Details of the Researcher

PHOTO

Yue Shi
Section
Graduate School of Pharmaceutical Sciences
Job title
Specially Appointed Assistant Professor(Research)
e-Rad No.
61003017

Research Areas 1

  • Life sciences / Pharmaceuticals - chemistry and drug development /

Papers 5

  1. Genome Mining-Based Discovery of Pyrano[2,3-c]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups. International-journal Peer-reviewed

    Yue Shi, Taro Ozaki, Yohei Morishita, Tohru Taniguchi, Hiroyasu Sato, Yoshitaka Aoyama, Akihiro Sugawara, Kaho Numata, Tomoya Fuse, Ryo Matsuda, Kento Hosotani, Hanako Fukano, Yoshihiko Hoshino, Aki Hirabayashi, Masato Suzuki, Jiro Yasuda, Rokusuke Yoshikawa, Hironori Hayashi, Eiichi N Kodama, Yoshitaka Shimotai, Hiroshi Hamamoto, Rohan A Davis, Teigo Asai

    Organic letters 27 (31) 8580-8585 2025/08/08

    DOI: 10.1021/acs.orglett.5c02504  

    More details Close

    Genome mining of polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) in fungal endophyte Neopestalotiopsis olumideae strain BRIP 39872 identified seven new natural products (olumilides A-D, D1, D1', D2) with pyrano[2,3-c]pyrrole scaffolds and their biosynthetic precursor preolumilide. Unlike known congeners, such as curvupallides, olumilides possess alkyl side chains with branched methyl groups and threonine-derived core scaffolds. Absolute configurations were determined by microED and ECD simulations, providing valuable information for further research focusing on the stereochemistry of PKS-NRPS reactions.

  2. A new 3,6-dialkyl-α-pyrone produced by the heterologous expression of a PKS-NRPS hybrid enzyme derived from a Pestalotiopsis endophyte Peer-reviewed

    Yue Shi, Taro Ozaki, Akihiro Sugawara, Yohei Morishita, Yu Pei Tan, Roger G. Shivas, Rohan A. Davis, Teigo Asai

    Tetrahedron Letters 134 154865-154865 2024/01

    Publisher: Elsevier BV

    DOI: 10.1016/j.tetlet.2023.154865  

    ISSN: 0040-4039

  3. Electrospun composite nanofibers with all-trans retinoic acid and MWCNTs-OH against cancer stem cells Peer-reviewed

    Haijun Chen, Yue Shi, Lei Sun, Shilei Ni

    Life Sciences 258 118152-118152 2020/10

    Publisher: Elsevier BV

    DOI: 10.1016/j.lfs.2020.118152  

    ISSN: 0024-3205

  4. The effect of polysaccharides from Cibotium barometz on enhancing temozolomide–induced glutathione exhausted in human glioblastoma U87 cells, as revealed by 1H NMR metabolomics analysis Peer-reviewed

    Yue Shi, Xiao Wang, Ning Wang, Fei-Fei Li, Yu-Lin You, Shu-Qi Wang

    International Journal of Biological Macromolecules 156 471-484 2020/08

    Publisher: Elsevier BV

    DOI: 10.1016/j.ijbiomac.2020.03.243  

    ISSN: 0141-8130

  5. A screening method based on 1D CSSF-TOCSY for the identification and quantification of 11 illegal adulterants in herbal medicines Peer-reviewed

    Fei-Fei Li, Chang-Chuan Guo, Yan-Li Zhang, Ning Wang, Yue Shi, Shu-Qi Wang

    Microchemical Journal 153 104495-104495 2020/03

    Publisher: Elsevier BV

    DOI: 10.1016/j.microc.2019.104495  

    ISSN: 0026-265X

Research Projects 1

  1. 未知ドメインを持つ非典型的なNRPSの機能解析における天然物探索研究

    石 悦

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2026/04 - 2028/03