Details of the Researcher

PHOTO

Ryuta Kawashima
Section
Institute of Development, Aging and Cancer
Job title
Professor
Degree

  • 医学博士（東北大学）

Research History 4

  • 2001/05 - Present
    東北大学　教授

  • 1998/06 - 2001/04
    東北大学　講師

  • 1993/07 - 1998/05
    東北大学　助手

  • 1991/07 - 1993/04
    カロリンスカ研究所

Education 2

  • Tohoku University　Graduate School, Division of Medicine

    - 1989/03

  • Tohoku University　Faculty of Medicine

    - 1985/03

Research Interests 6

  • 脳機能イメージング

  • 脳機能マッピング

  • ２光子顕微鏡

  • 多チャンネルEEG

  • NIRS

  • functional MRI

Research Areas 1

  • Life sciences / Neuroscience - general /

Awards 13

  1. 河北文化賞

    2013/01/17　河北文化事業団

  2. 井上春成賞

    2009/07/15　井上春成賞委員会

  3. 平成21年度科学技術分野の文部科学大臣表彰科学技術賞

    2009/04/14　文部科学省

  4. 平成20年度「情報通信月間」総務大臣表彰

    2008/06/01　総務省

  5. 日本ＰＲ（パーソン・オブザイヤー）大賞

    2007/01　日本ＰＲ協会

  6. 科学技術への顕著な貢献in2006

    2006/12　文部科学省科学技術政策研究所

  7. トレンド大賞

    2006/12　（株）小学館

  8. 流行語大賞

    2006/12　（株）ユーキャン

  9. Hiramek-ist Award 2006

    2006/11　（株）リプトン

  10. 日本ゲーム大賞

    2006/10　一般社団法人コンピュータエンターテインメント協会

  11. Top 50 Innovators in New Media for 2006

    2006/09　Producers Guild of America New Media Coucil

  12. 日本神経回路学会論文賞

    2004/09　日本神経回路学会

  13. 第34回日本核医学会賞

    1996/10　日本核医学会

Show all ︎Show 5

Papers 603

  1. The neural basis of coping strategies for boredom and their association with creativity

    Sugiko Hanawa, Takayuki Nozawa, Motoaki Sugiura, Rui Nouchi, Ryoichi Yokoyama, Benjamin Thyreau, Yuka Kotozaki, Tsuyoshi Araki, Ryuta Kawashima

    Thinking Skills and Creativity　101794-101794　2025/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.tsc.2025.101794 　

    ISSN： 1871-1871

  2. Rising-frequency chirp stimuli effectively enhance the amplitude and shorten the latency of 40-hz auditory steady-state response

    Shunsuke Takai, Takashi Morimoto, Akitake Kanno, Tetsuaki Kawase, Jun Suzuki, Nobukatsu Nakasato, Ryuta Kawashima, Yukio Katori

    International Journal of Audiology　1-8　2024/12/10

    Publisher: Informa UK Limited

    DOI： 10.1080/14992027.2024.2430765 　

    ISSN： 1499-2027

    eISSN： 1708-8186

  3. Self-Choice Emotion Regulation Enhances Stress Reduction: Neural Basis of Self-Choice Emotion Regulation

    Nozomi Imajo, Yutaka Matsuzaki, Akiko Kobayashi, Kohei Sakaki, Rui Nouchi, Ryuta Kawashima

    Brain Sciences　14　(11)　1077-1077　2024/10/28

    Publisher: MDPI AG

    DOI： 10.3390/brainsci14111077 　

    eISSN： 2076-3425

    More details Close

    Background/Objectives: Opting to perform emotion regulation when facing high-arousal stimuli enhances the reduction in negative emotions. Previous research has indicated that self-choice, that is, personally choosing from multiple alternatives, can improve performance. However, it is unclear whether the emotion regulation strategy chosen among multiple alternatives in daily life enhances stress reduction compared to a forced strategy. This study aimed to reveal the effects of self-choice emotion regulation and its underlying neural basis. Methods: Participants were 40 healthy adults who met the inclusion criteria; they performed self-choice emotion regulation, forced emotion regulation, and no emotion regulation (the control condition) while their brain activity was captured using a functional magnetic resonance imaging scanner. First, the participants were shown a stressful scenario. Secondly, they rated the stress they experienced. Thirdly, they performed self-choice or forced emotion regulation or did nothing. Finally, participants rated their stress level again. Results: Self-choice emotion regulation reduced stress better than forced-choice emotion regulation. The stress reduction was associated with decreases in the activation of the left opercular part of the inferior frontal gyrus. Conclusions: Self-choice can improve emotion regulation, and this effect is likely mediated by the neural efficiency of the left inferior frontal gyrus.

  4. Highly demarcated structural alterations in the brain and impaired social incentive learning in Tbx1 heterozygous mice. International-journal

    Takeshi Hiramoto, Akira Sumiyoshi, Risa Kato, Takahira Yamauchi, Takeshi Takano, Gina Kang, Marisa Esparza, Bailey Matsumura, Lucas J Stevens, Yukiko J Hiroi, Takaki Tanifuji, Rie Ryoke, Hiroi Nonaka, Akihiro Machida, Kensaku Nomoto, Kazutaka Mogi, Takefumi Kikusui, Ryuta Kawashima, Noboru Hiroi

    Molecular psychiatry　2024/10/27

    DOI： 10.1038/s41380-024-02797-x 　

    More details Close

    Copy number variants (CNVs) are robustly associated with psychiatric disorders and changes in brain structures. However, because CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations in the brains of 22q11.2 CNV carriers have been identified in humans and mouse models, it is unknown how each gene encoded in the 22q11.2 region contributes to structural alterations, associated mental illnesses, and their dimensions. Our previous studies identified Tbx1, a T-box family transcription factor encoded in the 22q11.2 CNV, as a driver gene for social interaction and communication, spatial and working memory, and cognitive flexibility. However, it remains unclear how TBX1 impacts the volumes of various brain regions and their functionally linked behavioral dimensions. In this study, we used volumetric magnetic resonance imaging analysis to comprehensively evaluate brain region volumes and behavioral alterations relevant to affected structures in congenic Tbx1 heterozygous mice. Our data showed that the volumes of the anterior and posterior portions of the amygdaloid complex and its surrounding cortical regions were most robustly reduced in Tbx1 heterozygous mice. In an amygdala-dependent task, Tbx1 heterozygous mice were impaired in their ability to learn the incentive value of a social partner. The volumes of the primary and secondary auditory cortexes were increased, and acoustic, but not non-acoustic, sensorimotor gating was impaired in Tbx1 heterozygous mice. Our findings identify the brain's regional volume alterations and their relevant behavioral dimensions associated with Tbx1 heterozygosity.

  5. Preventive effect of one-session brief focused attention meditation on state fatigue: Resting state functional magnetic resonance imaging study

    Noriki Yamaya, Teruo Hashimoto, Shigeyuki Ikeda, Denilson Brilliant T, Masayuki Tsujimoto, Seishu Nakagawa, Ryuta Kawashima

    NeuroImage　120709-120709　2024/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.neuroimage.2024.120709 　

    ISSN： 1053-8119

  6. Perceiving humanness across ages: neural correlates and behavioral patterns

    Toshiki Saito, Rui Nouchi, Ryo Ishibashi, Kosuke Motoki, Yutaka Matsuzaki, Akiko Kobayashi, Motoaki Sugiura, Ryuta Kawashima

    Frontiers in Psychology　15　2024/04/04

    Publisher: Frontiers Media SA

    DOI： 10.3389/fpsyg.2024.1361588 　

    eISSN： 1664-1078

    More details Close

    Humanness perception, which attributes fundamental and unique human characteristics to other objects or people, has significant consequences for people’s interactions. Notably, the failure to perceive humanness in older adults can lead to prejudice. This study investigates the effect of a target’s age on humanness perception in terms of two dimensions: agency (the ability to act and do) and experience (the ability to feel and sense). We also examined brain activity using a magnetic resonance imaging (MRI) scanner in order to understand the underlying neural mechanisms. Healthy university students viewed the facial images of older and younger individuals and judged the humanness of each individual in terms of agency and experience while inside the MRI scanner. The results indicated that older adults were rated higher on experience, and no difference was found in ratings for agency between younger and older face images. Analysis of brain imaging data indicated that positive functional connectivity between the ventral and dorsal regions of the medial prefrontal cortex (mPFC) was greater when judging the humanness of younger faces than older faces. We also found that the negative functional connectivity between the left inferior frontal gyrus and postcentral gyrus was greater when judging the humanness of older faces as compared to that of younger faces. Although the current study did not show distinct brain activities related to humanness perception, it suggests the possibility that different brain connectivities are related to humanness perception regarding targets belonging to different age groups.

  7. Predicting conversational satisfaction of face-to-face conversation through interpersonal similarity in resting-state functional connectivity. International-journal

    Shigeyuki Ikeda, Hyeonjeong Jeong, Yukako Sasaki, Kohei Sakaki, Shohei Yamazaki, Takayuki Nozawa, Ryuta Kawashima

    Scientific reports　14　(1)　6015-6015　2024/03/12

    DOI： 10.1038/s41598-024-56718-7 　

    More details Close

    When conversing with an unacquainted person, if it goes well, we can obtain much satisfaction (referred to as conversational satisfaction). Can we predict how satisfied dyads will be with face-to-face conversation? To this end, we employed interpersonal similarity in whole-brain resting-state functional connectivity (RSFC), measured using functional magnetic resonance imaging before dyadic conversation. We investigated whether conversational satisfaction could be predicted from interpersonal similarity in RSFC using multivariate pattern analysis. Consequently, prediction was successful, suggesting that interpersonal similarity in RSFC is an effective neural biomarker predicting how much face-to-face conversation goes well. Furthermore, regression coefficients from predictive models suggest that both interpersonal similarity and dissimilarity contribute to good interpersonal relationships in terms of brain activity. The present study provides the potential of an interpersonal similarity approach using RSFC for understanding the foundations of human relationships and new neuroscientific insight into whether success in human interactions is predetermined.

  8. Enhanced memory and hippocampal connectivity in humans 2 days after brief resistance exercise. International-journal

    Teruo Hashimoto, Rikimasa Hotta, Ryuta Kawashima

    Brain and behavior　14　(2)　e3436　2024/02

    DOI： 10.1002/brb3.3436 　

    More details Close

    INTRODUCTION: Exercise has significant health benefits and can enhance learning. A single bout of high-intensity resistance training may be sufficient to improve memory. This study aimed to assess memory enhancement by a single bout of high-intensity resistance training and to examine the neural underpinnings using resting-state functional magnetic resonance imaging (MRI). METHODS: Sixty young adults (34 men and 26 women), divided into the training and control groups, participated. The first session included verbal memory recall tests (cued- and free-recall), resting-state functional MRI (rs-fMRI), and a single-bout high-intensity resistance training for the training group. Two days later, they underwent post-intervention memory tests and rs-fMRI. The study design was 2 groups × 2 sessions for memory tests, and within training group comparisons for rs-fMRI. RESULTS: Compared to the control group without resistance training, the training group showed higher cued-recall performance 2 days after the brief resistance training (training: +0.27, control: -0.13, interaction: p = .01), and their free-recall scores were associated with enhanced left posterior hippocampal connectivity (r = .64, p < .001). CONCLUSIONS: These results suggest that brief high-intensity resistance exercise/strength training could enhance memory without repeated exercising. The quick effect of resistance training on memory and hippocampal connectivity could be revealed. A focused and one-shot exercise may be sufficient to enhance memory performance and neural plasticity in a few days.

  9. Effects of pain associated with orthodontic tooth movement on tactile sensation of periodontal ligaments. International-journal

    Eriya Shimada, Hiroyasu Kanetaka, Hiroki Hihara, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato, Kaoru Igarashi

    Clinical oral investigations　28　(1)　36-36　2023/12/26

    DOI： 10.1007/s00784-023-05469-2 　

    More details Close

    OBJECTIVES: Pain associated with orthodontic tooth movement reportedly reduces periodontal ligament tactile sensation. However, the mechanism associated with the central nervous system remains unclear. This study was conducted by measuring somatosensory evoked magnetic fields (SEFs) during mechanical stimulation of teeth as they were being moved by separator elastics. Findings clarified the effects of pain on periodontal ligament tactile sensation during orthodontic tooth movement. MATERIALS AND METHODS: Using magnetoencephalography, SEFs were measured during the application of mechanical stimuli to the mandibular right first molars of 23 right-handed healthy participants (0 h). Separator elastics were subsequently inserted into the mesial and distal interdental portions of the mandibular right first molars. The same mechanical stimuli were applied again 24 h later while the SEFs were measured (24 h). After each SEF measurements, pain was also evaluated using the Visual Analog Scale (VAS). RESULTS: The VAS values were significantly higher at 24 h than at 0 h (p < 0.05). No significant difference in the peak latencies was found between those obtained at 0 h and 24 h, but the intensities around 40.0 ms in the contralateral hemisphere were significantly lower at 24 h than at 0 h (p < 0.01). CONCLUSIONS: Pain associated with orthodontic tooth movement might suppress periodontal ligament tactile sensation in the primary somatosensory cortex. CLINICAL RELEVANCE: Pain associated with orthodontic tooth movement might affect periodontal ligament sensation, consequently causing discomfort during occlusion.

  10. Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial. International-journal

    Rui Nouchi, Natasha Y S Kawata, Toshiki Saito, Haruka Nouchi, Ryuta Kawashima

    Nutrients　15　(21)　2023/10/30

    DOI： 10.3390/nu15214608 　

    More details Close

    BACKGROUND: Cognitive functions decline with age. Declined cognitive functions negatively affect daily behaviors. Previous studies showed the positive effect of spices and herbs on cognition. In this study, we investigated the positive impact of wasabi, which is a traditional Japanese spice, on cognitive functions. The main bioactive compound of wasabi is 6-MSITC (6 methylsulfinyl hexyl isothiocyanate), which has anti-oxidant and anti-inflammatory functions. Anti-oxidants and anti-inflammatories have an important role in cognitive health. Therefore, 6-MSITC is expected to have positive effects on cognitive function. Previous studies showed the beneficial effects on cognitive functions in middle-aged adults. However, it is unclear that 6-MSITC has a positive effect on cognitive functions in healthy older adults aged 60 years and over. Here, we investigated whether 12 weeks' 6-MSITC intervention enhances cognitive performance in older adults using a double-blinded randomized controlled trial (RCT). METHODS: Seventy-two older adults were randomly assigned to 6-MSITC or placebo groups. Participants were asked to take a supplement (6-MSITC or a placebo) for 12 weeks. We checked a wide range of cognitive performances (e.g., executive function, episodic memory, processing speed, working memory, and attention) at the pre- and post-intervention periods. RESULTS: The 6-MSITC group showed a significant improvement in working and episodic memory performances compared to the placebo group. However, we did not find any significant improvements in other cognitive domains. DISCUSSION: This study firstly demonstrates scientific evidence that 6-MSITC may enhance working memory and episodic memory in older adults. We discuss the potential mechanism for improving cognitive functions after 6-MSITC intake.

  11. Neural representation of a one-week delay in remembering information after production and self-generated elaboration encoding strategy

    Ryo Nakamura, Rui Nouchi, Ayano Yagi, Noriki Yamaya, Masaya Ota, Minami Ishigooka, Ryuta Kawashima

    Acta Psychologica　240　104051-104051　2023/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.actpsy.2023.104051 　

    ISSN： 0001-6918

  12. Language MEG predicts postoperative verbal memory change in left mesial temporal lobe epilepsy

    Ryuzaburo Kochi, Shin-ichiro Osawa, Kazutaka Jin, Makoto Ishida, Akitake Kanno, Masaki Iwasaki, Kyoko Suzuki, Ryuta Kawashima, Teiji Tominaga, Nobukazu Nakasato

    Clinical Neurophysiology　2023/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.clinph.2023.09.010 　

    ISSN： 1388-2457

  13. Right amygdala and caudate activation patterns predict implicit attitudes toward people with autism spectrum disorders and physical disabilities, respectively

    Susumu Yokota, Teruo Hashimoto, Yutaka Matsuzaki, Shigeyuki Ikeda, Ryuta Kawashima

    Cognitive, Affective, &amp; Behavioral Neuroscience　2023/09/19

    Publisher: Springer Science and Business Media LLC

    DOI： 10.3758/s13415-023-01126-z 　

    ISSN： 1530-7026

    eISSN： 1531-135X

  14. Effects of adult education on cognitive function and risk of dementia in older adults: a longitudinal analysis Peer-reviewed

    Takeuchi H, Kawashima R

    Frontiers in Aging Neuroscience　15　2023/08

    DOI： 10.3389/fnagi.2023.1212623 　

  15. Social-coalitional trait is related to coping capacity with mortality threat: association with leadership and a reduced parietal response to mortality salience

    Kanan Hirano, Kentaro Oba, Toshiki Saito, Ryuta Kawashima, Motoaki Sugiura

    Frontiers in Behavioral Neuroscience　17　2023/07/13

    Publisher: Frontiers Media SA

    DOI： 10.3389/fnbeh.2023.1188878 　

    eISSN： 1662-5153

    More details Close

    Introduction Coping with mortality threat, a psychological threat unique to humans and distinct from general emotional distress, is traditionally characterized by immediate suppression and prolonged worldview defense within the framework of the influential terror management theory (TMT). Views regarding the personality-trait concepts for this coping capacity diverge: some favor a broad definition based on general psychological attitudes (e.g., hardiness), while others prefer a narrow definition linked to interpersonal attitudes related to social coalition (e.g., attachment style and self-transcendence). Methods Using functional MRI, we presented healthy older participants with death-related words and explored correlations between the neural responses to mortality threat and the factor scores of the Power to Live questionnaire, which measures eight resilience-related psychobehavioral traits. Results We observed a significant association between the factor score and a neural response only for leadership; individuals with a high leadership score exhibited reduced neural response to mortality salience in the right inferior parietal lobule. Discussion Within the TMT framework, our findings align with the concept of the immediate suppression of death-thought accessibility associated with a secure attachment style, a trait conceptually linked to leadership. These findings highlight the unique role for the narrowly defined social-coalitional trait during the immediate stage of the coping process with mortality salience, in contrast to the broadly defined resilience-related personality traits associated with a prolonged worldview defense process. The deterioration of this coping process could constitute a distinct aspect of psychopathology, separate from dysfunction in general emotion regulation.

  16. fMRI reveals the dynamic interface between explicit and implicit knowledge recruited during elicited imitation task Peer-reviewed

    Yuichi Suzuki†, Hyeonjeong Jeong†, Cui Haining, Kiyo Okamoto, Ryuta Kawashima, Motoaki Sugiura

    Research Methods in Applied Linguistics　2　(2)　100051　2023/06/01

    DOI： 10.1016/j.rmal.2023.100051 　

  17. Brain activation and functional connectivity of reappraisal and acceptance for anxious events

    Masayuki Tsujimoto, Yutaka Matsuzaki, Noriki Yamaya, Ryuta Kawashima

    eneuro　10　(6)　ENEURO.0033-23.2023　2023/05/23

    Publisher: Society for Neuroscience

    DOI： 10.1523/eneuro.0033-23.2023 　

    eISSN： 2373-2822

    More details Close

    Despite the significant health consequences of anxiety, the neural basis of regulation for personal anxious events is not well understood. We compared brain activity and functional connectivity during cognitive emotion regulation strategies (reappraisal and acceptance) for personal anxious events. Functional MRI data were obtained while 35 college students were thinking about (the control condition), reappraising, or accepting their own anxiety-provoking situations. Although reappraisal and acceptance decreased anxiety, no statistically significant differences were observed in the brain activation levels between cognitive emotion regulation strategies and the control condition. However, acceptance decreased activation in the posterior cingulate cortex and precuneus more than reappraisal. Moreover, functional connectivity with the amygdala and ventral anterior insula distinguished the emotion regulation strategies for anxiety. Reappraisal showed stronger negative functional connectivity with the amygdala and cognitive control regions than other strategies. In addition, reappraisal had negative functional coupling between the ventral anterior insula and temporal pole compared with acceptance. In contrast, acceptance showed stronger positive functional coupling between the ventral anterior insula and precentral and postcentral gyrus compared with the control condition. Our findings contribute to the understanding of emotion regulation processes by revealing the brain activity and functional connectivity patterns in reappraisal and acceptance for personal anxious events. Significance statement This study is the first to reveal the differences in brain activity and functional connectivity between reappraisal and acceptance for individual anxious events. We found that reappraisal strengthened the negative functional coupling between the cognitive control areas and emotion-processing regions. In contrast, acceptance was characterized by a reduction in the self-reflection process and strengthened the functional coupling between emotion-processing regions and self-reflective and emotion recognition areas. These results contribute to a better understanding of emotion regulation processes by providing the differences in relationships of activation in self-reflection, cognitive control, and emotion-processing regions between reappraisal and acceptance for personal anxious events. These findings may help discover interventions for mitigating the negative effects of anxiety.

  18. Possibility of additive effects by the presentation of visual information related to distractor sounds on the contra-sound effects of the N100m responses. International-journal

    Shunsuke Takai, Akitake Kanno, Tetsuaki Kawase, Masayuki Shirakura, Jun Suzuki, Nobukatsu Nakasato, Ryuta Kawashima, Yukio Katori

    Hearing research　434　108778-108778　2023/04/23

    DOI： 10.1016/j.heares.2023.108778 　

    More details Close

    Auditory-evoked responses can be affected by different types of contralateral sounds or by attention modulation. The present study examined the additive effects of presenting visual information about contralateral sounds as distractions during dichotic listening tasks on the contralateral effects of N100m responses in the auditory-evoked cortex in 16 subjects (12 males and 4 females). In magnetoencephalography, a tone-burst of 500 ms duration at a frequency of 1000 Hz was played to the left ear at a level of 70 dB as a stimulus to elicit the N100m response, and a movie clip was used as a distractor stimulus under audio-only, visual-only, and audio-visual conditions. Subjects were instructed to pay attention to the left ear and press the response button each time they heard a tone-burst stimulus in their left ear. The results suggest that the presentation of visual information related to the contralateral sound, which worked as a distractor, significantly suppressed the amplitude of the N100m response compared with only the contralateral sound condition. In contrast, the presentation of visual information related to contralateral sound did not affect the latency of the N100m response. These results suggest that the integration of contralateral sounds and related movies may have resulted in a more perceptually loaded stimulus and reduced the intensity of attention to tone-bursts. Our findings suggest that selective attention and saliency mechanisms may have cross-modal effects on other modes of perception.

  19. Motivational decline and proactive response under thermal environmental stress are related to emotion- and problem-focused coping, respectively: Questionnaire construction and fMRI study

    Kelssy Hitomi dos Santos Kawata, Kanan Hirano, Yumi Hamamoto, Hajime Oi, Akitake Kanno, Ryuta Kawashima, Motoaki Sugiura

    Frontiers in Behavioral Neuroscience　17　2023/04/12

    Publisher: Frontiers Media SA

    DOI： 10.3389/fnbeh.2023.1143450 　

    eISSN： 1662-5153

    More details Close

    Despite the diversity of human behavioral and psychological responses to environmental thermal stress, the major dimensions of these responses have not been formulated. Accordingly, the relevance of these responses to a framework of coping with stress (i.e., emotion- and problem-focused) and the neural correlates are unexplored. In this study, we first developed a multidimensional inventory for such responses using social surveys and a factor analysis, and then examined the neural correlates of each dimension using a functional magnetic resonance imaging; we manipulated the ambient temperature between uncomfortably hot and cold, and the correlations between the inventory factor scores and discomfort-related neural responses were examined. We identified three factors to construct the inventory: motivational decline, proactive response, and an active behavior, which appeared to reflect inefficient emotion-focused coping, efficient problem-focused coping, and positive appreciation of extreme environmental temperatures, respectively, under environmental thermal stress. Motivational decline score was positively associated with common neural response to thermal stress in the frontal and temporoparietal regions, implicated in emotion regulation, while proactive response score negatively with the neural responses related to subjective discomfort in the medial and lateral parietal cortices, implicated in problem-solving. We thus demonstrated that two of three major dimensions of individual variation in response to and coping with environmental thermal stress conform to an influential two-dimensional framework of stress coping. The current three-dimensional model may expand the frontiers of meteorological human science in both basic and application domains.

  20. A consensus protocol for functional connectivity analysis in the rat brain. International-journal

    Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A Barrière, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M Cardoso, Marina Célestine, Jorge E Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvořáková, Claudia Falfán-Melgoza, Francisca F Fernandes, Caitlin F Fowler, Antonio Fuentes-Ibañez, Clément M Garin, Eveline Gelderman, Carla E M Golden, Chao C G Guo, Marloes J A G Henckens, Lauren A Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y Liu, Alejandra López-Castro, Xavier López-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M P Naessens, Laura J Nava-Gomez, Hiroi Nonaka, Juan J Ortiz, Jaakko Paasonen, Lore M Peeters, Mickaël Pereira, Pablo D Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Pérez, Gabriele Russo, Tobias J Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G Sanganahalli, Aileen Schroeter, Bhedita J Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A B Smith, Corrie Smith, Filip Sobczak, Petteri J Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E Torres-García, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T B van Hout, Roberta Vertullo, Benjamin Vidal, Roël M Vrooman, Victora X Wang, Isabel Wank, David J G Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P Auer, Emmanuel L Barbier, Jürgen Baudewig, Christian F Beckmann, Nicolau Beckmann, Guillaume J P C Becq, Erwin L A Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F Coolen, Jeffrey W Dalley, Marc Dhenain, Rick M Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W Feindel, Gianluigi Forloni, Jérémie Fouquet, Eduardo A Garza-Villarreal, Natalia Gass, Jeffrey C Glennon, Alessandro Gozzi, Olli Gröhn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R Homberg, Danielle J Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D Keilholz, Georgios A Keliris, Clare Kelly, Christian Kerskens, Jibran Y Khokhar, Peter C Kind, Jean-Baptiste Langlois, Jason P Lerch, Monica A López-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B Mars, Gerardo Marsella, Edoardo Micotti, Emma Muñoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M Otte, Patricia Pais-Roldán, Wen-Ju Pan, Roberto A Prado-Alcalá, Gina L Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J Sawiak, Tom W J Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J Thompson, Sally M Till, Nick Todd, Annemie Van Der Linden, Annette van der Toorn, Geralda A F van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B Zhang, Luc Zimmer, Gabriel A Devenyi, M Mallar Chakravarty, Andreas Hess

    Nature neuroscience　26　(4)　673-681　2023/04

    DOI： 10.1038/s41593-023-01286-8 　

    More details Close

    Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

  21. The Effect of Cognitive Training with Neurofeedback on Cognitive Function in Healthy Adults: A Systematic Review and Meta-Analysis

    Yutaka Matsuzaki, Rui Nouchi, Kohei Sakaki, Jérôme Dinet, Ryuta Kawashima

    Healthcare　11　(6)　843-843　2023/03/13

    Publisher: MDPI AG

    DOI： 10.3390/healthcare11060843 　

    eISSN： 2227-9032

    More details Close

    Background: Cognitive training aims to improve cognitive function through cognitive tasks or training games. Neurofeedback is a technique to monitor brain signals with either visual or auditory feedback. Previous studies suggest that a combination of cognitive training and neurofeedback has a superior effect on cognitive functions compared with cognitive training alone. However, no systematic reviews and meta-analyses of the benefits of cognitive training with neurofeedback (CTNF) exist. The purpose of this study was to examine the beneficial effects of CTNF in healthy adults using a systematic review and multilevel meta-analysis. Methods: PubMed, Scopus, PsychoINFO, and MEDLINE were searched for research papers reporting the results of interventions using CTNF. Results: After an initial screening of 234 records, three studies using near-infrared spectroscopy (NIRS) and one study using electroencephalography were extracted from the database. We performed a multi-level meta-analysis with three NIRS studies including 166 participants (mean ages ranged from 21.43 to 65.96 years). A multi-level meta-analysis revealed that CTNF has a beneficial effect on the episodic, long-term, and working memory domains. Conclusions: Although three studies were included in the systematic review and meta-analysis, our results indicate that CTNF using NIRS would lead to improvements in memory functioning.

  22. Automatic adaptive emotion regulation is associated with lower emotion-related activation in the frontoparietal cortex and other cortical regions with multi-componential organization

    Motoaki Sugiura, Yoko Katayori, Tomohiko Muratsubaki, Miyuki Shiratori, Sugiko Hanawa, Keyvan Kashkouli Nejad, Daisaku Tamura, Ryuta Kawashima, Shin Fukudo

    Frontiers in Behavioral Neuroscience　17　2023/03/06

    Publisher: Frontiers Media SA

    DOI： 10.3389/fnbeh.2023.1059158 　

    eISSN： 1662-5153

    More details Close

    Although some researchers consider automatic adaptive emotion regulation to be an automatized strategy whereas others consider it to be implicit disengagement of deliberative process, to date, its neural correlates have been poorly investigated. In addition, the valence specificity of automatic adaptive emotion regulation and levels of activation relative to the neutral condition are controversial; the former is relevant to the attribution of resilient emotion regulation to positivity bias or emotional stability, and the latter to determining whether regulation is based on emotion-specific or emotion-non-specific processes. In this functional magnetic resonance imaging (fMRI) study, we presented positive and negative emotional pictures to healthy young participants and investigated the neural correlates of automatic adaptive emotion regulation in spontaneous emotional response. A significant negative trait effect (i.e., regression coefficient) on activation was identified both for positive and negative emotional responses in various cortical regions. A cluster analysis identified three clusters among these regions based on the valence specificity of the trait effect and level of activation relative to neutral stimuli. Cluster 1 included regions in the sensorimotor cortex characterized by negative emotion-specific decreases in activation relative to neutral stimuli in adaptive individuals. Cluster 2 included several cortical regions including the bilateral dorsal executive network, anterior cingulate, and inferior frontal gyrus, which were characterized by valence-independent decreases in activation in adaptive individuals. Cluster 3 included the bilateral ventrolateral and dorsomedial prefrontal cortices, right insula, and other posterior regions, which were characterized by increased activation for negative stimuli in non-adaptive individuals. These findings support the assumption that automatic adaptive emotion regulation involves the implicit disengagement of deliberative process and suggest the relevance of different cortical networks to the potential emotion- and valence-specificity of adaptive regulation.

  23. Effects of television viewing on brain structures and risk of dementia in the elderly: longitudinal analyses Invited Peer-reviewed

    Takeuchi H, Kawashima R

    Frontiers in Neuroscience　17　article-984919　2023/03

    DOI： 10.3389/fnins.2023.984919. 　

  24. Sincere praise and flattery: reward value and association with the praise-seeking trait

    Shotaro Fujiwara, Ryo Ishibashi, Azumi Tanabe-Ishibashi, Ryuta Kawashima, Motoaki Sugiura

    Frontiers in Human Neuroscience　17　2023/02/15

    Publisher: Frontiers Media SA

    DOI： 10.3389/fnhum.2023.985047 　

    eISSN： 1662-5161

    More details Close

    Sincere praise reliably conveys positive or negative feedback, while flattery always conveys positive but unreliable feedback. These two praise types have not been compared in terms of communication effectiveness and individual preferences using neuroimaging. Through functional magnetic resonance imaging, we measured brain activity when healthy young participants received sincere praise or flattery after performing a visual search task. Higher activation was observed in the right nucleus accumbens during sincere praise than during flattery, and praise reliability correlated with posterior cingulate cortex activity, implying a rewarding effect of sincere praise. In line with this, sincere praise uniquely activated several cortical areas potentially involved in concern regarding others’ evaluations. A high praise-seeking tendency was associated with lower activation of the inferior parietal sulcus during sincere praise compared to flattery after poor task performance, potentially reflecting suppression of negative feedback to maintain self-esteem. In summary, the neural dynamics of the rewarding and socio-emotional effects of praise differed.

  25. Nutrients and Dementia: Prospective Study Invited Peer-reviewed

    Takeuchi H, Kawashima R

    Nutrients　15　(4)　article-842　2023/02

    DOI： 10.3390/nu15040842. 　

  26. Neural mechanisms of perceptual and affective body-image disturbance during own-body and ideal-body estimation

    Yumi Hamamoto, Shinsuke Suzuki, Kosuke Motoki, Kentaro Oba, Ryuta Kawashima, Motoaki Sugiura

    Behavioural Brain Research　114349-114349　2023/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.bbr.2023.114349 　

    ISSN： 0166-4328

  27. Acute Benefits of Acidified Milk Drinks with 10-g and 15-g Protein on Shifting and Updating Performances in Young Adults: A Randomized Controlled Trial. International-journal

    Rui Nouchi, Laurie T Butler, Daniel Lamport, Haruka Nouchi, Ryuta Kawashima

    Nutrients　15　(2)　2023/01/13

    DOI： 10.3390/nu15020431 　

    More details Close

    BACKGROUND: Accumulating evidence has shown that protein-rich milk drinks can rapidly improve cognitive performance. However, the optimum doses of milk protein that are needed to improve cognitive function remain to be investigated. OBJECTIVE: This study aimed to determine whether acidified milk drinks with 10-g and 15-g milk protein have acute benefits on key cognitive functions in healthy young adults. DESIGN: In this double-blinded randomized control trial, 66 young adults were randomly assigned to one of three groups (0-g, 10-g, and 15-g milk protein groups). Key cognitive functions (processing speed, inhibition, shifting, updating, and working memory capacity) were assessed before and 15 and 60 min after the drink intake. RESULTS: We found that the shifting performance improved at 15 min after intake of the acidified 10-g and 15-g milk protein drinks compared to intake of the 0-g milk protein drink, and this acute effect of the acidified 15-g milk protein drink lasted for 60 min. In addition, updating performance improved at 60 min after intake of the acidified 10-g and 15-g milk protein drinks compared to intake of the 0-g milk protein drink. CONCLUSION: Our findings suggest that the acidified 10-g and 15-g milk protein drinks have an acute benefit on shifting and updating performance in healthy young adults.

  28. Disappearance and Re-Emergence of Influenza during the COVID-19 Pandemic: Association with Infection Control Measures

    Hikaru Takeuchi, Ryuta Kawashima

    Viruses　15　(1)　223-223　2023/01/13

    Publisher: MDPI AG

    DOI： 10.3390/v15010223 　

    eISSN： 1999-4915

    More details Close

    During the coronavirus disease 2019 (COVID-19) pandemic, the influenza virus had a very low prevalence, and in many areas, outbreaks were almost non-existent. In this study, the associations between infection control measures taken for COVID-19 and the global disappearance of the influenza virus were investigated. The detection rate of influenza from baseline was investigated during four seasons (12 weeks from epidemiological week 49 in 2020 and 2021 and 12 weeks from epidemiological week 23 in 2020 and 2021) in each country participating in the surveillance system of the World Health Organization. Three measures of infection control: mask use ratio, social distancing index (an index of human mobility and physical distance obligations), and an index of stringency of measures taken by authorities were studied. In mid-2020, most countries analyzed had high levels of infection control measures, and in most countries, influenza was drastically reduced compared to previous years. Multiple regression analyses compared the study data with data from other seasons. There was an association between high mask use with low influenza detection in all three remaining seasons, an association between a low social distancing index (low mobility and more social contact obligations) with a low influenza detection rate in two seasons, and a marginal significant association of high stringency index with a low influenza detection rate(in 2020-end-seasons). These results support the notion that seasonal influenza is controllable through effective preventive measures, especially those of mask use and human social contact, and these measures should be recommended during future waves of novel influenza virus infection.

  29. Temporal Changes in the State Effect of Meditation on Response Inhibition Processes

    Noriki Yamaya, Shigeyuki Ikeda, Yuichi Hoshino, Hikaru Takeuchi, Ryuta Kawashima

    Mindfulness　2023/01/10

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12671-022-02064-6 　

    ISSN： 1868-8527

    eISSN： 1868-8535

    More details Close

    Abstract Objectives A single session of brief focused attention meditation (FAM) has a state effect, which temporarily enhances response inhibition processes. However, previous research has two unanswered questions: (i) How long does the state effect last? (ii) How does effort toward FAM relate to the resulting state effect? Method Thirty-nine healthy participants participated in two sessions: FAM and sham meditation (SHAM). The participants conducted each meditation for 10 min. The state effect on response inhibition processes was observed as Stroop task performance immediately before and after each meditation, and 20, 40, and 60 min after each meditation. In addition, the subjective effort toward meditation was evaluated using a questionnaire immediately after each meditation. Results An analysis of variance revealed a significant interaction between session and time. In the post-hoc analysis, FAM showed significantly better Stroop task performance than the SHAM 60 min after meditation. Furthermore, using correlational analysis, we found that at 60 min, the higher the subjective effort, the better Stroop task performance. Conclusions In contrast to previous findings, the state effect was not found immediately after FAM but instead 60 min after. The results can be partially explained by cognitive fatigue; that is, the FAM may have the state effect of preventing cognitive fatigue. This state effect is greater when the subjective effort is greater.

  30. Dynamic functional connectivity associated with prospective memory success in children

    Teruo Hashimoto, Susumu Yokota, Satoshi Umeda, Ryuta Kawashima

    Neuroimage: Reports　2　(4)　2022/12

    DOI： 10.1016/j.ynirp.2022.100144 　

    eISSN： 2666-9560

  31. Mercury levels in hair are associated with reduced neurobehavioral performance and altered brain structures in young adults

    Hikaru Takeuchi, Yuka Shiota, Ken Yaoi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

    Communications Biology　5　(1)　2022/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s42003-022-03464-z 　

    eISSN： 2399-3642

    More details Close

    Abstract The detrimental effects of high-level mercury exposure on the central nervous system as well as effects of low-level exposure during early development have been established. However, no previous studies have investigated the effects of mercury level on brain morphometry using advance imaging techniques in young adults. Here, utilizing hair analysis which has been advocated as a method for biological monitoring, data of regional gray matter volume (rGMV), regional white matter volume (rWMV), fractional anisotropy (FA) and mean diffusivity (MD), cognitive functions, and depression among 920 healthy young adults in Japan, we showed that greater hair mercury levels were weakly but significantly associated with diminished cognitive performance, particularly on tasks requiring rapid processing (speed measures), lower depressive tendency, lower rGMV in areas of the thalamus and hippocampus, lower rWMV in widespread areas, greater FA in bilaterally distributed white matter areas overlapping with areas of significant rWMV reductions and lower MD of the widely distributed gray and white matter areas particularly in the bilateral frontal lobe and the right basal ganglia. These results suggest that even normal mercury exposure levels in Japan are weakly associated with differences of brain structures and lower neurobehavioral performance and altered mood among young adults.

  32. Academic achievements and brain volume development in children and adolescents

    Teruo Hashimoto, Yutaka Matsuzaki, Susumu Yokota, Ryuta Kawashima

    Cerebral Cortex Communications　2022/11/16

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/texcom/tgac048 　

    eISSN： 2632-7376

    More details Close

    Abstract Children are expected to acquire both basic and numeric skills. Achievement of higher levels of reading, writing, arithmetic, and vocabulary are favorable and desirable. The relationship between each literacy skill and neural development has been investigated; however, association between brain development and the four literacy skills has not been examined. This longitudinal, structural, neuroimaging study explored the contribution of higher academic achievement in reading, writing, arithmetic, and vocabulary to neural development. The brain volumes of children and adolescents aged 9–16 years were measured in the first test. Approximately 2.6 years later, the brain volumes and four academic achievement scores of 77 participants were measured in the second test. Changes in the gray matter volume in the left fusiform gyrus were associated with vocabulary scores, while those in the left striatum were associated with arithmetic scores. The reading and writing scores showed no statistically significant relationship with changes in brain volume. The current vocabulary score correlated with current gray matter volume, while brain volumes in the first test showed no association with any achievement scores. These results suggest that academic achievement may modulate brain plasticity in various ways.

  33. The effect of action contingency on social perception is independent of person-like appearance and is related to deactivation of the frontal component of the self-agency network. International-journal

    Yumi Hamamoto, Yukiko Takahara, Kelssy Hitomi Dos Santos Kawata, Tatsuo Kikuchi, Shinsuke Suzuki, Ryuta Kawashima, Motoaki Sugiura

    Scientific reports　12　(1)　17326-17326　2022/10/15

    DOI： 10.1038/s41598-022-22278-x 　

    More details Close

    The detection of object movement that is contingent on one's own actions (i.e., movements with action contingency) influences social perception of the object; such interactive objects tend to create a good impression. However, it remains unclear whether neural representation of action contingency is associated with subsequent socio-cognitive evaluation of "contacting agents", or whether the appearance of agents (e.g., face- or non-face-like avatars) is essential for this effect. In this study, we conducted a functional magnetic resonance imaging (fMRI) task with two phases: contact (contact with face- or non-face-like avatars moving contingently or non-contingently) and recognition (rating a static image of each avatar). Deactivation of the frontoparietal self-agency network and activation of the reward network were the main effects of action contingency during the contact phase, consistent with previous findings. During the recognition phase, static avatars that had previously moved in a contingent manner deactivated the frontal component of the frontoparietal network (bilateral insula and inferior-middle frontal gyri), regardless of person-like appearance. Our results imply that frontal deactivation may underlie the effect of action contingency on subsequent social perception, independent of person-like appearance.

  34. Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip

    Chihiro Kitayama, Eriya Shimada, Hiroki Hihara, Akitake Kanno, Nobukazu Nakasato, Yoshimichi Imai, Akimitsu Sato, Ryuta Kawashima, Kaoru Igarashi, Hiroyasu Kanetaka

    PLOS ONE　17　(9)　e0274405-e0274405　2022/09/22

    Publisher: Public Library of Science (PLoS)

    DOI： 10.1371/journal.pone.0274405 　

    eISSN： 1932-6203

    More details Close

    Background Cleft lip is the most common congenital anomaly worldwide. Nevertheless, lip somatosensory characteristics of patients with cleft lip after cheiloplasty have not yet been determined. The present study used magnetoencephalography to objectively evaluate the lip sensation in patients with unilateral cleft lip to establish a new objective evaluation method. Methods Participants were 15 patients with unilateral cleft lip after cheiloplasty (UCL group), and 30 healthy young subjects (control group). Five points of the upper and lower lips were stimulated electrically to measure somatosensory evoked magnetic fields (SEFs). The sources of the magnetic fields were modeled as single equivalent current dipoles (ECDs). ECDs located on the central sulcus by superimposition on magnetic resonance images were analyzed. Latency and intensity at 50–75 ms (cP60m) observed in the UCL group were compared with those in the control group. Thresholds of tactile stimuli in both groups were obtained using Semmes–Weinstein monofilaments for subjective sensory evaluation. Results No significant difference was found in the intensity of the cP60m or subjective evaluation between the groups. However, the latency of the cP60m was significantly longer in the upper lip of the UCL group than in the control group. Conclusions SEFs showed a difference in lip sensation between the UCL group and the control group, suggesting that longer latency might be caused by the effects of surgical scarring on the neurotransmission pathway. These results suggest SEFs as useful for the objective evaluation of lip sensations. This study might improve future surgical procedures and lip functions of patients with cleft lip.

  35. Brain Anatomy Alterations and Mental Health Challenges Correlate to Email Addiction Tendency

    Saeid Sadeghi, Hikaru Takeuchi, Bita Shalani, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

    Brain Sciences　12　(10)　1278-1278　2022/09/22

    Publisher: MDPI AG

    DOI： 10.3390/brainsci12101278 　

    eISSN： 2076-3425

    More details Close

    Despite the widespread use of email, our knowledge regarding the consequences of email addiction is lacking. The purpose of this study was to develop an email addiction tendency scale to evaluate its correlation to behavior and brain structure. Following this, the validity and reliability of the developed scale was investigated. We used voxel-based morphometry, correlation, and univariate regression analysis to assess the relationships between email addiction tendency scores and regional gray and white matter volumes, depression, and nonverbal reasoning abilities in a large sample of healthy young adults (n = 1152; mean age, 20.69 ± 1.84 years). The content validity ratio, content validity index, principal component analysis, and confirmatory factorial analysis all showed that the email addiction tendency scale (EATS) has high validity. Additionally, the Cronbach’s alpha internal consistency and split-half reliability coefficient showed that the EATS has high reliability. We found that email addiction tendency scores were significantly negatively correlated with nonverbal reasoning. We also observed that the email addiction tendency scores were significantly and positively correlated with depression symptom severity and gray matter volume of the left rostrolateral prefrontal cortex (RLPC) in subjects. These results indicate that email addiction tendency is associated with lower mental health outcomes and increased GMV in the left RLPC.

  36. Sex interaction of white matter microstructure and verbal IQ in corpus callosum in typically developing children and adolescents. International-journal

    Susumu Yokota, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

    Brain & development　44　(8)　531-539　2022/09

    DOI： 10.1016/j.braindev.2022.04.003 　

    More details Close

    BACKGROUND: Childhood is an extremely important time for neural development that has a critical role in human intelligence. Efficient information processing is crucial for higher intelligence, so the intra- or inter-hemispheric interaction is vital. However, the relationship between neuroanatomical connections and intelligence in typically developing children, as well as sex differences in this relationship, remains unknown. METHODS: Participants were 253 typically developing children (121 boys and 132 girls) aged 5-18. We acquired diffusion tensor imaging data and intelligence using an age-appropriate version of the IQ test; Wechsler Intelligence Scale for Children (WISC) or Wechsler Adult Intelligence Scale (WAIS). We conducted whole-brain multiple regression analysis to investigate the association between fractional anisotropy (FA), which reflects white matter microstructural properties, and each composite score of IQ test (full-scale IQ, performance IQ, and verbal IQ). RESULTS: FA was positively correlated with full-scale IQ in bilateral inferior occipitofrontal fasciculus, genu, and splenium of corpus callosum (CC). FA in the right superior longitudinal fasciculus, bilateral inferior longitudinal fasciculus, and splenium of CC were also positively correlated with performance IQ. Furthermore, we found significant sex interaction between FA in the CC and verbal IQ. FA was positively correlated in boys, and negatively correlated in girls. CONCLUSION: Results suggest that efficient anatomical connectivity between parietal and frontal regions is crucial for children's intelligence. Moreover, inter-hemispheric connections play a critical role in verbal abilities in boys.

  37. 【視覚誘発電位・磁界、聴覚誘発電位・磁界】聴性誘発脳磁界(N1m) 音楽による影響と選択的注意

    白倉 真之, 川瀬 哲明, 菅野 彰剛, 太田 淳, 中里 信和, 川島 隆太, 香取 幸夫

    臨床神経生理学　50　(4)　138-142　2022/08

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  38. 【視覚誘発電位・磁界、聴覚誘発電位・磁界】聴性誘発脳磁界(N1m) 音楽による影響と選択的注意

    白倉 真之, 川瀬 哲明, 菅野 彰剛, 太田 淳, 中里 信和, 川島 隆太, 香取 幸夫

    臨床神経生理学　50　(4)　138-142　2022/08

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  39. Somatosensory Evoked Magnetic Fields Induced by Electrical Palate Stimulation in Patients with Unilateral Cleft Lip and Palate after Palatoplasty

    Eriya Shimada, Hiroki Hihara, Chihiro Kitayama, Akitake Kanno, Ryuta Kawashima, Akimitsu Sato, Yoshimichi Imai, Nobukazu Nakasato, Kaoru Igarashi, Hiroyasu Kanetaka

    Neuroscience Research　184　30-37　2022/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.neures.2022.08.002 　

    ISSN： 0168-0102

  40. Effects of Body Mass Index on Brain Structures in the Elderly: Longitudinal Analyses

    Hikaru Takeuchi, Ryuta Kawashima

    Frontiers in Endocrinology　13　2022/06/03

    Publisher: Frontiers Media SA

    DOI： 10.3389/fendo.2022.824661 　

    eISSN： 1664-2392

    More details Close

    The relationship between obesity and neurocognitive consequences is complex. Here we investigated associations between body mass index (BMI) and subsequent changes in brain structures, cognitive changes, and the onset of dementia after adjustment of a wide range of potential confounding variables using a large prospective cohort data of UK Biobank. After correcting for confounding factors, higher BMI was associated with greater retention in visuospatial memory performance (decline in error numbers) [beta = -0.019 (CI:-0.027~-0.016), N = 39191], increase in depression tendency scores [beta = 0.036(0.027~0.045)] as well as decreased risk of incident dementia [increasing BMI by 1 is associated with HR of 0.981 (CI:0.969~0.992), N = 398782], but not changes in fluid intelligence or reaction time. Whole brain multiple regression analyses (volumetric analyses: N = 1253, other analyses: N = 1241) revealed positive associations between BMI and subsequent changes in regional gray matter volume (rGMV) in multiple areas, regional white matter volume changes in widespread white matter (WM) tracts, fractional anisotropy changes in several tracts, and intracellular volume fraction (ICVF) and orientation dispersion (OD) in widespread areas, and isotropic volume fraction (ISOVF) in a few areas, and negative associations between BMI and subsequent changes in rGMV in the bilateral medial temporal lobe areas, mean, axial and radial diffusivity, and ISOVF in widespread areas. These results are mostly consistent with the view that less BMI precedes greater neurocognitive aging or atrophy, with a few exceptions including OD findings and the rGMV finding of the medial temporal lobes as most of significant longitudinal associations of higher BMI were opposite to those seen in higher age and dementia. Future epidemiological studies should consider separating effects of higher BMI itself from potential confounders.

  41. Morphological comparison of masseter muscle fibres in the mandibular rest and open positions using diffusion tensor imaging. International-journal

    Takehiko Sugano, Toru Ogawa, Nobuhiro Yoda, Teruo Hashimoto, Kenta Shobara, Kuniyasu Niizuma, Ryuta Kawashima, Keiichi Sasaki

    Journal of oral rehabilitation　49　(6)　608-615　2022/06

    DOI： 10.1111/joor.13319 　

    More details Close

    BACKGROUND: The masseter muscle has a complicated multipennate internal structure and exhibits functional differentiation when performing various stomatognathic functions. It is important to understand the internal structural changes of the muscle during functioning to elucidate characteristic muscle disorders such as local myalgia. Diffusion tensor imaging (DTI) may be useful for investigating the internal structural features of muscle. OBJECTIVES: To evaluate the features of masseter muscle fibres in human participants using DTI fibre tractography, and to elucidate the structural differences in the masseter muscle between the mandibular rest and open positions. METHODS: Five healthy men (age 31 ± 7 years) underwent DTI and T1-weighted MRI of the right masseter muscle in the mandibular rest and open positions. MR images were used as a reference for muscle layer segmentation (superficial, intermediate, and deep). DTI fibre tractography of the masseter muscle was performed and the orientation of the DTI fibres was analysed in each layer using coordinates based on the Frankfurt horizontal plane. RESULTS: The DTI fibre orientation of the deep layer significantly changed between the mandibular rest and open positions in the frontal plane (p < 0.05, Wilcoxon rank sum test). However, no significant change was found in the superficial and intermediate layers. CONCLUSION: DTI fibre tractography confirmed regional differences in the orientation change of the masseter muscle fibres between different mandibular positions. The results may support the existence of functional partitioning inside the masseter muscle and suggest that DTI may be useful for the evaluation of muscle fibres in multipennate muscles.

  42. Common and distinct neural bases of multiple positive emotion regulation strategies: A functional magnetic resonance imaging study. International-journal

    Masayuki Tsujimoto, Toshiki Saito, Yutaka Matsuzaki, Risako Kojima, Ryuta Kawashima

    NeuroImage　257　119334-119334　2022/05/26

    DOI： 10.1016/j.neuroimage.2022.119334 　

    More details Close

    Appropriate emotion regulation is crucially involved in mental and physical health. The neural basis of negative but not positive emotion regulation has been well investigated. Several strategies should be compared to elucidate the neural correlates of positive emotion regulation. However, there are no studies on multiple positive emotion regulation strategies. We aimed to investigate the neural correlates of positive emotion regulation with multiple emotion regulation strategies and identify common and differential brain areas involved in positive emotion upregulation. We acquired functional magnetic resonance imaging data from healthy college student volunteers while they upregulated positive emotions through instructed strategies or by viewing positive pictures. The instructed strategies included Attentional Deployment, Cognitive Change, and Response Modulation. These strategies increased subjective positive emotions and activation of the prefrontal cortex (PFC) and anterior cingulate cortex (ACC). Region of interest analysis revealed greater activation of the ventral striatum during positive emotion regulation. There are different networks involved in Cognitive Change and Response Modulation. Our findings indicate that multiple strategies for positive emotion upregulation involve common (e.g., PFC, ACC, and ventral striatum) and unique networks.

  43. Neuroendocrine Response and State Anxiety Due to Psychosocial Stress Decrease after a Training with Subject's Own (but Not Another) Virtual Body: An RCT Study. International-journal

    Dalila Burin, Gabriele Cavanna, Daniela Rabellino, Yuka Kotozaki, Ryuta Kawashima

    International journal of environmental research and public health　19　(10)　2022/05/23

    DOI： 10.3390/ijerph19106340 　

    More details Close

    Previous research involving healthy participants has reported that seeing a moving virtual body from the first person perspective induces the illusion of ownership and agency over that virtual body. When a person is sitting and the virtual body runs, it is possible to measure physiological, behavioral and cognitive reactions that are comparable to those that occur during actual movement. Capitalizing on this evidence, we hypothesized that virtual training could also induce neuroendocrine effects that prompt a decreased psychosocial stress response, as occurs after physical training. While sitting, 26 healthy young adults watched a virtual avatar running for 30 min from the first person perspective (experimental group), while another 26 participants watched the virtual body from the third person perspective (control group). We found a decreased salivary alpha-amylase concentration (a biomarker for the stress response) after the virtual training among the experimental group only, as well as a decreased subjective feeling of state anxiety (but no difference in heart rate). We argue that the virtual illusion of a moving body from the first person perspective can initiate a cascade of events, from the perception of the visual illusion to physiological activation that triggers other biological effects, such as the neuroendocrine stress response.

  44. A Prospective Study on the Relationship Between Driving and Non-occupational Computer Use With Risk of Dementia

    Hikaru Takeuchi, Ryuta Kawashima

    Frontiers in Aging Neuroscience　14　2022/05/16

    Publisher: Frontiers Media SA

    DOI： 10.3389/fnagi.2022.854177 　

    eISSN： 1663-4365

    More details Close

    Sedentary behaviors have been associated with the risk of dementia in older adults. Whether driving and computer use are associated with the risk of dementia in older adults is an important research question. The participants of a longitudinal cohort study that included European middle- and old-aged adults at the baseline (2006–2010) who had not been diagnosed with dementia before 5 years after the baseline and had not died within 5 years after the baseline were followed up (until 2018) and analyzed. The associations between driving and non-occupational computer use time measured by the questionnaire at the baseline and incident dementia 5 years after the baseline were analyzed after correcting for confounding variables. Each analysis included approximately 370,000 participants and 1,000 cases. According to Cox proportional hazard models that divide subjects into four groups of habit duration levels [(a) 0 h; (b) less than 1 h, 1 h; (c), 2 h, 3 h; (d) 4 h or more, per/day)], the group with 0 h &amp;lt; driving time ≤1 h at the baseline exhibited a significantly lower risk of incident dementia than the other groups. In addition, in the analysis of non-occupational computer use duration, the 0 h group exhibited a significantly higher risk than the other groups. Our results indicate that different sedentary behaviors have different associations with dementia risk over time and have no simple dose–response relationship with dementia risk. The sedentary behavior risk assessments must consider these factors.

  45. RELN rs7341475 Associates with Brain Structure in Japanese Healthy Females. International-journal

    Ryo Yamaguchi, Izumi Matsudaira, Hikaru Takeuchi, Tadashi Imanishi, Ryosuke Kimura, Hiroaki Tomita, Ryuta Kawashima, Yasuyuki Taki

    Neuroscience　494　38-50　2022/05/13

    DOI： 10.1016/j.neuroscience.2022.05.007 　

    More details Close

    Although temperament has been regarded as an innate aspect of human personality, its association with proteins involved in embryonic development is unclear. Reelin, encoded by RELN, plays an important role in brain development. Herein, we investigated the association between the RELN rs7341475 (G/A) single nucleotide polymorphism, detected as a female-specific risk factor for schizophrenia, brain structure, and temperament to elucidate the role of RELN in the development of human personality. In this study, 1580 healthy young Japanese adults were genotyped for RELN rs7341475 and completed the Temperament and Character Inventory. Whole-brain analysis of covariance was conducted to investigate differences between genotypes in regional gray matter volume (rGMV) and cortical morphology. Additionally, multiple regression analysis was performed to examine the association of four temperaments with rGMV. Those statistical analyses were performed separately for males and females. Individuals with G/G homozygosity showed significantly greater rGMV in several areas of the brain, particularly the bilateral cingulate and temporal gyrus, as well as a larger value of fractal dimension in the left lateral occipital cortex. Furthermore, of the four temperaments, the novelty seeking was significantly and positively associated with rGMV in the right superior temporal gyrus, partially overlapping with areas where differences between the rs7341475 genotypes were detected. The above findings were detected only in females, but not in males. This is the first study to demonstrate the contribution of RELN rs7341475 to differences in brain structure in Japanese females, which may indicate vulnerability to schizophrenia and variations in human personality.

  46. Loneliness inside of the brain: evidence from a large dataset of resting-state fMRI in young adult. International-journal

    Denilson Brilliant T, Hikaru Takeuchi, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Sugiko Hanawa, Atsushi Sekiguchi, Shigeyuki Ikeda, Kohei Sakaki, Kelssy Hitomi Dos Santos Kawata, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

    Scientific reports　12　(1)　7856-7856　2022/05/12

    DOI： 10.1038/s41598-022-11724-5 　

    More details Close

    Although loneliness itself is a natural emotion, prolonged loneliness is detrimental to human health. Despite its detrimental effect, few loneliness-related neuroimaging studies have been published and some have limitations on the sample size number. This study aims to find the difference in resting-state functional connectivity associated with loneliness within a big sample size via the seed-based approach. Functional connectivity analysis was performed on a large cohort of young adults (N = 1336) using the seed-based functional connectivity approach to address the concern from previous studies. The analysis yielded statistically significant positive correlations between loneliness and functional connectivities between the inferior frontal gyrus and supplementary motor area, precentral gyrus, and superior parietal lobule. Additionally, the analysis replicated a finding from a previous study, which is increased functional connectivities between the inferior frontal gyrus and supplementary motor area. In conclusion, greater loneliness is reflected by stronger functional connectivity of the visual attention brain area.

  47. Somatosensory evoked magnetic fields caused by mechanical stimulation of the periodontal ligaments. International-journal

    Eriya Shimada, Hiroyasu Kanetaka, Hiroki Hihara, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato, Kaoru Igarashi

    Heliyon　8　(5)　e09464　2022/05

    DOI： 10.1016/j.heliyon.2022.e09464 　

    More details Close

    The periodontal ligaments are very important sensory organ for our daily life such as perception of food size or hardness, determination of jaw position, and adjustment of masticatory strength. The sensory properties of the periodontal ligament, especially those of the maxillary and mandibular molars, have not yet been fully investigated. Somatosensory evoked magnetic fields (SEFs) can be measured and evaluated for latency and intensity to determine the sensory transmission characteristics of each body parts. However, previous reports on SEFs in the oral region have only reported differences in upper and lower gingival and lip sensations. In this study, the aim was to clarify these sensory characteristics by measuring SEFs during mechanical stimulation of the periodontal ligament in the maxillary and mandibular first molars. Somatosensory evoked magnetic fields were measured in the contralateral hemispheres of 33 healthy volunteers. Mechanical stimulation of the maxillary and mandibular right first molars, and the left wrist was performed with a specific handmade tool. The first peak latency for the mandibular first molars was 41.7 ± 5.70 ms (mean ± SD), significantly shorter than that for the maxillary first molars at 47.7 ± 7.36 ms. The peak intensity for the mandibular first molars was 13.9 ± 6.06 nAm, significantly larger than that for the maxillary first molars at 7.63 ± 3.55 nAm. The locations in the contralateral hemispheres showed no significant difference between the maxillary first molars and mandibular first molars. These locations were more anteroinferior and exterior than that of the wrist, as suggested by the brain homunculus. Neural signals from the mandibular periodontal ligaments pass faster and more intensely to the central nervous system than those from the maxillary periodontal ligaments, and may preferentially participate in adjustment of the occlusal force and the occlusal position.

  48. Neural correlates of Japanese honorific agreement processing mediated by socio-pragmatic factors: An fMRI study

    Haining Cui, Hyeonjeong Jeong, Kiyo Okamoto, Daiko Takahashi, Ryuta Kawashima, Motoaki Sugiura

    Journal of Neurolinguistics　62　101041-101041　2022/05

    Publisher: Elsevier BV

    DOI： 10.1016/j.jneuroling.2021.101041 　

    ISSN： 0911-6044

  49. A psychiatric disorder risk polymorphism of <scp>ITIH3</scp> is associated with multiple neuroimaging phenotypes in young healthy adults

    Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono(Tanaka), Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Tadashi Imanishi, Ryuta Kawashima

    Psychiatry and Clinical Neurosciences　2022/04/05

    Publisher: Wiley

    DOI： 10.1111/pcn.13347 　

    ISSN： 1323-1316

    eISSN： 1440-1819

  50. Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study

    Tatsushi Mutoh, Keiko Kunitoki, Yasuko Tatewaki, Shuzo Yamamoto, Benjamin Thyreau, Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki

    GeroScience　2022/04/05

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11357-022-00553-z 　

    ISSN： 2509-2715

    eISSN： 2509-2723

  51. Shame proneness is associated with individual differences in temporal pole white matter structure. International-journal

    Carlos Makoto Miyauchi, Hikaru Takeuchi, Yasuyuki Taki, Seishu Nakagawa, Sugiko Hanawa, Atsushi Sekiguchi, Rui Nouchi, Yuko Sassa, Ryuta Kawashima

    Social neuroscience　17　(2)　117-126　2022/04

    DOI： 10.1080/17470919.2022.2039287 　

    More details Close

    Shame and guilt are distinct negative moral emotions, although they are usually regarded as overlapping affective experiences. Of these two emotions, shame is more closely related to concerns about other people's judgment, whereas guilt is more related to concerns about one's own judgment. Although some studies have tried to identify the psychological process underlying shame as opposed to guilt, there is no clear evidence of brain regions that are specifically relevant to the experience of shame rather than guilt and, more generally, self-blame. We therefore investigated associations between individual differences in shame- and guilt-proneness and the gray and white matter structures of the brain using magnetic resonance imaging and voxel-based morphometry while controlling for associations with guilt- or shame-proneness. To accomplish this goal, we enrolled 590 healthy, right-handed individuals (338 men and 252 women; age, 20.6 ± 1.8 years). We administered a questionnaire to assess shame proneness and guilt proneness. Based on our hypothesis, we found that high shame proneness was associated with decreased regional white matter density only in the right inferior temporal pole, whereas no significant region was associated with guilt. The function of this area may be important for the underlying processes differentiating shame from guilt.

  52. An fMRI validation study of the word-monitoring task as a measure of implicit knowledge: Exploring the role of explicit and implicit aptitudes in behavioral and neural processing

    Yuichi Suzuki, Hyeonjeong Jeong, Haining Cui, Kiyo Okamoto, Ryuta Kawashima, Motoaki Sugiura

    Studies in Second Language Acquisition　1-28　2022/03/28

    Publisher: Cambridge University Press (CUP)

    DOI： 10.1017/s0272263122000043 　

    ISSN： 0272-2631

    eISSN： 1470-1545

    More details Close

    Abstract In this study, neural representation of adult second language (L2) speakers’ implicit grammatical knowledge was investigated. Advanced L2 speakers of Japanese living in Japan, as well as L1 Japanese speakers, performed a word-monitoring task (proposed as an implicit knowledge test) in the MRI scanner. Behavioral measures were obtained from aptitude tests for explicit (language analytic ability) and implicit (statistical learning ability) learning. Findings indicate that, although both L1 and L2 speakers recruited neural circuits associated with procedural memory during the word-monitoring task, different brain regions were activated: premotor cortex (L1 speakers) and left caudate (L2 speakers). The premotor cortex activation was weaker in L2 than L1 speakers but was positively correlated with the left caudate activation, suggesting that their grammatical knowledge, while less automatized, was still developing. Behavioral sensitivity to errors was predicted only by explicit language aptitude, which may play a key role in the automatization of grammatical knowledge.

  53. Auditory Cognitive Training Improves Brain Plasticity in Healthy Older Adults: Evidence From a Randomized Controlled Trial. International-journal Peer-reviewed

    Natasha Y S Kawata, Rui Nouchi, Kentaro Oba, Yutaka Matsuzaki, Ryuta Kawashima

    Frontiers in aging neuroscience　14　826672-826672　2022/03

    DOI： 10.3389/fnagi.2022.826672 　

    More details Close

    The number of older adults is increasing globally. Aging is associated with cognitive and sensory decline. Additionally, declined auditory performance and cognitive function affect the quality of life of older adults. Therefore, it is important to develop an intervention method to improve both auditory and cognitive performances. The current study aimed to investigate the beneficial effects of auditory and cognitive training on auditory ability and cognitive functions in healthy older adults. Fifty healthy older adults were randomly divided into four training groups-an auditory-cognitive training group (AC training; n = 13), an auditory training group (A training; n = 13), a cognitive training group (C training; n = 14), and an active control group (n = 12). During the training period, we reduced the sound intensity level in AC and A training groups and increase training task difficulty in AC, A, and C training groups based on participants' performance. Cognitive function measures [digit-cancelation test (D-CAT); logical memory (LM); digit span (DS)], auditory measures [pure-tone audiometry (PTA)], and magnetic resonance imaging (MRI) scans were performed before and after the training periods. We found three key findings. First, the AC training group showed difference between other training groups (A, C, and active control training groups) in regional gray matter volume (rGMV) in the right dorsolateral prefrontal cortex, the left inferior temporal gyrus (L. ITG), the left superior frontal gyrus, the left orbitofrontal cortex, the right cerebellum (lobule 7 Crus 1). Second, the auditory training factor groups (ATFGs, the AC and A training groups) improved auditory measures and increased the rGMV and functional connectivity (FC) in the left temporal pole compared to the non-ATFGs (the C training group and active control group). Third, the cognitive training factor groups (CTFGs; the AC and C training groups) showed statistically significant improvement in cognitive performances in LM and D-CAT compared to the non-CTFGs (the A training group and active control group). Therefore, the auditory training factor and cognitive training factor would be useful in enhancing the quality of life of older adults. The current AC training study, the plasticity of the brain structure was observed after 4 weeks of training.

  54. Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in mice. International-journal

    Takeshi Hiramoto, Akira Sumiyoshi, Takahira Yamauchi, Kenji Tanigaki, Qian Shi, Gina Kang, Rie Ryoke, Hiroi Nonaka, Shingo Enomoto, Takeshi Izumi, Manzoor A Bhat, Ryuta Kawashima, Noboru Hiroi

    Molecular psychiatry　27　(2)　929-938　2022/02

    DOI： 10.1038/s41380-021-01318-4 　

    More details Close

    Copy number variants (CNVs) have provided a reliable entry point to identify the structural correlates of atypical cognitive development. Hemizygous deletion of human chromosome 22q11.2 is associated with impaired cognitive function; however, the mechanisms by which the CNVs contribute to cognitive deficits via diverse structural alterations in the brain remain unclear. This study aimed to determine the cellular basis of the link between alterations in brain structure and cognitive functions in mice with a heterozygous deletion of Tbx1, one of the 22q11.2-encoded genes. Ex vivo whole-brain diffusion-tensor imaging (DTI)-magnetic resonance imaging (MRI) in Tbx1 heterozygous mice indicated that the fimbria was the only region with significant myelin alteration. Electron microscopic and histological analyses showed that Tbx1 heterozygous mice exhibited an apparent absence of large myelinated axons and thicker myelin in medium axons in the fimbria, resulting in an overall decrease in myelin. The fimbria of Tbx1 heterozygous mice showed reduced mRNA levels of Ng2, a gene required to produce oligodendrocyte precursor cells. Moreover, postnatal progenitor cells derived from the subventricular zone, a source of oligodendrocytes in the fimbria, produced fewer oligodendrocytes in vitro. Behavioral analyses of these mice showed selectively slower acquisition of spatial memory and cognitive flexibility with no effects on their accuracy or sensory or motor capacities. Our findings provide a genetic and cellular basis for the compromised cognitive speed in patients with 22q11.2 hemizygous deletion.

  55. Application of Diffusion Tensor Imaging Fiber Tractography for Human Masseter Muscle.

    Takehiko Sugano, Nobuhiro Yoda, Toru Ogawa, Teruo Hashimoto, Kenta Shobara, Kuniyasu Niizuma, Ryuta Kawashima, Keiichi Sasaki

    The Tohoku journal of experimental medicine　256　(2)　151-160　2022/02

    DOI： 10.1620/tjem.256.151 　

    More details Close

    Diffusion tensor imaging (DTI) has been used to indicate the direction of nerve and muscle fibers by using the characteristics that water molecules preferentially diffuse along the fibrous structure. However, DTI fiber tractography for multipennate muscles, such as the masseter muscle, is challenging due to a lack of data regarding the imaging parameters. This study aimed to determine the optimal DTI parameters for masseter muscle fiber tractography. A 27-year-old healthy man voluntarily underwent DTI and T1-weighted magnetic resonance imaging of the right masseter muscle. Four imaging parameter settings were created by combining the following parameters that particularly affect the signal-to-noise ratio: b-value, number of excitations (NEX), and number of motion probing gradient (MPG) directions. DTI fiber tractography was performed using specific software for each parameter setting. The length and orientation of the muscle fibers in each layer were calculated. As a result, the masseter muscle fibers of each layer were identified on DTI. Although the detected fiber length was affected significantly by the imaging parameters, the fiber orientation was insignificantly affected. The appropriate combination of the b-value, NEX, and the number of MPG directions for masseter muscle fiber tractography could be determined based on previously reported anatomical data of the masseter muscle fibers. DTI may enable the non-invasive evaluation of masseter muscle fiber length and orientation. Elucidation of the details of masseter muscle fiber orientation is useful in evaluating stomatognathic biomechanics and muscle disorders.

  56. Neural Correlates Predicting Lane-Keeping and Hazard Detection: An fMRI Study Featuring a Pedestrian-Rich Simulator Environment. International-journal Peer-reviewed

    Kentaro Oba, Koji Hamada, Azumi Tanabe-Ishibashi, Fumihiko Murase, Masaaki Hirose, Ryuta Kawashima, Motoaki Sugiura

    Frontiers in human neuroscience　16　754379-754379　2022/02

    DOI： 10.3389/fnhum.2022.754379 　

    More details Close

    Distracted attention is considered responsible for most car accidents, and many functional magnetic resonance imaging (fMRI) researchers have addressed its neural correlates using a car-driving simulator. Previous studies, however, have not directly addressed safe driving performance and did not place pedestrians in the simulator environment. In this fMRI study, we simulated a pedestrian-rich environment to explore the neural correlates of three types of safe driving performance: accurate lane-keeping during driving (driving accuracy), the braking response to a preceding car, and the braking response to a crossing pedestrian. Activation of the bilateral frontoparietal control network predicted high driving accuracy. On the other hand, activation of the left posterior and right anterior superior temporal sulci preceding a sudden pedestrian crossing predicted a slow braking response. The results suggest the involvement of different cognitive processes in different components of driving safety: the facilitatory effect of maintained attention on driving accuracy and the distracting effect of social-cognitive processes on the braking response to pedestrians.

  57. Effects of sulforaphane intake on processing speed and negative moods in healthy older adults: Evidence from a randomized controlled trial. International-journal

    Rui Nouchi, Qingqiang Hu, Yusuke Ushida, Hiroyuki Suganuma, Ryuta Kawashima

    Frontiers in aging neuroscience　14　929628-929628　2022

    DOI： 10.3389/fnagi.2022.929628 　

    More details Close

    BACKGROUND: Recent studies have reported that sulforaphane (SFN) intake with cognitive training had positive effects on cognitive functions. However, it is still unknown whether SFN intake alone has beneficial effects on cognition as well as mood. We investigated whether a SFN intake intervention improved cognitive performance and mood states in healthy older adults. METHODS: In a 12-week, double-blinded, randomized controlled trial (RCT), we randomly assigned 144 older adults to a SFN group or a placebo group. We asked the participants to take a supplement (SFN or placebo) for 12 weeks. We measured several cognitive functions, mood states, and biomarkers before and after the intervention period. RESULTS: The SFN group showed improvement in processing speed and a decrease in negative mood compared to the placebo group. In addition, the SFN group exhibited a higher SFN-N-acetyl-L-cysteine (NAC) level compared to the placebo group. However, there were no significant results in other biomarkers of oxidant stress, inflammation, or neural plasticity. DISCUSSION: These results indicate that nutrition interventions using SFN can have positive effects on cognitive functioning and mood in healthy older adults.

  58. Cognitive Training with Neurofeedback Using NIRS Improved Cognitive Functions in Young Adults: Evidence from a Randomized Controlled Trial. International-journal

    Rui Nouchi, Haruka Nouchi, Jerome Dinet, Ryuta Kawashima

    Brain sciences　12　(1)　2021/12/21

    DOI： 10.3390/brainsci12010005 　

    More details Close

    (1) Background: A previous study has shown that cognitive training with neurofeedback (CT-NF) using down-regulation improves cognitive functions in young adults. Neurofeedback has two strategies for manipulating brain activity (down-regulation and upregulation). However, the benefit of CT-NF with the upregulation of cognitive functions is still unknown. In this study, we investigated whether the upregulation of CT-NF improves a wide range of cognitive functions compared to cognitive training alone. (2) Methods: In this double-blinded randomized control trial (RCT), 60 young adults were randomly assigned to one of three groups: CT-NF group, CT alone group, and an active control (ACT) group who played a puzzle game. Participants in the three groups used the same device (tablet PC and 2ch NIRS (near-infrared spectroscopy)) and performed the training game for 20 min every day for four weeks. We measured brain activity during training in all groups, but only CT-NFs received NF. We also measured a wide range of cognitive functions before and after the intervention period. (3) Results: The CT-NF groups showed superior beneficial effects on episodic memory, working memory, and attention compared to the CT alone and ACT groups. In addition, the CT-NF group showed an increase in brain activity during CT, which was associated with improvements in cognitive function. (4) Discussion: This study first demonstrated that the CT-NF using the upregulation strategy has beneficial effects on cognitive functions compared to the CT alone. Our results suggest that greater brain activities during CT would enhance a benefit from CT.

  59. Diet and Dementia: A Prospective Study

    Hikaru Takeuchi, Ryuta Kawashima

    Nutrients　13　(12)　4500-4500　2021/12/16

    Publisher: MDPI AG

    DOI： 10.3390/nu13124500 　

    eISSN： 2072-6643

    More details Close

    Whether dietary and nutrition and dietary patterns are associated with the development of dementia is an interesting research question. Participants of a longitudinal cohort study that included European adults who were middle to old aged at baseline and who had not been diagnosed with dementia at baseline (2006–2010) and had not been diagnosed with dementia or died within 5 years after baseline were followed up (until 2018) and analyzed. Associations between intake frequency of each food class measured by the food-frequency questionnaire at baseline and incident dementia 5 years after baseline were analyzed after correcting for confounding variables. A total of approximately 340,000 participants and 900 cases were included in the analysis for each food class. Cox proportional hazard models with self-reported intake level of each food category divided into four mostly equally divided categorical variables revealed a high intake of bread, moderate total meat and total fish intake and low vegetable and fruit intake were thus associated with a small but significant decrease in the onset risk of dementia, while poultry and cereal were not. These findings are mostly inconsistent with the idea that Mediterranean diet is associated with lower risk of subsequent incident dementia.

  60. 聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

    白倉 真之, 川瀬 哲明, 菅野 彰剛, 太田 淳, 中里 信和, 川島 隆太, 香取 幸夫

    臨床神経生理学　49　(5)　440-440　2021/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  61. 聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

    白倉 真之, 川瀬 哲明, 菅野 彰剛, 太田 淳, 中里 信和, 川島 隆太, 香取 幸夫

    臨床神経生理学　49　(5)　440-440　2021/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  62. Subjective hearing handicap is associated with processing speed and visuospatial performance in older adults without severe hearing handicap

    Natasha Y.S. Kawata, Rui Nouchi, Toshiki Saito, Ryuta Kawashima

    Experimental Gerontology　111614-111614　2021/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.exger.2021.111614 　

    ISSN： 0531-5565

  63. Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex. International-journal

    Hikaru Takeuchi, Ryosuke Kimura, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Sugiko Hanawa, Kunio Iizuka, Atsushi Sekiguchi, Tsuyoshi Araki, Carlos Makoto Miyauchi, Shigeyuki Ikeda, Kohei Sakaki, Kelssy H Dos S Kawata, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Tadashi Imanishi, Ryuta Kawashima

    Human brain mapping　42　(18)　6028-6037　2021/09/29

    DOI： 10.1002/hbm.25667 　

    More details Close

    It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD-PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole-brain voxel-by-voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD-PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD-PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD-PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals.

  64. The influence of NRXN1 on systemizing and the brain structure in healthy adults

    Yuka Shiota, Izumi Matsudaira, Hikaru Takeuchi, Chiaki Ono, Hiroaki Tomita, Ryuta Kawashima, Yasuyuki Taki

    Brain Imaging and Behavior　16　(2)　692-701　2021/09/16

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11682-021-00530-8 　

    ISSN： 1931-7557

    eISSN： 1931-7565

  65. Magnetoencephalography to confirm epileptiform discharges mimicking small sharp spikes in temporal lobe epilepsy. International-journal

    Dai Agari, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Makoto Ishida, Ryuta Kawashima, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　132　(8)　1785-1789　2021/08

    DOI： 10.1016/j.clinph.2021.03.049 　

    More details Close

    OBJECTIVE: To determine whether magnetoencephalography (MEG) can identify epileptiform discharges mimicking small sharp spikes (SSSs) on scalp electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE). METHODS: We retrospectively reviewed simultaneous scalp EEG and MEG recordings of 83 consecutive patients with TLE and 49 with extra-TLE (ETLE). RESULTS: SSSs in scalp EEG were detected in 15 (18.1%) of 83 TLE patients compared to only two (4.1%) of 49 ETLE patients (p = 0.029). Five of the 15 TLE patients had MEG spikes with concurrent SSSs in EEG, but neither of the 2 ETLE patients. Three of these 5 TLE patients had additional interictal epileptiform discharges (IEDs) in EEG and MEG. Equivalent current dipoles (ECDs) of MEG spikes with concurrent SSSs and IEDs showed no difference in temporal lobe localization and horizontal orientation, whereas ECD moments were smaller in MEG spikes with concurrent SSSs than those with IEDs. CONCLUSIONS: SSSs were more common in TLE than in ETLE. At least some morphologically diagnosed SSSs are true but low-amplitude epileptiform discharges in TLE which can be identified with simultaneous MEG. SIGNIFICANCE: Simultaneous MEG is useful to identify epileptiform discharges mimicking SSSs in patients with TLE.

  66. Lead exposure is associated with functional and microstructural changes in the healthy human brain. International-journal

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susum Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

    Communications biology　4　(1)　912-912　2021/07/26

    DOI： 10.1038/s42003-021-02435-0 　

    More details Close

    Lead is a toxin known to harm many organs in the body, particularly the central nervous system, across an individual's lifespan. To date, no study has yet investigated the associations between body lead level and the microstructural properties of gray matter areas, and brain activity during attention-demanding tasks. Here, utilizing data of diffusion tensor imaging, functional magnetic resonance imaging and cognitive measures among 920 typically developing young adults, we show greater hair lead levels are weakly but significantly associated with (a) increased working memory-related activity in the right premotor and pre-supplemental motor areas, (b) lower fractional anisotropy (FA) in white matter areas near the internal capsule, (c) lower mean diffusivity (MD) in the dopaminergic system in the left hemisphere and other widespread contingent areas, and (d) greater MD in the white matter area adjacent to the right fusiform gyrus. Higher lead levels were also weakly but significantly associated with lower performance in tests of high-order cognitive functions, such as the psychometric intelligence test, greater impulsivity measures, and higher novelty seeking and extraversion. These findings reflect the weak effect of daily lead level on the excitability and microstructural properties of the brain, particularly in the dopaminergic system.

  67. Benefits of VR Physical Exercise on Cognition in Older Adults with and without Mild Cognitive Decline: A Systematic Review of Randomized Controlled Trials

    Kohei Sakaki, Rui Nouchi, Yutaka Matsuzaki, Toshiki Saito, Jérôme Dinet, Ryuta Kawashima

    Healthcare　9　(7)　883-883　2021/07/13

    Publisher: MDPI AG

    DOI： 10.3390/healthcare9070883 　

    eISSN： 2227-9032

    More details Close

    It is well known that physical exercise has beneficial effects on cognitive function in older adults. Recently, several physical exercise programs with virtual reality (VR) have been proposed to support physical exercise benefits. However, it is still unclear whether VR physical exercise (VR-PE) has positive effects on cognitive function in older adults. The purpose of this study was to conduct a systematic review (SR) of the effects of VR-PE on cognitive function in older adults with and without cognitive decline. We used academic databases to search for research papers. The criteria were intervention study using any VR-PE, participants were older adults with and without mild cognitive decline (not dementia), and cognitive functions were assessed. We found that 6 of 11 eligible studies reported the significant benefits of the VR-PE on a wide range of cognitive functions in aging populations. The SR revealed that VR-PE has beneficial effects on the inhibition of executive functions in older adults with and without mild cognitive decline. Moreover, VR-PE selectively leads to improvements in shifting and general cognitive performance in healthy older adults. The SR suggests that VR-PE could be a successful approach to improve cognitive function in older adults with and without cognitive decline.

  68. Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchid, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Ryuta Kawashima

    Journal of Psychosomatic Research　149　110590-110590　2021/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.jpsychores.2021.110590 　

    ISSN： 0022-3999

  69. Neural Evidence of Language Membership Control in Bilingual Word Recognition: An fMRI Study of Cognate Processing in Chinese–Japanese Bilinguals

    Ming-Che Hsieh, Hyeonjeong Jeong, Motoaki Sugiura, Ryuta Kawashima

    Frontiers in Psychology　12　2021/06/07

    Publisher: Frontiers Media SA

    DOI： 10.3389/fpsyg.2021.643211 　

    eISSN： 1664-1078

    More details Close

    This study aims to examine the neural mechanisms of resolving response competition during bilingual word recognition in the context of language intermixing. During fMRI scanning, Chinese–Japanese unbalanced bilinguals were required to perform a second-language (L2) lexical decision task composed of cognates, interlingual homographs, matched control words from both Chinese (first language) and Japanese (L2), and pseudowords. Cognate word processing showed longer reaction times and greater activation in the supplementary motor area (SMA) than L2 control word processing. In light of the orthographic and semantic overlap of cognates, these results reflect the cognitive processing involved in resolving response conflicts enhanced by the language membership of non-target language during bilingual word recognition. A significant effect of L2 proficiency was also observed only in the SMA, which is associated with the task decision system. This finding supports the bottom-up process in the BIA+ model and the Multilink model. The task/decision system receives the information from the word identification system, making appropriate responses during bilingual word recognition.

  70. Prefrontal Inter-brain Synchronization Reflects Convergence and Divergence of Flow Dynamics in Collaborative Learning: A Pilot Study

    Takayuki Nozawa, Mutsumi Kondo, Reiko Yamamoto, Hyeonjeong Jeong, Shigeyuki Ikeda, Kohei Sakaki, Yoshihiro Miyake, Yasushige Ishikawa, Ryuta Kawashima

    Frontiers in Neuroergonomics　2　2021/06/03

    Publisher: Frontiers Media SA

    DOI： 10.3389/fnrgo.2021.686596 　

    eISSN： 2673-6195

    More details Close

    Flow is a highly motivated and affectively positive state in which a person is deeply engaged in an activity and feeling enjoyment from it. In collaborative activities, it would be optimal if all participants were in a state of flow. However, flow states fluctuate amongst individuals due to differences in the dynamics of motivation and cognition. To explore the possibility that inter-brain synchronization can provide a quantitative measure of the convergence and divergence of collective motivational dynamics, we conducted a pilot study to investigate the relationship between inter-brain synchronization and the interpersonal similarity of flow state dynamics during the collaborative learning process. In two English as a Foreign Language (EFL) classes, students were divided into groups of three-four and seated at desks facing each other while conducting a 60-min group work. In both classes, two groups with four members were randomly selected, and their medial prefrontal neural activities were measured simultaneously using wireless functional near-infrared spectroscopy (fNIRS) devices. Later the participants observed their own activities on recorded videos and retrospectively rated their subjective degree of flow state on a seven-point scale for each 2-min period. For the pairs of students whose neural activities were measured, the similarity of their flow experience dynamics was evaluated by the temporal correlation between their flow ratings. Prefrontal inter-brain synchronization of the same student pairs during group work was evaluated using wavelet transform coherence. Statistical analyses revealed that: (1) flow dynamics were significantly more similar for the student pairs within the same group compared to the pairs of students assigned across different groups; (2) prefrontal inter-brain synchronization in the relatively short time scale (9.3–13.9 s) was significantly higher for the within-group pairs than for the cross-group pairs; and (3) the prefrontal inter-brain synchronization at the same short time scale was significantly and positively correlated with the similarity of flow dynamics, even after controlling for the effects of within- vs. cross-group pair types from the two variables. These suggest that inter-brain synchronization can indeed provide a quantitative measure for converging and diverging collective motivational dynamics during collaborative learning, with higher inter-brain synchronization corresponding to a more convergent flow experience.

  71. Brain Microstructural Properties Related to Subjective Well-Being: Diffusion Tensor Imaging Analysis. International-journal

    Chiaki Terao Maeda, Hikaru Takeuchi, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Ikeda Shigeyuki, Susumu Yokota, Daniele Magistro, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

    Social cognitive and affective neuroscience　16　(10)　1079-1090　2021/05/14

    DOI： 10.1093/scan/nsab063 　

    More details Close

    Although it is known that health is not merely the absence of disease, the positive aspects of mental health have been less comprehensively researched compared with its negative aspects. Subjective well-being is one of the indicators of positive psychology, and high subjective well-being is considered to benefit individuals in multiple ways. However, the neural mechanisms underlying individual differences in subjective well-being remain unclear, particularly in terms of brain microstructural properties as detected by diffusion tensor imaging. The present study aimed to investigate the relationship between measurements of diffusion tensor imaging (mean diffusivity and fractional anisotropy) and the degree of subjective well-being as measured using a questionnaire. Voxel-based analysis was used to investigate the association between mean diffusivity and subjective well-being scores in healthy young adults (age, 20.7 ± 1.8 years; 695 males and 514 females). Higher levels of subjective well-being were found to be associated with lower mean diffusivity in areas surrounding the right putamen, insula, globus pallidus, thalamus, and caudate. These results indicated that individual subjective well-being is associated with variability in brain microstructural properties.

  72. Childhood socioeconomic status is associated with psychometric intelligence and microstructural brain development. International-journal

    Hikaru Takeuchi, Yasuyuki Taki, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

    Communications biology　4　(1)　470-470　2021/04/29

    DOI： 10.1038/s42003-021-01974-w 　

    More details Close

    Childhood socioeconomic status is robustly associated with various children's cognitive factors and neural mechanisms. Here we show the association of childhood socioeconomic status with psychometric intelligence and mean diffusivity and fractional anisotropy using diffusion tensor imaging at the baseline experiment (N = 285) and longitudinal changes in these metrics after 3.0 ± 0.3 years (N = 223) in a large sample of normal Japanese children (mean age = 11.2 ± 3.1 years). After correcting for confounding factors, cross-sectional and longitudinal analyses show that higher childhood socioeconomic status is associated with greater baseline and baseline to follow-up increase of psychometric intelligence and mean diffusivity in areas around the bilateral fusiform gyrus. These results demonstrate that higher socioeconomic status is associated with higher psychometric intelligence measures and altered microstructural properties in the fusiform gyrus which plays a key role in reading and letter recognition and further augmentation of such tendencies during development. Definitive conclusions regarding the causality of these relationships requires intervention and physiological studies. However, the current findings should be considered when developing and revising policies regarding education.

  73. Ventral–Dorsal Subregions in the Posterior Cingulate Cortex Represent Pay and Interest, Two Key Attributes of Job Value

    Shunsui Matsuura, Shinsuke Suzuki, Kosuke Motoki, Shohei Yamazaki, Ryuta Kawashima, Motoaki Sugiura

    Cerebral Cortex Communications　2　(2)　2021/04/01

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/texcom/tgab018 　

    eISSN： 2632-7376

    More details Close

    <title>Abstract</title> Career choices affect not only our financial status but also our future well-being. When making these choices, individuals evaluate their willingness to obtain a job (i.e., job values), primarily driven by simulation of future pay and interest. Despite the importance of these decisions, their underlying neural mechanisms remain unclear. In this study, we examined the neural representation of pay and interest. Forty students were presented with 80 job names and asked to evaluate their job values while undergoing functional magnetic resonance imaging (fMRI). Following fMRI, participants rated the jobs in terms of pay and interest. The fMRI data revealed that the ventromedial prefrontal cortex (vmPFC) was associated with job value representation, and the ventral and dorsal regions of the posterior cingulate cortex (PCC) were associated with pay and interest representations, respectively. These findings suggest that the neural computations underlying job valuation conform to a multi-attribute decision-making framework, with overall value signals represented in the vmPFC and the attribute values (i.e., pay and interest) represented in specific regions outside the vmPFC, in the PCC. Furthermore, anatomically distinct representations of pay and interest in the PCC may reflect the differing roles of the two subregions in future simulations.

  74. Intrinsic hippocampal functional connectivity underlying rigid memory in children and adolescents with autism spectrum disorder: A case-control study. International-journal

    Teruo Hashimoto, Susumu Yokota, Yutaka Matsuzaki, Ryuta Kawashima

    Autism : the international journal of research and practice　13623613211004058-13623613211004058　2021/03/28

    DOI： 10.1177/13623613211004058 　

    More details Close

    LAY ABSTRACT: Atypical learning and memory in early life can promote atypical behaviors in later life. Specifically, less relational learning and inflexible retrieval in childhood may enhance restricted and repeated behaviors in patients with autism spectrum disorder. The purpose of this study was to elucidate the mechanisms of atypical memory in children with autism spectrum disorder. We conducted picture-name pair learning and delayed-recognition tests with two groups of youths: one group with high-functioning autism spectrum disorder children (aged 7-16, n = 41) and one group with typically developing children (n = 82) that matched the first group's age, sex, and full-scale IQ. We examined correlations between successful recognition scores and neural connectivity during resting in the magnetic resonance imaging scanner without thinking about anything. Although both learning and retrieval performances were comparable between the two groups, we observed significantly fewer memory gains in the autism spectrum disorder group than in the typically developing group. The memory network was involved in successful memory retrieval in youths with typically developing, while the other memory systems that do not depend to a great degree on networks may be involved in successful memory in youths with autism spectrum disorder. Context-independent and less relational memory processing may be associated with fewer memory gains in autism spectrum disorder. In other words, autism spectrum disorder youths might benefit from non-relational memory. These atypical memory characteristics in autism spectrum disorder may exaggerate their inflexible behaviors in some situations, or-vice versa-their atypical behaviors may result in rigid and less connected memories.

  75. Association Between OLIG2 Gene SNP rs1059004 and Negative Self-Schema Constructing Trait Factors Underlying Susceptibility to Depression

    Hiroshi Komatsu, Hikaru Takeuchi, Chiaki Ono, Zhiqian Yu, Yoshie Kikuchi, Yoshihisa Kakuto, Shunichi Funakoshi, Takashi Ono, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

    Frontiers in Psychiatry　12　2021/03/08

    Publisher: Frontiers Media SA

    DOI： 10.3389/fpsyt.2021.631475 　

    eISSN： 1664-0640

    More details Close

    Recent evidence has indicated that the disruption of oligodendrocytes may be involved in the pathogenesis of depression. Genetic factors are likely to affect trait factors, such as characteristics, rather than state factors, such as depressive symptoms. Previously, a negative self-schema had been proposed as the major characteristic of constructing trait factors underlying susceptibility to depression. Thus, the association between a negative self-schema and the functional single nucleotide polymorphism (SNP) rs1059004 in the <italic>OLIG2</italic> gene, which influences <italic>OLIG2</italic> gene expression, white matter integrity, and cerebral blood flow, was evaluated. A total of 546 healthy subjects were subjected to genotype and psychological evaluation using the Beck Depression Inventory-II (BDI-II) and the Brief Core Schema Scale (BCSS). The rs1059004 SNP was found to be associated with the self-schema subscales of the BCSS and scores on the BDI-II in an allele dose-dependent manner, and to have a predictive impact on depressive symptoms via a negative-self schema. The results suggest the involvement of a genetic factor regulating oligodendrocyte function in generating a negative-self schema as a trait factor underlying susceptibility to depression.

  76. General Intelligence Is Associated with Working Memory-Related Functional Connectivity Change: Evidence from a Large-Sample Study

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

    Brain Connectivity　11　(2)　89-102　2021/03

    DOI： 10.1089/brain.2020.0769 　

    ISSN： 2158-0014

    eISSN： 2158-0022

  77. Brain Structures and Activity During a Working Memory Task Associated with Internet Addiction Tendency in Young Adults

    Saeid Sadeghi, Hikaru Takeuchi, Bita Shalani, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

    2021/02/04

    Publisher: Research Square

    DOI： 10.21203/rs.3.rs-153035/v1 　

    More details Close

    <title>Abstract</title> An increasing number of young people use internet excessively over the last decades, which leads to adverse impacts on individuals and society. The structural and functional brain characteristics associated with the excessive use of the internet have attracted substantial research attention in the past decade; however, due to the small sample sizes of past studies, many findings are inconsistent. Also, the relationship between internet addiction tendency (IAT) and regional brain activity during working memory (WM), a critical cognitive function governing learned behavior, has not been explored. In current study, we used voxel-based morphometry (VBM) and multiple regression analysis to assess the relationship between IAT score and regional gray and white matter volumes (rGMVs and rWMVs) and brain activity during a WM task in a large sample of healthy young adults (n= 1,154, mean age, 20.71 ± 1.78 years).We found a significant positive correlation between IAT score and GMV of right supramarginal gyrus (rSMG) and significant negative correlations with WMVs of right temporal lobe (sub-gyral and superior temporal gyrus), right sublobar area (extra-nuclear and lentiform nucleus), right cerebellar anterior lobe, cerebellar tonsil, right frontal lobe (inferior frontal gyrus and sub-gyral areas), and the pons. Also, IAT was significantly and positively correlated with brain activity in the default-mode network (DMN), medial frontal gyrus, medial part of the superior frontal gyrus, and anterior cingulate cortex) during a 2-back WM task. Moreover, whole-brain analyses of rGMV showed significant effects of interaction between sex and the IAT scores in the area spreading around the left anterior insula and left lentiform. This interaction was moderated by positive correlation in females.These results indicate that IAT is associated with (a) increased GMV in rSMG, which is involved in phonological processing, (b) decreased WMVs in areas of frontal, sublobar, and temporal lobes, which are involved in response inhibition, and (c) reduced task-induced deactivation of the DMN, indicative of altered attentional allocation.

  78. Brain Training and Sulforaphane Intake Interventions Separately Improve Cognitive Performance in Healthy Older Adults, Whereas a Combination of These Interventions Does Not Have More Beneficial Effects: Evidence from a Randomized Controlled Trial

    Rui Nouchi, Qingqiang Hu, Toshiki Saito, Natasha Yuriko dos Santos Kawata, Haruka Nouchi, Ryuta Kawashima

    Nutrients　13　(2)　352-352　2021/01/25

    Publisher: MDPI AG

    DOI： 10.3390/nu13020352 　

    eISSN： 2072-6643

    More details Close

    Background: Earlier studies have demonstrated that a single-domain intervention, such as a brain-training (BT) game alone and a sulforaphane (SFN) intake, positively affects cognition. This study examined whether a combined BT and SFN intake intervention has beneficial effects on cognitive function in older adults. Methods: In a 12-week double-blinded randomized control trial, 144 older adults were randomly assigned to one of four groups: BT with SFN (BT-S), BT with placebo (BT-P), active control game (AT) with SFN (AT-S), and active control game with placebo (AT-P). We used Brain Age in BT and Tetris in AT. Participants were asked to play BT or AT for 15 min a day for 12 weeks while taking a supplement (SFN or placebo). We measured several cognitive functions before and after the intervention period. Results: The BT (BT-S and BT-P) groups showed more improvement in processing speed than the active control groups (AT-S and AT-P). The SFN intake (BT-S and AT-S) groups recorded significant improvements in processing speed and working memory performance unlike the placebo intake groups (BT-P and AT-P). However, we did not find any evidence of the combined intervention’s beneficial effects on cognition. Discussion: We discussed a mechanism to improve cognitive functions in the BT and SFN alone interventions.

  79. N100m latency shortening caused by selective attention. International-journal

    Yuri Nomura, Tetsuaki Kawase, Akitake Kanno, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

    Brain research　1751　147177-147177　2021/01/15

    DOI： 10.1016/j.brainres.2020.147177 　

    More details Close

    The N100m response to a specific same-sound stimulus may be altered by the degree of attention paid to the stimulus. When participants selectively pay attention to the stimulus, the N100m amplitude increases; however, minimal effects are observed on the N100m latency. In this study, we examined the effects of selective special attention (motivation) to extract the frequency (or pitch) information from a probe tone on the N100m response to the probe tone. We compared the N100m latencies and amplitudes using magnetoencephalography, with the following three experimental conditions: 1) vocalization task protocol (vocalize in tune with the pitch of the probe tone after the presentation of the probe tone), 2) hearing task protocol (just listen to the probe tone), and 3) imagining (just imagine the vocalization in tune with the probe tone). The results indicated that the N100m latency in response to the probe tone was significantly shortened in the vocalization and imagining tasks compared with the hearing task in the right hemisphere of the brain. The amplitude was significantly increased in the vocalization task compared with the imagining and hearing tasks in the right hemisphere, and in the vocalization task compared with the hearing task in the left hemisphere of the brain; that is, the attention and/or motivation required to extract the information from the stimulus tones may have caused N100m latency shortening. To our knowledge, this study is the first to demonstrate that the N100m latency may be shortened under particular attentional conditions in response to a simple tone.

  80. Different contra-sound effects between noise and music stimuli seen in N1m and psychophysical responses. International-journal

    Masayuki Shirakura, Tetsuaki Kawase, Akitake Kanno, Jun Ohta, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

    PloS one　16　(12)　e0261637　2021

    DOI： 10.1371/journal.pone.0261637 　

    More details Close

    Auditory-evoked responses can be affected by the sound presented to the contralateral ear. The different contra-sound effects between noise and music stimuli on N1m responses of auditory-evoked fields and those on psychophysical response were examined in 12 and 15 subjects, respectively. In the magnetoencephalographic study, the stimulus to elicit the N1m response was a tone burst of 500 ms duration at a frequency of 250 Hz, presented at a level of 70 dB, and white noise filtered with high-pass filter at 2000 Hz and music stimuli filtered with high-pass filter at 2000 Hz were used as contralateral noise. The contralateral stimuli (noise or music) were presented in 10 dB steps from 80 dB to 30 dB. Subjects were instructed to focus their attention to the left ear and to press the response button each time they heard burst stimuli presented to the left ear. In the psychophysical study, the effects of contralateral sound presentation on the response time for detection of the probe sound of a 250 Hz tone burst presented at a level of 70 dB were examined for the same contra-noise and contra-music used in the magnetoencephalographic study. The amplitude reduction and latency delay of N1m caused by contra-music stimuli were significantly larger than those by contra-noise stimuli in bilateral hemisphere, even for low level of contra-music near the psychophysical threshold. Moreover, this larger suppressive effect induced by contra-music effects was also observed psychophysically; i.e., the change in response time for detection of the probe sound was significantly longer by adding contralateral music stimuli than by adding contra-noise stimuli. Regarding differences in effect between contra-music and contra-noise, differences in the degree of saliency may be responsible for their different abilities to disturb auditory attention to the probe sound, but further investigation is required to confirm this hypothesis.

  81. Brain Activation during Thoughts of One’s Own Death and Its Linear and Curvilinear Correlations with Fear of Death in Elderly Individuals: An fMRI Study

    Kanan Hirano, Kentaro Oba, Toshiki Saito, Shohei Yamazaki, Ryuta Kawashima, Motoaki Sugiura

    Cerebral Cortex Communications　2　(1)　2021/01/01

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/texcom/tgab003 　

    eISSN： 2632-7376

    More details Close

    <title>Abstract</title> Facing one’s own death and managing the fear of death are important existential issues, particularly in older populations. Although recent functional magnetic resonance imaging (fMRI) studies have investigated brain responses to death-related stimuli, none has examined whether this brain activation was specific to one’s own death or how it was related to dispositional fear of death. In this study, during fMRI, 34 elderly participants (aged, 60–72 years) were presented with either death-related or death-unrelated negative words and asked to evaluate the relevance of these words to the “self” or the “other.” The results showed that only the left supplementary motor area (SMA) was selectively activated during self-relevant judgments of death-related words. Regression analyses of the effect of fear of death on brain activation during death-related thoughts identified a significant negative linear correlation in the right supramarginal gyrus (SMG) and an inverted-U-shaped correlation in the posterior cingulate cortex (PCC) only during self-relevant judgments. Our results suggest potential involvement of the SMA in the existential aspect of thoughts of death. The distinct fear-of-death-dependent responses in the SMG and PCC may reflect fear-associated distancing of the physical self and the processing of death-related thoughts as a self-relevant future agenda, respectively.

  82. Brain activity predicts future learning success in intensive second language listening training

    Mayumi Kajiura, Hyeonjeong Jeong, Natasha Y.S. Kawata, Shaoyun Yu, Toru Kinoshita, Ryuta Kawashima, Motoaki Sugiura

    Brain and Language　212　104839-104839　2021/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.bandl.2020.104839 　

    ISSN： 0093-934X

  83. Neural mechanisms of language learning from social contexts

    Hyeonjeong Jeong, Ping Li, Wataru Suzuki, Motoaki Sugiura, Ryuta Kawashima

    Brain and Language　212　104874-104874　2021/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.bandl.2020.104874 　

    ISSN： 0093-934X

  84. Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity. International-journal

    Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Kunio Iizuka, Yuji Takano, Yoshihisa Kakuto, Shunichi Funakoshi, Takashi Ono, Junko Ito, Yasuto Kunii, Mizuki Hino, Atsuko Nagaoka, Yasushi Iwasaki, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Hirotsugu Azechi, Noriko Kudo, Ryota Hashimoto, Hirooki Yabe, Mari Yoshida, Yuko Saito, Akiyoshi Kakita, Nobuo Fuse, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

    Schizophrenia bulletin　46　(6)　1619-1628　2020/12/01

    DOI： 10.1093/schbul/sbaa049 　

    More details Close

    Previous studies have indicated associations between several OLIG2 gene single-nucleotide polymorphisms (SNPs) and susceptibility to schizophrenia among Caucasians. Consistent with these findings, postmortem brain and diffusion tensor imaging studies have indicated that the schizophrenia-risk-associated allele (A) in the OLIG2 SNP rs1059004 predicts lower OLIG2 gene expression in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia patients and reduced white matter (WM) integrity of the corona radiata in normal brains among Caucasians. In an effort to replicate the association between this variant and WM integrity among healthy Japanese, we found that the number of A alleles was positively correlated with WM integrity in some fiber tracts, including the right posterior limb of the internal capsule, and with mean blood flow in a widespread area, including the inferior frontal operculum, orbital area, and triangular gyrus. Because the A allele affected WM integrity in opposite directions in Japanese and Caucasians, we investigated a possible association between the OLIG2 gene SNPs and the expression level of OLIG2 transcripts in postmortem DLPFCs. We evaluated rs1059004 and additional SNPs in the 5' upstream and 3' downstream regions of rs1059004 to cover the broader region of the OLIG2 gene. The 2 SNPs (rs1059004 and rs9653711) had opposite effects on OLIG2 gene expression in the DLPFC in Japanese and Caucasians. These findings suggest ethnicity-dependent opposite effects of OLIG2 gene SNPs on WM integrity and OLIG2 gene expression in the brain, which may partially explain the failures in replicating associations between genetic variants and psychiatric phenotypes among ethnicities.

  85. Awake state-specific suppression of primary somatosensory evoked response correlated with duration of temporal lobe epilepsy

    Makoto Ishida, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato

    Scientific Reports　10　(1)　2020/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-020-73051-x 　

    eISSN： 2045-2322

    More details Close

    <title>Abstract</title> Epilepsy is a network disease. The primary somatosensory cortex (S1) is usually considered to be intact, but could be subclinically disturbed based on abnormal functional connectivity in patients with temporal lobe epilepsy (TLE). We aimed to investigate if the S1 of TLE is abnormally modulated. Somatosensory evoked magnetic fields (SEFs) evoked by median nerve stimulation were recorded in each hemisphere of 15 TLE patients and 28 normal subjects. All responses were separately averaged in the awake state and light sleep using background magnetoencephalography. Latency and strength of the equivalent current dipole (ECD) was compared between the groups for the first (M1) and second peaks. Latencies showed no significant differences between the groups in either wakefulness or light sleep. ECD strengths were significantly lower in TLE patients than in controls only during wakefulness. The reduction of M1 ECD strength in the awake state is significantly correlated with duration of epilepsy. SEFs of TLE patients showed pure ECD strength reduction without latency delay. The phenomenon occurred exclusively during wakefulness, suggesting that a wakefulness-specific modulator of S1 is abnormal in TLE. Repetitive seizures may gradually insult the modulator of S1 distant from the epileptogenic network.

  86. The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity Peer-reviewed

    Hikarua Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Seishu Nakagawa, Kunio Iizuka, Kohei Sakaki, Tsuyoshi Araki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Sugiko Hanawa, Daniele Magistro, Yuka Kotozaki, Yukako Sasaki, Kelssy H. dos S. Kawata, Ryuta Kawashima

    Scientific Reports　10　(1)　2020/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-020-69438-5 　

    eISSN： 2045-2322

    More details Close

    Abstract Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI &lt; 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.

  87. Virtual training leads to physical, cognitive and neural benefits in healthy adults Peer-reviewed

    Dalila Burin, Yingxu Liu, Noriki Yamaya, Ryuta Kawashima

    NeuroImage　222　117297-117297　2020/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.neuroimage.2020.117297 　

    ISSN： 1053-8119

  88. Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

    Hikaru Takeuchi, Hiroaki Tomita, Ryan Browne, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

    Cerebral Cortex　31　(1)　672-680　2020/09/21

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/cercor/bhaa251 　

    ISSN： 1047-3211

    eISSN： 1460-2199

    More details Close

    <title>Abstract</title> The APOE ɛ4 allele is associated with a risk of Alzheimer’s disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex–genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex–genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.

  89. Dorsolateral Prefrontal Cortex Activity during a Brain Training Game Predicts Cognitive Improvements after Four Weeks’ Brain Training Game Intervention: Evidence from a Randomized Controlled Trial

    Rui Nouchi, Natasha Yuriko dos Santos Kawata, Toshiki Saito, Robin Maximilian Himmelmeier, Ryo Nakamura, Haruka Nouchi, Ryuta Kawashima

    Brain Sciences　10　(8)　560-560　2020/08/15

    Publisher: MDPI AG

    DOI： 10.3390/brainsci10080560 　

    eISSN： 2076-3425

    More details Close

    Background: Recent studies have demonstrated that brain activities using NIRS (near-infrared spectroscopy) at baseline during cognitive tasks (e.g., N-back task) can predict the cognitive benefits of a cognitive training. In this study, we investigated whether brain activities during brain training game (BT) at baseline would predict benefits to cognitive functions after the intervention period. Methods: In a four-week double-blinded randomized control trial (RCT) 72 young adults were randomly assigned to one of the two groups: participants in the BT group played specific game, called the Brain Age. Participants in an active control group (ACT) played the puzzle game Tetris. We measured brain activity during the training games using two channel NIRS before the intervention period. Cognitive functions were tested before and after the four-week intervention period. Results: The BT showed significant improvements in inhibition, processing speed, and working memory performance compared to ACT. The left and right DLPFC (dorsolateral prefrontal cortex) brain activities during the BT at baseline were associated with improvements in inhibition and processing speed. Discussion: This randomized control trial first provides scientific evidence that DLPFC activities during BT at baseline can predict cognitive improvements after a four-week intervention period.

  90. Differential roles of amygdala and posterior superior temporal sulcus in social scene understanding Peer-reviewed

    Kentaro Oba, Motoaki Sugiura, Sugiko Hanawa, Mizue Suzuki, Hyeonjeong Jeong, Yuka Kotozaki, Yukako Sasaki, Tatsuo Kikuchi, Takayuki Nozawa, Seishu Nakagawa, Ryuta Kawashima

    Social Neuroscience　1-14　2020/07/21

    Publisher: Informa UK Limited

    DOI： 10.1080/17470919.2020.1793811 　

    ISSN： 1747-0919

    eISSN： 1747-0927

  91. Neural mechanisms underlying concurrent listening of simultaneous speech. International-journal Peer-reviewed

    Natasha Yuriko Santos Kawata, Teruo Hashimoto, Ryuta Kawashima

    Brain research　1738　146821-146821　2020/07/01

    DOI： 10.1016/j.brainres.2020.146821 　

    More details Close

    Can we identify what two people are saying at the same time? Although it is difficult to perfectly repeat two or more simultaneous messages, listeners can report information from both speakers. In a concurrent/divided listening task, enhanced attention and segregation of speech can be required rather than selection and suppression. However, the neural mechanisms of concurrent listening to multi-speaker concurrent speech has yet to be clarified. The present study utilized functional magnetic resonance imaging to examine the neural responses of healthy young adults listening to concurrent male and female speakers in an attempt to reveal the mechanism of concurrent listening. After practice and multiple trials testing concurrent listening, 31 participants achieved performance comparable with that of selective listening. Furthermore, compared to selective listening, concurrent listening induced greater activation in the anterior cingulate cortex, bilateral anterior insula, frontoparietal regions, and the periaqueductal gray region. In addition to the salience network for multi-speaker listening, attentional modulation and enhanced segregation of these signals could be used to achieve successful concurrent listening. These results indicate the presence of a potential mechanism by which one can listen to two voices with enhanced attention to saliency signals.

  92. Association between resting-state functional connectivity and reading in two writing systems in Japanese children with and without developmental dyslexia Peer-reviewed

    Teruo Hashimoto, Hiroki Higuchi, Akira Uno, Susumu Yokota, Kohei Asano, Yasuyuki Taki, Ryuta Kawashima

    Brain Connectivity　2020/06/21

    Publisher: Mary Ann Liebert Inc

    DOI： 10.1089/brain.2020.0759 　

    ISSN： 2158-0014

    eISSN： 2158-0022

  93. A combination of self-reported data and social-related neural measures forecasts viral marketing success on social media Peer-reviewed

    Kosuke Motoki, Shinsuke Suzuki, Ryuta Kawashima, Motoaki Sugiura

    Journal of Interactive Marketing　in press　2020/06

  94. Effects of simultaneously performed dual-task training with aerobic exercise and working memory training on cognitive functions and neural systems in the elderly Peer-reviewed

    Takeuchi H, Magistro D, Kotozaki Y, Motoki K, Kashkouli Nejad K, Nouchi R, Jeong H, Sato C, Salvatore S, Nagatomia R, Zecca M, Takanishi A, Kawashima R

    Neural Plasticity　in press　2020/05

  95. Neural correlates of cognitive bias modification for interpretation. International-journal Peer-reviewed

    Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Ryuta Kawashima

    Social cognitive and affective neuroscience　2020/04/23

    DOI： 10.1093/scan/nsaa026 　

    More details Close

    The effectiveness of cognitive bias modification for interpretation (CBM-I), a treatment method employed to reduce social anxiety (SA), has been examined. However, the neural correlates of CBM-I remain unclear, and we aimed to elucidate brain activities during intervention and activity changes associated with CBM-I effectiveness in a pre-post intervention comparison. Healthy participants divided into two groups (CBM, control) were scanned before, during and after intervention using functional magnetic resonance imaging. Ambiguous social situations followed by positive outcomes were repeatedly imagined by the CBM group during intervention, while half of the outcomes in the control group were negative. Whole-brain analysis revealed that activation of the somatomotor and somatosensory areas, occipital lobe, fusiform gyrus and thalamus during intervention was significantly greater in the CBM than in the control group. Furthermore, altered activities in the somatomotor and somatosensory areas, occipital lobe and posterior cingulate gyrus during interpreting ambiguous social situations showed a significant group × change in SA interaction. Our result suggests that when facing ambiguous social situations, positive imagery instilled by CBM-I is recalled, and interpretations are modified to contain social reward. These findings may help to suggest an alternative manner of enhancing CBM-I effectiveness from a cognitive-neuroscience perspective.

  96. Increased grey matter volume of the right superior temporal gyrus in healthy children with autistic cognitive style: A VBM study

    Akiko Kobayashi, Susumu Yokota, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

    BRAIN AND COGNITION　139　2020/03

    DOI： 10.1016/j.bandc.2019.105514 　

    ISSN： 0278-2626

    eISSN： 1090-2147

  97. 近視を有する緑内障患者の3D T2強調MRIによる眼球形状と体積の定量的解析

    面高 宗子, 舘脇 康子, 檜森 紀子, 津田 聡, 武藤 達士, ティロー・バンジャマン, 松平 泉, 川島 隆太, 瀧 靖之, 中澤 徹

    日本眼科学会雑誌　124　(臨増)　172-172　2020/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  98. Association of iron levels in hair with brain structures and functions in young adults. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)　58　126436-126436　2020/03

    DOI： 10.1016/j.jtemb.2019.126436 　

    More details Close

    BACKGROUND: Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects. METHODS: Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults. RESULTS: Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe. CONCLUSION: These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.

  99. Effects of Lutein and Astaxanthin Intake on the Improvement of Cognitive Functions among Healthy Adults: A Systematic Review of Randomized Controlled Trials. International-journal

    Rui Nouchi, Takahiko Suiko, Eriko Kimura, Hiroki Takenaka, Michiaki Murakoshi, Akira Uchiyama, Megumi Aono, Ryuta Kawashima

    Nutrients　12　(3)　2020/02/27

    DOI： 10.3390/nu12030617 　

    More details Close

    BACKGROUND: Fruits and vegetables are generally rich in antioxidants such as carotenoids. Consumption of carotenoids is expected to have benefits on cognitive functions in humans. However, previous randomized controlled trials (RCT) using carotenoids have reported inconsistent results. Therefore, this systematic review (SR) aimed to summarize the effect of carotenoid intake on cognitive functions in humans. METHOD: PubMed, Cochrane Library, Web of Science, and PsychoINFO were searched for research papers on carotenoid intake with the criteria that 1) oral carotenoid intake was evaluated using RCTs, 2) participants were healthy young, middle-aged, or older, and 3) cognitive functions were measured using RCTs. RESULTS: Five studies using lutein and two studies using astaxanthin met the inclusion criteria. Consumption of lutein and its isomer showed consistent results in selective improvement of visual episodic memory in young and middle-aged adults while inhibition was observed in middle-aged and older adults. One of the two included astaxanthin studies reported a significant improvement of verbal episodic memory performance in middle-aged adults. CONCLUSION: This SR showed that the 10 mg lutein per day for twelve months can lead to improvement of cognitive functions. Due to the small number of studies, it is difficult to conclude whether astaxanthin would have a positive effect on cognitive functions.

  100. Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice. International-journal

    Akira Uruno, Daisuke Matsumaru, Rie Ryoke, Ritsumi Saito, Shiori Kadoguchi, Daisuke Saigusa, Takashi Saito, Takaomi C Saido, Ryuta Kawashima, Masayuki Yamamoto

    Molecular and cellular biology　40　(6)　2020/02/27

    DOI： 10.1128/MCB.00467-19 　

    More details Close

    Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer's disease (AD), AD model AppNL-G-F/NL-G-F knock-in (AppNLGF ) mice were studied in combination with genetic Nrf2 induction model Keap1FA/FA mice. While AppNLGF mice displayed shorter latency to escape than wild-type mice in the passive-avoidance task, the impairment was improved in AppNLGF ::Keap1FA/FA mice. Matrix-assisted laser desorption ionization-mass spectrometry imaging revealed that reduced glutathione levels were elevated by Nrf2 induction in AppNLGF ::Keap1FA/FA mouse brains compared to AppNLGF mouse brains. Genetic Nrf2 induction in AppNLGF mice markedly suppressed the elevation of the oxidative stress marker 8-OHdG and Iba1-positive microglial cell number. We also determined the plasmalogen-phosphatidylethanolamine (PlsPE) level as an AD biomarker. PlsPE containing polyunsaturated fatty acids was decreased in the AppNLGF mouse brain, but Nrf2 induction attenuated this decline. To evaluate whether pharmacological induction of Nrf2 elicits beneficial effects for AD treatment, we tested the natural compound 6-MSITC [6-(methylsulfinyl)hexyl isothiocyanate]. Administration of 6-MSITC improved the impaired cognition of AppNLGF mice in the passive-avoidance task. These results demonstrate that the induction of Nrf2 ameliorates cognitive impairment in the AD model mouse by suppressing oxidative stress and neuroinflammation, suggesting that Nrf2 is an important therapeutic target of AD.

  101. Functional MRI on the ability to handle unexpected events in complex socio-technological systems: task performance and problem-solving characteristics are associated with low activity of the brain involved in problem solving Peer-reviewed

    Naoki Miura, Keito Yoshii, Makoto Takahashi, Motoaki Sugiura, Ryuta Kawashima

    The Transactions of Human Interface Society　22　(1)　43-54　2020/02

    DOI： 10.11184/his.22.1_43 　

  102. Neural substrates underlying skilled spatial information processing of air traffic control operator: an fMRI study Peer-reviewed

    Makoto Takahashi, Kiyokazu Haga, Naoki Miura, Hisae Aoyama, Daisuke Karikawa, Atsushi Sekiguchi, Ryuta Kawashima

    The Transactions of Human Interface Society　22　(1)　35-42　2020/02

    DOI： 10.11184/his.22.1_35 　

  103. Convergent creative thinking performance is associated with white matter structures: Evidence from a large sample study. International-journal Invited Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Izumi Matsudaira, Shigeyuki Ikeda, Kelssy H Dos S Kawata, Rui Nouchi, Kohei Sakaki, Seishu Nakagawa, Takayuki Nozawa, Susumu Yokota, Tsuyoshi Araki, Sugiko Hanawa, Ryo Ishibashi, Shohei Yamazaki, Ryuta Kawashima

    NeuroImage　210　116577-116577　2020/01/22

    DOI： 10.1016/j.neuroimage.2020.116577 　

    More details Close

    In laboratory settings, creativity is measured using tasks of divergent as well as convergent thinking. It has been suggested that brain connectivity is important for creativity. In the present study, we investigated the associations of convergent thinking performance of compound Remote Associates Test (CRAT) with fractional anisotropy (FA) in diffusion tensor imaging and regional white matter (WM) volume (rWMV) in voxel-based morphometry in a large sample of healthy young adults (360 males and 280 females; mean age: 20.9 years, SD ​= ​1.6). We showed that CRAT performance was positively correlated with WM pathway property (i.e., FA) in the left fronto-occipital fasciculus and the left inferior longitudinal fasciculus, which play important roles in processing of language and concept. Further, CRAT performance was negatively correlated with rWMV in the widespread frontal temporal subcortical and cerebellar WM areas, suggesting the unique association of convergent thinking with WM connectivity.

  104. A Single 30 Minutes Bout of Combination Physical Exercises Improved Inhibition and Vigor-Mood in Middle-Aged and Older Females: Evidence From a Randomized Controlled Trial. International-journal

    Rui Nouchi, Haruka Nouchi, Ryuta Kawashima

    Frontiers in aging neuroscience　12　179-179　2020

    DOI： 10.3389/fnagi.2020.00179 　

    More details Close

    Background: Long-term combination of physical exercises has reported benefits for cognitive functions and mood states. However, it remains unclear whether a single bout of combination exercise training has acute positive effects on cognitive functions and mood states in middle-aged and older women. It is important to investigate acute effect of physical exercise because it would help to understand a mechanism of benefits of physical exercise. The purpose of this study was to investigate 30 min of a single bout of combination exercise training on cognition and mood states in middle-aged and older females. Methods: In this single-blinded randomized control trial (RCT), middle-aged and older females were assigned randomly to two groups: a combination exercise group and a no-exercise control group. The former group did the combination exercise training (aerobic, strength, and stretching exercises) for 30 min. Meanwhile, the latter group did not do any exercise and waited for 30 min. We measured cognitive functions and mood performance states before and after the exercise or control interventions. Results: Our main results demonstrated that, compared to the control group, the combination exercise improved inhibition (reverse Stroop and Stroop) and increased vigor-activity mood scores in both middle-aged and older groups. We also found that the only combination exercise group showed the significant positive correlations between improved inhibition performance and improved vigor-activity mood. Discussion: This randomized controlled trial revealed the acute benefits of combination exercise on inhibition in executive functions and vigor-activity in the healthy middle-aged and older females. Our results provided the scientific evidence related to acute effects of the single bout of the combination exercise training. It suggests that we would be better to do the 30 min physical exercise for our health. Clinical Trial Registration: This trial was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN000029681). Registered 24 October 2017, https://upload.umin.ac.jp/cgi-bin/ctr/ctr_view_reg.cgi?recptno=R000033922.

  105. The Role of Cognitive Control in Age-Related Changes in Well-Being. International-journal

    Ayano Yagi, Rui Nouchi, Kou Murayama, Michiko Sakaki, Ryuta Kawashima

    Frontiers in aging neuroscience　12　198-198　2020

    DOI： 10.3389/fnagi.2020.00198 　

    More details Close

    Maintaining emotional well-being in late life is crucial for achieving successful and healthy aging. While previous research from Western cultures has documented that emotional well-being improves as individuals get older, previous research provided mixed evidence on the effects of age on well-being in Eastern Asian cultures. However, previous studies in East Asia do not always take into account the effects of cognitive control-an ability which has been considered as a key to enable older adults to regulate their emotions. In the current study, we tested whether cognitive control abilities interact with age in determining individuals' well-being in 59 Japanese females (age range: 26-79; Mage = 64.95). Participants' mental health and mental fatigue were tracked for 5 years together with their cognitive control abilities. We found that as individuals became older, they showed improved mental health and decreased mental fatigue. In addition, we found a quadratic effect of age on mental fatigue, which was further qualified by baseline cognitive control abilities. Specifically, in those who had a lower level of cognitive control abilities, mental fatigue declined until the mid-60s, at which point it started increasing (a U-shape effect). In contrast, in those who had a higher level of cognitive control ability, mental fatigue showed a steady decrease with age even after their mid-60s. These results suggest that whether advancing age is associated with positive vs. negative changes in well-being depends on cognitive control abilities, and that preserved cognitive control is a key to maintain well-being in late life.

  106. A single nucleotide polymorphism (-250 A/C) of the GFAP gene is associated with brain structures and cerebral blood flow. International-journal

    Yuta Takahashi, Hikaru Takeuchi, Mai Sakai, Zhiqian Yu, Yoshie Kikuchi, Fumiaki Ito, Hiroo Matsuoka, Osamu Tanabe, Jun Yasuda, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

    Psychiatry and clinical neurosciences　74　(1)　49-55　2020/01

    DOI： 10.1111/pcn.12932 　

    More details Close

    AIM: Glial fibrillary acidic protein (GFAP), the intermediate filament protein expressed in astrocytes, plays a key role in many aspects of brain function through communication with neurons or blood vessels. A common single nucleotide polymorphism (SNP), GFAP -250 C/A (rs2070935), is associated with the transcriptional regulation of GFAP, which can potentially result in the genotype-specific brain structure. This study aimed to verify the biological effects of the GFAP variants on brain structure and function. METHODS: We investigated the associations between the GFAP variants and magnetic resonance imaging findings, including gray and white matter volumes, white matter integrity, and resting arterial blood flow, from 1212 healthy Japanese subjects. RESULTS: The GFAP -250 C/A genotype was significantly associated with total gray matter volume, total white matter volume, average mean diffusivity, and mean cerebral blood flow. In voxel-by-voxel analyses, the GFAP genotype showed significant associations with the regional gray and white matter volumes in the inferior frontal lobe and corpus callosum, the regional mean diffusivity in the left posterior region, and the regional cerebral blood flow throughout the brain. CONCLUSION: This study revealed a common SNP that is significantly associated with multiple global brain structure parameters.

  107. MEGによるてんかん研究 up-to-date 覚醒時の体性感覚誘発磁界第1波の信号強度抑制は側頭葉てんかんの罹病期間と相関する

    石田 誠, 神 一敬, 柿坂 庸介, 菅野 彰剛, 川島 隆太, 中里 信和

    日本生体磁気学会誌　33　(1)　62-63　2020

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  108. 口唇裂手術後の口唇感覚に関する体性感覚誘発磁界を用いた客観的評価

    北山 ちひろ, 菅野 彰剛, 日原 大貴, 島田 栄理遣, 金高 弘恭, 中里 信和, 川島 隆太, 五十嵐 薫

    日本生体磁気学会誌　33　(1)　161-163　2020

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  109. Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms Peer-reviewed

    Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Kotozaki Y, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakaki K, Nozawa T, Ikeda S, Yokota S, Magistro D, Sassa Y, Kawashima R

    Scientific Reports　in press　2020

  110. Effects of training of shadowing and reading aloud of second language on working memory and neural systems Peer-reviewed

    Takeuchi H, Maruyama T, Taki Y, Motoki K, Jeong H, Kotozaki Y, Shinada T, Nakagawa S, Nouchi R, Iizuka K, Yokoyama R, Yamamoto Y, Hanawa S, Araki T, Sakaki K, Sasaki Y, Magistro D, Kawashima R

    Brain Imaging and Behavior　in press　2020

  111. Somatosensory evoked magnetic fields of periodontal mechanoreceptors. International-journal Peer-reviewed

    Hiroki Hihara, Hiroyasu Kanetaka, Akitake Kanno, Eriya Shimada, Satoko Koeda, Ryuta Kawashima, Nobukazu Nakasato, Keiichi Sasaki

    Heliyon　6　(1)　e03244　2020/01

    DOI： 10.1016/j.heliyon.2020.e03244 　

    More details Close

    To evaluate the localization of responses to stimulation of the periodontal mechanoreceptors in the primary somatosensory cortex, somatosensory evoked fields (SEFs) were measured for stimulation of the left mandibular canine and first molar using magnetoencephalography in 25 healthy subjects. Tactile stimulation used a handmade stimulus device which recorded the trigger at the moment of touching the teeth.SEFs for the canine and first molar were detected in 20 and 19 subjects, respectively. Both responses were detected in the bilateral hemispheres. The latency for the canine was 62.1 ± 12.9 ms in the ipsilateral hemisphere and 65.9 ± 14.8 ms in the contralateral hemisphere. The latency for the first molar was 47.4 ± 6.6 ms in the ipsilateral hemisphere and 47.8 ± 9.1 ms in the contralateral hemisphere. The latency for the first molar was significantly shorter than that for the canine. The equivalent current dipoles were estimated in the central sulcus and localized anteroinferiorly compared to the locations for the SEFs for the median nerve. No significant differences in three-dimensional coordinates were found between the canine and first molar. These findings demonstrate the precise location of the teeth within the orofacial representation area in the primary somatosensory cortex.

  112. Originality of divergent thinking is associated with working memory–related brain activity: evidence from a large sample study Peer-reviewed

    Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Kotozaki Y, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakak K, Sassa Y, Nozawa T, Ikeda S, Yokota S, Magistro D, Kawashima R

    Neuroimage　in press　2020

  113. Loneliness modulates automatic attention to warm and competent faces: Preliminary evidence from an eye-tracking study International-journal Peer-reviewed

    Saito Toshiki, Motoki Kosuke, Rui Nouchi, Ryuta Kawashima, Sugiura Motoaki

    Frontiers in Psychology　10　2967-2967　2020/01

    DOI： 10.3389/fpsyg.2019.02967 　

    ISSN： 1664-1078

    More details Close

    Social connections are essential for human survival. Loneliness is a motivational factor for building and maintaining social connections. Automatic attention occurs with little cognitive effort and plays a key role in detecting biologically salient events, such as human faces. Although previous studies have investigated the effect of loneliness on social behavior, the effect of loneliness on automatic attention to human faces remains largely unknown. The present study investigated the effects of loneliness on automatic visual attention to warmth and competence facial information, which determines facial attraction. This study included 43 participants who rated warmth and competence facial information. Then, they engaged with the target-distractor paradigm in which they saw two house images at the top and bottom and indicated whether the images were identical. During the task, we presented two faces as distractors and measured visual attention toward the faces as automatic attention because participants did not have to attend to the faces. The results showed an interactive effect between subjective loneliness and facial information on automatic attention. Warm targets automatically captured the attention of people feeling relatively lonely, whereas competent targets automatically captured the attention of those who felt less lonely. These results suggest that loneliness adaptively influences automatic processing of social information.

  114. Virtual training leads to real acute physical, cognitive, and neural benefits on healthy adults: study protocol for a randomized controlled trial

    Dalila Burin, Noriki Yamaya, Rie Ogitsu, Ryuta Kawashima

    Trials　20　(1)　2019/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s13063-019-3591-1 　

    eISSN： 1745-6215

    More details Close

    <title>Abstract</title><sec><title>Background</title>Keeping a certain level of physical activity has beneficial effects on the body itself but also, surprisingly, on cognition: specifically, physical high-intensity intermittent aerobic exercise (HIE) can show improvement on cognitive executive functions. Although, in some cases performing strength or aerobic training is problematic or not feasible. Immersive virtual reality (IVR) can induce the illusory feeling of ownership and agency over a moving virtual body, therefore showing comparable physiological reactions: for example, if an individual is sitting on a chair but his virtual body climbs a hill, the individual’s heart rate increases coherently, as if he is actually walking. In this study, we investigate whether this same illusion can show beneficial consequences on the body as well as on executive functions (using the color-word matching Stroop task) and on its neural substrates (using functional near-infrared spectroscopy [fNIRS]). </sec><sec><title>Methods</title>In a cross-over randomized controlled trial, 30 healthy young adults will experience HIE training in IVR (i.e. the virtual body will perform eight sets of 30 s of running followed by 30 s of slow walking, while the participant is completely still) according to two random-ordered conditions: during the experimental condition, the virtual body is displayed in first-person perspective (1PP), while in the control condition, the virtual body is displayed in third-person perspective (3PP). To confirm that individuals have the illusion of ownership and agency over the virtual body in 1PP (and not in 3PP), we will record the heart rate, in addition to subjective questionnaires. Before and after every IVR sessions (one week apart), we will measure cortical hemodynamic changes in the participants’ prefrontal cortex using the fNIRS device during the Stroop task’s execution. </sec><sec><title>Discussion</title>From a theoretical perspective, we could prove that the sense of body ownership and agency can modulate physical and cognitive parameters, even in the absence of actual movements; from a clinical perspective, these results could be useful to train cognition and body simultaneously, in a completely safe environment. </sec><sec><title>Trial registration</title>University Hospital Medical Information Network Clinical Trial Registry,<ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000039052">UMIN000034255</ext-link>. Registered on 1 October 2018. </sec>

  115. The pitfall of empathic concern with chronic fatigue after a disaster in young adults. International-journal Peer-reviewed

    Seishu Nakagawa, Motoaki Sugiura, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Sugiko Hanawa, Tsuyoshi Araki, Atsushi Sakuma, Ryuta Kawashima

    BMC psychiatry　19　(1)　338-338　2019/11/04

    DOI： 10.1186/s12888-019-2323-0 　

    More details Close

    BACKGROUND: Empathic concern (EC) is an important interpersonal resilience factor that represents positive adaptation, such as "relating to others" (a factor of posttraumatic growth [PTG]) after disaster. However, controversy exists regarding whether the changes in EC (e.g., the intra-personal change between the acute phase and the disillusionment phase) positively or negatively affect mental health after a disaster. We hypothesized that increased EC may increase chronic fatigue due to over-adjustment (hypothesis 1). We also hypothesized that increasing the changes in "relating to others" could decrease the changes in chronic fatigue (hypothesis 2). METHODS: Forty-nine young, healthy volunteers (M/F: 36/13; age at 3 months after the disaster [3 months]: mean ± SD: 21.1 ± 1.7 years) underwent assessments of EC using the Japanese version of the Interpersonal Reactivity Index, chronic fatigue using the Japanese version of the Checklist Individual Strength (CIS-J) questionnaire, and "relating to others" using the Japanese version of the PTG inventory during the acute phase (3 months) and the disillusionment phase (1 year after the disaster). Pearson product moment correlations at 3 months and 1 year were determined for all scores related to EC. The changes (delta = degree of change from 3 months to 1 year) or scores at 1 year were entered into linear structural equation systems to test the hypotheses. RESULTS: The delta of EC positively affected the delta of the CIS-J, and the delta of relating to others negatively affected the delta of the CIS-J. Both the EC and relating to others scores were negatively associated with the CIS-J score at 1 year. These results were in accordance with hypothesis 1 and 2. CONCLUSIONS: We demonstrated the opposite effects of 2 types of ECs, i.e., stability (inherent disposition) and flexibility (degree of change), on the degree of chronic fatigue. Increasing EC with increasing chronic fatigue, but not the change in relating to others, may be a red flag for individuals during the disillusionment phase.

  116. Corrigendum to "Anxiety increases visual attention to hedonic foods: A preliminary eye-tracking study on the impact of the interplay between integral and incidental affect on foods" [Appetite 137 (1 June 2019) 218-225]. International-journal

    Kosuke Motoki, Toshiki Saito, Rui Nouchi, Ryuta Kawashima, Motoaki Sugiura

    Appetite　142　104400-104400　2019/11/01

    DOI： 10.1016/j.appet.2019.104400 　

  117. Predicting hazard perception performance from brain activity. An fMRI experiment using driving simulator

    Oba K, Hamada K, Hirose M, Kawashima R, Sugiura M

    1108　2019/11

  118. Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images. International-journal Peer-reviewed

    Yasuko Tatewaki, Tatsushi Mutoh, Kazuko Omodaka, Benjamin Thyreau, Izumi Matsudaira, Hiroaki Furukawa, Keiji Yamada, Keiko Kunitoki, Ryuta Kawashima, Toru Nakazawa, Yasuyuki Taki

    Scientific reports　9　(1)　15148-15148　2019/10/22

    DOI： 10.1038/s41598-019-51611-0 　

    More details Close

    Elongated axial length of the eye increases the morbidity of glaucoma. Myopia also associates with elongated axial length, and such ellipsoid shape of the eyeball strongly contributes its pathogenesis. Morphological features of the eyeballs, which could be important factors for developing glaucoma, have not been well described. The aim of this study was to investigate the three-dimensional (3D) topographic features of glaucomatous eyeballs with/without myopia to evaluate the potential of those features for predicting glaucoma. Using a 3.0-tesla MRI, volume-isotropic turbo-spin-echo acquisition T2-weighted images were obtained from 55 patients with glaucoma and 22 controls to delineate the eyeballs. Eyeball volumes, axial lengths and transverse lengths were semi-automatically calculated and compared between four groups: normal, myopia, glaucoma, and glaucoma with myopia. Both glaucoma and myopia increased the eyeball volume compared to the normal eyes. An increased anisotropy ratio (axial/transversus length) was observed in myopic eyes compared to normal, whereas in the glaucomatous eyes, with or without myopia, no increase in anisotropy ratio was observed. Increasing volume of eyes can be caused by myopia and glaucoma. Myopic eyes were ellipsoid in shape, but there was less anisotropy and a near-spherical shape in glaucomatous eyes, even in glaucomatous myopic eyes.

  119. Common neural value representations of hedonic and utilitarian products in the ventral striatum: An fMRI study Peer-reviewed

    Motoki K, Sugiura M, Kawashima R

    Scientific Reports　2019/10

  120. Does Video Gaming Have Impacts on the Brain: Evidence from a Systematic Review. International-journal

    Denilson Brilliant T, Rui Nouchi, Ryuta Kawashima

    Brain sciences　9　(10)　2019/09/25

    DOI： 10.3390/brainsci9100251 　

    More details Close

    Video gaming, the experience of playing electronic games, has shown several benefits for human health. Recently, numerous video gaming studies showed beneficial effects on cognition and the brain. A systematic review of video gaming has been published. However, the previous systematic review has several differences to this systematic review. This systematic review evaluates the beneficial effects of video gaming on neuroplasticity specifically on intervention studies. Literature research was conducted from randomized controlled trials in PubMed and Google Scholar published after 2000. A systematic review was written instead of a meta-analytic review because of variations among participants, video games, and outcomes. Nine scientific articles were eligible for the review. Overall, the eligible articles showed fair quality according to Delphi Criteria. Video gaming affects the brain structure and function depending on how the game is played. The game genres examined were 3D adventure, first-person shooting (FPS), puzzle, rhythm dance, and strategy. The total training durations were 16-90 h. Results of this systematic review demonstrated that video gaming can be beneficial to the brain. However, the beneficial effects vary among video game types.

  121. Prior physical synchrony enhances rapport and inter-brain synchronization during subsequent educational communication. Peer-reviewed

    Nozawa T, Sakaki K, Ikeda S, Jeong H, Yamazaki S, Kawata KHDS, Kawata NYDS, Sasaki Y, Kulason K, Hirano K, Miyake Y, Kawashima R

    Scientific reports　9　(1)　12747　2019/09

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-019-49257-z 　

    eISSN： 2045-2322

  122. Mean diffusivity associated with trait emotional intelligence. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

    Social cognitive and affective neuroscience　14　(8)　871-883　2019/08/31

    DOI： 10.1093/scan/nsz059 　

    ISSN： 1749-5016

    More details Close

    Previous neuroimaging studies have suggested that the neural bases of trait emotional intelligence (TEI) lie in the social cognition network (SCN) and the somatic marker circuitry (SMC). The current study was the first to investigate the associations of total TEI factors and subfactors with mean diffusivity (MD) of these networks as well as regional MD of the dopaminergic system (MDDS). We found that TEI intrapersonal factor score and total TEI score were negatively correlated with regional MDDS in the vicinity of the right putamen and right pallidum and that TEI intrapersonal factor score was negatively correlated with MD values of the fusiform gyrus. Total TEI score and TEI factor scores were positively correlated with MD values of various areas within or adjacent to SCN components, SMC structures and the lateral prefrontal cortex (LPFC). Our MD findings demonstrated the importance of the dopaminergic system to TEI and implicate the SCN, SMC and LPFC in TEI. Future studies are required to investigate the implications of positive and negative associations with MD values.

  123. Mean diffusivity related to rule-breaking guilt: the Macbeth effect in the sensorimotor regions. International-journal Peer-reviewed

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

    Scientific reports　9　(1)　12227-12227　2019/08/22

    DOI： 10.1038/s41598-019-48654-8 　

    More details Close

    Guilt, a self-conscious emotion, includes self-focused role taking and also correlates with other-oriented role-taking. Excess guilt proneness might be relevant to obsessive compulsive disorders. The white matter (WM) neural correlates of the degree of guilt have not yet been determined. We hypothesized that the WM structures involved in feelings of guilt are associated with social and moral cognition (inferior parietal lobule [IPL], prefrontal cortex [PFC], and cingulate), and aimed to visualize this using diffusion MRI. We investigated the association between regional WM structures (WM volume, and fractional anisotropy, and mean diffusivity [MD]), and feelings of guilt in 1196 healthy, young students using MRI and the Guilty Feeling Scale, which comprises interpersonal situation (IPS; guilt from hurting friends) and rule-breaking situation (RBS; deontological guilt) scores. The primary novel finding presented here is that MD in the right somatosensory and motor cortices from arm to hand were positively correlated with RBS scores. Further, consistent with our hypothesis, RBS scores were positively correlated with MD in the same regions. These results would be predicted by the Macbeth effect, an obsession with dirt leading to hand-washing rituals resulting from guilt, made famous by the Shakespearian character Lady Macbeth. "What, will these hands ne'er be clean?" William Shakespeare (Shakespeare, 1606) Macbeth.

  124. Does Incidental Pride Increase Competency Evaluation of Others Who Appear Careless? Discrete Positive Emotions and Impression Formation International-journal Peer-reviewed

    Saito Toshiki, Motoki Kosuke, Rui Nouchi, Ryuta Kawashima, Sugiura Motoaki

    PLOS ONE　14　(8)　e0220883　2019/08

    DOI： 10.1371/journal.pone.0220883 　

    More details Close

    Emotion plays important and diverse roles across various social relations. Although the social functions of emotion have attracted increased attention, the effects of positive emotions such as pride on impression formation remain poorly understood. Drawing on social projection theory, this study examined how incidental experiences of pride influenced the impressions of those who made a blunder, along with two other characteristics: the person's warmth and competence. Participants were designated randomly to receive inductions of pride, awe, or a neutral emotion. Subsequently, they were asked to indicate their own impression of a person who had made a blunder and to rate their overall sense of that individual's warmth and competence. A laboratory experiment recruiting university students (Study 1, N = 79) demonstrated that pride, a positive emotion elicited by a self-relevant achievement, led to higher competency evaluations of others. However, a pre-registered online experiment in middle-aged adults (Study 2, N = 108) failed to replicate the effects of pride on competency evaluations of others. Furthermore, another pre-registered online experiment in younger adults (Study 3, N = 290) did not show successful manipulation of incidental emotions. These results suggest that strictly controlled experimental settings that induce robust incidental emotions might be better for demonstrating a strong pride effect on the evaluation of others.

  125. A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity. International-journal Peer-reviewed

    Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

    Cerebral cortex (New York, N.Y. : 1991)　29　(8)　3211-3219　2019/07/22

    DOI： 10.1093/cercor/bhy189 　

    ISSN： 1047-3211

    More details Close

    Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we investigated the sex-specific effects of the CACNA1C variant rs1024582 on psychiatry-related traits, brain activity during tasks and rest, and brain volume in 1207 normal male and female subjects. After correcting for multiple comparisons, there were significant interaction effects between sex and the minor allele of this polymorphism on the hostile behavior subscale scores of the Coronary-Prone Type Scale mediated by higher scores in female carriers of the minor allele. Imaging analyses revealed significant interaction effects between sex and the minor allele on fractional amplitude of low-frequency fluctuations in the right dorsolateral prefrontal cortex and on brain activity during the 2-back task in areas of the right posterior cingulate cortex, right thalamus, and right hippocampus, which were all mediated by reduced activity in female carriers of the minor allele. Our results demonstrated that the rs1024582 risk variant of CACNA1C is associated with reduced activity in the frontolimbic regions at rest and during a working memory task as well as with greater hostility in females in the healthy population.

  126. Neural responses to action contingency error in different cortical areas are attributable to forward prediction or sensory processing International-journal Peer-reviewed

    Kikuchi Tatsuo, Sugiura Motoaki, Yamamoto Yuki, Sasaki Yukako, Hanawa Sugiko, Sakuma Atsushi, Matsumoto Kazunori, Matsuoka Hiroo, Kawashima Ryuta

    SCIENTIFIC REPORTS　9　(1)　9847-9847　2019/07/08

    DOI： 10.1038/s41598-019-46350-1 　

    ISSN： 2045-2322

  127. Hybrid magneto-fluorescent nano-probe for live apoptotic cells monitoring at brain cerebral ischemia. International-journal Peer-reviewed

    Moataz M Mekawy, Atsushi Saito, Akira Sumiyoshi, Jorge J Riera, Hiroaki Shimizu, Ryuta Kawashima, Teiji Tominaga

    Materials science & engineering. C, Materials for biological applications　100　485-492　2019/07

    DOI： 10.1016/j.msec.2019.03.032 　

    More details Close

    α-Fe2O3 Magnetic nanoparticles (MNPs) have been synthesized, functionalized at silica that ends up with -NH2 group to form FMNPs. Conjugation of FMNPs with a fluorescently-labeled poly-caspase inhibitor valylalanylaspartic acid fluoromethyl ketone (SR-FLICA) which serves as a pan-caspase inhibitor was carried out to form finally a hybrid probe SR-FLICA-FMNPs. This probe could be used as a multimodal magneto-fluorescent platform for live apoptotic cells monitoring using MR and fluorescence imaging techniques. Characterization results of the as-synthesized MNPs and functionalized FMNPs by SEM, TEM, N2 isotherm, XRD and magnetic VSM showed that, a controlled morphological structure of MNPs could be synthesized with cubic-shaped, ferromagnetic, base-centered orthorhombic space group R3c and average size of 45.8 ± 3.2 and 50.3 ± 1.6 nm for MNPs and FMNPs, respectively. Phantom MRI experimental results of the examined MNPs and FMNPs confirmed the concentration dependency nature of T2 signal reduction. In addition, in vitro and in vivo sensing studies on our conjugated hybrid multifunctional probe SR-FLICA-FMNPs using 9 L gliosarcoma cells confirmed that; it could positively intact within the astrocytes and the nuclei of the apoptotic cells taking into account the starting material's cytotoxicity. Several histo-chemical protocols could be examined to confirm such behavior. Confocal and fluorescence microscopes' results of the histological stained apoptotic cells confirmed positive and specific expressions of our designed probe. MRI monitoring results of apoptotic rat models after focal brain transient cerebral ischemia showed a remarkable time-dependent reduction of T2* weighted signal up to 4 h indicating that our newly designed hybrid probe has long blood circulation and could be used as a future contrasting agent. Moreover, the distribution of our probe was evaluated by subtracting the T2* signal images before and after injection with SR-FLICA-FMNPs and was significantly correlated with the histological findings by staining via terminal deoxynucleotidyl transferase-mediated uridine 5'-triphosphate-biotin nick end labeling. Moreover, clearance study confirmed that; our magneto-fluorescent hybrid probe could be cleared through liver Kupffer cells. Thus; the newly developed SR-FLICA-FMNPs could be considered as a future multifunctional probe for in vitro and in vivo apoptotic cells monitoring.

  128. Empathizing associates with mean diffusivity. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

    Scientific reports　9　(1)　8856-8856　2019/06/20

    DOI： 10.1038/s41598-019-45106-1 　

    More details Close

    Empathizing is defined as "the drive to identify another's mental states and to respond to these with an appropriate emotion" and systemizing is defined as "the drive to the drive to analyze and construct rule-based systems". While mean diffusivity (MD) has been robustly associated with several cognitive traits and disorders related with empathizing and systemizing, its direct correlation with empathizing and systemizing remains to be investigated. We undertook voxel-by-voxel investigations of regional MD to discover microstructural correlates of empathizing, systemizing, and the discrepancy between them (D score: systemizing - empathizing). Whole-brain analyses of covariance revealed that across both sexes, empathizing was positively correlated with MD of (a) an anatomical cluster that primarily spreads in the areas in and adjacent to the left dorsolateral prefrontal cortex, left anterior to the middle cingulate cortex, and left insula and (b) an anatomical cluster of the left postcentral gyrus and left rolandic operculum. The former overlaps with positive MD correlates of cooperativeness. The D score and systemizing did not show significant correlations. In conclusion, while increased MD has generally been associated with reduced neural tissues and possibly area function, higher empathizing and cooperativeness were commonly reflected by greater MD values in areas (a) that mainly overlap with areas that play a key role in emotional salience and empathy. In addition, higher empathizing was correlated with greater MD values in areas (b) that play a key role in the mirror neuron system.

  129. OLIG2遺伝子多型(rs1059004)と自己スキーマ及び抑うつ症状との関連

    小松 浩, 竹内 光, 菊地 淑恵, 小野 千晶, 兪 志前, 飯塚 邦夫, 角藤 芳久, 舩越 俊一, 大野 高志, 川島 隆太, 瀧 龍之, 富田 博秋

    精神神経学雑誌　(2019特別号)　S452-S452　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  130. Anxiety increases visual attention to hedonic foods: A preliminary eye-tracking study on the impact of the interplay between integral and incidental affect on foods. International-journal Peer-reviewed

    Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

    Appetite　137　218-225　2019/06

    DOI： 10.1016/j.appet.2019.02.009 　

    ISSN： 0195-6663

    More details Close

    Two types of affect influence consumers' attention: incidental affect unrelated to a particular perception or judgment and integral affect directly related to the particular options under consideration. Although integral and incidental affect likely coexist on a regular basis, the claim that both concurrently guide consumers' attention has thus far received little attention. To fill this gap, the present study investigated the effects of the interplay of integral and incidental affect on the visual processing of food. Food labels play an essential role in attracting consumer attention. Food labels include sources of integral affect (e.g., food type, pictures), and consumers often view food labels under the influence of incidental affect (e.g., an unrelated anxiety-inducing message or personal experience). According to the appraisal tendency framework, incidental experiences of anxiety can enhance affective processing of food due to the uncertainty associated with anxiety. In our study, participants were first subjected to manipulation of an incidental emotion (anxiety, anger, or neutral). Then, they passively viewed food labels, including pictures and nutrient labels, for hedonic and healthy foods. Subject's eye movements were tracked during this stage of the study. Our results showed that the induction of incidental anxiety, but not anger or neutral feelings, led to greater visual attention on hedonic foods only. These findings shed light on the interplay between incidental and integral affect in consumer information processing, demonstrating that the co-occurrence of incidental anxiety and integral hedonic feelings enhance visual attention to food.

  131. Association of copper levels in the hair with gray matter volume, mean diffusivity, and cognitive functions. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

    Brain structure & function　224　(3)　1203-1217　2019/04

    DOI： 10.1007/s00429-019-01830-y 　

    ISSN： 1863-2653

    More details Close

    Although copper plays a critical role in normal brain functions and development, it is known that excess copper causes toxicity. Here we investigated the associations of copper levels in the hair with regional gray matter volume (rGMV), mean diffusivity (MD), and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that high copper levels were associated mostly with low cognitive abilities (low scores on the intelligence test consisting of complex speed tasks, involving reasoning task, a complex arithmetic task, and a reading comprehension task) as well as lower reverse Stroop interference, high rGMV over widespread areas of the brain [mainly including the bilateral lateral and medial parietal cortices, medial temporal structures (amygdala, hippocampus, and parahippocampal gyrus), middle cingulate cortex, orbitofrontal cortex, insula, perisylvian areas, inferior temporal lobe, temporal pole, occipital lobes, and supplementary motor area], as well as high MD of the right substantia nigra and bilateral hippocampus, which are indicative of low density in brain tissues. These results suggest that copper levels are associated with mostly aberrant cognitive functions, greater rGMV in extensive areas, greater MD (which are indicative of low density in brain tissues) in subcortical structures in the healthy young adults, possibly reflecting copper's complex roles in neural mechanisms.

  132. Neural substrates of self- and external-preoccupation: A voxel-based morphometry study. International-journal Peer-reviewed

    Ikeda S, Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakaki K, Nozawa T, Yokota S, Magistro D, Kawashima R

    Brain and behavior　9　(6)　e01267　2019/04

    DOI： 10.1002/brb3.1267 　

    More details Close

    INTRODUCTION: Self- and external-preoccupation have been linked to psychopathological states. The neural substrates underlying self- and external-preoccupation remain unclear. In the present study, we aim to provide insight into the information-processing mechanisms associated with self- and external-preoccupation at the structural level. METHODS: To investigate the neural substrates of self- and external-preoccupation, we acquired high-resolution T1-weighted structural images and Preoccupation Scale scores from 1,122 young subjects. Associations between regional gray matter volume (rGMV) and Preoccupation Scale subscores for self- and external-preoccupation were estimated using voxel-based morphometry. RESULTS: Significant positive associations between self-preoccupation and rGMV were observed in widespread brain areas such as the bilateral precuneus and posterior cingulate gyri, structures known to be associated with self-triggered self-reference during rest. Significant negative associations between external-preoccupation and rGMV were observed only in the bilateral cerebellum, regions known to be associated with behavioral addiction, sustained attention, and reward system. CONCLUSION: Our results reveal distinct neural substrates for self- and external-preoccupation at the structural level.

  133. Light colors and comfortable warmth: Crossmodal correspondences between thermal sensations and color lightness influence consumer behavior Peer-reviewed

    Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

    Food Quality and Preference　72　45-55　2019/03

    DOI： 10.1016/j.foodqual.2018.09.004 　

    ISSN： 0950-3293

  134. Round Faces Are Associated with Sweet Foods: The Role of Crossmodal Correspondence in Social Perception. International-journal Peer-reviewed

    Motoki K, Saito T, Nouchi R, Kawashima R, Sugiura M

    Foods (Basel, Switzerland)　8　(3)　2019/03

    DOI： 10.3390/foods8030103 　

    More details Close

    In retail settings, social perception of other peoples' preferences is fundamental to successful interpersonal interactions (e.g., product recommendations, gift-giving). This type of perception must be made with little information, very often based solely on facial cues. Although people are capable of accurately predicting others' preferences from facial cues, we do not yet know how such inferences are made by crossmodal correspondence (arbitrary sensory associations) between facial cues and inferred attributes. The crossmodal correspondence literature implies the existence of sensory associations between shapes and tastes, and people consistently match roundness and angularity to sweet and sour foods, respectively. Given that peoples' faces have dimensions characterized by roundness and angularity, it may be plausible that people infer others' preferences by relying on the correspondence between facial roundness and taste. Based on a crossmodal correspondence framework, this study aimed to reveal the role of shape⁻taste correspondences in social perception. We investigated whether Japanese participants infer others' taste (sweet/sour) preferences based on facial shapes (roundness/angularity). The results showed that participants reliably inferred that round-faced (vs. angular-faced) individuals preferred sweet foods (Study 1). Round-faced individuals and sweet foods were well matched, and the matching mediated the inference of other person's preferences (Study 2). An association between facial roundness and inference of sweet taste preferences was observed in more natural faces, and perceived obesity mediated this association (Study 3). These findings advance the applicability of crossmodal correspondences in social perception, and imply the pervasiveness of prejudicial bias in the marketplace.

  135. Mean diffusivity related to collectivism among university students in Japan. International-journal Peer-reviewed

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

    Scientific reports　9　(1)　1338-1338　2019/02/04

    DOI： 10.1038/s41598-018-37995-5 　

    ISSN： 2045-2322

  136. Effect of the interaction between BDNF Val66Met polymorphism and daily physical activity on mean diffusivity. International-journal Peer-reviewed

    Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Brain imaging and behavior　2019/01/07

    DOI： 10.1007/s11682-018-0025-8 　

    ISSN： 1931-7557

    More details Close

    Numerous studies have reported that the Met allele of the brain-derived neurotrophic factor (BDNF) gene polymorphism reduces neural plasticity. A reduction in mean diffusivity (MD) in diffusion tensor imaging (DTI) characteristically reflects the neural plasticity that involves increased tissue components. In this study, we revealed that the number of Met-BDNF alleles was negatively associated with MD throughout the whole-brain gray and white matter areas of 743 subjects using DTI and whole-brain multiple regression analyses. Within the same sample, the region of interest analysis revealed that the number of Met-BDNF alleles significantly and positively correlated with the mean FA value in the body of the corpus callosum. In addition, we observed interaction effects between BDNF Val66Met polymorphism and daily physical activity levels on MD, but not FA, in significant clusters of the bilateral hemisphere (n = 577 subjects). Post-hoc multiple regression analyses revealed that after correcting for confounding variables, there was a significant negative correlation between the physical activity level and mean MD of the whole brain in the Val/Val group [standardized partial regression coefficient (β) = -0.196, P = 0.005, t = -2.825], but not in the Val/Met (β = 0.050, P = 0.412, t = 0.822) and Met/Met groups (β = 0.092, P = 0.382, t = 0.878). These results underscore the importance of the interaction between physical activity and the BDNF Val66Met polymorphism, which affects the plasticity of neural mechanisms.

  137. Newly Developed TV-Based Cognitive Training Games Improve Car Driving Skills, Cognitive Functions, and Mood in Healthy Older Adults: Evidence From a Randomized Controlled Trial. International-journal

    Rui Nouchi, Akiko Kobayashi, Haruka Nouchi, Ryuta Kawashima

    Frontiers in aging neuroscience　11　99-99　2019

    DOI： 10.3389/fnagi.2019.00099 　

    More details Close

    Background: Cognitive training in a laboratory improves car driving skills of older car drivers. However, it remains unclear whether other types of cognitive training at home have beneficial effects on driving skills. Using our developed cognitive training games that can be played on a television with a set-top box in a person's home, we investigated the effects of a 6-week cognitive training program on driving skills, which included on-road evaluation (primary outcome), and cognitive functions and emotional states (secondary outcome) in older people. Methods: In this double-blinded randomized control trial (RCT), 60 older licensed drivers were randomly assigned into one of the two groups: a cognitive training game for car driving (CTCD) group and an active control cognitive training game (ACT) group. Participants in the CTCD group played the CTCD (processing speed, dual attention, and speed prediction) for 20 min in five sessions per week for 6 weeks. Participants in the ACT group played the ACT (selecting the larger number; selecting a number from largest to smallest; play a game of rock, article, scissors) for 20 min in five sessions per week for 6 weeks. We measured driving skills, various cognitive functions, and emotional states before and after the 6-week intervention period. Results: Our main results showed that compared to the ACT group, the CTCD group demonstrated improved driving skills (adjusted p = 0.034). Moreover, the CTCD group demonstrated improved inhibition (stroop, adjusted p = 0.042: reverse Stroop, adjusted p = 0.043) and processing speed performance symbol search (SS), adjusted p = 0.049; digit symbol coding (adjusted p = 0.047), compared to the ACT group. The CTCD group scored higher on vigor-activity mood (adjusted p = 0.041) as measured using the Profile of Mood State. Discussion: This randomized controlled trial provides scientific evidence for the benefits of the 6-week CTCD program on driving skills and cognitive functions, such as processing speed, inhibition, and vigor-activity mood, in healthy older people. Our results suggest that cognitive training is useful to improve the driving skills of older adults. Trial registration: This trial was registered at The University Hospital Medical Information Network Clinical Trials Registry (UMIN 000029769). Registered 31 October 2017, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034010.

  138. Study Protocol: Does an Acute Intervention of High-Intensity Physical Exercise Followed by a Brain Training Video Game Have Immediate Effects on Brain Activity of Older People During Stroop Task in fMRI?-A Randomized Controlled Trial With Crossover Design. International-journal

    Robin Maximilian Himmelmeier, Rui Nouchi, Toshiki Saito, Dalila Burin, Jens Wiltfang, Ryuta Kawashima

    Frontiers in aging neuroscience　11　260-260　2019

    DOI： 10.3389/fnagi.2019.00260 　

    More details Close

    Background: Elderly people are affected by processes leading to decline in various aspects of daily living that impair their quality of life. Regarding neurological aspects, executive functions have been shown to be valuable for daily life and to slow decline during aging. Most intervention studies intended to improve cognitive functions during aging specifically address long-term destructive processes and countermeasures. However, to an increasing degree, studies also investigate the acute benefits that prove to be useful for daily life, such as physical exercise or video games in the form of exercise video gaming ("exergaming"). Because little is known about the change in cognitive ability following acute intervention of a combination of physical exercise and video gaming, especially for older people, this work is designed as an attempt to address this matter. Methods: This study is a randomized crossover controlled trial to test the response to an acute bout of high-intensity physical exercise followed by a short session with a brain training (Brain Age) video game in physically active and cognitively healthy older adults (60-70 years). The response is measured using Stroop task performance (cognitive task for executive function) and related brain activity assessed with functional magnetic resonance imaging (fMRI). The control conditions are low-intensity physical exercise and Tetris for video gaming. Discussion: This study is intended to provide insight into the alteration of executive function and its related brain activity from an acute intervention with a combination of physical exercise and video gaming in older people. The protocol might not be implementable in daily life to improve cognitive abilities. However, the results can support future studies that investigate cognition and the combination of physical exercise and video gaming. Moreover, it can provide real-life implications. Trial registration: This trial was registered in The University Hospital Medical Information Network Clinical Trials Registry (UMIN000033054). Registered 19 July 2018, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000037687.

  139. Emerging Cognitive Intervention Technologies to Meet the Needs of an Aging Population: A Systematic Review. International-journal

    Fady Alnajjar, Sumayya Khalid, Alistair A Vogan, Shingo Shimoda, Rui Nouchi, Ryuta Kawashima

    Frontiers in aging neuroscience　11　291-291　2019

    DOI： 10.3389/fnagi.2019.00291 　

    More details Close

    Background: Cognitive training helps to promote healthy aging and ease activities of daily living for older adults. Recently, experiments have been conducted using robots to perform this cognitive training. Methods: A review was conducted to examine the effects of computer-based cognitive interventions for older adults who were either healthy or experiencing mild cognitive impairment (MCI). A second study also examined the evolution of socially assistive robots (SAR) and their effectiveness at administering cognitive training for older adults. Results: Eighty-one studies published between 2009 and 2019 were identified for review, 56 of which focused on computerized cognitive training (CCT) while 25 examined the use of robotics. Twenty-four of the 56 CCT studies met the inclusion criteria. These were further classified into two groups: studies which used self-designed programs, and studies using commercially available ones. Of the 25 studies examining the use of robotics in cognitive intervention 7 met the inclusion criteria. Review shows that CCT improves cognitive function but that robots are more effective tools for improving cognition. Conclusion: It can be concluded that CCT is beneficial for older adults and though there are drawbacks to this approach they are overcome by the introduction of robots into the training process. Culture, language, and socio-economic considerations vis-a-vis robot design and training methodology should be included in future research.

  140. Two components in body image disturbance are associated with differential neural basis Peer-reviewed

    Hamamoto Yumi, Suzuki Shinsuke, Yamazaki Shohei, Motoki Kosuke, Oba Kentaro, Kawashima Ryuta, Sugiura Motoaki

    PSYCHOTHERAPY AND PSYCHOSOMATICS　88　53　2019

    ISSN： 0033-3190

  141. A Sweet Voice: The Influence of Cross-Modal Correspondences Between Taste and Vocal Pitch on Advertising Effectiveness. International-journal Peer-reviewed

    Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

    Multisensory research　32　(4-5)　401-427　2019/01

    DOI： 10.1163/22134808-20191365 　

    ISSN： 2213-4794

    More details Close

    We have seen a rapid growth of interest in cross-modal correspondences between sound and taste over recent years. People consistently associate higher-pitched sounds with sweet/sour foods, while lower-pitched sounds tend to be associated with bitter foods. The human voice is key in broadcast advertising, and the role of voice in communication generally is partly characterized by acoustic parameters of pitch. However, it remains unknown whether voice pitch and taste interactively influence consumer behavior. Since consumers prefer congruent sensory information, it is plausible that voice pitch and taste interactively influence consumers' responses to advertising stimuli. Based on the cross-modal correspondence phenomenon, this study aimed to elucidate the role played by voice pitch-taste correspondences in advertising effectiveness. Participants listened to voiceover advertisements (at a higher or lower pitch than the original narrator's voice) for three food products with distinct tastes (sweet, sour, and bitter) and rated their buying intention (an indicator of advertising effectiveness). The results show that the participants were likely to exhibit greater buying intention toward both sweet and sour food when they listened to higher-pitched (vs lower-pitched) voiceover advertisements. The influence of a higher pitch on sweet and sour food preferences was observed in only two of the three studies: studies 1 and 2 for sour food, and studies 2 and 3 for sweet food. These findings emphasize the role that voice pitch-taste correspondence plays in preference formation, and advance the applicability of cross-modal correspondences to business.

  142. Taking another’s perspective promotes right parieto-frontal activity that reflects open-minded thought Peer-reviewed

    Naoki Miura, Motoaki Sugiura, Takayuki Nozawa, Yuki Yamamoto, Yukako Sasaki, Yumi Hamamoto, Shohei Yamazaki, Kanan Hirano, Makoto Takahashi, Ryuta Kawashima

    Social Neuroscience　0　(0)　1-14　2019

    Publisher: Routledge

    DOI： 10.1080/17470919.2019.1710249 　

    More details Close

    PMID: 31888419

  143. rs1360780 of the FKBP5 gene modulates the association between maternal acceptance and regional gray matter volume in the thalamus in children and adolescents. Peer-reviewed

    Matsudaira I, Oba K, Takeuchi H, Sekiguchi A, Tomita H, Taki Y, Kawashima R

    PloS one　14　(8)　e0221768-e0221768　2019

    Publisher: Public Library of Science (PLoS)

    DOI： 10.1371/journal.pone.0221768 　

    eISSN： 1932-6203

  144. General intelligence is associated with working memory-related brain activity: new evidence from a large sample study. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

    Brain structure & function　223　(9)　4243-4258　2018/12

    DOI： 10.1007/s00429-018-1747-5 　

    ISSN： 1863-2653

    More details Close

    Psychometric intelligence is closely related to working memory capacity. Here we aim to determine the associations of neural activation patterns during the N-back working memory paradigm with psychometric intelligence and working memory performance. We solved the statistical problems of previous studies using (1) a large cohort of 1235 young adults and (2) robust voxel-by-voxel permutation-based statistics at the whole-brain level. Many of the significant correlations were weak, and our findings were not consistent with those of previous studies. We observed that many of the significant correlations involved brain areas in the periphery or boundaries between the task-positive network (TPN) and task-negative network (TNN), suggesting that the expansion of the TPN or TNN is associated with greater cognitive ability. Lower activity in TPN and less task-induced deactivation (TID) in TNN were associated with greater cognitive ability. These findings indicate that subjects with greater cognitive ability have a lower brain response to task demand, consistent with the notion that TID in TNN reflects cognitive demand but partly inconsistent with the prevailing neural efficiency theory. One exception was the pre-supplementary motor area, which plays a key role in cognitive control and sequential processing. In this area, intelligent subjects demonstrated greater activity related to working memory, suggesting that the pre-supplementary motor area plays a unique role in the execution of working memory tasks in intelligent subjects.

  145. Impact of frequency of internet use on development of brain structures and verbal intelligence: Longitudinal analyses. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

    Human brain mapping　39　(11)　4471-4479　2018/11

    DOI： 10.1002/hbm.24286 　

    ISSN： 1065-9471

    More details Close

    Excessive internet use is shown to be cross sectionally associated with lower cognitive functioning and reduced volume of several brain areas. However, the effects of daily internet use on the development of verbal intelligence and brain structures have not been investigated. Here, we cross sectionally examined the effects of the frequency of internet use on regional gray/white matter volume (rGMV/rWMV) and verbal intelligence as well as their longitudinal changes after 3.0 ± 0.3 (standard deviation) years in a large sample of children recruited from the general population (mean age, 11.2 ± 3.1 years; range, 5.7-18.4 years). Although there were no significant associations in cross sectional analyses, a higher frequency of internet use was found to be associated with decrease of verbal intelligence and smaller increase in rGMV and rWMV of widespread brain areas after a few years in longitudinal analyses. These areas involve areas related to language processing, attention and executive functions, emotion, and reward. In conclusion, frequent internet use is directly or indirectly associated with decrease of verbal intelligence and development to smaller gray matter volume at later stages.

  146. 回想による楽観性向上の個人差とその神経基盤の検討

    大場 健太郎, Barthel Marie, 阿部 光一, 平野 香南, 石橋 遼, 野内 類, 川島 隆太, 杉浦 元亮

    健康心理学会　31　(0)　2018/08/14

    Publisher: 一般社団法人 日本健康心理学会

  147. Approach or avoidance: Neural correlates of intelligence evaluation from faces International-journal Peer-reviewed

    Akimoto Yoritaka, Yamazaki Ryuichi, Sugiura Motoaki, Nouchi Rui, Terao Chiaki, Tsukiura Takashi, Kawashima Ryuta

    EUROPEAN JOURNAL OF NEUROSCIENCE　48　(1)　1680-1690　2018/07

    DOI： 10.1111/ejn.13974 　

    ISSN： 0953-816X

  148. Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain

    Mai Sakai, Hikaru Takeuchi, Zhiqian Yu, Yoshie Kikuchi, Chiaki Ono, Yuta Takahashi, Fumiaki Ito, Hiroo Matsuoka, Osamu Tanabe, Jun Yasuda, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

    Psychiatry and Clinical Neurosciences　72　(6)　409-422　2018/06

    DOI： 10.1111/pcn.12649 　

    ISSN： 1323-1316

    eISSN： 1440-1819

  149. Mean Diffusivity in the Dopaminergic System and Neural Differences Related to Dopaminergic System

    Hikaru Takeuchi, Ryuta Kawashima

    Current Neuropharmacology　16　(4)　460-474　2018/05/01

    Publisher: Bentham Science Publishers Ltd.

    DOI： 10.2174/1570159x15666171109124839 　

    ISSN： 1570-159X

  150. Shorter sleep duration and better sleep quality are associated with greater tissue density in the brain. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

    Scientific reports　8　(1)　5833-5833　2018/04/11

    DOI： 10.1038/s41598-018-24226-0 　

    More details Close

    Poor sleep quality is associated with unfavorable psychological measurements, whereas sleep duration has complex relationships with such measurements. The aim of this study was to identify the associations between microstructural properties of the brain and sleep duration/sleep quality in a young adult. The associations between mean diffusivity (MD), a measure of diffusion tensor imaging (DTI), and sleep duration/sleep quality were investigated in a study cohort of 1201 normal young adults. Positive correlations between sleep duration and MD of widespread areas of the brain, including the prefrontal cortex (PFC) and the dopaminergic systems, were identified. Negative correlations between sleep quality and MD of the widespread areas of the brain, including the PFC and the right hippocampus, were also detected. Lower MD has been previously associated with more neural tissues in the brain. Further, shorter sleep duration was associated with greater persistence and executive functioning (lower Stroop interference), whereas good sleep quality was associated with states and traits relevant to positive affects. These results suggest that bad sleep quality and longer sleep duration were associated with aberrant neurocognitive measurements in the brain in healthy young adults.

  151. REDUCED FUNCTIONAL CONNECTIVITY BETWEEN THE RIGHT VENTRAL ACC AND MFG PREDICTS PTSD SYMPTOMS AFTER A DISASTER Peer-reviewed

    Sekiguchi Atsushi, Kotozaki Yuka, Sugiura Motoaki, Nakagawa Seishu, Nouchi Rui, Miyauchi Carlos M, Takeuchi Hikaru, Taki Yasuyuki, Kawashima Ryuta

    PSYCHOSOMATIC MEDICINE　80　(3)　A72-A73　2018/04

    ISSN： 0033-3174

  152. Allergic tendencies are associated with larger gray matter volumes. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

    Scientific reports　8　(1)　3694-3694　2018/02/27

    DOI： 10.1038/s41598-018-21985-8 　

    More details Close

    Allergic tendencies are associated with important cognitive and physiological factors, such as intelligence and mathematical abilities. Allergies are widely prevalent, especially in modern life, and the reason for its association with important cognitive variables is an intriguing scientific question. However, despite the unique characteristics of cognitive correlates of allergy, the anatomical correlates of allergy remain unknown. The aim of this study was to identify the associations between regional gray matter volume (rGMV) and allergic tendencies in young adults. In a study cohort of 1,219 healthy, educated young adults, we identified a positive correlation between total allergic tendency and rGMV in large anatomical clusters that mainly encompassed the dorsal part of the cerebral neocortex, right anterior insula, and cerebellum. Furthermore,both mean rGMV of the entire part of these clusters and total allergenic tendency showed a significant positive correlation with spatial ability. These results suggest the link among allergic tendencies, larger rGMV, and the better spatial ability in healthy, educated young adults.

  153. Refractive error is associated with intracranial volume. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

    Scientific reports　8　(1)　175-175　2018/01/09

    DOI： 10.1038/s41598-017-18669-0 　

    More details Close

    Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.

  154. Structural studies of creativity measured by divergent thinking Peer-reviewed

    Hikaru Takeuchi, Ryuta Kawashima

    The Cambridge Handbook of the Neuroscience of Creativity　451-463　2018/01/01

    Publisher: Cambridge University Press

    DOI： 10.1017/9781316556238.026 　

  155. Intra-individual cognitive imbalance in ASD between perceptual reasoning and ambiguity-solving related to tool use: Comparison among children exhibiting ASD, AD/HD, and typical development Peer-reviewed

    Keisuke Wakusawa, Chieko Nara, Yuki Kubota, Yayoi Tomizawa, Yasuyuki Taki, Yuko Sassa, Satoru Kobayashi, Sato Suzuki-Muromoto, Mieko Hirose, Hiroyuki Yokoyama, Takahiro Nara, Shigeo Kure, Norio Mori, Noriyoshi Takei, Ryuta Kawashima

    Brain and Development　40　(1)　16-25　2018/01/01

    Publisher: Elsevier B.V.

    DOI： 10.1016/j.braindev.2017.07.002 　

    ISSN： 1872-7131 0387-7604

    eISSN： 1872-7131

  156. The Beneficial Effects of Cognitive Training With Simple Calculation and Reading Aloud (SCRA) in the Elderly Postoperative Population: A Pilot Randomized Controlled Trial. International-journal

    Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima

    Frontiers in aging neuroscience　10　68-68　2018

    DOI： 10.3389/fnagi.2018.00068 　

    More details Close

    Background: There has been little research conducted regarding cognitive treatments for the elderly postsurgical population. Patients aged ≥60 years have an increased risk of postoperative cognitive decline, a condition in which cognitive functions are negatively affected. This cognitive decline can lead to a decline in quality of life. In order to maintain a high quality of life, the elderly postsurgical population may benefit from treatment to maintain and/or improve their cognitive functions. This pilot study investigates the effect of simple calculation and reading aloud (SCRA) cognitive training in elderly Japanese postsurgical patients. Methods: Elderly patients undergoing non-cardiovascular thoracic surgery under general anesthesia were recruited (n = 12). Subjects were randomly divided into two groups-one that receives 12 weeks of SCRA intervention, and a waitlisted control group. Before and after the intervention, we measured cognitive function [Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), computerized Cogstate Brief Battery (CBB)] and emotional state [General Health Questionnaire-12 (GHQ-12), Geriatric Depression Scale (GDS), Quality of Life Scale-5 (QOL-5)]. Results: Group difference analyses using ANCOVA with permutation test showed that the intervention SCRA group had a significant improvement in FAB motor programming sub-score, GDS, and QOL-5 compared to the control group. Within-group analyses using Wilcoxon signed-rank test to compare baseline and follow-up showed that the SCRA intervention group total FAB scores, FAB motor programming sub-scores, and QOL-5 scores were significantly improved. Discussion: This pilot study showed that there are important implications for the beneficial effects of SCRA intervention on cognitive function and emotional state in the postoperative elderly population; however, further investigations are necessary to reach any conclusions. Trial registration: This study was registered with the University Hospital Medical Information Network (UMIN) Clinical Trial Registry (UMIN000019832).

  157. The paradox of warmth: Ambient warm temperature decreases preference for savory foods Peer-reviewed

    Motoki Kosuke, Saito Toshiki, Nouchi Rui, Kawashima Ryuta, Sugiura Motoaki

    Food Quality and Preference　69　1-9　2018

    DOI： 10.1016/j.foodqual.2018.04.006 　

    ISSN： 0950-3293

  158. Tastiness but not healthfulness captures automatic visual attention: Preliminary evidence from an eye-tracking study Peer-reviewed

    Motoki Kosuke, Saito Toshiki, Nouchi Rui, Sugiura Motoaki, Kawashima Ryuta, ual contribu

    Food Quality and Preference　64　148-153　2018

    DOI： 10.1016/j.foodqual.2017.09.014 　

    ISSN： 0950-3293

  159. The Effects of Family Socioeconomic Status on Psychological and Neural Mechanisms as Well as Their Sex Differences. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoishi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

    Frontiers in human neuroscience　12　543-543　2018

    DOI： 10.3389/fnhum.2018.00543 　

    More details Close

    Family socioeconomic status (SES) is an important factor that affects an individual's neural and cognitive development. The two novel aims of this study were to reveal (a) the effects of family SES on mean diffusivity (MD) using diffusion tensor imaging given the characteristic property of MD to reflect neural plasticity and development and (b) the sex differences in SES effects. In a study cohort of 1,216 normal young adults, we failed to find significant main effects of family SES on MD; however, previously observed main effects of family SES on regional gray matter volume and fractional anisotropy (FA) were partly replicated. We found a significant effect of the interaction between sex and family income on MD in the thalamus as well as significant effects of the interaction between sex and parents' educational qualification (year's of education) on MD and FA in the body of the corpus callosum as well as white matter areas between the anterior cingulate cortex and lateral prefrontal cortex. These results suggest the sex-specific associations of family SES with neural and/or cognitive mechanisms particularly in neural tissues in brain areas that play key roles in basic information processing and higher-order cognitive processes in a way females with greater family SES level show imaging outcome measures that have been associated with more neural tissues (such as greater FA and lower MD) and males showed opposite.

  160. Effects of Time-Compressed Speech Training on Multiple Functional and Structural Neural Mechanisms Involving the Left Superior Temporal Gyrus. International-journal Peer-reviewed

    Tsukasa Maruyama, Hikaru Takeuchi, Yasuyuki Taki, Kosuke Motoki, Hyeonjeong Jeong, Yuka Kotozaki, Seishu Nakagawa, Rui Nouchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Kohei Sakaki, Yukako Sasaki, Daniele Magistro, Ryuta Kawashima

    Neural plasticity　2018　6574178-6574178　2018

    DOI： 10.1155/2018/6574178 　

    ISSN： 2090-5904

    More details Close

    Time-compressed speech is an artificial form of rapidly presented speech. Training with time-compressed speech (TCSSL) in a second language leads to adaptation toward TCSSL. Here, we newly investigated the effects of 4 weeks of training with TCSSL on diverse cognitive functions and neural systems using the fractional amplitude of spontaneous low-frequency fluctuations (fALFF), resting-state functional connectivity (RSFC) with the left superior temporal gyrus (STG), fractional anisotropy (FA), and regional gray matter volume (rGMV) of young adults by magnetic resonance imaging. There were no significant differences in change of performance of measures of cognitive functions or second language skills after training with TCSSL compared with that of the active control group. However, compared with the active control group, training with TCSSL was associated with increased fALFF, RSFC, and FA and decreased rGMV involving areas in the left STG. These results lacked evidence of a far transfer effect of time-compressed speech training on a wide range of cognitive functions and second language skills in young adults. However, these results demonstrated effects of time-compressed speech training on gray and white matter structures as well as on resting-state intrinsic activity and connectivity involving the left STG, which plays a key role in listening comprehension.

  161. Benefits of "smart ageing" interventions using cognitive training, brain training games, exercise, and nutrition intake for aged memory functions in healthy elderly people Peer-reviewed

    Rui Nouchi, Ryuta Kawashima

    Memory in a Social Context: Brain, Mind, and Society　269-280　2017/12/15

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-56591-8_15 　

  162. Eyewear Equipped with a Triaxial Accelerometer Detects Age-Related Changes in Ambulatory Activity Invited Peer-reviewed

    Shigeyuki Ikeda, Susumu Ichinohe, Ryuta Kawashima

    DigitCult - Scientific Journal on Digital Cultures　2　(2)　1-8　2017/11

    DOI： 10.4399/97888255088951 　

  163. Neural correlates of ambient thermal sensation: An fMRI study Peer-reviewed

    Hajime Oi, Teruo Hashimoto, Takayuki Nozawa, Akitake Kanno, Natasha Kawata, Kanan Hirano, Yuki Yamamoto, Motoaki Sugiura, Ryuta Kawashima

    SCIENTIFIC REPORTS　7　2017/09

    DOI： 10.1038/s41598-017-11802-z 　

    ISSN： 2045-2322

  164. Lenticular nucleus correlates of general self-efficacy in young adults. International-journal Peer-reviewed

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

    Brain structure & function　222　(7)　3309-3318　2017/09

    DOI： 10.1007/s00429-017-1406-2 　

    ISSN： 1863-2653

    More details Close

    General self-efficacy (GSE) is an important factor in education, social participation, and medical treatment. However, the only study that has investigated the direct association between GSE and a neural correlate did not identify specific brain regions, rather only assessed brain structures, and included older adult subjects. GSE is related to motivation, physical activity, learning, the willingness to initiate behaviour and expend effort, and adjustment. Thus, it was hypothesized in the present study that the neural correlates of GSE might be related to changes in the basal ganglia, which is a region related to the abovementioned self-efficacy factors. This study aimed to identify the brain structures associated with GSE in healthy young adults (n = 1204, 691 males and 513 females, age 20.7 ± 1.8 years) using regional grey matter density and volume (rGMD and rGMV), fractional anisotropy (FA) and mean diffusivity (MD) analyses of magnetic resonance imaging (MRI) data. The findings showed that scores on the GSE Scale (GSES) were associated with a lower MD value in regions from the right putamen to the globus pallidum; however, there were no significant association between GSES scores and regional brain structures using the other analyses (rGMD, rGMV, and FA). Thus, the present findings indicated that the lenticular nucleus is a neural correlate of GSE.

  165. Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

    Scientific reports　7　(1)　10014-10014　2017/08/30

    DOI： 10.1038/s41598-017-10104-8 　

    More details Close

    Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on the available evidence, we hypothesized that diverse CCAs are all positively but only weakly associated with rGMV in widespread brain areas. To test this hypothesis, we used the data from a large sample of healthy young adults [776 males and 560 females; mean age: 20.8 years, standard deviation (SD) = 0.8] and investigated associations between rGMV and scores on multiple CCA tasks (including non-verbal reasoning, verbal working memory, Stroop interference, and complex processing speed tasks involving spatial cognition and reasoning). Better performance scores on all tasks except non-verbal reasoning were associated with greater rGMV across widespread brain areas. The effect sizes of individual associations were generally low, consistent with our previous studies. The lack of strong correlations between rGMV and specific CCAs, combined with stringent corrections for multiple comparisons, may lead to different and diverse findings in the field.

  166. Gaze Bias in Preference Judgments by Younger and Older Adults International-journal Peer-reviewed

    Saito Toshiki, Nouchi Rui, Kinjo Hikari, Kawashima Ryuta

    Frontiers in Aging Neuroscience　9　285-285　2017/08

    DOI： 10.3389/fnagi.2017.00285 　

    ISSN： 1663-4365

    More details Close

    Individuals' gaze behavior reflects the choice they will ultimately make. For example, people confronting a choice among multiple stimuli tend to look longer at stimuli that are subsequently chosen than at other stimuli. This tendency, called the gaze bias effect, is a key aspect of visual decision-making. Nevertheless, no study has examined the generality of the gaze bias effect in older adults. Here, we used a two-alternative forced-choice task (2AFC) to compare the gaze behavior reflective of different stages of decision processes demonstrated by younger and older adults. Participants who had viewed two faces were instructed to choose the one that they liked/disliked or the one that they judged to be more/less similar to their own face. Their eye movements were tracked while they chose. The results show that the gaze bias effect occurred during the remaining time in both age groups irrespective of the decision type. However, no gaze bias effect was observed for the preference judgment during the first dwell time. Our study demonstrated that the gaze bias during the remaining time occurred regardless of decision-making task and age. Further study using diverse participants, such as clinic patients or infants, may help to generalize the gaze bias effect and to elucidate the mechanisms underlying the gaze bias.

  167. Noninvasive stroke volume variation using electrical velocimetry for predicting fluid responsiveness in dogs undergoing cardiac surgery Peer-reviewed

    Kazumasu Sasaki, Tatsushi Mutoh, Tomoko Mutoh, Yasuyuki Taki, Ryuta Kawashima

    Veterinary Anaesthesia and Analgesia　44　(4)　719-726　2017/07/01

    Publisher: Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia

    DOI： 10.1016/j.vaa.2016.11.001 　

    ISSN： 1467-2995 1467-2987

  168. Neural Mechanisms Underlying the Reward-Related Enhancement of Motivation When Remembering Episodic Memories With High Difficulty Peer-reviewed

    Yayoi Shigemune, Takashi Tsukiura, Rui Nouchi, Toshimune Kambara, Ryuta Kawashima

    HUMAN BRAIN MAPPING　38　(7)　3428-3443　2017/07

    DOI： 10.1002/hbm.23599 　

    ISSN： 1065-9471

    eISSN： 1097-0193

  169. The VEGF gene polymorphism impacts brain volume and arterial blood volume. International-journal Peer-reviewed

    Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Human brain mapping　38　(7)　3516-3526　2017/07

    DOI： 10.1002/hbm.23606 　

    ISSN： 1065-9471

    More details Close

    Vascular endothelial growth factor (VEGF) plays a critical role in the angiogenesis and proliferation of various types of cells such as neurons, astroglia, and endothelial cells in the brain. A common polymorphism in the VEGF gene (-2578 C/A) is associated with circulating VEGF levels, cancers and Alzheimer's disease. Nonetheless, the effects of this polymorphism on normal human brain volume, arterial blood volume, and blood supply remain unclear. In this study, the effects of this polymorphism on the total gray matter volume (TGMV) and total white matter volume (TWMV) using T1-weighted structural images and the total arterial blood volume (TABV) and mean cerebral blood flow (mCBF) during rest using arterial spin labeling (ASL) in 765 young adult humans were investigated. Voxel-by-voxel whole-brain analyses of these measures were also performed. Multiple regression analyses with age and sex as covariates revealed that the VEGF genotype (number of C alleles) was significantly and positively correlated with TGMV, TWMV, and TABV as well as with regional gray and white matter volumes in widespread areas and regional arterial blood volume in some areas with high arterial blood volume. However, these regional associations were not seen when the corresponding global signal was included as a covariate in the multiple regression analyses, indicating that we failed to obtain evidence of region-specific associations between these brain measures and the genotype. The results suggest that the VEGF-2578C allele, is associated with changes in the vascular system that lead to increased blood volume and larger brain volume. Hum Brain Mapp 38:3516-3526, 2017. © 2017 Wiley Periodicals, Inc.

  170. Neural correlates of bilingual language control during interlingual homograph processing in a logogram writing system Peer-reviewed

    Hsieh MH, Jeong H, Kawata KH, Sasaki Y, Lee HC, Yokoyama S, Sugiura M, Kawashima R, qual contribution

    Brain and Language　174　72-85　2017/07

    DOI： 10.1016/j.bandl.2017.06.006 　

    ISSN： 0093-934X

    More details Close

    Bilingual studies using alphabetic languages have shown parallel activation of two languages during word recognition. However, little is known about the brain mechanisms of language control during word comprehension with a logogram writing system. We manipulated the types of words (interlingual homographs (IH), cognates, and language-specific words) and the types of participants (Chinese (L1)-Japanese (L2) bilinguals vs. Japanese monolinguals). Greater activation was found in the bilateral inferior frontal gyri, supplementary motor area, caudate nucleus and left fusiform gyrus, when the bilinguals processed IH, as compared to cognates. These areas were also commonly activated when the bilinguals processed L2 control words during an L1 lexical decision task. The areas function as the task/decision system that plays a role in cognitive control for resolving response conflict. Furthermore, the anterior cingulate cortex, left thalamus, and left middle temporal gyrus were activated during IH processing, suggesting resolution of the semantic conflict at the stimulus level (i.e., one logographic word having different meanings in the two languages).

  171. グリア線維酸性蛋白質遺伝子多型の脳構造への影響の検討 精神疾患感受性メカニズムの理解に向けて

    高橋 雄太, 伊藤 文晃, 竹内 光, 坂井 舞, 兪 志前, 松岡 洋夫, 瀧 靖之, 川島 隆太, 富田 博秋

    精神神経学雑誌　(2017特別号)　S622-S622　2017/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  172. EXPERIMENTAL STUDY ON TEAM COORDINATION OF NPP PLANT OPERATORS BASED ON THE SIMULTANEOUS NIRS MEASUREMENTS Peer-reviewed

    Makoto Takahashi, Fumiyasu Shirai, Ryuta Kawashima, Kazukiyo Ueda

    Transactions of the American Nuclear Society　116　1226-1233　2017/06

  173. Evaluating age-related change in lip somatosensation using somatosensory evoked magnetic fields Peer-reviewed

    Hiroki Hihara, Hiroyasu Kanetaka, Akitake Kanno, Satoko Koeda, Nobukazu Nakasato, Ryuta Kawashima, Keiichi Sasaki

    PLOS ONE　12　(6)　e0179323　2017/06

    DOI： 10.1371/journal.pone.0179323 　

    ISSN： 1932-6203

  174. Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

    NeuroImage　152　258-269　2017/05/15

    DOI： 10.1016/j.neuroimage.2017.02.079 　

    ISSN： 1053-8119

    More details Close

    Brain connectivity is traditionally thought to be important for creativity. Here we investigated the associations of creativity measured by divergent thinking (CMDT) with resting-state functional magnetic imaging (fMRI) measures and their sex differences. We examined these relationships in the brains of 1277 healthy young adults. Whole-brain analyses revealed a significant interaction between verbal CMDT and sex on (a) regional homogeneity within an area from the left anterior temporal lobe (b) on the resting state functional connectivity (RSFC) between the mPFC and the left inferior frontal gyrus and (c) on fractional amplitude of low frequency fluctuations (fALFF) in several distinct areas, including the precuneus and middle cingulate gyrus, left middle temporal gyrus, right middle frontal gyrus, and cerebellum. These interactions were mediated by positive correlations in females and negative correlations in males. These findings suggest that greater CMDT in females is reflected by (a) regional coherence (regional homogeneity) of brain areas responsible for representing and combining concepts as well as (b) the efficient functional connection (RSFC) between the key areas for the default state of cognitive activity and speech production, and (c) greater spontaneous neural activity (fALFF) during the resting of brain areas involved in frontal lobe functions, default cognitive activities, and language functions. Furthermore, these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females.

  175. Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

    Scientific reports　7　(1)　1470-1470　2017/05/03

    DOI： 10.1038/s41598-017-01460-6 　

    More details Close

    Working memory training (WMT) induces changes in cognitive function and various neurological systems. Here, we investigated changes in recently developed resting state functional magnetic resonance imaging measures of global information processing [degree of the cortical hub, which may have a central role in information integration in the brain, degree centrality (DC)], the magnitude of intrinsic brain activity [fractional amplitude of low frequency fluctuation (fALFF)], and local connectivity (regional homogeneity) in young adults, who either underwent WMT or received no intervention for 4 weeks. Compared with no intervention, WMT increased DC in the anatomical cluster, including anterior cingulate cortex (ACC), to the medial prefrontal cortex (mPFC). Furthermore, WMT increased fALFF in the anatomical cluster including the right dorsolateral prefrontal cortex (DLPFC), frontopolar area and mPFC. WMT increased regional homogeneity in the anatomical cluster that spread from the precuneus to posterior cingulate cortex and posterior parietal cortex. These results suggest WMT-induced plasticity in spontaneous brain activity and global and local information processing in areas of the major networks of the brain during rest.

  176. Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models Peer-reviewed

    Shogo Ogita, Toshiki Endo, Shinichiro Sugiyama, Ryuta Saito, Tomoo Inoue, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Yukihiko Sonoda, Teiji Tominaga

    ACTA NEUROCHIRURGICA　159　(5)　939-946　2017/05

    DOI： 10.1007/s00701-017-3123-2 　

    ISSN： 0001-6268

    eISSN： 0942-0940

  177. Structural brain development in healthy children and adolescents Peer-reviewed

    Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki

    Brain and Nerve　69　(5)　539-545　2017/05/01

    Publisher: Igaku-Shoin Ltd

    ISSN： 1881-6096

  178. 健常小児の脳の形態的発達

    松平 泉, 瀧靖之, 川島隆太

    BRAIN and NERVE　69　(5)　539-545　2017/05

  179. Sexual differentiation of the adolescent rat brain: A longitudinal voxel-based morphometry study. International-journal Peer-reviewed

    Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima

    Neuroscience letters　642　168-173　2017/03/06

    DOI： 10.1016/j.neulet.2016.12.023 　

    More details Close

    The sexual differentiation of the rat brain during the adolescent period has been well documented in post-mortem histological studies. However, to further understand the morphological changes occurring in the entire brain, a noninvasive neuroimaging method allowing an unbiased, comprehensive, and longitudinal investigation of brain morphology should be used. In this study, we investigated the sexual differentiation of the rat brain during the adolescent period using longitudinal voxel-based morphometry (VBM) analysis. Male and female Wistar rats (n=12 of each) were scanned in a 7.0-T MRI scanner at five time points from 6 to 10 weeks of age. The T2-weighted MRI images were segmented using the rat brain tissue priors that have been published by our laboratory. At the global level, the results of the VBM analysis showed greater increases in total gray matter volume in the males during the adolescent period, although we did not find significant differences in total white matter volume. At the voxel level, we found significant increases in the regional gray matter volume of the occipital cortex, amygdala, hippocampal formation, and cerebellum. At the regional level, only the occipital cortex in the females exhibited decreases during the adolescent period. These results were, at least in part, consistent with those of previous longitudinal VBM studies in humans, thus providing translational evidence of the sexual differentiation of the developing brain between rodents and humans.

  180. INSTRUCTIONAL SCAFFOLDING IN A UNIVERSITY EFL COURSE IN JAPAN: TOWARD THE INVESTIGATION OF STUDENTS’ FLOW IN A CLASSROOM

    Mutsumi Kondo, Takayuki Nozawa, Hyeonjeong Jeong, Shigeyuki Ikeda, Kohei Sakaki, Ryuta Kawashima, Reiko Yamamoto, Yasushige Ishikawa

    INTED2017 Proceedings　2017/03

    Publisher: IATED

    DOI： 10.21125/inted.2017.1742 　

  181. Social Interaction Affects Neural Outcomes of Sign Language Learning As a Foreign Language in Adults Peer-reviewed

    Noriaki Yusa, Jungho Kim, Masatoshi Koizumi, Motoaki Sugiura, Ryuta Kawashima

    FRONTIERS IN HUMAN NEUROSCIENCE　11　2017/03

    DOI： 10.3389/fnhum.2017.00115 　

    ISSN： 1662-5161

  182. Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Brain structure & function　222　(2)　1027-1037　2017/03

    DOI： 10.1007/s00429-016-1262-5 　

    ISSN： 1863-2653

    More details Close

    Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions. We detected associations between the higher Vigor subscale of POMS and lower MD in the right globus pallidum, right putamen to right posterior insula, right caudate body, and right thalamus, and these associations were highly specific to the Vigor subscale. Similarly, the association of the motivational state with creativity measured by divergent thinking (CMDT) was rather specific and prominent compared with that of the other mood states and cognitive functions. In conclusion, when affective states are finely divided, only the motivational state is associated with MD in the areas related to the dopaminergic system, and psychological mechanisms that had been associated with dopaminergic system (CMDT). These results suggest that these mechanisms specifically contribute to the motivational state and not to the other states, such as depression and anxiety.

  183. 呈示された音の高さに合わせた発声中における皮質活動 時間-周波数分析を用いた脳磁図の研究(Cortical activity during vocalization tuned to the pitch of the presented sound: magnetoencephalographic study using time-frequency analysis)

    Nomura Yuri, Kawase Tetsuaki, Kanno Akitake, Nakasato Nobukazu, Kawashima Ryuta, Katori Yukio

    日本生体磁気学会誌　30　(1)　67-67　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  184. 歯周靱帯に対する体性感覚刺激により惹起される磁界(Somatosensory evoked magnetic fields for the periodontal ligaments)

    Hihara Hiroki, Kanetaka Hiroyasu, Kanno Akitake, Nakasato Nobukazu, Kawashima Ryuta, Sasaki Keiichi

    日本生体磁気学会誌　30　(1)　76-76　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  185. 脳皮質における歯周靱帯刺激に対する体性感覚の応答(Somatosensory evoked responses in the cerebral cortex to periodontal ligament stimulation)

    Shimada Eriya, Kanetaka Hiroyasu, Kanno Akitake, Kawashima Ryuta, Nakasato Nobukazu, Igarashi Kaoru

    日本生体磁気学会誌　30　(1)　77-77　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  186. 脳磁計で特異的に検出された前臨床状態のてんかんの1症例(A case of subclinical seizures uniquely detected by magnetoencephalography)

    Ishida Makoto, Kanno Akitake, Kakisaka Yosuke, Iwasaki Masaki, Jin Kazutaka, Kitazawa Yu, Kawashima Ryuta, Nakasato Nobukazu

    日本生体磁気学会誌　30　(1)　79-79　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  187. Electrical velocimetry for noninvasive cardiac output and stroke volume variation measurements in dogs undergoing cardiovascular surgery Peer-reviewed

    Kazumasu Sasaki, Tatsushi Mutoh, Tomoko Mutoh, Ryuta Kawashima, Hirokazu Tsubonez

    VETERINARY ANAESTHESIA AND ANALGESIA　44　(1)　7-16　2017/01

    DOI： 10.1111/vaa.12380 　

    ISSN： 1467-2987

    eISSN： 1467-2995

  188. Indication of Cognitive Change and Associated Risk Factor after Thoracic Surgery in the Elderly: A Pilot Study. International-journal

    Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima

    Frontiers in aging neuroscience　9　396-396　2017

    DOI： 10.3389/fnagi.2017.00396 　

    More details Close

    Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery is aging. Methods: Cognitive function was measured for all subjects (n = 12) before and after surgery using three different cognitive tests: Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), and a computerized Cogstate Brief Battery (CBB). Changes in these measures indicate changes in cognitive function. In addition, the 12-item General Health Questionnaire (GHQ-12), the Geriatric Depression Scale (GDS), and the 5-item Quality of Life questionnaire (QOL-5) were administered at each time point to measure mental and emotional state. Changes in outcome measures were analyzed via Wilcoxon signed-rank test. Exploratory correlation analysis was conducted using Spearman's rho. Results: Data show a decline in detection (DET; p = 0.045) and identification (IDN; p = 0.038). Spearman's correlation coefficient show a significant correlation between postoperative DET scores and postoperative IDN scores (ρ = 0.78, p = 0.005), a significant correlation between change in IDN and baseline GHQ-12 scores (ρ = -0.595, p = 0.027), and a significant correlation between change in one-back (OBK) scores and duration of anesthesia (ρ = -0.72, p = 0.012). Discussion: This was the first report to examine cognitive decline after major thoracic surgery in Japanese patients. Previous studies have evidenced that POCD is a common phenomenon after surgery, and that age is a major risk factor. The CCB measured significant change in two cognitive domains: attention and psycomotor function. This study clarified that decline in cognition is detectable in certain measures after thoracic surgery in the elderly Japanese patient population. Additionally, longer anesthetic exposure may negatively impact attention and working memory, and preoperative mental wellbeing is a possible predictor of POCD. These preliminary results have important implications and support the need for future studies.

  189. Steady beat sound facilitates both coordinated group walking and inter-subject neural synchrony Peer-reviewed

    Shigeyuki Ikeda, Takayuki Nozawa, Ryoichi Yokoyama, Atsuko Miyazaki, Yukako Sasaki, Kohei Sakaki, Ryuta Kawashima

    Frontiers in Human Neuroscience　11　147　2017

    Publisher: Frontiers Media SA

    DOI： 10.3389/fnhum.2017.00147 　

    eISSN： 1662-5161

  190. VBM and cognitive functions (review) Invited

    Takeuchi H, Kawashima R

    Brain and Nerve　in press　2017

  191. Neural bases of the adaptive mechanisms associated with reciprocal partner choice Peer-reviewed

    Ryoichi Yokoyama, Motoaki Sugiura, Yuki Yamamoto, Keyvan Kashkouli Nejad, Ryuta Kawashima

    NEUROIMAGE　145　74-81　2017/01

    DOI： 10.1016/j.neuroimage.2016.09.052 　

    ISSN： 1053-8119

    eISSN： 1095-9572

  192. Effects of Visual Speech on Early Auditory Evoked Fields - From the Viewpoint of Individual Variance Peer-reviewed

    Izumi Yahata, Tetsuaki Kawase, Akitake Kanno, Hiroshi Hidaka, Shuichi Sakamoto, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

    PLOS ONE　12　(1)　e0170166　2017/01

    DOI： 10.1371/journal.pone.0170166 　

    ISSN： 1932-6203

  193. The anterior midcingulate cortex as a neural node underlying hostility in young adults. International-journal Peer-reviewed

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Brain structure & function　222　(1)　61-70　2017/01

    DOI： 10.1007/s00429-016-1200-6 　

    ISSN： 1863-2661 1863-2653

    More details Close

    Anger typically manifests for only a short period of time, whereas hostility is present for a longer duration. However, both of these emotions are associated with an increased likelihood of psychological problems. The nodes within the neural networks that underlie hostility remain unclear. We presumed that specific nodes might include the anterior midcingulate cortex (aMCC), which seems to be essential for the cognitive aspects of hostility. Thus, the present study first evaluated the associations between regional gray matter density (rGMD) and hostility in 777 healthy young students (433 men and 344 women; 20.7 ± 1.8 years of age) using magnetic resonance imaging and the hostile behaviors subscale (HBS) of the Coronary-prone Type Scale (CTS) for Japanese populations. The HBS scores were positively correlated with rGMD in the aMCC and in widespread frontal regions from the dorsomedial/dorsolateral prefrontal cortices to the lateral premotor cortex at the whole-brain level. No significant correlation was observed between rGMD and the conjunction of HBS and Trait Anger/Anger-Out scores. Furthermore, no significant interaction effects of sex and HBS scores on rGMD were revealed, although the HBS scores of males were significantly higher than those of females. The present findings indicate that the neural correlates of hostility appear to be more distinct in rGMD than those of anger due to differences and duration.

  194. Creative females have larger white matter structures: Evidence from a large sample study. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

    Human brain mapping　38　(1)　414-430　2017/01

    DOI： 10.1002/hbm.23369 　

    ISSN： 1065-9471

    More details Close

    The importance of brain connectivity for creativity has been theoretically suggested and empirically demonstrated. Studies have shown sex differences in creativity measured by divergent thinking (CMDT) as well as sex differences in the structural correlates of CMDT. However, the relationships between regional white matter volume (rWMV) and CMDT and associated sex differences have never been directly investigated. In addition, structural studies have shown poor replicability and inaccuracy of multiple comparisons over the whole brain. To address these issues, we used the data from a large sample of healthy young adults (776 males and 560 females; mean age: 20.8 years, SD = 0.8). We investigated the relationship between CMDT and WMV using the newest version of voxel-based morphometry (VBM). We corrected for multiple comparisons over whole brain using the permutation-based method, which is known to be quite accurate and robust. Significant positive correlations between rWMV and CMDT scores were observed in widespread areas below the neocortex specifically in females. These associations with CMDT were not observed in analyses of fractional anisotropy using diffusion tensor imaging. Using rigorous methods, our findings further supported the importance of brain connectivity for creativity as well as its female-specific association. Hum Brain Mapp 38:414-430, 2017. © 2016 Wiley Periodicals, Inc.

  195. A Comprehensive Analysis of the Correlations between Resting-State Oscillations in Multiple-Frequency Bands and Big Five Traits. International-journal Peer-reviewed

    Shigeyuki Ikeda, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

    Frontiers in human neuroscience　11　321-321　2017

    DOI： 10.3389/fnhum.2017.00321 　

    More details Close

    Recently, the association between human personality traits and resting-state brain activity has gained interest in neuroimaging studies. However, it remains unclear if Big Five personality traits are represented in frequency bands (~0.25 Hz) of resting-state functional magnetic resonance imaging (fMRI) activity. Based on earlier neurophysiological studies, we investigated the correlation between the five personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI), and the fractional amplitude of low-frequency fluctuation (fALFF) at four distinct frequency bands (slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.073 Hz), slow-3 (0.073-0.198 Hz) and slow-2 (0.198-0.25 Hz)). We enrolled 835 young subjects and calculated the correlations of resting-state fMRI signals using a multiple regression analysis. We found a significant and consistent correlation between fALFF and the personality trait of extraversion at all frequency bands. Furthermore, significant correlations were detected in distinct brain regions for each frequency band. This finding supports the frequency-specific spatial representations of personality traits as previously suggested. In conclusion, our data highlight an association between human personality traits and fALFF at four distinct frequency bands.

  196. Impact of Audio-Visual Asynchrony on Lip-Reading Effects -Neuromagnetic and Psychophysical Study- Peer-reviewed

    Tetsuaki Kawase, Izumi Yahata, Akitake Kanno, Shuichi Sakamoto, Yoshitaka Takanashi, Shiho Takata, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

    PLOS ONE　11　(12)　e0168740　2016/12

    DOI： 10.1371/journal.pone.0168740 　

    ISSN： 1932-6203

  197. Impact of videogame play on the brain’s microstructural properties: Cross-sectional and longitudinal analyses Peer-reviewed

    Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R

    Molecular Psychiatry　21　(12)　1781-1789　2016/12

    DOI： 10.1038/mp.2015.193 　

  198. Postoperative hormonal therapy prevents recovery of neurological damage after surgery in patients with breast cancer. International-journal Peer-reviewed

    Atsushi Sekiguchi, Chiho Sato, Izumi Matsudaira, Yuka Kotozaki, Rui Nouchi, Hikaru Takeuchi, Masaaki Kawai, Hiroshi Tada, Takanori Ishida, Yasuyuki Taki, Noriaki Ohuchi, Ryuta Kawashima

    Scientific reports　6　34671-34671　2016/10/06

    DOI： 10.1038/srep34671 　

    ISSN： 2045-2322

    More details Close

    Cancer survivors are exposed to several risk factors for cognitive dysfunction, such as general anesthesia, surgical trauma, and adjuvant therapies. In our recent study we showed that thalamic volume reduction and attentional dysfunction occurred shortly after surgery. Here, we examined the 6-month prognosis of the 20 patients with breast cancer who underwent surgery. Seven patients did not receive any adjuvant therapy after the surgery and 13 patients received a hormonal therapy after the surgery. We assessed their attentional functions, and thalamic volumes shortly after and 6 months after surgery. We found a significant group x time interaction in the attentional functions (p = 0.033) and the right thalamus (p <  0.05, small volume correction), suggesting the thalamic volume reduction and attentional dysfunction recovered in patients without adjuvant therapy. Our findings provide a better understanding of the potential role of hormonal therapy in relation to the cognitive dysfunction of cancer survivors.

  199. Convection-enhanced delivery of SN-38-loaded polymeric micelles (NK012) enables consistent distribution of SN-38 and is effective against rodent intracranial brain tumor models Peer-reviewed

    Rong Zhang, Ryuta Saito, Yui Mano, Akira Sumiyoshi, Masayuki Kanamori, Yukihiko Sonoda, Ryuta Kawashima, Teiji Tominaga

    DRUG DELIVERY　23　(8)　2780-2786　2016/10

    DOI： 10.3109/10717544.2015.1081994 　

    ISSN： 1071-7544

    eISSN： 1521-0464

  200. Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster. International-journal Peer-reviewed

    Seishu Nakagawa, Motoaki Sugiura, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Sugiko Hanawa, Tsuyoshi Araki, Hikaru Takeuchi, Atsushi Sakuma, Yasuyuki Taki, Ryuta Kawashima

    Scientific reports　6　34364-34364　2016/09/27

    DOI： 10.1038/srep34364 　

    ISSN： 2045-2322

    More details Close

    The relating to others factor of post-traumatic growth (PTG), which involves mutual help and a strong sense of connection with humanity, is important for young people who are coping with stress. The prefrontal cortex (PFC), especially the dorsolateral PFC (DLPFC), may play an important role in post-traumatic stress disorder (PTSD) with regard to coping and resilience. We hypothesized that the neural correlates of PTG may be responsible for resilience to the correlates of PTSD. Our study tested this hypothesis by examining whether measures of PTG, particularly the measures of relating to others after a disaster, were associated with increased regional grey matter volume (rGMV) in the PFC by assessing individuals who had experienced the East Japan Great Earthquake. We calculated the delta-rGMV by subtracting the rGMV obtained 3 months before the disaster from the rGMV obtained after this disaster using voxel-based morphometry. The magnetic resonance imaging data obtained from 26 subjects (M/F: 21/5; age: 21.2 ± 1.6 yrs.) showed that the total scores on a PTG inventory and the subscore for relating to others at the post-assessment were positively and significantly associated with the delta-rGMV in the right DLPFC. The DLPFC seems to be the main neural correlate of PTG.

  201. Neuroanatomical bases of effortful control: evidence from a large sample of young healthy adults using voxel-based morphometry. International-journal Peer-reviewed

    Rui Nouchi, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Yuko Sassa, Ryuta Kawashima

    Scientific reports　6　31231-31231　2016/08/09

    DOI： 10.1038/srep31231 　

    ISSN： 2045-2322

    More details Close

    Effortful control (EC) is a base of individuality in cognition and psychological adjustment. EC is defined as a capacity to control responses and behaviors. We investigated associations between individual differences of EC and regional gray and white matter volume (rGMV/rGMV) in 374 men and 306 women (age, 20.61 ± 1.82 years) using Japanese version of Effortful control scale (J-ECS). J-ECS consists of three subscales such as inhibitory control (IC), activation control (ACTC), and attentional control (ATC). Results showed that (a) IC was associated with larger rGMV in the dorsal part of anterior cingulate cortex (dACC), the supplementary motor area (SMA) and the pre SMA and larger rWMV in the dACC, (b) ACTC was correlated with smaller rGMV in the insula and the putamen, and (c) ATC was associated with larger rWMV in the inferior frontal gyrus, orbital frontal gyrus, ACC, and insula. Our study revealed key neuroanatomical correlations between EC and rGMV and rWMV.

  202. The beneficial effects of cognitive training with simple calculation and reading aloud in an elderly postsurgical population: study protocol for a randomized controlled trial. International-journal

    Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima

    Trials　17　334-334　2016/07/22

    DOI： 10.1186/s13063-016-1476-0 　

    More details Close

    BACKGROUND: This project proposes a pilot study to investigate the positive healing effects of cognitive training with simple arithmetic and reading aloud on elderly postsurgical patients. Elderly patients undergoing surgery have an increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery has aged. Little effort has been expended, however, to find treatments for POCD. Learning therapy, which consists of a combination of reading aloud and solving simple arithmetic problems, was developed in Japan as a treatment for Alzheimer's Disease to improve cognitive functions. Because patients with Alzheimer's Disease experience similar issues as those with POCD in learning, memory, and processing speed, a cognitive intervention based on the learning-therapy treatments used for Alzheimer's Disease could show advantageous outcomes for those at risk of POCD. METHODS/DESIGN: Cognitive function will be measured before and after surgery using three different tests (Mini-Mental Status Exam, Frontal Assessment Battery, and Cogstate computerized tests). Subjects will be randomly divided into two groups-one that receives a Simple Calculation and Reading Aloud intervention (SCRA) and a waitlisted control group that does not receive SCRA. To measure cognition before and after the intervention, the previously mentioned three tests will be used. The obtained data will be analyzed using statistical tests such as ANCOVA to indicate whether the cognitive intervention group has made improvements in their cognitive functions. In addition, questionnaires will also be administered to collect data on mental and emotional statuses. DISCUSSION: This report will be the first pilot study to investigate the beneficial effects of SCRA on elderly surgical patients. Previous studies have shown sufficient evidence on the effectiveness of learning therapy in healthy elderly people and in those with Dementia. Therefore, this study will clarify whether SCRA can improve cognitive function in the more specialized group of elderly surgical patients. TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trial Registry, UMIN000019832 . Registered on 18 November 2015.

  203. Differences in gray matter structure correlated to nationalism and patriotism. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Scientific reports　6　29912-29912　2016/07/15

    DOI： 10.1038/srep29912 　

    ISSN： 2045-2322

    More details Close

    Nationalism and patriotism both entail positive evaluations of one's nation. However, the former inherently involves derogation of other nations, whereas the latter is independent of comparisons with other nations. We used voxel-based morphometry and psychological measures and determined nationalism and patriotism's association with gray matter density (rGMD) and their cognitive nature in healthy individuals (433 men and 344 women; age, 20.7 ± 1.9 years) using whole-brain multiple regression analyses and post hoc analyses. We found higher nationalism associated with greater rGMD in (a) areas of the posterior cingulate cortex and greater rGMD in (b) the orbitofrontal cortex, and smaller rGMD in (c) the right amygdala area. Furthermore, we found higher patriotism associated with smaller rGMD in the (d) rostrolateral prefrontal cortex. Post hoc analyses revealed the mean rGMD of the cluster (a) associated with compassion, that of (b) associated with feeling of superiority, that of (c) associated with suicide ideation, and that of (d) associated with quality of life. These results indicate that individual nationalism may be mediated by neurocognitive mechanisms in social-related areas and limbic neural mechanisms, whereas patriotism may be mediated by neurocognitive mechanisms in areas related to well-being.

  204. OLIG2遺伝子多型(rs1059004)が脳白質の神経線維束の拡散異方性及び安静時脳灌流量に及ぼす効果の検討 Peer-reviewed

    小松 浩, 竹内 光, 菊地 淑恵, 小野 千晶, 坂井 舞, 小高 晃, 舩越 俊一, 大野 高志, 角藤 芳久, 高橋 雄太, 松岡 洋夫, 瀧 靖之, 川島 隆太, 富田 博秋

    精神神経学雑誌　(2016特別号)　S367-S367　2016/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  205. Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry Peer-reviewed

    Kotaro Hiraoka, Akira Sumiyoshi, Hiroi Nonaka, Takako Kikkawa, Ryuta Kawashima, Noriko Osumi

    PLOS ONE　11　(6)　2016/06

    DOI： 10.1371/journal.pone.0158153 　

    ISSN： 1932-6203

  206. Interpersonal frontopolar neural synchronization in group communication: An exploration toward fNIRS hyperscanning of natural interactions Peer-reviewed

    Takayuki Nozawa, Yukako Sasaki, Kohei Sakaki, Ryoichi Yokoyama, Ryuta Kawashima

    NEUROIMAGE　133　484-497　2016/06

    DOI： 10.1016/j.neuroimage.2016.03.059 　

    ISSN： 1053-8119

    eISSN： 1095-9572

  207. Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain Peer-reviewed

    Yui Mano, Ryuta Saito, Yoichi Haga, Tadao Matsunaga, Rong Zhang, Masashi Chonan, Shinya Haryu, Takuhiro Shoji, Aya Sato, Yukihiko Sonoda, Noriko Tsuruoka, Keisuke Nishiyachi, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Teiji Tominaga

    JOURNAL OF NEUROSURGERY　124　(5)　1490-1500　2016/05

    DOI： 10.3171/2015.3.JNS142152 　

    ISSN： 0022-3085

    eISSN： 1933-0693

  208. Reading Aloud and Solving Simple Arithmetic Calculation Intervention (Learning Therapy) Improves Inhibition, Verbal Episodic Memory, Focus Attention and Processing Speed in Healthy Elderly People: Evidence from a Randomized Controlled Trial. International-journal Peer-reviewed

    Nouchi R, Taki Y, Takeuchi H, Nozawa T, Sekiguchi A, Kawashima R

    Frontiers in human neuroscience　10　(MAY2016)　217-217　2016/05

    DOI： 10.3389/fnhum.2016.00217 　

    ISSN： 1662-5161

    More details Close

    BACKGROUND: Previous reports have described that simple cognitive training using reading aloud and solving simple arithmetic calculations, so-called "learning therapy", can improve executive functions and processing speed in the older adults. Nevertheless, it is not well-known whether learning therapy improve a wide range of cognitive functions or not. We investigated the beneficial effects of learning therapy on various cognitive functions in healthy older adults. METHODS: We used a single-blinded intervention with two groups (learning therapy group: LT and waiting list control group: WL). Sixty-four elderly were randomly assigned to LT or WL. In LT, participants performed reading Japanese aloud and solving simple calculations training tasks for 6 months. WL did not participate in the intervention. We measured several cognitive functions before and after 6 months intervention periods. RESULTS: Compared to WL, results revealed that LT improved inhibition performance in executive functions (Stroop: LT (Mean = 3.88) vs. WL (Mean = 1.22), adjusted p = 0.013 and reverse Stroop LT (Mean = 3.22) vs. WL (Mean = 1.59), adjusted p = 0.015), verbal episodic memory (Logical Memory (LM): LT (Mean = 4.59) vs. WL (Mean = 2.47), adjusted p = 0.015), focus attention (D-CAT: LT (Mean = 2.09) vs. WL (Mean = -0.59), adjusted p = 0.010) and processing speed compared to the WL control group (digit symbol coding: LT (Mean = 5.00) vs. WL (Mean = 1.13), adjusted p = 0.015 and Symbol Search (SS): LT (Mean = 3.47) vs. WL (Mean = 1.81), adjusted p = 0.014). DISCUSSION: This randomized controlled trial (RCT) can be showed the benefit of LT on inhibition of executive functions, verbal episodic memory, focus attention and processing speed in healthy elderly people. Our results were discussed under overlapping hypothesis.

  209. Parental Praise Correlates with Posterior Insular Cortex Gray Matter Volume in Children and Adolescents International-journal Peer-reviewed

    Matsudaira Izumi, Yokota Susumu, Hashimoto Teruo, Takeuchi Hikaru, Asano Kohei, Asano Michiko, Sassa Yuko, Taki Yasuyuki, Kawashima Ryuta

    PLOS ONE　11　(4)　e0154220　2016/04/21

    DOI： 10.1371/journal.pone.0154220 　

    ISSN： 1932-6203

  210. Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents Peer-reviewed

    Hashimoto Teruo, Fukui Kento, Takeuchi Hikaru, Yokota Susumu, Kikuchi Yoshie, Tomita Hiroaki, Taki Yasuyuki, Kawashima Ryuta

    CEREBRAL CORTEX　26　(4)　1795-1803　2016/04

    DOI： 10.1093/cercor/bhw020 　

    ISSN： 1047-3211

  211. RECOVERY FROM BRAIN VOLUME REDUCTION AND COGNITIVE DYSFUNCTIONS 6 MONTHS AFTER SURGERY IN PATIENTS WITH BREAST CANCER Peer-reviewed

    Sekiguchi Atsushi, Sato Chiho, Kawai Masaaki, Ishida Takanori, Taki Yasuyuki, Ohuchi Noriaki, Kawashima Ryuta

    PSYCHOSOMATIC MEDICINE　78　(3)　A73　2016/04

    ISSN： 0033-3174

  212. Neural correlates of second-language communication and the effect of language anxiety. International-journal Peer-reviewed

    Jeong H, Sugiura M, Suzuki W, Sassa Y, Hashizume H, Kawashima R

    Neuropsychologia　84　e2-12　2016/04

    ISSN： 0028-3932

    eISSN： 1873-3514

    More details Close

    Communicative speech is a type of language use that involves goal-directed action targeted at another person based on social interactive knowledge. Previous studies regarding one's first language (L1) have treated the theory of mind system, which is associated with understanding others, and the sensorimotor system, which is associated with action simulation, as important contributors to communication. However, little is known about the neural basis of communication in a second language (L2), which is limited in terms of its use as a communication tool. In this fMRI study, we manipulated the type of speech (i.e., communication vs. description) and the type of language (L1 vs. L2) to identify the specific brain areas involved in L2 communication. We also attempted to examine how the cortical mechanisms underlying L2 speech production are influenced by oral proficiency and anxiety regarding L2. Thirty native Japanese speakers who had learned English as an L2, performed communicative and descriptive speech-production tasks in both L1 and L2 while undergoing fMRI scanning. We found that the only the L2 communication task recruited the left posterior supramarginal gyrus (pSMG), which may be associated with the action simulation or prediction involved in generating goal-directed actions. Furthermore, the neural mechanisms underlying L2 communication, but not L2 description, were sensitive to both oral proficiency and anxiety levels; a) activation in the left middle temporal gyrus (MTG) increased as oral proficiency levels increased, and b) activation in the orbitofrontal cortex (OFC), including the left insula, decreased as L2 anxiety levels increased. These results reflect the successful retrieval of lexical information in a pragmatic context and an inability to monitor social behaviors due to anxiety. Taken together, the present results suggest that L2 communication relies on social skills and is mediated by anxiety and oral proficiency.

  213. Noninvasive targeting delivery and in vivo magnetic resonance tracking method for live apoptotic cells in cerebral ischemia with functional Fe2O3 magnetic nanoparticles Peer-reviewed

    Atsushi Saito, Moataz M. Mekawy, Akira Sumiyoshi, Jorge J. Riera, Hiroaki Shimizu, Ryuta Kawashima, Teiji Tominaga

    JOURNAL OF NANOBIOTECHNOLOGY　14　19　2016/03

    DOI： 10.1186/s12951-016-0173-1 　

    ISSN： 1477-3155

  214. High-gamma power changes after cognitive intervention: preliminary results from twenty-one senior adult subjects. International-journal Peer-reviewed

    Yoritaka Akimoto, Takayuki Nozawa, Akitake Kanno, Toshimune Kambara, Mizuki Ihara, Takeshi Ogawa, Takakuni Goto, Yasuyuki Taki, Ryoichi Yokoyama, Yuka Kotozaki, Rui Nouchi, Atsushi Sekiguchi, Hikaru Takeuchi, Carlos Makoto Miyauchi, Motoaki Sugiura, Eiichi Okumura, Takashi Sunda, Toshiyuki Shimizu, Eiji Tozuka, Satoru Hirose, Tatsuyoshi Nanbu, Ryuta Kawashima

    Brain and behavior　6　(3)　e00427-11　2016/03

    DOI： 10.1002/brb3.427 　

    ISSN： 2162-3279

    More details Close

    INTRODUCTION: Brain-imaging techniques have begun to be popular in evaluating the effectiveness of cognitive intervention training. Although gamma activities are rarely used as an index of training effects, they have several characteristics that suggest their potential suitability for this purpose. This pilot study examined whether cognitive training in elderly people affected the high-gamma activity associated with attentional processing and whether high-gamma power changes were related to changes in behavioral performance. METHODS: We analyzed (MEG) magnetoencephalography data obtained from 35 healthy elderly subjects (60-75 years old) who had participated in our previous intervention study in which the subjects were randomly assigned to one of the three types of intervention groups: Group V trained in a vehicle with a newly developed onboard cognitive training program, Group P trained with a similar program but on a personal computer, and Group C was trained to solve a crossword puzzle as an active control group. High-gamma (52-100 Hz) activity during a three-stimulus visual oddball task was measured before and after training. As a result of exclusion in the MEG data analysis stage, the final sample consisted of five subjects in Group V, nine subjects in Group P, and seven subjects in Group C. RESULTS: Results showed that high-gamma activities were differently altered between groups after cognitive intervention. In particular, members of Group V, who showed significant improvements in cognitive function after training, exhibited increased high-gamma power in the left middle frontal gyrus during top-down anticipatory target processing. High-gamma power changes in this region were also associated with changes in behavioral performance. CONCLUSIONS: Our preliminary results suggest the usefulness of high-gamma activities as an index of the effectiveness of cognitive training in elderly subjects.

  215. Basal ganglia correlates of fatigue in young adults. International-journal Peer-reviewed

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

    Scientific reports　6　21386-21386　2016/02/19

    DOI： 10.1038/srep21386 　

    More details Close

    Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.

  216. Effects of Sitting Posture in Bathtub Bathing on Joint Torque and Brain Activities

    KATO Tomohisa, SATO Minoru, MATSUSHITA Hiroyoshi, NOZAWA Takayuki, KAWASHIMA Ryuta

    Transactions of Japanese Society for Medical and Biological Engineering　54　(1)　22-27　2016

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.54.22 　

    ISSN： 1347-443X

    More details Close

    The purpose of this study was to investigate how the posture during bathtub bathing affects the body and mind. Although many studies discussed comfort and safety of bathing, little has been studied from the perspective of biomechanics and neuroscience. In our two experiments, we manipulated bathers' posture and measured changes in biomechanical loads (torque at joints) and cerebral blood flow in frontal brain regions. Additionally, we also collected subjective evaluation of physical relaxation for each posture. The results of experiments with male subjects in the 20 s to 30 s showed that extending legs, in comparison to flexing legs, induced a physically relaxed state, which was revealed by subjective evaluation. Furthermore, we found significant decrease of joint torque in the ankle and hip and a significant increases of joint torque in the knee when legs were extended than when flexed. Our measurements indicated inhibition of neural activity in the left ventrolateral prefrontal region during leg extension. These results motivate further exploration of the possibility that physical relaxation with a less confined bathing posture may induce "liberation from verbal thinking".

  217. Effects of Fast Simple Numerical Calculation Training on Neural Systems Peer-reviewed

    Hikaru Takeuchi, Tomomi Nagase, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Rui Nouchi, Ryuta Kawashima

    NEURAL PLASTICITY　2016　5940634　2016

    DOI： 10.1155/2016/5940634 　

    ISSN： 2090-5904

    eISSN： 1687-5443

  218. Human Cognitive Control Mode Estimation Using JINS MEME Peer-reviewed

    Takafumi Ogawa, Makoto Takahashi, Ryuta Kawashima

    IFAC PAPERSONLINE　49　(19)　331-336　2016

    DOI： 10.1016/j.ifacol.2016.10.571 　

    ISSN： 2405-8963

  219. The Experimental Study on the Ability to Manage Unexpected Events Using Micro-world Simulation Peer-reviewed

    Sohma Yoshitake, Yoshii Keito, Takahashi Makoto, Nakanowatari Hiroyuki, Yamamoto Yuki, Nejad Keyvan Kashkouli, Nozawa Takayuki, Sugiura Motoaki, Kawashima Ryuta

    IFAC PAPERSONLINE　49　(19)　480-485　2016

    DOI： 10.1016/j.ifacol.2016.10.635 　

    ISSN： 2405-8963

  220. Small Acute Benefits of 4 Weeks Processing Speed Training Games on Processing Speed and Inhibition Performance and Depressive Mood in the Healthy Elderly People: Evidence from a Randomized Control Trial. International-journal Peer-reviewed

    Nouchi Rui, Saito Toshiki, Nouchi Haruka, Kawashima Ryuta

    Frontiers in aging neuroscience　8　302-302　2016

    DOI： 10.3389/fnagi.2016.00302 　

    More details Close

    Background: Processing speed training using a 1-year intervention period improves cognitive functions and emotional states of elderly people. Nevertheless, it remains unclear whether short-term processing speed training such as 4 weeks can benefit elderly people. This study was designed to investigate effects of 4 weeks of processing speed training on cognitive functions and emotional states of elderly people. Methods: We used a single-blinded randomized control trial (RCT). Seventy-two older adults were assigned randomly to two groups: a processing speed training game (PSTG) group and knowledge quiz training game (KQTG) group, an active control group. In PSTG, participants were asked to play PSTG (12 processing speed games) for 15 min, during five sessions per week, for 4 weeks. In the KQTG group, participants were asked to play KQTG (four knowledge quizzes) for 15 min, during five sessions per week, for 4 weeks. We measured several cognitive functions and emotional states before and after the 4 week intervention period. Results: Our results revealed that PSTG improved performances in processing speed and inhibition compared to KQTG, but did not improve performance in reasoning, shifting, short term/working memory, and episodic memory. Moreover, PSTG reduced the depressive mood score as measured by the Profile of Mood State compared to KQTG during the 4 week intervention period, but did not change other emotional measures. Discussion: This RCT first provided scientific evidence related to small acute benefits of 4 week PSTG on processing speed, inhibition, and depressive mood in healthy elderly people. We discuss possible mechanisms for improvements in processing speed and inhibition and reduction of the depressive mood. Trial registration: This trial was registered in The University Hospital Medical Information Network Clinical Trials Registry (UMIN000022250).

  221. Impact of reading habit on white matter structure: Cross-sectional and longitudinal analyses. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

    NeuroImage　133　378-389　2016

    DOI： 10.1016/j.neuroimage.2016.03.037 　

    ISSN： 1053-8119

    More details Close

    Psychological studies showed the quantity of reading habit affects the development of their reading skills, various language skills, and knowledge. However, despite a vast amount of literature, the effects of reading habit on the development of white matter (WM) structures critical to language and reading processes have never been investigated. In this study, we used the fractional anisotropy (FA) measure of diffusion tensor imaging to measure WM microstructural properties and examined cross-sectional and longitudinal correlations between reading habit and FA of the WM bundles in a large sample of normal children. In both cross-sectional and longitudinal analyses, we found that greater strength of reading habit positively affected FA in the left arcuate fasciculus (AF), in the left inferior fronto-occipital fasciculus (IFOF), and in the left posterior corona radiata (PCR). Consistent with previous studies, we also confirmed the significance or a tendency for positive correlation between the strength of reading habit and the Verbal Comprehension score in cross-sectional and longitudinal analyses. These cross-sectional and longitudinal findings indicate that a healthy reading habit may be directly or indirectly associated with the advanced development of WM critical to reading and language processes. Future intervention studies are needed to determine the causal effects of reading habits on WM in normal children.

  222. The neural basis of the imitation drive. International-journal Peer-reviewed

    Sugiko Hanawa, Motoaki Sugiura, Takayuki Nozawa, Yuka Kotozaki, Yukihito Yomogida, Mizuki Ihara, Yoritaka Akimoto, Benjamin Thyreau, Shinichi Izumi, Ryuta Kawashima

    Social cognitive and affective neuroscience　11　(1)　66-77　2016/01

    DOI： 10.1093/scan/nsv089 　

    ISSN： 1749-5016

    More details Close

    Spontaneous imitation is assumed to underlie the acquisition of important skills by infants, including language and social interaction. In this study, functional magnetic resonance imaging (fMRI) was used to examine the neural basis of 'spontaneously' driven imitation, which has not yet been fully investigated. Healthy participants were presented with movie clips of meaningless bimanual actions and instructed to observe and imitate them during an fMRI scan. The participants were subsequently shown the movie clips again and asked to evaluate the strength of their 'urge to imitate' (Urge) for each action. We searched for cortical areas where the degree of activation positively correlated with Urge scores; significant positive correlations were observed in the right supplementary motor area (SMA) and bilateral midcingulate cortex (MCC) under the imitation condition. These areas were not explained by explicit reasons for imitation or the kinematic characteristics of the actions. Previous studies performed in monkeys and humans have implicated the SMA and MCC/caudal cingulate zone in voluntary actions. This study also confirmed the functional connectivity between Urge and imitation performance using a psychophysiological interaction analysis. Thus, our findings reveal the critical neural components that underlie spontaneous imitation and provide possible reasons why infants imitate spontaneously.

  223. Are Plasma Oxytocin and Vasopressin Levels Reflective of Amygdala Activation during the Processing of Negative Emotions? A Preliminary Study. International-journal Peer-reviewed

    Kosuke Motoki, Motoaki Sugiura, Hikaru Takeuchi, Yuka Kotozaki, Seishu Nakagawa, Ryoichi Yokoyama, Ryuta Kawashima

    Frontiers in psychology　7　480-480　2016

    DOI： 10.3389/fpsyg.2016.00480 　

    More details Close

    Plasma oxytocin (OT) and arginine vasopressin (AVP) are associated with individual differences in emotional responses and behaviors. The amygdala is considered to be an important brain region for regulating emotion-based behavior, with OT and AVP modulating activity in the amygdala during the processing of negative emotions. In particular, increased OT levels may diminish amygdala activation (anxiolytic effects) and enhanced AVP levels may augment amygdala activation (anxiogenic effects) when negative emotions are processed. A growing body of research has shown that the effects of OT and AVP are modulated by sex: the aforementioned anxiolytic effects of OT and the anxiogenic effects of AVP occur in men, but not in women. However, we have little knowledge regarding the biological mechanisms underlying OT and AVP plasma levels or their respective anxiogenic and anxiolytic effects; similarly, little is known about the causes and nature of sex differences related to these neuropeptides and their effects on emotional processing. In the current study, we focused on the neural functions associated with the biological mechanisms underlying such effects. We hypothesized that amygdala activation would correlate with trait plasma OT (anxiolytic effects) and AVP (anxiogenic effects) levels because the amygdala is thought to affect the coordinated release of these neuropeptides following affective experiences. We further hypothesized that the effects would be modulated by sex. We assessed 51 participants (male and female) using a paradigm involving negative emotion in conjunction with functional magnetic resonance imaging and measurements of plasma OT and AVP levels. We determined that increased plasma AVP levels were positively associated with amygdala activation (anxiogenic effects) in men, but not in women. These findings highlight the potential underlying neural mechanisms of plasma AVP levels in men.

  224. Sex-Related Differences in the Effects of Sleep Habits on Verbal and Visuospatial Working Memory. International-journal Peer-reviewed

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Frontiers in psychology　7　(JUL)　1128-1128　2016

    DOI： 10.3389/fpsyg.2016.01128 　

    ISSN： 1664-1078

    More details Close

    Poor sleep quality negatively affects memory performance, and working memory in particular. We investigated sleep habits related to sleep quality including sleep duration, daytime nap duration, nap frequency, and dream content recall frequency (DCRF). Declarative working memory can be subdivided into verbal working memory (VWM) and visuospatial working memory (VSWM). We hypothesized that sleep habits would have different effects on VWM and VSWM. To our knowledge, our study is the first to investigate differences between VWM and VSWM related to daytime nap duration, nap frequency, and DCRF. Furthermore, we tested the hypothesis that the effects of duration and frequency of daytime naps and DCRF on VWM and VSWM differed according to sex. We assessed 779 healthy right-handed individuals (434 males and 345 females; mean age: 20.7 ± 1.8 years) using a digit span forward and backward VWM task, a forward and backward VSWM task, and sleep habits scales. A correlation analysis was used to test the relationships between VWM capacity (VWMC) and VSWM capacity (VSWMC) scores and sleep duration, nap duration, nap frequency, and DCRF. Furthermore, multiple regression analyses were conducted to identify factors associated with VWMC and VSWMC scores and to identify sex-related differences. We found significant positive correlations between VSWMC and nap duration and DCRF, and between VWMC and sleep duration in all subjects. Furthermore, we found that working memory capacity (WMC) was positively correlated with nap duration in males and with sleep duration in females, and DCRF was positively correlated with VSWMC in females. Our finding of sex-related differences in the effects of sleep habits on WMC has not been reported previously. The associations between WMC and sleep habits differed according to sex because of differences in the underlying neural correlates of VWM and VSWM, and effectiveness of the sleep habits in males and females.

  225. The Associations between Regional Gray Matter Structural Changes and Changes of Cognitive Performance in Control Groups of Intervention Studies. International-journal Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R

    Frontiers in human neuroscience　9　(DEC)　681-681　2015/12

    DOI： 10.3389/fnhum.2015.00681 　

    ISSN： 1662-5161

    More details Close

    In intervention studies of cognitive training, the challenging cognitive tests, which were used as outcome measures, are generally completed in more than a few hours. Here, utilizing the control groups' data from three 1-week intervention studies in which young healthy adult subjects underwent a wide range of cognitive tests and T1-weighted magnetic resonance imaging (MRI) before and after the intervention period, we investigated how regional gray matter (GM) density (rGMD) of the subjects changed through voxel-based morphometry (VBM). Statistically significant increases in rGMD were observed in the anatomical cluster that mainly spread around the bilateral dorsal anterior cingulate cortex (dACC) and the right superior frontal gyrus (rSFG). Moreover, mean rGMD within this cluster changes were significantly and positively correlated with performance changes in the Stroop task, and tended to positively correlate with performance changes in a divergent thinking task. Affected regions are considered to be associated with performance monitoring (dACC) and manipulation of the maintained information including generating associations (rSFG), and both are relevant to the cognitive functions measured in the cognitive tests. Thus, the results suggest that even in the groups of the typical "control group" in intervention studies including those of the passive one, experimental or non-experimental factors can result in an increase in the regional GM structure and form the association between such neural changes and improvements related to these cognitive tests. These results suggest caution toward the experimental study designs without control groups.

  226. White matter structures associated with loneliness in young adults. International-journal Peer-reviewed

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Scientific reports　5　17001-17001　2015/11/20

    DOI： 10.1038/srep17001 　

    ISSN： 2045-2322

    More details Close

    Lonely individuals may exhibit dysfunction, particularly with respect to social empathy and self-efficacy. White matter (WM) structures related to loneliness have not yet been identified. We investigated the association between regional WM density (rWMD) using the UCLA Loneliness Scale in 776 healthy young students aged 18-27 years old. Loneliness scores were negatively correlated with rWMD in eight clusters: the bilateral inferior parietal lobule (IPL), right anterior insula (AI), posterior temporoparietal junction (pTPJ), left posterior superior temporal sulcus (pSTS), dorsomedial prefrontal cortex (dmPFC), and rostrolateral prefrontal cortex (RLPFC). The bilateral IPL, right AI, left pSTS, pTPJ, and RLPFC were strongly associated with Empathy Quotient (EQ), whereas the bilateral IPL, right AI, left pTPJ, and dmPFC were associated with General Self-Efficacy Scale (GSES) score. The neural correlates of loneliness comprise widespread reduction in WMD in areas related to self- and social cognition as well as areas associated with empathy and self-efficacy.

  227. Neural substrates underlying reconcentration for the preparation of an appropriate cognitive state to prevent future mistakes: A functional magnetic resonance imaging study Peer-reviewed

    Naoki Miura, Takayuki Nozawa, Makoto Takahashi, Ryoichi Yokoyama, Yukako Sasaki, Kohei Sakaki, Ryuta Kawashima

    Frontiers in Human Neuroscience　9　2015/11/03

    DOI： 10.3389/fnhum.2015.00603 　

    ISSN： 1662-5161

  228. Working memory training impacts the mean diffusivity in the dopaminergic system. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

    Brain structure & function　220　(6)　3101-11　2015/11

    DOI： 10.1007/s00429-014-0845-2 　

    ISSN： 1863-2661 1863-2653

    More details Close

    Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT) on dopamine receptor binding potentials, the effects of WMT on MD remain unknown. In this study, we investigated these effects in young adult subjects who either underwent WMT or received no intervention for 4 weeks. Before and after the intervention or no-intervention periods, subjects underwent scanning sessions in diffusion-weighted imaging to measure MD. Compared with no intervention, WMT resulted in an increase in MD in the bilateral caudate, right putamen, left dorsolateral prefrontal cortex (DLPFC), right anterior cingulate cortex (ACC), right substantia nigra, and ventral tegmental area. Furthermore, the increase in performance on WMT tasks was significantly positively correlated with the mean increase in MD in the clusters of the left DLPFC and of the right ACC. These results suggest that WMT caused microstructural changes in the regions of the dopaminergic system in a way that is usually interpreted as a reduction in neural components.

  229. Brain structures in the sciences and humanities. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Yuko Sassa, Ryuta Kawashima

    Brain structure & function　220　(6)　3295-305　2015/11

    DOI： 10.1007/s00429-014-0857-y 　

    ISSN： 1863-2661 1863-2653

    More details Close

    The areas of academic interest (sciences or humanities) and area of study have been known to be associated with a number of factors associated with autistic traits. However, despite the vast amount of literature on the psychological and physiological characteristics associated with faculty membership, brain structural characteristics associated with faculty membership have never been investigated directly. In this study, we used voxel-based morphometry to investigate differences in regional gray matter volume (rGMV)/regional white matter volume (rWMV) between science and humanities students to test our hypotheses that brain structures previously robustly shown to be altered in autistic subjects are related to differences in faculty membership. We examined 312 science students (225 males and 87 females) and 179 humanities students (105 males and 74 females). Whole-brain analyses of covariance revealed that after controlling for age, sex, and total intracranial volume, the science students had significantly larger rGMV in an anatomical cluster around the medial prefrontal cortex and the frontopolar area, whereas the humanities students had significantly larger rWMV in an anatomical cluster mainly concentrated around the right hippocampus. These anatomical structures have been linked to autism in previous studies and may mediate cognitive functions that characterize differences in faculty membership. The present results may support the ideas that autistic traits and characteristics of the science students compared with the humanities students share certain characteristics from neuroimaging perspectives. This study improves our understanding of differences in faculty membership which is the link among cognition, biological factors, disorders, and education (academia).

  230. Neuroanatomical correlates of the sense of control: Gray and white matter volumes associated with an internal locus of control. International-journal Peer-reviewed

    Teruo Hashimoto, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Ryuta Kawashima

    NeuroImage　119　146-51　2015/10/01

    DOI： 10.1016/j.neuroimage.2015.06.061 　

    ISSN： 1053-8119 1095-9572

    More details Close

    A belief that effort is rewarded can develop incentive, achievement motivation, and self-efficacy. Individuals with such a belief attribute causes of events to themselves, not to external, uncontrollable factors, and are thus said to have an internal locus of control. An internal locus of control is a positive personality trait and has been thoroughly studied in applied psychology, but has not been widely examined in neuroscience. In the present study, correlations between locus of control assessment scores and brain volumes were examined in 777 healthy young adults using magnetic resonance imaging. A whole-brain multiple regression analysis with corrections for the effects of age, gender, and intelligence was conducted. Voxel-based morphometry analyses revealed that gray matter volumes in the anterior cingulate cortex, striatum, and anterior insula positively correlated with higher scores, which indicate an internal LOC. In addition, white matter volumes in the striatum showed significant correlations with an internal locus of control. These results suggest that cognitive, socioemotional, self-regulatory, and reward systems might be associated with internal control orientation. The finding of greater volumes in several brain regions in individuals with a stronger internal locus of control indicates that there is a neuroanatomical basis for the belief that one's efforts are rewarded.

  231. Degree centrality and fractional amplitude of low-frequency oscillations associated with Stroop interference. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

    NeuroImage　119　197-209　2015/10/01

    DOI： 10.1016/j.neuroimage.2015.06.058 　

    ISSN： 1053-8119 1095-9572

    More details Close

    Stroop paradigms are commonly used as an index of attention deficits and a tool for investigating functions of the frontal lobes and other associated structures. Here we investigated the correlation between resting-state functional magnetic imaging (fMRI) measures [degree centrality (DC)/fractional amplitude of low frequency fluctuations (fALFFs)] and Stroop interference. We examined this relationship in the brains of 958 healthy young adults. DC reflects the number of instantaneous functional connections between a region and the rest of the brain within the entire connectivity matrix of the brain (connectome), and thus how much of the node influences the entire brain areas, while fALFF is an indicator of the intensity of regional brain spontaneous activity. Reduced Stroop interference was associated with larger DC in the left lateral prefrontal cortex, left IFJ, and left inferior parietal lobule as well as larger fALFF in the areas of the dorsal attention network and the precuneus. These findings suggest that Stroop performance is reflected in resting state functional properties of these areas and the network. In addition, default brain activity of the dorsal attention network and precuneus as well as higher cognitive processes represented there, and default stronger global influence of the areas critical in executive functioning underlie better Stroop performance.

  232. Amygdala and cingulate structure is associated with stereotype on sex-role. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Scientific reports　5　14220-14220　2015/09/30

    DOI： 10.1038/srep14220 　

    ISSN： 2045-2322

    More details Close

    Sex-role egalitarianism (SRE) is the belief that the sex of an individual should not influence the perception of his or her rights, abilities, obligations, and opportunities. Thus, low SRE reflects a more conservative stereotypical view on sex-role. Here we investigated anatomical correlates of individual differences in SRE in the present study. We used voxel-based morphometry, a questionnaire to determine an individual's SRE and associated psychological measures, and determined the association of SRE with gray matter structures and their cognitive nature in healthy individuals (375 men and 306 women; age, 20.6 ± 1.8 years). We demonstrated that higher SRE was associated with smaller regional gray matter density (rGMD) in the anterior part of the posterior cingulate cortex (PCC) and higher rGMD in the right amygdala. Post-hoc analyses revealed psychological measures characterized by contentious interpersonal orientations, such as contentious achievement motivation, were associated with lower SRE and higher rGMD in the anterior part of PCC. Depressive tendencies were associated with lower SRE and higher rGMD in the right amygdala. These findings suggest that variations in stereotype on sex role have roots in the limbic brain structures linked to contentious interpersonal orientation (cingulate) and negative mood (amygdala).

  233. Neural Mechanism for Mirrored Self-face Recognition. International-journal Peer-reviewed

    Motoaki Sugiura, Carlos Makoto Miyauchi, Yuka Kotozaki, Yoritaka Akimoto, Takayuki Nozawa, Yukihito Yomogida, Sugiko Hanawa, Yuki Yamamoto, Atsushi Sakuma, Seishu Nakagawa, Ryuta Kawashima

    Cerebral cortex (New York, N.Y. : 1991)　25　(9)　2806-14　2015/09

    DOI： 10.1093/cercor/bhu077 　

    ISSN： 1047-3211

    More details Close

    Self-face recognition in the mirror is considered to involve multiple processes that integrate 2 perceptual cues: temporal contingency of the visual feedback on one's action (contingency cue) and matching with self-face representation in long-term memory (figurative cue). The aim of this study was to examine the neural bases of these processes by manipulating 2 perceptual cues using a "virtual mirror" system. This system allowed online dynamic presentations of real-time and delayed self- or other facial actions. Perception-level processes were identified as responses to only a single perceptual cue. The effect of the contingency cue was identified in the cuneus. The regions sensitive to the figurative cue were subdivided by the response to a static self-face, which was identified in the right temporal, parietal, and frontal regions, but not in the bilateral occipitoparietal regions. Semantic- or integration-level processes, including amodal self-representation and belief validation, which allow modality-independent self-recognition and the resolution of potential conflicts between perceptual cues, respectively, were identified in distinct regions in the right frontal and insular cortices. The results are supportive of the multicomponent notion of self-recognition and suggest a critical role for contingency detection in the co-emergence of self-recognition and empathy in infants.

  234. An investigation of brain synchrony between students and their teacher during a secondary school EFL lesson Peer-reviewed

    Yamamoto R, Nozawa T, Jeong H, Ikeda S, Sakaki K, Kawashima R, Smith C, Ishikawa Y

    Breaking Theory: New Directions in Applied Linguistics, Proceedings of the 48th Annual Meeting of the British Association for Applied Linguistics, London. UK: Scitsiugnil Press　201-212　2015/09

  235. Regional gray matter density is associated with morningness-eveningness: Evidence from voxel-based morphometry. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    NeuroImage　117　294-304　2015/08/15

    DOI： 10.1016/j.neuroimage.2015.05.037 　

    ISSN： 1053-8119 1095-9572

    More details Close

    Diurnal preference (morningness-eveningness) is known to be associated with several individual characteristics that are important in the fields of sociology, education, and psychiatry. Despite this importance, the anatomical correlates of individual differences in morningness-eveningness are unknown, and these were investigated in the present study. We used voxel-based morphometry and a questionnaire to determine individual morningness-eveningness and its association with brain structures in 432 healthy men and 344 healthy women (age, 20.7±1.8years). We demonstrated that morningness (less eveningness) was associated with (a) lower regional gray matter density (rGMD) in the precuneus and adjacent areas, (b) lower rGMD in the left posterior parietal cortex and adjacent areas, and (c) higher rGMD in the bilateral orbitofrontal cortex. Further, our exploratory analyses revealed that (d) higher rGMD in hypothalamic areas around the bilateral suprachiasmatic nuclei were associated with morningness. These findings demonstrate that variations in morningness-eveningness reflect the GM structures of focal regions across the cortex, and suggest a structural basis for individual morningness-eveningness and its association with a wide range of psychological variables distributed across different GM areas of the brain.

  236. Individual differences in cognitive performance and brain structure in typically developing children International-journal Peer-reviewed

    Yokota Susumu, Takeuchi Hikaru, Hashimoto Teruo, Hashizume Hiroshi, Asano Kohei, Asano Michiko, Sassa Yuko, Taki Yasuyuki, Kawashima Ryuta

    DEVELOPMENTAL COGNITIVE NEUROSCIENCE　14　1-7　2015/08

    DOI： 10.1016/j.dcn.2015.05.003 　

    ISSN： 1878-9293

  237. 1-A-D-26. Pre-operative magnetoencephalographic spike localization in patients with surgically-cured epilepsy

    Makoto Ishida, Masaki Iwasaki, Akitake Kanno, Kazutaka Jin, Yosuke Kakisaka, Kazuhiro Kato, Ryuta Kawashima, Nobukazu Nakasato

    Clinical Neurophysiology　126　(6)　e57-e57　2015/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.clinph.2015.02.029 　

    ISSN： 1388-2457

  238. Sonority-related markedness drives the misperception of unattested onset clusters in French listeners Peer-reviewed

    Maïonchi-Pino N, Taki Y, Magnan A, Yokoyama S, Écalle J, Takahashi K, Hashizume H, Kawashima R

    L'Année psychologique　115　1-26　2015/06

    DOI： 10.4074/S0003503314000086 　

  239. 外科的に治療したてんかん患者における術前のMEG上でのスパイクの局在性(Pre-operative MEG spike localization in patients with surgically-cured epilepsy)

    Ishida Makoto, Iwasaki Masaki, Jin Kazutaka, Kanno Akitake, Asagi Suguru, Miki Takashi, Kawashima Ryuta, Nakasato Nobukazu

    医学検査　64　(別冊)　234-234　2015/05

    Publisher: (一社)日本臨床衛生検査技師会

    ISSN： 0915-8669

    eISSN： 2188-5346

  240. The impact of television viewing on brain structures: cross-sectional and longitudinal analyses. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

    Cerebral cortex (New York, N.Y. : 1991)　25　(5)　1188-97　2015/05

    DOI： 10.1093/cercor/bht315 　

    ISSN： 1047-3211

    More details Close

    Television (TV) viewing is known to affect children's verbal abilities and other physical, cognitive, and emotional development in psychological studies. However, the brain structural development associated with TV viewing has never been investigated. Here we examined cross-sectional correlations between the duration of TV viewing and regional gray/white matter volume (rGMV/rWMV) among 133 boys and 143 girls as well as correlations between the duration of TV viewing and longitudinal changes that occurred a few years later among 111 boys and 105 girls. After correcting for confounding factors, we found positive effects of TV viewing on rGMV of the frontopolar and medial prefrontal areas in cross-sectional and longitudinal analyses, positive effects of TV viewing on rGMV/rWMV of areas of the visual cortex in cross-sectional analyses, and positive effects of TV viewing on rGMV of the hypothalamus/septum and sensorimotor areas in longitudinal analyses. We also confirmed negative effects of TV viewing on verbal intelligence quotient (IQ) in cross-sectional and longitudinal analyses. These anatomical correlates may be linked to previously known effects of TV viewing on verbal competence, aggression, and physical activity. In particular, the present results showed effects of TV viewing on the frontopolar area of the brain, which has been associated with intellectual abilities.

  241. Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Hiroshi Hashizume, Rui Nouchi, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

    Human brain mapping　36　(5)　1808-27　2015/05

    DOI： 10.1002/hbm.22739 　

    ISSN： 1097-0193 1065-9471

    More details Close

    Recent investigations revealed mean diffusivity (MD) in gray matter and white matter areas is correlated with individual cognitive differences in healthy subjects and show unique properties and sensitivity that other neuroimaging tools donot have. In this study, we tested the hypothesis that the MD in the dopaminergic system is associated with individual differences in verbal creativity measured by divergent thinking (VCDT) and novelty seeking based on prior studies suggesting associations between these and dopaminergic functions. We examined this issue in a large sample of right-handed healthy young adults. We used analyses of MD and a psychological measure of VCDT, as well as personality measures of the Temperament and Character Inventory (TCI). Our results revealed associations between higher VCDT and lower MD in the bilateral globus pallidus. Furthermore, not only higher novelty seeking, but also lower harm avoidance, higher self-directedness, and higher self-transcendence were robustly associated with lower MD in the right globus pallidus, whereas higher persistence was associated with lower MD in the left globus pallidus. These personality variables were also associated with VCDT. The globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. These results suggested the MD in the globus pallidus, underlie the association between VCDT and multiple personalities in TCI including novelty seeking.

  242. Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele. International-journal Peer-reviewed

    Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    NeuroImage　110　124-35　2015/04/15

    DOI： 10.1016/j.neuroimage.2015.01.053 　

    ISSN： 1053-8119 1095-9572

    More details Close

    The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD) and substantially exists in Asian populations, which have a lower ADHD prevalence. In this study, we investigated the effect of this allele on microstructural properties of the brain and on its functional activity during externally directed attention-demanding tasks and creative performance in the 765 Asian subjects. For this purpose, we employed diffusion tensor imaging, N-back functional magnetic resonance imaging paradigms, and a test to measure creativity by divergent thinking. The 5-repeat allele was significantly associated with increased originality in the creative performance, increased mean diffusivity (the measure of how the tissue includes water molecules instead of neural and vessel components) in the widespread gray and white matter areas of extensive areas, particularly those where DRD4 is expressed, and reduced task-induced deactivation in the areas that are deactivated during the tasks in the course of both the attention-demanding working memory task and simple sensorimotor task. The observed neural characteristics of 5-repeat allele carriers may lead to an increased risk of ADHD and behavioral deficits. Furthermore, the increased originality of creative thinking observed in the 5-repeat allele carriers may support the notion of the side of adaptivity of the widespread risk allele of psychiatric diseases.

  243. Supramarginal activity in interoceptive attention tasks. International-journal Peer-reviewed

    Keyvan Kashkouli Nejad, Motoaki Sugiura, Takayuki Nozawa, Yuka Kotozaki, Yoshihito Furusawa, Kozo Nishino, Toshohiro Nukiwa, Ryuta Kawashima

    Neuroscience letters　589　42-6　2015/03/04

    DOI： 10.1016/j.neulet.2015.01.031 　

    ISSN： 0304-3940

    More details Close

    Interoceptive (feelings from inside organs) attention/awareness (IAA) is a body-related aspect of cognition that pursues homeostasis by detecting afferent signals, and there are practices aimed at focusing one's attention and awareness towards such feelings inside one's own body. There is a claim that these practices improve health which is one reason that neural correlates of such practices and IAA in general have been investigated in previous imaging studies. In several of these studies which used subjects with no or limited experience in IAA practices there was a report of supramarginal (SM) activity during IAA tasks, but the role of SM in IAA remain unclear. We first investigated if we could find similar results in novices, and if this activity is sensitive to the designated body part in the IAA task. We further investigated if these regions would be similarly recruited in subjects with extensive experience of IAA tasks while comparing results with a group of age and gender matched novices. Results in the novices replicated that of previous studies, and we showed this is the same for IAA tasks regarding two different parts of the body. Group comparison results showed opposite profiles of SM activation for the two groups; novices showed activation and the experts showed deactivation of the SM. The results suggest that novices recruit SM during IAA possibly due to lack of experience in those tasks but this could be alleviated for performing IAA as illustrated by activation profile in experts.

  244. Beneficial Effects of Exercise and Cognitive Training on Cognitive Functions in Older Adults: Introduction of Smart Aging Studies Peer-reviewed

    Rui Nouchi, Ryuta Kawashima

    Diet and Exercise in Cognitive Function and Neurological Diseases　205-212　2015/02/06

    Publisher: Wiley Blackwell

    DOI： 10.1002/9781118840634.ch18 　

  245. The impact of parent-child interaction on brain structures: cross-sectional and longitudinal analyses. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

    The Journal of neuroscience : the official journal of the Society for Neuroscience　35　(5)　2233-45　2015/02/04

    DOI： 10.1523/JNEUROSCI.0598-14.2015 　

    ISSN： 0270-6474

    More details Close

    There is a vast amount of evidence from psychological studies that the amount of parent-child interaction affects the development of children's verbal skills and knowledge. However, despite the vast amount of literature, brain structural development associated with the amount of parent-child interaction has never been investigated. In the present human study, we used voxel-based morphometry to measure regional gray matter density (rGMD) and examined cross-sectional correlations between the amount of time spent with parents and rGMD among 127 boys and 135 girls. We also assessed correlations between the amount of time spent with parents and longitudinal changes that occurred a few years later among 106 boys and 102 girls. After correcting for confounding factors, we found negative effects of spending time with parents on rGMD in areas in the bilateral superior temporal gyrus (STG) via cross-sectional analyses as well as in the contingent areas of the right STG. We also confirmed positive effects of spending time with parents on the Verbal Comprehension score in cross-sectional and longitudinal analyses. rGMD in partly overlapping or contingent areas of the right STG was negatively correlated with age and the Verbal Comprehension score in cross-sectional analyses. Subsequent analyses revealed verbal parent-child interactions have similar effects on Verbal Comprehension scores and rGMD in the right STG in both cross-sectional and longitudinal analyses. These findings indicate that parent-child interactions affect the right STG, which may be associated with verbal skills.

  246. The structure of the amygdala associates with human sexual permissiveness: evidence from voxel-based morphometry. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

    Human brain mapping　36　(2)　440-8　2015/02

    Publisher: 2

    DOI： 10.1002/hbm.22638 　

    ISSN： 1097-0193 1065-9471

    More details Close

    Sexual behavior is a critical function of human procreation. Despite previous studies that investigated the neural mechanisms of basic human physiological sexual functions, the neural mechanisms that underlie individual differences in human sexual permissiveness remain unknown. We used voxel-based morphometry and a questionnaire (scale for sexual attitudes) to measure sexual permissiveness to investigate the gray matter and white matter structural correlates of sexual permissiveness. Sexual permissiveness was negatively correlated with regional gray matter density of the structures involving the right amygdala and surrounding areas, and positively correlated with regional white matter density of the white matter area that spread around the left amygdala to the hypothalamus area. There were no gender-specific relationships in the neural correlates of our findings. These findings suggest that structural variations in regions that play key roles in the basic physiological aspects of human sexuality underlie individual complex sexual attitudes in social life.

  247. Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats. International-journal Peer-reviewed

    Hideaki Suzuki, Akira Sumiyoshi, Yasuharu Matsumoto, Ben A Duffy, Takeo Yoshikawa, Mark F Lythgoe, Kazuhiko Yanai, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Shimokawa

    NeuroImage　105　84-92　2015/01/15

    DOI： 10.1016/j.neuroimage.2014.10.040 　

    More details Close

    Heart failure (HF) is characterized by a blood supply which is insufficient to meet the body's demand. HF can potentially affect the brain and is associated with a high prevalence of depression. However, the mechanisms by which the two are related remain largely unclear. Structural abnormalities of the ventral hippocampus have been observed in depression but have never been reported in HF. In this study, we thus investigated structural brain abnormality in HF using voxel-based morphometry (VBM) and histological analysis in a rat model of HF. T2-weighted images were obtained in rats with HF (n = 20) and sham rats (n = 17) and VBM was used to produce gray matter concentration (GMC) maps. Twenty-four hour locomotor activity was used as a sign of depressive behavior. Brains of HF and sham rats (n = 8, each) were fixed and histologically analyzed for the measurement of neurogenesis, the number of astrocytes and neurite outgrowth in the ventral hippocampus. VBM demonstrated significant GMC decrease in the hippocampus, which was restricted to the ventral segment. Similarly, neurogenesis and neurite outgrowth were significantly decreased and the number of astrocytes was significantly increased in HF rats as compared with sham rats in the ventral hippocampus. GMC values in the ventral hippocampus were significantly and negatively correlated with 24 hour locomotor activity in HF rats. In conclusion, the present study has demonstrated for the first time that the structural abnormality of the ventral hippocampus is associated with depressive symptoms in HF rats.

  248. Comprehensive neural networks for guilty feelings in young adults. International-journal Peer-reviewed

    Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    NeuroImage　105　248-56　2015/01/15

    DOI： 10.1016/j.neuroimage.2014.11.004 　

    ISSN： 1053-8119 1095-9572

    More details Close

    Feelings of guilt are associated with widespread self and social cognitions, e.g., empathy, moral reasoning, and punishment. Neural correlates directly related to the degree of feelings of guilt have not been detected, probably due to the small numbers of subjects, whereas there are growing numbers of neuroimaging studies of feelings of guilt. We hypothesized that the neural networks for guilty feelings are widespread and include the insula, inferior parietal lobule (IPL), amygdala, subgenual cingulate cortex (SCC), and ventromedial prefrontal cortex (vmPFC), which are essential for cognitions of guilt. We investigated the association between regional gray matter density (rGMD) and feelings of guilt in 764 healthy young students (422 males, 342 females; 20.7 ± 1.8 years) using magnetic resonance imaging and the guilty feeling scale (GFS) for the younger generation which comprises interpersonal situation (IPS) and rule-breaking situation (RBS) scores. Both the IPS and RBS were negatively related to the rGMD in the right posterior insula (PI). The IPS scores were negatively correlated with rGMD in the left anterior insula (AI), right IPL, and vmPFC using small volume correction. A post hoc analysis performed on the significant clusters identified through these analyses revealed that rGMD activity in the right IPL showed a significant negative association with the empathy quotient. These findings at the whole-brain level are the widespread comprehensive neural network regions for guilty feelings. Interestingly, the novel finding in this study is that the PI was implicated as a common region for feelings of guilt with interaction between the IPS and RBS. Additionally, the neural networks including the IPL were associated with empathy and with regions implicated in moral reasoning (AI and vmPFC), and punishment (AI).

  249. SAIDO Learning as a Cognitive Intervention for Dementia Care: A Preliminary Study Peer-reviewed

    Ryuta Kawashima, Deborah Lewis Hiller, Sheryl L. Sereda, Michelle Antonczak, Kara Serger, Denise Gannon, Shinji Ito, Hiroshi Otake, Daisaku Yunomae, Akihito Kobayashi, Christopher Muller, Hiroyuki Murata, Stephanie FallCreek

    JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION　16　(1)　56-62　2015/01

    DOI： 10.1016/j.jamda.2014.10.021 　

    ISSN： 1525-8610

    eISSN： 1538-9375

  250. Development of eyewear to detect movement of eyes and body

    Kanoh Shin'ichiro, Ichi-nohe Susumu, Shioya Shunsuke, Inoue Kazutaka, Kawashima Ryuta

    Transactions of Japanese Society for Medical and Biological Engineering　53　S167_03-S167_03　2015

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.53.S167_03 　

    More details Close

    We have been developing the JINS MEME, an eyewear with a capability to detect eye and body movements. The horizontal and vertical EOG (electrooculogram) signals are measured and amplified with three metal dry electrodes placed near nasion and both sides of rhinion, of which positions correspond to the bridge and nose pads of eyewear, respectively. The user's mental states like drowsiness, fatigue, or interest to objects can be identified by the movements and blinking of the eyes extracted from the measured EOG. And the six-axis motion sensor (three-axis accelerometer and three-axis gyroscope) mounted in the eyewear measures the body motion. As the sensor located near the head is on the body axis, this eyewear is suitable to measure user's movement or shift of center of gravity during physical exercise with a high precision. The measured signals are used to extract various events of eye and body movement by the mounted MPU chip, or can be transmitted to the external devices via Bluetooth communication. In this presentation, the outline of the eyewear is introduced and some possible applications are shown.

  251. Disrupted white matter integrity in anterior corona radiata of patients with anorexia nervosa Peer-reviewed

    Y. Sato, E. Aizawa, A. Sekiguchi, Y. Kotozaki, M. Sugiura, Y. Taki, H. Hashizume, T. Kochiyama, R. Kawashima, S. Fukudo

    PSYCHOTHERAPY AND PSYCHOSOMATICS　84　(suppl 1)　62-62　2015

    ISSN： 0033-3190

    eISSN： 1423-0348

  252. Specific regions display altered grey matter volume in μ-opioid receptor knockout mice: MRI voxel-based morphometry. International-journal Peer-reviewed

    Kazumasu Sasaki, Akira Sumiyoshi, Hiroi Nonaka, Yoshiyuki Kasahara, Kazutaka Ikeda, F Scott Hall, George R Uhl, Masahiko Watanabe, Ryuta Kawashima, Ichiro Sora

    British journal of pharmacology　172　(2)　654-67　2015/01

    DOI： 10.1111/bph.12807 　

    More details Close

    BACKGROUND AND PURPOSE: μ Opioid receptor knockout (MOP-KO) mice display several behavioural differences from wild-type (WT) littermates including differential responses to nociceptive stimuli. Brain structural changes have been tied to behavioural alterations noted in transgenic mice with targeting of different genes. Hence, we assess the brain structure of MOP-KO mice. EXPERIMENTAL APPROACH: Magnetic resonance imaging (MRI) voxel-based morphometry (VBM) and histological methods were used to identify structural differences between extensively backcrossed MOP-KO mice and WT mice. KEY RESULTS: MOP-KO mice displayed robust increases in regional grey matter volume in olfactory bulb, several hypothalamic nuclei, periaqueductal grey (PAG) and several cerebellar areas, most confirmed by VBM analysis. The largest increases in grey matter volume were detected in the glomerular layer of the olfactory bulb, arcuate nucleus of hypothalamus, ventrolateral PAG (VLPAG) and cerebellar regions including paramedian and cerebellar lobules. Histological analyses confirm several of these results, with increased VLPAG cell numbers and increased thickness of the olfactory bulb granule cell layer and cerebellar molecular and granular cell layers. CONCLUSIONS AND IMPLICATIONS: MOP deletion causes previously undescribed structural changes in specific brain regions, but not in all regions with high MOP receptor densities (e.g. thalamus, nucleus accumbens) or that exhibit adult neurogenesis (e.g. hippocampus). Volume differences in hypothalamus and PAG may reflect behavioural changes including hyperalgesia. Although the precise relationship between volume change and MOP receptor deletion was not determined from this study alone, these findings suggest that levels of MOP receptor expression may influence a broader range of neural structure and function in humans than previously supposed. LINKED ARTICLES: This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2.

  253. Increased Posterior Hippocampal Volumes in Children with Lower Increase in Body Mass Index: A 3-Year Longitudinal MRI Study International-journal Peer-reviewed

    Hashimoto Teruo, Takeuchi Hikaru, Taki Yasuyuki, Yokota Susumu, Hashizume Hiroshi, Asano Kohei, Asano Michiko, Sassa Yuko, Nouchi Rui, Kawashima Ryuta

    DEVELOPMENTAL NEUROSCIENCE　37　(2)　153-160　2015

    DOI： 10.1159/000370064 　

    ISSN： 0378-5866

  254. Regional gray matter density associated with cognitive reflectivity-impulsivity: evidence from voxel-based morphometry. International-journal Peer-reviewed

    Ryoichi Yokoyama, Takayuki Nozawa, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Mayu Hanihara, Yuko Sassa, Ryuta Kawashima

    PloS one　10　(3)　e0122666　2015

    DOI： 10.1371/journal.pone.0122666 　

    ISSN： 1932-6203

    More details Close

    When faced with a problem or choice, humans can use two different strategies: "cognitive reflectivity," which involves slow responses and fewer mistakes, or "cognitive impulsivity," which comprises of quick responses and more mistakes. Different individuals use these two strategies differently. To our knowledge, no study has directly investigated the brain regions involved in reflectivity-impulsivity; therefore, this study focused on associations between these cognitive strategies and the gray matter structure of several brain regions. In order to accomplish this, we enrolled 776 healthy, right-handed individuals (432 men and 344 women; 20.7 ± 1.8 years) and used voxel-based morphometry with administration of a cognitive reflectivity-impulsivity questionnaire. We found that high cognitive reflectivity was associated with greater regional gray matter density in the ventral medial prefrontal cortex. Our finding suggests that this area plays an important role in defining an individual's trait associated with reflectivity and impulsivity.

  255. Effects of Different Types of Cognitive Training on Cognitive Function, Brain Structure, and Driving Safety in Senior Daily Drivers: A Pilot Study. International-journal Peer-reviewed

    Takayuki Nozawa, Yasuyuki Taki, Akitake Kanno, Yoritaka Akimoto, Mizuki Ihara, Ryoichi Yokoyama, Yuka Kotozaki, Rui Nouchi, Atsushi Sekiguchi, Hikaru Takeuchi, Carlos Makoto Miyauchi, Takeshi Ogawa, Takakuni Goto, Takashi Sunda, Toshiyuki Shimizu, Eiji Tozuka, Satoru Hirose, Tatsuyoshi Nanbu, Ryuta Kawashima

    Behavioural neurology　2015　525901-525901　2015

    DOI： 10.1155/2015/525901 　

    ISSN： 1875-8584 0953-4180

    More details Close

    BACKGROUND: Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS: Thirty-seven healthy elderly daily drivers were randomly assigned to one of three training groups: Group V trained in a vehicle with a newly developed onboard cognitive training program, Group P trained with a similar program but on a personal computer, and Group C trained to solve a crossword puzzle. Before and after the 8-week training period, they underwent neuropsychological tests, structural brain magnetic resonance imaging, and driving safety tests. RESULTS: For cognitive function, only Group V showed significant improvements in processing speed and working memory. For driving safety, Group V showed significant improvements both in the driving aptitude test and in the on-road evaluations. Group P showed no significant improvements in either test, and Group C showed significant improvements in the driving aptitude but not in the on-road evaluations. CONCLUSION: The results support the effectiveness of the onboard training program in enhancing the elderly's abilities to drive safely and the potential advantages of a multimodal training approach.

  256. The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. International-journal Peer-reviewed

    Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Frontiers in psychology　6　912-912　2015

    DOI： 10.3389/fpsyg.2015.00912 　

    More details Close

    Previous neuroscientific studies have shown that the dopaminergic system plays an important role in creative potential measured by divergent thinking (CPMDT), emotional control, and motivational state. However, although associations between two of these four components have been previously established (e.g., the association between CPMDT and emotional control, the association between CPMDT and motivational state, etc.), the interactions between these four remain unknown. The purpose of this study was to reveal these interactions using path analyses. The Taq1A polymorphism of the dopamine D2 receptor (DRD2) gene was used for this purpose. For measuring emotional intelligence (EI), we used the Japanese version of the Emotional Intelligence Scale. CPMDT was measured using the S-A creativity test. Motivational state was measured using the Vigor subscale of the Japanese version of the Profile of Mood Scale (POMS). Data from 766 healthy, right-handed individuals (426 men and 340 women; 20.7 ± 1.9 years of age) were used in this study. There were significant and robust positive relationships among measures of CPMDT, EI, and motivational state across sex. In addition, the polymorphism of the DRD2 gene was significantly associated with EI, specifically in females. Path analysis in females indicates that the model in which (a) the DRD2 polymorphism primarily facilitates EI, (b) EI in turn facilitates CPMDT and leads to a better motivational state, and (c) a better motivational state also directly facilitates CPMDT explains the data in the most accurate manner. This study suggested a comprehensive picture of the cascade of the associations among dopamine, EI, motivational state, and CPMDT at least in females.

  257. The Relationship between Processing Speed and Regional White Matter Volume in Healthy Young People. International-journal Peer-reviewed

    Daniele Magistro, Hikaru Takeuchi, Keyvan Kashkouli Nejad, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Yuko Sassa, Ryuta Kawashima

    PloS one　10　(9)　e0136386　2015

    DOI： 10.1371/journal.pone.0136386 　

    ISSN： 1932-6203

    More details Close

    Processing speed is considered a key cognitive resource and it has a crucial role in all types of cognitive performance. Some researchers have hypothesised the importance of white matter integrity in the brain for processing speed; however, the relationship at the whole-brain level between white matter volume (WMV) and processing speed relevant to the modality or problem used in the task has never been clearly evaluated in healthy people. In this study, we used various tests of processing speed and Voxel-Based Morphometry (VBM) analyses, it is involves a voxel-wise comparison of the local volume of gray and white, to assess the relationship between processing speed and regional WMV (rWMV). We examined the association between processing speed and WMV in 887 healthy young adults (504 men and 383 women; mean age, 20.7 years, SD, 1.85). We performed three different multiple regression analyses: we evaluated rWMV associated with individual differences in the simple processing speed task, word-colour and colour-word tasks (processing speed tasks with words) and the simple arithmetic task, after adjusting for age and sex. The results showed a positive relationship at the whole-brain level between rWMV and processing speed performance. In contrast, the processing speed performance did not correlate with rWMV in any of the regions examined. Our results support the idea that WMV is associated globally with processing speed performance regardless of the type of processing speed task.

  258. Postoperative Structural Brain Changes and Cognitive Dysfunction in Patients with Breast Cancer. International-journal Peer-reviewed

    Chiho Sato, Atsushi Sekiguchi, Masaaki Kawai, Yuka Kotozaki, Rui Nouchi, Hiroshi Tada, Hikaru Takeuchi, Takanori Ishida, Yasuyuki Taki, Ryuta Kawashima, Noriaki Ohuchi

    PloS one　10　(11)　e0140655　2015

    DOI： 10.1371/journal.pone.0140655 　

    ISSN： 1932-6203

    More details Close

    OBJECTIVE: The primary purpose of this study was to clarify the influence of the early response to surgery on brain structure and cognitive function in patients with breast cancer. It was hypothesized that the structure of the thalamus would change during the early response after surgery due to the effects of anesthesia and would represent one aspect of an intermediate phenotype of postoperative cognitive dysfunction (POCD). METHODS: We examined 32 postmenopausal females with breast cancer and 20 age-matched controls. We assessed their cognitive function (attention, memory, and executive function), and performed brain structural MRI 1.5 ± 0.5 days before and 5.6 ± 1.2 days after surgery. RESULTS: We found a significant interaction between regional grey matter volume (rGMV) in the thalamus (P < 0.05, familywise error (FWE), small volume correction (SVC)) and one attention domain subtest (P = 0.001, Bonferroni correction) after surgery in the patient group compared with the control group. Furthermore, the changes in attention were significantly associated with sevoflurane anesthetic dose (r2 = 0.247, β = ‒0.471, P = 0.032) and marginally associated with rGMV changes in the thalamus (P = 0.07, FWE, SVC) in the Pt group. CONCLUSION: Our findings suggest that alterations in brain structure, particularly in the thalamus, may occur shortly after surgery and may be associated with attentional dysfunction. This early postoperative response to anesthesia may represent an intermediate phenotype of POCD. It was assumed that patients experiencing other risk factors of POCD, such as the severity of surgery, the occurrence of complications, and pre-existing cognitive impairments, would develop clinical POCD with broad and multiple types of cognitive dysfunction.

  259. Temporal and Motor Representation of Rhythm in Fronto-Parietal Cortical Areas: An fMRI Study. International-journal Peer-reviewed

    Naho Konoike, Yuka Kotozaki, Hyeonjeong Jeong, Atsuko Miyazaki, Kohei Sakaki, Takamitsu Shinada, Motoaki Sugiura, Ryuta Kawashima, Katsuki Nakamura

    PloS one　10　(6)　e0130120　2015

    DOI： 10.1371/journal.pone.0130120 　

    More details Close

    When sounds occur with temporally structured patterns, we can feel a rhythm. To memorize a rhythm, perception of its temporal patterns and organization of them into a hierarchically structured sequence are necessary. On the other hand, rhythm perception can often cause unintentional body movements. Thus, we hypothesized that rhythm information can be manifested in two different ways; temporal and motor representations. The motor representation depends on effectors, such as the finger or foot, whereas the temporal representation is effector-independent. We tested our hypothesis with a working memory paradigm to elucidate neuronal correlates of temporal or motor representation of rhythm and to reveal the neural networks associated with these representations. We measured brain activity by fMRI while participants memorized rhythms and reproduced them by tapping with the right finger, left finger, or foot, or by articulation. The right inferior frontal gyrus and the inferior parietal lobule exhibited significant effector-independent activations during encoding and retrieval of rhythm information, whereas the left inferior parietal lobule and supplementary motor area (SMA) showed effector-dependent activations during retrieval. These results suggest that temporal sequences of rhythm are probably represented in the right fronto-parietal network, whereas motor sequences of rhythm can be represented in the SMA-parietal network.

  260. Neural correlates of second-language communication and the effect of language anxiety. Peer-reviewed

    Jeong H, Sugiura M, Suzuki W, Sassa Y, Hashizume H, Kawashima R

    Neuropsychologia　66　182-192　2015/01

    DOI： 10.1016/j.neuropsychologia.2014.11.013 　

    ISSN： 0028-3932

    eISSN： 1873-3514

  261. Adaptive ability to cope with atypical or novel situations involving tool use: an fMRI approach. Peer-reviewed

    Wakusawa K, Sugiura M, Sassa Y, Jeong H, Yomogida Y, Horie K, Sato S, Yokoyama H, Kure S, Takei N, Mori N, Kawashima R

    Neuroscience research　90　72-82　2015/01

    DOI： 10.1016/j.neures.2014.03.008 　

    ISSN： 0168-0102

  262. Electro- and magneto-encephalographic spike source localization of small focal cortical dysplasia in the dorsal peri-rolandic region. International-journal Peer-reviewed

    Hisashi Itabashi, Kazutaka Jin, Masaki Iwasaki, Eiichi Okumura, Akitake Kanno, Kazuhiro Kato, Teiji Tominaga, Ryuta Kawashima, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　125　(12)　2358-63　2014/12

    DOI： 10.1016/j.clinph.2014.02.028 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  263. Applying a cognitive training program using a brain training game to patients with schizophrenia: study protocol for a randomized trial Peer-reviewed

    Kunio Iizuka, Kazunori Matsumoto, Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Takayuki Nozawa, Hiroshi Hashizume, Ryoichi Yokoyama, Yukako Sasaki, Chika Obara, Hiroo Matsuoka, Ryuta Kawashima

    EARLY INTERVENTION IN PSYCHIATRY　8　145-145　2014/11

    ISSN： 1751-7885

    eISSN： 1751-7893

  264. Correlations between brain structures and study time at home in healthy children: a longitudinal analysis Peer-reviewed

    Michiko Asano, Yasuyuki Taki, Hiroshi Hashizume, Hikaru Takeuchi, Benjamin Thyreau, Yuko Sassa, Ryuta Kawashima

    BRAIN AND BEHAVIOR　4　(6)　801-811　2014/11

    DOI： 10.1002/brb3.278 　

    ISSN： 2162-3279

  265. High-gamma activity in an attention network predicts individual differences in elderly adults' behavioral performance Peer-reviewed

    Akimoto Yoritaka, Nozawa Takayuki, Kanno Akitake, Ihara Mizuki, Goto Takakuni, Ogawa Takeshi, Kambara Toshimune, Sugiura Motoaki, Okumura Eiichi, Kawashima Ryuta

    NEUROIMAGE　100　290-300　2014/10/15

    DOI： 10.1016/j.neuroimage.2014.06.037 　

    ISSN： 1053-8119

  266. Association between resting-state functional connectivity and empathizing/systemizing. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

    NeuroImage　99　312-22　2014/10/01

    DOI： 10.1016/j.neuroimage.2014.05.031 　

    ISSN： 1053-8119 1095-9572

    More details Close

    Empathizing is the drive to identify the mental status of other individuals and respond to it with an appropriate emotion; systemizing is the drive to analyze a system. Previously, we have shown that structures associated with the default mode network (DMN) and external attention system (EAS) are associated with empathizing and systemizing, respectively. Here we investigated the association between resting-state functional connectivity (RSFC) and empathizing/systemizing in 248 healthy young adults. We considered the medial prefrontal cortex (mPFC) and bilateral dorsolateral prefrontal cortices (DLPFCs), which are key nodes of DMN and EAS, as seed regions, and investigated correlations across subjects between individual empathizing/systemizing and RSFC between each seed region and other brain regions. We found that higher empathizing was associated with larger RSFC between the mPFC and areas in (a) the dorsal anterior cingulate cortex (dACC), (b) precuneus, and (c) left superior temporal sulcus (STS). Furthermore, there was an interaction effect between sex and systemizing on RSFC between the left DLPFC and dACC: males showed positive correlations between this RSFC and systemizing, whereas females showed the opposite tendency. Thus, empathizing was associated with increased positive functional coupling with the key node and other nodes of DMN, as well as the area associated with feeling another's pain. Systemizing was associated with increased positive functional coupling between the key nodes of EAS in males. These findings provide further support for the concept of an association between DMN/EAS and empathizing/systemizing.

  267. Regional gray matter volume increases following 7days of voluntary wheel running exercise: a longitudinal VBM study in rats. Peer-reviewed

    Sumiyoshi A, Taki Y, Nonaka H, Takeuchi H, Kawashima R

    NeuroImage　98　82-90　2014/09

    DOI： 10.1016/j.neuroimage.2014.04.075 　

    ISSN： 1053-8119

  268. From social-signal detection to higher social cognition: an fMRI approach. Peer-reviewed

    Sugiura M, Yomogida Y, Mano Y, Sassa Y, Kambara T, Sekiguchi A, Kawashima R

    Social cognitive and affective neuroscience　9　(9)　1303-1309　2014/09

    Publisher: 9

    DOI： 10.1093/scan/nst119 　

    ISSN： 1749-5024 1749-5016

    eISSN： 1749-5024

  269. Fatigue and relating to others 3 months after the 2011 Great East Japan Earthquake. International-journal Peer-reviewed

    Seishu Nakagawa, Motoaki Sugiura, Atsushi Sekiguchi, Yuka Kotozaki, Tsuyoshi Araki, Sugiko Hanawa, Carlos Makoto Miyauchi, Atsushi Sakuma, Ryuta Kawashima

    Psychiatry research　218　(3)　324-8　2014/08/30

    Publisher: 3

    DOI： 10.1016/j.psychres.2014.04.043 　

    ISSN： 1872-7123 0165-1781

    More details Close

    Most inhabitants of Tohoku district suffer from chronic fatigue after the 2011 Great East Japan Earthquake. Chronic fatigue following disasters may lead to serious illness, even death. Posttraumatic growth appears to counteract fatigue. We predicted that the chronic fatigue would be inversely related to the posttraumatic growth factor "relating to others," as represented by mutual helping and a strong sense of connection with humanity. Young 59 healthy volunteers, residing in Miyagi prefecture, were recruited 3 months after the disaster. We measured the subjects׳ total scores on the Japanese version of the Checklist Individual Strength questionnaire (CIS), the Trait Anxiety (T-A) subscale of the State-Trait Anxiety Inventory (STAI), the Center for Epidemiologic Studies Depression Scale (CES-D), and four subscores on the posttraumatic growth inventory (PTGI). Stepwise regression analyses were conducted with score on the CIS as the dependent variable and other scores as independent variables. Scores on the "relating to others" factor of the PTGI showed a significant negative relationship with the CIS score, whereas the scores on the T-A subscale of the STAI and the CES-D were positively related to the CIS score. Human ties and mutual help were negatively related to the degree of the chronic fatigue.

  270. Improving cognitive function from children to old age: A systematic review of recent smart ageing intervention studies

    Rui Nouchi, Ryuta Kawashima

    Advances in neuroscience　2014/08/11

    DOI： 10.1155/2014/235479 　

  271. Healthy children show gender differences in correlations between nonverbal cognitive ability and brain activation during visual perception. International-journal Peer-reviewed

    Asano K, Taki Y, Hashizume H, Sassa Y, Thyreau B, Asano M, Takeuchi H, Kawashima R

    Neuroscience letters　577　66-71　2014/08

    DOI： 10.1016/j.neulet.2014.06.015 　

    ISSN： 0304-3940

    More details Close

    Humans perceive textual and nontextual information in visual perception, and both depend on language. In childhood education, students exhibit diverse perceptual abilities, such that some students process textual information better and some process nontextual information better. These predispositions involve many factors, including cognitive ability and learning preference. However, the relationship between verbal and nonverbal cognitive abilities and brain activation during visual perception has not yet been examined in children. We used functional magnetic resonance imaging to examine the relationship between nonverbal and verbal cognitive abilities and brain activation during nontextual visual perception in large numbers of children. A significant positive correlation was found between nonverbal cognitive abilities and brain activation in the right temporoparietal junction, which is thought to be related to attention reorienting. This significant positive correlation existed only in boys. These findings suggested that male brain activation differed from female brain activation, and that this depended on individual cognitive processes, even if there was no gender difference in behavioral performance.

  272. Effects of multitasking-training on gray matter structure and resting state neural mechanisms. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

    Human brain mapping　35　(8)　3646-60　2014/08

    Publisher: 8

    DOI： 10.1002/hbm.22427 　

    ISSN： 1097-0193 1065-9471

    More details Close

    Multitasking (MT) constitutes engaging in two or more cognitive activities at the same time. MT-training improves performance on untrained MT tasks and alters the functional activity of the brain during MT. However, the effects of MT-training on neural mechanisms beyond MT-related functions are not known. We investigated the effects of 4 weeks of MT-training on regional gray matter volume (rGMV) and functional connectivity during rest (resting-FC) in young human adults. MT-training was associated with increased rGMV in three prefrontal cortical regions (left lateral rostral prefrontal cortex (PFC), dorsolateral PFC (DLPFC), and left inferior frontal junction), the left posterior parietal cortex, and the left temporal and lateral occipital areas as well as decreased resting-FC between the right DLPFC and an anatomical cluster around the ventral anterior cingulate cortex (ACC). Our findings suggest that participation in MT-training is as a whole associated with task-irrelevant plasticity (i.e., neural changes are not limited to certain specific task conditions) in regions and the network that are assumed to play roles in MT as well as diverse higher-order cognitive functions. We could not dissociate the effects of each task component and the diverse cognitive processes involved in MT because of the nature of the study, and these remain to be investigated.

  273. Developmental changes in brain activation involved in the production of novel speech sounds in children. International-journal Peer-reviewed

    Hiroshi Hashizume, Yasuyuki Taki, Yuko Sassa, Benjamin Thyreau, Michiko Asano, Kohei Asano, Hikaru Takeuchi, Rui Nouchi, Yuka Kotozaki, Hyeonjeong Jeong, Motoaki Sugiura, Ryuta Kawashima

    Human brain mapping　35　(8)　4079-89　2014/08

    DOI： 10.1002/hbm.22460 　

    ISSN： 1065-9471

    More details Close

    Older children are more successful at producing unfamiliar, non-native speech sounds than younger children during the initial stages of learning. To reveal the neuronal underpinning of the age-related increase in the accuracy of non-native speech production, we examined the developmental changes in activation involved in the production of novel speech sounds using functional magnetic resonance imaging. Healthy right-handed children (aged 6-18 years) were scanned while performing an overt repetition task and a perceptual task involving aurally presented non-native and native syllables. Productions of non-native speech sounds were recorded and evaluated by native speakers. The mouth regions in the bilateral primary sensorimotor areas were activated more significantly during the repetition task relative to the perceptual task. The hemodynamic response in the left inferior frontal gyrus pars opercularis (IFG pOp) specific to non-native speech sound production (defined by prior hypothesis) increased with age. Additionally, the accuracy of non-native speech sound production increased with age. These results provide the first evidence of developmental changes in the neural processes underlying the production of novel speech sounds. Our data further suggest that the recruitment of the left IFG pOp during the production of novel speech sounds was possibly enhanced due to the maturation of the neuronal circuits needed for speech motor planning. This, in turn, would lead to improvement in the ability to immediately imitate non-native speech.

  274. Regional gray matter volume increases following 7 days of voluntary wheel running exercise: A longitudinal VBM study in rats Peer-reviewed

    Sumiyoshi A, Taki Y, Nonaka H, Takeuchi H, Kawashima R

    Neuroimage　61　(4)　1206-1212　2014/07

    DOI： 10.1016/j.neuroimage.2012.04.010 　

    More details Close

    July 16

  275. Biofeedback-based training for stress management in daily hassles: an intervention study. International-journal Peer-reviewed

    Yuka Kotozaki, Hikaru Takeuchi, Atsushi Sekiguchi, Yuki Yamamoto, Takamitsu Shinada, Tsuyoshi Araki, Kei Takahashi, Yasuyuki Taki, Takeshi Ogino, Masashi Kiguchi, Ryuta Kawashima

    Brain and behavior　4　(4)　566-79　2014/07

    Publisher: 4

    DOI： 10.1002/brb3.241 　

    ISSN： 2162-3279

    More details Close

    BACKGROUND: The day-to-day causes of stress are called daily hassles. Daily hassles are correlated with ill health. Biofeedback (BF) is one of the tools used for acquiring stress-coping skills. However, the anatomical correlates of the effects of BF with long training periods remain unclear. In this study, we aimed to investigate this. METHODS: PARTICIPANTS WERE ASSIGNED RANDOMLY TO TWO GROUPS: the intervention group and the control group. Participants in the intervention group performed a biofeedback training (BFT) task (a combination task for heart rate and cerebral blood flow control) every day, for about 5 min once a day. The study outcomes included MRI, psychological tests (e.g., Positive and Negative Affect Schedule, Center for Epidemiologic Studies Depression Scale, and Brief Job Stress Questionnaire), and a stress marker (salivary cortisol levels) before (day 0) and after (day 28) the intervention. RESULTS: We observed significant improvements in the psychological test scores and salivary cortisol levels in the intervention group compared to the control group. Furthermore, voxel-based morphometric analysis revealed that compared to the control group, the intervention group had significantly increased regional gray matter (GM) volume in the right lateral orbitofrontal cortex, which is an anatomical cluster that includes mainly the left hippocampus, and the left subgenual anterior cingulate cortex. The GM regions are associated with the stress response, and, in general, these regions seem to be the most sensitive to the detrimental effects of stress. CONCLUSIONS: Our findings suggest that our BFT is effective against the GM structures vulnerable to stress.

  276. Effects of Contralateral Noise on the 20-Hz Auditory Steady State Response - Magnetoencephalography Study Peer-reviewed

    Hajime Usubuchi, Tetsuaki Kawase, Akitake Kanno, Izumi Yahata, Hiromitsu Miyazaki, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

    PLOS ONE　9　(6)　e99457　2014/06

    DOI： 10.1371/journal.pone.0099457 　

    ISSN： 1932-6203

  277. The Neural Basis of Event Simulation: An fMRI Study Peer-reviewed

    Yomogida Yukihito, Sugiura Motoaki, Akimoto Yoritaka, Miyauchi Carlos Makoto, Kawashima Ryuta

    PLOS ONE　9　(5)　2014/05/02

    DOI： 10.1371/journal.pone.0096534 　

    ISSN： 1932-6203

  278. The neural bases underlying social risk perception in purchase decisions Peer-reviewed

    Yokoyama Ryoichi, Nozawa Takayuki, Sugiura Motoaki, Yomogida Yukihito, Takeuchi Hikaru, Akimoto Yoritaka, Shibuya Satoru, Kawashima Ryuta

    NEUROIMAGE　91　120-128　2014/05/01

    DOI： 10.1016/j.neuroimage.2014.01.036 　

    ISSN： 1053-8119

  279. Anatomical correlates of quality of life: evidence from voxel-based morphometry. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Yuko Sassa, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Tomomi Nagase, Carlos Makoto Miyauchi, Ryuta Kawashima

    Human brain mapping　35　(5)　1834-46　2014/05

    Publisher: 5

    DOI： 10.1002/hbm.22294 　

    ISSN： 1097-0193 1065-9471

    More details Close

    Quality of life (QOL) has been defined in many ways, and these definitions usually emphasize happiness and satisfaction with life. Health-related problems are known to cause lower QOL. However, the neural mechanisms underlying individual differences in QOL measured by questionnaire (QOLMQ) in young healthy subjects are unknown. QOL is essential to our well-being, and investigation of the neural mechanisms underlying QOL in uncompromised subjects is obviously of great scientific and social interest. We used voxel-based morphometry to investigate the association between regional gray matter volume (rGMV) and QOLMQ across the brain in healthy young adults (age, 21.4 ± 1.8 years) men (n = 88) and women (n = 68) in humans. We found significant negative relationships between QOLMQ and rGMV in a region in the left rostrolateral prefrontal cortex and regions in the dorsal part of the anterior cingulate gyrus and contingent cingulate regions. These findings show that structural variations in regions associated with processing of negative emotions such as fear and anger as well as those associated with evaluation of internally generated information are associated with QOLMQ. These findings suggest that these processes might be related to QOLMQ in healthy young adults.

  280. Irony Comprehension: Social Conceptual Knowledge and Emotional Response Peer-reviewed

    Akimoto Yoritaka, Sugiura Motoaki, Yomogida Yukihito, Miyauchi Carlos Makoto, Miyazawa Shiho, Kawashima Ryuta

    HUMAN BRAIN MAPPING　35　(4)　1167-1178　2014/04

    DOI： 10.1002/hbm.22242 　

    ISSN： 1065-9471

  281. NEURAL UNDERPINNINGS OF POSTOPERATIVE COGNITIVE DYSFUNCTIONS (POCD) IN PATIENTS WITH BREAST CANCER Peer-reviewed

    Sato Chiho, Sekiguchi Atsushi, Kotozaki Yuka, Nouchi Rui, Takeuchi Hikaru, Taki Yasuyuki, Kawai Masaaki, Tada Hiroshi, Ishida Takanori, Kawashima Ryuta, Ohuchi Noriaki

    PSYCHOSOMATIC MEDICINE　76　(3)　A29　2014/04

    ISSN： 0033-3174

  282. Four weeks of combination exercise training improved executive functions, episodic memory, and processing speed in healthy elderly people: evidence from a randomized controlled trial. International-journal Peer-reviewed

    Nouchi R, Taki Y, Takeuchi H, Sekiguchi A, Hashizume H, Nozawa T, Nouchi H, Kawashima R

    Age (Dordrecht, Netherlands)　36　(2)　787-799　2014/04

    Publisher: 2

    DOI： 10.1007/s11357-013-9588-x 　

    ISSN： 1574-4647 0161-9152

    More details Close

    Previous reports have described that long-term combination exercise training improves cognitive functions in healthy elderly people. This study investigates the effects of 4 weeks of short-term combination exercise training on various cognitive functions of elderly people. We conducted a single-blinded randomized controlled trial with two parallel groups. Sixty-four healthy older adults were assigned randomly to a combination exercise training group or a waiting list control group. Participants in the combination exercise training group participated in the combination exercise training (aerobic, strength, and stretching exercise trainings) 3 days per week during 4 weeks (12 workouts total). The waiting list control group did not participate in the combination exercise training. Measures of the cognitive functions (executive functions, episodic memory, working memory, reading ability, attention, and processing speed) were conducted before and after training. Results showed that the combination exercise training improved executive functions, episodic memory, and processing speed compared to those attributes of the waiting list control group. This report was the first of a study demonstrating the beneficial effects of short-term combination exercise training on diverse cognitive functions of elderly people. Our study provides important evidence of the short-term combination exercise's effectiveness.

  283. Resilience after 3/11: structural brain changes 1 year after the Japanese earthquake. Peer-reviewed

    Sekiguchi A, Kotozaki Y, Sugiura M, Nouchi R, Takeuchi H, Hanawa S, Nakagawa S, Miyauchi CM, Araki T, Sakuma A, Taki Y, Kawashima R

    Molecular psychiatry　20　(5)　552-554　2014/04

    DOI： 10.1038/mp.2014.28 　

    ISSN： 1359-4184

    eISSN： 1476-5578

  284. Association between gray matter volume in the caudate nucleus and financial extravagance: findings from voxel-based morphometry. International-journal Peer-reviewed

    Ryoichi Yokoyama, Takayuki Nozawa, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Mayu Hanihara, Yuko Sassa, Ryuta Kawashima

    Neuroscience letters　563　28-32　2014/03/20

    DOI： 10.1016/j.neulet.2014.01.026 　

    ISSN： 0304-3940 1872-7972

    More details Close

    Consumer behavior differs among individuals; one such common individual difference is financial extravagance. Recent research suggests that the activation of the caudate nucleus plays an important role in consumer behavior. However, to the best of our knowledge, no study has investigated the specific relationship between the caudate nucleus and consumer financial extravagance. Therefore, in this study, we investigated the association between individual differences in financial extravagance and regional gray matter volume in the caudate nucleus by using voxel-based morphometry (VBM). We recruited 776 healthy, right-handed individuals (432 men and 344 women; mean age=20.7 ± 1.8) and used voxel-based morphometry and a financial extravagance questionnaire to determine the association between financial extravagance and gray matter structure in the caudate nucleus. Our measure of financial extravagance was based on the novelty seeking subscales of the Japanese version of the Temperament and Character Inventory. A multiple regression analysis including financial extravagance, age, sex, Raven's Advanced Progressive Matrix score, total intracranial volume, and novelty seeking subscales was conducted to examine what variables were related to regional gray matter volume in the region of interest within the caudate nucleus. A significant positive correlation was found between the obtained financial extravagance score and regional gray matter volume in the caudate nucleus. We found that structural variations in the caudate nucleus contributed to individual differences in financial extravagance. This finding may provide a new neuroscientific approach to understanding individual characteristics of consumers.

  285. Neural differences in processing of case particles in Japanese: an fMRI study. Peer-reviewed

    Hashimoto Y, Yokoyama S, Kawashima R

    Brain and behavior　4　180-186　2014/03

    Publisher: 2

    DOI： 10.1002/brb3.201 　

  286. Riding a Motorcycle Affects Cognitive Functions of Healthy Adults:- A preliminary controlled study -

    Kawashima Ryuta, Nouchi Rui, Matsumoto Taisuke, Tanimoto Yasunori

    International Journal of Automotive Engineering　5　(2)　73-76　2014

    Publisher: Society of Automotive Engineers of Japan, INC

    DOI： 10.20485/jsaeijae.5.2_73 　

    ISSN： 2185-0984

    More details Close

    We investigated whether riding a motorcycle in daily life has beneficial effects on the cognitive functions of healthy subjects. Twenty-two healthy right-handed men, who had a significant break from riding, participated in this study. They were randomly assigned to either the intervention or control group. The intervention group was asked to ride a motorcycle in their daily life for two months. The intervention group showed improvement of their visuospatial cognition compared with the control group. Results of this study indicate that riding a motorcycle in daily life could have beneficial effects in returning riders.

  287. Remembering with gains and losses: Effects of monetary reward and punishment on successful encoding activation of source memories

    Yayoi Shigemune, Takashi Tsukiura, Toshimune Kambara, Ryuta Kawashima

    Cerebral Cortex　24　(5)　1319-1331　2014

    DOI： 10.1093/cercor/bhs415 　

    ISSN： 1047-3211

    eISSN： 1460-2199

  288. Positive auditory cortical responses in patients with absent brainstem response Peer-reviewed

    Tetsuaki Kawase, Akitake Kanno, Yusuke Takata, Nobukazu Nakasato, Ryuta Kawashima, Toshimitsu Kobayashi

    CLINICAL NEUROPHYSIOLOGY　125　(1)　148-153　2014/01

    DOI： 10.1016/j.clinph.2013.06.184 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  289. Creativity measured by divergent thinking is associated with two axes of autistic characteristics International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M. Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Yuko Sassa, Ryuta Kawashima

    Frontiers in Psychology　5　(AUG)　921-921　2014

    DOI： 10.3389/fpsyg.2014.00921 　

    eISSN： 1664-1078

  290. Optogenetic patterning of whisker-barrel cortical system in transgenic rat expressing channelrhodopsin-2. International-journal Peer-reviewed

    Tatsuya Honjoh, Zhi-Gang Ji, Yukinobu Yokoyama, Akira Sumiyoshi, Yuma Shibuya, Yoshiya Matsuzaka, Ryuta Kawashima, Hajime Mushiake, Toru Ishizuka, Hiromu Yawo

    PloS one　9　(4)　e93706　2014

    DOI： 10.1371/journal.pone.0093706 　

    More details Close

    The rodent whisker-barrel system has been an ideal model for studying somatosensory representations in the cortex. However, it remains a challenge to experimentally stimulate whiskers with a given pattern under spatiotemporal precision. Recently the optogenetic manipulation of neuronal activity has made possible the analysis of the neuronal network with precise spatiotemporal resolution. Here we identified the selective expression of channelrhodopsin-2 (ChR2), an algal light-driven cation channel, in the large mechanoreceptive neurons in the trigeminal ganglion (TG) as well as their peripheral nerve endings innervating the whisker follicles of a transgenic rat. The spatiotemporal pattern of whisker irradiation thus produced a barrel-cortical response with a specific spatiotemporal pattern as evidenced by electrophysiological and functional MRI (fMRI) studies. Our methods of generating an optogenetic tactile pattern (OTP) can be expected to facilitate studies on how the spatiotemporal pattern of touch is represented in the somatosensory cortex, as Hubel and Wiesel did in the visual cortex.

  291. Age-related differences in prefrontal, parietal, and hippocampal activations during correct rejections of faces Invited Peer-reviewed

    Takashi Tsukiura, Yayoi Shigemune, Rui Nouchi, Toshimune Kambara, Ryuta Kawashima

    JAPANESE PSYCHOLOGICAL RESEARCH　56　(1)　2-14　2014/01

    DOI： 10.1111/jpr.12017 　

    ISSN： 0021-5368

    eISSN： 1468-5884

  292. Neural substrates of politeness during utterance production

    Akimoto Yoritaka, Sugiura Motoaki, Suzuki MIzue, Nozawa Takayuki, Hanawa Sugiko, Miyazawa Shiho, Kawashima Ryuta

    Proceedings of the Japanese Society for Cognitive Psychology　2014　(0)　94-94　2014

    Publisher: 日本認知心理学会

    DOI： 10.14875/cogpsy.2014.0_94 　

    More details Close

    我々は、円滑な人間関係を確立・維持するために言語的配慮（ポライトネス）を行っている。ポライトネスには、他者に邪魔されたくないという欲求に配慮する方略（ネガティブポライトネス）と、他者に認められたいという欲求に配慮する方略（ポジティブポライトネス）の2方向の方略がある。本研究では、fMRIを用いて発話産出におけるポライトネスの神経基盤を検討した。実験参加者は、MRIの中で、日常場面で些細な失敗をした架空の友人に対して、 (1)ポジティブポライトネスを用いる、(2)ネガティブポライトネスを用いる条件、(3)ポライトネスを用いない、のいずれかの条件で発話の産出を行った。その結果、ネガティブポライトネス特異的な領域として左眼窩前頭皮質前部および右眼窩前頭皮質後部を、ネガティブポライトネス特異的な領域として右扁桃体を、両方のポライトネスに共通して関与する領域として右外側眼窩前頭皮質後部を同定した。

  293. Advancement and limitation of SQUID-based MEG

    Akitake Kanno, Nobukazu Nakasato, Nobukazu Nakasato, Ryuta Kawashima

    Transactions of Japanese Society for Medical and Biological Engineering　52　OS-26　2014/01/01

    DOI： 10.11239/jsmbe.52.OS-26 　

    ISSN： 1881-4379

    eISSN： 1347-443X

  294. Associations among imaging measures (2): the association between gray matter concentration and task-induced activation changes. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Yuko Sassa, Atsushi Sekuguchi, Yuka Kotozaki, Seishu Nakagawa, Tomomi Nagase, Carlos Makoto Miyauchi, Ryuta Kawashima

    Human brain mapping　35　(1)　185-98　2014/01

    DOI： 10.1002/hbm.22167 　

    ISSN： 1065-9471

    More details Close

    The association between functional activation and gray matter (GM) structure has been revealed in clinical studies and studies of aging involving a small number of subjects. The purpose of this study was to investigate the association between functional activation maps and GM structures in young adults who do not show apparent GM atrophy and to investigate in detail the nature of this association using a large number of subjects. We used voxel-by-voxel regression analyses to investigate voxel-by-voxel associations between GM concentration (GMC) and contrast estimate images of brain activity during n-back working memory tasks. Associations were assessed for each voxel after regressing out the effects of age, sex, and mean signal intensity during functional magnetic resonance imaging scanning at each voxel using data from 248 normal, right-handed, young adult subjects. In our study, the concept of "the greater the GMC, the greater the task-related activation increase/task-related activation decrease (or the greater the task-related activation change from baseline)" was true for a wide range of activated and deactivated areas. However, in some minor regions, the other pattern of "the greater the GMC, the smaller the task-related activation increase" was observed. The first pattern is often observed at the borders of GM structures. These findings may have to be taken into consideration when group/individual differences in functional activation are investigated.

  295. Ongoing activity in temporally coherent networks predicts intra-subject fluctuation of response time to sporadic executive control demands. International-journal Peer-reviewed

    Takayuki Nozawa, Motoaki Sugiura, Ryoichi Yokoyama, Mizuki Ihara, Yuka Kotozaki, Carlos Makoto Miyauchi, Akitake Kanno, Ryuta Kawashima

    PloS one　9　(6)　e99166　2014

    DOI： 10.1371/journal.pone.0099166 　

    More details Close

    Can ongoing fMRI BOLD signals predict fluctuations in swiftness of a person's response to sporadic cognitive demands? This is an important issue because it clarifies whether intrinsic brain dynamics, for which spatio-temporal patterns are expressed as temporally coherent networks (TCNs), have effects not only on sensory or motor processes, but also on cognitive processes. Predictivity has been affirmed, although to a limited extent. Expecting a predictive effect on executive performance for a wider range of TCNs constituting the cingulo-opercular, fronto-parietal, and default mode networks, we conducted an fMRI study using a version of the color-word Stroop task that was specifically designed to put a higher load on executive control, with the aim of making its fluctuations more detectable. We explored the relationships between the fluctuations in ongoing pre-trial activity in TCNs and the task response time (RT). The results revealed the existence of TCNs in which fluctuations in activity several seconds before the onset of the trial predicted RT fluctuations for the subsequent trial. These TCNs were distributed in the cingulo-opercular and fronto-parietal networks, as well as in perceptual and motor networks. Our results suggest that intrinsic brain dynamics in these networks constitute "cognitive readiness," which plays an active role especially in situations where information for anticipatory attention control is unavailable. Fluctuations in these networks lead to fluctuations in executive control performance.

  296. Spinal fMRI of interoceptive attention/awareness in experts and novices. International-journal Peer-reviewed

    Keyvan Kashkouli Nejad, Motoaki Sugiura, Benjamin Thyreau, Takayuki Nozawa, Yuka Kotozaki, Yoshihito Furusawa, Kozo Nishino, Toshohiro Nukiwa, Ryuta Kawashima

    Neural plasticity　2014　679509-679509　2014

    DOI： 10.1155/2014/679509 　

    ISSN： 2090-5904

    More details Close

    Many disciplines/traditions that promote interoceptive (inner sensation of body parts) attention/awareness (IAA) train practitioners to both attend to and be aware of interoceptive sensory experiences in body parts. The effect of such practices has been investigated in previous imaging studies but limited to cerebral neural activity. Here, for the first time, we studied the impact of these practices on the spinal neural activity of experts and novices. We also attempted to clarify the effect of constant and deep breathing, a paradigm utilized in concentration practices to avoid mind wandering, on IAA-related spinal neural activity. Subjects performed IAA tasks with and without a deep and constant breathing pattern in two sessions. Results showed that neural activity in the spinal segment innervating the attended-to body area increased in experts (P = 0.04) when they performed IAA and that this increase was significantly larger for experts versus novices in each of the sessions (P = 0.024). The significant effects of IAA and expertise on spinal neural activity are consistent with and elaborate on previous reports showing similar effects on cerebral neural activity. As the spinal cord directly innervates body parts, the results might indicate that IAA has an instantaneous (possibly beneficial) effect on the physical body after extended training.

  297. Working memory training improves emotional states of healthy individuals. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

    Frontiers in systems neuroscience　8　200-200　2014

    DOI： 10.3389/fnsys.2014.00200 　

    More details Close

    Working memory (WM) capacity is associated with various emotional aspects, including states of depression and stress, reactions to emotional stimuli, and regulatory behaviors. We have previously investigated the effects of WM training (WMT) on cognitive functions and brain structures. However, the effects of WMT on emotional states and related neural mechanisms among healthy young adults remain unknown. In the present study, we investigated these effects in young adults who underwent WMT or received no intervention for 4 weeks. Before and after the intervention, subjects completed self-report questionnaires related to their emotional states and underwent scanning sessions in which brain activities related to negative emotions were measured. Compared with controls, subjects who underwent WMT showed reduced anger, fatigue, and depression. Furthermore, WMT reduced activity in the left posterior insula during tasks evoking negative emotion, which was related to anger. It also reduced activity in the left frontoparietal area. These findings show that WMT can reduce negative mood and provide new insight into the clinical applications of WMT, at least among subjects with preclinical-level conditions.

  298. Neuronal substrates characterizing two stages in visual object recognition International-journal Peer-reviewed

    Tomoya Taminato, Naoki Miura, Motoaki Sugiura, Ryuta Kawashima

    Neuroscience Research　89　61-68　2014/01/01

    DOI： 10.1016/j.neures.2014.09.001 　

    ISSN： 0168-0102

  299. Animacy or case marker order?: priority information for online sentence comprehension in a head-final language. Peer-reviewed

    Yokoyama S, Takahashi K, Kawashima R

    PloS one　9　e93109　2014

    Publisher: 3

    DOI： 10.1371/journal.pone.0093109 　

  300. Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Hiroshi Hashizume, Seishu Nakagawa, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Brain structure & function　219　(1)　71-83　2014/01

    Publisher: 1

    DOI： 10.1007/s00429-012-0485-3 　

    ISSN： 1863-2661 1863-2653

    More details Close

    Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-based morphometry and a questionnaire (achievement motivation scale) to measure individual achievement motivation and investigated the association between rGM density (rGMD) and achievement motivation [self-fulfillment achievement motivation (SFAM) and competitive achievement motivation (CAM) across the brain in healthy young adults (age 21.0 ± 1.8 years, men (n = 94), women (n = 91)]. SFAM and rGMD significantly and negatively correlated in the orbitofrontal cortex (OFC). CAM and rGMD significantly and positively correlated in the right putamen, insula, and precuneus. These results suggest that the brain areas that play central roles in externally modulated motivation (OFC and putamen) also contribute to SFAM and CAM, respectively, but in different ways. Furthermore, the brain areas in which rGMD correlated with CAM are related to cognitive processes associated with distressing emotions and social cognition, and these cognitive processes may characterize CAM.

  301. White matter microstructural changes as vulnerability factors and acquired signs of post-earthquake distress. International-journal Peer-reviewed

    Atsushi Sekiguchi, Motoaki Sugiura, Yasuyuki Taki, Yuka Kotozaki, Rui Nouchi, Hikaru Takeuchi, Tsuyoshi Araki, Sugiko Hanawa, Seishu Nakagawa, Carlos Makoto Miyauchi, Atsushi Sakuma, Ryuta Kawashima

    PloS one　9　(1)　e83967　2014

    Publisher: 1

    DOI： 10.1371/journal.pone.0083967 　

    ISSN： 1932-6203

    More details Close

    Many survivors of severe disasters need psychological support, even those not suffering post-traumatic stress disorder (PTSD). The critical issue in understanding the psychological response after experiencing severe disasters is to distinguish neurological microstructural underpinnings as vulnerability factors from signs of emotional distress acquired soon after the stressful life event. We collected diffusion-tensor magnetic resonance imaging (DTI) data from a group of healthy adolescents before the Great East Japan Earthquake and re-examined the DTIs and anxiety levels of 30 non-PTSD subjects from this group 3-4 months after the earthquake using voxel-based analyses in a longitudinal DTI study before and after the earthquake. We found that the state anxiety level after the earthquake was negatively associated with fractional anisotropy (FA) in the right anterior cingulum (Cg) before the earthquake (r = -0.61, voxel level p<0.0025, cluster level p<0.05 corrected), and positively associated with increased FA changes from before to after the earthquake in the left anterior Cg (r = 0.70, voxel level p<0.0025, cluster level p<0.05 corrected) and uncinate fasciculus (Uf) (r = 0.65, voxel level p<0.0025, cluster level p<0.05 corrected). The results demonstrated that lower FA in the right anterior Cg was a vulnerability factor and increased FA in the left anterior Cg and Uf was an acquired sign of state anxiety after the earthquake. We postulate that subjects with dysfunctions in processing fear and anxiety before the disaster were likely to have higher anxiety levels requiring frequent emotional regulation after the disaster. These findings provide new evidence of psychophysiological responses at the neural network level soon after a stressful life event and might contribute to the development of effective methods to prevent PTSD.

  302. Long-term effects of postearthquake distress on brain microstructural changes. International-journal Peer-reviewed

    Atsushi Sekiguchi, Yuka Kotozaki, Motoaki Sugiura, Rui Nouchi, Hikaru Takeuchi, Sugiko Hanawa, Seishu Nakagawa, Carlos Makoto Miyauchi, Tsuyoshi Araki, Atsushi Sakuma, Yasuyuki Taki, Ryuta Kawashima

    BioMed research international　2014　(Neuroscience)　180468-180468　2014

    DOI： 10.1155/2014/180468 　

    ISSN： 2314-6133 2314-6141

    More details Close

    Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability factor and increased WMI in the left anterior Cg and uncinate fasciculus (Uf) after the earthquake was an acquired sign of postearthquake distress. However, the long-term effects on WMI remained unclear. Here, we examined the 1-year WMI changes in 25 subjects to clarify long-term effects on the WMI. We found differential FAs in the right anterior Cg, bilateral Uf, left superior longitudinal fasciculus (SLF), and left thalamus, suggesting that synaptic enhancement and shrinkage were long-term effects. Additionally, the correlation between psychological measures related to postearthquake distress and the degree of WMI alternation in the right anterior Cg and the left Uf led us to speculate that temporal WMI changes in some subjects with emotional distress occurred soon after the disaster. We hypothesized that dynamic WMI changes predict a better prognosis, whereas persistently lower WMI is a marker of cognitive dysfunction, implying the development of anxiety disorders.

  303. Regional gray matter volume is associated with empathizing and systemizing in young adults. Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

    PloS one　9　(1)　e84782　2014/01

    Publisher: 1

    DOI： 10.1371/journal.pone.0084782 　

    ISSN： 1932-6203

  304. A longitudinal study of the relationship between personality traits and the annual rate of volume changes in regional gray matter in healthy adults. Peer-reviewed

    Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, Fukuda H

    Human brain mapping　34　(12)　3347-3353　2013/12

    DOI： 10.1002/hbm.22145 　

    ISSN： 1065-9471

  305. Resting state functional connectivity associated with trait emotional intelligence. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

    NeuroImage　83　318-28　2013/12

    DOI： 10.1016/j.neuroimage.2013.06.044 　

    ISSN： 1095-9572 1053-8119

    More details Close

    Previous neuroimaging studies have suggested that trait emotional intelligence (TEI) is associated with components of the neural network involved in social cognition (SCN) and somatic marker circuitry (SMC). Our study is the first to investigate the association of TEI with resting-state functional connectivity (RSFC) between the key nodes of SCN and SMC [medial prefromtal cortex (mPFC) and bilateral anterior insula (AI), respectively] and other brain regions. We found that (a) the intrapersonal factor of TEI was negatively correlated with RSFC between mPFC and the anterior part of the right dorsolateral prefrontal cortex (DLPFC), (b) the TEI interpersonal factor score was positively correlated with RSFC between mPFC and the lingual gyrus, and (c) total TEI was positively correlated with RSFC between mPFC and the precuneus as well as (d) between the left AI and the middle part of the right DLPFC. Taken together with previous study findings, our findings can be comprehensively understood as neural mechanisms of SCN and SMC components are associated with TEI. In particular, the fluent interaction between SCN's two key nodes (mPFC and precuneus/PCC) [as well as between DMN's two key nodes] is suggested to be crucial for total TEI. Our study also indicated that (a) a clear functional separation between the two key nodes of the two major intrinsic networks, DMN and the task-positive network (mPFC and DLPFC), is important for higher intrapersonal TEI, (b) brain interactions involving vision-related areas (lingual gyrus) and the key node of SCN (mPFC) are important for interpersonal TEI, and (c) control of DLPFC over the key node of SMC (AI) is important for total TEI.

  306. Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects. Peer-reviewed

    Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kakizaki M, Tsuji I, Kawashima R, Fukuda H

    Human brain mapping　34　(10)　2418-2424　2013/10

    DOI： 10.1002/hbm.22073 　

    ISSN： 1065-9471

  307. 健常成人における性格と局所灰白質体積減少速度との相関

    瀧 靖之, Thyreay Thyreau, 木之村 重男, 佐藤 和則, 後藤 了以, 川島 隆太, 福田 寛

    日本老年医学会雑誌　50　(5)　682-682　2013/09

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  308. Altered brain activity in patients with anorexia nervosa during decision making: an fMRI study Peer-reviewed

    Sato Y, Aizawa E, Sekiguchi A, Kotozaki Y, Sugiura M, Taki Y, Hashizume H, Shoji T, Endo Y, Kochiyama T, Kawashima R, Fukudo S

    Psychotherapy and Psychosomatics　82　(S1)　98-98　2013/09

  309. A longitudinal study of age- and gender-related annual rate of volume changes in regional gray matter in healthy adults Peer-reviewed

    Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, Fukuda H

    Human Brain Mapping　34　(9)　2292-2301　2013/09

    DOI： 10.1002/hbm.22067 　

    ISSN： 1065-9471

  310. Cross-linguistic influence of first language writing systems on brain responses to second language word reading in late bilinguals. Peer-reviewed

    Yokoyama S, Kim J, Uchida S, Miyamoto T, Yoshimoto K, Kawashima R

    Brain and behavior　3　525-531　2013/09

    Publisher: 5

    DOI： 10.1002/brb3.153 　

  311. Effects of working memory training on functional connectivity and cerebral blood flow during rest. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Calros M Miyauchi, Yuko Sassa, Ryuta Kawashima

    Cortex; a journal devoted to the study of the nervous system and behavior　49　(8)　2106-25　2013/09

    Publisher: 8

    DOI： 10.1016/j.cortex.2012.09.007 　

    ISSN： 1973-8102 0010-9452

    More details Close

    Working memory (WM) training (WMT) alters the task-related brain activity and structure of the external attention system (EAS). We investigated whether WMT also alters resting-state brain mechanisms, which are assumed to reflect intrinsic brain activity and connectivity. Our study subjects were subjected to a 4-week WMT program and brain scans before and after the intervention for determining changes of functional connectivity and regional cerebral blood flow during rest (resting-FC/resting-rCBF). Compared with no-intervention, WMT (a) increased resting-FC between the medial prefrontal cortex (mPFC) and precuneus, which are key nodes of the default mode network (DMN), (b) decreased resting-FC between mPFC and the right posterior parietal cortex/right lateral prefrontal cortex (LPFC), which are key nodes of the EAS, and (c) increased resting-rCBF in the right LPFC. However, the training-related decreases in resting-FC between the key DMN node and the nodes of EAS were only observed when the whole brain signal was regressed out in individual analyses, and these changes were not observed when the whole brain signal was not regressed out in individual analyses. Further analyses indicated that these differences may be mediated by a weak but a widespread increase in resting-FC between the nodes of EAS and activity of multiple bilateral areas across the brain. These results showed that WMT induces plasticity in neural mechanisms involving DMN and the EAS during rest and indicated that intrinsic brain activity and connectivity can be affected by cognitive training.

  312. Interactions between the heart and the brain in heart failure patients assessed by magnetic resonance imaging - interim results from Brain assessment and investigation in Heart Failure Trial (B-HeFT) Peer-reviewed

    H. Suzuki, Y. Matsumoto, H. Ota, Y. Kotozaki, J. Takahashi, K. Ito, Y. Fukumoto, R. Kawashima, Y. Taki, H. Shimokawa

    European Heart Journal　34　(suppl 1)　P2732-P2732　2013/08/02

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/eurheartj/eht309.p2732 　

    ISSN： 0195-668X

    eISSN： 1522-9645

  313. Voxel-based morphometry and histological analysis for evaluating hippocampal damage in a rat model of cardiopulmonary resuscitation. International-journal Peer-reviewed

    Suzuki H, Sumiyoshi A, Taki Y, Matsumoto Y, Fukumoto Y, Kawashima R, Shimokawa H

    NeuroImage　77　215-221　2013/08

    DOI： 10.1016/j.neuroimage.2013.03.042 　

    ISSN： 1053-8119

    More details Close

    Cardiac arrest and subsequent cardiopulmonary resuscitation (CPR) induce hippocampal damage, which has been identified using histological analysis of post-mortem brains. Voxel-based morphometry (VBM), an in-vivo assessment of regional differences in the concentration or volume of a particular tissue such as gray matter, has revealed CPR-induced decreases in gray matter in the hippocampus, where histopathological findings were observed. However, the potential link between the changes in gray matter detected by VBM and hippocampal damage has not been investigated directly. In this study, we compared results obtained using VBM directly to results from histological analyses in the same CPR rat brains, which exhibited neuronal loss and microglial invasion in the CA1 region of the hippocampus (CA1). T2-weighted images were obtained and preprocessed for VBM to produce gray matter concentration (GMC) maps in rats with asphyxia-induced cardiac arrest and CPR and sham-operated controls (n=12 each). Brains were fixed, and the number of neurons and microglia in CA1 were counted. VBM revealed a significant decrease in GMC in CPR rats compared to sham-operated controls. The CPR-induced decrease in GMC was localized to CA1, which is the same brain region where neuronal loss and microglial invasion were noted in response to CPR. GMC values were positively correlated with the number of neurons and tended to be negatively correlated with the number of microglia in CA1 of CPR rats. In conclusion, these results indicate that VBM-detected alterations in gray matter can be used as a surrogate marker for hippocampal damage following CPR.

  314. Linear and curvilinear correlations of brain white matter volume, fractional anisotropy, and mean diffusivity with age using voxel-based and region-of-interest analyses in 246 healthy children. International-journal Peer-reviewed

    Yasuyuki Taki, Benjamin Thyreau, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

    Human brain mapping　34　(8)　1842-56　2013/08

    DOI： 10.1002/hbm.22027 　

    ISSN： 1065-9471

    More details Close

    In this study, we examined linear and curvilinear correlations of fractional anisotropy (FA), mean diffusivity (MD), and white matter volume with age by using brain structural and diffusion-tensor magnetic resonance imaging (MRI) in a large number of healthy children and voxel-based morphometry (VBM) and region-of-interest (ROI) analyses. We collected data by brain structural MRI in 246 healthy children, aged 5-18 years. FA and MD images were normalized using the normalization parameter of the corresponding structural MRI. Next, we analyzed the correlations between FA and age and between MD and age by estimating linear and logarithmic functions. We also analyzed the correlation between white matter volume and age by linear, quadratic, and cubic functions. Correlations between FA and age and between MD and age showed exponential trajectories in most ROIs in boys and girls, except for several fibers, such as the corpus callosum connecting the bilateral rectal gyri in boys. The correlation between white matter volume and age showed significant positive linear trajectories in most ROIs in boys and girls, except for a few fibers, such as the bilateral uncinate fasciculus. Additionally, maturational rates differed among major fibers, and in girls, the left superior longitudinal fasciculus, which connects the frontal and temporal lobes, showed a slower rate of maturation than other fibers. Our results may help to clarify the mechanisms of normal brain maturation from the viewpoint of brain white matter.

  315. Linear and curvilinear correlations of brain gray matter volume and density with age using voxel-based morphometry with the Akaike information criterion in 291 healthy children. International-journal Peer-reviewed

    Yasuyuki Taki, Hiroshi Hashizume, Benjamin Thyreau, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

    Human brain mapping　34　(8)　1857-71　2013/08

    DOI： 10.1002/hbm.22033 　

    ISSN： 1065-9471

    More details Close

    We examined linear and curvilinear correlations of gray matter volume and density in cortical and subcortical gray matter with age using magnetic resonance images (MRI) in a large number of healthy children. We applied voxel-based morphometry (VBM) and region-of-interest (ROI) analyses with the Akaike information criterion (AIC), which was used to determine the best-fit model by selecting which predictor terms should be included. We collected data on brain structural MRI in 291 healthy children aged 5-18 years. Structural MRI data were segmented and normalized using a custom template by applying the diffeomorphic anatomical registration using exponentiated lie algebra (DARTEL) procedure. Next, we analyzed the correlations of gray matter volume and density with age in VBM with AIC by estimating linear, quadratic, and cubic polynomial functions. Several regions such as the prefrontal cortex, the precentral gyrus, and cerebellum showed significant linear or curvilinear correlations between gray matter volume and age on an increasing trajectory, and between gray matter density and age on a decreasing trajectory in VBM and ROI analyses with AIC. Because the trajectory of gray matter volume and density with age suggests the progress of brain maturation, our results may contribute to clarifying brain maturation in healthy children from the viewpoint of brain structure.

  316. White matter structures associated with empathizing and systemizing in young adults. International-journal Peer-reviewed

    Takeuchi H, Taki Y, Thyreau B, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R

    NeuroImage　77　222-236　2013/08

    DOI： 10.1016/j.neuroimage.2013.04.004 　

    ISSN： 1095-9572 1053-8119

    More details Close

    Empathizing is defined as the drive to identify the mental states of others in order to predict their behavior and respond with an appropriate emotion. Systemizing is defined as the drive to analyze a system in terms of the rules that govern it to predict its behavior. We undertook voxel-by-voxel investigations of regional white matter volume (rWMV) and fractional anisotropy (FA) of diffusion tensor imaging to discover the WM structural correlates of empathizing, systemizing, and their difference (D score: systemizing-empathizing). Whole brain analyses of covariance revealed that across both sexes, the D score was negatively correlated with rWMV in the WM area in the bilateral temporal lobe, near the right inferior frontal gyrus, near the ventral medial prefrontal cortex, and near the posterior cingulate cortex and positively correlated with FA in an area involving the superior longitudinal fasciculus. Post-hoc analyses revealed that these associations were generally formed by both the correlation between WM structures and empathizing as well as the opposite correlation between WM structures and systemizing. A significant effect of interaction between sex and the D score on rWMV, which was mainly observed because of a positive correlation between rWMV and empathizing in females and a negative correlation between rWMV and systemizing in females, was found in an area close to the right inferior parietal lobule and temporoparietal junction. Our results suggest that WM structures involving the default mode network and the mirror neuron system support empathizing, and that a WM structure relating to the external attention system supports systemizing. Further, our results revealed an overlap between positive/negative WM structural correlates of empathizing and negative/positive WM structural correlates of systemizing despite little correlation between empathizing and systemizing, which supports the previously held idea that there is a trade-off between empathizing and systemizing in the brain.

  317. Brain structures associated with executive functions during everyday events in a non-clinical sample. Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

    Brain structure & function　218　(4)　1017-1032　2013/07

    Publisher: 4

    DOI： 10.1007/s00429-012-0444-z 　

    ISSN： 1863-2661 1863-2653

  318. Insular and hippocampal contributions to remembering people with an impression of bad personality

    Takashi Tsukiura, Yayoi Shigemune, Rui Nouchi, Toshimune Kambara, Ryuta Kawashima

    Social Cognitive and Affective Neuroscience　8　(5)　515-522　2013/06

    DOI： 10.1093/scan/nss025 　

    ISSN： 1749-5016

    eISSN： 1749-5024

  319. Correlation between pulmonary function and brain volume in healthy elderly subjects. International-journal Peer-reviewed

    Yasuyuki Taki, Shigeo Kinomura, Satoru Ebihara, Benjamin Thyreau, Kazunori Sato, Ryoi Goto, Masako Kakizaki, Ichiro Tsuji, Ryuta Kawashima, Hiroshi Fukuda

    Neuroradiology　55　(6)　689-95　2013/06

    DOI： 10.1007/s00234-013-1157-6 　

    More details Close

    INTRODUCTION: Cigarette smoking decreases brain regional gray matter volume and is related to chronic obstructive lung disease (COPD). COPD leads to decreased pulmonary function, which is represented by forced expiratory volume in one second percentage (FEV1.0 %); however, it is unclear if decreased pulmonary function is directly related to brain gray matter volume decline. Because there is a link between COPD and cognitive decline, revealing a direct relationship between pulmonary function and brain structure is important to better understand how pulmonary function affects brain structure and cognitive function. Therefore, the purpose of this study was to analyze whether there were significant correlations between FEV1.0 % and brain regional gray and white matter volumes using brain magnetic resonance (MR) image data from 109 community-dwelling healthy elderly individuals. METHODS: Brain MR images were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. RESULTS: We found a significant positive correlation between the regional white matter volume of the cerebellum and FEV1.0 % after adjusting for age, sex, and intracranial volume. CONCLUSION: Our results suggest that elderly individuals who have a lower FEV1.0 % have decreased regional white matter volume in the cerebellum. Therefore, preventing decreased pulmonary function is important for cerebellar white matter volume in the healthy elderly population.

  320. 加害行為に関する脳内表象の復号化：fMRI研究

    宮内誠カルロス, 杉浦元亮, 蓬田幸人, 秋元頼孝, 月浦崇, 川島隆太

    Proceedings of the 27th Annual Conference of the Japanese Society for Artificial Intelligenc　1　(1)　1-4　2013/06/01

    Publisher: Japanese Society for Artificial Intelligence

  321. Is the phonological deficit in developmental dyslexia related to impaired phonological representations and to universal phonological grammar? Peer-reviewed

    Maïonchi-Pino N, Taki Y, Yokoyama S, Magnan A, Takahashi K, Hashizume H, Écalle J, Kawashima R

    Journal of experimental child psychology　115　53-73　2013/05

    Publisher: 1

    DOI： 10.1016/j.jecp.2012.10.006 　

    ISSN： 0022-0965

  322. Activity in the primary somatosensory cortex induced by reflexological stimulation is unaffected by pseudo-information: a functional magnetic resonance imaging study. Peer-reviewed

    Miura N, Akitsuki Y, Sekiguchi A, Kawashima R

    BMC complementary and alternative medicine　13　114　2013/05

    DOI： 10.1186/1472-6882-13-114 　

    ISSN： 1472-6882

  323. A longitudinal study of structural brain network changes with normal aging Peer-reviewed

    Kai Wu, Yasuyuki Taki, Kazunori Sato, Haochen Qi, Ryuta Kawashima, Hiroshi Fukuda

    Frontiers in Human Neuroscience　(2013)　2013/04/03

    Publisher: Frontiers Media S. A.

    DOI： 10.3389/fnhum.2013.00113 　

    ISSN： 1662-5161

  324. RESILIENCE AFTER 3/11: BRAIN STRUCTURAL CHANGES ONE-YEAR AFTER THE GREAT EAST JAPAN EARTHQUAKE Peer-reviewed

    Sekiguchi Atsushi, Sugiura Motoaki, Kotozaki Yuka, Araki Tsuyoshi, Hanawa Sugiko, Nakagawa Seishu, Miyauchi Carlos M, Sakuma Atsushi, Taki Yasuyuki, Kawashima Ryuta

    PSYCHOSOMATIC MEDICINE　75　(3)　A69-A70　2013/04

    ISSN： 0033-3174

  325. Anatomical correlates of self-handicapping tendency. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Yuko Sassa, Ryuta Kawashima

    Cortex; a journal devoted to the study of the nervous system and behavior　49　(4)　1148-54　2013/04

    Publisher: 4

    DOI： 10.1016/j.cortex.2013.01.014 　

    ISSN： 1973-8102 0010-9452

    More details Close

    Self-handicaps are obstacles created (or claimed) by individuals in anticipation of failure. Despite the vast amount of psychological research on self-handicapping tendency, the neural mechanisms underlying individual differences in self-handicapping tendency in young and healthy subjects are unknown. We used voxel-based morphometry (VBM) and a questionnaire to measure individual self-handicapping tendency, and we investigated the association between regional gray matter volume (rGMV) and self-handicapping tendency across the brain in healthy young adult (mean age, 21.3 years; standard deviation - SD = 1.9) men (n = 94) and women (n = 91). We discovered that higher individual self-handicapping tendency was associated with larger rGMV in the subgenual cingulate gyrus (sgCG). A wide range of previous studies showed (a) the opposite pattern is seen in the association between rGMV in the sgCG and depression and (b) this area is active when negative emotions are suppressed. The present results suggest that the sgCG is also involved in self-handicapping, which is a behavior thought to be engaged in the protection of self-esteem.

  326. Spatiotemporal Dynamics of High-Gamma Activities during a 3-Stimulus Visual Oddball Task Peer-reviewed

    Akimoto Yoritaka, Kanno Akitake, Kambara Toshimune, Nozawa Takayuki, Sugiura Motoaki, Okumura Eiichi, Kawashima Ryuta

    PLOS ONE　8　(3)　2013/03/21

    DOI： 10.1371/journal.pone.0059969 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  327. The relationship between luxury/necessity perception and the structure of desire Peer-reviewed

    Ryoichi Yokoyama, Takayuki Nozawa, Rui Nouchi, Motoaki Sugiura, Ryuta Kawashima

    Human Science & Technology　(10)　58-61　2013/03

  328. Neural correlates of adaptive social responses to real-life frustrating situations: a functional MRI study. Peer-reviewed

    Sekiguchi A, Sugiura M, Yokoyama S, Sassa Y, Horie K, Sato S, Kawashima R

    BMC neuroscience　14　29　2013/03

    DOI： 10.1186/1471-2202-14-29 　

    ISSN： 1471-2202

  329. Different brain activation under left and right ventricular stimulation: an fMRI study in anesthetized rats. International-journal

    Hideaki Suzuki, Akira Sumiyoshi, Ryuta Kawashima, Hiroaki Shimokawa

    PloS one　8　(2)　e56990　2013

    DOI： 10.1371/journal.pone.0056990 　

    More details Close

    BACKGROUND: Myocardial ischemia in the anterior wall of the left ventricule (LV) and in the inferior wall and/or right ventricle (RV) shows different manifestations that can be explained by the different innervations of cardiac afferent nerves. However, it remains unclear whether information from different areas of the heart, such as the LV and RV, are differently processed in the brain. In this study, we investigated the brain regions that process information from the LV or RV using cardiac electrical stimulation and functional magnetic resonance imaging (fMRI) in anesthetized rats because the combination of these two approaches cannot be used in humans. METHODOLOGY/PRINCIPAL FINDINGS: An electrical stimulation catheter was inserted into the LV or RV (n = 12 each). Brain fMRI scans were recorded during LV or RV stimulation (9 Hz and 0.3 ms width) over 10 blocks consisting of alternating periods of 2 mA for 30 sec followed by 0.2 mA for 60 sec. The validity of fMRI signals was confirmed by first and second-level analyses and temporal profiles. Increases in fMRI signals were observed in the anterior cingulate cortex and the right somatosensory cortex under LV stimulation. In contrast, RV stimulation activated the right somatosensory cortex, which was identified more anteriorly compared with LV stimulation but did not activate the anterior cingulate cortex. CONCLUSION/SIGNIFICANCE: This study provides the first evidence for differences in brain activation under LV and RV stimulation. These different brain processes may be associated with different clinical manifestations between anterior wall and inferoposterior wall and/or RV myocardial ischemia.

  330. Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection. International-journal Peer-reviewed

    Misaki Aizawa-Kohama, Toshiki Endo, Masaaki Kitada, Shohei Wakao, Akira Sumiyoshi, Dai Matsuse, Yasumasa Kuroda, Takahiro Morita, Jorge J Riera, Ryuta Kawashima, Teiji Tominaga, Mari Dezawa

    Cell transplantation　22　(9)　1613-25　2013

    DOI： 10.3727/096368912X658791 　

    ISSN： 0963-6897

    More details Close

    After severe spinal cord injury, spontaneous functional recovery is limited. Numerous studies have demonstrated cell transplantation as a reliable therapeutic approach. However, it remains unknown whether grafted neuronal cells could replace lost neurons and reconstruct neuronal networks in the injured spinal cord. To address this issue, we transplanted bone marrow stromal cell-derived neural progenitor cells (BM-NPCs) in a rat model of complete spinal cord transection 9 days after the injury. BM-NPCs were induced from bone marrow stromal cells (BMSCs) by gene transfer of the Notch-1 intracellular domain followed by culturing in the neurosphere method. As reported previously, BM-NPCs differentiated into neuronal cells in a highly selective manner in vitro. We assessed hind limb movements of the animals weekly for 7 weeks to monitor functional recovery after local injection of BM-NPCs to the transected site. To test the sensory recovery, we performed functional magnetic resonance imaging (fMRI) using electrical stimulation of the hind limbs. In the injured spinal cord, transplanted BM-NPCs were confirmed to express neuronal markers 7 weeks following the transplantation. Grafted cells successfully extended neurites beyond the transected portion of the spinal cord. Adjacent localization of synaptophysin and PSD-95 in the transplanted cells suggested synaptic formations. These results indicated survival and successful differentiation of BM-NPCs in the severely injured spinal cord. Importantly, rats that received BM-NPCs demonstrated significant motor recovery when compared to the vehicle injection group. Volumes of the fMRI signals in somatosensory cortex were larger in the BM-NPC-grafted animals. However, neuronal activity was diverse and not confined to the original hind limb territory in the somatosensory cortex. Therefore, reconstruction of neuronal networks was not clearly confirmed. Our results indicated BM-NPCs as an effective method to deliver neuronal lineage cells in a severely injured spinal cord. However, reestablishment of neuronal networks in completed transected spinal cord was still a challenging task.

  331. Neural correlates of deception in social contexts in normally developing children. International-journal Peer-reviewed

    Susumu Yokota, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Benjamin Thyreau, Mari Tanaka, Ryuta Kawashima

    Frontiers in human neuroscience　7　206-206　2013

    DOI： 10.3389/fnhum.2013.00206 　

    More details Close

    Deception is related to the ability to inhibit prepotent responses and to engage in mental tasks such as anticipating responses and inferring what another person knows, especially in social contexts. However, the neural correlates of deception processing, which requires mentalizing, remain unclear. Using functional magnetic resonance imaging (fMRI), we examined the neural correlates of deception, including mentalization, in social contexts in normally developing children. Healthy right-handed children (aged 8-9 years) were scanned while performing interactive games involving deception. The games varied along two dimensions: the type of reply (deception and truth) and the type of context (social and less social). Participants were instructed to deceive a witch and to tell the truth to a girl. Under the social-context conditions, participants were asked to consider what they inferred about protagonists' preferences from their facial expressions when responding to questions. Under the less-social-context conditions, participants did not need to consider others' preferences. We found a significantly greater response in the right precuneus under the social-context than under less-social-context conditions. Additionally, we found marginally greater activation in the right inferior parietal lobule (IPL) under the deception than under the truth condition. These results suggest that deception in a social context requires not only inhibition of prepotent responses but also engagement in mentalizing processes. This study provides the first evidence of the neural correlates of the mentalizing processes involved in deception in normally developing children.

  332. THE PSYCHOLOGICAL AND NEURAL REPRESENTATION OF SOCIAL NORMS IN MAKING A PURCHASE DECISION Peer-reviewed

    Yokoyama Ryoichi, Nozawa Takayuki, Sugiura Motoaki, Yomogida Yukihito, Takeuchi Hikaru, Akimoto Yoritaka, Kawashima Ryuta

    JOURNAL OF COGNITIVE NEUROSCIENCE　265-266　2013

    ISSN： 0898-929X

  333. Topological organization of functional brain networks in healthy children: differences in relation to age, sex, and intelligence. Peer-reviewed

    Wu K, Taki Y, Sato K, Hashizume H, Sassa Y, Takeuchi H, Thyreau B, He Y, Evans AC, Li X, Kawashima R, Fukuda H

    PloS one　8　(2)　e55347　2013

    DOI： 10.1371/journal.pone.0055347 　

    ISSN： 1932-6203

  334. Learning-dependent changes of associations between unfamiliar words and perceptual features: a 15-day longitudinal study Peer-reviewed

    Kambara Toshimune, Tsukiura Takashi, Shigemune Yayoi, Kanno Akitake, Nouchi Rui, Yomogida Yukihito, Kawashima Ryuta

    LANGUAGE SCIENCES　35　80-86　2013/01

    DOI： 10.1016/j.langsci.2012.05.001 　

    ISSN： 0388-0001

  335. Compensatory effort parallels midbrain deactivation during mental fatigue: an fMRI study. International-journal Peer-reviewed

    Seishu Nakagawa, Motoaki Sugiura, Yuko Akitsuki, S M Hadi Hosseini, Yuka Kotozaki, Carlos Makoto Miyauchi, Yukihito Yomogida, Ryoichi Yokoyama, Hikaru Takeuchi, Ryuta Kawashima

    PloS one　8　(2)　e56606　2013

    DOI： 10.1371/journal.pone.0056606 　

    More details Close

    Fatigue reflects the functioning of our physiological negative feedback system, which prevents us from overworking. When fatigued, however, we often try to suppress this system in an effort to compensate for the resulting deterioration in performance. Previous studies have suggested that the effect of fatigue on neurovascular demand may be influenced by this compensatory effort. The primary goal of the present study was to isolate the effect of compensatory effort on neurovascular demand. Healthy male volunteers participated in a series of visual and auditory divided attention tasks that steadily increased fatigue levels for 2 hours. Functional magnetic resonance imaging scans were performed during the first and last quarter of the study (Pre and Post sessions, respectively). Tasks with low and high attentional load (Low and High conditions, respectively) were administrated in alternating blocks. We assumed that compensatory effort would be greater under the High-attentional-load condition compared with the Low-load condition. The difference was assessed during the two sessions. The effect of compensatory effort on neurovascular demand was evaluated by examining the interaction between load (High vs. Low) and time (Pre vs. Post). Significant fatigue-induced deactivation (i.e., Pre>Post) was observed in the frontal, temporal, occipital, and parietal cortices, in the cerebellum, and in the midbrain in both the High and Low conditions. The interaction was significantly greater in the High than in the Low condition in the midbrain. Neither significant fatigue-induced activation (i.e., Pre<Post), nor its interaction with factor Load, was identified. The observed midbrain deactivation ([PreH - PostH]>[PreE- PostE]) may reflect suppression of the negative feedback system that normally triggers recuperative rest to maintain homeostasis.

  336. Use of semantic information to interpret thematic information for real-time sentence comprehension in an SOV language. Peer-reviewed

    Yokoyama S, Takahashi K, Kawashima R

    PloS one　8　e56106　2013

    Publisher: 2

    DOI： 10.1371/journal.pone.0056106 　

  337. Differential contributions of the inferior parietal and inferior frontal regions to the processing of grammatical and semantic relationships in wh-questions Peer-reviewed

    Kambara T, Tsukiura T, Yokoyama S, Takahashi K, Shigemune Y, Miyamoto T, Takahashi D, Sato S, Kawashima R

    Language sciences　37　14-21　2013

    DOI： 10.1016/j.langsci.2012.07.003 　

    ISSN： 0388-0001

  338. Brain training game boosts executive functions, working memory and processing speed in the young adults: a randomized controlled trial. International-journal Peer-reviewed

    Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Toshimune Kambara, Atsushi Sekiguchi, Carlos Makoto Miyauchi, Yuka Kotozaki, Haruka Nouchi, Ryuta Kawashima

    PloS one　8　(2)　e55518　2013

    Publisher: 2

    DOI： 10.1371/journal.pone.0055518 　

    ISSN： 1932-6203

    More details Close

    BACKGROUND: Do brain training games work? The beneficial effects of brain training games are expected to transfer to other cognitive functions. Yet in all honesty, beneficial transfer effects of the commercial brain training games in young adults have little scientific basis. Here we investigated the impact of the brain training game (Brain Age) on a wide range of cognitive functions in young adults. METHODS: We conducted a double-blind (de facto masking) randomized controlled trial using a popular brain training game (Brain Age) and a popular puzzle game (Tetris). Thirty-two volunteers were recruited through an advertisement in the local newspaper and randomly assigned to either of two game groups (Brain Age, Tetris). Participants in both the Brain Age and the Tetris groups played their game for about 15 minutes per day, at least 5 days per week, for 4 weeks. Measures of the cognitive functions were conducted before and after training. Measures of the cognitive functions fell into eight categories (fluid intelligence, executive function, working memory, short-term memory, attention, processing speed, visual ability, and reading ability). RESULTS AND DISCUSSION: Our results showed that commercial brain training game improves executive functions, working memory, and processing speed in young adults. Moreover, the popular puzzle game can engender improvement attention and visuo-spatial ability compared to playing the brain training game. The present study showed the scientific evidence which the brain training game had the beneficial effects on cognitive functions (executive functions, working memory and processing speed) in the healthy young adults. CONCLUSIONS: Our results do not indicate that everyone should play brain training games. However, the commercial brain training game might be a simple and convenient means to improve some cognitive functions. We believe that our findings are highly relevant to applications in educational and clinical fields. TRIAL REGISTRATION: UMIN Clinical Trial Registry 000005618.

  339. Association of hair iron levels with creativity and psychological variables related to creativity. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    Frontiers in human neuroscience　7　(DEC)　875-875　2013

    DOI： 10.3389/fnhum.2013.00875 　

    ISSN： 1662-5161

    More details Close

    Creativity generally involves the conception of original and valuable ideas. Previous studies have suggested an association between creativity and the dopaminergic system, and that physical activity facilitates creativity. Iron plays a key role in the dopaminergic system and physical activity. Here, we newly investigated the associations between hair iron levels and creativity, dopamine-related traits and states [novelty seeking, extraversion, and vigor (motivational state)], as well as the physical activity level. In the present study, we addressed this issue by performing a hair mineral analysis to determine iron levels and a behavioral creativity test of divergent thinking and related psychological measures among young adults (254 men, 88 women; mean age 20.79 ± 2.03 years). Iron levels did not show any significant association with creativity but displayed significant positive associations with novelty seeking, extraversion, and physical activity level. These results may be partly congruent with the notion that iron plays a key role in the dopaminergic system and imply that iron is important for traits and physical activity, which facilitate creativity. Future interventional or longitudinal studies are warranted to identify any causal effects.

  340. The association between resting functional connectivity and creativity. International-journal Peer-reviewed

    Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R

    Cerebral cortex (New York, N.Y. : 1991)　22　(12)　2921-2929　2012/12

    DOI： 10.1093/cercor/bhr371 　

    ISSN： 1047-3211

    More details Close

    The analysis of functional connectivity at rest (rFC) enables us to know how brain regions within and between networks interact. In this study, we used resting-state functional magnetic resonance imaging and a creativity test of divergent thinking (DT) to investigate the relationship between creativity measured by DT and rFC. We took the medial prefrontal cortex (mPFC) to be the seed region and investigated correlations across subjects between the score of the DT test and the strength of rFC between the mPFC and other brain regions. Our results showed that the strength of rFC with the mPFC significantly and positively correlated with creativity as measured by the DT test in the posterior cingulate cortex (PCC). These results showed that higher creativity measured by DT is associated with rFC between the mPFC and the PCC, the key nodes of the default mode network (DMN). Increased rFC between these regions is completely opposite from that is generally expected from the association between higher creativity and reduced deactivation in DMN during an externally directed attention-demanding task shown in our previous study but is similar to the pattern seen in relatives of schizophrenia. These findings are comparable to the previously reported psychological associations between schizotypy and creativity.

  341. A voxel-based morphometry study of gray and white matter correlates of a need for uniqueness. International-journal Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Hiroshi Hashizume, Seishu Nakagawa, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

    NeuroImage　63　(3)　1119-26　2012/11/15

    Publisher: 3

    DOI： 10.1016/j.neuroimage.2012.08.037 　

    ISSN： 1095-9572 1053-8119

    More details Close

    People appear to derive intrinsic satisfaction from the perception that they are unique, special, and separable from the masses, which is referred to as a need for uniqueness (NFU). NFU is a universal human trait, along with a tendency to conform to the beliefs and attitudes of others and social norms. We used voxel-based morphometry and a questionnaire to determine individual NFU and its association with brain structures in healthy men (94) and women (91; age, 21.3 ± 1.9 years). Individual NFU was associated with smaller gray matter volume of a cluster that included areas in (a) the left middle temporal gyrus, left superior temporal gyrus, and left superior temporal sulcus (STS); (b) the dorsal part of the anterior cingulate gyrus and the anterior part of the middle cingulate gyrus; and (c) the right inferior frontal gyrus and the ventral part of the precentral gyrus. Individual NFU was also associated with larger white matter concentration of a cluster that mainly included the body of the corpus callosum. These findings demonstrated that variations in NFU reflect the gray and white matter structures of focal regions. These findings suggest a biological basis for individual NFU, distributed across different gray and white matter areas of the brain.

  342. Rhythm information represented in the fronto-parieto-cerebellar motor system. International-journal Peer-reviewed

    Naho Konoike, Yuka Kotozaki, Shigehiro Miyachi, Carlos Makoto Miyauchi, Yukihito Yomogida, Yoritaka Akimoto, Koji Kuraoka, Motoaki Sugiura, Ryuta Kawashima, Katsuki Nakamura

    NeuroImage　63　(1)　328-38　2012/10/15

    DOI： 10.1016/j.neuroimage.2012.07.002 　

    ISSN： 1053-8119

    More details Close

    Rhythm is an essential element of human culture, particularly in language and music. To acquire language or music, we have to perceive the sensory inputs, organize them into structured sequences as rhythms, actively hold the rhythm information in mind, and use the information when we reproduce or mimic the same rhythm. Previous brain imaging studies have elucidated brain regions related to the perception and production of rhythms. However, the neural substrates involved in the working memory of rhythm remain unclear. In addition, little is known about the processing of rhythm information from non-auditory inputs (visual or tactile). Therefore, we measured brain activity by functional magnetic resonance imaging while healthy subjects memorized and reproduced auditory and visual rhythmic information. The inferior parietal lobule, inferior frontal gyrus, supplementary motor area, and cerebellum exhibited significant activations during both encoding and retrieving rhythm information. In addition, most of these areas exhibited significant activation also during the maintenance of rhythm information. All of these regions functioned in the processing of auditory and visual rhythms. The bilateral inferior parietal lobule, inferior frontal gyrus, supplementary motor area, and cerebellum are thought to be essential for motor control. When we listen to a certain rhythm, we are often stimulated to move our body, which suggests the existence of a strong interaction between rhythm processing and the motor system. Here, we propose that rhythm information may be represented and retained as information about bodily movements in the supra-modal motor brain system.

  343. Neurovascular uncoupling under mild hypoxic hypoxia: an EEG-fMRI study in rats. International-journal

    Akira Sumiyoshi, Hideaki Suzuki, Hiroaki Shimokawa, Ryuta Kawashima

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　32　(10)　1853-8　2012/10

    DOI： 10.1038/jcbfm.2012.111 　

    More details Close

    The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation=83.6±12.1%) induced significant reductions in fMRI responses (P<0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen saturation were linearly correlated with the changes in the fMRI responses. These data further emphasize the importance of oxygen availability, which may regulate neurovascular coupling via the oxygen-dependent enzymatic synthesis of messenger molecules.

  344. Beneficial effects of short-term combination exercise training on diverse cognitive functions in healthy older people: study protocol for a randomized controlled trial. International-journal Peer-reviewed

    Nouchi R, Taki Y, Takeuchi H, Hashizume H, Nozawa T, Sekiguchi A, Nouchi H, Kawashima R

    Trials　13　200-200　2012/10

    DOI： 10.1186/1745-6215-13-200 　

    ISSN： 1745-6215

    More details Close

    BACKGROUND: Results of previous studies have shown that exercise training can improve cognitive functions in healthy older people. Some studies have demonstrated that long-term combination exercise training can facilitate memory function improvement better than either aerobic or strength exercise training alone. Nevertheless, it remains unclear whether short-term combination exercise training can improve diverse cognitive functions in healthy older people or not. We investigate the effects of four weeks of short-term combination exercise training on various cognitive functions (executive functions, episodic memory, short-term memory, working memory, attention, reading ability, and processing speed) of healthy older people. METHODS: A single-blinded intervention with two parallel groups (combination exercise training; waiting list control) is used. Testers are blind to the study hypothesis and the participants' group membership. Through an advertisement in a local newspaper, 64 healthy older adults are recruited and then assigned randomly to a combination exercise training group or a waiting list control group. Participants in the combination exercise training group must participate in the short-term combination exercise training (aerobic and strength exercise training) three days per week during the four weeks (12 workouts in total). The waiting list group does not participate in the combination exercise training. The primary outcome measure is the Stroop test score: a measure of executive function. Secondary outcome measures are assessments including the Verbal Fluency Task, Logical Memory, First and Second Names, Digit Span Forward, Digit span backward, Japanese Reading Test, Digit Cancellation Task, Digit Symbol Coding, and Symbol Search. We assess these outcome measures before and after the intervention. DISCUSSION: This report is the first of a study that investigates the beneficial effects of short-term combination exercise training on diverse cognitive functions of older people. Our study is expected to provide sufficient evidence of short-term combination exercise's effectiveness. TRIAL REGISTRATION: This trial was registered in The University Hospital Medical Information Network Clinical Trials Registry (Number UMIN000007828).

  345. 健常成人の加齢における局所脳灰白質量の減少 383人の脳MRI解析による縦断研究

    瀧 靖之, 木之村 重男, 佐藤 和則, 後藤 了以, Wu Kai, 川島 隆太, 福田 寛

    日本老年医学会雑誌　49　(5)　654-654　2012/09

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  346. Pitfalls in the dipolar model for the neocortical EEG sources Peer-reviewed

    Jorge J. Riera, Takeshi Ogawa, Takakuni Goto, Akira Sumiyoshi, Hiroi Nonaka, Alan Evans, Hiroyoshi Miyakawa, Ryuta Kawashima

    JOURNAL OF NEUROPHYSIOLOGY　108　(4)　956-975　2012/08

    DOI： 10.1152/jn.00098.2011 　

    ISSN： 0022-3077

  347. L2 sentence comprehension by Japanese learners of English with different proficiency levels

    YOKOYAMA SATORU, MANALO EMMANUEL, TANAKA ERISUNOBUE, TAKAHASHI KEI, HASHIZUME HIROSHI, JEONG HEYONGJEONG, KAWASHIMA RYUTA

    電子情報通信学会技術研究報告　112　(145(TL2012 10-25))　13-17　2012/07/14

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    Processing speed can be considered as one aspect of proficiency of foreign language. In this study, we measured processing speed of English sentence comprehension by Japanese learners, and examined the relationship between their speed and their proficiency level of English. To this end, we used self-paced reading task of English sentences and Minimal English Test (MET) as an English proficiency test. In this paper, we report the preliminary results.

  348. Effects of processing speed training on cognitive functions and neural systems Invited

    Hikaru Takeuchi, Ryuta Kawashima

    REVIEWS IN THE NEUROSCIENCES　23　(3)　289-301　2012/06

    DOI： 10.1515/revneuro-2012-0035 　

    ISSN： 0334-1763

  349. The Partial Incremental Argument Interpretation Model: A Real Time Simplex Sentence Comprehension Model of Japanese Language Peer-reviewed

    Satoru Yokoyama, Kei Yoshimoto, Ryuta Kawashima

    Psychology of Language　159-183　2012/06

    More details Close

    Chapter 5

  350. Virtual Walking System for Smart Aging Peer-reviewed

    Norihiro Sugita, Ryota Sugihara, Makoto Yoshizawa, Noriyasu Homma, Makoto Abe, Ryuta Kawashima

    TVRSJ　17　(4)　497-504　2012/05

    Publisher: THE VIRTUAL REALITY SOCIETY OF JAPAN

    DOI： 10.18974/tvrsj.17.4_497 　

    ISSN： 1344-011X

    More details Close

    In this study, a novel virtual walking system has been developed for putting the concept of advocating a positive acceptance of the later stages of life or aging, called smart aging, into practice. An essential core of the system can be found in striking the right balance between virtual and real worlds for old people to use pleasantly and safely. The system consists of a laptop computer, micro-projectors, and a completely new screen system mounted on the walking frame, called "walking frame mounted display (WFMD)." Users can physically walk with pleasure by the virtual reality technology and safely by the WFMD in the virtual environment. Furthermore, the WFMD does not require any sensors to be worn and is sufficiently inexpensive for home use. Comparison of experimental results clearly demonstrates that the real walking in a virtual environment using the WFMD is easier to use for old people than stamping their feet on the "Wii balance board" in the same environment.

  351. The correlation between brain gray matter volume and empathizing and systemizing quotients in healthy children. International-journal Peer-reviewed

    Sassa Y, Taki Y, Takeuchi H, Hashizume H, Asano M, Asano K, Wakabayashi A, Kawashima R

    NeuroImage　60　(4)　2035-2041　2012/05

    DOI： 10.1016/j.neuroimage.2012.02.021 　

    ISSN： 1053-8119

    More details Close

    The abilities to empathize and to systemize, two fundamental dimensions of cognitive style, are characterized by apparent individual differences. These abilities are typically measured using an empathizing quotient (EQ) and a systemizing quotient (SQ) questionnaire, respectively. The purpose of this study was to reveal any correlations between EQ and SQ scores and regional gray matter volumes in healthy children by applying voxel-based morphometry to magnetic resonance images. We collected MRIs of brain structure and administered children's versions of the EQ and SQ questionnaires (EQ-C and SQ-C, respectively) to 261 healthy children aged 5-15 years. Structural MRI data were segmented, normalized, and smoothed using an optimized voxel-based morphometric analysis. Next, we analyzed the correlation between regional gray matter volume and EQ-C and SQ-C scores adjusting for age, sex, and intracranial volume. The EQ-C scores showed significant positive correlations with the regional gray matter volumes of the left fronto-opercular and superior temporal cortices, including the precentral gyrus, the inferior frontal gyrus, the superior temporal gyrus, and the insula, which are functionally related to empathic processing. Additionally, SQ-C scores showed a significant negative correlation with the regional gray matter volume of the left posterior parietal cortex, which is functionally involved in selective attention processing. Our findings suggest that individual differences in cognitive style pertaining to empathizing or systemizing abilities could be explained by differences in the volume of brain structures that are functionally relevant to empathizing and systemizing.

  352. Brain structural changes as vulnerability factors and acquired signs of post-earthquake stress. Peer-reviewed

    Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R

    Molecular psychiatry　18　(5)　618-623　2012/05

    DOI： 10.1038/mp.2012.51 　

    ISSN： 1359-4184

    eISSN： 1476-5578

  353. Beneficial effects of reading aloud and solving simple arithmetic calculations (learning therapy) on a wide range of cognitive functions in the healthy elderly: study protocol for a randomized controlled trial. International-journal Peer-reviewed

    Nouchi R, Taki Y, Takeuchi H, Hashizume H, Nozawa T, Sekiguchi A, Nouchi H, Kawashima R

    Trials　13　32-32　2012/04

    DOI： 10.1186/1745-6215-13-32 　

    ISSN： 1745-6215

    More details Close

    BACKGROUND: Almost all cognitive functions decline with age. Results of previous studies have shown that cognitive training related to everyday life (reading aloud and solving simple arithmetic calculations), namely learning therapy, can improve two cognitive function (executive functions and processing speed) in elderly people. However, it remains unclear whether learning therapy engenders improvement of various cognitive functions or not. We investigate the impact of learning therapy on various cognitive functions (executive functions, episodic memory, short-term memory, working memory, attention, reading ability, and processing speed) in healthy older adults. METHODS: We use a single-blinded intervention with two parallel groups (a learning therapy group and a waiting list control group). Testers are blind to the study hypothesis and the group membership of participants. Through an advertisement in local newspaper, 64 healthy older adults are recruited. They will be assigned randomly to a learning therapy group or a waiting list control group. In the learning therapy group, participants are required to perform two cognitive tasks for 6 months: reading Japanese aloud and solving simple calculations. The waiting list group does not participate in the intervention. The primary outcome measure is the Stroop test score: a measure of executive function. Secondary outcome measures are assessments including the following: verbal fluency task, logical memory, first and second names, digit span forward, digit span backward, Japanese reading test, digit cancellation task, digit symbol coding, and symbol search. We assess these outcome measures before and after the intervention. DISCUSSION: This report is the first study which investigates the beneficial effects of learning therapy on a wide range of cognitive functions of elderly people. Our study provides sufficient evidence of learning therapy effectiveness. Most cognitive functions, which are correlated strongly with daily life activities, decrease with age. These study results can elucidate effects of cognitive training on elderly people. TRIAL REGISTRATION: This trial was registered in The University Hospital Medical Information Network Clinical Trials Registry (No. UMIN000006998).

  354. ヒト脳の正常発達・加齢に伴う脳形態およびネットワーク構造の変化 健常日本人脳MR画像データベースを用いた画像医学的研究

    福田 寛, 瀧 靖之, Wu Kai, 佐藤 和則, 後藤 了以, 井上 健太郎, 岡田 賢, 秋本 達也, 川島 隆太

    ナノ医工学年報　5　(1)　91-100　2012/03

    Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」

    ISSN： 1882-4692

  355. Age-related changes in topological organization of structural brain networks in healthy individuals Peer-reviewed

    Kai Wu, Yasuyuki Taki, Kazunori Sato, Shigeo Kinomura, Ryoi Goto, Ken Okada, Ryuta Kawashima, Yong He, Alan C. Evans, Hiroshi Fukuda

    HUMAN BRAIN MAPPING　33　(3)　552-568　2012/03

    DOI： 10.1002/hbm.21232 　

    ISSN： 1065-9471

    eISSN： 1097-0193

  356. Coupling between gamma oscillation and fMRI signal in the rat somatosensory cortex: its dependence on systemic physiological parameters. International-journal Peer-reviewed

    Akira Sumiyoshi, Hideaki Suzuki, Takeshi Ogawa, Jorge J Riera, Hiroaki Shimokawa, Ryuta Kawashima

    NeuroImage　60　(1)　738-46　2012/03

    DOI： 10.1016/j.neuroimage.2011.12.082 　

    More details Close

    The simultaneous recordings of neuronal and hemodynamic signals have revealed a significant involvement of high frequency bands (e.g., gamma range, 25-70 Hz) in neurovascular coupling. However, the dependence on a physiological parameter is unknown. In this study, we performed simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings in 12 Wistar rats using a conventional forepaw stimulation paradigm and concurrently monitored the systemic physiological parameters of the partial pressure of arterial oxygen, partial pressure of arterial carbon dioxide, pH, mean arterial blood pressure, and heart rate through the rat femoral artery. The high frequency bands in the artifact-free EEG signals, especially those in the gamma range, demonstrated a maximum correlation with fMRI signals in the rat somatosensory cortex. A multiple linear regression analysis demonstrated that the correlation coefficient between the gamma power and fMRI signal depended on the actual values of the physiological parameters (R(2)=0.20, p<0.05), whereas the gamma power and fMRI signal by itself were independent. Among the parameters, the heart rate had a statistically significant slope (95% CI: 0.00027-0.0016, p<0.01) in a multiple linear regression model. These results indicate that neurovascular coupling is mainly driven by gamma oscillations, as expected, but coupling or potential decoupling is strongly influenced by systemic physiological parameters, which dynamically reflect the baseline vital status of the subject.

  357. 健常成人の高感度C反応性蛋白と局所脳灰白質量との相関

    瀧 靖之, 木之村 重男, 佐藤 和則, 後藤 了以, 福田 寛, 川島 隆太

    日本医学放射線学会学術集会抄録集　71回　S199-S199　2012/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  358. Regional gray and white matter volume associated with Stroop interference: evidence from voxel-based morphometry. International-journal Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R

    NeuroImage　59　(3)　2899-2907　2012/02

    Publisher: 3

    DOI： 10.1016/j.neuroimage.2011.09.064 　

    ISSN： 1095-9572 1053-8119

    More details Close

    During Stroop tasks, subjects experience cognitive interference when they resolve interferences such as identifying the ink color of a printed word while ignoring the word's identity. Stroop paradigms are commonly used as an index of attention deficits and a tool for investigating the functions of the frontal lobes and other associated structures. Despite these uses and the vast amount of attention given to Stroop paradigms, the regional gray matter volume/regional white matter volume (rGMV/rWMV) correlates of Stroop interference have not yet been identified at the whole brain level in normal adults. We examined this issue using voxel-based morphometry in right-handed healthy young adults. We found significant negative relationships between the Stroop interference rate and rGMV in the anterior cingulate cortex (ACC), right inferior frontal gyrus, and cerebellum. Furthermore, we found relationships between the Stroop interference rate and rWMV in bilateral anatomical clusters that extended around extensive WM regions in the dorsal part of the frontal lobe. These findings are the first to reveal rGMV/rWMV that underlie the performance of the Stroop task, a widely used psychological paradigm at the whole brain level. Of note, our findings support the notion that ACC contributes to Stroop performance and show the involvement of regions that have been implicated in response inhibition and attention.

  359. Self-face evaluation and self-esteem in young females: an fMRI study using contrast effect. Peer-reviewed

    Oikawa H, Sugiura M, Sekiguchi A, Tsukiura T, Miyauchi CM, Hashimoto T, Takano-Yamamoto T, Kawashima R

    NeuroImage　59　(4)　3668-3676　2012/02

    Publisher: 4

    DOI： 10.1016/j.neuroimage.2011.10.098 　

    ISSN： 1095-9572 1053-8119

  360. Brain development in childhood. Peer-reviewed

    Taki Y, Kawashima R

    The open neuroimaging journal　6　103-110　2012

    DOI： 10.2174/1874440001206010103 　

  361. Neural substrates of grammatical information retrieval during sentence comprehension.

    Kei Takahashi, Satoru Yokoyama, Toshimune Kambara, Ryuta Kawashima

    2012

  362. Effects of the Higashi-Nihon earthquake: posttraumatic stress, psychological changes, and cortisol levels of survivors. International-journal Peer-reviewed

    Yuka Kotozaki, Ryuta Kawashima

    PloS one　7　(4)　e34612　2012

    DOI： 10.1371/journal.pone.0034612 　

    eISSN： 1932-6203

  363. Effect of the survival judgment task on memory performance in subclinically depressed people Peer-reviewed

    Rui Nouchi, Ryuta Kawashima

    FRONTIERS IN PSYCHOLOGY　3　114　2012

    DOI： 10.3389/fpsyg.2012.00114 　

    ISSN： 1664-1078

  364. Clinical application of magnetoencephalography

    Akitake Kanno, Nobukazu Nakasato, Ryuta Kawashima

    Journal of the Institute of Electrical Engineers of Japan　132　(5)　290-293　2012/01/01

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejjournal.132.290 　

    ISSN： 1340-5551

  365. Sleep duration during weekdays affects hippocampal gray matter volume in healthy children. International-journal Peer-reviewed

    Yasuyuki Taki, Hiroshi Hashizume, Benjamin Thyreau, Yuko Sassa, Hikaru Takeuchi, Kai Wu 0002, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

    NeuroImage　60　(1)　471-475　2012

    DOI： 10.1016/j.neuroimage.2011.11.072 　

    ISSN： 1053-8119

    More details Close

    Sleep is essential for living beings, and sleep loss has been shown to affect hippocampal structure and function in rats by inhibiting cell proliferation and neurogenesis in this region of the brain. We aimed to analyze the correlation between sleep duration and the hippocampal volume using brain magnetic resonance images of 290 healthy children aged 5-18 years. We examined the volume of gray matter, white matter, and the cerebrospinal fluid (CSF) space in the brain using a fully automated and established neuroimaging technique, voxel-based morphometry, which enabled global analysis of brain structure without bias towards any specific brain region while permitting the identification of potential differences or abnormalities in brain structures. We found that the regional gray matter volume of the bilateral hippocampal body was significantly positively correlated with sleep duration during weekdays after adjusting for age, sex, and intracranial volume. Our results indicated that sleep duration affects the hippocampal regional gray matter volume of healthy children. These findings advance our understanding of the importance of sleep habits in the daily lives of healthy children.

  366. Correlation among body height, intelligence, and brain gray matter volume in healthy children. International-journal Peer-reviewed

    Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Kohei Asano, Yuka Kotozaki, Rui Nouchi, Kai Wu 0002, Hiroshi Fukuda, Ryuta Kawashima

    NeuroImage　59　(2)　1023-1027　2012

    DOI： 10.1016/j.neuroimage.2011.08.092 　

    ISSN： 1053-8119

    More details Close

    A significant positive correlation between height and intelligence has been demonstrated in children. Additionally, intelligence has been associated with the volume of gray matter in the brains of children. Based on these correlations, we analyzed the correlation among height, full-scale intelligence quotient (IQ) and gray matter volume applying voxel-based morphometry using data from the brain magnetic resonance images of 160 healthy children aged 5-18 years of age. As a result, body height was significantly positively correlated with brain gray matter volume. Additionally, the regional gray matter volume of several regions such as the bilateral prefrontal cortices, temporoparietal region, and cerebellum was significantly positively correlated with body height and that the gray matter volume of several of these regions was also significantly positively correlated with full-scale intelligence quotient (IQ) scores after adjusting for age, sex, and socioeconomic status. Our results demonstrate that gray and white matter volume may mediate the correlation between body height and intelligence in healthy children. Additionally, the correlations among gray and white matter volume, height, and intelligence may be at least partially explained by the effect of insulin-like growth factor-1 and growth hormones. Given the importance of the effect of environmental factors, especially nutrition, on height, IQ, and gray matter volume, the present results stress the importance of nutrition during childhood for the healthy maturation of body and brain.

  367. An Examination of L2 Proficiency and L2 Vocabulary Processing Speed : Evidence from Reaction Times of Lexical Decision Task and Semantic Decision Task

    7　(7)　35-42　2012

    Publisher:

    ISSN： 1881-0853

  368. Neuro-typology of sentence comprehension: Cross-linguistic difference in canonical word order affects brain responses during sentence comprehension. Peer-reviewed

    Hashimoto Y, Yokoyama S, Kawashima R

    The Open Medical Imaging Journal　6　62-69　2012

    DOI： 10.2174/1874347101206010062 　

  369. Left Inferior Frontal Activations Differentially Modulated by Scrambling in Ditransitive Sentences Peer-reviewed

    Koizumi M, Kim J, Kimura N, Yokoyama S, Sato S, Horie K, Kawashima R

    The Open Medical Imaging Journal　6　70-79　2012

    DOI： 10.2174/1874347101206010070 　

  370. Mechanism of case processing in the brain: an fMRI study. Peer-reviewed

    Yokoyama S, Maki H, Hashimoto Y, Toma M, Kawashima R

    PloS one　7　e40474　2012

    Publisher: 7

    DOI： 10.1371/journal.pone.0040474 　

  371. Brain training game improves executive functions and processing speed in the elderly: a randomized controlled trial. International-journal Peer-reviewed

    Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Yuko Akitsuki, Yayoi Shigemune, Atsushi Sekiguchi, Yuka Kotozaki, Takashi Tsukiura, Yukihito Yomogida, Ryuta Kawashima

    PloS one　7　(1)　e29676　2012

    Publisher: 1

    DOI： 10.1371/journal.pone.0029676 　

    ISSN： 1932-6203

    More details Close

    BACKGROUND: The beneficial effects of brain training games are expected to transfer to other cognitive functions, but these beneficial effects are poorly understood. Here we investigate the impact of the brain training game (Brain Age) on cognitive functions in the elderly. METHODS AND RESULTS: Thirty-two elderly volunteers were recruited through an advertisement in the local newspaper and randomly assigned to either of two game groups (Brain Age, Tetris). This study was completed by 14 of the 16 members in the Brain Age group and 14 of the 16 members in the Tetris group. To maximize the benefit of the interventions, all participants were non-gamers who reported playing less than one hour of video games per week over the past 2 years. Participants in both the Brain Age and the Tetris groups played their game for about 15 minutes per day, at least 5 days per week, for 4 weeks. Each group played for a total of about 20 days. Measures of the cognitive functions were conducted before and after training. Measures of the cognitive functions fell into four categories (global cognitive status, executive functions, attention, and processing speed). Results showed that the effects of the brain training game were transferred to executive functions and to processing speed. However, the brain training game showed no transfer effect on any global cognitive status nor attention. CONCLUSIONS: Our results showed that playing Brain Age for 4 weeks could lead to improve cognitive functions (executive functions and processing speed) in the elderly. This result indicated that there is a possibility which the elderly could improve executive functions and processing speed in short term training. The results need replication in large samples. Long-term effects and relevance for every-day functioning remain uncertain as yet. TRIAL REGISTRATION: UMIN Clinical Trial Registry 000002825.

  372. Neural correlates of the difference between working memory speed and simple sensorimotor speed: an fMRI study. Peer-reviewed

    Takeuchi H, Sugiura M, Sassa Y, Sekiguchi A, Yomogida Y, Taki Y, Kawashima R

    PloS one　7　(1)　e30579　2012

    Publisher: 1

    DOI： 10.1371/journal.pone.0030579 　

    ISSN： 1932-6203

  373. White matter structures associated with emotional intelligence: Evidence from diffusion tensor imaging. International-journal Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Nagase T, Nouchi R, Fukushima A, Kawashima R

    Human brain mapping　34　(5)　1025-1034　2011/12

    DOI： 10.1002/hbm.21492 　

    ISSN： 1097-0193 1065-9471

    More details Close

    Previous studies of brain lesions, functional activity, and gray matter structures have suggested that emotional intelligence (EI) is associated with regions involved in the network of social cognition (SCN) and in somatic marker circuitry (SMC). Our new study is the first to investigate the association between white matter (WM) integrity and EI. We examined this relationship in the brain of healthy young adult men [n = 74, mean age = 21.5 years, standard deviation (SD) = 1.6] and women (n = 44, mean age = 21.9 years, SD = 1.4). We performed a voxel-based analysis of fractional anisotropy, which is an indicator of WM integrity, using diffusion tensor imaging and used a questionnaire (EI Scale) for measuring EI to identify the correlation of WM integrity with individual EI factor (intrapersonal, interpersonal, and situation management factors). Our results showed that (a) the intrapersonal factor of EI was positively correlated with WM integrity in the right anterior insula, and (b) the interpersonal factor of EI was associated with WM integrity in a part of the right inferior longitudinal fasciculus (ILF). The right anterior insula is one of the important nodes of the SMC, whereas the ILF connects the visual cortex and areas related to SCN, and thus, is a part of the SCN. Our findings further support the notion that the brain regions involved in the SCN and in the SMC are associated with EI.

  374. Correlation between gray matter density-adjusted brain perfusion and age using brain MR images of 202 healthy children. Peer-reviewed

    Taki Y, Hashizume H, Sassa Y, Takeuchi H, Wu K, Asano M, Asano K, Fukuda H, Kawashima R

    Human brain mapping　32　(11)　1973-1985　2011/11

    DOI： 10.1002/hbm.21163 　

    ISSN： 1065-9471

  375. Large-scale heterogeneous representation of sound attributes in rat primary auditory cortex: from unit activity to population dynamics. International-journal Peer-reviewed

    Takeshi Ogawa, Jorge Riera, Takakuni Goto, Akira Sumiyoshi, Hiroi Nonaka, Karim Jerbi, Olivier Bertrand, Ryuta Kawashima

    The Journal of neuroscience : the official journal of the Society for Neuroscience　31　(41)　14639-53　2011/10/12

    DOI： 10.1523/JNEUROSCI.0086-11.2011 　

    More details Close

    Recent evidence indicates the existence of pyramidal cells (PCs) and interneurons with nontrivial tuning characteristics for sound attributes in the primary auditory cortex (A1) of mammals. These neurons are functionally distributed into layers and sparsely organized at a small scale. However, their topological locations at a large scale in A1 have not yet been investigated. Furthermore, these neurons are usually classified from fine maps of attribute-dependent spiking activity, and not much attention is paid to population postsynaptic potentials related to their activity. We used extracellular recordings obtained from multiple sites in A1 of adult rats to determine neuronal codifiers for sound attributes defined by coarse representations of the population dose-response curves. We demonstrated that these codifiers, majorly involving PCs, are heterogeneously distributed along A1. Spiking activity in these neurons during stimulation was correlated to β (12-25 Hz) and low γ (25-70 Hz) postsynaptic oscillations in the infragranular layer, whereas in the supragranular layer, better correlations were found with high γ (70-170 Hz) oscillations. The time-frequency analysis of the postsynaptic potentials showed a transient broadband power increase in all layers after the stimulus onset that was followed by a sustained high γ oscillation in the supragranular layer, fluctuations in the laminar content of the low-frequency oscillations, and a global attenuation in the low-frequency powers after the stimulus offset that happened together with a long-lasting strengthening of the β oscillations. We concluded that, for rats, sounds are codified in A1 by segregated networks of specialized PCs whose postsynaptic activity impinges on the emergence of sparse/dense spiking patterns.

  376. Gender differences in partial-volume corrected brain perfusion using brain MRI in healthy children. Peer-reviewed

    Taki Y, Hashizume H, Sassa Y, Takeuchi H, Wu K, Asano M, Asano K, Fukuda H, Kawashima R

    NeuroImage　58　(3)　709-715　2011/10

    DOI： 10.1016/j.neuroimage.2011.07.020 　

    ISSN： 1053-8119

  377. Second-language instinct and instruction effects: nature and nurture in second-language acquisition. International-journal Peer-reviewed

    Yusa N, Koizumi M, Kim J, Kimura N, Uchida S, Yokoyama S, Miura N, Kawashima R, Hagiwara H

    Journal of cognitive neuroscience　23　(10)　2716-2730　2011/10

    Publisher: 10

    DOI： 10.1162/jocn.2011.21607 　

    ISSN： 0898-929X

    More details Close

    Adults seem to have greater difficulties than children in acquiring a second language (L2) because of the alleged "window of opportunity" around puberty. Postpuberty Japanese participants learned a new English rule with simplex sentences during one month of instruction, and then they were tested on "uninstructed complex sentences" as well as "instructed simplex sentences." The behavioral data show that they can acquire more knowledge than is instructed, suggesting the interweaving of nature (universal principles of grammar, UG) and nurture (instruction) in L2 acquisition. The comparison in the "uninstructed complex sentences" between post-instruction and pre-instruction using functional magnetic resonance imaging reveals a significant activation in Broca's area. Thus, this study provides new insight into Broca's area, where nature and nurture cooperate to produce L2 learners' rich linguistic knowledge. It also shows neural plasticity of adult L2 acquisition, arguing against a critical period hypothesis, at least in the domain of UG.

  378. Neural bases of a specific strategy for visuospatial processing in rugby players. International-journal Peer-reviewed

    Sekiguchi A, Yokoyama S, Kasahara S, Yomogida Y, Takeuchi H, Ogawa T, Taki Y, Niwa S, Kawashima R

    Medicine and science in sports and exercise　43　(10)　1857-1862　2011/10

    Publisher: 10

    DOI： 10.1249/MSS.0b013e31821920f3 　

    ISSN： 1530-0315 0195-9131

    More details Close

    INTRODUCTION: Rugby is one of the most tactically complex sports. Rugby coaching theory suggests that rugby players need to possess various cognitive abilities. A previous study claimed that rugby players have high visuospatial awareness, which is induced by a strategy described as taking a "bird's eye view." METHODS: To examine if there were differential cortical networks related to visuospatial processing tasks among top-level rugby players and control novices, we compared brain activities during a visuospatial processing task between 20 male top-level rugby players (Top) and 20 control novice males (Novice) using functional magnetic resonance imaging (fMRI). To avoid the effect of differential behavioral performances on brain activation, we recruited novices whose visuospatial ability was expected to match that of the rugby players. We adopted a 3-D mental rotation task during fMRI scanning as a visuospatial processing task. RESULTS: Significantly greater activations from baseline were observed for the Top group than for the Novice group in the right superior parietal lobe and lateral occipital cortex. Significantly greater deactivations from baseline were observed for the Top group than for the Novice group in the right medial prefrontal cortex. CONCLUSIONS: The discrepancy between psychobehavioral outputs and the fMRI results suggested the existence of a cognitive strategy among top-level rugby players that differs from that among control novices. The greater activation of the right superior parietal lobe and lateral occipital cortex in top-level rugby players suggested a strategy involving visuospatial cognitive processing with respect to the bird's eye view. In addition, the right medial prefrontal cortex is known to be a part of the default mode networks, suggesting an additional cognitive load for the Top group when using the bird's-eye-view strategy. This further supported the existence of a specific cognitive strategy among top-level rugby players.

  379. Verbal working memory performance correlates with regional white matter structures in the frontoparietal regions. Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

    Neuropsychologia　49　(12)　3466-3473　2011/10

    Publisher: 12

    DOI： 10.1016/j.neuropsychologia.2011.08.022 　

    ISSN： 1873-3514 0028-3932

  380. Effect of Parent-and-Child Cooking on Cognitive Functions of Children : Daily Intervention Program and Measurement with Near Infrared Spectroscopy

    YAMASHITA Machiko, KAWASHIMA Ryuta, SASSA Yuko, YAMAMOTO Kazue, TAKAKURA Mika, MINAMI Kimiko, ONISHI Tetsuya

    Journal for the Integrated Study of Dietary Habits　22　(2)　88-97　2011/09/30

    Publisher: THE JAPAN ASSOCIATION FOR THE INTEGRATED STUDY OF DIETARY HABITS

    DOI： 10.2740/jisdh.22.88 　

    ISSN： 1346-9770

  381. Cerebral Blood Flow during Rest Associates with General Intelligence and Creativity Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, Ryuta Kawashima

    PLOS ONE　6　(9)　e25532　2011/09

    DOI： 10.1371/journal.pone.0025532 　

    ISSN： 1932-6203

  382. Regional gray matter density associated with emotional intelligence: evidence from voxel-based morphometry. Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

    Human brain mapping　32　(9)　1497-1510　2011/09

    Publisher: 9

    DOI： 10.1002/hbm.21122 　

    ISSN： 1097-0193 1065-9471

  383. Neural bases of human mate choice: Multiple value dimensions, sex difference, and self-assessment system. Peer-reviewed

    Funayama R, Sugiura M, Sassa Y, Jeong H, Wakusawa K, Horie K, Sato S, Kawashima R

    Social neuroscience　7　(1)　59-73　2011/09

    DOI： 10.1080/17470919.2011.580120 　

    ISSN： 1747-0919

  384. Changes in Neural Correlates of Outcome Feedback Processing During Implicit Learning Peer-reviewed

    M.Rostami, S.M.H.Hosseini, M.Takahashi, M.Sugiura, R.Kawashima

    The Open Neuroscience Journal　5　24-30　2011/08/02

    DOI： 10.2174/1874082001105010024 　

  385. Quantifying the Uncertainty of Spontaneous Ca2+ Oscillations in Astrocytes: Particulars of Alzheimer&apos;s Disease Peer-reviewed

    J. Riera, R. Hatanaka, T. Uchida, T. Ozaki, R. Kawashima

    BIOPHYSICAL JOURNAL　101　(3)　554-564　2011/08

    DOI： 10.1016/j.bpj.2011.06.041 　

    ISSN： 0006-3495

  386. Effects of Training of Processing Speed on Neural Systems Peer-reviewed

    Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, Ryuta Kawashima

    JOURNAL OF NEUROSCIENCE　31　(34)　12139-12148　2011/08

    DOI： 10.1523/JNEUROSCI.2948-11.2011 　

    ISSN： 0270-6474

  387. The representation of social interaction in episodic memory: a functional MRI study. Peer-reviewed

    Mano Y, Sugiura M, Tsukiura T, Chiao JY, Yomogida Y, Jeong H, Sekiguchi A, Kawashima R

    NeuroImage　57　(3)　1234-1242　2011/08

    Publisher: 3

    DOI： 10.1016/j.neuroimage.2011.05.016 　

    ISSN： 1053-8119

  388. Correlation between degree of white matter hyperintensities and global gray matter volume decline rate Peer-reviewed

    Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

    NEURORADIOLOGY　53　(6)　397-403　2011/06

    DOI： 10.1007/s00234-010-0746-x 　

    ISSN： 0028-3940

  389. A longitudinal study of gray matter volume decline with age and modifying factors Peer-reviewed

    Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Ryuta Kawashima, Hiroshi Fukuda

    NEUROBIOLOGY OF AGING　32　(5)　907-915　2011/05

    DOI： 10.1016/j.neurobiolaging.2009.05.003 　

    ISSN： 0197-4580

  390. Neural Substrates of Decision Making in Irritable Bowel Syndrome Peer-reviewed

    Aizawa Emiko, Kochiyama Takanori, Sato Yasuhiro, Morishita Joe, Sekiguchi Atsushi, Kolnzaki Yuka, Kano Michiko, Kanazawa Motoyori, Sugiura Motoaki, Kawashima Ryuta, Mushiake Hajime, Fukudo Shin

    GASTROENTEROLOGY　140　(5)　S365　2011/05

    ISSN： 0016-5085

  391. Self-face recognition in social context. Peer-reviewed

    Sugiura M, Sassa Y, Jeong H, Wakusawa K, Horie K, Sato S, Kawashima R

    Human brain mapping　33　(6)　1364-1374　2011/05

    DOI： 10.1002/hbm.21290 　

    ISSN： 1065-9471

  392. Decoding what one likes or dislikes from single-trial fNIRS measurements Peer-reviewed

    Hosseini S. M. Hadi, Mano Yoko, Rostami Maryam, Takahashi Makoto, Sugiura Motoaki, Kawashima Ryuta

    NEUROREPORT　22　(6)　269-273　2011/04/20

    DOI： 10.1097/WNR.0b013e3283451f8f 　

    ISSN： 0959-4965

  393. 誘発反応の新しい概念 Time-frequency analysis

    菅野 彰剛, 川島 隆太

    医学検査　60　(4)　435-435　2011/04

    Publisher: (一社)日本臨床衛生検査技師会

    ISSN： 0915-8669

    eISSN： 2188-5346

  394. ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化 健常日本人脳MR画像データベースを用いた画像医学的研究

    福田 寛, 滝 靖之, Wu Kai, 木之村 重男, 佐藤 和則, 井上 健太郎, 後藤 了以, 岡田 賢, 川島 隆太

    ナノ医工学年報　4　(1)　89-98　2011/03

    Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」

    ISSN： 1882-4692

  395. Correlation between gray/white matter volume and cognition in healthy elderly people Peer-reviewed

    Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

    BRAIN AND COGNITION　75　(2)　170-176　2011/03

    DOI： 10.1016/j.bandc.2010.11.008 　

    ISSN： 0278-2626

  396. Failing to deactivate: the association between brain activity during a working memory task and creativity. International-journal Peer-reviewed

    Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R

    NeuroImage　55　(2)　681-687　2011/03

    DOI： 10.1016/j.neuroimage.2010.11.052 　

    ISSN： 1053-8119

    More details Close

    Working memory (WM) is an essential component for human higher order cognitive activities. Creativity has been essential to the development of human civilization. Previous studies from different fields have suggested creativity and capacity of WM have opposing characteristics possibly in terms of diffuse attention. However, despite a number of functional imaging studies on creativity, how creativity relates to brain activity during WM has never been investigated. In this functional magnetic resonance imaging (fMRI) study, we investigated this issue using an n-back WM paradigm and a psychometric measure of creativity (a divergent thinking test). A multiple regression analysis revealed that individual creativity was significantly and positively correlated with brain activity in the precuneus during the 2-back task (WM task), but not during the non-WM 0-back task. As the precuneus shows deactivation during cognitive tasks, our findings show that reduced task induced deactivation (TID) in the precuneus is associated with higher creativity measured by divergent thinking. The precuneus is included in the default mode network, which is deactivated during cognitive tasks. The magnitude of TID in the default mode network is considered to reflect the reallocation of cognitive resources from networks irrelevant to the performance of the task. Thus, our findings may indicate that individual creativity, as measured by the divergent thinking test, is related to the inefficient reallocation of attention, congruent with the idea that diffuse attention is associated with individual creativity.

  397. 383人の健常成人の縦断研究による加齢及び脳血管障害危険因子と局所脳灰白質体積減少量との相関

    瀧 靖之, 木之村 重男, 佐藤 和則, 後藤 了以, Wu Kai, 川島 隆太, 福田 寛

    日本医学放射線学会学術集会抄録集　70回　S289-S289　2011/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  398. A mini-cap for simultaneous EEG and fMRI recording in rodents Peer-reviewed

    Akira Sumiyoshi, Jorge J. Riera, Takeshi Ogawa, Ryuta Kawashima

    NEUROIMAGE　54　(3)　1951-1965　2011/02

    DOI： 10.1016/j.neuroimage.2010.09.056 　

    ISSN： 1053-8119

  399. Exploratory research on the reply to verbal irony and praise : The relationships between the reply and personality traits

    AKIMOTO Yoritaka, MIYAZAWA Shiho, SUGIURA Motoaki, KAWASHIMA Ryuta

    IEICE technical report　110　(383)　25-30　2011/01/14

    Publisher: 一般社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    In this study, we investigated how people reply to irony and praise. Results showed that principal replies to praise are modestly, thank, agree, and smile. Principal replies to irony are apology, and biter smile. Principal replies to praise from misunderstanding are apology, and biter smile. We also investigated the relationships between the reply and listener&#039;s personality traits. Results suggested that we adjust the reply and the effects of personality traits differ depending on various contexts.

  400. An in vivo MRI Template Set for Morphometry, Tissue Segmentation, and fMRI Localization in Rats. International-journal Peer-reviewed

    Pedro Antonio Valdés-Hernández, Akira Sumiyoshi, Hiroi Nonaka, Risa Haga, Eduardo Aubert-Vásquez, Takeshi Ogawa, Yasser Iturria-Medina, Jorge J Riera, Ryuta Kawashima

    Frontiers in neuroinformatics　5　26-26　2011

    DOI： 10.3389/fninf.2011.00026 　

    More details Close

    Over the last decade, several papers have focused on the construction of highly detailed mouse high field magnetic resonance image (MRI) templates via non-linear registration to unbiased reference spaces, allowing for a variety of neuroimaging applications such as robust morphometric analyses. However, work in rats has only provided medium field MRI averages based on linear registration to biased spaces with the sole purpose of approximate functional MRI (fMRI) localization. This precludes any morphometric analysis in spite of the need of exploring in detail the neuroanatomical substrates of diseases in a recent advent of rat models. In this paper we present a new in vivo rat T2 MRI template set, comprising average images of both intensity and shape, obtained via non-linear registration. Also, unlike previous rat template sets, we include white and gray matter probabilistic segmentations, expanding its use to those applications demanding prior-based tissue segmentation, e.g., statistical parametric mapping (SPM) voxel-based morphometry. We also provide a preliminary digitalization of latest Paxinos and Watson atlas for anatomical and functional interpretations within the cerebral cortex. We confirmed that, like with previous templates, forepaw and hindpaw fMRI activations can be correctly localized in the expected atlas structure. To exemplify the use of our new MRI template set, were reported the volumes of brain tissues and cortical structures and probed their relationships with ontogenetic development. Other in vivo applications in the near future can be tensor-, deformation-, or voxel-based morphometry, morphological connectivity, and diffusion tensor-based anatomical connectivity. Our template set, freely available through the SPM extension website, could be an important tool for future longitudinal and/or functional extensive preclinical studies.

  401. Increased activation of ventromedial prefrontal cortex during decision making in irritable bowel syndrome Peer-reviewed

    Aizawa Emiko, Kochiyama Takanori, Sato Yasuhiro, Morishita Joe, Sekiguchi Atsushi, Kotozaki Yuka, Miyazaki Atsushi, Kano Michiko, Kanazawa Motoyori, Sugiura Motoaki, Kawashima Ryuta, Mushiake Hajime, Fukudo Shin

    NEUROSCIENCE RESEARCH　71　E370-E371　2011

    DOI： 10.1016/j.neures.2011.07.1627 　

    ISSN： 0168-0102

  402. Correlation between baseline regional gray matter volume and global gray matter volume decline rate. Peer-reviewed

    Taki Y, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, Fukuda H

    NeuroImage　54　(2)　743-749　2011/01

    DOI： 10.1016/j.neuroimage.2010.09.071 　

    ISSN： 1053-8119

  403. Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals. Peer-reviewed

    Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Kawashima R, Fukuda H

    PloS one　6　(7)　e22734　2011

    DOI： 10.1371/journal.pone.0022734 　

  404. Residual visual function detected by visual evoked magnetic fields due to flash stimuli in minimally conscious state patients Peer-reviewed

    Kanno Akitake, Nakasato Nobukazu, Naganime Yoshihide, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　71　E77-E77　2011

    DOI： 10.1016/j.neures.2011.07.328 　

    ISSN： 0168-0102

  405. 外国語単語リーディングにおける母語の文字体系の影響:fMRI実験による検討

    横山悟, 金情浩, 内田信也, 宮本正夫, 吉本啓, 川島隆太

    日本認知科学会大会発表論文集(CD-ROM)　28th　ROMBUNNO.P2-2　2011

  406. Effects of aging on hippocampal and anterior temporal activations during successful retrieval of memory for face-name associations. Peer-reviewed

    Tsukiura T, Sekiguchi A, Yomogida Y, Nakagawa S, Shigemune Y, Kambara T, Akitsuki Y, Taki Y, Kawashima R

    Journal of cognitive neuroscience　23　(1)　200-213　2011/01

    Publisher: 1

    DOI： 10.1162/jocn.2010.21476 　

    ISSN： 0898-929X 1530-8898

    eISSN： 1530-8898

  407. Working memory training using mental calculation impacts regional gray matter of the frontal and parietal regions. Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

    PloS one　6　(8)　e23175　2011

    Publisher: 8

    DOI： 10.1371/journal.pone.0023175 　

    ISSN： 1932-6203

  408. Testing second language oral proficiency in direct and semi-direct settings: a social-cognitive neuroscience perspective. Peer-reviewed

    Jeong H, Hashizume H, Sugiura M, Sassa Y, Yokoyama S, Shiozaki S, Kawashima R

    Language Learning　61　(3)　675-699　2011

    DOI： 10.1111/j.1467-9922.2011.00635.x 　

  409. An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats. International-journal Peer-reviewed

    Takakuni Goto, Rieko Hatanaka, Takeshi Ogawa, Akira Sumiyoshi, Jorge Riera, Ryuta Kawashima

    Journal of neurophysiology　104　(6)　3388-412　2010/12

    DOI： 10.1152/jn.00122.2010 　

    More details Close

    Microelectrode arrays used to record local field potentials from the brain are being built with increasingly more spatial resolution, ranging from the initially developed laminar arrays to those with planar and three-dimensional (3D) formats. In parallel with such development in recording techniques, current source density (CSD) analyses have recently been expanded up to the continuous-3D form. Unfortunately, the effect of the conductivity profile on the CSD analysis performed with contemporary microelectrode arrays has not yet been evaluated and most of the studies assumed it was homogeneous and isotropic. In this study, we measured the conductivity profile in the somatosensory barrel cortex of Wistar rats. To that end, we combined multisite electrophysiological data recorded with a homemade assembly of silicon-based probes and a nonlinear least-squares algorithm that implicitly assumed that the cerebral cortex of rodents could be locally approximated as a layered anisotropic spherical volume conductor. The eccentricity of the six cortical layers in the somatosensory barrel cortex was evaluated from postmortem histological images. We provided evidence for the local spherical character of the entire barrels field, with concentric cortical layers. We found significant laminar dependencies in the conductivity values with radial/tangential anisotropies. These results were in agreement with the layer-dependent orientations of myelinated axons, but hardly related to densities of cells. Finally, we demonstrated through simulations that ignoring the real conductivity profile in the somatosensory barrel cortex of rats caused considerable errors in the CSD reconstruction, with pronounced effects on the continuous-3D form and charge-unbalanced CSD. We concluded that the conductivity profile must be included in future developments of CSD analysis, especially for rodents.

  410. Breakfast staple types affect brain gray matter volume and cognitive function in healthy children International-journal Peer-reviewed

    Taki Y, Hashizume H, Thyreau B, Sassa Y, Takeuchi Y, Asano M, Asano K, Kotozaki Y, Nouchi R, Wu K, Fukuda H, Kawashima R

    PloS one　5　(12)　e15213　2010/12

    DOI： 10.1371/journal.pone.0015213 　

    More details Close

    Childhood diet is important for brain development. Furthermore, the quality of breakfast is thought to affect the cognitive functioning of well-nourished children. To analyze the relationship among breakfast staple type, gray matter volume, and intelligence quotient (IQ) in 290 healthy children, we used magnetic resonance images and applied voxel-based morphometry. We divided subjects into rice, bread, and both groups according to their breakfast staple. We showed that the rice group had a significantly larger gray matter ratio (gray matter volume percentage divided by intracranial volume) and significantly larger regional gray matter volumes of several regions, including the left superior temporal gyrus. The bread group had significantly larger regional gray and white matter volumes of several regions, including the right frontoparietal region. The perceptual organization index (POI; IQ subcomponent) of the rice group was significantly higher than that of the bread group. All analyses were adjusted for age, gender, intracranial volume, socioeconomic status, average weekly frequency of having breakfast, and number of side dishes eaten for breakfast. Although several factors may have affected the results, one possible mechanism underlying the difference between the bread and the rice groups may be the difference in the glycemic index (GI) of these two substances; foods with a low GI are associated with less blood-glucose fluctuation than are those with a high GI. Our study suggests that breakfast staple type affects brain gray and white matter volumes and cognitive function in healthy children; therefore, a diet of optimal nutrition is important for brain maturation during childhood and adolescence.

  411. 脳波・筋電図の臨床 遷延性意識障害例の聴性定常状態誘発磁界 Peer-reviewed

    菅野 彰剛, 中里, 信和, 川瀬, 哲明, 長嶺, 義秀, 川島 隆太

    臨床脳波　52　(12)　719-723　2010/12

    Publisher:

    ISSN： 0485-1447

  412. Right frontopolar cortex activity correlates with reliability of retrospective rating of confidence in short-term recognition memory performance International-journal Peer-reviewed

    O. Yokoyama, N. Miura, J. Watanabe, A. Takemoto, S. Uchida, M. Sugiura, K. Horie, S. Sato, R. Kawashima, K. Nakamura

    Neuroscience Research　68　(3)　199-206　2010/11

    DOI： 10.1016/j.neures.2010.07.2041 　

    ISSN： 0168-0102

    More details Close

    Human memory systems contain self-monitoring mechanisms for evaluating their progress. People can change their learning strategy on the basis of confidence in their performance at that time. However, it has not been fully understood how the brain is engaged in reliable rating of confidence in past recognition memory performance. We measured the brain activity by fMRI while healthy subjects performed a visual short-term recognition memory test and then rated their confidence in their answers as high, middle, or low. As shown previously, their behavioral performance in the confidence rating widely varied; some showed a positive confidence-recognition correlation (i.e., "rate reliably") while others did not. Among brain regions showing greater activity during rating their confidence relative to during a control, non-metamemory task (discriminating brightness of words), only a posterior-dorsal part of the right frontopolar cortex exhibited higher activity as the confidence level better correlated with actual recognition memory performance. These results suggest that activation in the right frontopolar cortex is key to a reliable, retrospective rating of confidence in short-term recognition memory performance.

  413. Aging and decision making under uncertainty: Behavioral and neural evidence for the preservation of decision making in the absence of learning in old age Peer-reviewed

    S. M. Hadi Hosseini, Maryam Rostami, Yukihito Yomogida, Makoto Takahashi, Takashi Tsukiura, Ryuta Kawashima

    NEUROIMAGE　52　(4)　1514-1520　2010/10

    DOI： 10.1016/j.neuroimage.2010.05.008 　

    ISSN： 1053-8119

  414. Dissociable roles of the anterior temporal regions in successful encoding of memory for person identity information. Peer-reviewed

    Tsukiura T, Mano Y, Sekiguchi A, Yomogida Y, Hoshi K, Kambara T, Takeuchi H, Sugiura M, Kawashima R

    Journal of cognitive neuroscience　22　(10)　2226-2237　2010/10

    Publisher: 10

    DOI： 10.1162/jocn.2009.21349 　

    ISSN： 0898-929X 1530-8898

    eISSN： 1530-8898

  415. Developmental change of brain activation during sentence comprehension

    YOKOYAMA SATORU, TAKI YASUYUKI, HASHIZUME HIROSHI, NOZAWA TAKAYUKI, TAKAHASHI KEI, KAWASHIMA RYUTA

    電子情報通信学会技術研究報告　110　(163(TL2010 11-29))　19-24　2010/07/29

    Publisher: 社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    Brain changes morphologically and functionally as one grows. However, it is unclear how the change of functional brain activation during sentence comprehension occurs on development. We measured functional brain images during sentence comprehension tasks of 114 juveniles from six to eighteen years old (62 girls and 52 boys) by using functional magnetic resonance imaging (fMRI). We found that the brain activation of several right hemispheric brain regions negatively correlates with age for only boys. Also, the developmental change occurs linearly.

  416. Regional gray matter volume of dopaminergic system associate with creativity: evidence from voxel-based morphometry. Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

    NeuroImage　51　(2)　578-585　2010/06

    Publisher: 2

    DOI： 10.1016/j.neuroimage.2010.02.078 　

    ISSN： 1053-8119

  417. How Can Brain Learn to Control a Nonholonomic System Peer-reviewed

    Noriyasu Homma, Shinpei Kato, Takakuni Goto, Ivo Bukovsky, Ryuta Kawashima, Makoto Yoshizawa

    Journal of Robotics　2010　(919306)　1-7　2010/05

  418. 【循環制御の基礎の進歩】 循環制御機能をコントロールすることができる乗用車の可能性の展開 Peer-reviewed

    山家智之, 金野敏, 白石泰之, 劉紅煎, 川島隆太, 阿部恒之, 杉田典大, 吉沢誠, 関隆志

    循環制御　30　(3)　127-141　2010/05

  419. White matter structures associated with creativity: evidence from diffusion tensor imaging. Peer-reviewed

    Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R

    NeuroImage　51　(1)　11-18　2010/05

    Publisher: 1

    DOI： 10.1016/j.neuroimage.2010.02.035 　

    ISSN： 1053-8119

  420. Learning second language vocabulary: neural dissociation of situation-based learning and text-based learning. Peer-reviewed

    Jeong H, Sugiura M, Sassa Y, Wakusawa K, Horie K, Sato S, Kawashima R

    NeuroImage　50　(2)　802-809　2010/04

    Publisher: 2

    DOI： 10.1016/j.neuroimage.2009.12.038 　

    ISSN： 1053-8119

  421. ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化 健常日本人脳MR画像データベースを用いた画像医学的研究

    福田 寛, 滝 靖之, Wu Kai, 木之村 重男, 佐藤 和則, 井上 健太郎, 後藤 了以, 岡田 賢, 川島 隆太

    ナノ医工学年報　3　(1)　93-102　2010/03

    Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」

    ISSN： 1882-4692

  422. Concurrent observations of astrocytic Ca2+ activity and multisite extracellular potentials from an intact cerebral cortex Peer-reviewed

    Jorge Riera, Takeshi Ogawa, Rieko Hatanaka, Takakuni Goto, Akira Sumiyoshi, Herve Enjieu Kadji, Sakura Nakauchi, Ryuta Kawashima

    JOURNAL OF BIOPHOTONICS　3　(3)　147-160　2010/03

    DOI： 10.1002/jbio.200910036 　

    ISSN： 1864-063X

  423. The neural basis of agency: an fMRI study. Peer-reviewed

    Yomogida Y, Sugiura M, Sassa Y, Wakusawa K, Sekiguchi A, Fukushima A, Takeuchi H, Horie K, Sato S, Kawashima R

    NeuroImage　50　(1)　198-207　2010/03

    Publisher: 1

    DOI： 10.1016/j.neuroimage.2009.12.054 　

    ISSN： 1053-8119

  424. Training of working memory impacts structural connectivity. Peer-reviewed

    Takeuchi H, Sekiguchi A, Taki Y, Yokoyama S, Yomogida Y, Komuro N, Yamanouchi T, Suzuki S, Kawashima R

    The Journal of neuroscience : the official journal of the Society for Neuroscience　30　(9)　3297-3303　2010/03

    Publisher: 9

    DOI： 10.1523/JNEUROSCI.4611-09.2010 　

    ISSN： 1529-2401 0270-6474

  425. 診断治療機能を保持する自動車の可能性 Peer-reviewed

    山家智之, 金野敏, 白石泰之, 川島隆太, 阿部恒之, 杉田典大, 吉沢誠, 関隆志

    日本臨床生理学会雑誌　40　(1)　5-14　2010/02

  426. Pitfalls in the dipolar model of the neocortical EEG sources

    Jorge Riera, Takeshi Ogawa, Takakuni Goto, Akira Sumiyoshi, Hiroi Nonaka, Alan Evans, Ryuta Kawashima

    APSIPA ASC 2010 - Asia-Pacific Signal and Information Processing Association Annual Summit and Conference　964-968　2010

  427. Age-related differences in brain activity during successful encoding of memory for person identity information Peer-reviewed

    Takashi Tsukiura, Yayoi Shigemune, Toshimune Kambara, Atsushi Sekiguchi, Yukihito Yomogida, Seishu Nakagawa, Yuko Akitsuki, Yasuyuki Taki, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　68　E300-E300　2010

    DOI： 10.1016/j.neures.2010.07.1334 　

    ISSN： 0168-0102

  428. Age-dependency in brain activation involved with imitation of unfamiliar foreign language sound: an fMRI study Peer-reviewed

    Hashizume Hiroshi, Taki Yasuyuki, Sassa Yuko, Asano Michiko, Asano Kohei, Takeuchi Hikaru, Jeong Hyeonjeong, Sugiura Motoaki, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　68　E300-E301　2010

    DOI： 10.1016/j.neures.2010.07.1335 　

    ISSN： 0168-0102

  429. Functional anatomy of visuosocial processing in temporo-parietal region Peer-reviewed

    Sugiura Motoaki, Yomogida Yukihito, Mano Yoko, Sassa Yuko, Kambara Toshimune, Sekiguchi Atsushi, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　68　E415　2010

    DOI： 10.1016/j.neures.2010.07.1840 　

    ISSN： 0168-0102

  430. Effects of working memory training on cognitive functions and neural systems. Peer-reviewed

    Takeuchi H, Taki Y, Kawashima R

    Reviews in the neurosciences　21　(6)　427-449　2010

    ISSN： 0334-1763

  431. Effect of motion smoothness on brain activity while observing a dance: An fmri study using a humanoid robot International-journal Peer-reviewed

    N. Miura, M. Sugiura, M. Takahashi, Y. Sassa, A. Miyamoto, S. Sato, K. Horie, K. Nakamura, R. Kawashima

    Social Neuroscience　5　(1)　40-58　2010

    DOI： 10.1080/17470910903083256 　

    ISSN： 1747-0919

    More details Close

    Motion smoothness is critical in transmitting implicit information of body action, such as aesthetic qualities in dance performances. We expected that the perception of motion smoothness would be characterized by great intersubject variability deriving from differences in personal backgrounds and attitudes toward expressive body actions. We used functional magnetic resonance imaging and a humanoid robot to investigate the effects of the motion smoothness of expressive body actions and the intersubject variability due to personal attitudes on perceptions during dance observation. The effect of motion smoothness was analyzed by both conventional subtraction analysis and functional connectivity analyses that detect cortical networks reflecting intersubject variability. The results showed that the cortical networks of motion- and body-sensitive visual areas showed increases in activity in areas corresponding with motion smoothness, but the intersubject variability of personal attitudes toward art did not influence these active areas. In contrast, activation of cortical networks, including the parieto-frontal network, has large intersubject variability, and this variability is associated with personal attitudes about the consciousness of art. Thus, our results suggest that activity in the cortical network involved in understanding action is influenced by personal attitudes about the consciousness of art during observations of expressive body actions.

  432. Human brain activities related to manual control of a nonholonomic system Peer-reviewed

    Noriyasu Homma, Shinpei Kato, Takakuni Goto, Masao Sasaki, Norihiro Sugita, Makoto Yoshizawa, Yukihito Yomogida, Yuko Sassa, Motoaki Sugiura, Jorge Reira, Ryuta Kawashima

    International Journal of Advanced Computer Engineering　2　(2)　129-133　2009/12

  433. Analyzing control-display movement compatibility: A neuroimaging study Peer-reviewed

    S. M.Hadi Hosseini, Maryam Rostami, Makoto Takahashi, Naoki Miura, Motoaki Sugiura, Ryuta Kawashima

    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)　5639 LNAI　187-196　2009/12/01

    DOI： 10.1007/978-3-642-02728-4_20 　

    ISSN： 0302-9743

  434. Assessment of English learners' reading skills by utilizing functional brain imaging

    YOKOYAMA Satoru, Susila I Putu, OSAWA Takeshi, KAWASHIMA Ryuta

    Technical report of IEICE. Thought and language　109　(297)　57-62　2009/11/14

    Publisher: 社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    So far, in order to assess learner&#039;s foreign language proficiency, the output result after language processing from learners has been used. The current research aims at developing assessment system of foreign language proficiency by using brain response during language tests. In this paper, we report the results investigating whether the brain response data can predict learners&#039; behavioral performance of language tests.

  435. Neural correlates of processing situational relationships between a part and the whole: an fMRI study. Peer-reviewed

    Wakusawa K, Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, Yokoyama H, Tsuchiya S, Kawashima R

    NeuroImage　48　(2)　486-496　2009/11

    Publisher: 2

    DOI： 10.1016/j.neuroimage.2009.06.024 　

    ISSN： 1053-8119

  436. Anatomical Segregation of Representations of Personally Familiar and Famous People in the Temporal and Parietal Cortices Peer-reviewed

    Motoaki Sugiura, Yuko Sassa, Jobu Watanabe, Yuko Akitsuki, Yasuhiro Maeda, Yoshihiko Matsue, Ryuta Kawashima

    JOURNAL OF COGNITIVE NEUROSCIENCE　21　(10)　1855-1868　2009/10

    DOI： 10.1162/jocn.2008.21150 　

    ISSN： 0898-929X

  437. Cortical areas related to performance of WAIS Digit Symbol Test: a functional imaging study. Peer-reviewed

    Usui Nobuo, Haji Tomoki, Maruyama Masakazu, Katsuyama Narumi, Uchida Shinya, Hozawa Atsushi, Omori Kahoru, Tsuji Ichiro, Kawashima Ryuta, Taira Masato

    Neurosci Lett　463　(1)　1-5　2009/09/29

    DOI： 10.1016/j.neulet.2009.07.048 　

  438. Left Middle Temporal Deactivation Caused by Insufficient Second Language Word Comprehension by Chinese-Japanese Bilinguals Peer-reviewed

    Satoru Yokoyama, Tadao Miyamoto, Jungho Kim, Noriaki Yusa, Kei Yoshimoto, Ryuta Kawashima

    Journal of Neurolinguistics　22　(5)　495-513　2009/09

    DOI： 10.1016/j.jneuroling.2009.04.002 　

  439. Neural activity in the human brain signals logical rule identification International-journal Peer-reviewed

    Kaori Tachibana, Kyoko Suzuki, Etsuro Mori, Naoki Miura, Ryuta Kawashima, Kaoru Horie, Shigeru Sato, Jun Tanji, Hajime Mushiake

    Journal of Neurophysiology　102　(3)　1526-1537　2009/09/01

    DOI： 10.1152/jn.90659.2008 　

    ISSN： 0022-3077

  440. Extraction of situational meaning by integrating multiple meanings in a complex environment: a functional MRI study. Peer-reviewed

    Sugiura M, Wakusawa K, Sekiguchi A, Sassa Y, Jeong H, Horie K, Sato S, Kawashima R

    Human brain mapping　30　(8)　2676-2688　2009/08

    Publisher: 8

    DOI： 10.1002/hbm.20699 　

    ISSN： 1065-9471

  441. Neural bases of goal-directed implicit learning Peer-reviewed

    Maryam Rostami, S.M.Hadi Hosseini, Makoto Takahashi, Motoaki Sugiura, Ryuta Kawashima

    NeuroImage　48　303-310　2009/06

    DOI： 10.1016/j.neuroimage.2009.06.007 　

  442. A Relationship between Task Difficulty and Interface Design during Meter Inspection : A functional Magnetic Resonance Imaging Study Peer-reviewed

    MIURA Naoki, TAKAHASHI Makoto, KAWASHIMA Ryuta, KITAMURA Masaharu, WAKABAYASHI Toshio

    Human interface　11　(2)　193-202　2009/05/25

    Publisher: ヒューマンインタフェース学会

    ISSN： 1344-7262

  443. Learning Effect of L2 Words in Non-Fluent Second Language Learners: An FMRI Study Peer-reviewed

    Satoru Yokoyama, Tadao Miyamoto, Jungho Kim, Shin-ya Uchida, Kei Yoshimoto, Ryuta Kawashima

    Second Languages: Teaching, Learning and Assessment, Nova Science Publishers　147-156　2009/04

  444. Neural basis of sentence processing in which incoming words form a sentence Peer-reviewed

    Ikuta Naho, Sugiura Motoaki, Inoue Kentaro, Sato Shigeru, Horie Kaoru, Kawashima Ryuta

    NEUROREPORT　20　(5)　531-535　2009/03/25

    DOI： 10.1097/WNR.0b013e3283294061 　

    ISSN： 0959-4965

  445. ヒト脳の正常加齢およびその危険因子の解明 健常日本人脳MR画像データベースを用いた画像医学的研究

    福田 寛, 滝 靖之, Wu Kai, 木之村 重男, 佐藤 和則, 井上 健太郎, 後藤 了以, 岡田 賢, 川島 隆太

    ナノ医工学年報　2　(1)　89-97　2009/03

    Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」

    ISSN： 1882-4692

  446. Scrambling effects on the processing of Japanese sentences: An fMRI study Peer-reviewed

    Kim, Jungho, Masatoshi Koizumi, Naho Ikuta, Yuichiro Fukumitsu, Naoki Kimura, Kazuki Iwata, Jobu Watanabe, Satoru Yokoyama, Shigeru Sato, Kaoru Horie, Ryuta Kawashima

    Journal of Neurolinguistics　22　151-166　2009/03

    DOI： 10.1016/j.jneuroling.2008.07.005 　

  447. 年齢相応の脳発達とは?

    瀧 靖之, 橋爪 寛, 佐々 祐子, 木之村 重男, 後藤 了以, 佐藤 和則, 福田 寛, 川島 隆太

    日本医学放射線学会学術集会抄録集　68回　S274-S274　2009/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  448. Normal Brain Aging and its Risk Factors - Analysis of Brain Magnetic Resonance Image (MRI) Database of Healthy Japanese Subjects Peer-reviewed

    H. Fukuda, Y. Taki, K. Sato, S. Kinomura, R. Goteau, R. Kawashima

    13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2228-+　2009

    ISSN： 1680-0737

  449. Social interaction and concern for others in episodic memory: an fMRI study Peer-reviewed

    Yoko Mano, Motoaki Sugiura, Takashi Tsukiura, Yukihito Yomogida, Hyeonjeong Jeong, Atsushi Sekiguchi, Yuko Akitsuki, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　65　S244-S244　2009

    DOI： 10.1016/j.neures.2009.09.1383 　

    ISSN： 0168-0102

  450. A NIRS-based Brain-Computer Interface System during Motor Imagery: System Development and Online Feedback Training

    Shin'ichiro Kanoh, Yu-mi Murayama, Ko-ichiro Miyamoto, Tatsuo Yoshinobu, Ryuta Kawashima

    2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20　594-+　2009

    DOI： 10.1109/IEMBS.2009.5333710 　

    ISSN： 1557-170X

  451. Neural basis of episode context: an fMRI study Peer-reviewed

    Sugiura Motoaki, Yomogida Yukihito, Kambara Toshimune, Mano Yoko, Sekiguchi Atsushi, Tsukiura Takashi, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　65　S236　2009

    DOI： 10.1016/j.neures.2009.09.1330 　

    ISSN： 0168-0102

  452. Neuro-physiological evidence of linguistic empathy processing in the human brain: a functional magnetic resonance imaging study. Peer-reviewed

    Satoru Yokoyama, Kei Yoshimoto, Tadao Miyamoto, Ryuta Kawashima

    Journal of Neurolinguistics　2009

    DOI： 10.1016/j.jneuroling.2009.07.002 　

  453. Somatotopical relationships between cortical activity and reflex areas in reflexology: A functional magnetic resonance imaging study Peer-reviewed

    Tomomi Nakamaru, Naoki Miura, Ai Fukushima, Ryuta Kawashima

    Neuroscience Letters　448　(1)　6-9　2008/12/19

    Publisher: Elsevier Ireland Ltd.

    DOI： 10.1016/j.neulet.2008.10.022 　

    ISSN： 0304-3940

  454. Human Cortical Anatomical Networks Assessed by Structural MRI Peer-reviewed

    A. C. Evans, J. M. Lee, S. I. Kim, H. Fukuda, R. Kawashima, Y. He, T. Jiang, J. S. Kim, Z. Chen, K. Im, O. Lyttelton, J. Lerch, V. Singh, K. Sato, Y. Taki, R. Goto, S. Kinomura, K. Mok, J. K. Lee, U. Yoon

    BRAIN IMAGING AND BEHAVIOR　2　(4)　289-299　2008/12

    DOI： 10.1007/s11682-008-9034-3 　

    ISSN： 1931-7557

    eISSN： 1931-7565

  455. Neural substrates of the Topology Test to measure fluid reasoning: An fMRI study Peer-reviewed

    Hiromi Masuinaga, Ryuta Kawashima, John L. Horn, Yuko Sassa, Atsushi Sekiguchi

    INTELLIGENCE　36　(6)　607-615　2008/11

    DOI： 10.1016/j.intell.2008.01.006 　

    ISSN： 0160-2896

  456. F-MRI analysis of the human brain activities during manual control of a nonholonomic system Peer-reviewed

    Shinpei Kato, Takakuni Goto, Noriyasu Homma, Makoto Yoshizawa, Yukihito Yomogida, Yuko Sassa, Motoaki Sugiura, Jorge Riera, Ryuta Kawashima

    Proc. SICE 2008　1977-1980　2008/08

  457. Neural mechanism of information retrieval unique to sentence comprehension

    TAKAHASHI Kei, YOKOYAMA Satoru, KAMBARA Toshimune, YOSHIMOTO Kei, KAWASHIMA Ryuta

    Technical report of IEICE. Thought and language　108　(184)　11-15　2008/08/01

    Publisher: 社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    The aim of this study was to clarify the neural mechanism of information retrieval (IR) related to human sentence comprehension using fMRI. Two sets of letters, words, or sentences were presented visually. In a letter or word condition, letters or a word were presented after the presentation of two sets of stimuli, and subjects were asked to judge whether presented letters or word were included in former or latter set. In a sentences condition, participants were asked to read ill-formed coordination sentences and asked to judge which conjunct included inappropriate constituent. The results ...

  458. Neuronal relationship among sub-processes on sentence comprehension in the human brain

    YOKOYAMA Satoru, KAWASHIMA Ryuta

    Technical report of IEICE. Thought and language　108　(184)　5-10　2008/08/01

    Publisher: 社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    In order to comprehend a sentence, we need several sub-processes. For example, it is necessary to store phonological information tentatively to recognize a word from phonological input. Similarly, it is also necessary to store lexico-semantic information of words to compute a sentence-structure from these words. In this paper, we discuss how sub-processes for sentence comprehension interact with each other based on effective connectivity data of fMRI.

  459. Face-specific and domain-general characteristics of cortical responses during self-recognition Peer-reviewed

    Motoaki Sugiura, Yuko Sassa, Hyeonjeong Jeong, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

    NEUROIMAGE　42　(1)　414-422　2008/08

    DOI： 10.1016/j.neuroimage.2008.03.054 　

    ISSN： 1053-8119

  460. A Decay Effect in Real-time Sentence Processing Peer-reviewed

    Kei Takahashi, Satoru Yokoyama, Toshimune Kambara, Kei Yoshimoto, Ryuta Kawashima

    Proceedings of the 6th International Conference of Cognitive Science　218-221　2008/07

  461. Brain Activation in Consecutive Interpreting among University Students with High English Proficiency Peer-reviewed

    TATSUMI KEIKO, DEGUCHI HIROSHI, NAGAO HIROMI, SUGIURA MOTOAKI, JEONG HYEONJEONG, IKUTA NAHO, HASHIZUME HIROSHI, MATSUNAWA JUNKO, KAWASHIMA RYUTA

    神戸女学院大学論集　55　(1)　89-104　2008/06

    Publisher: Kobe College

    DOI： 10.18878/00001856 　

    ISSN： 0389-1658

    More details Close

    One of human-being specific activities, interpreting (oral translation), has been adopted as a popular method to enhance second language acquisition lately. The question, however, how interpreting is executed in human brains, remains largely unknown. In this paper, we present our fMRI (functional Magnetic Resonance Imaging) experimental results to investigate how cerebral cortices are activated when subjects are engaged in interpreting exercises. Twenty-one healthy, right-handed university student subjects participated in this study. We directly compared English to Japanese consecutive interpreting (EJ) to Japanese to English consecutive interpreting (JE) using subtraction method, as well as with sentence reconstruction tasks in Japanese (JJ) and English (EE), and with resting condition (Rest, or baseline). The direct subtraction analysis between EJ and JE left only a limited area: left superior temporal gyrus remained. In JE minus EJ (masked by EJ-Rest: P<0.05image), right and left precentral gyri, left thalamus, left and right superior temporal gyri, and left middle temporal gyrus are left, suggesting that JE recruited more extensive regions in comparison with EJ, despite that all sources of sentence recorded and used as stimuli were constructed to be at the same level of difficulty, either directly taken from MEXT (Ministry of Education, Culture, Sports, Science and Technology) -authorized popular textbooks used in Japanese public junior high schools, or translation of such sources. The conditions EJ, EE, and JJ showed very similar patterns of cortical activation, indicating that the conditions recruited similar brain regions: left and right superior temporal gyri, mainly left middle temporal gyrus,, left inferior frontal gyrus (opercular part and triangular part), left temporal lobe's lateral surface, and mainly left supplementary motor areas. EJ and JE commonly activated Inferior frontal gyri (opercular part and triangular part) and supplementary motor areas in both hemispheres. Kawashima (2004) reports that even a different-activity-related cortical activation serves as a preparatory activity for the individuals' following activity and enhances learning or delays development of dementia in older subjects. From the results, we infer that EE and JJ sentence reconstruction exercises that activated similar regions to those activated in consecutive interpreting might fit the purpose of consecutive interpreting training preparation.

  462. Electromagnetic source imaging: Backus-Gilbert resolution spread function-constrained and functional MRI-guided spatial filtering Peer-reviewed

    Xiaohong Wan, Atsushi Sekiguchi, Satoru Yokoyama, Jorge Riera, Ryuta Kawashima

    HUMAN BRAIN MAPPING　29　(6)　627-643　2008/06

    DOI： 10.1002/hbm.20424 　

    ISSN： 1065-9471

  463. Decrease in glucose metabolism in frontal cortex associated with deterioration of microstructure of corpus callosum measured by diffusion tensor imaging in healthy elderly Peer-reviewed

    Kentaro Inoue, Hiroshi Ito, Shinya Uchida, Yasuyuki Taki, Shigeo Kinomura, Ichiro Tsuji, Shigeru Sato, Kaoru Horie, Ryuta Kawashima, Masatoshi Ito, Hiroshi Fukuda

    HUMAN BRAIN MAPPING　29　(4)　375-384　2008/04

    DOI： 10.1002/hbm.20394 　

    ISSN： 1065-9471

  464. Acceptability and Word Order in Sentence Processing Peer-reviewed

    Kei Takahashi, Satoru Yokoyama, Kei Yoshimoto, Ryuta Kawashima

    言語処理学会第14回年次大会発表論文集　2008/03

  465. Reading and solving arithmetic problems improves cognitive functions of normal aged people: a randomized controlled study Peer-reviewed

    Shinya Uchida, Ryuta Kawashima

    AGE　30　(1)　21-29　2008/03

    DOI： 10.1007/s11357-007-9044-x 　

    ISSN： 0161-9152

  466. 加齢による灰白質体積の減少は男性が女性よりも早い 382人の脳MRI解析による縦断研究

    瀧 靖之, 木之村 重男, 後藤 了以, 佐藤 和則, 川島 隆太, 福田 寛

    日本医学放射線学会学術集会抄録集　67回　S245-S245　2008/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  467. Activity of the human lateral prefrontal cortex is related to psychosocial maturity&ndash;An fMRI study of understanding others' decision-making

    Tachibana Yoshiyuki, Sugiura Motoaki, Sassa Yuko, Kawashima Ryuta

    Proceedings of Annual Meeting of the Physiological Society of Japan　2008　(0)　30-30　2008

    Publisher: 日本生理学会

    More details Close

    The purpose of this study was to identify the neural correlates of psychosocial maturity during understanding others from the viewpoint of self. In psychology, ego identity is one of the most famous theories for psychosocial maturity. Those who have established ego identity have a definite purpose for one&#039;s life and an ability of goal directed behavior. We assumed that such a psychosocial maturity is related to the ability to distinguish others from self when one understands the others. We used an fMRI technique to identify cortical regions where activity during understanding others&#039; decision-making is correlated with personality maturity. We measured subjects&#039; personality maturity using the Rasmussen&#039;s Ego Identity Scale. There were three conditions, S, F and G which were perspective taking conditions for inferring self, best friend and people in general&#039;s decision-making, respectively. Differential activation of both the contrasts F-S and G-S was significantly correlated with the ego identity scale in the left lateral prefrontal cortex (LPFC). The results indicate that the activity of the left LPFC is related to psychosocial maturity when understanding others from the viewpoint of self. We suggest that psychosocial maturity is related to the development of the executive function which is supported by the left LPFC. &lt;b&gt;[J Physiol Sci. 2008;58 Suppl:S30]&lt;/b&gt;

  468. How intellectual excitement enhances encoding of novel information? Peer-reviewed

    Ai Fukushima, Sugiura Motoaki, Sassa Yuko, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　61　S115　2008

    ISSN： 0168-0102

  469. Cortical mechanism of knowledge-based monitoring and intention-based monitoring Peer-reviewed

    Yomogida Yukihito, Sugiura Motoaki, Sasse Yuko, Wakusawa Keisuke, Sekiguchi Atsushi, Fukushima At, Takeuchi Hikaru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　61　S118　2008

    ISSN： 0168-0102

  470. Imitation of unfamiliar foreign language sound: An fMRI study Peer-reviewed

    Hashizume Hiroshi, Jeong Hyeonjeong, Ikuta Naho, Sugiura Motoaki, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　61　S199　2008

    ISSN： 0168-0102

  471. Roles of the medial orbitofrontal cortices (mOFC) and the nucleus accumbens (NAcc) in reward processing under passive situation Peer-reviewed

    Sekiguchi Atsushi, Sugiura Motoaki, Ikuta Naha, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　61　S280　2008

    ISSN： 0168-0102

  472. Relationship between body mass index and gray matter volume in 1,428 healthy individuals Peer-reviewed

    Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Kentaro Inoue, Ryoi Goto, Ken Okada, Shinya Uchida, Ryuta Kawashima, Hiroshi Fukuda

    OBESITY　16　(1)　119-124　2008/01

    DOI： 10.1038/oby.2007.4 　

    ISSN： 1930-7381

  473. An advantage of bipedal humanoid robot on the empathy generation: a neuroimaging study Peer-reviewed

    Naoki Miura, Motoaki Sugiura, Makoto Takahashi, Tomohisa Moridaira, Atsushi Miyamoto, Yoshihiro Kuroki, Ryuta Kawashima

    2008 IEEE/RSJ INTERNATIONAL CONFERENCE ON ROBOTS AND INTELLIGENT SYSTEMS, VOLS 1-3, CONFERENCE PROCEEDINGS　2465-+　2008

    DOI： 10.1109/IROS.2008.4650603 　

  474. Processing of Anomalous Sentences in Japanese : An fMRI Study

    Yuko Sassa, Motoaki Sugiura, Yoshihiko Matsue, Yuko Akitsuki, Yasuhiro Maeda, Ryuta Kawashima, Jobu Watanabe

    Journal of Cognitive Science　8　(2)　153-170　2007/12

    Publisher: Institute for Cognitive Science

    DOI： 10.17791/jcs.2007.8.2.153 　

    ISSN： 1598-2327

  475. Assessment of Language Proficiency in Foreign Language Learning based on Functional Brain Imaging Data

    YOKOYAMA Satoru, YOSHIMOTO Kei, KAWASHIMA Ryuta

    Technical report of IEICE. Thought and language　107　(323)　37-40　2007/11/09

    Publisher: 社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    In this paper, we propose that functional brain imaging data can be applied to the assessment of language proficiency in foreign language learning. Functional brain imaging techniques can visualize how the human brain works during a cognitive task. Hence, by using such functional brain imaging data, we can assess whether a learner can properly comprehend a foreign language. Furthermore, such a database may enable us to apply the assessment of whether a new language education method has effective or not.

  476. Comprehension of implicit meanings in social situations involving irony: a functional MRI study. Peer-reviewed

    Wakusawa K, Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, Yokoyama H, Tsuchiya S, Inuma K, Kawashima R

    NeuroImage　37　(4)　1417-1426　2007/10/01

    DOI： 10.1016/j.neuroimage.2007.06.013 　

    ISSN： 1053-8119

  477. Body Mass Indexと全脳及び局所灰白質量との相関 1428人の脳MR画像を用いたvoxel-based morphometryによる解析

    瀧 靖之, 木之村 重男, 佐藤 和則, 後藤 了以, 井上 健太郎, 岡田 賢, 福田 寛, 川島 隆太

    日本医学放射線学会秋季臨床大会抄録集　43回　S459-S459　2007/09

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  478. Cortical mechanism of communicative speech production. Peer-reviewed

    Sassa Y, Sugiura M, Jeong H, Horie K, Sato S, Kawashima R

    NeuroImage　37　985-992　2007/09

    Publisher: 3

    DOI： 10.1016/j.neuroimage.2007.05.059 　

    ISSN： 1053-8119

  479. Working memory system as a sentence processor in the human brain Peer-reviewed

    Satoru Yokoyama, Kei Takahashi, Toshimune Kambara, Tadao Miyamoto, Kei Yoshimoto, Ryuta Kawashima

    電子情報通信学会 思考と言語研究会 (TL)７月研究会　2007/07

  480. Cross-linguistic influence on brain activation during second language processing: An fMRI study Peer-reviewed

    Hyeonjeong Jeong, Motoaki Sugiura, Yuko Sassa, Satoru Yokoyama, Kaoru Horie, Shigeru Sato, Masato Taira, Ryuta Kawashima

    BILINGUALISM-LANGUAGE AND COGNITION　10　(2)　175-187　2007/07

    DOI： 10.1017/S1366728907002921 　

    ISSN： 1366-7289

  481. Thematic Difficulty Causes Processing Cost for Sentence Comprehension Peer-reviewed

    Satoru Yokoyama, Masatoshi Koizumi, Jungho Kim, Noriaki Yusa, Kei Yoshimoto, Ryuta Kawashima

    Proceedings of the European Cognitive Science Conference 2007　915　2007/05

  482. Cognitive rehabilitation - The learning therapy for the senile dementia Peer-reviewed

    Atsushi Sekiguchi, Ryuta Kawashima

    Brain and Nerve　59　(4)　357-365　2007/04

    ISSN： 0006-8969

  483. [Cognitive rehabilitation--the learning therapy for the senile dementia]. Peer-reviewed

    Sekiguchi A, Kawashima R

    Brain and nerve = Shinkei kenkyu no shinpo　59　(4)　357-365　2007/04

    Publisher: 4

    ISSN： 1881-6096

  484. Is Broca's area involved in the processing of passive sentences? An event-related fMRI study. Peer-reviewed

    Yokoyama S, Watanabe J, Iwata K, Ikuta N, Haji T, Usui N, Taira M, Miyamoto T, Nakamura W, Sato S, Horie K, Kawashima R

    Neuropsychologia　45　989-996　2007/03

    Publisher: 5

    DOI： 10.1016/j.neuropsychologia.2006.09.003 　

    ISSN： 0028-3932

  485. Effect of syntactic similarity on cortical activation during second language processing: a comparison of English and Japanese among native Korean trilinguals. Peer-reviewed

    Jeong H, Sugiura M, Sassa Y, Haji T, Usui N, Taira M, Horie K, Sato S, Kawashima R

    Human brain mapping　28　(3)　194-204　2007/03

    DOI： 10.1002/hbm.20269 　

    ISSN： 1065-9471

  486. 加齢に伴う脳灰白質体積の経時変化 健常被験者の脳MRI解析による8年間の縦断研究(第一報)

    瀧 靖之, 木之村 重男, 後藤 了以, 佐藤 和則, 川島 隆太, 福田 寛

    日本医学放射線学会学術集会抄録集　66回　S187-S187　2007/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  487. Brain activities related to inferring familiar and unfamiliar persons' decision-makings: An fMRI study Peer-reviewed

    Tachibana Yoshiyuki, Sassa Yuko, Yokoyama Satoru, Sugiura Motoaki, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　58　S62　2007

    DOI： 10.1016/j.neures.2007.06.366 　

    ISSN： 0168-0102

  488. Cortical mechanism of positive self-concept: An fMRI study Peer-reviewed

    Fukushima Ai, Sugiura Motoaki, Miura Naoki, Uchida Shinya, Sekiguchi Atsushi, Horie Kaoru, Satoh Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　58　S115　2007

    DOI： 10.1016/j.neures.2007.06.1241 　

    ISSN： 0168-0102

  489. The right temporal region contributes to the self-prospective direction of stress coping style Peer-reviewed

    Sekiguchi Atsushi, Sugiura Motoaki, Yokoyama Satoru, Kanbara Toshimune, Ikuta Naho, Satou Shigeru, Horie Kaoru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　58　S232　2007

    DOI： 10.1016/j.neures.2007.06.536 　

    ISSN： 0168-0102

  490. An fMRI study: Processing of item-situation relationship Peer-reviewed

    Wakusawa Keisuke, Sugiura Motoaki, Sassa Yuko, eong Hyeanjeong, Horie Kaoru, Sato Shigeru, Yokoyama Hiroyuki, Tsuchiya Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　58　S233　2007

    DOI： 10.1016/j.neures.2007.06.541 　

    ISSN： 0168-0102

  491. 日本語の脳内における統語処理と語彙意味処理のfMRI 研究 Peer-reviewed

    神原利宗, 横山悟, 生田奈穂, ジョン-ヒョンジョン, 高橋慶, 関口敦, 宮本正夫, 高橋大厚, 小泉政利, 吉本啓, 堀江薫, 佐藤滋, 川島隆太

    日本認知科学会第24回大会発表論文集　160-165　2007

  492. Who is to marry or to be a friend? An fMRI study of social decision-making Peer-reviewed

    Sugiura Motoaki, Funayama Risa, Sassa Yuko, Jeong Hyeonjeong, Wakusawa Keisuke, Tachibana Yoshiyuki, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　58　S64　2007

    DOI： 10.1016/j.neures.2007.06.375 　

    ISSN： 0168-0102

  493. Two distinct neural networks for semantic access during visual word recognition Peer-reviewed

    Jeong Hyeonjeong, Sugiura Motoaki, Sassa Yuko, Miyamoto Tadao, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　58　S173　2007

    DOI： 10.1016/j.neures.2007.06.739 　

    ISSN： 0168-0102

  494. Reanalysis in Japanese sentence comprehension: An fMRI study Peer-reviewed

    Ikuta Naho, Yokoyama Satoru, Jeong Hyeonjeong, Sugiura Motoaki, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　58　S174　2007

    DOI： 10.1016/j.neures.2007.06.745 　

    ISSN： 0168-0102

  495. Multiple brain networks for visual self-recognition with different sensitivity for motion and body part. Peer-reviewed

    Sugiura M, Sassa Y, Jeong H, Miura N, Akitsuki Y, Horie K, Sato S, Kawashima R

    NeuroImage　32　1905-1917　2006/10

    Publisher: 4

    DOI： 10.1016/j.neuroimage.2006.05.026 　

    ISSN： 1053-8119

  496. 大脳、小脳の各解剖学的構造における局所灰白質量と年齢との相関 1460人の脳MRIを用いたROI解析

    瀧 靖之, 木之村 重男, 佐藤 和則, 後藤 了以, 井上 健太郎, 岡田 賢, 福田 寛, 小野 修一, 川島 隆太

    日本医学放射線学会秋季臨床大会抄録集　42回　S455-S455　2006/09

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  497. An ERP Study of the Integration Process between a Noun and a Numeral Classifier : Semantic or Morpho-Syntactic?

    SAKAI Yumi, IWATA Kazuki, RIERA Jorge, WAN Xiaohong, YOKOYAMA Satoru, SHIMODA Yoshiteru, KAWASHIMA Ryuta, YOSHIMOTO Kei, KOIZUMI Masatoshi

    Cognitive studies　13　(3)　443-454　2006/09/01

    Publisher: 日本認知科学会

    DOI： 10.11225/jcss.13.443 　

    ISSN： 1341-7924

    More details Close

    A numeral quantifier in Japanese consists of a numeral and a classifier that agrees with the type of entity being counted. In this study we investigated, using event-related potentials, brain activities associated with the integration of a numeral classifier and a noun that denotes an entity&frasl;entities being counted.<BR> Based on previous studies, we considered two hypotheses. If semantic processes are crucially involved in the integration of a noun and a numeral classifier, like selectional restriction between a verb and its object, N400 would be found when subjects read incorrect pairs of a noun and a numeral classifier. On the other hand, if the integration of a noun and a numeral classifier is morpho-syntactic in nature, parallel to gender agreement in European languages, then LAN would be elicited.<BR> Results of our experiment showed that mismatch of a noun and a numeral classifier evoked N400. This suggests that a numeral classifier in Japanese semantically selects a noun denoting a certain type of entity.

  498. Cortical mechanisms involved in the processing of verbs: an fMRI study. Peer-reviewed

    Yokoyama S, Miyamoto T, Riera J, Kim J, Akitsuki Y, Iwata K, Yoshimoto K, Horie K, Sato S, Kawashima R

    Journal of cognitive neuroscience　18　1304-1313　2006/08

    Publisher: 8

    DOI： 10.1162/jocn.2006.18.8.1304 　

    ISSN： 0898-929X

  499. Cortical mechanisms of person representation: recognition of famous and personally familiar names. Peer-reviewed

    Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    NeuroImage　31　(2)　853-860　2006/06

    DOI： 10.1016/j.neuroimage.2006.01.002 　

    ISSN： 1053-8119

  500. The neural basis of the hemodynamic response nonlinearity in human primary visual cortex: Implications for neurovascular coupling mechanism Invited Peer-reviewed

    Xiaohong Wan, Jorge Riera, Kazuki Iwata, Makoto Takahashi, Toshio Wakabayashi, Ryuta Kawashima

    NeuroImage　32　(2)　616-625　2006/05

    DOI： 10.1016/j.neuroimage.2006.03.040 　

  501. Brain activation during the course of sentence comprehension Peer-reviewed

    Naho Ikuta, Motoaki Sugiura, Yuko Sassa, Jobu Watanabe, Yuko Akitsuki, Kazuki Iwata, Naoki Miura, Hideyuki Okamoto, Yoshihiko Watanabe, Shigeru Sato, Kaoru Horie, Yoshihiko Matsue, Ryuta Kawashima

    Brain and Language　97　154-161　2006/05/01

    DOI： 10.1016/j.bandl.2005.10.006 　

    ISSN： 0093-934X

  502. Cortical activation in the processing of passive sentences in L1 and L2: an fMRI study. Peer-reviewed

    Yokoyama S, Okamoto H, Miyamoto T, Yoshimoto K, Kim J, Iwata K, Jeong H, Uchida S, Ikuta N, Sassa Y, Nakamura W, Horie K, Sato S, Kawashima R

    NeuroImage　30　570-579　2006/04

    Publisher: 2

    DOI： 10.1016/j.neuroimage.2005.09.066 　

    ISSN： 1053-8119

  503. Artifact reduction for simultaneous EEG/fMRI recording: Adaptive FIR reduction of imaging artifacts Peer-reviewed

    Xiaohong Wan, Kazuki Iwata, Jorge Riera, Masaharu Kitamura, Ryuta Kawashima

    Clinical Neurophysiology　117　(3)　681-692　2006/03

    DOI： 10.1016/j.clinph.2005.07.025 　

    ISSN： 1388-2457

  504. Artifact reduction for EEG/fMRI recording: Nonlinear reduction of ballistocardiogram artifacts Peer-reviewed

    Xiaohong Wan, Kazuki Iwata, Jorge Riera, Torh Ozaki, Masaharu Kitamura, Ryuta Kawashima

    Clinical Neurophysiology　117　(3)　668-680　2006/03

    DOI： 10.1016/j.clinph.2005.12.015 　

    ISSN： 1388-2457

  505. Anatomical and functional mapping of the human brain: Japanese brain image database project Peer-reviewed

    Hiroshi Fukuda, Shigeo Kinomura, Yasuyuki Taki, Ryo Goto, Kentaro Inoue, Ken Okada, Shinya Uchida, Kazunori Sato, Ryuta Kawashima

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　635-+　2006

  506. Cortical mechanisms for risk perception Peer-reviewed

    Sugiura Motoaki, Sekiguchi Atsushi, Wakusawa Keisuke, Sassa Yuko, Jeong Hyeorong, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　55　S132　2006

    ISSN： 0168-0102

  507. Mechanisms for processing of intellectual excitement Peer-reviewed

    Fukushima Ai, Miura Naoki, Uchida Shinya, Sugiura Motoaki, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　55　S196　2006

    ISSN： 0168-0102

  508. Cortical mechanisms of memory transfer between learning and retrieval modes in foreign language word learning Peer-reviewed

    jeong Hyeon Jeong, Sugiura Motoaki, Sassa Yuko, Wakusawa Keisuke, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　55　S197　2006

    ISSN： 0168-0102

  509. Brain networks for communicative speech production: Feeling inference and speech content production Peer-reviewed

    Sassa Yuko, Sugiura Motoaki, Jeong Hyeonjeong, Wakusawa Keisuke, Horie Kaoru, Sato Shigeru, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　55　S262　2006

    ISSN： 0168-0102

  510. The change of brain activation with increase of stimulus presentation rate during the paced visually serial addition test Peer-reviewed

    Shinya Uchida, Jobu Watanabe, Motoaki Sugiura, Naoki Miura, Kazuki Iwata, Shigeo Kinomura, Kazunori Sato, Kaoru Horie, Shigeru Sato, Hiroshi Fukuda, Ryuta Kawashima

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　837-+　2006

    DOI： 10.1142/9781860948800_0090 　

  511. Automatic brain tissue segmentation method from MRI T1-weighted data Peer-reviewed

    Naoki Miura, Makoto Takahashi, Ryuta Kawashima, Masaharu Kitamura

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　1065-+　2006

    DOI： 10.1142/9781860948800_0114 　

  512. Event-related and spontaneous EEG correlates of concurrent functional MRI Peer-reviewed

    Xiaohong Wan, Jorge Riera, Makoto Takahashi, Toshio Wakabayashi, Ryuta Kawashima

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　1105-+　2006

    DOI： 10.1142/9781860948800_0119 　

  513. Male elderly subthreshold depression patients have smaller volume of medial part of prefrontal cortex and precentral gyrus compared with age-matched normal subjects: a voxel-based morphometry.0 Peer-reviewed

    Taki Yasuyuki, Kinomura Shigeo, Awata Shuichi, Inoue Kentaro, Sato Kazunori, Ito Hiroshi, Goto Ryoi, Uchida Shinya, Tsuji Ichiro, Arai Hiroyuki, Kawashima Ryuta, Fukuda Hiroshi

    J Affect Disord　88　(3)　313-320　2005/11

    DOI： 10.1016/j.jad.2005.08.003 　

  514. "年齢相応の脳"とは?(第1報)

    瀧 靖之, 木之村 重男, 後藤 了以, 佐藤 和則, 伊藤 浩, 井上 健太郎, 岡田 賢, 小野 修一, 川島 隆太, 福田 寛

    臨床放射線　50　(8)　983-990　2005/08

    Publisher: 金原出版(株)

    ISSN： 0009-9252

  515. Brain activities related to the integration of nouns and numeral classifiers in Japanese : An ERP study

    SAKAI Yumi, IWATA Kazuki, RIERA Jorge, WAN Xiaohong, YOKOYAMA Satoru, SHIMODA Yoshiteru, KAWASHIMA Ryuta, YOSHIMOTO Kei, KOIZUMI Masatoshi

    Technical report of IEICE. Thought and language　105　(170)　17-22　2005/07/02

    Publisher: 社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    Numeral classifiers (e.g. -hiki, -hon) are the suffixes used with numbers, which we usually use to count certain objects. The nouns choose what type of specific numeral classifiers should associate with them. The purpose of this study is to reveal, by using ERPs, what kind of brain activities are taking place when Japanese native speakers integrate nouns and numeral classifiers. Results of our experiment showed that mismatch of a noun and a numeral classifier evoked N400. This suggests that semantic processes are crucially involved in the integration of nouns and numeral classifiers in Japa...

  516. Cortical activation during reading of ancient versus modern Japanese texts: fMRI study Peer-reviewed

    Naoki Miura, Jobu Watanabe, Kazuki Iwata, Yuko Sassa, Jorge Riera, Hideo Tsuchiya, Shigeru Sato, Kaoru Horie, Makoto Takahashi, Masaharu Kitamura, Ryuta Kawashima

    NeuroImage　26　426-431　2005/06/01

    DOI： 10.1016/j.neuroimage.2005.01.041 　

    ISSN： 1053-8119

  517. Brain activity analysis during meter inspection using functional MRI Peer-reviewed

    MIURA Naoki, WATANABE Jobu, TAKAHASHI Makoto, KAWASHIMA Ryuta, KITAMURA Masaharu

    Human interface　7　(2)　199-206　2005/05/25

    Publisher: ヒュ-マンインタフェ-ス学会

    ISSN： 1344-7262

  518. Development of integrated remote DB system for brain image management

    Wong Tze Poh Kelvin, Diantono Catur, Makoto Takahashi, Ryuta Kawashima, Masaharu Kitamura

    Proceedings of the SICE Annual Conference　2416-2419　2005

  519. Cortical mechanisms of visual self-recognition. Peer-reviewed

    Sugiura M, Watanabe J, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    NeuroImage　24　143-149　2005/01/01

    Publisher: 1

    DOI： 10.1016/j.neuroimage.2004.07.063 　

    ISSN： 1053-8119

  520. Mental visual synthesis is originated in the fronto-temporal network of the left hemisphere Peer-reviewed

    Yukihito Yomogida, Motoaki Sugiura, Jobu Watanabe, Yuko Akitsuki, Yuko Sassa, Teruyuki Sato, Yoshihiko Matsue, Ryuta Kawashima

    Cerebral Cortex　14　(12)　1376-1383　2004/12

    DOI： 10.1093/cercor/bhh098 　

    ISSN： 1047-3211

  521. Development of a Tablet device-based Neuroimage Analysis Support System Peer-reviewed

    W.T.P. Kelvin, Makoto Takahashi, Ryuta Kawashima, Masaharu Kitamura

    Proceedings of CSEPC2004 (Cognitive System Engineering in Process Control)　1　121-126　2004/11

  522. Different roles of the frontal and parietal regions in memory-guided saccade: a PCA approach on time course of BOLD signal changes. Peer-reviewed

    Sugiura M, Watanabe J, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    Human brain mapping　23　129-139　2004/11

    Publisher: 3

    DOI： 10.1002/hbm.20049 　

    ISSN： 1065-9471

  523. 作業記憶課題における刺激呈示速度変化に伴う脳活動量の検討(Brain activation with the changes of presentation rate of stimulus during a working memory task)

    内田 信也, 岩田 一樹, 渡辺 丈夫, 佐々 祐子, 三浦 直樹, 木之村 重男, 佐藤 和則, 福田 寛, 川島 隆太

    神経化学　43　(2-3)　575-575　2004/08

    Publisher: (一社)日本神経化学会

    ISSN： 0037-3796

  524. Target dependency of brain mechanism involved in dispositional inference: a PET study Peer-reviewed

    M Sugiura, R Gotoh, K Okada, K Yamaguchi, M Itoh, H Fukuda, R Kawashima

    NEUROIMAGE　21　(4)　1377-1386　2004/04

    DOI： 10.1016/j.neuroimage.2003.11.021 　

    ISSN： 1053-8119

  525. Voxel-based morphometry of human brain with age and cerebrovascular risk factors. Peer-reviewed

    Taki Y, Goto R, Evans A, Zijdenbos A, Neelin P, Lerch J, Sato K, Ono S, Kinomura S, Nakagawa M, Sugiura M, Watanabe J, Kawashima R, Fukuda H

    Neurobiology of aging　25　(4)　455-463　2004/04

    DOI： 10.1016/j.neurobiolaging.2003.09.002 　

    ISSN： 0197-4580

  526. The human parietal cortex is involved in spatial processing of tongue movement - An fMRI study Peer-reviewed

    Jobu Watanabe, Motoaki Sugiura, Naoki Miura, Yoshihiko Watanabe, Yasuhiro Maeda, Yoshihiko Matsue, Ryuta Kawashima

    NeuroImage　21　1289-1299　2004/04/01

    DOI： 10.1016/j.neuroimage.2003.10.024 　

    ISSN： 1053-8119

  527. A state-space model of the hemodynamic approach: Nonlinear filtering of BOLD signals Peer-reviewed

    Jorge J. Riera, Jobu Watanabe, Iwata Kazuki, Miura Naoki, Eduardo Aubert, Tohru Ozaki, Ryuta Kawashima

    NeuroImage　21　547-567　2004/01/01

    DOI： 10.1016/j.neuroimage.2003.09.052 　

    ISSN： 1053-8119

  528. 皮質下微小梗塞・虚血性病変と皮質灰白質容積変化の関連

    木之村 重男, 後藤 了以, 井上 健太郎, 中川 学, 瀧 靖之, 佐藤 和則, 福田 寛, 川島 隆太

    日本医学放射線学会雑誌　63　(9)　596-597　2003/11

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  529. Can personality traits predict pathological responses to audiovisual stimulation? Peer-reviewed

    Yambe Tomoyuki, Yoshizawa Makoto, Fukudo Shin, Fukuda Hiroshi, Kawashima Ryuta, Shizuka Kazuhiko, Nanka Shunsuke, Tanaka Akira, Abe Ken-ichi, Shouji Tomonori, Hongo Michio, Tabayashi Kouichi, Nitta Shin-ichi

    Biomed Pharmacother　57 Suppl 1　83s-86s　2003/10

    DOI： 10.1016/j.biopha.2003.08.010 　

  530. 映像コンテンツによる視聴覚刺激が生体の自律神経機能に与える影響 Peer-reviewed

    段旭東, 王慶田, 山家智之, 仁田新一, 川島隆太

    Journal of International Society of Life Information Science　21　(2)　455-463　2003/09

  531. Cortical activation during reading aloud of long sentences: fMRI study Peer-reviewed

    Naoki Miura, Kazuki Iwata, Jobu Watanabe, Motoaki Sugiura, Yuko Akitsuki, Yuko Sassa, Naho Ikuta, Hideyuki Okamoto, Yoshihiko Watanabe, Jorge Riera, Yasuhiro Maeda, Yoshihiko Matsue, Ryuta Kawashima

    NeuroReport　14　1563-1566　2003/08/26

    DOI： 10.1097/00001756-200308260-00004 　

    ISSN： 0959-4965

  532. Thinking of the future and past: the roles of the frontal pole and the medial temporal lobes. International-journal

    Jiro Okuda, Toshikatsu Fujii, Hiroya Ohtake, Takashi Tsukiura, Kazuyo Tanji, Kyoko Suzuki, Ryuta Kawashima, Hiroshi Fukuda, Masatoshi Itoh, Atsushi Yamadori

    NeuroImage　19　(4)　1369-80　2003/08

    ISSN： 1053-8119

    More details Close

    Human lesion data have indicated that the frontal polar area might be critically involved in having an insight into one's future. Retrospective memory mediated by medial temporal lobes and related structures, on the other hand, could be used to extract one's future prospects efficiently. In the present study, we investigated the roles of these two brain structures in thinking of the future and past by using positron emission tomography (PET) and a naturalistic task setting. We measured regional cerebral blood flow (rCBF) in healthy subjects while they were talking about their future prospects or past experiences, with regard to two different temporal windows (in years or days). Many areas in the frontal and the medial temporal lobes were activated during the future and past tasks compared with a control task requiring semantic retrieval. Among these, areas in anteromedial frontal pole showed greater activation during the future tasks than during the past tasks, showing significant effect of temporal distance from the present. Most areas in the medial temporal lobes showed greater or equivalent level of activations during the future tasks compared with the past tasks. The present results suggest that thinking of the future is closely related to retrospective memory, but that specific areas in the frontal pole and the medial temporal lobes are more involved with thinking of the future than that of the past.

  533. Context-dependent cortical activation in response to financial reward and penalty: an event-related fMRI study. Peer-reviewed

    Akitsuki Yuko, Sugiura Motoaki, Watanabe Jobu, Yamashita Keiichi, Sassa Yuko, Awata Shuichi, Matsuoka Hiroo, Maeda Yasuhiro, Matsue Yoshihiko, Fukuda Hiroshi, Kawashima Ryuta

    Neuroimage　19　(4)　1674-1685　2003/08

    Publisher: Elsevier BV

    DOI： 10.1016/S1053-8119(03)00250-7 　

    ISSN： 1053-8119

  534. ヒトの脳における加齢,脳血管危険因子と灰白質,白質の形態変化との相関

    瀧 靖之, 川島 隆太, 後藤 了以, 佐藤 和則, 小野 修一, 木之村 重男, 中川 学, 杉浦 元亮, 渡辺 丈夫, 福田 寛

    加齢医学研究所雑誌　54　(1～2)　50-50　2003/03

    Publisher: 東北大学加齢医学研究所

    ISSN： 1340-3397

  535. 追跡眼球運動と注意－fMRI所見を中心に－

    松江克彦, 前田泰弘, 渡部芳彦, 佐藤優子, 杉浦元亮, 月浦崇, 長谷川武弘, 上埜高志, 川島隆太

    東北福祉大学感性福祉研究所年報　4　47-53　2003/03

  536. Neuroanatomical database of normal Japanese brains Peer-reviewed

    Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Ryuta Kawashima

    Neural Networks　16　(9)　1301-1310　2003

    Publisher: Elsevier Ltd

    DOI： 10.1016/j.neunet.2003.06.004 　

    ISSN： 0893-6080

  537. Time-dependent contribution of the hippocampal complex when remembering the past: a PET study. Peer-reviewed

    Tsukiura T, Fujii T, Okuda J, Ohtake H, Kawashima R, Itoh M, Fukuda H, Yamadori A

    Neuroreport　13　2319-2323　2002/12

    Publisher: 17

    DOI： 10.1097/01.wnr.0000044989.13025.79 　

    ISSN： 0959-4965

  538. Automatic brain tissue extraction method using erosion-dilation treatment (BREED) from three-dimensional magnetic resonance imaging T1-weighted data Peer-reviewed

    Naoki Miura, Akito Taneda, Kazuhito Shida, Ryuta Kawashima, Yoshiyuki Kawazoe, Hiroshi Fukuda, Toshio Shimizu

    Journal of Computer Assisted Tomography　26　927-932　2002/11/01

    DOI： 10.1097/00004728-200211000-00012 　

    ISSN： 0363-8715

  539. 脳血流SPECTカウントは脳灰白質密度を反映するか?

    木之村 重男, 後藤 了以, 井上 健太郎, 中川 学, 瀧 靖之, 佐藤 和則, 川島 隆太, 福田 寛

    核医学　39　(3)　377-377　2002/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  540. Brain activation during the fist-edge-palm test: a functional MRI study. Peer-reviewed

    Umetsu A, Okuda J, Fujii T, Tsukiura T, Nagasaka T, Yanagawa I, Sugiura M, Inoue K, Kawashima R, Suzuki K, Tabuchi M, Murata T, Mugikura S, Higano S, Takahashi S, Fukuda H, Yamadori A

    NeuroImage　17　(1)　385-392　2002/09

    Publisher: 1

    DOI： 10.1006/nimg.2002.1218 　

    ISSN： 1053-8119

  541. Neural basis of the retrieval of people's names: evidence from brain-damaged patients and fMRI. Peer-reviewed

    Tsukiura T, Fujii T, Fukatsu R, Otsuki T, Okuda J, Umetsu A, Suzuki K, Tabuchi M, Yanagawa I, Nagasaka T, Kawashima R, Fukuda H, Takahashi S, Yamadori A

    Journal of cognitive neuroscience　14　922-937　2002/08

    Publisher: 6

    DOI： 10.1162/089892902760191144 　

    ISSN： 0898-929X

  542. Brain Activities for Sentence Processing

    SASSA Yuko, SUGIURA Motoaki, WATANABE Jobu, AKITSUKI Yuko, SATO Shigeru, KAWASHIMA Ryuta

    IPSJ SIG Notes　2002　(66)　91-97　2002/07/15

    Publisher: 社団法人情報処理学会

    ISSN： 0919-6072

    More details Close

    When we hear a sentence, we immediately process syntactic and semantic information, which are two distinct types of linguistic information. However, it remains unclear whether both types are processed in different brain networks or not. To clarify this, we investigated the brain regions involved in syntactic or semantic information using functional magnetic resonance imaging (fMRI). These data indicate that the bilateral inferior parietal lobule is more involved in syntactic processing than semantic processing, whereas the inferior frontal gyrus is more involved in semantic processing than syntactic processing. These findings suggest that both syntactic and semantic processing occur in the same network, the fronto parietal network, rather than being spatially dissociated.

  543. Brain Activities for Sentence Processing

    SASSA Yuko, SUGIURA Motoaki, WATANABE Jobu, AKITSUKI Yuko, SATO Shigeru, KAWASHIMA Ryuta

    IEICE technical report. Natural language understanding and models of communication　102　(199)　91-97　2002/07/08

    Publisher: 社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    When we hear a sentence, we immediately process syntactic and semantic information, which are two distinct types of linguistic information. However, it remains unclear whether both types are processed in different brain networks or not. To clarify this, we investigated the brain regions involved in syntactic or semantic information using functional magnetic resonance imaging (fMRI). These data indicate that the bilateral inferior parietal lobule is more involved in syntactic processing than semantic processing, whereas the inferior frontal gyrus is more involved in semantic processing than syntactic processing. These findings suggest that both syntactic and semantic processing occur in the same network, the fronto parietal network, rather than being spatially dissociated.

  544. Direction of cross-modal information transfer affects human brain activation: a PET study Peer-reviewed

    R Kawashima, J Watanabe, T Kato, A Nakamura, K Hatano, T Schormann, K Sato, H Fukuda, K Ito, K Zilles

    EUROPEAN JOURNAL OF NEUROSCIENCE　16　(1)　137-144　2002/07

    DOI： 10.1046/j.1460-9568.2002.02053.x 　

    ISSN： 0953-816X

  545. The role of the basal forebrain in episodic memory retrieval: a positron emission tomography study. Peer-reviewed

    Fujii T, Okuda J, Tsukiura T, Ohtake H, Miura R, Fukatsu R, Suzuki K, Kawashima R, Itoh M, Fukuda H, Yamadori A

    NeuroImage　15　501-508　2002/03

    Publisher: 3

    DOI： 10.1006/nimg.2001.0995 　

    ISSN： 1053-8119

  546. 脳萎縮に関わる危険因子 MR画像による解析

    瀧 靖之, 川島 隆太, 小野 修一, 木之村 重男, 後藤 了以, 佐藤 和則, 福田 寛

    加齢医学研究所雑誌　53　(1～2)　15-15　2002/02

    Publisher: 東北大学加齢医学研究所

    ISSN： 1340-3397

  547. The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study Peer-reviewed

    Jobu Watanabe, Motoaki Sugiura, Kazunori Sato, Yuko Sato, Yasuhiro Maeda, Yoshihiko Matsue, Hiroshi Fukuda, Ryuta Kawashima

    NeuroImage　17　(3)　1207-1216　2002

    Publisher: Academic Press Inc.

    DOI： 10.1006/nimg.2002.1198 　

    ISSN： 1053-8119

  548. Hypoperfusion in the supplementary motor area, dorsolateral prefrontal cortex and insular cortex in Parkinson's disease

    A Kikuchi, A Takeda, T Kimpara, M Nakagawa, R Kawashima, M Sugiura, S Kinomura, H Fukuda, K Chida, N Okita, S Takase, Y Itoyama

    JOURNAL OF THE NEUROLOGICAL SCIENCES　193　(1)　29-36　2001/12

    DOI： 10.1016/S0022-510X(01)00641-4 　

    ISSN： 0022-510X

  549. Different distribution of the activated areas in the dorsal premotor cortex during visual and auditory reaction-time tasks. Peer-reviewed

    Sugiura M, Kawashima R, Takahashi T, Xiao R, Tsukiura T, Sato K, Kawano K, Iijima T, Fukuda H

    NeuroImage　14　(5)　1168-1174　2001/11

    Publisher: 5

    DOI： 10.1006/nimg.2001.0898 　

    ISSN： 1053-8119

  550. 個人的知合いと有名人の名前の認知に関与する脳領域:event related fMRI

    杉浦 元亮, 渡辺 丈夫, 佐藤 輝幸, 佐藤 優子, 前田 泰弘, 松江 克彦, 原田 淳, 佐藤 和則, 福田 寛, 川島 隆太

    神経化学　40　(2-3)　403-403　2001/09

    Publisher: (一社)日本神経化学会

    ISSN： 0037-3796

  551. Responses to the Virtual Reality immersion with healing contents

    YAMBE Tomoyuki, KAWASHIMA Ryuuta, SUGIURA Motoaki, NANKA Shunsuke, FUKUDA Hiroshi, YOSHIZAWA Makoto, NITTA Shin-ichi

    生体・生理工学シンポジウム論文集　16　443-446　2001/08/29

  552. Comparison of the cortical activity in association cortices of human before and after drinking : an fMRI study

    TAIRA Masato, KAWASHIMA Ryuta, SUGIURA Motoki, WATANABE Jobu, INOUE Kentaro, KANEGAE Takashi, TSUKAMOTO Shojiro

    日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence　36　(4)　314-315　2001/08/28

    ISSN： 1341-8963

  553. Activation reduction in anterior temporal cortices during repeated recognition of faces of personal acquaintances Peer-reviewed

    M Sugiura, R Kawashima, K Nakamura, N Sato, A Nakamura, T Kato, K Hatano, T Schormann, K Zilles, K Sato, K Ito, H Fukuda

    NEUROIMAGE　13　(5)　877-890　2001/05

    DOI： 10.1006/nimg.2001.0747 　

    ISSN： 1053-8119

  554. 既知の人物の名前の視覚認知に関与する脳領域:fMRI研究 (1 生命科学部門)

    杉浦 元亮, 川島 隆太, 渡辺 丈夫

    感性福祉研究所年報　(2)　113-118　2001/05

    Publisher: 東北福祉大学感性福祉研究所

    ISSN： 1344-9966

  555. Different neural systems for recognizing plants, animals, and artifacts Peer-reviewed

    R Kawashima, G Hatano, K Oizumi, M Sugiura, H Fukuda, K Itoh, T Kato, A Nakamura, K Hatano, S Kojima

    BRAIN RESEARCH BULLETIN　54　(3)　313-317　2001/02

    ISSN： 0361-9230

  556. 人の性格と脳活動の関係

    杉浦 元亮, 川島 隆太, 中川 学, 岡田 賢, 佐藤 多智雄, 後藤 了以, 佐藤 和則, 小野 修一, 福田 寛

    加齢医学研究所雑誌　52　(1～2)　31-31　2001/01

    Publisher: 東北大学加齢医学研究所

    ISSN： 1340-3397

  557. Neural substrates for recognition of familiar voices: a PET study Peer-reviewed

    K Nakamura, R Kawashima, M Sugiura, T Kato, A Nakamura, K Hatano, S Nagumo, K Kubota, H Fukuda, K Ito, S Kojima

    NEUROPSYCHOLOGIA　39　(10)　1047-1054　2001

    DOI： 10.1016/S0028-3932(01)00037-9 　

    ISSN： 0028-3932

  558. Activation in the ipsilateral posterior parietal cortex during tool use: A PET study Peer-reviewed

    Kentaro Inoue, Ryuta Kawashima, Motoaki Sugiura, Akira Ogawa, Torsten Schormann, Karl Zilles, Hiroshi Fukuda

    NeuroImage　14　(6)　1469-1475　2001

    Publisher: Academic Press Inc.

    DOI： 10.1006/nimg.2001.0942 　

    ISSN： 1053-8119

  559. Functional MRI Measurement During Motion-Imagery Task

    KAMIJO Kenichi, YAMAZAKI Toshimasa, KAWASHIMA Ryuta, SUGIURA Motoaki, WATANABE Takeo, FUKUDA Hiroshi, SATO Yuko, MAEDA Yasuhiro, MATSUE Katsuhiko

    生体・生理工学シンポジウム論文集　15　349-352　2000/10/13

  560. Functional delineation of the human occipito-temporal areas related to face and scene processing - A PET study Peer-reviewed

    K Nakamura, R Kawashima, N Sato, A Nakamura, M Sugiura, T Kato, K Hatano, K Ito, H Fukuda, T Schormann, K Zilles

    BRAIN　123　1903-1912　2000/09

    DOI： 10.1093/brain/123.9.1903 　

    ISSN： 0006-8950

  561. Retention of words in long-term memory: a functional neuroanatomical study with PET Peer-reviewed

    J Okuda, T Fujii, A Yamadori, R Kawashima, T Tsukiura, H Ohtake, R Fukatsu, K Suzuki, M Itoh, H Fukuda

    NEUROREPORT　11　(2)　323-328　2000/02

    DOI： 10.1097/00001756-200002070-00020 　

    ISSN： 0959-4965

  562. Four dimensions in the state of memory and emotion concerned with a person: Factor analysis using subject's self evaluation and PET

    M. Sugiura, Ryuta Kawashima, R. Gotoh, K. Okada, J. Watanabe, K. Satoh, K. Yamaguchi, M. Itoh, T. Schormann, H. Fukuda

    NeuroImage　11　(5 PART II)　2000

    DOI： 10.1016/s1053-8119(00)91171-6 　

    ISSN： 1053-8119

  563. Recognition of the familiar personal names: Event-related fMRI

    M. Sugiura, Ryuta Kawashima, J. Watanabe, R. Gotoh, K. Satoh, Y. Satoh, Y. Maeda, K. Matsue, H. Fukuda

    NeuroImage　11　(5 PART II)　2000

    DOI： 10.1016/s1053-8119(00)91319-3 　

    ISSN： 1053-8119

  564. Recognition of faces - a combined study using PET and MEG Peer-reviewed

    A Nakamura, N Sato, M Sugiura, K Nakamura, R Kawashima, T Kato, K Horibe, T Yamada, Y Abe, T Kachi, K Ito

    POSITRON EMISSION TOMOGRAPHY IN THE MILLENNIUM　1197　79-83　2000

    ISSN： 0531-5131

  565. A PET study of visuomotor learning under optical rotation Peer-reviewed

    Kentaro Inoue, Ryuta Kawashima, Kazunori Satoh, Shigeo Kinomura, Motoaki Sugiura, Ryoi Goto, Masatoshi Ito, Hiroshi Fukuda

    NeuroImage　11　(5 I)　505-516　2000

    Publisher: Academic Press Inc.

    DOI： 10.1006/nimg.2000.0554 　

    ISSN： 1053-8119

  566. Correlation between human personality and neural activity in cerebral cortex Peer-reviewed

    Motoaki Sugiura, Ryuta Kawashima, Manabu Nakagawa, Ken Okada, Tachio Sato, Ryoi Goto, Kazunori Sato, Shuichi Ono, Thorsten Schormann, Karl Zilles, Hiroshi Fukuda

    NeuroImage　11　(5 I)　541-546　2000

    Publisher: Academic Press Inc.

    DOI： 10.1006/nimg.2000.0564 　

    ISSN： 1053-8119

  567. Different time course between scene processing and face processing: a MEG study Peer-reviewed

    N Sato, K Nakamura, A Nakamura, N Sugiura, K Ito, H Fukuda, R Kawashima

    NEUROREPORT　10　(17)　3633-3637　1999/11

    DOI： 10.1097/00001756-199911260-00031 　

    ISSN： 0959-4965

  568. Activation of the right inferior frontal cortex during assessment of facial emotion Peer-reviewed

    K Nakamura, R Kawashima, K Ito, M Sugiura, T Kato, A Nakamura, K Hatano, S Nagumo, K Kubota, H Fukuda, S Kojima

    JOURNAL OF NEUROPHYSIOLOGY　82　(3)　1610-1614　1999/09

    ISSN： 0022-3077

  569. ニューラルネットワークを用いた脳血流SPECTの自動診断法の開発(第1報)

    川島 隆太, 粂川 一也, 佐藤 和則, 後藤 了以, 中川 学, 杉浦 元亮, 小野 修一, 佐藤 多智雄, 福田 寛

    核医学　36　(6)　623-623　1999/08

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  570. The human amygdala plays an important role in gaze monitoring - A PET study Peer-reviewed

    R Kawashima, M Sugiura, T Kato, A Nakamura, K Hatano, K Ito, H Fukuda, S Kojima, K Nakamura

    BRAIN　122　(4)　779-783　1999/04

    DOI： 10.1093/brain/122.4.779 　

    ISSN： 0006-8950

  571. Anatomic validation of spatial normalization methods for PET Peer-reviewed

    Motoaki Sugiura, Ryuta Kawashima, Norihiro Sadato, Michio Senda, Iwao Kanno, Keiichi Oda, Kazunori Sato, Yoshiharu Yonekura, Hiroshi Fukuda

    Journal of Nuclear Medicine　40　(2)　317-322　1999/02

    ISSN： 0161-5505

  572. Parametric mapping of cerebral blood flow deficits in Alzheimer's disease: A SPECT study using HMPAO and Image Standardization Technique Peer-reviewed

    Muhammad Babar Imran, Ryuta Kawashima, Shuichi Awata, Kazunori Sato, Shigeo Kinomura, Shuichi Ono, Seiro Yoshioka, Mitsumoto Sato, Hiroshi Fukuda

    Journal of Nuclear Medicine　40　(2)　244-249　1999/02

    ISSN： 0161-5505

  573. Attention towards direction and speed of optical flow activate bilateral parieto-occipital and intraparietal cortex - A PET study

    Ken Okada, Ryuta Kawashima, Hiroshi Fukuda

    NeuroImage　9　(6)　S778　1999

    ISSN： 1053-8119

  574. Somatotopy in the human cerebellum

    Motoaki Sugiura, Takehiko Bando, Kenogo Ito, Kentaro Hatano, Karl Zilles, Thorsten Schormann, Hiroshi Fukuda, Motoaki Augiura, Ryuta Kawashima, Takashi Kato

    NeuroImage　9　(6)　S515　1999

    ISSN： 1053-8119

  575. Functional PET mapping of human brain in olfactory processing

    Ahmad Qureshy, Ryuta Kawashima, M. B. Imran, Motoaki Sugiura, Ryoi Goto, Ken Okada, Kentarou Inoue, Masatoshi Itoh, Thorsten Schormann, Karl Zilles, Hiroshi Fukuda

    NeuroImage　9　(6)　S807　1999

    ISSN： 1053-8119

  576. Activation of the bilateral parietal cortex during grasping with the tool: A PET study

    Kentaro Inoue, Ryuta Kawashima, Motoaki Sugiura, Akira Ogawa, Thorsten Schormann, Karl Zilles, Hiroshi Fukuda

    NeuroImage　9　(6)　S501　1999

    ISSN： 1053-8119

  577. Regional cerebral blood flow decrease in the Parkinson's disease patients compared with age and brain atrophy matched normal subjects

    Manabu Nakagawa, Akio Kikuchi, Ryuta Kawashima, Atushi Takeda, Shigeo Kinomura, Ryoi Goto, Syuuichi Ono, Tachio Sato, Yasuto Itoyama, Hiroshi Fukuda

    NeuroImage　9　(6)　S579　1999

    ISSN： 1053-8119

  578. Inter-subject and inter-trial variability of brain activation in PET study of face discrimination tasks

    Sugiura, M., Kawashima, R., Nakamura, K., Sato, N., Kato, T., Pakamura, A., Hatano, K., Schormann, T., Itoh, K., Nakamura, A., Zilles, K., Fukuda, H.

    NeuroImage　9　(6 PART II)　1999

    ISSN： 1053-8119

  579. Cerebellar activation in relation to vergence eye movement - Comparison to pursuit and saccadic eye movement

    Takagi, M., Hayakawa, Y., Sugiura, M., Kato, R., Hatano, H., Nakamura, A., Takada, R., Hasebe, H., Oyamada, H., Kawashima, R., Ito, K., Ukai, K., Fukuda, H., Bando, T., Zilles, K., Schormann, T.

    NeuroImage　9　(6 PART II)　1999

    ISSN： 1053-8119

  580. Categorization of sound, onomatopoeia and name of objects: A PET study

    Nakamura, A., Kawashima, R., Ito, K., Sugiura, M., Kato, T., Hatano, K., Nagumo, S., Asakawa, K., Fukuda, H., Kiritani, S., Zilles, K., Schormann, T.

    NeuroImage　9　(6 PART II)　1999

    ISSN： 1053-8119

  581. Human cortical areas activated in relation to vergence eye movements - A PET study Peer-reviewed

    H. Hasebe, H. Oyamada, S. Kinomura, R. Kawashima, Y. Ouchi, S. Nobezawa, H. Tsukada, E. Yoshikawa, K. Ukai, R. Takada, M. Takagi, H. Abe, H. Fukuda, T. Bando

    NeuroImage　10　(2)　200-208　1999

    Publisher: Academic Press Inc.

    DOI： 10.1006/nimg.1999.0453 　

    ISSN： 1053-8119

  582. Selective visual and auditory attention toward utterances - A PET study Peer-reviewed

    Ryuta Kawashima, Satoshi Imaizumi, Koichi Mori, Ken Okada, Ryoi Goto, Shigeru Kiritani, Akira Ogawa, Hiroshi Fukuda

    NeuroImage　10　(2)　209-215　1999

    Publisher: Academic Press Inc.

    DOI： 10.1006/nimg.1999.0452 　

    ISSN： 1053-8119

  583. 「Elast」による脳画像の形態的標準化

    杉浦 元亮, 川島 隆太, 佐藤 和則, 福田 寛

    核医学　35　(9)　957-957　1998/11

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  584. Participation of the prefrontal cortices in prospective memory: evidence from a PET study in humans Peer-reviewed

    Okuda J, Fujii T, Yamadori A, Kawashima R, Tsukiura T, Fukatsu R, Suzuki K, Ito M, Fukuda H

    Neuroscience Letters　253　127-130　1998/09

    DOI： 10.1016/S0304-3940(98)00628-4 　

    ISSN： 0304-3940

  585. The role of the left inferior temporal cortex for visual pattern discrimination - A PET study Peer-reviewed

    Ryuta Kawashima, Kazunori Satoh, Ryoi Goto, Kentaro Inoue, Masatoshi Itoh, Hiroshi Fukuda

    NeuroReport　9　(7)　1581-1586　1998/05/11

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1097/00001756-199805110-00060 　

    ISSN： 0959-4965

  586. Neuroanatomical correlates of the assessment of facial attractiveness Peer-reviewed

    K Nakamura, R Kawashima, S Nagumo, K Ito, M Sugiura, T Kato, A Nakamura, K Hatano, K Kubota, H Fukuda, S Kojima

    NEUROREPORT　9　(4)　753-757　1998/03

    DOI： 10.1097/00001756-199803090-00035 　

    ISSN： 0959-4965

  587. A PET study of axis orientation discrimination Peer-reviewed

    Masato Taira, Ryuta Kawashima, Kentaro Inoue, Hiroshi Fukuda

    NeuroReport　9　(2)　283-288　1998/01/26

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1097/00001756-199801260-00020 　

    ISSN： 0959-4965

  588. Shifting attention to left or right hemi-visualfield activates left parietal cortex.: A PET study

    Shigeo Kinomura, Ryuta Kawashima, Kenntaro Inoue, Motoaki Sugiura, Kenn Okada, Hiroshi Fukuda, Masatoshi Itoh, Takehiko Fujiwara

    NeuroImage　7　(4)　S72　1998

    Publisher: Academic Press Inc.

    DOI： 10.1016/s1053-8119(18)30905-4 　

    ISSN： 1053-8119

  589. Cortical activation during visuomotor learning with optical rotation

    Kentaro Inoue, Ryuta Kawashima, Kazunori Satoh, Shigeo Kinomura, Ryoi Goto, Motoaki Sugiura, Masatoshi Ito, Hiroshi Fukuda

    NeuroImage　7　(4 PART II)　1998

    DOI： 10.1016/s1053-8119(18)31717-8 　

    ISSN： 1053-8119

  590. Mean regional cerebral blood flow images of normal subjects using Technetium-99m-HMPAO by automated image registration

    Muhammad Babar Imran, Ryuta Kawashima, Kazunori Sato, Shigeo Kinomura, Hiroshi Ito, Masamichi Koyama, Ryoi Goto, Shuichi Ono, Seiro Yoshioka, Hiroshi Fukuda

    Journal of Nuclear Medicine　39　(1)　203-207　1998/01

    ISSN： 0161-5505

  591. Oculomotor sequence learning: A PET study

    R. Kawashima, K. Okada, M. Sugiura, K. Sato, S. Kinomura, K. Inoue, H. Fukuda

    NeuroImage　7　(4 PART II)　1998

    DOI： 10.1016/s1053-8119(18)31719-1 　

    ISSN： 1053-8119

  592. Recognition of familiar people from their voices: A PET study

    Nakamura, K., Kawashima, R., Ito, K., Sugiura, M., Kato, T., Nakamura, A., Hatano, K., Nagumo, S., Kubota, K., Fukuda, H., Kojima, S.

    NeuroImage　7　(4 PART II)　1998

    DOI： 10.1016/s1053-8119(18)31665-3 　

    ISSN： 1053-8119

  593. The inner representation of the self: PET activation study

    Sugiura, M., Kawashima, R., Nakamura, K., Okada, K., Kato, T., Nakamura, A., Hatano, K., Itoh, K., Kojima, S., Fukuda, H.

    NeuroImage　7　(4 PART II)　1998

    DOI： 10.1016/s1053-8119(18)31181-9 　

    ISSN： 1053-8119

  594. Influence of ANOVA design and anatomical standardization on statistical mapping for PET activation Peer-reviewed

    Michio Senda, Kenji Ishii, Keiichi Oda, Norihiro Sadato, Ryuta Kawashima, Motoaki Sugiura, Iwao Kanno, Babak Ardekani, Satoshi Minoshima, Itaru Tatsumi

    NeuroImage　8　(3)　283-301　1998

    Publisher: Academic Press Inc.

    DOI： 10.1006/nimg.1998.0370 　

    ISSN： 1053-8119

  595. Use of automated image registration to generate mean brain SPECT image of Alzheimer's patients Peer-reviewed

    Muhammad Babar Imran, Ryuta Kawashima, Shuichi Awata, Kazunori Sato, Shigeo Kinomura, Hiroshi Ito, Shuichi Ono, Seiro Yoshioka, Mitsumoto Sato, Hiroshi Fukuda

    Annals of Nuclear Medicine　12　(3)　127-132　1998

    Publisher: Springer Tokyo

    DOI： 10.1007/BF03164776 　

    ISSN： 0914-7187

  596. PET study of pointing with visual feedback of moving hands Peer-reviewed

    Kentaro Inoue, Ryuta Kawashima, Kazunori Satoh, Shigeo Kinomura, Ryoi Goto, Masamichi Koyama, Motoaki Sugiura, Masatoshi Ito, Hiroshi Fukuda

    Journal of Neurophysiology　79　(1)　117-125　1998

    Publisher: American Physiological Society

    DOI： 10.1152/jn.1998.79.1.117 　

    ISSN： 0022-3077

  597. Oculomotor sequence learning: A positron emission tomography study Peer-reviewed

    Ryuta Kawashima, Jun Tanji, Ken Okada, Motoaki Sugiura, Kazunori Sato, Shigeo Kinomura, Kentaro Inoue, Akira Ogawa, Hiroshi Fukuda

    Experimental Brain Research　122　(1)　1-8　1998

    DOI： 10.1007/s002210050485 　

    ISSN： 0014-4819

  598. Activity in the parietal area during visuomotor learning with optical rotation Peer-reviewed

    Kentaro Inoue, Ryuta Kawashima, Kazunori Satoh, Shigeo Kinomura, Ryoi Goto, Motoaki Sugiura, Masatoshi Ito, Hiroshi Fukuda

    NeuroReport　8　(18)　3979-3983　1997/12/22

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1097/00001756-199712220-00026 　

    ISSN： 0959-4965

  599. Vocal identification of speaker and emotion activates different brain regions Peer-reviewed

    S Imaizumi, K Mori, S Kiritani, R Kawashima, M Sugiura, H Fukuda, K Itoh, T Kato, A Nakamura, K Hatano, S Kojima, K Nakamura

    NEUROREPORT　8　(12)　2809-2812　1997/08

    DOI： 10.1097/00001756-199708180-00031 　

    ISSN： 0959-4965

  600. Different roles of the left and right parahippocampal regions in verbal recognition: A PET study Peer-reviewed

    T Fujii, J Okuda, R Kawashima, A Yamadori, R Fukatsu, K Suzuki, M Ito, R Goto, H Fukuda

    NEUROREPORT　8　(5)　1113-1117　1997/03

    ISSN： 0959-4965

  601. Functional asymmetry of cortical motor control in left-handed subjects Peer-reviewed

    Ryuta Kawashima, Kentaro Inoue, Kazunori Sato, Hiroshi Fukuda

    NeuroReport　8　(7)　1729-1732　1997

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1097/00001756-199705060-00032 　

    ISSN： 0959-4965

  602. 11C-Benztropineによるムスカリン作動性アセチルコリン受容体の脳内分布の解析 解剖学的標準化を用いて Peer-reviewed

    小野修一, 川島隆太, 伊藤浩, 他

    核医学　33　(7)　721-727　1996/07

  603. Regional cerebral blood flow changes of cortical motor areas and prefrontal areas in humans related to ipsilateral and contralateral hand movement

    Ryuta Kawashima, Kenji Yamada, Shigeo Kinomura, Tatsuo Yamaguchi, Hiroshige Matsui, Seiro Yoshioka, Hiroshi Fukuda

    Brain Research　623　(1)　33-40　1993/09/24

    DOI： 10.1016/0006-8993(93)90006-9 　

    ISSN： 0006-8993

Show all ︎Show first 5

Misc. 381

  1. Neural basis of understanding and executing the meaning-mediated hand transverse patterning task

    塙杉子, 塙杉子, 塙杉子, ティロー バンジャマン, 野澤孝之, 野澤孝之, 鄭嫣てい, 鄭嫣てい, 川島隆太

    日本作業療法学会抄録集(CD-ROM)　57th　2023

    ISSN： 1880-6635

  2. Power of words: Categorization of positive phrases and their effectiveness associated with personality, well-being and distress.

    Ryo Ishibashi, Aki Eisenman-Shoda, Motoaki Sugiura, Takayuki Nozawa, Ryuta Kawashima

    The 20th Conference of the Japanese Society for Cognitive Psychology　2022/10

    DOI： 10.14875/cogpsy.2022.0_67 　

  3. 聴性誘発脳磁界 (N1m) -音楽による影響と選択的注意-

    白倉真之, 川瀬哲明, 川瀬哲明, 菅野彰剛, 菅野彰剛, 太田淳, 中里信和, 中里信和, 川島隆太, 香取幸夫

    臨床神経生理学(Web)　50　(4)　2022

    ISSN： 2188-031X

  4. Lutein Has a Positive Impact on Brain Health in Healthy Older Adults: A Systematic Review of Randomized Controlled Trials and Cohort Studies

    Ayano Yagi, Rui Nouchi, Laurie Butler, Ryuta Kawashima

    NUTRIENTS　13　(6)　2021/06

    DOI： 10.3390/nu13061746 　

    eISSN： 2072-6643

  5. Reveal both behavioral and brain morphological differences between aged and adult wild-type mice (Proceedings of the 80th Annual Meeting of the Japanese Society for Animal Psychology)

    Rie Ryoke, Hiroi Nonaka, Masatoshi Hirobe, Ryuta Kawashima

    Japanese Journal of Animal Psychology　71　(1)　99-99　2021

    Publisher: Japanese Society of Animal Psychology

    DOI： 10.2502/janip.71.1.8 　

    ISSN： 0916-8419

    eISSN： 1880-9022

  6. 聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

    白倉真之, 川瀬哲明, 川瀬哲明, 菅野彰剛, 菅野彰剛, 太田淳, 中里信和, 中里信和, 川島隆太, 香取幸夫

    臨床神経生理学(Web)　49　(5)　2021

    ISSN： 2188-031X

  7. 睡眠習慣の相違によるうつ状態と慢性疲労との弁別

    中川誠秀, 中川誠秀, 竹内光, 瀧靖之, 野内類, 関口敦, 宮内誠カルロス, 飯塚邦夫, 横山諒一, 塙杉子, 榊浩平, ジョン ビヨンジョン, ジョン ビヨンジョン, 川島隆太

    日本うつ病学会総会プログラム・抄録集　17th　2021

  8. Connectome Prediction Model for representation of individual cognitive functions

    小川剛史, 竹内光, 池田純起, 瀧靖之, 野内類, 横山諒一, 事崎由佳, 中川誠秀, 関口敦, 飯塚邦夫, 塙杉子, 荒木剛, 宮内カルロス誠, 榊浩平, 佐々祐子, 野澤孝之, 横田晋, MAGISTROP Daniele, 川島隆太

    電子情報通信学会大会講演論文集(CD-ROM)　2021　2021

    ISSN： 1349-144X

  9. DHA摂取による認知症および認知機能低下リスクの低減効果:日本人も含めた前向きコホート研究の系統的レビュー及びメタ分析

    福島洋一, 宮下博樹, 田所智, 渡部大志, 大塚礼, 野澤孝之, 川島隆太

    日本栄養・食糧学会大会講演要旨集　74th　2020

  10. Implications of large-sample neuroimaging studies of creativity measured by divergent thinking

    Hikaru Takeuchi, Ryuta Kawashima

    Current Opinion in Behavioral Sciences　27　139-145　2019/06/01

    Publisher: Elsevier Ltd

    DOI： 10.1016/j.cobeha.2018.12.009 　

    ISSN： 2352-1546

  11. Experience to take another’s perspective enhance the right parieto-frontal activation Peer-reviewed

    Miura N, Sugiura M, Nozawa T, Yamamoto Y, Sasaki Y, Hamamoto Y, Yamazaki S, Hirano K, Takahashi M, Kawashima R

    2019 OHBM Annual Meeting　2019/06

  12. 東北大学病院の「てんかん脳磁図・ベスト・オブ・ザ・ベスト」

    神 一敬, 柿坂庸介, 石田 誠, 菅野彰剛, 岩崎真樹, 川島隆太, 中里信和

    日本生体磁気学会誌　32　(1)　62-63　2019/06

  13. 側頭葉てんかん患者の体性感覚誘発磁界の信号強度は覚醒時のみ抑制される

    石田 誠, 神 一敬, 柿坂庸介, 菅野彰剛, 川島隆太, 中里信和

    日本生体磁気学会誌　32　(1)　150-151　2019/06

  14. Neural Integration of Linguistic Expressions and Sociocultural Conventions in Comprehending Socio-pragmatic Knowledge: The Case of Japanese Honorific Expressions

    CUI Haining, JEONG Hyeonjeong, OKAMOTO Kiyo, TAKAHASHI Daiko, KAWASHIMA Ryuta, SUGIURA Motoaki

    日本神経化学会大会抄録集(Web)　62nd　2019

  15. MRIを用いた緑内障患者の眼球形態の検討

    國時景子, 國時景子, 舘脇康子, 面高宗子, 松平泉, THYREAU Benjamin, 武藤達士, 川島隆太, 中澤徹, 瀧靖之, 瀧靖之

    日本疫学会学術総会講演集(Web)　29th　2019

  16. オリゴデンドロサイト関連遺伝子多型(rs1059004)と自己スキーマ及び抑うつ症状との相関研究

    小松浩, 小松浩, 竹内光, 菊地淑恵, 小野千晶, 兪志前, 兪志前, 飯塚邦夫, 角藤芳久, 舩越俊一, 舩越俊一, 大野高志, 川島隆太, 川島隆太, 川島隆太, 瀧靖之, 瀧靖之, 瀧靖之, 富田博秋, 富田博秋, 富田博秋, 富田博秋

    日本うつ病学会総会プログラム・抄録集　16th　2019

  17. 音程調整を伴う発声における早期の脳活動について―脳磁図を用いた検討―

    野村有理, 川瀬哲明, 川瀬哲明, 菅野彰剛, 中里信和, 中里信和, 川島隆太, 香取幸夫

    日本ヒト脳機能マッピング学会プログラム・抄録集　21st　93　2019

  18. A refined model of chronic cerebral hypoperfusion resulting in cognitive impairment and a low mortality rate in rats. International-journal

    Ahmed Mansour, Kuniyasu Niizuma, Sherif Rashad, Akira Sumiyoshi, Rie Ryoke, Hidenori Endo, Toshiki Endo, Kenichi Sato, Ryuta Kawashima, Teiji Tominaga

    Journal of neurosurgery　131　(3)　892-902　2018/09/07

    DOI： 10.3171/2018.3.JNS172274 　

    More details Close

    OBJECTIVE: The cognitive deficits of vascular dementia and the vasoocclusive state of moyamoya disease have often been mimicked with bilateral stenosis/occlusion of the common carotid artery (CCA) or internal carotid artery. However, the cerebral blood flow (CBF) declines abruptly in these models after ligation of the CCA, which differs from "chronic" cerebral hypoperfusion. While some modified but time-consuming techniques have used staged occlusion of both CCAs, others used microcoils for CCA stenosis, producing an adverse effect on the arterial endothelium. Thus, the authors developed a new chronic cerebral hypoperfusion (CCH) model with cognitive impairment and a low mortality rate in rats. METHODS: Male Sprague-Dawley rats were subjected to unilateral CCA occlusion and contralateral induction of CCA stenosis (modified CCA occlusion [mCCAO]) or a sham operation. Cortical regional CBF (rCBF) was measured using laser speckle flowmetry. Cognitive function was assessed using a Barnes circular maze (BCM). MRI studies were performed 4 weeks after the operation to evaluate cervical and intracranial arteries and parenchymal injury. Behavioral and histological studies were performed at 4 and 8 weeks after surgery. RESULTS: The mCCAO group revealed a gradual CBF reduction with a low mortality rate (2.3%). White matter degeneration was evident in the corpus callosum and corpus striatum. Although the cellular density declined in the hippocampus, MRI revealed no cerebral infarctions after mCCAO. Immunohistochemistry revealed upregulated inflammatory cells and angiogenesis in the hippocampus and cerebral cortex. Results of the BCM assessment indicated significant impairment in spatial learning and memory in the mCCAO group. Although some resolution of white matter injury was observed at 8 weeks, the animals still had cognitive impairment. CONCLUSIONS: The mCCAO is a straightforward method of producing a CCH model in rats. It is associated with a low mortality rate and could potentially be used to investigate vascular disease, moyamoya disease, and CCH. This model was verified for an extended time point of 8 weeks after surgery.

  19. ポジティブ思考の想像学習による社交不安低減法の神経基盤の解明

    榊浩平, 榊浩平, 榊浩平, 野澤孝之, 池田純起, 川島隆太

    日本心理学会大会発表論文集　82nd　(0)　524-524　2018/08

    Publisher: (公社)日本心理学会

  20. 東日本大震災後の慢性疲労と他者との関わり合い

    中川 誠秀, 杉浦 元亮, 関口 敦, 事崎 由佳, 荒木 剛, 塙 杉子, 宮内 誠カルロス, 佐久間 篤, 川島 隆太

    日本社会精神医学会雑誌　27　(3)　216-216　2018/08

    Publisher: (一社)日本社会精神医学会

    ISSN： 0919-1372

  21. Bilinguals’ lexical access of cognates in the brain: Effects of language memberships Peer-reviewed

    Hsieh MC, Jeong H, Sugiura M, Kawashima R

    Proceedings of The 20th Annual International Conference of the Japanese Society for Language Sciences,　34-37　2018/08

  22. OLIG2遺伝子多型(rs1059004)と統合失調症との関連、白質統合性、安静時脳灌流量及び認知機能への影響の検討

    小松 浩, 竹内 光, 菊地 淑恵, 小野 千晶, 角藤 芳久, 舩越 俊一, 大野 高志, 山森 秀長, 安田 由華, 藤本 美智子, 畦地 裕統, 工藤 紀子, 川島 隆太, 橋本 亮太, 瀧 靖之, 富田 博秋

    精神神経学雑誌　(2018特別号)　S656-S656　2018/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  23. MRI平均拡散率を用いた集団主義の神経基盤の同定

    中川誠秀, 竹内光, 瀧靖之, 瀧靖之, 野内類, 野内類, 事崎由佳, 品田貴光, 丸山司, 関口敦, 関口敦, 飯塚邦夫, 横山諒一, 山本悠貴, 塙杉子, 荒木剛, 宮内誠カルロス, MAGISTRO Daniele, 榊浩平, 鄭嫣てい, 鄭嫣てい, 佐々木結咲子, 川島隆太

    日本精神神経学会総会プログラム・抄録集　114th　(2018特別号)　S655-S655　2018/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  24. 脳磁図は体性感覚誘発性棘波様活動を成人でも観察できる

    石田誠, 菅野彰剛, 柿坂庸介, 神 一敬, 上利大, 川島隆太, 中里信和

    日本生体磁気学会誌　31　(1)　102-103　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  25. 読み聞かせ習慣と幼児の言語発達・問題行動および養育者のストレスとの関連

    松崎泰, 池田純起, 川島隆太, 川島隆太, 川島隆太

    日本コミュニケーション障害学会学術講演会予稿集　44th　2018

  26. 自尊心の妬みとシャーデンフロイデ抑制作用の神経メカニズムの解明

    山崎翔平, 杉浦元亮, 河田(サントスケルシ)人美, 佐々木結咲子, 野内類, 榊浩平, 池田純起, 川島隆太

    日本ヒト脳機能マッピング学会プログラム・抄録集　20th　2018

  27. 高齢者における自己の「死」とその恐怖への脳反応:fMRI研究

    平野香南, 大場健太郎, 齊藤俊樹, 山崎翔平, 川島隆太, 杉浦元亮, 杉浦元亮

    日本ヒト脳機能マッピング学会プログラム・抄録集　20th　75　2018

  28. fNIRSハイパースキャニングによる集団学習時の経験共有評価の可能性

    野澤孝之, 近藤睦美, 山本玲子, JEONG Hyeonjeong, 池田純起, 榊浩平, 三宅美博, 石川保茂, 川島隆太

    計測自動制御学会システムインテグレーション部門講演会(CD-ROM)　18th　ROMBUNNO.2B1‐03　2017/12/20

  29. IMPACT OF OLIG2 GENE VARIANT (RS1059004) ON WHITE MATTER TRACT INTEGRITY AND MEAN CEREBRAL BLOOD FLOW OF THE HUMAN BRAIN

    Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Akira Kodaka, Shunichi Funakoshi, Takashi Ono, Yoshihisa Kakuto, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

    EUROPEAN NEUROPSYCHOPHARMACOLOGY　27　S315-S316　2017/10

    ISSN： 0924-977X

    eISSN： 1873-7862

  30. 肥満患者における食渇望の制御機能 fMRI研究

    村椿 智彦, 石垣 泰, 鹿野 理子, 関口 敦, 澤田 正二郎, 近藤 敬一, 事崎 由佳, 佐々木 彩加, 森下 城, 金澤 素, 片桐 秀樹, 川島 隆太, 福土 審

    心身医学　57　(10)　1068-1068　2017/10

    Publisher: (一社)日本心身医学会

    ISSN： 0385-0307

  31. 乳がん手術前後の脳構造変化および認知機能障害 縦断研究による検討

    佐藤 千穂, 関口 敦, 事崎 由佳, 野内 類, 竹内 光, 瀧 靖之, 河合 賢朗, 多田 寛, 石田 孝宣, 川島 隆太, 大内 憲明

    心身医学　57　(7)　761-761　2017/07

    Publisher: (一社)日本心身医学会

    ISSN： 0385-0307

  32. 沿岸部被災地在住の高齢女性たちに対する園芸療法介入の効果の検証

    事崎 由佳, 竹内 光, 関口 敦, 荒木 剛, 山本 悠貴, 品田 貴光, Magistro Daniele, 十亀 彩, 瀧 靖之, 川島 隆太

    心身医学　57　(7)　761-762　2017/07

    Publisher: (一社)日本心身医学会

    ISSN： 0385-0307

  33. マインドフルネスによる食渇望制御とその神経基盤 fMRI研究

    村椿 智彦, 鹿野 理子, 関口 敦, 石垣 泰, 澤田 正二郎, 近藤 敬一, 事崎 由佳, 佐々木 彩加, 森下 城, 金澤 素, 片桐 秀樹, 川島 隆太, 福土 審

    心身医学　57　(7)　766-766　2017/07

    Publisher: (一社)日本心身医学会

    ISSN： 0385-0307

  34. Voxel-Based Morphometry and Cognitive Function

    Brain and nerve　69　(5)　547-556　2017/05

    Publisher: 医学書院

    ISSN： 1881-6096

  35. PRE-EXISTING SMALLER DLPFC VOLUME CONTRIBUTES TO POST-TRAUMATIC GROWTH AFTER A DISASTER IN CHILDREN

    Atsushi Sekiguchi, Yuka Kotozaki, Thyreau Benjamin, Hikaru Takeuchi, Susumu Yokota, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

    PSYCHOSOMATIC MEDICINE　79　(4)　A60-A61　2017/05

    ISSN： 0033-3174

    eISSN： 1534-7796

  36. Cortical activity during vocalization tuned to the pitch of the presented sound-magnetoencephalographic study using time-frequency analysis-

    NOMURA Yuri, KAWASE Tetsuaki, KANNO Akitake, NAKASATO Nobukazu, KAWASHIMA Ryuta, KATORI Yukio

    日本生体磁気学会誌　30　(1)　2017

    ISSN： 0915-0374

  37. Somatosensory evoked magnetic fields for the periodontal ligaments

    HIHARA Hiroki, KANETAKA Hiroyasu, KANNO Akitake, NAKASATO Nobukazu, KAWASHIMA Ryuta, SASAKI Keiichi

    日本生体磁気学会誌　30　(1)　2017

    ISSN： 0915-0374

  38. Somatosensory evoked responses in the cerebral cortex to periodontal ligament stimulation

    SHIMADA Eriya, KANETAKA Hiroyasu, KANNO Akitake, KANNO Akitake, KAWASHIMA Ryuta, NAKASATO Nobukazu, NAKASATO Nobukazu, IGARASHI Kaoru

    日本生体磁気学会誌　30　(1)　2017

    ISSN： 0915-0374

  39. A case of subclinical seizures uniquely detected by magnetoencephalography

    ISHIDA Makoto, KANNO Akitake, KANNO Akitake, KAKISAKA Yosuke, IWASAKI Masaki, JIN Kazutaka, KITAZAWA Yu, KAWASHIMA Ryuta, NAKASATO Nobukazu, NAKASATO Nobukazu

    日本生体磁気学会誌　30　(1)　2017

    ISSN： 0915-0374

  40. 「他者との憩い経験」の回想を通じた自尊心向上による妬みとシャーデンフロイデへの抑制効果のfMRIを用いた検証

    山崎翔平, 杉浦元亮, 河田(サントスケルシ)人美, 佐々木結咲子, 野内類, 榊浩平, 池田純起, 川島隆太

    日本ヒト脳機能マッピング学会プログラム・抄録集　19th　2017

  41. 大口蓋神経および舌神経電気刺激における大脳皮質反応の初期成分

    小枝 聡子, 日原 大貴, 菅野 彰剛, 川島 隆太, 中里 信和

    日本生体磁気学会誌　30　(1)　170-171　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  42. 大口蓋神経および舌神経電気刺激における大脳皮質反応の初期成分

    小枝 聡子, 日原 大貴, 菅野 彰剛, 川島 隆太, 中里 信和

    日本生体磁気学会誌　30　(1)　170-171　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  43. 身体リズム同調が教授・学習と脳活動同調に与える影響

    野澤孝之, 榊浩平, 山崎翔平, 河田サントスケルシ人美, 河田サントスナタシャ百合子, 佐々木結咲子, 池田純起, KULASON Kay, 平野香南, JEONG Hyeonjeong, 川島隆太

    計測自動制御学会システムインテグレーション部門講演会(CD-ROM)　17th　ROMBUNNO.1L4‐5　2016/12/15

  44. Neural Mechanisms and Children's Intellectual Development: Multiple Impacts of Environmental Factors

    Hikaru Takeuchi, Ryuta Kawashima

    NEUROSCIENTIST　22　(6)　618-631　2016/12

    DOI： 10.1177/1073858415610294 　

    ISSN： 1073-8584

    eISSN： 1089-4098

  45. MRI-BASED CBF ANALYSIS TO PREDICT FUNCTIONAL OUTCOME AFTER MURINE EXPERIMENTAL SAH

    Kazumasu Sasaki, Tatsushi Mutoh, Kazuhiro Nakamura, Ryuta Kawashima, Tatsuya Ishikawa

    CRITICAL CARE MEDICINE　44　(12)　2016/12

    ISSN： 0090-3493

    eISSN： 1530-0293

  46. 神経性やせ症患者の放線冠前部における白質線維統合性の低下

    佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 橋爪寛, 遠藤由香, 庄司知隆, 田村太作, 町田知美, 町田貴胤, 河内山隆紀, 瀧靖之, 川島隆太, 福土審, 福土審

    東北医学雑誌　128　(1)　64‐65　2016/06/25

    ISSN： 0040-8700

  47. Association between mu-opioid receptor gene variant 118 A &gt; G and personality traits among Japanese population

    Yumiko Kubo, Hikaru Takeuchi, Yoshie Kikuchi, Yoshiyuki Kasahara, Zhiqian Yu, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　19　299-300　2016/06

    ISSN： 1461-1457

    eISSN： 1469-5111

  48. 遊離前腕皮弁による舌再建術後の一次体性感覚誘発磁界反応

    菅野彰剛, 小枝聡子, 柿坂庸介, 中里信和, 中里信和, 川島隆太, 杉浦元亮

    日本生体磁気学会誌　29　(1)　90‐91-91　2016/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  49. Resting-State Connectivity between the MFC and right TPJ reflects a characteristic to avoid errors Peer-reviewed

    Miura N, Nozawa T, Takahashi M, Yokoyama R, Sasaki Y, Sakaki K, Kawashima R

    The 22st Annual Meeting of the Organization for Human Brain Mapping　2016/06

  50. 肥満症患者の灰白質容量とBMI、糖代謝指標との関係

    村椿 智彦, 鹿野 理子, 石垣 泰, 関口 敦, 澤田 正二郎, 近藤 敬一, 事崎 由佳, 佐々木 彩加, 森下 城, 金澤 素, 片桐 秀樹, 川島 隆太, 福土 審

    心身医学　56　(6)　607-607　2016/06

    Publisher: (一社)日本心身医学会

    ISSN： 0385-0307

  51. 側頭葉てんかん患者における術前MEG言語機能マッピング

    石田 誠, 岩崎 真樹, 菅野 彰剛, 神 一敬, 柿坂 庸介, 川島 隆太, 中里 信和

    日本生体磁気学会誌　29　(1)　128-129　2016/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  52. Erratum to Neural correlates of second-language communication and the effect of language anxiety [Neuropsychologia 66 (2015) 182-192], DOI: 10.1016/j.neuropsychologia.2014.11.013

    Hyeonjeong Jeong, Motoaki Sugiura, Wataru Suzuki, Yuko Sassa, Hiroshi Hashizume, Ryuta Kawashima

    Neuropsychologia　84　e1　2016/04

    DOI： 10.1016/j.neuropsychologia.2016.02.010 　

    ISSN： 0028-3932

    eISSN： 1873-3514

  53. 脳MRIを用いた初発乳癌術後半年の視床体積における神経可塑性の検討

    佐藤 千穂, 関口 敦, 河合 賢朗, 多田 寛, 石田 孝宣, 川島 隆太, 大内 憲明

    日本外科学会定期学術集会抄録集　116回　PS-012　2016/04

    Publisher: (一社)日本外科学会

  54. 肥満患者における視覚刺激による食渇望の誘導

    村椿 智彦, 石垣 泰, 金澤 素, 鹿野 理子, 森下 城, 関口 敦, 事崎 由佳, 川島 隆太, 片桐 秀樹, 福土 審

    心身医学　56　(3)　278-279　2016/03

    Publisher: (一社)日本心身医学会

    ISSN： 0385-0307

  55. MRI-based Non-invasive Assessment of Early Brain Injury and CBF for Functional Grading of Experimental Subarachnoid Hemorrhage in Mice

    Kazumasu Sasaki, Kazuhiko Nakamura, Tomoko Mutoh, Ryuta Kawashima, Tatsuya Ishikawa, Tatsushi Mutoh

    STROKE　47　2016/02

    ISSN： 0039-2499

    eISSN： 1524-4628

  56. 弁証法的問題解決の神経基盤の解明

    佐々木結咲子, 野澤孝之, 野澤孝之, 河田サントスケルシ人美, 池田純起, 榊浩平, 菊池達郎, 川島隆太, 川島隆太

    日本ヒト脳機能マッピング学会プログラム・抄録集　18th　82　2016

  57. 異文化接触による自己の再構築について―物語り論的視点に基づく海外留学推奨のための脳科学実験―

    長谷部正, 長谷部正, 伊藤航平, 杉浦元享, 木谷忍, 木暮悠太, 小山田晋, 朴壽永, 山本悠貴, 塙杉子, 野内類, 野澤孝之, ジョン ヒョンジョン, 川島隆太, 安江紘幸

    日本感性工学会大会予稿集(CD-ROM)　18th　ROMBUNNO.A53　2016

  58. 英語授業における脳活動同調評価の試み

    野澤孝之, 山本玲子, 石川保茂, JEONG Hyeonjeong, 池田純起, 榊浩平, 川島隆太

    計測自動制御学会システムインテグレーション部門講演会(CD-ROM)　16th　ROMBUNNO.2P3‐4　2015/12/14

  59. 側頭葉てんかん患者におけるMEG言語機能局在診断

    石田誠, 岩崎真樹, 菅野彰剛, 神一敬, 川島隆太, 中里信和

    てんかん研究　33　(2)　596-596　2015/09/17

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  60. Development of functional brain imaging modality by using animal 7T-MRI.

    Akira Sumiyoshi, Ryuta Kawashima

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica　146　(1)　40-6　2015/07

    DOI： 10.1254/fpj.146.40 　

  61. BCIによる脳・機械の相互適応の促進

    加納慎一郎, 川島隆太, 片山統裕, 三浦直樹

    芝浦工業大学特別教育・研究報告集(CD-ROM)　2014　55-58　2015/06/30

    ISSN： 2185-7326

  62. Neural bases of cognitive state which changes with own past behavior: an fMRI study Peer-reviewed

    Miura N, Nozawa T, Takahashi M, Yokoyama R, Sasaki Y, Sakaki K, Kawashima R

    The 21st Annual Meeting of the Organization for Human Brain Mapping　2015/06

  63. An fMRI study on implicit and explicit second language knowledge modulated by task types and proficiency level

    Jeong H, Ellis R, Suzuki W, Kashkouli Nejad K, Thyreau B, Magistro D, Yokoyama S, Kawashima R

    Proceedings of The 17th Annual International Conference of the Japanese Society for Language Sciences　162-163　2015/06

  64. 体性感覚誘発性棘波様活動を脳磁図で検出した成人てんかん3例

    石田 誠, 柿坂 庸介, 菅野 彰剛, 岩崎 真樹, 神 一敬, 川島 隆太, 中里 信和

    日本生体磁気学会誌　28　(1)　154-155　2015/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  65. 時間周波数解析による体性感覚誘発磁界反応の評価は遷延性意識障害患者の機能残存の評価に有用である

    菅野 彰剛, 中里 信和, 柿坂 庸介, 長嶺 義秀, 川島 隆太

    日本生体磁気学会誌　28　(1)　68-69　2015/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  66. その他 脳MRIを用いた乳がん手術後の脳構造変化および認知機能障害の検討

    佐藤 千穂, 関口 敦, 河合 賢朗, 多田 寛, 石田 孝宣, 川島 隆太, 大内 憲明

    日本外科学会定期学術集会抄録集　115回　OP-242　2015/04

    Publisher: (一社)日本外科学会

  67. 視覚情報提示による聴覚誘発磁界の変化 視覚情報提示のタイミングの影響について

    川瀬 哲明, 高田 志穂, 八幡 湖, 高梨 芳崇, 奥村 有理, 菅野 彰剛, 中里 信和, 川島 隆太, 香取 幸夫

    日本耳鼻咽喉科学会会報　118　(4)　564-564　2015/04

    Publisher: (一社)日本耳鼻咽喉科学会

    ISSN： 0030-6622

    eISSN： 1883-0854

  68. コミュニケーション手段の違いが脳活動に与える影響の評価

    野口茂明, 三浦直樹, 橋信, 川島隆太

    平成 27 年東北地区若手研究者研究発表会　2015/02

  69. 近赤外線分光法を用いた想定外事象に対峙したときの人間の脳活動解析

    千葉幹, 増山直幸, 三浦直樹, 橋信, 川島隆太

    平成 27 年東北地区若手研究者研究発表会　2015/02

  70. 脳磁図のみで発作活動が記録された外傷性てんかんの一例

    石田誠, 柿坂庸介, 神一敬, 岩崎真樹, 菅野彰剛, 加藤量広, 川島隆太, 中里信和

    てんかん研究　32　(3)　618-619　2015/01/31

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  71. 入浴環境の違いが脳活動に与える影響

    松下大剛, 佐藤稔, 加藤智久, 菅野彰剛, 横山諒一, 川島隆太

    日本感性工学会大会予稿集(CD-ROM)　17th　ROMBUNNO.B52　2015

  72. ピッチ認識を支える脳内神経基盤の解明

    王凱, 王凱, 菅野彰剛, 横山悟, 川島隆太

    日本ヒト脳機能マッピング学会プログラム・抄録集　17th　54　2015

  73. 交通外傷後持続的植物状態患者および最小意識状態患者における体性感覚誘発磁界反応

    菅野彰剛, 中里信和, 中里信和, 長嶺義秀, 川島隆太

    日本ヒト脳機能マッピング学会プログラム・抄録集　17th　51　2015

  74. 側頭葉てんかん患者におけるMEG言語マッピング

    石田誠, 岩崎真樹, 菅野彰剛, 神一敬, 川島隆太, 中里信和

    日本ヒト脳機能マッピング学会プログラム・抄録集　17th　68　2015

  75. Neural substrates representing temporal and motor sequences of rhythm

    Naho Konoike, Yuka Kotozaki, Jeong Hyeonjeong, Atsuko Miyazaki, Kohei Sakaki, Takamitsu Shinada, Motoaki Sugiura, Ryuta Kawashima, Katsuki Nakamura

    44th Annual meeting, Society for Neuroscience　2014/11

  76. てんかん治癒例における術前脳磁図

    石田誠, 岩崎真樹, 神一敬, 柿坂庸介, 加藤量広, 菅野彰剛, 川島隆太, 中里信和

    臨床神経生理学　42　(5)　289-289　2014/10/01

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  77. Brain training games improve cognitive functions in the healthy elderly

    野内類, 川島隆太

    高次脳機能研究　34　(3)　335-341　2014/09/30

    Publisher: Japan Society for Higher Brain Dysfunction

    DOI： 10.2496/hbfr.34.335 　

    ISSN： 1348-4818

    More details Close

    Our cognitive functions decline with age. Cognitive declines in the elderly may make it more difficult to do daily living and social behaviors. Consequently, many researchers are interested in developing methods to maintain and improve cognitive functions in the elderly. In this paper, we introduce simplified cognitive training such as reading aloud and simple calculation training (learning therapy) and training using brain training games. Our studies using a randomized controlled trial have reported that cognitive training can improve executive functions and processing speed in the healthy elderly. These results suggest that cognitive functions in the healthy elderly would be improved by cognitive training. We discuss future directions in a field of cognitivetraining using brain training game.

  78. Decreased cerebral blood flow and BDNF levels are associated with depression and memory impairment in patients with heart failure -Brain Assessment and Investigation in Heart Failure Trial (B-HeFT)-

    H. Suzuki, Y. Matsumoto, H. Ota, K. Sugimura, J. Takahashi, K. Ito, Y. Fukumoto, R. Kawashima, Y. Taki, H. Shimokawa

    EUROPEAN HEART JOURNAL　35　13-13　2014/09

    ISSN： 0195-668X

    eISSN： 1522-9645

  79. NIRS装置を用いたインタフェース評価に関する研究 (3)超小型NIRS装置によるインタフェース評価可能性の検討

    吉井慶人, 堀内友翔, 猪股礼寛, 三浦直樹, 高橋信, 川島隆太

    ヒューマンインタフェース2014　2014/09

  80. NIRS装置を用いたインタフェース評価に関する研究(2)超小型NIRS装置を用いた同時計測による評価

    小川剛史, 比嘉貴大, 堀内友翔, 三浦直樹, 高橋信, 川島隆太

    ヒューマンインタフェース2014　2014/09

  81. NIRS装置を用いたインタフェース評価に関する研究(1)遠隔コミュニケーションの評価

    渡邊琢磨, 秋澤由佳, 加納慎一郎, 高橋信, 三浦直樹, 川島隆太

    ヒューマンインタフェース2014　2014/09

  82. 舌電気刺激誘発脳磁界反応を用いた鼓索神経障害評価の可能性に関する検討

    高梨 芳崇, 川瀬 哲明, 菅野 彰剛, 八幡 湖, 奥村 有理, 山内 大輔, 中里 信和, 川島 隆太, 香取 幸夫

    Otology Japan　24　(4)　407-407　2014/09

    Publisher: (一社)日本耳科学会

    ISSN： 0917-2025

    eISSN： 1884-1457

  83. MINDFULNESS REDUCES CUE-INDUCED FOOD CRAVING: AN FMRI STUDY

    T. Murastubaki, S. Fukudo, M. Kano, A. Sekiguchi, Y. Ishigaki, S. Sawada, K. Kondo, Y. Kotozaki, A. Sasaki, J. Morishita, M. Kanazawa, H. Katagiri, R. Kawashima

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　21　S128-S128　2014/08

    ISSN： 1070-5503

    eISSN： 1532-7558

  84. アイロニー産出の脳メカニズム―脳磁図による検討―

    秋元頼孝, 菅野彰剛, 杉浦元亮, 佐々木結咲子, 横山諒一, 浅野孝平, 宮澤志保, 川島隆太

    日本心理学会大会発表論文集　78th　856　2014/08

  85. マインドフルネスと認知的再評価による食渇望制御とその神経基盤

    村椿 智彦, 鹿野 理子, 関口 敦, 石垣 泰, 事崎 由佳, 佐々木 彩加, 森下 城, 金澤 素, 片桐 秀樹, 川島 隆太, 福土 審

    心身医学　54　(6)　569-569　2014/06

    Publisher: (一社)日本心身医学会

    ISSN： 0385-0307

  86. Cognitive intervention through SAIDO Learning: A treatment for dementia. Peer-reviewed

    Sheryl L. Sereda, Deborah Hiller, Denise Gannon, Michelle Antonczak, Shinji Ito, Hiroshi Otake, Katsuki Nakamura, Masato Taira, Ryuta Kawashima, Stephanie Fallcreek

    29th International Conference of Alzheimer’s Disease International　2014/05

  87. 交通外傷後遷延性意識障害患者における体性感覚誘発磁界高周波振動

    菅野 彰剛, 中里 信和, 長嶺 義秀, 川島 隆太

    日本生体磁気学会誌　27　(1)　106-107　2014/05

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  88. マインドフルネスと認知的再評価による食渇望制御:fMRI研究

    村椿智彦, 鹿野理子, 石垣泰, 関口敦, 澤田正二郎, 近藤敬一, 事崎由佳, 佐々木彩加, 森下城, 金澤素, 片桐秀樹, 川島隆太, 福土審

    行動医学研究　20th　50　2014/03

    ISSN： 1341-6790

  89. Smart ageing : R&D for a prescription towards super ageing society

    KAWASHIMA Ryuta

    2014　(26)　3-3　2014/01/10

    Publisher: The Japan Society of Mechanical Engineers

  90. 潜在的購買意図形成の神経基盤

    横山諒一, 野澤孝之, 杉浦元亮, 蓬田幸人, 川島隆太

    日本ヒト脳機能マッピング学会プログラム・抄録集　16th　70　2014

  91. てんかん外科におけるMEG言語マッピング

    岩崎真樹, 菅野彰剛, 神一敬, 中里信和, 川島隆太, 冨永悌二

    日本ヒト脳機能マッピング学会プログラム・抄録集　16th　52　2014

  92. 被災地在住高齢女性への園芸介入による認知機能への影響

    事崎由佳, 竹内光, 関口敦, 瀧靖之, 川島隆太

    日本トラウマティック・ストレス学会大会プログラム・抄録集　13th　101　2014

  93. Neural correlates of simultaneous interpretation: The role of expertise and language proficiency Peer-reviewed

    Jeong H, Tatsumi K, Sugiura M, Kawashima R

    Proceedings of The 16th Annual International Conference of the Japanese Society for Language Sciences　171-172　2014

  94. 使える英語はコミュニケーション活動から【脳科学】授業に活かす言語学

    鄭嫣婷, 川島隆太

    英語教育　62　(10)　30-31　2013/12

  95. 脳磁図棘波の信号源推定を用いた外傷性てんかんの診断

    板橋泉, 神一敬, 岩崎真樹, 加藤量広, 板橋尚, 菅野彰剛, 冨永悌二, 川島隆太, 中里信和

    てんかん研究　31　(2)　458-458　2013/09/30

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  96. Structural abnormality of the hippocampus and depressive symptoms in a rat model of heart failure

    H. Suzuki, A. Sumiyoshi, Y. Matsumoto, T. Yoshikawa, Y. Fukumoto, K. Yanai, Y. Taki, R. Kawashima, H. Shimokawa

    EUROPEAN HEART JOURNAL　34　124-124　2013/08

    ISSN： 0195-668X

    eISSN： 1522-9645

  97. 過敏性腸症候群における情動制御の神経基盤の検討

    関口 敦, 杉浦 元亮, 川島 隆太, 事崎 由佳, 森下 城, 相沢 恵美子, 福土 審

    消化器心身医学　20　(1)　51-51　2013/08

    Publisher: 消化器心身医学研究会

    ISSN： 1340-8844

    eISSN： 2188-0549

  98. Learning foreign language vocabularies from communicative context: an fMRI study Peer-reviewed

    Jeong H, Sugiura M, Yokoyama S, Hashizume H, Takahashi K, Thyreau B, Suzuki W, Kawashima R

    Proceedings of The 15th Annual International Conference of the Japanese Society for Language Sciences　30-34　2013/07

  99. 非侵襲的脳機能画像法による自発的な模倣の駆動に関わる神経基盤

    塙杉子, 杉浦元亮, 事崎由佳, 出江紳一, 川島隆太

    日本作業療法学会抄録集(CD-ROM)　47回　O181-O181　2013/06

    Publisher: (一社)日本作業療法士協会

    ISSN： 1880-6635

  100. 震災後精神症状の脆弱性・獲得因子の神経基盤の解明

    関口 敦, 杉浦 元亮, 事崎 由佳, 佐久間 篤, 瀧 靖之, 川島 隆太

    トラウマティック・ストレス　11　(1)　63-67　2013/06

    Publisher: 日本トラウマティック・ストレス学会 ; 2003-

    ISSN： 1348-0944

  101. 東日本大震災被災地在住の軽度PTSD症状の高齢女性たちに対する園芸療法介入

    事崎由佳, 竹内光, 関口敦, 荒木剛, 山本悠貴, 品田貴光, MAGISTRO Daniele, 十亀彩, 瀧靖之, 川島隆太

    日本トラウマティック・ストレス学会大会プログラム・抄録集　12th　112　2013/05/10

  102. 震災前後に認められた脳形態変化の追跡調査

    関口敦, 事崎由佳, 杉浦元亮, 塙杉子, 中川誠秀, 宮内カルロス誠, 佐久間篤, 瀧靖之, 川島隆太

    日本トラウマティック・ストレス学会大会プログラム・抄録集　12th　114　2013/05/10

  103. PS-138-1 乳癌患者における術後認知機能障害の神経基盤の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    佐藤 千穂, 関口 敦, 河合 賢朗, 多田 寛, 石田 孝宣, 川島 隆太, 大内 憲明

    日本外科学会雑誌　114　(2)　709-709　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  104. PS-138-1 乳癌患者における術後認知機能障害の神経基盤の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    佐藤 千穂, 関口 敦, 河合 賢朗, 多田 寛, 石田 孝宣, 川島 隆太, 大内 憲明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  105. Relationship between brain anatomy and an ability of non-native speech sound production in school children

    HASHIZUME Hiroshi, TAKI Yasuyuki, THYREAU Benjamin, SASSA Yuko, ASANO Michiko, ASANO Kohei, TAKEUCHI Hikaru, JEONG Hyeonjeong, SUGIURA Motoaki, KAWASHIMA Ryuta

    日本神経化学会大会抄録集(Web)　56th　2013

  106. 健常成人における性格と局所灰白質体積減少速度との相関

    瀧靖之, THYREAY Thyreau, 木之村重男, 佐藤和則, 後藤了以, 川島隆太, 福田寛

    日本老年医学会雑誌　50　(5)　2013

    ISSN： 0300-9173

  107. 神経性食思不振症患者の意思決定時における背外側前頭前皮質の活動亢進

    佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 瀧靖之, 橋爪寛, 河内山隆紀, 川島隆太, 福土審

    日本摂食障害学会学術集会プログラム・講演抄録集　17th　116　2013

  108. Signal delivery to the brain using optogenetics

    T. Honjoh, Z-G. Ji, Y. Yokoyama, A. Sumiyoshi, T. Ishizuka, R. Kawakshima, H. Yawo

    Reports on The 437th Topical Meeting of The Laser Society of Japan - Neurophotonics　15-19　2012/12

  109. 脳磁図を用いた聴覚性言語記憶課題による言語優位半球同定

    菅野彰剛, 中里信和, 川島隆太

    臨床神経生理学　40　(5)　410-410　2012/10/01

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  110. 被災地在住の軽度PTSD症状の女性に対する園芸介入

    事崎由佳, 荒木剛, 川島隆太

    日本心理学会大会発表論文集　76回　347-347　2012/08

    Publisher: (公社)日本心理学会

    eISSN： 2433-7609

  111. The relationship between developmental changes in pronunciation and brain activity during speech production in a foreign language

    HASHIZUME Hiroshi, TAKI Yasuyuki, SASSA Yuko, THYREAU Benjamin, ASANO Michiko, ASANO Kohei, TAKEUCHI Hikaru, NOUCHI Rui, KOTOZAKI Yuka, JEONG Hyeonjeong, SUGIURA Motoaki, KAWASHIMA Ryuta

    Technical report of IEICE. Thought and language　112　(145)　19-23　2012/07/14

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    Childhood is known to be the best time in life to acquire foreign speech sounds. Therefore, it is important for foreign language education to clarify the neural process relating to foreign speech sounds. Healthy right-handed children (aged 6-18 years) participated in this study. Using functional magnetic resonance imaging, we examined their brain activation during an overt repetition and perceptual task with native and non-native syllables. The results showed that brain activation in the left inferior frontal gyrus pars opercularis, which is thought to be involved in motor control for speech production, increased with age. Additionally, accuracy of the pronunciation of non-native syllables improved with age. Those results indicate that improvement in foreign speech pronunciation might reflect maturation of the left inferior frontal gyrus.

  112. Brain development using magnetic resonance imaging in healthy children

    TAKI Yasuyuki, KAWASHIMA Ryuta

    小児の脳神経　37　(3)　223-231　2012/06/30

    ISSN： 0387-8023

  113. 標準脳へのspike mapping tool てんかんMEGの多角的分析を目指して

    奥村 栄一, 岩崎 真樹, 菅野 彰剛, 神 一敬, 板橋 尚, 大沢 伸一郎, 加藤 量広, 川島 隆太, 中里 信和

    日本生体磁気学会誌　25　(1)　104-105　2012/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  114. 小さな皮質形成異常に伴うてんかん棘波の信号源推定

    板橋 尚, 神 一敬, 岩崎 真樹, 奥村 栄一, 菅野 彰剛, 加藤 量広, 冨永 悌二, 川島 隆太, 永井 敏郎, 中里 信和

    日本生体磁気学会誌　25　(1)　106-107　2012/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  115. 脳磁図解析法 グループ解析

    菅野 彰剛, 秋元 頼孝, 神原 利宗, 杉浦 元亮, 奥村 栄一, 中里 信和, 川島 隆太

    日本生体磁気学会誌　25　(1)　56-57　2012/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  116. 学習意欲の発達的変化と生活環境の影響

    荒木剛, 杉浦元亮, 筒井健一郎, 池田和浩, 川島隆太

    日本発達心理学会大会論文集　23rd　477　2012/02/01

  117. A GO intervention program for enhancing elementary school children's cognitive functions and control abilities of emotion and behavior: Study protocol for a randomized controlled trial International-journal

    Yoshiyuki Tachibana, Jiro Yoshida, Masahito Ichinomiya, Rui Nouchi, Carlos Miyauchi, Hikaru Takeuchi, Naoki Tomita, Hiroyuki Arai, Ryuta Kawashima

    Trials　13　8-8　2012/01/12

    DOI： 10.1186/1745-6215-13-8 　

  118. ヒト脳の正常発達・加齢に伴う脳形態およびネットワーク構造の変化-健常日本人脳MR画像データベースを用いた画像医学的研究

    福田寛, 瀧靖之, WU Kai, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 秋本達也, 川島隆太

    ナノ医工学年報2011 東北大学グローバルCOEプログラム 新世紀世界の成長焦点に築くナノ医工学拠点　2012

  119. 健常成人の加齢における局所脳灰白質量の減少-383人の脳MRI解析による縦断研究-

    瀧靖之, 木之村重男, 佐藤和則, 後藤了以, WU Kai, 川島隆太, 福田寛

    日本老年医学会雑誌　49　(5)　2012

    ISSN： 0300-9173

  120. 健常成人の高感度C反応性蛋白と局所脳灰白質量との相関

    瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 福田寛, 川島隆太

    日本医学放射線学会総会抄録集　71st　2012

    ISSN： 0048-0428

  121. Neural substrates for maintenance of rhythm information Peer-reviewed

    Konoike N, Kotozaki Y, Miyachi S, Miyauchi CM, Yomogida Y, Akimoto Y, Kuraoka K, Sugiura M, Kawashima R, Nakamura K

    The 35th Annual Meeting of the Japan Neuroscience Society (2012/09-18-21, Nagoya)　2012

  122. 東日本大震災被災地在住のMild‐PTSD症状の女性たちに対する園芸療法介入

    事崎由佳, 竹内光, 関口敦, 荒木剛, 川島隆太

    日本トラウマティック・ストレス学会大会プログラム・抄録集　11th　98　2012

  123. 震災後精神症状の脆弱性/獲得因子の神経基盤の解明

    関口敦, 杉浦元亮, 事崎由佳, 佐久間篤, 川島隆太

    日本トラウマティック・ストレス学会大会プログラム・抄録集　11th　101　2012

  124. 神経性食思不振症患者の意思決定機能の脳機能画像的検討

    佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 瀧靖之, 橋爪寛, 河内山隆紀, 川島隆太, 福土審

    日本摂食障害学会学術集会プログラム・講演抄録集　16th　77　2012

  125. Evidence for Different Brain Processing from the Left and the Right Ventricles by Brain Functional MRI in Rats

    Hideaki Suzuki, Akira Sumiyoshi, Ryuta Kawashima, Hiroaki Shimokawa

    CIRCULATION　124　(21)　2011/11

    ISSN： 0009-7322

  126. Can you train your brain functions by mastication?

    KAWASHIMA Ryuta

    18　(1)　1-5　2011/10/30

    ISSN： 1340-9085

  127. Procrastination from Individual difference in Subjective Well-Being

    KOTOZAKI Yuka, Nozawa Takayuki, Kawashima Ryuta

    The Proceedings of the Annual Convention of the Japanese Psychological Association　75回　(0)　651-651　2011/08

    Publisher: The Japanese Psychological Association

    DOI： 10.4992/pacjpa.75.0_1EV068 　

    eISSN： 2433-7609

  128. 学習によって変化する語と感覚情報の連合に関与する神経基盤の解明 Peer-reviewed

    神原利宗, 月浦 崇, 重宗弥生, 野内類, 蓬田幸人, 菅野彰剛, 川島隆太

    言語科学会第13回年次国際大会 (JSLS 2011), 大阪　2011/06

  129. 383人の健常成人の縦断研究による加齢及び脳血管障害危険因子と局所脳灰白質体積減少量との相関

    瀧靖之, 木之村重男, 佐藤和則, 後藤了以, WU Kai, 川島隆太, 福田寛

    日本医学放射線学会総会抄録集　70th　2011

    ISSN： 0048-0428

  130. ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化-健常日本人脳MR画像データベースを用いた画像医学的研究

    福田寛, 滝靖之, WU Kai, 木之村重男, 佐藤和則, 井上健太郎, 後藤了以, 岡田賢, 川島隆太

    ナノ医工学年報2010 東北大学グローバルCOEプログラム 新世紀世界の成長焦点に築くナノ医工学拠点　2011

  131. 中国・日本科学最前線-研究の現場から-2011年版 医療における診断技術の研究開発「医療における診断技術の研究開発」-脳磁図の臨床応用

    川島隆太, 川島隆太, 菅野彰剛

    中国・日本科学最前線-研究の現場から 2011年版　2011

  132. Sparse and heterogeneous codification of sound attributes in rat primary auditory cortex revealed by laminar profile analysis

    Takeshi Ogawa, Takakuni Goto, Akira Sumiyoshi, Hiroi Nonaka, Karim Jerbi, Olivier Bertrand, Ryuta Kawashima, Jorge Riera

    NEUROSCIENCE RESEARCH　71　E149-E150　2011

    DOI： 10.1016/j.neures.2011.07.645 　

    ISSN： 0168-0102

  133. Gender differences in partial-volume corrected brain perfusion using brain MRI in healthy children

    Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Wu Kai, Rui Nouchi, Yuka Kotozaki, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　71　E388-E388　2011

    DOI： 10.1016/j.neures.2011.07.1701 　

    ISSN： 0168-0102

  134. Sex difference in correlation between cognitive style and brain activity during visual delayed matching to sample task in children

    Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　71　E387-E388　2011

    DOI： 10.1016/j.neures.2011.07.1700 　

    ISSN： 0168-0102

  135. Localization of single barrel column by means of a volumetric current source density analysis in the somatosensory cortex of rat

    Takakuni Goto, Takeshi Ogawa, Jorge Riera, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　71　E304-E305　2011

    DOI： 10.1016/j.neures.2011.07.1328 　

    ISSN： 0168-0102

  136. The overlapping community structure of structural brain network in young healthy individuals.

    Wu Kai, Taki Yasuyuki, Sato Kazunori, Sassa Yuko, Inoue Kentaro, Goto Ryoi, Okada Ken, Kawashima Ryuta, He Yong, Evans Alan C, Fukuda Hiroshi

    PLoS One　6　(5)　e19608-e19608　2011

    DOI： 10.1371/journal.pone.0019608 　

    ISSN： 1932-6203

  137. Lexical Categories and the Human Brain: An fMRI Study

    Kambara T, S. Yokoyama, K. Takahashi, N. Miura, T. Miyamoto, D. Takahashi, S. Sato, R. Kawashima

    Studies in Language Sciences　10　187-199　2011

  138. Neural substrates of intention comprehension of verbal irony:: an fMRI study

    AKIMOTO Yoritaka, SUGIURA Motoaki, YOMOGIDA Yukihito, MIYAUCHI Makoto Carlos, MIYAZAWA Shiho, KAWASHIMA Ryuta

    The Proceedings of the Annual Convention of the Japanese Psychological Association　75　(0)　3AM137-3AM137　2011

    Publisher: 公益社団法人 日本心理学会

  139. Different contributions of frontal, parietal, and temporal cortices to working memory of rhythm. Peer-reviewed

    Konoike N, Kotozaki Y, Miyachi S, Miyachi CM, Yomogida Y, Akimoto Y, Kuraoka K, Sugiura M, Kawashima R, Nakamura K

    41th Annual meeting, Society for Neuroscience (2011/11, Washington, DC).　2011

  140. Analysis of Normal Brain Aging using Brain MRI Database of Japanese Subjects

    FUKUDA Hiroshi, TAKI Yasuyuki, Wu Kai, KAWASHIMA Ryuta

    IEICE technical report.　110　(195)　61-64　2010/08/27

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    Age-related change of the brain was analyzed using MRI database of the 2,500 Japanese subjects. The gray matter volume decreased with age, while white matter volume increased with age until age of 50 and then went down. Longitudinal study in 383 subjects who received the second MRI with 7 year-interval revealed that the gray matter volume decline was slower in women than that in men. Standard brain for each age and sex group was calculated using anatomical standardization technique. The brain network analysis based on graph theory using regional gray matter volume exhibited &quot;small-world&quot; property and modular structure. The parameters for them were different among young, middle and old group.

  141. 報酬と罰がエピソード記憶の想起に与える影響(Effects of monetary reward and punishment on neural activations during successful retrieval of source memories)

    重宗 弥生, 月浦 崇, 神原 利宗, 川島 隆太

    神経化学　49　(2-3)　486-486　2010/08

    Publisher: 日本神経化学会

    ISSN： 0037-3796

  142. The Stress reduction effect by a Biofeedback training for Workers

    KOTOZAKI Yuka, OGINO Takeshi, KAWASHIMA Ryuta

    The Proceedings of the Annual Convention of the Japanese Psychological Association　74回　(0)　1297-1297　2010/08

    Publisher: The Japanese Psychological Association

    DOI： 10.4992/pacjpa.74.0_1PM020 　

    eISSN： 2433-7609

  143. 274人の健常小児を対象にした、年齢と灰白質体積との相関(Relationship between gray matter volume and age in 274 healthy Japanese children applying voxel-based morphometric analysis)

    瀧 靖之, 橋爪 寛, 佐々 祐子, 竹内 光, Kai Wu, 野内 類, 事崎 由佳, 浅野 孝平, 浅野 路子, 福田 寛, 川島 隆太

    神経化学　49　(2-3)　484-484　2010/08

    Publisher: 日本神経化学会

    ISSN： 0037-3796

  144. 人物に関する記憶の記銘時の神経活動に対する加齢の効果(Age-related differences in brain activity during successful encoding of memory for person identity information)

    月浦 崇, 重宗 弥生, 神原 利宗, 関口 敦, 蓬田 幸人, 中川 誠秀, 秋月 祐子, 瀧 靖之, 川島 隆太

    神経化学　49　(2-3)　664-664　2010/08

    Publisher: 日本神経化学会

    ISSN： 0037-3796

  145. 側頭頭頂領域における視覚的社会情報処理の機能解剖(Functional anatomy of visuosocial processing in temporo-parietal region)

    杉浦 元亮, 蓬田 幸人, 間野 陽子, 佐々 祐子, 神原 利宗, 関口 敦, 川島 隆太

    神経化学　49　(2-3)　749-749　2010/08

    Publisher: 日本神経化学会

    ISSN： 0037-3796

  146. Age-dependency in brain activation involved with imitation of unfamiliar foreign language sound: an fMRI study

    HASHIZUME HIROSHI, TAKI YASUYUKI, SASSA YUKO, ASANO MICHIKO, ASANO KOHEI, TAKEUCHI HIKARU, JEONG HYEONJEONG, SUGIURA MOTOAKI, KAWASHIMA RYUTA

    神経化学　49　(2/3)　664　2010/08/01

    ISSN： 0037-3796

  147. Cortical activity with reflexological stimulation is unaffected by pseudo information: An fMRI study, Peer-reviewed

    Miura N, Akitsuki Y, Sekiguchi A, Kawashima R

    16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona,　2010/06

  148. Neural activations associated with the effect of monetary rewards on intrinsic motivation Peer-reviewed

    Miki K, Sekiguchi A, Sugiura M, Akitsuki Y, Tsukiura T, Yomogida Y, Kawashima R

    16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain　2010/06

  149. ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化-健常日本人脳MR画像データベースを用いた画像医学的研究

    福田寛, 滝靖之, WU Kai, 木之村重男, 佐藤和則, 井上健太郎, 後藤了以, 岡田賢, 川島隆太

    ナノ医工学年報2009 東北大学グローバルCOEプログラム 新世紀世界の成長焦点に築くナノ医工学拠点　2010

  150. Effects of monetary reward and punishment on neural

    Yayoi Shigemune, Takashi Tsukiura, Toshimune Kambara, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　68　E69-E69　2010

    DOI： 10.1016/j.neures.2010.07.070 　

    ISSN： 0168-0102

  151. IMPROVING COGNITIVE FUNCTIONS OF SENIORS BY READING AND SOLVING ARITHMETIC PROBLEMS Peer-reviewed

    K. Nakamura, M. Taira, R. Kawashima

    EUROPEAN PSYCHIATRY　25　2010

    ISSN： 0924-9338

  152. 有効視野拡大訓練に伴う脳活動の変化

    西村聡生, 月浦崇, 荻谷光晴, 木村賢治, 飯島敏夫, 川島隆太, 塩入諭, 筒井健一郎

    基礎心理学研究　28　(2)　2010

    ISSN： 0287-7651

  153. Relationship between gray matter volume and age in 274 healthy Japanese children applying voxel-based morphometric analysis

    Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Wu Kai, Rui Nouchi, Yuka Kotozaki, Kohei Asano, Michiko Asano, Hiroshi Fukuda, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　68　E65-E66　2010

    DOI： 10.1016/j.neures.2010.07.056 　

    ISSN： 0168-0102

  154. A critical view of the dipolar model in the neocortex

    Jorge Riera, Takakuni Goto, Takeshi Ogawa, Akira Sumiyoshi, Hiroi Nonaka, Akitake Kanno, Kazuyuki Kose, Hiroyoshi Miyakawa, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　68　E331-E331　2010

    DOI： 10.1016/j.neures.2010.07.1469 　

    ISSN： 0168-0102

  155. Correlation between cognitive style and brain activity in visual delayed matching task in children

    Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　68　E295-E296　2010

    DOI： 10.1016/j.neures.2010.07.1312 　

    ISSN： 0168-0102

  156. A volumetric current source density analysis with realistic geometrical properties and conductivity profiles in the somatosensory cortex of rats

    Takakuni Goto, Takeshi Ogawa, Jorge Riera, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　68　E440-E440　2010

    DOI： 10.1016/j.neures.2010.07.1949 　

    ISSN： 0168-0102

  157. Effect of NIRS-based neurofeedback on brain activity during motor imagery : Evaluation by fMRI measurement

    SUSILA I Putu, KANOH Shin'ichiro, MIYAMOTO Ko-ichiro, YOSHINOBU Tatsuo, KAWASHIMA Ryuta

    IEICE technical report. Neurocomputing　109　(280)　65-70　2009/11/05

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    In this study, the effect of neurofeedback training on brain activity during motor imagery was evaluated by functional magnetic resonance imaging (fMRI). The training was performed for 5 days using near-infrared spectroscopy (NIRS). During training sessions, feedback information was extracted from the brain activity which was measured online while users performed motor imagery of right hand. On 3 out of 5 subjects, brain activations at supplementary motor area (SMA), primary motor area (M1) and cerebellum were localized after training. Furthermore, analysis of BOLD signal in specific volume of interests (VOIs) showed that peak and integral values during motor imagery became smaller after training on 2 of these 3 subjects. In contrast, it was shown by our NIRS study that the integral values of oxy-hemoglobin signal measured by NIRS during motor imagery on these 3 subjects were increased after feedback training.

  158. Effect of NIRS-based neurofeedback on brain activity during motor imagery : Evaluation by NIRS measurement

    IIZUKA Kei, KANOH Shin'ichiro, MIYAMOTO Ko-ichiro, YOSHINOBU Tatsuo, KAWASHIMA Ryuta

    IEICE technical report. Neurocomputing　109　(280)　59-64　2009/11/05

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    The authors have evaluated the effect of neurofeedback training for subjects on the brain activity to be used in the brain-computer interface (BCI) which detected motor imagery from cerebrum blood flow measured by NIRS (near-infrared spectroscopy). The concentrations of oxy-hemoglobin on motor cortex during motor imagery of a subject's right hand were measured, and were visually fed back to the subject. It was shown that the training enhanced the cerebral blood flow during motor imagery on two out of five subjects. Investigation of more effective training and neurofeedback methods were left for the further study.

  159. Effects of aging on anterior temporal and hippocampal activations during successful retrieval of memory for person identity information Peer-reviewed

    Tsukiura T, Sekiguchi A, Yomogida Y, Nakagawa S, Akitsuki Y, Taki Y, Kawashima R

    The 39th Annual Meeting of Society for Neuroscience, Chicago, USA　2009/10

  160. Anatomy of episodic context: distinct neural bases for item-roles and item integration Peer-reviewed

    Sugiura M, Yomogida Y, Mano Y, Kambara T, Sekiguchi A, Tsukiura T, Kawashima R

    The 39th Annual Meeting of Society for Neuroscience, Chicago, USA　2009/10

  161. Neural correlates of social interaction and concern for other person in episodic memory: an fMRI study Peer-reviewed

    間野陽子, 杉浦元亮, 月浦 崇, 蓬田幸人, ジョンヒョンジョン, 関口 敦, 秋月祐子, 川島隆太

    第32回日本神経科学学会総会，名古屋　2009/09

  162. エピソード記憶におけるソーシャル・インタラクションの影響:fMRI研究

    MANO YOKO, SUGIURA MOTOAKI, TSUKIURA TAKASHI, YOMOGIDA YUKIHITO, JEONG HYEONJEONG, SEKIGUCHI ATSUSHI, AKITSUKI YUKO, KAWASHIMA RYUTA

    日本心理学会大会発表論文集　73rd　546　2009/08

  163. Pulse wave velocity (PWV) と Cardio Ankle Vascular Index (CAVI) ―数理モデルから臨床、予防医学への展開―

    山家智之, 白石泰之, 今野 敏, 劉 紅箭, 川島隆太, 吉澤 誠, 早瀬敏幸, 阿部恒之, ビクター・ミラーゲン, ユーリ・コバレフ, イリーナ・ミリャジーナ, 侯 暁彫, 張 秀敏

    日本臨床生理学会雑誌　39　(4)　189-213　2009/07

    Publisher: 日本臨床生理学会

  164. Contribution of the bilateral middle temporal gyri to the processing of lexical categories

    Tachibana K, Suzuki K, Mori E, Miura N, Kawashima R, Horie K, Sato S, Tanji J, Muchiake H

    The annual meeting of the cognitive science society　2009/07

  165. A Brain-Computer Interface (BCI) System Based on Motor Imagery by NIRS Measurement : System Development and Online Feedback Training

    KANOH Shin'ichiro, MURAYAMA Yu-mi, MIYAMOTO Ko-ichiro, YOSHINOBU Tatsuo, KAWASHIMA Ryuta

    IEICE technical report　108　(480)　375-380　2009/03/04

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    A brain-computer interface (BCI) which detected motor imagery from cerebrum blood flow measured by NIRS (near-infrared spectroscopy) was constructed and the effect of online feedback training for subjects was evaluated. Concentrations of oxy-hemoglobin in motor cortex during motor imagery of subject's right hand was measured by 52 channel NIRS system, and mean magnitude of measured signal near C3 in international 10-20 system was visually fed back online to subject. It was shown that the signal-to-noise ratio of blood flow level elicited by imagery of subject's right hand was improved by online feedback training for five days. Investigation of the detailed effect of feedback training to the change of brain activities related to motor imagery was left for further study.

  166. Emergence of Control Skill : Learning and Acquisition Process of Movement Control Under Autonomous Constraint

    GOTO Takakuni, HOMMA Noriyasu, KAWASHIMA Ryuta

    48　(1)　100-105　2009/01/10

    Publisher: 計測自動制御学会

    ISSN： 0453-4662

  167. 年齢相応の脳発達とは?

    瀧靖之, 橋爪寛, 佐々祐子, 木之村重男, 後藤了以, 佐藤和則, 福田寛, 川島隆太

    日本医学放射線学会総会抄録集　68th　2009

    ISSN： 0048-0428

  168. Developmental neural networks in children performing Go/NoGo task: an fMRI study with wide age range

    Hiroshi Hashizume, Yasuyuki Taki, Yuko Sassa, Michiko Asano, Kohei Asano, Hikaru Takeuchi, Mijin Lee, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　65　S240-S240　2009

    DOI： 10.1016/j.neures.2009.09.1359 　

    ISSN： 0168-0102

  169. Voxel-based morphometry of the relationships between Intelligence Quotient and brain gray matter volume in 156 healthy Japanese children

    Michiko Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kohei Asano, Mijin Lee, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　65　S226-S226　2009

    DOI： 10.1016/j.neures.2009.09.1262 　

    ISSN： 0168-0102

  170. alpha 2*NICOTINIC ACETHYLCHOLINE RECEPTORS AND LTP INDUCTION IN THE HIPPOCAMPAL CA1 REGION

    Sakura Nakauchi, Jorge Riera, Ryuta Kawashima, Katumi Sumikawa

    JOURNAL OF PHYSIOLOGICAL SCIENCES　59　186-186　2009

    ISSN： 1880-6546

  171. Correlation between brain activity during delayed matching task and verbal IQ in healthy children

    Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Michiko Asano, Mijin Lee, Hikaru Takeuchi, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　65　S241-S241　2009

    DOI： 10.1016/j.neures.2009.09.1360 　

    ISSN： 0168-0102

  172. Relationship between gray matter volume and age in 156 healthy Japanese children: Volumetric analysis and voxel-based morphometry

    Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Mijin Lee, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　65　S225-S225　2009

    DOI： 10.1016/j.neures.2009.09.1261 　

    ISSN： 0168-0102

  173. Brain Science and Society

    KAWASHIMA R.

    120　(2)　165-168　2008/12/25

    Publisher: 東北医学会

    ISSN： 0040-8700

  174. Development of a Brain-Computer Interface using Selective Auditory Evoked Hemodynamic Response

    SAIKA Hiroki, MIURA Naoki, KAWASHIMA Ryuta, WANG Shuoyu

    電気学会研究会資料. MBE, 医用・生体工学研究会　2008　(49)　31-34　2008/10/24

  175. A Relationship between Brain and Muscle Activity : A functional Near Infrared Spectroscopy Study

    AMANO Keisuke, MIURA Naoki, KAWASHIMA Ryuta, WANG Shuoyu

    電気学会研究会資料. MBE, 医用・生体工学研究会　2008　(49)　63-66　2008/10/24

  176. A Relationship between Brain and Muscle Activity : A functional Near Infrared Spectroscopy Study

    AMANO Keisuke, MIURA Naoki, KAWASHIMA Ryuta, WANG Shuoyu

    IEICE technical report　108　(264)　117-120　2008/10/16

    Publisher: 一般社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    Recently, an importance of neurorehabilitation based on findings of the brain plasticity has been widely recognized. In the present study, to apply a finding of the neuroscientific evidences for rehabilitation by walking, we measured changes in regional cerebral blood flow (rCBF) during changing the posture, from sitting position to standing up, by a functional Near Infrared Spectroscopy, and compare those in rCBF with muscle activities of legs and lower abdomen measured by electromyography. From the results, a relationship between changes of rCBF on medial sensorymotor cortex and muscle activities of legs was observed during changing the posture.

  177. Development of a Brain-Computer Interface using Selective Auditory Evoked Hemodynamic Response

    SAIKA Hiroki, MIURA Naoki, KAWASHIMA Ryuta, WANG Shuoyu

    IEICE technical report　108　(264)　85-88　2008/10/16

    Publisher: 一般社団法人電子情報通信学会

    ISSN： 0913-5685

    More details Close

    In order to develop a Brain-Computer Interface (BCI) based on auditory evoked hemodynamic response, we measured brain activity during listening to a song using Near Infrared Spectroscopy (NIRS). Subjects were asked to switch their attention towards a lyrics or melody of the song during NIRs measurements, and the different hemodynamic response patterns, which can be used for BCI control signals, in the bilateral auditory cortices were obtained.

  178. Functional Organization of the Human Brain Involved in Safety Driving

    KAWASHIMA Ryuuta

    62　(7)　4-5　2008/07/01

    ISSN： 0385-7298

  179. fMRIを用いた知的興奮に関する脳ネットワークの同定

    福島愛, 杉浦元亮, 三浦直樹, 内田信也, 川島隆太

    第10回日本ヒト脳機能マッピング学会　2008/06

  180. An fMRI Study of Word Category on Word Recognition Peer-reviewed

    Kambara T, Yokoyama S, Takahashi K, Miura N, Miyamoto T, Takahashi D, Sato S, Kawashima R

    14th Annual Meeting of the Organization for Human Brain Mapping　2008/06

  181. An fMRI Study of syntactic information on word recognition Peer-reviewed

    Kambara T, Yokoyama S, Takahashi K, Miura N, Miyamoto T, Takahashi D, Sato S, Kawashima R

    14th Annual Meeting of the Organization for Human Brain Mapping　2008/06

  182. FMRI study on risk perception for driving task presented as video images Peer-reviewed

    Takahashi M, Aboshi T, Miura N, Ota H, Kawashima R, Wakabayashi T

    14th Annual Meeting of the Organization for Human Brain Mapping　2008/06

  183. Top-down facilitation of visual object recognition Peer-reviewed

    Taminato T, Miura N, Sugiura M, Kawashima R

    14th Annual Meeting of the Organization for Human Brain Mapping　2008/06

  184. A somatotopical relationship between cortical activity and reflexological stimulation: an fMRI study Peer-reviewed

    Nakamaru T, Miura N, Fukushima A, Kawashima R

    14th Annual Meeting of the Organization for Human Brain Mapping　2008/06

  185. The effect of body structure of humanoid robot for emotional empathy: an fMRI study Peer-reviewed

    Miura N, Sugiura M, Takahashi M, Moridaira T, Miyamoto A, Kuroki Y, Kawashima R

    14th Annual Meeting of the Organization for Human Brain Mapping　2008/06

  186. The action of bipedal humanoid robot strongly induces emotional brain responses: a neuroimaging approach Peer-reviewed

    Miura N, Sugiura M, Takahashi M, Moridaira T, Miyamoto A, Kuroki Y, Kawashima R

    3rd ACM/IEEE International Conference on Human-Robot Interaction　2008/03

  187. 語彙認知過程における修飾情報と叙述情報の脳内処理

    神原利宗, 横山悟, 高橋慶, 三浦直樹, 宮本正夫, 高橋大厚, 佐藤滋, 川島隆太

    言語処理学会第14回年次大会　2008/03

  188. 加齢による灰白質体積の減少は男性が女性よりも早い-382人の脳MRI解析による縦断研究-

    瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

    日本医学放射線学会総会抄録集　67th　2008

    ISSN： 0048-0428

  189. Astrocytic Ca2+ waves and sustained functional hyperemia

    Jorge Riera, H. G. Enjieu Kadji, Takeshi Ogawa, Morito Rieke, Takakuni Goto, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　61　S49-S49　2008

    ISSN： 0168-0102

  190. Microscopic conductivity profile in the cerebral cortex of Wistar rats

    Takakuni Goto, Takeshi Ogawa, H. G. Enjieu Kadji, Ryuta Kawashima, Jorge Riera

    NEUROSCIENCE RESEARCH　61　S140-S140　2008

    ISSN： 0168-0102

  191. Lexicall Processing of Modification and Predication

    神原利宗, 横山悟, 高橋慶, 三浦直樹, 宮本正夫, 高橋大厚, 佐藤滋, 川島隆太

    言語処理学会第14回年次大会発表論文集　B5-8　1061-1064　2008

  192. 内容語の語彙情報に関するfMRI手法を用いた脳科学的分析

    神原利宗, 横山悟, 高橋慶, 三浦直樹, 宮本正夫, 高橋大厚, 佐藤滋, 川島隆太

    言語科学会第10回年次国際大会JSLS2008論文集　JSLS2008　81-84　2008

  193. Neural mechanisms underlying a face-to-face interview in the second language Peer-reviewed

    Jeong H, Hashizume H, Sassa Y, Yokoyama S, Nakamura K, Sugiura M, Kawashima R

    Neuroscience Research　61　(Supplement 1)　S199　2008

  194. Cortical mechanism of ideal self _ an fMRI study Peer-reviewed

    Fukushima A, Miura N, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06

  195. Cortical networks sensitive to the difference in motion and appearance of humanoid robot and human: an fMRI study. Peer-reviewed

    Miura N, Sugiura M, Takahashi M, Sassa Y, Moridaira T, Miyamoto A, Kuroki Y, Sato S, Horie K, Nakamura K, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06

  196. 認知リハビリテーション医学‐認知症に対する学習療法 (BRAIN and NERVE)

    関口敦, 川島隆太

    BRAIN and NERVE　59　(4)　357-365　2007/04

  197. 認知症の脳科学 (心療内科)

    立花良之, 川島隆太

    心療内科　11　(1)　19-24　2007/01/28

  198. 加齢に伴う脳灰白質体積の経時変化-健常被験者の脳MRI解析による8年間の縦断研究 第一報-

    瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

    日本医学放射線学会学術集会抄録集　66th　2007

    ISSN： 0048-0428

  199. Body Mass Indexと全脳及び局所灰白質量との相関-1428人の脳MR画像を用いたvoxel-based morphometryによる解析-

    瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 川島隆太

    日本医学放射線学会秋季臨床大会抄録集　43rd　2007

    ISSN： 0048-0428

  200. Nonlinear local neurovascular coupling in the cerebral cortex

    Jorge J. Riera, Juan C. Jimenez, Tohru Ozaki, Ryuta Kawashima, Xiaohong Wan

    NEUROSCIENCE RESEARCH　58　S129-S129　2007

    ISSN： 0168-0102

  201. Changes of the brain activity related to the differences in manner of articulation

    Shinya Uchida, Naoki Miura, Katsuki Nakamura, Kazunori Sato, Hiroshi Fukuda, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　58　S174-S174　2007

    ISSN： 0168-0102

  202. 健常高齢者における全脳及び局所灰白質量と認知力との相関 volumetry及びvoxel-based morphometryによる解析 (日本老年医学会雑誌)

    瀧靖之, 木之村重男, 佐藤和則, 内田信也, 後藤了以, 井上健太郎, 辻一郎, 荒井啓行, 川島隆太, 福田寛

    日本老年医学会雑誌　44　(1)　138-138　2007/01

  203. fMRI evidence for distinct neural mechanisms between the lexical and sentence processing: the case of the processing of passives.

    Yokoyama, S, K. Yoshimoto, T. Miyamoto, K. Horie, S. Sato, R. Kawashima

    NeuroImage: The 13th Annual Meeting of the Organizaion of Human Brain Mapping, June 10-14. Chicago.　36　(Supplement 1)　124 M-PM-　2007

  204. A longitudinal fMRI study of neural plasticity in the second language lexical processing.

    Satoru Yokoyama, Jungho Kim, Shinya Uchida, Hideyuki Okamoto, Chen Bai, Noriaki Yusa, Tadao Miyamoto, Kei Yoshimoto, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

    The 30th Meeting of the Japan Neuroscience Society, Yokohama, September 10-12　P2-h31　2007

  205. Cortical Mechanisms of Segmentation in Japanese Auditory Sentence Comprehension.

    Oshima, H, H. Jeong, M. Sugiura, T. Miyamoto, Y. Sassa, K. Wakusawa, K. Horie, S. Sato, R. Kawashima

    NeuroImage: The 13th Annual Meeting of the Organizaion of Human Brain Mapping, June 10-14. Chicago.　36　(Supplement 1)　104 M-PM-　2007

  206. 視覚単語認識中の意味アクセスへの二つの異なる神経回路網 Peer-reviewed

    Jeong, H, Sugiura M, Sassa Y, Miyamoto T, Horie K, Sato S, Kawashima, R

    神経化学　(46)　554　2007

  207. 新しい知識を獲得するときの興味に関する脳機能イメージング研究

    福島愛, 三浦直樹, 内田信也, 杉浦元亮, 堀江薫, 佐藤滋, 川島隆太

    第２８回日本神経科学大会　2006/07

  208. 言語関連領野の神経線維連絡：機能的MRIと拡散テンソル画像による検討

    内田信也, 三浦直樹, 渡邉丈夫, 木之村重男, 佐藤和則, 瀧靖之, 井上健太郎, 後藤了以, 岡田賢, 福島愛, 堀江薫, 佐藤滋, 中村克樹, 福田寛, 川島隆太

    第２８回日本神経科学大会　2006/07

  209. 計器監視課題における難易度の影響：fMRIによる研究

    三浦直樹, 高橋信, 渡邉丈夫, 内田信也, 佐藤滋, 堀江薫, 北村正晴, 若林利男, 中村克樹, 川島隆太

    第２８回日本神経科学大会　2006/07

  210. 情動形成とその異常の脳内機構 情動と心身相関のBlack Boxに迫る 身体感覚から情動形成に至る脳内過程とその異常 (心身医学)

    福土審, 濱口豊太, 鹿野理子, 渡辺諭史, 水野資子, 金澤素, 中谷久美, 相模泰宏, 庄司知隆, 遠藤由香, 青木正志, 糸山泰人, 川島隆太, 伊藤正敏, 谷内一彦, 本郷道夫

    心身医学　46　(6)　469-469　2006/06

  211. Universal Grammar and Instruction Effects on Second Language Grammar Formation: Evidence from fMRI Peer-reviewed

    Yusa N, Koizumi M, Kim J, Saki Y, Kimura N, Uchida S, Yokoyama S, Miura N, Horie K, Sato S, Kawashima R, Hagiwara H

    12th International Conference on Functional Mapping of the Human Brain　2006/06

  212. Impact of serotonin transporter gene on negative emotion and brain processing during fear conditioning: an event-related fMRI study Peer-reviewed

    Mizuno T, Sugiura M, Kano M, Miura N, Watanabe J, Hattori T, Sato S, Horie K, Aoki M, Itoyama Y, Kawashima R, Fukudo S

    12th International Conference on Functional Mapping of the Human Brain　2006/06

  213. Neural correlates of confidence judgment in retrieved answers: An fMRI study Peer-reviewed

    Yokoyama O, Miura N, Watanabe J, Takemoto A, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R, Nakamura K

    12th International Conference on Functional Mapping of the Human Brain　2006/06

  214. Cortical activation related to intellectual excitement Peer-reviewed

    Fukushima A, Miura N, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R

    12th International Conference on Functional Mapping of the Human Brain　2006/06

  215. Neural connectivity among regions related to language function: combined intersubject analysis by functional magnetic resonance imaging and diffusion tensor imaging tractography. Peer-reviewed

    Uchida S, Miura N, Watanabe J, Kinomura S, Sato K, Taki Y, Inoue K, Goto R, Okada K, Fukuda H, Kawashima R

    12th International Conference on Functional Mapping of the Human Brain　2006/06

  216. A relevant analysis of task difficulty and brain activity during meter inspection: an fMRI study Peer-reviewed

    Miura N, Takahashi M, Watanabe J, Uchida S, Sato S, Horie K, Kitamura M, Wakabayashi T, Nakamura K, Kawashima R

    12th International Conference on Functional Mapping of the Human Brain　2006/06

  217. Effect of motion smoothness on brain activation during dance observation: an fMRI study using a humanoid robot. Peer-reviewed

    Miura N, Sugiura M, Takahashi M, Sassa Y, Moridaira T, Miyamoto A, Kuroki Y, Sato S, Horie K, Nakamura K, Kawashima R

    12th International Conference on Functional Mapping of the Human Brain　2006/06

  218. 画像でみる高次脳機能 体性感覚性認知 指し示す(kinesthesia) PETによる局在(図説) (Clinical Neuroscience)

    井上健太郎, 川島隆太, 福田寛

    Clinical Neuroscience　24　374-375　2006/04

  219. ブレインインフォマティクスと加齢疾患 (生化学)

    川島隆太

    生化学　78　(3)　262-266　2006/03

  220. 各種の予防 認知刺激 (Progress in Medicine)

    川島隆太

    Progress in Medicine　26　(2)　397-400　2006/02

  221. 大脳,小脳の各解剖学的構造における局所灰白質量と年齢との相関-1460人の脳MRIを用いたROI解析-

    瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 小野修一, 川島隆太

    日本医学放射線学会秋季臨床大会抄録集　42nd　2006

    ISSN： 0048-0428

  222. Neural connectivity among brain areas related to language function

    Shinya Uchida, Naoki Miura, John Watanabe, Shigeo Kinomura, Kazunori Sato, Yasuyuki Taki, Kentaro Inoue, Ryoi Goto, Ai Fukushima, Kaoru Horie, Shigeru Sato, Katsuki Nakamura, Hiroshi Fukuda, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　55　S263-S263　2006

    ISSN： 0168-0102

  223. Correlation between semantic memory and regional gray matter volume of anterior aspect of right temporal lobe in normal elderly subjects. A voxel-based morphometry

    Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Shinya Uchida, Ryoi Goto, Kentaro Inoue, Ichiro Tsuji, Hiroyuki Arai, Ryuta Kawashima, Hiroshi Fukuda

    NEUROSCIENCE RESEARCH　55　S103-S103　2006

    ISSN： 0168-0102

  224. Distinct neural substrates for word recognition between L1 and L2

    Satoru Yokoyama, Jungho Kim, Shin-ya Uchida, Hideyuki Okamoto, Chen Bai, Tadao Miyamoto, Kei Yoshimoto, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　55　S131-S131　2006

    ISSN： 0168-0102

  225. Cortical activations correlated to cognitive trait during experience of risky situation: An fMRI study

    Atsushi Sekiguchi, Naho Ikuta, Motoald Sugiura, Hideyuki Okamoto, Shigeru Satou, Kaoru Horie, Ryuta Kawashima

    NEUROSCIENCE RESEARCH　55　S132-S132　2006

    ISSN： 0168-0102

  226. A model selection of GLM applied to fMRI data using AlC

    Jobu Watanabe, Fumikazu Miwakeichi, Andreas Galka, Ryuta Kawashima, Tohru Ozaki, Sunao Uchida

    NEUROSCIENCE RESEARCH　55　S260-S260　2006

    ISSN： 0168-0102

  227. Both global gray matter volume and regional gray matter volume negatively correlate with lifetime alcohol intake in non-alcohol-dependent Japanese men: a volumetric analysis and a voxel-based morphometry.

    Taki Yasuyuki, Kinomura Shigeo, Sato Kazunori, Goto Ryoi, Inoue Kentaro, Okada Ken, Ono Shuichi, Kawashima Ryuta, Fukuda Hiroshi

    Alcohol Clin Exp Res　30　(6)　1045-1050　2006

    DOI： 10.1111/j.1530-0277.2006.00118.x 　

  228. Cortical Mechanisms of Segmentation in Visual Sentence Comprehension of Japanese Kana

    Oshima, H, J. Hyeonjeong, M. Sugiura, T. Miyamoto, Y. Sassa, N. Ikuta, K. Horie, S. Sato, R. Kawashima

    NeuroImage: 12th Annual Meeting of the Organization for Human Brain Mapping. June 11-15, 2006, Florence, Italy.　31　(Supplement 1)　353 W-AW-　2006

  229. fMRI Evidence for Distinct Neural Substrates for Word Recognition in L1 and L2. 1

    Yokoyama,, S, J. Kim, S. Uchida, H. Okamoto, C. Bai, T. Miyamoto, K. Yoshimoto, K. Horie, S. Sato, R. Kawashima

    NeuroImage: 12th Annual Meeting of the Organization for Human Brain Mapping. June 11-15, 2006, Florence, Italy.　31　(Supplement 1)　313 W-AW-　2006

  230. 機能的MRIを用いた上顎前突者および下顎前突者における顎運動時の脳血流動態―正常咬合者との比較―

    吾妻佳奈, 佐藤亨至, 山本照子, 三浦直樹, 川島隆太

    日本矯正歯科学会大会プログラム・抄録集　65th　193　2006

  231. Influence of task difficulty during meter inspection: An fMRI study Peer-reviewed

    Miura Naoki, Takahashi Makoto, Watanabe Jobu, Uchida Shinya, Sato Shigeru, Horie Kaoru, Kitamura Masaharu, Wakabayashi Toshio, Nakamura Katsuki, Kawashima Ryuta

    NEUROSCIENCE RESEARCH　55　S263　2006

    ISSN： 0168-0102

  232. アルツハイマー病の予防と進展防止 脳機能訓練が有効であるとの立場から (Cognition and Dementia)

    川島隆太

    Cognition and Dementia　5　(1)　66-69　2006/01

  233. 脳科学の視点から新たな認知リハビリテーションの提案 (精神神経学雑誌)

    川島隆太

    精神神経学雑誌　107　(12)　1305-1309　2005/12

  234. Cognitive rehabilitation for Alzheimer disease : The Learning Therapy

    KAWASHIMA Ryuta

    Clinical neurology.　45　(11)　864-866　2005/11/01

    Publisher: 日本神経学会

    ISSN： 0009-918X

  235. 言語コミュニケーション・第2言語習得の言語認知科学

    SATO SHIGERU, JEONG HYEONJEONG, YOKOYAMA SATORU, IKUTA NAHO, SUGIURA MOTOAKI, KAWASHIMA RYUTA

    日本音響学会研究発表会講演論文集(CD-ROM)　2005　3-8-11　2005/09/20

    ISSN： 1880-7658

  236. 前頭葉の脳機能イメージング (特集 前頭前野機能の最前線--基礎から臨床まで)

    川島 隆太, 泰羅 雅登

    神経研究の進歩　49　(4)　583-589　2005/08

    Publisher: 医学書院

    ISSN： 0001-8724

  237. 前頭葉の脳機能イメージング (神経研究の進歩)

    川島隆太

    神経研究の進歩　49　(4)　583-589　2005/08

    DOI： 10.11477/mf.1431100075 　

  238. 日本語を学習した中国語母語話者における,日本語構文の理解に関わる脳活動

    岡本 英行, 白 晨, 横山 悟, 金 情浩, 内田 信也, 高橋 大厚, 中村 渉, 佐藤 滋, 堀江 薫, 川島 隆太

    認知神経科学　7　(2)　145-145　2005/07

    Publisher: 認知神経科学会

    ISSN： 1344-4298

  239. fMRI を用いたデジタル・アナログ計器監視時の脳活動比較

    三浦直樹, 渡邉丈夫, 長倉正人, 岩田一樹, 佐藤滋, 堀江薫, 高橋信, 北村正晴, 川島隆太

    第２８回日本神経科学大会　2005/07

  240. The brain activation of syntax comprehension in English-Japanese bilinguals: An fMRI study

    Okamoto H, Takahashi D, Sassa Y, Ikuta N, Jeong H, Iwata K, Watanabe J, Akitsuki Y, Miura N, Kawashima R

    Second International Workshop on Evolutionary Cognitive Sciences　2005/07

  241. Brain activation associated with the sentence processing: An fMRI study

    Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Riera J, Sato S, Horie K, Matsue Y, Kawashima R

    Second International Workshop on Evolutionary Cognitive Sciences　2005/07

  242. Effects of motion and the body part on activation of the left and right cortical networks for visual self-recognition: An event-related fMRI study. Peer-reviewed

    Sugiura M, Sassa Y, Jeong H, Miura N, Iwata K, Akitsuki Y, Horie K, Sato S, Kawashima R

    11th International Conference on Functional Mapping of the Human Brain　2005/06

  243. The role of the Broca's area and left parietal region during processing of a passive sentence in Japanese: An event-related fMRI study. Peer-reviewed

    Yokoyama S, Watanabe J, Iwata K, Sassa Y, Akitsuki Y, Miura N, Jeong H, Ikuta N, Okamoto H, Haji T, Usui N, Taira M, Nakamura W, Sato S, Horie K, Kawashima R

    11th International Conference on Functional Mapping of the Human Brain　2005/06

  244. Communicative speech production activates the frontal and anterior cingulate cortices: An fMRI study Peer-reviewed

    Sassa Y, Sugiura M, Jeong H, Miura N, Iwata K, Akitsuki Y, Yokoyama S, Watanabe J, Ikuta N, Okamoto H, Uchida S, Riera J, Horie K, Sato S, Kawashima R

    11th International Conference on Functional Mapping of the Human Brain　2005/06

  245. Brain Activation Associated with the Japanese Sentence Comprehension Peer-reviewed

    Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Watanabe Y, Sato S, Horie K, Matsue Y, Kawashima R

    11th International Conference on Functional Mapping of the Human Brain　2005/06

  246. Processing of Scrambled Ditransitive Constructions: An fMRI study Peer-reviewed

    Kim J, Koizumi M, Kimura N, Watanabe J, Yokoyama S, Ikuta N, Uchida S, Sassa Y, Akitsuki Y, Iwata K, Jeong H, Miura N, Yusa N, Sato S, Horie K, Kawashima R

    11th International Conference on Functional Mapping of the Human Brain　2005/06

  247. Parietal and Prefrontal Activation Associated with Algebraic Calculation: An fMRI study Peer-reviewed

    Watanabe J, Miura N, Iwata K, Sassa Y, Namikawa Y, Kawashima R

    11th International Conference on Functional Mapping of the Human Brain　2005/06

  248. Brain activation during inspection for digital and analog meters: An fMRI study Peer-reviewed

    Miura N, Watanabe J, Nagakura M, Iwata K, Sato S, Horie K, Takahashi M, Kitamura M, Kawashima R

    11th International Conference on Functional Mapping of the Human Brain　2005/06

  249. 前頭前野と音読・計算 (Clinical Neuroscience)

    川島隆太

    Clinical Neuroscience　23　(6)　623-625　2005/06

  250. 痴呆患者に対するリハビリテーション (内科)

    川島隆太

    内科　95　(5)　901-904　2005/05

  251. 成人の脳の可塑性と限界 (理学療法ジャーナル)

    川島隆太

    理学療法ジャーナル　39　(3)　209-213　2005/03

    DOI： 10.11477/mf.1551100046 　

  252. What is “normal aging brain for his/her age”?; The first report

    瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 伊藤浩, 井上健太郎, 岡田賢, 小野修一, 川島隆太, 川島隆太, 福田寛

    臨床放射線　50　(8)　2005

    ISSN： 0009-9252

  253. 「年齢相応の脳」とは?多施設での比較のために

    瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 福田寛, 川島隆太, 伊藤浩

    日本医学放射線学会秋季臨床大会抄録集　41st　2005

    ISSN： 0048-0428

  254. The neural network involved in the processing of give and receive expressions: An fMRI study

    Satoru Yokoyama, Noriaki Yusa, Jungho Kim, Hyeonjeong Jeong, Hideyuki Okamoto, Yuko Sassa, Naho Ikuta, Kei Yoshimoto, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

    NeuroImage　26　(S1)　49-　2005

  255. Cortical mechanisms of visual word processing: Comparison of Japanese Kana and Kanji processing during semantic and phonological tasks

    Hyeonjeong Jeong, Motoaki Sugiura, Yuko Sassa, Chen Bai, Kaoru Horie, Shigeru Sato, Ryuta Kawashima

    NeuroImage　26　(S1)　49-　2005

  256. Study on the Diagnosis Accuracy Improvement by Introducing the Experts Strategy

    猪谷達也, 三浦直樹, 高橋信, 川島隆太, 福田寛, 北村正晴

    知能システムシンポジウム資料　32nd　27-32　2005

  257. 在宅健常高齢者に対する認知トレーニング介入効果の検討

    内田 信也, 川島 隆太, 寳澤 篤, 大森 芳, 辻 一郎

    日本公衆衛生学会総会抄録集　63回　673-673　2004/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  258. 作業記憶課題における刺激提示速度変化に伴う脳活動量の検討

    内田信也, 岩田一樹, 渡辺丈夫, 佐々祐子, 三浦直樹, 木之村重男, 佐藤和則, 福田寛, 川島隆太

    第27回日本神経科学大会　2004/09

  259. L1、L2及びL3間の言語学的類似性と関連する神経機構

    鄭嫣, 岩田一樹, 渡辺丈夫, 佐々祐子, 生田奈穂, 秋月祐子, 三浦直樹, 岡本英行, 横山悟, Jorge Riera, 土師知己, 臼井信男, 泰羅雅登, 佐藤滋, 川島隆太

    第27回日本神経科学大会　2004/09

  260. fMRIによる文理解に関わる脳活動の研究

    生田奈穂, 秋月祐子, 佐々祐子, 渡辺丈夫, 岩田一樹, 三浦直樹, 岡本英行, 佐藤滋, 松江克彦, 川島隆太

    第27回日本神経科学大会　2004/09

  261. 代数的計算の脳活動: fMRI研究

    渡辺丈夫, 三浦直樹, 岩田一樹, 佐々祐子, 浪川幸彦, 川島隆太

    第27回日本神経科学大会　2004/09

  262. The brain activation of Japanese-English bilingual in sentence comprehension: An fMRI study

    Okamoto H, Takahashi D, Sassa Y, Sugiura M, Ikuta N, Iwata K, Watanabe J, Akitsuki Y, Miura N, Matsue K, Kawashima R

    The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004/09

  263. The role of linguistic typology in sentence comprehension by multilinguals: An fMRI study

    Jeong H, Iwata K, Watanabe J, Sassa Y, Akitsuki Y, Ikuta N, Okamoto H, Yokoyama S, Miura N, Riera J, Haji T, Usui N, Taira M, Sato S, Kawashima R

    The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004/09

  264. Comprehension of passive sentences in Japanese: An fMRI study.

    Yokoyama S, Watanabe J, Iwata K, Sassa Y, Miura N, Jeong H, Ikuta N, Akitsuki Y, Okamoto H, Haji T, Usui N, Taira M, Nakamura W, Sato S, Horie K, Kawashima R

    The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004/09

  265. 第一言語・第二言語の理解に関わる脳活動領域の特定(A shared network of cortical regions involved in a first and second language comprehension)

    横山 悟, 内田 信也, 岩田 一樹, 金 情浩, 岡本 英行, Hyeonjeong Jeong, 中村 渉, 堀江 薫, 佐藤 滋, 川島 隆太

    神経化学　43　(2-3)　572-572　2004/08

    Publisher: 日本神経化学会

    ISSN： 0037-3796

  266. 風景を見分ける PETによる局在 (Clinical Neuroscience)

    川島隆太

    Clinical Neuroscience　22　(8)　880-881　2004/08

  267. An fMRI study of brain activation during comprehension of passive sentences in Japanese and English

    YOKOYAMA Satoru, UCHIDA Shin-ya, IWATA Kazuki, KIM Jong-ho, JEONG Hyongjeong, OKAMOTO Hideyuki, WATANABE Jobu, SASSA Yuko, MIURA Naoki, AKITSUKI Yuko, IKUTA Naho, JORGE Riera, WAN Xiaohong, NAKAMURA Wataru, HORIE Kaoru, YOSHIMOTO Kei, SATO Shigeru, KAWASHIMA Ryuta

    Technical report of IEICE. Thought and language　104　(170)　25-30　2004/07/02

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    We carried out an fMRI study to investigate whether the same brain regions are involved in processing first and second languages. Twenty-eight right-handed native speakers of Japanese participated in this study. Subjects were instructed to read active and passive sentences in Japanese and English and to judge the plausibility of the sentence. As a result, we found that both similarites and differences between Japanese and English in terms of the regions involved in the processing of passive sentences. These results suggest that the processing of a second language exhibits both similarities and differences as contrasted with that of a first language.

  268. Changes in the activation pattern during the course of sentence comprehension Peer-reviewed

    Ikuta N, Iwata K, Sassa Y, Watanabe J, Akitsuki Y, Miura N, Okamoto H, Riera J, Sato S, Matsue Y, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  269. Comparison of Accuracy of Clinical Diagnosis by a Support System with Experienced Doctors using Functional Brain Images Peer-reviewed

    Takahashi M, Murooka S, Miura N, Matsumoto R, Kitamura M, Kawashima R, Kinomura S, Goto R, Inoue K, Fukuda H, Sato K

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  270. An fMRI study of scrambling effects on sentence comprehension Peer-reviewed

    Kim J, Koizumi M, Ikuta N, Fukumitsu Y, Akitsuki Y, Iwata K, Jeong H, Miura N, Okamoto H, Sassa Y, Watanabe J, Yokoyama S, Yusa N, Sato S, Horie K, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  271. Brain activation with the change of cognitive load during Paced Visual Serial Addition Task Peer-reviewed

    Uchida S, Iwata K, Watanabe J, Sassa Y, Miura N, Fukuda H, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  272. FMRI Evidence for the Neural Correlates of the Typological Differences among L1, L2, and L3 Peer-reviewed

    Jeong H, Iwata K, Watanabe J, Sassa Y, Akitsuki Y, Ikuta N, Miura N, Okamoto H, Yokoyama S, Riera J, Haji T, Usui N, Taira M, Horie K, Sato S, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  273. Parietal and Prefrontal Activation are involved in Algebraic Calculation: An fMRI study. Peer-reviewed

    Watanabe J, Miura N, Iwata K, Sassa Y, Namikawa Y, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  274. The role of the left frontal cortex during judgment of grammatical violation: An fMRI study Peer-reviewed

    Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Iwata K, Ikuta N, Miura N, Okamoto H, Sato S, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  275. An event-related fMRI study of how active and passive sentences are comprehended in Japanese Peer-reviewed

    Yokoyama S, Nakamura W, Watanabe J, Sassa Y, Iwata K, Akitsuki Y, Miura N, Jeong H, Ikuta N, Riera J, Okamoto H, Usui N, Taira M, Sato S, Horie K, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  276. An fMRI study of reading of ancient writings Peer-reviewed

    Miura N, Watanabe J, Iwata K, Sassa Y, Riera J, Tsuchiya H, Takahashi M, Kitamura M, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06

  277. Knowing the Brain, and Nursing the Brain : Recent Advancement of Brain Imaging Techniques

    KAWASHIMA Ryuta

    IEICE technical report. Neurocomputing　104　(99)　29-34　2004/05/21

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    The recent advancement of functional brain imaging techniques enable us to visualize functional organization of the human brain involved in higher cognitive functions. Therefore, education, sociology, linguistics, medicine, a variety of other disciplines and areas of brain science can collaborate and integrate. From the results of our brain imaging studies, we hypothesized that the fundamental learning of arithmetic and language might be activated bilateral prefrontal cortices, and that activation of the prefrontal cortex improve general prefrontal functions of those children. We, then, found clinical evidences to support our hypothesis by intervention studies.

  278. 痴呆からの脱出 学習療法の新展開 (遺伝: 生物の科学)

    川島隆太

    遺伝: 生物の科学　58　(3)　83-87　2004/05

  279. 味覚の神経機能イメージング (神経研究の進歩)

    福田寛, 内田信也, 木之村重男, 川島隆太

    神経研究の進歩　48　(2)　285-293　2004/04

    DOI： 10.11477/mf.1431100202 　

  280. 顔を見分ける PETによる局在 (Clinical Neuroscience)

    川島隆太

    Clinical Neuroscience　22　(4)　366-367　2004/04

  281. An Event-Related Functional Magnetic Resonance Imaging Study of Movement lmagery

    KAMIJO Ken-ichi, KAWASHIMA Ryuta, YAMAZAKI Toshimasa, KIYUNA Tomoharu, TAKAKI Yoko

    Transactions of the Japanese Society for Medical and Biological Engineering : BME　42　(1)　16-21　2004/03/10

    Publisher: Japanese Society for Medical and Biological Engineering

    ISSN： 1347-443X

    More details Close

    Through event-related functional magnetic resonance imaging (fMRI), brain activity was mapped in three normal subjects while they imagined grasping a softball with their own hand. During the right-hand-movement imagery task, the dorsolateral prefrontal cortices (BAs 9, 10 and 46), the supplementary motor area (SMA),the pre-motor cortex, the occipital cortices. the anterior cingulate gyrus and the cerebellum were significantly activated. Only in two subjects (YM and TK)did the present imagery task activate the right inferior parietal lobule (IPL) and the left superior temporal gyrus (STG),which are known to be involved in imagery requiring visuospatial information and in silent vocalization of the mimesis. respectively. This finding may exemplify that different imagery strategies activate different brain sites.

  282. SPECT 脳画像診断への自己組織化学習の適用

    猪谷達也, 松本怜, 三浦直樹, 高橋信, 川島隆太

    第 31 回計測自動制御学会知能システムシンポジウム　2004/03

  283. 受動文の理解における脳内での処理の負荷

    横山悟, 渡辺丈夫, 佐々祐子, 岩田一樹, 三浦直樹, 秋月祐子, 鄭嫣, 生田奈穂, ホルヘリエラ, 岡本英行, 土師知己, 臼井信男, 泰羅雅登, 中村渉, 佐藤滋, 堀江薫, 川島隆太

    言語処理学会第10回年次大会　2004/03

  284. まなざし 非言語コミュニケーションの脳機能イメージング研究 (脳と神経)

    川島隆太

    脳と神経　56　(2)　99-106　2004/02

  285. A functional MRI study of simple arithmetic--a comparison between children and adults.

    Kawashima Ryuta, Taira Masato, Okita Katsuo, Inoue Kentaro, Tajima Nobumoto, Yoshida Hajime, Sasaki Takeo, Sugiura Motoaki, Watanabe Job, Fukuda Hiroshi

    Brain Res Cogn Brain Res　18　(3)　227-233　2004

    DOI： 10.1016/j.cogbrainres.2003.10.009 　

  286. Analysis of brain activation during meter watching using functional MRI

    三浦直樹, 渡辺丈夫, 高橋信, 川島隆太, 北村正晴

    ヒューマンインタフェースシンポジウム論文集　2004 (CD-ROM)　3134　2004

    ISSN： 1345-0794

  287. SPECT画像による痴呆症の診断システムの研究 (2)医師との診断戦略の比較

    室岡澄子, 松本怜, 三浦直樹, 高橋信, 北村正晴, 川島隆太, 福田寛

    第37回日本エム・イー学会東北支部大会　2003/11

  288. SPECT画像による痴呆症の診断システムの研究 (1)機械学習による自動診断

    松本怜, 三浦直樹, 高橋信, 北村正晴, 川島隆太, 福田寛

    第37回日本エム・イー学会東北支部大会　2003/11

  289. 前頭前野？脳科学から教育・福祉へのメッセージ (医学のあゆみ)

    川島隆太

    医学のあゆみ　207　565-566　2003/11

  290. 脳を知り、脳を守り、脳を育む (電気学会誌)

    川島隆太

    電気学会誌　123　(10)　672-676　2003/10

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejjournal.123.672 　

    ISSN： 1340-5551

  291. 視線感知の脳内メカニズム 心の理論の解明を目指して (神経心理学)

    川島隆太

    神経心理学　19　(3)　156-161　2003/09

  292. 近赤外線分光法によるヘモグロビン濃度とfMRIによるBOLD信号との相関

    岩田一樹, 杉浦元亮, 渡邊丈夫, 秋月祐子, 佐々祐子, 渡部芳彦, 生田奈穂, 岡本英行, 三浦直樹, 前田泰弘, 松江克彦, 川島隆太

    第26回日本神経科学大会　2003/07

  293. 主語、目的語、動詞の処理に関わる脳領域

    生田奈穂, 杉浦元亮, 佐々祐子, 渡邊丈夫, 秋月祐子, 岩田一樹, 三浦直樹, 岡本英行, 渡部芳彦, 佐藤滋, 松江克彦, 川島隆太

    第26回日本神経科学大会　2003/07

  294. fMRIを用いた文法処理に伴う左前頭葉領域の脳賦活

    佐々祐子, 杉浦元亮, 渡邊丈夫, 秋月祐子, 岩田一樹, 生田奈穂, 三浦直樹, 岡本英行, 佐藤滋, 福田寛, 川島隆太

    第26回日本神経科学大会　2003/07

  295. Brain activation of different grammatical processing in Japanese sentences: An event related fMRI study Peer-reviewed

    Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Iwata K, Ikuta N, Miura N, Okamoto H, Sato S, Fukuda H, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06

  296. A method to estimate neuronal dynamic from BOLD signals Peer-reviewed

    Riera J, Watanabe J, Iwata K, Miura N, Aubert E, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06

  297. Brain Regions Involved in Appetite: An Event-related fMRI Study Peer-reviewed

    Watanabe Y, Sugiura M, Watanabe J, Akitsuki Y, Sassa S, Iwata K, Ikuta N, Miura N, Imaizumi O, Watanabe M, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06

  298. Brain areas involved in understanding of second language in Japanese: An fMRI study. Peer-reviewed

    Okamoto H, Takahashi T, Sugiura M, Sassa Y, Ikuta N, Iwata K, Watanabe J, Akitsuki Y, Miura N, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06

  299. Brain Activation Related to Spatial Divided Attention : An fMRI study Peer-reviewed

    Iwata K, Sugiura M, Watanabe J, Riera J, Akitsuki Y, Sassa Y, Watanabe Y, Miura N, Ikuta N, Okamoto H, Maeda Y, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06

  300. An fMRI study of reading aloud Peer-reviewed

    Miura N, Iwata K, Watanabe J, Sugiura M, Akitsuki Y, Sassa Y, Ikuta N, Okamoto H, Watanabe Y, Riera J, Maeda Y, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06

  301. 情動の機能解析 (最新医学)

    秋月祐子, 川島隆太

    最新医学　58　(3)　448-454　2003/03

  302. Encoding-related brain activity during deep processing of verbal materials : a PET study

    FUJII Toshikatsu, OKUDA Jiro, TSUKIURA Takashi, OHTAKE Hiroya, SUZUKI Maki, KAWASHIMA Ryuta, ITOH Masatoshi, FUKUDA Hiroshi, YAMADORI Atsushi

    44　(4)　429-438　2002/12/01

    ISSN： 0168-0102

  303. バーチャルリアリティーなどの視覚刺激に対する血管運動反応のカオス解析 (血管医学)

    山家智之, 南家俊介, 仁田新一, 田林光一, 川島隆太, 福田寛, 吉澤誠

    血管医学　3　(5)　529-535　2002/10

  304. 【知・情・意のバランス】 「知・情・意」の統合を育む 子どもの脳を育てる教育 (教育と医学)

    川島隆太

    教育と医学　50　(10)　882-887　2002/10

  305. 前頭前野機能発達・維持・増進システム開発研究 : (その1)高齢者の脳機能、知的機能、日常生活態度に与える読み書き計算学習の影響

    沖田克夫, 佐々木丈夫, 前山克次郎, 山崎律美, 川島隆太, 田島信元, 吉田甫, 泰羅雅登

    日本教育心理学会総会発表論文集　44　(44)　27-27　2002/08/09

    Publisher: 日本教育心理学会

    DOI： 10.20587/pamjaep.44.0_27 　

  306. Correlation between brain activity and personality scores reflects difference in spontaneous response to external stimuli

    M Sugiura, R Kawashima

    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY　45　(1-2)　38-38　2002/07

    ISSN： 0167-8760

  307. A principal component analysis on whole brain shape utilizing a spherical harmonics expansion Peer-reviewed

    Shida K, Hakoda N, Miura N, Kawashima R, Shimizu T, Fukuda H, Kawazoe Y

    8th International Conference on Functional Mapping of the Human Brain　2002/06

  308. Morphological analysis of MR brain images by spherical harmonics Peer-reviewed

    Hakoda N, Miura N, Shida K, Kawashima R, Fukuda H, Kawazoe Y, Shimizu T

    8th International Conference on Functional Mapping of the Human Brain　2002/06

  309. Automatic Brain Tissue Segmentation Method from MRI T1-weighted Data Peer-reviewed

    Miura N, Taneda A, Shida K, Kawashima R, Fukuda H, Kawazoe Y, Shimizu T

    8th International Conference on Functional Mapping of the Human Brain　2002/06

  310. 自己の顔認知のイメージング研究 (脳の科学)

    杉浦元亮, 川島隆太

    脳の科学　24　(4)　378-380　2002/04

  311. Acquisition of Diagnostic Knowledge from Functional Brain Image using Machine Learning

    ARAKAWA Kazuki, SAKAI Daisuke, TAKAHASHI Makoto, KITAMURA Masaharu, HUKUDA Hiroshi, KAWASHIMA Ryuta, AWATA Shuichi, TAKEDA Atsushi

    29　235-240　2002/03/28

  312. 3次元頭部MRI画像脳領域自動抽出法の提案とその性能評価

    三浦直樹, 種田晃人, 志田和人, 川島隆太, 川添良幸, 福田寛, 清水俊夫

    情報処理学会全国大会講演論文集　64th　(2)　2.243-2.244　2002/03/12

  313. 球面調和関数展開による脳表面形状特性解析

    箱田直子, 三浦直樹, 志田和人, 川島隆太, 川添良幸, 福田寛, 清水俊夫

    情報処理学会全国大会講演論文集　64th　(4)　4.313-4.314　2002/03/12

  314. 動作イメージ課題における脳内活動のfunctional MRIによる観察 (臨床脳波)

    上条憲一, 川島隆太, 山崎敏正

    臨床脳波　44　(3)　148-153　2002/03

  315. Changes in regional cerebral blood flow abnormalities in late-life depression following response to electroconvulsive therapy

    AWATA SHUICHI, KONNO MICHIKO, KAWASHIMA RYUTA, SUZUKI KAZUMASA, SATO TOSHIMITSU, MATSUOKA HIRO, FUKUDA HIROSHI, SATO MITSUMOTO

    Psychiatry and Clinical Neurosciences　56　(1)　31-40　2002/02/01

    ISSN： 1323-1316

  316. 脳血流SPECTカウントは脳灰白質密度を反映するか?

    木之村重男, 後藤了以, 井上健太郎, 中川学, 瀧靖之, 佐藤和則, 川島隆太, 福田寛

    核医学　39　(3)　2002

    ISSN： 0022-7854

  317. 臨床用MR画像による脳組織容積計測

    木之村重男, 小野修一, 後藤了以, 井上健太郎, 中川学, 杉浦元亮, 佐藤和則, 川島隆太, 福田寛

    日本医学放射線学会雑誌　62　(6)　2002

    ISSN： 0048-0428

  318. Time-Dependent Contribution of the Hippocampal Complex during Remembering the Past: A PET Study

    Tsukiura T., Fujii T., Okuda J., Ohtake H., Kawashima R., Itoh M., Fukuda H., Yamadori A.

    CYRIC annual report　2002　121-130　2002

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  319. 脳血流パターンの複雑性解析

    山家 智之, 久保 豊, 南家 俊介, 吉澤 誠, 川島 隆太, 杉浦 元亮, 田林 晄一, 田中 明, 竹田 宏, 仁田

    Therapeutic Research　23　(9)　1884-1887　2002

  320. Functional imaging studies of attention

    Ryuta Kawashima

    Clinical Neurology　41　(12)　1137-1139　2001/12/01

    ISSN： 0009-918X

  321. 報酬に対する脳活動変化の文脈依存性 event-related fMRI

    秋月 祐子, 杉浦 元亮, 渡辺 丈夫, 山下 圭一, 粟田 主一, 松岡 洋夫, 前田 泰弘, 松江 克彦, 福田 寛, 川島 隆太

    神経化学　40　(2-3)　402-402　2001/09

    Publisher: 日本神経化学会

    ISSN： 0037-3796

  322. functional MRIによる運動野領域の機能マッピング (脳の科学)

    川島隆太, 渡辺丈夫, 杉浦元亮, 佐藤優子, 前田泰弘, 松江克彦

    脳の科学　23　(9)　761-765　2001/09

  323. Normal aging and sexual dimorphism of Japanese brain

    R Goto, R Kawashima, A Zijdenbos, P Neelin, J Lerch, K Sato, S Ono, M Nakagawa, Y Taki, M Sugiura, J Watanabe, H Fukuda, AC Evans

    NEUROIMAGE　13　(6)　S794-S794　2001/06

    ISSN： 1053-8119

  324. Different functional roles of human frontal and parietal cortices in memory-guided saccade: An event-related fMRI study

    M Sugiura, R Kawashima, J Watanabe, Y Sato, Y Maeda, Y Matsue, K Sato, A Harada, H Fukuda

    NEUROIMAGE　13　(6)　S365-S365　2001/06

    ISSN： 1053-8119

  325. Functional MR imaging of cue-invariant shape perception

    K Nakamura, R Kawashima, A Hanazawa, Y Sato, M Sugiura, J Watanabe, K Sato, Y Maeda, Y Matsue, H Fukuda

    NEUROIMAGE　13　(6)　S917-S917　2001/06

    ISSN： 1053-8119

  326. fMRIからみた右半球症状 (臨床神経科学)

    杉浦元亮, 川島隆太, 福田寛

    臨床神経科学　19　(4)　434-436　2001/04

  327. 通信・放送機構 青葉脳画像リサーチセンターの紹介 : 統合的先端脳画像情報通信ネットワークに関する研究開発

    鈴木 一正, 志田 和人, 早川 友恵, 川添 良幸, 大槻 昌夫, 川島 隆太, 福田 寛

    画像電子学会誌　30　(2)　182-184　2001/03/25

    Publisher: 画像電子学会

    ISSN： 0285-9831

  328. 人の性格と脳活動の関係

    杉浦元亮, 川島隆太, 中川学, 岡田賢, 佐藤多智雄, 後藤了以, 佐藤和則, 小野修一, 福田寛

    加齢医学研究所雑誌　52　(1/2)　2001

    ISSN： 1340-3397

  329. パーキンソン病におけるInsular CortexとSupple mentary Motor Area(SMA)の脳血流低下

    菊池 昭夫, 武田 篤, 金原 禎子, 糸山 泰人, 中川 学, 川島 隆太, 福田 寛, 沖田 直, 高瀬 貞夫

    臨床神経学　40　(12)　1396-1396　2000/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  330. Contribution of the rostral part of the left temporal lobe to retrieving people's names: A functional MRI study

    Takashi Tsukiura, Takashi Tsukiura, Toshikatsu Fujii, Jiro Okuda, Jiro Okuda, Michio Tabuchi, Kengo Kurata, Kyoko Suzuki, Atsushi Umetsu, Ryuta Kawashima, Isao Yanagawa, Tatsuo Nagasaka, Atsushi Yamadori, Shoki Takahashi, Hiroshi Fukuda

    NeuroImage　11　2000/12/01

    ISSN： 1053-8119

  331. Functional MRIによる手指複雑運動(Luria's fist-edge-palm test)施行時の脳賦活部位の検討

    梅津篤司, 高橋昭喜, 日向野修一, 村田隆紀, 奥田次郎, 月浦崇, 藤井利勝, 山鳥重, 杉浦元亮, 井上健太郎, 川島隆太, 福田寛

    臨床放射線　45　(12)　1515-1523　2000/11

    Publisher: 金原出版(株)

    ISSN： 0009-9252

  332. Functional roles of the dorsal premoto cortex in sensory-triggered finger movement Peer-reviewed

    Sugiura M, Kawashima R, Takahashi T, Xiao R, Tsukiura T, Fukuda H, Iijima T

    The 30th Annual Meeting of Society for Neuroscience, New Orleans, USA　2000/11

  333. Functional imaging studies of human cognitive function

    KAWASHIMA Ryuta

    20　(3)　244-250　2000/09/30

    ISSN： 0285-9513

  334. Construction of a Large Scale 3D Image Database of Human Brain

    Kazuhito Shida, Yoshiyuki Kawazoe, Kazuya Kumekawa, Ryuta Kawashima, Masao Otsuki, Hiroshi Fukuda

    情報知識学会誌　10　(2)　2-11　2000/07

  335. Different response patterns of the human dorsal premotor cortex during sensory triggered movement with different sensory cues Peer-reviewed

    Sugiura M, Kawashima R, Takahashi T, Xiao R, Iijima T, Tsukiura T, Fukuda H

    6th Annual Conference of Organization for Human Brain Mapping, San Antonio, USA　2000/06

  336. Fast reaction to different sensory modalities activates common fields in the motor areas, but the anterior cingulate cortex is involved in the speed of reaction

    E Naito, S Kinomura, S Geyer, R Kawashima, PE Roland, K Zilles

    JOURNAL OF NEUROPHYSIOLOGY　83　(3)　1701-1709　2000/03

    ISSN： 0022-3077

  337. Human cerebellum plays an important role in memory-timed finger movement: An fMRI study

    Ryuta Kawashima, Jiro Okuda, Atsushi Umetsu, Motoaki Sugiura, Kentaro Inoue, Kyoko Suzuki, Michio Tabuchi, Takashi Tsukiura, Singh L. Narayan, Tatsuo Nagasaka, Isao Yanagawa, Toshikatsu Fujii, Shoki Takahashi, Hiroshi Fukuda, Atsushi Yamadori

    Journal of Neurophysiology　83　1079-1087　2000/02/23

    ISSN： 0022-3077

  338. 人の名前の長期記憶に関与する大脳領域

    杉浦元亮, 川島隆太, 渡辺丈夫, 佐藤和則, 福田寛, 佐藤優子, 前田泰弘, 松江克彦

    日本神経科学大会プログラム・抄録集　23rd　2000

    ISSN： 1347-8583

  339. Passive and active recognition of one's own face

    M Sugiura, R Kawashima, K Nakamura, E Okada, T Kato, A Nakamura, K Hatano, K Itoh, S Kojima, H Fukuda

    NEUROIMAGE　11　(1)　36-48　2000/01

    DOI： 10.1006/nimg.1999.0519 　

    ISSN： 1053-8119

  340. Recall of Embedded Words from a Story: a PET Study

    Ohtake H., Fujii T., Okuda J., Tsukiura T., Kawashima R., Itoh M., Fukuda H., Yamadori A.

    CYRIC annual report　2000　135-139　2000

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  341. Functional mapping of human brain in olfactory processing: a PET study.

    Qureshy A, Kawashima R, Imran M B, Sugiura M, Goto R, Okada K, Inoue K, Itoh M, Schormann T, Zilles K, Fukuda H

    J Neurophysiol　84　(3)　1656-1666　2000

  342. 顔認知に関するH215O‐PET activation study

    SUGIURA MOTOAKI, KAWASHIMA RYUTA, FUKUDA HIROSHI, NAKAMURA KATSUKI, SATO NOBUYA, KOJIMA SHOZO, KATO TAKASHI, NAKAMURA AKINORI, ITO KENGO

    核医学　36　(9)　1036　1999/12/20

    ISSN： 0022-7854

  343. パーキンソン病における脳血流SPECTの客観的検討

    菊池 昭夫, 武田 篤, 金原 禎子, 糸山 泰人, 中川 学, 川島 隆太, 福田 寛, 沖田 直, 高瀬 貞夫

    臨床神経学　39　(12)　1369-1369　1999/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  344. Activations of prefronto-parietal and temporal cortices during encoding and retrieval of visually presented words: A single-trial based fMRI Study

    Hiroshi Fukuda, Okuda Jiro, Okuda Jiro, Michio Tabuchi, Ryuta Kawashima, Atsushi Umetsu, Kyoko Suzuki, Takashi Tsukiura, Motoaki Sugiura, Kentaro Inoue, Isao Yanagawa, Tatsuo Nagasaka, Singh Laxmi Narayan, Singh Laxmi Narayan, Toshikatsu Fujii, Toshikatsu Fujii, Atsushi Yamadori, Shoki Takahashi

    NeuroImage　9　1999/12/01

    ISSN： 1053-8119

  345. Brain Activation Using Positron Emission Tomography

    36　(6)　536-536　1999/08/20

    ISSN： 0022-7854

  346. 運動と脳血流動態 (特集 リハビリテーシヨン医学の基礎--運動生理学)

    川島 隆太, 福田 寛

    総合リハビリテ-ション　27　(8)　713-717　1999/08

    Publisher: 医学書院

    ISSN： 0386-9822

  347. 顔の認知に関わる脳領野の個人差 intra‐subject PET activation study

    SUGIURA MOTOAKI, KAWASHIMA RYUTA, NAKAMURA KATSUKI, SATO NOBUYA, KATO RYUJI, NAKAMURA AKINORI, SCHORMANN T, ZILLES K, FUKUDA HIROSHI

    日本神経科学大会プログラム・抄録集　22nd　158　1999/07/06

    ISSN： 1347-8583

  348. Brain activation during generation and recall of word evaluated with functional MRI Peer-reviewed

    シン・ナラヤン, 奥田次郎, 鈴木匡子, 田渕実治郎, 月浦 崇, 梅津篤司, 梁川 功, 永坂竜男, 杉浦元亮, 井上健太郎, 川島隆太, 福田 寛, 高橋昭喜, 山鳥 重

    第22回日本神経科学大会，大阪　1999/07

  349. The neural basis of written language processing evaluated with functional magnetic resonance imaging Peer-reviewed

    田渕実治郎, 奥田次郎, 月浦 崇, 鈴木匡子, シン・ナラヤン, 藤井俊勝, 梅津篤司, 梁川 功, 永坂竜男, 川島隆太, 杉浦元亮, 井上健太郎, 高橋昭喜, 福田 寛, 山鳥 重

    第22回日本神経科学大会，大阪　1999/07

  350. A positron emission tomography study of self-paced finger movements at different frequencies.

    Kawashima R, Inoue K, Sugiura M, Okada K, Ogawa A, Fukuda H

    Neuroscience　92　(1)　107-112　1999

    DOI： 10.1016/S0306-4522(98)00744-1 　

  351. Three Dimensions in the State of Memory and Emotion Concerned with a Person: Factor Analysis Using Subject's Self Evaluation and PET

    Sugiura M., Kawashima R., Gotoh R., Okada K., Watanabe J., Satoh K., Yamaguchi K., Itoh M., Schormann T., Fukuda H.

    CYRIC annual report　1999　177-181　1999

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  352. A comparison of Tc-99m HMPAO brain SPECT images of young and aged normal individuals

    GOTO Ryoi, KAWASHIMA Ryuta, ITO Hiroshi, KOYAMA Masamichi, SATO Kazunori, ONO Shuichi, YOSHIOKA Seiro, FUKUDA Hiroshi

    Ann Nucl Med　12　(6)　333-339　1998/12/01

    ISSN： 0914-7187

  353. 無痙攣電撃療法によるうつ病脳SPECT所見の変化

    川島 隆太, 福田 寛, 粟田 主一, 金野 倫子, 佐藤 光源

    核医学　35　(9)　956-956　1998/11

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  354. Functional Anatomy of Auditory Attention - PET studies -

    KAWASHIMA Ryuta, GOTO Ryoi, FUKUDA Hiroshi

    1998　(2)　405-406　1998/09/01

    ISSN： 1340-3168

  355. 鬱病患者の無痙攣電撃療法に伴う脳血流変化 99mTc-HMPAO-SPECT study

    杉浦 元亮, 川島 隆太, 木之村 重男, 福田 寛, 金野 倫子, 粟田 主一, 佐藤 光源

    核医学　35　(7)　543-543　1998/08

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  356. Regional cerebral blood flow abnormalities in late-life depression : Relation to refractoriness and chronification

    AWATA SHUICHI, ITO HIROSHI, KONNO MICHIKO, ONO SHUICHI, KAWASHIMA RYUTA, FUKUDA HIROSHI, SATO MITSUMOTO

    Psychiatry Clin. Neurosci.　52　(1)　97-105　1998/02/01

    ISSN： 1323-1316

  357. PETによるヒトの手の運動機能マップ (特集 手の運動の制御と学習)

    川島 隆太, 井上 健太郎, 松村 道一

    神経研究の進歩　42　(1)　139-145　1998/02

    Publisher: 医学書院

    ISSN： 0001-8724

  358. Construction of a Large Scale Database of Brain Images

    Shida Kazuhito, Kawazoe Yoshiyuki, Kumekawa Kazuya, Kawashima Ryuta, Otsuki Masao, Fukuda Hiroshi

    Proceedings of the Society Conference of IEICE　19-19　1998

    Publisher: The Institute of Electronics, Information and Communication Engineers

  359. 認知神経科学と非侵襲性技法の進歩 (特集 ニュ-ロサイエンス最前線--脳と心のメカニズムを探る)

    川島 隆太, 福田 寛

    数理科学　36　(1)　55-59　1998/01

    Publisher: サイエンス社

    ISSN： 0386-2240

  360. Olfactory Stimulus Processing by Human Brain-A Functional Study

    Qureshy A., Kawashima R., Imran M. B., Sugiura M., Goto R., Okada K., Inoue K., Itoh M., Fukuda H.

    CYRIC annual report　1998　155-160　1998

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  361. 「自己の顔」の内部表象: PET activation study Peer-reviewed

    杉浦元亮, 川島隆太, 中村克樹, 岡田賢, 加藤隆司, 中村昭範, 旗野健太郎, 伊藤健吾, 小嶋I三, 福田寛

    第21回神経科学第41回神経化学合同大会（1998年9月, 東京). プログラム／抄録集 p. 218.　1998

  362. Neural processes of speaker and emotion recognition from spoken words.

    IMAIZUMI SATOSHI, MORI KOICHI, KIRITANI SHIGERU, KAWASHIMA RYUTA, SUGIURA MOTOAKI, ITO KENGO, KATO TAKASHI, KOJIMA SHOZO, NAKAMURA KATSUKI

    日本音響学会研究発表会講演論文集　1997　(2)　391-392　1997/09

    ISSN： 1340-3168

  363. 脳科学シリ-ズ-14-ポジトロンCTによる記憶のメカニズムの解明

    川島 隆太, 福田 寛

    臨床科学　33　(8)　1008-1012　1997/08

    Publisher: エ-スア-ト

    ISSN： 0385-0323

  364. A method for the quantification of benzodiazepine receptors by using ^<123>I-iomazenil and SPECT with one scan and one blood sampling

    ITO Hiroshi, KAWASHIMA Ryuta, KOYAMA Masamichi, GOTO Ryoui, SATO Kazunori, ONO Shuichi, FUKUDA Hiroshi

    11　(2)　101-108　1997/05

    ISSN： 0914-7187

  365. Cerebral perfusion changes in traumatic diffuse brain injury; IMP SPECT studies

    ITO Hiroshi, ISHII Kiyoshi, ONUMA Takehide, KAWASHIMA Ryuta, FUKUDA Hiroshi

    Ann Nucl Med　11　(2)　167-172　1997/05

    ISSN： 0914-7187

  366. Functions of Parahippocampal Regions and Frontal Lobes in Alternative Judgment of Novelty and Familiarity for Auditorily Presented Words

    Motooka N., Okuda J., Fujii T., Yamadori A., Tsukiura T., Kawashima R., Fukatsu R., Suzuki K., Ito M., Fukuda H.

    CYRIC annual report　1997　132-137　1997

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  367. Development of a New Statistical Evaluation Method for Brain SPECT Images

    KAWASHIMA Ryuta, SATO Kazunori, ITO Hiroshi, KOYAMA Masamichi, GOTO Ryoui, YOSHIOKA Seiro, ONO Syuichi, SATO Sachio, FUKUDA Hiroshi

    33　(12)　1359-1362　1996/12/20

    ISSN： 0022-7854

  368. 運動を遂行させる脳への血液循環 (特集 運動中の血液需給システム)

    川島 隆太, 岡田 賢, 福田 寛

    体育の科学　46　(10)　801-805　1996/10

    Publisher: 杏林書院

    ISSN： 0039-8985

  369. ポジトロンCTによる随意運動の機能解剖 (特集 巧みな動作の脳機構)

    川島 隆太, 福田 寛

    体育の科学　46　(6)　472-476　1996/06

    Publisher: 杏林書院

    ISSN： 0039-8985

  370. 集中的医用画像情報処理システム

    福田 寛, 川島 隆太, 佐藤 和則

    画像電子学会誌　25　(1)　89-91　1996/02/25

    Publisher: 画像電子学会

    ISSN： 0285-9831

  371. Normal CBF Values by the ARG Method Using IMP SPECT:Comparison with a Conventional Microsphere Model Method

    ITO Hiroshi, ISHII Kiyoshi, KINOSHITA Toshifumi, KOYAMA Masamichi, KAWASHIMA Ryuta, ONO Syuichi, FUKUDA Hiroshi

    33　(2)　175-178　1996/02/20

    ISSN： 0022-7854

  372. Normal Cerebral Perfusion of ^<99m>Tc-ECD Brain SPECT : Evaluation by an Anatomical Standardization Technique

    KAWASHIMA Ryuta, KOYAMA Masamichi, ITO Hiroshi, YOSHIOKA Seiro, SATO Kazunori, ONO Shuichi, GOTO Ryoi, ONO Tachio, FUKUDA Hiroshi

    33　(1)　69-72　1996/01/20

    ISSN： 0022-7854

  373. A PET Study of Memory for Future Plan

    Okuda J., Fujii T., Yamadori A., Kawashima R., Fukatsu R., Suzuki K., Tsukiura T., Motooka N., Ito M., Fukuda H.

    CYRIC annual report　1996　172-175　1996

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  374. Error analysis of autoradiography method for measurement of cerebral blood flow by ^<123>I-IMP brain SPECT: A comparison study with table look-up method and microsphere model method

    ITO Hiroshi, ISHII Kiyoshi, ATSUMI Hiroto, INUKAI Yoshimasa, ABE Shigeto, SATO Masami, KINOSHITA Toshifumi, KAWASHIMA Ryuta, ONO Shuichi, FUKUDA Hiroshi

    Ann Nucl Med　9　(4)　185-190　1995/11/01

    ISSN： 0914-7187

  375. PETによる脳機能マッピング (脳機能イメ-ジング<特集>)

    川島 隆太, 福田 寛

    医学のあゆみ　175　(3)　p185-188　1995/10/21

    Publisher: 医歯薬出版

    ISSN： 0039-2359

  376. Normal Cerebral Perfusion of ^<99m>Tc-HMPAO Brain SPECT : Evaluation by an Anatomical Standardization Technique

    KOYAMA Masamichi, KAWASHIMA Ryuta, ITO Hiroshi, ONO Shuichi, SATO Kazunori, GOTO Ryoui, AKAIZAWA Takashi, YOSHlOKA Seiro, SATO Tachio, FUKUDA Hiroshi

    KAKU IGAKU (Jpn J Nucl Med)　32　(9)　969-977　1995/09/20

    ISSN： 0022-7854

  377. 脳

    川島 隆太, 福田 寛

    核医学　32　(8)　731-731　1995/08/20

    ISSN： 0022-7854

  378. A New 3-Dimensional Head Fixation Device for Brain Imaging

    GOTO Ryoi, KAWASHIMA Ryuta, YOSHlOKA Seiro, ONO Shuichi, ITO Hiroshi, SATO Kazunori, AKAIZAWA Takashi, KOYAMA Masamichi, FUKUDA Hiroshi

    32　(7)　689-694　1995/07/20

    ISSN： 0022-7854

  379. FUNCTIONAL-ANATOMY OF TASTE PERCEPTION IN THE HUMAN BRAIN STUDIED WITH POSITRON EMISSION TOMOGRAPHY

    S KINOMURA, R KAWASHIMA, K YAMADA, S ONO, M ITOH, S YOSHIOKA, T YAMAGUCHI, H MATSUI, H MIYAZAWA, H ITOH, R GOTO, T FUJIWARA, K SATOH, H FUKUDA

    BRAIN RESEARCH　659　(1-2)　263-266　1994/10

    ISSN： 0006-8993

  380. Functional Organization of the Human Primary Motor Area: An Update on Current Concepts

    Ryuta Kawashima, Hiroshi Fukuda

    Reviews in the Neurosciences　5　(4)　347-354　1994

    DOI： 10.1515/REVNEURO.1994.5.4.347 　

    ISSN： 2191-0200 0334-1763

  381. Handedness and Motor Function - CBF Study -

    Kawashima R., Yamada K., Kinomura S., Yamaguchi T., Matsui H., Fukuda H.

    CYRIC annual report　1990　215-217　1990

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

Show all ︎Show first 5

Books and Other Publications 5

  1. 機能的脳イメージング法．言語コミュニケーション障害の新しい視点と介入理論（

    佐々祐子, 生田奈穂, 鄭嫣婷, 川島隆太

    医学書院　2005/09/15

  2. 脳の形態と機能

    福田寛 ed, 岩田一樹, ホルヘ・リエラ, 川島隆太

    新興医学出版社　2005/06/28

  3. 対照言語学の新展開

    佐藤滋, 堀江薫, 中村渉 ed, 佐々祐子, 佐藤滋, 川島隆太

    ひつじ書房　2004/08/09

  4. 医食同源「痴呆・ボケ」

    川島隆太

    実業之日本社　2004/06/09

  5. 脳の高次機能

    丹治順, 吉澤修治, 川島隆太

    朝倉書店　2001/04/06

Presentations 267

  1. 脳の働きと朝ごはん

    川島隆太

    日本食育学会　2007/12/08

  2. 脳を知り、脳を鍛える

    川島隆太

    第46回日本臨床細胞学会秋期大会　2007/11/30

  3. 外国語学習者の言語能力評価における脳機能データの応用

    横山悟, 吉本啓, 川島隆太

    思考と言語研究会　2007/11/16

  4. 認知症改善・予防とケア

    川島隆太

    第15回日本介護福祉学会大会　2007/10/06

  5. 脳を知り、脳を鍛える

    川島隆太

    日本歯科技工学会第29回学術大会　2007/09/22

  6. Brain activities related to inferring familiar and unfamiliar persons’ decision-makings: An fMRI study

    Tachibana Y, Sugiura M, Sassa Y, Jeong H, Wakusawa K, Fukushima A, Kawashima R

    第30回日本神経科学会大会　2007/09/10

  7. 自己肯定に関する脳機能イメージング研究

    福島愛, 杉浦元亮, 三浦直樹, 内田信也, 関口敦, 堀江薫, 佐藤滋, 川島隆太

    第30回日本神経科学会大会　2007/09/10

  8. 内省未来志向のコーピングスタイルは右側頭領域の活動が関与している

    Sekiguchi A, Sugiura M, Yokoyama S, Kanbara T, Ikuta N, Sato S, Horie K, Kawashima R

    第30回日本神経科学会大会　2007/09/10

  9. A longitudinal fMRI study of neural plasticity in the second language lexical processing

    Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

    第30回日本神経科学会大会　2007/09/10

  10. Reanalysis in Japanese sentence comprehension: An fMRI study

    Ikuta N, Yokoyama S, Jeong H, Sugiura M, Horie K, Sato S, Kawashima R

    第30回日本神経科学会大会　2007/09/10

  11. Prevention of senile dementia by brain training: a message from neuroimaging research International-presentation

    Kawashima R

    The third World Ageing & Generations Congress　2007/09/06

  12. 日本語の脳内における統語処理と語彙意味処理のfMRI研究

    神原利宗, 横山悟, 生田奈穂, 鄭嫣婷, 高橋慶, 関口敦, 宮本正夫, 高橋大厚, 小泉政利, 吉本啓, 堀江薫, 佐藤滋, 川島隆太

    日本認知科学会第24回大　2007/09/03

  13. 専門職としての脳の鍛え方―創造的思考を育てるために

    川島隆太

    第38回日本看護学会　2007/08/09

  14. Working memory system as a sentence processor in the human brain International-presentation

    Yokoyama S, Takahashi K, Kambara T, Miyamoto T, Yoshimoto K, Kawashima R

    An International Workshop on Mental Architecture for Processing and Learning of Language　2007/07/14

  15. 脳を知り，脳を鍛える

    川島隆太

    第20回日本顎関節学会総会　2007/07/13

  16. 自己と他者を分ける脳活動と自我同一性との関係

    立花良之, 杉浦元亮, 佐々裕子, 横山悟, Hyeonjeong Jeong, 涌澤圭介, 福島愛, 川島隆太

    第29回日本生物学的精神医学会大会　2007/07/11

  17. Neural plasticity for second language learning in the brain: A longitudinal fMRI study

    Yokoyama S, Kim J, Uchida S, Bai C, Okamoto H, Yusa N, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

    The Japanese Society for Language Sciences' Ninth Annual International Conference　2007/07/07

  18. fMRI evidence for distinct neural mechanisms between the lexical and sentence processing: the case of the processing of passives International-presentation

    Yokoyama S, Yoshimoto K, Miyamoto T, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/28

  19. Cortical networks sensitive to the difference in motion and appearance of humanoid robot and human: an fMRI study International-presentation

    Miura N, Sugiura M, Takahashi M, Sassa Y, Moridaira T, Miyamoto A, Kuroki Y, Sato S, Horie K, Nakamura K, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  20. Syntactic and Lexical-semantic Processing during Sentence Comprehension in Head-final Language International-presentation

    Kambara T, Yokoyama S, Ikuta N, Jeong H, Takahashi K, Sekiguchi A, Miyamoto T, Takahashi D, Yoshimoto K, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  21. Brain activities, which related to ego identity and social distinction between self and others International-presentation

    Tachibana Y, Sugiura M, Sassa Y, Jeong H, Wakusawa K, Fukushima A, Sato S, Horie K, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  22. Domain-specific person-representations in posterior cortices: an fMRI study on famous-name recognition International-presentation

    Sugiura M, Sassa Y, Wakusawa K, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  23. Brain activation associated with reanalysis in sentence comprehension: An fMRI study International-presentation

    Ikuta N, Yokoyama S, Jeong H, Sugiura M, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  24. Cortical mechanism of ideal self – an fMRI study International-presentation

    Fukushima A, Miura N, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  25. The neural mechanisms of the second language comprehension International-presentation

    Oshima R, Ikuta N, Sugiura M, Yokoyama S, Jeong H, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  26. The difference of the brain activation in the left prefrontal regions in language proficiency International-presentation

    Oshima R, Ikuta N, Sugiura M, Yokoyama S, Jeong H, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  27. Activity in the right temporal pole is associated with the self-prospective direction in stress coping patterns International-presentation

    Sekiguchi A, Sugiura M, Yokoyama S, Kanbara T, Ikuta N, Sato S, Horie K, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  28. Development of L2 lexical processing: A longitudinal fMRI study International-presentation

    Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

    13th Annual Meeting of the Organization for Human Brain Mapping　2007/06/10

  29. 脳科学からみた、早寝・早起き・朝ごはんの重要性

    川島隆太

    平成19年度第一回食育推進交流シンポジウム　2007/06/05

  30. 脳を知り、脳を鍛える

    川島隆太

    第48回日本心身医学会　2007/05/24

  31. 食と脳科学

    川島隆太

    第50回日本糖尿病学会年次学術集会　2007/05/24

  32. Thematic difficulty causes processing cost for sentence comprehension International-presentation

    Yokoyama S, Koizumi M, Kim J, Yusa N, Yoshimoto K, Kawashima R

    2nd European cognitive science conference　2007/05/23

  33. Linearizability of neuro-vascular coupling resulting from low-frequency intermediate-duration stimuli International-presentation

    Rasmussen T, Lauritzen M, Kawashima R

    The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function and The 8th International Conference on Quantification of Brain Function with PET　2007/05/20

  34. 脳を知り、脳を鍛え、認知症を予防する

    川島隆太

    第10回国際福祉健康産業展覧会　2007/05/18

  35. 脳科学が教える脳の鍛え方

    川島隆太

    第46回日本生体医工学会大会　2007/04/25

  36. Brain activation during second language processing: A cross-linguistic approach International-presentation

    Jeong H, Sugiura M, Sato S, Kawashima R

    American Association of Applied Linguistics, Costa Mesa　2007/04/22

  37. 脳科学から新産業を創製する

    川島隆太

    第63回日本放射線技術学会　2007/04/13

  38. 有名人の性格と知識はそれぞれ左側頭頭頂接合部と中側頭回で表象されている

    杉浦元亮, 佐々祐子, 涌澤圭介, 堀江薫, 佐藤滋, 川島隆太

    第9回日本ヒト脳機能マッピング学会大会　2007/03/16

  39. 脳を知り、脳を鍛える

    川島隆太

    第41回日本成人病学会　2007/01/13

  40. fMRIによるかき混ぜ文の処理に関する研究？刺激呈示モダリティに依存しない脳活動の特定

    生田奈穂, 金情浩, 小泉政利, 佐藤滋, 堀江薫, 川島隆太

    日本言語学会第133回大会　2006/11/18

  41. 脳を知り、脳を育む

    川島隆太

    第9回日本腎不全看護学会　2006/11/11

  42. 脳を鍛える

    川島隆太

    第17回全国介護施設老人保健施設大会　2006/11/08

  43. 脳の健康

    川島隆太

    日本健康科学学会第22回学術大会　2006/10/27

  44. Context dependency of self concept during face recognition: fMRI evidence International-presentation

    Sugiura M, Sassa Y, Joeng H, Wakusawa K, Horie K, Sato S, Kawashima R

    36th Annual Meeting of Society for Neuroscience　2006/10/14

  45. Concurrent EEG correlates of event-related and spontaneous fMRI: implications for neural basis of functional imaging International-presentation

    Wan X, Riera J, Kawashima R

    28th International Congress of Clinical Neurophysiology,　2006/09/10

  46. Neural mechanisms for visual word recognition in the second language International-presentation

    Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

    CBL Seminar　2006/08/08

  47. 空間フィルターを用いたEEG/MEGソースにおける空間分解能の最適化

    Wan Xiaohong, 関口敦, 横山悟, Riera Jorge, 川島隆太

    第29回日本神経科学大会　2006/07/19

  48. 計器監視課題における難易度の影響：fMRIによる研究

    三浦直樹, 高橋信, 渡邉丈夫, 内田信也, 佐藤滋, 堀江薫, 北村正晴, 若林利男, 中村克樹, 川島隆太

    第29回日本神経科学大会　2006/07/19

  49. 第一言語と第二言語の単語理解は異なる脳内基盤で処理される

    横山悟, キムジュンホ, 内田信也, 岡本英行, バイチェン, 宮本正夫, 吉本啓, 堀江薫, 佐藤滋, 川島隆太

    第29回日本神経科学大会　2006/07/19

  50. 言語関連領野の神経線維連絡：機能的MRIと拡散テンソル画像による検討

    内田信也, 三浦直樹, 渡邉丈夫, 木之村重男, 佐藤和則, 瀧靖之, 井上健太郎, 後藤了以, 岡田賢, 福島愛, 堀江薫, 佐藤滋, 中村克樹, 福田寛, 川島隆太

    第29回日本神経科学大会　2006/07/19

  51. 外国語語彙の学習と想起の記憶転移に関わる神経機構

    Hyeonjeong Jeong, 杉浦元亮, 佐々裕子, 涌澤圭介, 堀江薫, 佐藤滋, 川島隆太

    第29回日本神経科学大会　2006/07/19

  52. 危険／安全な状況下における脳活動の個人差解析：機能的MRIによる研究

    関口敦, 生田奈穂, 杉浦元亮, 岡本英行, 佐藤滋, 堀江薫, 川島隆太

    第29回日本神経科学大会　2006/07/19

  53. 新しい知識を獲得するときの興味に関する脳機能イメージング研究

    福島愛, 三浦直樹, 内田信也, 杉浦元亮, 堀江薫, 佐藤滋, 川島隆太

    第29回日本神経科学大会　2006/07/19

  54. 危険認知の大脳機構

    杉浦元亮, 関口敦, 涌澤圭介, 佐々祐子, ジョンヒョンジョン, 堀江薫, 佐藤滋, 川島隆太

    第29回日本神経科学大会　2006/07/19

  55. 皮肉比喩理解のｆMRIによる検討

    涌澤圭介, 杉浦元亮, 佐々祐子, ジョンヒョンジョン, 堀江薫, 佐藤滋, 横山浩之, 飯沼一宇, 川島隆太

    第29回日本神経科学大会　2006/07/19

  56. 推論と言語算出に基づく言語コミュニケーションに関与する脳内ネットワーク

    佐々祐子, 杉浦元亮, ジョンヒョンジョン, 涌澤圭介, 堀江薫, 佐藤滋, 川島隆太

    第29回日本神経科学大会　2006/07/19

  57. 健常高齢者における，意味記憶と右側頭葉の局所灰白質量との相関？voxel-based morphometryによる解析？

    瀧靖之, 木之村重男, 佐藤和則, 内田信也, 後藤了以, 井上健太郎, 辻一郎, 荒井啓行, 粟田主一, 川島隆太, 福田寛

    第29回日本神経科学大会　2006/07/19

  58. Cortical mechanism of Pictogram processing: an fMRI study International-presentation

    Akitsuki Y, Sugiura M, Ikuta N, Matsuoka H, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  59. The intrinsic oscillations of human visual cortex: the sources of alpha rhythm International-presentation

    Wan X, Sekiguchi A, Yokoyama S, Fukushima A, Riera J, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  60. Brain activation associated with the processing of the scrambling: An fMRI study International-presentation

    Ikuta N, Kim J, Koizumi M, Saito H, Sekiguchi A, Okamoto H, Suzuki D, Jeong H, Sassa Y, Yokoyama S, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  61. Cross-generational changes of hemisphelic shape of Japanese brains: An MRI analysis International-presentation

    Sato K, Kinomura S, Taki Y, Goto1 R, Uchida S, Inoue K, Okada K, Furumoto M, Kawashima R, Fukuda H

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  62. Approaching neuronal computation and functional neuroimaging International-presentation

    Riera J, Jimenez JC, Ozaki T, Wan X, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping.　2006/06/11

  63. An fMRI study of oral translation between Japanese and English International-presentation

    Tatsumi K, Ikuta N, Deguchi H, Nagao H, Okamoto H, Sekiguchi A, Sugiura M, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  64. Differential activation patterns between word and sentence translation tasks between Japanese and English: an functional MRI study International-presentation

    Tatsumi K, Ikuta N, Deguchi H, Nagao H, Okamoto H, Sekiguchi A, Sugiura M, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  65. Changes of brain activation related to Japanese syntax comprehension in Chinese and Korean natives during learning of Japanese International-presentation

    Okamoto H, Bai C, Yokoyama S, Kim J, Uchida S, Jeong H, Sassa Y, Ikuta N, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  66. Effect of motion smoothness on brain activation during dance observation: an fMRI study using a humanoid robot International-presentation

    Miura N, Sugiura M, Takahashi M, Sassa Y, Moridaira T, Miyamoto A, Kuroki Y, Sato S, Horie K, Nakamura K, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  67. A relevant analysis of task difficulty and brain activity during meter inspection: an fMRI study International-presentation

    Miura N, Takahashi M, Watanabe J, Uchida S, Sato S, Horie K, Kitamura M, Wakabayashi T, Nakamura K, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  68. Cooking activates bilateral prefrontal cortex, and can be applied as an intervention method to improve prefrontal function of elders. –Bridges between neuroimaging and social science- International-presentation

    Iwata K, Yamashita M, Hotehama M, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  69. Mapping cortical networks involved in reasoning using fMRI and DTI tractography International-presentation

    Kawashima R, Masunaga H, Horn JL, Sassa Y, Wan X, Sekiguchi A, Uchida S, Sato S, Horie K

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  70. The Second Language is processed independently of the first language International-presentation

    Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Yusa N, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  71. fMRI evidence for distinct neural substrates for word recognition in L1 and L2 International-presentation

    Yokoyama S, Kim J, Uchida S, Okamoto H, Bai C, Miyamoto T, Yoshimoto K, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  72. Neural connectivity among regions related to language function: combined intersubject analysis by functional magnetic resonance imaging and diffusion tensor imaging tractography International-presentation

    Uchida S, Miura N, Watanabe J, Kinomura S, Sato K, Taki Y, Inoue K, Goto R, Okada K, Fukuda H, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  73. Learning-induced neural deactivation related to two different modes of second language vocabulary acquisition International-presentation

    Jeong H, Sugiura M, Sassa Y, Wakusawa K, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  74. Risk perception: Mechanisms for Processing of Risk-Signals Related to Object and Action-Direction International-presentation

    Sugiura M, Sekiguchi A, Wakusawa K, Sassa Y, Jeong H, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  75. Cortical mechanism of feeling inference and speech content production in communication: an fMRI study International-presentation

    Sassa Y, Sugiura M, Jeong H, Wakusawa K, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  76. Neural substrates[RK1] underlying individual differences in response to a risky situation: An fMRI study International-presentation

    Sekiguchi A, Ikuta N, Sugiura M, Okamoto H, Sato S, Horie K, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping.　2006/06/11

  77. Explaining: An fMRI Analysis of Two Hypothesized Mechanisms International-presentation

    Suzuki W, Jeong H, Sugiura M, Fukushima A, Sassa Y, Wakusawa K, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  78. Cortical Mechanisms of Segmentation in Visual Sentence Comprehension of Japanese Kana International-presentation

    Oshima H, Jeong H, Sugiura M, Miyamoto T, Sasa Y, Ikuta N, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  79. Cortical mechanisms of irony and metaphor comprehension: an fMRI study International-presentation

    Wakusawa K, Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, Yokoyama S, Tuchiya S, Iinuma I, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  80. Cortical activation related to intellectual excitement International-presentation

    Fukushima A, Miura N, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  81. Neural correlates of confidence judgment in retrieved answers: An fMRI study International-presentation

    Yokoyama O, Miura N, Watanabe J, Takemoto A, Uchida S, Sugiura M, Horie K, Sato S, Kawashima R, Nakamura K

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  82. Impact of serotonin transporter gene on negative emotion and brain processing during fear conditioning: an event-related fMRI study International-presentation

    Mizuno T, Sugiura M, Kano M, Miura N, Watanabe J, Hattori T, Sato S, Horie K, Aoki M, Itoyama Y, Kawashima R, Fukudo S

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  83. Highly proficient group of acquired second language shows larger global and regional gray matter volumes than poorly proficient group –A volumetric analysis and a voxel-based morphometry International-presentation

    Taki Y, Okamoto H, Sassa Y, Ikuta N, Jeong H, Horie K, Sato S, Kinomura S, Fukuda H, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  84. Correlations between ischemic white matter lesions and arteriosclerotic risk factors: A voxel-wise multiple regression analysis with automatic tissue classification International-presentation

    Kinomura S, Mok K, Lerch J, Goto R, Taki Y, Sato K, Inoue K, Okada K, Kawashima R, Evans AC, Fukuda H

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  85. Global Likelihood Approach to Time Series Analysis of fMRI Data using Nearest Neighbors Autoregressive Model with Exogenous Variables (NN-ARx) International-presentation

    Watanabe J, Galka A, Kawashima R, Uchida S, Ozaki T

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  86. fMRI Evidence for Language Distance through the Trilingual Translation Processes by Korean-Chinese Bilingual learners of Japanese International-presentation

    Cui S, Horie K, Iwata K, Sassa Y, Jeong H, Yokoyama S, Lee S, Sato S, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  87. Universal Grammar and Instruction Effects on Second Language Grammar Formation: Evidence from fMRI International-presentation

    Yusa N, Koizumi M, Kim J, Saki Y, Kimura N, Uchida S, Yokoyama S, Miura N, Horie K, Sato S, Kawashima R, Hagiwara H

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  88. The left inferior frontal gyrus subserves the same function in first and second language acquisition: An fMRI study of Japanese transitive verbs International-presentation

    Kim J, Koizumi M, Yokoyama S, Uchida S, Okamoto H, Chen B, Kimura N, Sato S, Horie K, Kawashima R

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  89. Relation of subcortical ischemic white matter lesions to cortical atrophy in aging International-presentation

    Mok K, Kinomura S, Ivanov O, Ad-Dab’bagh Y, Lerch J, Singh V, Taki Y, Sato K, Kawashima R, Fukuda H, Evanc AC

    12th Annual Meeting of the Organization for Human Brain Mapping　2006/06/11

  90. 前頭前野の発達

    川島隆太

    第48回日本小児神経学会　2006/06/01

  91. 学習療法 International-presentation

    Kawashima R

    Research and Development of Health Care for Elderly　2006/03/16

  92. 脳を知り，脳を鍛える

    川島隆太

    第34回四国理学療法士学会　2005/11/26

  93. Spontaneous and event-related EEG correlates of concurrent fMRI

    Wan X, Riera J, Kawashima R

    平成17年度生理研研究会「神経科学の道具としての機能的ＭＲＩ研究会」　2005/11/24

  94. Nonlinear Local Electro-Vascular Coupling

    Riera J, Wan X, Jimenez JC, Kawashima R

    平成17年度生理研研究会「神経科学の道具としての機能的ＭＲＩ研究会」　2005/11/24

  95. 認知症の非薬物療法？学習療法？

    川島隆太

    第９回茨城県総合リハビリテーションケア学会　2005/11/20

  96. An effect of word category and morphological complexity on lexical processing in human brain

    Yokoyama S, Miyamoto T, Riera J, Kim J, Akitsuki Y, Iwata K, Yoshimoto K, Horie K, Sato S, Kawashima R

    The 131st General Meeting of The Linguistic Society of Japan　2005/11/20

  97. Situation-based and text-based learning of foreign language: An fMRI study International-presentation

    Jeong H, Sugiura M, Sassa Y, Horie K, Sato S, Kawashima R

    35th Annual Meeting of Society for Neuroscience　2005/11/12

  98. Cortical mechanisms for visual recognition of one's own face and name International-presentation

    Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, Kawashima R

    35th Annual Meeting of Society for Neuroscience　2005/11/12

  99. ヒトにおける様々な高次脳活動について

    川島隆太

    第５回東海北陸作業療法士学会　2005/11/12

  100. 認知症の新しい非薬物療法（学習療法）の開発

    川島隆太

    第３回日本神経疾患医療・福祉従事者学会　2005/11/11

  101. 機能的MRIを用いた計器監視課題における難易度と脳活性状態との関連解析

    三浦 直樹, 高橋 信, 川島 隆太, 北村 正晴, 若林 利男

    ヒューマンインタフェースシンポジウム2005　2005/09/15

  102. fMRI を用いたデジタル・アナログ計器監視時の脳活動比較

    三浦直樹, 渡邉丈夫, 長倉正人, 岩田一樹, 佐藤滋, 堀江薫, 高橋信, 北村正晴, 川島隆太

    第２８回日本神経科学大会　2005/07/26

  103. Neural network involved in the lexical and morphological processing: An fMRI study

    Yokoyama S, Miyamoto T, Kim J, Akitsuki Y, Jeong H, Okamoto H, Sassa Y, Ikuta N, Yoshimoto K, Horie K, Sato S, Kawashima R

    第２８回日本神経科学大会　2005/07/26

  104. 言語コミュニケーションに関与する脳活動

    佐々祐子, 杉浦元亮, 鄭嫣婷, 堀江薫, 佐藤滋, 川島隆太

    第２８回日本神経科学大会　2005/07/26

  105. 日本語を学習した中国語母語話者における、日本語構文の理解に関わる脳活動

    岡本英行, 白晨, 横山悟, 金情浩, 内田信也, 高橋大厚, 中村渉, 佐藤滋, 堀江薫, 川島隆太

    第１０回認知神経科学会学術集会　2005/07/09

  106. 「日本語文処理の即時性について：意味役割の再分析処理より」

    横山悟, 小泉政利, 金情浩, 遊佐典昭, 吉本啓, 川島隆太

    日本認知科学会第22回大会　2005/07/09

  107. Processing of a complex sentence in L1 and L2: An fMRI study International-presentation

    Yokoyama S, Okamoto H, Miyamoto T, Kim J, Iwata K, Uchida S, Yoshimoto K, Horie K, Sato S, Kawashima R

    Second International Workshop on Evolutionary Cognitive Sciences "In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing, and Neurolinguistics".　2005/07/02

  108. Neural network involved in verb processing: An fMRI study International-presentation

    Yokoyama S, Miyamoto T, Kim J, Akitsuki Y, Riera J, Yoshimoto K, Horie K, Sato S, Kawashima R

    Second International Workshop on Evolutionary Cognitive Sciences "In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing, and Neurolinguistics".　2005/07/02

  109. Brain activation associated with the sentence processing: An fMRI study International-presentation

    Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Riera J, Sato S, Horie K, Matsue Y, Kawashima R

    Second International Workshop on Evolutionary Cognitive Sciences "In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing, and Neurolinguistics".　2005/07/02

  110. The brain activation of syntax comprehension in English-Japanese bilinguals: An fMRI study International-presentation

    Okamoto H, Takahashi D, Sassa Y, Ikuta N, Jeong H, Iwata K, Watanabe J, Akitsuki Y, Miura N, Kawashima R

    Second International Workshop on Evolutionary Cognitive Sciences "In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing, and Neurolinguistics".　2005/07/02

  111. Brain activities related to the integration of nouns and numeral classifiers in Japanese: An ERP study International-presentation

    Sakai Y, Iwata K, Riera J, Wan X, Yokoyama S, Shimoda Y, Kawashima R, Yoshimoto K, Koizumi M

    In Pursuit of Language-Brain Interactions: Language Acquisition, Sentence Processing and Neurolinguistics. Center for Evolutionary Cognitive Sciences at the University of Tokyo and Second International Workshop on Evolutionary Cognitive Sciences　2005/07/02

  112. Organizational Principles Relating Human Brain Structure and Function: Insights from the ICBM Probabilistic Atlas International-presentation

    Mazziotta J, Toga A, Evans A, Fox P, Zilles K, Woods R, Lancaster J, Paus T, Amunts K, Iacoboni M, Watkins K, Pol HH, Kawashima R, Mazoyer B, Cannon T, Smith K

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  113. Parietal and Prefrontal Activation Associated with Algebraic Calculation: An fMRI study International-presentation

    Watanabe J, Miura N, Iwata K, Sassa Y, Namikawa Y, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  114. Cortical Representation of Multiple Languages: An fMRI Study of Sentence Comprehension by Late Trilinguals International-presentation

    Jeong H, Sassa Y, Ikuta N, Okamoto H, Yokoyama S, Horie K, Sato S, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  115. Neural network involved in the lexical and morphological processing: An fMRI study International-presentation

    Yokoyama S, Miyamoto T, Kim J, Akitsuki Y, Jeong H, Okamoto H, Sassa Y, Ikuta N, Yoshimoto K, Horie K, Sato S, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  116. The neural network involved in the processing of give and receive expressions: An fMRI study International-presentation

    Yokoyama S, Yusa N, Miyamoto T, Kim J, Jeong H, Okamoto H, Sassa Y, Ikuta N, Yoshimoto K, Horie K, Sato S, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  117. Processing of Scrambled Ditransitive Constructions: An fMRI study International-presentation

    Kim J, Koizumi M, Kimura N, Watanabe J, Yokoyama S, Ikuta N, Uchida S, Sassa Y, Akitsuki Y, Iwata K, Jeong H, Miura N, Yusa N, Sato S, Horie K, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  118. Brain Activation Associated with the Japanese Sentence Comprehension International-presentation

    Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Watanabe Y, Sato S, Horie K, Matsue Y, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  119. Artifact reduction for simultaneous EEG and fMRI recording International-presentation

    Wan X, Iwata K, Riera J, Kitamura M, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping.　2005/06/12

  120. Brain activation during inspection for digital and analog meters: An fMRI study International-presentation

    Miura N, Watanabe J, Nagakura M, Iwata K, Sato S, Horie K, Takahashi M, Kitamura M, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  121. The Correlation of concurrent fMRI and EEG with visual stimuli in humans International-presentation

    Wan X, Riera J, Iwata K, Watanabe J, Kitamura M, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  122. Normal elderly female people have significant positive correlation between cognitive function and volume of the right parahippocampal gyrus. A voxel-based morhometric analysis International-presentation

    Taki Y, Kinomura S, Ito H, Goto R, Inoue K, Sato K, Uchida S, Okada K, Tsuji I, Kawashima R, Fukuda H

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  123. Cortical mechanisms of visual word processing: Comparison of Japanese Kana and Kanji processing during semantic and phonological tasks International-presentation

    Jeong H, Sugiura M, Sassa Y, Bai C, Miyamoto T, Horie K, Sato S, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  124. Low proficient English-Japanese bilinguals comprehend English using different way from Japanese as mother tongue International-presentation

    Okamoto H, Takahashi D, Sassa Y, Ikuta N, Jeong H, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  125. The comparison between low and high proficient English-Japanese bilinguals in comprehension of second language International-presentation

    Okamoto H, Takahashi D, Sassa Y, Ikuta N, Jeong H, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  126. Communicative speech production activates the frontal and anterior cingulate cortices: An fMRI study International-presentation

    Sassa Y, Sugiura M, Jeong H, Miura N, Iwata K, Akitsuki Y, Yokoyama S, Watanabe J, Ikuta N, Okamoto H, Uchida S, Riera J, Horie K, Sato S, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  127. The Japanese Standard Brain Elastically Optimized in Each Age Group International-presentation

    Sato K, Kinomura S, Goto R, Taki Y, Uchida S, Ito H, Inoue K, Okada K, Furumoto M, Kawashima R, Hiroshi Fukuda

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  128. 11th Annual Meeting of the Organization for Human Brain Mapping International-presentation

    Miyazawa S, Akitsuki Y, Iwata K, Suzuki D, Matsuda Y, Iwasaki S, Sato S, Horie K, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  129. Brain activation compared the Paced Visual Serial Addition Task with the simple addition task International-presentation

    Uchida S, Watanabe J, Iwata K, Kinomura S, Sato K, Fukuda H, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  130. Orthogonality of Anterior and Posterior Alpha EEG Activities International-presentation

    Iwata K, Riera J, Wan X, Aubert E, Miwakeichi F, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  131. A first-order bottom-up approach at the micro-columnar level International-presentation

    Riera J, Wan X, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  132. Subcortical ischemic lesions detected with tissue classification technique from 3D magnetic resonance images: An aging effect International-presentation

    Kinomura S, Lerch J, Signh V, Sato K, Taki Y, Goto R, Inoue K, Uchida S, Ito H, Okada K, Tsuji I, Kawashima R, Evans AC, Fukuda H

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  133. The role of the Broca’s area and left parietal region during processing of a passive sentence in Japanese: An event-related fMRI study International-presentation

    Yokoyama S, Watanabe J, Iwata K, Sassa Y, Akitsuki Y, Miura N, Jeong H, Ikuta N, Okamoto H, Haji T, Usui N, Taira M, Nakamura W, Sato S, Horie K, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  134. Effects of motion and the body part on activation of the left and right cortical networks for visual self-recognition: An event-related fMRI study International-presentation

    Sugiura M, Sassa Y, Jeong H, Miura N, Iwata K, Akitsuki Y, Horie K, Sato S, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  135. Cortical activation involved in the processing of passive sentences in L1 and L2: A functional Magnetic Resonance Imaging study International-presentation

    Yokoyama S, Iwata K, Kim J, Jeong H, Okamoto H, Uchida S, Sassa Y, Ikuta N, Nakamura W, Yoshimoto K, Horie K, Sato S, Kawashima R

    11th Annual Meeting of the Organization for Human Brain Mapping　2005/06/12

  136. 脳を知り、脳を育む

    川島隆太

    第43回日本小児歯科学会大会　2005/05/26

  137. アルツハイマー病の非薬物療法？学習療法について

    川島隆太

    第46回日本神経学会総会　2005/05/25

  138. 脳科学の視点から新たな認知リハビリテーションの提案

    川島隆太

    第101回日本精神神経学会総会　2005/05/18

  139. 脳を知り，脳を守り，脳を育む

    川島隆太

    第3回東北大学バイオサイエンスシンポジウム　2005/05/16

  140. 脳を知り、脳を守る

    川島隆太

    日本化学会第85回春季年会　2005/03/26

  141. The Correlation of concurrent fMRI and EEG with visual stimuli in humans

    Wan X, Riera J, Iwata K, Watanabe J, Kitamura M, Kawashima R

    CREST-RIKEN Workshop "Real-Time Computing and Neural Dynamics in the Brain"　2005/03/02

  142. The Correlation of concurrent fMRI and EEG with visual stimuli in humans International-presentation

    Wan X, Riera J, Iwata K, Watanabe J, Kitamura M, Kawashima R

    The 5th International Symposium on Future Medical Engineering based on Bio-nanotechnology 21st Century Center of Excellence (COE) Program　2005/02/15

  143. イメージングによる脳と心の研究

    川島隆太

    第９回日本心療内科学会学術大会　2005/01/29

  144. 在宅健常高齢者に対する認知トレーニング介入効果の検討

    内田信也, 川島隆太, 寶澤篤, 大森芳, 辻一郎

    第63回日本公衆衛生学会総会　2004/10/27

  145. 脳高次機能イメージングの最前線

    川島隆太

    第22回日本脳腫瘍学会　2004/10/17

  146. 脳を知り、脳を育む

    川島隆太

    第16回全国生涯学習フェスティバル　2004/10/12

  147. Functional organization of the human inferior frontal cortex involved in language processingsentences International-presentation

    Sassa Y, Jeong H, Okamoto H, Kawashima R

    An International Workshop on Language, Brain and Cognition: Linguistic Science at Interdisciplinary Crossroads　2004/10/11

  148. 脳を鍛える〜痴呆の治療と予防〜

    川島隆太

    日本作業療法士協会第37回全国研修会　2004/10/10

  149. 機能的MRIを用いたメータ監視作業時の脳活動解析

    三浦 直樹, 渡邊 丈夫, 高橋 信, 川島 隆太, 北村 正晴

    ヒューマンインタフェースシンポジウム2004　2004/10/06

  150. タブレット入出力デバイスを利用した脳画像解析支援システムの開発

    ウォン ヅー, ポー ケルビン, 高橋 信, 北村 正晴, 川島 隆太

    ヒューマンインタフェースシンポジウム2004　2004/10/06

  151. Step for fusion of EEG and fMRI International-presentation

    Wan X, Iwata K, Riera J, Kitamura M, Kawashima R

    57th Annual Meeting of American Clinical Neurophysiology Society　2004/09/29

  152. 情動に関するfunctional MRI？報酬に対する脳活動変化の文脈依存性

    秋月祐子, 川島隆太

    第27回日本神経科学大会　2004/09/21

  153. 代数的計算の脳活動: fMRI研究

    渡辺丈夫, 三浦直樹, 岩田一樹, 佐々祐子, 浪川幸彦, 川島隆太

    第27回日本神経科学大会　2004/09/21

  154. fMRIおよびNIRSデータの融合：ボトムアップアプローチに基づく動的モデル

    岩田一樹, Jorge Riera, 川島隆太

    第27回日本神経科学大会　2004/09/21

  155. fMRIによる文理解に関わる脳活動の研究

    生田奈穂, 秋月祐子, 佐々祐子, 渡辺丈夫, 岩田一樹, 三浦直樹, 岡本英行, 佐藤滋, 松江克彦, 川島隆太

    第27回日本神経科学大会　2004/09/21

  156. 第一言語・第二言語の理解に関わる脳活動領域の特定

    横山悟, 内田信也, 岩田一樹, 金情浩, 岡本英行, 鄭嫣婷, 中村渉, 堀江薫, 佐藤滋, 川島隆太

    第27回日本神経科学大会　2004/09/21

  157. L1、L2及びL3間の言語学的類似性と関連する神経機構

    鄭嫣婷, 岩田一樹, 渡辺丈夫, 佐々祐子, 生田奈穂, 秋月祐子, 三浦直樹, 岡本英行, 横山悟, Jorge Riera, 土師知己, 臼井信男, 泰羅雅登, 佐藤滋, 川島隆太

    第27回日本神経科学大会　2004/09/21

  158. 作業記憶課題における刺激提示速度変化に伴う脳活動量の検討

    内田信也, 岩田一樹, 渡辺丈夫, 佐々祐子, 三浦直樹, 木之村重男, 佐藤和則, 福田寛, 川島隆太

    第27回日本神経科学大会　2004/09/21

  159. Comprehension of passive sentences in Japanese: An fMRI study International-presentation

    Yokoyama S, Watanabe J, Iwata K, Sassa Y, Miura N, Jeong H, Ikuta N, Akitsuki Y, Okamoto H, Haji T, Usui N, Taira M, Nakamura W, Sato S, Horie K, Kawashima R

    The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004/09/12

  160. The role of linguistic typology in sentence comprehension by multilinguals: An fMRI study International-presentation

    Jeong H, Iwata K, Watanabe J, Sassa Y, Akitsuki Y, Ikuta N, Okamoto H, Yokoyama S, Miura N, Riera J, Haji T, Usui N, Taira M, Sato S, Kawashima R

    The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004/09/12

  161. The brain activation of Japanese-English bilingual in sentence comprehension: An fMRI study International-presentation

    Okamoto H, Takahashi D, Sassa Y, Sugiura M, Ikuta N, Iwata K, Watanabe J, Akitsuki Y, Miura N, Matsue K, Kawashima R

    The 4th International Forum on Language, Brain, and Cognition: Cognition, Brain, and Typology: Towards a Synthesis　2004/09/12

  162. 感性のブレインマッピング

    川島隆太

    第６回日本感性工学会大会　2004/09/09

  163. 脳を知り、脳を守り、脳を育む

    川島隆太

    日本カイロプラクティス徒手医学会第６回学術大会　2004/09/04

  164. 日英語における受動文理解に関わる脳活動領域の研究―日本語母語話者を対象としたfMRI実験より

    横山悟, 内田信也, 岩田一樹, キムジョンホ, ジョンヒョンジョン, 岡本英行, 渡辺丈夫, 佐々佑子, 三浦直樹, 秋月祐子, 生田奈穂, ホルヘ・リエラ, ワンシャオホン

    思考と言語研究会　2004/07/09

  165. An event-related fMRI study of how active and passive sentences are comprehended in Japanese International-presentation

    Yokoyama S, Nakamura W, Watanabe J, Sassa Y, Iwata K, Akitsuki Y, Miura N, Jeong H, Ikuta N, Riera J, Okamoto H, Usui N, Taira M, Sato S, Horie K, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  166. The role of the left frontal cortex during judgment of grammatical violation: An fMRI study International-presentation

    Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Iwata K, Ikuta N, Miura N, Okamoto H, Sato S, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  167. Brain activation during rapid listening with an fMRIstudy International-presentation

    Sassa Y, Akitsuki Y, Usui N, Taira M, Kawashima R, Tanaka T, Kubota K

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  168. Parietal and Prefrontal Activation are involved in Algebraic Calculation: An fMRI study International-presentation

    Watanabe J, Miura N, Iwata K, Sassa Y, Namikawa Y, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  169. A bottom-up approach for fMRI and NIRs fusion. I- Theory International-presentation

    Riera J, Iwata K, Jimenez JC, Ozaki T, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  170. fMRI activation maps based on the NN-ARX model International-presentation

    Riera J, Bosch J, Yamashita O, Kawashima R, Sadato N, Ozaki T

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  171. A de-blurring method to remove the effect of nuisance tissues from NIRs signals International-presentation

    Riera J, Ripoll J, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  172. An fMRI study of reading of ancient writings International-presentation

    Miura N, Watanabe J, Iwata K, Sassa Y, Riera J, Tsuchiya H, Takahashi M, Kitamura M, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  173. FMRI Evidence for the Neural Correlates of the Typological Differences among L1, L2, and L3 International-presentation

    Jeong H, Iwata K, Watanabe J, Sassa Y, Akitsuki Y, Ikuta N, Miura N, Okamoto H, Yokoyama S, Riera J, Haji T, Usui N, Taira M, Horie K, Sato S, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  174. Brain activation with the change of cognitive load during Paced Visual Serial Addition Task International-presentation

    Uchida S, Iwata K, Watanabe J, Sassa Y, Miura N, Fukuda H, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  175. Brain activities during evaluation of color combination attractiveness of female faces with makeup: An event-related fMRI study International-presentation

    Akitsuki Y, Iwata K, Sassa Y, Miura N, Ikuta N, Jeong H, Maeda Y, Matsue Y, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  176. Brain activities associated with repetition priming effects: An event-related fMRI study International-presentation

    Akitsuki Y, Sassa Y, Nakamura M, Awata S, Matsuoka H, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  177. Changes in the activation pattern during the course of sentence comprehension International-presentation

    Ikuta N, Iwata K, Sassa Y, Watanabe J, Akitsuki Y, Miura N, Okamoto H, Riera J, Sato S, Matsue Y, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  178. Brain activation during rapid listening with an fMRI study: Effects of training International-presentation

    Usui N, Haji T, Nose I, Sassa Y, Kawashima R, Taira M, Tanaka T, Kubota K

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  179. Aging in morphometry - significance vs. inclination of gray matter change International-presentation

    Goto R, Kinomura S, Sato K, Taki Y, Inoue K, Ito H, Kawashima R, Fukuda H

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  180. Automatic detection of subcortical ischemic lesion from 3-D MRI data in the aged brain International-presentation

    Kinomura S, Lerch J, Zijdenbos AP, Sato K, Taki Y, Goto R, Inoue K, Uchida S, Tsuji I, Kawashima R, Evans AC, Fukuda H

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  181. Standard brain for each age group generated by aging simulation technique International-presentation

    Sato K, Kinomura S, Goto R, Taki Y, Uchida S, Inoue K, Ito H, Kawashima R, Fukuda H

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  182. Depressive subjects have smaller gray matter volume in the prefrontal cortex comparing with normal subjects: A voxel-based morphometry International-presentation

    Taki Y, Kinomura S, Goto R, Inoue K, Sato K, Uchida S, Tsuji I, Awata S, Kawashima R, Fukuda H

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  183. An fMRI study of scrambling effects on sentence comprehension International-presentation

    Kim J, Koizumi M, Ikuta N, Fukumitsu Y, Akitsuki Y, Iwata K, Jeong H, Miura N, Okamoto H, Sassa Y, Watanabe J, Yokoyama S, Yusa N, Sato S, Horie K, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  184. A bottom-up approach for fMRI and NIRs fusion. II- Application to real data International-presentation

    Iwata K, Riera J, Kawashima R

    10th Annual Meeting of the Organization for Human Brain Mapping　2004/06/13

  185. 脳を知り、脳を育む？脳機能イメージング研究の最前線？

    川島隆太

    電子情報通信学会ニューロコンピューティング研究会　2004/05/24

  186. 脳を知り、脳を守り、脳を育む

    川島隆太

    第58回日本栄養・食糧学会大会　2004/05/21

  187. 脳を知り、脳を育む

    川島隆太

    福岡市民大学講座　2004/05/12

  188. 家庭が子どもの脳を育てる

    川島隆太

    心の教育・女性フォーラム　2004/05/08

  189. 脳機能から見たコミュニケーション：理論的考察

    川島隆太

    第１５回日本発達心理学会大会　2004/03/21

  190. 受動文の理解における脳内での処理の負荷

    横山悟, 渡辺丈夫, 佐々祐子, 岩田一樹, 三浦直樹, 秋月祐子, 鄭嫣婷, 生田奈穂, ホルヘ・リエラ, 岡本英行, 土師知己, 臼井信男, 泰羅雅登, 中村渉, 佐藤滋, 堀江薫

    言語処理学会第10回年次大会　2004/03/15

  191. SPECT画像による痴呆症の診断システムの研究 (1)機械学習による自動診断

    松本怜, 三浦直樹, 高橋信, 北村正晴, 川島隆太, 福田寛

    第37回日本エム・イー学会東北支部大会　2003/11/15

  192. SPECT画像による痴呆症の診断システムの研究 (2)医師との診断戦略の比較

    室岡澄子, 松本怜, 三浦直樹, 高橋信, 北村正晴, 川島隆太, 福田寛

    第37回日本エム・イー学会東北支部大会　2003/11/15

  193. 脳を知り、脳を育む

    川島隆太

    第29回日本行動療・学会　2003/10/24

  194. 脳機能最先端科学が明らかにしはじめたこころと癒しのメカニズム

    川島隆太

    第４回癒しの環境研究会全国大会　2003/08/27

  195. ブレインイメージングによる顔の個体識別の研究

    川島隆太

    第26回日本神経科学大会　2003/07/23

  196. fMRIを用いた文法処理に伴う左前頭葉領域の脳賦活

    佐々祐子, 杉浦元亮, 渡邊丈夫, 秋月祐子, 岩田一樹, 生田奈穂, 三浦直樹, 岡本英行, 佐藤滋, 福田寛, 川島隆太

    第26回日本神経科学大会　2003/07/23

  197. 主語、目的語、動詞の処理に関わる脳領域

    生田奈穂, 杉浦元亮, 佐々祐子, 渡邊丈夫, 秋月祐子, 岩田一樹, 三浦直樹, 岡本英行, 渡部芳彦, 佐藤滋, 松江克彦, 川島隆太

    第26回日本神経科学大会　2003/07/23

  198. Brain activities during evaluation of attractiveness of clothes color combination: An event-related fMRI study

    秋月祐子, 杉浦元亮, 渡邊丈夫, 佐々祐子, 粟田主一, 松岡洋夫, 前田泰弘, 松江克彦, 福田寛, 川島隆太

    第26回日本神経科学大会　2003/07/23

  199. ヒト頭頂葉皮質は舌の三次元的運動に関係している機能的磁気共鳴画像法による研究

    渡邊丈夫, 杉浦元亮, 前田泰弘, 松江克彦, 福田寛, 川島隆太

    第26回日本神経科学大会　2003/07/23

  200. 近赤外線分光法によるヘモグロビン濃度とfMRIによるBOLD信号との相関

    岩田一樹, 杉浦元亮, 渡邊丈夫, 秋月祐子, 佐々祐子, 渡部芳彦, 生田奈穂, 岡本英行, 三浦直樹, 前田泰弘, 松江克彦, 川島隆太

    第26回日本神経科学大会　2003/07/23

  201. MRIを用いたヒトの灰白質及び白質の体積、形態変化と年齢及び脳血管障害危険因子との相関

    瀧靖之, 後藤了以, 佐藤和則, 木之村重男, 小野修一, 川島隆太, 福田寛

    第26回日本神経科学大会　2003/07/23

  202. Developing your brain by yourself -developing a sound brain and using it wisely International-presentation

    Kawashima R

    2003 iEARN International Conference　2003/07/20

  203. 学習療法における教材音読が脳活動に与える影響について

    臼井信男, 川島隆太, 大野好之, 杉本幸司, 泰羅雅登

    日本認知心理学会第１回大会　2003/06/27

  204. The human parietal cortex is involved in Three-dimensional movements of the tongue: An fMRI study International-presentation

    Watanabe J, Sugiura M, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  205. Age-effects on Brain perfusion SPECT in normal subjects : a comparison between standardization with and without anatomical information of MRI International-presentation

    Goto R, Kinomura S, Sato K, Inoue K, Sato T, Kawashima R, Fukuda H

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  206. Subcortical ischemic change of the brain correlates with cortical gray matter volume reduction: A morphometric MRI study International-presentation

    Kinomura S, Goto R, Inoue K, Taki Y, Sato K, Kawashima R, Fukuda H

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  207. Cortical thinning in normal aging International-presentation

    Lerch J, Zijdenbos A, Goto R, Taki Y, Sato K, Kawashima R, Fukuda H, Evans A

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  208. Deformation field as a representation of brain structural changes with aging International-presentation

    Sato K, Kinomura S, Taki Y, Goto R, Inoue K, Watanabe J, Ono S, Fukuda H, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  209. Voxel based morphometry of age related structural change of gray matter for each decade in normal male subjects International-presentation

    Taki Y, Goto R, Evans A, Sato K, Kinomura S, Ono S, Kawashima R, Fukuda H

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  210. An fMRI study of sentence reading International-presentation

    Ikuta N, Sugiura M, Sassa Y, Watanabe J, Akitsuki Y, Iwata K, Miura N, Okamoto H, Watanabe Y, Sato S, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  211. An fMRI study of reading aloud International-presentation

    Miura N, Iwata K, Watanabe J, Sugiura M, Akitsuki Y, Sassa Y, Ikuta N, Okamoto H, Watanabe Y, Riera J, Maeda Y, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  212. Brain areas involved in understanding of second language in Japanese: An fMRI study International-presentation

    Okamoto H, Takahashi T, Sugiura M, Sassa Y, Ikuta N, Iwata K, Watanabe J, Akitsuki Y, Miura N, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  213. Brain activities during evaluation of attractiveness of color combination: An event-related fMRI study International-presentation

    Akitsuki Y, Sugiura M, Watanabe J, Sassa Y, Awata S, Matsuoka H, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  214. Brain Activation Related to Spatial Divided Attention : An fMRI study International-presentation

    Iwata K, Sugiura M, Watanabe J, Riera J, Akitsuki Y, Sassa Y, Watanabe Y, Miura N, Ikuta N, Okamoto H, Maeda Y, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  215. Brain Regions Involved in Appetite: An Event-related fMRI Study International-presentation

    Watanabe Y, Sugiura M, Watanabe J, Akitsuki Y, Sassa S, Iwata K, Ikuta N, Miura N, Imaizumi O, Watanabe M, Matsue Y, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  216. A method to estimate neuronal dynamic from BOLD signals International-presentation

    Riera J, Watanabe J, Iwata K, Miura N, Aubert E, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  217. Brain activation of different grammatical processing in Japanese sentences: An event related fMRI study International-presentation

    Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Iwata K, Ikuta N, Miura N, Okamoto H, Sato S, Fukuda H, Kawashima R

    9th International Conference on Functional Mapping of the Human Brain　2003/06/18

  218. 言語機能の脳イメージング

    川島隆太

    第４回日本言語聴覚士協会学術集会　2003/06/07

  219. 学習療法の理論的背景と方法論

    川島隆太

    第14回日本発達心理学会　2003/03/26

  220. 脳を知り、脳を守り、脳を育てる

    川島隆太

    平成15年電気学会全国大会　2003/03/17

  221. 脳画像のニューロインフォマティクス

    川島隆太

    第96回つくばブレインサイエンスセミナー　2003/02/18

  222. 脳機能画像データベースシステムの開発

    川島隆太

    第４回IEEE&SICEセミナー　2003/01/29

  223. 四則演算の脳イメージング？大人と子どもの比較？

    川島隆太, 泰羅雅登

    認知と記憶の脳内メカニズム　2003/01/16

  224. Neural basis of learning therapy International-presentation

    Kawashima R

    1st International Symposium for Learning Therapy　2002/12/14

  225. 視覚的注意の効率的配分に関係する脳領域

    岩田一樹, 杉浦元亮, 渡邉丈夫, Jorge Riera, 三浦直樹, 秋月祐子, 佐々祐子, 渡部芳彦, 生田奈穂, 岡本英行, 前田泰弘, 松江克彦, 川島隆太

    第２回感性福祉学会　2002/11/15

  226. 視線感知の脳内メカニズム？心の理論の解明をめざして？

    川島隆太

    第26回日本神経心理学会総会　2002/09/12

  227. ヒト脳において世界はどのように構成されているか: fMRI研究

    杉浦元亮, 渡邉丈夫, 秋月祐子, 佐々祐子, 松江克彦, 川島隆太

    第25回日本神経科学大会　2002/07/07

  228. Effect of alcohol on the activation of the human prefrontalcortex during NO-GO performances: An event-related fMRI study

    渡邉丈夫, 杉浦元亮, 井上健太郎, 鐘ヶ江孝, 塚本正次郎, 泰羅雅登, 川島隆太

    第25回日本神経科学大会　2002/07/07

  229. fMRIによる統語処理と意味処理の機能局在化の解析 International-presentation

    佐々祐子, 杉浦元亮, 渡辺丈夫, 秋月祐子, 佐藤滋, 福田寛, 川島隆太

    第25回日本神経科学大会　2002/07/07

  230. Attractiveness of color combination: An event-related fMRI

    秋月祐子, 杉浦元亮, 渡辺丈夫, 佐々祐子, 粟田主一, 松岡洋夫, 前田泰弘, 松江克彦, 福田寛, 川島隆太

    第25回日本神経科学大会　2002/07/07

  231. 大脳による随意運動の制御

    川島隆太

    第８回東海脳神経核医学研究会　2002/07/06

  232. Neuroimaging can be applied to cognitive rehabilitation –concepts and clinical implementations of learning therapy International-presentation

    Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  233. Differential activation of temporoparietal structures during recognition of famous names and that of personally familiar names: An event-related fMRI study International-presentation

    Sugiura M, Watanabe J, Satoh T, Akitsuki Y, Sassa Y, Imaizumi O, Matsue Y, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  234. Functional anatomy of articulation International-presentation

    Sugiura M, Watanabe J, Sassa Y, Akitsuki Y, Maeda Y, Imaizumi O, Matsue Y, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  235. Brain areas associated with humor appreciation International-presentation

    Satoh T, Sugiura M, Watanabe J, Maeda Y, Matsue Y, Harada A, Satoh K, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  236. Activation of the left parietal cortex during imagery of taste: An event-related fMRI study International-presentation

    Horino S, Sugiura M, Satoh T, Watanabe J, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  237. The different brain network of two groups - relative pitch and perfect pitch International-presentation

    Yamashita K, Sugiura M, Watanabe J, Akitsuki Y, Watanabe T, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  238. Activation of the right orbitotemporal junction during reading a story: An fMRI study International-presentation

    Sugiura M, Watanabe J, Satoh K, Harada A, Yamaguchi K, Itoh M, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  239. A brain network involved in deception: An fMRI study International-presentation

    Kobayashi N, Sugiura M, Watanabe J, Hagimoto S, Horino S, Satoh T, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  240. What factor is associated with global and local changes of white matter in human brain? International-presentation

    Taki Y, Goto R, Alan Evans, Ph.D, Alex Zijdenbos, Peter Neelin, Jason Lerch, Sato K, Ono S, Kinomura S, Nakagawa M, Sugiura M, Watanabe J, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  241. Effect of alcohol on the activation of the human prefrontal cortex during NO-GO performances: An event-related fMRI study International-presentation

    Watanabe J, Sugiura M, Inoue K, Kanegae T, Tsukamoto S, Taira M, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  242. Difference in brain activation during hearing Japanese sentences containing grammatical error or semantic anomaly International-presentation

    Sassa Y, Sugiura M, Watanabe J, Akitsuki Y, Sato S, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  243. Cross-generational Changes in Brain Shape of Japanese International-presentation

    Sato K, Taki Y, Kinomura S, Watanabe J, Sugiura M, Harada A, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  244. The left prefrontal cortex plays an important role in imagination International-presentation

    Yomogita Y, Sugiura M, Watanabe J, Akitsuki Y, Sassa Y, Sato T, Imaizumi O, Matsue Y, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  245. 8th International Conference on Functional Mapping of the Human Brain International-presentation

    Akitsuki Y, Sugiura M, Watanabe J, Yamashita K, Awata S, Matsuoka H, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  246. Automatic Brain Tissue Segmentation Method from MRI T1-weighted Data International-presentation

    Miura N, Taneda A, Shida K, Kawashima R, Fukuda H, Kawazoe Y, Shimizu T

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  247. Morphological analysis of MR brain images by spherical harmonics International-presentation

    Hakoda N, Miura N, Shida K, Kawashima R, Fukuda H, Kawazoe Y, Shimizu T

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  248. A principal component analysis on whole brain shape utilizing a spherical harmonics expansion International-presentation

    Shida K, Hakoda N, Miura N, Kawashima R, Shimizu T, Fukuda H, Kawazoe Y

    8th International Conference on Functional Mapping of the Human Brain　2002/06/02

  249. 3次元頭部MRI画像脳領域自動抽出法の提案とその性能評価

    三浦直樹, 種田晃人, 志田和人, 川島隆太, 川添良幸, 福田寛, 清水俊夫

    情報処理学会第64回全国大会　2002/03/12

  250. 球面調和関数展開による脳表面形状特性解析

    箱田直子, 三浦直樹, 志田和人, 川島隆太, 川添良幸, 福田寛, 清水俊夫

    情報処理学会第64回全国大会　2002/03/12

  251. Functional role of the fronto-polar prefrontal cortex in performing the tasks related to the prefrontal cortex: An fMRI study International-presentation

    Taira M, Kawashima R, Kubota K

    31st Annual Meeting for Society for Neuroscience　2001/11/10

  252. Brain networks for communication and deception International-presentation

    Sugiura M, Kobayashi N, Watanabe J, Hagimoto S, Horino S, Sato T, Maeda Y, Matsue Y, Fukuda H, Kawashima R

    31st Annual Meeting for Society for Neuroscience　2001/11/10

  253. 脳科学からみた長寿の工夫

    川島隆太

    第14回日本健康心理学会　2001/11/03

  254. 脳のはたらきを画像でみる

    川島隆太

    第16回「大学と科学」シンポジウム　2001/10/27

  255. 個人的知り合いと有名人の名前の認知に関与する脳領域: An event-related fMRI

    杉浦元亮, 渡邉丈夫, 佐藤輝幸, 佐藤優子, 前田泰弘, 松江克彦, 原田淳, 佐藤和則, 福田寛, 川島隆太

    第24回日本神経科学・第44回日本神経化学合同大会　2001/09/26

  256. 音程と音量認知の大脳メカニズム

    山下圭一, 杉浦元亮, 渡邉丈夫, 秋月祐子, 渡辺高志, 前田泰弘, 松江克彦, 福田寛, 川島隆太

    第24回日本神経科学・第44回日本神経化学合同大会　2001/09/26

  257. ユーモアの主観的情動体験に関係する脳領域: An event-related fMRI

    佐藤輝幸, 杉浦元亮, 渡邉丈夫, 佐藤優子, 前田泰弘, 松江克彦, 原田淳, 佐藤和則, 萩本繁, 小林奈津子, 堀野智史, 福田寛, 川島隆太

    第24回日本神経科学・第44回日本神経化学合同大会　2001/09/26

  258. The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study

    渡邉丈夫, 杉浦元亮, 佐藤和則, 佐藤優子, 前田泰弘, 松江克彦, 福田寛, 川島隆太

    第24回日本神経科学・第44回日本神経化学合同大会　2001/09/26

  259. 報酬に対する脳活動変化の文脈依存性: An event-related fMRI

    秋月祐子, 杉浦元亮, 渡辺丈夫, 山下圭一, 粟田主一, 松岡洋夫, 前田泰弘, 松江克彦, 福田寛, 川島隆太

    第24回日本神経科学・第44回日本神経化学合同大会　2001/09/26

  260. Can we measure spontaneous thinking? Regional amplitude of low-frequency fluctuation of cortical BOLD signal during resting state and task execution International-presentation

    Sugiura M, Kawashima R, Watanabe J, Sato Y, Maeda Y, Matsue Y, Sato K, Harada A, Fukuda H

    7th International Conference on Functional Mapping of the Human Brain　2001/06/10

  261. Different functional roles of human frontal and parietal cortices in memory-guided saccade: An event-related fMRI study International-presentation

    Sugiura M, Kawashima R, Watanabe J, Sato Y, Maeda Y, Matsue Y, Sato K, Harada A, Fukuda H

    7th International Conference on Functional Mapping of the Human Brain　2001/06/10

  262. An fMRI study of simple arithmetic –Comparison between children and adults International-presentation

    Kawashima R, Taira M, Okita K, Tajima N, Yoshida H, Sasaki T, Sugiura M, Watanabe J, Inoue K, Fukuda H

    7th International Conference on Functional Mapping of the Human Brain　2001/06/10

  263. A functional MRI study of prospective memory International-presentation

    Okuda J, Fujii T, Umetsu A, Tsukiura T, Suzuki M, Nagasaka T, Yanagawa I, Suzuki K, Yamadori A, Takahashi S, Kawashima R, Fukuda H

    7th International Conference on Functional Mapping of the Human Brain　2001/06/10

  264. Normal aging and sexual dimorphism of Japanese brain International-presentation

    Goto R, Kawashima R, Zijdenbos A, Neelin P, Lerch J, Sato K, Ono S, Nakagawa M, Taki Y, Sugiura M, Watanabe J, Fukuda H, Evans A

    7th International Conference on Functional Mapping of the Human Brain　2001/06/10

  265. Functional MR imaging of cue-invariant shape perception International-presentation

    Nakamura K, Kawashima R, Hanazawa A, Sato Y, Sugiura M, Watanabe J, Sato K, Maeda Y, Matsue Y, Fukuda H

    7th International Conference on Functional Mapping of the Human Brain　2001/06/10

  266. Elevation of systolic blood pressure accelerates shrinkage of the gray matter International-presentation

    Taki Y, Kawashima R, Goto R, Sato K, Ono S, Kinomura S, Nakagawa M, Sugiura M, Watanabe J, Fukuda H

    7th International Conference on Functional Mapping of the Human Brain　2001/06/10

  267. 注意機構の機能画像

    川島隆太

    第42回日本神経学会　2001/05/11

Show all Show first 5

Industrial Property Rights 9

  1. 小動物用の脳計測用電極ユニットとそれを用いた測定システム

    特許5843201

    Property Type: Patent

  2. ユーザ見守りシステムおよびユーザ見守り方法

    特許6328834

    Property Type: Patent

  3. コンピュータプログラム、サーバ装置、タブレット型電子機器およびテレビジョン装置接続用電子機器

    特許6284171

    Property Type: Patent

  4. 情報処理プログラム、情報処理装置、情報処理方法及び情報処理システム

    特許6055186

    Property Type: Patent

  5. 情報処理プログラム、情報処理装置、情報処理方法及び情報処理システム

    特許6045175

    Property Type: Patent

  6. アイウエア（特願2012-122349の分割）

    特許5661067

    Property Type: Patent

  7. アイウエア

    特許5661067

    Property Type: Patent

  8. 車両用自律神経機能診断装置、車両用自律神経機能診断方法

    特許5390851

    Property Type: Patent

  9. 複数脳賦活観測システム

    5280494

    Property Type: Patent

Show all Show first 5

Research Projects 39

  1. 脳高次機能イメージング研究 Competitive

    2006/03 - Present

  2. 脳ダイナミクス研究 Competitive

    2006/03 - Present

  3. 脳科学と教育 Competitive

    2006/03 - Present

  4. Quantifying oral communication quality by measuring inter-brain synchronization using fNIRS hyperscanning

    KAWASHIMA Ryuta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/07/18 - 2021/03/31

    More details Close

    The purpose of this project was to investigate the difference between face-to-face and online communication by measuring inter-brain synchronization using portable fNIRS hyperscanning. We recruited 30 healthy university students as participants. Five participants with the same sex made a group. We arranged two group conditions (face-to-face communication group and online communication group). Regions of interest were the right dorsal medial prefrontal cortex (DMPFC) and the left dorsal lateral prefrontal cortex (DLPFC) to measure brain activities reflecting social cognition and linguistic thinking. We calculated a wavelet transform coherence to evaluate a strength of the inter-brain synchronization. We found the strong inter-brain synchronization in the DMPFC in the face-to-face communication group compared to the online communication group in the period of 8-10 seconds. And we found the strong inter-brain synchronization in the left DLPFC in the period of 21-24 seconds.

  5. R&D for bio-feedback cognitive training system

    KAWASHIMA RYUTA

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2015/04/01 - 2017/03/31

    More details Close

    he purpose of this research was to develop bio-feedback system for controlling one’s appetite using ultra-small near infrared spectroscopy (NIRS) system. Individual analysis of functional MRI data during appetite control task showed activation of cortical network including the bilateral prefrontal cortex, where our target of the NIRS measurements. We, then, applied our bio-feedback system during appetite control tasks, however, we faced a few significant problems for the measured NIRS data. Therefore, extra-development for the system was needed, and, unfortunately, there was no remaining time left to study beneficial effects by our bio-feedback system.

  6. The neural substrates of decision making in patients with irritable bowel syndrome an fMRI study.

    Aizawa Emiko, FUKUDO SHIN, MUSHIAKE HAJIME, KAWASHIMA RYUTA, SUGIURA MOTOAKI, KOCHIYAMA TAKANORI, SATO YASUHIRO, SEKIGUCHI ATSUSHI, KANAZAWA MOTOYORI, KANO MICHIKO, MORISHITA JOE, KOTOZAKI YUKA

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: National Center of Neurology and Psychiatry

    2013/04/01 - 2017/03/31

    More details Close

    Patients with irritable bowel syndrome (IBS) exhibited an exaggerated sensorimotor function of the gastrointestinal tract in response to stress. However, the emotion-cognition sequence is largely unknown for IBS. We hypothesized that brain processing in individuals with IBS, during decision making, is different from that of healthy controls, due to increased activity of the insula and anterior cingulate cortex (ACC) as well as altered connectivity among brain regions. The results suggested that IBS subjects had significantly more advantageous card selections and gaining money.The dorsolateral prefrontal cortex (DLPFC) in IBS subjects is likely to be activated during decision making under ambiguity. Moreover, dynamic causal modeling analysis during decision making revealed significantly different connectivity in subjects with IBS, compared with controls. These findings suggested that gut feeling is involved in decision making individuals with IBS.

  7. Study on the adaptive performance when facing unexpected situations

    Takahashi Makoto, MIURA Naoki, KAWASHIMA Ryuta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

    More details Close

    In this study, cognitive,psychological and brain studies have performed to find the method to improve the capability to deal with unexpected situations in nuclear power plant. Two simulation environments (Micro world simulation and PC-based Nuclear power plant simulator ) have been utilized to evaluate the human performance when facing unexpected situations. It has been confirmed through cognitive experiments using Micro world simulation that the task performance facing severe situation is positively correlated with the one for normal situations. It has also been confirmed that human performance for unexpected situation tends to improve when the subjects were given with the deep knowledge.Based on the above findings, it is concluded that the important insights have been obtained for the evaluation of human behavior when facing unexpected events and for the improvements of operation training.

  8. An information correction mechanism during sentence comprehension

    Takahashi Kei, KAWASHIMA Ryuta, YOSHIMOTO Kei, YOKOYAMA Satoru, HASHIMOTO Yosuke, Potoki Anna

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (A)

    Institution: Tohoku University

    2011/04/01 - 2016/03/31

    More details Close

    The aim of current study was to clarify correct wrong linguistic information especially slip of tongue and re-comprehend it smoothly. Correction of wrong information is thought to be an essential function during communication. In this study, psychological and fMRI experiments were conducted to reveal the correct function. These results indicates that correction and short-term memory or working memory mutually works during real-time language processing.

  9. Role of Pax6 on constructing brain higher function: in vivo brain imaging study on Pax6 mutant rats

    HIRAOKA KOTARO, OSUMI Noriko, SUMIYOSHI Akira, KAWASHIMA Ryuta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2013/04/01 - 2015/03/31

    More details Close

    Pax6 is a transcription factor which is crucial for the development of the central nervous system. It is thought to be an upstream of gene networks involved in brain patterning, neural migration, and neural circuit formation. Patients with PAX6 mutation have been reported to have mental retardation, frotal lobe dysfunction, or autism occationally. In this study, we evaluated morphology of the brain in Pax6 mutant and wild type rats using small animal magnetic resonance imaging (MRI). We found decreased volumes of the isocortex, hippocampus, amygdala, thalamus, midbrain, and corpus callosum in Pax6 mutant rats compared to wild type rats. The results shed some light on the role of Pax6 on constructing brain higher function.

  10. Synchronization of brain acitivity during social interaction

    KAWASHIMA Ryuta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2013/04/01 - 2015/03/31

    More details Close

    The purpose of this study was to create a real time monitoring system for synchronization of the brain activity of the dorsomedial prefrontal cortex (DMPFC) while social communicative situations using newly developed ultra-small near infra-red spectroscopy. We measured synchronization of the DMPFC from a pair of subjects during discussion by a group of subjects and walking with group of subjects while listening to a rhythm. We found degree of synchronization was related to the quality of social interaction among subjects. The results indicate that our system enable us to determine evaluation of quality of communication and/or sympathy, at least, between a pair of subjects.

  11. 高齢者の適応的運動訓練と脳活動の関連の解明研究

    川島 隆太, MAGISTRO Daniele

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2012/04/01 - 2015/03/31

    More details Close

    認知訓練（ワーキングメモリ（WM）訓練）と有酸素運動の二重課題訓練がそれぞれ片方より、認知機能、脳形態などにより大きな影響を及ぼす、有酸素運動との同時訓練によりＷＭ訓練効果が促進されるとするとの仮説の検証を行い、ＷＭ訓練と有酸素運動の二重課題訓練の認知機能、脳形態へ及ぼす影響を明らかにすることが本研究の目的である。 93名の健康な高齢者(65-75歳)がこの研究を完遂した。これらの被験者はまず、認知テスト、質問紙、MRI撮像などに参加し、その後12週間の訓練期間に入った。その後再び認知テスト、質問紙、MRI撮像などに参加した。12週間の間、被験者は週3回,１回約１時間ほど、訓練に参加した。被験者は３群にWM訓練群、有酸素運動群、両方の同時訓練群(WM訓練＋有酸素運動群)わけられた。 結果は、遅延記憶、非言語性推論の検査はＷＭ訓練を含む２群>有酸素のみ、有酸素+WM>WMという傾向はなしというWM訓練がこれらの機能に効果があることを示唆する結果パタンであった。前頭葉機能検査では、ＷＭ訓練を含む２群>有酸素のみ訓練群、有酸素+WM訓練>WM訓練という仮説によく合致する結果が得られた。脳画像の異方性に関しては有酸素運動+WM訓練の群において他の２群に比べ上縦束Iと呼ばれる白質繊維の異方性が有意に上昇していた。脳画像の平均拡散脳に関しては、前頭前野,前部帯状回の各所、海馬、黒質など脳幹周辺の水の拡散性が有酸素運動+WM訓練の群において他の２群より減少していた。 このように、WM訓練+有酸素運動の二重訓練は、前頭葉機能や、関連する領域の神経構造に変化を及ぼした。また、WM訓練や有酸素運動の認知機能への効果も確認された。

  12. Post-traumatic stress reduction and improvement of mental and physical function by horticultural therapy intervention

    KOTOZAKI Yuka, KAWASHIMA Ryuta, TAKI Yasuyuki, TAKEUCHI Hikaru, SEKIGUCHI Atsushi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2012/04/01 - 2014/03/31

    More details Close

    The purpose of this study was to reveal reduction of post-traumatic stress disorder (PTSD) and improvement of mental and physical function of residents who living the disaster area by horticultural therapy intervention. We carried out two intervention study; (a) the intervention of 54 women who lining the disaster area and (b) the intervention of 39 elderly women who lining the disaster area. As a result, in the intervention study of 54 women, the intervention group was increased the gray matter volume of the left subgenual anterior cingulate cortex and inferior frontal gyrus, Additionally, the intervention group was significantly improved CAPS score, PANAS PA score, PTGI-J score, and stress markers (cortisol and amylase). In the intervention study of 39 elderly women, the intervention group was improved depression symptom, QOL, and stress marker (cortisol).

  13. Development for decoding sysytem of attractiveness

    KAWASHIMA RYUTA, ARAKI Tsuyoshi, NOZAWA Takayuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2011/04/01 - 2014/03/31

    More details Close

    The purpose of this study was to decode individual feeling of attractiveness from brain imaging data under daily life situation. Firstly, we measured brain activity while watching pictures of animals and objects, and found an area in the medial frontal cortex was specifically related to attractive pictures. Then, we measured activity of the frontal cortex during the same task by multi-channel near infrared spectroscopy (NIRs), and found feeling of attractiveness could be decoded by machine learning on a channel located to the center of forehead. Finally, we measured brain activity by a ultra-small wearable NIRs under daily living situation, and found brain activity increased when a subject felt attractiveness during communication with other people.

  14. Neurofeedback training for user adaptation to motor-imagery based BCI

    KANOH Shin'ichiro, KAWASHIMA Ryuta, YOSHINOBU Tatsuo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku Institute of Technology

    2011 - 2013

    More details Close

    The BCI (brain-computer interface) based on motor imagery is to detect the intension of subjects from their brain activities from sensorimotor cortex during imagining to move their own limbs. This study aimed to investigate the methodology to use neurofeedback training (NF), on which the processed EEG or NIRS (brain blood flow measured by near-infrared spectroscopy) data is presented to subject in real time, for improving the applicability and accuracy on motor-imagery based BCI. It was found that the motor related EEG on mu, beta and gamma band could be extracted by applying local and sparse spatial filters designed by ICA (independent component analysis) to measured EEG data, and such components could be used for neurofeedback training to improve the performance of motor-imagery based BCI.

  15. Beneficial Effects on Cognitive Functions of Elders by Cognitive and/or Physical Intervention using Entertainments

    KAWASHIMA Ryuta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2011 - 2012

    More details Close

    The purpose of this study was to research and develop entertainments which can affect cognitive functions of elders. We performed three intervention studies using a randomized controlled trial design. We tested a personal videogame play, a group activity using mental stimulation, and a group activity using physical stimulation as intervention methods, and found all of them improved cognitive functions, e.g. executive function and processing speeds. We also found, by another experiment, that BDNF's polymorphisms affects effects of cognitive training.

  16. How we predict/complement linguistic information in brain?

    TAKAHASHI Kei, YOKOYAMA Satoru, YOSHIMOTO Kei, KAWASHIMA Ryuta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2010 - 2012

    More details Close

    During comprehending sentence, even if required linguistic information is lacked in a sentence, we can understand the sentence. Previous studies have already pointed out that we have cognitive function to predict or supply the lacked information, however unfortunately, its neural mechanism was still unknown. Therefore, the current study aimed to reveal how our brain predict or supply linguistic information by measuring cortical activation. The result showed increased activation in language-related regions such as so-called Broca's area and so on. This suggests that our brain rapidly starts syntactic and lexico-semantic processes in terms of already constructed sentence construction.

  17. ディスレキシアの言語トレーニングに関する行動科学及び神経科学的研究

    川島 隆太, MAIONCHI-PINO Norbert AlainRomuald, MAIONCHI-PINO Norbert Alain Romuald

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2010 - 2012

    More details Close

    本研究課題の目的は、日本語-フランス語間の対照言語学的実験研究を通して、両言語を母語とする読み書き障害を持つ子供に対するウェブベースの改善プログラムを構築することである。 上記の目的を達成するために、23年度は健常な日本語母語話者とフランス語母語話者の小児(8～12歳)を対象として音声の聞き分け実験を行なった。被験者は日仏合計で350名以上であった。なお、実験に際しては東北大学医学研究科の倫理委員会で承認済みである。 その結果、音節の区切りに関して日本語母語話者、フランス語母語話者に共通した音韻処理方策、言語ごとの音韻理解上での制約を見いだし、心理実験の結果、その制約が階層性をなしていることが分かった。現在本結果を22年度に行なった成人を対象とした実験結果と照らし合わせ、発達と音韻処理の関係について考察中である。なお、本結果は先行研究の結果とも矛盾しないものであった。成果発表として、国際学会で発表を行なった。 現在は本実験結果を元に脳波・脳磁図実験の準備中である。本実験は、音韻特性の階層性を脳内神経レベルで検査するものである。具体的には、ベースラインとなる音と、音韻素性を操作した音2種類を用意し、被験者に受動的に聞かせ、異なる音韻素性を処理した際に無意識にどのように脳内で反応が起こるかを調べる。同実験は始めに健常成人を対象に行なう。読み書き障害を持つ児童はこの聞き分けがうまく出来ないことが言語障害と関連していると仮定しており、同障害を持つ児童についても検査を行なう予定である。なお、実験刺激、プロトコルは心理実験で用いたものと同一にする予定である(倫理委員会で承認済み)。

  18. Neural bases underlying common psychological characteristics across psychosomatic diseases

    SEKIGUCHI Atsushi, KAWASHIMA Ryuta, SUGIURA Motoaki, KOTOZAKI Yuka, FUKUDO Shin, MORISHITA Joe, AIZAWA Emiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2010 - 2011

    More details Close

    We investigated neural bases underlying common psychological characteristics among psychosomatic diseases, such as stress vulnerability and somatization, by using neuroimaging methods. The results suggested that neural correlates of stress vulnerability is related to dysfunction of the dorsolateral prefrontal cortex and the ventral anterior cingulate cortex, and those of somatization is related to altered activation patterns in the anterior insula and the somatosensory area. The results support the effectiveness of psychological intervention to the patients with any types of psychosomatic diseases.

  19. Human Factor Study for Nuclear Power Plant Operator based on the Nero-Science

    TAKAHASHI Makoto, KAWASHIMA Ryuta, MIURA Naoki, MATSUYAMA Shigeo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2009 - 2011

    More details Close

    The experimental study was been performed to measure brain activity of nuclear power plant operator during operation. -Preliminary experiment has been performed at the experimental accelerator facility to confirm that the NIRS device can be utilized during the actual operation. -Brain activity of four real nuclear power plant operators was successfully measured using Ultra-small NIRS device.

  20. Practical approach to self-constructive learning on subjects on computer science

    MARUOKA Akira, KAWASHIMA Ryuta, MURAMOTO Toshiaki, TAKIMOTO Eiji, AMANO Kazuyuki, HARAGUCHI Kazuya

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Ishinomaki Senshu University

    2008 - 2010

    More details Close

    Among results we obtained in this project there exists a framework that yields instances of certain combinatorial puzzles. To explore such a framework, we focus on certain types of puzzles that ask an assignment of numbers to cells of nxn grids so that it satisfies certain constraints as well as the Latin square condition, that is, each row and column contains all of the numbers in {1, 2,…,n} Our algorithm based on the framework yields automatically puzzle instances whose difficulties to solve can be adjusted by means of puzzle inference rules built into the algorithm. We performed experiments to demonstrate that, as is expected, human solvers tend to solve puzzle instances correctly that are produced with easy inference rules, whereas they tend to fail to solve those produced with sophisticated rules.

  21. Development of EEG-based brain-computer interfaces with user adaptation capabilities

    KANOH Shin'ichiro, YOSHINOBU Tatsuo, KAWASHIMA Ryuta, HOSHIMIYA Nozumu, HANDA Yasunobu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2007 - 2009

    More details Close

    The methods to improve user-applicability of BCI (brain-computer interface) using non-invasive measurements of brain activity were proposed and investigated. The methodologies of feature extraction, pattern classification and online neurofeedback were studied by EEG, NIRS (near-infrared spectroscopy) and fMRI measurements. And the BCIs based on event-related potentials (ERPs) with higher usability were proposed and evaluated.

  22. 非侵襲的脳機能イメージングによるストレス・疲労の自己定量化システムの開発

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    Institution: 東北大学

    2007 - 2008

    More details Close

    疲労やストレスによるパフォーマンスの低下が、脳のどの領域の働きの変化と関連するのかを、非侵襲的脳機能イメージング手法を用いた基礎研究によって明らかにし、さらに、認知心理学的研究を追加することによって、健常成人の疲労やストレスによる認知機能の変化を定量的に評価可能なシステムを開発することが本研究の目指す最終的な目的である。 平成20年度は、機能的NIRsを用いて、健康な右利き大学生6名を対象として、連続単純計算による精神疲労負荷時の前頭前野活動を計測したが、疲労に伴う変化を計測できなかった。このため、精神疲労モデルを再構築することが必要であると判断し、心理学研究を展開した。健康な右利き大学生30名を対象として、内田クレペリンテスト(連続単純計算)による精神疲労の状態を、認知心理学的手法によって経時的に観察した。その際に、バランス栄養流動食を摂った場合と、水のみ摂取した場合の2条件を設定した。水のみ摂取した場合には、VAS法による精神疲労の内観が時間と共に増加し、単純計算の作業量も減少する傾向にあったが、流動食を摂った場合には、開始後1時間半までは、精神疲労の内観も単純計算の作業量も減少しないこと、1時間半以降は、水のみ摂取群と同様に精神疲労度の内観も、作業量も低下することがわかった。先行研究では、ブドウ糖のみ摂取した場合には、水のみ摂取と同じ疲労傾向を示すこともわかっており、朝食の摂取パターンによって、精神疲労とそれに伴うパフォーマンスの低下の程度に差が出ることがわかった。

  23. 脳科学的アプローチよる第二言語産出の研究

    川島 隆太, JEONG H., JEONG. H.

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2007 - 2008

    More details Close

    本研究では、第二言語を産出する際に関わる神経モジュールを特定するために、英語を第二言語として習得している日本語母語者話者30名を対象とし、脳機能画像法(fMRI)を用いて、第二言語産出時の脳活動を測定する二つの実験を行った。一つ目の実験では、英語を用いて対人コミュニケーションを行う際(リアル・コミュニケーション条件)の脳活動と、すでに作られている動画に向かって話かける際(動画コミュニケーション条件)の脳活動を比較した。二つ目の実験では、状況を単に記述する言語産出タスクと場面や相手に応じて言語産出するタスクを遂行する際の脳活動を測定し、比較した。両の実験では、コントロールタスクとして母語を用いて同様のタスクを実施した。分析結果、第二言語の言語産出は、母語よりもブローカ野を中心とする運動性言語領域、音韻作動記憶を担う前頭野と頭頂葉が有意に活動していること、さらに、使用場面やタスクの種類によって関連する神経基盤が異なることが分かった。特に、リアル・コミュニケーション条件と場面や相手に応じて言語を産出するタスクは、それぞれの比較タスクよりも、社会認知に関与する領域(両側の上側頭溝後部、内側前頭皮質)で有意な脳活動が測定された。これらの結果から、(1)第二言語を産出する際に関与する神経基盤は、言語産出領域だけではなく、社会性の認知に関わる神経モジュール(前頭前野の内側部や側頭回の前部など)が関与していること、(2)使用場面やタスクの種類などの要因が第二言語産出時の脳活動に影響を及ぼすことが示唆された。

  24. Advancement of Interface Technology based on Neuro-Science

    TAKAHASHI Makoto, KAWASHIMA Ryuta, SUGIURA Motoaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2006 - 2008

  25. 文字を「書く」ことの活動に関する科学的・実証的研究

    川島 隆太, 久米 公, 生田 菜穂, 浜本 純逸, 大内 善一, 鈴木 慶子, 林 朋美, 川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    2005 - 2006

    More details Close

    1.報告書(冊子体)の発行 H19.3に、下記の章立ての研究成果報告書(A4版、全87頁)を発行した。 序(川島) §1 硬筆による手書き活動時の脳活動に関する報告(鈴木・林・生田) §2 毛筆による手書き活動時の脳活動に関する報告(久米・鈴木・生田) §3 書字習慣に関する報告 ∫1 「メモをとると話しがよく理解できるか」に関する実験(鈴木・林・浜本) ∫2 「ノートとメモに関するアンケート」調査 §4 書字習慣と教科教育 ∫1 手書きメモと脳の活性化(浜本) ∫2 「手書き」を再定義する(鈴木) 「あとがき」にかえて(久米) 2. 成果 1)小学生を対象にして、硬筆を使用した5つ(視写1、視写2、聴写、暗写、単純計算)の書字活動の、脳活動をNIRSにより測定した。その結果、4つの文字を書く活動は、単純計算よりも、脳を活性化することがわかった。 2)中学生では、話しを聞くとき、メモを取る者と、メモを取らない者に分かれた。 別途、行ったアンケートやテストの結果から、メモを取る者には、下記のような特徴が見られた。 (1)自発的にノートを取る者が多い。 (2)国語テスト得点が中位の者が多い。 (3)備忘メモを必ず取る者が多い。 (4)情報メモを必ず取る者が多く、ときどき取るじゃが少ない。 (5)ひらめきメモをまったく取らない者が少ない。 (6)手で文字を書くことが嫌いな者が少ない。 3)アンケートの結果、手で字を書くことが好きな者は、情報メモ及びひらめきメモを取る傾向がある。 以上から、書字活動と知的創造的活動とは関連していることが予測できるので、今後は、その方向で研究を進めていきたい。

  26. 人間の高次脳機能を育む手書き活動に関する調査研究

    鈴木 慶子, 久米 公, 浜本 純逸, 大内 善一, 川島 隆太, 生田 奈穂

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 長崎大学

    2005 - 2005

    More details Close

    本調査研究は、文字を手書きする活動と脳の活性化との関係について調査し、文字を手書きする活動の、教育の場における価値を科学的に評価しようとすることを目的とした。 そのために、2つの生活介入調査(4週間)と一つの書字習慣調査(1〜2週間)を行い、下記のような構成の報告書を編集発行した(H18.3.31発行予定)。 序 (鈴木) §1 ニュースの聞き取り調査に関する報告 (鈴木・林・生田) §2 朗読の聞き取り調査に関する報告 (鈴木・林・生田) §3 「手書き指数」算出のための基礎調査に関する報告 (鈴木・林) §4 本調査研究の価値と展望 ∫1 国語教育における価値と展望 (浜本) ∫2 書写教育における価値と展望 (久米) ∫3 脳科学における価値と展望 (川島) 研究組織 結果としては、今回の調査では介入期間が短く、また被験者数が統計的に不十分であったために、文字を手書きする活動がそれ以外の認知機能を向上させるという点については認められなかった。しかしながら、いくつかの点で、私たちの仮説の正当性を裏付けるデータが出ている。 書字を用いた生活介入を大学生などを対象にして長期間続けることは、本調査研究の規模では不可能であるため、将来は、横断的なコホート研究を行うべきであろう。 その基盤として、書字の習慣を指数化する方法である「手書き指数」を開発していくことが有効であると考える。

  27. 相補的複合脳機能イメージングによる論理的思考活動の研究

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究

    Institution: 東北大学

    2005 - 2005

    More details Close

    本研究の目的は、「論理的思考力」を司る脳の巨視的回路網活動の時空間パターンを、機能的MRIによるBOLD情報と脳電図による脳電位情報を数学的に融合する最先端手法を用いて定量的に評価することである。 健常右利きの若年ボランティア10名を東北大学の大学生及び大学院生から募集した。ヘルシンキ宣言に則り、各被験者には、実験の目的・安全性について口頭及び書面により説明したのちに書面による同意書を得た。論理的思考力を評価する認知心理課題は、トポロジーテストを用いた。トポロジーテストは、心理学的に論理的思考力、特に推論の能力を評価するために開発されたものである。 トポロジーテスト遂行中の脳活動を、事象関連法を用いて、1.5T機能的MRIおよび64チャンネル脳電図計によって計測した。機能的MRIによる計測によって、トポロジーテスト遂行には、左右半球の背外側前頭前野、運動前野、頭頂連合野、下側頭回、外側後頭葉を含む広範なネットワークが活動することがわかった。多チャンネル脳波計によるシータ波の電源推定では、左右半球の背外側前頭前野、運動前野に電源が推定された。シータ波は内的思考活動と関係があることが知られており、機能的MRIの実験結果と一致する。 さらに、DTIを用いた領域間の神経線維の結合性の解析によって、外側前頭前野の領域は、同側半球の頭頂間溝領域、運動前野との連結が強いこと、運動前野の領域は、対側の運動前野、左半球の頭頂間溝領域との連結が強いことが示唆された。運動前野と頭頂間溝領域との連結は非対称的であった。トポロジーテストを用いた推論を行っている時には、主に左半球の頭頂間溝領域、左右両側半球の前頭前野と運動前野を結ぶネットワークが使われていたと考えられる。

  28. 機能的MRI及び近赤外線計測による感情の脳内表象の研究

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究

    Institution: 東北大学

    2003 - 2003

    More details Close

    認知・記憶・感情などに伴う脳活動を局所脳血流量を指標として画像化できる機能的MRI装置と、局所酸化ヘモグロビン量・局所還元ヘモグロビン量を指標として画像化できる近赤外計測装置を組み合わせて使用することにより、健常人の感情の表出に伴う脳活動の時空間パターン表現を明らかにし、感情を司る脳内メカニズムを考察することが研究の目的である。まず、右利き健常被験者60名(ヘルシンキ宣言にのっとり、被験者自身に実験の目的と安全性に関して口頭及び書面にて説明を行い、書面にて同意を確認)を対象として、機能的MRIを用いて、色の組み合わせの好き・嫌いを判断する課題を施行中の脳活動を計測した。この課題は被験者の感情を誘発する課題として作成した。課題では単なる色の組み合わせから、服装や化粧といった社会的な価値判断も伴うような色の組み合わせまで、数種類の異なったレベルの視覚刺激を用意する。課題は事象関連デザインとし、「好き」「嫌い」「どちらでもない」のそれぞれの判断をした時の脳活動を独立に解析した。それぞれの課題において、大脳右半球の外側前頭前野や基底核が「好き」の感情発現に、両側半球の側頭葉内側面は「嫌い」の感情発現に特異的な活性化を占めることが示唆された。この結果から、視覚刺激情報に対する「好き」「嫌い」の感情の発現には、異なった大脳皮質を含むネットワークの活動が関与することが示唆された。大脳右半球前頭前野の活動は、他の先行研究においても、視覚的に提示された写真に対する「好き」の判断との関係が示唆されており、ポジティブな感情発現との関連が強く示唆される。さらに、感情の表出に関する脳活動の時空間パターンを定量解析するために、機能的MRIによる脳活動の空間パターン情報と近赤外計測装置による脳活動の時間パターン情報を融合する数学モデルの作成を行った。

  29. 非侵襲的イメージング手法による脳機能の加齢変化の研究-相補的融合画像による時空間パターン解析-

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究(C)

    Institution: 東北大学

    2000 - 2000

    More details Close

    健常右利き若年男性5名を対象として、ポジトロンCT及び脳磁図による脳機能計測を行った。ポジトロンCTでは、さまざまな人の顔の写真をコンピュータにより提示し、それらの顔が既知の人のものか、未知の人のものかを弁別する課題遂行中の脳血流の変化を測定し、コントロール課題と比較した。脳磁図では、既知の顔、未知の顔の提示に関連した、脳磁界の変化を計測した。 ポジトロンCTデータは、被験者個人ごとに統計解析を行い、脳賦活地図を作成した。脳磁図データは、ポジトロンCTデータとの重ねあわせを行うために、2つの異なった方法による解析を試みた。まず、ポジトロンCTによる脳賦活地図を利用して、脳賦活の認められた領域内にのみ双極子を強制的に推定させた。ついで、被験者の脳表面にポジトロンCTデータと同程度の空間解像度をもつ機能単位を想定し、その上に脳磁図データを展開する、BET(Brain Emission Tomography)と呼ばれる手法を用いた。 ポジトロンCTデータより、顔の既知・未知の弁別には、外側後頭葉、側頭葉下面、側頭葉内側面、側頭極に脳賦活を認めた。脳賦活領域上に双極子を計算する方法では、側頭葉下面、外側後頭葉、側頭葉内側面に、それぞれ画像提示後160、180、200ミリ秒後に活動が計算できた。側頭極では計算が発散してしまい双極子は同定できなかった。BETでは、外側後頭葉と側頭極にそれぞれ画像提示後200、270ミリ秒後に脳賦活を認めた。 ポジトロンCT画像情報とBETの情報は、違いに独立なため、これらの画像情報の融合を数学的に行うことにより、脳活動の時空間パターンは検討可能と思われた。

  30. Development of Mind : Developmental Disorder

    KOJIMA Syouzo, NAGASAKI Tsutomu, TATSUMI Itaru, SUGISHITA Morihiro, KAWASHIMA Ryuta, YAMAMOTO Junichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research on Priority Areas (A)

    Institution: Kyoto University

    1997 - 2000

    More details Close

    In this project, we tried to introduce new behavioral and physiological techniques to the study of disabilities on cognition and language, especially developmental disabilities. One approach was the use of computers for the training of comprehension and reading of written letters and words in the home of autistic children or learning disabilities. The stimulus equivalence paradigm was used. Another approach was the introduction of scripts to analyze and to train the communication in children with down syndrome. In this study, the cognition of the intention of others in communication was examined. This is the precursor of the theory of mind. We introduced neuroimaging techniques to the studies of disabilities. Positron CT and functional MRI were used. It was reported that the human amygdala plays an important function for detecting gaze direction. This finding is related to a neuronal basis of autistic children. Functional MRI studies were conducted to find simple methods for determining the dominance hemisphere. A PET study revealed that the decrease in regional cerebral blood flow in the left temporal or frontal cortex during word finding in aged humans. These results may explain difficulty of retrieval of words in aged people. Aged monkeys showed difficulties in forming learning set and inhibit inadequate response tendencies. In addition, aged monkeys have difficulties in associating objects and reward and/or non-reward. These behavioral tendencies are common to both monkeys and humans, and suggest that the decline of the functions of the ventral parts of the frontal cortex.

  31. PETおよびfMRIによる高次体性感覚に対する主観的注意の機能解剖研究

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究(A)

    Institution: 東北大学

    1999 - 1999

    More details Close

    ヒトにおける視覚-体性感覚の異なったモダリティー間での情報の統合に関する処理機構を明らかにした。右利き若年男性健常被験者9名を対象とした。局所脳血流量をポジトロンCT装置を用いて計測した。課題は、視覚-視覚課題(VV)、体性感覚-体性感覚課題(SS)、視覚-体性感覚課題(VS)、体性感覚-視覚課題(SV)、を行わせた。被験者の右手の親指と人さし指に、仮想空間上で物体を触知できる反力装置の指サックを装着させた視覚刺激として直径の異なる円柱を作成した。また体性感覚刺激として、同じ円柱の前面にスクリーンを設置し円柱は把握可能だが直接は円柱は見えない刺激を作成した。 右前頭前野と左小脳後葉外側は、全ての課題で賦活される傾向にあった。これらの領域は、作動記憶やマッチングに関与すると考えられた。右背側運動前野は、VS課題に特異的に活動を示した。異なったモダリティー情報が交錯するマルチモダル領域である可能性を考えた。右腹側運動前野は、SS課題とVS課題でのみ活動を示した。知覚している体性感覚情報を、他の情報と比較することに関与すると考えられる。頭頂間溝領域前部は、SS・VS・SV課題で賦活した。この領域は体性感覚情報処理に関与していると考えられた。下側頭溝領域はVV課題とVS課題で賦活を示した。視覚情報の作動記憶に関与すると考えられた。 視覚と体性感覚のクロスモダルマッチングは、先にどちらの情報を作動記憶に貯えるかにより、2つの異なった経路により処理されることが示唆された。まず体性感覚情報を記憶しこれを視覚情報と比較する時には、それぞれのモダリティー情報を処理する領域の活動のみが必要で、情報はその領域間をもれ伝わるとの仮説、そして視覚情報を記憶しこれを体性感覚情報と比較するときには、モダリティー特異的な情報処理領域の他に、マルチモダル領域で情報処理が行われるとの仮説を示唆した。

  32. PETによる高次体性感覚機能に対する主観的注意の機能解剖研究

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究(A)

    Institution: 東北大学

    1998 - 1998

    More details Close

    視覚的に提示された物体を道具を用いて把握するときのヒトの脳活動を検討した。正常右利き若年男子8名を対象とした。全員書面による同意書に署名をした。実験では被験者の胸の上方に30cm四方のボードを設置した。このボード上には、右下の角からボードの下面に対して30度と60度をなす2種類の平行線が引かれている。被験者の右手に実験中常に火ばしを保持させた。被験者はポジトロンCT撮像中に次の4つの課題を行った。1)コントロール課題:被験者に火ばしを保持したまま運動を行わず、ボードの中央を見つめているよう指示した。2)ポイント課題:被験者に30度と60度の平行線領域を交互に右手の人さし指で触るよう指示した。3)把握課題:被験者に、30度と60度の平行線領域のどちらかに置かれた発砲スチロール製の円柱を右手の人さし指と親指で摘み、もう一方の領域内に交互に置くように指示した。4)道具課題:被験者に、30度と60度の平行線領域のどちらかに置かれた発砲スチロール製の円柱を右手に保持した火ばしで摘み、もう一方の領域内に置くように指示した。ポジトロンCT装置はと酸素15標識水を使用して局所脳血流画像を撮像した。各被験者の脳血流画像は各被験者の脳MRI画像をもとにして、流体画像変型システムを用いて解剖学的標準化を行い、その後、SPM96を用いて統計的に有意な血流増加を示した領野を同定した。コントロール課題と比較して、各運動課題では、左頭頂連合野・左一次運動感覚野・左被殻・右前頭前野・右上側頭回・帯状回などの領域の賦活が認められた。把握課題および道具課題では、これらの領域に加えて、左半球頭頂溝領域と後帯状回領域に有意な活動が認められた。この活動はポイント課題と比較しても有意であった。大脳右半球の頭頂間溝には道具課題遂行時にのみ有意な活動を示す領域が観察された。

  33. International Data Base for Human Brain Function

    FUKUDA Hiroshi, KINOMURA Shigeo, KAWASHIMA Ryuta, ZILLES Karl, ROLAND Per

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for international Scientific Research

    Institution: TOHOKU UNIVERSITY

    1997 - 1998

    More details Close

    1. Development and Evaluation of the Computerized Brain Atlas System We validated the anatomical precision of spatial normalization with the Elastic Transformation System which has developed by Zilles's group with our collaboration. We found that this system shows high effectiveness in spatial normalization procedure compared with other systems, indicating that it can be used not only for positorn emission tomography (PET) activation studies but for functional magnetic resonance imaging (MRI) studies. 2. Functional Brain Mapping of Cognitive and Motor Function Roland's group and our group participated this project. We used PET to investigate functional brain areas of humans involved in many kinds of cognitive or motor tasks. The results obtained are used as contents of the brain function database which has been developing by our group. 3. Development of International Brain Anatomy Database We and Evans's group had a meeting in Montreal, and have agreed to create comparable international brain anatomy database with Zilles's group. We have decided to correct 300 3D-brain MRI of healthy subjects for each group, and to perform inter-ethnic comparisons using spatial normalization technique develped by Evans's group. Our group already corrected 150 brain MRIs, and we have estimated standard brain anatomy of the Japanese population of different age group from this data.

  34. PETによる高次視覚機能に対する主観的注意の機能解剖研究

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 重点領域研究

    Institution: 東北大学

    1997 - 1997

    More details Close

    我々はさまざまな奥行き情報を統合して三次元的な形態や空間を認識していることが心理学的に証明されている。しかし、脳内でのこのような視覚情報処理機構に関してはほとんど解明されていない。そこで本研究では、ポジトロンCTを用いて、三次元的な視覚情報処理に関与して活動を示す巨視的な神経回路の特定を行った。正常右利き若年男子6名を対象とした。被験者はポジトロンCT撮像中に次の2つの形態の識別課題を行った。 1)三次元形態の識別課題(3D):被験者にコンピュータグラフィクスで作成した三次元図形(六角錐)を視覚刺激としてHMDを使って立体視させた。刺激は見た目は変わらないが凹凸の程度が違っていて、見本と同じ凹凸の刺激が提示された時に右手でボタンを押して合図をさせた。 2)面の傾き識別課題(3DS):被験者にコンピュータグラフィクスで作成した平面を視覚刺激としてHMDを使って立体視させた。被験者は面の三次元的な傾きに注目して、見本と同じ傾きの刺激が提示された時に右手でボタンを押して合図をさせた。それぞれのコントロール課題として、同じ視覚刺激セットをもちいて、見本刺激提示直前に提示される手掛かり刺激がでたときに右手でボタンを押して合図をさせた。3DS課題・3D課題ともに大脳右半球頭頂間溝皮質に有意な血流増加を認めた。左半球では有意な血流増加は認められなかった。 3DS課題で賦活された領域は、3D課題で賦活された領域よりも前方側に位置していた。本研究結果は、三次元構造認識のためのニューロン機構が頭頂間溝領域にあることを示した。さらに我々の最近の研究より、二次元の線分の角度の弁別を同様な遅延見本合わせ課題を行わせた場合でも、大脳右半球の頭頂間溝皮質に賦活が認められることが明らかにされており、右半球の視覚的な物体の立体的構造の情報処理における特異性の存在が示唆される。

  35. 認知発達の機構

    桐谷 滋, 川島 隆太, 杉下 守弘, 小嶋 祥三, 大津 由起雄, 波多野 誼余夫

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東京大学

    1996 - 1996

    More details Close

    次年度以降の重点領域研究「心の発達-認知的成長の機構」実施のために、対象研究領域(概念発達、言語発達、認知発達障害)の研究動向の展望と、必要研究課題の検討を行った。このためにシンポジウム、認知・言語の成立(平成8年10月、重点領域研究:認知言語の成立と共催)、認知発達研究における言語・文化間比較(平成9年1月)および研究会、脳機能計測の最近の話題(平成8年12月)を開催した。前記シンポジウムでは、知識の獲得と改定の発達過程(波多野)、文法知識の獲得課程(大津)、音声コミュニケーションの発達過程(桐谷)、動物と人の音声能力の比較(小嶋)についての研究課題の整理、提案がなされた。後者のシンポジウムでは、特に発達研究における言語・文化間比較による接近について議論され、人以外の霊長類における社会文化的現象(松沢)、言語の地域・社会差の現象(日比谷)、脳機能の言語間比較(川島)の研究の動向と可能性が検討された。脳機能計測の研究会では各種計測手法の現況と発達研究への応用可能性が検討され、又、特にPETを用いた画像および音声認知機能について実際に就験的実験を行い、今後の実験に関する具体的指針を得た。 以上を通じ概念発達については素朴理論を中心に領域固有性および制約の要因を重視して研究をすすめること、言語発達については普遍文法と経験の相互作用について研究をすすめること、認知発達障害については脳機能計測を中心にすすめることの指針を得た。

  36. PETによる高次視覚機能に対する主観的注意の機能解剖研究

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 重点領域研究

    Institution: 東北大学

    1996 - 1996

    More details Close

    視覚対象の認知およびそれに対する主観的注意に関連して活動を示すとヒト脳の巨視的神経回路を明らかにすることが本研究の目的である。 右利き若年者正常男性7名を対象とし、局所脳血流量をポジトロンCT装置を用いて計測した。課題遂行中は画面中央に表示した固視点を常に見つめているように被験者に指示をした。まずサンプル刺激として白黒のWalshパターンを固視点の両側に固視点から12.5度離れた位置に250msec呈示した。1000から4000secの遅延期間後、テスト刺激として白青のパターンを同じ位置に250msec呈示し、500から1500msecのインターバル後同じシークエンスを繰り返した。右注意課題では右視野に呈示されたサンプル刺激とテスト刺激が同一のパターンであれば右手のボタンを押して合図をするように指示をした。左注意課題では左視野に呈示されたパターンで同じことを行わせた。コントロール課題ではサンプル課題2回呈示につき一回ボタンを押すように指示をした。PET画像より局所脳血流画像を計算し、コンピュータ化脳図譜システムを利用して局所脳血流画像を解剖学的に標準化したのち、各注意課題引くコントロール課題の差分画像を作製、有意な変化を同定した。 右注意課題では右半球前頭前野など17の領域に、左注意課題では左半球前頭前野など16の領域に有意な活動を認めた。左半球の下側頭溝内、右半球の頭頂間溝内に双方の課題で有意な活動を示す領域が認められた。 本研究では、どちらの半球の一次視覚野に入ったパターン刺激でも遅延見本課題を遂行するときに左半球の下側頭溝領野が視覚情報処理系として機能するという半球機能差の存在が明らかになった。また右半球の頭頂間溝皮質内の領域はposterior attentional systemとして、辺縁視野への注意機構に関連することが示唆された。

  37. ポジトロンCTを用いた短期記憶関連脳機能地図の作成

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 重点領域研究

    Institution: 東北大学

    1995 - 1995

    More details Close

    本年度の研究では、短期記憶をコントロールする“central executive"機能が脳のどこかの領野にあるのを明らかにした。 9名の右利き男性被験者を対象とし、局所脳血流量をPET装置および酸素15で標識した水を用いて測定した。被験者はPETによる計測の最中に次の2つ課題を行った。1)角度DMS課題:被験者に頭部固定型ディスプレー(HMD)を装着させた。円の次に呈示される線分の角度を記憶し、同じ角度の線分が呈示された場合に右手で合図するよう指示した。2)コントロール課題:角度DMS課題と同じ視覚刺激を用いた。被験者には円が呈示されたときに右手で合図をするように指示した。 各被験者の脳血流画像は、コンピュータ化脳図譜システムを利用して、解剖学的標準化した。その後、角度DMS課題引くコントロール課題の差分画像を作成し、有意(p<0.001)に活動を示した領野を特定した。 角度DMS課題で活動を示した領野は、左半球の捕捉運動野、Precuneus、島皮質、下部後頭葉と、右半球の頭頂間溝、前頭前野に3ケ所、後頭葉に2ケ所、中側頭回に認められた。 右半球前頭前野は他のモダリティーを使った短期記憶課題でも賦活されることが昨年度の研究で明らかにされており、この領野はmulti-modal areaであり、短期記憶に関するcentral executive機能又はcontrol機能を持つ領野である可能性が示唆された。

  38. ポジトロンCTによる運動課題遂行中のヒト脳機能地図の作成

    川島 隆太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 奨励研究(A)

    Institution: 東北大学

    1994 - 1994

    More details Close

    上肢の運動に関連して働く、ヒト脳の巨視的な神経回路の解明を行うことが本研究の目的である。2組各10名の正常右利き男性被験者を対象とした。10名の被験者は自発的指運動および自発的上腕運動施行中に、他の10名の被験者は光刺激に基づく指運動施行中に局所脳血流量を測定した。自発的運動課題では、被験者は1秒に約1回、右手親指と人さし指を付ける運動、または上腕の筋肉を動かす運動を行った。光刺激に基づく運動では、被験者はまず、被験者の目の前に置かれた1個の発光ダイオードが赤く光ったら右手親指を、それが緑に光ったら人さし指を曲げる運動を行った。次に、赤く光ったなら同じように親指を曲げるが、緑なら何もしない運動を行わせた。いずれもコントロール課題は開眼安静状態であった。局所脳血流量はポジトロンCT装置を用いて測定した。脳血流画像はコンピュータ化脳図譜システムにて、3次元的に標準脳の形に変換後、各課題引くコントロールの差分画像を作成した。各組の各課題ごとに統計学的に有意に活動を示した領野を特定した。右指と右上腕の運動を支配する領野が左半球一次運動野の中にそれぞれ2ケ所ずつ存在すること、右腕の自発運動には運動の部位には関わりなく左半球の補足運動野と頭頂連合野の活動が重要であること、光刺激の意味を判断し適切な右手で運動を発現させるためには左半球の帯状回の活動が重要であること、運動を発現させないという意志発動は右半球の前頭前野が重要であること、が世界で初めて明らかにされた。

  39. ポジトロンCTを用いた短期記憶関脳機能地図の作成

    川島 降太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 重点領域研究

    Institution: 東北大学

    1994 - 1994

    More details Close

    短期記憶の情報処理に関する、ヒト脳における巨視的な神経回路の解明を行うことが本研究の目的である。2組各10名の右利き男性被験者を対象とした。10名の被験者は"短期記憶関連なし課題"施行中に、他の10名の被験者は"短期記憶関連あり課題"施行中に局所脳血流量を測定した。被験者は、両眼で単色光を凝視し、両耳より単音を聴取し、左手の人差し指の指先で振動を同時に触知することが求められた。記憶関連なし課題では、3種類の感覚刺激の中で1種類の刺激の強度(視覚:明るさ、聴覚:周波数、触覚:振動数)を連続的に変化させた。被験者には、感覚刺激の強さが強く変化したときは何もせず、弱く変化したときは右手のボタンを押すよう指示した。記憶関連あり課題では、感覚刺激を連続的に変化させるのではなく、あいだに一定の低いレベルの刺激を与えた。被験者は感覚刺激の強さの弁別を行うために、この低いレベルの刺激が与えられている間に、前回の感覚刺激の強さを記憶していなくてはならない。 局所脳血流量はポジトロンCT装置を用いて測定した。脳血流画像はコンピュータ化脳図譜システムにて、3次元的に標準脳の形に変換後、各課題引くコントロールの差分画像を作成した。各組の各感覚刺激課題ごとに統計学的に有意に活動を示した領野を特定した。短期記憶関連あり課題施行中に共通して活動を示した領野の中で、右半球の中前頭回の2つの領野は、短期記憶なし課題施行中には活動を示さなかった。2つの課題はそれぞれ、感覚入力、知覚、感覚情報の弁別運動出力に関しては、同一であり、唯一の違いは短期記憶の保持が課題遂行に必要か否かである。したがってこの2つの右半球の領野の活動は、感覚モダリティーによらない、短期記憶の保持に重要な関連があることが世界で始めて示唆された。

Show all Show first 5

Other 5

  1. 高齢者と学習障害の脳機能改善コホート研究

    More details Close

    高齢者と学習障害の脳機能改善コホート研究

  2. コミュニケーション機能の発達における「身体性」の役割

    More details Close

    コミュニケーション機能の発達における「身体性」の役割

  3. 脳機能イメージング

    More details Close

    脳機能イメージング

  4. 脳機能イメージングほか

    More details Close

    脳機能イメージングほか

  5. 知財創造経費

    More details Close

    知財創造経費