to the CT alone. Our results suggest that greater brain activities during CT would enhance a benefit from CT.
Diet and Dementia: A Prospective Study

Hikaru Takeuchi, Ryuta Kawashima

Nutrients　13　(12)　4500-4500　2021年12月16日
出版者・発行元： MDPI AG
DOI： 10.3390/nu13124500 　

eISSN：2072-6643

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Whether dietary and nutrition and dietary patterns are associated with the development of dementia is an interesting research question. Participants of a longitudinal cohort study that included European adults who were middle to old aged at baseline and who had not been diagnosed with dementia at baseline (2006–2010) and had not been diagnosed with dementia or died within 5 years after baseline were followed up (until 2018) and analyzed. Associations between intake frequency of each food class measured by the food-frequency questionnaire at baseline and incident dementia 5 years after baseline were analyzed after correcting for confounding variables. A total of approximately 340,000 participants and 900 cases were included in the analysis for each food class. Cox proportional hazard models with self-reported intake level of each food category divided into four mostly equally divided categorical variables revealed a high intake of bread, moderate total meat and total fish intake and low vegetable and fruit intake were thus associated with a small but significant decrease in the onset risk of dementia, while poultry and cereal were not. These findings are mostly inconsistent with the idea that Mediterranean diet is associated with lower risk of subsequent incident dementia.
聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

白倉真之, 川瀬哲明, 菅野彰剛, 太田淳, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学　49　(5)　440-440　2021年10月
出版者・発行元： (一社)日本臨床神経生理学会
ISSN：1345-7101

eISSN：2188-031X
聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

白倉真之, 川瀬哲明, 菅野彰剛, 太田淳, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学　49　(5)　440-440　2021年10月
出版者・発行元： (一社)日本臨床神経生理学会
ISSN：1345-7101

eISSN：2188-031X
Subjective hearing handicap is associated with processing speed and visuospatial performance in older adults without severe hearing handicap

Natasha Y.S. Kawata, Rui Nouchi, Toshiki Saito, Ryuta Kawashima

Experimental Gerontology　111614-111614　2021年10月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.exger.2021.111614 　

ISSN：0531-5565
Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex. 国際誌

Hikaru Takeuchi, Ryosuke Kimura, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Sugiko Hanawa, Kunio Iizuka, Atsushi Sekiguchi, Tsuyoshi Araki, Carlos Makoto Miyauchi, Shigeyuki Ikeda, Kohei Sakaki, Kelssy H Dos S Kawata, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Tadashi Imanishi, Ryuta Kawashima

Human brain mapping　42　(18)　6028-6037　2021年9月29日

DOI： 10.1002/hbm.25667 　

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It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD-PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole-brain voxel-by-voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD-PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD-PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD-PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals.
The influence of NRXN1 on systemizing and the brain structure in healthy adults

Yuka Shiota, Izumi Matsudaira, Hikaru Takeuchi, Chiaki Ono, Hiroaki Tomita, Ryuta Kawashima, Yasuyuki Taki

Brain Imaging and Behavior　16　(2)　692-701　2021年9月16日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s11682-021-00530-8 　

ISSN：1931-7557

eISSN：1931-7565
Magnetoencephalography to confirm epileptiform discharges mimicking small sharp spikes in temporal lobe epilepsy. 国際誌

Dai Agari, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Makoto Ishida, Ryuta Kawashima, Nobukazu Nakasato

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　132　(8)　1785-1789　2021年8月

DOI： 10.1016/j.clinph.2021.03.049 　

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OBJECTIVE: To determine whether magnetoencephalography (MEG) can identify epileptiform discharges mimicking small sharp spikes (SSSs) on scalp electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE). METHODS: We retrospectively reviewed simultaneous scalp EEG and MEG recordings of 83 consecutive patients with TLE and 49 with extra-TLE (ETLE). RESULTS: SSSs in scalp EEG were detected in 15 (18.1%) of 83 TLE patients compared to only two (4.1%) of 49 ETLE patients (p = 0.029). Five of the 15 TLE patients had MEG spikes with concurrent SSSs in EEG, but neither of the 2 ETLE patients. Three of these 5 TLE patients had additional interictal epileptiform discharges (IEDs) in EEG and MEG. Equivalent current dipoles (ECDs) of MEG spikes with concurrent SSSs and IEDs showed no difference in temporal lobe localization and horizontal orientation, whereas ECD moments were smaller in MEG spikes with concurrent SSSs than those with IEDs. CONCLUSIONS: SSSs were more common in TLE than in ETLE. At least some morphologically diagnosed SSSs are true but low-amplitude epileptiform discharges in TLE which can be identified with simultaneous MEG. SIGNIFICANCE: Simultaneous MEG is useful to identify epileptiform discharges mimicking SSSs in patients with TLE.
Lead exposure is associated with functional and microstructural changes in the healthy human brain. 国際誌

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susum Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Communications biology　4　(1)　912-912　2021年7月26日

DOI： 10.1038/s42003-021-02435-0 　

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Lead is a toxin known to harm many organs in the body, particularly the central nervous system, across an individual's lifespan. To date, no study has yet investigated the associations between body lead level and the microstructural properties of gray matter areas, and brain activity during attention-demanding tasks. Here, utilizing data of diffusion tensor imaging, functional magnetic resonance imaging and cognitive measures among 920 typically developing young adults, we show greater hair lead levels are weakly but significantly associated with (a) increased working memory-related activity in the right premotor and pre-supplemental motor areas, (b) lower fractional anisotropy (FA) in white matter areas near the internal capsule, (c) lower mean diffusivity (MD) in the dopaminergic system in the left hemisphere and other widespread contingent areas, and (d) greater MD in the white matter area adjacent to the right fusiform gyrus. Higher lead levels were also weakly but significantly associated with lower performance in tests of high-order cognitive functions, such as the psychometric intelligence test, greater impulsivity measures, and higher novelty seeking and extraversion. These findings reflect the weak effect of daily lead level on the excitability and microstructural properties of the brain, particularly in the dopaminergic system.
Benefits of VR Physical Exercise on Cognition in Older Adults with and without Mild Cognitive Decline: A Systematic Review of Randomized Controlled Trials

Kohei Sakaki, Rui Nouchi, Yutaka Matsuzaki, Toshiki Saito, Jérôme Dinet, Ryuta Kawashima

Healthcare　9　(7)　883-883　2021年7月13日
出版者・発行元： MDPI AG
DOI： 10.3390/healthcare9070883 　

eISSN：2227-9032

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It is well known that physical exercise has beneficial effects on cognitive function in older adults. Recently, several physical exercise programs with virtual reality (VR) have been proposed to support physical exercise benefits. However, it is still unclear whether VR physical exercise (VR-PE) has positive effects on cognitive function in older adults. The purpose of this study was to conduct a systematic review (SR) of the effects of VR-PE on cognitive function in older adults with and without cognitive decline. We used academic databases to search for research papers. The criteria were intervention study using any VR-PE, participants were older adults with and without mild cognitive decline (not dementia), and cognitive functions were assessed. We found that 6 of 11 eligible studies reported the significant benefits of the VR-PE on a wide range of cognitive functions in aging populations. The SR revealed that VR-PE has beneficial effects on the inhibition of executive functions in older adults with and without mild cognitive decline. Moreover, VR-PE selectively leads to improvements in shifting and general cognitive performance in healthy older adults. The SR suggests that VR-PE could be a successful approach to improve cognitive function in older adults with and without cognitive decline.
Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchid, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Ryuta Kawashima

Journal of Psychosomatic Research　149　110590-110590　2021年7月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.jpsychores.2021.110590 　

ISSN：0022-3999
Neural Evidence of Language Membership Control in Bilingual Word Recognition: An fMRI Study of Cognate Processing in Chinese–Japanese Bilinguals

Ming-Che Hsieh, Hyeonjeong Jeong, Motoaki Sugiura, Ryuta Kawashima

Frontiers in Psychology　12　2021年6月7日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fpsyg.2021.643211 　

eISSN：1664-1078

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This study aims to examine the neural mechanisms of resolving response competition during bilingual word recognition in the context of language intermixing. During fMRI scanning, Chinese–Japanese unbalanced bilinguals were required to perform a second-language (L2) lexical decision task composed of cognates, interlingual homographs, matched control words from both Chinese (first language) and Japanese (L2), and pseudowords. Cognate word processing showed longer reaction times and greater activation in the supplementary motor area (SMA) than L2 control word processing. In light of the orthographic and semantic overlap of cognates, these results reflect the cognitive processing involved in resolving response conflicts enhanced by the language membership of non-target language during bilingual word recognition. A significant effect of L2 proficiency was also observed only in the SMA, which is associated with the task decision system. This finding supports the bottom-up process in the BIA+ model and the Multilink model. The task/decision system receives the information from the word identification system, making appropriate responses during bilingual word recognition.
Prefrontal Inter-brain Synchronization Reflects Convergence and Divergence of Flow Dynamics in Collaborative Learning: A Pilot Study

Takayuki Nozawa, Mutsumi Kondo, Reiko Yamamoto, Hyeonjeong Jeong, Shigeyuki Ikeda, Kohei Sakaki, Yoshihiro Miyake, Yasushige Ishikawa, Ryuta Kawashima

Frontiers in Neuroergonomics　2　2021年6月3日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fnrgo.2021.686596 　

eISSN：2673-6195

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Flow is a highly motivated and affectively positive state in which a person is deeply engaged in an activity and feeling enjoyment from it. In collaborative activities, it would be optimal if all participants were in a state of flow. However, flow states fluctuate amongst individuals due to differences in the dynamics of motivation and cognition. To explore the possibility that inter-brain synchronization can provide a quantitative measure of the convergence and divergence of collective motivational dynamics, we conducted a pilot study to investigate the relationship between inter-brain synchronization and the interpersonal similarity of flow state dynamics during the collaborative learning process. In two English as a Foreign Language (EFL) classes, students were divided into groups of three-four and seated at desks facing each other while conducting a 60-min group work. In both classes, two groups with four members were randomly selected, and their medial prefrontal neural activities were measured simultaneously using wireless functional near-infrared spectroscopy (fNIRS) devices. Later the participants observed their own activities on recorded videos and retrospectively rated their subjective degree of flow state on a seven-point scale for each 2-min period. For the pairs of students whose neural activities were measured, the similarity of their flow experience dynamics was evaluated by the temporal correlation between their flow ratings. Prefrontal inter-brain synchronization of the same student pairs during group work was evaluated using wavelet transform coherence. Statistical analyses revealed that: (1) flow dynamics were significantly more similar for the student pairs within the same group compared to the pairs of students assigned across different groups; (2) prefrontal inter-brain synchronization in the relatively short time scale (9.3–13.9 s) was significantly higher for the within-group pairs than for the cross-group pairs; and (3) the prefrontal inter-brain synchronization at the same short time scale was significantly and positively correlated with the similarity of flow dynamics, even after controlling for the effects of within- vs. cross-group pair types from the two variables. These suggest that inter-brain synchronization can indeed provide a quantitative measure for converging and diverging collective motivational dynamics during collaborative learning, with higher inter-brain synchronization corresponding to a more convergent flow experience.
Brain Microstructural Properties Related to Subjective Well-Being: Diffusion Tensor Imaging Analysis. 国際誌

Chiaki Terao Maeda, Hikaru Takeuchi, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Ikeda Shigeyuki, Susumu Yokota, Daniele Magistro, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

Social cognitive and affective neuroscience　16　(10)　1079-1090　2021年5月14日

DOI： 10.1093/scan/nsab063 　

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Although it is known that health is not merely the absence of disease, the positive aspects of mental health have been less comprehensively researched compared with its negative aspects. Subjective well-being is one of the indicators of positive psychology, and high subjective well-being is considered to benefit individuals in multiple ways. However, the neural mechanisms underlying individual differences in subjective well-being remain unclear, particularly in terms of brain microstructural properties as detected by diffusion tensor imaging. The present study aimed to investigate the relationship between measurements of diffusion tensor imaging (mean diffusivity and fractional anisotropy) and the degree of subjective well-being as measured using a questionnaire. Voxel-based analysis was used to investigate the association between mean diffusivity and subjective well-being scores in healthy young adults (age, 20.7 ± 1.8 years; 695 males and 514 females). Higher levels of subjective well-being were found to be associated with lower mean diffusivity in areas surrounding the right putamen, insula, globus pallidus, thalamus, and caudate. These results indicated that individual subjective well-being is associated with variability in brain microstructural properties.
Childhood socioeconomic status is associated with psychometric intelligence and microstructural brain development. 国際誌

Hikaru Takeuchi, Yasuyuki Taki, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

Communications biology　4　(1)　470-470　2021年4月29日

DOI： 10.1038/s42003-021-01974-w 　

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Childhood socioeconomic status is robustly associated with various children's cognitive factors and neural mechanisms. Here we show the association of childhood socioeconomic status with psychometric intelligence and mean diffusivity and fractional anisotropy using diffusion tensor imaging at the baseline experiment (N = 285) and longitudinal changes in these metrics after 3.0 ± 0.3 years (N = 223) in a large sample of normal Japanese children (mean age = 11.2 ± 3.1 years). After correcting for confounding factors, cross-sectional and longitudinal analyses show that higher childhood socioeconomic status is associated with greater baseline and baseline to follow-up increase of psychometric intelligence and mean diffusivity in areas around the bilateral fusiform gyrus. These results demonstrate that higher socioeconomic status is associated with higher psychometric intelligence measures and altered microstructural properties in the fusiform gyrus which plays a key role in reading and letter recognition and further augmentation of such tendencies during development. Definitive conclusions regarding the causality of these relationships requires intervention and physiological studies. However, the current findings should be considered when developing and revising policies regarding education.
Ventral–Dorsal Subregions in the Posterior Cingulate Cortex Represent Pay and Interest, Two Key Attributes of Job Value

Shunsui Matsuura, Shinsuke Suzuki, Kosuke Motoki, Shohei Yamazaki, Ryuta Kawashima, Motoaki Sugiura

Cerebral Cortex Communications　2　(2)　2021年4月1日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/texcom/tgab018 　

eISSN：2632-7376

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<title>Abstract</title> Career choices affect not only our financial status but also our future well-being. When making these choices, individuals evaluate their willingness to obtain a job (i.e., job values), primarily driven by simulation of future pay and interest. Despite the importance of these decisions, their underlying neural mechanisms remain unclear. In this study, we examined the neural representation of pay and interest. Forty students were presented with 80 job names and asked to evaluate their job values while undergoing functional magnetic resonance imaging (fMRI). Following fMRI, participants rated the jobs in terms of pay and interest. The fMRI data revealed that the ventromedial prefrontal cortex (vmPFC) was associated with job value representation, and the ventral and dorsal regions of the posterior cingulate cortex (PCC) were associated with pay and interest representations, respectively. These findings suggest that the neural computations underlying job valuation conform to a multi-attribute decision-making framework, with overall value signals represented in the vmPFC and the attribute values (i.e., pay and interest) represented in specific regions outside the vmPFC, in the PCC. Furthermore, anatomically distinct representations of pay and interest in the PCC may reflect the differing roles of the two subregions in future simulations.
Intrinsic hippocampal functional connectivity underlying rigid memory in children and adolescents with autism spectrum disorder: A case-control study. 国際誌

Teruo Hashimoto, Susumu Yokota, Yutaka Matsuzaki, Ryuta Kawashima

Autism : the international journal of research and practice　13623613211004058-13623613211004058　2021年3月28日

DOI： 10.1177/13623613211004058 　

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LAY ABSTRACT: Atypical learning and memory in early life can promote atypical behaviors in later life. Specifically, less relational learning and inflexible retrieval in childhood may enhance restricted and repeated behaviors in patients with autism spectrum disorder. The purpose of this study was to elucidate the mechanisms of atypical memory in children with autism spectrum disorder. We conducted picture-name pair learning and delayed-recognition tests with two groups of youths: one group with high-functioning autism spectrum disorder children (aged 7-16, n = 41) and one group with typically developing children (n = 82) that matched the first group's age, sex, and full-scale IQ. We examined correlations between successful recognition scores and neural connectivity during resting in the magnetic resonance imaging scanner without thinking about anything. Although both learning and retrieval performances were comparable between the two groups, we observed significantly fewer memory gains in the autism spectrum disorder group than in the typically developing group. The memory network was involved in successful memory retrieval in youths with typically developing, while the other memory systems that do not depend to a great degree on networks may be involved in successful memory in youths with autism spectrum disorder. Context-independent and less relational memory processing may be associated with fewer memory gains in autism spectrum disorder. In other words, autism spectrum disorder youths might benefit from non-relational memory. These atypical memory characteristics in autism spectrum disorder may exaggerate their inflexible behaviors in some situations, or-vice versa-their atypical behaviors may result in rigid and less connected memories.
Association Between OLIG2 Gene SNP rs1059004 and Negative Self-Schema Constructing Trait Factors Underlying Susceptibility to Depression

Hiroshi Komatsu, Hikaru Takeuchi, Chiaki Ono, Zhiqian Yu, Yoshie Kikuchi, Yoshihisa Kakuto, Shunichi Funakoshi, Takashi Ono, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

Frontiers in Psychiatry　12　2021年3月8日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fpsyt.2021.631475 　

eISSN：1664-0640

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Recent evidence has indicated that the disruption of oligodendrocytes may be involved in the pathogenesis of depression. Genetic factors are likely to affect trait factors, such as characteristics, rather than state factors, such as depressive symptoms. Previously, a negative self-schema had been proposed as the major characteristic of constructing trait factors underlying susceptibility to depression. Thus, the association between a negative self-schema and the functional single nucleotide polymorphism (SNP) rs1059004 in the <italic>OLIG2</italic> gene, which influences <italic>OLIG2</italic> gene expression, white matter integrity, and cerebral blood flow, was evaluated. A total of 546 healthy subjects were subjected to genotype and psychological evaluation using the Beck Depression Inventory-II (BDI-II) and the Brief Core Schema Scale (BCSS). The rs1059004 SNP was found to be associated with the self-schema subscales of the BCSS and scores on the BDI-II in an allele dose-dependent manner, and to have a predictive impact on depressive symptoms via a negative-self schema. The results suggest the involvement of a genetic factor regulating oligodendrocyte function in generating a negative-self schema as a trait factor underlying susceptibility to depression.
General Intelligence Is Associated with Working Memory-Related Functional Connectivity Change: Evidence from a Large-Sample Study

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

Brain Connectivity　11　(2)　89-102　2021年3月

DOI： 10.1089/brain.2020.0769 　

ISSN：2158-0014

eISSN：2158-0022
Brain Structures and Activity During a Working Memory Task Associated with Internet Addiction Tendency in Young Adults

Saeid Sadeghi, Hikaru Takeuchi, Bita Shalani, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

2021年2月4日
出版者・発行元： Research Square
DOI： 10.21203/rs.3.rs-153035/v1 　

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<title>Abstract</title> An increasing number of young people use internet excessively over the last decades, which leads to adverse impacts on individuals and society. The structural and functional brain characteristics associated with the excessive use of the internet have attracted substantial research attention in the past decade; however, due to the small sample sizes of past studies, many findings are inconsistent. Also, the relationship between internet addiction tendency (IAT) and regional brain activity during working memory (WM), a critical cognitive function governing learned behavior, has not been explored. In current study, we used voxel-based morphometry (VBM) and multiple regression analysis to assess the relationship between IAT score and regional gray and white matter volumes (rGMVs and rWMVs) and brain activity during a WM task in a large sample of healthy young adults (n= 1,154, mean age, 20.71 ± 1.78 years).We found a significant positive correlation between IAT score and GMV of right supramarginal gyrus (rSMG) and significant negative correlations with WMVs of right temporal lobe (sub-gyral and superior temporal gyrus), right sublobar area (extra-nuclear and lentiform nucleus), right cerebellar anterior lobe, cerebellar tonsil, right frontal lobe (inferior frontal gyrus and sub-gyral areas), and the pons. Also, IAT was significantly and positively correlated with brain activity in the default-mode network (DMN), medial frontal gyrus, medial part of the superior frontal gyrus, and anterior cingulate cortex) during a 2-back WM task. Moreover, whole-brain analyses of rGMV showed significant effects of interaction between sex and the IAT scores in the area spreading around the left anterior insula and left lentiform. This interaction was moderated by positive correlation in females.These results indicate that IAT is associated with (a) increased GMV in rSMG, which is involved in phonological processing, (b) decreased WMVs in areas of frontal, sublobar, and temporal lobes, which are involved in response inhibition, and (c) reduced task-induced deactivation of the DMN, indicative of altered attentional allocation.
Brain Training and Sulforaphane Intake Interventions Separately Improve Cognitive Performance in Healthy Older Adults, Whereas a Combination of These Interventions Does Not Have More Beneficial Effects: Evidence from a Randomized Controlled Trial

Rui Nouchi, Qingqiang Hu, Toshiki Saito, Natasha Yuriko dos Santos Kawata, Haruka Nouchi, Ryuta Kawashima

Nutrients　13　(2)　352-352　2021年1月25日
出版者・発行元： MDPI AG
DOI： 10.3390/nu13020352 　

eISSN：2072-6643

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Background: Earlier studies have demonstrated that a single-domain intervention, such as a brain-training (BT) game alone and a sulforaphane (SFN) intake, positively affects cognition. This study examined whether a combined BT and SFN intake intervention has beneficial effects on cognitive function in older adults. Methods: In a 12-week double-blinded randomized control trial, 144 older adults were randomly assigned to one of four groups: BT with SFN (BT-S), BT with placebo (BT-P), active control game (AT) with SFN (AT-S), and active control game with placebo (AT-P). We used Brain Age in BT and Tetris in AT. Participants were asked to play BT or AT for 15 min a day for 12 weeks while taking a supplement (SFN or placebo). We measured several cognitive functions before and after the intervention period. Results: The BT (BT-S and BT-P) groups showed more improvement in processing speed than the active control groups (AT-S and AT-P). The SFN intake (BT-S and AT-S) groups recorded significant improvements in processing speed and working memory performance unlike the placebo intake groups (BT-P and AT-P). However, we did not find any evidence of the combined intervention’s beneficial effects on cognition. Discussion: We discussed a mechanism to improve cognitive functions in the BT and SFN alone interventions.
N100m latency shortening caused by selective attention. 国際誌

Yuri Nomura, Tetsuaki Kawase, Akitake Kanno, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

Brain research　1751　147177-147177　2021年1月15日

DOI： 10.1016/j.brainres.2020.147177 　

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The N100m response to a specific same-sound stimulus may be altered by the degree of attention paid to the stimulus. When participants selectively pay attention to the stimulus, the N100m amplitude increases; however, minimal effects are observed on the N100m latency. In this study, we examined the effects of selective special attention (motivation) to extract the frequency (or pitch) information from a probe tone on the N100m response to the probe tone. We compared the N100m latencies and amplitudes using magnetoencephalography, with the following three experimental conditions: 1) vocalization task protocol (vocalize in tune with the pitch of the probe tone after the presentation of the probe tone), 2) hearing task protocol (just listen to the probe tone), and 3) imagining (just imagine the vocalization in tune with the probe tone). The results indicated that the N100m latency in response to the probe tone was significantly shortened in the vocalization and imagining tasks compared with the hearing task in the right hemisphere of the brain. The amplitude was significantly increased in the vocalization task compared with the imagining and hearing tasks in the right hemisphere, and in the vocalization task compared with the hearing task in the left hemisphere of the brain; that is, the attention and/or motivation required to extract the information from the stimulus tones may have caused N100m latency shortening. To our knowledge, this study is the first to demonstrate that the N100m latency may be shortened under particular attentional conditions in response to a simple tone.
Different contra-sound effects between noise and music stimuli seen in N1m and psychophysical responses. 国際誌

Masayuki Shirakura, Tetsuaki Kawase, Akitake Kanno, Jun Ohta, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

PloS one　16　(12)　e0261637　2021年

DOI： 10.1371/journal.pone.0261637 　

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Auditory-evoked responses can be affected by the sound presented to the contralateral ear. The different contra-sound effects between noise and music stimuli on N1m responses of auditory-evoked fields and those on psychophysical response were examined in 12 and 15 subjects, respectively. In the magnetoencephalographic study, the stimulus to elicit the N1m response was a tone burst of 500 ms duration at a frequency of 250 Hz, presented at a level of 70 dB, and white noise filtered with high-pass filter at 2000 Hz and music stimuli filtered with high-pass filter at 2000 Hz were used as contralateral noise. The contralateral stimuli (noise or music) were presented in 10 dB steps from 80 dB to 30 dB. Subjects were instructed to focus their attention to the left ear and to press the response button each time they heard burst stimuli presented to the left ear. In the psychophysical study, the effects of contralateral sound presentation on the response time for detection of the probe sound of a 250 Hz tone burst presented at a level of 70 dB were examined for the same contra-noise and contra-music used in the magnetoencephalographic study. The amplitude reduction and latency delay of N1m caused by contra-music stimuli were significantly larger than those by contra-noise stimuli in bilateral hemisphere, even for low level of contra-music near the psychophysical threshold. Moreover, this larger suppressive effect induced by contra-music effects was also observed psychophysically; i.e., the change in response time for detection of the probe sound was significantly longer by adding contralateral music stimuli than by adding contra-noise stimuli. Regarding differences in effect between contra-music and contra-noise, differences in the degree of saliency may be responsible for their different abilities to disturb auditory attention to the probe sound, but further investigation is required to confirm this hypothesis.
Brain Activation during Thoughts of One’s Own Death and Its Linear and Curvilinear Correlations with Fear of Death in Elderly Individuals: An fMRI Study

Kanan Hirano, Kentaro Oba, Toshiki Saito, Shohei Yamazaki, Ryuta Kawashima, Motoaki Sugiura

Cerebral Cortex Communications　2　(1)　2021年1月1日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/texcom/tgab003 　

eISSN：2632-7376

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<title>Abstract</title> Facing one’s own death and managing the fear of death are important existential issues, particularly in older populations. Although recent functional magnetic resonance imaging (fMRI) studies have investigated brain responses to death-related stimuli, none has examined whether this brain activation was specific to one’s own death or how it was related to dispositional fear of death. In this study, during fMRI, 34 elderly participants (aged, 60–72 years) were presented with either death-related or death-unrelated negative words and asked to evaluate the relevance of these words to the “self” or the “other.” The results showed that only the left supplementary motor area (SMA) was selectively activated during self-relevant judgments of death-related words. Regression analyses of the effect of fear of death on brain activation during death-related thoughts identified a significant negative linear correlation in the right supramarginal gyrus (SMG) and an inverted-U-shaped correlation in the posterior cingulate cortex (PCC) only during self-relevant judgments. Our results suggest potential involvement of the SMA in the existential aspect of thoughts of death. The distinct fear-of-death-dependent responses in the SMG and PCC may reflect fear-associated distancing of the physical self and the processing of death-related thoughts as a self-relevant future agenda, respectively.
Brain activity predicts future learning success in intensive second language listening training

Mayumi Kajiura, Hyeonjeong Jeong, Natasha Y.S. Kawata, Shaoyun Yu, Toru Kinoshita, Ryuta Kawashima, Motoaki Sugiura

Brain and Language　212　104839-104839　2021年1月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.bandl.2020.104839 　

ISSN：0093-934X
Neural mechanisms of language learning from social contexts

Hyeonjeong Jeong, Ping Li, Wataru Suzuki, Motoaki Sugiura, Ryuta Kawashima

Brain and Language　212　104874-104874　2021年1月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.bandl.2020.104874 　

ISSN：0093-934X
Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity. 国際誌

Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Kunio Iizuka, Yuji Takano, Yoshihisa Kakuto, Shunichi Funakoshi, Takashi Ono, Junko Ito, Yasuto Kunii, Mizuki Hino, Atsuko Nagaoka, Yasushi Iwasaki, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Hirotsugu Azechi, Noriko Kudo, Ryota Hashimoto, Hirooki Yabe, Mari Yoshida, Yuko Saito, Akiyoshi Kakita, Nobuo Fuse, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

Schizophrenia bulletin　46　(6)　1619-1628　2020年12月1日

DOI： 10.1093/schbul/sbaa049 　

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Previous studies have indicated associations between several OLIG2 gene single-nucleotide polymorphisms (SNPs) and susceptibility to schizophrenia among Caucasians. Consistent with these findings, postmortem brain and diffusion tensor imaging studies have indicated that the schizophrenia-risk-associated allele (A) in the OLIG2 SNP rs1059004 predicts lower OLIG2 gene expression in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia patients and reduced white matter (WM) integrity of the corona radiata in normal brains among Caucasians. In an effort to replicate the association between this variant and WM integrity among healthy Japanese, we found that the number of A alleles was positively correlated with WM integrity in some fiber tracts, including the right posterior limb of the internal capsule, and with mean blood flow in a widespread area, including the inferior frontal operculum, orbital area, and triangular gyrus. Because the A allele affected WM integrity in opposite directions in Japanese and Caucasians, we investigated a possible association between the OLIG2 gene SNPs and the expression level of OLIG2 transcripts in postmortem DLPFCs. We evaluated rs1059004 and additional SNPs in the 5' upstream and 3' downstream regions of rs1059004 to cover the broader region of the OLIG2 gene. The 2 SNPs (rs1059004 and rs9653711) had opposite effects on OLIG2 gene expression in the DLPFC in Japanese and Caucasians. These findings suggest ethnicity-dependent opposite effects of OLIG2 gene SNPs on WM integrity and OLIG2 gene expression in the brain, which may partially explain the failures in replicating associations between genetic variants and psychiatric phenotypes among ethnicities.
Awake state-specific suppression of primary somatosensory evoked response correlated with duration of temporal lobe epilepsy

Makoto Ishida, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato

Scientific Reports　10　(1)　2020年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41598-020-73051-x 　

eISSN：2045-2322

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<title>Abstract</title> Epilepsy is a network disease. The primary somatosensory cortex (S1) is usually considered to be intact, but could be subclinically disturbed based on abnormal functional connectivity in patients with temporal lobe epilepsy (TLE). We aimed to investigate if the S1 of TLE is abnormally modulated. Somatosensory evoked magnetic fields (SEFs) evoked by median nerve stimulation were recorded in each hemisphere of 15 TLE patients and 28 normal subjects. All responses were separately averaged in the awake state and light sleep using background magnetoencephalography. Latency and strength of the equivalent current dipole (ECD) was compared between the groups for the first (M1) and second peaks. Latencies showed no significant differences between the groups in either wakefulness or light sleep. ECD strengths were significantly lower in TLE patients than in controls only during wakefulness. The reduction of M1 ECD strength in the awake state is significantly correlated with duration of epilepsy. SEFs of TLE patients showed pure ECD strength reduction without latency delay. The phenomenon occurred exclusively during wakefulness, suggesting that a wakefulness-specific modulator of S1 is abnormal in TLE. Repetitive seizures may gradually insult the modulator of S1 distant from the epileptogenic network.
The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity 査読有り

Hikarua Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Seishu Nakagawa, Kunio Iizuka, Kohei Sakaki, Tsuyoshi Araki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Sugiko Hanawa, Daniele Magistro, Yuka Kotozaki, Yukako Sasaki, Kelssy H. dos S. Kawata, Ryuta Kawashima

Scientific Reports　10　(1)　2020年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41598-020-69438-5 　

eISSN：2045-2322

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Abstract Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI < 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.
Virtual training leads to physical, cognitive and neural benefits in healthy adults 査読有り

Dalila Burin, Yingxu Liu, Noriki Yamaya, Ryuta Kawashima

NeuroImage　222　117297-117297　2020年11月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.neuroimage.2020.117297 　

ISSN：1053-8119
Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

Hikaru Takeuchi, Hiroaki Tomita, Ryan Browne, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Cerebral Cortex　31　(1)　672-680　2020年9月21日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/cercor/bhaa251 　

ISSN：1047-3211

eISSN：1460-2199

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<title>Abstract</title> The APOE ɛ4 allele is associated with a risk of Alzheimer’s disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex–genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex–genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.
Dorsolateral Prefrontal Cortex Activity during a Brain Training Game Predicts Cognitive Improvements after Four Weeks’ Brain Training Game Intervention: Evidence from a Randomized Controlled Trial

Rui Nouchi, Natasha Yuriko dos Santos Kawata, Toshiki Saito, Robin Maximilian Himmelmeier, Ryo Nakamura, Haruka Nouchi, Ryuta Kawashima

Brain Sciences　10　(8)　560-560　2020年8月15日
出版者・発行元： MDPI AG
DOI： 10.3390/brainsci10080560 　

eISSN：2076-3425

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Background: Recent studies have demonstrated that brain activities using NIRS (near-infrared spectroscopy) at baseline during cognitive tasks (e.g., N-back task) can predict the cognitive benefits of a cognitive training. In this study, we investigated whether brain activities during brain training game (BT) at baseline would predict benefits to cognitive functions after the intervention period. Methods: In a four-week double-blinded randomized control trial (RCT) 72 young adults were randomly assigned to one of the two groups: participants in the BT group played specific game, called the Brain Age. Participants in an active control group (ACT) played the puzzle game Tetris. We measured brain activity during the training games using two channel NIRS before the intervention period. Cognitive functions were tested before and after the four-week intervention period. Results: The BT showed significant improvements in inhibition, processing speed, and working memory performance compared to ACT. The left and right DLPFC (dorsolateral prefrontal cortex) brain activities during the BT at baseline were associated with improvements in inhibition and processing speed. Discussion: This randomized control trial first provides scientific evidence that DLPFC activities during BT at baseline can predict cognitive improvements after a four-week intervention period.
Differential roles of amygdala and posterior superior temporal sulcus in social scene understanding 査読有り

Kentaro Oba, Motoaki Sugiura, Sugiko Hanawa, Mizue Suzuki, Hyeonjeong Jeong, Yuka Kotozaki, Yukako Sasaki, Tatsuo Kikuchi, Takayuki Nozawa, Seishu Nakagawa, Ryuta Kawashima

Social Neuroscience　1-14　2020年7月21日
出版者・発行元： Informa UK Limited
DOI： 10.1080/17470919.2020.1793811 　

ISSN：1747-0919

eISSN：1747-0927
Neural mechanisms underlying concurrent listening of simultaneous speech. 国際誌査読有り

Natasha Yuriko Santos Kawata, Teruo Hashimoto, Ryuta Kawashima

Brain research　1738　146821-146821　2020年7月1日

DOI： 10.1016/j.brainres.2020.146821 　

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Can we identify what two people are saying at the same time? Although it is difficult to perfectly repeat two or more simultaneous messages, listeners can report information from both speakers. In a concurrent/divided listening task, enhanced attention and segregation of speech can be required rather than selection and suppression. However, the neural mechanisms of concurrent listening to multi-speaker concurrent speech has yet to be clarified. The present study utilized functional magnetic resonance imaging to examine the neural responses of healthy young adults listening to concurrent male and female speakers in an attempt to reveal the mechanism of concurrent listening. After practice and multiple trials testing concurrent listening, 31 participants achieved performance comparable with that of selective listening. Furthermore, compared to selective listening, concurrent listening induced greater activation in the anterior cingulate cortex, bilateral anterior insula, frontoparietal regions, and the periaqueductal gray region. In addition to the salience network for multi-speaker listening, attentional modulation and enhanced segregation of these signals could be used to achieve successful concurrent listening. These results indicate the presence of a potential mechanism by which one can listen to two voices with enhanced attention to saliency signals.
Association between resting-state functional connectivity and reading in two writing systems in Japanese children with and without developmental dyslexia 査読有り

Teruo Hashimoto, Hiroki Higuchi, Akira Uno, Susumu Yokota, Kohei Asano, Yasuyuki Taki, Ryuta Kawashima

Brain Connectivity　2020年6月21日
出版者・発行元： Mary Ann Liebert Inc
DOI： 10.1089/brain.2020.0759 　

ISSN：2158-0014

eISSN：2158-0022
A combination of self-reported data and social-related neural measures forecasts viral marketing success on social media 査読有り

Kosuke Motoki, Shinsuke Suzuki, Ryuta Kawashima, Motoaki Sugiura

Journal of Interactive Marketing　in press　2020年6月
Effects of simultaneously performed dual-task training with aerobic exercise and working memory training on cognitive functions and neural systems in the elderly 査読有り

Takeuchi H, Magistro D, Kotozaki Y, Motoki K, Kashkouli Nejad K, Nouchi R, Jeong H, Sato C, Salvatore S, Nagatomia R, Zecca M, Takanishi A, Kawashima R

Neural Plasticity　in press　2020年5月
Neural correlates of cognitive bias modification for interpretation. 国際誌査読有り

Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Ryuta Kawashima

Social cognitive and affective neuroscience　2020年4月23日

DOI： 10.1093/scan/nsaa026 　

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The effectiveness of cognitive bias modification for interpretation (CBM-I), a treatment method employed to reduce social anxiety (SA), has been examined. However, the neural correlates of CBM-I remain unclear, and we aimed to elucidate brain activities during intervention and activity changes associated with CBM-I effectiveness in a pre-post intervention comparison. Healthy participants divided into two groups (CBM, control) were scanned before, during and after intervention using functional magnetic resonance imaging. Ambiguous social situations followed by positive outcomes were repeatedly imagined by the CBM group during intervention, while half of the outcomes in the control group were negative. Whole-brain analysis revealed that activation of the somatomotor and somatosensory areas, occipital lobe, fusiform gyrus and thalamus during intervention was significantly greater in the CBM than in the control group. Furthermore, altered activities in the somatomotor and somatosensory areas, occipital lobe and posterior cingulate gyrus during interpreting ambiguous social situations showed a significant group × change in SA interaction. Our result suggests that when facing ambiguous social situations, positive imagery instilled by CBM-I is recalled, and interpretations are modified to contain social reward. These findings may help to suggest an alternative manner of enhancing CBM-I effectiveness from a cognitive-neuroscience perspective.
Increased grey matter volume of the right superior temporal gyrus in healthy children with autistic cognitive style: A VBM study

Akiko Kobayashi, Susumu Yokota, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

BRAIN AND COGNITION　139　2020年3月

DOI： 10.1016/j.bandc.2019.105514 　

ISSN：0278-2626

eISSN：1090-2147
近視を有する緑内障患者の3D T2強調MRIによる眼球形状と体積の定量的解析

面高宗子, 舘脇康子, 檜森紀子, 津田聡, 武藤達士, ティロー・バンジャマン, 松平泉, 川島隆太, 瀧靖之, 中澤徹

日本眼科学会雑誌　124　(臨増)　172-172　2020年3月
出版者・発行元： (公財)日本眼科学会
ISSN：0029-0203
Association of iron levels in hair with brain structures and functions in young adults. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)　58　126436-126436　2020年3月

DOI： 10.1016/j.jtemb.2019.126436 　

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BACKGROUND: Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects. METHODS: Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults. RESULTS: Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe. CONCLUSION: These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.
Effects of Lutein and Astaxanthin Intake on the Improvement of Cognitive Functions among Healthy Adults: A Systematic Review of Randomized Controlled Trials. 国際誌

Rui Nouchi, Takahiko Suiko, Eriko Kimura, Hiroki Takenaka, Michiaki Murakoshi, Akira Uchiyama, Megumi Aono, Ryuta Kawashima

Nutrients　12　(3)　2020年2月27日

DOI： 10.3390/nu12030617 　

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BACKGROUND: Fruits and vegetables are generally rich in antioxidants such as carotenoids. Consumption of carotenoids is expected to have benefits on cognitive functions in humans. However, previous randomized controlled trials (RCT) using carotenoids have reported inconsistent results. Therefore, this systematic review (SR) aimed to summarize the effect of carotenoid intake on cognitive functions in humans. METHOD: PubMed, Cochrane Library, Web of Science, and PsychoINFO were searched for research papers on carotenoid intake with the criteria that 1) oral carotenoid intake was evaluated using RCTs, 2) participants were healthy young, middle-aged, or older, and 3) cognitive functions were measured using RCTs. RESULTS: Five studies using lutein and two studies using astaxanthin met the inclusion criteria. Consumption of lutein and its isomer showed consistent results in selective improvement of visual episodic memory in young and middle-aged adults while inhibition was observed in middle-aged and older adults. One of the two included astaxanthin studies reported a significant improvement of verbal episodic memory performance in middle-aged adults. CONCLUSION: This SR showed that the 10 mg lutein per day for twelve months can lead to improvement of cognitive functions. Due to the small number of studies, it is difficult to conclude whether astaxanthin would have a positive effect on cognitive functions.
Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice. 国際誌

Akira Uruno, Daisuke Matsumaru, Rie Ryoke, Ritsumi Saito, Shiori Kadoguchi, Daisuke Saigusa, Takashi Saito, Takaomi C Saido, Ryuta Kawashima, Masayuki Yamamoto

Molecular and cellular biology　40　(6)　2020年2月27日

DOI： 10.1128/MCB.00467-19 　

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Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer's disease (AD), AD model AppNL-G-F/NL-G-F knock-in (AppNLGF ) mice were studied in combination with genetic Nrf2 induction model Keap1FA/FA mice. While AppNLGF mice displayed shorter latency to escape than wild-type mice in the passive-avoidance task, the impairment was improved in AppNLGF ::Keap1FA/FA mice. Matrix-assisted laser desorption ionization-mass spectrometry imaging revealed that reduced glutathione levels were elevated by Nrf2 induction in AppNLGF ::Keap1FA/FA mouse brains compared to AppNLGF mouse brains. Genetic Nrf2 induction in AppNLGF mice markedly suppressed the elevation of the oxidative stress marker 8-OHdG and Iba1-positive microglial cell number. We also determined the plasmalogen-phosphatidylethanolamine (PlsPE) level as an AD biomarker. PlsPE containing polyunsaturated fatty acids was decreased in the AppNLGF mouse brain, but Nrf2 induction attenuated this decline. To evaluate whether pharmacological induction of Nrf2 elicits beneficial effects for AD treatment, we tested the natural compound 6-MSITC [6-(methylsulfinyl)hexyl isothiocyanate]. Administration of 6-MSITC improved the impaired cognition of AppNLGF mice in the passive-avoidance task. These results demonstrate that the induction of Nrf2 ameliorates cognitive impairment in the AD model mouse by suppressing oxidative stress and neuroinflammation, suggesting that Nrf2 is an important therapeutic target of AD.
複雑な社会技術システムにおける想定外事象対応の機能的MRI：課題成績と問題対応特性は問題解決脳領域の低活動と関連する査読有り

三浦直樹, 吉井慶人, 高橋信, 杉浦元亮, 川島隆太

ヒューマンインタフェース学会論文誌　22　(1)　43-54　2020年2月

DOI： 10.11184/his.22.1_43 　
管制官の空間情報処理の神経基盤：機能的MRIを用いた研究査読有り

高橋信, 芳賀清憲, 三浦直樹, 青山久枝, 狩川大輔, 関口敦, 川島隆太

ヒューマンインタフェース学会論文誌　22　(1)　35-42　2020年2月

DOI： 10.11184/his.22.1_35 　
Convergent creative thinking performance is associated with white matter structures: Evidence from a large sample study. 国際誌招待有り査読有り

Hikaru Takeuchi, Yasuyuki Taki, Izumi Matsudaira, Shigeyuki Ikeda, Kelssy H Dos S Kawata, Rui Nouchi, Kohei Sakaki, Seishu Nakagawa, Takayuki Nozawa, Susumu Yokota, Tsuyoshi Araki, Sugiko Hanawa, Ryo Ishibashi, Shohei Yamazaki, Ryuta Kawashima

NeuroImage　210　116577-116577　2020年1月22日

DOI： 10.1016/j.neuroimage.2020.116577 　

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In laboratory settings, creativity is measured using tasks of divergent as well as convergent thinking. It has been suggested that brain connectivity is important for creativity. In the present study, we investigated the associations of convergent thinking performance of compound Remote Associates Test (CRAT) with fractional anisotropy (FA) in diffusion tensor imaging and regional white matter (WM) volume (rWMV) in voxel-based morphometry in a large sample of healthy young adults (360 males and 280 females; mean age: 20.9 years, SD = 1.6). We showed that CRAT performance was positively correlated with WM pathway property (i.e., FA) in the left fronto-occipital fasciculus and the left inferior longitudinal fasciculus, which play important roles in processing of language and concept. Further, CRAT performance was negatively correlated with rWMV in the widespread frontal temporal subcortical and cerebellar WM areas, suggesting the unique association of convergent thinking with WM connectivity.
A Single 30 Minutes Bout of Combination Physical Exercises Improved Inhibition and Vigor-Mood in Middle-Aged and Older Females: Evidence From a Randomized Controlled Trial. 国際誌

Rui Nouchi, Haruka Nouchi, Ryuta Kawashima

Frontiers in aging neuroscience　12　179-179　2020年

DOI： 10.3389/fnagi.2020.00179 　

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Background: Long-term combination of physical exercises has reported benefits for cognitive functions and mood states. However, it remains unclear whether a single bout of combination exercise training has acute positive effects on cognitive functions and mood states in middle-aged and older women. It is important to investigate acute effect of physical exercise because it would help to understand a mechanism of benefits of physical exercise. The purpose of this study was to investigate 30 min of a single bout of combination exercise training on cognition and mood states in middle-aged and older females. Methods: In this single-blinded randomized control trial (RCT), middle-aged and older females were assigned randomly to two groups: a combination exercise group and a no-exercise control group. The former group did the combination exercise training (aerobic, strength, and stretching exercises) for 30 min. Meanwhile, the latter group did not do any exercise and waited for 30 min. We measured cognitive functions and mood performance states before and after the exercise or control interventions. Results: Our main results demonstrated that, compared to the control group, the combination exercise improved inhibition (reverse Stroop and Stroop) and increased vigor-activity mood scores in both middle-aged and older groups. We also found that the only combination exercise group showed the significant positive correlations between improved inhibition performance and improved vigor-activity mood. Discussion: This randomized controlled trial revealed the acute benefits of combination exercise on inhibition in executive functions and vigor-activity in the healthy middle-aged and older females. Our results provided the scientific evidence related to acute effects of the single bout of the combination exercise training. It suggests that we would be better to do the 30 min physical exercise for our health. Clinical Trial Registration: This trial was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN000029681). Registered 24 October 2017, https://upload.umin.ac.jp/cgi-bin/ctr/ctr_view_reg.cgi?recptno=R000033922.
The Role of Cognitive Control in Age-Related Changes in Well-Being. 国際誌

Ayano Yagi, Rui Nouchi, Kou Murayama, Michiko Sakaki, Ryuta Kawashima

Frontiers in aging neuroscience　12　198-198　2020年

DOI： 10.3389/fnagi.2020.00198 　

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Maintaining emotional well-being in late life is crucial for achieving successful and healthy aging. While previous research from Western cultures has documented that emotional well-being improves as individuals get older, previous research provided mixed evidence on the effects of age on well-being in Eastern Asian cultures. However, previous studies in East Asia do not always take into account the effects of cognitive control-an ability which has been considered as a key to enable older adults to regulate their emotions. In the current study, we tested whether cognitive control abilities interact with age in determining individuals' well-being in 59 Japanese females (age range: 26-79; Mage = 64.95). Participants' mental health and mental fatigue were tracked for 5 years together with their cognitive control abilities. We found that as individuals became older, they showed improved mental health and decreased mental fatigue. In addition, we found a quadratic effect of age on mental fatigue, which was further qualified by baseline cognitive control abilities. Specifically, in those who had a lower level of cognitive control abilities, mental fatigue declined until the mid-60s, at which point it started increasing (a U-shape effect). In contrast, in those who had a higher level of cognitive control ability, mental fatigue showed a steady decrease with age even after their mid-60s. These results suggest that whether advancing age is associated with positive vs. negative changes in well-being depends on cognitive control abilities, and that preserved cognitive control is a key to maintain well-being in late life.
A single nucleotide polymorphism (-250 A/C) of the GFAP gene is associated with brain structures and cerebral blood flow. 国際誌

Yuta Takahashi, Hikaru Takeuchi, Mai Sakai, Zhiqian Yu, Yoshie Kikuchi, Fumiaki Ito, Hiroo Matsuoka, Osamu Tanabe, Jun Yasuda, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

Psychiatry and clinical neurosciences　74　(1)　49-55　2020年1月

DOI： 10.1111/pcn.12932 　

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AIM: Glial fibrillary acidic protein (GFAP), the intermediate filament protein expressed in astrocytes, plays a key role in many aspects of brain function through communication with neurons or blood vessels. A common single nucleotide polymorphism (SNP), GFAP -250 C/A (rs2070935), is associated with the transcriptional regulation of GFAP, which can potentially result in the genotype-specific brain structure. This study aimed to verify the biological effects of the GFAP variants on brain structure and function. METHODS: We investigated the associations between the GFAP variants and magnetic resonance imaging findings, including gray and white matter volumes, white matter integrity, and resting arterial blood flow, from 1212 healthy Japanese subjects. RESULTS: The GFAP -250 C/A genotype was significantly associated with total gray matter volume, total white matter volume, average mean diffusivity, and mean cerebral blood flow. In voxel-by-voxel analyses, the GFAP genotype showed significant associations with the regional gray and white matter volumes in the inferior frontal lobe and corpus callosum, the regional mean diffusivity in the left posterior region, and the regional cerebral blood flow throughout the brain. CONCLUSION: This study revealed a common SNP that is significantly associated with multiple global brain structure parameters.
MEGによるてんかん研究 up-to-date 覚醒時の体性感覚誘発磁界第1波の信号強度抑制は側頭葉てんかんの罹病期間と相関する

石田誠, 神一敬, 柿坂庸介, 菅野彰剛, 川島隆太, 中里信和

日本生体磁気学会誌　33　(1)　62-63　2020年
出版者・発行元：日本生体磁気学会
ISSN：0915-0374
口唇裂手術後の口唇感覚に関する体性感覚誘発磁界を用いた客観的評価

北山ちひろ, 菅野彰剛, 日原大貴, 島田栄理遣, 金高弘恭, 中里信和, 川島隆太, 五十嵐薫

日本生体磁気学会誌　33　(1)　161-163　2020年
出版者・発行元：日本生体磁気学会
ISSN：0915-0374
Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms 査読有り

Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Kotozaki Y, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakaki K, Nozawa T, Ikeda S, Yokota S, Magistro D, Sassa Y, Kawashima R

Scientific Reports　in press　2020年
Effects of training of shadowing and reading aloud of second language on working memory and neural systems 査読有り

Takeuchi H, Maruyama T, Taki Y, Motoki K, Jeong H, Kotozaki Y, Shinada T, Nakagawa S, Nouchi R, Iizuka K, Yokoyama R, Yamamoto Y, Hanawa S, Araki T, Sakaki K, Sasaki Y, Magistro D, Kawashima R

Brain Imaging and Behavior　in press　2020年
Somatosensory evoked magnetic fields of periodontal mechanoreceptors. 国際誌査読有り

Hiroki Hihara, Hiroyasu Kanetaka, Akitake Kanno, Eriya Shimada, Satoko Koeda, Ryuta Kawashima, Nobukazu Nakasato, Keiichi Sasaki

Heliyon　6　(1)　e03244　2020年1月

DOI： 10.1016/j.heliyon.2020.e03244 　

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To evaluate the localization of responses to stimulation of the periodontal mechanoreceptors in the primary somatosensory cortex, somatosensory evoked fields (SEFs) were measured for stimulation of the left mandibular canine and first molar using magnetoencephalography in 25 healthy subjects. Tactile stimulation used a handmade stimulus device which recorded the trigger at the moment of touching the teeth.SEFs for the canine and first molar were detected in 20 and 19 subjects, respectively. Both responses were detected in the bilateral hemispheres. The latency for the canine was 62.1 ± 12.9 ms in the ipsilateral hemisphere and 65.9 ± 14.8 ms in the contralateral hemisphere. The latency for the first molar was 47.4 ± 6.6 ms in the ipsilateral hemisphere and 47.8 ± 9.1 ms in the contralateral hemisphere. The latency for the first molar was significantly shorter than that for the canine. The equivalent current dipoles were estimated in the central sulcus and localized anteroinferiorly compared to the locations for the SEFs for the median nerve. No significant differences in three-dimensional coordinates were found between the canine and first molar. These findings demonstrate the precise location of the teeth within the orofacial representation area in the primary somatosensory cortex.
Originality of divergent thinking is associated with working memory–related brain activity: evidence from a large sample study 査読有り

Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Kotozaki Y, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakak K, Sassa Y, Nozawa T, Ikeda S, Yokota S, Magistro D, Kawashima R

Neuroimage　in press　2020年
Loneliness modulates automatic attention to warm and competent faces: Preliminary evidence from an eye-tracking study 国際誌査読有り

Saito Toshiki, Motoki Kosuke, Rui Nouchi, Ryuta Kawashima, Sugiura Motoaki

Frontiers in Psychology　10　2967-2967　2020年1月

DOI： 10.3389/fpsyg.2019.02967 　

ISSN：1664-1078
Virtual training leads to real acute physical, cognitive, and neural benefits on healthy adults: study protocol for a randomized controlled trial

Dalila Burin, Noriki Yamaya, Rie Ogitsu, Ryuta Kawashima

Trials　20　(1)　2019年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/s13063-019-3591-1 　

eISSN：1745-6215

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<title>Abstract</title><sec><title>Background</title>Keeping a certain level of physical activity has beneficial effects on the body itself but also, surprisingly, on cognition: specifically, physical high-intensity intermittent aerobic exercise (HIE) can show improvement on cognitive executive functions. Although, in some cases performing strength or aerobic training is problematic or not feasible. Immersive virtual reality (IVR) can induce the illusory feeling of ownership and agency over a moving virtual body, therefore showing comparable physiological reactions: for example, if an individual is sitting on a chair but his virtual body climbs a hill, the individual’s heart rate increases coherently, as if he is actually walking. In this study, we investigate whether this same illusion can show beneficial consequences on the body as well as on executive functions (using the color-word matching Stroop task) and on its neural substrates (using functional near-infrared spectroscopy [fNIRS]). </sec><sec><title>Methods</title>In a cross-over randomized controlled trial, 30 healthy young adults will experience HIE training in IVR (i.e. the virtual body will perform eight sets of 30 s of running followed by 30 s of slow walking, while the participant is completely still) according to two random-ordered conditions: during the experimental condition, the virtual body is displayed in first-person perspective (1PP), while in the control condition, the virtual body is displayed in third-person perspective (3PP). To confirm that individuals have the illusion of ownership and agency over the virtual body in 1PP (and not in 3PP), we will record the heart rate, in addition to subjective questionnaires. Before and after every IVR sessions (one week apart), we will measure cortical hemodynamic changes in the participants’ prefrontal cortex using the fNIRS device during the Stroop task’s execution. </sec><sec><title>Discussion</title>From a theoretical perspective, we could prove that the sense of body ownership and agency can modulate physical and cognitive parameters, even in the absence of actual movements; from a clinical perspective, these results could be useful to train cognition and body simultaneously, in a completely safe environment. </sec><sec><title>Trial registration</title>University Hospital Medical Information Network Clinical Trial Registry,<ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000039052">UMIN000034255</ext-link>. Registered on 1 October 2018. </sec>
The pitfall of empathic concern with chronic fatigue after a disaster in young adults. 国際誌査読有り

Seishu Nakagawa, Motoaki Sugiura, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Sugiko Hanawa, Tsuyoshi Araki, Atsushi Sakuma, Ryuta Kawashima

BMC psychiatry　19　(1)　338-338　2019年11月4日

DOI： 10.1186/s12888-019-2323-0 　

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BACKGROUND: Empathic concern (EC) is an important interpersonal resilience factor that represents positive adaptation, such as "relating to others" (a factor of posttraumatic growth [PTG]) after disaster. However, controversy exists regarding whether the changes in EC (e.g., the intra-personal change between the acute phase and the disillusionment phase) positively or negatively affect mental health after a disaster. We hypothesized that increased EC may increase chronic fatigue due to over-adjustment (hypothesis 1). We also hypothesized that increasing the changes in "relating to others" could decrease the changes in chronic fatigue (hypothesis 2). METHODS: Forty-nine young, healthy volunteers (M/F: 36/13; age at 3 months after the disaster [3 months]: mean ± SD: 21.1 ± 1.7 years) underwent assessments of EC using the Japanese version of the Interpersonal Reactivity Index, chronic fatigue using the Japanese version of the Checklist Individual Strength (CIS-J) questionnaire, and "relating to others" using the Japanese version of the PTG inventory during the acute phase (3 months) and the disillusionment phase (1 year after the disaster). Pearson product moment correlations at 3 months and 1 year were determined for all scores related to EC. The changes (delta = degree of change from 3 months to 1 year) or scores at 1 year were entered into linear structural equation systems to test the hypotheses. RESULTS: The delta of EC positively affected the delta of the CIS-J, and the delta of relating to others negatively affected the delta of the CIS-J. Both the EC and relating to others scores were negatively associated with the CIS-J score at 1 year. These results were in accordance with hypothesis 1 and 2. CONCLUSIONS: We demonstrated the opposite effects of 2 types of ECs, i.e., stability (inherent disposition) and flexibility (degree of change), on the degree of chronic fatigue. Increasing EC with increasing chronic fatigue, but not the change in relating to others, may be a red flag for individuals during the disillusionment phase.
Corrigendum to "Anxiety increases visual attention to hedonic foods: A preliminary eye-tracking study on the impact of the interplay between integral and incidental affect on foods" [Appetite 137 (1 June 2019) 218-225]. 国際誌

Kosuke Motoki, Toshiki Saito, Rui Nouchi, Ryuta Kawashima, Motoaki Sugiura

Appetite　142　104400-104400　2019年11月1日

DOI： 10.1016/j.appet.2019.104400 　
脳活動からの自動車運転危険予測:シミュレータ fMRI 実験

大場健太郎, 浜田康司, 廣瀬正明, 川島隆太, 杉浦元亮

計測自動制御学会システム・情報部門学術講演会2019(SSI2019)講演論文集　1108　2019年11月
Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images. 国際誌査読有り

Yasuko Tatewaki, Tatsushi Mutoh, Kazuko Omodaka, Benjamin Thyreau, Izumi Matsudaira, Hiroaki Furukawa, Keiji Yamada, Keiko Kunitoki, Ryuta Kawashima, Toru Nakazawa, Yasuyuki Taki

Scientific reports　9　(1)　15148-15148　2019年10月22日

DOI： 10.1038/s41598-019-51611-0 　

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Elongated axial length of the eye increases the morbidity of glaucoma. Myopia also associates with elongated axial length, and such ellipsoid shape of the eyeball strongly contributes its pathogenesis. Morphological features of the eyeballs, which could be important factors for developing glaucoma, have not been well described. The aim of this study was to investigate the three-dimensional (3D) topographic features of glaucomatous eyeballs with/without myopia to evaluate the potential of those features for predicting glaucoma. Using a 3.0-tesla MRI, volume-isotropic turbo-spin-echo acquisition T2-weighted images were obtained from 55 patients with glaucoma and 22 controls to delineate the eyeballs. Eyeball volumes, axial lengths and transverse lengths were semi-automatically calculated and compared between four groups: normal, myopia, glaucoma, and glaucoma with myopia. Both glaucoma and myopia increased the eyeball volume compared to the normal eyes. An increased anisotropy ratio (axial/transversus length) was observed in myopic eyes compared to normal, whereas in the glaucomatous eyes, with or without myopia, no increase in anisotropy ratio was observed. Increasing volume of eyes can be caused by myopia and glaucoma. Myopic eyes were ellipsoid in shape, but there was less anisotropy and a near-spherical shape in glaucomatous eyes, even in glaucomatous myopic eyes.
Common neural value representations of hedonic and utilitarian products in the ventral striatum: An fMRI study 査読有り

Motoki K, Sugiura M, Kawashima R

Scientific Reports　2019年10月
Does Video Gaming Have Impacts on the Brain: Evidence from a Systematic Review. 国際誌

Denilson Brilliant T, Rui Nouchi, Ryuta Kawashima

Brain sciences　9　(10)　2019年9月25日

DOI： 10.3390/brainsci9100251 　

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Video gaming, the experience of playing electronic games, has shown several benefits for human health. Recently, numerous video gaming studies showed beneficial effects on cognition and the brain. A systematic review of video gaming has been published. However, the previous systematic review has several differences to this systematic review. This systematic review evaluates the beneficial effects of video gaming on neuroplasticity specifically on intervention studies. Literature research was conducted from randomized controlled trials in PubMed and Google Scholar published after 2000. A systematic review was written instead of a meta-analytic review because of variations among participants, video games, and outcomes. Nine scientific articles were eligible for the review. Overall, the eligible articles showed fair quality according to Delphi Criteria. Video gaming affects the brain structure and function depending on how the game is played. The game genres examined were 3D adventure, first-person shooting (FPS), puzzle, rhythm dance, and strategy. The total training durations were 16-90 h. Results of this systematic review demonstrated that video gaming can be beneficial to the brain. However, the beneficial effects vary among video game types.
Prior physical synchrony enhances rapport and inter-brain synchronization during subsequent educational communication. 査読有り

Nozawa T, Sakaki K, Ikeda S, Jeong H, Yamazaki S, Kawata KHDS, Kawata NYDS, Sasaki Y, Kulason K, Hirano K, Miyake Y, Kawashima R

Scientific reports　9　(1)　12747　2019年9月
出版者・発行元：
DOI： 10.1038/s41598-019-49257-z 　

eISSN：2045-2322
Mean diffusivity associated with trait emotional intelligence. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Social cognitive and affective neuroscience　14　(8)　871-883　2019年8月31日

DOI： 10.1093/scan/nsz059 　

ISSN：1749-5016

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Previous neuroimaging studies have suggested that the neural bases of trait emotional intelligence (TEI) lie in the social cognition network (SCN) and the somatic marker circuitry (SMC). The current study was the first to investigate the associations of total TEI factors and subfactors with mean diffusivity (MD) of these networks as well as regional MD of the dopaminergic system (MDDS). We found that TEI intrapersonal factor score and total TEI score were negatively correlated with regional MDDS in the vicinity of the right putamen and right pallidum and that TEI intrapersonal factor score was negatively correlated with MD values of the fusiform gyrus. Total TEI score and TEI factor scores were positively correlated with MD values of various areas within or adjacent to SCN components, SMC structures and the lateral prefrontal cortex (LPFC). Our MD findings demonstrated the importance of the dopaminergic system to TEI and implicate the SCN, SMC and LPFC in TEI. Future studies are required to investigate the implications of positive and negative associations with MD values.
Mean diffusivity related to rule-breaking guilt: the Macbeth effect in the sensorimotor regions. 国際誌査読有り

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Scientific reports　9　(1)　12227-12227　2019年8月22日

DOI： 10.1038/s41598-019-48654-8 　

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Guilt, a self-conscious emotion, includes self-focused role taking and also correlates with other-oriented role-taking. Excess guilt proneness might be relevant to obsessive compulsive disorders. The white matter (WM) neural correlates of the degree of guilt have not yet been determined. We hypothesized that the WM structures involved in feelings of guilt are associated with social and moral cognition (inferior parietal lobule [IPL], prefrontal cortex [PFC], and cingulate), and aimed to visualize this using diffusion MRI. We investigated the association between regional WM structures (WM volume, and fractional anisotropy, and mean diffusivity [MD]), and feelings of guilt in 1196 healthy, young students using MRI and the Guilty Feeling Scale, which comprises interpersonal situation (IPS; guilt from hurting friends) and rule-breaking situation (RBS; deontological guilt) scores. The primary novel finding presented here is that MD in the right somatosensory and motor cortices from arm to hand were positively correlated with RBS scores. Further, consistent with our hypothesis, RBS scores were positively correlated with MD in the same regions. These results would be predicted by the Macbeth effect, an obsession with dirt leading to hand-washing rituals resulting from guilt, made famous by the Shakespearian character Lady Macbeth. "What, will these hands ne'er be clean?" William Shakespeare (Shakespeare, 1606) Macbeth.
Does Incidental Pride Increase Competency Evaluation of Others Who Appear Careless? Discrete Positive Emotions and Impression Formation 国際誌査読有り

Saito Toshiki, Motoki Kosuke, Rui Nouchi, Ryuta Kawashima, Sugiura Motoaki

PLOS ONE　14　(8)　e0220883　2019年8月

DOI： 10.1371/journal.pone.0220883 　
A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity. 国際誌査読有り

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Cerebral cortex (New York, N.Y. : 1991)　29　(8)　3211-3219　2019年7月22日

DOI： 10.1093/cercor/bhy189 　

ISSN：1047-3211

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Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we investigated the sex-specific effects of the CACNA1C variant rs1024582 on psychiatry-related traits, brain activity during tasks and rest, and brain volume in 1207 normal male and female subjects. After correcting for multiple comparisons, there were significant interaction effects between sex and the minor allele of this polymorphism on the hostile behavior subscale scores of the Coronary-Prone Type Scale mediated by higher scores in female carriers of the minor allele. Imaging analyses revealed significant interaction effects between sex and the minor allele on fractional amplitude of low-frequency fluctuations in the right dorsolateral prefrontal cortex and on brain activity during the 2-back task in areas of the right posterior cingulate cortex, right thalamus, and right hippocampus, which were all mediated by reduced activity in female carriers of the minor allele. Our results demonstrated that the rs1024582 risk variant of CACNA1C is associated with reduced activity in the frontolimbic regions at rest and during a working memory task as well as with greater hostility in females in the healthy population.
Neural responses to action contingency error in different cortical areas are attributable to forward prediction or sensory processing 国際誌査読有り

Kikuchi Tatsuo, Sugiura Motoaki, Yamamoto Yuki, Sasaki Yukako, Hanawa Sugiko, Sakuma Atsushi, Matsumoto Kazunori, Matsuoka Hiroo, Kawashima Ryuta

SCIENTIFIC REPORTS　9　(1)　9847-9847　2019年7月8日

DOI： 10.1038/s41598-019-46350-1 　

ISSN：2045-2322
Hybrid magneto-fluorescent nano-probe for live apoptotic cells monitoring at brain cerebral ischemia. 国際誌査読有り

Moataz M Mekawy, Atsushi Saito, Akira Sumiyoshi, Jorge J Riera, Hiroaki Shimizu, Ryuta Kawashima, Teiji Tominaga

Materials science & engineering. C, Materials for biological applications　100　485-492　2019年7月

DOI： 10.1016/j.msec.2019.03.032 　

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α-Fe2O3 Magnetic nanoparticles (MNPs) have been synthesized, functionalized at silica that ends up with -NH2 group to form FMNPs. Conjugation of FMNPs with a fluorescently-labeled poly-caspase inhibitor valylalanylaspartic acid fluoromethyl ketone (SR-FLICA) which serves as a pan-caspase inhibitor was carried out to form finally a hybrid probe SR-FLICA-FMNPs. This probe could be used as a multimodal magneto-fluorescent platform for live apoptotic cells monitoring using MR and fluorescence imaging techniques. Characterization results of the as-synthesized MNPs and functionalized FMNPs by SEM, TEM, N2 isotherm, XRD and magnetic VSM showed that, a controlled morphological structure of MNPs could be synthesized with cubic-shaped, ferromagnetic, base-centered orthorhombic space group R3c and average size of 45.8 ± 3.2 and 50.3 ± 1.6 nm for MNPs and FMNPs, respectively. Phantom MRI experimental results of the examined MNPs and FMNPs confirmed the concentration dependency nature of T2 signal reduction. In addition, in vitro and in vivo sensing studies on our conjugated hybrid multifunctional probe SR-FLICA-FMNPs using 9 L gliosarcoma cells confirmed that; it could positively intact within the astrocytes and the nuclei of the apoptotic cells taking into account the starting material's cytotoxicity. Several histo-chemical protocols could be examined to confirm such behavior. Confocal and fluorescence microscopes' results of the histological stained apoptotic cells confirmed positive and specific expressions of our designed probe. MRI monitoring results of apoptotic rat models after focal brain transient cerebral ischemia showed a remarkable time-dependent reduction of T2* weighted signal up to 4 h indicating that our newly designed hybrid probe has long blood circulation and could be used as a future contrasting agent. Moreover, the distribution of our probe was evaluated by subtracting the T2* signal images before and after injection with SR-FLICA-FMNPs and was significantly correlated with the histological findings by staining via terminal deoxynucleotidyl transferase-mediated uridine 5'-triphosphate-biotin nick end labeling. Moreover, clearance study confirmed that; our magneto-fluorescent hybrid probe could be cleared through liver Kupffer cells. Thus; the newly developed SR-FLICA-FMNPs could be considered as a future multifunctional probe for in vitro and in vivo apoptotic cells monitoring.
Empathizing associates with mean diffusivity. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Scientific reports　9　(1)　8856-8856　2019年6月20日

DOI： 10.1038/s41598-019-45106-1 　

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Empathizing is defined as "the drive to identify another's mental states and to respond to these with an appropriate emotion" and systemizing is defined as "the drive to the drive to analyze and construct rule-based systems". While mean diffusivity (MD) has been robustly associated with several cognitive traits and disorders related with empathizing and systemizing, its direct correlation with empathizing and systemizing remains to be investigated. We undertook voxel-by-voxel investigations of regional MD to discover microstructural correlates of empathizing, systemizing, and the discrepancy between them (D score: systemizing - empathizing). Whole-brain analyses of covariance revealed that across both sexes, empathizing was positively correlated with MD of (a) an anatomical cluster that primarily spreads in the areas in and adjacent to the left dorsolateral prefrontal cortex, left anterior to the middle cingulate cortex, and left insula and (b) an anatomical cluster of the left postcentral gyrus and left rolandic operculum. The former overlaps with positive MD correlates of cooperativeness. The D score and systemizing did not show significant correlations. In conclusion, while increased MD has generally been associated with reduced neural tissues and possibly area function, higher empathizing and cooperativeness were commonly reflected by greater MD values in areas (a) that mainly overlap with areas that play a key role in emotional salience and empathy. In addition, higher empathizing was correlated with greater MD values in areas (b) that play a key role in the mirror neuron system.
OLIG2遺伝子多型(rs1059004)と自己スキーマ及び抑うつ症状との関連

小松浩, 竹内光, 菊地淑恵, 小野千晶, 兪志前, 飯塚邦夫, 角藤芳久, 舩越俊一, 大野高志, 川島隆太, 瀧龍之, 富田博秋

精神神経学雑誌　(2019特別号)　S452-S452　2019年6月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
Anxiety increases visual attention to hedonic foods: A preliminary eye-tracking study on the impact of the interplay between integral and incidental affect on foods. 国際誌査読有り

Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

Appetite　137　218-225　2019年6月

DOI： 10.1016/j.appet.2019.02.009 　

ISSN：0195-6663
Association of copper levels in the hair with gray matter volume, mean diffusivity, and cognitive functions. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Brain structure & function　224　(3)　1203-1217　2019年4月

DOI： 10.1007/s00429-019-01830-y 　

ISSN：1863-2653

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Although copper plays a critical role in normal brain functions and development, it is known that excess copper causes toxicity. Here we investigated the associations of copper levels in the hair with regional gray matter volume (rGMV), mean diffusivity (MD), and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that high copper levels were associated mostly with low cognitive abilities (low scores on the intelligence test consisting of complex speed tasks, involving reasoning task, a complex arithmetic task, and a reading comprehension task) as well as lower reverse Stroop interference, high rGMV over widespread areas of the brain [mainly including the bilateral lateral and medial parietal cortices, medial temporal structures (amygdala, hippocampus, and parahippocampal gyrus), middle cingulate cortex, orbitofrontal cortex, insula, perisylvian areas, inferior temporal lobe, temporal pole, occipital lobes, and supplementary motor area], as well as high MD of the right substantia nigra and bilateral hippocampus, which are indicative of low density in brain tissues. These results suggest that copper levels are associated with mostly aberrant cognitive functions, greater rGMV in extensive areas, greater MD (which are indicative of low density in brain tissues) in subcortical structures in the healthy young adults, possibly reflecting copper's complex roles in neural mechanisms.
Neural substrates of self- and external-preoccupation: A voxel-based morphometry study. 国際誌査読有り

Ikeda S, Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakaki K, Nozawa T, Yokota S, Magistro D, Kawashima R

Brain and behavior　9　(6)　e01267　2019年4月

DOI： 10.1002/brb3.1267 　
Light colors and comfortable warmth: Crossmodal correspondences between thermal sensations and color lightness influence consumer behavior 査読有り

Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

Food Quality and Preference　72　45-55　2019年3月

DOI： 10.1016/j.foodqual.2018.09.004 　

ISSN：0950-3293
Round Faces Are Associated with Sweet Foods: The Role of Crossmodal Correspondence in Social Perception. 国際誌査読有り

Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

Foods (Basel, Switzerland)　8　(3)　2019年3月

DOI： 10.3390/foods8030103 　
Mean diffusivity related to collectivism among university students in Japan. 国際誌査読有り

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Scientific reports　9　(1)　1338-1338　2019年2月4日

DOI： 10.1038/s41598-018-37995-5 　

ISSN：2045-2322
Effect of the interaction between BDNF Val66Met polymorphism and daily physical activity on mean diffusivity. 国際誌査読有り

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Brain imaging and behavior　2019年1月7日

DOI： 10.1007/s11682-018-0025-8 　

ISSN：1931-7557

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Numerous studies have reported that the Met allele of the brain-derived neurotrophic factor (BDNF) gene polymorphism reduces neural plasticity. A reduction in mean diffusivity (MD) in diffusion tensor imaging (DTI) characteristically reflects the neural plasticity that involves increased tissue components. In this study, we revealed that the number of Met-BDNF alleles was negatively associated with MD throughout the whole-brain gray and white matter areas of 743 subjects using DTI and whole-brain multiple regression analyses. Within the same sample, the region of interest analysis revealed that the number of Met-BDNF alleles significantly and positively correlated with the mean FA value in the body of the corpus callosum. In addition, we observed interaction effects between BDNF Val66Met polymorphism and daily physical activity levels on MD, but not FA, in significant clusters of the bilateral hemisphere (n = 577 subjects). Post-hoc multiple regression analyses revealed that after correcting for confounding variables, there was a significant negative correlation between the physical activity level and mean MD of the whole brain in the Val/Val group [standardized partial regression coefficient (β) = -0.196, P = 0.005, t = -2.825], but not in the Val/Met (β = 0.050, P = 0.412, t = 0.822) and Met/Met groups (β = 0.092, P = 0.382, t = 0.878). These results underscore the importance of the interaction between physical activity and the BDNF Val66Met polymorphism, which affects the plasticity of neural mechanisms.
Newly Developed TV-Based Cognitive Training Games Improve Car Driving Skills, Cognitive Functions, and Mood in Healthy Older Adults: Evidence From a Randomized Controlled Trial. 国際誌

Rui Nouchi, Akiko Kobayashi, Haruka Nouchi, Ryuta Kawashima

Frontiers in aging neuroscience　11　99-99　2019年

DOI： 10.3389/fnagi.2019.00099 　

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Background: Cognitive training in a laboratory improves car driving skills of older car drivers. However, it remains unclear whether other types of cognitive training at home have beneficial effects on driving skills. Using our developed cognitive training games that can be played on a television with a set-top box in a person's home, we investigated the effects of a 6-week cognitive training program on driving skills, which included on-road evaluation (primary outcome), and cognitive functions and emotional states (secondary outcome) in older people. Methods: In this double-blinded randomized control trial (RCT), 60 older licensed drivers were randomly assigned into one of the two groups: a cognitive training game for car driving (CTCD) group and an active control cognitive training game (ACT) group. Participants in the CTCD group played the CTCD (processing speed, dual attention, and speed prediction) for 20 min in five sessions per week for 6 weeks. Participants in the ACT group played the ACT (selecting the larger number; selecting a number from largest to smallest; play a game of rock, article, scissors) for 20 min in five sessions per week for 6 weeks. We measured driving skills, various cognitive functions, and emotional states before and after the 6-week intervention period. Results: Our main results showed that compared to the ACT group, the CTCD group demonstrated improved driving skills (adjusted p = 0.034). Moreover, the CTCD group demonstrated improved inhibition (stroop, adjusted p = 0.042: reverse Stroop, adjusted p = 0.043) and processing speed performance symbol search (SS), adjusted p = 0.049; digit symbol coding (adjusted p = 0.047), compared to the ACT group. The CTCD group scored higher on vigor-activity mood (adjusted p = 0.041) as measured using the Profile of Mood State. Discussion: This randomized controlled trial provides scientific evidence for the benefits of the 6-week CTCD program on driving skills and cognitive functions, such as processing speed, inhibition, and vigor-activity mood, in healthy older people. Our results suggest that cognitive training is useful to improve the driving skills of older adults. Trial registration: This trial was registered at The University Hospital Medical Information Network Clinical Trials Registry (UMIN 000029769). Registered 31 October 2017, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034010.
Study Protocol: Does an Acute Intervention of High-Intensity Physical Exercise Followed by a Brain Training Video Game Have Immediate Effects on Brain Activity of Older People During Stroop Task in fMRI?-A Randomized Controlled Trial With Crossover Design. 国際誌

Robin Maximilian Himmelmeier, Rui Nouchi, Toshiki Saito, Dalila Burin, Jens Wiltfang, Ryuta Kawashima

Frontiers in aging neuroscience　11　260-260　2019年

DOI： 10.3389/fnagi.2019.00260 　

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Background: Elderly people are affected by processes leading to decline in various aspects of daily living that impair their quality of life. Regarding neurological aspects, executive functions have been shown to be valuable for daily life and to slow decline during aging. Most intervention studies intended to improve cognitive functions during aging specifically address long-term destructive processes and countermeasures. However, to an increasing degree, studies also investigate the acute benefits that prove to be useful for daily life, such as physical exercise or video games in the form of exercise video gaming ("exergaming"). Because little is known about the change in cognitive ability following acute intervention of a combination of physical exercise and video gaming, especially for older people, this work is designed as an attempt to address this matter. Methods: This study is a randomized crossover controlled trial to test the response to an acute bout of high-intensity physical exercise followed by a short session with a brain training (Brain Age) video game in physically active and cognitively healthy older adults (60-70 years). The response is measured using Stroop task performance (cognitive task for executive function) and related brain activity assessed with functional magnetic resonance imaging (fMRI). The control conditions are low-intensity physical exercise and Tetris for video gaming. Discussion: This study is intended to provide insight into the alteration of executive function and its related brain activity from an acute intervention with a combination of physical exercise and video gaming in older people. The protocol might not be implementable in daily life to improve cognitive abilities. However, the results can support future studies that investigate cognition and the combination of physical exercise and video gaming. Moreover, it can provide real-life implications. Trial registration: This trial was registered in The University Hospital Medical Information Network Clinical Trials Registry (UMIN000033054). Registered 19 July 2018, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000037687.
Emerging Cognitive Intervention Technologies to Meet the Needs of an Aging Population: A Systematic Review. 国際誌

Fady Alnajjar, Sumayya Khalid, Alistair A Vogan, Shingo Shimoda, Rui Nouchi, Ryuta Kawashima

Frontiers in aging neuroscience　11　291-291　2019年

DOI： 10.3389/fnagi.2019.00291 　

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Background: Cognitive training helps to promote healthy aging and ease activities of daily living for older adults. Recently, experiments have been conducted using robots to perform this cognitive training. Methods: A review was conducted to examine the effects of computer-based cognitive interventions for older adults who were either healthy or experiencing mild cognitive impairment (MCI). A second study also examined the evolution of socially assistive robots (SAR) and their effectiveness at administering cognitive training for older adults. Results: Eighty-one studies published between 2009 and 2019 were identified for review, 56 of which focused on computerized cognitive training (CCT) while 25 examined the use of robotics. Twenty-four of the 56 CCT studies met the inclusion criteria. These were further classified into two groups: studies which used self-designed programs, and studies using commercially available ones. Of the 25 studies examining the use of robotics in cognitive intervention 7 met the inclusion criteria. Review shows that CCT improves cognitive function but that robots are more effective tools for improving cognition. Conclusion: It can be concluded that CCT is beneficial for older adults and though there are drawbacks to this approach they are overcome by the introduction of robots into the training process. Culture, language, and socio-economic considerations vis-a-vis robot design and training methodology should be included in future research.
Two components in body image disturbance are associated with differential neural basis 査読有り

Hamamoto Yumi, Suzuki Shinsuke, Yamazaki Shohei, Motoki Kosuke, Oba Kentaro, Kawashima Ryuta, Sugiura Motoaki

PSYCHOTHERAPY AND PSYCHOSOMATICS　88　53　2019年

ISSN：0033-3190
A Sweet Voice: The Influence of Cross-Modal Correspondences Between Taste and Vocal Pitch on Advertising Effectiveness. 国際誌査読有り

Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

Multisensory research　32　(4-5)　401-427　2019年1月

DOI： 10.1163/22134808-20191365 　

ISSN：2213-4794
Taking another’s perspective promotes right parieto-frontal activity that reflects open-minded thought 査読有り

Naoki Miura, Motoaki Sugiura, Takayuki Nozawa, Yuki Yamamoto, Yukako Sasaki, Yumi Hamamoto, Shohei Yamazaki, Kanan Hirano, Makoto Takahashi, Ryuta Kawashima

Social Neuroscience　0　(0)　1-14　2019年
出版者・発行元： Routledge
DOI： 10.1080/17470919.2019.1710249 　

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PMID: 31888419
rs1360780 of the FKBP5 gene modulates the association between maternal acceptance and regional gray matter volume in the thalamus in children and adolescents. 査読有り

Matsudaira I, Oba K, Takeuchi H, Sekiguchi A, Tomita H, Taki Y, Kawashima R

PloS one　14　(8)　e0221768-e0221768　2019年
出版者・発行元：
DOI： 10.1371/journal.pone.0221768 　

eISSN：1932-6203
General intelligence is associated with working memory-related brain activity: new evidence from a large sample study. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Brain structure & function　223　(9)　4243-4258　2018年12月

DOI： 10.1007/s00429-018-1747-5 　

ISSN：1863-2653

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Psychometric intelligence is closely related to working memory capacity. Here we aim to determine the associations of neural activation patterns during the N-back working memory paradigm with psychometric intelligence and working memory performance. We solved the statistical problems of previous studies using (1) a large cohort of 1235 young adults and (2) robust voxel-by-voxel permutation-based statistics at the whole-brain level. Many of the significant correlations were weak, and our findings were not consistent with those of previous studies. We observed that many of the significant correlations involved brain areas in the periphery or boundaries between the task-positive network (TPN) and task-negative network (TNN), suggesting that the expansion of the TPN or TNN is associated with greater cognitive ability. Lower activity in TPN and less task-induced deactivation (TID) in TNN were associated with greater cognitive ability. These findings indicate that subjects with greater cognitive ability have a lower brain response to task demand, consistent with the notion that TID in TNN reflects cognitive demand but partly inconsistent with the prevailing neural efficiency theory. One exception was the pre-supplementary motor area, which plays a key role in cognitive control and sequential processing. In this area, intelligent subjects demonstrated greater activity related to working memory, suggesting that the pre-supplementary motor area plays a unique role in the execution of working memory tasks in intelligent subjects.
Impact of frequency of internet use on development of brain structures and verbal intelligence: Longitudinal analyses. 国際誌査読有り

Takeuchi H, Taki Y, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R

Human brain mapping　39　(11)　4471-4479　2018年11月

DOI： 10.1002/hbm.24286 　

ISSN：1065-9471
回想による楽観性向上の個人差とその神経基盤の検討

大場健太郎, Barthel Marie, 阿部光一, 平野香南, 石橋遼, 野内類, 川島隆太, 杉浦元亮

健康心理学会　31　(0)　2018年8月14日
出版者・発行元：一般社団法人日本健康心理学会
Approach or avoidance: Neural correlates of intelligence evaluation from faces 国際誌査読有り

Akimoto Yoritaka, Yamazaki Ryuichi, Sugiura Motoaki, Nouchi Rui, Terao Chiaki, Tsukiura Takashi, Kawashima Ryuta

EUROPEAN JOURNAL OF NEUROSCIENCE　48　(1)　1680-1690　2018年7月

DOI： 10.1111/ejn.13974 　

ISSN：0953-816X
Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain

Mai Sakai, Hikaru Takeuchi, Zhiqian Yu, Yoshie Kikuchi, Chiaki Ono, Yuta Takahashi, Fumiaki Ito, Hiroo Matsuoka, Osamu Tanabe, Jun Yasuda, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

Psychiatry and Clinical Neurosciences　72　(6)　409-422　2018年6月

DOI： 10.1111/pcn.12649 　

ISSN：1323-1316

eISSN：1440-1819
Mean Diffusivity in the Dopaminergic System and Neural Differences Related to Dopaminergic System

Hikaru Takeuchi, Ryuta Kawashima

Current Neuropharmacology　16　(4)　460-474　2018年5月1日
出版者・発行元： Bentham Science Publishers Ltd.
DOI： 10.2174/1570159x15666171109124839 　

ISSN：1570-159X
Shorter sleep duration and better sleep quality are associated with greater tissue density in the brain. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Scientific reports　8　(1)　5833-5833　2018年4月11日

DOI： 10.1038/s41598-018-24226-0 　

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Poor sleep quality is associated with unfavorable psychological measurements, whereas sleep duration has complex relationships with such measurements. The aim of this study was to identify the associations between microstructural properties of the brain and sleep duration/sleep quality in a young adult. The associations between mean diffusivity (MD), a measure of diffusion tensor imaging (DTI), and sleep duration/sleep quality were investigated in a study cohort of 1201 normal young adults. Positive correlations between sleep duration and MD of widespread areas of the brain, including the prefrontal cortex (PFC) and the dopaminergic systems, were identified. Negative correlations between sleep quality and MD of the widespread areas of the brain, including the PFC and the right hippocampus, were also detected. Lower MD has been previously associated with more neural tissues in the brain. Further, shorter sleep duration was associated with greater persistence and executive functioning (lower Stroop interference), whereas good sleep quality was associated with states and traits relevant to positive affects. These results suggest that bad sleep quality and longer sleep duration were associated with aberrant neurocognitive measurements in the brain in healthy young adults.
REDUCED FUNCTIONAL CONNECTIVITY BETWEEN THE RIGHT VENTRAL ACC AND MFG PREDICTS PTSD SYMPTOMS AFTER A DISASTER 査読有り

Sekiguchi Atsushi, Kotozaki Yuka, Sugiura Motoaki, Nakagawa Seishu, Nouchi Rui, Miyauchi Carlos M, Takeuchi Hikaru, Taki Yasuyuki, Kawashima Ryuta

PSYCHOSOMATIC MEDICINE　80　(3)　A72-A73　2018年4月

ISSN：0033-3174
Allergic tendencies are associated with larger gray matter volumes. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Scientific reports　8　(1)　3694-3694　2018年2月27日

DOI： 10.1038/s41598-018-21985-8 　

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Allergic tendencies are associated with important cognitive and physiological factors, such as intelligence and mathematical abilities. Allergies are widely prevalent, especially in modern life, and the reason for its association with important cognitive variables is an intriguing scientific question. However, despite the unique characteristics of cognitive correlates of allergy, the anatomical correlates of allergy remain unknown. The aim of this study was to identify the associations between regional gray matter volume (rGMV) and allergic tendencies in young adults. In a study cohort of 1,219 healthy, educated young adults, we identified a positive correlation between total allergic tendency and rGMV in large anatomical clusters that mainly encompassed the dorsal part of the cerebral neocortex, right anterior insula, and cerebellum. Furthermore,both mean rGMV of the entire part of these clusters and total allergenic tendency showed a significant positive correlation with spatial ability. These results suggest the link among allergic tendencies, larger rGMV, and the better spatial ability in healthy, educated young adults.
Refractive error is associated with intracranial volume. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Scientific reports　8　(1)　175-175　2018年1月9日

DOI： 10.1038/s41598-017-18669-0 　

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Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.
Structural studies of creativity measured by divergent thinking 査読有り

Hikaru Takeuchi, Ryuta Kawashima

The Cambridge Handbook of the Neuroscience of Creativity　451-463　2018年1月1日
出版者・発行元： Cambridge University Press
DOI： 10.1017/9781316556238.026 　
Intra-individual cognitive imbalance in ASD between perceptual reasoning and ambiguity-solving related to tool use: Comparison among children exhibiting ASD, AD/HD, and typical development 査読有り

Keisuke Wakusawa, Chieko Nara, Yuki Kubota, Yayoi Tomizawa, Yasuyuki Taki, Yuko Sassa, Satoru Kobayashi, Sato Suzuki-Muromoto, Mieko Hirose, Hiroyuki Yokoyama, Takahiro Nara, Shigeo Kure, Norio Mori, Noriyoshi Takei, Ryuta Kawashima

Brain and Development　40　(1)　16-25　2018年1月1日
出版者・発行元： Elsevier B.V.
DOI： 10.1016/j.braindev.2017.07.002 　

ISSN：1872-7131 0387-7604

eISSN：1872-7131
The Beneficial Effects of Cognitive Training With Simple Calculation and Reading Aloud (SCRA) in the Elderly Postoperative Population: A Pilot Randomized Controlled Trial. 国際誌

Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima

Frontiers in aging neuroscience　10　68-68　2018年

DOI： 10.3389/fnagi.2018.00068 　

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Background: There has been little research conducted regarding cognitive treatments for the elderly postsurgical population. Patients aged ≥60 years have an increased risk of postoperative cognitive decline, a condition in which cognitive functions are negatively affected. This cognitive decline can lead to a decline in quality of life. In order to maintain a high quality of life, the elderly postsurgical population may benefit from treatment to maintain and/or improve their cognitive functions. This pilot study investigates the effect of simple calculation and reading aloud (SCRA) cognitive training in elderly Japanese postsurgical patients. Methods: Elderly patients undergoing non-cardiovascular thoracic surgery under general anesthesia were recruited (n = 12). Subjects were randomly divided into two groups-one that receives 12 weeks of SCRA intervention, and a waitlisted control group. Before and after the intervention, we measured cognitive function [Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), computerized Cogstate Brief Battery (CBB)] and emotional state [General Health Questionnaire-12 (GHQ-12), Geriatric Depression Scale (GDS), Quality of Life Scale-5 (QOL-5)]. Results: Group difference analyses using ANCOVA with permutation test showed that the intervention SCRA group had a significant improvement in FAB motor programming sub-score, GDS, and QOL-5 compared to the control group. Within-group analyses using Wilcoxon signed-rank test to compare baseline and follow-up showed that the SCRA intervention group total FAB scores, FAB motor programming sub-scores, and QOL-5 scores were significantly improved. Discussion: This pilot study showed that there are important implications for the beneficial effects of SCRA intervention on cognitive function and emotional state in the postoperative elderly population; however, further investigations are necessary to reach any conclusions. Trial registration: This study was registered with the University Hospital Medical Information Network (UMIN) Clinical Trial Registry (UMIN000019832).
The paradox of warmth: Ambient warm temperature decreases preference for savory foods 査読有り

Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

Food Quality and Preference　69　1-9　2018年

DOI： 10.1016/j.foodqual.2018.04.006 　

ISSN：0950-3293
Tastiness but not healthfulness captures automatic visual attention: Preliminary evidence from an eye-tracking study 査読有り

Motoki Kosuke, Saito Toshiki, Nouchi Rui, Sugiura Motoaki, Kawashima Ryuta, ual contribu

Food Quality and Preference　64　148-153　2018年

DOI： 10.1016/j.foodqual.2017.09.014 　

ISSN：0950-3293
The Effects of Family Socioeconomic Status on Psychological and Neural Mechanisms as Well as Their Sex Differences. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoishi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Frontiers in human neuroscience　12　543-543　2018年

DOI： 10.3389/fnhum.2018.00543 　

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Family socioeconomic status (SES) is an important factor that affects an individual's neural and cognitive development. The two novel aims of this study were to reveal (a) the effects of family SES on mean diffusivity (MD) using diffusion tensor imaging given the characteristic property of MD to reflect neural plasticity and development and (b) the sex differences in SES effects. In a study cohort of 1,216 normal young adults, we failed to find significant main effects of family SES on MD; however, previously observed main effects of family SES on regional gray matter volume and fractional anisotropy (FA) were partly replicated. We found a significant effect of the interaction between sex and family income on MD in the thalamus as well as significant effects of the interaction between sex and parents' educational qualification (year's of education) on MD and FA in the body of the corpus callosum as well as white matter areas between the anterior cingulate cortex and lateral prefrontal cortex. These results suggest the sex-specific associations of family SES with neural and/or cognitive mechanisms particularly in neural tissues in brain areas that play key roles in basic information processing and higher-order cognitive processes in a way females with greater family SES level show imaging outcome measures that have been associated with more neural tissues (such as greater FA and lower MD) and males showed opposite.
Effects of Time-Compressed Speech Training on Multiple Functional and Structural Neural Mechanisms Involving the Left Superior Temporal Gyrus. 国際誌査読有り

Tsukasa Maruyama, Hikaru Takeuchi, Yasuyuki Taki, Kosuke Motoki, Hyeonjeong Jeong, Yuka Kotozaki, Seishu Nakagawa, Rui Nouchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Kohei Sakaki, Yukako Sasaki, Daniele Magistro, Ryuta Kawashima

Neural plasticity　2018　6574178-6574178　2018年

DOI： 10.1155/2018/6574178 　

ISSN：2090-5904

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Time-compressed speech is an artificial form of rapidly presented speech. Training with time-compressed speech (TCSSL) in a second language leads to adaptation toward TCSSL. Here, we newly investigated the effects of 4 weeks of training with TCSSL on diverse cognitive functions and neural systems using the fractional amplitude of spontaneous low-frequency fluctuations (fALFF), resting-state functional connectivity (RSFC) with the left superior temporal gyrus (STG), fractional anisotropy (FA), and regional gray matter volume (rGMV) of young adults by magnetic resonance imaging. There were no significant differences in change of performance of measures of cognitive functions or second language skills after training with TCSSL compared with that of the active control group. However, compared with the active control group, training with TCSSL was associated with increased fALFF, RSFC, and FA and decreased rGMV involving areas in the left STG. These results lacked evidence of a far transfer effect of time-compressed speech training on a wide range of cognitive functions and second language skills in young adults. However, these results demonstrated effects of time-compressed speech training on gray and white matter structures as well as on resting-state intrinsic activity and connectivity involving the left STG, which plays a key role in listening comprehension.
Benefits of "smart ageing" interventions using cognitive training, brain training games, exercise, and nutrition intake for aged memory functions in healthy elderly people 査読有り

Rui Nouchi, Ryuta Kawashima

Memory in a Social Context: Brain, Mind, and Society　269-280　2017年12月15日
出版者・発行元： Springer Japan
DOI： 10.1007/978-4-431-56591-8_15 　
Eyewear Equipped with a Triaxial Accelerometer Detects Age-Related Changes in Ambulatory Activity 招待有り査読有り

Shigeyuki Ikeda, Susumu Ichinohe, Ryuta Kawashima

DigitCult - Scientific Journal on Digital Cultures　2　(2)　1-8　2017年11月

DOI： 10.4399/97888255088951 　
Neural correlates of ambient thermal sensation: An fMRI study 査読有り

Hajime Oi, Teruo Hashimoto, Takayuki Nozawa, Akitake Kanno, Natasha Kawata, Kanan Hirano, Yuki Yamamoto, Motoaki Sugiura, Ryuta Kawashima

SCIENTIFIC REPORTS　7　2017年9月

DOI： 10.1038/s41598-017-11802-z 　

ISSN：2045-2322
Lenticular nucleus correlates of general self-efficacy in young adults. 国際誌査読有り

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Brain structure & function　222　(7)　3309-3318　2017年9月

DOI： 10.1007/s00429-017-1406-2 　

ISSN：1863-2653

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General self-efficacy (GSE) is an important factor in education, social participation, and medical treatment. However, the only study that has investigated the direct association between GSE and a neural correlate did not identify specific brain regions, rather only assessed brain structures, and included older adult subjects. GSE is related to motivation, physical activity, learning, the willingness to initiate behaviour and expend effort, and adjustment. Thus, it was hypothesized in the present study that the neural correlates of GSE might be related to changes in the basal ganglia, which is a region related to the abovementioned self-efficacy factors. This study aimed to identify the brain structures associated with GSE in healthy young adults (n = 1204, 691 males and 513 females, age 20.7 ± 1.8 years) using regional grey matter density and volume (rGMD and rGMV), fractional anisotropy (FA) and mean diffusivity (MD) analyses of magnetic resonance imaging (MRI) data. The findings showed that scores on the GSE Scale (GSES) were associated with a lower MD value in regions from the right putamen to the globus pallidum; however, there were no significant association between GSES scores and regional brain structures using the other analyses (rGMD, rGMV, and FA). Thus, the present findings indicated that the lenticular nucleus is a neural correlate of GSE.
Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Scientific reports　7　(1)　10014-10014　2017年8月30日

DOI： 10.1038/s41598-017-10104-8 　

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Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on the available evidence, we hypothesized that diverse CCAs are all positively but only weakly associated with rGMV in widespread brain areas. To test this hypothesis, we used the data from a large sample of healthy young adults [776 males and 560 females; mean age: 20.8 years, standard deviation (SD) = 0.8] and investigated associations between rGMV and scores on multiple CCA tasks (including non-verbal reasoning, verbal working memory, Stroop interference, and complex processing speed tasks involving spatial cognition and reasoning). Better performance scores on all tasks except non-verbal reasoning were associated with greater rGMV across widespread brain areas. The effect sizes of individual associations were generally low, consistent with our previous studies. The lack of strong correlations between rGMV and specific CCAs, combined with stringent corrections for multiple comparisons, may lead to different and diverse findings in the field.
Gaze Bias in Preference Judgments by Younger and Older Adults 国際誌査読有り

Saito Toshiki, Nouchi Rui, Kinjo Hikari, Kawashima Ryuta

Frontiers in Aging Neuroscience　9　285-285　2017年8月

DOI： 10.3389/fnagi.2017.00285 　

ISSN：1663-4365
Noninvasive stroke volume variation using electrical velocimetry for predicting fluid responsiveness in dogs undergoing cardiac surgery 査読有り

Kazumasu Sasaki, Tatsushi Mutoh, Tomoko Mutoh, Yasuyuki Taki, Ryuta Kawashima

Veterinary Anaesthesia and Analgesia　44　(4)　719-726　2017年7月1日
出版者・発行元： Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia
DOI： 10.1016/j.vaa.2016.11.001 　

ISSN：1467-2995 1467-2987
Neural Mechanisms Underlying the Reward-Related Enhancement of Motivation When Remembering Episodic Memories With High Difficulty 査読有り

Yayoi Shigemune, Takashi Tsukiura, Rui Nouchi, Toshimune Kambara, Ryuta Kawashima

HUMAN BRAIN MAPPING　38　(7)　3428-3443　2017年7月

DOI： 10.1002/hbm.23599 　

ISSN：1065-9471

eISSN：1097-0193
The VEGF gene polymorphism impacts brain volume and arterial blood volume. 国際誌査読有り

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Human brain mapping　38　(7)　3516-3526　2017年7月

DOI： 10.1002/hbm.23606 　

ISSN：1065-9471

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Vascular endothelial growth factor (VEGF) plays a critical role in the angiogenesis and proliferation of various types of cells such as neurons, astroglia, and endothelial cells in the brain. A common polymorphism in the VEGF gene (-2578 C/A) is associated with circulating VEGF levels, cancers and Alzheimer's disease. Nonetheless, the effects of this polymorphism on normal human brain volume, arterial blood volume, and blood supply remain unclear. In this study, the effects of this polymorphism on the total gray matter volume (TGMV) and total white matter volume (TWMV) using T1-weighted structural images and the total arterial blood volume (TABV) and mean cerebral blood flow (mCBF) during rest using arterial spin labeling (ASL) in 765 young adult humans were investigated. Voxel-by-voxel whole-brain analyses of these measures were also performed. Multiple regression analyses with age and sex as covariates revealed that the VEGF genotype (number of C alleles) was significantly and positively correlated with TGMV, TWMV, and TABV as well as with regional gray and white matter volumes in widespread areas and regional arterial blood volume in some areas with high arterial blood volume. However, these regional associations were not seen when the corresponding global signal was included as a covariate in the multiple regression analyses, indicating that we failed to obtain evidence of region-specific associations between these brain measures and the genotype. The results suggest that the VEGF-2578C allele, is associated with changes in the vascular system that lead to increased blood volume and larger brain volume. Hum Brain Mapp 38:3516-3526, 2017. © 2017 Wiley Periodicals, Inc.
Neural correlates of bilingual language control during interlingual homograph processing in a logogram writing system 査読有り

Hsieh MH, Jeong H, Kawata KH, Sasaki Y, Lee HC, Yokoyama S, Sugiura M, Kawashima R

Brain and Language　174　72-85　2017年7月

DOI： 10.1016/j.bandl.2017.06.006 　

ISSN：0093-934X

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Bilingual studies using alphabetic languages have shown parallel activation of two languages during word recognition. However, little is known about the brain mechanisms of language control during word comprehension with a logogram writing system. We manipulated the types of words (interlingual homographs (IH), cognates, and language-specific words) and the types of participants (Chinese (L1)-Japanese (L2) bilinguals vs. Japanese monolinguals). Greater activation was found in the bilateral inferior frontal gyri, supplementary motor area, caudate nucleus and left fusiform gyrus, when the bilinguals processed IH, as compared to cognates. These areas were also commonly activated when the bilinguals processed L2 control words during an L1 lexical decision task. The areas function as the task/decision system that plays a role in cognitive control for resolving response conflict. Furthermore, the anterior cingulate cortex, left thalamus, and left middle temporal gyrus were activated during IH processing, suggesting resolution of the semantic conflict at the stimulus level (i.e., one logographic word having different meanings in the two languages).
グリア線維酸性蛋白質遺伝子多型の脳構造への影響の検討精神疾患感受性メカニズムの理解に向けて

高橋雄太, 伊藤文晃, 竹内光, 坂井舞, 兪志前, 松岡洋夫, 瀧靖之, 川島隆太, 富田博秋

精神神経学雑誌　(2017特別号)　S622-S622　2017年6月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
EXPERIMENTAL STUDY ON TEAM COORDINATION OF NPP PLANT OPERATORS BASED ON THE SIMULTANEOUS NIRS MEASUREMENTS 査読有り

Makoto Takahashi, Fumiyasu Shirai, Ryuta Kawashima, Kazukiyo Ueda

Transactions of the American Nuclear Society　116　1226-1233　2017年6月
Evaluating age-related change in lip somatosensation using somatosensory evoked magnetic fields 査読有り

Hiroki Hihara, Hiroyasu Kanetaka, Akitake Kanno, Satoko Koeda, Nobukazu Nakasato, Ryuta Kawashima, Keiichi Sasaki

PLOS ONE　12　(6)　e0179323　2017年6月

DOI： 10.1371/journal.pone.0179323 　

ISSN：1932-6203
Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

NeuroImage　152　258-269　2017年5月15日

DOI： 10.1016/j.neuroimage.2017.02.079 　

ISSN：1053-8119

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Brain connectivity is traditionally thought to be important for creativity. Here we investigated the associations of creativity measured by divergent thinking (CMDT) with resting-state functional magnetic imaging (fMRI) measures and their sex differences. We examined these relationships in the brains of 1277 healthy young adults. Whole-brain analyses revealed a significant interaction between verbal CMDT and sex on (a) regional homogeneity within an area from the left anterior temporal lobe (b) on the resting state functional connectivity (RSFC) between the mPFC and the left inferior frontal gyrus and (c) on fractional amplitude of low frequency fluctuations (fALFF) in several distinct areas, including the precuneus and middle cingulate gyrus, left middle temporal gyrus, right middle frontal gyrus, and cerebellum. These interactions were mediated by positive correlations in females and negative correlations in males. These findings suggest that greater CMDT in females is reflected by (a) regional coherence (regional homogeneity) of brain areas responsible for representing and combining concepts as well as (b) the efficient functional connection (RSFC) between the key areas for the default state of cognitive activity and speech production, and (c) greater spontaneous neural activity (fALFF) during the resting of brain areas involved in frontal lobe functions, default cognitive activities, and language functions. Furthermore, these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females.
Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Scientific reports　7　(1)　1470-1470　2017年5月3日

DOI： 10.1038/s41598-017-01460-6 　

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Working memory training (WMT) induces changes in cognitive function and various neurological systems. Here, we investigated changes in recently developed resting state functional magnetic resonance imaging measures of global information processing [degree of the cortical hub, which may have a central role in information integration in the brain, degree centrality (DC)], the magnitude of intrinsic brain activity [fractional amplitude of low frequency fluctuation (fALFF)], and local connectivity (regional homogeneity) in young adults, who either underwent WMT or received no intervention for 4 weeks. Compared with no intervention, WMT increased DC in the anatomical cluster, including anterior cingulate cortex (ACC), to the medial prefrontal cortex (mPFC). Furthermore, WMT increased fALFF in the anatomical cluster including the right dorsolateral prefrontal cortex (DLPFC), frontopolar area and mPFC. WMT increased regional homogeneity in the anatomical cluster that spread from the precuneus to posterior cingulate cortex and posterior parietal cortex. These results suggest WMT-induced plasticity in spontaneous brain activity and global and local information processing in areas of the major networks of the brain during rest.
Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models 査読有り

Shogo Ogita, Toshiki Endo, Shinichiro Sugiyama, Ryuta Saito, Tomoo Inoue, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Yukihiko Sonoda, Teiji Tominaga

ACTA NEUROCHIRURGICA　159　(5)　939-946　2017年5月

DOI： 10.1007/s00701-017-3123-2 　

ISSN：0001-6268

eISSN：0942-0940
Structural brain development in healthy children and adolescents 査読有り

Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki

Brain and Nerve　69　(5)　539-545　2017年5月1日
出版者・発行元： Igaku-Shoin Ltd
ISSN：1881-6096
健常小児の脳の形態的発達

松平泉, 瀧靖之, 川島隆太

BRAIN and NERVE　69　(5)　539-545　2017年5月
Sexual differentiation of the adolescent rat brain: A longitudinal voxel-based morphometry study. 国際誌査読有り

Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima

Neuroscience letters　642　168-173　2017年3月6日

DOI： 10.1016/j.neulet.2016.12.023 　

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The sexual differentiation of the rat brain during the adolescent period has been well documented in post-mortem histological studies. However, to further understand the morphological changes occurring in the entire brain, a noninvasive neuroimaging method allowing an unbiased, comprehensive, and longitudinal investigation of brain morphology should be used. In this study, we investigated the sexual differentiation of the rat brain during the adolescent period using longitudinal voxel-based morphometry (VBM) analysis. Male and female Wistar rats (n=12 of each) were scanned in a 7.0-T MRI scanner at five time points from 6 to 10 weeks of age. The T2-weighted MRI images were segmented using the rat brain tissue priors that have been published by our laboratory. At the global level, the results of the VBM analysis showed greater increases in total gray matter volume in the males during the adolescent period, although we did not find significant differences in total white matter volume. At the voxel level, we found significant increases in the regional gray matter volume of the occipital cortex, amygdala, hippocampal formation, and cerebellum. At the regional level, only the occipital cortex in the females exhibited decreases during the adolescent period. These results were, at least in part, consistent with those of previous longitudinal VBM studies in humans, thus providing translational evidence of the sexual differentiation of the developing brain between rodents and humans.
INSTRUCTIONAL SCAFFOLDING IN A UNIVERSITY EFL COURSE IN JAPAN: TOWARD THE INVESTIGATION OF STUDENTS’ FLOW IN A CLASSROOM

Mutsumi Kondo, Takayuki Nozawa, Hyeonjeong Jeong, Shigeyuki Ikeda, Kohei Sakaki, Ryuta Kawashima, Reiko Yamamoto, Yasushige Ishikawa

INTED2017 Proceedings　2017年3月
出版者・発行元： IATED
DOI： 10.21125/inted.2017.1742 　
Social Interaction Affects Neural Outcomes of Sign Language Learning As a Foreign Language in Adults 査読有り

Noriaki Yusa, Jungho Kim, Masatoshi Koizumi, Motoaki Sugiura, Ryuta Kawashima

FRONTIERS IN HUMAN NEUROSCIENCE　11　2017年3月

DOI： 10.3389/fnhum.2017.00115 　

ISSN：1662-5161
Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states. 国際誌査読有り

Takeuchi H, Taki Y, Sekiguchi A, Nouchi R, Kotozaki Y, Nakagawa S, Miyauchi CM, Iizuka K, Yokoyama R, Shinada T, Yamamoto Y, Hanawa S, Araki T, Kunitoki K, Sassa Y, Kawashima R

Brain structure & function　222　(2)　1027-1037　2017年3月

DOI： 10.1007/s00429-016-1262-5 　

ISSN：1863-2653
呈示された音の高さに合わせた発声中における皮質活動時間-周波数分析を用いた脳磁図の研究(Cortical activity during vocalization tuned to the pitch of the presented sound: magnetoencephalographic study using time-frequency analysis)

Nomura Yuri, Kawase Tetsuaki, Kanno Akitake, Nakasato Nobukazu, Kawashima Ryuta, Katori Yukio

日本生体磁気学会誌　30　(1)　67-67　2017年
出版者・発行元：日本生体磁気学会
ISSN：0915-0374
歯周靱帯に対する体性感覚刺激により惹起される磁界(Somatosensory evoked magnetic fields for the periodontal ligaments)

Hihara Hiroki, Kanetaka Hiroyasu, Kanno Akitake, Nakasato Nobukazu, Kawashima Ryuta, Sasaki Keiichi

日本生体磁気学会誌　30　(1)　76-76　2017年
出版者・発行元：日本生体磁気学会
ISSN：0915-0374
脳皮質における歯周靱帯刺激に対する体性感覚の応答(Somatosensory evoked responses in the cerebral cortex to periodontal ligament stimulation)

Shimada Eriya, Kanetaka Hiroyasu, Kanno Akitake, Kawashima Ryuta, Nakasato Nobukazu, Igarashi Kaoru

日本生体磁気学会誌　30　(1)　77-77　2017年
出版者・発行元：日本生体磁気学会
ISSN：0915-0374
脳磁計で特異的に検出された前臨床状態のてんかんの1症例(A case of subclinical seizures uniquely detected by magnetoencephalography)

Ishida Makoto, Kanno Akitake, Kakisaka Yosuke, Iwasaki Masaki, Jin Kazutaka, Kitazawa Yu, Kawashima Ryuta, Nakasato Nobukazu

日本生体磁気学会誌　30　(1)　79-79　2017年
出版者・発行元：日本生体磁気学会
ISSN：0915-0374
Electrical velocimetry for noninvasive cardiac output and stroke volume variation measurements in dogs undergoing cardiovascular surgery 査読有り

Kazumasu Sasaki, Tatsushi Mutoh, Tomoko Mutoh, Ryuta Kawashima, Hirokazu Tsubonez

VETERINARY ANAESTHESIA AND ANALGESIA　44　(1)　7-16　2017年1月

DOI： 10.1111/vaa.12380 　

ISSN：1467-2987

eISSN：1467-2995
Indication of Cognitive Change and Associated Risk Factor after Thoracic Surgery in the Elderly: A Pilot Study. 国際誌

Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima

Frontiers in aging neuroscience　9　396-396　2017年

DOI： 10.3389/fnagi.2017.00396 　

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Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery is aging. Methods: Cognitive function was measured for all subjects (n = 12) before and after surgery using three different cognitive tests: Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), and a computerized Cogstate Brief Battery (CBB). Changes in these measures indicate changes in cognitive function. In addition, the 12-item General Health Questionnaire (GHQ-12), the Geriatric Depression Scale (GDS), and the 5-item Quality of Life questionnaire (QOL-5) were administered at each time point to measure mental and emotional state. Changes in outcome measures were analyzed via Wilcoxon signed-rank test. Exploratory correlation analysis was conducted using Spearman's rho. Results: Data show a decline in detection (DET; p = 0.045) and identification (IDN; p = 0.038). Spearman's correlation coefficient show a significant correlation between postoperative DET scores and postoperative IDN scores (ρ = 0.78, p = 0.005), a significant correlation between change in IDN and baseline GHQ-12 scores (ρ = -0.595, p = 0.027), and a significant correlation between change in one-back (OBK) scores and duration of anesthesia (ρ = -0.72, p = 0.012). Discussion: This was the first report to examine cognitive decline after major thoracic surgery in Japanese patients. Previous studies have evidenced that POCD is a common phenomenon after surgery, and that age is a major risk factor. The CCB measured significant change in two cognitive domains: attention and psycomotor function. This study clarified that decline in cognition is detectable in certain measures after thoracic surgery in the elderly Japanese patient population. Additionally, longer anesthetic exposure may negatively impact attention and working memory, and preoperative mental wellbeing is a possible predictor of POCD. These preliminary results have important implications and support the need for future studies.
Steady beat sound facilitates both coordinated group walking and inter-subject neural synchrony 査読有り

Shigeyuki Ikeda, Takayuki Nozawa, Ryoichi Yokoyama, Atsuko Miyazaki, Yukako Sasaki, Kohei Sakaki, Ryuta Kawashima

Frontiers in Human Neuroscience　11　147　2017年
出版者・発行元：
DOI： 10.3389/fnhum.2017.00147 　

eISSN：1662-5161
VBMと認知機能(総説) 招待有り

竹内光, 川島隆太

脳と神経　in press　2017年
Neural bases of the adaptive mechanisms associated with reciprocal partner choice 査読有り

Ryoichi Yokoyama, Motoaki Sugiura, Yuki Yamamoto, Keyvan Kashkouli Nejad, Ryuta Kawashima

NEUROIMAGE　145　74-81　2017年1月

DOI： 10.1016/j.neuroimage.2016.09.052 　

ISSN：1053-8119

eISSN：1095-9572
Effects of Visual Speech on Early Auditory Evoked Fields - From the Viewpoint of Individual Variance 査読有り

Izumi Yahata, Tetsuaki Kawase, Akitake Kanno, Hiroshi Hidaka, Shuichi Sakamoto, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

PLOS ONE　12　(1)　e0170166　2017年1月

DOI： 10.1371/journal.pone.0170166 　

ISSN：1932-6203
The anterior midcingulate cortex as a neural node underlying hostility in young adults. 国際誌査読有り

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Brain structure & function　222　(1)　61-70　2017年1月

DOI： 10.1007/s00429-016-1200-6 　

ISSN：1863-2661 1863-2653

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Anger typically manifests for only a short period of time, whereas hostility is present for a longer duration. However, both of these emotions are associated with an increased likelihood of psychological problems. The nodes within the neural networks that underlie hostility remain unclear. We presumed that specific nodes might include the anterior midcingulate cortex (aMCC), which seems to be essential for the cognitive aspects of hostility. Thus, the present study first evaluated the associations between regional gray matter density (rGMD) and hostility in 777 healthy young students (433 men and 344 women; 20.7 ± 1.8 years of age) using magnetic resonance imaging and the hostile behaviors subscale (HBS) of the Coronary-prone Type Scale (CTS) for Japanese populations. The HBS scores were positively correlated with rGMD in the aMCC and in widespread frontal regions from the dorsomedial/dorsolateral prefrontal cortices to the lateral premotor cortex at the whole-brain level. No significant correlation was observed between rGMD and the conjunction of HBS and Trait Anger/Anger-Out scores. Furthermore, no significant interaction effects of sex and HBS scores on rGMD were revealed, although the HBS scores of males were significantly higher than those of females. The present findings indicate that the neural correlates of hostility appear to be more distinct in rGMD than those of anger due to differences and duration.
Creative females have larger white matter structures: Evidence from a large sample study. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Human brain mapping　38　(1)　414-430　2017年1月

DOI： 10.1002/hbm.23369 　

ISSN：1065-9471

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The importance of brain connectivity for creativity has been theoretically suggested and empirically demonstrated. Studies have shown sex differences in creativity measured by divergent thinking (CMDT) as well as sex differences in the structural correlates of CMDT. However, the relationships between regional white matter volume (rWMV) and CMDT and associated sex differences have never been directly investigated. In addition, structural studies have shown poor replicability and inaccuracy of multiple comparisons over the whole brain. To address these issues, we used the data from a large sample of healthy young adults (776 males and 560 females; mean age: 20.8 years, SD = 0.8). We investigated the relationship between CMDT and WMV using the newest version of voxel-based morphometry (VBM). We corrected for multiple comparisons over whole brain using the permutation-based method, which is known to be quite accurate and robust. Significant positive correlations between rWMV and CMDT scores were observed in widespread areas below the neocortex specifically in females. These associations with CMDT were not observed in analyses of fractional anisotropy using diffusion tensor imaging. Using rigorous methods, our findings further supported the importance of brain connectivity for creativity as well as its female-specific association. Hum Brain Mapp 38:414-430, 2017. © 2016 Wiley Periodicals, Inc.
A Comprehensive Analysis of the Correlations between Resting-State Oscillations in Multiple-Frequency Bands and Big Five Traits. 国際誌査読有り

Shigeyuki Ikeda, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

Frontiers in human neuroscience　11　321-321　2017年

DOI： 10.3389/fnhum.2017.00321 　

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Recently, the association between human personality traits and resting-state brain activity has gained interest in neuroimaging studies. However, it remains unclear if Big Five personality traits are represented in frequency bands (~0.25 Hz) of resting-state functional magnetic resonance imaging (fMRI) activity. Based on earlier neurophysiological studies, we investigated the correlation between the five personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI), and the fractional amplitude of low-frequency fluctuation (fALFF) at four distinct frequency bands (slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.073 Hz), slow-3 (0.073-0.198 Hz) and slow-2 (0.198-0.25 Hz)). We enrolled 835 young subjects and calculated the correlations of resting-state fMRI signals using a multiple regression analysis. We found a significant and consistent correlation between fALFF and the personality trait of extraversion at all frequency bands. Furthermore, significant correlations were detected in distinct brain regions for each frequency band. This finding supports the frequency-specific spatial representations of personality traits as previously suggested. In conclusion, our data highlight an association between human personality traits and fALFF at four distinct frequency bands.
Impact of Audio-Visual Asynchrony on Lip-Reading Effects -Neuromagnetic and Psychophysical Study- 査読有り

Tetsuaki Kawase, Izumi Yahata, Akitake Kanno, Shuichi Sakamoto, Yoshitaka Takanashi, Shiho Takata, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

PLOS ONE　11　(12)　e0168740　2016年12月

DOI： 10.1371/journal.pone.0168740 　

ISSN：1932-6203
Impact of videogame play on the brain’s microstructural properties: Cross-sectional and longitudinal analyses 査読有り

Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R

Molecular Psychiatry　21　(12)　1781-1789　2016年12月

DOI： 10.1038/mp.2015.193 　
Postoperative hormonal therapy prevents recovery of neurological damage after surgery in patients with breast cancer. 国際誌査読有り

Atsushi Sekiguchi, Chiho Sato, Izumi Matsudaira, Yuka Kotozaki, Rui Nouchi, Hikaru Takeuchi, Masaaki Kawai, Hiroshi Tada, Takanori Ishida, Yasuyuki Taki, Noriaki Ohuchi, Ryuta Kawashima

Scientific reports　6　34671-34671　2016年10月6日

DOI： 10.1038/srep34671 　

ISSN：2045-2322

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Cancer survivors are exposed to several risk factors for cognitive dysfunction, such as general anesthesia, surgical trauma, and adjuvant therapies. In our recent study we showed that thalamic volume reduction and attentional dysfunction occurred shortly after surgery. Here, we examined the 6-month prognosis of the 20 patients with breast cancer who underwent surgery. Seven patients did not receive any adjuvant therapy after the surgery and 13 patients received a hormonal therapy after the surgery. We assessed their attentional functions, and thalamic volumes shortly after and 6 months after surgery. We found a significant group x time interaction in the attentional functions (p = 0.033) and the right thalamus (p < 0.05, small volume correction), suggesting the thalamic volume reduction and attentional dysfunction recovered in patients without adjuvant therapy. Our findings provide a better understanding of the potential role of hormonal therapy in relation to the cognitive dysfunction of cancer survivors.
Convection-enhanced delivery of SN-38-loaded polymeric micelles (NK012) enables consistent distribution of SN-38 and is effective against rodent intracranial brain tumor models 査読有り

Rong Zhang, Ryuta Saito, Yui Mano, Akira Sumiyoshi, Masayuki Kanamori, Yukihiko Sonoda, Ryuta Kawashima, Teiji Tominaga

DRUG DELIVERY　23　(8)　2780-2786　2016年10月

DOI： 10.3109/10717544.2015.1081994 　

ISSN：1071-7544

eISSN：1521-0464
Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster. 国際誌査読有り

Seishu Nakagawa, Motoaki Sugiura, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Sugiko Hanawa, Tsuyoshi Araki, Hikaru Takeuchi, Atsushi Sakuma, Yasuyuki Taki, Ryuta Kawashima

Scientific reports　6　34364-34364　2016年9月27日

DOI： 10.1038/srep34364 　

ISSN：2045-2322

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The relating to others factor of post-traumatic growth (PTG), which involves mutual help and a strong sense of connection with humanity, is important for young people who are coping with stress. The prefrontal cortex (PFC), especially the dorsolateral PFC (DLPFC), may play an important role in post-traumatic stress disorder (PTSD) with regard to coping and resilience. We hypothesized that the neural correlates of PTG may be responsible for resilience to the correlates of PTSD. Our study tested this hypothesis by examining whether measures of PTG, particularly the measures of relating to others after a disaster, were associated with increased regional grey matter volume (rGMV) in the PFC by assessing individuals who had experienced the East Japan Great Earthquake. We calculated the delta-rGMV by subtracting the rGMV obtained 3 months before the disaster from the rGMV obtained after this disaster using voxel-based morphometry. The magnetic resonance imaging data obtained from 26 subjects (M/F: 21/5; age: 21.2 ± 1.6 yrs.) showed that the total scores on a PTG inventory and the subscore for relating to others at the post-assessment were positively and significantly associated with the delta-rGMV in the right DLPFC. The DLPFC seems to be the main neural correlate of PTG.
Neuroanatomical bases of effortful control: evidence from a large sample of young healthy adults using voxel-based morphometry. 国際誌査読有り

Rui Nouchi, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Yuko Sassa, Ryuta Kawashima

Scientific reports　6　31231-31231　2016年8月9日

DOI： 10.1038/srep31231 　

ISSN：2045-2322

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Effortful control (EC) is a base of individuality in cognition and psychological adjustment. EC is defined as a capacity to control responses and behaviors. We investigated associations between individual differences of EC and regional gray and white matter volume (rGMV/rGMV) in 374 men and 306 women (age, 20.61 ± 1.82 years) using Japanese version of Effortful control scale (J-ECS). J-ECS consists of three subscales such as inhibitory control (IC), activation control (ACTC), and attentional control (ATC). Results showed that (a) IC was associated with larger rGMV in the dorsal part of anterior cingulate cortex (dACC), the supplementary motor area (SMA) and the pre SMA and larger rWMV in the dACC, (b) ACTC was correlated with smaller rGMV in the insula and the putamen, and (c) ATC was associated with larger rWMV in the inferior frontal gyrus, orbital frontal gyrus, ACC, and insula. Our study revealed key neuroanatomical correlations between EC and rGMV and rWMV.
The beneficial effects of cognitive training with simple calculation and reading aloud in an elderly postsurgical population: study protocol for a randomized controlled trial. 国際誌

Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima

Trials　17　334-334　2016年7月22日

DOI： 10.1186/s13063-016-1476-0 　

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BACKGROUND: This project proposes a pilot study to investigate the positive healing effects of cognitive training with simple arithmetic and reading aloud on elderly postsurgical patients. Elderly patients undergoing surgery have an increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery has aged. Little effort has been expended, however, to find treatments for POCD. Learning therapy, which consists of a combination of reading aloud and solving simple arithmetic problems, was developed in Japan as a treatment for Alzheimer's Disease to improve cognitive functions. Because patients with Alzheimer's Disease experience similar issues as those with POCD in learning, memory, and processing speed, a cognitive intervention based on the learning-therapy treatments used for Alzheimer's Disease could show advantageous outcomes for those at risk of POCD. METHODS/DESIGN: Cognitive function will be measured before and after surgery using three different tests (Mini-Mental Status Exam, Frontal Assessment Battery, and Cogstate computerized tests). Subjects will be randomly divided into two groups-one that receives a Simple Calculation and Reading Aloud intervention (SCRA) and a waitlisted control group that does not receive SCRA. To measure cognition before and after the intervention, the previously mentioned three tests will be used. The obtained data will be analyzed using statistical tests such as ANCOVA to indicate whether the cognitive intervention group has made improvements in their cognitive functions. In addition, questionnaires will also be administered to collect data on mental and emotional statuses. DISCUSSION: This report will be the first pilot study to investigate the beneficial effects of SCRA on elderly surgical patients. Previous studies have shown sufficient evidence on the effectiveness of learning therapy in healthy elderly people and in those with Dementia. Therefore, this study will clarify whether SCRA can improve cognitive function in the more specialized group of elderly surgical patients. TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trial Registry, UMIN000019832 . Registered on 18 November 2015.
Differences in gray matter structure correlated to nationalism and patriotism. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Scientific reports　6　29912-29912　2016年7月15日

DOI： 10.1038/srep29912 　

ISSN：2045-2322

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Nationalism and patriotism both entail positive evaluations of one's nation. However, the former inherently involves derogation of other nations, whereas the latter is independent of comparisons with other nations. We used voxel-based morphometry and psychological measures and determined nationalism and patriotism's association with gray matter density (rGMD) and their cognitive nature in healthy individuals (433 men and 344 women; age, 20.7 ± 1.9 years) using whole-brain multiple regression analyses and post hoc analyses. We found higher nationalism associated with greater rGMD in (a) areas of the posterior cingulate cortex and greater rGMD in (b) the orbitofrontal cortex, and smaller rGMD in (c) the right amygdala area. Furthermore, we found higher patriotism associated with smaller rGMD in the (d) rostrolateral prefrontal cortex. Post hoc analyses revealed the mean rGMD of the cluster (a) associated with compassion, that of (b) associated with feeling of superiority, that of (c) associated with suicide ideation, and that of (d) associated with quality of life. These results indicate that individual nationalism may be mediated by neurocognitive mechanisms in social-related areas and limbic neural mechanisms, whereas patriotism may be mediated by neurocognitive mechanisms in areas related to well-being.
OLIG2遺伝子多型(rs1059004)が脳白質の神経線維束の拡散異方性及び安静時脳灌流量に及ぼす効果の検討査読有り

小松浩, 竹内光, 菊地淑恵, 小野千晶, 坂井舞, 小高晃, 舩越俊一, 大野高志, 角藤芳久, 高橋雄太, 松岡洋夫, 瀧靖之, 川島隆太, 富田博秋

精神神経学雑誌　(2016特別号)　S367-S367　2016年6月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry 査読有り

Kotaro Hiraoka, Akira Sumiyoshi, Hiroi Nonaka, Takako Kikkawa, Ryuta Kawashima, Noriko Osumi

PLOS ONE　11　(6)　2016年6月

DOI： 10.1371/journal.pone.0158153 　

ISSN：1932-6203
Interpersonal frontopolar neural synchronization in group communication: An exploration toward fNIRS hyperscanning of natural interactions 査読有り

Takayuki Nozawa, Yukako Sasaki, Kohei Sakaki, Ryoichi Yokoyama, Ryuta Kawashima

NEUROIMAGE　133　484-497　2016年6月

DOI： 10.1016/j.neuroimage.2016.03.059 　

ISSN：1053-8119

eISSN：1095-9572
Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain 査読有り

Yui Mano, Ryuta Saito, Yoichi Haga, Tadao Matsunaga, Rong Zhang, Masashi Chonan, Shinya Haryu, Takuhiro Shoji, Aya Sato, Yukihiko Sonoda, Noriko Tsuruoka, Keisuke Nishiyachi, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Teiji Tominaga

JOURNAL OF NEUROSURGERY　124　(5)　1490-1500　2016年5月

DOI： 10.3171/2015.3.JNS142152 　

ISSN：0022-3085

eISSN：1933-0693
Reading Aloud and Solving Simple Arithmetic Calculation Intervention (Learning Therapy) Improves Inhibition, Verbal Episodic Memory, Focus Attention and Processing Speed in Healthy Elderly People: Evidence from a Randomized Controlled Trial. 国際誌査読有り

Nouchi R, Taki Y, Takeuchi H, Nozawa T, Sekiguchi A, Kawashima R

Frontiers in human neuroscience　10　(MAY2016)　217-217　2016年5月

DOI： 10.3389/fnhum.2016.00217 　

ISSN：1662-5161
Parental Praise Correlates with Posterior Insular Cortex Gray Matter Volume in Children and Adolescents 国際誌査読有り

Matsudaira Izumi, Yokota Susumu, Hashimoto Teruo, Takeuchi Hikaru, Asano Kohei, Asano Michiko, Sassa Yuko, Taki Yasuyuki, Kawashima Ryuta

PLOS ONE　11　(4)　e0154220　2016年4月21日

DOI： 10.1371/journal.pone.0154220 　

ISSN：1932-6203
Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents 査読有り

Hashimoto Teruo, Fukui Kento, Takeuchi Hikaru, Yokota Susumu, Kikuchi Yoshie, Tomita Hiroaki, Taki Yasuyuki, Kawashima Ryuta

CEREBRAL CORTEX　26　(4)　1795-1803　2016年4月

DOI： 10.1093/cercor/bhw020 　

ISSN：1047-3211
RECOVERY FROM BRAIN VOLUME REDUCTION AND COGNITIVE DYSFUNCTIONS 6 MONTHS AFTER SURGERY IN PATIENTS WITH BREAST CANCER 査読有り

Sekiguchi Atsushi, Sato Chiho, Kawai Masaaki, Ishida Takanori, Taki Yasuyuki, Ohuchi Noriaki, Kawashima Ryuta

PSYCHOSOMATIC MEDICINE　78　(3)　A73　2016年4月

ISSN：0033-3174
Neural correlates of second-language communication and the effect of language anxiety. 国際誌査読有り

Jeong H, Sugiura M, Suzuki W, Sassa Y, Hashizume H, Kawashima R

Neuropsychologia　84　e2-12　2016年4月

ISSN：0028-3932

eISSN：1873-3514
Noninvasive targeting delivery and in vivo magnetic resonance tracking method for live apoptotic cells in cerebral ischemia with functional Fe2O3 magnetic nanoparticles 査読有り

Atsushi Saito, Moataz M. Mekawy, Akira Sumiyoshi, Jorge J. Riera, Hiroaki Shimizu, Ryuta Kawashima, Teiji Tominaga

JOURNAL OF NANOBIOTECHNOLOGY　14　19　2016年3月

DOI： 10.1186/s12951-016-0173-1 　

ISSN：1477-3155
High-gamma power changes after cognitive intervention: preliminary results from twenty-one senior adult subjects. 国際誌査読有り

Yoritaka Akimoto, Takayuki Nozawa, Akitake Kanno, Toshimune Kambara, Mizuki Ihara, Takeshi Ogawa, Takakuni Goto, Yasuyuki Taki, Ryoichi Yokoyama, Yuka Kotozaki, Rui Nouchi, Atsushi Sekiguchi, Hikaru Takeuchi, Carlos Makoto Miyauchi, Motoaki Sugiura, Eiichi Okumura, Takashi Sunda, Toshiyuki Shimizu, Eiji Tozuka, Satoru Hirose, Tatsuyoshi Nanbu, Ryuta Kawashima

Brain and behavior　6　(3)　e00427-11　2016年3月

DOI： 10.1002/brb3.427 　

ISSN：2162-3279

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INTRODUCTION: Brain-imaging techniques have begun to be popular in evaluating the effectiveness of cognitive intervention training. Although gamma activities are rarely used as an index of training effects, they have several characteristics that suggest their potential suitability for this purpose. This pilot study examined whether cognitive training in elderly people affected the high-gamma activity associated with attentional processing and whether high-gamma power changes were related to changes in behavioral performance. METHODS: We analyzed (MEG) magnetoencephalography data obtained from 35 healthy elderly subjects (60-75 years old) who had participated in our previous intervention study in which the subjects were randomly assigned to one of the three types of intervention groups: Group V trained in a vehicle with a newly developed onboard cognitive training program, Group P trained with a similar program but on a personal computer, and Group C was trained to solve a crossword puzzle as an active control group. High-gamma (52-100 Hz) activity during a three-stimulus visual oddball task was measured before and after training. As a result of exclusion in the MEG data analysis stage, the final sample consisted of five subjects in Group V, nine subjects in Group P, and seven subjects in Group C. RESULTS: Results showed that high-gamma activities were differently altered between groups after cognitive intervention. In particular, members of Group V, who showed significant improvements in cognitive function after training, exhibited increased high-gamma power in the left middle frontal gyrus during top-down anticipatory target processing. High-gamma power changes in this region were also associated with changes in behavioral performance. CONCLUSIONS: Our preliminary results suggest the usefulness of high-gamma activities as an index of the effectiveness of cognitive training in elderly subjects.
Basal ganglia correlates of fatigue in young adults. 国際誌査読有り

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Scientific reports　6　21386-21386　2016年2月19日

DOI： 10.1038/srep21386 　

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Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.
入浴姿勢が脚部関節トルクと脳活動に与える影響

加藤智久, 佐藤稔, 松下大剛, 野澤孝之, 川島隆太

生体医工学　54　(1)　22-27　2016年
出版者・発行元：一般社団法人日本生体医工学会
DOI： 10.11239/jsmbe.54.22 　

ISSN：1347-443X

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The purpose of this study was to investigate how the posture during bathtub bathing affects the body and mind. Although many studies discussed comfort and safety of bathing, little has been studied from the perspective of biomechanics and neuroscience. In our two experiments, we manipulated bathers' posture and measured changes in biomechanical loads (torque at joints) and cerebral blood flow in frontal brain regions. Additionally, we also collected subjective evaluation of physical relaxation for each posture. The results of experiments with male subjects in the 20 s to 30 s showed that extending legs, in comparison to flexing legs, induced a physically relaxed state, which was revealed by subjective evaluation. Furthermore, we found significant decrease of joint torque in the ankle and hip and a significant increases of joint torque in the knee when legs were extended than when flexed. Our measurements indicated inhibition of neural activity in the left ventrolateral prefrontal region during leg extension. These results motivate further exploration of the possibility that physical relaxation with a less confined bathing posture may induce "liberation from verbal thinking".
Effects of Fast Simple Numerical Calculation Training on Neural Systems 査読有り

Hikaru Takeuchi, Tomomi Nagase, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Rui Nouchi, Ryuta Kawashima

NEURAL PLASTICITY　2016　5940634　2016年

DOI： 10.1155/2016/5940634 　

ISSN：2090-5904

eISSN：1687-5443
Human Cognitive Control Mode Estimation Using JINS MEME 査読有り

Takafumi Ogawa, Makoto Takahashi, Ryuta Kawashima

IFAC PAPERSONLINE　49　(19)　331-336　2016年

DOI： 10.1016/j.ifacol.2016.10.571 　

ISSN：2405-8963
The Experimental Study on the Ability to Manage Unexpected Events Using Micro-world Simulation 査読有り

Sohma Yoshitake, Yoshii Keito, Takahashi Makoto, Nakanowatari Hiroyuki, Yamamoto Yuki, Nejad Keyvan Kashkouli, Nozawa Takayuki, Sugiura Motoaki, Kawashima Ryuta

IFAC PAPERSONLINE　49　(19)　480-485　2016年

DOI： 10.1016/j.ifacol.2016.10.635 　

ISSN：2405-8963
Small Acute Benefits of 4 Weeks Processing Speed Training Games on Processing Speed and Inhibition Performance and Depressive Mood in the Healthy Elderly People: Evidence from a Randomized Control Trial. 国際誌査読有り

Nouchi Rui, Saito Toshiki, Nouchi Haruka, Kawashima Ryuta

Frontiers in aging neuroscience　8　302-302　2016年

DOI： 10.3389/fnagi.2016.00302 　
Impact of reading habit on white matter structure: Cross-sectional and longitudinal analyses. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

NeuroImage　133　378-389　2016年

DOI： 10.1016/j.neuroimage.2016.03.037 　

ISSN：1053-8119
The neural basis of the imitation drive. 国際誌査読有り

Hanawa S, Sugiura M, Nozawa T, Kotozaki Y, Yomogida Y, Ihara M, Akimoto Y, Thyreau B, Izumi S, Kawashima R

Social cognitive and affective neuroscience　11　(1)　66-77　2016年1月

DOI： 10.1093/scan/nsv089 　

ISSN：1749-5016
Are Plasma Oxytocin and Vasopressin Levels Reflective of Amygdala Activation during the Processing of Negative Emotions? A Preliminary Study. 国際誌査読有り

Motoki K, Sugiura M, Takeuchi H, Kotozaki Y, Nakagawa S, Yokoyama R, Kawashima R

Frontiers in psychology　7　480-480　2016年

DOI： 10.3389/fpsyg.2016.00480 　
Sex-Related Differences in the Effects of Sleep Habits on Verbal and Visuospatial Working Memory. 国際誌査読有り

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Frontiers in psychology　7　(JUL)　1128-1128　2016年

DOI： 10.3389/fpsyg.2016.01128 　

ISSN：1664-1078

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Poor sleep quality negatively affects memory performance, and working memory in particular. We investigated sleep habits related to sleep quality including sleep duration, daytime nap duration, nap frequency, and dream content recall frequency (DCRF). Declarative working memory can be subdivided into verbal working memory (VWM) and visuospatial working memory (VSWM). We hypothesized that sleep habits would have different effects on VWM and VSWM. To our knowledge, our study is the first to investigate differences between VWM and VSWM related to daytime nap duration, nap frequency, and DCRF. Furthermore, we tested the hypothesis that the effects of duration and frequency of daytime naps and DCRF on VWM and VSWM differed according to sex. We assessed 779 healthy right-handed individuals (434 males and 345 females; mean age: 20.7 ± 1.8 years) using a digit span forward and backward VWM task, a forward and backward VSWM task, and sleep habits scales. A correlation analysis was used to test the relationships between VWM capacity (VWMC) and VSWM capacity (VSWMC) scores and sleep duration, nap duration, nap frequency, and DCRF. Furthermore, multiple regression analyses were conducted to identify factors associated with VWMC and VSWMC scores and to identify sex-related differences. We found significant positive correlations between VSWMC and nap duration and DCRF, and between VWMC and sleep duration in all subjects. Furthermore, we found that working memory capacity (WMC) was positively correlated with nap duration in males and with sleep duration in females, and DCRF was positively correlated with VSWMC in females. Our finding of sex-related differences in the effects of sleep habits on WMC has not been reported previously. The associations between WMC and sleep habits differed according to sex because of differences in the underlying neural correlates of VWM and VSWM, and effectiveness of the sleep habits in males and females.
The Associations between Regional Gray Matter Structural Changes and Changes of Cognitive Performance in Control Groups of Intervention Studies. 国際誌査読有り

Takeuchi H, Taki Y, Sassa Y, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R

Frontiers in human neuroscience　9　(DEC)　681-681　2015年12月

DOI： 10.3389/fnhum.2015.00681 　

ISSN：1662-5161
White matter structures associated with loneliness in young adults. 国際誌査読有り

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Scientific reports　5　17001-17001　2015年11月20日

DOI： 10.1038/srep17001 　

ISSN：2045-2322

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Lonely individuals may exhibit dysfunction, particularly with respect to social empathy and self-efficacy. White matter (WM) structures related to loneliness have not yet been identified. We investigated the association between regional WM density (rWMD) using the UCLA Loneliness Scale in 776 healthy young students aged 18-27 years old. Loneliness scores were negatively correlated with rWMD in eight clusters: the bilateral inferior parietal lobule (IPL), right anterior insula (AI), posterior temporoparietal junction (pTPJ), left posterior superior temporal sulcus (pSTS), dorsomedial prefrontal cortex (dmPFC), and rostrolateral prefrontal cortex (RLPFC). The bilateral IPL, right AI, left pSTS, pTPJ, and RLPFC were strongly associated with Empathy Quotient (EQ), whereas the bilateral IPL, right AI, left pTPJ, and dmPFC were associated with General Self-Efficacy Scale (GSES) score. The neural correlates of loneliness comprise widespread reduction in WMD in areas related to self- and social cognition as well as areas associated with empathy and self-efficacy.
Neural substrates underlying reconcentration for the preparation of an appropriate cognitive state to prevent future mistakes: A functional magnetic resonance imaging study 査読有り

Naoki Miura, Takayuki Nozawa, Makoto Takahashi, Ryoichi Yokoyama, Yukako Sasaki, Kohei Sakaki, Ryuta Kawashima

Frontiers in Human Neuroscience　9　2015年11月3日

DOI： 10.3389/fnhum.2015.00603 　

ISSN：1662-5161
Working memory training impacts the mean diffusivity in the dopaminergic system. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Brain structure & function　220　(6)　3101-11　2015年11月

DOI： 10.1007/s00429-014-0845-2 　

ISSN：1863-2661 1863-2653

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Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT) on dopamine receptor binding potentials, the effects of WMT on MD remain unknown. In this study, we investigated these effects in young adult subjects who either underwent WMT or received no intervention for 4 weeks. Before and after the intervention or no-intervention periods, subjects underwent scanning sessions in diffusion-weighted imaging to measure MD. Compared with no intervention, WMT resulted in an increase in MD in the bilateral caudate, right putamen, left dorsolateral prefrontal cortex (DLPFC), right anterior cingulate cortex (ACC), right substantia nigra, and ventral tegmental area. Furthermore, the increase in performance on WMT tasks was significantly positively correlated with the mean increase in MD in the clusters of the left DLPFC and of the right ACC. These results suggest that WMT caused microstructural changes in the regions of the dopaminergic system in a way that is usually interpreted as a reduction in neural components.
Brain structures in the sciences and humanities. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Yuko Sassa, Ryuta Kawashima

Brain structure & function　220　(6)　3295-305　2015年11月

DOI： 10.1007/s00429-014-0857-y 　

ISSN：1863-2661 1863-2653

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The areas of academic interest (sciences or humanities) and area of study have been known to be associated with a number of factors associated with autistic traits. However, despite the vast amount of literature on the psychological and physiological characteristics associated with faculty membership, brain structural characteristics associated with faculty membership have never been investigated directly. In this study, we used voxel-based morphometry to investigate differences in regional gray matter volume (rGMV)/regional white matter volume (rWMV) between science and humanities students to test our hypotheses that brain structures previously robustly shown to be altered in autistic subjects are related to differences in faculty membership. We examined 312 science students (225 males and 87 females) and 179 humanities students (105 males and 74 females). Whole-brain analyses of covariance revealed that after controlling for age, sex, and total intracranial volume, the science students had significantly larger rGMV in an anatomical cluster around the medial prefrontal cortex and the frontopolar area, whereas the humanities students had significantly larger rWMV in an anatomical cluster mainly concentrated around the right hippocampus. These anatomical structures have been linked to autism in previous studies and may mediate cognitive functions that characterize differences in faculty membership. The present results may support the ideas that autistic traits and characteristics of the science students compared with the humanities students share certain characteristics from neuroimaging perspectives. This study improves our understanding of differences in faculty membership which is the link among cognition, biological factors, disorders, and education (academia).
Neuroanatomical correlates of the sense of control: Gray and white matter volumes associated with an internal locus of control. 国際誌査読有り

Teruo Hashimoto, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Ryuta Kawashima

NeuroImage　119　146-51　2015年10月1日

DOI： 10.1016/j.neuroimage.2015.06.061 　

ISSN：1053-8119 1095-9572

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A belief that effort is rewarded can develop incentive, achievement motivation, and self-efficacy. Individuals with such a belief attribute causes of events to themselves, not to external, uncontrollable factors, and are thus said to have an internal locus of control. An internal locus of control is a positive personality trait and has been thoroughly studied in applied psychology, but has not been widely examined in neuroscience. In the present study, correlations between locus of control assessment scores and brain volumes were examined in 777 healthy young adults using magnetic resonance imaging. A whole-brain multiple regression analysis with corrections for the effects of age, gender, and intelligence was conducted. Voxel-based morphometry analyses revealed that gray matter volumes in the anterior cingulate cortex, striatum, and anterior insula positively correlated with higher scores, which indicate an internal LOC. In addition, white matter volumes in the striatum showed significant correlations with an internal locus of control. These results suggest that cognitive, socioemotional, self-regulatory, and reward systems might be associated with internal control orientation. The finding of greater volumes in several brain regions in individuals with a stronger internal locus of control indicates that there is a neuroanatomical basis for the belief that one's efforts are rewarded.
Degree centrality and fractional amplitude of low-frequency oscillations associated with Stroop interference. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

NeuroImage　119　197-209　2015年10月1日

DOI： 10.1016/j.neuroimage.2015.06.058 　

ISSN：1053-8119 1095-9572

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Stroop paradigms are commonly used as an index of attention deficits and a tool for investigating functions of the frontal lobes and other associated structures. Here we investigated the correlation between resting-state functional magnetic imaging (fMRI) measures [degree centrality (DC)/fractional amplitude of low frequency fluctuations (fALFFs)] and Stroop interference. We examined this relationship in the brains of 958 healthy young adults. DC reflects the number of instantaneous functional connections between a region and the rest of the brain within the entire connectivity matrix of the brain (connectome), and thus how much of the node influences the entire brain areas, while fALFF is an indicator of the intensity of regional brain spontaneous activity. Reduced Stroop interference was associated with larger DC in the left lateral prefrontal cortex, left IFJ, and left inferior parietal lobule as well as larger fALFF in the areas of the dorsal attention network and the precuneus. These findings suggest that Stroop performance is reflected in resting state functional properties of these areas and the network. In addition, default brain activity of the dorsal attention network and precuneus as well as higher cognitive processes represented there, and default stronger global influence of the areas critical in executive functioning underlie better Stroop performance.
Amygdala and cingulate structure is associated with stereotype on sex-role. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Scientific reports　5　14220-14220　2015年9月30日

DOI： 10.1038/srep14220 　

ISSN：2045-2322

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Sex-role egalitarianism (SRE) is the belief that the sex of an individual should not influence the perception of his or her rights, abilities, obligations, and opportunities. Thus, low SRE reflects a more conservative stereotypical view on sex-role. Here we investigated anatomical correlates of individual differences in SRE in the present study. We used voxel-based morphometry, a questionnaire to determine an individual's SRE and associated psychological measures, and determined the association of SRE with gray matter structures and their cognitive nature in healthy individuals (375 men and 306 women; age, 20.6 ± 1.8 years). We demonstrated that higher SRE was associated with smaller regional gray matter density (rGMD) in the anterior part of the posterior cingulate cortex (PCC) and higher rGMD in the right amygdala. Post-hoc analyses revealed psychological measures characterized by contentious interpersonal orientations, such as contentious achievement motivation, were associated with lower SRE and higher rGMD in the anterior part of PCC. Depressive tendencies were associated with lower SRE and higher rGMD in the right amygdala. These findings suggest that variations in stereotype on sex role have roots in the limbic brain structures linked to contentious interpersonal orientation (cingulate) and negative mood (amygdala).
Neural Mechanism for Mirrored Self-face Recognition. 国際誌査読有り

Sugiura M, Miyauchi CM, Kotozaki Y, Akimoto Y, Nozawa T, Yomogida Y, Hanawa S, Yamamoto Y, Sakuma A, Nakagawa S, Kawashima R

Cerebral cortex (New York, N.Y. : 1991)　25　(9)　2806-14　2015年9月

DOI： 10.1093/cercor/bhu077 　

ISSN：1047-3211
An investigation of brain synchrony between students and their teacher during a secondary school EFL lesson 査読有り

Yamamoto R, Nozawa T, Jeong H, Ikeda S, Sakaki K, Kawashima R, Smith C, Ishikawa Y

Breaking Theory: New Directions in Applied Linguistics, Proceedings of the 48th Annual Meeting of the British Association for Applied Linguistics, London. UK: Scitsiugnil Press　201-212　2015年9月
Regional gray matter density is associated with morningness-eveningness: Evidence from voxel-based morphometry. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　117　294-304　2015年8月15日

DOI： 10.1016/j.neuroimage.2015.05.037 　

ISSN：1053-8119 1095-9572

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Diurnal preference (morningness-eveningness) is known to be associated with several individual characteristics that are important in the fields of sociology, education, and psychiatry. Despite this importance, the anatomical correlates of individual differences in morningness-eveningness are unknown, and these were investigated in the present study. We used voxel-based morphometry and a questionnaire to determine individual morningness-eveningness and its association with brain structures in 432 healthy men and 344 healthy women (age, 20.7±1.8years). We demonstrated that morningness (less eveningness) was associated with (a) lower regional gray matter density (rGMD) in the precuneus and adjacent areas, (b) lower rGMD in the left posterior parietal cortex and adjacent areas, and (c) higher rGMD in the bilateral orbitofrontal cortex. Further, our exploratory analyses revealed that (d) higher rGMD in hypothalamic areas around the bilateral suprachiasmatic nuclei were associated with morningness. These findings demonstrate that variations in morningness-eveningness reflect the GM structures of focal regions across the cortex, and suggest a structural basis for individual morningness-eveningness and its association with a wide range of psychological variables distributed across different GM areas of the brain.
Individual differences in cognitive performance and brain structure in typically developing children 国際誌査読有り

Yokota Susumu, Takeuchi Hikaru, Hashimoto Teruo, Hashizume Hiroshi, Asano Kohei, Asano Michiko, Sassa Yuko, Taki Yasuyuki, Kawashima Ryuta

DEVELOPMENTAL COGNITIVE NEUROSCIENCE　14　1-7　2015年8月

DOI： 10.1016/j.dcn.2015.05.003 　

ISSN：1878-9293
1-A-D-26. Pre-operative magnetoencephalographic spike localization in patients with surgically-cured epilepsy

Makoto Ishida, Masaki Iwasaki, Akitake Kanno, Kazutaka Jin, Yosuke Kakisaka, Kazuhiro Kato, Ryuta Kawashima, Nobukazu Nakasato

Clinical Neurophysiology　126　(6)　e57-e57　2015年6月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.clinph.2015.02.029 　

ISSN：1388-2457
Sonority-related markedness drives the misperception of unattested onset clusters in French listeners 査読有り

Maïonchi-Pino N, Taki Y, Magnan A, Yokoyama S, Écalle J, Takahashi K, Hashizume H, Kawashima R

L'Année psychologique　115　1-26　2015年6月

DOI： 10.4074/S0003503314000086 　
外科的に治療したてんかん患者における術前のMEG上でのスパイクの局在性(Pre-operative MEG spike localization in patients with surgically-cured epilepsy)

Ishida Makoto, Iwasaki Masaki, Jin Kazutaka, Kanno Akitake, Asagi Suguru, Miki Takashi, Kawashima Ryuta, Nakasato Nobukazu

医学検査　64　(別冊)　234-234　2015年5月
出版者・発行元： (一社)日本臨床衛生検査技師会
ISSN：0915-8669

eISSN：2188-5346
The impact of television viewing on brain structures: cross-sectional and longitudinal analyses. 国際誌査読有り

Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R

Cerebral cortex (New York, N.Y. : 1991)　25　(5)　1188-97　2015年5月

DOI： 10.1093/cercor/bht315 　

ISSN：1047-3211
Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Hiroshi Hashizume, Rui Nouchi, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

Human brain mapping　36　(5)　1808-27　2015年5月

DOI： 10.1002/hbm.22739 　

ISSN：1097-0193 1065-9471

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Recent investigations revealed mean diffusivity (MD) in gray matter and white matter areas is correlated with individual cognitive differences in healthy subjects and show unique properties and sensitivity that other neuroimaging tools donot have. In this study, we tested the hypothesis that the MD in the dopaminergic system is associated with individual differences in verbal creativity measured by divergent thinking (VCDT) and novelty seeking based on prior studies suggesting associations between these and dopaminergic functions. We examined this issue in a large sample of right-handed healthy young adults. We used analyses of MD and a psychological measure of VCDT, as well as personality measures of the Temperament and Character Inventory (TCI). Our results revealed associations between higher VCDT and lower MD in the bilateral globus pallidus. Furthermore, not only higher novelty seeking, but also lower harm avoidance, higher self-directedness, and higher self-transcendence were robustly associated with lower MD in the right globus pallidus, whereas higher persistence was associated with lower MD in the left globus pallidus. These personality variables were also associated with VCDT. The globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. These results suggested the MD in the globus pallidus, underlie the association between VCDT and multiple personalities in TCI including novelty seeking.
Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele. 国際誌査読有り

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　110　124-35　2015年4月15日

DOI： 10.1016/j.neuroimage.2015.01.053 　

ISSN：1053-8119 1095-9572

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The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD) and substantially exists in Asian populations, which have a lower ADHD prevalence. In this study, we investigated the effect of this allele on microstructural properties of the brain and on its functional activity during externally directed attention-demanding tasks and creative performance in the 765 Asian subjects. For this purpose, we employed diffusion tensor imaging, N-back functional magnetic resonance imaging paradigms, and a test to measure creativity by divergent thinking. The 5-repeat allele was significantly associated with increased originality in the creative performance, increased mean diffusivity (the measure of how the tissue includes water molecules instead of neural and vessel components) in the widespread gray and white matter areas of extensive areas, particularly those where DRD4 is expressed, and reduced task-induced deactivation in the areas that are deactivated during the tasks in the course of both the attention-demanding working memory task and simple sensorimotor task. The observed neural characteristics of 5-repeat allele carriers may lead to an increased risk of ADHD and behavioral deficits. Furthermore, the increased originality of creative thinking observed in the 5-repeat allele carriers may support the notion of the side of adaptivity of the widespread risk allele of psychiatric diseases.
Supramarginal activity in interoceptive attention tasks. 国際誌査読有り

Kashkouli Nejad K, Sugiura M, Nozawa T, Kotozaki Y, Furusawa Y, Nishino K, Nukiwa T, Kawashima R

Neuroscience letters　589　42-6　2015年3月4日

DOI： 10.1016/j.neulet.2015.01.031 　

ISSN：0304-3940
Beneficial Effects of Exercise and Cognitive Training on Cognitive Functions in Older Adults: Introduction of Smart Aging Studies 査読有り

Rui Nouchi, Ryuta Kawashima

Diet and Exercise in Cognitive Function and Neurological Diseases　205-212　2015年2月6日
出版者・発行元： Wiley Blackwell
DOI： 10.1002/9781118840634.ch18 　
The impact of parent-child interaction on brain structures: cross-sectional and longitudinal analyses. 国際誌査読有り

Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R

The Journal of neuroscience : the official journal of the Society for Neuroscience　35　(5)　2233-45　2015年2月4日

DOI： 10.1523/JNEUROSCI.0598-14.2015 　

ISSN：0270-6474
The structure of the amygdala associates with human sexual permissiveness: evidence from voxel-based morphometry. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Human brain mapping　36　(2)　440-8　2015年2月
出版者・発行元： 2
DOI： 10.1002/hbm.22638 　

ISSN：1097-0193 1065-9471

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Sexual behavior is a critical function of human procreation. Despite previous studies that investigated the neural mechanisms of basic human physiological sexual functions, the neural mechanisms that underlie individual differences in human sexual permissiveness remain unknown. We used voxel-based morphometry and a questionnaire (scale for sexual attitudes) to measure sexual permissiveness to investigate the gray matter and white matter structural correlates of sexual permissiveness. Sexual permissiveness was negatively correlated with regional gray matter density of the structures involving the right amygdala and surrounding areas, and positively correlated with regional white matter density of the white matter area that spread around the left amygdala to the hypothalamus area. There were no gender-specific relationships in the neural correlates of our findings. These findings suggest that structural variations in regions that play key roles in the basic physiological aspects of human sexuality underlie individual complex sexual attitudes in social life.
Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats. 国際誌査読有り

Hideaki Suzuki, Akira Sumiyoshi, Yasuharu Matsumoto, Ben A Duffy, Takeo Yoshikawa, Mark F Lythgoe, Kazuhiko Yanai, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Shimokawa

NeuroImage　105　84-92　2015年1月15日

DOI： 10.1016/j.neuroimage.2014.10.040 　

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Heart failure (HF) is characterized by a blood supply which is insufficient to meet the body's demand. HF can potentially affect the brain and is associated with a high prevalence of depression. However, the mechanisms by which the two are related remain largely unclear. Structural abnormalities of the ventral hippocampus have been observed in depression but have never been reported in HF. In this study, we thus investigated structural brain abnormality in HF using voxel-based morphometry (VBM) and histological analysis in a rat model of HF. T2-weighted images were obtained in rats with HF (n = 20) and sham rats (n = 17) and VBM was used to produce gray matter concentration (GMC) maps. Twenty-four hour locomotor activity was used as a sign of depressive behavior. Brains of HF and sham rats (n = 8, each) were fixed and histologically analyzed for the measurement of neurogenesis, the number of astrocytes and neurite outgrowth in the ventral hippocampus. VBM demonstrated significant GMC decrease in the hippocampus, which was restricted to the ventral segment. Similarly, neurogenesis and neurite outgrowth were significantly decreased and the number of astrocytes was significantly increased in HF rats as compared with sham rats in the ventral hippocampus. GMC values in the ventral hippocampus were significantly and negatively correlated with 24 hour locomotor activity in HF rats. In conclusion, the present study has demonstrated for the first time that the structural abnormality of the ventral hippocampus is associated with depressive symptoms in HF rats.
Comprehensive neural networks for guilty feelings in young adults. 国際誌査読有り

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　105　248-56　2015年1月15日

DOI： 10.1016/j.neuroimage.2014.11.004 　

ISSN：1053-8119 1095-9572

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Feelings of guilt are associated with widespread self and social cognitions, e.g., empathy, moral reasoning, and punishment. Neural correlates directly related to the degree of feelings of guilt have not been detected, probably due to the small numbers of subjects, whereas there are growing numbers of neuroimaging studies of feelings of guilt. We hypothesized that the neural networks for guilty feelings are widespread and include the insula, inferior parietal lobule (IPL), amygdala, subgenual cingulate cortex (SCC), and ventromedial prefrontal cortex (vmPFC), which are essential for cognitions of guilt. We investigated the association between regional gray matter density (rGMD) and feelings of guilt in 764 healthy young students (422 males, 342 females; 20.7 ± 1.8 years) using magnetic resonance imaging and the guilty feeling scale (GFS) for the younger generation which comprises interpersonal situation (IPS) and rule-breaking situation (RBS) scores. Both the IPS and RBS were negatively related to the rGMD in the right posterior insula (PI). The IPS scores were negatively correlated with rGMD in the left anterior insula (AI), right IPL, and vmPFC using small volume correction. A post hoc analysis performed on the significant clusters identified through these analyses revealed that rGMD activity in the right IPL showed a significant negative association with the empathy quotient. These findings at the whole-brain level are the widespread comprehensive neural network regions for guilty feelings. Interestingly, the novel finding in this study is that the PI was implicated as a common region for feelings of guilt with interaction between the IPS and RBS. Additionally, the neural networks including the IPL were associated with empathy and with regions implicated in moral reasoning (AI and vmPFC), and punishment (AI).
SAIDO Learning as a Cognitive Intervention for Dementia Care: A Preliminary Study 査読有り

Ryuta Kawashima, Deborah Lewis Hiller, Sheryl L. Sereda, Michelle Antonczak, Kara Serger, Denise Gannon, Shinji Ito, Hiroshi Otake, Daisaku Yunomae, Akihito Kobayashi, Christopher Muller, Hiroyuki Murata, Stephanie FallCreek

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION　16　(1)　56-62　2015年1月

DOI： 10.1016/j.jamda.2014.10.021 　

ISSN：1525-8610

eISSN：1538-9375
眼球と身体の動きを検出するアイウェアの開発

加納慎一郎, 一戸晋, 塩谷俊介, 井上一鷹, 川島隆太

生体医工学　53　S167_03-S167_03　2015年
出版者・発行元：一般社団法人日本生体医工学会
DOI： 10.11239/jsmbe.53.S167_03 　

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We have been developing the JINS MEME, an eyewear with a capability to detect eye and body movements. The horizontal and vertical EOG (electrooculogram) signals are measured and amplified with three metal dry electrodes placed near nasion and both sides of rhinion, of which positions correspond to the bridge and nose pads of eyewear, respectively. The user's mental states like drowsiness, fatigue, or interest to objects can be identified by the movements and blinking of the eyes extracted from the measured EOG. And the six-axis motion sensor (three-axis accelerometer and three-axis gyroscope) mounted in the eyewear measures the body motion. As the sensor located near the head is on the body axis, this eyewear is suitable to measure user's movement or shift of center of gravity during physical exercise with a high precision. The measured signals are used to extract various events of eye and body movement by the mounted MPU chip, or can be transmitted to the external devices via Bluetooth communication. In this presentation, the outline of the eyewear is introduced and some possible applications are shown.
Disrupted white matter integrity in anterior corona radiata of patients with anorexia nervosa 査読有り

Y. Sato, E. Aizawa, A. Sekiguchi, Y. Kotozaki, M. Sugiura, Y. Taki, H. Hashizume, T. Kochiyama, R. Kawashima, S. Fukudo

PSYCHOTHERAPY AND PSYCHOSOMATICS　84　(suppl 1)　62-62　2015年

ISSN：0033-3190

eISSN：1423-0348
Specific regions display altered grey matter volume in μ-opioid receptor knockout mice: MRI voxel-based morphometry. 国際誌査読有り

Kazumasu Sasaki, Akira Sumiyoshi, Hiroi Nonaka, Yoshiyuki Kasahara, Kazutaka Ikeda, F Scott Hall, George R Uhl, Masahiko Watanabe, Ryuta Kawashima, Ichiro Sora

British journal of pharmacology　172　(2)　654-67　2015年1月

DOI： 10.1111/bph.12807 　

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BACKGROUND AND PURPOSE: μ Opioid receptor knockout (MOP-KO) mice display several behavioural differences from wild-type (WT) littermates including differential responses to nociceptive stimuli. Brain structural changes have been tied to behavioural alterations noted in transgenic mice with targeting of different genes. Hence, we assess the brain structure of MOP-KO mice. EXPERIMENTAL APPROACH: Magnetic resonance imaging (MRI) voxel-based morphometry (VBM) and histological methods were used to identify structural differences between extensively backcrossed MOP-KO mice and WT mice. KEY RESULTS: MOP-KO mice displayed robust increases in regional grey matter volume in olfactory bulb, several hypothalamic nuclei, periaqueductal grey (PAG) and several cerebellar areas, most confirmed by VBM analysis. The largest increases in grey matter volume were detected in the glomerular layer of the olfactory bulb, arcuate nucleus of hypothalamus, ventrolateral PAG (VLPAG) and cerebellar regions including paramedian and cerebellar lobules. Histological analyses confirm several of these results, with increased VLPAG cell numbers and increased thickness of the olfactory bulb granule cell layer and cerebellar molecular and granular cell layers. CONCLUSIONS AND IMPLICATIONS: MOP deletion causes previously undescribed structural changes in specific brain regions, but not in all regions with high MOP receptor densities (e.g. thalamus, nucleus accumbens) or that exhibit adult neurogenesis (e.g. hippocampus). Volume differences in hypothalamus and PAG may reflect behavioural changes including hyperalgesia. Although the precise relationship between volume change and MOP receptor deletion was not determined from this study alone, these findings suggest that levels of MOP receptor expression may influence a broader range of neural structure and function in humans than previously supposed. LINKED ARTICLES: This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2.
Increased Posterior Hippocampal Volumes in Children with Lower Increase in Body Mass Index: A 3-Year Longitudinal MRI Study 国際誌査読有り

Hashimoto Teruo, Takeuchi Hikaru, Taki Yasuyuki, Yokota Susumu, Hashizume Hiroshi, Asano Kohei, Asano Michiko, Sassa Yuko, Nouchi Rui, Kawashima Ryuta

DEVELOPMENTAL NEUROSCIENCE　37　(2)　153-160　2015年

DOI： 10.1159/000370064 　

ISSN：0378-5866
Regional gray matter density associated with cognitive reflectivity-impulsivity: evidence from voxel-based morphometry. 国際誌査読有り

Ryoichi Yokoyama, Takayuki Nozawa, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Mayu Hanihara, Yuko Sassa, Ryuta Kawashima

PloS one　10　(3)　e0122666　2015年

DOI： 10.1371/journal.pone.0122666 　

ISSN：1932-6203

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When faced with a problem or choice, humans can use two different strategies: "cognitive reflectivity," which involves slow responses and fewer mistakes, or "cognitive impulsivity," which comprises of quick responses and more mistakes. Different individuals use these two strategies differently. To our knowledge, no study has directly investigated the brain regions involved in reflectivity-impulsivity; therefore, this study focused on associations between these cognitive strategies and the gray matter structure of several brain regions. In order to accomplish this, we enrolled 776 healthy, right-handed individuals (432 men and 344 women; 20.7 ± 1.8 years) and used voxel-based morphometry with administration of a cognitive reflectivity-impulsivity questionnaire. We found that high cognitive reflectivity was associated with greater regional gray matter density in the ventral medial prefrontal cortex. Our finding suggests that this area plays an important role in defining an individual's trait associated with reflectivity and impulsivity.
Effects of Different Types of Cognitive Training on Cognitive Function, Brain Structure, and Driving Safety in Senior Daily Drivers: A Pilot Study. 国際誌査読有り

Takayuki Nozawa, Yasuyuki Taki, Akitake Kanno, Yoritaka Akimoto, Mizuki Ihara, Ryoichi Yokoyama, Yuka Kotozaki, Rui Nouchi, Atsushi Sekiguchi, Hikaru Takeuchi, Carlos Makoto Miyauchi, Takeshi Ogawa, Takakuni Goto, Takashi Sunda, Toshiyuki Shimizu, Eiji Tozuka, Satoru Hirose, Tatsuyoshi Nanbu, Ryuta Kawashima

Behavioural neurology　2015　525901-525901　2015年

DOI： 10.1155/2015/525901 　

ISSN：1875-8584 0953-4180

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BACKGROUND: Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS: Thirty-seven healthy elderly daily drivers were randomly assigned to one of three training groups: Group V trained in a vehicle with a newly developed onboard cognitive training program, Group P trained with a similar program but on a personal computer, and Group C trained to solve a crossword puzzle. Before and after the 8-week training period, they underwent neuropsychological tests, structural brain magnetic resonance imaging, and driving safety tests. RESULTS: For cognitive function, only Group V showed significant improvements in processing speed and working memory. For driving safety, Group V showed significant improvements both in the driving aptitude test and in the on-road evaluations. Group P showed no significant improvements in either test, and Group C showed significant improvements in the driving aptitude but not in the on-road evaluations. CONCLUSION: The results support the effectiveness of the onboard training program in enhancing the elderly's abilities to drive safely and the potential advantages of a multimodal training approach.
The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. 国際誌査読有り

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Frontiers in psychology　6　912-912　2015年

DOI： 10.3389/fpsyg.2015.00912 　

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Previous neuroscientific studies have shown that the dopaminergic system plays an important role in creative potential measured by divergent thinking (CPMDT), emotional control, and motivational state. However, although associations between two of these four components have been previously established (e.g., the association between CPMDT and emotional control, the association between CPMDT and motivational state, etc.), the interactions between these four remain unknown. The purpose of this study was to reveal these interactions using path analyses. The Taq1A polymorphism of the dopamine D2 receptor (DRD2) gene was used for this purpose. For measuring emotional intelligence (EI), we used the Japanese version of the Emotional Intelligence Scale. CPMDT was measured using the S-A creativity test. Motivational state was measured using the Vigor subscale of the Japanese version of the Profile of Mood Scale (POMS). Data from 766 healthy, right-handed individuals (426 men and 340 women; 20.7 ± 1.9 years of age) were used in this study. There were significant and robust positive relationships among measures of CPMDT, EI, and motivational state across sex. In addition, the polymorphism of the DRD2 gene was significantly associated with EI, specifically in females. Path analysis in females indicates that the model in which (a) the DRD2 polymorphism primarily facilitates EI, (b) EI in turn facilitates CPMDT and leads to a better motivational state, and (c) a better motivational state also directly facilitates CPMDT explains the data in the most accurate manner. This study suggested a comprehensive picture of the cascade of the associations among dopamine, EI, motivational state, and CPMDT at least in females.
The Relationship between Processing Speed and Regional White Matter Volume in Healthy Young People. 国際誌査読有り

Daniele Magistro, Hikaru Takeuchi, Keyvan Kashkouli Nejad, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Yuko Sassa, Ryuta Kawashima

PloS one　10　(9)　e0136386　2015年

DOI： 10.1371/journal.pone.0136386 　

ISSN：1932-6203

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Processing speed is considered a key cognitive resource and it has a crucial role in all types of cognitive performance. Some researchers have hypothesised the importance of white matter integrity in the brain for processing speed; however, the relationship at the whole-brain level between white matter volume (WMV) and processing speed relevant to the modality or problem used in the task has never been clearly evaluated in healthy people. In this study, we used various tests of processing speed and Voxel-Based Morphometry (VBM) analyses, it is involves a voxel-wise comparison of the local volume of gray and white, to assess the relationship between processing speed and regional WMV (rWMV). We examined the association between processing speed and WMV in 887 healthy young adults (504 men and 383 women; mean age, 20.7 years, SD, 1.85). We performed three different multiple regression analyses: we evaluated rWMV associated with individual differences in the simple processing speed task, word-colour and colour-word tasks (processing speed tasks with words) and the simple arithmetic task, after adjusting for age and sex. The results showed a positive relationship at the whole-brain level between rWMV and processing speed performance. In contrast, the processing speed performance did not correlate with rWMV in any of the regions examined. Our results support the idea that WMV is associated globally with processing speed performance regardless of the type of processing speed task.
Postoperative Structural Brain Changes and Cognitive Dysfunction in Patients with Breast Cancer. 国際誌査読有り

Chiho Sato, Atsushi Sekiguchi, Masaaki Kawai, Yuka Kotozaki, Rui Nouchi, Hiroshi Tada, Hikaru Takeuchi, Takanori Ishida, Yasuyuki Taki, Ryuta Kawashima, Noriaki Ohuchi

PloS one　10　(11)　e0140655　2015年

DOI： 10.1371/journal.pone.0140655 　

ISSN：1932-6203

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OBJECTIVE: The primary purpose of this study was to clarify the influence of the early response to surgery on brain structure and cognitive function in patients with breast cancer. It was hypothesized that the structure of the thalamus would change during the early response after surgery due to the effects of anesthesia and would represent one aspect of an intermediate phenotype of postoperative cognitive dysfunction (POCD). METHODS: We examined 32 postmenopausal females with breast cancer and 20 age-matched controls. We assessed their cognitive function (attention, memory, and executive function), and performed brain structural MRI 1.5 ± 0.5 days before and 5.6 ± 1.2 days after surgery. RESULTS: We found a significant interaction between regional grey matter volume (rGMV) in the thalamus (P < 0.05, familywise error (FWE), small volume correction (SVC)) and one attention domain subtest (P = 0.001, Bonferroni correction) after surgery in the patient group compared with the control group. Furthermore, the changes in attention were significantly associated with sevoflurane anesthetic dose (r2 = 0.247, β = ‒0.471, P = 0.032) and marginally associated with rGMV changes in the thalamus (P = 0.07, FWE, SVC) in the Pt group. CONCLUSION: Our findings suggest that alterations in brain structure, particularly in the thalamus, may occur shortly after surgery and may be associated with attentional dysfunction. This early postoperative response to anesthesia may represent an intermediate phenotype of POCD. It was assumed that patients experiencing other risk factors of POCD, such as the severity of surgery, the occurrence of complications, and pre-existing cognitive impairments, would develop clinical POCD with broad and multiple types of cognitive dysfunction.
Temporal and Motor Representation of Rhythm in Fronto-Parietal Cortical Areas: An fMRI Study. 国際誌査読有り

Naho Konoike, Yuka Kotozaki, Hyeonjeong Jeong, Atsuko Miyazaki, Kohei Sakaki, Takamitsu Shinada, Motoaki Sugiura, Ryuta Kawashima, Katsuki Nakamura

PloS one　10　(6)　e0130120　2015年

DOI： 10.1371/journal.pone.0130120 　

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When sounds occur with temporally structured patterns, we can feel a rhythm. To memorize a rhythm, perception of its temporal patterns and organization of them into a hierarchically structured sequence are necessary. On the other hand, rhythm perception can often cause unintentional body movements. Thus, we hypothesized that rhythm information can be manifested in two different ways; temporal and motor representations. The motor representation depends on effectors, such as the finger or foot, whereas the temporal representation is effector-independent. We tested our hypothesis with a working memory paradigm to elucidate neuronal correlates of temporal or motor representation of rhythm and to reveal the neural networks associated with these representations. We measured brain activity by fMRI while participants memorized rhythms and reproduced them by tapping with the right finger, left finger, or foot, or by articulation. The right inferior frontal gyrus and the inferior parietal lobule exhibited significant effector-independent activations during encoding and retrieval of rhythm information, whereas the left inferior parietal lobule and supplementary motor area (SMA) showed effector-dependent activations during retrieval. These results suggest that temporal sequences of rhythm are probably represented in the right fronto-parietal network, whereas motor sequences of rhythm can be represented in the SMA-parietal network.
Neural correlates of second-language communication and the effect of language anxiety. 査読有り

Jeong H, Sugiura M, Suzuki W, Sassa Y, Hashizume H, Kawashima R

Neuropsychologia　66　182-192　2015年1月

DOI： 10.1016/j.neuropsychologia.2014.11.013 　

ISSN：0028-3932

eISSN：1873-3514
Adaptive ability to cope with atypical or novel situations involving tool use: an fMRI approach. 査読有り

Wakusawa K, Sugiura M, Sassa Y, Jeong H, Yomogida Y, Horie K, Sato S, Yokoyama H, Kure S, Takei N, Mori N, Kawashima R

Neuroscience research　90　72-82　2015年1月

DOI： 10.1016/j.neures.2014.03.008 　

ISSN：0168-0102
Electro- and magneto-encephalographic spike source localization of small focal cortical dysplasia in the dorsal peri-rolandic region. 国際誌査読有り

Hisashi Itabashi, Kazutaka Jin, Masaki Iwasaki, Eiichi Okumura, Akitake Kanno, Kazuhiro Kato, Teiji Tominaga, Ryuta Kawashima, Nobukazu Nakasato

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　125　(12)　2358-63　2014年12月

DOI： 10.1016/j.clinph.2014.02.028 　

ISSN：1388-2457

eISSN：1872-8952
Applying a cognitive training program using a brain training game to patients with schizophrenia: study protocol for a randomized trial 査読有り

Kunio Iizuka, Kazunori Matsumoto, Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Takayuki Nozawa, Hiroshi Hashizume, Ryoichi Yokoyama, Yukako Sasaki, Chika Obara, Hiroo Matsuoka, Ryuta Kawashima

EARLY INTERVENTION IN PSYCHIATRY　8　145-145　2014年11月

ISSN：1751-7885

eISSN：1751-7893
Correlations between brain structures and study time at home in healthy children: a longitudinal analysis 査読有り

Michiko Asano, Yasuyuki Taki, Hiroshi Hashizume, Hikaru Takeuchi, Benjamin Thyreau, Yuko Sassa, Ryuta Kawashima

BRAIN AND BEHAVIOR　4　(6)　801-811　2014年11月

DOI： 10.1002/brb3.278 　

ISSN：2162-3279
High-gamma activity in an attention network predicts individual differences in elderly adults' behavioral performance 査読有り

Akimoto Yoritaka, Nozawa Takayuki, Kanno Akitake, Ihara Mizuki, Goto Takakuni, Ogawa Takeshi, Kambara Toshimune, Sugiura Motoaki, Okumura Eiichi, Kawashima Ryuta

NEUROIMAGE　100　290-300　2014年10月15日

DOI： 10.1016/j.neuroimage.2014.06.037 　

ISSN：1053-8119
Association between resting-state functional connectivity and empathizing/systemizing. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

NeuroImage　99　312-22　2014年10月1日

DOI： 10.1016/j.neuroimage.2014.05.031 　

ISSN：1053-8119 1095-9572

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Empathizing is the drive to identify the mental status of other individuals and respond to it with an appropriate emotion; systemizing is the drive to analyze a system. Previously, we have shown that structures associated with the default mode network (DMN) and external attention system (EAS) are associated with empathizing and systemizing, respectively. Here we investigated the association between resting-state functional connectivity (RSFC) and empathizing/systemizing in 248 healthy young adults. We considered the medial prefrontal cortex (mPFC) and bilateral dorsolateral prefrontal cortices (DLPFCs), which are key nodes of DMN and EAS, as seed regions, and investigated correlations across subjects between individual empathizing/systemizing and RSFC between each seed region and other brain regions. We found that higher empathizing was associated with larger RSFC between the mPFC and areas in (a) the dorsal anterior cingulate cortex (dACC), (b) precuneus, and (c) left superior temporal sulcus (STS). Furthermore, there was an interaction effect between sex and systemizing on RSFC between the left DLPFC and dACC: males showed positive correlations between this RSFC and systemizing, whereas females showed the opposite tendency. Thus, empathizing was associated with increased positive functional coupling with the key node and other nodes of DMN, as well as the area associated with feeling another's pain. Systemizing was associated with increased positive functional coupling between the key nodes of EAS in males. These findings provide further support for the concept of an association between DMN/EAS and empathizing/systemizing.
Regional gray matter volume increases following 7days of voluntary wheel running exercise: a longitudinal VBM study in rats. 査読有り

Sumiyoshi A, Taki Y, Nonaka H, Takeuchi H, Kawashima R

NeuroImage　98　82-90　2014年9月

DOI： 10.1016/j.neuroimage.2014.04.075 　

ISSN：1053-8119
From social-signal detection to higher social cognition: an fMRI approach. 査読有り

Sugiura M, Yomogida Y, Mano Y, Sassa Y, Kambara T, Sekiguchi A, Kawashima R

Social cognitive and affective neuroscience　9　(9)　1303-1309　2014年9月
出版者・発行元： 9
DOI： 10.1093/scan/nst119 　

ISSN：1749-5024 1749-5016

eISSN：1749-5024
Fatigue and relating to others 3 months after the 2011 Great East Japan Earthquake. 国際誌査読有り

Seishu Nakagawa, Motoaki Sugiura, Atsushi Sekiguchi, Yuka Kotozaki, Tsuyoshi Araki, Sugiko Hanawa, Carlos Makoto Miyauchi, Atsushi Sakuma, Ryuta Kawashima

Psychiatry research　218　(3)　324-8　2014年8月30日
出版者・発行元： 3
DOI： 10.1016/j.psychres.2014.04.043 　

ISSN：1872-7123 0165-1781

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Most inhabitants of Tohoku district suffer from chronic fatigue after the 2011 Great East Japan Earthquake. Chronic fatigue following disasters may lead to serious illness, even death. Posttraumatic growth appears to counteract fatigue. We predicted that the chronic fatigue would be inversely related to the posttraumatic growth factor "relating to others," as represented by mutual helping and a strong sense of connection with humanity. Young 59 healthy volunteers, residing in Miyagi prefecture, were recruited 3 months after the disaster. We measured the subjects׳ total scores on the Japanese version of the Checklist Individual Strength questionnaire (CIS), the Trait Anxiety (T-A) subscale of the State-Trait Anxiety Inventory (STAI), the Center for Epidemiologic Studies Depression Scale (CES-D), and four subscores on the posttraumatic growth inventory (PTGI). Stepwise regression analyses were conducted with score on the CIS as the dependent variable and other scores as independent variables. Scores on the "relating to others" factor of the PTGI showed a significant negative relationship with the CIS score, whereas the scores on the T-A subscale of the STAI and the CES-D were positively related to the CIS score. Human ties and mutual help were negatively related to the degree of the chronic fatigue.
Improving cognitive function from children to old age: A systematic review of recent smart ageing intervention studies

Rui Nouchi, Ryuta Kawashima

Advances in neuroscience　2014年8月11日

DOI： 10.1155/2014/235479 　
Healthy children show gender differences in correlations between nonverbal cognitive ability and brain activation during visual perception. 国際誌査読有り

Asano K, Taki Y, Hashizume H, Sassa Y, Thyreau B, Asano M, Takeuchi H, Kawashima R

Neuroscience letters　577　66-71　2014年8月

DOI： 10.1016/j.neulet.2014.06.015 　

ISSN：0304-3940
Effects of multitasking-training on gray matter structure and resting state neural mechanisms. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Human brain mapping　35　(8)　3646-60　2014年8月
出版者・発行元： 8
DOI： 10.1002/hbm.22427 　

ISSN：1097-0193 1065-9471

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Multitasking (MT) constitutes engaging in two or more cognitive activities at the same time. MT-training improves performance on untrained MT tasks and alters the functional activity of the brain during MT. However, the effects of MT-training on neural mechanisms beyond MT-related functions are not known. We investigated the effects of 4 weeks of MT-training on regional gray matter volume (rGMV) and functional connectivity during rest (resting-FC) in young human adults. MT-training was associated with increased rGMV in three prefrontal cortical regions (left lateral rostral prefrontal cortex (PFC), dorsolateral PFC (DLPFC), and left inferior frontal junction), the left posterior parietal cortex, and the left temporal and lateral occipital areas as well as decreased resting-FC between the right DLPFC and an anatomical cluster around the ventral anterior cingulate cortex (ACC). Our findings suggest that participation in MT-training is as a whole associated with task-irrelevant plasticity (i.e., neural changes are not limited to certain specific task conditions) in regions and the network that are assumed to play roles in MT as well as diverse higher-order cognitive functions. We could not dissociate the effects of each task component and the diverse cognitive processes involved in MT because of the nature of the study, and these remain to be investigated.
Developmental changes in brain activation involved in the production of novel speech sounds in children. 国際誌査読有り

Hiroshi Hashizume, Yasuyuki Taki, Yuko Sassa, Benjamin Thyreau, Michiko Asano, Kohei Asano, Hikaru Takeuchi, Rui Nouchi, Yuka Kotozaki, Hyeonjeong Jeong, Motoaki Sugiura, Ryuta Kawashima

Human brain mapping　35　(8)　4079-89　2014年8月

DOI： 10.1002/hbm.22460 　

ISSN：1065-9471

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Older children are more successful at producing unfamiliar, non-native speech sounds than younger children during the initial stages of learning. To reveal the neuronal underpinning of the age-related increase in the accuracy of non-native speech production, we examined the developmental changes in activation involved in the production of novel speech sounds using functional magnetic resonance imaging. Healthy right-handed children (aged 6-18 years) were scanned while performing an overt repetition task and a perceptual task involving aurally presented non-native and native syllables. Productions of non-native speech sounds were recorded and evaluated by native speakers. The mouth regions in the bilateral primary sensorimotor areas were activated more significantly during the repetition task relative to the perceptual task. The hemodynamic response in the left inferior frontal gyrus pars opercularis (IFG pOp) specific to non-native speech sound production (defined by prior hypothesis) increased with age. Additionally, the accuracy of non-native speech sound production increased with age. These results provide the first evidence of developmental changes in the neural processes underlying the production of novel speech sounds. Our data further suggest that the recruitment of the left IFG pOp during the production of novel speech sounds was possibly enhanced due to the maturation of the neuronal circuits needed for speech motor planning. This, in turn, would lead to improvement in the ability to immediately imitate non-native speech.
Regional gray matter volume increases following 7 days of voluntary wheel running exercise: A longitudinal VBM study in rats 査読有り

Sumiyoshi A, Taki Y, Nonaka H, Takeuchi H, Kawashima R

Neuroimage　61　(4)　1206-1212　2014年7月

DOI： 10.1016/j.neuroimage.2012.04.010 　

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7月16日
Biofeedback-based training for stress management in daily hassles: an intervention study. 国際誌査読有り

Yuka Kotozaki, Hikaru Takeuchi, Atsushi Sekiguchi, Yuki Yamamoto, Takamitsu Shinada, Tsuyoshi Araki, Kei Takahashi, Yasuyuki Taki, Takeshi Ogino, Masashi Kiguchi, Ryuta Kawashima

Brain and behavior　4　(4)　566-79　2014年7月
出版者・発行元： 4
DOI： 10.1002/brb3.241 　

ISSN：2162-3279

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BACKGROUND: The day-to-day causes of stress are called daily hassles. Daily hassles are correlated with ill health. Biofeedback (BF) is one of the tools used for acquiring stress-coping skills. However, the anatomical correlates of the effects of BF with long training periods remain unclear. In this study, we aimed to investigate this. METHODS: PARTICIPANTS WERE ASSIGNED RANDOMLY TO TWO GROUPS: the intervention group and the control group. Participants in the intervention group performed a biofeedback training (BFT) task (a combination task for heart rate and cerebral blood flow control) every day, for about 5 min once a day. The study outcomes included MRI, psychological tests (e.g., Positive and Negative Affect Schedule, Center for Epidemiologic Studies Depression Scale, and Brief Job Stress Questionnaire), and a stress marker (salivary cortisol levels) before (day 0) and after (day 28) the intervention. RESULTS: We observed significant improvements in the psychological test scores and salivary cortisol levels in the intervention group compared to the control group. Furthermore, voxel-based morphometric analysis revealed that compared to the control group, the intervention group had significantly increased regional gray matter (GM) volume in the right lateral orbitofrontal cortex, which is an anatomical cluster that includes mainly the left hippocampus, and the left subgenual anterior cingulate cortex. The GM regions are associated with the stress response, and, in general, these regions seem to be the most sensitive to the detrimental effects of stress. CONCLUSIONS: Our findings suggest that our BFT is effective against the GM structures vulnerable to stress.
Effects of Contralateral Noise on the 20-Hz Auditory Steady State Response - Magnetoencephalography Study 査読有り

Hajime Usubuchi, Tetsuaki Kawase, Akitake Kanno, Izumi Yahata, Hiromitsu Miyazaki, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

PLOS ONE　9　(6)　e99457　2014年6月

DOI： 10.1371/journal.pone.0099457 　

ISSN：1932-6203
The Neural Basis of Event Simulation: An fMRI Study 査読有り

Yomogida Yukihito, Sugiura Motoaki, Akimoto Yoritaka, Miyauchi Carlos Makoto, Kawashima Ryuta

PLOS ONE　9　(5)　2014年5月2日

DOI： 10.1371/journal.pone.0096534 　

ISSN：1932-6203
The neural bases underlying social risk perception in purchase decisions 査読有り

Yokoyama Ryoichi, Nozawa Takayuki, Sugiura Motoaki, Yomogida Yukihito, Takeuchi Hikaru, Akimoto Yoritaka, Shibuya Satoru, Kawashima Ryuta

NEUROIMAGE　91　120-128　2014年5月1日

DOI： 10.1016/j.neuroimage.2014.01.036 　

ISSN：1053-8119
Anatomical correlates of quality of life: evidence from voxel-based morphometry. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Yuko Sassa, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Tomomi Nagase, Carlos Makoto Miyauchi, Ryuta Kawashima

Human brain mapping　35　(5)　1834-46　2014年5月
出版者・発行元： 5
DOI： 10.1002/hbm.22294 　

ISSN：1097-0193 1065-9471

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Quality of life (QOL) has been defined in many ways, and these definitions usually emphasize happiness and satisfaction with life. Health-related problems are known to cause lower QOL. However, the neural mechanisms underlying individual differences in QOL measured by questionnaire (QOLMQ) in young healthy subjects are unknown. QOL is essential to our well-being, and investigation of the neural mechanisms underlying QOL in uncompromised subjects is obviously of great scientific and social interest. We used voxel-based morphometry to investigate the association between regional gray matter volume (rGMV) and QOLMQ across the brain in healthy young adults (age, 21.4 ± 1.8 years) men (n = 88) and women (n = 68) in humans. We found significant negative relationships between QOLMQ and rGMV in a region in the left rostrolateral prefrontal cortex and regions in the dorsal part of the anterior cingulate gyrus and contingent cingulate regions. These findings show that structural variations in regions associated with processing of negative emotions such as fear and anger as well as those associated with evaluation of internally generated information are associated with QOLMQ. These findings suggest that these processes might be related to QOLMQ in healthy young adults.
Irony Comprehension: Social Conceptual Knowledge and Emotional Response 査読有り

Akimoto Yoritaka, Sugiura Motoaki, Yomogida Yukihito, Miyauchi Carlos Makoto, Miyazawa Shiho, Kawashima Ryuta

HUMAN BRAIN MAPPING　35　(4)　1167-1178　2014年4月

DOI： 10.1002/hbm.22242 　

ISSN：1065-9471
NEURAL UNDERPINNINGS OF POSTOPERATIVE COGNITIVE DYSFUNCTIONS (POCD) IN PATIENTS WITH BREAST CANCER 査読有り

Sato Chiho, Sekiguchi Atsushi, Kotozaki Yuka, Nouchi Rui, Takeuchi Hikaru, Taki Yasuyuki, Kawai Masaaki, Tada Hiroshi, Ishida Takanori, Kawashima Ryuta, Ohuchi Noriaki

PSYCHOSOMATIC MEDICINE　76　(3)　A29　2014年4月

ISSN：0033-3174
Four weeks of combination exercise training improved executive functions, episodic memory, and processing speed in healthy elderly people: evidence from a randomized controlled trial. 国際誌査読有り

Nouchi R, Taki Y, Takeuchi H, Sekiguchi A, Hashizume H, Nozawa T, Nouchi H, Kawashima R

Age (Dordrecht, Netherlands)　36　(2)　787-799　2014年4月
出版者・発行元： 2
DOI： 10.1007/s11357-013-9588-x 　

ISSN：1574-4647 0161-9152
Resilience after 3/11: structural brain changes 1 year after the Japanese earthquake. 査読有り

Sekiguchi A, Kotozaki Y, Sugiura M, Nouchi R, Takeuchi H, Hanawa S, Nakagawa S, Miyauchi CM, Araki T, Sakuma A, Taki Y, Kawashima R

Molecular psychiatry　20　(5)　552-554　2014年4月

DOI： 10.1038/mp.2014.28 　

ISSN：1359-4184

eISSN：1476-5578
Association between gray matter volume in the caudate nucleus and financial extravagance: findings from voxel-based morphometry. 国際誌査読有り

Ryoichi Yokoyama, Takayuki Nozawa, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Mayu Hanihara, Yuko Sassa, Ryuta Kawashima

Neuroscience letters　563　28-32　2014年3月20日

DOI： 10.1016/j.neulet.2014.01.026 　

ISSN：0304-3940 1872-7972

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Consumer behavior differs among individuals; one such common individual difference is financial extravagance. Recent research suggests that the activation of the caudate nucleus plays an important role in consumer behavior. However, to the best of our knowledge, no study has investigated the specific relationship between the caudate nucleus and consumer financial extravagance. Therefore, in this study, we investigated the association between individual differences in financial extravagance and regional gray matter volume in the caudate nucleus by using voxel-based morphometry (VBM). We recruited 776 healthy, right-handed individuals (432 men and 344 women; mean age=20.7 ± 1.8) and used voxel-based morphometry and a financial extravagance questionnaire to determine the association between financial extravagance and gray matter structure in the caudate nucleus. Our measure of financial extravagance was based on the novelty seeking subscales of the Japanese version of the Temperament and Character Inventory. A multiple regression analysis including financial extravagance, age, sex, Raven's Advanced Progressive Matrix score, total intracranial volume, and novelty seeking subscales was conducted to examine what variables were related to regional gray matter volume in the region of interest within the caudate nucleus. A significant positive correlation was found between the obtained financial extravagance score and regional gray matter volume in the caudate nucleus. We found that structural variations in the caudate nucleus contributed to individual differences in financial extravagance. This finding may provide a new neuroscientific approach to understanding individual characteristics of consumers.
Neural differences in processing of case particles in Japanese: an fMRI study. 査読有り

Hashimoto Y, Yokoyama S, Kawashima R

Brain and behavior　4　180-186　2014年3月
出版者・発行元： 2
DOI： 10.1002/brb3.201 　
Riding a Motorcycle Affects Cognitive Functions of Healthy Adults:- A preliminary controlled study -

Kawashima Ryuta, Nouchi Rui, Matsumoto Taisuke, Tanimoto Yasunori

International Journal of Automotive Engineering　5　(2)　73-76　2014年
出版者・発行元：公益社団法人自動車技術会
DOI： 10.20485/jsaeijae.5.2_73 　

ISSN：2185-0984

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We investigated whether riding a motorcycle in daily life has beneficial effects on the cognitive functions of healthy subjects. Twenty-two healthy right-handed men, who had a significant break from riding, participated in this study. They were randomly assigned to either the intervention or control group. The intervention group was asked to ride a motorcycle in their daily life for two months. The intervention group showed improvement of their visuospatial cognition compared with the control group. Results of this study indicate that riding a motorcycle in daily life could have beneficial effects in returning riders.
Remembering with gains and losses: Effects of monetary reward and punishment on successful encoding activation of source memories

Yayoi Shigemune, Takashi Tsukiura, Toshimune Kambara, Ryuta Kawashima

Cerebral Cortex　24　(5)　1319-1331　2014年

DOI： 10.1093/cercor/bhs415 　

ISSN：1047-3211

eISSN：1460-2199
Positive auditory cortical responses in patients with absent brainstem response 査読有り

Tetsuaki Kawase, Akitake Kanno, Yusuke Takata, Nobukazu Nakasato, Ryuta Kawashima, Toshimitsu Kobayashi

CLINICAL NEUROPHYSIOLOGY　125　(1)　148-153　2014年1月

DOI： 10.1016/j.clinph.2013.06.184 　

ISSN：1388-2457

eISSN：1872-8952
Creativity measured by divergent thinking is associated with two axes of autistic characteristics 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M. Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Yuko Sassa, Ryuta Kawashima

Frontiers in Psychology　5　(AUG)　921-921　2014年

DOI： 10.3389/fpsyg.2014.00921 　

eISSN：1664-1078
Optogenetic patterning of whisker-barrel cortical system in transgenic rat expressing channelrhodopsin-2. 国際誌査読有り

Tatsuya Honjoh, Zhi-Gang Ji, Yukinobu Yokoyama, Akira Sumiyoshi, Yuma Shibuya, Yoshiya Matsuzaka, Ryuta Kawashima, Hajime Mushiake, Toru Ishizuka, Hiromu Yawo

PloS one　9　(4)　e93706　2014年

DOI： 10.1371/journal.pone.0093706 　

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The rodent whisker-barrel system has been an ideal model for studying somatosensory representations in the cortex. However, it remains a challenge to experimentally stimulate whiskers with a given pattern under spatiotemporal precision. Recently the optogenetic manipulation of neuronal activity has made possible the analysis of the neuronal network with precise spatiotemporal resolution. Here we identified the selective expression of channelrhodopsin-2 (ChR2), an algal light-driven cation channel, in the large mechanoreceptive neurons in the trigeminal ganglion (TG) as well as their peripheral nerve endings innervating the whisker follicles of a transgenic rat. The spatiotemporal pattern of whisker irradiation thus produced a barrel-cortical response with a specific spatiotemporal pattern as evidenced by electrophysiological and functional MRI (fMRI) studies. Our methods of generating an optogenetic tactile pattern (OTP) can be expected to facilitate studies on how the spatiotemporal pattern of touch is represented in the somatosensory cortex, as Hubel and Wiesel did in the visual cortex.
Age-related differences in prefrontal, parietal, and hippocampal activations during correct rejections of faces 招待有り査読有り

Takashi Tsukiura, Yayoi Shigemune, Rui Nouchi, Toshimune Kambara, Ryuta Kawashima

JAPANESE PSYCHOLOGICAL RESEARCH　56　(1)　2-14　2014年1月

DOI： 10.1111/jpr.12017 　

ISSN：0021-5368

eISSN：1468-5884
発話産出におけるポライトネスの神経基盤

秋元頼孝, 杉浦元亮, 鈴木瑞恵, 野澤孝之, 塙杉子, 宮澤志保, 川島隆太

日本認知心理学会発表論文集　2014　(0)　94-94　2014年
出版者・発行元：日本認知心理学会
DOI： 10.14875/cogpsy.2014.0_94 　

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我々は、円滑な人間関係を確立・維持するために言語的配慮（ポライトネス）を行っている。ポライトネスには、他者に邪魔されたくないという欲求に配慮する方略（ネガティブポライトネス）と、他者に認められたいという欲求に配慮する方略（ポジティブポライトネス）の2方向の方略がある。本研究では、fMRIを用いて発話産出におけるポライトネスの神経基盤を検討した。実験参加者は、MRIの中で、日常場面で些細な失敗をした架空の友人に対して、 (1)ポジティブポライトネスを用いる、(2)ネガティブポライトネスを用いる条件、(3)ポライトネスを用いない、のいずれかの条件で発話の産出を行った。その結果、ネガティブポライトネス特異的な領域として左眼窩前頭皮質前部および右眼窩前頭皮質後部を、ネガティブポライトネス特異的な領域として右扁桃体を、両方のポライトネスに共通して関与する領域として右外側眼窩前頭皮質後部を同定した。
Advancement and limitation of SQUID-based MEG

Akitake Kanno, Nobukazu Nakasato, Nobukazu Nakasato, Ryuta Kawashima

Transactions of Japanese Society for Medical and Biological Engineering　52　OS-26　2014年1月1日

DOI： 10.11239/jsmbe.52.OS-26 　

ISSN：1881-4379

eISSN：1347-443X
Associations among imaging measures (2): the association between gray matter concentration and task-induced activation changes. 国際誌査読有り

Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sassa Y, Sekuguchi A, Kotozaki Y, Nakagawa S, Nagase T, Miyauchi CM, Kawashima R

Human brain mapping　35　(1)　185-98　2014年1月

DOI： 10.1002/hbm.22167 　

ISSN：1065-9471
Ongoing activity in temporally coherent networks predicts intra-subject fluctuation of response time to sporadic executive control demands. 国際誌査読有り

Nozawa T, Sugiura M, Yokoyama R, Ihara M, Kotozaki Y, Miyauchi CM, Kanno A, Kawashima R

PloS one　9　(6)　e99166　2014年

DOI： 10.1371/journal.pone.0099166 　
Spinal fMRI of interoceptive attention/awareness in experts and novices. 国際誌査読有り

Kashkouli Nejad K, Sugiura M, Thyreau B, Nozawa T, Kotozaki Y, Furusawa Y, Nishino K, Nukiwa T, Kawashima R

Neural plasticity　2014　679509-679509　2014年

DOI： 10.1155/2014/679509 　

ISSN：2090-5904
Working memory training improves emotional states of healthy individuals. 国際誌査読有り

Takeuchi H, Taki Y, Nouchi R, Hashizume H, Sekiguchi A, Kotozaki Y, Nakagawa S, Miyauchi CM, Sassa Y, Kawashima R

Frontiers in systems neuroscience　8　200-200　2014年

DOI： 10.3389/fnsys.2014.00200 　
Neuronal substrates characterizing two stages in visual object recognition 国際誌査読有り

Tomoya Taminato, Naoki Miura, Motoaki Sugiura, Ryuta Kawashima

Neuroscience Research　89　61-68　2014年1月1日

DOI： 10.1016/j.neures.2014.09.001 　

ISSN：0168-0102
Animacy or case marker order?: priority information for online sentence comprehension in a head-final language. 査読有り

Yokoyama S, Takahashi K, Kawashima R

PloS one　9　e93109　2014年
出版者・発行元： 3
DOI： 10.1371/journal.pone.0093109 　
Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Hiroshi Hashizume, Seishu Nakagawa, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Brain structure & function　219　(1)　71-83　2014年1月
出版者・発行元： 1
DOI： 10.1007/s00429-012-0485-3 　

ISSN：1863-2661 1863-2653

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Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-based morphometry and a questionnaire (achievement motivation scale) to measure individual achievement motivation and investigated the association between rGM density (rGMD) and achievement motivation [self-fulfillment achievement motivation (SFAM) and competitive achievement motivation (CAM) across the brain in healthy young adults (age 21.0 ± 1.8 years, men (n = 94), women (n = 91)]. SFAM and rGMD significantly and negatively correlated in the orbitofrontal cortex (OFC). CAM and rGMD significantly and positively correlated in the right putamen, insula, and precuneus. These results suggest that the brain areas that play central roles in externally modulated motivation (OFC and putamen) also contribute to SFAM and CAM, respectively, but in different ways. Furthermore, the brain areas in which rGMD correlated with CAM are related to cognitive processes associated with distressing emotions and social cognition, and these cognitive processes may characterize CAM.
White matter microstructural changes as vulnerability factors and acquired signs of post-earthquake distress. 国際誌査読有り

Atsushi Sekiguchi, Motoaki Sugiura, Yasuyuki Taki, Yuka Kotozaki, Rui Nouchi, Hikaru Takeuchi, Tsuyoshi Araki, Sugiko Hanawa, Seishu Nakagawa, Carlos Makoto Miyauchi, Atsushi Sakuma, Ryuta Kawashima

PloS one　9　(1)　e83967　2014年
出版者・発行元： 1
DOI： 10.1371/journal.pone.0083967 　

ISSN：1932-6203

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Many survivors of severe disasters need psychological support, even those not suffering post-traumatic stress disorder (PTSD). The critical issue in understanding the psychological response after experiencing severe disasters is to distinguish neurological microstructural underpinnings as vulnerability factors from signs of emotional distress acquired soon after the stressful life event. We collected diffusion-tensor magnetic resonance imaging (DTI) data from a group of healthy adolescents before the Great East Japan Earthquake and re-examined the DTIs and anxiety levels of 30 non-PTSD subjects from this group 3-4 months after the earthquake using voxel-based analyses in a longitudinal DTI study before and after the earthquake. We found that the state anxiety level after the earthquake was negatively associated with fractional anisotropy (FA) in the right anterior cingulum (Cg) before the earthquake (r = -0.61, voxel level p<0.0025, cluster level p<0.05 corrected), and positively associated with increased FA changes from before to after the earthquake in the left anterior Cg (r = 0.70, voxel level p<0.0025, cluster level p<0.05 corrected) and uncinate fasciculus (Uf) (r = 0.65, voxel level p<0.0025, cluster level p<0.05 corrected). The results demonstrated that lower FA in the right anterior Cg was a vulnerability factor and increased FA in the left anterior Cg and Uf was an acquired sign of state anxiety after the earthquake. We postulate that subjects with dysfunctions in processing fear and anxiety before the disaster were likely to have higher anxiety levels requiring frequent emotional regulation after the disaster. These findings provide new evidence of psychophysiological responses at the neural network level soon after a stressful life event and might contribute to the development of effective methods to prevent PTSD.
Long-term effects of postearthquake distress on brain microstructural changes. 国際誌査読有り

Atsushi Sekiguchi, Yuka Kotozaki, Motoaki Sugiura, Rui Nouchi, Hikaru Takeuchi, Sugiko Hanawa, Seishu Nakagawa, Carlos Makoto Miyauchi, Tsuyoshi Araki, Atsushi Sakuma, Yasuyuki Taki, Ryuta Kawashima

BioMed research international　2014　(Neuroscience)　180468-180468　2014年

DOI： 10.1155/2014/180468 　

ISSN：2314-6133 2314-6141

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Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability factor and increased WMI in the left anterior Cg and uncinate fasciculus (Uf) after the earthquake was an acquired sign of postearthquake distress. However, the long-term effects on WMI remained unclear. Here, we examined the 1-year WMI changes in 25 subjects to clarify long-term effects on the WMI. We found differential FAs in the right anterior Cg, bilateral Uf, left superior longitudinal fasciculus (SLF), and left thalamus, suggesting that synaptic enhancement and shrinkage were long-term effects. Additionally, the correlation between psychological measures related to postearthquake distress and the degree of WMI alternation in the right anterior Cg and the left Uf led us to speculate that temporal WMI changes in some subjects with emotional distress occurred soon after the disaster. We hypothesized that dynamic WMI changes predict a better prognosis, whereas persistently lower WMI is a marker of cognitive dysfunction, implying the development of anxiety disorders.
Regional gray matter volume is associated with empathizing and systemizing in young adults. 査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

PloS one　9　(1)　e84782　2014年1月
出版者・発行元： 1
DOI： 10.1371/journal.pone.0084782 　

ISSN：1932-6203
A longitudinal study of the relationship between personality traits and the annual rate of volume changes in regional gray matter in healthy adults. 査読有り

Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, Fukuda H

Human brain mapping　34　(12)　3347-3353　2013年12月

DOI： 10.1002/hbm.22145 　

ISSN：1065-9471
Resting state functional connectivity associated with trait emotional intelligence. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

NeuroImage　83　318-28　2013年12月

DOI： 10.1016/j.neuroimage.2013.06.044 　

ISSN：1095-9572 1053-8119

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Previous neuroimaging studies have suggested that trait emotional intelligence (TEI) is associated with components of the neural network involved in social cognition (SCN) and somatic marker circuitry (SMC). Our study is the first to investigate the association of TEI with resting-state functional connectivity (RSFC) between the key nodes of SCN and SMC [medial prefromtal cortex (mPFC) and bilateral anterior insula (AI), respectively] and other brain regions. We found that (a) the intrapersonal factor of TEI was negatively correlated with RSFC between mPFC and the anterior part of the right dorsolateral prefrontal cortex (DLPFC), (b) the TEI interpersonal factor score was positively correlated with RSFC between mPFC and the lingual gyrus, and (c) total TEI was positively correlated with RSFC between mPFC and the precuneus as well as (d) between the left AI and the middle part of the right DLPFC. Taken together with previous study findings, our findings can be comprehensively understood as neural mechanisms of SCN and SMC components are associated with TEI. In particular, the fluent interaction between SCN's two key nodes (mPFC and precuneus/PCC) [as well as between DMN's two key nodes] is suggested to be crucial for total TEI. Our study also indicated that (a) a clear functional separation between the two key nodes of the two major intrinsic networks, DMN and the task-positive network (mPFC and DLPFC), is important for higher intrapersonal TEI, (b) brain interactions involving vision-related areas (lingual gyrus) and the key node of SCN (mPFC) are important for interpersonal TEI, and (c) control of DLPFC over the key node of SMC (AI) is important for total TEI.
Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects. 査読有り

Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kakizaki M, Tsuji I, Kawashima R, Fukuda H

Human brain mapping　34　(10)　2418-2424　2013年10月

DOI： 10.1002/hbm.22073 　

ISSN：1065-9471
健常成人における性格と局所灰白質体積減少速度との相関

瀧靖之, Thyreay Thyreau, 木之村重男, 佐藤和則, 後藤了以, 川島隆太, 福田寛

日本老年医学会雑誌　50　(5)　682-682　2013年9月
出版者・発行元： (一社)日本老年医学会
ISSN：0300-9173
Altered brain activity in patients with anorexia nervosa during decision making: an fMRI study 査読有り

Sato Y, Aizawa E, Sekiguchi A, Kotozaki Y, Sugiura M, Taki Y, Hashizume H, Shoji T, Endo Y, Kochiyama T, Kawashima R, Fukudo S

Psychotherapy and Psychosomatics　82　(S1)　98-98　2013年9月
A longitudinal study of age- and gender-related annual rate of volume changes in regional gray matter in healthy adults 査読有り

Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, Fukuda H

Human Brain Mapping　34　(9)　2292-2301　2013年9月

DOI： 10.1002/hbm.22067 　

ISSN：1065-9471
Cross-linguistic influence of first language writing systems on brain responses to second language word reading in late bilinguals. 査読有り

Yokoyama S, Kim J, Uchida S, Miyamoto T, Yoshimoto K, Kawashima R

Brain and behavior　3　525-531　2013年9月
出版者・発行元： 5
DOI： 10.1002/brb3.153 　
Effects of working memory training on functional connectivity and cerebral blood flow during rest. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Calros M Miyauchi, Yuko Sassa, Ryuta Kawashima

Cortex; a journal devoted to the study of the nervous system and behavior　49　(8)　2106-25　2013年9月
出版者・発行元： 8
DOI： 10.1016/j.cortex.2012.09.007 　

ISSN：1973-8102 0010-9452

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Working memory (WM) training (WMT) alters the task-related brain activity and structure of the external attention system (EAS). We investigated whether WMT also alters resting-state brain mechanisms, which are assumed to reflect intrinsic brain activity and connectivity. Our study subjects were subjected to a 4-week WMT program and brain scans before and after the intervention for determining changes of functional connectivity and regional cerebral blood flow during rest (resting-FC/resting-rCBF). Compared with no-intervention, WMT (a) increased resting-FC between the medial prefrontal cortex (mPFC) and precuneus, which are key nodes of the default mode network (DMN), (b) decreased resting-FC between mPFC and the right posterior parietal cortex/right lateral prefrontal cortex (LPFC), which are key nodes of the EAS, and (c) increased resting-rCBF in the right LPFC. However, the training-related decreases in resting-FC between the key DMN node and the nodes of EAS were only observed when the whole brain signal was regressed out in individual analyses, and these changes were not observed when the whole brain signal was not regressed out in individual analyses. Further analyses indicated that these differences may be mediated by a weak but a widespread increase in resting-FC between the nodes of EAS and activity of multiple bilateral areas across the brain. These results showed that WMT induces plasticity in neural mechanisms involving DMN and the EAS during rest and indicated that intrinsic brain activity and connectivity can be affected by cognitive training.
Interactions between the heart and the brain in heart failure patients assessed by magnetic resonance imaging - interim results from Brain assessment and investigation in Heart Failure Trial (B-HeFT) 査読有り

H. Suzuki, Y. Matsumoto, H. Ota, Y. Kotozaki, J. Takahashi, K. Ito, Y. Fukumoto, R. Kawashima, Y. Taki, H. Shimokawa

European Heart Journal　34　(suppl 1)　P2732-P2732　2013年8月2日
出版者・発行元：
DOI： 10.1093/eurheartj/eht309.p2732 　

ISSN：0195-668X

eISSN：1522-9645
Voxel-based morphometry and histological analysis for evaluating hippocampal damage in a rat model of cardiopulmonary resuscitation. 国際誌査読有り

Suzuki H, Sumiyoshi A, Taki Y, Matsumoto Y, Fukumoto Y, Kawashima R, Shimokawa H

NeuroImage　77　215-221　2013年8月

DOI： 10.1016/j.neuroimage.2013.03.042 　

ISSN：1053-8119
Linear and curvilinear correlations of brain white matter volume, fractional anisotropy, and mean diffusivity with age using voxel-based and region-of-interest analyses in 246 healthy children. 国際誌査読有り

Taki Y, Thyreau B, Hashizume H, Sassa Y, Takeuchi H, Wu K, Kotozaki Y, Nouchi R, Asano M, Asano K, Fukuda H, Kawashima R

Human brain mapping　34　(8)　1842-56　2013年8月

DOI： 10.1002/hbm.22027 　

ISSN：1065-9471
Linear and curvilinear correlations of brain gray matter volume and density with age using voxel-based morphometry with the Akaike information criterion in 291 healthy children. 国際誌査読有り

Taki Y, Hashizume H, Thyreau B, Sassa Y, Takeuchi H, Wu K, Kotozaki Y, Nouchi R, Asano M, Asano K, Fukuda H, Kawashima R

Human brain mapping　34　(8)　1857-71　2013年8月

DOI： 10.1002/hbm.22033 　

ISSN：1065-9471
White matter structures associated with empathizing and systemizing in young adults. 国際誌査読有り

Takeuchi H, Taki Y, Thyreau B, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R

NeuroImage　77　222-236　2013年8月

DOI： 10.1016/j.neuroimage.2013.04.004 　

ISSN：1095-9572 1053-8119
Brain structures associated with executive functions during everyday events in a non-clinical sample. 査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

Brain structure & function　218　(4)　1017-1032　2013年7月
出版者・発行元： 4
DOI： 10.1007/s00429-012-0444-z 　

ISSN：1863-2661 1863-2653
Insular and hippocampal contributions to remembering people with an impression of bad personality

Takashi Tsukiura, Yayoi Shigemune, Rui Nouchi, Toshimune Kambara, Ryuta Kawashima

Social Cognitive and Affective Neuroscience　8　(5)　515-522　2013年6月

DOI： 10.1093/scan/nss025 　

ISSN：1749-5016

eISSN：1749-5024
Correlation between pulmonary function and brain volume in healthy elderly subjects. 国際誌査読有り

Yasuyuki Taki, Shigeo Kinomura, Satoru Ebihara, Benjamin Thyreau, Kazunori Sato, Ryoi Goto, Masako Kakizaki, Ichiro Tsuji, Ryuta Kawashima, Hiroshi Fukuda

Neuroradiology　55　(6)　689-95　2013年6月

DOI： 10.1007/s00234-013-1157-6 　

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INTRODUCTION: Cigarette smoking decreases brain regional gray matter volume and is related to chronic obstructive lung disease (COPD). COPD leads to decreased pulmonary function, which is represented by forced expiratory volume in one second percentage (FEV1.0 %); however, it is unclear if decreased pulmonary function is directly related to brain gray matter volume decline. Because there is a link between COPD and cognitive decline, revealing a direct relationship between pulmonary function and brain structure is important to better understand how pulmonary function affects brain structure and cognitive function. Therefore, the purpose of this study was to analyze whether there were significant correlations between FEV1.0 % and brain regional gray and white matter volumes using brain magnetic resonance (MR) image data from 109 community-dwelling healthy elderly individuals. METHODS: Brain MR images were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. RESULTS: We found a significant positive correlation between the regional white matter volume of the cerebellum and FEV1.0 % after adjusting for age, sex, and intracranial volume. CONCLUSION: Our results suggest that elderly individuals who have a lower FEV1.0 % have decreased regional white matter volume in the cerebellum. Therefore, preventing decreased pulmonary function is important for cerebellar white matter volume in the healthy elderly population.
加害行為に関する脳内表象の復号化：fMRI研究

宮内誠カルロス, 杉浦元亮, 蓬田幸人, 秋元頼孝, 月浦崇, 川島隆太

Proceedings of the 27th Annual Conference of the Japanese Society for Artificial Intelligenc　1　(1)　1-4　2013年6月1日
出版者・発行元： Japanese Society for Artificial Intelligence
Is the phonological deficit in developmental dyslexia related to impaired phonological representations and to universal phonological grammar? 査読有り

Maïonchi-Pino N, Taki Y, Yokoyama S, Magnan A, Takahashi K, Hashizume H, Écalle J, Kawashima R

Journal of experimental child psychology　115　53-73　2013年5月
出版者・発行元： 1
DOI： 10.1016/j.jecp.2012.10.006 　

ISSN：0022-0965
Activity in the primary somatosensory cortex induced by reflexological stimulation is unaffected by pseudo-information: a functional magnetic resonance imaging study. 査読有り

Miura N, Akitsuki Y, Sekiguchi A, Kawashima R

BMC complementary and alternative medicine　13　114　2013年5月

DOI： 10.1186/1472-6882-13-114 　

ISSN：1472-6882
A longitudinal study of structural brain network changes with normal aging 査読有り

Kai Wu, Yasuyuki Taki, Kazunori Sato, Haochen Qi, Ryuta Kawashima, Hiroshi Fukuda

Frontiers in Human Neuroscience　(2013)　2013年4月3日
出版者・発行元： Frontiers Media S. A.
DOI： 10.3389/fnhum.2013.00113 　

ISSN：1662-5161
RESILIENCE AFTER 3/11: BRAIN STRUCTURAL CHANGES ONE-YEAR AFTER THE GREAT EAST JAPAN EARTHQUAKE 査読有り

Sekiguchi Atsushi, Sugiura Motoaki, Kotozaki Yuka, Araki Tsuyoshi, Hanawa Sugiko, Nakagawa Seishu, Miyauchi Carlos M, Sakuma Atsushi, Taki Yasuyuki, Kawashima Ryuta

PSYCHOSOMATIC MEDICINE　75　(3)　A69-A70　2013年4月

ISSN：0033-3174
Anatomical correlates of self-handicapping tendency. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Yuko Sassa, Ryuta Kawashima

Cortex; a journal devoted to the study of the nervous system and behavior　49　(4)　1148-54　2013年4月
出版者・発行元： 4
DOI： 10.1016/j.cortex.2013.01.014 　

ISSN：1973-8102 0010-9452

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Self-handicaps are obstacles created (or claimed) by individuals in anticipation of failure. Despite the vast amount of psychological research on self-handicapping tendency, the neural mechanisms underlying individual differences in self-handicapping tendency in young and healthy subjects are unknown. We used voxel-based morphometry (VBM) and a questionnaire to measure individual self-handicapping tendency, and we investigated the association between regional gray matter volume (rGMV) and self-handicapping tendency across the brain in healthy young adult (mean age, 21.3 years; standard deviation - SD = 1.9) men (n = 94) and women (n = 91). We discovered that higher individual self-handicapping tendency was associated with larger rGMV in the subgenual cingulate gyrus (sgCG). A wide range of previous studies showed (a) the opposite pattern is seen in the association between rGMV in the sgCG and depression and (b) this area is active when negative emotions are suppressed. The present results suggest that the sgCG is also involved in self-handicapping, which is a behavior thought to be engaged in the protection of self-esteem.
Spatiotemporal Dynamics of High-Gamma Activities during a 3-Stimulus Visual Oddball Task 査読有り

Akimoto Yoritaka, Kanno Akitake, Kambara Toshimune, Nozawa Takayuki, Sugiura Motoaki, Okumura Eiichi, Kawashima Ryuta

PLOS ONE　8　(3)　2013年3月21日

DOI： 10.1371/journal.pone.0059969 　

ISSN：1932-6203

eISSN：1932-6203
必需品／贅沢品の認知と欲求構造の関係性についての心理研究査読有り

横山諒一, 野澤孝之, 野内類, 杉浦元亮, 川島隆太

東北大学研究所連携プロジェクト成果報告集「ヒューマンサイエンス＆テクノロジー」　(10)　58-61　2013年3月
Neural correlates of adaptive social responses to real-life frustrating situations: a functional MRI study. 査読有り

Sekiguchi A, Sugiura M, Yokoyama S, Sassa Y, Horie K, Sato S, Kawashima R

BMC neuroscience　14　29　2013年3月

DOI： 10.1186/1471-2202-14-29 　

ISSN：1471-2202
Different brain activation under left and right ventricular stimulation: an fMRI study in anesthetized rats. 国際誌

Hideaki Suzuki, Akira Sumiyoshi, Ryuta Kawashima, Hiroaki Shimokawa

PloS one　8　(2)　e56990　2013年

DOI： 10.1371/journal.pone.0056990 　

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BACKGROUND: Myocardial ischemia in the anterior wall of the left ventricule (LV) and in the inferior wall and/or right ventricle (RV) shows different manifestations that can be explained by the different innervations of cardiac afferent nerves. However, it remains unclear whether information from different areas of the heart, such as the LV and RV, are differently processed in the brain. In this study, we investigated the brain regions that process information from the LV or RV using cardiac electrical stimulation and functional magnetic resonance imaging (fMRI) in anesthetized rats because the combination of these two approaches cannot be used in humans. METHODOLOGY/PRINCIPAL FINDINGS: An electrical stimulation catheter was inserted into the LV or RV (n = 12 each). Brain fMRI scans were recorded during LV or RV stimulation (9 Hz and 0.3 ms width) over 10 blocks consisting of alternating periods of 2 mA for 30 sec followed by 0.2 mA for 60 sec. The validity of fMRI signals was confirmed by first and second-level analyses and temporal profiles. Increases in fMRI signals were observed in the anterior cingulate cortex and the right somatosensory cortex under LV stimulation. In contrast, RV stimulation activated the right somatosensory cortex, which was identified more anteriorly compared with LV stimulation but did not activate the anterior cingulate cortex. CONCLUSION/SIGNIFICANCE: This study provides the first evidence for differences in brain activation under LV and RV stimulation. These different brain processes may be associated with different clinical manifestations between anterior wall and inferoposterior wall and/or RV myocardial ischemia.
Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection. 国際誌査読有り

Misaki Aizawa-Kohama, Toshiki Endo, Masaaki Kitada, Shohei Wakao, Akira Sumiyoshi, Dai Matsuse, Yasumasa Kuroda, Takahiro Morita, Jorge J Riera, Ryuta Kawashima, Teiji Tominaga, Mari Dezawa

Cell transplantation　22　(9)　1613-25　2013年

DOI： 10.3727/096368912X658791 　

ISSN：0963-6897

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After severe spinal cord injury, spontaneous functional recovery is limited. Numerous studies have demonstrated cell transplantation as a reliable therapeutic approach. However, it remains unknown whether grafted neuronal cells could replace lost neurons and reconstruct neuronal networks in the injured spinal cord. To address this issue, we transplanted bone marrow stromal cell-derived neural progenitor cells (BM-NPCs) in a rat model of complete spinal cord transection 9 days after the injury. BM-NPCs were induced from bone marrow stromal cells (BMSCs) by gene transfer of the Notch-1 intracellular domain followed by culturing in the neurosphere method. As reported previously, BM-NPCs differentiated into neuronal cells in a highly selective manner in vitro. We assessed hind limb movements of the animals weekly for 7 weeks to monitor functional recovery after local injection of BM-NPCs to the transected site. To test the sensory recovery, we performed functional magnetic resonance imaging (fMRI) using electrical stimulation of the hind limbs. In the injured spinal cord, transplanted BM-NPCs were confirmed to express neuronal markers 7 weeks following the transplantation. Grafted cells successfully extended neurites beyond the transected portion of the spinal cord. Adjacent localization of synaptophysin and PSD-95 in the transplanted cells suggested synaptic formations. These results indicated survival and successful differentiation of BM-NPCs in the severely injured spinal cord. Importantly, rats that received BM-NPCs demonstrated significant motor recovery when compared to the vehicle injection group. Volumes of the fMRI signals in somatosensory cortex were larger in the BM-NPC-grafted animals. However, neuronal activity was diverse and not confined to the original hind limb territory in the somatosensory cortex. Therefore, reconstruction of neuronal networks was not clearly confirmed. Our results indicated BM-NPCs as an effective method to deliver neuronal lineage cells in a severely injured spinal cord. However, reestablishment of neuronal networks in completed transected spinal cord was still a challenging task.
Neural correlates of deception in social contexts in normally developing children. 国際誌査読有り

Susumu Yokota, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Benjamin Thyreau, Mari Tanaka, Ryuta Kawashima

Frontiers in human neuroscience　7　206-206　2013年

DOI： 10.3389/fnhum.2013.00206 　

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Deception is related to the ability to inhibit prepotent responses and to engage in mental tasks such as anticipating responses and inferring what another person knows, especially in social contexts. However, the neural correlates of deception processing, which requires mentalizing, remain unclear. Using functional magnetic resonance imaging (fMRI), we examined the neural correlates of deception, including mentalization, in social contexts in normally developing children. Healthy right-handed children (aged 8-9 years) were scanned while performing interactive games involving deception. The games varied along two dimensions: the type of reply (deception and truth) and the type of context (social and less social). Participants were instructed to deceive a witch and to tell the truth to a girl. Under the social-context conditions, participants were asked to consider what they inferred about protagonists' preferences from their facial expressions when responding to questions. Under the less-social-context conditions, participants did not need to consider others' preferences. We found a significantly greater response in the right precuneus under the social-context than under less-social-context conditions. Additionally, we found marginally greater activation in the right inferior parietal lobule (IPL) under the deception than under the truth condition. These results suggest that deception in a social context requires not only inhibition of prepotent responses but also engagement in mentalizing processes. This study provides the first evidence of the neural correlates of the mentalizing processes involved in deception in normally developing children.
THE PSYCHOLOGICAL AND NEURAL REPRESENTATION OF SOCIAL NORMS IN MAKING A PURCHASE DECISION 査読有り

Yokoyama Ryoichi, Nozawa Takayuki, Sugiura Motoaki, Yomogida Yukihito, Takeuchi Hikaru, Akimoto Yoritaka, Kawashima Ryuta

JOURNAL OF COGNITIVE NEUROSCIENCE　265-266　2013年

ISSN：0898-929X
Topological organization of functional brain networks in healthy children: differences in relation to age, sex, and intelligence. 査読有り

Wu K, Taki Y, Sato K, Hashizume H, Sassa Y, Takeuchi H, Thyreau B, He Y, Evans AC, Li X, Kawashima R, Fukuda H

PloS one　8　(2)　e55347　2013年

DOI： 10.1371/journal.pone.0055347 　

ISSN：1932-6203
Learning-dependent changes of associations between unfamiliar words and perceptual features: a 15-day longitudinal study 査読有り

Kambara Toshimune, Tsukiura Takashi, Shigemune Yayoi, Kanno Akitake, Nouchi Rui, Yomogida Yukihito, Kawashima Ryuta

LANGUAGE SCIENCES　35　80-86　2013年1月

DOI： 10.1016/j.langsci.2012.05.001 　

ISSN：0388-0001
Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study. 国際誌査読有り

Nakagawa S, Sugiura M, Akitsuki Y, Hosseini SM, Kotozaki Y, Miyauchi CM, Yomogida Y, Yokoyama R, Takeuchi H, Kawashima R

PloS one　8　(2)　e56606　2013年

DOI： 10.1371/journal.pone.0056606 　
Use of semantic information to interpret thematic information for real-time sentence comprehension in an SOV language. 査読有り

Yokoyama S, Takahashi K, Kawashima R

PloS one　8　e56106　2013年
出版者・発行元： 2
DOI： 10.1371/journal.pone.0056106 　
Differential contributions of the inferior parietal and inferior frontal regions to the processing of grammatical and semantic relationships in wh-questions 査読有り

Kambara T, Tsukiura T, Yokoyama S, Takahashi K, Shigemune Y, Miyamoto T, Takahashi D, Sato S, Kawashima R

Language sciences　37　14-21　2013年

DOI： 10.1016/j.langsci.2012.07.003 　

ISSN：0388-0001
Brain training game boosts executive functions, working memory and processing speed in the young adults: a randomized controlled trial. 国際誌査読有り

Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Toshimune Kambara, Atsushi Sekiguchi, Carlos Makoto Miyauchi, Yuka Kotozaki, Haruka Nouchi, Ryuta Kawashima

PloS one　8　(2)　e55518　2013年
出版者・発行元： 2
DOI： 10.1371/journal.pone.0055518 　

ISSN：1932-6203

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BACKGROUND: Do brain training games work? The beneficial effects of brain training games are expected to transfer to other cognitive functions. Yet in all honesty, beneficial transfer effects of the commercial brain training games in young adults have little scientific basis. Here we investigated the impact of the brain training game (Brain Age) on a wide range of cognitive functions in young adults. METHODS: We conducted a double-blind (de facto masking) randomized controlled trial using a popular brain training game (Brain Age) and a popular puzzle game (Tetris). Thirty-two volunteers were recruited through an advertisement in the local newspaper and randomly assigned to either of two game groups (Brain Age, Tetris). Participants in both the Brain Age and the Tetris groups played their game for about 15 minutes per day, at least 5 days per week, for 4 weeks. Measures of the cognitive functions were conducted before and after training. Measures of the cognitive functions fell into eight categories (fluid intelligence, executive function, working memory, short-term memory, attention, processing speed, visual ability, and reading ability). RESULTS AND DISCUSSION: Our results showed that commercial brain training game improves executive functions, working memory, and processing speed in young adults. Moreover, the popular puzzle game can engender improvement attention and visuo-spatial ability compared to playing the brain training game. The present study showed the scientific evidence which the brain training game had the beneficial effects on cognitive functions (executive functions, working memory and processing speed) in the healthy young adults. CONCLUSIONS: Our results do not indicate that everyone should play brain training games. However, the commercial brain training game might be a simple and convenient means to improve some cognitive functions. We believe that our findings are highly relevant to applications in educational and clinical fields. TRIAL REGISTRATION: UMIN Clinical Trial Registry 000005618.
Association of hair iron levels with creativity and psychological variables related to creativity. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Frontiers in human neuroscience　7　(DEC)　875-875　2013年

DOI： 10.3389/fnhum.2013.00875 　

ISSN：1662-5161

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Creativity generally involves the conception of original and valuable ideas. Previous studies have suggested an association between creativity and the dopaminergic system, and that physical activity facilitates creativity. Iron plays a key role in the dopaminergic system and physical activity. Here, we newly investigated the associations between hair iron levels and creativity, dopamine-related traits and states [novelty seeking, extraversion, and vigor (motivational state)], as well as the physical activity level. In the present study, we addressed this issue by performing a hair mineral analysis to determine iron levels and a behavioral creativity test of divergent thinking and related psychological measures among young adults (254 men, 88 women; mean age 20.79 ± 2.03 years). Iron levels did not show any significant association with creativity but displayed significant positive associations with novelty seeking, extraversion, and physical activity level. These results may be partly congruent with the notion that iron plays a key role in the dopaminergic system and imply that iron is important for traits and physical activity, which facilitate creativity. Future interventional or longitudinal studies are warranted to identify any causal effects.
The association between resting functional connectivity and creativity. 国際誌査読有り

Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R

Cerebral cortex (New York, N.Y. : 1991)　22　(12)　2921-2929　2012年12月

DOI： 10.1093/cercor/bhr371 　

ISSN：1047-3211
A voxel-based morphometry study of gray and white matter correlates of a need for uniqueness. 国際誌査読有り

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Hiroshi Hashizume, Seishu Nakagawa, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　63　(3)　1119-26　2012年11月15日
出版者・発行元： 3
DOI： 10.1016/j.neuroimage.2012.08.037 　

ISSN：1095-9572 1053-8119

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People appear to derive intrinsic satisfaction from the perception that they are unique, special, and separable from the masses, which is referred to as a need for uniqueness (NFU). NFU is a universal human trait, along with a tendency to conform to the beliefs and attitudes of others and social norms. We used voxel-based morphometry and a questionnaire to determine individual NFU and its association with brain structures in healthy men (94) and women (91; age, 21.3 ± 1.9 years). Individual NFU was associated with smaller gray matter volume of a cluster that included areas in (a) the left middle temporal gyrus, left superior temporal gyrus, and left superior temporal sulcus (STS); (b) the dorsal part of the anterior cingulate gyrus and the anterior part of the middle cingulate gyrus; and (c) the right inferior frontal gyrus and the ventral part of the precentral gyrus. Individual NFU was also associated with larger white matter concentration of a cluster that mainly included the body of the corpus callosum. These findings demonstrated that variations in NFU reflect the gray and white matter structures of focal regions. These findings suggest a biological basis for individual NFU, distributed across different gray and white matter areas of the brain.
Rhythm information represented in the fronto-parieto-cerebellar motor system. 国際誌査読有り

Naho Konoike, Yuka Kotozaki, Shigehiro Miyachi, Carlos Makoto Miyauchi, Yukihito Yomogida, Yoritaka Akimoto, Koji Kuraoka, Motoaki Sugiura, Ryuta Kawashima, Katsuki Nakamura

NeuroImage　63　(1)　328-38　2012年10月15日

DOI： 10.1016/j.neuroimage.2012.07.002 　

ISSN：1053-8119

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Rhythm is an essential element of human culture, particularly in language and music. To acquire language or music, we have to perceive the sensory inputs, organize them into structured sequences as rhythms, actively hold the rhythm information in mind, and use the information when we reproduce or mimic the same rhythm. Previous brain imaging studies have elucidated brain regions related to the perception and production of rhythms. However, the neural substrates involved in the working memory of rhythm remain unclear. In addition, little is known about the processing of rhythm information from non-auditory inputs (visual or tactile). Therefore, we measured brain activity by functional magnetic resonance imaging while healthy subjects memorized and reproduced auditory and visual rhythmic information. The inferior parietal lobule, inferior frontal gyrus, supplementary motor area, and cerebellum exhibited significant activations during both encoding and retrieving rhythm information. In addition, most of these areas exhibited significant activation also during the maintenance of rhythm information. All of these regions functioned in the processing of auditory and visual rhythms. The bilateral inferior parietal lobule, inferior frontal gyrus, supplementary motor area, and cerebellum are thought to be essential for motor control. When we listen to a certain rhythm, we are often stimulated to move our body, which suggests the existence of a strong interaction between rhythm processing and the motor system. Here, we propose that rhythm information may be represented and retained as information about bodily movements in the supra-modal motor brain system.
Neurovascular uncoupling under mild hypoxic hypoxia: an EEG-fMRI study in rats. 国際誌

Akira Sumiyoshi, Hideaki Suzuki, Hiroaki Shimokawa, Ryuta Kawashima

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　32　(10)　1853-8　2012年10月

DOI： 10.1038/jcbfm.2012.111 　

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The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation=83.6±12.1%) induced significant reductions in fMRI responses (P<0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen saturation were linearly correlated with the changes in the fMRI responses. These data further emphasize the importance of oxygen availability, which may regulate neurovascular coupling via the oxygen-dependent enzymatic synthesis of messenger molecules.
Beneficial effects of short-term combination exercise training on diverse cognitive functions in healthy older people: study protocol for a randomized controlled trial. 国際誌査読有り

Nouchi R, Taki Y, Takeuchi H, Hashizume H, Nozawa T, Sekiguchi A, Nouchi H, Kawashima R

Trials　13　200-200　2012年10月

DOI： 10.1186/1745-6215-13-200 　

ISSN：1745-6215
健常成人の加齢における局所脳灰白質量の減少 383人の脳MRI解析による縦断研究

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, Wu Kai, 川島隆太, 福田寛

日本老年医学会雑誌　49　(5)　654-654　2012年9月
出版者・発行元： (一社)日本老年医学会
ISSN：0300-9173
Pitfalls in the dipolar model for the neocortical EEG sources 査読有り

Jorge J. Riera, Takeshi Ogawa, Takakuni Goto, Akira Sumiyoshi, Hiroi Nonaka, Alan Evans, Hiroyoshi Miyakawa, Ryuta Kawashima

JOURNAL OF NEUROPHYSIOLOGY　108　(4)　956-975　2012年8月

DOI： 10.1152/jn.00098.2011 　

ISSN：0022-3077
習熟度の異なる日本人英語学習者による英文理解過程

横山悟, MANALO Emmanuel, 田中エリス伸枝, 高橋慶, 橋爪寛, JEONG Heyongjeong, 川島隆太

電子情報通信学会技術研究報告　112　(145(TL2012 10-25))　13-17　2012年7月14日
出版者・発行元：一般社団法人電子情報通信学会
ISSN：0913-5685

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外国語の習熟度の一側面として、処理時間の速度という側面がある。本研究では、日本人英語学習者による英文理解の速度を計測し、その速度と英語の習熟度との関係性を探る。その目的のため、習熟度のバラつきがある日本人英語学習者群に対し、英語習熟度テストと英文のself-paced reading taskを課し、両者の関係性を探索的に探った。本論文では、その実験結果を報告する。
Effects of processing speed training on cognitive functions and neural systems 招待有り

Hikaru Takeuchi, Ryuta Kawashima

REVIEWS IN THE NEUROSCIENCES　23　(3)　289-301　2012年6月

DOI： 10.1515/revneuro-2012-0035 　

ISSN：0334-1763
The Partial Incremental Argument Interpretation Model: A Real Time Simplex Sentence Comprehension Model of Japanese Language 査読有り

Satoru Yokoyama, Kei Yoshimoto, Ryuta Kawashima

Psychology of Language　159-183　2012年6月

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Chapter 5
スマートエイジングのためのバーチャル散歩システム査読有り

杉田典大, 杉原僚太, 吉澤誠, 本間経康, 阿部誠, 川島隆太

日本バーチャルリアリティ学会論文誌　17　(4)　497-504　2012年5月
出版者・発行元：特定非営利活動法人日本バーチャルリアリティ学会
DOI： 10.18974/tvrsj.17.4_497 　

ISSN：1344-011X

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In this study, a novel virtual walking system has been developed for putting the concept of advocating a positive acceptance of the later stages of life or aging, called smart aging, into practice. An essential core of the system can be found in striking the right balance between virtual and real worlds for old people to use pleasantly and safely. The system consists of a laptop computer, micro-projectors, and a completely new screen system mounted on the walking frame, called "walking frame mounted display (WFMD)." Users can physically walk with pleasure by the virtual reality technology and safely by the WFMD in the virtual environment. Furthermore, the WFMD does not require any sensors to be worn and is sufficiently inexpensive for home use. Comparison of experimental results clearly demonstrates that the real walking in a virtual environment using the WFMD is easier to use for old people than stamping their feet on the "Wii balance board" in the same environment.
The correlation between brain gray matter volume and empathizing and systemizing quotients in healthy children. 国際誌査読有り

Sassa Y, Taki Y, Takeuchi H, Hashizume H, Asano M, Asano K, Wakabayashi A, Kawashima R

NeuroImage　60　(4)　2035-2041　2012年5月

DOI： 10.1016/j.neuroimage.2012.02.021 　

ISSN：1053-8119
Brain structural changes as vulnerability factors and acquired signs of post-earthquake stress. 査読有り

Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R

Molecular psychiatry　18　(5)　618-623　2012年5月

DOI： 10.1038/mp.2012.51 　

ISSN：1359-4184

eISSN：1476-5578
Beneficial effects of reading aloud and solving simple arithmetic calculations (learning therapy) on a wide range of cognitive functions in the healthy elderly: study protocol for a randomized controlled trial. 国際誌査読有り

Nouchi R, Taki Y, Takeuchi H, Hashizume H, Nozawa T, Sekiguchi A, Nouchi H, Kawashima R

Trials　13　32-32　2012年4月

DOI： 10.1186/1745-6215-13-32 　

ISSN：1745-6215
ヒト脳の正常発達・加齢に伴う脳形態およびネットワーク構造の変化健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 瀧靖之, Wu Kai, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 秋本達也, 川島隆太

ナノ医工学年報　5　(1)　91-100　2012年3月
出版者・発行元：東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN：1882-4692
Age-related changes in topological organization of structural brain networks in healthy individuals 査読有り

Kai Wu, Yasuyuki Taki, Kazunori Sato, Shigeo Kinomura, Ryoi Goto, Ken Okada, Ryuta Kawashima, Yong He, Alan C. Evans, Hiroshi Fukuda

HUMAN BRAIN MAPPING　33　(3)　552-568　2012年3月

DOI： 10.1002/hbm.21232 　

ISSN：1065-9471

eISSN：1097-0193
Coupling between gamma oscillation and fMRI signal in the rat somatosensory cortex: its dependence on systemic physiological parameters. 国際誌査読有り

Akira Sumiyoshi, Hideaki Suzuki, Takeshi Ogawa, Jorge J Riera, Hiroaki Shimokawa, Ryuta Kawashima

NeuroImage　60　(1)　738-46　2012年3月

DOI： 10.1016/j.neuroimage.2011.12.082 　

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The simultaneous recordings of neuronal and hemodynamic signals have revealed a significant involvement of high frequency bands (e.g., gamma range, 25-70 Hz) in neurovascular coupling. However, the dependence on a physiological parameter is unknown. In this study, we performed simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings in 12 Wistar rats using a conventional forepaw stimulation paradigm and concurrently monitored the systemic physiological parameters of the partial pressure of arterial oxygen, partial pressure of arterial carbon dioxide, pH, mean arterial blood pressure, and heart rate through the rat femoral artery. The high frequency bands in the artifact-free EEG signals, especially those in the gamma range, demonstrated a maximum correlation with fMRI signals in the rat somatosensory cortex. A multiple linear regression analysis demonstrated that the correlation coefficient between the gamma power and fMRI signal depended on the actual values of the physiological parameters (R(2)=0.20, p<0.05), whereas the gamma power and fMRI signal by itself were independent. Among the parameters, the heart rate had a statistically significant slope (95% CI: 0.00027-0.0016, p<0.01) in a multiple linear regression model. These results indicate that neurovascular coupling is mainly driven by gamma oscillations, as expected, but coupling or potential decoupling is strongly influenced by systemic physiological parameters, which dynamically reflect the baseline vital status of the subject.
健常成人の高感度C反応性蛋白と局所脳灰白質量との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 福田寛, 川島隆太

日本医学放射線学会学術集会抄録集　71回　S199-S199　2012年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：0048-0428

eISSN：1347-7951
Regional gray and white matter volume associated with Stroop interference: evidence from voxel-based morphometry. 国際誌査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R

NeuroImage　59　(3)　2899-2907　2012年2月
出版者・発行元： 3
DOI： 10.1016/j.neuroimage.2011.09.064 　

ISSN：1095-9572 1053-8119
Self-face evaluation and self-esteem in young females: an fMRI study using contrast effect. 査読有り

Oikawa H, Sugiura M, Sekiguchi A, Tsukiura T, Miyauchi CM, Hashimoto T, Takano-Yamamoto T, Kawashima R

NeuroImage　59　(4)　3668-3676　2012年2月
出版者・発行元： 4
DOI： 10.1016/j.neuroimage.2011.10.098 　

ISSN：1095-9572 1053-8119
Brain development in childhood. 査読有り

Taki Y, Kawashima R

The open neuroimaging journal　6　103-110　2012年

DOI： 10.2174/1874440001206010103 　
Neural substrates of grammatical information retrieval during sentence comprehension.

Kei Takahashi, Satoru Yokoyama, Toshimune Kambara, Ryuta Kawashima

2012年
Effects of the Higashi-Nihon earthquake: posttraumatic stress, psychological changes, and cortisol levels of survivors. 国際誌査読有り

Yuka Kotozaki, Ryuta Kawashima

PloS one　7　(4)　e34612　2012年

DOI： 10.1371/journal.pone.0034612 　

eISSN：1932-6203
Effect of the survival judgment task on memory performance in subclinically depressed people 査読有り

Rui Nouchi, Ryuta Kawashima

FRONTIERS IN PSYCHOLOGY　3　114　2012年

DOI： 10.3389/fpsyg.2012.00114 　

ISSN：1664-1078
Clinical application of magnetoencephalography

Akitake Kanno, Nobukazu Nakasato, Ryuta Kawashima

Journal of the Institute of Electrical Engineers of Japan　132　(5)　290-293　2012年1月1日
出版者・発行元：一般社団法人電気学会
DOI： 10.1541/ieejjournal.132.290 　

ISSN：1340-5551
Sleep duration during weekdays affects hippocampal gray matter volume in healthy children. 国際誌査読有り

Yasuyuki Taki, Hiroshi Hashizume, Benjamin Thyreau, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

NeuroImage　60　(1)　471-475　2012年

DOI： 10.1016/j.neuroimage.2011.11.072 　

ISSN：1053-8119
Correlation among body height, intelligence, and brain gray matter volume in healthy children. 国際誌査読有り

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Kohei Asano, Yuka Kotozaki, Rui Nouchi,Array, Hiroshi Fukuda, Ryuta Kawashima

NeuroImage　59　(2)　1023-1027　2012年

DOI： 10.1016/j.neuroimage.2011.08.092 　

ISSN：1053-8119
第2言語の習熟度と語彙処理速度の検証－語彙判断課題および意味判断課題の反応時間から－

千葉克裕, 横山悟, 吉本啓, 川島隆太

東北大学高等教育開発推進センター紀要　7　(7)　35-42　2012年
出版者・発行元：東北大学高等教育開発推進センター
ISSN：1881-0853
Neuro-typology of sentence comprehension: Cross-linguistic difference in canonical word order affects brain responses during sentence comprehension. 査読有り

Hashimoto Y, Yokoyama S, Kawashima R

The Open Medical Imaging Journal　6　62-69　2012年

DOI： 10.2174/1874347101206010062 　
Left Inferior Frontal Activations Differentially Modulated by Scrambling in Ditransitive Sentences 査読有り

Koizumi M, Kim J, Kimura N, Yokoyama S, Sato S, Horie K, Kawashima R

The Open Medical Imaging Journal　6　70-79　2012年

DOI： 10.2174/1874347101206010070 　
Mechanism of case processing in the brain: an fMRI study. 査読有り

Yokoyama S, Maki H, Hashimoto Y, Toma M, Kawashima R

PloS one　7　e40474　2012年
出版者・発行元： 7
DOI： 10.1371/journal.pone.0040474 　
Brain training game improves executive functions and processing speed in the elderly: a randomized controlled trial. 国際誌査読有り

Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Yuko Akitsuki, Yayoi Shigemune, Atsushi Sekiguchi, Yuka Kotozaki, Takashi Tsukiura, Yukihito Yomogida, Ryuta Kawashima

PloS one　7　(1)　e29676　2012年
出版者・発行元： 1
DOI： 10.1371/journal.pone.0029676 　

ISSN：1932-6203

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BACKGROUND: The beneficial effects of brain training games are expected to transfer to other cognitive functions, but these beneficial effects are poorly understood. Here we investigate the impact of the brain training game (Brain Age) on cognitive functions in the elderly. METHODS AND RESULTS: Thirty-two elderly volunteers were recruited through an advertisement in the local newspaper and randomly assigned to either of two game groups (Brain Age, Tetris). This study was completed by 14 of the 16 members in the Brain Age group and 14 of the 16 members in the Tetris group. To maximize the benefit of the interventions, all participants were non-gamers who reported playing less than one hour of video games per week over the past 2 years. Participants in both the Brain Age and the Tetris groups played their game for about 15 minutes per day, at least 5 days per week, for 4 weeks. Each group played for a total of about 20 days. Measures of the cognitive functions were conducted before and after training. Measures of the cognitive functions fell into four categories (global cognitive status, executive functions, attention, and processing speed). Results showed that the effects of the brain training game were transferred to executive functions and to processing speed. However, the brain training game showed no transfer effect on any global cognitive status nor attention. CONCLUSIONS: Our results showed that playing Brain Age for 4 weeks could lead to improve cognitive functions (executive functions and processing speed) in the elderly. This result indicated that there is a possibility which the elderly could improve executive functions and processing speed in short term training. The results need replication in large samples. Long-term effects and relevance for every-day functioning remain uncertain as yet. TRIAL REGISTRATION: UMIN Clinical Trial Registry 000002825.
Neural correlates of the difference between working memory speed and simple sensorimotor speed: an fMRI study. 査読有り

Takeuchi H, Sugiura M, Sassa Y, Sekiguchi A, Yomogida Y, Taki Y, Kawashima R

PloS one　7　(1)　e30579　2012年
出版者・発行元： 1
DOI： 10.1371/journal.pone.0030579 　

ISSN：1932-6203
White matter structures associated with emotional intelligence: Evidence from diffusion tensor imaging. 国際誌査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R

Human brain mapping　34　(5)　1025-1034　2011年12月

DOI： 10.1002/hbm.21492 　

ISSN：1097-0193 1065-9471
Correlation between gray matter density-adjusted brain perfusion and age using brain MR images of 202 healthy children. 査読有り

Taki Y, Hashizume H, Sassa Y, Takeuchi H, Wu K, Asano M, Asano K, Fukuda H, Kawashima R

Human brain mapping　32　(11)　1973-1985　2011年11月

DOI： 10.1002/hbm.21163 　

ISSN：1065-9471
Large-scale heterogeneous representation of sound attributes in rat primary auditory cortex: from unit activity to population dynamics. 国際誌査読有り

Takeshi Ogawa, Jorge Riera, Takakuni Goto, Akira Sumiyoshi, Hiroi Nonaka, Karim Jerbi, Olivier Bertrand, Ryuta Kawashima

The Journal of neuroscience : the official journal of the Society for Neuroscience　31　(41)　14639-53　2011年10月12日

DOI： 10.1523/JNEUROSCI.0086-11.2011 　

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Recent evidence indicates the existence of pyramidal cells (PCs) and interneurons with nontrivial tuning characteristics for sound attributes in the primary auditory cortex (A1) of mammals. These neurons are functionally distributed into layers and sparsely organized at a small scale. However, their topological locations at a large scale in A1 have not yet been investigated. Furthermore, these neurons are usually classified from fine maps of attribute-dependent spiking activity, and not much attention is paid to population postsynaptic potentials related to their activity. We used extracellular recordings obtained from multiple sites in A1 of adult rats to determine neuronal codifiers for sound attributes defined by coarse representations of the population dose-response curves. We demonstrated that these codifiers, majorly involving PCs, are heterogeneously distributed along A1. Spiking activity in these neurons during stimulation was correlated to β (12-25 Hz) and low γ (25-70 Hz) postsynaptic oscillations in the infragranular layer, whereas in the supragranular layer, better correlations were found with high γ (70-170 Hz) oscillations. The time-frequency analysis of the postsynaptic potentials showed a transient broadband power increase in all layers after the stimulus onset that was followed by a sustained high γ oscillation in the supragranular layer, fluctuations in the laminar content of the low-frequency oscillations, and a global attenuation in the low-frequency powers after the stimulus offset that happened together with a long-lasting strengthening of the β oscillations. We concluded that, for rats, sounds are codified in A1 by segregated networks of specialized PCs whose postsynaptic activity impinges on the emergence of sparse/dense spiking patterns.
Gender differences in partial-volume corrected brain perfusion using brain MRI in healthy children. 査読有り

Taki Y, Hashizume H, Sassa Y, Takeuchi H, Wu K, Asano M, Asano K, Fukuda H, Kawashima R

NeuroImage　58　(3)　709-715　2011年10月

DOI： 10.1016/j.neuroimage.2011.07.020 　

ISSN：1053-8119
Second-language instinct and instruction effects: nature and nurture in second-language acquisition. 国際誌査読有り

Yusa N, Koizumi M, Kim J, Kimura N, Uchida S, Yokoyama S, Miura N, Kawashima R, Hagiwara H

Journal of cognitive neuroscience　23　(10)　2716-2730　2011年10月
出版者・発行元： 10
DOI： 10.1162/jocn.2011.21607 　

ISSN：0898-929X
Neural bases of a specific strategy for visuospatial processing in rugby players. 国際誌査読有り

Sekiguchi A, Yokoyama S, Kasahara S, Yomogida Y, Takeuchi H, Ogawa T, Taki Y, Niwa S, Kawashima R

Medicine and science in sports and exercise　43　(10)　1857-1862　2011年10月
出版者・発行元： 10
DOI： 10.1249/MSS.0b013e31821920f3 　

ISSN：1530-0315 0195-9131
Verbal working memory performance correlates with regional white matter structures in the frontoparietal regions. 査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

Neuropsychologia　49　(12)　3466-3473　2011年10月
出版者・発行元： 12
DOI： 10.1016/j.neuropsychologia.2011.08.022 　

ISSN：1873-3514 0028-3932
親子調理による子どもの認知機能の向上の研究 : 生活介入実験ならびに近赤外線計測実験

山下満智子, 川島隆太, 佐々祐子, 山本一恵, 高倉美香, 南貴美子, 大西徹也

日本食生活学会誌 = Journal for the integrated study of dietary habits　22　(2)　88-97　2011年9月30日
出版者・発行元： THE JAPAN ASSOCIATION FOR THE INTEGRATED STUDY OF DIETARY HABITS
DOI： 10.2740/jisdh.22.88 　

ISSN：1346-9770

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本研究は「親子で行う調理習慣が子どもの認知機能に良い影響を与える」ということを実証する目的で行った。 研究方法として, 親子調理による生活介入実験, ならびに近赤外線計測装置による親子調理中の脳活動の計測実験を行った。生活介入実験では, 29組の小学生とその親を, 介入群 (子ども16人, 平均年齢8. 9歳) と対照群 (子ども13人, 平均年齢8. 8歳) の二組に分け, 介入群に対して3ヶ月にわたり, 調理習慣導入のための生活介入を行った。介入前後の脳機能検査は, 8種の検査から構成した。脳機能検査の得点の変化についてpaired t-testを用いて統計的検定を行い, さらに前後の変化値の群間差の統計決定として, 検査ごとに分散分析を行った。計測実験では, 被験者である8人の子ども (平均年齢10. 3歳) は, 背外側前頭前野をカバーする頭部にプローブを装着し, ガスコンロを使ってホットケーキを焼き, 盛り付けるという調理中の脳活動の計測を行った。 その結果, 生活介入実験では, 調理の生活介入を行った子どもで, 概念課題において明らかに有意に検査値の上昇がみられた。さらに概念課題, 二次元回転課題の変化値の群間差に統計的な有意差が認められた。計測実験では, ホットケーキを焼く, 盛り付けるという各手順において, 全ての被験者の左右の大脳半球の背外側前頭前野の活性化が確認された。本研究では, 親子で行う調理習慣が子どもの認知機能に良い影響を与えることが実証された。 従来の知見や脳科学の先行研究, 本研究結果から, 親子で行う調理が子どものさまざまな脳機能を発達させる可能性があらためて示唆されたといえる。
Cerebral Blood Flow during Rest Associates with General Intelligence and Creativity 査読有り

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, Ryuta Kawashima

PLOS ONE　6　(9)　e25532　2011年9月

DOI： 10.1371/journal.pone.0025532 　

ISSN：1932-6203
Regional gray matter density associated with emotional intelligence: evidence from voxel-based morphometry. 査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

Human brain mapping　32　(9)　1497-1510　2011年9月
出版者・発行元： 9
DOI： 10.1002/hbm.21122 　

ISSN：1097-0193 1065-9471
Neural bases of human mate choice: Multiple value dimensions, sex difference, and self-assessment system. 査読有り

Funayama R, Sugiura M, Sassa Y, Jeong H, Wakusawa K, Horie K, Sato S, Kawashima R

Social neuroscience　7　(1)　59-73　2011年9月

DOI： 10.1080/17470919.2011.580120 　

ISSN：1747-0919
Changes in Neural Correlates of Outcome Feedback Processing During Implicit Learning 査読有り

M.Rostami, S.M.H.Hosseini, M.Takahashi, M.Sugiura, R.Kawashima

The Open Neuroscience Journal　5　24-30　2011年8月2日

DOI： 10.2174/1874082001105010024 　
Quantifying the uncertainty of spontaneous Ca2+ oscillations in astrocytes: Particulars of Alzheimer’s disease 査読有り

Riera J, Hatanaka R, Uchida T, Ozaki T, Kawashima R

Biophys J　101　(3)　554-564　2011年8月

DOI： 10.1016/j.bpj.2011.06.041 　

ISSN：0006-3495
Effects of Training of Processing Speed on Neural Systems 査読有り

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, Ryuta Kawashima

JOURNAL OF NEUROSCIENCE　31　(34)　12139-12148　2011年8月

DOI： 10.1523/JNEUROSCI.2948-11.2011 　

ISSN：0270-6474
The representation of social interaction in episodic memory: a functional MRI study. 査読有り

Mano Y, Sugiura M, Tsukiura T, Chiao JY, Yomogida Y, Jeong H, Sekiguchi A, Kawashima R

NeuroImage　57　(3)　1234-1242　2011年8月
出版者・発行元： 3
DOI： 10.1016/j.neuroimage.2011.05.016 　

ISSN：1053-8119
Correlation between degree of white matter hyperintensities and global gray matter volume decline rate 査読有り

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

NEURORADIOLOGY　53　(6)　397-403　2011年6月

DOI： 10.1007/s00234-010-0746-x 　

ISSN：0028-3940
A longitudinal study of gray matter volume decline with age and modifying factors 査読有り

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Ryuta Kawashima, Hiroshi Fukuda

NEUROBIOLOGY OF AGING　32　(5)　907-915　2011年5月

DOI： 10.1016/j.neurobiolaging.2009.05.003 　

ISSN：0197-4580
Neural Substrates of Decision Making in Irritable Bowel Syndrome 査読有り

Aizawa Emiko, Kochiyama Takanori, Sato Yasuhiro, Morishita Joe, Sekiguchi Atsushi, Kolnzaki Yuka, Kano Michiko, Kanazawa Motoyori, Sugiura Motoaki, Kawashima Ryuta, Mushiake Hajime, Fukudo Shin

GASTROENTEROLOGY　140　(5)　S365　2011年5月

ISSN：0016-5085
Self-face recognition in social context. 査読有り

Sugiura M, Sassa Y, Jeong H, Wakusawa K, Horie K, Sato S, Kawashima R

Human brain mapping　33　(6)　1364-1374　2011年5月

DOI： 10.1002/hbm.21290 　

ISSN：1065-9471
Decoding what one likes or dislikes from single-trial fNIRS measurements 査読有り

Hosseini S. M. Hadi, Mano Yoko, Rostami Maryam, Takahashi Makoto, Sugiura Motoaki, Kawashima Ryuta

NEUROREPORT　22　(6)　269-273　2011年4月20日

DOI： 10.1097/WNR.0b013e3283451f8f 　

ISSN：0959-4965
誘発反応の新しい概念 Time-frequency analysis

菅野彰剛, 川島隆太

医学検査　60　(4)　435-435　2011年4月
出版者・発行元： (一社)日本臨床衛生検査技師会
ISSN：0915-8669

eISSN：2188-5346
ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 滝靖之, Wu Kai, 木之村重男, 佐藤和則, 井上健太郎, 後藤了以, 岡田賢, 川島隆太

ナノ医工学年報　4　(1)　89-98　2011年3月
出版者・発行元：東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN：1882-4692
Correlation between gray/white matter volume and cognition in healthy elderly people 査読有り

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

BRAIN AND COGNITION　75　(2)　170-176　2011年3月

DOI： 10.1016/j.bandc.2010.11.008 　

ISSN：0278-2626
Failing to deactivate: the association between brain activity during a working memory task and creativity. 国際誌査読有り

Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R

NeuroImage　55　(2)　681-687　2011年3月

DOI： 10.1016/j.neuroimage.2010.11.052 　

ISSN：1053-8119
383人の健常成人の縦断研究による加齢及び脳血管障害危険因子と局所脳灰白質体積減少量との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, Wu Kai, 川島隆太, 福田寛

日本医学放射線学会学術集会抄録集　70回　S289-S289　2011年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：0048-0428

eISSN：1347-7951
A mini-cap for simultaneous EEG and fMRI recording in rodents 査読有り

Akira Sumiyoshi, Jorge J. Riera, Takeshi Ogawa, Ryuta Kawashima

NEUROIMAGE　54　(3)　1951-1965　2011年2月

DOI： 10.1016/j.neuroimage.2010.09.056 　

ISSN：1053-8119
皮肉や肯定的発話への返答のしかたと性格特性との関係

秋元頼孝, 宮澤志保, 杉浦元亮, 川島隆太

電子情報通信学会技術研究報告. HCS, ヒューマンコミュニケーション基礎　110　(383)　25-30　2011年1月14日
出版者・発行元：一般社団法人電子情報通信学会
ISSN：0913-5685

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皮肉や肯定的発話(ほめや感謝)に対して人々がどのように返答するのかを調べた。その結果、肯定的発話に対しては「謙遜する」「お礼を言う」「肯定する」「笑う」が、皮肉に対しては「あやまる」「苦笑する」が、誤解によるほめに対しては「否定する」「苦笑する」が主要な返答のしかたであることが明らかとなった。また、聞き手の性格特性と返答のしかたの関係についても調べられた。その結果、我々は文脈の違いにより返答のしかたを変化させており、また、性格特性が返答の選択に与える影響も文脈によって異なることが示唆された。
An in vivo MRI Template Set for Morphometry, Tissue Segmentation, and fMRI Localization in Rats. 国際誌査読有り

Pedro Antonio Valdés-Hernández, Akira Sumiyoshi, Hiroi Nonaka, Risa Haga, Eduardo Aubert-Vásquez, Takeshi Ogawa, Yasser Iturria-Medina, Jorge J Riera, Ryuta Kawashima

Frontiers in neuroinformatics　5　26-26　2011年

DOI： 10.3389/fninf.2011.00026 　

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Over the last decade, several papers have focused on the construction of highly detailed mouse high field magnetic resonance image (MRI) templates via non-linear registration to unbiased reference spaces, allowing for a variety of neuroimaging applications such as robust morphometric analyses. However, work in rats has only provided medium field MRI averages based on linear registration to biased spaces with the sole purpose of approximate functional MRI (fMRI) localization. This precludes any morphometric analysis in spite of the need of exploring in detail the neuroanatomical substrates of diseases in a recent advent of rat models. In this paper we present a new in vivo rat T2 MRI template set, comprising average images of both intensity and shape, obtained via non-linear registration. Also, unlike previous rat template sets, we include white and gray matter probabilistic segmentations, expanding its use to those applications demanding prior-based tissue segmentation, e.g., statistical parametric mapping (SPM) voxel-based morphometry. We also provide a preliminary digitalization of latest Paxinos and Watson atlas for anatomical and functional interpretations within the cerebral cortex. We confirmed that, like with previous templates, forepaw and hindpaw fMRI activations can be correctly localized in the expected atlas structure. To exemplify the use of our new MRI template set, were reported the volumes of brain tissues and cortical structures and probed their relationships with ontogenetic development. Other in vivo applications in the near future can be tensor-, deformation-, or voxel-based morphometry, morphological connectivity, and diffusion tensor-based anatomical connectivity. Our template set, freely available through the SPM extension website, could be an important tool for future longitudinal and/or functional extensive preclinical studies.
Increased activation of ventromedial prefrontal cortex during decision making in irritable bowel syndrome 査読有り

Aizawa Emiko, Kochiyama Takanori, Sato Yasuhiro, Morishita Joe, Sekiguchi Atsushi, Kotozaki Yuka, Miyazaki Atsushi, Kano Michiko, Kanazawa Motoyori, Sugiura Motoaki, Kawashima Ryuta, Mushiake Hajime, Fukudo Shin

NEUROSCIENCE RESEARCH　71　E370-E371　2011年

DOI： 10.1016/j.neures.2011.07.1627 　

ISSN：0168-0102
Correlation between baseline regional gray matter volume and global gray matter volume decline rate. 査読有り

Taki Y, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, Fukuda H

NeuroImage　54　(2)　743-749　2011年1月

DOI： 10.1016/j.neuroimage.2010.09.071 　

ISSN：1053-8119
Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals. 査読有り

Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Kawashima R, Fukuda H

PloS one　6　(7)　e22734　2011年

DOI： 10.1371/journal.pone.0022734 　
Residual visual function detected by visual evoked magnetic fields due to flash stimuli in minimally conscious state patients 査読有り

Kanno Akitake, Nakasato Nobukazu, Naganime Yoshihide, Kawashima Ryuta

NEUROSCIENCE RESEARCH　71　E77-E77　2011年

DOI： 10.1016/j.neures.2011.07.328 　

ISSN：0168-0102
外国語単語リーディングにおける母語の文字体系の影響:fMRI実験による検討

横山悟, 金情浩, 内田信也, 宮本正夫, 吉本啓, 川島隆太

日本認知科学会大会発表論文集(CD-ROM)　28th　ROMBUNNO.P2-2　2011年
Effects of aging on hippocampal and anterior temporal activations during successful retrieval of memory for face-name associations. 査読有り

Tsukiura T, Sekiguchi A, Yomogida Y, Nakagawa S, Shigemune Y, Kambara T, Akitsuki Y, Taki Y, Kawashima R

Journal of cognitive neuroscience　23　(1)　200-213　2011年1月
出版者・発行元： 1
DOI： 10.1162/jocn.2010.21476 　

ISSN：0898-929X 1530-8898

eISSN：1530-8898
Working memory training using mental calculation impacts regional gray matter of the frontal and parietal regions. 査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

PloS one　6　(8)　e23175　2011年
出版者・発行元： 8
DOI： 10.1371/journal.pone.0023175 　

ISSN：1932-6203
Testing second language oral proficiency in direct and semi-direct settings: a social-cognitive neuroscience perspective. 査読有り

Jeong H, Hashizume H, Sugiura M, Sassa Y, Yokoyama S, Shiozaki S, Kawashima R

Language Learning　61　(3)　675-699　2011年

DOI： 10.1111/j.1467-9922.2011.00635.x 　
An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats. 国際誌査読有り

Takakuni Goto, Rieko Hatanaka, Takeshi Ogawa, Akira Sumiyoshi, Jorge Riera, Ryuta Kawashima

Journal of neurophysiology　104　(6)　3388-412　2010年12月

DOI： 10.1152/jn.00122.2010 　

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Microelectrode arrays used to record local field potentials from the brain are being built with increasingly more spatial resolution, ranging from the initially developed laminar arrays to those with planar and three-dimensional (3D) formats. In parallel with such development in recording techniques, current source density (CSD) analyses have recently been expanded up to the continuous-3D form. Unfortunately, the effect of the conductivity profile on the CSD analysis performed with contemporary microelectrode arrays has not yet been evaluated and most of the studies assumed it was homogeneous and isotropic. In this study, we measured the conductivity profile in the somatosensory barrel cortex of Wistar rats. To that end, we combined multisite electrophysiological data recorded with a homemade assembly of silicon-based probes and a nonlinear least-squares algorithm that implicitly assumed that the cerebral cortex of rodents could be locally approximated as a layered anisotropic spherical volume conductor. The eccentricity of the six cortical layers in the somatosensory barrel cortex was evaluated from postmortem histological images. We provided evidence for the local spherical character of the entire barrels field, with concentric cortical layers. We found significant laminar dependencies in the conductivity values with radial/tangential anisotropies. These results were in agreement with the layer-dependent orientations of myelinated axons, but hardly related to densities of cells. Finally, we demonstrated through simulations that ignoring the real conductivity profile in the somatosensory barrel cortex of rats caused considerable errors in the CSD reconstruction, with pronounced effects on the continuous-3D form and charge-unbalanced CSD. We concluded that the conductivity profile must be included in future developments of CSD analysis, especially for rodents.
Breakfast staple types affect brain gray matter volume and cognitive function in healthy children 国際誌査読有り

Taki Y, Hashizume H, Thyreau B, Sassa Y, Takeuchi Y, Asano M, Asano K, Kotozaki Y, Nouchi R, Wu K, Fukuda H, Kawashima R

PloS one　5　(12)　e15213　2010年12月

DOI： 10.1371/journal.pone.0015213 　
脳波・筋電図の臨床遷延性意識障害例の聴性定常状態誘発磁界査読有り

菅野彰剛, 中里, 信和, 川瀬, 哲明, 長嶺, 義秀, 川島隆太

臨床脳波　52　(12)　719-723　2010年12月
出版者・発行元： (株)永井書店
ISSN：0485-1447
Right frontopolar cortex activity correlates with reliability of retrospective rating of confidence in short-term recognition memory performance. 国際誌査読有り

Yokoyama O, Miura N, Watanabe J, Takemoto A, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R, Nakamura K

Neuroscience research　68　(3)　199-206　2010年11月

DOI： 10.1016/j.neures.2010.07.2041 　

ISSN：0168-0102
Aging and decision making under uncertainty: Behavioral and neural evidence for the preservation of decision making in the absence of learning in old age 査読有り

S. M. Hadi Hosseini, Maryam Rostami, Yukihito Yomogida, Makoto Takahashi, Takashi Tsukiura, Ryuta Kawashima

NEUROIMAGE　52　(4)　1514-1520　2010年10月

DOI： 10.1016/j.neuroimage.2010.05.008 　

ISSN：1053-8119
Dissociable roles of the anterior temporal regions in successful encoding of memory for person identity information. 査読有り

Tsukiura T, Mano Y, Sekiguchi A, Yomogida Y, Hoshi K, Kambara T, Takeuchi H, Sugiura M, Kawashima R

Journal of cognitive neuroscience　22　(10)　2226-2237　2010年10月
出版者・発行元： 10
DOI： 10.1162/jocn.2009.21349 　

ISSN：0898-929X 1530-8898

eISSN：1530-8898
文理解中における脳活動の発達的変化

横山悟, 瀧靖之, 橋爪寛, 野澤孝之, 高橋慶, 川島隆太

電子情報通信学会技術研究報告　110　(163(TL2010 11-29))　19-24　2010年7月29日
出版者・発行元：社団法人電子情報通信学会
ISSN：0913-5685

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人間の脳は、形態的にも機能的にも、発達に伴って変化することが報告されてきている。しかしながら、文理解に関わる脳機能の発達的な変化については明らかになっていない。本研究では6歳から18歳までの健常小児114名を対象に、文理解中の脳活動の発達的変化がどのように見られるかについて調べるため、2文節から成るひらがな文を読む課題を行っているときの脳活動を、機能的磁気共鳴画像法(fMRI)を用いて撮像した。その結果、子どもの発達に伴う文理解における脳活動の変化に対して、(1)発達に伴い効率的に処理が行われるようになるにつれ、主に右半球における脳活動が低下していく、(2)発達的変化は男児にのみ強く見られ、女児にはあまり見られない、(3)12歳前後における発達に伴う転換点は見られない、ということが明らかになった。
Regional gray matter volume of dopaminergic system associate with creativity: evidence from voxel-based morphometry. 査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

NeuroImage　51　(2)　578-585　2010年6月
出版者・発行元： 2
DOI： 10.1016/j.neuroimage.2010.02.078 　

ISSN：1053-8119
How Can Brain Learn to Control a Nonholonomic System 査読有り

Noriyasu Homma, Shinpei Kato, Takakuni Goto, Ivo Bukovsky, Ryuta Kawashima, Makoto Yoshizawa

Journal of Robotics　2010　(919306)　1-7　2010年5月
【循環制御の基礎の進歩】循環制御機能をコントロールすることができる乗用車の可能性の展開査読有り

山家智之, 金野敏, 白石泰之, 劉紅煎, 川島隆太, 阿部恒之, 杉田典大, 吉沢誠, 関隆志

循環制御　30　(3)　127-141　2010年5月
White matter structures associated with creativity: evidence from diffusion tensor imaging. 査読有り

Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

NeuroImage　51　(1)　11-18　2010年5月
出版者・発行元： 1
DOI： 10.1016/j.neuroimage.2010.02.035 　

ISSN：1053-8119
Learning second language vocabulary: neural dissociation of situation-based learning and text-based learning. 査読有り

Jeong H, Sugiura M, Sassa Y, Wakusawa K, Horie K, Sato S, Kawashima R

NeuroImage　50　(2)　802-809　2010年4月
出版者・発行元： 2
DOI： 10.1016/j.neuroimage.2009.12.038 　

ISSN：1053-8119
ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 滝靖之, Wu Kai, 木之村重男, 佐藤和則, 井上健太郎, 後藤了以, 岡田賢, 川島隆太

ナノ医工学年報　3　(1)　93-102　2010年3月
出版者・発行元：東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN：1882-4692
Concurrent observations of astrocytic Ca2+ activity and multisite extracellular potentials from an intact cerebral cortex 査読有り

Jorge Riera, Takeshi Ogawa, Rieko Hatanaka, Takakuni Goto, Akira Sumiyoshi, Herve Enjieu Kadji, Sakura Nakauchi, Ryuta Kawashima

JOURNAL OF BIOPHOTONICS　3　(3)　147-160　2010年3月

DOI： 10.1002/jbio.200910036 　

ISSN：1864-063X
The neural basis of agency: an fMRI study. 査読有り

Yomogida Y, Sugiura M, Sassa Y, Wakusawa K, Sekiguchi A, Fukushima A, Takeuchi H, Horie K, Sato S, Kawashima R

NeuroImage　50　(1)　198-207　2010年3月
出版者・発行元： 1
DOI： 10.1016/j.neuroimage.2009.12.054 　

ISSN：1053-8119
Training of working memory impacts structural connectivity. 査読有り

Takeuchi H, Sekiguchi A, Taki Y, Yokoyama S, Yomogida Y, Komuro N, Yamanouchi T, Suzuki S, Kawashima R

The Journal of neuroscience : the official journal of the Society for Neuroscience　30　(9)　3297-3303　2010年3月
出版者・発行元： 9
DOI： 10.1523/JNEUROSCI.4611-09.2010 　

ISSN：1529-2401 0270-6474
診断治療機能を保持する自動車の可能性査読有り

山家智之, 金野敏, 白石泰之, 川島隆太, 阿部恒之, 杉田典大, 吉沢誠, 関隆志

日本臨床生理学会雑誌　40　(1)　5-14　2010年2月
Pitfalls in the dipolar model of the neocortical EEG sources

Jorge Riera, Takeshi Ogawa, Takakuni Goto, Akira Sumiyoshi, Hiroi Nonaka, Alan Evans, Ryuta Kawashima

APSIPA ASC 2010 - Asia-Pacific Signal and Information Processing Association Annual Summit and Conference　964-968　2010年
Age-related differences in brain activity during successful encoding of memory for person identity information 査読有り

Takashi Tsukiura, Yayoi Shigemune, Toshimune Kambara, Atsushi Sekiguchi, Yukihito Yomogida, Seishu Nakagawa, Yuko Akitsuki, Yasuyuki Taki, Ryuta Kawashima

NEUROSCIENCE RESEARCH　68　E300-E300　2010年

DOI： 10.1016/j.neures.2010.07.1334 　

ISSN：0168-0102
Age-dependency in brain activation involved with imitation of unfamiliar foreign language sound: an fMRI study 査読有り

Hashizume Hiroshi, Taki Yasuyuki, Sassa Yuko, Asano Michiko, Asano Kohei, Takeuchi Hikaru, Jeong Hyeonjeong, Sugiura Motoaki, Kawashima Ryuta

NEUROSCIENCE RESEARCH　68　E300-E301　2010年

DOI： 10.1016/j.neures.2010.07.1335 　

ISSN：0168-0102
Functional anatomy of visuosocial processing in temporo-parietal region 査読有り

Sugiura Motoaki, Yomogida Yukihito, Mano Yoko, Sassa Yuko, Kambara Toshimune, Sekiguchi Atsushi, Kawashima Ryuta

NEUROSCIENCE RESEARCH　68　E415　2010年

DOI： 10.1016/j.neures.2010.07.1840 　

ISSN：0168-0102
Effects of working memory training on cognitive functions and neural systems. 査読有り

Takeuchi H, Taki Y, Kawashima R

Reviews in the neurosciences　21　(6)　427-449　2010年

ISSN：0334-1763
Effect of motion smoothness on brain activity while observing a dance: An fMRI study using a humanoid robot. 国際誌査読有り

Miura N, Sugiura M, Takahashi M, Sassa Y, Miyamoto A, Sato S, Horie K, Nakamura K, Kawashima R

Social neuroscience　5　(1)　40-58　2010年

DOI： 10.1080/17470910903083256 　

ISSN：1747-0919
Human brain activities related to manual control of a nonholonomic system 査読有り

Noriyasu Homma, Shinpei Kato, Takakuni Goto, Masao Sasaki, Norihiro Sugita, Makoto Yoshizawa, Yukihito Yomogida, Yuko Sassa, Motoaki Sugiura, Jorge Reira, Ryuta Kawashima

International Journal of Advanced Computer Engineering　2　(2)　129-133　2009年12月
Analyzing control-display movement compatibility: A neuroimaging study 査読有り

S. M.Hadi Hosseini, Maryam Rostami, Makoto Takahashi, Naoki Miura, Motoaki Sugiura, Ryuta Kawashima

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)　5639 LNAI　187-196　2009年12月1日

DOI： 10.1007/978-3-642-02728-4_20 　

ISSN：0302-9743
脳機能画像データを用いた英語学習者のリーディング習熟度評価(言語と学習,場の共創)

横山悟, スシライプト, 大澤剛士, 川島隆太

電子情報通信学会技術研究報告. TL, 思考と言語　109　(297)　57-62　2009年11月14日
出版者・発行元：社団法人電子情報通信学会
ISSN：0913-5685

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今までの言語習熟度評価は、被験者の言語処理後の回答結果から行っていた。本研究では、被験者の回答中の脳活動データを援用することで、より精度の高い習熟度評価システムの開発を目指すことが最終目的である。本発表では、日本人の英語学習者による英文読解時の脳活動データを用いて、学習者の習熟度評価がどの程度可能かを検証した結果を報告する。
Neural correlates of processing situational relationships between a part and the whole: an fMRI study. 査読有り

Wakusawa K, Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, Yokoyama H, Tsuchiya S, Kawashima R

NeuroImage　48　(2)　486-496　2009年11月
出版者・発行元： 2
DOI： 10.1016/j.neuroimage.2009.06.024 　

ISSN：1053-8119
Anatomical Segregation of Representations of Personally Familiar and Famous People in the Temporal and Parietal Cortices 査読有り

Motoaki Sugiura, Yuko Sassa, Jobu Watanabe, Yuko Akitsuki, Yasuhiro Maeda, Yoshihiko Matsue, Ryuta Kawashima

JOURNAL OF COGNITIVE NEUROSCIENCE　21　(10)　1855-1868　2009年10月

DOI： 10.1162/jocn.2008.21150 　

ISSN：0898-929X
Cortical areas related to performance of WAIS Digit Symbol Test: a functional imaging study. 査読有り

Usui Nobuo, Haji Tomoki, Maruyama Masakazu, Katsuyama Narumi, Uchida Shinya, Hozawa Atsushi, Omori Kahoru, Tsuji Ichiro, Kawashima Ryuta, Taira Masato

Neurosci Lett　463　(1)　1-5　2009年9月29日

DOI： 10.1016/j.neulet.2009.07.048 　
Left Middle Temporal Deactivation Caused by Insufficient Second Language Word Comprehension by Chinese-Japanese Bilinguals 査読有り

Satoru Yokoyama, Tadao Miyamoto, Jungho Kim, Noriaki Yusa, Kei Yoshimoto, Ryuta Kawashima

Journal of Neurolinguistics　22　(5)　495-513　2009年9月

DOI： 10.1016/j.jneuroling.2009.04.002 　
Neural activity in the human brain signals logical rule identification 国際誌査読有り

Kaori Tachibana, Kyoko Suzuki, Etsuro Mori, Naoki Miura, Ryuta Kawashima, Kaoru Horie, Shigeru Sato, Jun Tanji, Hajime Mushiake

Journal of Neurophysiology　102　(3)　1526-1537　2009年9月1日

DOI： 10.1152/jn.90659.2008 　

ISSN：0022-3077
Extraction of situational meaning by integrating multiple meanings in a complex environment: a functional MRI study. 査読有り

Sugiura M, Wakusawa K, Sekiguchi A, Sassa Y, Jeong H, Horie K, Sato S, Kawashima R

Human brain mapping　30　(8)　2676-2688　2009年8月
出版者・発行元： 8
DOI： 10.1002/hbm.20699 　

ISSN：1065-9471
Neural bases of goal-directed implicit learning 査読有り

Maryam Rostami, S.M.Hadi Hosseini, Makoto Takahashi, Motoaki Sugiura, Ryuta Kawashima

NeuroImage　48　303-310　2009年6月

DOI： 10.1016/j.neuroimage.2009.06.007 　
計器監視におけるインタフェースの差異と難易度の関連性解析 : 機能的MRIを用いた脳機能計測研究査読有り

三浦直樹, 高橋信, 川島隆太, 北村正晴, 若林利男

ヒューマンインタフェース学会論文誌　11　(2)　193-202　2009年5月25日
出版者・発行元：ヒューマンインタフェース学会
ISSN：1344-7262
Learning Effect of L2 Words in Non-Fluent Second Language Learners: An FMRI Study 査読有り

Satoru Yokoyama, Tadao Miyamoto, Jungho Kim, Shin-ya Uchida, Kei Yoshimoto, Ryuta Kawashima

Second Languages: Teaching, Learning and Assessment, Nova Science Publishers　147-156　2009年4月
Neural basis of sentence processing in which incoming words form a sentence 査読有り

Ikuta Naho, Sugiura Motoaki, Inoue Kentaro, Sato Shigeru, Horie Kaoru, Kawashima Ryuta

NEUROREPORT　20　(5)　531-535　2009年3月25日

DOI： 10.1097/WNR.0b013e3283294061 　

ISSN：0959-4965
ヒト脳の正常加齢およびその危険因子の解明健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 滝靖之, Wu Kai, 木之村重男, 佐藤和則, 井上健太郎, 後藤了以, 岡田賢, 川島隆太

ナノ医工学年報　2　(1)　89-97　2009年3月
出版者・発行元：東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN：1882-4692
Scrambling effects on the processing of Japanese sentences: An fMRI study 査読有り

Kim, Jungho, Masatoshi Koizumi, Naho Ikuta, Yuichiro Fukumitsu, Naoki Kimura, Kazuki Iwata, Jobu Watanabe, Satoru Yokoyama, Shigeru Sato, Kaoru Horie, Ryuta Kawashima

Journal of Neurolinguistics　22　151-166　2009年3月

DOI： 10.1016/j.jneuroling.2008.07.005 　
年齢相応の脳発達とは?

瀧靖之, 橋爪寛, 佐々祐子, 木之村重男, 後藤了以, 佐藤和則, 福田寛, 川島隆太

日本医学放射線学会学術集会抄録集　68回　S274-S274　2009年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：0048-0428

eISSN：1347-7951
Normal Brain Aging and its Risk Factors - Analysis of Brain Magnetic Resonance Image (MRI) Database of Healthy Japanese Subjects 査読有り

H. Fukuda, Y. Taki, K. Sato, S. Kinomura, R. Goteau, R. Kawashima

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2228-+　2009年

ISSN：1680-0737
Social interaction and concern for others in episodic memory: an fMRI study 査読有り

Yoko Mano, Motoaki Sugiura, Takashi Tsukiura, Yukihito Yomogida, Hyeonjeong Jeong, Atsushi Sekiguchi, Yuko Akitsuki, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S244-S244　2009年

DOI： 10.1016/j.neures.2009.09.1383 　

ISSN：0168-0102
A NIRS-based Brain-Computer Interface System during Motor Imagery: System Development and Online Feedback Training

Shin'ichiro Kanoh, Yu-mi Murayama, Ko-ichiro Miyamoto, Tatsuo Yoshinobu, Ryuta Kawashima

2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20　594-+　2009年

DOI： 10.1109/IEMBS.2009.5333710 　

ISSN：1557-170X
Neural basis of episode context: an fMRI study 査読有り

Sugiura Motoaki, Yomogida Yukihito, Kambara Toshimune, Mano Yoko, Sekiguchi Atsushi, Tsukiura Takashi, Kawashima Ryuta

NEUROSCIENCE RESEARCH　65　S236　2009年

DOI： 10.1016/j.neures.2009.09.1330 　

ISSN：0168-0102
Neuro-physiological evidence of linguistic empathy processing in the human brain: a functional magnetic resonance imaging study. 査読有り

Satoru Yokoyama, Kei Yoshimoto, Tadao Miyamoto, Ryuta Kawashima

Journal of Neurolinguistics　2009年

DOI： 10.1016/j.jneuroling.2009.07.002 　
Somatotopical relationships between cortical activity and reflex areas in reflexology: A functional magnetic resonance imaging study 査読有り

Tomomi Nakamaru, Naoki Miura, Ai Fukushima, Ryuta Kawashima

Neuroscience Letters　448　(1)　6-9　2008年12月19日
出版者・発行元： Elsevier Ireland Ltd.
DOI： 10.1016/j.neulet.2008.10.022 　

ISSN：0304-3940
Human Cortical Anatomical Networks Assessed by Structural MRI 査読有り

A. C. Evans, J. M. Lee, S. I. Kim, H. Fukuda, R. Kawashima, Y. He, T. Jiang, J. S. Kim, Z. Chen, K. Im, O. Lyttelton, J. Lerch, V. Singh, K. Sato, Y. Taki, R. Goto, S. Kinomura, K. Mok, J. K. Lee, U. Yoon

BRAIN IMAGING AND BEHAVIOR　2　(4)　289-299　2008年12月

DOI： 10.1007/s11682-008-9034-3 　

ISSN：1931-7557

eISSN：1931-7565
Neural substrates of the Topology Test to measure fluid reasoning: An fMRI study 査読有り

Hiromi Masuinaga, Ryuta Kawashima, John L. Horn, Yuko Sassa, Atsushi Sekiguchi

INTELLIGENCE　36　(6)　607-615　2008年11月

DOI： 10.1016/j.intell.2008.01.006 　

ISSN：0160-2896
F-MRI analysis of the human brain activities during manual control of a nonholonomic system 査読有り

Shinpei Kato, Takakuni Goto, Noriyasu Homma, Makoto Yoshizawa, Yukihito Yomogida, Yuko Sassa, Motoaki Sugiura, Jorge Riera, Ryuta Kawashima

Proc. SICE 2008　1977-1980　2008年8月
文理解における脳内情報抽出メカニズムの解明(人間の日本語文理解・産出)

高橋慶, 横山悟, 神原利宗, 吉本啓, 川島隆太

電子情報通信学会技術研究報告. TL, 思考と言語　108　(184)　11-15　2008年8月1日
出版者・発行元：社団法人電子情報通信学会
ISSN：0913-5685

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本研究の目的は,人間の文理解に関わる脳内の情報抽出メカニズムの解明である.そこで,fMRIを用い,後述する,文字,単語,文課題遂行中の脳活動を計測した.被験者に,提示した2セットの文字・単語を覚え,その後提示した文字・単語が含まれていたのが前半であったか後半であったかを判断させた.文課題については,不適格な等位接続文を用い,どちらのconjunctに不適格な要素が含まれているかを判断させた.実験の結果,文課題のみ左中前頭回で有意な脳活動がみられた.このことから,文理解に関わる言語情報抽出は,音韻,単語情報保持とは異なる神経基盤が担っていると言える.
文理解を支える下位処理間の関係性(人間の日本語文理解・産出)

横山悟, 川島隆太

電子情報通信学会技術研究報告. TL, 思考と言語　108　(184)　5-10　2008年8月1日
出版者・発行元：社団法人電子情報通信学会
ISSN：0913-5685

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文を理解するには、複数の下位処理が必要とされると考えられている。たとえば、音韻情報から単語を認知するには音韻情報を一時的に記憶しておかなければならない。また、単語が認知できたら、文としての意味を理解するために複数の単語を一時的に記憶しておかなければならない。本論文では、上記のような文理解に関わる下位処理を担う脳内神経基盤が、どのように関係しながら文理解という高次の認知処理を行っているのかについて議論する。
Face-specific and domain-general characteristics of cortical responses during self-recognition 査読有り

Motoaki Sugiura, Yuko Sassa, Hyeonjeong Jeong, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

NEUROIMAGE　42　(1)　414-422　2008年8月

DOI： 10.1016/j.neuroimage.2008.03.054 　

ISSN：1053-8119
A Decay Effect in Real-time Sentence Processing 査読有り

Kei Takahashi, Satoru Yokoyama, Toshimune Kambara, Kei Yoshimoto, Ryuta Kawashima

Proceedings of the 6th International Conference of Cognitive Science　218-221　2008年7月
高英語力大学生群における逐次通訳時の脳活性―fMRI実験の結果から査読有り

辰巳桂子, 出口弘, 長尾ひろみ, 杉浦元亮, JEONG Hyeonjeong, 生田奈穂, 橋爪寛, 松縄順子, 川島隆太

神戸女学院大学論集　55　(1)　89-104　2008年6月
出版者・発行元：神戸女学院大学
DOI： 10.18878/00001856 　

ISSN：0389-1658

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One of human-being specific activities, interpreting (oral translation), has been adopted as a popular method to enhance second language acquisition lately. The question, however, how interpreting is executed in human brains, remains largely unknown. In this paper, we present our fMRI (functional Magnetic Resonance Imaging) experimental results to investigate how cerebral cortices are activated when subjects are engaged in interpreting exercises. Twenty-one healthy, right-handed university student subjects participated in this study. We directly compared English to Japanese consecutive interpreting (EJ) to Japanese to English consecutive interpreting (JE) using subtraction method, as well as with sentence reconstruction tasks in Japanese (JJ) and English (EE), and with resting condition (Rest, or baseline). The direct subtraction analysis between EJ and JE left only a limited area: left superior temporal gyrus remained. In JE minus EJ (masked by EJ-Rest: P<0.05image), right and left precentral gyri, left thalamus, left and right superior temporal gyri, and left middle temporal gyrus are left, suggesting that JE recruited more extensive regions in comparison with EJ, despite that all sources of sentence recorded and used as stimuli were constructed to be at the same level of difficulty, either directly taken from MEXT (Ministry of Education, Culture, Sports, Science and Technology) -authorized popular textbooks used in Japanese public junior high schools, or translation of such sources. The conditions EJ, EE, and JJ showed very similar patterns of cortical activation, indicating that the conditions recruited similar brain regions: left and right superior temporal gyri, mainly left middle temporal gyrus,, left inferior frontal gyrus (opercular part and triangular part), left temporal lobe's lateral surface, and mainly left supplementary motor areas. EJ and JE commonly activated Inferior frontal gyri (opercular part and triangular part) and supplementary motor areas in both hemispheres. Kawashima (2004) reports that even a different-activity-related cortical activation serves as a preparatory activity for the individuals' following activity and enhances learning or delays development of dementia in older subjects. From the results, we infer that EE and JJ sentence reconstruction exercises that activated similar regions to those activated in consecutive interpreting might fit the purpose of consecutive interpreting training preparation.
Electromagnetic source imaging: Backus-Gilbert resolution spread function-constrained and functional MRI-guided spatial filtering 査読有り

Xiaohong Wan, Atsushi Sekiguchi, Satoru Yokoyama, Jorge Riera, Ryuta Kawashima

HUMAN BRAIN MAPPING　29　(6)　627-643　2008年6月

DOI： 10.1002/hbm.20424 　

ISSN：1065-9471
Decrease in glucose metabolism in frontal cortex associated with deterioration of microstructure of corpus callosum measured by diffusion tensor imaging in healthy elderly 査読有り

Kentaro Inoue, Hiroshi Ito, Shinya Uchida, Yasuyuki Taki, Shigeo Kinomura, Ichiro Tsuji, Shigeru Sato, Kaoru Horie, Ryuta Kawashima, Masatoshi Ito, Hiroshi Fukuda

HUMAN BRAIN MAPPING　29　(4)　375-384　2008年4月

DOI： 10.1002/hbm.20394 　

ISSN：1065-9471
文処理における容認性と語順の関係査読有り

高橋慶, 横山悟, 神原利宗, 吉本啓, 川島隆太

言語処理学会第14回年次大会発表論文集　2008年3月
Reading and solving arithmetic problems improves cognitive functions of normal aged people: a randomized controlled study 査読有り

Shinya Uchida, Ryuta Kawashima

AGE　30　(1)　21-29　2008年3月

DOI： 10.1007/s11357-007-9044-x 　

ISSN：0161-9152
加齢による灰白質体積の減少は男性が女性よりも早い 382人の脳MRI解析による縦断研究

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会学術集会抄録集　67回　S245-S245　2008年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：0048-0428

eISSN：1347-7951
ヒトの外側前頭前野は心理社会的成熟に関与する—他者の意思決定の理解についてのfMRI研究

立花良之, 杉浦元亮, 佐々祐子, 川島隆太

日本生理学会大会発表要旨集　2008　(0)　30-30　2008年
出版者・発行元：日本生理学会

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The purpose of this study was to identify the neural correlates of psychosocial maturity during understanding others from the viewpoint of self. In psychology, ego identity is one of the most famous theories for psychosocial maturity. Those who have established ego identity have a definite purpose for one's life and an ability of goal directed behavior. We assumed that such a psychosocial maturity is related to the ability to distinguish others from self when one understands the others. We used an fMRI technique to identify cortical regions where activity during understanding others' decision-making is correlated with personality maturity. We measured subjects' personality maturity using the Rasmussen's Ego Identity Scale. There were three conditions, S, F and G which were perspective taking conditions for inferring self, best friend and people in general's decision-making, respectively. Differential activation of both the contrasts F-S and G-S was significantly correlated with the ego identity scale in the left lateral prefrontal cortex (LPFC). The results indicate that the activity of the left LPFC is related to psychosocial maturity when understanding others from the viewpoint of self. We suggest that psychosocial maturity is related to the development of the executive function which is supported by the left LPFC. [J Physiol Sci. 2008;58 Suppl:S30]
How intellectual excitement enhances encoding of novel information? 査読有り

Ai Fukushima, Sugiura Motoaki, Sassa Yuko, Kawashima Ryuta

NEUROSCIENCE RESEARCH　61　S115　2008年

ISSN：0168-0102
Cortical mechanism of knowledge-based monitoring and intention-based monitoring 査読有り

Yomogida Yukihito, Sugiura Motoaki, Sasse Yuko, Wakusawa Keisuke, Sekiguchi Atsushi, Fukushima At, Takeuchi Hikaru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　61　S118　2008年

ISSN：0168-0102
Imitation of unfamiliar foreign language sound: An fMRI study 査読有り

Hashizume Hiroshi, Jeong Hyeonjeong, Ikuta Naho, Sugiura Motoaki, Kawashima Ryuta

NEUROSCIENCE RESEARCH　61　S199　2008年

ISSN：0168-0102
Roles of the medial orbitofrontal cortices (mOFC) and the nucleus accumbens (NAcc) in reward processing under passive situation 査読有り

Sekiguchi Atsushi, Sugiura Motoaki, Ikuta Naha, Kawashima Ryuta

NEUROSCIENCE RESEARCH　61　S280　2008年

ISSN：0168-0102
Relationship between body mass index and gray matter volume in 1,428 healthy individuals 査読有り

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Kentaro Inoue, Ryoi Goto, Ken Okada, Shinya Uchida, Ryuta Kawashima, Hiroshi Fukuda

OBESITY　16　(1)　119-124　2008年1月

DOI： 10.1038/oby.2007.4 　

ISSN：1930-7381
An advantage of bipedal humanoid robot on the empathy generation: a neuroimaging study 査読有り

Naoki Miura, Motoaki Sugiura, Makoto Takahashi, Tomohisa Moridaira, Atsushi Miyamoto, Yoshihiro Kuroki, Ryuta Kawashima

2008 IEEE/RSJ INTERNATIONAL CONFERENCE ON ROBOTS AND INTELLIGENT SYSTEMS, VOLS 1-3, CONFERENCE PROCEEDINGS　2465-+　2008年

DOI： 10.1109/IROS.2008.4650603 　
Processing of Anomalous Sentences in Japanese : An fMRI Study

Yuko Sassa, Motoaki Sugiura, Yoshihiko Matsue, Yuko Akitsuki, Yasuhiro Maeda, Ryuta Kawashima, Jobu Watanabe

Journal of Cognitive Science　8　(2)　153-170　2007年12月
出版者・発行元： Institute for Cognitive Science
DOI： 10.17791/jcs.2007.8.2.153 　

ISSN：1598-2327
外国語学習者の言語能力評価における脳機能データの応用(言語の学習・教育)

横山悟, 吉本啓, 川島隆太

電子情報通信学会技術研究報告. TL, 思考と言語　107　(323)　37-40　2007年11月9日
出版者・発行元：社団法人電子情報通信学会
ISSN：0913-5685

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本論文では、脳機能画像データを、外国語学習者の学習言語に対する習熟度評価に応用できるのではないかということを提案する。脳機能画像法は、ある課題を行っている時の脳活動を画像化できる。よって、外国語学習者における特定の言語課題中の脳内表象データベースを構築することにより、ある学習者がある処理をきちんと行えているかどうかについて、学習者の脳内反応から評価が可能であると考える。このようなデータベースにより、例えばある新たな学習方法による効果があったか否かについて、より正確な評価を行えるようになる。
Comprehension of implicit meanings in social situations involving irony: a functional MRI study. 査読有り

Wakusawa K, Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, Yokoyama H, Tsuchiya S, Inuma K, Kawashima R

NeuroImage　37　(4)　1417-1426　2007年10月1日

DOI： 10.1016/j.neuroimage.2007.06.013 　

ISSN：1053-8119
Body Mass Indexと全脳及び局所灰白質量との相関 1428人の脳MR画像を用いたvoxel-based morphometryによる解析

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 川島隆太

日本医学放射線学会秋季臨床大会抄録集　43回　S459-S459　2007年9月
出版者・発行元： (公社)日本医学放射線学会
ISSN：0048-0428

eISSN：1347-7951
Cortical mechanism of communicative speech production. 査読有り

Sassa Y, Sugiura M, Jeong H, Horie K, Sato S, Kawashima R

NeuroImage　37　985-992　2007年9月
出版者・発行元： 3
DOI： 10.1016/j.neuroimage.2007.05.059 　

ISSN：1053-8119
Working memory system as a sentence processor in the human brain 査読有り

Satoru Yokoyama, Kei Takahashi, Toshimune Kambara, Tadao Miyamoto, Kei Yoshimoto, Ryuta Kawashima

電子情報通信学会思考と言語研究会 (TL)７月研究会　2007年7月
Cross-linguistic influence on brain activation during second language processing: An fMRI study 査読有り

Hyeonjeong Jeong, Motoaki Sugiura, Yuko Sassa, Satoru Yokoyama, Kaoru Horie, Shigeru Sato, Masato Taira, Ryuta Kawashima

BILINGUALISM-LANGUAGE AND COGNITION　10　(2)　175-187　2007年7月

DOI： 10.1017/S1366728907002921 　

ISSN：1366-7289
Thematic Difficulty Causes Processing Cost for Sentence Comprehension 査読有り

Satoru Yokoyama, Masatoshi Koizumi, Jungho Kim, Noriaki Yusa, Kei Yoshimoto, Ryuta Kawashima

Proceedings of the European Cognitive Science Conference 2007　915　2007年5月
Cognitive rehabilitation - The learning therapy for the senile dementia 査読有り

Atsushi Sekiguchi, Ryuta Kawashima

Brain and Nerve　59　(4)　357-365　2007年4月

ISSN：0006-8969
[Cognitive rehabilitation--the learning therapy for the senile dementia]. 査読有り

Sekiguchi A, Kawashima R

Brain and nerve = Shinkei kenkyu no shinpo　59　(4)　357-365　2007年4月
出版者・発行元： 4
ISSN：1881-6096
Is Broca's area involved in the processing of passive sentences? An event-related fMRI study. 査読有り

Yokoyama S, Watanabe J, Iwata K, Ikuta N, Haji T, Usui N, Taira M, Miyamoto T, Nakamura W, Sato S, Horie K, Kawashima R

Neuropsychologia　45　989-996　2007年3月
出版者・発行元： 5
DOI： 10.1016/j.neuropsychologia.2006.09.003 　

ISSN：0028-3932
Effect of syntactic similarity on cortical activation during second language processing: a comparison of English and Japanese among native Korean trilinguals. 査読有り

Jeong H, Sugiura M, Sassa Y, Haji T, Usui N, Taira M, Horie K, Sato S, Kawashima R

Human brain mapping　28　(3)　194-204　2007年3月

DOI： 10.1002/hbm.20269 　

ISSN：1065-9471
加齢に伴う脳灰白質体積の経時変化健常被験者の脳MRI解析による8年間の縦断研究(第一報)

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会学術集会抄録集　66回　S187-S187　2007年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：0048-0428

eISSN：1347-7951
Brain activities related to inferring familiar and unfamiliar persons' decision-makings: An fMRI study 査読有り

Tachibana Yoshiyuki, Sassa Yuko, Yokoyama Satoru, Sugiura Motoaki, Kawashima Ryuta

NEUROSCIENCE RESEARCH　58　S62　2007年

DOI： 10.1016/j.neures.2007.06.366 　

ISSN：0168-0102
Cortical mechanism of positive self-concept: An fMRI study 査読有り

Fukushima Ai, Sugiura Motoaki, Miura Naoki, Uchida Shinya, Sekiguchi Atsushi, Horie Kaoru, Satoh Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　58　S115　2007年

DOI： 10.1016/j.neures.2007.06.1241 　

ISSN：0168-0102
The right temporal region contributes to the self-prospective direction of stress coping style 査読有り

Sekiguchi Atsushi, Sugiura Motoaki, Yokoyama Satoru, Kanbara Toshimune, Ikuta Naho, Satou Shigeru, Horie Kaoru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　58　S232　2007年

DOI： 10.1016/j.neures.2007.06.536 　

ISSN：0168-0102
An fMRI study: Processing of item-situation relationship 査読有り

Wakusawa Keisuke, Sugiura Motoaki, Sassa Yuko, eong Hyeanjeong, Horie Kaoru, Sato Shigeru, Yokoyama Hiroyuki, Tsuchiya Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　58　S233　2007年

DOI： 10.1016/j.neures.2007.06.541 　

ISSN：0168-0102
日本語の脳内における統語処理と語彙意味処理のfMRI 研究査読有り

神原利宗, 横山悟, 生田奈穂, ジョン-ヒョンジョン, 高橋慶, 関口敦, 宮本正夫, 高橋大厚, 小泉政利, 吉本啓, 堀江薫, 佐藤滋, 川島隆太

日本認知科学会第24回大会発表論文集　160-165　2007年
Who is to marry or to be a friend? An fMRI study of social decision-making 査読有り

Sugiura Motoaki, Funayama Risa, Sassa Yuko, Jeong Hyeonjeong, Wakusawa Keisuke, Tachibana Yoshiyuki, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　58　S64　2007年

DOI： 10.1016/j.neures.2007.06.375 　

ISSN：0168-0102
Two distinct neural networks for semantic access during visual word recognition 査読有り

Jeong Hyeonjeong, Sugiura Motoaki, Sassa Yuko, Miyamoto Tadao, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　58　S173　2007年

DOI： 10.1016/j.neures.2007.06.739 　

ISSN：0168-0102
Reanalysis in Japanese sentence comprehension: An fMRI study 査読有り

Ikuta Naho, Yokoyama Satoru, Jeong Hyeonjeong, Sugiura Motoaki, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　58　S174　2007年

DOI： 10.1016/j.neures.2007.06.745 　

ISSN：0168-0102
Multiple brain networks for visual self-recognition with different sensitivity for motion and body part. 査読有り

Sugiura M, Sassa Y, Jeong H, Miura N, Akitsuki Y, Horie K, Sato S, Kawashima R

NeuroImage　32　1905-1917　2006年10月
出版者・発行元： 4
DOI： 10.1016/j.neuroimage.2006.05.026 　

ISSN：1053-8119
大脳、小脳の各解剖学的構造における局所灰白質量と年齢との相関 1460人の脳MRIを用いたROI解析

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 小野修一, 川島隆太

日本医学放射線学会秋季臨床大会抄録集　42回　S455-S455　2006年9月
出版者・発行元： (公社)日本医学放射線学会
ISSN：0048-0428

eISSN：1347-7951
事象関連電位で見る名詞と助数詞の照合プロセス : 意味的処理か文法的処理か

酒井由美, 岩田一樹, リエラホルヘ, 万小紅, 横山悟, 下田由輝, 川島隆太, 吉本啓, 小泉政利

認知科学 = Cognitive studies : bulletin of the Japanese Cognitive Science Society　13　(3)　443-454　2006年9月1日
出版者・発行元：日本認知科学会
DOI： 10.11225/jcss.13.443 　

ISSN：1341-7924

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A numeral quantifier in Japanese consists of a numeral and a classifier that agrees with the type of entity being counted. In this study we investigated, using event-related potentials, brain activities associated with the integration of a numeral classifier and a noun that denotes an entity&frasl;entities being counted. Based on previous studies, we considered two hypotheses. If semantic processes are crucially involved in the integration of a noun and a numeral classifier, like selectional restriction between a verb and its object, N400 would be found when subjects read incorrect pairs of a noun and a numeral classifier. On the other hand, if the integration of a noun and a numeral classifier is morpho-syntactic in nature, parallel to gender agreement in European languages, then LAN would be elicited. Results of our experiment showed that mismatch of a noun and a numeral classifier evoked N400. This suggests that a numeral classifier in Japanese semantically selects a noun denoting a certain type of entity.
Cortical mechanisms involved in the processing of verbs: an fMRI study. 査読有り

Yokoyama S, Miyamoto T, Riera J, Kim J, Akitsuki Y, Iwata K, Yoshimoto K, Horie K, Sato S, Kawashima R

Journal of cognitive neuroscience　18　1304-1313　2006年8月
出版者・発行元： 8
DOI： 10.1162/jocn.2006.18.8.1304 　

ISSN：0898-929X
Cortical mechanisms of person representation: recognition of famous and personally familiar names. 査読有り

Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Maeda Y, Matsue Y, Fukuda H, Kawashima R

NeuroImage　31　(2)　853-860　2006年6月

DOI： 10.1016/j.neuroimage.2006.01.002 　

ISSN：1053-8119
The neural basis of the hemodynamic response nonlinearity in human primary visual cortex: Implications for neurovascular coupling mechanism 招待有り査読有り

Xiaohong Wan, Jorge Riera, Kazuki Iwata, Makoto Takahashi, Toshio Wakabayashi, Ryuta Kawashima

NeuroImage　32　(2)　616-625　2006年5月

DOI： 10.1016/j.neuroimage.2006.03.040 　
Brain activation during the course of sentence comprehension 査読有り

Naho Ikuta, Motoaki Sugiura, Yuko Sassa, Jobu Watanabe, Yuko Akitsuki, Kazuki Iwata, Naoki Miura, Hideyuki Okamoto, Yoshihiko Watanabe, Shigeru Sato, Kaoru Horie, Yoshihiko Matsue, Ryuta Kawashima

Brain and Language　97　154-161　2006年5月1日

DOI： 10.1016/j.bandl.2005.10.006 　

ISSN：0093-934X
Cortical activation in the processing of passive sentences in L1 and L2: an fMRI study. 査読有り

Yokoyama S, Okamoto H, Miyamoto T, Yoshimoto K, Kim J, Iwata K, Jeong H, Uchida S, Ikuta N, Sassa Y, Nakamura W, Horie K, Sato S, Kawashima R

NeuroImage　30　570-579　2006年4月
出版者・発行元： 2
DOI： 10.1016/j.neuroimage.2005.09.066 　

ISSN：1053-8119
Artifact reduction for simultaneous EEG/fMRI recording: Adaptive FIR reduction of imaging artifacts 査読有り

Xiaohong Wan, Kazuki Iwata, Jorge Riera, Masaharu Kitamura, Ryuta Kawashima

Clinical Neurophysiology　117　(3)　681-692　2006年3月

DOI： 10.1016/j.clinph.2005.07.025 　

ISSN：1388-2457
Artifact reduction for EEG/fMRI recording: Nonlinear reduction of ballistocardiogram artifacts 査読有り

Xiaohong Wan, Kazuki Iwata, Jorge Riera, Torh Ozaki, Masaharu Kitamura, Ryuta Kawashima

Clinical Neurophysiology　117　(3)　668-680　2006年3月

DOI： 10.1016/j.clinph.2005.12.015 　

ISSN：1388-2457
Anatomical and functional mapping of the human brain: Japanese brain image database project 査読有り

Hiroshi Fukuda, Shigeo Kinomura, Yasuyuki Taki, Ryo Goto, Kentaro Inoue, Ken Okada, Shinya Uchida, Kazunori Sato, Ryuta Kawashima

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　635-+　2006年
Cortical mechanisms for risk perception 査読有り

Sugiura Motoaki, Sekiguchi Atsushi, Wakusawa Keisuke, Sassa Yuko, Jeong Hyeorong, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　55　S132　2006年

ISSN：0168-0102
Mechanisms for processing of intellectual excitement 査読有り

Fukushima Ai, Miura Naoki, Uchida Shinya, Sugiura Motoaki, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　55　S196　2006年

ISSN：0168-0102
Cortical mechanisms of memory transfer between learning and retrieval modes in foreign language word learning 査読有り

jeong Hyeon Jeong, Sugiura Motoaki, Sassa Yuko, Wakusawa Keisuke, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　55　S197　2006年

ISSN：0168-0102
Brain networks for communicative speech production: Feeling inference and speech content production 査読有り

Sassa Yuko, Sugiura Motoaki, Jeong Hyeonjeong, Wakusawa Keisuke, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

NEUROSCIENCE RESEARCH　55　S262　2006年

ISSN：0168-0102
The change of brain activation with increase of stimulus presentation rate during the paced visually serial addition test 査読有り

Shinya Uchida, Jobu Watanabe, Motoaki Sugiura, Naoki Miura, Kazuki Iwata, Shigeo Kinomura, Kazunori Sato, Kaoru Horie, Shigeru Sato, Hiroshi Fukuda, Ryuta Kawashima

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　837-+　2006年

DOI： 10.1142/9781860948800_0090 　
Automatic brain tissue segmentation method from MRI T1-weighted data 査読有り

Naoki Miura, Makoto Takahashi, Ryuta Kawashima, Masaharu Kitamura

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　1065-+　2006年

DOI： 10.1142/9781860948800_0114 　
Event-related and spontaneous EEG correlates of concurrent functional MRI 査読有り

Xiaohong Wan, Jorge Riera, Makoto Takahashi, Toshio Wakabayashi, Ryuta Kawashima

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　1105-+　2006年

DOI： 10.1142/9781860948800_0119 　
Male elderly subthreshold depression patients have smaller volume of medial part of prefrontal cortex and precentral gyrus compared with age-matched normal subjects: a voxel-based morphometry.0 査読有り

Taki Yasuyuki, Kinomura Shigeo, Awata Shuichi, Inoue Kentaro, Sato Kazunori, Ito Hiroshi, Goto Ryoi, Uchida Shinya, Tsuji Ichiro, Arai Hiroyuki, Kawashima Ryuta, Fukuda Hiroshi

J Affect Disord　88　(3)　313-320　2005年11月

DOI： 10.1016/j.jad.2005.08.003 　
"年齢相応の脳"とは?(第1報)

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 伊藤浩, 井上健太郎, 岡田賢, 小野修一, 川島隆太, 福田寛

臨床放射線　50　(8)　983-990　2005年8月
出版者・発行元：金原出版(株)
ISSN：0009-9252
日本語の名詞と助数詞の照合時に見られる脳活動 : 事象関連電位による研究(<特集>人間による言語理解・言語処理)

酒井由美, 岩田一樹, リエラホルヘ, 万小紅, 横山悟, 下田由輝, 川島隆太, 吉本啓, 小泉政利

電子情報通信学会技術研究報告. TL, 思考と言語　105　(170)　17-22　2005年7月2日
出版者・発行元：社団法人電子情報通信学会
ISSN：0913-5685

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日本語には、事物を数える際に数詞の後について用いられる接辞、「助数詞」が存在する(「〜匹」「〜本」など)。助数詞は、数える対象を表す名詞によって決まる。本研究では、日本語の助数詞がどのような処理過程を経て名詞と照合されるかを解明するために、事象関連電位による実験を行った。日本語母語話者10名を対象に、名詞と助数詞の組み合わせを視覚提示し、自然さを判断させたところ、不自然な組み合わせを読んだ場合に、被験者の脳波からN400成分が計測された。この結果は、名詞と助数詞の照合には意味処理が関わっており、ジェンダーの一致などの文法的処理を必要とする言語現象とは処理が異なるということを示すものである。
Cortical activation during reading of ancient versus modern Japanese texts: fMRI study 査読有り

Naoki Miura, Jobu Watanabe, Kazuki Iwata, Yuko Sassa, Jorge Riera, Hideo Tsuchiya, Shigeru Sato, Kaoru Horie, Makoto Takahashi, Masaharu Kitamura, Ryuta Kawashima

NeuroImage　26　426-431　2005年6月1日

DOI： 10.1016/j.neuroimage.2005.01.041 　

ISSN：1053-8119
機能的磁気共鳴画像法を用いた計器監視作業時の脳活動解析査読有り

三浦直樹, 渡邉丈夫, 高橋信, 川島隆太, 北村正晴

ヒューマンインタフェース学会論文誌　7　(2)　199-206　2005年5月25日
出版者・発行元：ヒュ-マンインタフェ-ス学会
ISSN：1344-7262
Development of integrated remote DB system for brain image management

Wong Tze Poh Kelvin, Diantono Catur, Makoto Takahashi, Ryuta Kawashima, Masaharu Kitamura

Proceedings of the SICE Annual Conference　2416-2419　2005年
Cortical mechanisms of visual self-recognition. 査読有り

Sugiura M, Watanabe J, Maeda Y, Matsue Y, Fukuda H, Kawashima R

NeuroImage　24　143-149　2005年1月1日
出版者・発行元： 1
DOI： 10.1016/j.neuroimage.2004.07.063 　

ISSN：1053-8119
Mental visual synthesis is originated in the fronto-temporal network of the left hemisphere 査読有り

Yukihito Yomogida, Motoaki Sugiura, Jobu Watanabe, Yuko Akitsuki, Yuko Sassa, Teruyuki Sato, Yoshihiko Matsue, Ryuta Kawashima

Cerebral Cortex　14　(12)　1376-1383　2004年12月

DOI： 10.1093/cercor/bhh098 　

ISSN：1047-3211
Development of a Tablet device-based Neuroimage Analysis Support System 査読有り

W.T.P. Kelvin, Makoto Takahashi, Ryuta Kawashima, Masaharu Kitamura

Proceedings of CSEPC2004 (Cognitive System Engineering in Process Control)　1　121-126　2004年11月
Different roles of the frontal and parietal regions in memory-guided saccade: a PCA approach on time course of BOLD signal changes. 査読有り

Sugiura M, Watanabe J, Maeda Y, Matsue Y, Fukuda H, Kawashima R

Human brain mapping　23　129-139　2004年11月
出版者・発行元： 3
DOI： 10.1002/hbm.20049 　

ISSN：1065-9471
作業記憶課題における刺激呈示速度変化に伴う脳活動量の検討(Brain activation with the changes of presentation rate of stimulus during a working memory task)

内田信也, 岩田一樹, 渡辺丈夫, 佐々祐子, 三浦直樹, 木之村重男, 佐藤和則, 福田寛, 川島隆太

神経化学　43　(2-3)　575-575　2004年8月
出版者・発行元： (一社)日本神経化学会
ISSN：0037-3796
Target dependency of brain mechanism involved in dispositional inference: a PET study 査読有り

M Sugiura, R Gotoh, K Okada, K Yamaguchi, M Itoh, H Fukuda, R Kawashima

NEUROIMAGE　21　(4)　1377-1386　2004年4月

DOI： 10.1016/j.neuroimage.2003.11.021 　

ISSN：1053-8119
Voxel-based morphometry of human brain with age and cerebrovascular risk factors. 査読有り

Taki Y, Goto R, Evans A, Zijdenbos A, Neelin P, Lerch J, Sato K, Ono S, Kinomura S, Nakagawa M, Sugiura M, Watanabe J, Kawashima R, Fukuda H

Neurobiology of aging　25　(4)　455-463　2004年4月

DOI： 10.1016/j.neurobiolaging.2003.09.002 　

ISSN：0197-4580
The human parietal cortex is involved in spatial processing of tongue movement - An fMRI study 査読有り

Jobu Watanabe, Motoaki Sugiura, Naoki Miura, Yoshihiko Watanabe, Yasuhiro Maeda, Yoshihiko Matsue, Ryuta Kawashima

NeuroImage　21　1289-1299　2004年4月1日

DOI： 10.1016/j.neuroimage.2003.10.024 　

ISSN：1053-8119
A state-space model of the hemodynamic approach: Nonlinear filtering of BOLD signals 査読有り

Jorge J. Riera, Jobu Watanabe, Iwata Kazuki, Miura Naoki, Eduardo Aubert, Tohru Ozaki, Ryuta Kawashima

NeuroImage　21　547-567　2004年1月1日

DOI： 10.1016/j.neuroimage.2003.09.052 　

ISSN：1053-8119
皮質下微小梗塞・虚血性病変と皮質灰白質容積変化の関連

木之村重男, 後藤了以, 井上健太郎, 中川学, 瀧靖之, 佐藤和則, 福田寛, 川島隆太

日本医学放射線学会雑誌　63　(9)　596-597　2003年11月
出版者・発行元： (公社)日本医学放射線学会
ISSN：0048-0428

eISSN：1347-7951
Can personality traits predict pathological responses to audiovisual stimulation? 査読有り

Yambe Tomoyuki, Yoshizawa Makoto, Fukudo Shin, Fukuda Hiroshi, Kawashima Ryuta, Shizuka Kazuhiko, Nanka Shunsuke, Tanaka Akira, Abe Ken-ichi, Shouji Tomonori, Hongo Michio, Tabayashi Kouichi, Nitta Shin-ichi

Biomed Pharmacother　57 Suppl 1　83s-86s　2003年10月

DOI： 10.1016/j.biopha.2003.08.010 　
映像コンテンツによる視聴覚刺激が生体の自律神経機能に与える影響査読有り

段旭東, 王慶田, 山家智之, 仁田新一, 川島隆太

Journal of International Society of Life Information Science　21　(2)　455-463　2003年9月
Cortical activation during reading aloud of long sentences: fMRI study 査読有り

Naoki Miura, Kazuki Iwata, Jobu Watanabe, Motoaki Sugiura, Yuko Akitsuki, Yuko Sassa, Naho Ikuta, Hideyuki Okamoto, Yoshihiko Watanabe, Jorge Riera, Yasuhiro Maeda, Yoshihiko Matsue, Ryuta Kawashima

NeuroReport　14　1563-1566　2003年8月26日

DOI： 10.1097/00001756-200308260-00004 　

ISSN：0959-4965
Thinking of the future and past: the roles of the frontal pole and the medial temporal lobes. 国際誌

Jiro Okuda, Toshikatsu Fujii, Hiroya Ohtake, Takashi Tsukiura, Kazuyo Tanji, Kyoko Suzuki, Ryuta Kawashima, Hiroshi Fukuda, Masatoshi Itoh, Atsushi Yamadori

NeuroImage　19　(4)　1369-80　2003年8月

ISSN：1053-8119

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Human lesion data have indicated that the frontal polar area might be critically involved in having an insight into one's future. Retrospective memory mediated by medial temporal lobes and related structures, on the other hand, could be used to extract one's future prospects efficiently. In the present study, we investigated the roles of these two brain structures in thinking of the future and past by using positron emission tomography (PET) and a naturalistic task setting. We measured regional cerebral blood flow (rCBF) in healthy subjects while they were talking about their future prospects or past experiences, with regard to two different temporal windows (in years or days). Many areas in the frontal and the medial temporal lobes were activated during the future and past tasks compared with a control task requiring semantic retrieval. Among these, areas in anteromedial frontal pole showed greater activation during the future tasks than during the past tasks, showing significant effect of temporal distance from the present. Most areas in the medial temporal lobes showed greater or equivalent level of activations during the future tasks compared with the past tasks. The present results suggest that thinking of the future is closely related to retrospective memory, but that specific areas in the frontal pole and the medial temporal lobes are more involved with thinking of the future than that of the past.
Context-dependent cortical activation in response to financial reward and penalty: an event-related fMRI study. 査読有り

Akitsuki Yuko, Sugiura Motoaki, Watanabe Jobu, Yamashita Keiichi, Sassa Yuko, Awata Shuichi, Matsuoka Hiroo, Maeda Yasuhiro, Matsue Yoshihiko, Fukuda Hiroshi, Kawashima Ryuta

Neuroimage　19　(4)　1674-1685　2003年8月
出版者・発行元：
DOI： 10.1016/S1053-8119(03)00250-7 　

ISSN：1053-8119
ヒトの脳における加齢,脳血管危険因子と灰白質,白質の形態変化との相関

瀧靖之, 川島隆太, 後藤了以, 佐藤和則, 小野修一, 木之村重男, 中川学, 杉浦元亮, 渡辺丈夫, 福田寛

加齢医学研究所雑誌　54　(1～2)　50-50　2003年3月
出版者・発行元：東北大学加齢医学研究所
ISSN：1340-3397
追跡眼球運動と注意－fMRI所見を中心に－

松江克彦, 前田泰弘, 渡部芳彦, 佐藤優子, 杉浦元亮, 月浦崇, 長谷川武弘, 上埜高志, 川島隆太

東北福祉大学感性福祉研究所年報　4　47-53　2003年3月
Neuroanatomical database of normal Japanese brains 査読有り

Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Ryuta Kawashima

Neural Networks　16　(9)　1301-1310　2003年
出版者・発行元： Elsevier Ltd
DOI： 10.1016/j.neunet.2003.06.004 　

ISSN：0893-6080
Time-dependent contribution of the hippocampal complex when remembering the past: a PET study. 査読有り

Tsukiura T, Fujii T, Okuda J, Ohtake H, Kawashima R, Itoh M, Fukuda H, Yamadori A

Neuroreport　13　2319-2323　2002年12月
出版者・発行元： 17
DOI： 10.1097/01.wnr.0000044989.13025.79 　

ISSN：0959-4965
Automatic brain tissue extraction method using erosion-dilation treatment (BREED) from three-dimensional magnetic resonance imaging T1-weighted data 査読有り

Naoki Miura, Akito Taneda, Kazuhito Shida, Ryuta Kawashima, Yoshiyuki Kawazoe, Hiroshi Fukuda, Toshio Shimizu

Journal of Computer Assisted Tomography　26　927-932　2002年11月1日

DOI： 10.1097/00004728-200211000-00012 　

ISSN：0363-8715
脳血流SPECTカウントは脳灰白質密度を反映するか?

木之村重男, 後藤了以, 井上健太郎, 中川学, 瀧靖之, 佐藤和則, 川島隆太, 福田寛

核医学　39　(3)　377-377　2002年9月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
Brain activation during the fist-edge-palm test: a functional MRI study. 査読有り

Umetsu A, Okuda J, Fujii T, Tsukiura T, Nagasaka T, Yanagawa I, Sugiura M, Inoue K, Kawashima R, Suzuki K, Tabuchi M, Murata T, Mugikura S, Higano S, Takahashi S, Fukuda H, Yamadori A

NeuroImage　17　(1)　385-392　2002年9月
出版者・発行元： 1
DOI： 10.1006/nimg.2002.1218 　

ISSN：1053-8119
Neural basis of the retrieval of people's names: evidence from brain-damaged patients and fMRI. 査読有り

Tsukiura T, Fujii T, Fukatsu R, Otsuki T, Okuda J, Umetsu A, Suzuki K, Tabuchi M, Yanagawa I, Nagasaka T, Kawashima R, Fukuda H, Takahashi S, Yamadori A

Journal of cognitive neuroscience　14　922-937　2002年8月
出版者・発行元： 6
DOI： 10.1162/089892902760191144 　

ISSN：0898-929X
言語処理とその脳の活動領域の考察

佐々祐子, 杉浦元亮, 渡辺丈夫, 秋月祐子, 佐藤滋, 川島隆太

情報処理学会研究報告. 自然言語処理研究会報告　2002　(66)　91-97　2002年7月15日
出版者・発行元：社団法人情報処理学会
ISSN：0919-6072

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本研究は、functionarl Magnetic Resonance Imaging(fMRI)を用いて、聴覚言語理解時の統語関係の理解と意味理解に関わる脳の領域を探ることが目的である。被験者には、正しい文、文法の誤った文、意味が不自然な文をランダムに聞かせそれぞれの文の正誤判断をさせた。その結果左半球の中前頭回、下前頭回、下頭頂小葉に共通に有意な脳の賦活化が観察された。また、文法の誤った文を聞いた時は、下頭頂小葉が最も有意に、一方、意味の不自然な文を聞いた時は、下前頭回が最も有意に脳の賦活化した。以上のことから、文の「誤り」「不自然さ」に関わる領域について、文法情報処理と意味情報処理はそれぞれ異なる領域で行われているというよりはむしろ、前頭連合野から頭頂連合野のネットワークを用い、相補的に処理が行われている可能性が示唆された。
言語処理とその脳の活動領域の考察

佐々祐子, 杉浦元亮, 渡辺丈夫, 秋月祐子, 佐藤滋, 川島隆太

電子情報通信学会技術研究報告. NLC, 言語理解とコミュニケーション　102　(199)　91-97　2002年7月8日
出版者・発行元：社団法人電子情報通信学会
ISSN：0913-5685

詳細を見る詳細を閉じる

本研究は、functionarl Magnetic Resonance Imaging(fMRI)を用いて、聴覚言語理解時の統語関係の理解と意味理解に関わる脳の領域を探ることが目的である。被験者には、正しい文、文法の誤った文、意味が不自然な文をランダムに聞かせそれぞれの文の正誤判断をさせた。その結果左半球の中前頭回、下前頭回、下頭頂小葉に共通に有意な脳の賦活化が観察された。また、文法の誤った文を聞いた時は、下頭頂小葉が最も有意に、一方、意味の不自然な文を聞いた時は、下前頭回が最も有意に脳の賦活化した。以上のことから、文の「誤り」「不自然さ」に関わる領域について、文法情報処理と意味情報処理はそれぞれ異なる領域で行われているというよりはむしろ、前頭連合野から頭頂連合野のネットワークを用い、相補的に処理が行われている可能性が示唆された。
Direction of cross-modal information transfer affects human brain activation: a PET study 査読有り

R Kawashima, J Watanabe, T Kato, A Nakamura, K Hatano, T Schormann, K Sato, H Fukuda, K Ito, K Zilles

EUROPEAN JOURNAL OF NEUROSCIENCE　16　(1)　137-144　2002年7月

DOI： 10.1046/j.1460-9568.2002.02053.x 　

ISSN：0953-816X
The role of the basal forebrain in episodic memory retrieval: a positron emission tomography study. 査読有り

Fujii T, Okuda J, Tsukiura T, Ohtake H, Miura R, Fukatsu R, Suzuki K, Kawashima R, Itoh M, Fukuda H, Yamadori A

NeuroImage　15　501-508　2002年3月
出版者・発行元： 3
DOI： 10.1006/nimg.2001.0995 　

ISSN：1053-8119
脳萎縮に関わる危険因子 MR画像による解析

瀧靖之, 川島隆太, 小野修一, 木之村重男, 後藤了以, 佐藤和則, 福田寛

加齢医学研究所雑誌　53　(1～2)　15-15　2002年2月
出版者・発行元：東北大学加齢医学研究所
ISSN：1340-3397
The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study 査読有り

Jobu Watanabe, Motoaki Sugiura, Kazunori Sato, Yuko Sato, Yasuhiro Maeda, Yoshihiko Matsue, Hiroshi Fukuda, Ryuta Kawashima

NeuroImage　17　(3)　1207-1216　2002年
出版者・発行元： Academic Press Inc.
DOI： 10.1006/nimg.2002.1198 　

ISSN：1053-8119
Hypoperfusion in the supplementary motor area, dorsolateral prefrontal cortex and insular cortex in Parkinson's disease

A Kikuchi, A Takeda, T Kimpara, M Nakagawa, R Kawashima, M Sugiura, S Kinomura, H Fukuda, K Chida, N Okita, S Takase, Y Itoyama

JOURNAL OF THE NEUROLOGICAL SCIENCES　193　(1)　29-36　2001年12月

DOI： 10.1016/S0022-510X(01)00641-4 　

ISSN：0022-510X
Different distribution of the activated areas in the dorsal premotor cortex during visual and auditory reaction-time tasks. 査読有り

Sugiura M, Kawashima R, Takahashi T, Xiao R, Tsukiura T, Sato K, Kawano K, Iijima T, Fukuda H

NeuroImage　14　(5)　1168-1174　2001年11月
出版者・発行元： 5
DOI： 10.1006/nimg.2001.0898 　

ISSN：1053-8119
個人的知合いと有名人の名前の認知に関与する脳領域:event related fMRI

杉浦元亮, 渡辺丈夫, 佐藤輝幸, 佐藤優子, 前田泰弘, 松江克彦, 原田淳, 佐藤和則, 福田寛, 川島隆太

神経化学　40　(2-3)　403-403　2001年9月
出版者・発行元： (一社)日本神経化学会
ISSN：0037-3796
視聴覚刺激によって生体は安らぐことが出来るか?

山家智之, 川島隆太, 杉浦元亮, 南家俊介, 福田寛, 吉澤誠, 仁田新一

生体・生理工学シンポジウム論文集　16　443-446　2001年8月29日
飲酒前後におけるヒトの皮質連合野活動の比較 : 機能的MRIによる検討

泰羅雅登, 川島隆太, 杉浦元亮, 渡辺丈夫, 井上健太郎, 鐘ヶ江孝, 塚本昭次郎

日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence　36　(4)　314-315　2001年8月28日

ISSN：1341-8963
Activation reduction in anterior temporal cortices during repeated recognition of faces of personal acquaintances 査読有り

M Sugiura, R Kawashima, K Nakamura, N Sato, A Nakamura, T Kato, K Hatano, T Schormann, K Zilles, K Sato, K Ito, H Fukuda

NEUROIMAGE　13　(5)　877-890　2001年5月

DOI： 10.1006/nimg.2001.0747 　

ISSN：1053-8119
既知の人物の名前の視覚認知に関与する脳領域:fMRI研究 (1 生命科学部門)

杉浦元亮, 川島隆太, 渡辺丈夫

感性福祉研究所年報　(2)　113-118　2001年5月
出版者・発行元：東北福祉大学感性福祉研究所
ISSN：1344-9966
Different neural systems for recognizing plants, animals, and artifacts 査読有り

R Kawashima, G Hatano, K Oizumi, M Sugiura, H Fukuda, K Itoh, T Kato, A Nakamura, K Hatano, S Kojima

BRAIN RESEARCH BULLETIN　54　(3)　313-317　2001年2月

ISSN：0361-9230
人の性格と脳活動の関係

杉浦元亮, 川島隆太, 中川学, 岡田賢, 佐藤多智雄, 後藤了以, 佐藤和則, 小野修一, 福田寛

加齢医学研究所雑誌　52　(1～2)　31-31　2001年1月
出版者・発行元：東北大学加齢医学研究所
ISSN：1340-3397
Neural substrates for recognition of familiar voices: a PET study 査読有り

K Nakamura, R Kawashima, M Sugiura, T Kato, A Nakamura, K Hatano, S Nagumo, K Kubota, H Fukuda, K Ito, S Kojima

NEUROPSYCHOLOGIA　39　(10)　1047-1054　2001年

DOI： 10.1016/S0028-3932(01)00037-9 　

ISSN：0028-3932
Activation in the ipsilateral posterior parietal cortex during tool use: A PET study 査読有り

Kentaro Inoue, Ryuta Kawashima, Motoaki Sugiura, Akira Ogawa, Torsten Schormann, Karl Zilles, Hiroshi Fukuda

NeuroImage　14　(6)　1469-1475　2001年
出版者・発行元： Academic Press Inc.
DOI： 10.1006/nimg.2001.0942 　

ISSN：1053-8119
動作イメージ課題における functional MRI 計測 : 手の把持動作イメージによる実験

上條憲一, 山崎敏正, 川島隆太, 杉浦元亮, 渡辺丈夫, 福田寛, 佐藤優子, 前田泰弘, 松江克彦

生体・生理工学シンポジウム論文集　15　349-352　2000年10月13日
Functional delineation of the human occipito-temporal areas related to face and scene processing - A PET study 査読有り

K Nakamura, R Kawashima, N Sato, A Nakamura, M Sugiura, T Kato, K Hatano, K Ito, H Fukuda, T Schormann, K Zilles

BRAIN　123　1903-1912　2000年9月

DOI： 10.1093/brain/123.9.1903 　

ISSN：0006-8950
Retention of words in long-term memory: a functional neuroanatomical study with PET 査読有り

J Okuda, T Fujii, A Yamadori, R Kawashima, T Tsukiura, H Ohtake, R Fukatsu, K Suzuki, M Itoh, H Fukuda

NEUROREPORT　11　(2)　323-328　2000年2月

DOI： 10.1097/00001756-200002070-00020 　

ISSN：0959-4965
Four dimensions in the state of memory and emotion concerned with a person: Factor analysis using subject's self evaluation and PET

M. Sugiura, Ryuta Kawashima, R. Gotoh, K. Okada, J. Watanabe, K. Satoh, K. Yamaguchi, M. Itoh, T. Schormann, H. Fukuda

NeuroImage　11　(5 PART II)　2000年

DOI： 10.1016/s1053-8119(00)91171-6 　

ISSN：1053-8119
Recognition of the familiar personal names: Event-related fMRI

M. Sugiura, Ryuta Kawashima, J. Watanabe, R. Gotoh, K. Satoh, Y. Satoh, Y. Maeda, K. Matsue, H. Fukuda

NeuroImage　11　(5 PART II)　2000年

DOI： 10.1016/s1053-8119(00)91319-3 　

ISSN：1053-8119
Recognition of faces - a combined study using PET and MEG 査読有り

A Nakamura, N Sato, M Sugiura, K Nakamura, R Kawashima, T Kato, K Horibe, T Yamada, Y Abe, T Kachi, K Ito

POSITRON EMISSION TOMOGRAPHY IN THE MILLENNIUM　1197　79-83　2000年

ISSN：0531-5131
A PET study of visuomotor learning under optical rotation 査読有り

Kentaro Inoue, Ryuta Kawashima, Kazunori Satoh, Shigeo Kinomura, Motoaki Sugiura, Ryoi Goto, Masatoshi Ito, Hiroshi Fukuda

NeuroImage　11　(5 I)　505-516　2000年
出版者・発行元： Academic Press Inc.
DOI： 10.1006/nimg.2000.0554 　

ISSN：1053-8119
Correlation between human personality and neural activity in cerebral cortex 査読有り

Motoaki Sugiura, Ryuta Kawashima, Manabu Nakagawa, Ken Okada, Tachio Sato, Ryoi Goto, Kazunori Sato, Shuichi Ono, Thorsten Schormann, Karl Zilles, Hiroshi Fukuda

NeuroImage　11　(5 I)　541-546　2000年
出版者・発行元： Academic Press Inc.
DOI： 10.1006/nimg.2000.0564 　

ISSN：1053-8119
Different time course between scene processing and face processing: a MEG study 査読有り

N Sato, K Nakamura, A Nakamura, N Sugiura, K Ito, H Fukuda, R Kawashima

NEUROREPORT　10　(17)　3633-3637　1999年11月

DOI： 10.1097/00001756-199911260-00031 　

ISSN：0959-4965
Activation of the right inferior frontal cortex during assessment of facial emotion 査読有り

K Nakamura, R Kawashima, K Ito, M Sugiura, T Kato, A Nakamura, K Hatano, S Nagumo, K Kubota, H Fukuda, S Kojima

JOURNAL OF NEUROPHYSIOLOGY　82　(3)　1610-1614　1999年9月

ISSN：0022-3077
ニューラルネットワークを用いた脳血流SPECTの自動診断法の開発(第1報)

川島隆太, 粂川一也, 佐藤和則, 後藤了以, 中川学, 杉浦元亮, 小野修一, 佐藤多智雄, 福田寛

核医学　36　(6)　623-623　1999年8月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
The human amygdala plays an important role in gaze monitoring - A PET study 査読有り

R Kawashima, M Sugiura, T Kato, A Nakamura, K Hatano, K Ito, H Fukuda, S Kojima, K Nakamura

BRAIN　122　(4)　779-783　1999年4月

DOI： 10.1093/brain/122.4.779 　

ISSN：0006-8950
Anatomic validation of spatial normalization methods for PET 査読有り

Motoaki Sugiura, Ryuta Kawashima, Norihiro Sadato, Michio Senda, Iwao Kanno, Keiichi Oda, Kazunori Sato, Yoshiharu Yonekura, Hiroshi Fukuda

Journal of Nuclear Medicine　40　(2)　317-322　1999年2月

ISSN：0161-5505
Parametric mapping of cerebral blood flow deficits in Alzheimer's disease: A SPECT study using HMPAO and Image Standardization Technique 査読有り

Muhammad Babar Imran, Ryuta Kawashima, Shuichi Awata, Kazunori Sato, Shigeo Kinomura, Shuichi Ono, Seiro Yoshioka, Mitsumoto Sato, Hiroshi Fukuda

Journal of Nuclear Medicine　40　(2)　244-249　1999年2月

ISSN：0161-5505
Attention towards direction and speed of optical flow activate bilateral parieto-occipital and intraparietal cortex - A PET study

Ken Okada, Ryuta Kawashima, Hiroshi Fukuda

NeuroImage　9　(6)　S778　1999年

ISSN：1053-8119
Somatotopy in the human cerebellum

Motoaki Sugiura, Takehiko Bando, Kenogo Ito, Kentaro Hatano, Karl Zilles, Thorsten Schormann, Hiroshi Fukuda, Motoaki Augiura, Ryuta Kawashima, Takashi Kato

NeuroImage　9　(6)　S515　1999年

ISSN：1053-8119
Functional PET mapping of human brain in olfactory processing

Ahmad Qureshy, Ryuta Kawashima, M. B. Imran, Motoaki Sugiura, Ryoi Goto, Ken Okada, Kentarou Inoue, Masatoshi Itoh, Thorsten Schormann, Karl Zilles, Hiroshi Fukuda

NeuroImage　9　(6)　S807　1999年

ISSN：1053-8119
Activation of the bilateral parietal cortex during grasping with the tool: A PET study

Kentaro Inoue, Ryuta Kawashima, Motoaki Sugiura, Akira Ogawa, Thorsten Schormann, Karl Zilles, Hiroshi Fukuda

NeuroImage　9　(6)　S501　1999年

ISSN：1053-8119
Regional cerebral blood flow decrease in the Parkinson's disease patients compared with age and brain atrophy matched normal subjects

Manabu Nakagawa, Akio Kikuchi, Ryuta Kawashima, Atushi Takeda, Shigeo Kinomura, Ryoi Goto, Syuuichi Ono, Tachio Sato, Yasuto Itoyama, Hiroshi Fukuda

NeuroImage　9　(6)　S579　1999年

ISSN：1053-8119
Inter-subject and inter-trial variability of brain activation in PET study of face discrimination tasks

Sugiura, M., Kawashima, R., Nakamura, K., Sato, N., Kato, T., Pakamura, A., Hatano, K., Schormann, T., Itoh, K., Nakamura, A., Zilles, K., Fukuda, H.

NeuroImage　9　(6 PART II)　1999年

ISSN：1053-8119
Cerebellar activation in relation to vergence eye movement - Comparison to pursuit and saccadic eye movement

Takagi, M., Hayakawa, Y., Sugiura, M., Kato, R., Hatano, H., Nakamura, A., Takada, R., Hasebe, H., Oyamada, H., Kawashima, R., Ito, K., Ukai, K., Fukuda, H., Bando, T., Zilles, K., Schormann, T.

NeuroImage　9　(6 PART II)　1999年

ISSN：1053-8119
Categorization of sound, onomatopoeia and name of objects: A PET study

Nakamura, A., Kawashima, R., Ito, K., Sugiura, M., Kato, T., Hatano, K., Nagumo, S., Asakawa, K., Fukuda, H., Kiritani, S., Zilles, K., Schormann, T.

NeuroImage　9　(6 PART II)　1999年

ISSN：1053-8119
Human cortical areas activated in relation to vergence eye movements - A PET study 査読有り

H. Hasebe, H. Oyamada, S. Kinomura, R. Kawashima, Y. Ouchi, S. Nobezawa, H. Tsukada, E. Yoshikawa, K. Ukai, R. Takada, M. Takagi, H. Abe, H. Fukuda, T. Bando

NeuroImage　10　(2)　200-208　1999年
出版者・発行元： Academic Press Inc.
DOI： 10.1006/nimg.1999.0453 　

ISSN：1053-8119
Selective visual and auditory attention toward utterances - A PET study 査読有り

Ryuta Kawashima, Satoshi Imaizumi, Koichi Mori, Ken Okada, Ryoi Goto, Shigeru Kiritani, Akira Ogawa, Hiroshi Fukuda

NeuroImage　10　(2)　209-215　1999年
出版者・発行元： Academic Press Inc.
DOI： 10.1006/nimg.1999.0452 　

ISSN：1053-8119
「Elast」による脳画像の形態的標準化

杉浦元亮, 川島隆太, 佐藤和則, 福田寛

核医学　35　(9)　957-957　1998年11月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
Participation of the prefrontal cortices in prospective memory: evidence from a PET study in humans 査読有り

OKuda J, Fujii T, Yamadori A, Kawashima R, Tsukiura T, Fukatsu R, Suzuki K, Ito M, Fukuda H

Neuroscience Letters　253　127-130　1998年9月

DOI： 10.1016/S0304-3940(98)00628-4 　

ISSN：0304-3940
The role of the left inferior temporal cortex for visual pattern discrimination - A PET study 査読有り

Ryuta Kawashima, Kazunori Satoh, Ryoi Goto, Kentaro Inoue, Masatoshi Itoh, Hiroshi Fukuda

NeuroReport　9　(7)　1581-1586　1998年5月11日
出版者・発行元： Lippincott Williams and Wilkins
DOI： 10.1097/00001756-199805110-00060 　

ISSN：0959-4965
Neuroanatomical correlates of the assessment of facial attractiveness 査読有り

K Nakamura, R Kawashima, S Nagumo, K Ito, M Sugiura, T Kato, A Nakamura, K Hatano, K Kubota, H Fukuda, S Kojima

NEUROREPORT　9　(4)　753-757　1998年3月

DOI： 10.1097/00001756-199803090-00035 　

ISSN：0959-4965
A PET study of axis orientation discrimination 査読有り

Masato Taira, Ryuta Kawashima, Kentaro Inoue, Hiroshi Fukuda

NeuroReport　9　(2)　283-288　1998年1月26日
出版者・発行元： Lippincott Williams and Wilkins
DOI： 10.1097/00001756-199801260-00020 　

ISSN：0959-4965
Shifting attention to left or right hemi-visualfield activates left parietal cortex.: A PET study

Shigeo Kinomura, Ryuta Kawashima, Kenntaro Inoue, Motoaki Sugiura, Kenn Okada, Hiroshi Fukuda, Masatoshi Itoh, Takehiko Fujiwara

NeuroImage　7　(4)　S72　1998年
出版者・発行元： Academic Press Inc.
DOI： 10.1016/s1053-8119(18)30905-4 　

ISSN：1053-8119
Cortical activation during visuomotor learning with optical rotation

Kentaro Inoue, Ryuta Kawashima, Kazunori Satoh, Shigeo Kinomura, Ryoi Goto, Motoaki Sugiura, Masatoshi Ito, Hiroshi Fukuda

NeuroImage　7　(4 PART II)　1998年

DOI： 10.1016/s1053-8119(18)31717-8 　

ISSN：1053-8119
Mean regional cerebral blood flow images of normal subjects using Technetium-99m-HMPAO by automated image registration

Muhammad Babar Imran, Ryuta Kawashima, Kazunori Sato, Shigeo Kinomura, Hiroshi Ito, Masamichi Koyama, Ryoi Goto, Shuichi Ono, Seiro Yoshioka, Hiroshi Fukuda

Journal of Nuclear Medicine　39　(1)　203-207　1998年1月

ISSN：0161-5505
Oculomotor sequence learning: A PET study

R. Kawashima, K. Okada, M. Sugiura, K. Sato, S. Kinomura, K. Inoue, H. Fukuda

NeuroImage　7　(4 PART II)　1998年

DOI： 10.1016/s1053-8119(18)31719-1 　

ISSN：1053-8119
Recognition of familiar people from their voices: A PET study

Nakamura, K., Kawashima, R., Ito, K., Sugiura, M., Kato, T., Nakamura, A., Hatano, K., Nagumo, S., Kubota, K., Fukuda, H., Kojima, S.

NeuroImage　7　(4 PART II)　1998年

DOI： 10.1016/s1053-8119(18)31665-3 　

ISSN：1053-8119
The inner representation of the self: PET activation study

Sugiura, M., Kawashima, R., Nakamura, K., Okada, K., Kato, T., Nakamura, A., Hatano, K., Itoh, K., Kojima, S., Fukuda, H.

NeuroImage　7　(4 PART II)　1998年

DOI： 10.1016/s1053-8119(18)31181-9 　

ISSN：1053-8119
Influence of ANOVA design and anatomical standardization on statistical mapping for PET activation 査読有り

Michio Senda, Kenji Ishii, Keiichi Oda, Norihiro Sadato, Ryuta Kawashima, Motoaki Sugiura, Iwao Kanno, Babak Ardekani, Satoshi Minoshima, Itaru Tatsumi

NeuroImage　8　(3)　283-301　1998年
出版者・発行元： Academic Press Inc.
DOI： 10.1006/nimg.1998.0370 　

ISSN：1053-8119
Use of automated image registration to generate mean brain SPECT image of Alzheimer's patients 査読有り

Muhammad Babar Imran, Ryuta Kawashima, Shuichi Awata, Kazunori Sato, Shigeo Kinomura, Hiroshi Ito, Shuichi Ono, Seiro Yoshioka, Mitsumoto Sato, Hiroshi Fukuda

Annals of Nuclear Medicine　12　(3)　127-132　1998年
出版者・発行元： Springer Tokyo
DOI： 10.1007/BF03164776 　

ISSN：0914-7187
PET study of pointing with visual feedback of moving hands 査読有り

Kentaro Inoue, Ryuta Kawashima, Kazunori Satoh, Shigeo Kinomura, Ryoi Goto, Masamichi Koyama, Motoaki Sugiura, Masatoshi Ito, Hiroshi Fukuda

Journal of Neurophysiology　79　(1)　117-125　1998年
出版者・発行元： American Physiological Society
DOI： 10.1152/jn.1998.79.1.117 　

ISSN：0022-3077
Oculomotor sequence learning: A positron emission tomography study 査読有り

Ryuta Kawashima, Jun Tanji, Ken Okada, Motoaki Sugiura, Kazunori Sato, Shigeo Kinomura, Kentaro Inoue, Akira Ogawa, Hiroshi Fukuda

Experimental Brain Research　122　(1)　1-8　1998年

DOI： 10.1007/s002210050485 　

ISSN：0014-4819
Activity in the parietal area during visuomotor learning with optical rotation 査読有り

Kentaro Inoue, Ryuta Kawashima, Kazunori Satoh, Shigeo Kinomura, Ryoi Goto, Motoaki Sugiura, Masatoshi Ito, Hiroshi Fukuda

NeuroReport　8　(18)　3979-3983　1997年12月22日
出版者・発行元： Lippincott Williams and Wilkins
DOI： 10.1097/00001756-199712220-00026 　

ISSN：0959-4965
Vocal identification of speaker and emotion activates different brain regions 査読有り

S Imaizumi, K Mori, S Kiritani, R Kawashima, M Sugiura, H Fukuda, K Itoh, T Kato, A Nakamura, K Hatano, S Kojima, K Nakamura

NEUROREPORT　8　(12)　2809-2812　1997年8月

DOI： 10.1097/00001756-199708180-00031 　

ISSN：0959-4965
Different roles of the left and right parahippocampal regions in verbal recognition: A PET study 査読有り

T Fujii, J Okuda, R Kawashima, A Yamadori, R Fukatsu, K Suzuki, M Ito, R Goto, H Fukuda

NEUROREPORT　8　(5)　1113-1117　1997年3月

ISSN：0959-4965
Functional asymmetry of cortical motor control in left-handed subjects 査読有り

Ryuta Kawashima, Kentaro Inoue, Kazunori Sato, Hiroshi Fukuda

NeuroReport　8　(7)　1729-1732　1997年
出版者・発行元： Lippincott Williams and Wilkins
DOI： 10.1097/00001756-199705060-00032 　

ISSN：0959-4965
11C-Benztropineによるムスカリン作動性アセチルコリン受容体の脳内分布の解析解剖学的標準化を用いて査読有り

小野修一, 川島隆太, 伊藤浩, 他

核医学　33　(7)　721-727　1996年7月
Regional cerebral blood flow changes of cortical motor areas and prefrontal areas in humans related to ipsilateral and contralateral hand movement

Ryuta Kawashima, Kenji Yamada, Shigeo Kinomura, Tatsuo Yamaguchi, Hiroshige Matsui, Seiro Yoshioka, Hiroshi Fukuda

Brain Research　623　(1)　33-40　1993年9月24日

DOI： 10.1016/0006-8993(93)90006-9 　

ISSN：0006-8993

︎全件表示 ︎最初の5件までを表示

MISC 381

意味を介在した手の3すくみの関係性の理解と実行に関わる神経基盤

塙杉子, 塙杉子, 塙杉子, ティローバンジャマン, 野澤孝之, 野澤孝之, 鄭嫣てい, 鄭嫣てい, 川島隆太

日本作業療法学会抄録集(CD-ROM)　57th　2023年

ISSN： 1880-6635
Power of words: Categorization of positive phrases and their effectiveness associated with personality, well-being and distress.

Ryo Ishibashi, Aki Eisenman-Shoda, Motoaki Sugiura, Takayuki Nozawa, Ryuta Kawashima

The 20th Conference of the Japanese Society for Cognitive Psychology　2022年10月

DOI： 10.14875/cogpsy.2022.0_67 　
聴性誘発脳磁界 (N1m) -音楽による影響と選択的注意-

白倉真之, 川瀬哲明, 川瀬哲明, 菅野彰剛, 菅野彰剛, 太田淳, 中里信和, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学(Web)　50　(4)　2022年

ISSN： 2188-031X
Lutein Has a Positive Impact on Brain Health in Healthy Older Adults: A Systematic Review of Randomized Controlled Trials and Cohort Studies

Ayano Yagi, Rui Nouchi, Laurie Butler, Ryuta Kawashima

NUTRIENTS　13　(6)　2021年6月

DOI： 10.3390/nu13061746 　

eISSN： 2072-6643
Reveal both behavioral and brain morphological differences between aged and adult wild-type mice (Proceedings of the 80th Annual Meeting of the Japanese Society for Animal Psychology)

Rie Ryoke, Hiroi Nonaka, Masatoshi Hirobe, Ryuta Kawashima

Japanese Journal of Animal Psychology　71　(1)　99-99　2021年
出版者・発行元： Japanese Society of Animal Psychology
DOI： 10.2502/janip.71.1.8 　

ISSN： 0916-8419

eISSN： 1880-9022
聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

白倉真之, 川瀬哲明, 川瀬哲明, 菅野彰剛, 菅野彰剛, 太田淳, 中里信和, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学(Web)　49　(5)　2021年

ISSN： 2188-031X
睡眠習慣の相違によるうつ状態と慢性疲労との弁別

中川誠秀, 中川誠秀, 竹内光, 瀧靖之, 野内類, 関口敦, 宮内誠カルロス, 飯塚邦夫, 横山諒一, 塙杉子, 榊浩平, ジョンビヨンジョン, ジョンビヨンジョン, 川島隆太

日本うつ病学会総会プログラム・抄録集　17th　2021年
コネクトーム解析による認知機能の予測

小川剛史, 竹内光, 池田純起, 瀧靖之, 野内類, 横山諒一, 事崎由佳, 中川誠秀, 関口敦, 飯塚邦夫, 塙杉子, 荒木剛, 宮内カルロス誠, 榊浩平, 佐々祐子, 野澤孝之, 横田晋, MAGISTROP Daniele, 川島隆太

電子情報通信学会大会講演論文集(CD-ROM)　2021　2021年

ISSN： 1349-144X
DHA摂取による認知症および認知機能低下リスクの低減効果:日本人も含めた前向きコホート研究の系統的レビュー及びメタ分析

福島洋一, 宮下博樹, 田所智, 渡部大志, 大塚礼, 野澤孝之, 川島隆太

日本栄養・食糧学会大会講演要旨集　74th　2020年
Implications of large-sample neuroimaging studies of creativity measured by divergent thinking

Hikaru Takeuchi, Ryuta Kawashima

Current Opinion in Behavioral Sciences　27　139-145　2019年6月1日
出版者・発行元： Elsevier Ltd
DOI： 10.1016/j.cobeha.2018.12.009 　

ISSN： 2352-1546
Experience to take another’s perspective enhance the right parieto-frontal activation 査読有り

Miura N, Sugiura M, Nozawa T, Yamamoto Y, Sasaki Y, Hamamoto Y, Yamazaki S, Hirano K, Takahashi M, Kawashima R

2019 OHBM Annual Meeting　2019年6月
東北大学病院の「てんかん脳磁図・ベスト・オブ・ザ・ベスト」

神一敬, 柿坂庸介, 石田誠, 菅野彰剛, 岩崎真樹, 川島隆太, 中里信和

日本生体磁気学会誌　32　(1)　62-63　2019年6月
側頭葉てんかん患者の体性感覚誘発磁界の信号強度は覚醒時のみ抑制される

石田誠, 神一敬, 柿坂庸介, 菅野彰剛, 川島隆太, 中里信和

日本生体磁気学会誌　32　(1)　150-151　2019年6月
現実社会的知識の理解における言語表現と社会文化的慣例の神経統合:日本の敬語の場合

CUI Haining, JEONG Hyeonjeong, OKAMOTO Kiyo, TAKAHASHI Daiko, KAWASHIMA Ryuta, SUGIURA Motoaki

日本神経化学会大会抄録集(Web)　62nd　2019年
MRIを用いた緑内障患者の眼球形態の検討

國時景子, 國時景子, 舘脇康子, 面高宗子, 松平泉, THYREAU Benjamin, 武藤達士, 川島隆太, 中澤徹, 瀧靖之, 瀧靖之

日本疫学会学術総会講演集(Web)　29th　2019年
オリゴデンドロサイト関連遺伝子多型(rs1059004)と自己スキーマ及び抑うつ症状との相関研究

小松浩, 小松浩, 竹内光, 菊地淑恵, 小野千晶, 兪志前, 兪志前, 飯塚邦夫, 角藤芳久, 舩越俊一, 舩越俊一, 大野高志, 川島隆太, 川島隆太, 川島隆太, 瀧靖之, 瀧靖之, 瀧靖之, 富田博秋, 富田博秋, 富田博秋, 富田博秋

日本うつ病学会総会プログラム・抄録集　16th　2019年
音程調整を伴う発声における早期の脳活動について―脳磁図を用いた検討―

野村有理, 川瀬哲明, 川瀬哲明, 菅野彰剛, 中里信和, 中里信和, 川島隆太, 香取幸夫

日本ヒト脳機能マッピング学会プログラム・抄録集　21st　93　2019年
A refined model of chronic cerebral hypoperfusion resulting in cognitive impairment and a low mortality rate in rats. 国際誌

Ahmed Mansour, Kuniyasu Niizuma, Sherif Rashad, Akira Sumiyoshi, Rie Ryoke, Hidenori Endo, Toshiki Endo, Kenichi Sato, Ryuta Kawashima, Teiji Tominaga

Journal of neurosurgery　131　(3)　892-902　2018年9月7日

DOI： 10.3171/2018.3.JNS172274 　

詳細を見る詳細を閉じる

OBJECTIVE: The cognitive deficits of vascular dementia and the vasoocclusive state of moyamoya disease have often been mimicked with bilateral stenosis/occlusion of the common carotid artery (CCA) or internal carotid artery. However, the cerebral blood flow (CBF) declines abruptly in these models after ligation of the CCA, which differs from "chronic" cerebral hypoperfusion. While some modified but time-consuming techniques have used staged occlusion of both CCAs, others used microcoils for CCA stenosis, producing an adverse effect on the arterial endothelium. Thus, the authors developed a new chronic cerebral hypoperfusion (CCH) model with cognitive impairment and a low mortality rate in rats. METHODS: Male Sprague-Dawley rats were subjected to unilateral CCA occlusion and contralateral induction of CCA stenosis (modified CCA occlusion [mCCAO]) or a sham operation. Cortical regional CBF (rCBF) was measured using laser speckle flowmetry. Cognitive function was assessed using a Barnes circular maze (BCM). MRI studies were performed 4 weeks after the operation to evaluate cervical and intracranial arteries and parenchymal injury. Behavioral and histological studies were performed at 4 and 8 weeks after surgery. RESULTS: The mCCAO group revealed a gradual CBF reduction with a low mortality rate (2.3%). White matter degeneration was evident in the corpus callosum and corpus striatum. Although the cellular density declined in the hippocampus, MRI revealed no cerebral infarctions after mCCAO. Immunohistochemistry revealed upregulated inflammatory cells and angiogenesis in the hippocampus and cerebral cortex. Results of the BCM assessment indicated significant impairment in spatial learning and memory in the mCCAO group. Although some resolution of white matter injury was observed at 8 weeks, the animals still had cognitive impairment. CONCLUSIONS: The mCCAO is a straightforward method of producing a CCH model in rats. It is associated with a low mortality rate and could potentially be used to investigate vascular disease, moyamoya disease, and CCH. This model was verified for an extended time point of 8 weeks after surgery.
ポジティブ思考の想像学習による社交不安低減法の神経基盤の解明

榊浩平, 榊浩平, 榊浩平, 野澤孝之, 池田純起, 川島隆太

日本心理学会大会発表論文集　82nd　(0)　524-524　2018年8月
出版者・発行元： (公社)日本心理学会
東日本大震災後の慢性疲労と他者との関わり合い

中川誠秀, 杉浦元亮, 関口敦, 事崎由佳, 荒木剛, 塙杉子, 宮内誠カルロス, 佐久間篤, 川島隆太

日本社会精神医学会雑誌　27　(3)　216-216　2018年8月
出版者・発行元： (一社)日本社会精神医学会
ISSN： 0919-1372
Bilinguals’ lexical access of cognates in the brain: Effects of language memberships 査読有り

Hsieh MC, Jeong H, Sugiura M, Kawashima R

Proceedings of The 20th Annual International Conference of the Japanese Society for Language Sciences,　34-37　2018年8月
OLIG2遺伝子多型(rs1059004)と統合失調症との関連、白質統合性、安静時脳灌流量及び認知機能への影響の検討

小松浩, 竹内光, 菊地淑恵, 小野千晶, 角藤芳久, 舩越俊一, 大野高志, 山森秀長, 安田由華, 藤本美智子, 畦地裕統, 工藤紀子, 川島隆太, 橋本亮太, 瀧靖之, 富田博秋

精神神経学雑誌　(2018特別号)　S656-S656　2018年6月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
MRI平均拡散率を用いた集団主義の神経基盤の同定

中川誠秀, 竹内光, 瀧靖之, 野内類, 事崎由佳, 品田貴光, 丸山司, 関口敦, 飯塚邦夫, 横山諒一, 山本悠貴, 塙杉子, 荒木剛, 宮内誠カルロス, Magistro Daniele, 榊浩平, 鄭嫣てい, 佐々木結咲子, 川島隆太

精神神経学雑誌　114th　(2018特別号)　S655-S655　2018年6月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
脳磁図は体性感覚誘発性棘波様活動を成人でも観察できる

石田誠, 菅野彰剛, 柿坂庸介, 神一敬, 上利大, 川島隆太, 中里信和

日本生体磁気学会誌　31　(1)　102-103　2018年6月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
読み聞かせ習慣と幼児の言語発達・問題行動および養育者のストレスとの関連

松崎泰, 池田純起, 川島隆太, 川島隆太, 川島隆太

日本コミュニケーション障害学会学術講演会予稿集　44th　2018年
自尊心の妬みとシャーデンフロイデ抑制作用の神経メカニズムの解明

山崎翔平, 杉浦元亮, 河田(サントスケルシ)人美, 佐々木結咲子, 野内類, 榊浩平, 池田純起, 川島隆太

日本ヒト脳機能マッピング学会プログラム・抄録集　20th　2018年
高齢者における自己の「死」とその恐怖への脳反応:fMRI研究

平野香南, 大場健太郎, 齊藤俊樹, 山崎翔平, 川島隆太, 杉浦元亮, 杉浦元亮

日本ヒト脳機能マッピング学会プログラム・抄録集　20th　75　2018年
fNIRSハイパースキャニングによる集団学習時の経験共有評価の可能性

野澤孝之, 近藤睦美, 山本玲子, JEONG Hyeonjeong, 池田純起, 榊浩平, 三宅美博, 石川保茂, 川島隆太

計測自動制御学会システムインテグレーション部門講演会(CD-ROM)　18th　ROMBUNNO.2B1‐03　2017年12月20日
IMPACT OF OLIG2 GENE VARIANT (RS1059004) ON WHITE MATTER TRACT INTEGRITY AND MEAN CEREBRAL BLOOD FLOW OF THE HUMAN BRAIN

Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Akira Kodaka, Shunichi Funakoshi, Takashi Ono, Yoshihisa Kakuto, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

EUROPEAN NEUROPSYCHOPHARMACOLOGY　27　S315-S316　2017年10月

ISSN： 0924-977X

eISSN： 1873-7862
肥満患者における食渇望の制御機能 fMRI研究

村椿智彦, 石垣泰, 鹿野理子, 関口敦, 澤田正二郎, 近藤敬一, 事崎由佳, 佐々木彩加, 森下城, 金澤素, 片桐秀樹, 川島隆太, 福土審

心身医学　57　(10)　1068-1068　2017年10月
出版者・発行元： (一社)日本心身医学会
ISSN： 0385-0307
乳がん手術前後の脳構造変化および認知機能障害縦断研究による検討

佐藤千穂, 関口敦, 事崎由佳, 野内類, 竹内光, 瀧靖之, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明

心身医学　57　(7)　761-761　2017年7月
出版者・発行元： (一社)日本心身医学会
ISSN： 0385-0307
沿岸部被災地在住の高齢女性たちに対する園芸療法介入の効果の検証

事崎由佳, 竹内光, 関口敦, 荒木剛, 山本悠貴, 品田貴光, Magistro Daniele, 十亀彩, 瀧靖之, 川島隆太

心身医学　57　(7)　761-762　2017年7月
出版者・発行元： (一社)日本心身医学会
ISSN： 0385-0307
マインドフルネスによる食渇望制御とその神経基盤 fMRI研究

村椿智彦, 鹿野理子, 関口敦, 石垣泰, 澤田正二郎, 近藤敬一, 事崎由佳, 佐々木彩加, 森下城, 金澤素, 片桐秀樹, 川島隆太, 福土審

心身医学　57　(7)　766-766　2017年7月
出版者・発行元： (一社)日本心身医学会
ISSN： 0385-0307
VBMと認知機能 (特集 Voxel-Based Morphometry : 体積からわかること)

竹内光, 川島隆太

Brain and nerve　69　(5)　547-556　2017年5月
出版者・発行元：医学書院
ISSN： 1881-6096
PRE-EXISTING SMALLER DLPFC VOLUME CONTRIBUTES TO POST-TRAUMATIC GROWTH AFTER A DISASTER IN CHILDREN

Atsushi Sekiguchi, Yuka Kotozaki, Thyreau Benjamin, Hikaru Takeuchi, Susumu Yokota, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

PSYCHOSOMATIC MEDICINE　79　(4)　A60-A61　2017年5月

ISSN： 0033-3174

eISSN： 1534-7796
提供された音のピッチに同調した発声を発している間の皮質活動-時間周波数解析を使用した脳磁図研究

NOMURA Yuri, KAWASE Tetsuaki, KANNO Akitake, NAKASATO Nobukazu, KAWASHIMA Ryuta, KATORI Yukio

日本生体磁気学会誌　30　(1)　2017年

ISSN： 0915-0374
歯周靭帯における体性感覚誘発性磁場

HIHARA Hiroki, KANETAKA Hiroyasu, KANNO Akitake, NAKASATO Nobukazu, KAWASHIMA Ryuta, SASAKI Keiichi

日本生体磁気学会誌　30　(1)　2017年

ISSN： 0915-0374
歯根膜刺激に対する大脳皮質の体性感覚誘発性応答

SHIMADA Eriya, KANETAKA Hiroyasu, KANNO Akitake, KANNO Akitake, KAWASHIMA Ryuta, NAKASATO Nobukazu, NAKASATO Nobukazu, IGARASHI Kaoru

日本生体磁気学会誌　30　(1)　2017年

ISSN： 0915-0374
脳磁図により特異的に検出される無症状発作

ISHIDA Makoto, KANNO Akitake, KANNO Akitake, KAKISAKA Yosuke, IWASAKI Masaki, JIN Kazutaka, KITAZAWA Yu, KAWASHIMA Ryuta, NAKASATO Nobukazu, NAKASATO Nobukazu

日本生体磁気学会誌　30　(1)　2017年

ISSN： 0915-0374
「他者との憩い経験」の回想を通じた自尊心向上による妬みとシャーデンフロイデへの抑制効果のfMRIを用いた検証

山崎翔平, 杉浦元亮, 河田(サントスケルシ)人美, 佐々木結咲子, 野内類, 榊浩平, 池田純起, 川島隆太

日本ヒト脳機能マッピング学会プログラム・抄録集　19th　2017年
大口蓋神経および舌神経電気刺激における大脳皮質反応の初期成分

小枝聡子, 日原大貴, 菅野彰剛, 川島隆太, 中里信和

日本生体磁気学会誌　30　(1)　170-171　2017年
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
大口蓋神経および舌神経電気刺激における大脳皮質反応の初期成分

小枝聡子, 日原大貴, 菅野彰剛, 川島隆太, 中里信和

日本生体磁気学会誌　30　(1)　170-171　2017年
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
身体リズム同調が教授・学習と脳活動同調に与える影響

野澤孝之, 榊浩平, 山崎翔平, 河田サントスケルシ人美, 河田サントスナタシャ百合子, 佐々木結咲子, 池田純起, KULASON Kay, 平野香南, JEONG Hyeonjeong, 川島隆太

計測自動制御学会システムインテグレーション部門講演会(CD-ROM)　17th　ROMBUNNO.1L4‐5　2016年12月15日
Neural Mechanisms and Children's Intellectual Development: Multiple Impacts of Environmental Factors

Hikaru Takeuchi, Ryuta Kawashima

NEUROSCIENTIST　22　(6)　618-631　2016年12月

DOI： 10.1177/1073858415610294 　

ISSN： 1073-8584

eISSN： 1089-4098
MRI-BASED CBF ANALYSIS TO PREDICT FUNCTIONAL OUTCOME AFTER MURINE EXPERIMENTAL SAH

Kazumasu Sasaki, Tatsushi Mutoh, Kazuhiro Nakamura, Ryuta Kawashima, Tatsuya Ishikawa

CRITICAL CARE MEDICINE　44　(12)　2016年12月

ISSN： 0090-3493

eISSN： 1530-0293
神経性やせ症患者の放線冠前部における白質線維統合性の低下

佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 橋爪寛, 遠藤由香, 庄司知隆, 田村太作, 町田知美, 町田貴胤, 河内山隆紀, 瀧靖之, 川島隆太, 福土審, 福土審

東北医学雑誌　128　(1)　64‐65　2016年6月25日

ISSN： 0040-8700
Association between mu-opioid receptor gene variant 118 A > G and personality traits among Japanese population

Yumiko Kubo, Hikaru Takeuchi, Yoshie Kikuchi, Yoshiyuki Kasahara, Zhiqian Yu, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　19　299-300　2016年6月

ISSN： 1461-1457

eISSN： 1469-5111
遊離前腕皮弁による舌再建術後の一次体性感覚誘発磁界反応

菅野彰剛, 小枝聡子, 柿坂庸介, 中里信和, 中里信和, 川島隆太, 杉浦元亮

日本生体磁気学会誌　29　(1)　90‐91-91　2016年6月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
Resting-State Connectivity between the MFC and right TPJ reflects a characteristic to avoid errors 査読有り

Miura N, Nozawa T, Takahashi M, Yokoyama R, Sasaki Y, Sakaki K, Kawashima R

The 22st Annual Meeting of the Organization for Human Brain Mapping　2016年6月
肥満症患者の灰白質容量とBMI、糖代謝指標との関係

村椿智彦, 鹿野理子, 石垣泰, 関口敦, 澤田正二郎, 近藤敬一, 事崎由佳, 佐々木彩加, 森下城, 金澤素, 片桐秀樹, 川島隆太, 福土審

心身医学　56　(6)　607-607　2016年6月
出版者・発行元： (一社)日本心身医学会
ISSN： 0385-0307
側頭葉てんかん患者における術前MEG言語機能マッピング

石田誠, 岩崎真樹, 菅野彰剛, 神一敬, 柿坂庸介, 川島隆太, 中里信和

日本生体磁気学会誌　29　(1)　128-129　2016年6月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
Erratum to Neural correlates of second-language communication and the effect of language anxiety [Neuropsychologia 66 (2015) 182-192], DOI: 10.1016/j.neuropsychologia.2014.11.013

Hyeonjeong Jeong, Motoaki Sugiura, Wataru Suzuki, Yuko Sassa, Hiroshi Hashizume, Ryuta Kawashima

Neuropsychologia　84　e1　2016年4月

DOI： 10.1016/j.neuropsychologia.2016.02.010 　

ISSN： 0028-3932

eISSN： 1873-3514
脳MRIを用いた初発乳癌術後半年の視床体積における神経可塑性の検討

佐藤千穂, 関口敦, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明

日本外科学会定期学術集会抄録集　116回　PS-012　2016年4月
出版者・発行元： (一社)日本外科学会
肥満患者における視覚刺激による食渇望の誘導

村椿智彦, 石垣泰, 金澤素, 鹿野理子, 森下城, 関口敦, 事崎由佳, 川島隆太, 片桐秀樹, 福土審

心身医学　56　(3)　278-279　2016年3月
出版者・発行元： (一社)日本心身医学会
ISSN： 0385-0307
MRI-based Non-invasive Assessment of Early Brain Injury and CBF for Functional Grading of Experimental Subarachnoid Hemorrhage in Mice

Kazumasu Sasaki, Kazuhiko Nakamura, Tomoko Mutoh, Ryuta Kawashima, Tatsuya Ishikawa, Tatsushi Mutoh

STROKE　47　2016年2月

ISSN： 0039-2499

eISSN： 1524-4628
弁証法的問題解決の神経基盤の解明

佐々木結咲子, 野澤孝之, 野澤孝之, 河田サントスケルシ人美, 池田純起, 榊浩平, 菊池達郎, 川島隆太, 川島隆太

日本ヒト脳機能マッピング学会プログラム・抄録集　18th　82　2016年
異文化接触による自己の再構築について―物語り論的視点に基づく海外留学推奨のための脳科学実験―

長谷部正, 長谷部正, 伊藤航平, 杉浦元享, 木谷忍, 木暮悠太, 小山田晋, 朴壽永, 山本悠貴, 塙杉子, 野内類, 野澤孝之, ジョンヒョンジョン, 川島隆太, 安江紘幸

日本感性工学会大会予稿集(CD-ROM)　18th　ROMBUNNO.A53　2016年
英語授業における脳活動同調評価の試み

野澤孝之, 山本玲子, 石川保茂, JEONG Hyeonjeong, 池田純起, 榊浩平, 川島隆太

計測自動制御学会システムインテグレーション部門講演会(CD-ROM)　16th　ROMBUNNO.2P3‐4　2015年12月14日
側頭葉てんかん患者におけるMEG言語機能局在診断

石田誠, 岩崎真樹, 菅野彰剛, 神一敬, 川島隆太, 中里信和

てんかん研究　33　(2)　596-596　2015年9月17日
出版者・発行元： (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Development of functional brain imaging modality by using animal 7T-MRI.

Akira Sumiyoshi, Ryuta Kawashima

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　146　(1)　40-6　2015年7月

DOI： 10.1254/fpj.146.40 　
BCIによる脳・機械の相互適応の促進

加納慎一郎, 川島隆太, 片山統裕, 三浦直樹

芝浦工業大学特別教育・研究報告集(CD-ROM)　2014　55-58　2015年6月30日

ISSN： 2185-7326
Neural bases of cognitive state which changes with own past behavior: an fMRI study 査読有り

Miura N, Nozawa T, Takahashi M, Yokoyama R, Sasaki Y, Sakaki K, Kawashima R

The 21st Annual Meeting of the Organization for Human Brain Mapping　2015年6月
An fMRI study on implicit and explicit second language knowledge modulated by task types and proficiency level

Jeong H, Ellis R, Suzuki W, Kashkouli Nejad K, Thyreau B, Magistro D, Yokoyama S, Kawashima R

Proceedings of The 17th Annual International Conference of the Japanese Society for Language SciencesProceedings of The 17th Annual International Conference of the Japanese Society for Language Sciences　162-163　2015年6月
体性感覚誘発性棘波様活動を脳磁図で検出した成人てんかん3例

石田誠, 柿坂庸介, 菅野彰剛, 岩崎真樹, 神一敬, 川島隆太, 中里信和

日本生体磁気学会誌　28　(1)　154-155　2015年6月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
時間周波数解析による体性感覚誘発磁界反応の評価は遷延性意識障害患者の機能残存の評価に有用である

菅野彰剛, 中里信和, 柿坂庸介, 長嶺義秀, 川島隆太

日本生体磁気学会誌　28　(1)　68-69　2015年6月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
その他脳MRIを用いた乳がん手術後の脳構造変化および認知機能障害の検討

佐藤千穂, 関口敦, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明

日本外科学会定期学術集会抄録集　115回　OP-242　2015年4月
出版者・発行元： (一社)日本外科学会
視覚情報提示による聴覚誘発磁界の変化視覚情報提示のタイミングの影響について

川瀬哲明, 高田志穂, 八幡湖, 高梨芳崇, 奥村有理, 菅野彰剛, 中里信和, 川島隆太, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　564-564　2015年4月
出版者・発行元： (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
コミュニケーション手段の違いが脳活動に与える影響の評価

野口茂明, 三浦直樹, 橋信, 川島隆太

平成 27 年東北地区若手研究者研究発表会　2015年2月
近赤外線分光法を用いた想定外事象に対峙したときの人間の脳活動解析

千葉幹, 増山直幸, 三浦直樹, 橋信, 川島隆太

平成 27 年東北地区若手研究者研究発表会　2015年2月
脳磁図のみで発作活動が記録された外傷性てんかんの一例

石田誠, 柿坂庸介, 神一敬, 岩崎真樹, 菅野彰剛, 加藤量広, 川島隆太, 中里信和

てんかん研究　32　(3)　618-619　2015年1月31日
出版者・発行元： (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
入浴環境の違いが脳活動に与える影響

松下大剛, 佐藤稔, 加藤智久, 菅野彰剛, 横山諒一, 川島隆太

日本感性工学会大会予稿集(CD-ROM)　17th　ROMBUNNO.B52　2015年
ピッチ認識を支える脳内神経基盤の解明

王凱, 王凱, 菅野彰剛, 横山悟, 川島隆太

日本ヒト脳機能マッピング学会プログラム・抄録集　17th　54　2015年
交通外傷後持続的植物状態患者および最小意識状態患者における体性感覚誘発磁界反応

菅野彰剛, 中里信和, 中里信和, 長嶺義秀, 川島隆太

日本ヒト脳機能マッピング学会プログラム・抄録集　17th　51　2015年
側頭葉てんかん患者におけるMEG言語マッピング

石田誠, 岩崎真樹, 菅野彰剛, 神一敬, 川島隆太, 中里信和

日本ヒト脳機能マッピング学会プログラム・抄録集　17th　68　2015年
Neural substrates representing temporal and motor sequences of rhythm

Naho Konoike, Yuka Kotozaki, Jeong Hyeonjeong, Atsuko Miyazaki, Kohei Sakaki, Takamitsu Shinada, Motoaki Sugiura, Ryuta Kawashima, Katsuki Nakamura

44th Annual meeting, Society for Neuroscience　2014年11月
てんかん治癒例における術前脳磁図

石田誠, 岩崎真樹, 神一敬, 柿坂庸介, 加藤量広, 菅野彰剛, 川島隆太, 中里信和

臨床神経生理学　42　(5)　289-289　2014年10月1日
出版者・発行元： (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
脳トレゲームは認知機能を向上させることができるのか?

野内類, 川島隆太

高次脳機能研究　34　(3)　335-341　2014年9月30日
出版者・発行元：一般社団法人日本高次脳機能障害学会
DOI： 10.2496/hbfr.34.335 　

ISSN： 1348-4818

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認知機能は, 私たちの日常生活や社会的な活動に重要な役割を担っている。しかしながら, 多くの認知機能は加齢とともに低下する。認知機能の低下は, 高齢者の様々な活動を困難にする原因となっている。そのため, 高齢者の認知機能を向上させる方法の一つである認知トレーニング研究に多くの注目が集まっている。本論文では, 認知トレーニングの中でも簡便に実施することのできる音読・計算トレーニングと脳トレゲームを用いた研究の成果を紹介した。脳トレゲームを用いた認知トレーニングは, 短期間で高齢者の実行機能と処理速度を向上させることが報告されている。そのため, 脳トレゲームは, 高齢者の認知機能の維持・向上に効果的なツールの一つであることを指摘した。最後に, 脳トレゲームを用いた認知トレーニングの今後の課題について検討した。
Decreased cerebral blood flow and BDNF levels are associated with depression and memory impairment in patients with heart failure -Brain Assessment and Investigation in Heart Failure Trial (B-HeFT)-

H. Suzuki, Y. Matsumoto, H. Ota, K. Sugimura, J. Takahashi, K. Ito, Y. Fukumoto, R. Kawashima, Y. Taki, H. Shimokawa

EUROPEAN HEART JOURNAL　35　13-13　2014年9月

ISSN： 0195-668X

eISSN： 1522-9645
NIRS装置を用いたインタフェース評価に関する研究 (3)超小型NIRS装置によるインタフェース評価可能性の検討

吉井慶人, 堀内友翔, 猪股礼寛, 三浦直樹, 高橋信, 川島隆太

ヒューマンインタフェース2014　2014年9月
NIRS装置を用いたインタフェース評価に関する研究(2)超小型NIRS装置を用いた同時計測による評価

小川剛史, 比嘉貴大, 堀内友翔, 三浦直樹, 高橋信, 川島隆太

ヒューマンインタフェース2014　2014年9月
NIRS装置を用いたインタフェース評価に関する研究(1)遠隔コミュニケーションの評価

渡邊琢磨, 秋澤由佳, 加納慎一郎, 高橋信, 三浦直樹, 川島隆太

ヒューマンインタフェース2014　2014年9月
舌電気刺激誘発脳磁界反応を用いた鼓索神経障害評価の可能性に関する検討

高梨芳崇, 川瀬哲明, 菅野彰剛, 八幡湖, 奥村有理, 山内大輔, 中里信和, 川島隆太, 香取幸夫

Otology Japan　24　(4)　407-407　2014年9月
出版者・発行元： (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
MINDFULNESS REDUCES CUE-INDUCED FOOD CRAVING: AN FMRI STUDY

T. Murastubaki, S. Fukudo, M. Kano, A. Sekiguchi, Y. Ishigaki, S. Sawada, K. Kondo, Y. Kotozaki, A. Sasaki, J. Morishita, M. Kanazawa, H. Katagiri, R. Kawashima

INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　21　S128-S128　2014年8月

ISSN： 1070-5503

eISSN： 1532-7558
アイロニー産出の脳メカニズム―脳磁図による検討―

秋元頼孝, 菅野彰剛, 杉浦元亮, 佐々木結咲子, 横山諒一, 浅野孝平, 宮澤志保, 川島隆太

日本心理学会大会発表論文集　78th　856　2014年8月
マインドフルネスと認知的再評価による食渇望制御とその神経基盤

村椿智彦, 鹿野理子, 関口敦, 石垣泰, 事崎由佳, 佐々木彩加, 森下城, 金澤素, 片桐秀樹, 川島隆太, 福土審

心身医学　54　(6)　569-569　2014年6月
出版者・発行元： (一社)日本心身医学会
ISSN： 0385-0307
Cognitive intervention through SAIDO Learning: A treatment for dementia. 査読有り

29th International Conference of Alzheimer’s Disease International　2014年5月
交通外傷後遷延性意識障害患者における体性感覚誘発磁界高周波振動

菅野彰剛, 中里信和, 長嶺義秀, 川島隆太

日本生体磁気学会誌　27　(1)　106-107　2014年5月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
マインドフルネスと認知的再評価による食渇望制御:fMRI研究

村椿智彦, 鹿野理子, 石垣泰, 関口敦, 澤田正二郎, 近藤敬一, 事崎由佳, 佐々木彩加, 森下城, 金澤素, 片桐秀樹, 川島隆太, 福土審

行動医学研究　20th　50　2014年3月

ISSN： 1341-6790
スマート・エイジング : 脳科学が創る超高齢社会の処方箋(特別講演(2))

川島隆太

バイオエンジニアリング講演会講演論文集　2014　(26)　3-3　2014年1月10日
出版者・発行元：一般社団法人日本機械学会
潜在的購買意図形成の神経基盤

横山諒一, 野澤孝之, 杉浦元亮, 蓬田幸人, 川島隆太

日本ヒト脳機能マッピング学会プログラム・抄録集　16th　70　2014年
てんかん外科におけるMEG言語マッピング

岩崎真樹, 菅野彰剛, 神一敬, 中里信和, 川島隆太, 冨永悌二

日本ヒト脳機能マッピング学会プログラム・抄録集　16th　52　2014年
被災地在住高齢女性への園芸介入による認知機能への影響

事崎由佳, 竹内光, 関口敦, 瀧靖之, 川島隆太

日本トラウマティック・ストレス学会大会プログラム・抄録集　13th　101　2014年
Neural correlates of simultaneous interpretation: The role of expertise and language proficiency 査読有り

Jeong H, Tatsumi K, Sugiura M, Kawashima R

Proceedings of The 16th Annual International Conference of the Japanese Society for Language Sciences　171-172　2014年
使える英語はコミュニケーション活動から【脳科学】授業に活かす言語学

鄭嫣婷, 川島隆太

英語教育　62　(10)　30-31　2013年12月
脳磁図棘波の信号源推定を用いた外傷性てんかんの診断

板橋泉, 神一敬, 岩崎真樹, 加藤量広, 板橋尚, 菅野彰剛, 冨永悌二, 川島隆太, 中里信和

てんかん研究　31　(2)　458-458　2013年9月30日
出版者・発行元： (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Structural abnormality of the hippocampus and depressive symptoms in a rat model of heart failure

H. Suzuki, A. Sumiyoshi, Y. Matsumoto, T. Yoshikawa, Y. Fukumoto, K. Yanai, Y. Taki, R. Kawashima, H. Shimokawa

EUROPEAN HEART JOURNAL　34　124-124　2013年8月

ISSN： 0195-668X

eISSN： 1522-9645
過敏性腸症候群における情動制御の神経基盤の検討

関口敦, 杉浦元亮, 川島隆太, 事崎由佳, 森下城, 相沢恵美子, 福土審

消化器心身医学　20　(1)　51-51　2013年8月
出版者・発行元：消化器心身医学研究会
ISSN： 1340-8844

eISSN： 2188-0549
Learning foreign language vocabularies from communicative context: an fMRI study 査読有り

Jeong H, Sugiura M, Yokoyama S, Hashizume H, Takahashi K, Thyreau B, Suzuki W, Kawashima R

Proceedings of The 15th Annual International Conference of the Japanese Society for Language Sciences　30-34　2013年7月
非侵襲的脳機能画像法による自発的な模倣の駆動に関わる神経基盤

塙杉子, 杉浦元亮, 事崎由佳, 出江紳一, 川島隆太

日本作業療法学会抄録集　47回　O181-O181　2013年6月
出版者・発行元： (一社)日本作業療法士協会
ISSN： 1880-6635
震災後精神症状の脆弱性・獲得因子の神経基盤の解明

関口敦, 杉浦元亮, 事崎由佳, 佐久間篤, 瀧靖之, 川島隆太

トラウマティック・ストレス　11　(1)　63-67　2013年6月
出版者・発行元： (一社)日本トラウマティック・ストレス学会
ISSN： 1348-0944
東日本大震災被災地在住の軽度PTSD症状の高齢女性たちに対する園芸療法介入

事崎由佳, 竹内光, 関口敦, 荒木剛, 山本悠貴, 品田貴光, MAGISTRO Daniele, 十亀彩, 瀧靖之, 川島隆太

日本トラウマティック・ストレス学会大会プログラム・抄録集　12th　112　2013年5月10日
震災前後に認められた脳形態変化の追跡調査

関口敦, 事崎由佳, 杉浦元亮, 塙杉子, 中川誠秀, 宮内カルロス誠, 佐久間篤, 瀧靖之, 川島隆太

日本トラウマティック・ストレス学会大会プログラム・抄録集　12th　114　2013年5月10日
PS-138-1 乳癌患者における術後認知機能障害の神経基盤の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

佐藤千穂, 関口敦, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明

日本外科学会雑誌　114　(2)　709-709　2013年3月5日
出版者・発行元：一般社団法人日本外科学会
ISSN： 1880-1129
PS-138-1 乳癌患者における術後認知機能障害の神経基盤の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

佐藤千穂, 関口敦, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明

日本外科学会雑誌　114　(2)　2013年3月5日
出版者・発行元：一般社団法人日本外科学会
ISSN： 0301-4894
小児における外国語音産出能力と脳形態の相関について

HASHIZUME Hiroshi, TAKI Yasuyuki, THYREAU Benjamin, SASSA Yuko, ASANO Michiko, ASANO Kohei, TAKEUCHI Hikaru, JEONG Hyeonjeong, SUGIURA Motoaki, KAWASHIMA Ryuta

日本神経化学会大会抄録集(Web)　56th　2013年
健常成人における性格と局所灰白質体積減少速度との相関

瀧靖之, THYREAY Thyreau, 木之村重男, 佐藤和則, 後藤了以, 川島隆太, 福田寛

日本老年医学会雑誌　50　(5)　2013年

ISSN： 0300-9173
神経性食思不振症患者の意思決定時における背外側前頭前皮質の活動亢進

佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 瀧靖之, 橋爪寛, 河内山隆紀, 川島隆太, 福土審

日本摂食障害学会学術集会プログラム・講演抄録集　17th　116　2013年
オプトジェネティクス（光遺伝学）による脳・神経系への情報送達

本城達也, 姫志剛, 横山超一, 住吉晃, 石塚徹, 川島隆太, 八尾寛

レーザー学会第437回研究報告「ニューロフォトニクス」　15-19　2012年12月
脳磁図を用いた聴覚性言語記憶課題による言語優位半球同定

菅野彰剛, 中里信和, 川島隆太

臨床神経生理学　40　(5)　410-410　2012年10月1日
出版者・発行元： (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
被災地在住の軽度PTSD症状の女性に対する園芸介入

事崎由佳, 荒木剛, 川島隆太

日本心理学会大会発表論文集　76回　347-347　2012年8月
出版者・発行元： (公社)日本心理学会
eISSN： 2433-7609
小児における外国語発音能力と外国語音産出に関わる脳活動の発達的変化の関係

橋爪寛, 瀧靖之, 佐々祐子, ティローバンジャマン, 浅野路子, 浅里孝平, 竹内光, 野内類, 事崎由佳, ジョンヒョンジョン, 杉浦元亮, 川島隆太

電子情報通信学会技術研究報告. TL, 思考と言語　112　(145)　19-23　2012年7月14日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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小児は、外国語音声を獲得するのに適している時期だと考えられているため、小児の外国語音声処理を明らかにすることは、外国語教育において有用である。我々は、6〜18歳の右利き健常日本人小児を対象に、機能的MRIを用いて、母国語にはない外国語の音声(1音節)を聞いて繰り返して発話する際の脳活動の発達的変化を調べた。本研究の結果から、成人対象の先行研究で、外国語音声を繰り返す際、言語音産出のための運動計画に関与するとされている左側下前頭回弁蓋部の活動が、年齢とともに増加することが分かった。外国語音声の発話精度も年齢とともに向上していたことから、左下前頭回弁蓋部の脳領域の発達が、外国語音声の即座の繰り返しの精度向上に反映している可能性がある。
脳磁気共鳴画像から見る健常小児の脳発達

瀧靖之, 川島隆太

小児の脳神経　37　(3)　223-231　2012年6月30日

ISSN： 0387-8023
標準脳へのspike mapping tool てんかんMEGの多角的分析を目指して

奥村栄一, 岩崎真樹, 菅野彰剛, 神一敬, 板橋尚, 大沢伸一郎, 加藤量広, 川島隆太, 中里信和

日本生体磁気学会誌　25　(1)　104-105　2012年6月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
小さな皮質形成異常に伴うてんかん棘波の信号源推定

板橋尚, 神一敬, 岩崎真樹, 奥村栄一, 菅野彰剛, 加藤量広, 冨永悌二, 川島隆太, 永井敏郎, 中里信和

日本生体磁気学会誌　25　(1)　106-107　2012年6月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
脳磁図解析法グループ解析

菅野彰剛, 秋元頼孝, 神原利宗, 杉浦元亮, 奥村栄一, 中里信和, 川島隆太

日本生体磁気学会誌　25　(1)　56-57　2012年6月
出版者・発行元：日本生体磁気学会
ISSN： 0915-0374
学習意欲の発達的変化と生活環境の影響

荒木剛, 杉浦元亮, 筒井健一郎, 池田和浩, 川島隆太

日本発達心理学会大会論文集　23rd　477　2012年2月1日
A GO intervention program for enhancing elementary school children's cognitive functions and control abilities of emotion and behavior: Study protocol for a randomized controlled trial 国際誌

Yoshiyuki Tachibana, Jiro Yoshida, Masahito Ichinomiya, Rui Nouchi, Carlos Miyauchi, Hikaru Takeuchi, Naoki Tomita, Hiroyuki Arai, Ryuta Kawashima

Trials　13　8-8　2012年1月12日

DOI： 10.1186/1745-6215-13-8 　
ヒト脳の正常発達・加齢に伴う脳形態およびネットワーク構造の変化-健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 瀧靖之, WU Kai, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 秋本達也, 川島隆太

ナノ医工学年報2011 東北大学グローバルCOEプログラム新世紀世界の成長焦点に築くナノ医工学拠点　2012年
健常成人の加齢における局所脳灰白質量の減少-383人の脳MRI解析による縦断研究-

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, WU Kai, 川島隆太, 福田寛

日本老年医学会雑誌　49　(5)　2012年

ISSN： 0300-9173
健常成人の高感度C反応性蛋白と局所脳灰白質量との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 福田寛, 川島隆太

日本医学放射線学会総会抄録集　71st　2012年

ISSN： 0048-0428
Neural substrates for maintenance of rhythm information 査読有り

Konoike N, Kotozaki Y, Miyachi S, Miyauchi CM, Yomogida Y, Akimoto Y, Kuraoka K, Sugiura M, Kawashima R, Nakamura K

The 35th Annual Meeting of the Japan Neuroscience Society (2012/09-18-21, Nagoya)　2012年
東日本大震災被災地在住のMild‐PTSD症状の女性たちに対する園芸療法介入

事崎由佳, 竹内光, 関口敦, 荒木剛, 川島隆太

日本トラウマティック・ストレス学会大会プログラム・抄録集　11th　98　2012年
震災後精神症状の脆弱性/獲得因子の神経基盤の解明

関口敦, 杉浦元亮, 事崎由佳, 佐久間篤, 川島隆太

日本トラウマティック・ストレス学会大会プログラム・抄録集　11th　101　2012年
神経性食思不振症患者の意思決定機能の脳機能画像的検討

佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 瀧靖之, 橋爪寛, 河内山隆紀, 川島隆太, 福土審

日本摂食障害学会学術集会プログラム・講演抄録集　16th　77　2012年
Evidence for Different Brain Processing from the Left and the Right Ventricles by Brain Functional MRI in Rats

Hideaki Suzuki, Akira Sumiyoshi, Ryuta Kawashima, Hiroaki Shimokawa

CIRCULATION　124　(21)　2011年11月

ISSN： 0009-7322
咀嚼は脳トレになるか?

川島隆太

日本顎口腔機能学会雑誌 = The Journal of Japanese Society of Stomatognathic Function　18　(1)　1-5　2011年10月30日

ISSN： 1340-9085
主観的幸福度の個人差による先延ばし行動若年者と高齢者との群間比較

事崎由佳, 野澤孝之, 川島隆太

日本心理学会大会発表論文集　75回　(0)　651-651　2011年8月
出版者・発行元： (公社)日本心理学会
DOI： 10.4992/pacjpa.75.0_1EV068 　

eISSN： 2433-7609
学習によって変化する語と感覚情報の連合に関与する神経基盤の解明査読有り

神原利宗, 月浦崇, 重宗弥生, 野内類, 蓬田幸人, 菅野彰剛, 川島隆太

言語科学会第13回年次国際大会 (JSLS 2011), 大阪　2011年6月
383人の健常成人の縦断研究による加齢及び脳血管障害危険因子と局所脳灰白質体積減少量との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, WU Kai, 川島隆太, 福田寛

日本医学放射線学会総会抄録集　70th　2011年

ISSN： 0048-0428
ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化-健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 滝靖之, WU Kai, 木之村重男, 佐藤和則, 井上健太郎, 後藤了以, 岡田賢, 川島隆太

ナノ医工学年報2010 東北大学グローバルCOEプログラム新世紀世界の成長焦点に築くナノ医工学拠点　2011年
中国・日本科学最前線-研究の現場から-2011年版医療における診断技術の研究開発「医療における診断技術の研究開発」-脳磁図の臨床応用

川島隆太, 川島隆太, 菅野彰剛

中国・日本科学最前線-研究の現場から 2011年版　2011年
Sparse and heterogeneous codification of sound attributes in rat primary auditory cortex revealed by laminar profile analysis

Takeshi Ogawa, Takakuni Goto, Akira Sumiyoshi, Hiroi Nonaka, Karim Jerbi, Olivier Bertrand, Ryuta Kawashima, Jorge Riera

NEUROSCIENCE RESEARCH　71　E149-E150　2011年

DOI： 10.1016/j.neures.2011.07.645 　

ISSN： 0168-0102
Gender differences in partial-volume corrected brain perfusion using brain MRI in healthy children

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Wu Kai, Rui Nouchi, Yuka Kotozaki, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

NEUROSCIENCE RESEARCH　71　E388-E388　2011年

DOI： 10.1016/j.neures.2011.07.1701 　

ISSN： 0168-0102
Sex difference in correlation between cognitive style and brain activity during visual delayed matching to sample task in children

Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Ryuta Kawashima

NEUROSCIENCE RESEARCH　71　E387-E388　2011年

DOI： 10.1016/j.neures.2011.07.1700 　

ISSN： 0168-0102
Localization of single barrel column by means of a volumetric current source density analysis in the somatosensory cortex of rat

Takakuni Goto, Takeshi Ogawa, Jorge Riera, Ryuta Kawashima

NEUROSCIENCE RESEARCH　71　E304-E305　2011年

DOI： 10.1016/j.neures.2011.07.1328 　

ISSN： 0168-0102
The overlapping community structure of structural brain network in young healthy individuals.

Wu Kai, Taki Yasuyuki, Sato Kazunori, Sassa Yuko, Inoue Kentaro, Goto Ryoi, Okada Ken, Kawashima Ryuta, He Yong, Evans Alan C, Fukuda Hiroshi

PLoS One　6　(5)　e19608-e19608　2011年

DOI： 10.1371/journal.pone.0019608 　

ISSN： 1932-6203
Lexical Categories and the Human Brain: An fMRI Study

Kambara T, S. Yokoyama, K. Takahashi, N. Miura, T. Miyamoto, D. Takahashi, S. Sato, R. Kawashima

Studies in Language Sciences　10　187-199　2011年
アイロニーの意図理解に関与する神経基盤::fMRI研究

秋元頼孝, 杉浦元亮, 蓬田幸人, 宮内誠カルロス, 宮澤志保, 川島隆太

日本心理学会大会発表論文集　75　(0)　3AM137-3AM137　2011年
出版者・発行元：公益社団法人日本心理学会
Different contributions of frontal, parietal, and temporal cortices to working memory of rhythm. 査読有り

Konoike N, Kotozaki Y, Miyachi S, Miyachi CM, Yomogida Y, Akimoto Y, Kuraoka K, Sugiura M, Kawashima R, Nakamura K

41th Annual meeting, Society for Neuroscience (2011/11, Washington, DC).　2011年
日本人脳画像データベースの解析による正常脳老化研究

福田寛, 瀧靖之, 呉凱, 川島隆太

電子情報通信学会技術研究報告. MI, 医用画像　110　(195)　61-64　2010年8月27日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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20歳代から70歳代までの健常な日本人2,500例の脳MRI画像データベースを構築し、これを材料として脳の加齢変化の解析を行った。脳灰白質容積は20歳代からほぼ直線的に減少するが、白質容積は50歳代まで徐々に増加して、その後減少に転じた。次に平均7年間隔で二度MRIを撮像した383例の灰白質容積の変化を解析し、灰白質容積は、女性では50歳代まで男性よりゆるやかに減少することがわかった。また、脳の解剖学的標準化の手法を用いて、集団に属する多数の脳の平均的な形態を反映する"標準脳"を作成した。さらに脳局所灰白質量を指標としてグラフ理論に基づくネットワーク解析を行い、small worldnessやmodularityなどのネットワーク特性が年齢(若年、中年、老年)で異なることを明らかにした。
報酬と罰がエピソード記憶の想起に与える影響(Effects of monetary reward and punishment on neural activations during successful retrieval of source memories)

重宗弥生, 月浦崇, 神原利宗, 川島隆太

神経化学　49　(2-3)　486-486　2010年8月
出版者・発行元：日本神経化学会
ISSN： 0037-3796
勤労者を対象にしたバイオフィードバックトレーニングによるストレス軽減効果

事崎由佳, 荻野武, 川島隆太

日本心理学会大会発表論文集　74回　(0)　1297-1297　2010年8月
出版者・発行元： (公社)日本心理学会
DOI： 10.4992/pacjpa.74.0_1PM020 　

eISSN： 2433-7609
274人の健常小児を対象にした、年齢と灰白質体積との相関(Relationship between gray matter volume and age in 274 healthy Japanese children applying voxel-based morphometric analysis)

瀧靖之, 橋爪寛, 佐々祐子, 竹内光, Kai Wu, 野内類, 事崎由佳, 浅野孝平, 浅野路子, 福田寛, 川島隆太

神経化学　49　(2-3)　484-484　2010年8月
出版者・発行元：日本神経化学会
ISSN： 0037-3796
人物に関する記憶の記銘時の神経活動に対する加齢の効果(Age-related differences in brain activity during successful encoding of memory for person identity information)

月浦崇, 重宗弥生, 神原利宗, 関口敦, 蓬田幸人, 中川誠秀, 秋月祐子, 瀧靖之, 川島隆太

神経化学　49　(2-3)　664-664　2010年8月
出版者・発行元：日本神経化学会
ISSN： 0037-3796
側頭頭頂領域における視覚的社会情報処理の機能解剖(Functional anatomy of visuosocial processing in temporo-parietal region)

杉浦元亮, 蓬田幸人, 間野陽子, 佐々祐子, 神原利宗, 関口敦, 川島隆太

神経化学　49　(2-3)　749-749　2010年8月
出版者・発行元：日本神経化学会
ISSN： 0037-3796
Age-dependency in brain activation involved with imitation of unfamiliar foreign language sound: an fMRI study

HASHIZUME Hiroshi, TAKI Yasuyuki, SASSA Yuko, ASANO Michiko, ASANO Kohei, TAKEUCHI Hikaru, JEONG Hyeonjeong, SUGIURA Motoaki, KAWASHIMA Ryuta

神経化学　49　(2/3)　664　2010年8月1日

ISSN： 0037-3796
Cortical activity with reflexological stimulation is unaffected by pseudo information: An fMRI study, 査読有り

Miura N, Akitsuki Y, Sekiguchi A, Kawashima R

16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona,　2010年6月
Neural activations associated with the effect of monetary rewards on intrinsic motivation 査読有り

Miki K, Sekiguchi A, Sugiura M, Akitsuki Y, Tsukiura T, Yomogida Y, Kawashima R

16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain　2010年6月
ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化-健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 滝靖之, WU Kai, 木之村重男, 佐藤和則, 井上健太郎, 後藤了以, 岡田賢, 川島隆太

ナノ医工学年報2009 東北大学グローバルCOEプログラム新世紀世界の成長焦点に築くナノ医工学拠点　2010年
Effects of monetary reward and punishment on neural

Yayoi Shigemune, Takashi Tsukiura, Toshimune Kambara, Ryuta Kawashima

NEUROSCIENCE RESEARCH　68　E69-E69　2010年

DOI： 10.1016/j.neures.2010.07.070 　

ISSN： 0168-0102
IMPROVING COGNITIVE FUNCTIONS OF SENIORS BY READING AND SOLVING ARITHMETIC PROBLEMS 査読有り

K. Nakamura, M. Taira, R. Kawashima

EUROPEAN PSYCHIATRY　25　2010年

ISSN： 0924-9338
有効視野拡大訓練に伴う脳活動の変化

西村聡生, 月浦崇, 荻谷光晴, 木村賢治, 飯島敏夫, 川島隆太, 塩入諭, 筒井健一郎

基礎心理学研究　28　(2)　2010年

ISSN： 0287-7651
Relationship between gray matter volume and age in 274 healthy Japanese children applying voxel-based morphometric analysis

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Wu Kai, Rui Nouchi, Yuka Kotozaki, Kohei Asano, Michiko Asano, Hiroshi Fukuda, Ryuta Kawashima

NEUROSCIENCE RESEARCH　68　E65-E66　2010年

DOI： 10.1016/j.neures.2010.07.056 　

ISSN： 0168-0102
A critical view of the dipolar model in the neocortex

Jorge Riera, Takakuni Goto, Takeshi Ogawa, Akira Sumiyoshi, Hiroi Nonaka, Akitake Kanno, Kazuyuki Kose, Hiroyoshi Miyakawa, Ryuta Kawashima

NEUROSCIENCE RESEARCH　68　E331-E331　2010年

DOI： 10.1016/j.neures.2010.07.1469 　

ISSN： 0168-0102
Correlation between cognitive style and brain activity in visual delayed matching task in children

Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Ryuta Kawashima

NEUROSCIENCE RESEARCH　68　E295-E296　2010年

DOI： 10.1016/j.neures.2010.07.1312 　

ISSN： 0168-0102
A volumetric current source density analysis with realistic geometrical properties and conductivity profiles in the somatosensory cortex of rats

Takakuni Goto, Takeshi Ogawa, Jorge Riera, Ryuta Kawashima

NEUROSCIENCE RESEARCH　68　E440-E440　2010年

DOI： 10.1016/j.neures.2010.07.1949 　

ISSN： 0168-0102
運動イメージ時の脳活動におけるNIRS信号を用いたニューロフィードバックの効果 : fMRIによる評価

Susila I. Putu, 加納慎一郎, 宮本浩一郎, 吉信達夫, 川島隆太

電子情報通信学会技術研究報告. NC, ニューロコンピューティング　109　(280)　65-70　2009年11月5日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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右手の運動イメージの課題遂行中に近赤外分光法(NIRS)によって計測された脳活動信号をユーザにフィードバックするオンラインフィードバック訓練実験を5日間にわたって実施し,その効果を定量化するために,訓練開始前と終了後の脳活動をfMRIで計測した.5名中3名の被験者では,運動イメージに伴って賦活される脳領域が訓練の実施によって補足運動野,運動野,および小脳において限局的となることが示された.また,補足運動野および手足に関連する運動野の領域において関心領域(VOI)を設けて運動イメージによって生じるBOLD信号の時間変化を評価した.この3名の被験者に対して別途実施したNIRS計測実験の結果では運動イメージ中の酸化ヘモグロビン量の積分値が訓練の実施に伴い増加したが,本実験では,この3名のうち2名の被験者で訓練後にBOLD信号のピーク値および積分値が小さくなった.
運動イメージ時の脳活動におけるNIRS信号を用いたニューロフィードバックの効果 : NIRSによる評価

飯塚慶, 加納慎一郎, 宮本浩一郎, 吉信達夫, 川島隆太

電子情報通信学会技術研究報告. NC, ニューロコンピューティング　109　(280)　59-64　2009年11月5日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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NIRS(近赤外分光法)による脳血流測定法を用いて計測した大脳運動野の活動情報を利用したBCI(brain-computer interface)システムにおいて,ニューロフィードバックトレーニングを被験者に実施した際の効果を検討した.手の動作のイメージを行う5名の被験者の運動野近傍での酸化ヘモグロビン濃度分布をNIRSシステムで計測し,応答信号の振幅を視覚的にオンラインで提示した.本実験の結果,5名中2名の被験者で訓練の効果が認められた.より効果的なトレーニング方法,フィードバック手法の検討が今後の課題である.
Effects of aging on anterior temporal and hippocampal activations during successful retrieval of memory for person identity information 査読有り

Tsukiura T, Sekiguchi A, Yomogida Y, Nakagawa S, Akitsuki Y, Taki Y, Kawashima R

The 39th Annual Meeting of Society for Neuroscience, Chicago, USA　2009年10月
Anatomy of episodic context: distinct neural bases for item-roles and item integration 査読有り

Sugiura M, Yomogida Y, Mano Y, Kambara T, Sekiguchi A, Tsukiura T, Kawashima R

The 39th Annual Meeting of Society for Neuroscience, Chicago, USA　2009年10月
Neural correlates of social interaction and concern for other person in episodic memory: an fMRI study 査読有り

間野陽子, 杉浦元亮, 月浦崇, 蓬田幸人, ジョンヒョンジョン, 関口敦, 秋月祐子, 川島隆太

第32回日本神経科学学会総会，名古屋　2009年9月
エピソード記憶におけるソーシャル・インタラクションの影響:fMRI研究

間野陽子, 杉浦元亮, 月浦崇, 蓬田幸人, JEONG Hyeonjeong, 関口敦, 秋月祐子, 川島隆太

日本心理学会大会発表論文集　73rd　546　2009年8月
Pulse wave velocity (PWV) と Cardio Ankle Vascular Index (CAVI) ―数理モデルから臨床、予防医学への展開―

山家智之, 白石泰之, 今野敏, 劉紅箭, 川島隆太, 吉澤誠, 早瀬敏幸, 阿部恒之, ビクター・ミラーゲン, ユーリ・コバレフ, イリーナ・ミリャジーナ, 侯暁彫, 張秀敏

日本臨床生理学会雑誌　39　(4)　189-213　2009年7月
出版者・発行元：日本臨床生理学会
Contribution of the bilateral middle temporal gyri to the processing of lexical categories

Tachibana K, Suzuki K, Mori E, Miura N, Kawashima R, Horie K, Sato S, Tanji J, Muchiake H

The annual meeting of the cognitive science society　2009年7月
NIRSによる運動イメージ時の脳血流分布計測を用いたBCIシステム : システム開発とオンラインフィードバックトレーニング

加納慎一郎, 村山結美, 宮本浩一郎, 吉信達夫, 川島隆太

電子情報通信学会技術研究報告. NC, ニューロコンピューティング　108　(480)　375-380　2009年3月4日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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NIRS(近赤外線分光法)による脳血流計測法を用いて大脳運動野の活動を計測し,それから運動のイメージの種類や有無を検出するBCI(brain-computer interface)システムを構築し,オンラインフィードバックトレーニングを被験者に実施した際の効果について検討した.右手の動作のイメージを行う3名の被験者の運動野近傍の酸化ヘモグロビン濃度分布を52チャネルNIRSシステムで計測し,国際10-20法における脳波計測部位C3近傍の応答信号の振幅を視覚的に被験者にオンラインで提示した.本実験の結果,3名中2名の被験者で,右手動作のイメージによって生じる脳血流信号のS/N比が5回のトレーニングで向上した.トレーニングの実施による脳活動の変化の詳細の検討が今後の課題である.
運動制御動作の獲得過程における自発的拘束と機能創発

後藤太邦, 本間経康, 川島隆太

計測と制御 = Journal of the Society of Instrument and Control Engineers　48　(1)　100-105　2009年1月10日
出版者・発行元：計測自動制御学会
ISSN： 0453-4662
年齢相応の脳発達とは?

瀧靖之, 橋爪寛, 佐々祐子, 木之村重男, 後藤了以, 佐藤和則, 福田寛, 川島隆太

日本医学放射線学会総会抄録集　68th　2009年

ISSN： 0048-0428
Developmental neural networks in children performing Go/NoGo task: an fMRI study with wide age range

Hiroshi Hashizume, Yasuyuki Taki, Yuko Sassa, Michiko Asano, Kohei Asano, Hikaru Takeuchi, Mijin Lee, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S240-S240　2009年

DOI： 10.1016/j.neures.2009.09.1359 　

ISSN： 0168-0102
Voxel-based morphometry of the relationships between Intelligence Quotient and brain gray matter volume in 156 healthy Japanese children

Michiko Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kohei Asano, Mijin Lee, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S226-S226　2009年

DOI： 10.1016/j.neures.2009.09.1262 　

ISSN： 0168-0102
alpha 2*NICOTINIC ACETHYLCHOLINE RECEPTORS AND LTP INDUCTION IN THE HIPPOCAMPAL CA1 REGION

Sakura Nakauchi, Jorge Riera, Ryuta Kawashima, Katumi Sumikawa

JOURNAL OF PHYSIOLOGICAL SCIENCES　59　186-186　2009年

ISSN： 1880-6546
Correlation between brain activity during delayed matching task and verbal IQ in healthy children

Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Michiko Asano, Mijin Lee, Hikaru Takeuchi, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S241-S241　2009年

DOI： 10.1016/j.neures.2009.09.1360 　

ISSN： 0168-0102
Relationship between gray matter volume and age in 156 healthy Japanese children: Volumetric analysis and voxel-based morphometry

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Mijin Lee, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S225-S225　2009年

DOI： 10.1016/j.neures.2009.09.1261 　

ISSN： 0168-0102
脳科学と社会

川島隆太

東北医学雑誌　120　(2)　165-168　2008年12月25日
出版者・発行元：東北医学会
ISSN： 0040-8700
聴覚刺激に対する選択的注意を利用した Brain-Computer Interface の開発

雑賀広記, 三浦直樹, 川島隆太, 王碩玉

電気学会研究会資料. MBE, 医用・生体工学研究会　2008　(49)　31-34　2008年10月24日
脚運動時の脳-筋肉活動間の関連性解析 : 機能的近赤外線分光法による研究

天野敬介, 三浦直樹, 川島隆太, 王碩玉

電気学会研究会資料. MBE, 医用・生体工学研究会　2008　(49)　63-66　2008年10月24日
脚運動時の脳-筋肉活動間の関連性解析 : 機能的近赤外線分光法による研究

天野敬介, 三浦直樹, 川島隆太, 王碩玉

電子情報通信学会技術研究報告. NC, ニューロコンピューティング　108　(264)　117-120　2008年10月16日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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近年,脳の可塑性に関する知見に基づくニューロリハビリテーション手法が盛んに研究されている.本研究では,脳科学的知見を歩行リハビリテーションに導入するための基礎研究として,脚運動動作の基礎となる座位から立位への移行動作過程における脳血流動態反応について,機能的近赤外線分光法を用いて計測を行い,各動作時の計測における脳血流動態反応と脚の筋肉活動との関係性について検討した.その結果,姿勢移行に伴う脚部の筋活動の増加に対応して内側感覚運動野の脳血流が増加する事が観察された.
聴覚刺激に対する選択的注意を利用した Brain-Computer Interface の開発

雑賀広記, 三浦直樹, 川島隆太, 王碩玉

電子情報通信学会技術研究報告. NC, ニューロコンピューティング　108　(264)　85-88　2008年10月16日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

詳細を見る詳細を閉じる

聴覚刺激に対する脳活動を利用したBrain-Computer Interface (BCI)を開発するための基礎研究として,歌の歌詞または旋律のいずれかに対して選択的に注意を向けた際の左右側聴覚野及び言語野周辺領域の脳血流動態反応について,近赤外線分光法を用いて計測を行った.注意の向け方による左右側聴覚野の反応の変化から,BCI入力信号としての利用可能性について検討した.
脳を鍛えて安全運転 : 安全運転と脳機能の関連

川島隆太

自動車技術 = Journal of Society of Automotive Engineers of Japan　62　(7)　4-5　2008年7月1日

ISSN： 0385-7298
fMRIを用いた知的興奮に関する脳ネットワークの同定

福島愛, 杉浦元亮, 三浦直樹, 内田信也, 川島隆太

第10回日本ヒト脳機能マッピング学会　2008年6月
An fMRI Study of Word Category on Word Recognition 査読有り

Kambara T, Yokoyama S, Takahashi K, Miura N, Miyamoto T, Takahashi D, Sato S, Kawashima R

14th Annual Meeting of the Organization for Human Brain Mapping　2008年6月
An fMRI Study of syntactic information on word recognition 査読有り

Kambara T, Yokoyama S, Takahashi K, Miura N, Miyamoto T, Takahashi D, Sato S, Kawashima R

14th Annual Meeting of the Organization for Human Brain Mapping　2008年6月
FMRI study on risk perception for driving task presented as video images 査読有り

Takahashi M, Aboshi T, Miura N, Ota H, Kawashima R, Wakabayashi T

14th Annual Meeting of the Organization for Human Brain Mapping　2008年6月
Top-down facilitation of visual object recognition 査読有り

Taminato T, Miura N, Sugiura M, Kawashima R

14th Annual Meeting of the Organization for Human Brain Mapping　2008年6月
A somatotopical relationship between cortical activity and reflexological stimulation: an fMRI study 査読有り

Nakamaru T, Miura N, Fukushima A, Kawashima R

14th Annual Meeting of the Organization for Human Brain Mapping　2008年6月
The effect of body structure of humanoid robot for emotional empathy: an fMRI study 査読有り

Miura N, Sugiura M, Takahashi M, Moridaira T, Miyamoto A, Kuroki Y, Kawashima R

14th Annual Meeting of the Organization for Human Brain Mapping　2008年6月
The action of bipedal humanoid robot strongly induces emotional brain responses: a neuroimaging approach 査読有り

Miura N, Sugiura M, Takahashi M, Moridaira T, Miyamoto A, Kuroki Y, Kawashima R

3rd ACM/IEEE International Conference on Human-Robot Interaction　2008年3月
語彙認知過程における修飾情報と叙述情報の脳内処理

神原利宗, 横山悟, 高橋慶, 三浦直樹, 宮本正夫, 高橋大厚, 佐藤滋, 川島隆太

言語処理学会第14回年次大会　2008年3月
加齢による灰白質体積の減少は男性が女性よりも早い-382人の脳MRI解析による縦断研究-

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会総会抄録集　67th　2008年

ISSN： 0048-0428
Astrocytic Ca2+ waves and sustained functional hyperemia

Jorge Riera, H. G. Enjieu Kadji, Takeshi Ogawa, Morito Rieke, Takakuni Goto, Ryuta Kawashima

NEUROSCIENCE RESEARCH　61　S49-S49　2008年

ISSN： 0168-0102
Microscopic conductivity profile in the cerebral cortex of Wistar rats

Takakuni Goto, Takeshi Ogawa, H. G. Enjieu Kadji, Ryuta Kawashima, Jorge Riera

NEUROSCIENCE RESEARCH　61　S140-S140　2008年

ISSN： 0168-0102
Lexicall Processing of Modification and Predication

神原利宗, 横山悟, 高橋慶, 三浦直樹, 宮本正夫, 高橋大厚, 佐藤滋, 川島隆太

言語処理学会第14回年次大会発表論文集　B5-8　1061-1064　2008年
内容語の語彙情報に関するfMRI手法を用いた脳科学的分析

神原利宗, 横山悟, 高橋慶, 三浦直樹, 宮本正夫, 高橋大厚, 佐藤滋, 川島隆太

言語科学会第10回年次国際大会JSLS2008論文集　JSLS2008　81-84　2008年
Neural mechanisms underlying a face-to-face interview in the second language 査読有り

Jeong H, Hashizume H, Sassa Y, Yokoyama S, Nakamura K, Sugiura M, Kawashima R

Neuroscience Research　61　(Supplement 1)　S199　2008年
Cortical mechanism of ideal self _ an fMRI study 査読有り

Fukushima A, Miura N, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月
Cortical networks sensitive to the difference in motion and appearance of humanoid robot and human: an fMRI study. 査読有り

Miura N, Sugiura M, Takahashi M, Sassa Y, Moridaira T, Miyamoto A, Kuroki Y, Sato S, Horie K, Nakamura K, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月
認知リハビリテーション医学‐認知症に対する学習療法 (BRAIN and NERVE)

関口敦, 川島隆太

BRAIN and NERVE　59　(4)　357-365　2007年4月
認知症の脳科学 (心療内科)

立花良之, 川島隆太

心療内科　11　(1)　19-24　2007年1月28日
加齢に伴う脳灰白質体積の経時変化-健常被験者の脳MRI解析による8年間の縦断研究第一報-

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会学術集会抄録集　66th　2007年

ISSN： 0048-0428
Body Mass Indexと全脳及び局所灰白質量との相関-1428人の脳MR画像を用いたvoxel-based morphometryによる解析-

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 川島隆太

日本医学放射線学会秋季臨床大会抄録集　43rd　2007年

ISSN： 0048-0428
Nonlinear local neurovascular coupling in the cerebral cortex

Jorge J. Riera, Juan C. Jimenez, Tohru Ozaki, Ryuta Kawashima, Xiaohong Wan

NEUROSCIENCE RESEARCH　58　S129-S129　2007年

ISSN： 0168-0102
Changes of the brain activity related to the differences in manner of articulation

Shinya Uchida, Naoki Miura, Katsuki Nakamura, Kazunori Sato, Hiroshi Fukuda, Ryuta Kawashima

NEUROSCIENCE RESEARCH　58　S174-S174　2007年

ISSN： 0168-0102
健常高齢者における全脳及び局所灰白質量と認知力との相関 volumetry及びvoxel-based morphometryによる解析 (日本老年医学会雑誌)

瀧靖之, 木之村重男, 佐藤和則, 内田信也, 後藤了以, 井上健太郎, 辻一郎, 荒井啓行, 川島隆太, 福田寛

日本老年医学会雑誌　44　(1)　138-138　2007年1月
fMRI evidence for distinct neural mechanisms between the lexical and sentence processing: the case of the processing of passives.

Yokoyama, S, K. Yoshimoto, T. Miyamoto, K. Horie, S. Sato, R. Kawashima

NeuroImage: The 13th Annual Meeting of the Organizaion of Human Brain Mapping, June 10-14. Chicago.　36　(Supplement 1)　124 M-PM-　2007年
A longitudinal fMRI study of neural plasticity in the second language lexical processing.

Satoru Yokoyama, Jungho Kim, Shinya Uchida, Hideyuki Okamoto, Chen Bai, Noriaki Yusa, Tadao Miyamoto, Kei Yoshimoto, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

The 30th Meeting of the Japan Neuroscience Society, Yokohama, September 10-12　P2-h31　2007年
Cortical Mechanisms of Segmentation in Japanese Auditory Sentence Comprehension.

Oshima, H, H. Jeong, M. Sugiura, T. Miyamoto, Y. Sassa, K. Wakusawa, K. Horie, S. Sato, R. Kawashima

NeuroImage: The 13th Annual Meeting of the Organizaion of Human Brain Mapping, June 10-14. Chicago.　36　(Supplement 1)　104 M-PM-　2007年
視覚単語認識中の意味アクセスへの二つの異なる神経回路網査読有り

Jeong, H, Sugiura M, Sassa Y, Miyamoto T, Horie K, Sato S, Kawashima, R

神経化学　(46)　554　2007年
新しい知識を獲得するときの興味に関する脳機能イメージング研究

福島愛, 三浦直樹, 内田信也, 杉浦元亮, 堀江薫, 佐藤滋, 川島隆太

第２８回日本神経科学大会　2006年7月
言語関連領野の神経線維連絡：機能的MRIと拡散テンソル画像による検討

内田信也, 三浦直樹, 渡邉丈夫, 木之村重男, 佐藤和則, 瀧靖之, 井上健太郎, 後藤了以, 岡田賢, 福島愛, 堀江薫, 佐藤滋, 中村克樹, 福田寛, 川島隆太

第２８回日本神経科学大会　2006年7月
計器監視課題における難易度の影響：fMRIによる研究

三浦直樹, 高橋信, 渡邉丈夫, 内田信也, 佐藤滋, 堀江薫, 北村正晴, 若林利男, 中村克樹, 川島隆太

第２８回日本神経科学大会　2006年7月
情動形成とその異常の脳内機構情動と心身相関のBlack Boxに迫る身体感覚から情動形成に至る脳内過程とその異常 (心身医学)

福土審, 濱口豊太, 鹿野理子, 渡辺諭史, 水野資子, 金澤素, 中谷久美, 相模泰宏, 庄司知隆, 遠藤由香, 青木正志, 糸山泰人, 川島隆太, 伊藤正敏, 谷内一彦, 本郷道夫

心身医学　46　(6)　469-469　2006年6月
Universal Grammar and Instruction Effects on Second Language Grammar Formation: Evidence from fMRI 査読有り

Yusa N, Koizumi M, Kim J, Saki Y, Kimura N, Uchida S, Yokoyama S, Miura N, Horie K, Sato S, Kawashima R, Hagiwara H

12th International Conference on Functional Mapping of the Human Brain　2006年6月
Impact of serotonin transporter gene on negative emotion and brain processing during fear conditioning: an event-related fMRI study 査読有り

Mizuno T, Sugiura M, Kano M, Miura N, Watanabe J, Hattori T, Sato S, Horie K, Aoki M, Itoyama Y, Kawashima R, Fukudo S

12th International Conference on Functional Mapping of the Human Brain　2006年6月
Neural correlates of confidence judgment in retrieved answers: An fMRI study 査読有り

Yokoyama O, Miura N, Watanabe J, Takemoto A, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R, Nakamura K

12th International Conference on Functional Mapping of the Human Brain　2006年6月
Cortical activation related to intellectual excitement 査読有り

Fukushima A, Miura N, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R

12th International Conference on Functional Mapping of the Human Brain　2006年6月
Neural connectivity among regions related to language function: combined intersubject analysis by functional magnetic resonance imaging and diffusion tensor imaging tractography. 査読有り

Uchida S, Miura N, Watanabe J, Kinomura S, Sato K, Taki Y, Inoue K, Goto R, Okada K, Fukuda H, Kawashima R

12th International Conference on Functional Mapping of the Human Brain　2006年6月
A relevant analysis of task difficulty and brain activity during meter inspection: an fMRI study 査読有り

Miura N, Takahashi M, Watanabe J, Uchida S, Sato S, Horie K, Kitamura M, Wakabayashi T, Nakamura K, Kawashima R

12th International Conference on Functional Mapping of the Human Brain　2006年6月
Effect of motion smoothness on brain activation during dance observation: an fMRI study using a humanoid robot. 査読有り

Miura N, Sugiura M, Takahashi M, Sassa Y, Moridaira T, Miyamoto A, Kuroki Y, Sato S, Horie K, Nakamura K, Kawashima R

12th International Conference on Functional Mapping of the Human Brain　2006年6月
画像でみる高次脳機能体性感覚性認知指し示す(kinesthesia) PETによる局在(図説) (Clinical Neuroscience)

井上健太郎, 川島隆太, 福田寛

Clinical Neuroscience　24　374-375　2006年4月
ブレインインフォマティクスと加齢疾患 (生化学)

川島隆太

生化学　78　(3)　262-266　2006年3月
各種の予防認知刺激 (Progress in Medicine)

川島隆太

Progress in Medicine　26　(2)　397-400　2006年2月
大脳,小脳の各解剖学的構造における局所灰白質量と年齢との相関-1460人の脳MRIを用いたROI解析-

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 小野修一, 川島隆太

日本医学放射線学会秋季臨床大会抄録集　42nd　2006年

ISSN： 0048-0428
Neural connectivity among brain areas related to language function

Shinya Uchida, Naoki Miura, John Watanabe, Shigeo Kinomura, Kazunori Sato, Yasuyuki Taki, Kentaro Inoue, Ryoi Goto, Ai Fukushima, Kaoru Horie, Shigeru Sato, Katsuki Nakamura, Hiroshi Fukuda, Ryuta Kawashima

NEUROSCIENCE RESEARCH　55　S263-S263　2006年

ISSN： 0168-0102
Correlation between semantic memory and regional gray matter volume of anterior aspect of right temporal lobe in normal elderly subjects. A voxel-based morphometry

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Shinya Uchida, Ryoi Goto, Kentaro Inoue, Ichiro Tsuji, Hiroyuki Arai, Ryuta Kawashima, Hiroshi Fukuda

NEUROSCIENCE RESEARCH　55　S103-S103　2006年

ISSN： 0168-0102
Distinct neural substrates for word recognition between L1 and L2

Satoru Yokoyama, Jungho Kim, Shin-ya Uchida, Hideyuki Okamoto, Chen Bai, Tadao Miyamoto, Kei Yoshimoto, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

NEUROSCIENCE RESEARCH　55　S131-S131　2006年

ISSN： 0168-0102
Cortical activations correlated to cognitive trait during experience of risky situation: An fMRI study

Atsushi Sekiguchi, Naho Ikuta, Motoald Sugiura, Hideyuki Okamoto, Shigeru Satou, Kaoru Horie, Ryuta Kawashima

NEUROSCIENCE RESEARCH　55　S132-S132　2006年

ISSN： 0168-0102
A model selection of GLM applied to fMRI data using AlC

Jobu Watanabe, Fumikazu Miwakeichi, Andreas Galka, Ryuta Kawashima, Tohru Ozaki, Sunao Uchida

NEUROSCIENCE RESEARCH　55　S260-S260　2006年

ISSN： 0168-0102
Both global gray matter volume and regional gray matter volume negatively correlate with lifetime alcohol intake in non-alcohol-dependent Japanese men: a volumetric analysis and a voxel-based morphometry.

Taki Yasuyuki, Kinomura Shigeo, Sato Kazunori, Goto Ryoi, Inoue Kentaro, Okada Ken, Ono Shuichi, Kawashima Ryuta, Fukuda Hiroshi

Alcohol Clin Exp Res　30　(6)　1045-1050　2006年

DOI： 10.1111/j.1530-0277.2006.00118.x 　
Cortical Mechanisms of Segmentation in Visual Sentence Comprehension of Japanese Kana

Oshima, H, J. Hyeonjeong, M. Sugiura, T. Miyamoto, Y. Sassa, N. Ikuta, K. Horie, S. Sato, R. Kawashima

NeuroImage: 12th Annual Meeting of the Organization for Human Brain Mapping. June 11-15, 2006, Florence, Italy.　31　(Supplement 1)　353 W-AW-　2006年
fMRI Evidence for Distinct Neural Substrates for Word Recognition in L1 and L2. 1

Yokoyama,, S, J. Kim, S. Uchida, H. Okamoto, C. Bai, T. Miyamoto, K. Yoshimoto, K. Horie, S. Sato, R. Kawashima

NeuroImage: 12th Annual Meeting of the Organization for Human Brain Mapping. June 11-15, 2006, Florence, Italy.　31　(Supplement 1)　313 W-AW-　2006年
機能的MRIを用いた上顎前突者および下顎前突者における顎運動時の脳血流動態―正常咬合者との比較―

吾妻佳奈, 佐藤亨至, 山本照子, 三浦直樹, 川島隆太

日本矯正歯科学会大会プログラム・抄録集　65th　193　2006年
Influence of task difficulty during meter inspection: An fMRI study 査読有り

Miura Naoki, Takahashi Makoto, Watanabe Jobu, Uchida Shinya, Sato Shigeru, Horie Kaoru, Kitamura Masaharu, Wakabayashi Toshio, Nakamura Katsuki, Kawashima Ryuta

NEUROSCIENCE RESEARCH　55　S263　2006年

ISSN： 0168-0102
アルツハイマー病の予防と進展防止脳機能訓練が有効であるとの立場から (Cognition and Dementia)

川島隆太

Cognition and Dementia　5　(1)　66-69　2006年1月
脳科学の視点から新たな認知リハビリテーションの提案 (精神神経学雑誌)

川島隆太

精神神経学雑誌　107　(12)　1305-1309　2005年12月
アルツハイマー病の非薬物療法 : 学習療法について

川島隆太

臨床神経学 : CLINICAL NEUROLOGY　45　(11)　864-866　2005年11月1日
出版者・発行元：日本神経学会
ISSN： 0009-918X
言語コミュニケーション・第2言語習得の言語認知科学

佐藤滋, JEONG Hyeonjeong, 横山悟, 生田奈穂, 杉浦元亮, 川島隆太

日本音響学会研究発表会講演論文集(CD-ROM)　2005　3-8-11　2005年9月20日

ISSN： 1880-7658
前頭葉の脳機能イメージング (特集前頭前野機能の最前線--基礎から臨床まで)

川島隆太, 泰羅雅登

神経研究の進歩　49　(4)　583-589　2005年8月
出版者・発行元：医学書院
ISSN： 0001-8724
前頭葉の脳機能イメージング (神経研究の進歩)

川島隆太

神経研究の進歩　49　(4)　583-589　2005年8月

DOI： 10.11477/mf.1431100075 　
日本語を学習した中国語母語話者における,日本語構文の理解に関わる脳活動

岡本英行, 白晨, 横山悟, 金情浩, 内田信也, 高橋大厚, 中村渉, 佐藤滋, 堀江薫, 川島隆太

認知神経科学　7　(2)　145-145　2005年7月
出版者・発行元：認知神経科学会
ISSN： 1344-4298
fMRI を用いたデジタル・アナログ計器監視時の脳活動比較

三浦直樹, 渡邉丈夫, 長倉正人, 岩田一樹, 佐藤滋, 堀江薫, 高橋信, 北村正晴, 川島隆太

第２８回日本神経科学大会　2005年7月
The brain activation of syntax comprehension in English-Japanese bilinguals: An fMRI study

Okamoto H, Takahashi D, Sassa Y, Ikuta N, Jeong H, Iwata K, Watanabe J, Akitsuki Y, Miura N, Kawashima R

Second International Workshop on Evolutionary Cognitive Sciences　2005年7月
Brain activation associated with the sentence processing: An fMRI study

Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Riera J, Sato S, Horie K, Matsue Y, Kawashima R

Second International Workshop on Evolutionary Cognitive Sciences　2005年7月
Effects of motion and the body part on activation of the left and right cortical networks for visual self-recognition: An event-related fMRI study. 査読有り

Sugiura M, Sassa Y, Jeong H, Miura N, Iwata K, Akitsuki Y, Horie K, Sato S, Kawashima R

11th International Conference on Functional Mapping of the Human Brain　2005年6月
The role of the Broca's area and left parietal region during processing of a passive sentence in Japanese: An event-related fMRI study. 査読有り

Yokoyama S, Watanabe J, Iwata K, Sassa Y, Akitsuki Y, Miura N, Jeong H, Ikuta N, Okamoto H, Haji T, Usui N, Taira M, Nakamura W, Sato S, Horie K, Kawashima R

11th International Conference on Functional Mapping of the Human Brain　2005年6月
Communicative speech production activates the frontal and anterior cingulate cortices: An fMRI study 査読有り

Sassa Y, Sugiura M, Jeong H, Miura N, Iwata K, Akitsuki Y, Yokoyama S, Watanabe J, Ikuta N, Okamoto H, Uchida S, Riera J, Horie K, Sato S, Kawashima R

11th International Conference on Functional Mapping of the Human Brain　2005年6月
Brain Activation Associated with the Japanese Sentence Comprehension 査読有り

Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Watanabe Y, Sato S, Horie K, Matsue Y, Kawashima R

11th International Conference on Functional Mapping of the Human Brain　2005年6月
Processing of Scrambled Ditransitive Constructions: An fMRI study 査読有り

Kim J, Koizumi M, Kimura N, Watanabe J, Yokoyama S, Ikuta N, Uchida S, Sassa Y, Akitsuki Y, Iwata K, Jeong H, Miura N, Yusa N, Sato S, Horie K, Kawashima R

11th International Conference on Functional Mapping of the Human Brain　2005年6月
Parietal and Prefrontal Activation Associated with Algebraic Calculation: An fMRI study 査読有り

Watanabe J, Miura N, Iwata K, Sassa Y, Namikawa Y, Kawashima R

11th International Conference on Functional Mapping of the Human Brain　2005年6月
Brain activation during inspection for digital and analog meters: An fMRI study 査読有り

Miura N, Watanabe J, Nagakura M, Iwata K, Sato S, Horie K, Takahashi M, Kitamura M, Kawashima R

11th International Conference on Functional Mapping of the Human Brain　2005年6月
前頭前野と音読・計算 (Clinical Neuroscience)

川島隆太

Clinical Neuroscience　23　(6)　623-625　2005年6月
痴呆患者に対するリハビリテーション (内科)

川島隆太

内科　95　(5)　901-904　2005年5月
成人の脳の可塑性と限界 (理学療法ジャーナル)

川島隆太

理学療法ジャーナル　39　(3)　209-213　2005年3月

DOI： 10.11477/mf.1551100046 　
“年齢相応の脳”とは?(第1報)

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 伊藤浩, 井上健太郎, 岡田賢, 小野修一, 川島隆太, 川島隆太, 福田寛

臨床放射線　50　(8)　2005年

ISSN： 0009-9252
「年齢相応の脳」とは?多施設での比較のために

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 福田寛, 川島隆太, 伊藤浩

日本医学放射線学会秋季臨床大会抄録集　41st　2005年

ISSN： 0048-0428
The neural network involved in the processing of give and receive expressions: An fMRI study

Satoru Yokoyama, Noriaki Yusa, Jungho Kim, Hyeonjeong Jeong, Hideyuki Okamoto, Yuko Sassa, Naho Ikuta, Kei Yoshimoto, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

NeuroImage　26　(S1)　49-　2005年
Cortical mechanisms of visual word processing: Comparison of Japanese Kana and Kanji processing during semantic and phonological tasks

Hyeonjeong Jeong, Motoaki Sugiura, Yuko Sassa, Chen Bai, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

NeuroImage　26　(S1)　49-　2005年
医師の診断戦略の導入による脳画像診断精度の向上に関する研究

猪谷達也, 三浦直樹, 高橋信, 川島隆太, 福田寛, 北村正晴

知能システムシンポジウム資料　32nd　27-32　2005年
在宅健常高齢者に対する認知トレーニング介入効果の検討

内田信也, 川島隆太, 寳澤篤, 大森芳, 辻一郎

日本公衆衛生学会総会抄録集　63回　673-673　2004年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
作業記憶課題における刺激提示速度変化に伴う脳活動量の検討

内田信也, 岩田一樹, 渡辺丈夫, 佐々祐子, 三浦直樹, 木之村重男, 佐藤和則, 福田寛, 川島隆太

第27回日本神経科学大会　2004年9月
L1、L2及びL3間の言語学的類似性と関連する神経機構

鄭嫣, 岩田一樹, 渡辺丈夫, 佐々祐子, 生田奈穂, 秋月祐子, 三浦直樹, 岡本英行, 横山悟, Jorge Riera, 土師知己, 臼井信男, 泰羅雅登, 佐藤滋, 川島隆太

第27回日本神経科学大会　2004年9月
fMRIによる文理解に関わる脳活動の研究

生田奈穂, 秋月祐子, 佐々祐子, 渡辺丈夫, 岩田一樹, 三浦直樹, 岡本英行, 佐藤滋, 松江克彦, 川島隆太

第27回日本神経科学大会　2004年9月
代数的計算の脳活動: fMRI研究

渡辺丈夫, 三浦直樹, 岩田一樹, 佐々祐子, 浪川幸彦, 川島隆太

第27回日本神経科学大会　2004年9月
The brain activation of Japanese-English bilingual in sentence comprehension: An fMRI study

Okamoto H, Takahashi D, Sassa Y, Sugiura M, Ikuta N, Iwata K, Watanabe J, Akitsuki Y, Miura N, Matsue K, Kawashima R

The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004年9月
The role of linguistic typology in sentence comprehension by multilinguals: An fMRI study

Jeong H, Iwata K, Watanabe J, Sassa Y, Akitsuki Y, Ikuta N, Okamoto H, Yokoyama S, Miura N, Riera J, Haji T, Usui N, Taira M, Sato S, Kawashima R

The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004年9月
Comprehension of passive sentences in Japanese: An fMRI study.

Yokoyama S, Watanabe J, Iwata K, Sassa Y, Miura N, Jeong H, Ikuta N, Akitsuki Y, Okamoto H, Haji T, Usui N, Taira M, Nakamura W, Sato S, Horie K, Kawashima R

The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004年9月
第一言語・第二言語の理解に関わる脳活動領域の特定(A shared network of cortical regions involved in a first and second language comprehension)

横山悟, 内田信也, 岩田一樹, 金情浩, 岡本英行, Hyeonjeong Jeong, 中村渉, 堀江薫, 佐藤滋, 川島隆太

神経化学　43　(2-3)　572-572　2004年8月
出版者・発行元：日本神経化学会
ISSN： 0037-3796
風景を見分ける PETによる局在 (Clinical Neuroscience)

川島隆太

Clinical Neuroscience　22　(8)　880-881　2004年8月
日英語における受動文理解に関わる脳活動領域の研究 : 日本語母語話者を対象としたfMRI実験より(セッション3)(<特集>人間による言語理解・言語処理)

横山悟, 内田信也, 岩田一樹, キムジョンホ, ジョンヒョンジョン, 岡本英行, 渡辺丈夫, 佐々佑子, 三浦直樹, 秋月祐子, 生田奈穂, ホルヘリエラ, ワンシャオホン, 中村渉, 堀江薫, 吉本啓, 佐藤滋, 川島隆太

電子情報通信学会技術研究報告. TL, 思考と言語　104　(170)　25-30　2004年7月2日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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本研究では、日本語母語話者の脳内において、母語である日本語と第二言語である英語の能動文・受動文処理過程を比較するため、functional MRIによる言語理解実験を行った。日本語と英語の比較の結果からは、共通して活動が見られた領域と、有意な差を示す領域が見られた。本実験の結果より、英語を第二言語として学習している在日の日本語母語話者における日本語・英語の処理は、共通した側面と異なる側面の双方を含んでいる可能性が示唆された。
Changes in the activation pattern during the course of sentence comprehension 査読有り

Ikuta N, Iwata K, Sassa Y, Watanabe J, Akitsuki Y, Miura N, Okamoto H, Riera J, Sato S, Matsue Y, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
Comparison of Accuracy of Clinical Diagnosis by a Support System with Experienced Doctors using Functional Brain Images 査読有り

Takahashi M, Murooka S, Miura N, Matsumoto R, Kitamura M, Kawashima R, Kinomura S, Goto R, Inoue K, Fukuda H, Sato K

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
An fMRI study of scrambling effects on sentence comprehension 査読有り

Kim J, Koizumi M, Ikuta N, Fukumitsu Y, Akitsuki Y, Iwata K, Jeong H, Miura N, Okamoto H, Sassa Y, Watanabe J, Yokoyama S, Yusa N, Sato S, Horie K, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
Brain activation with the change of cognitive load during Paced Visual Serial Addition Task 査読有り

Uchida S, Iwata K, Watanabe J, Sassa Y, Miura N, Fukuda H, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
FMRI Evidence for the Neural Correlates of the Typological Differences among L1, L2, and L3 査読有り

Jeong H, Iwata K, Watanabe J, Sassa Y, Akitsuki Y, Ikuta N, Miura N, Okamoto H, Yokoyama S, Riera J, Haji T, Usui N, Taira M, Horie K, Sato S, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
Parietal and Prefrontal Activation are involved in Algebraic Calculation: An fMRI study. 査読有り

Watanabe J, Miura N, Iwata K, Sassa Y, Namikawa Y, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
The role of the left frontal cortex during judgment of grammatical violation: An fMRI study 査読有り

Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Iwata K, Ikuta N, Miura N, Okamoto H, Sato S, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
An event-related fMRI study of how active and passive sentences are comprehended in Japanese 査読有り

Yokoyama S, Nakamura W, Watanabe J, Sassa Y, Iwata K, Akitsuki Y, Miura N, Jeong H, Ikuta N, Riera J, Okamoto H, Usui N, Taira M, Sato S, Horie K, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
An fMRI study of reading of ancient writings 査読有り

Miura N, Watanabe J, Iwata K, Sassa Y, Riera J, Tsuchiya H, Takahashi M, Kitamura M, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月
脳を知り、脳を育む : 脳機能イメージング研究の最前線

川島隆太

電子情報通信学会技術研究報告. NC, ニューロコンピューティング　104　(99)　29-34　2004年5月21日
出版者・発行元：一般社団法人電子情報通信学会
ISSN： 0913-5685

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脳機能イメージング手法を用いることにより、認知・記憶・意図・運動発現など、さまざまな高次精神活動を行っている時の脳の働きを知ることができる。我々は、この研究の成果を社会へ還元することを目的として、子どもの脳を健全に発育させる方法、高齢者の脳機能低下を予防する方法、痴呆症状を軽減する方法の開発を行っている。こうした脳科学研究から、音読や計算で前頭前野を含む多くの脳領域を活性化することが可能であることを発見し、さらに高齢者介入研究を行うことにより、音読や計算で痴呆症状の改善や、脳機能の向上が図れることを証明した。
痴呆からの脱出学習療法の新展開 (遺伝: 生物の科学)

川島隆太

遺伝: 生物の科学　58　(3)　83-87　2004年5月
味覚の神経機能イメージング (神経研究の進歩)

福田寛, 内田信也, 木之村重男, 川島隆太

神経研究の進歩　48　(2)　285-293　2004年4月

DOI： 10.11477/mf.1431100202 　
顔を見分ける PETによる局在 (Clinical Neuroscience)

川島隆太

Clinical Neuroscience　22　(4)　366-367　2004年4月
動作イメージ課題遂行時の事象関連fMRI

上條憲一, 川島隆太, 山崎敏正, 喜友名朝春, 高木陽子

生体医工学 : 日本エム・イー学会誌　42　(1)　16-21　2004年3月10日
出版者・発行元：社団法人日本生体医工学会
ISSN： 1347-443X

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Through event-related functional magnetic resonance imaging (fMRI), brain activity was mapped in three normal subjects while they imagined grasping a softball with their own hand. During the right-hand-movement imagery task, the dorsolateral prefrontal cortices (BAs 9, 10 and 46), the supplementary motor area (SMA),the pre-motor cortex, the occipital cortices. the anterior cingulate gyrus and the cerebellum were significantly activated. Only in two subjects (YM and TK)did the present imagery task activate the right inferior parietal lobule (IPL) and the left superior temporal gyrus (STG),which are known to be involved in imagery requiring visuospatial information and in silent vocalization of the mimesis. respectively. This finding may exemplify that different imagery strategies activate different brain sites.
SPECT 脳画像診断への自己組織化学習の適用

猪谷達也, 松本怜, 三浦直樹, 高橋信, 川島隆太

第 31 回計測自動制御学会知能システムシンポジウム　2004年3月
受動文の理解における脳内での処理の負荷

横山悟, 渡辺丈夫, 佐々祐子, 岩田一樹, 三浦直樹, 秋月祐子, 鄭嫣, 生田奈穂, ホルヘリエラ, 岡本英行, 土師知己, 臼井信男, 泰羅雅登, 中村渉, 佐藤滋, 堀江薫, 川島隆太

言語処理学会第10回年次大会　2004年3月
まなざし非言語コミュニケーションの脳機能イメージング研究 (脳と神経)

川島隆太

脳と神経　56　(2)　99-106　2004年2月
A functional MRI study of simple arithmetic--a comparison between children and adults.

Kawashima Ryuta, Taira Masato, Okita Katsuo, Inoue Kentaro, Tajima Nobumoto, Yoshida Hajime, Sasaki Takeo, Sugiura Motoaki, Watanabe Job, Fukuda Hiroshi

Brain Res Cogn Brain Res　18　(3)　227-233　2004年

DOI： 10.1016/j.cogbrainres.2003.10.009 　
機能的MRIを用いたメータ監視作業時の脳活動解析

三浦直樹, 渡辺丈夫, 高橋信, 川島隆太, 北村正晴

ヒューマンインタフェースシンポジウム論文集　2004 (CD-ROM)　3134　2004年

ISSN： 1345-0794
SPECT画像による痴呆症の診断システムの研究 (2)医師との診断戦略の比較

室岡澄子, 松本怜, 三浦直樹, 高橋信, 北村正晴, 川島隆太, 福田寛

第37回日本エム・イー学会東北支部大会　2003年11月
SPECT画像による痴呆症の診断システムの研究 (1)機械学習による自動診断

松本怜, 三浦直樹, 高橋信, 北村正晴, 川島隆太, 福田寛

第37回日本エム・イー学会東北支部大会　2003年11月
前頭前野？脳科学から教育・福祉へのメッセージ (医学のあゆみ)

川島隆太

医学のあゆみ　207　565-566　2003年11月
脳を知り、脳を守り、脳を育む (電気学会誌)

川島隆太

電気学会誌　123　(10)　672-676　2003年10月
出版者・発行元： The Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejjournal.123.672 　

ISSN： 1340-5551
視線感知の脳内メカニズム心の理論の解明を目指して (神経心理学)

川島隆太

神経心理学　19　(3)　156-161　2003年9月
近赤外線分光法によるヘモグロビン濃度とfMRIによるBOLD信号との相関

岩田一樹, 杉浦元亮, 渡邊丈夫, 秋月祐子, 佐々祐子, 渡部芳彦, 生田奈穂, 岡本英行, 三浦直樹, 前田泰弘, 松江克彦, 川島隆太

第26回日本神経科学大会　2003年7月
主語、目的語、動詞の処理に関わる脳領域

生田奈穂, 杉浦元亮, 佐々祐子, 渡邊丈夫, 秋月祐子, 岩田一樹, 三浦直樹, 岡本英行, 渡部芳彦, 佐藤滋, 松江克彦, 川島隆太

第26回日本神経科学大会　2003年7月
fMRIを用いた文法処理に伴う左前頭葉領域の脳賦活

佐々祐子, 杉浦元亮, 渡邊丈夫, 秋月祐子, 岩田一樹, 生田奈穂, 三浦直樹, 岡本英行, 佐藤滋, 福田寛, 川島隆太

第26回日本神経科学大会　2003年7月
Brain activation of different grammatical processing in Japanese sentences: An event related fMRI study 査読有り

Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Iwata K, Ikuta N, Miura N, Okamoto H, Sato S, Fukuda H, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月
A method to estimate neuronal dynamic from BOLD signals 査読有り

Riera J, Watanabe J, Iwata K, Miura N, Aubert E, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月
Brain Regions Involved in Appetite: An Event-related fMRI Study 査読有り

Watanabe Y, Sugiura M, Watanabe J, Akitsuki Y, Sassa S, Iwata K, Ikuta N, Miura N, Imaizumi O, Watanabe M, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月
Brain areas involved in understanding of second language in Japanese: An fMRI study. 査読有り

Okamoto H, Takahashi T, Sugiura M, Sassa Y, Ikuta N, Iwata K, Watanabe J, Akitsuki Y, Miura N, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月
Brain Activation Related to Spatial Divided Attention : An fMRI study 査読有り

Iwata K, Sugiura M, Watanabe J, Riera J, Akitsuki Y, Sassa Y, Watanabe Y, Miura N, Ikuta N, Okamoto H, Maeda Y, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月
An fMRI study of reading aloud 査読有り

Miura N, Iwata K, Watanabe J, Sugiura M, Akitsuki Y, Sassa Y, Ikuta N, Okamoto H, Watanabe Y, Riera J, Maeda Y, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月
情動の機能解析 (最新医学)

秋月祐子, 川島隆太

最新医学　58　(3)　448-454　2003年3月
Encoding-related brain activity during deep processing of verbal materials : a PET study

FUJII Toshikatsu, OKUDA Jiro, TSUKIURA Takashi, OHTAKE Hiroya, SUZUKI Maki, KAWASHIMA Ryuta, ITOH Masatoshi, FUKUDA Hiroshi, YAMADORI Atsushi

Neuroscience research : the official journal of the Japan Neuroscience Society　44　(4)　429-438　2002年12月1日

ISSN： 0168-0102
バーチャルリアリティーなどの視覚刺激に対する血管運動反応のカオス解析 (血管医学)

山家智之, 南家俊介, 仁田新一, 田林光一, 川島隆太, 福田寛, 吉澤誠

血管医学　3　(5)　529-535　2002年10月
【知・情・意のバランス】「知・情・意」の統合を育む子どもの脳を育てる教育 (教育と医学)

川島隆太

教育と医学　50　(10)　882-887　2002年10月
前頭前野機能発達・維持・増進システム開発研究 : (その1)高齢者の脳機能、知的機能、日常生活態度に与える読み書き計算学習の影響

沖田克夫, 佐々木丈夫, 前山克次郎, 山崎律美, 川島隆太, 田島信元, 吉田甫, 泰羅雅登

日本教育心理学会総会発表論文集　44　(44)　27-27　2002年8月9日
出版者・発行元：日本教育心理学会
DOI： 10.20587/pamjaep.44.0_27 　
Correlation between brain activity and personality scores reflects difference in spontaneous response to external stimuli

M Sugiura, R Kawashima

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY　45　(1-2)　38-38　2002年7月

ISSN： 0167-8760
A principal component analysis on whole brain shape utilizing a spherical harmonics expansion 査読有り

Shida K, Hakoda N, Miura N, Kawashima R, Shimizu T, Fukuda H, Kawazoe Y

8th International Conference on Functional Mapping of the Human Brain　2002年6月
Morphological analysis of MR brain images by spherical harmonics 査読有り

Hakoda N, Miura N, Shida K, Kawashima R, Fukuda H, Kawazoe Y, Shimizu T

8th International Conference on Functional Mapping of the Human Brain　2002年6月
Automatic Brain Tissue Segmentation Method from MRI T1-weighted Data 査読有り

Miura N, Taneda A, Shida K, Kawashima R, Fukuda H, Kawazoe Y, Shimizu T

8th International Conference on Functional Mapping of the Human Brain　2002年6月
自己の顔認知のイメージング研究 (脳の科学)

杉浦元亮, 川島隆太

脳の科学　24　(4)　378-380　2002年4月
機械学習による脳機能画像からの診断知識の獲得

荒川和樹, 酒井大輔, 高橋信, 北村正晴, 福田寛, 川島隆太, 栗田主一, 武田篤

知能システムシンポジウム資料　29　235-240　2002年3月28日
3次元頭部MRI画像脳領域自動抽出法の提案とその性能評価

三浦直樹, 種田晃人, 志田和人, 川島隆太, 川添良幸, 福田寛, 清水俊夫

情報処理学会全国大会講演論文集　64th　(2)　2.243-2.244　2002年3月12日
球面調和関数展開による脳表面形状特性解析

箱田直子, 三浦直樹, 志田和人, 川島隆太, 川添良幸, 福田寛, 清水俊夫

情報処理学会全国大会講演論文集　64th　(4)　4.313-4.314　2002年3月12日
動作イメージ課題における脳内活動のfunctional MRIによる観察 (臨床脳波)

上条憲一, 川島隆太, 山崎敏正

臨床脳波　44　(3)　148-153　2002年3月
Changes in regional cerebral blood flow abnormalities in late-life depression following response to electroconvulsive therapy

AWATA SHUICHI, KONNO MICHIKO, KAWASHIMA RYUTA, SUZUKI KAZUMASA, SATO TOSHIMITSU, MATSUOKA HIRO, FUKUDA HIROSHI, SATO MITSUMOTO

Psychiatry and clinical neurosciences　56　(1)　31-40　2002年2月1日

ISSN： 1323-1316
脳血流SPECTカウントは脳灰白質密度を反映するか?

木之村重男, 後藤了以, 井上健太郎, 中川学, 瀧靖之, 佐藤和則, 川島隆太, 福田寛

核医学　39　(3)　2002年

ISSN： 0022-7854
臨床用MR画像による脳組織容積計測

木之村重男, 小野修一, 後藤了以, 井上健太郎, 中川学, 杉浦元亮, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会雑誌　62　(6)　2002年

ISSN： 0048-0428
Time-Dependent Contribution of the Hippocampal Complex during Remembering the Past: A PET Study

Tsukiura T., Fujii T., Okuda J., Ohtake H., Kawashima R., Itoh M., Fukuda H., Yamadori A.

CYRIC annual report　2002　121-130　2002年
出版者・発行元： Cyclotron and Radioisotope Center, Tohoku University
脳血流パターンの複雑性解析

山家智之, 久保豊, 南家俊介, 吉澤誠, 川島隆太, 杉浦元亮, 田林晄一, 田中明, 竹田宏, 仁田

Therapeutic Research　23　(9)　1884-1887　2002年
Functional imaging studies of attention

Ryuta Kawashima

Clinical Neurology　41　(12)　1137-1139　2001年12月1日

ISSN： 0009-918X
報酬に対する脳活動変化の文脈依存性 event-related fMRI

秋月祐子, 杉浦元亮, 渡辺丈夫, 山下圭一, 粟田主一, 松岡洋夫, 前田泰弘, 松江克彦, 福田寛, 川島隆太

神経化学　40　(2-3)　402-402　2001年9月
出版者・発行元：日本神経化学会
ISSN： 0037-3796
functional MRIによる運動野領域の機能マッピング (脳の科学)

川島隆太, 渡辺丈夫, 杉浦元亮, 佐藤優子, 前田泰弘, 松江克彦

脳の科学　23　(9)　761-765　2001年9月
Normal aging and sexual dimorphism of Japanese brain

R Goto, R Kawashima, A Zijdenbos, P Neelin, J Lerch, K Sato, S Ono, M Nakagawa, Y Taki, M Sugiura, J Watanabe, H Fukuda, AC Evans

NEUROIMAGE　13　(6)　S794-S794　2001年6月

ISSN： 1053-8119
Different functional roles of human frontal and parietal cortices in memory-guided saccade: An event-related fMRI study

M Sugiura, R Kawashima, J Watanabe, Y Sato, Y Maeda, Y Matsue, K Sato, A Harada, H Fukuda

NEUROIMAGE　13　(6)　S365-S365　2001年6月

ISSN： 1053-8119
Functional MR imaging of cue-invariant shape perception

K Nakamura, R Kawashima, A Hanazawa, Y Sato, M Sugiura, J Watanabe, K Sato, Y Maeda, Y Matsue, H Fukuda

NEUROIMAGE　13　(6)　S917-S917　2001年6月

ISSN： 1053-8119
fMRIからみた右半球症状 (臨床神経科学)

杉浦元亮, 川島隆太, 福田寛

臨床神経科学　19　(4)　434-436　2001年4月
通信・放送機構青葉脳画像リサーチセンターの紹介 : 統合的先端脳画像情報通信ネットワークに関する研究開発

鈴木一正, 志田和人, 早川友恵, 川添良幸, 大槻昌夫, 川島隆太, 福田寛

画像電子学会誌　30　(2)　182-184　2001年3月25日
出版者・発行元：画像電子学会
ISSN： 0285-9831
人の性格と脳活動の関係

杉浦元亮, 川島隆太, 中川学, 岡田賢, 佐藤多智雄, 後藤了以, 佐藤和則, 小野修一, 福田寛

加齢医学研究所雑誌　52　(1/2)　2001年

ISSN： 1340-3397
パーキンソン病におけるInsular CortexとSupple mentary Motor Area(SMA)の脳血流低下

菊池昭夫, 武田篤, 金原禎子, 糸山泰人, 中川学, 川島隆太, 福田寛, 沖田直, 高瀬貞夫

臨床神経学　40　(12)　1396-1396　2000年12月
出版者・発行元： (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Contribution of the rostral part of the left temporal lobe to retrieving people's names: A functional MRI study

Takashi Tsukiura, Takashi Tsukiura, Toshikatsu Fujii, Jiro Okuda, Jiro Okuda, Michio Tabuchi, Kengo Kurata, Kyoko Suzuki, Atsushi Umetsu, Ryuta Kawashima, Isao Yanagawa, Tatsuo Nagasaka, Atsushi Yamadori, Shoki Takahashi, Hiroshi Fukuda

NeuroImage　11　2000年12月1日

ISSN： 1053-8119
Functional MRIによる手指複雑運動(Luria's fist-edge-palm test)施行時の脳賦活部位の検討

梅津篤司, 高橋昭喜, 日向野修一, 村田隆紀, 奥田次郎, 月浦崇, 藤井利勝, 山鳥重, 杉浦元亮, 井上健太郎, 川島隆太, 福田寛

臨床放射線　45　(12)　1515-1523　2000年11月
出版者・発行元：金原出版(株)
ISSN： 0009-9252
Functional roles of the dorsal premoto cortex in sensory-triggered finger movement 査読有り

Sugiura M, Kawashima R, Takahashi T, Xiao R, Tsukiura T, Fukuda H, Iijima T

The 30th Annual Meeting of Society for Neuroscience, New Orleans, USA　2000年11月
脳イメージングによる認知神経心理機能の研究

川島隆太

失語症研究 : 日本失語症研究会誌 = Higher brain function research　20　(3)　244-250　2000年9月30日

ISSN： 0285-9513
Construction of a Large Scale 3D Image Database of Human Brain

Kazuhito Shida, Yoshiyuki Kawazoe, Kazuya Kumekawa, Ryuta Kawashima, Masao Otsuki, Hiroshi Fukuda

情報知識学会誌　10　(2)　2-11　2000年7月
Different response patterns of the human dorsal premotor cortex during sensory triggered movement with different sensory cues 査読有り

Sugiura M, Kawashima R, Takahashi T, Xiao R, Iijima T, Tsukiura T, Fukuda H

6th Annual Conference of Organization for Human Brain Mapping, San Antonio, USA　2000年6月
Fast reaction to different sensory modalities activates common fields in the motor areas, but the anterior cingulate cortex is involved in the speed of reaction

E Naito, S Kinomura, S Geyer, R Kawashima, PE Roland, K Zilles

JOURNAL OF NEUROPHYSIOLOGY　83　(3)　1701-1709　2000年3月

ISSN： 0022-3077
Human cerebellum plays an important role in memory-timed finger movement: An fMRI study

Ryuta Kawashima, Jiro Okuda, Atsushi Umetsu, Motoaki Sugiura, Kentaro Inoue, Kyoko Suzuki, Michio Tabuchi, Takashi Tsukiura, Singh L. Narayan, Tatsuo Nagasaka, Isao Yanagawa, Toshikatsu Fujii, Shoki Takahashi, Hiroshi Fukuda, Atsushi Yamadori

Journal of Neurophysiology　83　1079-1087　2000年2月23日

ISSN： 0022-3077
人の名前の長期記憶に関与する大脳領域

杉浦元亮, 川島隆太, 渡辺丈夫, 佐藤和則, 福田寛, 佐藤優子, 前田泰弘, 松江克彦

日本神経科学大会プログラム・抄録集　23rd　2000年

ISSN： 1347-8583
Passive and active recognition of one's own face

M Sugiura, R Kawashima, K Nakamura, E Okada, T Kato, A Nakamura, K Hatano, K Itoh, S Kojima, H Fukuda

NEUROIMAGE　11　(1)　36-48　2000年1月

DOI： 10.1006/nimg.1999.0519 　

ISSN： 1053-8119
Recall of Embedded Words from a Story: a PET Study

Ohtake H., Fujii T., Okuda J., Tsukiura T., Kawashima R., Itoh M., Fukuda H., Yamadori A.

CYRIC annual report　2000　135-139　2000年
出版者・発行元： Cyclotron and Radioisotope Center, Tohoku University
Functional mapping of human brain in olfactory processing: a PET study.

Qureshy A, Kawashima R, Imran M B, Sugiura M, Goto R, Okada K, Inoue K, Itoh M, Schormann T, Zilles K, Fukuda H

J Neurophysiol　84　(3)　1656-1666　2000年
顔認知に関するH₂¹⁵O‐PET activation study

杉浦元亮, 川島隆太, 福田寛, 中村克樹, 佐藤暢哉, 小嶋祥三, 加藤隆司, 中村昭範, 伊藤健吾

核医学　36　(9)　1036　1999年12月20日

ISSN： 0022-7854
パーキンソン病における脳血流SPECTの客観的検討

菊池昭夫, 武田篤, 金原禎子, 糸山泰人, 中川学, 川島隆太, 福田寛, 沖田直, 高瀬貞夫

臨床神経学　39　(12)　1369-1369　1999年12月
出版者・発行元： (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Activations of prefronto-parietal and temporal cortices during encoding and retrieval of visually presented words: A single-trial based fMRI Study

Hiroshi Fukuda, Okuda Jiro, Okuda Jiro, Michio Tabuchi, Ryuta Kawashima, Atsushi Umetsu, Kyoko Suzuki, Takashi Tsukiura, Motoaki Sugiura, Kentaro Inoue, Isao Yanagawa, Tatsuo Nagasaka, Singh Laxmi Narayan, Singh Laxmi Narayan, Toshikatsu Fujii, Toshikatsu Fujii, Atsushi Yamadori, Shoki Takahashi

NeuroImage　9　1999年12月1日

ISSN： 1053-8119
ポジトロンCTによる脳賦活試験

川島隆太

核医学　36　(6)　536-536　1999年8月20日

ISSN： 0022-7854
運動と脳血流動態 (特集リハビリテーシヨン医学の基礎--運動生理学)

川島隆太, 福田寛

総合リハビリテ-ション　27　(8)　713-717　1999年8月
出版者・発行元：医学書院
ISSN： 0386-9822
顔の認知に関わる脳領野の個人差 intra‐subject PET activation study

杉浦元亮, 川島隆太, 中村克樹, 佐藤暢哉, 加藤隆司, 中村昭則, SCHORMANN T, ZILLES K, 福田寛

日本神経科学大会プログラム・抄録集　22nd　158　1999年7月6日

ISSN： 1347-8583
Brain activation during generation and recall of word evaluated with functional MRI 査読有り

シン・ナラヤン, 奥田次郎, 鈴木匡子, 田渕実治郎, 月浦崇, 梅津篤司, 梁川功, 永坂竜男, 杉浦元亮, 井上健太郎, 川島隆太, 福田寛, 高橋昭喜, 山鳥重

第22回日本神経科学大会，大阪　1999年7月
The neural basis of written language processing evaluated with functional magnetic resonance imaging 査読有り

田渕実治郎, 奥田次郎, 月浦崇, 鈴木匡子, シン・ナラヤン, 藤井俊勝, 梅津篤司, 梁川功, 永坂竜男, 川島隆太, 杉浦元亮, 井上健太郎, 高橋昭喜, 福田寛, 山鳥重

第22回日本神経科学大会，大阪　1999年7月
A positron emission tomography study of self-paced finger movements at different frequencies.

Kawashima R, Inoue K, Sugiura M, Okada K, Ogawa A, Fukuda H

Neuroscience　92　(1)　107-112　1999年

DOI： 10.1016/S0306-4522(98)00744-1 　
Three Dimensions in the State of Memory and Emotion Concerned with a Person: Factor Analysis Using Subject's Self Evaluation and PET

Sugiura M., Kawashima R., Gotoh R., Okada K., Watanabe J., Satoh K., Yamaguchi K., Itoh M., Schormann T., Fukuda H.

CYRIC annual report　1999　177-181　1999年
出版者・発行元： Cyclotron and Radioisotope Center, Tohoku University

詳細を見る詳細を閉じる

開始ページ、終了ページ: 冊子体のページ付け
A comparison of Tc-99m HMPAO brain SPECT images of young and aged normal individuals

GOTO Ryoi, KAWASHIMA Ryuta, ITO Hiroshi, KOYAMA Masamichi, SATO Kazunori, ONO Shuichi, YOSHIOKA Seiro, FUKUDA Hiroshi

Annals of nuclear medicine　12　(6)　333-339　1998年12月1日

ISSN： 0914-7187
無痙攣電撃療法によるうつ病脳SPECT所見の変化

川島隆太, 福田寛, 粟田主一, 金野倫子, 佐藤光源

核医学　35　(9)　956-956　1998年11月
出版者・発行元： (一社)日本核医学会
ISSN： 0022-7854
ポジトロンCTによる聴覚注意機構の研究

川島隆太, 後藤了以, 福田寛

日本音響学会研究発表会講演論文集　1998　(2)　405-406　1998年9月1日

ISSN： 1340-3168
鬱病患者の無痙攣電撃療法に伴う脳血流変化 99mTc-HMPAO-SPECT study

杉浦元亮, 川島隆太, 木之村重男, 福田寛, 金野倫子, 粟田主一, 佐藤光源

核医学　35　(7)　543-543　1998年8月
出版者・発行元： (一社)日本核医学会
ISSN： 0022-7854
Regional cerebral blood flow abnormalities in late-life depression : Relation to refractoriness and chronification

AWATA SHUICHI, ITO HIROSHI, KONNO MICHIKO, ONO SHUICHI, KAWASHIMA RYUTA, FUKUDA HIROSHI, SATO MITSUMOTO

Psychiatry and clinical neurosciences　52　(1)　97-105　1998年2月1日

ISSN： 1323-1316
PETによるヒトの手の運動機能マップ (特集手の運動の制御と学習)

川島隆太, 井上健太郎, 松村道一

神経研究の進歩　42　(1)　139-145　1998年2月
出版者・発行元：医学書院
ISSN： 0001-8724
大規模ヒト脳画像データベースの構築

志田和人, 川添良幸, 粂川一也, 川島隆太, 大槻昌夫, 福田寛

信学ソ大, 1998　19-19　1998年
出版者・発行元：一般社団法人電子情報通信学会
認知神経科学と非侵襲性技法の進歩 (特集ニュ-ロサイエンス最前線--脳と心のメカニズムを探る)

川島隆太, 福田寛

数理科学　36　(1)　55-59　1998年1月
出版者・発行元：サイエンス社
ISSN： 0386-2240
Olfactory Stimulus Processing by Human Brain-A Functional Study

Qureshy A., Kawashima R., Imran M. B., Sugiura M., Goto R., Okada K., Inoue K., Itoh M., Fukuda H.

CYRIC annual report　1998　155-160　1998年
出版者・発行元： Cyclotron and Radioisotope Center, Tohoku University

詳細を見る詳細を閉じる

開始ページ、終了ページ: 冊子体のページ付け
「自己の顔」の内部表象: PET activation study 査読有り

杉浦元亮, 川島隆太, 中村克樹, 岡田賢, 加藤隆司, 中村昭範, 旗野健太郎, 伊藤健吾, 小嶋I三, 福田寛

第21回神経科学第41回神経化学合同大会（1998年9月, 東京). プログラム／抄録集 p. 218.　1998年
パラ言語情報と音声の知覚・理解音声の総合的理解を目指して声による話者と感情の認知機構

今泉敏, 森浩一, 桐谷滋, 川島隆太, 杉浦元亮, 伊藤健吾, 加藤隆司, 小嶋祥三, 中村克樹

日本音響学会研究発表会講演論文集　1997　(2)　391-392　1997年9月

ISSN： 1340-3168
脳科学シリ-ズ-14-ポジトロンCTによる記憶のメカニズムの解明

川島隆太, 福田寛

臨床科学　33　(8)　1008-1012　1997年8月
出版者・発行元：エ-スア-ト
ISSN： 0385-0323
A method for the quantification of benzodiazepine receptors by using ^<123>I-iomazenil and SPECT with one scan and one blood sampling

ITO Hiroshi, KAWASHIMA Ryuta, KOYAMA Masamichi, GOTO Ryoui, SATO Kazunori, ONO Shuichi, FUKUDA Hiroshi

Annals of nuclear medicine　11　(2)　101-108　1997年5月

ISSN： 0914-7187
Cerebral perfusion changes in traumatic diffuse brain injury; IMP SPECT studies

ITO Hiroshi, ISHII Kiyoshi, ONUMA Takehide, KAWASHIMA Ryuta, FUKUDA Hiroshi

Annals of nuclear medicine　11　(2)　167-172　1997年5月

ISSN： 0914-7187
Functions of Parahippocampal Regions and Frontal Lobes in Alternative Judgment of Novelty and Familiarity for Auditorily Presented Words

Motooka N., Okuda J., Fujii T., Yamadori A., Tsukiura T., Kawashima R., Fukatsu R., Suzuki K., Ito M., Fukuda H.

CYRIC annual report　1997　132-137　1997年
出版者・発行元： Cyclotron and Radioisotope Center, Tohoku University

詳細を見る詳細を閉じる

開始ページ、終了ページ: 冊子体のページ付け
脳血流SPECTの客観的評価法の開発

川島隆太, 佐藤和則, 伊藤浩, 小山真道, 後藤了以, 吉岡清郎, 小野修一, 佐藤多智雄, 福田寛

核医学　33　(12)　1359-1362　1996年12月20日

ISSN： 0022-7854
運動を遂行させる脳への血液循環 (特集運動中の血液需給システム)

川島隆太, 岡田賢, 福田寛

体育の科学　46　(10)　801-805　1996年10月
出版者・発行元：杏林書院
ISSN： 0039-8985
ポジトロンCTによる随意運動の機能解剖 (特集巧みな動作の脳機構)

川島隆太, 福田寛

体育の科学　46　(6)　472-476　1996年6月
出版者・発行元：杏林書院
ISSN： 0039-8985
集中的医用画像情報処理システム

福田寛, 川島隆太, 佐藤和則

画像電子学会誌　25　(1)　89-91　1996年2月25日
出版者・発行元：画像電子学会
ISSN： 0285-9831
IMP-ARG法による局所脳血流量の正常値 : マイクロスフェア法との比較

伊藤浩, 石井清, 木下俊文, 小山真道, 川島隆太, 小野修一, 福田寛

核医学　33　(2)　175-178　1996年2月20日

ISSN： 0022-7854
^<99m>Tc-ECD SPECTによる正常脳血流像の作成 : 解剖学的標準化による評価

川島隆太, 小山真道, 伊藤浩, 吉岡清郎, 佐藤和則, 小野修一, 後藤了以, 佐藤多智雄, 福田寛

核医学　33　(1)　69-72　1996年1月20日

ISSN： 0022-7854
A PET Study of Memory for Future Plan

Okuda J., Fujii T., Yamadori A., Kawashima R., Fukatsu R., Suzuki K., Tsukiura T., Motooka N., Ito M., Fukuda H.

CYRIC annual report　1996　172-175　1996年
出版者・発行元： Cyclotron and Radioisotope Center, Tohoku University

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開始ページ、終了ページ: 冊子体のページ付け
Error analysis of autoradiography method for measurement of cerebral blood flow by ^<123>I-IMP brain SPECT: A comparison study with table look-up method and microsphere model method

ITO Hiroshi, ISHII Kiyoshi, ATSUMI Hiroto, INUKAI Yoshimasa, ABE Shigeto, SATO Masami, KINOSHITA Toshifumi, KAWASHIMA Ryuta, ONO Shuichi, FUKUDA Hiroshi

Annals of nuclear medicine　9　(4)　185-190　1995年11月1日

ISSN： 0914-7187
PETによる脳機能マッピング (脳機能イメ-ジング<特集>)

川島隆太, 福田寛

医学のあゆみ　175　(3)　p185-188　1995年10月21日
出版者・発行元：医歯薬出版
ISSN： 0039-2359
^<99m>Tc-HMPAO SPECTによる正常平均脳血流像の作成 : 解剖学的標準化による評価

小山真道, 川島隆太, 伊藤浩, 小野修一, 佐藤和則, 後藤了以, 赤井澤隆, 吉岡清郎, 佐藤多智雄, 福田寛

核医学　32　(9)　969-977　1995年9月20日

ISSN： 0022-7854
脳

川島隆太, 福田寛

核医学　32　(8)　731-731　1995年8月20日

ISSN： 0022-7854
新しい核医学用三次元的頭部固定装置の作製と評価

後藤了以, 川島隆太, 吉岡清郎, 小野修一, 伊藤浩, 佐藤和則, 赤井沢隆, 小山真道, 福田寛

核医学　32　(7)　689-694　1995年7月20日

ISSN： 0022-7854
FUNCTIONAL-ANATOMY OF TASTE PERCEPTION IN THE HUMAN BRAIN STUDIED WITH POSITRON EMISSION TOMOGRAPHY

S KINOMURA, R KAWASHIMA, K YAMADA, S ONO, M ITOH, S YOSHIOKA, T YAMAGUCHI, H MATSUI, H MIYAZAWA, H ITOH, R GOTO, T FUJIWARA, K SATOH, H FUKUDA

BRAIN RESEARCH　659　(1-2)　263-266　1994年10月

ISSN： 0006-8993
Functional Organization of the Human Primary Motor Area: An Update on Current Concepts

Ryuta Kawashima, Hiroshi Fukuda

Reviews in the Neurosciences　5　(4)　347-354　1994年

DOI： 10.1515/REVNEURO.1994.5.4.347 　

ISSN： 2191-0200 0334-1763
Handedness and Motor Function - CBF Study -

Kawashima R., Yamada K., Kinomura S., Yamaguchi T., Matsui H., Fukuda H.

CYRIC annual report　1990　215-217　1990年
出版者・発行元： Cyclotron and Radioisotope Center, Tohoku University

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開始ページ、終了ページ: 冊子体のページ付け

︎全件表示 ︎最初の5件までを表示

書籍等出版物 5

機能的脳イメージング法．言語コミュニケーション障害の新しい視点と介入理論（

佐々祐子, 生田奈穂, 鄭嫣婷, 川島隆太

医学書院　2005年9月15日
脳の形態と機能

福田寛 ed, 岩田一樹, ホルヘ・リエラ, 川島隆太

新興医学出版社　2005年6月28日
対照言語学の新展開

佐藤滋, 堀江薫, 中村渉 ed, 佐々祐子, 佐藤滋, 川島隆太

ひつじ書房　2004年8月9日
医食同源「痴呆・ボケ」

川島隆太

実業之日本社　2004年6月9日
脳の高次機能

丹治順, 吉澤修治, 川島隆太

朝倉書店　2001年4月6日

講演・口頭発表等 267

脳の働きと朝ごはん

川島隆太

日本食育学会　2007年12月8日
脳を知り、脳を鍛える

川島隆太

第46回日本臨床細胞学会秋期大会　2007年11月30日
外国語学習者の言語能力評価における脳機能データの応用

横山悟, 吉本啓, 川島隆太

思考と言語研究会　2007年11月16日
認知症改善・予防とケア

川島隆太

第15回日本介護福祉学会大会　2007年10月6日
脳を知り、脳を鍛える

川島隆太

日本歯科技工学会第29回学術大会　2007年9月22日
Brain activities related to inferring familiar and unfamiliar persons’ decision-makings: An fMRI study

Tachibana Y, Sugiura M, Sassa Y, Jeong H, Wakusawa K, Fukushima A, Kawashima R

第30回日本神経科学会大会　2007年9月10日
自己肯定に関する脳機能イメージング研究

福島愛, 杉浦元亮, 三浦直樹, 内田信也, 関口敦, 堀江薫, 佐藤滋, 川島隆太

第30回日本神経科学会大会　2007年9月10日
内省未来志向のコーピングスタイルは右側頭領域の活動が関与している

Sekiguchi A, Sugiura M, Yokoyama S, Kanbara T, Ikuta N, Sato S, Horie K, Kawashima R

第30回日本神経科学会大会　2007年9月10日
A longitudinal fMRI study of neural plasticity in the second language lexical processing

Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

第30回日本神経科学会大会　2007年9月10日
Reanalysis in Japanese sentence comprehension: An fMRI study

Ikuta N, Yokoyama S, Jeong H, Sugiura M, Horie K, Sato S, Kawashima R

第30回日本神経科学会大会　2007年9月10日
Prevention of senile dementia by brain training: a message from neuroimaging research 国際会議

Kawashima R

The third World Ageing & Generations Congress　2007年9月6日
日本語の脳内における統語処理と語彙意味処理のfMRI研究

神原利宗, 横山悟, 生田奈穂, 鄭嫣婷, 高橋慶, 関口敦, 宮本正夫, 高橋大厚, 小泉政利, 吉本啓, 堀江薫, 佐藤滋, 川島隆太

日本認知科学会第24回大　2007年9月3日
専門職としての脳の鍛え方―創造的思考を育てるために

川島隆太

第38回日本看護学会　2007年8月9日
Working memory system as a sentence processor in the human brain 国際会議

Yokoyama S, Takahashi K, Kambara T, Miyamoto T, Yoshimoto K, Kawashima R

An International Workshop on Mental Architecture for Processing and Learning of Language　2007年7月14日
脳を知り，脳を鍛える

川島隆太

第20回日本顎関節学会総会　2007年7月13日
自己と他者を分ける脳活動と自我同一性との関係

立花良之, 杉浦元亮, 佐々裕子, 横山悟, Hyeonjeong Jeong, 涌澤圭介, 福島愛, 川島隆太

第29回日本生物学的精神医学会大会　2007年7月11日
Neural plasticity for second language learning in the brain: A longitudinal fMRI study

Yokoyama S, Kim J, Uchida S, Bai C, Okamoto H, Yusa N, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

The Japanese Society for Language Sciences' Ninth Annual International Conference　2007年7月7日
fMRI evidence for distinct neural mechanisms between the lexical and sentence processing: the case of the processing of passives 国際会議

Yokoyama S, Yoshimoto K, Miyamoto T, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月28日
Cortical networks sensitive to the difference in motion and appearance of humanoid robot and human: an fMRI study 国際会議

Miura N, Sugiura M, Takahashi M, Sassa Y, Moridaira T, Miyamoto A, Kuroki Y, Sato S, Horie K, Nakamura K, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
Syntactic and Lexical-semantic Processing during Sentence Comprehension in Head-final Language 国際会議

Kambara T, Yokoyama S, Ikuta N, Jeong H, Takahashi K, Sekiguchi A, Miyamoto T, Takahashi D, Yoshimoto K, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
Brain activities, which related to ego identity and social distinction between self and others 国際会議

Tachibana Y, Sugiura M, Sassa Y, Jeong H, Wakusawa K, Fukushima A, Sato S, Horie K, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
Domain-specific person-representations in posterior cortices: an fMRI study on famous-name recognition 国際会議

Sugiura M, Sassa Y, Wakusawa K, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
Brain activation associated with reanalysis in sentence comprehension: An fMRI study 国際会議

Ikuta N, Yokoyama S, Jeong H, Sugiura M, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
Cortical mechanism of ideal self – an fMRI study 国際会議

Fukushima A, Miura N, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
The neural mechanisms of the second language comprehension 国際会議

Oshima R, Ikuta N, Sugiura M, Yokoyama S, Jeong H, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
The difference of the brain activation in the left prefrontal regions in language proficiency 国際会議

Oshima R, Ikuta N, Sugiura M, Yokoyama S, Jeong H, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
Activity in the right temporal pole is associated with the self-prospective direction in stress coping patterns 国際会議

Sekiguchi A, Sugiura M, Yokoyama S, Kanbara T, Ikuta N, Sato S, Horie K, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
Development of L2 lexical processing: A longitudinal fMRI study 国際会議

Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

13th Annual Meeting of the Organization for Human Brain Mapping　2007年6月10日
脳科学からみた、早寝・早起き・朝ごはんの重要性

川島隆太

平成19年度第一回食育推進交流シンポジウム　2007年6月5日
脳を知り、脳を鍛える

川島隆太

第48回日本心身医学会　2007年5月24日
食と脳科学

川島隆太

第50回日本糖尿病学会年次学術集会　2007年5月24日
Thematic difficulty causes processing cost for sentence comprehension 国際会議

Yokoyama S, Koizumi M, Kim J, Yusa N, Yoshimoto K, Kawashima R

2nd European cognitive science conference　2007年5月23日
Linearizability of neuro-vascular coupling resulting from low-frequency intermediate-duration stimuli 国際会議

Rasmussen T, Lauritzen M, Kawashima R

The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function and The 8th International Conference on Quantification of Brain Function with PET　2007年5月20日
脳を知り、脳を鍛え、認知症を予防する

川島隆太

第10回国際福祉健康産業展覧会　2007年5月18日
脳科学が教える脳の鍛え方

川島隆太

第46回日本生体医工学会大会　2007年4月25日
Brain activation during second language processing: A cross-linguistic approach 国際会議

Jeong H, Sugiura M, Sato S, Kawashima R

American Association of Applied Linguistics, Costa Mesa　2007年4月22日
脳科学から新産業を創製する

川島隆太

第63回日本放射線技術学会　2007年4月13日
有名人の性格と知識はそれぞれ左側頭頭頂接合部と中側頭回で表象されている

杉浦元亮, 佐々祐子, 涌澤圭介, 堀江薫, 佐藤滋, 川島隆太

第9回日本ヒト脳機能マッピング学会大会　2007年3月16日
脳を知り、脳を鍛える

川島隆太

第41回日本成人病学会　2007年1月13日
fMRIによるかき混ぜ文の処理に関する研究？刺激呈示モダリティに依存しない脳活動の特定

生田奈穂, 金情浩, 小泉政利, 佐藤滋, 堀江薫, 川島隆太

日本言語学会第133回大会　2006年11月18日
脳を知り、脳を育む

川島隆太

第9回日本腎不全看護学会　2006年11月11日
脳を鍛える

川島隆太

第17回全国介護施設老人保健施設大会　2006年11月8日
脳の健康

川島隆太

日本健康科学学会第22回学術大会　2006年10月27日
Context dependency of self concept during face recognition: fMRI evidence 国際会議

Sugiura M, Sassa Y, Joeng H, Wakusawa K, Horie K, Sato S, Kawashima R

36th Annual Meeting of Society for Neuroscience　2006年10月14日
Concurrent EEG correlates of event-related and spontaneous fMRI: implications for neural basis of functional imaging 国際会議

Wan X, Riera J, Kawashima R

28th International Congress of Clinical Neurophysiology,　2006年9月10日
Neural mechanisms for visual word recognition in the second language 国際会議

Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

CBL Seminar　2006年8月8日
空間フィルターを用いたEEG/MEGソースにおける空間分解能の最適化

Wan Xiaohong, 関口敦, 横山悟, Riera Jorge, 川島隆太

第29回日本神経科学大会　2006年7月19日
計器監視課題における難易度の影響：fMRIによる研究

三浦直樹, 高橋信, 渡邉丈夫, 内田信也, 佐藤滋, 堀江薫, 北村正晴, 若林利男, 中村克樹, 川島隆太

第29回日本神経科学大会　2006年7月19日
第一言語と第二言語の単語理解は異なる脳内基盤で処理される

横山悟, キムジュンホ, 内田信也, 岡本英行, バイチェン, 宮本正夫, 吉本啓, 堀江薫, 佐藤滋, 川島隆太

第29回日本神経科学大会　2006年7月19日
言語関連領野の神経線維連絡：機能的MRIと拡散テンソル画像による検討

内田信也, 三浦直樹, 渡邉丈夫, 木之村重男, 佐藤和則, 瀧靖之, 井上健太郎, 後藤了以, 岡田賢, 福島愛, 堀江薫, 佐藤滋, 中村克樹, 福田寛, 川島隆太

第29回日本神経科学大会　2006年7月19日
外国語語彙の学習と想起の記憶転移に関わる神経機構

Hyeonjeong Jeong, 杉浦元亮, 佐々裕子, 涌澤圭介, 堀江薫, 佐藤滋, 川島隆太

第29回日本神経科学大会　2006年7月19日
危険／安全な状況下における脳活動の個人差解析：機能的MRIによる研究

関口敦, 生田奈穂, 杉浦元亮, 岡本英行, 佐藤滋, 堀江薫, 川島隆太

第29回日本神経科学大会　2006年7月19日
新しい知識を獲得するときの興味に関する脳機能イメージング研究

福島愛, 三浦直樹, 内田信也, 杉浦元亮, 堀江薫, 佐藤滋, 川島隆太

第29回日本神経科学大会　2006年7月19日
危険認知の大脳機構

杉浦元亮, 関口敦, 涌澤圭介, 佐々祐子, ジョンヒョンジョン, 堀江薫, 佐藤滋, 川島隆太

第29回日本神経科学大会　2006年7月19日
皮肉比喩理解のｆMRIによる検討

涌澤圭介, 杉浦元亮, 佐々祐子, ジョンヒョンジョン, 堀江薫, 佐藤滋, 横山浩之, 飯沼一宇, 川島隆太

第29回日本神経科学大会　2006年7月19日
推論と言語算出に基づく言語コミュニケーションに関与する脳内ネットワーク

佐々祐子, 杉浦元亮, ジョンヒョンジョン, 涌澤圭介, 堀江薫, 佐藤滋, 川島隆太

第29回日本神経科学大会　2006年7月19日
健常高齢者における，意味記憶と右側頭葉の局所灰白質量との相関？voxel-based morphometryによる解析？

瀧靖之, 木之村重男, 佐藤和則, 内田信也, 後藤了以, 井上健太郎, 辻一郎, 荒井啓行, 粟田主一, 川島隆太, 福田寛

第29回日本神経科学大会　2006年7月19日
Cortical mechanism of Pictogram processing: an fMRI study 国際会議

Akitsuki Y, Sugiura M, Ikuta N, Matsuoka H, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
The intrinsic oscillations of human visual cortex: the sources of alpha rhythm 国際会議

Wan X, Sekiguchi A, Yokoyama S, Fukushima A, Riera J, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Brain activation associated with the processing of the scrambling: An fMRI study 国際会議

Ikuta N, Kim J, Koizumi M, Saito H, Sekiguchi A, Okamoto H, Suzuki D, Jeong H, Sassa Y, Yokoyama S, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Cross-generational changes of hemisphelic shape of Japanese brains: An MRI analysis 国際会議

Sato K, Kinomura S, Taki Y, Goto1 R, Uchida S, Inoue K, Okada K, Furumoto M, Kawashima R, Fukuda H

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Approaching neuronal computation and functional neuroimaging 国際会議

Riera J, Jimenez JC, Ozaki T, Wan X, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping.　2006年6月11日
An fMRI study of oral translation between Japanese and English 国際会議

Tatsumi K, Ikuta N, Deguchi H, Nagao H, Okamoto H, Sekiguchi A, Sugiura M, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Differential activation patterns between word and sentence translation tasks between Japanese and English: an functional MRI study 国際会議

Tatsumi K, Ikuta N, Deguchi H, Nagao H, Okamoto H, Sekiguchi A, Sugiura M, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Changes of brain activation related to Japanese syntax comprehension in Chinese and Korean natives during learning of Japanese 国際会議

Okamoto H, Bai C, Yokoyama S, Kim J, Uchida S, Jeong H, Sassa Y, Ikuta N, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Effect of motion smoothness on brain activation during dance observation: an fMRI study using a humanoid robot 国際会議

Miura N, Sugiura M, Takahashi M, Sassa Y, Moridaira T, Miyamoto A, Kuroki Y, Sato S, Horie K, Nakamura K, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
A relevant analysis of task difficulty and brain activity during meter inspection: an fMRI study 国際会議

Miura N, Takahashi M, Watanabe J, Uchida S, Sato S, Horie K, Kitamura M, Wakabayashi T, Nakamura K, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Cooking activates bilateral prefrontal cortex, and can be applied as an intervention method to improve prefrontal function of elders. –Bridges between neuroimaging and social science- 国際会議

Iwata K, Yamashita M, Hotehama M, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Mapping cortical networks involved in reasoning using fMRI and DTI tractography 国際会議

Kawashima R, Masunaga H, Horn JL, Sassa Y, Wan X, Sekiguchi A, Uchida S, Sato S, Horie K

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
The Second Language is processed independently of the first language 国際会議

Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Yusa N, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
fMRI evidence for distinct neural substrates for word recognition in L1 and L2 国際会議

Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Neural connectivity among regions related to language function: combined intersubject analysis by functional magnetic resonance imaging and diffusion tensor imaging tractography 国際会議

Uchida S, Miura N, Watanabe J, Kinomura S, Sato K, Taki Y, Inoue K, Goto R, Okada K, Fukuda H, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Learning-induced neural deactivation related to two different modes of second language vocabulary acquisition 国際会議

Jeong H, Sugiura M, Sassa Y, Wakusawa K, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Risk perception: Mechanisms for Processing of Risk-Signals Related to Object and Action-Direction 国際会議

Sugiura M, Sekiguchi A, Wakusawa K, Sassa Y, Jeong H, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Cortical mechanism of feeling inference and speech content production in communication: an fMRI study 国際会議

Sassa Y, Sugiura M, Jeong H, Wakusawa K, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Neural substrates[RK1] underlying individual differences in response to a risky situation: An fMRI study 国際会議

Sekiguchi A, Ikuta N, Sugiura M, Okamoto H, Sato S, Horie K, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping.　2006年6月11日
Explaining: An fMRI Analysis of Two Hypothesized Mechanisms 国際会議

Suzuki W, Jeong H, Sugiura M, Fukushima A, Sassa Y, Wakusawa K, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Cortical Mechanisms of Segmentation in Visual Sentence Comprehension of Japanese Kana 国際会議

Oshima H, Jeong H, Sugiura M, Miyamoto T, Sasa Y, Ikuta N, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Cortical mechanisms of irony and metaphor comprehension: an fMRI study 国際会議

Wakusawa K, Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, Yokoyama S, Tuchiya S, Iinuma I, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Cortical activation related to intellectual excitement 国際会議

Fukushima A, Miura N, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Neural correlates of confidence judgment in retrieved answers: An fMRI study 国際会議

Yokoyama O, Miura N, Watanabe J, Takemoto A, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R, Nakamura K

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Impact of serotonin transporter gene on negative emotion and brain processing during fear conditioning: an event-related fMRI study 国際会議

Mizuno T, Sugiura M, Kano M, Miura N, Watanabe J, Hattori T, Sato S, Horie K, Aoki M, Itoyama Y, Kawashima R, Fukudo S

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Highly proficient group of acquired second language shows larger global and regional gray matter volumes than poorly proficient group –A volumetric analysis and a voxel-based morphometry 国際会議

Taki Y, Okamoto H, Sassa Y, Ikuta N, Jeong H, Horie K, Sato S, Kinomura S, Fukuda H, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Correlations between ischemic white matter lesions and arteriosclerotic risk factors: A voxel-wise multiple regression analysis with automatic tissue classification 国際会議

Kinomura S, Mok K, Lerch J, Goto R, Taki Y, Sato K, Inoue K, Okada K, Kawashima R, Evans AC, Fukuda H

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Global Likelihood Approach to Time Series Analysis of fMRI Data using Nearest Neighbors Autoregressive Model with Exogenous Variables (NN-ARx) 国際会議

Watanabe J, Galka A, Kawashima R, Uchida S, Ozaki T

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
fMRI Evidence for Language Distance through the Trilingual Translation Processes by Korean-Chinese Bilingual learners of Japanese 国際会議

Cui S, Horie K, Iwata K, Sassa Y, Jeong H, Yokoyama S, Lee S, Sato S, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Universal Grammar and Instruction Effects on Second Language Grammar Formation: Evidence from fMRI 国際会議

Yusa N, Koizumi M, Kim J, Saki Y, Kimura N, Uchida S, Yokoyama S, Miura N, Horie K, Sato S, Kawashima R, Hagiwara H

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
The left inferior frontal gyrus subserves the same function in first and second language acquisition: An fMRI study of Japanese transitive verbs 国際会議

Kim J, Koizumi M, Yokoyama S, Uchida S, Okamoto H, Chen B, Kimura N, Sato S, Horie K, Kawashima R

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
Relation of subcortical ischemic white matter lesions to cortical atrophy in aging 国際会議

Mok K, Kinomura S, Ivanov O, Ad-Dab’bagh Y, Lerch J, Singh V, Taki Y, Sato K, Kawashima R, Fukuda H, Evanc AC

12th Annual Meeting of the Organization for Human Brain Mapping　2006年6月11日
前頭前野の発達

川島隆太

第48回日本小児神経学会　2006年6月1日
学習療法国際会議

Kawashima R

Research and Development of Health Care for Elderly　2006年3月16日
脳を知り，脳を鍛える

川島隆太

第34回四国理学療法士学会　2005年11月26日
Spontaneous and event-related EEG correlates of concurrent fMRI

Wan X, Riera J, Kawashima R

平成17年度生理研研究会「神経科学の道具としての機能的ＭＲＩ研究会」　2005年11月24日
Nonlinear Local Electro-Vascular Coupling

Riera J, Wan X, Jimenez JC, Kawashima R

平成17年度生理研研究会「神経科学の道具としての機能的ＭＲＩ研究会」　2005年11月24日
認知症の非薬物療法？学習療法？

川島隆太

第９回茨城県総合リハビリテーションケア学会　2005年11月20日
An effect of word category and morphological complexity on lexical processing in human brain

Yokoyama S, Miyamoto T, Riera J, Kim J, Akitsuki Y, Iwata K, Yoshimoto K, Horie K, Sato S, Kawashima R

The 131st General Meeting of The Linguistic Society of Japan　2005年11月20日
Situation-based and text-based learning of foreign language: An fMRI study 国際会議

Jeong H, Sugiura M, Sassa Y, Horie K, Sato S, Kawashima R

35th Annual Meeting of Society for Neuroscience　2005年11月12日
Cortical mechanisms for visual recognition of one's own face and name 国際会議

Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, Kawashima R

35th Annual Meeting of Society for Neuroscience　2005年11月12日
ヒトにおける様々な高次脳活動について

川島隆太

第５回東海北陸作業療法士学会　2005年11月12日
認知症の新しい非薬物療法（学習療法）の開発

川島隆太

第３回日本神経疾患医療・福祉従事者学会　2005年11月11日
機能的MRIを用いた計器監視課題における難易度と脳活性状態との関連解析

三浦直樹, 高橋信, 川島隆太, 北村正晴, 若林利男

ヒューマンインタフェースシンポジウム2005　2005年9月15日
fMRI を用いたデジタル・アナログ計器監視時の脳活動比較

三浦直樹, 渡邉丈夫, 長倉正人, 岩田一樹, 佐藤滋, 堀江薫, 高橋信, 北村正晴, 川島隆太

第２８回日本神経科学大会　2005年7月26日
Neural network involved in the lexical and morphological processing: An fMRI study

Yokoyama S, Miyamoto T, Kim J, Akitsuki Y, Jeong H, Okamoto H, Sassa Y, Ikuta N, Yoshimoto K, Horie K, Sato S, Kawashima R

第２８回日本神経科学大会　2005年7月26日
言語コミュニケーションに関与する脳活動

佐々祐子, 杉浦元亮, 鄭嫣婷, 堀江薫, 佐藤滋, 川島隆太

第２８回日本神経科学大会　2005年7月26日
日本語を学習した中国語母語話者における、日本語構文の理解に関わる脳活動

岡本英行, 白晨, 横山悟, 金情浩, 内田信也, 高橋大厚, 中村渉, 佐藤滋, 堀江薫, 川島隆太

第１０回認知神経科学会学術集会　2005年7月9日
「日本語文処理の即時性について：意味役割の再分析処理より」

横山悟, 小泉政利, 金情浩, 遊佐典昭, 吉本啓, 川島隆太

日本認知科学会第22回大会　2005年7月9日
Processing of a complex sentence in L1 and L2: An fMRI study 国際会議

Yokoyama S, Okamoto H, Miyamoto T, Kim J, Iwata K, Uchida S, Yoshimoto K, Horie K, Sato S, Kawashima R

Second International Workshop on Evolutionary Cognitive Sciences "In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing, and Neurolinguistics".　2005年7月2日
Neural network involved in verb processing: An fMRI study 国際会議

Yokoyama S, Miyamoto T, Kim J, Akitsuki Y, Riera J, Yoshimoto K, Horie K, Sato S, Kawashima R

Second International Workshop on Evolutionary Cognitive Sciences "In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing, and Neurolinguistics".　2005年7月2日
Brain activation associated with the sentence processing: An fMRI study 国際会議

Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Riera J, Sato S, Horie K, Matsue Y, Kawashima R

Second International Workshop on Evolutionary Cognitive Sciences "In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing, and Neurolinguistics".　2005年7月2日
The brain activation of syntax comprehension in English-Japanese bilinguals: An fMRI study 国際会議

Okamoto H, Takahashi D, Sassa Y, Ikuta N, Jeong H, Iwata K, Watanabe J, Akitsuki Y, Miura N, Kawashima R

Second International Workshop on Evolutionary Cognitive Sciences "In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing, and Neurolinguistics".　2005年7月2日
Brain activities related to the integration of nouns and numeral classifiers in Japanese: An ERP study 国際会議

Sakai Y, Iwata K, Riera J, Wan X, Yokoyama S, Shimoda Y, Kawashima R, Yoshimoto K, Koizumi M

In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing and Neurolinguistics. Center for Evolutionary Cognitive Sciences at the University of Tokyo and Second International Workshop on Evolutionary Cognitive Sciences　2005年7月2日
Organizational Principles Relating Human Brain Structure and Function: Insights from the ICBM Probabilistic Atlas 国際会議

Mazziotta J, Toga A, Evans A, Fox P, Zilles K, Woods R, Lancaster J, Paus T, Amunts K, Iacoboni M, Watkins K, Pol HH, Kawashima R, Mazoyer B, Cannon T, Smith K

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Parietal and Prefrontal Activation Associated with Algebraic Calculation: An fMRI study 国際会議

Watanabe J, Miura N, Iwata K, Sassa Y, Namikawa Y, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Cortical Representation of Multiple Languages: An fMRI Study of Sentence Comprehension by Late Trilinguals 国際会議

Jeong H, Sassa Y, Ikuta N, Okamoto H, Yokoyama S, Horie K, Sato S, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Neural network involved in the lexical and morphological processing: An fMRI study 国際会議

Yokoyama S, Miyamoto T, Kim J, Akitsuki Y, Jeong H, Okamoto H, Sassa Y, Ikuta N, Yoshimoto K, Horie K, Sato S, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
The neural network involved in the processing of give and receive expressions: An fMRI study 国際会議

Yokoyama S, Yusa N, Miyamoto T, Kim J, Jeong H, Okamoto H, Sassa Y, Ikuta N, Yoshimoto K, Horie K, Sato S, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Processing of Scrambled Ditransitive Constructions: An fMRI study 国際会議

Kim J, Koizumi M, Kimura N, Watanabe J, Yokoyama S, Ikuta N, Uchida S, Sassa Y, Akitsuki Y, Iwata K, Jeong H, Miura N, Yusa N, Sato S, Horie K, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Brain Activation Associated with the Japanese Sentence Comprehension 国際会議

Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Watanabe Y, Sato S, Horie K, Matsue Y, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Artifact reduction for simultaneous EEG and fMRI recording 国際会議

Wan X, Iwata K, Riera J, Kitamura M, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping.　2005年6月12日
Brain activation during inspection for digital and analog meters: An fMRI study 国際会議

Miura N, Watanabe J, Nagakura M, Iwata K, Sato S, Horie K, Takahashi M, Kitamura M, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
The Correlation of concurrent fMRI and EEG with visual stimuli in humans 国際会議

Wan X, Riera J, Iwata K, Watanabe J, Kitamura M, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Normal elderly female people have significant positive correlation between cognitive function and volume of the right parahippocampal gyrus. A voxel-based morhometric analysis 国際会議

Taki Y, Kinomura S, Ito H, Goto R, Inoue K, Sato K, Uchida S, Okada K, Tsuji I, Kawashima R, Fukuda H

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Cortical mechanisms of visual word processing: Comparison of Japanese Kana and Kanji processing during semantic and phonological tasks 国際会議

Jeong H, Sugiura M, Sassa Y, Bai C, Miyamoto T, Horie K, Sato S, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Low proficient English-Japanese bilinguals comprehend English using different way from Japanese as mother tongue 国際会議

Okamoto H, Takahashi D, Sassa Y, Ikuta N, Jeong H, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
The comparison between low and high proficient English-Japanese bilinguals in comprehension of second language 国際会議

Okamoto H, Takahashi D, Sassa Y, Ikuta N, Jeong H, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Communicative speech production activates the frontal and anterior cingulate cortices: An fMRI study 国際会議

Sassa Y, Sugiura M, Jeong H, Miura N, Iwata K, Akitsuki Y, Yokoyama S, Watanabe J, Ikuta N, Okamoto H, Uchida S, Riera J, Horie K, Sato S, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
The Japanese Standard Brain Elastically Optimized in Each Age Group 国際会議

Sato K, Kinomura S, Goto R, Taki Y, Uchida S, Ito H, Inoue K, Okada K, Furumoto M, Kawashima R, Hiroshi Fukuda

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
11th Annual Meeting of the Organization for Human Brain Mapping 国際会議

Miyazawa S, Akitsuki Y, Iwata K, Suzuki D, Matsuda Y, Iwasaki S, Sato S, Horie K, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Brain activation compared the Paced Visual Serial Addition Task with the simple addition task 国際会議

Uchida S, Watanabe J, Iwata K, Kinomura S, Sato K, Fukuda H, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Orthogonality of Anterior and Posterior Alpha EEG Activities 国際会議

Iwata K, Riera J, Wan X, Aubert E, Miwakeichi F, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
A first-order bottom-up approach at the micro-columnar level 国際会議

Riera J, Wan X, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Subcortical ischemic lesions detected with tissue classification technique from 3D magnetic resonance images: An aging effect 国際会議

Kinomura S, Lerch J, Signh V, Sato K, Taki Y, Goto R, Inoue K, Uchida S, Ito H, Okada K, Tsuji I, Kawashima R, Evans AC, Fukuda H

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
The role of the Broca’s area and left parietal region during processing of a passive sentence in Japanese: An event-related fMRI study 国際会議

Yokoyama S, Watanabe J, Iwata K, Sassa Y, Akitsuki Y, Miura N, Jeong H, Ikuta N, Okamoto H, Haji T, Usui N, Taira M, Nakamura W, Sato S, Horie K, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Effects of motion and the body part on activation of the left and right cortical networks for visual self-recognition: An event-related fMRI study 国際会議

Sugiura M, Sassa Y, Jeong H, Miura N, Iwata K, Akitsuki Y, Horie K, Sato S, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
Cortical activation involved in the processing of passive sentences in L1 and L2: A functional Magnetic Resonance Imaging study 国際会議

Yokoyama S, Iwata K, Kim J, Jeong H, Okamoto H, Uchida S, Sassa Y, Ikuta N, Nakamura W, Yoshimoto K, Horie K, Sato S, Kawashima R

11th Annual Meeting of the Organization for Human Brain Mapping　2005年6月12日
脳を知り、脳を育む

川島隆太

第43回日本小児歯科学会大会　2005年5月26日
アルツハイマー病の非薬物療法？学習療法について

川島隆太

第46回日本神経学会総会　2005年5月25日
脳科学の視点から新たな認知リハビリテーションの提案

川島隆太

第101回日本精神神経学会総会　2005年5月18日
脳を知り，脳を守り，脳を育む

川島隆太

第3回東北大学バイオサイエンスシンポジウム　2005年5月16日
脳を知り、脳を守る

川島隆太

日本化学会第85回春季年会　2005年3月26日
The Correlation of concurrent fMRI and EEG with visual stimuli in humans

Wan X, Riera J, Iwata K, Watanabe J, Kitamura M, Kawashima R

CREST-RIKEN Workshop "Real-Time Computing and Neural Dynamics in the Brain"　2005年3月2日
The Correlation of concurrent fMRI and EEG with visual stimuli in humans 国際会議

Wan X, Riera J, Iwata K, Watanabe J, Kitamura M, Kawashima R

The 5th International Symposium on Future Medical Engineering based on Bio-nanotechnology 21st Century Center of Excellence (COE) Program　2005年2月15日
イメージングによる脳と心の研究

川島隆太

第９回日本心療内科学会学術大会　2005年1月29日
在宅健常高齢者に対する認知トレーニング介入効果の検討

内田信也, 川島隆太, 寶澤篤, 大森芳, 辻一郎

第63回日本公衆衛生学会総会　2004年10月27日
脳高次機能イメージングの最前線

川島隆太

第22回日本脳腫瘍学会　2004年10月17日
脳を知り、脳を育む

川島隆太

第16回全国生涯学習フェスティバル　2004年10月12日
Functional organization of the human inferior frontal cortex involved in language processingsentences 国際会議

Sassa Y, Jeong H, Okamoto H, Kawashima R

An International Workshop on Language, Brain and Cognition: Linguistic Science at Interdisciplinary Crossroads　2004年10月11日
脳を鍛える〜痴呆の治療と予防〜

川島隆太

日本作業療法士協会第37回全国研修会　2004年10月10日
機能的MRIを用いたメータ監視作業時の脳活動解析

三浦直樹, 渡邊丈夫, 高橋信, 川島隆太, 北村正晴

ヒューマンインタフェースシンポジウム2004　2004年10月6日
タブレット入出力デバイスを利用した脳画像解析支援システムの開発

ウォンヅー, ポーケルビン, 高橋信, 北村正晴, 川島隆太

ヒューマンインタフェースシンポジウム2004　2004年10月6日
Step for fusion of EEG and fMRI 国際会議

Wan X, Iwata K, Riera J, Kitamura M, Kawashima R

57th Annual Meeting of American Clinical Neurophysiology Society　2004年9月29日
情動に関するfunctional MRI？報酬に対する脳活動変化の文脈依存性

秋月祐子, 川島隆太

第27回日本神経科学大会　2004年9月21日
代数的計算の脳活動: fMRI研究

渡辺丈夫, 三浦直樹, 岩田一樹, 佐々祐子, 浪川幸彦, 川島隆太

第27回日本神経科学大会　2004年9月21日
fMRIおよびNIRSデータの融合：ボトムアップアプローチに基づく動的モデル

岩田一樹, Jorge Riera, 川島隆太

第27回日本神経科学大会　2004年9月21日
fMRIによる文理解に関わる脳活動の研究

生田奈穂, 秋月祐子, 佐々祐子, 渡辺丈夫, 岩田一樹, 三浦直樹, 岡本英行, 佐藤滋, 松江克彦, 川島隆太

第27回日本神経科学大会　2004年9月21日
第一言語・第二言語の理解に関わる脳活動領域の特定

横山悟, 内田信也, 岩田一樹, 金情浩, 岡本英行, 鄭嫣婷, 中村渉, 堀江薫, 佐藤滋, 川島隆太

第27回日本神経科学大会　2004年9月21日
L1、L2及びL3間の言語学的類似性と関連する神経機構

鄭嫣婷, 岩田一樹, 渡辺丈夫, 佐々祐子, 生田奈穂, 秋月祐子, 三浦直樹, 岡本英行, 横山悟, Jorge Riera, 土師知己, 臼井信男, 泰羅雅登, 佐藤滋, 川島隆太

第27回日本神経科学大会　2004年9月21日
作業記憶課題における刺激提示速度変化に伴う脳活動量の検討

内田信也, 岩田一樹, 渡辺丈夫, 佐々祐子, 三浦直樹, 木之村重男, 佐藤和則, 福田寛, 川島隆太

第27回日本神経科学大会　2004年9月21日
Comprehension of passive sentences in Japanese: An fMRI study 国際会議

Yokoyama S, Watanabe J, Iwata K, Sassa Y, Miura N, Jeong H, Ikuta N, Akitsuki Y, Okamoto H, Haji T, Usui N, Taira M, Nakamura W, Sato S, Horie K, Kawashima R

The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004年9月12日
The role of linguistic typology in sentence comprehension by multilinguals: An fMRI study 国際会議

Jeong H, Iwata K, Watanabe J, Sassa Y, Akitsuki Y, Ikuta N, Okamoto H, Yokoyama S, Miura N, Riera J, Haji T, Usui N, Taira M, Sato S, Kawashima R

The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004年9月12日
The brain activation of Japanese-English bilingual in sentence comprehension: An fMRI study 国際会議

Okamoto H, Takahashi D, Sassa Y, Sugiura M, Ikuta N, Iwata K, Watanabe J, Akitsuki Y, Miura N, Matsue K, Kawashima R

The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004年9月12日
感性のブレインマッピング

川島隆太

第６回日本感性工学会大会　2004年9月9日
脳を知り、脳を守り、脳を育む

川島隆太

日本カイロプラクティス徒手医学会第６回学術大会　2004年9月4日
日英語における受動文理解に関わる脳活動領域の研究―日本語母語話者を対象としたfMRI実験より

横山悟, 内田信也, 岩田一樹, キムジョンホ, ジョンヒョンジョン, 岡本英行, 渡辺丈夫, 佐々佑子, 三浦直樹, 秋月祐子, 生田奈穂, ホルヘ・リエラ, ワンシャオホン

思考と言語研究会　2004年7月9日
An event-related fMRI study of how active and passive sentences are comprehended in Japanese 国際会議

Yokoyama S, Nakamura W, Watanabe J, Sassa Y, Iwata K, Akitsuki Y, Miura N, Jeong H, Ikuta N, Riera J, Okamoto H, Usui N, Taira M, Sato S, Horie K, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
The role of the left frontal cortex during judgment of grammatical violation: An fMRI study 国際会議

Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Iwata K, Ikuta N, Miura N, Okamoto H, Sato S, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Brain activation during rapid listening with an fMRIstudy 国際会議

Sassa Y, Akitsuki Y, Usui N, Taira M, Kawashima R, Tanaka T, Kubota K

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Parietal and Prefrontal Activation are involved in Algebraic Calculation: An fMRI study 国際会議

Watanabe J, Miura N, Iwata K, Sassa Y, Namikawa Y, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
A bottom-up approach for fMRI and NIRs fusion. I- Theory 国際会議

Riera J, Iwata K, Jimenez JC, Ozaki T, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
fMRI activation maps based on the NN-ARX model 国際会議

Riera J, Bosch J, Yamashita O, Kawashima R, Sadato N, Ozaki T

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
A de-blurring method to remove the effect of nuisance tissues from NIRs signals 国際会議

Riera J, Ripoll J, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
An fMRI study of reading of ancient writings 国際会議

Miura N, Watanabe J, Iwata K, Sassa Y, Riera J, Tsuchiya H, Takahashi M, Kitamura M, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
FMRI Evidence for the Neural Correlates of the Typological Differences among L1, L2, and L3 国際会議

Jeong H, Iwata K, Watanabe J, Sassa Y, Akitsuki Y, Ikuta N, Miura N, Okamoto H, Yokoyama S, Riera J, Haji T, Usui N, Taira M, Horie K, Sato S, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Brain activation with the change of cognitive load during Paced Visual Serial Addition Task 国際会議

Uchida S, Iwata K, Watanabe J, Sassa Y, Miura N, Fukuda H, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Brain activities during evaluation of color combination attractiveness of female faces with makeup: An event-related fMRI study 国際会議

Akitsuki Y, Iwata K, Sassa Y, Miura N, Ikuta N, Jeong H, Maeda Y, Matsue Y, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Brain activities associated with repetition priming effects: An event-related fMRI study 国際会議

Akitsuki Y, Sassa Y, Nakamura M, Awata S, Matsuoka H, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Changes in the activation pattern during the course of sentence comprehension 国際会議

Ikuta N, Iwata K, Sassa Y, Watanabe J, Akitsuki Y, Miura N, Okamoto H, Riera J, Sato S, Matsue Y, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Brain activation during rapid listening with an fMRI study: Effects of training 国際会議

Usui N, Haji T, Nose I, Sassa Y, Kawashima R, Taira M, Tanaka T, Kubota K

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Aging in morphometry - significance vs. inclination of gray matter change 国際会議

Goto R, Kinomura S, Sato K, Taki Y, Inoue K, Ito H, Kawashima R, Fukuda H

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Automatic detection of subcortical ischemic lesion from 3-D MRI data in the aged brain 国際会議

Kinomura S, Lerch J, Zijdenbos AP, Sato K, Taki Y, Goto R, Inoue K, Uchida S, Tsuji I, Kawashima R, Evans AC, Fukuda H

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Standard brain for each age group generated by aging simulation technique 国際会議

Sato K, Kinomura S, Goto R, Taki Y, Uchida S, Inoue K, Ito H, Kawashima R, Fukuda H

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
Depressive subjects have smaller gray matter volume in the prefrontal cortex comparing with normal subjects: A voxel-based morphometry 国際会議

Taki Y, Kinomura S, Goto R, Inoue K, Sato K, Uchida S, Tsuji I, Awata S, Kawashima R, Fukuda H

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
An fMRI study of scrambling effects on sentence comprehension 国際会議

Kim J, Koizumi M, Ikuta N, Fukumitsu Y, Akitsuki Y, Iwata K, Jeong H, Miura N, Okamoto H, Sassa Y, Watanabe J, Yokoyama S, Yusa N, Sato S, Horie K, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
A bottom-up approach for fMRI and NIRs fusion. II- Application to real data 国際会議

Iwata K, Riera J, Kawashima R

10th Annual Meeting of the Organization for Human Brain Mapping　2004年6月13日
脳を知り、脳を育む？脳機能イメージング研究の最前線？

川島隆太

電子情報通信学会ニューロコンピューティング研究会　2004年5月24日
脳を知り、脳を守り、脳を育む

川島隆太

第58回日本栄養・食糧学会大会　2004年5月21日
脳を知り、脳を育む

川島隆太

福岡市民大学講座　2004年5月12日
家庭が子どもの脳を育てる

川島隆太

心の教育・女性フォーラム　2004年5月8日
脳機能から見たコミュニケーション：理論的考察

川島隆太

第１５回日本発達心理学会大会　2004年3月21日
受動文の理解における脳内での処理の負荷

横山悟, 渡辺丈夫, 佐々祐子, 岩田一樹, 三浦直樹, 秋月祐子, 鄭嫣婷, 生田奈穂, ホルヘ・リエラ, 岡本英行, 土師知己, 臼井信男, 泰羅雅登, 中村渉, 佐藤滋, 堀江薫

言語処理学会第10回年次大会　2004年3月15日
SPECT画像による痴呆症の診断システムの研究 (1)機械学習による自動診断

松本怜, 三浦直樹, 高橋信, 北村正晴, 川島隆太, 福田寛

第37回日本エム・イー学会東北支部大会　2003年11月15日
SPECT画像による痴呆症の診断システムの研究 (2)医師との診断戦略の比較

室岡澄子, 松本怜, 三浦直樹, 高橋信, 北村正晴, 川島隆太, 福田寛

第37回日本エム・イー学会東北支部大会　2003年11月15日
脳を知り、脳を育む

川島隆太

第29回日本行動療・学会　2003年10月24日
脳機能最先端科学が明らかにしはじめたこころと癒しのメカニズム

川島隆太

第４回癒しの環境研究会全国大会　2003年8月27日
ブレインイメージングによる顔の個体識別の研究

川島隆太

第26回日本神経科学大会　2003年7月23日
fMRIを用いた文法処理に伴う左前頭葉領域の脳賦活

佐々祐子, 杉浦元亮, 渡邊丈夫, 秋月祐子, 岩田一樹, 生田奈穂, 三浦直樹, 岡本英行, 佐藤滋, 福田寛, 川島隆太

第26回日本神経科学大会　2003年7月23日
主語、目的語、動詞の処理に関わる脳領域

生田奈穂, 杉浦元亮, 佐々祐子, 渡邊丈夫, 秋月祐子, 岩田一樹, 三浦直樹, 岡本英行, 渡部芳彦, 佐藤滋, 松江克彦, 川島隆太

第26回日本神経科学大会　2003年7月23日
Brain activities during evaluation of attractiveness of clothes color combination: An event-related fMRI study

秋月祐子, 杉浦元亮, 渡邊丈夫, 佐々祐子, 粟田主一, 松岡洋夫, 前田泰弘, 松江克彦, 福田寛, 川島隆太

第26回日本神経科学大会　2003年7月23日
ヒト頭頂葉皮質は舌の三次元的運動に関係している機能的磁気共鳴画像法による研究

渡邊丈夫, 杉浦元亮, 前田泰弘, 松江克彦, 福田寛, 川島隆太

第26回日本神経科学大会　2003年7月23日
近赤外線分光法によるヘモグロビン濃度とfMRIによるBOLD信号との相関

岩田一樹, 杉浦元亮, 渡邊丈夫, 秋月祐子, 佐々祐子, 渡部芳彦, 生田奈穂, 岡本英行, 三浦直樹, 前田泰弘, 松江克彦, 川島隆太

第26回日本神経科学大会　2003年7月23日
MRIを用いたヒトの灰白質及び白質の体積、形態変化と年齢及び脳血管障害危険因子との相関

瀧靖之, 後藤了以, 佐藤和則, 木之村重男, 小野修一, 川島隆太, 福田寛

第26回日本神経科学大会　2003年7月23日
Developing your brain by yourself -developing a sound brain and using it wisely 国際会議

Kawashima R

2003 iEARN International Conference　2003年7月20日
学習療法における教材音読が脳活動に与える影響について

臼井信男, 川島隆太, 大野好之, 杉本幸司, 泰羅雅登

日本認知心理学会第１回大会　2003年6月27日
The human parietal cortex is involved in Three-dimensional movements of the tongue: An fMRI study 国際会議

Watanabe J, Sugiura M, Maeda Y, Matsue Y, Fukuda H, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Age-effects on Brain perfusion SPECT in normal subjects : a comparison between standardization with and without anatomical information of MRI 国際会議

Goto R, Kinomura S, Sato K, Inoue K, Sato T, Kawashima R, Fukuda H

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Subcortical ischemic change of the brain correlates with cortical gray matter volume reduction: A morphometric MRI study 国際会議

Kinomura S, Goto R, Inoue K, Taki Y, Sato K, Kawashima R, Fukuda H

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Cortical thinning in normal aging 国際会議

Lerch J, Zijdenbos A, Goto R, Taki Y, Sato K, Kawashima R, Fukuda H, Evans A

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Deformation field as a representation of brain structural changes with aging 国際会議

Sato K, Kinomura S, Taki Y, Goto R, Inoue K, Watanabe J, Ono S, Fukuda H, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Voxel based morphometry of age related structural change of gray matter for each decade in normal male subjects 国際会議

Taki Y, Goto R, Evans A, Sato K, Kinomura S, Ono S, Kawashima R, Fukuda H

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
An fMRI study of sentence reading 国際会議

Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Watanabe Y, Sato S, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
An fMRI study of reading aloud 国際会議

Miura N, Iwata K, Watanabe J, Sugiura M, Akitsuki Y, Sassa Y, Ikuta N, Okamoto H, Watanabe Y, Riera J, Maeda Y, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Brain areas involved in understanding of second language in Japanese: An fMRI study 国際会議

Okamoto H, Takahashi T, Sugiura M, Sassa Y, Ikuta N, Iwata K, Watanabe J, Akitsuki Y, Miura N, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Brain activities during evaluation of attractiveness of color combination: An event-related fMRI study 国際会議

Akitsuki Y, Sugiura M, Watanabe J, Sassa Y, Awata S, Matsuoka H, Maeda Y, Matsue Y, Fukuda H, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Brain Activation Related to Spatial Divided Attention : An fMRI study 国際会議

Iwata K, Sugiura M, Watanabe J, Riera J, Akitsuki Y, Sassa Y, Watanabe Y, Miura N, Ikuta N, Okamoto H, Maeda Y, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Brain Regions Involved in Appetite: An Event-related fMRI Study 国際会議

Watanabe Y, Sugiura M, Watanabe J, Akitsuki Y, Sassa S, Iwata K, Ikuta N, Miura N, Imaizumi O, Watanabe M, Matsue Y, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
A method to estimate neuronal dynamic from BOLD signals 国際会議

Riera J, Watanabe J, Iwata K, Miura N, Aubert E, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
Brain activation of different grammatical processing in Japanese sentences: An event related fMRI study 国際会議

Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Iwata K, Ikuta N, Miura N, Okamoto H, Sato S, Fukuda H, Kawashima R

9th International Conference on Functional Mapping of the Human Brain　2003年6月18日
言語機能の脳イメージング

川島隆太

第４回日本言語聴覚士協会学術集会　2003年6月7日
学習療法の理論的背景と方法論

川島隆太

第14回日本発達心理学会　2003年3月26日
脳を知り、脳を守り、脳を育てる

川島隆太

平成15年電気学会全国大会　2003年3月17日
脳画像のニューロインフォマティクス

川島隆太

第96回つくばブレインサイエンスセミナー　2003年2月18日
脳機能画像データベースシステムの開発

川島隆太

第４回IEEE&SICEセミナー　2003年1月29日
四則演算の脳イメージング？大人と子どもの比較？

川島隆太, 泰羅雅登

認知と記憶の脳内メカニズム　2003年1月16日
Neural basis of learning therapy 国際会議

Kawashima R

1st International Symposium for Learning Therapy　2002年12月14日
視覚的注意の効率的配分に関係する脳領域

岩田一樹, 杉浦元亮, 渡邉丈夫, Jorge Riera, 三浦直樹, 秋月祐子, 佐々祐子, 渡部芳彦, 生田奈穂, 岡本英行, 前田泰弘, 松江克彦, 川島隆太

第２回感性福祉学会　2002年11月15日
視線感知の脳内メカニズム？心の理論の解明をめざして？

川島隆太

第26回日本神経心理学会総会　2002年9月12日
ヒト脳において世界はどのように構成されているか: fMRI研究

杉浦元亮, 渡邉丈夫, 秋月祐子, 佐々祐子, 松江克彦, 川島隆太

第25回日本神経科学大会　2002年7月7日
Effect of alcohol on the activation of the human prefrontalcortex during NO-GO performances: An event-related fMRI study

渡邉丈夫, 杉浦元亮, 井上健太郎, 鐘ヶ江孝, 塚本正次郎, 泰羅雅登, 川島隆太

第25回日本神経科学大会　2002年7月7日
fMRIによる統語処理と意味処理の機能局在化の解析国際会議

佐々祐子, 杉浦元亮, 渡辺丈夫, 秋月祐子, 佐藤滋, 福田寛, 川島隆太

第25回日本神経科学大会　2002年7月7日
Attractiveness of color combination: An event-related fMRI

秋月祐子, 杉浦元亮, 渡辺丈夫, 佐々祐子, 粟田主一, 松岡洋夫, 前田泰弘, 松江克彦, 福田寛, 川島隆太

第25回日本神経科学大会　2002年7月7日
大脳による随意運動の制御

川島隆太

第８回東海脳神経核医学研究会　2002年7月6日
Neuroimaging can be applied to cognitive rehabilitation –concepts and clinical implementations of learning therapy 国際会議

Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Differential activation of temporoparietal structures during recognition of famous names and that of personally familiar names: An event-related fMRI study 国際会議

Sugiura M, Watanabe J, Satoh T, Akitsuki Y, Sassa Y, Imaizumi O, Matsue Y, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Functional anatomy of articulation 国際会議

Sugiura M, Watanabe J, Sassa Y, Akitsuki Y, Maeda Y, Imaizumi O, Matsue Y, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Brain areas associated with humor appreciation 国際会議

Satoh T, Sugiura M, Watanabe J, Maeda Y, Matsue Y, Harada A, Satoh K, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Activation of the left parietal cortex during imagery of taste: An event-related fMRI study 国際会議

Horino S, Sugiura M, Satoh T, Watanabe J, Maeda Y, Matsue Y, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
The different brain network of two groups - relative pitch and perfect pitch 国際会議

Yamashita K, Sugiura M, Watanabe J, Akitsuki Y, Watanabe T, Maeda Y, Matsue Y, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Activation of the right orbitotemporal junction during reading a story: An fMRI study 国際会議

Sugiura M, Watanabe J, Satoh K, Harada A, Yamaguchi K, Itoh M, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
A brain network involved in deception: An fMRI study 国際会議

Kobayashi N, Sugiura M, Watanabe J, Hagimoto S, Horino S, Satoh T, Maeda Y, Matsue Y, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
What factor is associated with global and local changes of white matter in human brain? 国際会議

Taki Y, Goto R, Alan Evans, Ph.D, Alex Zijdenbos, Peter Neelin, Jason Lerch, Sato K, Ono S, Kinomura S, Nakagawa M, Sugiura M, Watanabe J, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Effect of alcohol on the activation of the human prefrontal cortex during NO-GO performances: An event-related fMRI study 国際会議

Watanabe J, Sugiura M, Inoue K, Kanegae T, Tsukamoto S, Taira M, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Difference in brain activation during hearing Japanese sentences containing grammatical error or semantic anomaly 国際会議

Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Sato S, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Cross-generational Changes in Brain Shape of Japanese 国際会議

Sato K, Taki Y, Kinomura S, Watanabe J, Sugiura M, Harada A, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
The left prefrontal cortex plays an important role in imagination 国際会議

Yomogita Y, Sugiura M, Watanabe J, Akitsuki Y, Sassa Y, Sato T, Imaizumi O, Matsue Y, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
8th International Conference on Functional Mapping of the Human Brain 国際会議

Akitsuki Y, Sugiura M, Watanabe J, Yamashita K, Awata S, Matsuoka H, Maeda Y, Matsue Y, Fukuda H, Kawashima R

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Automatic Brain Tissue Segmentation Method from MRI T1-weighted Data 国際会議

Miura N, Taneda A, Shida K, Kawashima R, Fukuda H, Kawazoe Y, Shimizu T

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
Morphological analysis of MR brain images by spherical harmonics 国際会議

Hakoda N, Miura N, Shida K, Kawashima R, Fukuda H, Kawazoe Y, Shimizu T

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
A principal component analysis on whole brain shape utilizing a spherical harmonics expansion 国際会議

Shida K, Hakoda N, Miura N, Kawashima R, Shimizu T, Fukuda H, Kawazoe Y

8th International Conference on Functional Mapping of the Human Brain　2002年6月2日
3次元頭部MRI画像脳領域自動抽出法の提案とその性能評価

三浦直樹, 種田晃人, 志田和人, 川島隆太, 川添良幸, 福田寛, 清水俊夫

情報処理学会第64回全国大会　2002年3月12日
球面調和関数展開による脳表面形状特性解析

箱田直子, 三浦直樹, 志田和人, 川島隆太, 川添良幸, 福田寛, 清水俊夫

情報処理学会第64回全国大会　2002年3月12日
Functional role of the fronto-polar prefrontal cortex in performing the tasks related to the prefrontal cortex: An fMRI study 国際会議

Taira M, Kawashima R, Kubota K

31st Annual Meeting for Society for Neuroscience　2001年11月10日
Brain networks for communication and deception 国際会議

Sugiura M, Kobayashi N, Watanabe J, Hagimoto S, Horino S, Sato T, Maeda Y, Matsue Y, Fukuda H, Kawashima R

31st Annual Meeting for Society for Neuroscience　2001年11月10日
脳科学からみた長寿の工夫

川島隆太

第14回日本健康心理学会　2001年11月3日
脳のはたらきを画像でみる

川島隆太

第16回「大学と科学」シンポジウム　2001年10月27日
個人的知り合いと有名人の名前の認知に関与する脳領域: An event-related fMRI

杉浦元亮, 渡邉丈夫, 佐藤輝幸, 佐藤優子, 前田泰弘, 松江克彦, 原田淳, 佐藤和則, 福田寛, 川島隆太

第24回日本神経科学・第44回日本神経化学合同大会　2001年9月26日
音程と音量認知の大脳メカニズム

山下圭一, 杉浦元亮, 渡邉丈夫, 秋月祐子, 渡辺高志, 前田泰弘, 松江克彦, 福田寛, 川島隆太

第24回日本神経科学・第44回日本神経化学合同大会　2001年9月26日
ユーモアの主観的情動体験に関係する脳領域: An event-related fMRI

佐藤輝幸, 杉浦元亮, 渡邉丈夫, 佐藤優子, 前田泰弘, 松江克彦, 原田淳, 佐藤和則, 萩本繁, 小林奈津子, 堀野智史, 福田寛, 川島隆太

第24回日本神経科学・第44回日本神経化学合同大会　2001年9月26日
The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study

渡邉丈夫, 杉浦元亮, 佐藤和則, 佐藤優子, 前田泰弘, 松江克彦, 福田寛, 川島隆太

第24回日本神経科学・第44回日本神経化学合同大会　2001年9月26日
報酬に対する脳活動変化の文脈依存性: An event-related fMRI

秋月祐子, 杉浦元亮, 渡辺丈夫, 山下圭一, 粟田主一, 松岡洋夫, 前田泰弘, 松江克彦, 福田寛, 川島隆太

第24回日本神経科学・第44回日本神経化学合同大会　2001年9月26日
Can we measure spontaneous thinking? Regional amplitude of low-frequency fluctuation of cortical BOLD signal during resting state and task execution 国際会議

Sugiura M, Kawashima R, Watanabe J, Sato Y, Maeda Y, Matsue Y, Sato K, Harada A, Fukuda H

7th International Conference on Functional Mapping of the Human Brain　2001年6月10日
Different functional roles of human frontal and parietal cortices in memory-guided saccade: An event-related fMRI study 国際会議

Sugiura M, Kawashima R, Watanabe J, Sato Y, Maeda Y, Matsue Y, Sato K, Harada A, Fukuda H

7th International Conference on Functional Mapping of the Human Brain　2001年6月10日
An fMRI study of simple arithmetic –Comparison between children and adults 国際会議

Kawashima R, Taira M, Okita K, Tajima N, Yoshida H, Sasaki T, Sugiura M, Watanabe J, Inoue K, Fukuda H

7th International Conference on Functional Mapping of the Human Brain　2001年6月10日
A functional MRI study of prospective memory 国際会議

Okuda J, Fujii T, Umetsu A, Tsukiura T, Suzuki M, Nagasaka T, Yanagawa I, Suzuki K, Yamadori A, Takahashi S, Kawashima R, Fukuda H

7th International Conference on Functional Mapping of the Human Brain　2001年6月10日
Normal aging and sexual dimorphism of Japanese brain 国際会議

Goto R, Kawashima R, Zijdenbos A, Neelin P, Lerch J, Sato K, Ono S, Nakagawa M, Taki Y, Sugiura M, Watanabe J, Fukuda H, Evans A

7th International Conference on Functional Mapping of the Human Brain　2001年6月10日
Functional MR imaging of cue-invariant shape perception 国際会議

Nakamura K, Kawashima R, Hanazawa A, Sato Y, Sugiura M, Watanabe J, Sato K, Maeda Y, Matsue Y, Fukuda H

7th International Conference on Functional Mapping of the Human Brain　2001年6月10日
Elevation of systolic blood pressure accelerates shrinkage of the gray matter 国際会議

Taki Y, Kawashima R, Goto R, Sato K, Ono S, Kinomura S, Nakagawa M, Sugiura M, Watanabe J, Fukuda H

7th International Conference on Functional Mapping of the Human Brain　2001年6月10日
注意機構の機能画像

川島隆太

第42回日本神経学会　2001年5月11日

︎全件表示 ︎最初の5件までを表示

産業財産権 9

小動物用の脳計測用電極ユニットとそれを用いた測定システム

特許5843201

産業財産権の種類: 特許権
ユーザ見守りシステムおよびユーザ見守り方法

特許6328834

産業財産権の種類: 特許権
コンピュータプログラム、サーバ装置、タブレット型電子機器およびテレビジョン装置接続用電子機器

特許6284171

産業財産権の種類: 特許権
情報処理プログラム、情報処理装置、情報処理方法及び情報処理システム

特許6055186

産業財産権の種類: 特許権
情報処理プログラム、情報処理装置、情報処理方法及び情報処理システム

特許6045175

産業財産権の種類: 特許権
アイウエア（特願2012-122349の分割）

特許5661067

産業財産権の種類: 特許権
アイウエア

特許5661067

産業財産権の種類: 特許権
車両用自律神経機能診断装置、車両用自律神経機能診断方法

特許5390851

産業財産権の種類: 特許権
複数脳賦活観測システム

5280494

産業財産権の種類: 特許権

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 39

脳高次機能イメージング研究競争的資金

2006年3月～継続中
脳ダイナミクス研究競争的資金

2006年3月～継続中
脳科学と教育競争的資金

2006年3月～継続中
オラリティを核とする共在や共感の質の定量評価と介入応用

川島隆太

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2017年7月18日～ 2021年3月31日

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超小型近赤外分光装置を用いた脳活動計測によって、集団会話中の脳活動の同調度を対面会話条件とWeb会議システムを使用したオンライン上での会話条件で比較する実験を実施した。健康な右利きの大学生および大学院生30名を被験者とし、互いに同性で面識のない5名を1組として各条件につき3組ずつグループを形成した。グループごとに指定した話題に関して5分間×6セッションの集団会話をさせた。解析の結果、オンライン会話条件と比較して対面会話条件において、共感や社会的認知に関与する背内側前頭前野および認知制御や言語思考に関与する左背外側前頭前野の脳同調度が特定の周期において有意に高い結果が得られた。
脳血流BFトレーニングシステムの開発と評価

川島隆太

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Challenging Exploratory Research

研究機関：Tohoku University

2015年4月1日～ 2017年3月31日

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機能的MRIを用いた個人脳活動解析によって、食欲の制御に関わる脳領域を同定し、それらの領域内に超小型NIRS装置を用いたバイオフィードバック訓練のターゲット領域が含まれることを確認した。しかし、実生活環境でシステムを稼働させると、ベースラインシフトへの対応、脳活動をフィードバック信号に変換する係数の設定が非常に困難であることが判明し、プログラムの修正を行ったが、目的とする実証実験を行うことができなかった。
過敏性腸症候群の意思決定とその神経基盤

相澤恵美子, 福土審, 虫明元, 川島隆太, 杉浦元亮, 河内山隆紀, 佐藤康弘, 関口敦, 金沢素, 鹿野理子, 森下城, 事崎由佳

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：National Center of Neurology and Psychiatry

2013年4月1日～ 2017年3月31日

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過敏性腸症候群(IBS)はストレスによって腸管の運動機能における異常を示すが、認知機能についてはまだよくわかっていない。直感的意思決定時には、IBS群では健常者と異なるとの仮説をアイオワギャンブリングタスクを用い脳機能画像にて明らかにした。結果は、IBS群ではTask時の最終獲得金額が健常者よりも多く、左背外側前頭前野の有意な賦活が関与していると考えられた。また、全Task施行中の左島皮質と前帯状回の結合がIBS群と健常群では異なることが分かった。脳と腸双方向の応答が活発であるIBS群において、意思決定における脳内神経基盤の形成に、Bodyからのシグナルが関与していることが推測された。
想定外事象発生時の人間の適応行動パフォーマンス向上に関する研究

高橋信, 三浦直樹, 川島隆太, 大橋智樹

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2013年4月1日～ 2016年3月31日

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本研究では、原子力プラントにおける想定外事象発生時の人間の適応的なパフォーマンスを向上させる方策を提案することを目的として、認知工学・心理学・脳科学という多面的な研究パラダイムによる研究を実施した。二つのシミュレーション環境を用いて、想定外事象への対応能力と想定内事象に対する対応能力間に相関があることを示し、更に訓練時の知識の与え方により想定外事象への対応能力が変化することを確認することができた。以上の結果を通じて、想定外事象時の人間行動の評価と向上に関して、今後の訓練及び評価に関して有用な知見を得ることができた。
文理解中の修正機能メカニズムの解明

高橋慶, 川島隆太, 吉本啓, 横山悟, 橋本洋輔

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Young Scientists (A)

研究機関：Tohoku University

2011年4月1日～ 2016年3月31日

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本研究の目的は、日常生活に必要不可欠なコミュニケーション上で誤った言語情報（言い間違い）を人間がどのように柔軟に修正し、再理解しているのか（修正機能）を解明することであった。本機能はコミュニケーション上では必要不可欠であると考えられる。どのように誤情報を再理解しているのかを心理実験や機能的磁気共鳴法（fMRI）により解明することを試みた。その結果、短期的な記憶と再理解が相互的に行われていることが示唆された。
自閉症の発症とセロトニン神経系の発達異常の関連－PETとモデル動物を用いた解析

平岡宏太良, 大隅典子, 住吉晃, 川島隆太

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2013年4月1日～ 2015年3月31日

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転写制御因子Pax6は、大脳、小脳の形成にかかわり神経系の発生発達において重要な因子である。胎生期から成体まで神経幹細胞で発現がみられその増殖と分化のバランスを調整している。ヒトではPAX6の変異のある患者で精神遅滞や自閉症、前頭葉機能障害などの合併が報告されている。本研究ではPax6変異ラットと野生型ラットに対し小動物用MRIにより脳形態画像の撮像を行った。野生型に比べてPax6変異ラットは大脳皮質、海馬、扁桃体、視床、中脳、脳梁の体積が減少していることが明らかとなり、Pax6が高次脳機能の構築にどのように関与しているかについての一端が明らかになった。
脳活動の同期と社会的相互作用の関連の検討

川島隆太

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Challenging Exploratory Research

研究機関：Tohoku University

2013年4月1日～ 2015年3月31日

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超小型近赤外分光測定装置（NIRS）を用いて、背内側前頭前野の活動の同期現象をリアルタイムでモニター可能なシステムを作成し、個体間の社会的相互関係を実社会環境下で定量計測することが本研究の目的である。グループ・ディスカッション時、リズム集団歩行時の脳活動同調を計測した結果、集団インタラクションのあり方の違いに応じた脳活動同調の変化を捉えることに成功した。個人内の脳機能同定を主とする従来研究を越えた個人間の脳活動同調の評価が、共感やコミュニケーションの質などの集団における創発的状態の指標を与える可能性を示唆している。
高齢者の適応的運動訓練と脳活動の関連の解明研究

川島隆太, MAGISTRO Daniele

2012年4月1日～ 2015年3月31日

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認知訓練（ワーキングメモリ（WM）訓練）と有酸素運動の二重課題訓練がそれぞれ片方より、認知機能、脳形態などにより大きな影響を及ぼす、有酸素運動との同時訓練によりＷＭ訓練効果が促進されるとするとの仮説の検証を行い、ＷＭ訓練と有酸素運動の二重課題訓練の認知機能、脳形態へ及ぼす影響を明らかにすることが本研究の目的である。 93名の健康な高齢者(65-75歳)がこの研究を完遂した。これらの被験者はまず、認知テスト、質問紙、MRI撮像などに参加し、その後12週間の訓練期間に入った。その後再び認知テスト、質問紙、MRI撮像などに参加した。12週間の間、被験者は週3回,１回約１時間ほど、訓練に参加した。被験者は３群にWM訓練群、有酸素運動群、両方の同時訓練群(WM訓練＋有酸素運動群)わけられた。結果は、遅延記憶、非言語性推論の検査はＷＭ訓練を含む２群>有酸素のみ、有酸素+WM>WMという傾向はなしというWM訓練がこれらの機能に効果があることを示唆する結果パタンであった。前頭葉機能検査では、ＷＭ訓練を含む２群>有酸素のみ訓練群、有酸素+WM訓練>WM訓練という仮説によく合致する結果が得られた。脳画像の異方性に関しては有酸素運動+WM訓練の群において他の２群に比べ上縦束Iと呼ばれる白質繊維の異方性が有意に上昇していた。脳画像の平均拡散脳に関しては、前頭前野,前部帯状回の各所、海馬、黒質など脳幹周辺の水の拡散性が有酸素運動+WM訓練の群において他の２群より減少していた。このように、WM訓練+有酸素運動の二重訓練は、前頭葉機能や、関連する領域の神経構造に変化を及ぼした。また、WM訓練や有酸素運動の認知機能への効果も確認された。
園芸療法介入による心身機能の改善および心的外傷後ストレス低減の効果の実証

事崎由佳, 川島隆太, 瀧靖之, 竹内光, 関口敦

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2012年4月1日～ 2014年3月31日

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本研究の目的は、東日本大震災で甚大な被害を受けた被災地域住民を対象とした、園芸療法を用いた生活介入により、心身機能の改善や心的外傷後ストレス障害（PTSD）低減の効果を実証する事であった。園芸療法を用いた生活介入では、被災沿岸地域に在住の成人女性54名（介入研究A）と高齢女性39名（介入研究B）を対象とした２つの介入実験を行った。その結果、成人女性の介入研究では、介入群において左前帯状皮質膝下野、左上前頭回の灰白質量の増加、CAPS得点、PANAS PA得点、PTGI-J得点が有意に改善した。また、ストレスマーカーも介入後に有意に低下した。高齢女性対象の場合も介入群では同様の改善が認められた。
感性情報デコーディングシステム開発

川島隆太, 荒木剛, 野澤孝之

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2011年4月1日～ 2014年3月31日

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好感度に関する感性情報を、生活環境下で、脳活動より読み取ることを目的とした。機能的MRIを用いた実験により、物や動物の写真を見たときに、好感度が高い時は、大脳の背内側前頭前野が活動をすることを明らかにした。次いで、多チャンネル光トポグラフィで同様の実験を行い、好感度が高い画像を見た時の脳の反応が、前額正中のセンサーに一番強く表れ、機械学習による感性情報の読み取りが可能であることを明らかにした。最後に、超簡易小型光トポグラフィを前額正中に装着し、日常生活中の背内側前頭前野の活動を計測したところ、好感度の高い状況で脳活動が増加することを個人のデータで検出できた。
運動想起型ＢＣＩへのユーザ適応を促すニューロフィードバック手法の開発

加納慎一郎, 川島隆太, 吉信達夫

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku Institute of Technology

2011年～ 2013年

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ヒトの感覚運動野の脳活動から運動の想起の有無やその種類を検出するBCI（brain-computer interface）における適用性や検出成績を向上させるために，脳波やNIRS（近赤外分光法による脳血流計測）によって得られたヒトの運動想起に伴う脳活動信号から生成された情報をユーザにフィードバックするニューロフィードバック（NF）を用いるための方法論について検討を行った．本実験の結果，計測信号からの情報抽出法，NF実験の実施方法などの知見が得られた．
エンタテインメントが高齢者の心身に与える影響の研究

川島隆太

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Challenging Exploratory Research

研究機関：Tohoku University

2011年～ 2012年

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健康長寿を具現化するために広義のエンタテインメントを利用した生活介入が高齢者の生活の質や認知機能等に与える影響を検証することが目的であった。市販のゲーム、単純な計算や音読を中心とした集団アクティビティと、有酸素運動と無酸素運動を組み合わせた集団アクティビティに関するランダム化比較対象試験を行い、3つの介入手法全てにおいて、実行機能や認知速度の向上を認めた。また遺伝子多形が介入による認知機能向上効果に影響をする可能性を発見した。
人間の言語理解中における情報補完プロセスの解明

高橋慶, 横山悟, 吉本啓, 川島隆太

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Challenging Exploratory Research

研究機関：Tohoku University

2010年～ 2012年

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人間が文を理解する際に必要な情報が欠けている場合、どのように予測、補完を行っているのかを明らかにする事を目的とした。先行研究では文理解中に予測、補完処理が行われることが指摘されていたが、その神経基盤は解明されていなかった。そこで本研究は脳機能計測手法を用いることにより、脳内の予測、補完処処理に関与する神経基盤の解明を試みた。その結果、言語関連領域を中心に有意な脳活動を観察した。このことから、人間は文理解中に実際に現れていない情報についてもすでに先に統語・語彙意味処理していることが示唆された。
ディスレキシアの言語トレーニングに関する行動科学及び神経科学的研究

川島隆太, MAIONCHI-PINO Norbert AlainRomuald, MAIONCHI-PINO Norbert Alain Romuald

2010年～ 2012年

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本研究課題の目的は、日本語-フランス語間の対照言語学的実験研究を通して、両言語を母語とする読み書き障害を持つ子供に対するウェブベースの改善プログラムを構築することである。上記の目的を達成するために、23年度は健常な日本語母語話者とフランス語母語話者の小児(8～12歳)を対象として音声の聞き分け実験を行なった。被験者は日仏合計で350名以上であった。なお、実験に際しては東北大学医学研究科の倫理委員会で承認済みである。その結果、音節の区切りに関して日本語母語話者、フランス語母語話者に共通した音韻処理方策、言語ごとの音韻理解上での制約を見いだし、心理実験の結果、その制約が階層性をなしていることが分かった。現在本結果を22年度に行なった成人を対象とした実験結果と照らし合わせ、発達と音韻処理の関係について考察中である。なお、本結果は先行研究の結果とも矛盾しないものであった。成果発表として、国際学会で発表を行なった。現在は本実験結果を元に脳波・脳磁図実験の準備中である。本実験は、音韻特性の階層性を脳内神経レベルで検査するものである。具体的には、ベースラインとなる音と、音韻素性を操作した音2種類を用意し、被験者に受動的に聞かせ、異なる音韻素性を処理した際に無意識にどのように脳内で反応が起こるかを調べる。同実験は始めに健常成人を対象に行なう。読み書き障害を持つ児童はこの聞き分けがうまく出来ないことが言語障害と関連していると仮定しており、同障害を持つ児童についても検査を行なう予定である。なお、実験刺激、プロトコルは心理実験で用いたものと同一にする予定である(倫理委員会で承認済み)。
心身症に共通する心理的背景の神経基盤の解明

関口敦, 川島隆太, 杉浦元亮, 事崎由佳, 福土審, 森下城, 相澤恵美子

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2010年～ 2011年

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心身症の心理的背景である『ストレス脆弱性』と、ストレスが身体症状に転換する『身体化』の神経基盤を、脳機能画像技法を用いて解明した。研究結果から、『ストレス脆弱性』の神経基盤として、前帯状皮質および背外側前頭前野が、『身体化』の神経基盤として前島皮質および体性感覚野が有力な候補と考えられた。本結果は、心身症の治療戦略として、表現型としての身体症状のみならず、共通した心理面への介入の有効性を示唆するものである。
脳科学的知見に基づく原子力プラント運転員のヒューマンファクタ研究

高橋信, 川島隆太, 三浦直樹, 松山茂男

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2009年～ 2011年

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携帯型のNIRS装置を用いて、原子力発電所の制御室における運転員の脳活動測定を実現することを最終目標に研究を行い以下の成果を得た。・実験用加速器制御室において運転操作中の操作員に対してNIRS装置による脳活動計測を行い、計測が可能であることを確認した。・新たに開発された超小型NIRS装置により、フルスコープシミュレータにおいて当直長を含む四名の脳活動の同時計測を実施し、フルスコープシミュレータという実環境に極めて近い環境において、複数の運転員の脳活動を同時に計測できることを確認した。
情報系科目を対象とした自己組み立て型学習に関する実践的研究

丸岡章, 川島隆太, 邑本俊亮, 瀧本英二, 天野一幸, 原口和也

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Ishinomaki Senshu University

2008年～ 2010年

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本研究で得られた成果のひとつにある組み合わせ論的パズルのインスタンスを生成するアルゴリズムを与えたというものがある。このパズルは計算ブロックパズルと呼ばれるもので、そのインスタンスは、nxn格子面の連結するブロックへの分割と各ブロックへの正整数の割り当てとして与えられる。そしてこのパズルは、格子面の各マスに{1,2,…,n}の整数を次の2条件を満たすように割り当てることを求めるものである。この2条件とは、各行、各列には、{1,2,…,n}の整数が1回ずつ現れるというラテン方陣条件であり、他の条件は、各ブロックのマスに割り当てられた数の合計が、そのブロックに割り当てられた整数の合計に一致するという部分条件である。このアルゴリズムは、パズルを解くときに使う推論規則としてパラメータを与えると、難易度を指定できるようになっている。そして、認知心理実験を行い、その難易度のインスタンスが生成されることを検証した。
脳波を用いたユーザ適応型ヒューマンインターフェース(BCI)のシステム化

加納慎一郎, 吉信達夫, 川島隆太, 星宮望, 半田康延, 星宮望, 半田康延

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2007年～ 2009年

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従来の非侵襲計測によるBCI(brain-computer interface)で問題になっていたユーザへの適応性を改善する方法論を提案し,ユーザ適応性の高いBCI を実現するための手法を検討した.運動のイメージによって生じる脳活動を検出するBCI のための特徴抽出,パターン分類,ユーザ訓練の手法を脳波,近赤外分光法(NIRS),機能的磁気共鳴画像法(fMRI)により検討した,また,事象関連電位を用いたBCI を開発し,そのユーザへの適用性の向上のための検討を行った.
非侵襲的脳機能イメージングによるストレス・疲労の自己定量化システムの開発

川島隆太

2007年～ 2008年

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疲労やストレスによるパフォーマンスの低下が、脳のどの領域の働きの変化と関連するのかを、非侵襲的脳機能イメージング手法を用いた基礎研究によって明らかにし、さらに、認知心理学的研究を追加することによって、健常成人の疲労やストレスによる認知機能の変化を定量的に評価可能なシステムを開発することが本研究の目指す最終的な目的である。平成20年度は、機能的NIRsを用いて、健康な右利き大学生6名を対象として、連続単純計算による精神疲労負荷時の前頭前野活動を計測したが、疲労に伴う変化を計測できなかった。このため、精神疲労モデルを再構築することが必要であると判断し、心理学研究を展開した。健康な右利き大学生30名を対象として、内田クレペリンテスト(連続単純計算)による精神疲労の状態を、認知心理学的手法によって経時的に観察した。その際に、バランス栄養流動食を摂った場合と、水のみ摂取した場合の2条件を設定した。水のみ摂取した場合には、VAS法による精神疲労の内観が時間と共に増加し、単純計算の作業量も減少する傾向にあったが、流動食を摂った場合には、開始後1時間半までは、精神疲労の内観も単純計算の作業量も減少しないこと、1時間半以降は、水のみ摂取群と同様に精神疲労度の内観も、作業量も低下することがわかった。先行研究では、ブドウ糖のみ摂取した場合には、水のみ摂取と同じ疲労傾向を示すこともわかっており、朝食の摂取パターンによって、精神疲労とそれに伴うパフォーマンスの低下の程度に差が出ることがわかった。
脳科学的アプローチよる第二言語産出の研究

川島隆太, JEONG H., JEONG. H.

2007年～ 2008年

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本研究では、第二言語を産出する際に関わる神経モジュールを特定するために、英語を第二言語として習得している日本語母語者話者30名を対象とし、脳機能画像法(fMRI)を用いて、第二言語産出時の脳活動を測定する二つの実験を行った。一つ目の実験では、英語を用いて対人コミュニケーションを行う際(リアル・コミュニケーション条件)の脳活動と、すでに作られている動画に向かって話かける際(動画コミュニケーション条件)の脳活動を比較した。二つ目の実験では、状況を単に記述する言語産出タスクと場面や相手に応じて言語産出するタスクを遂行する際の脳活動を測定し、比較した。両の実験では、コントロールタスクとして母語を用いて同様のタスクを実施した。分析結果、第二言語の言語産出は、母語よりもブローカ野を中心とする運動性言語領域、音韻作動記憶を担う前頭野と頭頂葉が有意に活動していること、さらに、使用場面やタスクの種類によって関連する神経基盤が異なることが分かった。特に、リアル・コミュニケーション条件と場面や相手に応じて言語を産出するタスクは、それぞれの比較タスクよりも、社会認知に関与する領域(両側の上側頭溝後部、内側前頭皮質)で有意な脳活動が測定された。これらの結果から、(1)第二言語を産出する際に関与する神経基盤は、言語産出領域だけではなく、社会性の認知に関わる神経モジュール(前頭前野の内側部や側頭回の前部など)が関与していること、(2)使用場面やタスクの種類などの要因が第二言語産出時の脳活動に影響を及ぼすことが示唆された。
インタフェース技術の脳科学からの知見に基づく高度化

高橋信, 川島隆太, 杉浦元亮, 川島隆太, 杉浦元亮

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2006年～ 2008年

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本研究では、機能的MRIを用いた脳機能解析の手法を応用し、インタフェースと対峙した人間の認知的挙動と脳活動の関係を解明し、インタフェース評価へ脳機能解析を適用する手法を構築することを目的として「脳に優しい」インタフェース実現のための方法論の構築を行った。本研究においては、異なる視点からの三つの被験者実験を行い、インタフェースの高度化に対して、脳科学的な知見が有効であることを示すことができた。
文字を「書く」ことの活動に関する科学的・実証的研究

川島隆太, 久米公, 生田菜穂, 浜本純逸, 大内善一, 鈴木慶子, 林朋美, 川島隆太

2005年～ 2006年

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1.報告書(冊子体)の発行 H19.3に、下記の章立ての研究成果報告書(A4版、全87頁)を発行した。序(川島) §1 硬筆による手書き活動時の脳活動に関する報告(鈴木・林・生田) §2 毛筆による手書き活動時の脳活動に関する報告(久米・鈴木・生田) §3 書字習慣に関する報告 ∫1 「メモをとると話しがよく理解できるか」に関する実験(鈴木・林・浜本) ∫2 「ノートとメモに関するアンケート」調査 §4 書字習慣と教科教育 ∫1 手書きメモと脳の活性化(浜本) ∫2 「手書き」を再定義する(鈴木) 「あとがき」にかえて(久米) 2. 成果 1)小学生を対象にして、硬筆を使用した5つ(視写1、視写2、聴写、暗写、単純計算)の書字活動の、脳活動をNIRSにより測定した。その結果、4つの文字を書く活動は、単純計算よりも、脳を活性化することがわかった。 2)中学生では、話しを聞くとき、メモを取る者と、メモを取らない者に分かれた。別途、行ったアンケートやテストの結果から、メモを取る者には、下記のような特徴が見られた。 (1)自発的にノートを取る者が多い。 (2)国語テスト得点が中位の者が多い。 (3)備忘メモを必ず取る者が多い。 (4)情報メモを必ず取る者が多く、ときどき取るじゃが少ない。 (5)ひらめきメモをまったく取らない者が少ない。 (6)手で文字を書くことが嫌いな者が少ない。 3)アンケートの結果、手で字を書くことが好きな者は、情報メモ及びひらめきメモを取る傾向がある。以上から、書字活動と知的創造的活動とは関連していることが予測できるので、今後は、その方向で研究を進めていきたい。
人間の高次脳機能を育む手書き活動に関する調査研究

鈴木慶子, 久米公, 浜本純逸, 大内善一, 川島隆太, 生田奈穂

2005年～ 2005年

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本調査研究は、文字を手書きする活動と脳の活性化との関係について調査し、文字を手書きする活動の、教育の場における価値を科学的に評価しようとすることを目的とした。そのために、2つの生活介入調査(4週間)と一つの書字習慣調査(1〜2週間)を行い、下記のような構成の報告書を編集発行した(H18.3.31発行予定)。序 (鈴木) §1 ニュースの聞き取り調査に関する報告 (鈴木・林・生田) §2 朗読の聞き取り調査に関する報告 (鈴木・林・生田) §3 「手書き指数」算出のための基礎調査に関する報告 (鈴木・林) §4 本調査研究の価値と展望 ∫1 国語教育における価値と展望 (浜本) ∫2 書写教育における価値と展望 (久米) ∫3 脳科学における価値と展望 (川島) 研究組織結果としては、今回の調査では介入期間が短く、また被験者数が統計的に不十分であったために、文字を手書きする活動がそれ以外の認知機能を向上させるという点については認められなかった。しかしながら、いくつかの点で、私たちの仮説の正当性を裏付けるデータが出ている。書字を用いた生活介入を大学生などを対象にして長期間続けることは、本調査研究の規模では不可能であるため、将来は、横断的なコホート研究を行うべきであろう。その基盤として、書字の習慣を指数化する方法である「手書き指数」を開発していくことが有効であると考える。
相補的複合脳機能イメージングによる論理的思考活動の研究

川島隆太

2005年～ 2005年

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本研究の目的は、「論理的思考力」を司る脳の巨視的回路網活動の時空間パターンを、機能的MRIによるBOLD情報と脳電図による脳電位情報を数学的に融合する最先端手法を用いて定量的に評価することである。健常右利きの若年ボランティア10名を東北大学の大学生及び大学院生から募集した。ヘルシンキ宣言に則り、各被験者には、実験の目的・安全性について口頭及び書面により説明したのちに書面による同意書を得た。論理的思考力を評価する認知心理課題は、トポロジーテストを用いた。トポロジーテストは、心理学的に論理的思考力、特に推論の能力を評価するために開発されたものである。トポロジーテスト遂行中の脳活動を、事象関連法を用いて、1.5T機能的MRIおよび64チャンネル脳電図計によって計測した。機能的MRIによる計測によって、トポロジーテスト遂行には、左右半球の背外側前頭前野、運動前野、頭頂連合野、下側頭回、外側後頭葉を含む広範なネットワークが活動することがわかった。多チャンネル脳波計によるシータ波の電源推定では、左右半球の背外側前頭前野、運動前野に電源が推定された。シータ波は内的思考活動と関係があることが知られており、機能的MRIの実験結果と一致する。さらに、DTIを用いた領域間の神経線維の結合性の解析によって、外側前頭前野の領域は、同側半球の頭頂間溝領域、運動前野との連結が強いこと、運動前野の領域は、対側の運動前野、左半球の頭頂間溝領域との連結が強いことが示唆された。運動前野と頭頂間溝領域との連結は非対称的であった。トポロジーテストを用いた推論を行っている時には、主に左半球の頭頂間溝領域、左右両側半球の前頭前野と運動前野を結ぶネットワークが使われていたと考えられる。
機能的MRI及び近赤外線計測による感情の脳内表象の研究

川島隆太

2003年～ 2003年

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認知・記憶・感情などに伴う脳活動を局所脳血流量を指標として画像化できる機能的MRI装置と、局所酸化ヘモグロビン量・局所還元ヘモグロビン量を指標として画像化できる近赤外計測装置を組み合わせて使用することにより、健常人の感情の表出に伴う脳活動の時空間パターン表現を明らかにし、感情を司る脳内メカニズムを考察することが研究の目的である。まず、右利き健常被験者60名(ヘルシンキ宣言にのっとり、被験者自身に実験の目的と安全性に関して口頭及び書面にて説明を行い、書面にて同意を確認)を対象として、機能的MRIを用いて、色の組み合わせの好き・嫌いを判断する課題を施行中の脳活動を計測した。この課題は被験者の感情を誘発する課題として作成した。課題では単なる色の組み合わせから、服装や化粧といった社会的な価値判断も伴うような色の組み合わせまで、数種類の異なったレベルの視覚刺激を用意する。課題は事象関連デザインとし、「好き」「嫌い」「どちらでもない」のそれぞれの判断をした時の脳活動を独立に解析した。それぞれの課題において、大脳右半球の外側前頭前野や基底核が「好き」の感情発現に、両側半球の側頭葉内側面は「嫌い」の感情発現に特異的な活性化を占めることが示唆された。この結果から、視覚刺激情報に対する「好き」「嫌い」の感情の発現には、異なった大脳皮質を含むネットワークの活動が関与することが示唆された。大脳右半球前頭前野の活動は、他の先行研究においても、視覚的に提示された写真に対する「好き」の判断との関係が示唆されており、ポジティブな感情発現との関連が強く示唆される。さらに、感情の表出に関する脳活動の時空間パターンを定量解析するために、機能的MRIによる脳活動の空間パターン情報と近赤外計測装置による脳活動の時間パターン情報を融合する数学モデルの作成を行った。
非侵襲的イメージング手法による脳機能の加齢変化の研究-相補的融合画像による時空間パターン解析-

川島隆太

2000年～ 2000年

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健常右利き若年男性5名を対象として、ポジトロンCT及び脳磁図による脳機能計測を行った。ポジトロンCTでは、さまざまな人の顔の写真をコンピュータにより提示し、それらの顔が既知の人のものか、未知の人のものかを弁別する課題遂行中の脳血流の変化を測定し、コントロール課題と比較した。脳磁図では、既知の顔、未知の顔の提示に関連した、脳磁界の変化を計測した。ポジトロンCTデータは、被験者個人ごとに統計解析を行い、脳賦活地図を作成した。脳磁図データは、ポジトロンCTデータとの重ねあわせを行うために、2つの異なった方法による解析を試みた。まず、ポジトロンCTによる脳賦活地図を利用して、脳賦活の認められた領域内にのみ双極子を強制的に推定させた。ついで、被験者の脳表面にポジトロンCTデータと同程度の空間解像度をもつ機能単位を想定し、その上に脳磁図データを展開する、BET(Brain Emission Tomography)と呼ばれる手法を用いた。ポジトロンCTデータより、顔の既知・未知の弁別には、外側後頭葉、側頭葉下面、側頭葉内側面、側頭極に脳賦活を認めた。脳賦活領域上に双極子を計算する方法では、側頭葉下面、外側後頭葉、側頭葉内側面に、それぞれ画像提示後160、180、200ミリ秒後に活動が計算できた。側頭極では計算が発散してしまい双極子は同定できなかった。BETでは、外側後頭葉と側頭極にそれぞれ画像提示後200、270ミリ秒後に脳賦活を認めた。ポジトロンCT画像情報とBETの情報は、違いに独立なため、これらの画像情報の融合を数学的に行うことにより、脳活動の時空間パターンは検討可能と思われた。
心の発達:認知発達障害

小嶋祥三, 長崎勤, 辰己格, 杉下守弘, 川島隆太, 山本淳一

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research on Priority Areas (A)

研究機関：Kyoto University

1997年～ 2000年

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計画研究「心の発達:認知発達障害」は特定領域研究に相応しい、障害の先端的な研究を目指した。その一つは障害児研究への新しい研究法の導入である。コンピュータを用いた障害児の行動改善指導法を確立する一方、スクリプトによる障害児のコミュニケーション行動の分析、指導の研究を行った。もう一つは機能脳画像法による障害の基礎的な研究である。現在、ポジトロンCTや機能的MRIを障害児に適用することは難しい。そこで老齢者を含む成人で将来の障害児の脳画像研究を見据えた基礎的な研究を行った。この他に、老齢ザルの認知機能の研究も実施した。障害児のコンピュータ支援指導では、家庭に訓練用のコンピュータを導入した。それによって多数回の、安定して、きめの細かい指導が可能になり、有効だった。訓練は刺激等価性のパラダイムに基づいて行われたが、平仮名の聞き取り、漢字の獲得などで成果を挙げた。スクリプトによるコミュニケーションの分析では、心の理論の基盤をなす、他者の意図の認識が自閉症児はもとより、ダウン症児でも十分でないことが明らかになった。機能脳画像の研究では、心の理論などで話題になっている視線の検出に扁桃核が関係することを明らかにした。しりとり課題が半球優位の決定に有効であることが分かった。また、オノマトペが実際の事物とその名称(言語)の間のギャップを埋める可能性が示唆された。失語症の言語の再獲得に利用可能かもしれない。また、高齢者では語想起において左側頭部、左前頭部の活動が低下していた。高齢者の喚語困難の基盤をなすと思われる。最後に、老齢ザルの認知機能の研究では、学習セットの形成が困難なこと、連続逆転のエラー・パターンの分析などから、前頭葉の眼窩面の機能低下が推定された。老齢ザルは刺激の変化による妨害効果を受けやすい傾向が強かった。ヒトと共通するだろう。
PETおよびfMRIによる高次体性感覚に対する主観的注意の機能解剖研究

川島隆太

1999年～ 1999年

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ヒトにおける視覚-体性感覚の異なったモダリティー間での情報の統合に関する処理機構を明らかにした。右利き若年男性健常被験者9名を対象とした。局所脳血流量をポジトロンCT装置を用いて計測した。課題は、視覚-視覚課題(VV)、体性感覚-体性感覚課題(SS)、視覚-体性感覚課題(VS)、体性感覚-視覚課題(SV)、を行わせた。被験者の右手の親指と人さし指に、仮想空間上で物体を触知できる反力装置の指サックを装着させた視覚刺激として直径の異なる円柱を作成した。また体性感覚刺激として、同じ円柱の前面にスクリーンを設置し円柱は把握可能だが直接は円柱は見えない刺激を作成した。右前頭前野と左小脳後葉外側は、全ての課題で賦活される傾向にあった。これらの領域は、作動記憶やマッチングに関与すると考えられた。右背側運動前野は、VS課題に特異的に活動を示した。異なったモダリティー情報が交錯するマルチモダル領域である可能性を考えた。右腹側運動前野は、SS課題とVS課題でのみ活動を示した。知覚している体性感覚情報を、他の情報と比較することに関与すると考えられる。頭頂間溝領域前部は、SS・VS・SV課題で賦活した。この領域は体性感覚情報処理に関与していると考えられた。下側頭溝領域はVV課題とVS課題で賦活を示した。視覚情報の作動記憶に関与すると考えられた。視覚と体性感覚のクロスモダルマッチングは、先にどちらの情報を作動記憶に貯えるかにより、2つの異なった経路により処理されることが示唆された。まず体性感覚情報を記憶しこれを視覚情報と比較する時には、それぞれのモダリティー情報を処理する領域の活動のみが必要で、情報はその領域間をもれ伝わるとの仮説、そして視覚情報を記憶しこれを体性感覚情報と比較するときには、モダリティー特異的な情報処理領域の他に、マルチモダル領域で情報処理が行われるとの仮説を示唆した。
PETによる高次体性感覚機能に対する主観的注意の機能解剖研究

川島隆太

1998年～ 1998年

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視覚的に提示された物体を道具を用いて把握するときのヒトの脳活動を検討した。正常右利き若年男子8名を対象とした。全員書面による同意書に署名をした。実験では被験者の胸の上方に30cm四方のボードを設置した。このボード上には、右下の角からボードの下面に対して30度と60度をなす2種類の平行線が引かれている。被験者の右手に実験中常に火ばしを保持させた。被験者はポジトロンCT撮像中に次の4つの課題を行った。1)コントロール課題:被験者に火ばしを保持したまま運動を行わず、ボードの中央を見つめているよう指示した。2)ポイント課題:被験者に30度と60度の平行線領域を交互に右手の人さし指で触るよう指示した。3)把握課題:被験者に、30度と60度の平行線領域のどちらかに置かれた発砲スチロール製の円柱を右手の人さし指と親指で摘み、もう一方の領域内に交互に置くように指示した。4)道具課題:被験者に、30度と60度の平行線領域のどちらかに置かれた発砲スチロール製の円柱を右手に保持した火ばしで摘み、もう一方の領域内に置くように指示した。ポジトロンCT装置はと酸素15標識水を使用して局所脳血流画像を撮像した。各被験者の脳血流画像は各被験者の脳MRI画像をもとにして、流体画像変型システムを用いて解剖学的標準化を行い、その後、SPM96を用いて統計的に有意な血流増加を示した領野を同定した。コントロール課題と比較して、各運動課題では、左頭頂連合野・左一次運動感覚野・左被殻・右前頭前野・右上側頭回・帯状回などの領域の賦活が認められた。把握課題および道具課題では、これらの領域に加えて、左半球頭頂溝領域と後帯状回領域に有意な活動が認められた。この活動はポイント課題と比較しても有意であった。大脳右半球の頭頂間溝には道具課題遂行時にのみ有意な活動を示す領域が観察された。
ヒト脳機能地図とその国際データベース化の研究

福田寛, 木之村重男, 川島隆太, ZILLES Karl, ROLAND Per E

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for international Scientific Research

研究機関：TOHOKU UNIVERSITY

1997年～ 1998年

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1. コンピュータ化脳図譜システムの開発と性能評価ドイツ側(Zilles教授)が中心となり、日本側が協力して開発した自動化コンピュータ化脳図譜システムの性能評価を行った。日本人MRI画像を用いた検討では、脳形態標準化後の空間的誤差は1mm以下であり、現在世界中で用いられている他のシステムよりも誤差が1桁少ないことを証明した。本システムは日本人に適応可能であり、ポジトロンCTによる脳機能地図作成研究のみではなくfMRIを用いた研究にも応用可能であることを示した。 2. 認知/運動課題遂行に関連する脳機能地図作成スウェーデン側(Roland教授)と分担して、認知/感情/運動課題遂行に関連する脳機能部位をポジトロンCTを用いて同定した。視線の認知機構・自己の顔の認知機構・触覚の認知機構・自発運動制御機構などを明らかにして、機能地図データベース作成の為のデータベースコンテンツ化を行った。 3. 国際脳形態画像データベース作成と日本人標準脳形態の決定カナダ側(Evans教授)と共同研究会議を開催し、ドイツ側(Zilles教授)も交えて、日本・北米・欧州の3地域での国際脳形態画像データベースを作成することに合意した。それぞれの地域で300名分の健常者脳MRI3次元画像を撮像し、共通の空間座標システム上に配置することにより、相互連関可能な共通データベースを作成することとした。このための日本人脳形態画像の取得を行った。上記国際脳形態画像データベース作成用にカナダ側より提供された、脳MRI画像を標準空間座標上に自動変換するプログラムを応用して、150名分の日本人脳MRI画像を使い、日本人標準脳形態を決定した。さらに、日本人とドイツ人の若年男女112名の脳MRI画像データを用いた脳形態の民族差の比較研究を行った。
PETによる高次視覚機能に対する主観的注意の機能解剖研究

川島隆太

1997年～ 1997年

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我々はさまざまな奥行き情報を統合して三次元的な形態や空間を認識していることが心理学的に証明されている。しかし、脳内でのこのような視覚情報処理機構に関してはほとんど解明されていない。そこで本研究では、ポジトロンCTを用いて、三次元的な視覚情報処理に関与して活動を示す巨視的な神経回路の特定を行った。正常右利き若年男子6名を対象とした。被験者はポジトロンCT撮像中に次の2つの形態の識別課題を行った。 1)三次元形態の識別課題(3D):被験者にコンピュータグラフィクスで作成した三次元図形(六角錐)を視覚刺激としてHMDを使って立体視させた。刺激は見た目は変わらないが凹凸の程度が違っていて、見本と同じ凹凸の刺激が提示された時に右手でボタンを押して合図をさせた。 2)面の傾き識別課題(3DS):被験者にコンピュータグラフィクスで作成した平面を視覚刺激としてHMDを使って立体視させた。被験者は面の三次元的な傾きに注目して、見本と同じ傾きの刺激が提示された時に右手でボタンを押して合図をさせた。それぞれのコントロール課題として、同じ視覚刺激セットをもちいて、見本刺激提示直前に提示される手掛かり刺激がでたときに右手でボタンを押して合図をさせた。3DS課題・3D課題ともに大脳右半球頭頂間溝皮質に有意な血流増加を認めた。左半球では有意な血流増加は認められなかった。 3DS課題で賦活された領域は、3D課題で賦活された領域よりも前方側に位置していた。本研究結果は、三次元構造認識のためのニューロン機構が頭頂間溝領域にあることを示した。さらに我々の最近の研究より、二次元の線分の角度の弁別を同様な遅延見本合わせ課題を行わせた場合でも、大脳右半球の頭頂間溝皮質に賦活が認められることが明らかにされており、右半球の視覚的な物体の立体的構造の情報処理における特異性の存在が示唆される。
認知発達の機構

桐谷滋, 川島隆太, 杉下守弘, 小嶋祥三, 大津由起雄, 波多野誼余夫

1996年～ 1996年

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次年度以降の重点領域研究「心の発達-認知的成長の機構」実施のために、対象研究領域(概念発達、言語発達、認知発達障害)の研究動向の展望と、必要研究課題の検討を行った。このためにシンポジウム、認知・言語の成立(平成8年10月、重点領域研究:認知言語の成立と共催)、認知発達研究における言語・文化間比較(平成9年1月)および研究会、脳機能計測の最近の話題(平成8年12月)を開催した。前記シンポジウムでは、知識の獲得と改定の発達過程(波多野)、文法知識の獲得課程(大津)、音声コミュニケーションの発達過程(桐谷)、動物と人の音声能力の比較(小嶋)についての研究課題の整理、提案がなされた。後者のシンポジウムでは、特に発達研究における言語・文化間比較による接近について議論され、人以外の霊長類における社会文化的現象(松沢)、言語の地域・社会差の現象(日比谷)、脳機能の言語間比較(川島)の研究の動向と可能性が検討された。脳機能計測の研究会では各種計測手法の現況と発達研究への応用可能性が検討され、又、特にPETを用いた画像および音声認知機能について実際に就験的実験を行い、今後の実験に関する具体的指針を得た。以上を通じ概念発達については素朴理論を中心に領域固有性および制約の要因を重視して研究をすすめること、言語発達については普遍文法と経験の相互作用について研究をすすめること、認知発達障害については脳機能計測を中心にすすめることの指針を得た。
PETによる高次視覚機能に対する主観的注意の機能解剖研究

川島隆太

1996年～ 1996年

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視覚対象の認知およびそれに対する主観的注意に関連して活動を示すとヒト脳の巨視的神経回路を明らかにすることが本研究の目的である。右利き若年者正常男性7名を対象とし、局所脳血流量をポジトロンCT装置を用いて計測した。課題遂行中は画面中央に表示した固視点を常に見つめているように被験者に指示をした。まずサンプル刺激として白黒のWalshパターンを固視点の両側に固視点から12.5度離れた位置に250msec呈示した。1000から4000secの遅延期間後、テスト刺激として白青のパターンを同じ位置に250msec呈示し、500から1500msecのインターバル後同じシークエンスを繰り返した。右注意課題では右視野に呈示されたサンプル刺激とテスト刺激が同一のパターンであれば右手のボタンを押して合図をするように指示をした。左注意課題では左視野に呈示されたパターンで同じことを行わせた。コントロール課題ではサンプル課題2回呈示につき一回ボタンを押すように指示をした。PET画像より局所脳血流画像を計算し、コンピュータ化脳図譜システムを利用して局所脳血流画像を解剖学的に標準化したのち、各注意課題引くコントロール課題の差分画像を作製、有意な変化を同定した。右注意課題では右半球前頭前野など17の領域に、左注意課題では左半球前頭前野など16の領域に有意な活動を認めた。左半球の下側頭溝内、右半球の頭頂間溝内に双方の課題で有意な活動を示す領域が認められた。本研究では、どちらの半球の一次視覚野に入ったパターン刺激でも遅延見本課題を遂行するときに左半球の下側頭溝領野が視覚情報処理系として機能するという半球機能差の存在が明らかになった。また右半球の頭頂間溝皮質内の領域はposterior attentional systemとして、辺縁視野への注意機構に関連することが示唆された。
ポジトロンCTを用いた短期記憶関連脳機能地図の作成

川島隆太

1995年～ 1995年

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本年度の研究では、短期記憶をコントロールする“central executive"機能が脳のどこかの領野にあるのを明らかにした。 9名の右利き男性被験者を対象とし、局所脳血流量をPET装置および酸素15で標識した水を用いて測定した。被験者はPETによる計測の最中に次の2つ課題を行った。1)角度DMS課題:被験者に頭部固定型ディスプレー(HMD)を装着させた。円の次に呈示される線分の角度を記憶し、同じ角度の線分が呈示された場合に右手で合図するよう指示した。2)コントロール課題:角度DMS課題と同じ視覚刺激を用いた。被験者には円が呈示されたときに右手で合図をするように指示した。各被験者の脳血流画像は、コンピュータ化脳図譜システムを利用して、解剖学的標準化した。その後、角度DMS課題引くコントロール課題の差分画像を作成し、有意(p<0.001)に活動を示した領野を特定した。角度DMS課題で活動を示した領野は、左半球の捕捉運動野、Precuneus、島皮質、下部後頭葉と、右半球の頭頂間溝、前頭前野に3ケ所、後頭葉に2ケ所、中側頭回に認められた。右半球前頭前野は他のモダリティーを使った短期記憶課題でも賦活されることが昨年度の研究で明らかにされており、この領野はmulti-modal areaであり、短期記憶に関するcentral executive機能又はcontrol機能を持つ領野である可能性が示唆された。
ポジトロンCTによる運動課題遂行中のヒト脳機能地図の作成

川島隆太

1994年～ 1994年

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上肢の運動に関連して働く、ヒト脳の巨視的な神経回路の解明を行うことが本研究の目的である。2組各10名の正常右利き男性被験者を対象とした。10名の被験者は自発的指運動および自発的上腕運動施行中に、他の10名の被験者は光刺激に基づく指運動施行中に局所脳血流量を測定した。自発的運動課題では、被験者は1秒に約1回、右手親指と人さし指を付ける運動、または上腕の筋肉を動かす運動を行った。光刺激に基づく運動では、被験者はまず、被験者の目の前に置かれた1個の発光ダイオードが赤く光ったら右手親指を、それが緑に光ったら人さし指を曲げる運動を行った。次に、赤く光ったなら同じように親指を曲げるが、緑なら何もしない運動を行わせた。いずれもコントロール課題は開眼安静状態であった。局所脳血流量はポジトロンCT装置を用いて測定した。脳血流画像はコンピュータ化脳図譜システムにて、3次元的に標準脳の形に変換後、各課題引くコントロールの差分画像を作成した。各組の各課題ごとに統計学的に有意に活動を示した領野を特定した。右指と右上腕の運動を支配する領野が左半球一次運動野の中にそれぞれ2ケ所ずつ存在すること、右腕の自発運動には運動の部位には関わりなく左半球の補足運動野と頭頂連合野の活動が重要であること、光刺激の意味を判断し適切な右手で運動を発現させるためには左半球の帯状回の活動が重要であること、運動を発現させないという意志発動は右半球の前頭前野が重要であること、が世界で初めて明らかにされた。
ポジトロンCTを用いた短期記憶関脳機能地図の作成

川島降太

1994年～ 1994年

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短期記憶の情報処理に関する、ヒト脳における巨視的な神経回路の解明を行うことが本研究の目的である。2組各10名の右利き男性被験者を対象とした。10名の被験者は"短期記憶関連なし課題"施行中に、他の10名の被験者は"短期記憶関連あり課題"施行中に局所脳血流量を測定した。被験者は、両眼で単色光を凝視し、両耳より単音を聴取し、左手の人差し指の指先で振動を同時に触知することが求められた。記憶関連なし課題では、3種類の感覚刺激の中で1種類の刺激の強度(視覚:明るさ、聴覚:周波数、触覚:振動数)を連続的に変化させた。被験者には、感覚刺激の強さが強く変化したときは何もせず、弱く変化したときは右手のボタンを押すよう指示した。記憶関連あり課題では、感覚刺激を連続的に変化させるのではなく、あいだに一定の低いレベルの刺激を与えた。被験者は感覚刺激の強さの弁別を行うために、この低いレベルの刺激が与えられている間に、前回の感覚刺激の強さを記憶していなくてはならない。局所脳血流量はポジトロンCT装置を用いて測定した。脳血流画像はコンピュータ化脳図譜システムにて、3次元的に標準脳の形に変換後、各課題引くコントロールの差分画像を作成した。各組の各感覚刺激課題ごとに統計学的に有意に活動を示した領野を特定した。短期記憶関連あり課題施行中に共通して活動を示した領野の中で、右半球の中前頭回の2つの領野は、短期記憶なし課題施行中には活動を示さなかった。2つの課題はそれぞれ、感覚入力、知覚、感覚情報の弁別運動出力に関しては、同一であり、唯一の違いは短期記憶の保持が課題遂行に必要か否かである。したがってこの2つの右半球の領野の活動は、感覚モダリティーによらない、短期記憶の保持に重要な関連があることが世界で始めて示唆された。

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高齢者と学習障害の脳機能改善コホート研究

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高齢者と学習障害の脳機能改善コホート研究
コミュニケーション機能の発達における「身体性」の役割

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コミュニケーション機能の発達における「身体性」の役割
脳機能イメージング

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脳機能イメージング
脳機能イメージングほか

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脳機能イメージングほか
知財創造経費

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知財創造経費