研究者詳細

顔写真

セキ エツ
石 悦
Yue Shi
所属
大学院薬学研究科 分子薬科学専攻 分子解析学講座(医薬資源化学分野)
職名
特任助教(研究)
学位
  • 博士(薬科学)(東北大学)

  • M.S.(山東大学)

e-Rad 研究者番号
61003017

研究分野 1

  • ライフサイエンス / 薬系化学、創薬科学 / 天然物生合成

論文 5

  1. Genome Mining-Based Discovery of Pyrano[2,3-c]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups. 国際誌 査読有り

    Yue Shi, Taro Ozaki, Yohei Morishita, Tohru Taniguchi, Hiroyasu Sato, Yoshitaka Aoyama, Akihiro Sugawara, Kaho Numata, Tomoya Fuse, Ryo Matsuda, Kento Hosotani, Hanako Fukano, Yoshihiko Hoshino, Aki Hirabayashi, Masato Suzuki, Jiro Yasuda, Rokusuke Yoshikawa, Hironori Hayashi, Eiichi N Kodama, Yoshitaka Shimotai, Hiroshi Hamamoto, Rohan A Davis, Teigo Asai

    Organic letters 27 (31) 8580-8585 2025年8月8日

    DOI: 10.1021/acs.orglett.5c02504  

    詳細を見る 詳細を閉じる

    Genome mining of polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) in fungal endophyte Neopestalotiopsis olumideae strain BRIP 39872 identified seven new natural products (olumilides A-D, D1, D1', D2) with pyrano[2,3-c]pyrrole scaffolds and their biosynthetic precursor preolumilide. Unlike known congeners, such as curvupallides, olumilides possess alkyl side chains with branched methyl groups and threonine-derived core scaffolds. Absolute configurations were determined by microED and ECD simulations, providing valuable information for further research focusing on the stereochemistry of PKS-NRPS reactions.

  2. A new 3,6-dialkyl-α-pyrone produced by the heterologous expression of a PKS-NRPS hybrid enzyme derived from a Pestalotiopsis endophyte 査読有り

    Yue Shi, Taro Ozaki, Akihiro Sugawara, Yohei Morishita, Yu Pei Tan, Roger G. Shivas, Rohan A. Davis, Teigo Asai

    Tetrahedron Letters 134 154865-154865 2024年1月

    出版者・発行元: Elsevier BV

    DOI: 10.1016/j.tetlet.2023.154865  

    ISSN:0040-4039

  3. Electrospun composite nanofibers with all-trans retinoic acid and MWCNTs-OH against cancer stem cells 査読有り

    Haijun Chen, Yue Shi, Lei Sun, Shilei Ni

    Life Sciences 258 118152-118152 2020年10月

    出版者・発行元: Elsevier BV

    DOI: 10.1016/j.lfs.2020.118152  

    ISSN:0024-3205

  4. The effect of polysaccharides from Cibotium barometz on enhancing temozolomide–induced glutathione exhausted in human glioblastoma U87 cells, as revealed by 1H NMR metabolomics analysis 査読有り

    Yue Shi, Xiao Wang, Ning Wang, Fei-Fei Li, Yu-Lin You, Shu-Qi Wang

    International Journal of Biological Macromolecules 156 471-484 2020年8月

    出版者・発行元: Elsevier BV

    DOI: 10.1016/j.ijbiomac.2020.03.243  

    ISSN:0141-8130

  5. A screening method based on 1D CSSF-TOCSY for the identification and quantification of 11 illegal adulterants in herbal medicines 査読有り

    Fei-Fei Li, Chang-Chuan Guo, Yan-Li Zhang, Ning Wang, Yue Shi, Shu-Qi Wang

    Microchemical Journal 153 104495-104495 2020年3月

    出版者・発行元: Elsevier BV

    DOI: 10.1016/j.microc.2019.104495  

    ISSN:0026-265X

共同研究・競争的資金等の研究課題 1

  1. 未知ドメインを持つ非典型的なNRPSの機能解析における天然物探索研究

    石 悦

    2026年4月 ~ 2028年3月