東北大学研究者紹介

研究者詳細

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日本語 English

顔写真

オバラ　タク

小原　拓

Taku Obara

所属

東北メディカル・メガバンク機構　予防医学・疫学部門

職名

准教授

学位

博士（医療薬学）（東北大学）
修士（薬学）（東北大学）

researchmap

https://researchmap.jp/0812_takuobara

J-GLOBAL ID

200901082658718805

研究キーワード 3

薬剤疫学
臨床薬学
疫学

研究分野 2

ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない /
ライフサイエンス / 医療薬学 /

論文 568

Sex difference of genetic risk in the prevalence of atrial fibrillation. 国際誌

Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

Heart rhythm　2025年3月23日

DOI： 10.1016/j.hrthm.2025.03.1974 　

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BACKGROUND: Early detection and management of atrial fibrillation (AF) are crucial. Combined models incorporating genetic risks and clinical risks have been developed to improve predictive ability. Although sex differences have been reported in many aspects of AF, sex differences in genetic risk have not been studied. OBJECTIVE: To assess the sex difference in the effect of AF-PRS on AF prevalence using cross-sectional data from the Tohoku Medical Megabank Project Community-Based Cohort Study in Japan. METHODS: Polygenic risk score for AF (AF-PRS) and Cohorts for Heart and Aging Research in Genomic Epidemiology AF (CHARGE-AF) score were used for genetic AF risks and clinical AF risks, respectively. Sex differences in the association of AF-PRS with the prevalence of AF were evaluated. RESULTS: Among 16,853 participants (mean age, 63.4 years and 30.7% men), the prevalence of AF was 4.9% in men and 1.1% in women. In the group with high AF-PRS and high CHARGE-AF score, the odds ratio for AF was highest in men and women (8.2 in men and 9.4 in women), compared to that in the group with low AF-PRS and low CHARGE-AF score. Integrating AF-PRS into the CHARGE-AF score significantly enhanced the area under the curve of receiver operating characteristic for AF in men (from 0.639 to 0.749) but not in women (from 0.710 to 0.733). CONCLUSION: Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.
Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. 国際誌

Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Yuki Nagata, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Margaret A Taub, Pamela J Surkan, Shinichi Kuriyama, Takeo Fujiwara

Journal of human genetics　2025年3月21日

DOI： 10.1038/s10038-025-01330-4 　

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Gestational diabetes mellitus (GDM) is common in Japanese women, posing serious risks to mothers and offspring. This study investigated the influence of maternal genotypes on the risk of GDM and examined how these genotypes modify the effects of psychological and dietary factors during pregnancy. We analyzed data from 20,399 women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort. Utilizing two customized SNP arrays for the Japanese population (Affymetrix Axiom Japonica Array v2 and NEO), we performed a meta-analysis to combine the datasets. Gene-environment interactions were assessed by modeling interaction terms between genome-wide significant single nucleotide polymorphisms (SNPs) and psychological and dietary factors. Our analysis identified two SNP variants, rs7643571 (p = 9.14 × 10-9) and rs140353742 (p = 1.24 × 10-8), located in an intron of the MDFIC2 gene, as being associated with an increased risk of GDM. Additionally, although there were suggestive patterns for interactions between these SNPs and both dietary factors (e.g., carbohydrate and fruit intake) and psychological distress, none of the interaction terms remained significant after Bonferroni correction (p < 0.05/8). While nominal significance was observed in some models (e.g., psychological distress, p = 0.04), the data did not provide robust evidence of effect modification on GDM risk once adjusted for multiple comparisons. These findings reveal novel genetic associations with GDM in Japanese women and highlight the importance of gene-environment interactions in its etiology. Given that previous genome-wide association studies (GWAS) on GDM have primarily focused on Western populations, our study provides new insights by examining an Asian population using a population-specific array.
Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. 国際誌

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

Nutrition (Burbank, Los Angeles County, Calif.)　135　112739-112739　2025年3月8日

DOI： 10.1016/j.nut.2025.112739 　

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OBJECTIVES: Adiposity rebound (AR) corresponds to the start of the second rise in the body mass index curve during infant growth. Early AR (before age 5) confers increased risk of adiposity and metabolic disorders but is less likely to occur in breastfed infants. Although lipids in breast milk are important in child growth, information is limited regarding which lipids are involved in AR. The object of this study was to explore the association between breast milk lipids and AR status in children. METHODS: We designed a case-control study of 184 mother-child pairs (AR cases: n = 93; controls: n = 91) included from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Breast milk was collected 1 month postpartum and comprehensive lipid analysis was performed. Partial least square-discriminant analysis was used to explore candidate lipids, and multivariable logistic regression analysis was used to evaluate associations with the AR status of children. RESULTS: We detected 667 lipid molecules in 12 lipid classes in breast milk. Partial least square-discriminant analysis revealed the association of fatty acid-hydroxy fatty acid (FAHFA) and cholesterol ester (ChE) with AR status. Multivariable logistic regression analysis showed that in pairs with exclusive breastfeeding at 1 month postpartum, FAHFA (odds ratio 1.57 [95% confidence interval, 1.06-2.32]) was positively associated with early AR, and ChE (odds ratio 0.55 [95% confidence interval, 0.36-0.86]) was negatively associated. CONCLUSIONS: Breast milk lipids (FAHFA, ChE) associated with the AR status of children, indicating the potential to regulate a child's adiposity and possible metabolic disorders in adulthood.
Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case-Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Tomoko Tanaka, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

The Journal of nutrition　2025年3月7日

DOI： 10.1016/j.tjnut.2025.02.024 　

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BACKGROUND: Adiposity rebound (AR) is the point when the body mass index (BMI) begins to rise again during early childhood. Early AR (before age 5) is associated with a higher risk of lifelong obesity and metabolic disorders and may be influenced by breastfeeding. Although human milk oligosaccharides (HMOs) in breast milk are crucial for child growth, their association with AR status has not been studied. OBJECTIVE: To explore breast milk HMO compositions and molecules associated with AR status in children. METHODS: In this case-control study, we included 184 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study (93 AR cases, 91 controls). Breast milk was collected 1 month postpartum, and the concentration of 15 HMO molecules and alpha-diversity index (Inverse Simpson index) were quantified. Wilcoxon's rank-sum test and partial least squares-discriminant analysis (PLS-DA) identified candidate HMOs, and multivariable logistic regression analysis evaluated associations between candidate HMOs and AR status. Analyses were stratified by maternal secretor status (secretor or non-secretor). RESULTS: In secretor mothers, multivariable logistic regression showed that the Inverse Simpson index (OR, 0.54 [95% CI, 0.36-0.82]), sum of sialic acid-bound HMOs (0.61 [0.41-0.91]), and 3'-sialyllactose (0.67 [0.46-0.98]) were inversely associated with early AR in a fully adjusted model. A trend of interaction between sialyl-lacto-N-tetraose a (LSTa) and maternal secretor status on AR was observed in a fully adjusted model (P-value for interaction = 0.051). CONCLUSIONS: Alpha diversity, sialic acid-bound HMOs, and 3'SL may be involved in inhibiting AR in children of secretor mothers, and a trend of interactive effect of LSTa among maternal secretor status on AR was indicated. These findings offer novel perspectives on the associations between breastfeeding and a child's adiposity as well as potential metabolic disorders later in life. REGISTRY NUMBER/WEBSITE: https://www.umin.ac.jp/ (trial registration number: UMIN000047160).
Impact of maternal smoking and secondhand smoke exposure during singleton pregnancy on placental abruption: analysis of a prospective cohort study (the Japan Environment and Children's Study). 国際誌

Hikaru Karumai-Mori, Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

BMJ open　15　(3)　e089499　2025年3月4日

DOI： 10.1136/bmjopen-2024-089499 　

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OBJECTIVES: This study aimed to investigate the association and population-attributable fraction (PAF) of maternal smoking and secondhand smoke (SHS) exposure during pregnancy with placental abruption. DESIGN: Prospective cohort study. SETTING: 15 regional centres in Japan. PARTICIPANTS: Pregnant women registered between January 2011 and March 2014 from the Japan Environment and Children's Study. OUTCOME MEASURES: Data were transcribed from medical records and two self-administered questionnaires. The outcome measure was the incidence of placental abruption. Maternal smoking exposure during pregnancy was categorised based on the number of cigarettes smoked (≤10 or ≥11 cigarettes per day). SHS exposure during pregnancy was evaluated by frequency and duration (almost never or never, 1-3 days/week and/or <1 hour/day and 4-7 days/week and ≥1 hour/day). A modified Poisson regression model, adjusted for known placental abruption risk factors, calculated the risk ratio (RR) and PAF for placental abruption with a 95% Cl. RESULTS: Of the 81 974 eligible pregnant women, pregnant women smoking ≥11 cigarettes/day during pregnancy had a significantly higher risk of placental abruption. The adjusted RR (aRR) was 2.21 (95% CI 1.21 to 4.06), and the adjusted PAF (aPAF) was 1.90% (95% CI 0.09 to 3.71%). Pregnant women among never-smokers with SHS exposure of 4-7 days/week and ≥1 hour/day had a significantly higher risk (aRR: 2.34, 95% CI 1.29 to 4.28), and the aPAF was 1.89% (95% CI -0.05 to 3.83). Additionally, pregnant women among those who smoked during pregnancy with similar SHS exposure had a significantly higher risk (aRR: 2.21, 95% CI 1.30 to 3.76), with the aPAF of 2.29% (95% CI 0.11 to 4.48). CONCLUSIONS: Maternal smoking and SHS exposure during pregnancy significantly contribute to the risk of placental abruption in Japan. Therefore, preventive interventions and measures to reduce exposure are required to prevent placental abruption.
Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation.

Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Masato Takase, Kotaro Nochioka, Kai Susukita, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

Circulation journal : official journal of the Japanese Circulation Society　2025年1月11日

DOI： 10.1253/circj.CJ-24-0780 　

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BACKGROUND: The primary prevention of atrial fibrillation (AF), which increases mortality through complications including stroke and heart failure, is important. Excessive salt intake and low potassium intake are risk factors for cardiovascular disease; however, their association with AF remains inconclusive. This study investigated the association between sodium- and potassium-related urinary markers and AF prevalence. METHODS AND RESULTS: Data from the Tohoku Medical Megabank Project Community-based Cohort Study were used in this cross-sectional study. The urinary sodium-to-potassium (Na/K) ratio and estimated 24-h sodium and potassium excretion were calculated using spot urine samples and categorized into quartiles (Q1-Q4). The prevalence of AF was the primary outcome. Of the 26,506 participants (mean age 64.8 years; 33.2% males) included in this study, 630 (2.4%) had AF. Using Q1 as the reference group, the odds ratios for AF prevalence in Q4 were 1.35 (95% confidence interval [CI] 1.07-1.73) and 1.59 (95% CI 1.20-2.12) for 24-h estimated urinary Na/K ratio and estimated 24-h sodium excretion, respectively. Estimated 24-h potassium excretion was not associated with AF prevalence. CONCLUSIONS: AF prevalence was positively associated with the urinary Na/K ratio and estimated 24-h urinary sodium excretion, but not with estimated 24-h urinary potassium excretion. Although further prospective studies are warranted, the findings of this study suggest that salt intake may be a modifiable risk factor for AF.
Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

Journal of diabetes investigation　2025年1月11日

DOI： 10.1111/jdi.14400 　

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AIMS: This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM). METHODS: In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30-34.9 years. RESULTS: Higher maternal age was associated with higher odds of early and late GDM (P-value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35-39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134-1.725) and 2.494 (95% CI: 1.828-3.402), respectively. The aORs for late GDM with maternal age of 35-39 years and ≥40 were 1.603 (95% CI: 1.384-1.857) and 2.276 (95% CI: 1.798-2.881), respectively. CONCLUSIONS: Higher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM.
Inclination of antidepressant medication continuation during pregnancy between 2012 and 2023 in Japan: A cohort study. 国際誌

Tomofumi Ishikawa, Takamasa Sakai, Aoi Noda, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, M Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Journal of affective disorders　2025年1月10日

DOI： 10.1016/j.jad.2025.01.044 　

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BACKGROUND: As multiple Japanese academic societies have recently issued treatment guidelines for perinatal antidepressant treatments, it is considered worthwhile to evaluate the latest trends and continuation of antidepressant medication during pregnancy to optimize antenatal prescriptions. METHODS: The prevalence, trend, and continuation of antidepressant use during pregnancy in Japan from 2012 to 2023 were evaluated, using a large administrative claims database, in women whose pregnancies ended in live births. Annual changes were evaluated using a multivariate logistic regression model adjusted for maternal age at delivery. RESULTS: Of 179,797 women with a mean maternal age at delivery of 32.5 years, 1870 (1.04 %) were prescribed antidepressants during pregnancy. The prevalence significantly increased (P < 0.0001) from 0.63 % in 2012 to 1.67 % in 2023. Antidepressants were prescribed to 1730 women (0.96 %) during the first trimester. Of these, 670 (38.7 %) were antidepressant continuers throughout pregnancy, showing a significant increase (P < 0.0001) from 19.51 % in 2012 to 50.70 % in 2023. The most frequently prescribed class of antidepressants during pregnancy was serotonin reuptake inhibitors (0.74 %), especially sertraline (0.33 %) and escitalopram (0.23 %), with a significant increase in their annual prevalence. LIMITATIONS: Prescriptions for women whose pregnancies ended in abortion or stillbirth could not be evaluated. CONCLUSIONS: Given that antidepressant use and its continuation during pregnancy have become more common, it is important to further disseminate knowledge of the guidelines to healthcare professionals and women of childbearing age, including the promotion of preconception care and shared decision-making.
Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. 国際誌

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Takahiro Tabuchi, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Takahito Nasu, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Yoko Izumi, Atsushi Hozawa

BMJ public health　3　(1)　e001746　2025年1月

DOI： 10.1136/bmjph-2024-001746 　

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OBJECTIVES: Previous studies have assessed the impact of active smoking on mortality using the population-attributable fraction (PAF). However, these studies have not included second-hand smoking (SHS), potentially underestimating smoking's impact. We compared the PAF from active smoking alone with the PAF, including SHS exposure. DESIGN: Prospective cohort study. SETTING: A community-based cohort study in Japan. PARTICIPANTS: 40 796 participants aged ≥20 years. MAIN OUTCOME MEASURES: SHS was defined as inhaling someone else's cigarette smoke at the workplace or home in the past year. We classified smoking status and SHS into ten categories: never-smoker without SHS, never-smoker with SHS, past smoker without SHS, past smoker with SHS, current smoker 1-9 cigarettes/day without SHS, current smoker 1-9 cigarettes/day with SHS, 10-19 cigarettes/day without SHS, 10-19 cigarettes/day with SHS, ≥20 cigarettes/day without SHS and ≥20 cigarettes/day with SHS. The main outcome was all-cause mortality. RESULTS: During the median follow-up period of 6.5 (5.7-7.5) years, 788 men and 328 women died. For men, compared with never-smokers without SHS, past smokers without SHS (HR, 1.39 [95% CI, 1.11 to 1.73]) and past smokers with SHS (HR, 1.48 (95% CI, 1.10 to 2.00)) were associated with all-cause mortality. For women, never-smokers with SHS had a significantly higher risk of all-cause mortality (HR, 1.36 (95% CI, 1.00 to 1.84)). Without considering SHS, 28.0% and 2.3% of all-cause mortality in men and women, respectively, were attributable to past and current smoking. Including SHS, PAF increased to 31.3% in men and 8.4% in women. CONCLUSIONS: We clarified that smoking's impact was underestimated by not accounting for SHS, especially in women. Information on SHS is crucial for understanding smoking's health impact. This study supports the importance of avoiding smoking and preventing SHS.
Pregnancy and Postpartum Trends in Self-Measured Blood Pressure and Derived Indices: The BOSHI Study. 国際誌

Seiya Izumi, Misato Nishimura, Noriyuki Iwama, Hasumi Tomita, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Takahisa Murakami, Michihiro Satoh, Takuo Hirose, Masatoshi Saito, Takayoshi Ohkubo, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

Journal of clinical hypertension (Greenwich, Conn.)　27　(1)　e14949　2025年1月

DOI： 10.1111/jch.14949 　

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In this study, we aimed to reveal the trends of self-measured blood pressure (SMBP) and SMBP-derived indices during pregnancy and the postpartum period. The Babies and Their Parents Longitudinal Observation in Suzuki Memorial Hospital in the Intrauterine Period (BOSHI) Study is a prospective cohort study in Japan. Participants were instructed to measure SMBP daily during pregnancy and for 1 month after delivery. Among 237 participants with normotensive blood pressure (BP) during pregnancy and the postpartum period who were analyzed using mixed-effects models for repeated measures, the SMBP was measured, on average, 14.3 times from the day before delivery to 28 days postpartum. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the day before delivery were 110.6 ± 1.0 and 68.1 ± 0.8 mmHg (estimate ± standard error). Postpartum BP increased from postpartum Days 3-8 in SBP and from Days 3-22 in DBP, compared to that on the day before delivery. The SBP and DBP were 4.9 and 4.7 mmHg higher on postpartum Days 8 and 7 than the day before pregnancy, respectively. During pregnancy, the pulse rate (PR) showed an inverted U-shaped trend and then sharply increased rapidly until the first postpartum day after delivery. The Shock Index showed a similar trend to that of the PR, decreased from labor until postpartum Day 8, and plateaued thereafter. The double product peaked during labor, remained higher than the prelabor levels for approximately 10 days, and then decreased in the postpartum period.
Validity of a self-administered food frequency questionnaire for genomic and omics research among pregnant women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, Ribeka Takachi, Shiori Sugawara, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Masayuki Yamamoto, Shinichi Kuriyama

Journal of epidemiology　2024年12月21日

DOI： 10.2188/jea.JE20240293 　

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BACKGROUND: The Tohoku Medical Megabank Project has initiated the Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) including genomic and omics investigations, and conducted a self-administered food frequency questionnaire with the response option "constitutionally unable to eat or drink it" for individual food items (TMM-FFQ) for pregnant women. This study evaluated the validity of the TMM-FFQ among pregnant women. METHODS: Participants comprised 122 pregnant women aged ≥20 years residing in Miyagi Prefecture who completed weighed food records (WFRs) for 3 days as reference intake and the TMM-FFQ during mid-pregnancy. Correlations between nutrient or food group intakes based on the WFR and the TMM-FFQ were calculated using Spearman's rank correlation coefficients (CCs), adjusting for energy intake and correcting for random within-individual variation of WFR. Cross-classification was also conducted according to quintiles using the WFR and TMM-FFQ data. RESULTS: The percentages of participants who chose the "constitutionally unable to eat or drink it" option were >3% for seven food and drink items. CCs were >0.30 for 31 nutrients; the median across energy and 44 nutrients was 0.41. CCs were >0.30 for 14 food groups; the median across 20 food groups was 0.35. The median percentages of cross-classification into exact plus adjacent quintiles and extreme quintiles were 63.1% and 3.3% for energy and nutrients and 61.9% and 4.1% for food groups, respectively. CONCLUSIONS: The validity of the TMM-FFQ compared with the WFR was reasonable for certain nutrients and food groups among pregnant women in the TMM BirThree Cohort Study.
Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self-harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(4)　e70025　2024年12月

DOI： 10.1002/pcn5.70025 　

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AIM: The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self-harm ideation (SHI) at 1 month postpartum. METHODS: A sample of 12,358 postpartum women answered the EPDS and questionaries at 1, 6, and 12 months postpartum longitudinally. RESULTS: For participants with postpartum depression (PPD; EPDS total score ≥9) and SHI (SHI sub-score ≥1) at 1 month postpartum, the risk of depression at 6 and 12 months postpartum (odds ratio [95% confidence interval] at 6 and 12 months postpartum: 20.03 [16.8-23.8] and 14.55 [12.3-17.2], respectively) was higher than for those with PPD but without SHI at 1 month postpartum (OR: 8.57 [7.36-10.0], and 6.24 [5.38-7.24], respectively). Additionally, SHI even without depressive symptoms at 1 month postpartum is also a risk for depression at 6 and 12 months postpartum. To support our longitudinal evaluation of depression at 6 and 12 months postpartum, these related factors were examined: traumatic events or relocations after the Great East Japan Earthquake, employment status, household income, personality traits, sleep status, psychological distress, and social networks. The result showed employment status, low household income and poor social networks were significantly associated with depression at 12 months postpartum but not at 6 months postpartum. CONCLUSION: This study showed a high risk of depression at 6 and 12 months postpartum for those who had depressive symptoms with SHI at 1 month postpartum. Our findings may contribute to the precise evaluation of depression at 6 and 12 months postpartum while considering sleep status, psychological distress and social network during pregnancy.
症例血管型Ehlers-Danlos症候群合併妊娠の周産期管理:症例報告と文献的レビュー

熊谷奈津美, 富田芙弥, 星合哲郎, 岩間憲之, 只川真理, 濱田裕貴, 齋藤翔子, 秋山志津子, 埴田卓志, 小原拓, 谷垣伸治, 古庄知己, 青木洋子, 齋藤昌利

周産期医学　54　(11)　1562-1565　2024年11月10日
出版者・発行元：東京医学社
DOI： 10.24479/peri.0000001795 　

ISSN：0386-9881
Early prediction of hypertensive disorders of pregnancy toward preventive early intervention. 国際誌

Satoshi Mizuno, Satoshi Nagaie, Junichi Sugawara, Gen Tamiya, Taku Obara, Mami Ishikuro, Shinichi Kuriyama, Nobuo Yaegashi, Hiroshi Tanaka, Masayuki Yamamoto, Soichi Ogishima

AJOG global reports　4　(4)　100383-100383　2024年11月

DOI： 10.1016/j.xagr.2024.100383 　

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BACKGROUND: Various disease prediction models have been developed, capitalizing on the wide use of electronic health records, but environmental factors that are important in the development of noncommunicable diseases are rarely included in the prediction models. Hypertensive disorders of pregnancy are leading causes of maternal morbidity and mortality and are known to cause several serious complications later in life. OBJECTIVE: This study aims to develop early hypertensive disorders of pregnancy prediction models using comprehensive environmental factors based on self-report questionnaires in early pregnancy. STUDY DESIGN: We developed machine learning and artificial intelligence models for the early prediction of hypertensive disorders of pregnancy using early pregnancy data from approximately 23,000 pregnancies in the Tohoku Medical Megabank Birth and Three Generation Cohort Study. We clarified the important features for prediction based on regression coefficients or Gini coefficients of the interpretable artificial intelligence models (i.e., logistic regression, random forest and XGBoost models) among our developed models. RESULTS: The performance of the early hypertensive disorders of pregnancy prediction models reached an area under the receiver operating characteristic curve of 0.93, demonstrating that the early hypertensive disorders of pregnancy prediction models developed in this study retain sufficient performance in hypertensive disorders of pregnancy prediction. Among the early prediction models, the best performing model was based on self-reported questionnaire data in early pregnancy (mean of 20.2 gestational weeks at filling) which consist of comprehensive lifestyles. The interpretation of the models reveals that both eating habits were dominantly important for prediction. CONCLUSION: We have developed high-performance models for early hypertensive disorders of pregnancy prediction using large-scale cohort data from the Tohoku Medical Megabank project. Our study clearly revealed that the use of comprehensive lifestyles from self-report questionnaires led us to predict hypertensive disorders of pregnancy risk at the early stages of pregnancy, which will aid early intervention to reduce the risk of hypertensive disorders of pregnancy.
Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Chikana Kawaguchi, Maki Ozawa, Takanori Hidaka, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Masatsugu Orui, Taku Obara, Yumiko Ito, Takashi Kakinuma, Kazuhiro Kudoh, Hiroaki Ozawa, Satoshi Nakagawa, Masato Mizuashi, Ryoko Omori, Masatoshi Deguchi, Yumi Kanbayashi, Masayuki Asano, Toshiya Takahashi, Muneo Tanita, Masahiro Hara, Kenshi Yamasaki, Takayoshi Tadaki, Hiromi Suzuki, Katsuko Kikuchi, Kenichiro Tsuchiyama, Takenobu Ohashi, Shu Sasai, Motoko Honda, Taku Fujimura, Sadanori Furudate, Yoshiko Kagimoto, Maki Kawamura, Nobuko Tabata, Rika Chikama, Hiromi Komatsu, Yota Sato, Kayo Tanita, Yutaka Kimura, Shino Yusa, Hitoshi Terui, Hisayuki Tono, Yusuke Muto, Shinichi Kuriyama, Masayuki Yamamoto, Setsuya Aiba

Allergology international : official journal of the Japanese Society of Allergology　2024年10月18日

DOI： 10.1016/j.alit.2024.09.008 　

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BACKGROUND: Precise skin phenotypic data are indispensable in accurately diagnosing atopic dermatitis (AD). Therefore, this study examined the interobserver concordance for AD and non-AD diagnoses between two dermatologists. AD prevalence determined by the self-reported physician diagnoses and the diagnoses determined from the United Kingdom (UK) diagnostic criteria were compared with the diagnoses made by the two dermatologists, using data from a skin health survey. METHODS: This study included 1,638 children that participated in the skin health survey, which was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. AD was assessed using dermatologist assessments, self-reported physician diagnoses, and the UK diagnostic criteria. The concordance for diagnoses was evaluated using kappa. The sensitivity and specificity of the self-reported physician diagnoses and the UK diagnostic criteria were calculated by comparing them with the two dermatologists' diagnoses. RESULTS: Among the 1,638 children, 393 (24.0 %), 194 (11.9 %), and 597 (37.2 %) were diagnosed with AD by the two dermatologists, physicians, and the UK diagnostic criteria, respectively. The kappa (95 % CI) of the interobserver concordance for AD or non-AD diagnoses between the two dermatologists was 0.78 (0.75-0.81). The sensitivity and specificity of the self-reported physician diagnoses were 26.7 % and 94.1 %, respectively. The sensitivity and specificity of the UK diagnostic criteria were 85.0 % and 82.4 %, respectively. CONCLUSIONS: Interobserver concordance for AD or non-AD diagnoses between the two dermatologists was substantial. Self-reported physician diagnoses exhibited low sensitivity that potentially indicated underdiagnosis of AD, whereas the UK diagnostic criteria might overdiagnose AD.
Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Mami Ishikuro, Taku Obara, Mayu Hasegawa, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Noriyuki Iwama, Masahiro Kikuya, Junichi Sugawara, Tatsuhiko Azegami, Takashin Nakayama, Asako Mito, Naoko Arata, Hirohito Metoki, Takeshi Kanda, Shinichi Kuriyama

Hypertension research : official journal of the Japanese Society of Hypertension　2024年10月11日

DOI： 10.1038/s41440-024-01936-9 　

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Hypertensive disorders of pregnancy can cause hypertension in the future. Understanding how the blood pressure values of women with and without hypertensive disorders of pregnancy differ will facilitate follow-up blood pressure monitoring in clinical settings. This study investigated the association between hypertensive disorders of pregnancy and subsequent high blood pressure and hypertension. This study used Japanese data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Follow-up systolic and diastolic blood pressures in normotensive women during pregnancy and those with hypertensive disorders of pregnancy were estimated using analysis of covariance adjusted for women with low birthweight, history of gestational diabetes mellitus, age, body mass index, pulse rate, smoking and drinking at the follow-up assessment, paternal hypertension history, and maternal hypertension or hypertensive disorders of pregnancy history. Finally, we performed a multiple logistic regression analysis. In total, 7343 women were included in the analysis. Women with a history of hypertensive disorders of pregnancy had higher blood pressure approximately three years postpartum compared with normotensive women. Hypertensive disorders of pregnancy in the most recent pregnancy in different subgroups, such as nulliparous women, multiparous women without a history of hypertensive disorders of pregnancy, and multiparous women with a history of hypertensive disorders of pregnancy, were associated with an increased risk of subsequent hypertension. Women's birthweight was also weakly associated with hypertension. Even one experience of hypertensive disorders of pregnancy may contribute to elevated blood pressure and hypertension approximately three years postpartum. In addition, women's birthweights may have a weak relationship with increasing blood pressure.
Identification of risk loci for postpartum depression in a genome-wide association study. 国際誌

Xue Li, Nagahide Takahashi, Akira Narita, Yukako Nakamura, Mika Sakurai-Yageta, Keiko Murakami, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Fumihiko Ueno, Hirohito Metoki, Hisashi Ohseto, Ippei Takahashi, Tomohiro Nakamura, Noriko Warita, Tomoka Shoji, Zhiqian Yu, Chiaki Ono, Natsuko Kobayashi, Saya Kikuchi, Tasuku Matsuki, Fuji Nagami, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Norio Ozaki, Gen Tamiya, Shinichi Kuriyama, Hiroaki Tomita

Psychiatry and clinical neurosciences　2024年9月17日

DOI： 10.1111/pcn.13731 　

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AIM: Genome-wide association studies (GWAS) of postpartum depression (PPD) based on accumulated cohorts with multiple ethnic backgrounds have failed to identify significantly associated loci. Herein, we conducted a GWAS of Japanese perinatal women along with detailed confounding information to uncover PPD-associated loci. METHODS: The first and second cohorts (n = 9260 and n = 8582 perinatal women enrolled in the Tohoku Medical Megabank Project) and the third cohort (n = 997), recruited at Nagoya University, underwent genotyping. Of them, 1421, 1264, and 225 were classified as PPD based on the Edinburgh Postnatal Depression Scale 1 month after delivery. The most influential confounding factors of genetic liability to PPD were selected, and logistic regression analyses were performed to evaluate genetic associations with PPD after adjusting for confounders. RESULTS: A meta-analysis of GWAS results from the three cohorts identified significant associations between PPD and the following loci (P < 5 × 10-8) by integrating the number of deliveries and the number of family members living together as the most influential confounders: rs377546683 at DAB1, rs11940752 near UGT8, rs141172317, rs117928019, rs76631412, rs118131805 at DOCK2, rs188907279 near ZNF572, rs504378, rs690150, rs491868, rs689917, rs474978, rs690118, rs690253 near DIRAS2, rs1435984417 at ZNF618, rs57705782 near PTPRM, and rs185293917 near PDGFB. Pathway analyses indicated that SNPs suggestively associated with PPD were mostly over-represented in categories including long-term depression, GnRH signaling, glutamatergic synapse, oxytocin signaling, and Rap1 signaling. CONCLUSION: The current GWAS study identified eight loci significantly associated with PPD, which may clarify the genetic structure underlying its pathogenesis.
Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricaemia in a Japanese Population

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Biobank Japan Project; Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Rheumatology　2024年9月13日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/rheumatology/keae492 　

ISSN：1462-0324

eISSN：1462-0332

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Abstract Objective To investigate the inter-relationships among genetic risk, healthy lifestyle adherence, and hyperuricaemia susceptibility. Methods This prospective cohort study was conducted with 7,241 hyperuricaemia-free individuals aged ≥ 20 years from the Tohoku Medical Megabank Community-based cohort study. A comprehensive lifestyle score included body mass index, smoking, drinking, and physical activity, and a polygenic risk score (PRS) was constructed based on uric acid loci from a previous genome-wide association study meta-analysis. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and hyperuricaemia incidence and calculate the area under the receiver operating characteristic curve (AUROC). Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dl or a self-reported history of hyperuricaemia. Results Of the 7,241 adults (80.7% females; mean [SD] age: 57.7 [12.6] years), 217 (3.0%) developed hyperuricaemia during 3.5 years of follow-up. Genetic risk correlated with hyperuricaemia development (P for interaction = 0.287), and lifestyle risks were independently associated. Those with a high genetic risk and poor lifestyle had the highest risk (odds ratio: 5.34; 95% confidence interval [CI]: 2.61–12.10). Although not statistically significant, incorporating the PRS in the model with lifestyle information improved predictive ability (AUROC = 0.771, 95% CI: 0.736–0.806 for lifestyle; AUROC = 0.785, 95% CI: 0.751–0.819 for lifestyle and PRS; p = 0.07). Conclusion : A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk. Genetic risk may complement lifestyle factors in identifying individuals at a heightened hyperuricaemia risk.
Association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. 国際誌

Tomofumi Ishikawa, Takamasa Sakai, Noriyuki Iwama, Ryo Obara, Kei Morishita, Motohiko Adomi, Aoi Noda, Mami Ishikuro, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, Masatoshi Saito, Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Acta psychiatrica Scandinavica　2024年9月5日

DOI： 10.1111/acps.13755 　

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OBJECTIVE: To evaluate the association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. MATERIAL AND METHODS: This nested case-control study used a large Japanese administrative database. Pregnancy onset and outcomes were estimated using previously reported algorithms, classifying cases as women becoming pregnant between 2013 and 2022 and ending in a miscarriage. Controls were randomly selected from the entire pregnancy cohort by risk-set sampling with replacement and were individually matched to the cases (3:1). The association between exposure to atypical antipsychotics and risk of miscarriage was assessed using conditional logistic regression adjusted for confounders. The association between benzodiazepine exposure and the risk of miscarriage was assessed as a positive control. RESULTS: In the cohort, 44,118 patients were matched with 132,317 controls. The mean ages (standard deviations) of the case and control groups were 33.3 (5.7) and 33.2 (5.5) years, respectively. The prevalence of atypical antipsychotics was 0.5% in both groups. Aripiprazole is an individual antipsychotic with the highest prescription prevalence. The adjusted odds ratios (aOR) for miscarriage were 0.966 (95% confidence interval [CI], 0.796-1.173) for atypical antipsychotics and 0.998 (0.784-1.269) for aripiprazole. A higher aOR (1.431, 95% CI 1.303-1.573) suggested an association with benzodiazepines. A sensitivity analysis that limited the population to women diagnosed with schizophrenia alone did not suggest an association between atypical antipsychotics and the risk of miscarriage. CONCLUSIONS: The results of this study do not suggest an association between exposure to atypical antipsychotics during pregnancy and the risk of miscarriage.
Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Ippei Takahashi, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Ryo Obara, Aoi Noda, Minoru Ohsawa, Tomofumi Ishikawa, Nariyasu Mano, Hidekazu Nishigori, Fumihiko Ueno, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(3)　e226　2024年9月

DOI： 10.1002/pcn5.226 　

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AIM: To examine the association of the combination of taking neuropsychiatric medications from the onset of pregnancy to mid-pregnancy and maternal psychological distress at mid-pregnancy, with children's behavioral problems. METHODS: Neuropsychiatric medication use from the onset of pregnancy to mid-pregnancy was defined by the self-reported name of the neuropsychiatric medication in the questionnaire in early and mid-pregnancy. Maternal psychological distress was defined by the Kessler Psychological Distress Scale (K6) ≥13 on the questionnaire in mid-pregnancy. We classified the participants into four categories based on the combination of taking neuropsychiatric medications and psychological distress: "None," "Medications only," "K6 ≥ 13 only," and "Both." Children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) at 2 years of age. The clinical ranges of the internalizing and externalizing scales of the CBCL were defined as behavioral problems. We conducted a multivariable logistic regression analysis to examine the associations between the four categories of maternal exposure and children's behavioral problems. RESULTS: Compared with the "None" category (n = 9873), the "K6 ≥ 13 only" category (n = 308) was statistically significantly associated with internalizing and externalizing problems. In contrast, the "Medications only" (n = 93) and "Both" (n = 22) categories were not statistically significantly associated with internalizing and externalizing problems, although the point estimates of the odds ratio in the "Both" category were relatively high (1.58 for the internalizing problem and 2.50 for the externalizing problem). CONCLUSION: The category of mothers taking neuropsychiatric medications and having no psychological distress during pregnancy was not associated with children's behavioral problems in the present population.
Genome-wide association study based on clustering by obesity-related variables uncovers a genetic architecture of obesity in the Japanese and the UK populations. 国際誌

Ippei Takahashi, Hisashi Ohseto, Fumihiko Ueno, Tomomi Oonuma, Akira Narita, Taku Obara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Atsushi Hozawa, Junichi Sugawara, Gen Tamiya, Shinichi Kuriyama

Heliyon　10　(16)　e36023　2024年8月30日

DOI： 10.1016/j.heliyon.2024.e36023 　

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Whether all obesity-related variants contribute to the onset of obesity or one or a few variants cause obesity in genetically heterogeneous populations remains obscure. Here, we investigated the genetic architecture of obesity by clustering the Japanese and British populations with obesity using obesity-related factors. In Step-1, we conducted a genome-wide association study (GWAS) with body mass index (BMI) as the outcome for eligible participants. In Step-2, we assigned participants with obesity (BMI ≥25 kg/m2) to five clusters based on obesity-related factors. Subsequently, participants from each cluster and those with a BMI <25 kg/m2 were combined. A GWAS was conducted for each cluster. Several previously identified obesity-related genes were verified in Step-1. Of the genes detected in Step-1, unique obesity-related genes were detected separately for each cluster in Step-2. Our novel findings suggest that a smaller sample size with increased homogeneity may provide insights into the genetic architecture of obesity.
Child-parent associations of hematocrit in trios of Japanese adulthood confirmed by the random family method: The TMM BirThree Cohort Study. 国際誌

Takuma Usuzaki, Mami Ishikuro, Masahiro Kikuya, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

Scientific reports　14　(1)　19047-19047　2024年8月16日

DOI： 10.1038/s41598-024-69752-2 　

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To examine child-parent associations of HCT among Japanese adults and their parents. Factors associated with hematocrit (HCT) were analyzed in 3,574 sons and 7,203 daughters using Pearson's correlation coefficient and Student's t-test. Multiple linear regression analysis, adjusted by the factors identified by univariate analyses and by living with parents, was performed on 242 son-parent trios and 587 daughter-parent trios. When a child-parent association was observed in the multiple linear regression analysis, it was validated using the random family method (RFM). In univariate analyses, the son's HCT was associated with age (correlation coefficient = -0.072), white blood cell (WBC) (0.19), alanine aminotransferase (ALT) (0.20), triglyceride (0.11), and estimated glomerular filtration rate (eGFR) (- 0.087). The daughter's HCT was associated with WBC (0.014), ALT (0.18), and eGFR (- 0.17). In multiple linear regression analysis, the son's HCT was associated with the son's WBC (coefficient = 3.48 × 10-4), the son's eGFR (0.031), the father's HCT (0.11), and the mother's HCT (0.17). RFM confirmed the association between the son's and father's HCT (p = 0.0070) and between the son's and mother's HCT (p = 0.0011). The daughter's HCT was associated with WBC (2.6 × 10-4), ALT (0.037), and the mother's HCT (0.14). RFM confirmed the association between the daughter's and mother's HCT (p = 0.00043). Child-parent association of HCT was confirmed between son-father, son-mother, and daughter-mother relationships, and differed depending on the sex of the child and the parents.
The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. 国際誌

Hiromi Himuro, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Naho Tsuchiya, Takumi Hirata, Masatsugu Orui, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Akira Uruno, Nobuo Fuse, Satoshi Nagaie, Soichi Ogishima, Mami Ishikuro, Taku Obara, Yoko Izumi, Masatoshi Saito, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

Hypertension research : official journal of the Japanese Society of Hypertension　2024年8月8日

DOI： 10.1038/s41440-024-01827-z 　

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This study aimed to investigate the association of combination of birth weight and current body mass index (BMI) with the risk of hypertension in adulthood. This cross-sectional study used data from the Tohoku Medical Megabank Community-based Cohort Study conducted in Japan. A total of 10,688 subjects aged ≥20 years were eligible. We calculated the least square (LS) means of systolic blood pressure (SBP) and trend tests were performed to evaluate the linear relationships between birth weight categories and SBP. We also used a multivariate logistic regression analysis to assess the risk of hypertension associated with the combination of birth weight and current BMI. There was a statistically inverse association between birth weight and SBP in the 20-64 age group, but no significant association in the ≥65 age group. Low birth weight (LBW) with normal BMI group had a higher risk of hypertension than the normal or high birth weight groups with normal BMI. Furthermore, the group with LBW and BMI ≥25.0 kg/m2 was the highest risk for hypertension (adjusted odds ratio: 2.73; 95% CI, 2.04-3.65) compared to the reference group (birth weight 2500-3499 g and BMI 18.5-24.9 kg/m2). There was a significant association between LBW and subsequent risk of hypertension. In addition, participants with lower birth weights had a higher risk of hypertension than those with higher birth weights. However, even in participants with a lower birth weight, the risk of hypertension could be reduced when they maintained an optimal BMI.
Trends in prescribing nifedipine and amlodipine to pregnant women after related contraindications were lifted in Japan

Daisuke Kikuchi, Taku Obara, Hiroyuki Suzuki, Taisuke Konno, Kouji Okada, Hitoshi Nakamura, Yuriko Murai

Hypertension Research　2024年8月2日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-024-01821-5 　

ISSN：0916-9636

eISSN：1348-4214
Comparison of renal prognosis between dipeptidyl peptidase-4 inhibitor users and non-users. 国際誌

Hideaki Hashimoto, Michihiro Satoh, Shingo Nakayama, Maya Toyama, Takahisa Murakami, Taku Obara, Naoki Nakaya, Takefumi Mori, Atushi Hozawa, Hirohito Metoki

Diabetes, obesity & metabolism　2024年7月31日

DOI： 10.1111/dom.15800 　

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AIM: To evaluate the renal prognosis of dipeptidyl peptidase-4 inhibitor (DPP-4i) users and non-users using real-world Asian data. METHODS: Using databases from DeSC Healthcare, Inc., patients aged 30 years or older who used antidiabetic drugs from 2014 to 2021 were identified. Propensity score matching analyses were used to compare renal prognosis between DPP-4i users and non-users. The primary outcomes were estimated glomerular filtration rate (eGFR) decline and end-stage kidney disease (ESKD) development in the eGFR of 45 mL/min/1.73m2 or higher and eGFR of less than 45 mL/min/1.73m2 groups, respectively. RESULTS: In total, 65 375 and 9866 patients were identified in the eGFR of 45 mL/min/1.73m2 or higher and eGFR of less than 45 mL/min/1.73m2 groups, respectively. In the eGFR of 45 mL/min/1.73m2 or higher group, propensity score matching created 16 002 pairs. A significant difference was observed in the primary outcome of eGFR decline between DPP-4i users and non-users at 2 years (-2.31 vs. -2.56 mL/min/1.73m2: difference, 0.25 mL/min/1.73m2; 95% confidence interval [CI], 0.06-0.44) and 3 years (-2.75 vs. -3.41 mL/min/1.73m2: difference, 0.66 mL/min/1.73m2; 95% CI, 0.39-0.93). In the eGFR less than 45 mL/min/1.73m2 group, propensity score matching created 2086 pairs. After a mean of 2.2 years of observation, ESKD development was 1.15% and 2.30% in users and non-users, respectively, and Kaplan-Meier analysis revealed a significant difference (log rank P = .005). CONCLUSIONS: This retrospective real-world study revealed that patients using DPP-4is had a better renal prognosis than those not using DPP-4is.
Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study.

Seiya Izumi, Noriyuki Iwama, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Michihiro Satoh, Takahisa Murakami, Masatoshi Saito, Takayoshi Ohkubo, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

Endocrine journal　2024年7月26日

DOI： 10.1507/endocrj.EJ23-0568 　

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This study aimed to evaluate the associations of fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) levels at <24 weeks of gestation with hypertensive disorders of pregnancy (HDP) and compare the strengths of the associations of HDP with FPG and HbA1c levels. Totally, 1,178 participants were included in this prospective cohort study. HDP, FPG, HbA1c, and potential confounding factors were included in multiple logistic regression models. The number of HDP cases was 136 (11.5%). When FPG and HbA1c were included in the model separately, quartile 4 (Q4) of FPG (87-125 mg/dL) and HbA1c (5.2-6.3% [33-45 mmol/mol]) levels had higher odds of HDP than quartile 1. The odds ratios (ORs) were 1.334 (95% confidence interval [CI]: 1.002-1.775) for Q4 of FPG and 1.405 (95% CI: 1.051-1.878) for Q4 of HbA1c. When the participants were divided into two categories based on the cut-off value with the maximum Youden Index of FPG or HbA1c, the ORs for high FPG (≥84 mg/dL) or high HbA1c (≥5.2% [33 mmol/mol]) were 1.223 (95% CI: 1.000-1.496) and 1.392 (95% CI: 1.122-1.728), respectively. When both FPG and HbA1c were included in the model simultaneously, the statistical significance of Q4 of FPG disappeared, whereas that of HbA1c remained. In two-category models, the same results were obtained. High FPG and HbA1c levels at <24 weeks of gestation were risk factors for HDP in pregnant Japanese women. In addition, high HbA1c levels were more strongly associated with HDP than high FPG levels.
How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Tomohiro Nakamura, Hirohito Metoki, Soichi Ogishima, Yoko Izumi, Naoki Nakaya, Atsushi Hozawa, Tadashi Ishii, Fuji Nagami, Masayuki Yamamoto, Shinichi Kuriyama

JMA journal　7　(3)　353-363　2024年7月16日

DOI： 10.31662/jmaj.2024-0043 　

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INTRODUCTION: To examine the interaction between lifestyle habits and the COVID-19 vaccinations for preventing SARS-CoV-2 infection, we analyzed 11,016 adult participants registered in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. METHODS: Lifestyle variables, including regular exercise, smoking and drinking habits, sleep status, body mass index, and daily breakfast consumption, were assessed from 2014 to 2019 using baseline questionnaires. Information on SARS-CoV-2 infection and the COVID-19 vaccination were also collected from March 2020 to May 2023. The study period was divided into two in the postvaccination phase: the first period (the beginning of the vaccination program) and the second period (the fourth shot onward). RESULTS: In the Cox proportional-hazards model analysis, the five-time vaccinations group showed a significantly lower risk of SARS-CoV-2 infection adjusted age, sex, underlying health condition, and lifestyle variables (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.76-0.86). Logistic regression analysis revealed that a higher number of vaccinations was significantly associated with a low risk of SARS-CoV-2 infection regardless of lifestyle habits (three times in the first period: odds ratio [OR] 0.19, 95% CI 0.15-0.24; five times in the second period: OR 0.07, 95% CI 0.05-0.11 vs. none). Regarding lifestyle habits, the risk reduction in those who had sleep satisfaction (OR 0.12, 95% CI 0.08-0.18) was slightly larger than in those who had sleep dissatisfaction (OR 0.23, 95% CI 0.17-0.32) in the group with the highest number of vaccinations in the first period; however, this interaction was hardly confirmed in the second period when the number of infected cases significantly increased. CONCLUSIONS: Our findings indicated that a higher number of COVID-19 vaccinations was associated with reduced risk of SARS-CoV-2 infection; otherwise, we may need to understand the advantages and limitations of a healthy lifestyle for preventing infection depending on the situation with vaccinations and infection spreading.
Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. 国際誌

Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2024年7月10日

DOI： 10.1038/s41440-024-01790-9 　

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Depression is comorbid with somatic diseases; however, the relationship between depressive symptoms and hypertension (HT), a risk factor for cardiovascular events, remains unclear. Home blood pressure (BP) is more reproducible and accurately predictive of cardiovascular diseases than office BP. Therefore, we focused on home BP and investigated whether depressive symptoms contributed to the future onset of home HT. This prospective cohort study used data from the Tohoku Medical Megabank Community-Cohort Study (conducted in the Miyagi Prefecture, Japan) and included participants with home normotension (systolic blood pressure (SBP) < 135 mmHg and diastolic blood pressure (DBP) < 85 mmHg). Depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale-Japanese version at the baseline survey. In the secondary survey, approximately 4 years later, the onset of home HT was evaluated (SBP ≥ 135 mmHg or DBP ≥ 85 mmHg) and was compared in participants with and without depressive symptoms. Of the 3 082 (mean age: 54.2 years; females: 80.9%) participants, 729 (23.7%) had depressive symptoms at the baseline survey. During the 3.5-year follow-up, 124 (17.0%) and 388 (16.5%) participants with and without depressive symptoms, respectively, developed home HT. Multivariable adjusted odds ratios were 1.37 (95% confidence interval (CI): 1.02-1.84), 1.18 (95% CI: 0.86-1.61), and 1.66 (95% CI: 1.17-2.36) for home, morning, and evening HT, respectively. This relationship was consistent in the subgroup analyses according to age, sex, BP pattern, and drinking habit. Depressive symptoms increased the risk of new-onset home HT, particularly evening HT, among individuals with home normotension. This prospective cohort study revealed that depressive symptoms are risk factors for new-onset home hypertension, particularly evening hypertension among individuals with home normotension. Assessing home blood pressure in individuals with depressive symptoms is important for the prevention of hypertension and concomitant cardiovascular diseases.
Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. 国際誌

Miyuki Sakurai, Ikuko N Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, Kazuki Kumada, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

Scientific reports　14　(1)　15681-15681　2024年7月8日

DOI： 10.1038/s41598-024-66180-0 　

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Understanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55-59 to 60-64 years being a period of significant metabolic change, particularly in men, and from 45-49 to 50-54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.
Associations of combined genetic and lifestyle risks with hypertension and home hypertension. 国際誌

Masato Takase, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Akira Narita, Hirohito Metoki, Michihiro Satoh, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Hypertension research : official journal of the Japanese Society of Hypertension　2024年6月24日

DOI： 10.1038/s41440-024-01705-8 　

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No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (n = 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (n = 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34-2.80) and 2.15 (1.60-2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.
Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Journal of atherosclerosis and thrombosis　2024年6月22日

DOI： 10.5551/jat.64906 　

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AIM: This study examined the relationship between genetic risk, healthy lifestyle, and risk of developing diabetes. METHODS: This prospective cohort study included 11,014 diabetes-free individuals ≥ 20 years old from the Tohoku Medical Megabank Community-based cohort study. Lifestyle scores, including the body mass index, smoking, physical activity, and gamma-glutamyl transferase (marker of alcohol consumption), were assigned, and participants were categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score (PRS) was constructed based on the type 2 diabetes loci from the BioBank Japan study. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and diabetes incidence and to calculate the area under the receiver operating characteristic curve (AUROC). RESULT: Of the 11,014 adults included (67.8% women; mean age [standard deviation], 59.1 [11.3] years old), 297 (2.7%) developed diabetes during a mean 4.3 (0.8) years of follow-up. Genetic and lifestyle score is independently associated with the development of diabetes. Compared with the low genetic risk and ideal lifestyle groups, the odds ratio was 3.31 for the low genetic risk and poor lifestyle group. When the PRS was integrated into a model including the lifestyle and family history, the AUROC significantly improved to 0.719 (95% confidence interval [95% CI]: 0.692-0.747) compared to a model including only the lifestyle and family history (0.703 [95% CI, 0.674-0.732]). CONCLUSION: Our findings indicate that adherence to a healthy lifestyle is important for preventing diabetes, regardless of genetic risk. In addition, genetic risk might provide information beyond lifestyle and family history to stratify individuals at high risk of developing diabetes.
リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

橋本英明, 佐藤倫広, 村上任尚, 遠山真弥, 中山晋吾, 小原拓, 中谷直樹, 森建文, 寳澤篤

日本腎臓学会誌　66　(4)　616-616　2024年6月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

橋本英明, 佐藤倫広, 村上任尚, 遠山真弥, 中山晋吾, 小原拓, 中谷直樹, 森建文, 寳澤篤

日本腎臓学会誌　66　(4)　616-616　2024年6月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
Maternal birth weight is an indicator of preterm delivery: The Japan environment and children's study

Rie Kudo, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Journal of Developmental Origins of Health and Disease　15　2024年5月22日

DOI： 10.1017/S2040174424000126 　

ISSN：2040-1744

eISSN：2040-1752
Associations between housing and psychological damage by earthquake and modifiable risk factors for dementia in general older adults: Tohoku Medical Megabank community-based cohort study.

Ippei Chiba, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Tomohiro Nakamura, Satoshi Nagaie, Nobuo Fuse, Taku Obara, Yuka Kotozaki, Kozo Tanno, Shinichi Kuriyama, Atsushi Hozawa

Geriatrics & gerontology international　2024年5月3日

DOI： 10.1111/ggi.14867 　

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AIM: To evaluate the association between housing and psychological damage caused by the Great East Japan Earthquake (GEJE) and modifiable risk factors (MRFs) of dementia for general population of older adults. METHODS: This cross-sectional study enrolled 29 039 community-dwelling older adults (mean age 69.1 ± 2.9 years, 55.5% women). We evaluated disaster-related damage (by complete or not complete housing damage) and psychological damage (by post-traumatic stress reaction [PTSR]) after the GEJE using a self-report questionnaire. MRFs encompassed the presence of depression, social isolation, physical inactivity, smoking, and diabetes. We examined the association between disaster-related damage and MRFs using ordinary least squares and modified Poisson regression models adjusted for sociodemographic and health status variables. RESULTS: Complete housing damage and PTSR were identified in 2704 (10.0%) and 855 (3.2%) individuals, respectively. The number of MRFs was significantly larger for the individuals with complete housing damage (β = 0.23; 95% confidence interval [CI]: 0.19-0.27) and PTSR (β = 0.60; 95% CI: 0.53-0.67). Prevalence ratios (PRs) for depression and physical inactivity were higher in individuals with complete housing damage. The PRs for all domains of the MRFs were significantly higher in individuals with PTSR. CONCLUSIONS: Housing and psychological damage caused by the GEJE were associated with an increased risk factor of dementia. To attenuate the risk of dementia, especially among older victims who have experienced housing and psychological damage after a disaster, multidimensional support across various aspects of MRFs is required. Geriatr Gerontol Int 2024; ••: ••-••.
周産期医薬品情報の創出に関する薬剤疫学研究の実施可能性に関する研究

小原拓, 岡田裕子, 菊池大輔, 近藤悠希, 酒井隆全, 佐藤泉美, 佐藤ユリ, 土屋雅美, 畠山史朗

日本医薬品情報学会総会・学術大会講演要旨集　26回　115-115　2024年5月
出版者・発行元： (一社)日本医薬品情報学会
The association between blood pressure control in women during pregnancy and adverse perinatal outcomes: the TMM BirThree Cohort Study. 国際誌

Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Masahiro Kikuya, Hirohito Metoki, Shinichi Kuriyama

Hypertension research : official journal of the Japanese Society of Hypertension　47　(5)　1216-1222　2024年5月

DOI： 10.1038/s41440-023-01570-x 　

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Blood pressure (BP) control in pregnancy is essential to prevent adverse outcomes. However, BP levels for hypertension treatment are inconsistent among various guidelines. This study investigated the association between BP control and adverse perinatal outcomes. A total of 18,155 mother-offspring pairs were classified into four groups according to BP after 20 gestational weeks: normal BP (<140/90 mmHg without antihypertensive drugs), high BP (≥140/90 mmHg without antihypertensive drugs), controlled BP (<140/90 mmHg with antihypertensive drugs), and uncontrolled BP (≥140/90 mmHg with antihypertensive drugs). The prevalence of small for gestational age was 1,087/17,476 offspring in normal BP, 78/604 in high BP, 5/42 in controlled BP, and 7/33 in uncontrolled BP. Compared to normal BP, adjusted odds ratios (ORs) (95% confidence intervals (CIs)) were 1.76 (1.32-2.35) for high BP, 2.08 (0.79-5.50) for controlled BP, and 2.34 (0.94-5.85) for uncontrolled BP (multiple logistic regression analysis). Similarly, the adjusted ORs (95% CIs) were 1.80 (1.35-2.41), 3.42 (1.35-8.63), and 5.10 (1.93-13.45) for high, controlled, and uncontrolled BPs for low birth weight, respectively; 1.99 (1.48-2.68), 2.70 (1.12-6.50), and 6.53 (3.09-13.82) for high, controlled, and uncontrolled BPs for preterm birth, respectively; 1.64 (1.19-2.24), 2.17 (0.88-5.38), and 2.12 (0.80-5.65) for high, controlled, and uncontrolled BPs for admission to the Neonatal Intensive Care Unit or Growing Care Unit, respectively; and 1.17 (0.70-1.95), 2.23 (0.65-7.68), and 0.91 (0.20-4.16) for high, controlled, and uncontrolled BPs for 1-min Apgar score < 7, respectively. BP ≥ 140/90 mmHg might be taken care for preventing various adverse perinatal outcomes.
Combined effects of blood pressure and glucose status on the risk of chronic kidney disease. 国際誌

Maya Toyama, Michihiro Satoh, Shingo Nakayama, Hideaki Hashimoto, Tomoko Muroya, Takahisa Murakami, Takuo Hirose, Taku Obara, Naoki Nakaya, Takefumi Mori, Takayoshi Ohkubo, Yutaka Imai, Atsushi Hozawa, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　2024年4月26日

DOI： 10.1038/s41440-024-01683-x 　

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This study aimed to assess the combined effects of blood pressure (BP) and glucose status on chronic kidney disease (CKD) incidence in young and middle-aged adults. We examined data from 1,297,341 Japanese individuals aged <60 years (60.1% men; mean age 41.4 ± 9.3 years) with no history of CKD at baseline. The interval-censored Cox proportional hazards model with covariates was used. During a median follow-up period of 2.1 years, new onset CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2 and/or proteinuria) occurred in 80,187 participants. In participants without antihypertensive treatment (AHT), the adjusted hazard ratios (95% confidence interval) per 1-standard deviation, that is, 15 mmHg increase in systolic BP for CKD incidence, were 1.08 (1.07-1.09), 1.12 (1.10-1.13), and 1.15 (1.12-1.18) in normoglycemia, borderline glycemia, and diabetes groups, respectively. These ratios were significantly higher in the borderline glycemia and diabetes groups compared with those in the normoglycemia group (interaction p < 0.0001). The interaction between BP and borderline glycemia was evident when the outcome definition was restricted to proteinuria. In participants under AHT, systolic BP was most strongly associated with CKD risk in the diabetes group, although no significant interaction was observed. High BP and high glucose status may synergistically increase the incidence of CKD. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population. This large-scale longitudinal cohort study showed high BP and diabetes synergistically increased the risk of CKD in individuals without AHT. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population.
Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Aoi Noda, Taku Obara, Matsuyuki Shirota, Fumihiko Ueno, Fumiko Matsuzaki, Rieko Hatanaka, Ryo Obara, Kei Morishita, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Shinichi Kuriyama

European journal of clinical pharmacology　2024年4月17日

DOI： 10.1007/s00228-024-03685-7 　

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PURPOSE: To elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: Questionnaires were distributed to pregnant women participating in the TMM BirThree Cohort Study (from July 2013 to March 2017) around 12 weeks (early pregnancy) and 26 weeks (middle pregnancy). We analysed medication use over three periods: (1) 12 months prior to pregnancy diagnosis, (2) the period between pregnancy diagnosis and around week 12 of pregnancy, and (3) post around week 12 of pregnancy. RESULTS: In total, 19,297 women were included in the analysis. The proportion of pregnant women using medications was 49.0% prior to pregnancy diagnosis, 52.1% from diagnosis to week 12, and 58.4% post week 12 of pregnancy. The most frequently prescribed medications were loxoprofen sodium hydrate (5.5%) prior to pregnancy diagnosis, magnesium oxide (5.9%) from diagnosis to week 12, and ritodrine hydrochloride (10.5%) post week 12 of pregnancy. The number of women who used suspected teratogenic medications during early pregnancy was 96 prior to pregnancy diagnosis, 48 from diagnosis to week 12, and 54 post week 12 of pregnancy. CONCLUSION: We found that ~ 50% of the pregnant women used medications before and during pregnancy and some took potential teratogenic medications during pregnancy. In birth genomic cohort study, it is expected that investigations into the safety and effectiveness of medications used during pregnancy will advance.
フェブキソスタット内服者とトピロキソスタット内服者の腎予後の比較健診・レセプトデータ分析

中山晋吾, 佐藤倫広, 遠山真弥, 橋本英明, 村上任尚, 廣瀬卓男, 小原拓, 森建文, 目時弘仁

日本循環器病予防学会誌　59　(2)　135-135　2024年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
治療有無別の血圧およびコレステロールと冠動脈疾患リスクとの関連大規模健診・レセプトデータに基づく解析

佐藤倫広, 村上任尚, 橋本英明, 遠山真弥, 中山晋吾, 小原拓, 大久保孝義, 目時弘仁

日本循環器病予防学会誌　59　(2)　134-134　2024年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study. 国際誌

Yudai Yonezawa, Ippei Takahashi, Hisashi Ohseto, Fumihiko Ueno, Tomomi Onuma, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

BMC pregnancy and childbirth　24　(1)　209-209　2024年3月20日

DOI： 10.1186/s12884-024-06376-4 　

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BACKGROUND: Nausea and vomiting during pregnancy (NVP) and hyperemesis gravidarum (HG), common conditions affecting most pregnant women, are highly heritable and associated with maternal and fetal morbidity. However, the pathologies underlying NVP and HG and their associated loci are scarce. METHODS: We performed genome-wide association studies (GWAS) of NVP in pregnant women (n = 23,040) who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan from July 2013 to March 2017. Participants were divided into discovery (n = 9,464) and replication (n = 10,051) stages based on the platform used for their genotyping. Loci that achieved the genome-wide significance level (p < 5.0 × 10- 8) in the discovery stage were selected for genotyping in the replication stage. A meta-analysis integrating the discovery and replication stage results (n = 19,515) was conducted. NVP-related variables were identified as categorical or continuous. RESULTS: GWAS analysis in the discovery phase revealed loci linked to NVP in two gene regions, 11q22.1 (rs77775955) and 19p13.11 (rs749451 and rs28568614). Loci in these two gene regions have also been shown to be associated with HG in a White European population, indicating the generalizability of the GWAS analyses conducted in this study. Of these, only rs749451 and rs28568614 at 19p13.11 reached the genome-wide suggestive level (p < 1.0 × 10- 5) in the replication stage; however, both loci were significant in the meta-analysis. CONCLUSIONS: NVP-related loci were identified in the Japanese population at 11q22.1 and 19p13.11, as reported in previous GWAS. This study contributes new evidence on the generalizability of previous GWAS on the association between genetic background and NVP.
Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Natsuko Kobayashi, Saya Kikuchi, Xue Li, Aoi Noda, Keiko Murakami, Gen Tamiya, Junichi Sugawara, Hiroaki Tomita, Shinichi Kuriyama

Depression and Anxiety　2024　1-13　2024年3月15日
出版者・発行元： Wiley
DOI： 10.1155/2024/6622666 　

ISSN：1091-4269

eISSN：1520-6394

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This study is aimed at revealing the risk factors, prognosis, influence on offspring, and genetic architecture of perinatal depression (PD) classified based on the depressive symptom trajectory. Pregnant women with no history of major depressive disorder (MDD) were recruited and followed up with their offspring from 1 to 5 years postpartum. Using four self-report questionnaires in the perinatal period, PD was classified into four subtypes: pregnancy, early postpartum, late postpartum, and chronic PD. Risk factors, depressive symptom trajectory from 1 to 5 years postpartum, and child behavior problems were compared among the four PD subtypes. Genome-wide association studies (GWASs) were conducted for each subtype. The relationships between the PD subtypes and polygenic risk scores (PRS) for MDD, a psychiatric disorder, and premenstrual syndrome (PMS), a hormonal disorder, were examined. Among 12,338 participants, 1,145 (9.3%) developed pregnancy PD, 856 (6.9%) developed early postpartum PD, 382 (3.1%) developed late postpartum PD, and 1,048 (8.5%) developed chronic PD. Depressive symptoms decreased to 61.0%–73.3% in the 5 years postpartum. The relationship between risk factors and PD varied based on the PD subtype. Additionally, chronic PD increased the risk of child behavior problems by 2- to 3-fold. The GWASs uncovered five significant variants in different loci depending on PD subtypes, suggesting a subtype-specific genetic architecture. The PRS for MDD was related to pregnancy, early postpartum, and chronic PD, while that for PMS was related to late postpartum PD. It was concluded that PD is heterogeneous depending on the depressive symptom trajectory. Thus, specific prevention and treatment strategies are needed.
Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. 国際誌

Satoshi Mizuno, Maiko Wagata, Satoshi Nagaie, Mami Ishikuro, Taku Obara, Gen Tamiya, Shinichi Kuriyama, Hiroshi Tanaka, Nobuo Yaegashi, Masayuki Yamamoto, Junichi Sugawara, Soichi Ogishima

Scientific reports　14　(1)　6292-6292　2024年3月15日

DOI： 10.1038/s41598-024-55914-9 　

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Recently, many phenotyping algorithms for high-throughput cohort identification have been developed. Prospective genome cohort studies are critical resources for precision medicine, but there are many hurdles in the precise cohort identification. Consequently, it is important to develop phenotyping algorithms for cohort data collection. Hypertensive disorders of pregnancy (HDP) is a leading cause of maternal morbidity and mortality. In this study, we developed, applied, and validated rule-based phenotyping algorithms of HDP. Two phenotyping algorithms, algorithms 1 and 2, were developed according to American and Japanese guidelines, and applied into 22,452 pregnant women in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank project. To precise cohort identification, we analyzed both structured data (e.g., laboratory and physiological tests) and unstructured clinical notes. The identified subtypes of HDP were validated against reference standards. Algorithms 1 and 2 identified 7.93% and 8.08% of the subjects as having HDP, respectively, along with their HDP subtypes. Our algorithms were high performing with high positive predictive values (0.96 and 0.90 for algorithms 1 and 2, respectively). Overcoming the hurdle of precise cohort identification from large-scale cohort data collection, we achieved both developed and implemented phenotyping algorithms, and precisely identified HDP patients and their subtypes from large-scale cohort data collection.
Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Geng Chen, Mami Ishikuro, Hisashi Ohseto, Keiko Murakami, Aoi Noda, Genki Shinoda, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

Acta obstetricia et gynecologica Scandinavica　2024年3月7日

DOI： 10.1111/aogs.14820 　

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INTRODUCTION: Developmental delay at an early age indicates the probability of continued problems after school age. Hypertensive disorders of pregnancy (HDP) are associated with developmental delays in offspring, with inconsistent outcomes. Neonatal outcomes vary according to HDP exposure and are relevant to development in later years. Here we aimed to clarify the relationship between HDP and developmental delay in offspring and whether neonatal outcomes mediate this association. MATERIAL AND METHODS: We used data from 5934 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study conducted in Japan between July 2013 and March 2017. The Ages and Stages Questionnaires, third edition, at 24 and 42 months of age, measured developmental delay in five areas. We performed multivariate quasi-Poisson regression and causal mediation analysis by neonatal outcomes. RESULTS: At 24 months of age, compared to offspring born from normotensive mothers, offspring born from HDP-affected mothers were more likely to experience developmental delay (risk ratio [RR] 1.29, 95% confidence interval [CI]: 1.09-1.52) in the areas of communication (RR 1.21, 95% CI: 1.00-1.45) and personal-social (RR 1.15, 95% CI: 1.03-1.28). This association was mediated by neonatal outcomes: preterm birth, neonatal asphyxia, NICU admission, and neonatal small head circumference. No association was observed between HDP and developmental delay at 42 months of age. CONCLUSIONS: Exposure to HDP during fetal life is associated with offspring developmental delay. This association is partly mediated by neonatal outcomes.
Role of Genetic Risk in the Association Between Screen Time and Child Development. 国際誌

Ippei Takahashi, Taku Obara, Shinichi Kuriyama

JAMA pediatrics　178　(3)　317-318　2024年3月1日

DOI： 10.1001/jamapediatrics.2023.6106 　
血圧コントロール不良に対する不十分な高血圧薬物治療による影響リアルワールドデータに基づく解析日本循環器病予防学会予防医学賞を受賞して

佐藤倫広, 室谷智子, 村上任尚, 小原拓, 浅山敬, 大久保孝義, 今井潤, 目時弘仁

日本循環器病予防学会誌　59　(1)　50-54　2024年3月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. 国際誌

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Atsushi Shimizu, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2024年2月29日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-024-01582-1 　

ISSN：0916-9636

eISSN：1348-4214

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Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 men and 38,921 women aged ≥20 years). A model adjusted for age, body mass index, smoking status, drinking status, estimated daily salt intake, potassium excretion, (or urinary sodium-to-potassium ratio), gamma-glutamyl transferase, physical activity, education level, status of damage to homes during the Great East Japan Earthquake, and residential areas was used. The average age and systolic blood pressure were 62.5 (10.3) years for men and 59.6 (11.3) years for women, 128.9 (16.7) mmHg for men and 124.7 (17.5) mmHg for women, respectively. Body mass index estimated daily salt intake, urinary sodium-to-potassium ratio and gamma-glutamyl transferase levels were positively associated with systolic blood pressure. Compared with never-drinkers, current drinkers who consumed 23–45 g/day and ≥46.0 g/day had significantly increased systolic blood pressure. Conversely, current smokers (1-10 cigarettes/day and 11-20 cigarettes/day) were inversely associated with systolic blood pressure compared to never-smokers. Overall, systolic blood pressure was associated with gamma-glutamyl transferase and hypertension risk factors, including body mass index, alcohol consumption, estimated daily salt intake, urinary sodium-to-potassium ratio, and potassium excretion. Our findings support the notion that lifestyle modifications should be attempted to prevent hypertension.
Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

Journal of epidemiology　2024年2月24日

DOI： 10.2188/jea.JE20230241 　

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BACKGROUND: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. METHODS: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). RESULTS: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. CONCLUSIONS: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.
Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

Journal of diabetes investigation　2024年2月23日

DOI： 10.1111/jdi.14159 　

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AIMS: This study aimed to investigate the association of maternal birth weight (MBW) with early and late gestational diabetes mellitus (GDM). METHODS: A total of 69318 pregnant Japanese women were included in this birth cohort study. The associations between maternal birth weight and early gestational diabetes mellitus (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were investigated using a multinomial logistic regression model, with an maternal birth weight of 3000-3499 g as the reference category. RESULTS: Lower maternal birth weight was associated with higher odds of developing early and late gestational diabetes mellitus (P < 0.0001 and P < 0.0001, respectively). The adjusted odds ratios (aORs) for early gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were 1.345 (95% confidence interval [CI]: 0.912-1.984) and 1.338 (95% CI: 1.098-1.629), respectively. The aORs for late gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were, 1.657 (95% CI: 1.298-2.115) and 1.218 (95% CI: 1.058-1.402), respectively. CONCLUSIONS: Regardless of the gestational age when gestational diabetes mellitus was diagnosed, a lower maternal birth weight was associated with an increased risk of gestational diabetes mellitus. Furthermore, the association of a MBW <2500 g with late gestational diabetes mellitus tended to be stronger than that with early gestational diabetes mellitus.
Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　2024年2月6日

DOI： 10.5551/jat.64535 　

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AIMS: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. METHODS: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C ≥ 140 mg/dL and/or dyslipidemia treatment. Multivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. RESULTS: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. CONCLUSIONS: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.
添付文書で妊婦に対して禁忌に設定されている医薬品の特定と国際比較

酒井隆全, 佐藤ユリ, 畠山史朗, 菊池大輔, 土屋雅美, 近藤悠希, 佐藤泉美, 岡田裕子, 小原拓

医薬品情報学　25　(4)　211-219　2024年2月
出版者・発行元： (一社)日本医薬品情報学会
ISSN：1345-1464

eISSN：1883-423X
Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children’s Study

Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Masatoshi Saito, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Nutrients　16　(4)　2024年2月

DOI： 10.3390/nu16040531 　

eISSN：2072-6643
The impact of maternal and paternal birth weights on infant birth weights: the Japan environment and children's study. 国際誌

Hasumi Tomita, Noriyuki Iwama, Hirotaka Hamada, Rie Kudo, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Journal of developmental origins of health and disease　1-12　2024年1月22日

DOI： 10.1017/S2040174423000387 　

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This study aimed to evaluate the association between parental and infant birth weights in Japan. In total, 37,504 pregnant Japanese women and their partners were included in this birth cohort study. A multinomial logistic regression model was used to evaluate the associations of parental birth weights with small-for-gestational-age (SGA) or large-for-gestational-age (LGA) infants. Associations between parental birth weight and low birth weight (LBW) infants or macrosomia were also examined, and linear associations between parental birth weight and SGA or LGA were found. The adjusted odds ratios (aORs) for SGA infants per 500 g decrease in maternal and paternal birth weights were 1.50 (95% confidence interval [CI],1.43-1.58) and 1.31 (95% CI, 1.25-1.38), respectively. The aORs for LGA infants per 500 g increase in maternal and paternal birth weights were 1.53 (95% CI, 1.47-1.60) and 1.41 (95% CI, 1.35-1.47), respectively. The association between parental birth weight and LBW infants or macrosomia was also linear. The aORs for LBW infants per 500 g decrease in maternal and paternal birth weights were 1.47 (95% CI, 1.40-1.55) and 1.25 (95% CI, 1.19-1.31), respectively. The aORs for macrosomia per 500 g increase in maternal and paternal birth weights were 1.59 (95% CI, 1.41-1.79) and 1.40 (95% CI, 1.23-1.60), respectively. Parental birth weight was found to be associated with infant birth weight even after adjusting for various parental factors. Furthermore, maternal birth weight was more strongly associated with infant birth weight than with paternal birth weight.
Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. 国際誌

Aoi Noda, Taku Obara, Fumiko Matsuzaki, Satoko Suzuki, Ryutaro Arita, Minoru Ohsawa, Ryo Obara, Kei Morishita, Fumihiko Ueno, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Hiroshi Kawame, Shigeo Kure, Shinichi Kuriyama

Drugs - real world outcomes　2024年1月19日

DOI： 10.1007/s40801-023-00411-0 　

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BACKGROUND: Japanese traditional (Kampo) medicines containing ephedra may be used to treat colds during pregnancy. There are reports that ephedrine, a component of ephedra, has a risk of teratogenicity; however, the evidence remains equivocal. OBJECTIVE: This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with exposure to Kampo medicines containing ephedra during the first trimester of pregnancy using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: To 23,730 mother-infant pairs who participated in the TMM BirThree Cohort Study from July 2013 to March 2017, questionnaires in early and middle pregnancy were distributed approximately at weeks 12 and 26 of pregnancy, respectively. Infants' risk of MCMs in women who used Kampo medicines containing ephedra or acetaminophen during the first trimester was assessed, and the odds ratios (ORs) were estimated with unadjusted and adjusted analyses. RESULTS: Among 20,879 women, acetaminophen and Kampo medicines containing ephedra were used in 665 (3.19%) and 376 (1.80%) women, respectively, in the first trimester. Among the infants born to the mothers who used acetaminophen or Kampo medicine containing ephedra during the first trimester, 11 (1.65%) and 8 (2.13%), respectively, had overall MCMs. OR of overall MCMs was higher in women who used Kampo medicines containing ephedra than in those who used acetaminophen in the first trimester (adjusted OR, 1.45; 95% confidence interval (CIs), 0.57-3.71); however, the difference was not statistically significant. CONCLUSIONS: In this study, there was no statistically significant association between the use of Kampo medicines containing ephedra during the first trimester of pregnancy and the risk of MCMs. Although some point estimates of ORs exceeded 1.00, the absolute magnitude of any increased risks would be low.
Trends in Anti-Influenza Drug Prescription and Adverse Drug Reaction Reporting After the Lifting of Oseltamivir Prescribing Restrictions in Pediatric Outpatients: An Ecological Study Using the MDV Analyzer® And the Japanese Adverse Drug Event Report Database

Misaki Tokunaga, Daisuke Kikuchi, Aoi Noda, Sachiko Oikawa, Makoto Shiozawa, Hiroaki Hino, Ryosuke Miura, Kensuke Usui, Taku Obara, Kouji Okada

Drugs - Real World Outcomes　2024年1月18日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s40801-023-00414-x 　

ISSN：2199-1154

eISSN：2198-9788
Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis. 国際誌

Mami Ishikuro, Tomoko Nishimura, Hiroyoshi Iwata, Hirohito Metoki, Taku Obara, Noriyuki Iwama, Keiko Murakami, Md Shafiur Rahman, Maki Tojo, Sumitaka Kobayashi, Chihiro Miyashita, Keiko Tanaka, Yoshihiro Miyake, Kazue Ishitsuka, Reiko Horikawa, Naho Morisaki, Midori Yamamoto, Kenichi Sakurai, Chisato Mori, Atsushi Shimizu, Fumihiro Sata, Kenji J Tsuchiya, Reiko Kishi, Shinichi Kuriyama

Journal of human hypertension　2024年1月10日

DOI： 10.1038/s41371-023-00890-2 　
Evaluation of hospital pharmacists’ activities using additional reimbursement for infection prevention as an indicator in small and medium-sized hospitals

Yuichi Tasaka, Takeshi Uchikura, Shiro Hatakeyama, Daisuke Kikuchi, Masami Tsuchiya, Ryohkan Funakoshi, Taku Obara

Journal of Pharmaceutical Health Care and Sciences　10　(1)　2024年1月10日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/s40780-023-00327-5 　

eISSN：2055-0294

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Abstract Background Hospitals in Japan established the healthcare delivery system from FY 2018 to 2021 by acquiring an additional reimbursement for infection prevention (ARIP) of category 1 or 2. However, research on outcomes of ARIP applications related to the practice of hospital pharmacists is scarce. Methods This study assessed the activities performed by hospital pharmacists in hospitals with 100 to 299 beds, using ARIP acquirement as an indicator, using data from an annual questionnaire survey conducted in 2020 by the Japanese Society of Hospital Pharmacists on the status of hospital pharmacy departments. Out of the survey items, this study used those related to hospital functions, number of beds, number of pharmacists, whether the hospital is included in the diagnosis procedure combination (DPC) system, average length of stay, and nature of work being performed in the analysis. The relationship between the number of beds per pharmacist and state of implementation of pharmacist services or the average length of hospital stay was considered uncorrelated when the absolute value of the correlation coefficient was within 0–0.2, whereas the relationship was considered to have a weak, moderate, or strong correlation when the absolute value ranged at 0.2–0.4, 0.4–0.7, or 0.7–1, respectively. Results Responses were received from 3612 (recovery rate: 43.6%) hospitals. Of these, 210 hospitals meeting the criteria for ARIP 1 with 100–299 beds, and 245 hospitals meeting the criteria for ARIP 2 with 100–299 beds, were included in our analysis. There was a significant difference in the number of pharmacists, with a larger number in ARIP 1 hospitals. For the pharmacist services, significant differences were observed, with a more frequency in ARIP 1 hospitals in pharmaceutical management and guidance to pre-hospitalization patients, sterile drug processing of injection drugs and therapeutic drug monitoring. In DPC hospitals with ARIP 1 (173 hospitals) and 2 (105 hospitals), the average number of beds per pharmacist was 21.7 and 24.7, respectively, while the average length of stay was 14.3 and 15.4 d, respectively. Additionally, a weak negative correlation was observed between the number of pharmacist services with “Fairly well” or “Often” and the number of beds per pharmacist for both ARIP 1 (R = -0.207) and ARIP 2 (R = -0.279) DPC hospitals. Furthermore, a weak correlation (R = 0.322) between the average number of beds per pharmacist and the average length of hospital stay was observed for ARIP 2 hospitals. Conclusions Our results suggest that lower beds per pharmacist might lead to improved pharmacist services in 100–299 beds DPC hospitals with ARIP 1 or 2. The promotion of proactive efforts in hospital pharmacist services and fewer beds per pharmacist may relate to shorter hospital stays especially in small and medium-sized hospitals with ARIP 2 when ARIP acquisition was used as an indicator. These findings may help to accelerate the involvement of hospital pharmacists in infection control in the future.
尿中Na、K、Na/K比と胃がん罹患との関連東北メディカル・メガバンク計画地域住民コホート調査

小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 小原拓, 永家聖, 布施昇男, 泉陽子, 栗山進一, 中谷直樹, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　100-100　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画地域住民コホート調査(宮城) これまでの進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 石黒真美, 大類真嗣, 野田あおい, 篠田元気, 小原拓, 宇留野晃, 布施昇男, 泉陽子, 栗山進一, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　133-133　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
ToMMo地域住民コホート調査におけるPreserved ratio impairment spirometryの有病と関連する要因の検討

岩崎史, 中谷久美, 山田充啓, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 石黒真美, 大類真嗣, 永家聖, 中村智洋, 荻島創一, 布施昇男, 泉陽子, 栗山進一, 杉浦久敏, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　139-139　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Alcohol Flushingと悪性腫瘍有病の関連 TMM計画地域住民コホート調査(宮城)

土谷祐馬, 中谷久美, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 石黒真美, 大類正嗣, 永家聖, 中村智洋, 荻島創一, 布施昇男, 泉陽子, 栗山進一, 亀井尚, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　154-154　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
産後うつ・自殺問題の縦断的リスクと関連要因の検討東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 岩間憲之, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 目時弘仁, 菊谷昌浩, 中谷直樹, 寳澤篤, 栗山進一

Journal of Epidemiology　34　(Suppl.)　158-158　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
震災による自宅損壊および心的外傷後ストレス反応と修正可能な認知症の危険因子の関連

千葉一平, 小暮真奈, 中谷久美, 畑中里衣子, 小原拓, 丹野高三, 栗山進一, 中谷直樹, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　174-174　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Temporal trends in antipsychotic prescriptions for pediatric patients using an administrative hospital database in Japan: a retrospective study 査読有り

Daisuke Kikuchi, Taku Obara, Ryo Obara, Hiroaki Hino, Naoto Suzuki, Shota Kashiwagura, Takashi Watanabe, Ryusuke Ouchi, Kensuke Usui, Kouji Okada

Journal of Pharmaceutical Health Care and Sciences　10　2024年1月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/s40780-023-00324-8 　

eISSN：2055-0294

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Abstract Background Schizophrenia is a psychiatric disorder characterized by hallucinations, delusions, and other symptoms. Although treatment guidelines for schizophrenia have been established in Japan, drugs are not recommended for pediatric schizophrenia. Additionally, the temporal trends in prescribing antipsychotics for pediatric patients with schizophrenia are unclear. Therefore, we aimed to clarify the trends in antipsychotic prescriptions for Japanese pediatric outpatients from 2015 to 2022. Methods Administrative data (as of November 2023) of Japanese pediatric outpatients with schizophrenia aged 0–18 years who visited acute-care diagnosis procedure combination hospitals between January 1, 2015, and December 31, 2022, were included in this study. The target drugs for schizophrenia were all indicated for treating schizophrenia and marketed in Japan as of December 2022. Annual prescription trends for antipsychotics during this period were calculated based on their proportions. The Cochran–Armitage trend test was used to evaluate the proportion of prescriptions for each antipsychotic. Results The main drugs prescribed for these patients were aripiprazole and risperidone. Among male patients, the proportion of prescriptions for aripiprazole increased significantly from 21.2% in 2015 to 35.9% in 2022, whereas that for risperidone decreased significantly from 47.9% in 2015 to 36.7% in 2022 (both P < 0.001). Among female patients, the proportion of prescriptions for aripiprazole increased significantly from 21.6% in 2015 to 35.6% in 2022, whereas that for risperidone decreased significantly from 38.6% in 2015 to 24.8% in 2022 (both P < 0.001). Conclusions Aripiprazole and risperidone were primarily prescribed for pediatric schizophrenia in Japan during the study period. Additionally, the proportion of aripiprazole prescriptions increased over time.
Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Misato Aizawa, Keiko Murakami, Ippei Takahashi, Hisashi Ohseto, Aoi Noda, Genki Shinoda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama

Nutrition journal　22　(1)　66-66　2023年12月6日

DOI： 10.1186/s12937-023-00901-5 　

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BACKGROUND: Although an association between maternal nutritional intake and developmental delays in children has been demonstrated, the association of the timing of meal intake and development delays remains unclear. We examined the association between breakfast intake frequency before and during pregnancy and developmental delay in children. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 7491 answered the required questions and were analyzed. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: daily, and 5-6, 3-4, and 0-2 times/week. Child developmental delays at age 2 and 3.5 years were assessed using the Ages & Stages Questionnaire, Third Edition. Logistic regression models were constructed to examine the association between breakfast intake frequency in pregnant women and developmental delays in children aged 2 and 3.5 years. RESULTS: The proportion of pregnant women who had breakfast daily was 78.1% in pre- to early pregnancy, and 82.2% in early to mid-pregnancy. The proportion of children with developmental delays was 14.7% and 13.4% at age 2 and 3.5 years, respectively. Compared with the risk in children of women who had breakfast daily from pre- to early pregnancy, children of women who had breakfast 0-2 times/week had a higher risk of developmental delays at 2 years of age: odds ratio (OR) 1.30, (95% confidence interval [CI], 1.02-1.66). The risk of developmental delays at age 2 years increased in the children of women who had breakfast 0-2 times/week in early to mid- pregnancy: OR 1.75 (95% CI, 1.32-2.32). The risk of developmental delays at age 3.5 years did not increase in the children of women who had breakfast 0-2 times/week from pre- to early and early to mid-pregnancy: OR 1.06 (95% CI, 0.81-1.39 and OR 1.15 (95% CI 0.84-1.57), respectively. CONCLUSION: For women with a low frequency of breakfast intake from pre- to mid-pregnancy there was an association with developmental delays in their children at age 2, but not at 3.5 years.
Maternal birth weight as an indicator of early-onset and late-onset hypertensive disorders of pregnancy: The Japan Environment and Children's study. 国際誌

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Pregnancy hypertension　34　159-168　2023年11月21日

DOI： 10.1016/j.preghy.2023.11.002 　

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OBJECTIVES: This study aimed to investigate the association between maternal birth weight (MBW) and hypertensive disorders of pregnancy (HDP) according to the gestational age when HDP develops. STUDY DESIGN: A total of 77,345 subjects were included in this prospective birth cohort study. The association between MBW and HDP was investigated by a multinomial logistic regression model. MAIN OUTCOME MEASURES: Early-onset HDP (EO-HDP), preterm late-onset HDP (preterm LO-HDP), and term late-onset HDP (term LO-HDP). RESULTS: Lower MBW was associated with higher odds of preterm and term LO-HDP (p-values for trend < 0.0001 and = 0.0005, respectively). A linear association between MBW and EO-HDP was observed (p-values for trend = 0.0496). The shape of the association between MBW and preterm LO-HDP was a combination of the associations between MBW with EO-HDP or LO-HDP. The effect size of the association between MBW < 2,500 g and EO-HDP was lower than that of MBW < 2,500 g with preterm or term LO-HDP. The adjusted odds ratios for EO-HDP, preterm LO-HDP, and term LO-HDP in subjects with MBW < 2,500 g were 1.052 (95 % confidence interval [CI]: 0.665-1.664), 1.745 (95 % CI: 1.220-2.496), and 1.496 (95 % CI: 1.154-1.939), respectively. CONCLUSIONS: MBW was associated with HDP, regardless of gestational age when HDP developed. Furthermore, the association of MBW < 2,500 g with preterm or term LO-HDP was stronger than that with EO-HDP.
The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. 国際誌

Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2023年10月31日

DOI： 10.1038/s41440-023-01484-8 　

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Masked hypertension is a risk factor for cardiovascular diseases. However, masked hypertension is sometimes overlooked owing to the requirement for home blood pressure measurements for diagnosing. Mental status influences blood pressure. To reduce undiagnosed masked hypertension, this study assessed the association between depressive symptoms and masked hypertension. This cross-sectional study used data from the Tohoku Medical Megabank Project Community-Based Cohort Study (conducted in Miyagi Prefecture, Japan, from 2013) and included participants with normotension measured at the research center (systolic blood pressure<140 mmHg and diastolic blood pressure <90 mmHg). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (Japanese version). Masked hypertension was defined as normotension measured at the research center and home hypertension (home systolic blood pressure ≥135 mmHg or home diastolic blood pressure ≥85 mmHg). The study comprised 6705 participants (mean age: 55.7 ± 13.7 years). Of these participants, 1106 (22.1%) without depressive symptoms and 393 (23.2%) with depressive symptoms were categorized to have masked hypertension. Sex-specific and age-adjusted least mean squares for home blood pressure, not for research blood pressure were significantly higher in the group with depressive symptoms in both sex categories. The multivariate odds ratio for masked hypertension in the patients with depressive symptoms was 1.72 (95% confidence interval: 1.26-2.34) in male participants and 1.30 (95% confidence interval: 1.06-1.59) in female ones. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at the research center. Depressive symptoms may be one of the risk factors for masked hypertension. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.
The impact of clinical inertia on uncontrolled blood pressure in treated hypertension: real-world, longitudinal data from Japan. 国際誌

Michihiro Satoh, Tomoko Muroya, Takahisa Murakami, Taku Obara, Kei Asayama, Takayoshi Ohkubo, Yutaka Imai, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　2023年10月23日

DOI： 10.1038/s41440-023-01452-2 　

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We aimed to quantify the impact of inadequate pharmacological therapy on uncontrolled blood pressure (BP) using Japanese real-world data. This retrospective cohort study used databases provided by DeSC Healthcare, Inc (Tokyo, Japan). We identified 27,652 patients with hypertension (age, 60.7 ± 9.1 years; men, 56.4%) who were not receiving antihypertensive treatment at the initial visit (pre-treatment) and were under treatment at the next visit (post-treatment). Patients were classified into the following groups by the number of antihypertensive drug classes and defined daily dose (DDD): one antihypertensive drug class with a low dose (DDD < 1.0), one antihypertensive drug class with a moderate-to-high dose (DDD ≥ 1.0), two antihypertensive drug classes with a low dose (DDD < 2.0), two antihypertensive drug classes with a moderate-to-high dose (DDD ≥ 2.0), and ≥three antihypertensive drug classes. The pre-treatment systolic/diastolic BP was 157.7 ± 15.4/94.2 ± 11.5 mmHg. Overall, 43.0% of patients had uncontrolled BP (post-treatment BP ≥ 140/ ≥ 90 mmHg). High pre-treatment BP was a strong factor for uncontrolled BP. After adjustments for covariates, including the pre-treatment mean BP, the proportion of patients with uncontrolled BP was 2.08 times higher in the one antihypertensive drug class with a low dose group than in the ≥three antihypertensive drug classes group. The preventable fraction due to <three antihypertensive drug classes for uncontrolled BP was 40.6%. Only 9.9% of patients with the pre-treatment BP ≥ 180/ ≥ 110 mmHg were prescribed ≥ three antihypertensive drug classes. High pre-treatment BP and inadequate antihypertensive treatment were major factors contributing to uncontrolled BP. Adequate treatment intensification would resolve approximately 40% of uncontrolled BP cases among Japanese patients treated for hypertension. 27,652 Japanese patients treated with antihypertensive medications.
The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study

Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Hideaki Hashimoto, Tomohiro Nakamura, Kotaro Nochioka, Taku Obara, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Akira Uruno, Eiichi N. Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension Research　2023年10月13日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-023-01454-0 　

ISSN：0916-9636

eISSN：1348-4214

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Abstract This study aimed to examine whether risk of withdrawal from HTTx was higher in coastal areas that were severely damaged by tsunami than in inland areas. We conducted a cross-sectional study of 9218 participants aged ≥20 years in Miyagi, Japan. The odds ratios (ORs) and confidence interval (CI) for withdrawal from HTTx in coastal and inland groups were compared using multivariate logistic regression analysis, adjusting for potential confounders. In total, 194 of 5860 and 146 of 3358 participants in the inland and coastal groups, respectively, withdrew from HTTx treatment. OR (95%CI) of withdrawal from HTTx in the coastal group was 1.46 (1.14–1.86) compared to the inland group. According to housing damage, ORs (95% CI) in the no damage, partially destroyed, and more than half destroyed coastal groups compared with the no damage inland group were 1.62 (1.04–2.50), 1.69 (1.17–2.45), and 1.08 (0.71–1.65), respectively. In conclusion, the risk of HTTx withdrawal for participants whose homes in coastal areas were relatively less damaged was significantly higher compared with those in inland areas, while the risk of HTTx withdrawal for participants whose homes were more than half destroyed was not. Post-disaster administrative support for disaster victims is considered vital for continuation of their treatment.
Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Journal of atherosclerosis and thrombosis　2023年10月6日

DOI： 10.5551/jat.64425 　

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AIM: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. METHODS: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. RESULTS: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92-7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73-6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65-3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. CONCLUSIONS: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.
向精神薬服用中の母乳育児の実態と児への影響授乳プランシートの結果から

菊地紗耶, 小林奈津子, 小原拓, 岩渕理子, 齋藤昌利, 木村涼子, 岩渕賢嗣, 富田博秋

日本周産期メンタルヘルス学会学術集会抄録集　19回　114-114　2023年10月
出版者・発行元：日本周産期メンタルヘルス学会
東北メディカル・メガバンク計画三世代コホート調査これまでの進捗

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寶澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　370-370　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
東北メディカル・メガバンク計画三世代コホート調査における追加リクルート

石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　370-370　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
コホート調査データの連係・活用推進のための基盤整備マイToMMoの開発と実装

野田あおい, 篠田元気, 石黒真美, 千葉一平, 大類真嗣, 村上慶子, 小原拓, 菅野郁美, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　371-371　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
東北メディカル・メガバンク計画地域住民コホート調査(宮城) これまでの進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 石黒真美, 大類真嗣, 野田あおい, 篠田元気, 村上慶子, 小原拓, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　82回　398-398　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
Real-world prevalence, time of diagnosis, and co-occurrence patterns of birth defects in live-born infants, 2014-2020: A health administrative database study in Japan. 国際誌

Tomofumi Ishikawa, Hiroshi Kawame, Nariyasu Mano, Taku Obara

Birth defects research　115　(18)　1723-1736　2023年9月8日

DOI： 10.1002/bdr2.2247 　

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BACKGROUND: A study evaluating the real-world prevalence of birth defects (BDs), including co-occurrence patterns, will provide the information required to estimate Japan's true BD prevalence and monitor it. Information such as when infants are diagnosed with BDs is crucial for defining the study population and data collection period in future administrative database studies. METHODS: This study utilized the DeSC database, a large claims database comprising multiple health insurance schemes. The prevalence of major BDs, including structural congenital malformations (CMs) and chromosomal abnormalities, was determined in infants born between 2014 and 2020 and continuously insured for ≥1 year. The time of the first BD diagnosis and multiple BD patterns were also evaluated. RESULTS: Among 43,147 infants, 3050 (7.07%) were diagnosed with major BDs, and 3002 (6.96%) with major CMs. The circulatory system (2.95%) was the most frequent organ system affected by CMs, followed by CMs and deformations of the musculoskeletal system (1.94%). The cumulative diagnostic rates of BDs and CMs at month 6 were 85.9% and 85.6%, respectively. The EUROCAT BD subgroups diagnosed in more than 1.0% of the infants were atrial septal defects (1.47%) and patent ductus arteriosus (1.07%). Among the 2997 infants with EUROCAT BDs, 241 (8.04%) were classified as having multiple BDs. CONCLUSIONS: A large claims database is a valuable resource for evaluating and monitoring the prevalence of BDs, including multiple patterns. At least 1 year since birth should be considered in future administrative database studies evaluating BDs as outcomes.
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　261-261　2023年9月
出版者・発行元： (NPO)日本高血圧学会
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　358-358　2023年9月
出版者・発行元： (NPO)日本高血圧学会
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　261-261　2023年9月
出版者・発行元： (NPO)日本高血圧学会
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　358-358　2023年9月
出版者・発行元： (NPO)日本高血圧学会
Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. 国際誌

Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama, Taku Obara, Mami Ishikuro, Hiroshi Tanaka, Kengo Kinoshita, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Soichi Ogishima

BMC pregnancy and childbirth　23　(1)　628-628　2023年8月31日

DOI： 10.1186/s12884-023-05919-5 　

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BACKGROUND: Low birth weight (LBW) is a leading cause of neonatal morbidity and mortality, and increases various disease risks across life stages. Prediction models of LBW have been developed before, but have limitations including small sample sizes, absence of genetic factors and no stratification of neonate into preterm and term birth groups. In this study, we challenged the development of early prediction models of LBW based on environmental and genetic factors in preterm and term birth groups, and clarified influential variables for LBW prediction. METHODS: We selected 22,711 neonates, their 21,581 mothers and 8,593 fathers from the Tohoku Medical Megabank Project Birth and Three-Generation cohort study. To establish early prediction models of LBW for preterm birth and term birth groups, we trained AI-based models using genetic and environmental factors of lifestyles. We then clarified influential environmental and genetic factors for predicting LBW in the term and preterm groups. RESULTS: We identified 2,327 (10.22%) LBW neonates consisting of 1,077 preterm births and 1,248 term births. Our early prediction models archived the area under curve 0.96 and 0.95 for term LBW and preterm LBW models, respectively. We revealed that environmental factors regarding eating habits and genetic features related to fetal growth were influential for predicting LBW in the term LBW model. On the other hand, we identified that genomic features related to toll-like receptor regulations and infection reactions are influential genetic factors for prediction in the preterm LBW model. CONCLUSIONS: We developed precise early prediction models of LBW based on lifestyle factors in the term birth group and genetic factors in the preterm birth group. Because of its accuracy and generalisability, our prediction model could contribute to risk assessment of LBW in the early stage of pregnancy and control LBW risk in the term birth group. Our prediction model could also contribute to precise prediction of LBW based on genetic factors in the preterm birth group. We then identified parental genetic and maternal environmental factors during pregnancy influencing LBW prediction, which are major targets for understanding the LBW to address serious burdens on newborns' health throughout life.
Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 Years. 国際誌

Ippei Takahashi, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Tomoko Nishimura, Kenji J Tsuchiya, Shinichi Kuriyama

JAMA pediatrics　2023年8月21日

DOI： 10.1001/jamapediatrics.2023.3057 　

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IMPORTANCE: Whether some domains of child development are specifically associated with screen time and whether the association continues with age remain unknown. OBJECTIVE: To examine the association between screen time exposure among children aged 1 year and 5 domains of developmental delay (communication, gross motor, fine motor, problem-solving, and personal and social skills) at age 2 and 4 years. DESIGN, PARTICIPANTS, AND SETTING: This cohort study was conducted under the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Pregnant women at 50 obstetric clinics and hospitals in the Miyagi and Iwate prefectures in Japan were recruited into the study between July 2013 and March 2017. The information was collected prospectively, and 7097 mother-child pairs were included in the analysis. Data analysis was performed on March 20, 2023. EXPOSURE: Four categories of screen time exposure were identified for children aged 1 year (<1, 1 to <2, 2 to <4, or ≥4 h/d). MAIN OUTCOMES AND MEASURES: Developmental delays in the 5 domains for children aged 2 and 4 years were assessed using the Japanese version of the Ages & Stages Questionnaires, Third Edition. Each domain ranged from 0 to 60 points. Developmental delay was defined if the total score for each domain was less than 2 SDs from its mean score. RESULTS: Of the 7097 children in this study, 3674 were boys (51.8%) and 3423 were girls (48.2%). With regard to screen time exposure per day, 3440 children (48.5%) had less than 1 hour, 2095 (29.5%) had 1 to less than 2 hours, 1272 (17.9%) had 2 to less than 4 hours, and 290 (4.1%) had 4 or more hours. Children's screen time was associated with a higher risk of developmental delay at age 2 years in the communication (odds ratio [OR], 1.61 [95% CI, 1.23-2.10] for 1 to <2 h/d; 2.04 [1.52-2.74] for 2 to <4 h/d; 4.78 [3.24-7.06] for ≥4 vs <1 h/d), fine motor (1.74 [1.09-2.79] for ≥4 vs <1 h/d), problem-solving (1.40 [1.02-1.92] for 2 to <4 h/d; 2.67 [1.72-4.14] for ≥4 vs <1 h/d), and personal and social skills (2.10 [1.39-3.18] for ≥4 vs <1 h/d) domains. Regarding risk of developmental delay at age 4 years, associations were identified in the communication (OR, 1.64 [95% CI, 1.20-2.25] for 2 to <4 h/d; 2.68 [1.68-4.27] for ≥4 vs <1 h/d) and problem-solving (1.91 [1.17-3.14] for ≥4 vs <1 h/d) domains. CONCLUSIONS AND RELEVANCE: In this study, greater screen time for children aged 1 year was associated with developmental delays in communication and problem-solving at ages 2 and 4 years. These findings suggest that domains of developmental delay should be considered separately in future discussions on screen time and child development.
新生児臍帯血の網羅的エピゲノム解析による妊娠初期までの喫煙経験が次世代に及ぼす影響

美辺詩織, 小巻翔平, 大桃秀樹, 高嶋聰, 小野加奈子, 山崎弥生, 須藤洋一, 田高周, 水野聖士, 石黒真美, 工藤久智, 小原拓, 熊田和貴, 勝岡史城, 荻島創一, 木下賢吾, 菅原準一, 栗山進一, 清水厚志

DOHaD研究　11　(3)　37-37　2023年8月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
母親の妊娠中と産後の心理的苦痛と4歳時点における児の発達との関連三世代コホート調査

高橋一平, 小原拓, 菊地紗耶, 小林美佳, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 小林奈津子, 濱田裕貴, 岩間憲之, 齋藤昌利, 菅原準一, 富田博秋, 呉繁夫, 八重樫伸生, 栗山進一

DOHaD研究　11　(3)　29-29　2023年8月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
妊娠初期の消化管運動改善薬の大奇形リスク大規模レセプトデータベースを用いた評価

小原拓, 石川智史, 赤沢学, 野田あおい, 大柳元, 森下啓, 都田桂子, 西郡秀和, 川目裕, 八重樫伸生, 栗山進一, 眞野成康

DOHaD研究　11　(3)　38-39　2023年8月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
Efficacy of exponentiation method with a convolutional neural network for classifying lung nodules on CT images by malignancy level

Takuma Usuzaki, Kengo Takahashi, Hidenobu Takagi, Mami Ishikuro, Taku Obara, Takumi Yamaura, Masahiro Kamimoto, Kazuhiro Majima

European Radiology　Epub ahead of print　2023年7月21日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s00330-023-09946-w 　

eISSN：1432-1084
Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.

Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

JMA journal　6　(3)　246-264　2023年7月14日

DOI： 10.31662/jmaj.2022-0220 　

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The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment.
Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.

Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Masato Takase, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Taku Obara, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Junichi Sugawara, Eiichi N Kodama, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　2023年7月5日

DOI： 10.5551/jat.64151 　

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AIM: People with high normal blood pressure (BP) have a higher risk of cardiovascular events than those with normal BP; therefore, progression to hypertension (HT) should be prevented. We aimed to assess the HT risk using central BP and carotid intima media thickness (CIMT) in people with high normal BP. METHODS: This prospective cohort study used the Tohoku Medical Megabank Community-Based Project Cohort Study (conducted from 2013 in Miyagi Prefecture in Japan). The participants had a high normal BP, defined as a systolic BP of 120-139 mmHg and diastolic BP ＜90 mmHg using brachial BP measurement during the baseline survey. The outcome was new-onset HT during the secondary survey, conducted four years after the baseline survey. RESULTS: Overall, 4,021 participants with high normal BP during the baseline survey, with an average age of 58.7 years, were included; 1,030 (26%) were diagnosed with new-onset HT during the secondary survey, 3.5± 0.7 years after the baseline survey. The multivariable odds ratio (95% confidence interval) for HT in the highest versus lowest quartile of central BP was 1.7 (1.2-2.4, p=0.0030), and that of CIMT was 1.8 (1.4-2.4, p＜0.001). Subgroup analysis according to age (＜60 and ≥ 60 years) and sex revealed that the central BP was influential in groups with younger age and female individuals; CIMT was influential in all groups. CONCLUSIONS: Higher central BP and thicker CIMT at the baseline were correlated with new-onset HT in individuals with high normal BP, independent of brachial systolic BP and other cardiovascular risk factors.
産後女性のうつ・自殺関連問題の縦断的リスク評価の記述的分析東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

東北公衆衛生学会誌　(72)　25-25　2023年7月
出版者・発行元：東北公衆衛生学会
ISSN：0915-549X
Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability

Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Ryoko Kimura, Yumiko Hamaie, Mizuki Hino, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Susumu Fujii, Masaharu Nakayama, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

Frontiers in Psychiatry　14　2023年6月6日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fpsyt.2023.1104222 　

eISSN：1664-0640

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Introduction Perinatal women tend to have difficulties with sleep along with autonomic characteristics. This study aimed to identify a machine learning algorithm capable of achieving high accuracy in predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability (HRV). Methods Nine HRV indicators (features) and sleep–wake conditions of 154 pregnant women were measured for 1 week, from the 23rd to the 32nd weeks of pregnancy. Ten machine learning and three deep learning methods were applied to predict three types of sleep–wake conditions (wake, shallow sleep, and deep sleep). In addition, the prediction of four conditions, in which the wake conditions before and after sleep were differentiated—shallow sleep, deep sleep, and the two types of wake conditions—was also tested. Results and Discussion In the test for predicting three types of sleep–wake conditions, most of the algorithms, except for Naïve Bayes, showed higher areas under the curve (AUCs; 0.82–0.88) and accuracy (0.78–0.81). The test using four types of sleep–wake conditions with differentiation between the wake conditions before and after sleep also resulted in successful prediction by the gated recurrent unit with the highest AUC (0.86) and accuracy (0.79). Among the nine features, seven made major contributions to predicting sleep–wake conditions. Among the seven features, “the number of interval differences of successive RR intervals greater than 50 ms (NN50)” and “the proportion dividing NN50 by the total number of RR intervals (pNN50)” were useful to predict sleep–wake conditions unique to pregnancy. These findings suggest alterations in the vagal tone system specific to pregnancy.
Factors associated with new onset of father-to-infant bonding failure from 1 to 6 months postpartum: an adjunct study of the Japan environment and children's study. 国際誌

Taeko Suzuki, Toshie Nishigori, Taku Obara, Miyuki Mori, Kasumi Sakurai, Mami Ishikuro, Hirotaka Hamada, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Hirohito Metoki, Shinichi Kuriyama, Aya Goto, Nobuo Yaegashi, Hidekazu Nishigori

Social psychiatry and psychiatric epidemiology　58　(11)　1603-1624　2023年6月4日

DOI： 10.1007/s00127-023-02505-0 　

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PURPOSE: This study aimed to determine the factors associated with new onset father-to-infant (paternal) bonding failure from 1 to 6 months postpartum. METHODS: This was a prospective birth-cohort study. Paternal bonding failure was evaluated using the Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) at 1 and 6 months postpartum. For cut-off scores, overall bonding failure, MIBS-J total scores ≥ 5; subscale for lack of affection, MIBS-J_LA scores ≥ 3; and subscale for anger/rejection, MIBS-J_AR scores ≥ 3 were used in this study. Multivariate regression analysis was performed to analyze relative variables. RESULTS: We analyzed 872 fathers. The frequency of new-onset overall bonding failure, lack of affection, and anger/rejection was 5.6%, 4.9%, and 6.3%, respectively. For new-onset overall bonding failure, significant associated factors were paternal childcare leave (adjusted odds ratio [AOR] 3.192; 95% confidence interval [CI] 1.203-8.469), paternal new-onset depression symptoms (AOR 3.181; 95% Cl 1.311-7.716), and maternal new-onset overall bonding failure (AOR 4.595; 95% Cl 1.119-18.866). For new-onset lack of affection, significant associated factors were preterm birth (AOR 4.189; 95% Cl 1.473-11.913) and paternal new-onset depression symptoms (AOR 3.290; 95% Cl 1.294-8.362). For new-onset anger and rejection, significant associated factors were paternal childcare leave (AOR 3.142; 95% Cl 1.138-8.676), paternal new-onset depression symptoms (AOR 2.829; 95% Cl 1.133-7.068), and maternal new-onset anger/rejection (AOR 7.064; 95% Cl 2.300-21.700). CONCLUSIONS: The factors associated with new-onset paternal bonding failure from 1 to 6 months postpartum were paternal childcare leave, preterm birth, paternal postpartum depression symptoms, and maternal bonding failure.
Maternal social isolation in the perinatal period and early childhood development: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Social psychiatry and psychiatric epidemiology　58　(11)　1593-1601　2023年6月3日

DOI： 10.1007/s00127-023-02498-w 　

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PURPOSE: Studies examining the associations between maternal social relationships and early childhood development have mainly focused on social relationships after childbirth. We aimed to prospectively examine the associations between the transition of maternal social isolation from the prenatal to postnatal period and early childhood development. METHODS: We analyzed data for 6692 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Social isolation in the prenatal and postnatal periods was assessed by the Lubben Social Network Scale-abbreviated version and categorized into four groups: none, prenatal only, postnatal only, and both. The Ages and Stages Questionnaire, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between maternal social isolation and developmental delays. RESULTS: The prevalence of social isolation in both the prenatal and postnatal periods was 13.1%. Social isolation in both the prenatal and postnatal periods was associated with developmental delays in children at 2 and 3.5 years of age: the multivariate-adjusted odds ratios (95% confidence intervals) were 1.68 (1.39-2.04) and 1.43 (1.17-1.76), respectively. Social isolation in the prenatal period only and social isolation in the postnatal period only were not associated with developmental delays in children at 2 and 3.5 years of age. CONCLUSION: Maternal social isolation in both the prenatal and postnatal periods was associated with an increased risk of developmental delays in early childhood.
妊婦における精神神経用剤服薬および心理的苦痛の有無と2歳時点の児の行動特性との関連

高橋一平, 小原拓, 菊地紗耶, 小林奈津子, 小原竜, 野田あおい, 上野史彦, 大沼ともみ, 村上慶子, 石黒真美, 富田博秋, 栗山進一

精神神経学雑誌　(2023特別号)　S584-S584　2023年6月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
Associations between sugar-sweetened beverages before and during pregnancy and offspring overweight/obesity in Japanese women: the TMM BirThree Cohort Study. 国際誌

Misato Aizawa, Keiko Murakami, Yudai Yonezawa, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Public health nutrition　26　(6)　1222-1229　2023年6月

DOI： 10.1017/S1368980023000307 　

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OBJECTIVE: The association between high sugar-sweetened beverages (SSB) intake during pregnancy and offspring overweight/obesity has been reported only from Western countries. The objective of this study was to examine the association between SSB intake before and during pregnancy and offspring overweight/obesity among Japanese women. DESIGN: Japanese prospective birth cohort study. SETTING: We analysed mother-offspring pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. SSB intake during pregnancy was evaluated using the FFQ and classified into three groups: none (0 g/d), medium (<195 g/d) and high (>195 g/d). Overweight or obesity at 1 year of age in offspring was defined as having a BMI Z-score greater than 2 sd, calculated based on the BMI reference data for Japanese children. Multiple logistic regression analyses were performed to examine the associations between SSB intake before and during pregnancy and offspring overweight/obesity, after adjusting for covariates. PARTICIPANTS: Japanese mother-offspring pairs (n 7114). RESULTS: The overweight/obesity rate of the offspring was 8·8 %. Pregnant women with a high intake of SSB in early to mid-pregnancy had a higher risk of overweight/obesity in their offspring compared with those who did not; the OR was 1·52 (95 % CI (1·09, 2·12)). CONCLUSIONS: High SSB intake in early to mid-pregnancy was associated with an increased risk of offspring overweight/obesity at 1 year of age.
Association between being Overweight in Young Childhood and during School Age and Puberty. 国際誌

Genki Shinoda, Yudai Nagaoka, Fumihiko Ueno, Naoyuki Kurokawa, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

Children (Basel, Switzerland)　10　(5)　2023年5月22日

DOI： 10.3390/children10050909 　

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To examine whether body type at birth, body weight, and obesity in early childhood are associated with overweight/obesity during school age and puberty. Data from maternal and child health handbooks, baby health checkup information, and school physical examination information of participants at birth and three-generation cohort studies were linked. Association between body type and body weight at different time intervals (at birth and at 1.5, 3.5, 6, 11, and 14 years of age) were comprehensively analyzed using a multivariate regression model adjusted for gender, maternal age at childbirth, maternal parity, and maternal body mass index, and drinking and smoking statuses at pregnancy confirmation. Children who are overweight in young childhood had a greater risk of being overweight. Particularly, overweight at one year of age during checkup was associated with overweight at 3.5 years (adjusted odds ratio (aOR), 13.42; 95% confidence interval (CI), 4.46-45.42), 6 years (aOR, 6.94; 95% CI, 1.64-33.46), and 11 years (aOR, 5.22; 95% CI, 1.25-24.79) of age. Therefore, being overweight in young childhood could increase the risk of being overweight and obese during school age and puberty. Early intervention in young childhood may be warranted to prevent obesity during school age and puberty.
Association between low levels of anti-inflammatory cytokines during pregnancy and postpartum depression. 国際誌

Chiaki T Ono, Zhiqian Yu, Taku Obara, Mami Ishikuro, Keiko Murakami, Masahiro Kikuya, Saya Kikuchi, Natsuko Kobayashi, Hisaaki Kudo, Soichi Ogishima, Naoko Minegishi, Junichi Sugawara, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Hiroaki Tomita

Psychiatry and clinical neurosciences　77　(8)　434-441　2023年5月13日

DOI： 10.1111/pcn.13566 　

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AIM: Previous studies based on a relatively limited number of subjects have indicated potential associations between plasma cytokine concentrations in perinatal women and postpartum depression (PPD). This report aimed to examine alterations in cytokine levels during pregnancy and after delivery by measuring nine cytokines in prenatal and postnatal plasma samples in a large cohort. METHODS: A nested, case-control study was conducted using plasma samples from 247 women with PPD (Edinburgh Postnatal Depression Scale: EPDS ≥9) and 243 age-matched control (EPDS ≤2) women from among perinatal women who participated in the Tohoku Medical Megabank three-generation cohort. Concentrations of nine plasma cytokines (IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, and TNF-α) in plasma collected at the time of enrollment during pregnancy and one month after delivery were determined using an immunoassay kit. RESULTS: Cross-sectional comparisons of cytokine levels during pregnancy and after delivery indicated that the PPD group maintained significantly lower plasma IL-4 levels during pregnancy and after delivery than the control group, and that plasma IL-4 levels decreased significantly during pregnancy regardless of PPD status. Plasma IL-10 levels were significantly higher during pregnancy than after delivery only among healthy controls, and plasma IL-10 levels were significantly higher in the control group than in the PPD group. Moreover, IFN-γ, IL-6, IL-12p40, and TNF-α levels were significantly lower during pregnancy compared with after delivery regardless of PPD status. CONCLUSIONS AND RELEVANCE: These results suggest a potential protective effect of the anti-inflammatory cytokines IL-4 and IL-10 during pregnancy against the development of PPD. This article is protected by copyright. All rights reserved.
The prevalence of end-of-life chemotherapy and targeted therapy in Japan, assessed using a health claims database. 国際誌

Masami Tsuchiya, Taku Obara, Masafumi Kikuchi, Nariyasu Mano

Cancer chemotherapy and pharmacology　2023年5月8日

DOI： 10.1007/s00280-023-04535-6 　

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PURPOSE: This study aimed to investigate the current status of end-of-life chemotherapy and targeted therapy and explore the aggressiveness of end-of-life care in Japan using the DeSC database, a large administrative claims database. METHODS: We identified fatal cases of at least one cancer-related diagnosis between April 2015 and November 2020. Patients prescribed at least one anticancer drug were analyzed, and chemotherapy regimens were categorized based on the combination of concomitant anticancer drugs prescribed. RESULTS: Among 1,095,713 individuals enrolled in the National Health Insurance database, 7,300 deaths with cancer-related diagnosis were identified. Of these, 4,010 cases were identified in which at least one anticancer drug was prescribed, and 11.6% of 7,300 death had been prescribed anticancer drugs in their last 30 days of life. The most commonly used regimen was S-1 (tegafur, gimeracil, and oteracil potassium combination) monotherapy, followed by nivolumab monotherapy and nab-paclitaxel plus gemcitabine. Immune checkpoint inhibitor monotherapy was more likely prescribed to patients whose last chemotherapy dose was in the last 30 days of life (p = 0.0066, chi-squared test). CONCLUSIONS: This study provides insights into the current status of end-of-life chemotherapy and targeted therapy in Japan, using a large administrative claims database. The results of this study will inform future research on end-of-life chemotherapy and targeted therapy, and help develop strategies to improve the quality of life of patients with advanced cancer.
高齢者における尿Na/K比の血圧への影響は非高齢者より大きい

平田匠, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 栗山進一, 丹野高三, 寳澤篤

日本老年医学会雑誌　60　(Suppl.)　178-178　2023年5月
出版者・発行元： (一社)日本老年医学会
ISSN：0300-9173
抑うつ症状と家庭高血圧発症リスクの関連東北メディカル・メガバンク計画地域住民コホート調査

時岡紗由理, 中谷直樹, 中谷久美, 小暮真奈, 千葉一平, 畑中里衣子, 菅野郁美, 小原拓, 栗山進一, 寳澤篤

日本循環器病予防学会誌　58　(2)　146-146　2023年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
血圧コントロール不良に対する不十分な高血圧薬物治療による影響リアルワールドデータに基づく解析

佐藤倫広, 室谷智子, 村上任尚, 小原拓, 浅山敬, 大久保孝義, 今井潤, 目時弘仁

日本循環器病予防学会誌　58　(2)　146-146　2023年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
収縮期・拡張期血圧を用いた詳細血圧分類と慢性腎臓病発症リスクの関連

末永司, 佐藤倫広, 村上任尚, 廣瀬卓男, 中山晋吾, 小原拓, 森建文, 今井潤, 大久保孝義, 目時弘仁

日本循環器病予防学会誌　58　(2)　157-157　2023年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
慢性腎臓病発症に対する高血圧と糖尿病の複合効果

遠山真弥, 佐藤倫広, 村上任尚, 橋本英明, 中山晋吾, 小原拓, 中谷直樹, 森建文, 大久保孝義, 今井潤, 寳澤篤, 目時弘仁

日本腎臓学会誌　65　(3)　259-259　2023年5月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

BMC pregnancy and childbirth　23　(1)　268-268　2023年4月19日

DOI： 10.1186/s12884-023-05603-8 　

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BACKGROUND: Low birth weight is associated with an increased risk of developing chronic diseases in adulthood, with a particularly high incidence in Japan among developed countries. Maternal undernutrition is a risk factor for low birth weight, but the association between the timing of food intake and infant birth weight has not been investigated. This study aimed to examine the association between breakfast intake frequency among Japanese pregnant women and infant birth weight. METHODS: Of all pregnant women who participated in the Tohoku Medical Megabank Project Three Generation Cohort Study, 16,820 who answered the required questions were included in the analysis. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: every day and 5-6, 3-4, and 0-2 times/week. Multivariate linear regression models were constructed to examine the association between breakfast intake frequency among pregnant women and infant birth weight. RESULTS: The percentage of pregnant women who consumed breakfast daily was 74% in the pre- to early pregnancy period and 79% in the early to mid-pregnancy period. The average infant birth weight was 3,071 g. Compared to women who had breakfast daily from pre- to early pregnancy, those who had breakfast 0-2 times/week had lower infant birth weight (β = -38.2, 95% confidence interval [CI]: -56.5, -20.0). Similarly, compared to women who had breakfast daily from early to mid-pregnancy, those who had breakfast 0-2 times/week had lower infant birth weight (β = -41.5, 95% CI: -63.3, -19.6). CONCLUSIONS: Less frequent breakfast intake before and mid-pregnancy was associated with lower infant birth weight.
Difficulties in Accessing Medication Records at the Time of a Large-Scale Disaster. 国際誌

Fumihiko Ueno, Keiko Murakami, Masato Nagai, Hiroko Matsubara, Tomomi Oonuma, Fumiko Matsuzaki, Aoi Noda, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Disaster medicine and public health preparedness　17　e370　2023年4月5日

DOI： 10.1017/dmp.2022.301 　

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OBJECTIVE: In a large-scale disaster, medical professionals need to access medication records and provide medicines to people who cannot return home to take their daily medicines. We investigated the proportion of carrying the paper notebook or availability of the smartphone application of the medication record among people who are assumed to have difficulty in taking their medicines during large-scale disasters. METHODS: In Japan, a web-based survey was conducted in 2018 by randomly selecting adults ≥ 20 years of age. RESULTS: There were 2286 medication record owners in 3082 participants. Of the medication record owners, 784 (34.3%) took medicines that could not be missed for even a day. Among them, 724 used paper notebooks alone, 26 used smartphone applications alone, and 34 used both. Among the 724, 208 (28.8%) always carried a paper notebook. Among the 26, 16 (61.5%) could use their applications anytime. Therefore, among the 784, at least 560 (71.4%) could not always access their medication information. CONCLUSIONS: An awareness campaign to carry paper notebooks and install applications for medication records should be held, since only a limited number of people carry their medication records and always have access to their medication information.
Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Acta Paediatrica, International Journal of Paediatrics　112　(4)　776-778　2023年4月

DOI： 10.1111/apa.16662 　

ISSN：0803-5253

eISSN：1651-2227
Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

ACTA PAEDIATRICA　112　(4)　776-778　2023年4月

DOI： 10.1111/apa.16662 　

ISSN：0803-5253

eISSN：1651-2227
Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards. 国際誌

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Acta paediatrica (Oslo, Norway : 1992)　112　(4)　776-778　2023年4月

DOI： 10.1111/apa.16662 　
Maternal social isolation and behavioral problems in preschool children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

European child & adolescent psychiatry　2023年3月30日

DOI： 10.1007/s00787-023-02199-4 　

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It is essential to clarify factors associated with mental health and behavioral problems in early childhood, because children are critical stages of life for mental health. We aimed to prospectively examine the associations between maternal social isolation and behavioral problems in preschool children. We analyzed data from 5842 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores < 12) one year after delivery. The Child Behavior Checklist 1½-5 was used to assess behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations between social isolation and behavioral problems, after adjustment for age, education, income, work status, marital status, extraversion, neuroticism, depressive symptoms, child sex, and number of siblings. Multiple logistic regression analyses were also conducted for internalizing problems and externalizing problems. The prevalence of maternal social isolation was 25.4%. Maternal social isolation was associated with an increased risk of behavioral problems in children: the odds ratio (OR) was 1.37 (95% confidence interval [CI] 1.14-1.64). Maternal social isolation was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.33 (95% CI, 1.12-1.59) and 1.40 (95% CI, 1.18-1.66), respectively. In conclusion, maternal social isolation one year after delivery was associated with behavioral problems in children at 4 years of age.
Cross-classification by systolic and diastolic blood pressure levels and chronic kidney disease, proteinuria, or kidney function decline

Tsukasa Suenaga, Michihiro Satoh, Takahisa Murakami, Takuo Hirose, Taku Obara, Shingo Nakayama, Hideaki Hashimoto, Maya Toyama, Tomoko Muroya, Atsuhiro Kanno, Takefumi Mori, Takayoshi Ohkubo, Yutaka Imai, Hirohito Metoki

Hypertension Research　2023年3月30日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-023-01267-1 　

ISSN：0916-9636

eISSN：1348-4214
母親における出産前後の社会的孤立と児の発達との関連三世代コホート調査

村上慶子, 野田あおい, 石黒真美, 小原拓, 上野史彦, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一

日本衛生学雑誌　78　(Suppl.)　S173-S173　2023年3月
出版者・発行元： (一社)日本衛生学会
ISSN：0021-5082

eISSN：1882-6482
Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Archives of women's mental health　26　(2)　219-226　2023年2月21日

DOI： 10.1007/s00737-023-01298-0 　

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Although there is some evidence regarding an association between maternal bonding disorder and child development, studies have mainly focused on development during the period of infancy. We aimed to examine the associations between maternal postnatal bonding disorder and developmental delays in children beyond 2 years of age. We analyzed data from 8380 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score of ≥5 at 1 month after delivery. The Ages & Stages Questionnaires, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between postnatal bonding disorder and developmental delays after adjustment for age, education, income, parity, feelings toward pregnancy, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. Bonding disorder was associated with developmental delays in children at 2 and 3.5 years of age: the odds ratios (95% confidence intervals) were 1.55 (1.32-1.83) and 1.60 (1.34-1.90), respectively. Bonding disorder was associated with delay in communication only at 3.5 years of age. Bonding disorder was associated with delay in gross motor, fine motor, and problem solving, but not delay in the personal-social domain, at 2 and 3.5 years of age. In conclusion, maternal bonding disorder 1 month after delivery was associated with an increased risk of developmental delays in children beyond 2 years of age.
Association between maternal psychological distress and children's neurodevelopment in offspring aged 4 years in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Ippei Takahashi, Taku Obara, Saya Kikuchi, Mika Kobayashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

Journal of paediatrics and child health　59　(3)　548-554　2023年2月8日

DOI： 10.1111/jpc.16353 　

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AIM: An association between maternal psychological distress and children's development has been reported, but reports from Japan are limited. This study aimed to examine the association of maternal psychological distress with children's neurodevelopment in Japan. METHODS: The study assessed data of 7646 mother-infant pairs in the Japanese population. We used Kessler Psychological Distress Scale, a screening tool for psychological distress, to assess maternal psychological distress in early pregnancy and 2 years postpartum and divided it into four categories: none in both the pre-natal and post-natal periods, only the pre-natal period, only the post-natal period and both the pre-natal and post-natal periods. Children's neurodevelopment was assessed using the Ages & Stages Questionnaires Third Edition (ASQ-3) at 4 years of age. ASQ-3 comprises five domains (communication, gross motor, fine motor, problem solving and personal-social), and the score of less than -2 standard deviation relative to the mean in reference was defined as having developmental delay. We conducted multivariate logistic regression analysis to examine the association between maternal psychological distress and children's neurodevelopment. RESULTS: The prevalence of developmental delay of communication, gross motor, fine motor, problem solving and personal-social were 4.0%, 4.3%, 4.9%, 3.8% and 4.6%, respectively. Maternal psychological distress in only the postpartum period and both pre-natal and postpartum periods were associated with risks of developmental delay in all domains. Maternal psychological distress in only the pre-natal period was associated with developmental delay in communication. CONCLUSIONS: Maternal psychological distress is associated with risks of children's developmental delay.
Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children's Study. 国際誌

Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Kaoh Tanoue, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　46　(4)　834-844　2023年2月3日

DOI： 10.1038/s41440-022-01144-3 　

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Hypertensive disorders of pregnancy (HDP) are associated with poor maternal and neonatal prognoses. Although several studies have indicated an effect of secondhand smoke (SHS) exposure on HDP, such evidence is lacking in Japan. Therefore, we analyzed data from the Japan Environment and Children's Study, a large-scale epidemiological investigation, to elucidate a possible link between SHS exposure and HDP risk. Data were obtained from the all-birth fixed datasets and included information on 104,062 fetuses and their parents. SHS exposure was assessed in terms of the frequency (rarely, 1-3, or 4-7 days/week) and the daily duration of exposure (<1, 1-2, or ≥2 h(s)/day). Modified Poisson regression model analyses were performed with adjustment for known risk factors for HDP. Additionally, the population attributable fractions (PAFs) of SHS exposure and maternal smoking to HDP prevalence were estimated. The relative risks of developing HDP among individuals with SHS exposures of 4-7 days/week and ≥2 h/day were 1.18 and 1.27 (95% confidence interval: 1.02-1.36 and 0.96-1.67), respectively, compared to the reference groups (rare exposure and <1 h/day). The PAFs for the risk of HDP due to SHS exposure and perinatal smoking were 3.8% and 1.8%, respectively. Japanese women with greater exposure to SHS have a higher risk of HDP after adjustment for possible confounding factors; thus, relevant measures are required to reduce SHS exposure to alleviate HDP risk. The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4-7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.
Letter to the Editor: Comment on ‘‘Radiomics with Artificial Intelligence for the Prediction of Early Recurrence in Patients with Clinical Stage IA Lung Cancer’’

Takuma Usuzaki, Kengo Takahashi, Mami Ishikuro, Taku Obara, Takumi Yamaura, Masahiro Kamimoto, Kazuhiro Majima

Annals of Surgical Oncology　30　(2)　912-913　2023年2月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1245/s10434-022-12809-1 　

ISSN：1068-9265

eISSN：1534-4681
乳幼児期のRSウイルス感染の重症化と喘鳴との関連東北メディカル・メガバンク計画三世代コホート調査

上野史彦, 松崎芙美子, 中山慶一, 百瀬敦, 落合秀和, 石黒真美, 村上慶子, 野田あおい, 大沼ともみ, 小原拓, 菅原準一, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　136-136　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
妊婦の朝食摂取頻度と児の出生体重との関連東北メディカル・メガバンク計画三世代コホート調査

相澤美里, 村上慶子, 高橋一平, 大沼ともみ, 野田あおい, 松崎芙実子, 上野史彦, 石黒真美, 小原拓, 濱田裕貴, 岩間憲之, 齋藤昌利, 菅原準一, 八重樫伸生, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　100-100　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
診察室非高血圧者における抑うつ気分と仮面高血圧の関連性の検討

時岡紗由理, 中谷直樹, 千葉一平, 中谷久美, 小暮真奈, 畑中里衣子, 菅野郁美, 小原拓, 栗山進一, 辻一郎

Journal of Epidemiology　33　(Suppl.1)　141-141　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
BMI・飲酒・尿Na/K比と高血圧の関連における両親の高血圧既往の影響

平田匠, 小暮真奈, 畑中里衣子, 千葉一平, 中谷久美, 菅野郁美, 中村智洋, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　155-155　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画地域住民コホート調査(宮城)詳細二次調査の概要

中谷久美, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 中村智洋, 小原拓, 宇留野晃, 布施昇男, 辻一郎, 栗山進一, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　173-173　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
生産児での先天異常の有病割合および診断時期大規模レセプトデータベースを用いた評価

石川智史, 川目裕, 眞野成康, 小原拓

Journal of Epidemiology　33　(Suppl.1)　146-146　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
母親の社会的孤立と児の問題行動の関連東北メディカル・メガバンク計画三世代コホート調査

村上慶子, 石黒真美, 小原拓, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 高橋一平, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 菊谷昌浩, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　92-92　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Weight‐for‐age z ‐scores of Japanese children using the World Health Organization Child Growth Standards

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Acta Paediatrica　112　(4)　776-778　2023年1月17日
出版者・発行元： Wiley
DOI： 10.1111/apa.16662 　

ISSN：0803-5253

eISSN：1651-2227
Maternal postnatal bonding disorder and emotional/behavioral problems in preschool children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Mami Ishikuro, Taku Obara, Aoi Noda, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Journal of affective disorders　325　582-587　2023年1月12日

DOI： 10.1016/j.jad.2023.01.044 　

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BACKGROUND: Although there is some evidence that maternal perinatal mental disorders are associated with emotional/behavioral problems in children, the long-term impacts of postnatal bonding disorder remain unclear. We aimed to examine the associations between maternal postnatal bonding disorder and emotional/behavioral problems in preschool children. METHODS: We analyzed data from 7220 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score ≥5 at 1 month after delivery. The Child Behavior Checklist 1½-5 was used to assess emotional/behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations of postnatal bonding disorder with emotional/behavioral, internalizing, and externalizing problems after adjustment for age, education, income, parity, prenatal psychological distress, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. RESULTS: The prevalence of postnatal bonding disorder was 14.8 %. Postnatal bonding disorder was associated with an increased risk of emotional/behavioral problems in children: the odds ratio (OR) was 2.06 (95 % confidence interval [CI], 1.72-2.46). Postnatal bonding disorder was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.69 (95 % CI, 1.42-2.02) and 1.90 (95 % CI, 1.59-2.26), respectively. LIMITATIONS: Bonding and problems were self-reported. CONCLUSIONS: Bonding disorder at 1 month after delivery was associated with an increased risk of emotional/behavioral problems in children at 4 years of age.
Risk of major congenital malformations associated with first-trimester antihypertensives, including amlodipine and methyldopa: A large claims database study 2010-2019. 国際誌

Tomofumi Ishikawa, Hidekazu Nishigori, Manabu Akazawa, Keiko Miyakoda, Aoi Noda, Mami Ishikuro, Hirohito Metoki, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Pregnancy hypertension　31　73-83　2023年1月9日

DOI： 10.1016/j.preghy.2023.01.001 　

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OBJECTIVES: To evaluate the major congenital malformation (MCM) risk of first-trimester antihypertensive exposure, specifically of amlodipine and methyldopa. STUDY DESIGN: A large administrative claims database was used. MAIN OUTCOME MEASURES: The prevalence of antihypertensive prescriptions during pregnancy was described in 91,390 women giving birth between 2010 and 2019. The MCM risk of first-trimester antihypertensives was evaluated in 1,185 women diagnosed with hypertensive disorders in the first trimester. The MCM risk of first-trimester amlodipine and methyldopa was evaluated in 178 women who were prescribed antihypertensives in the first trimester. RESULTS: Antihypertensives were prescribed to 278 (0.30%) women during their first trimester. The prescription prevalence in the first trimester was highest for methyldopa (115, 0.13%), followed by amlodipine (55, 0.06%). Antihypertensives were prescribed to 2,955 (3.23%) women during pregnancy. Nifedipine (903, 0.99%) and nicardipine (758, 0.83%) were the most frequently prescribed oral and injectable antihypertensives during pregnancy, both with a significant increase in annual prevalence. Of the 1,185 women diagnosed with hypertensive disorders in the first trimester, antihypertensives were prescribed to 178 women. The adjusted odds ratio (aOR) of MCMs in the first-trimester prescription of any antihypertensive medication was 1.124 (95% confidence interval [CI], 0.618-2.045). Amlodipine and methyldopa were prescribed to 44 and 93 of the 178 women, respectively. The aORs of MCMs in the first-trimester prescription of amlodipine and methyldopa were 1.219 (95% CI, 0.400-3.721) and 0.921 (0.331-2.564), respectively. CONCLUSIONS: The MCM risk of first-trimester exposure to antihypertensives, including amlodipine and methyldopa, was not suggested.
Birth Outcomes of Anticancer Drug Prescriptions during Pregnancy: A Case Series from a Japanese Claims Database

Kentaro Tajima, Tomofumi Ishikawa, Masami Tsuchiya, Masafumi Kikuchi, Taku Obara, Nariyasu Mano

Pharmacoepidemiology　2023年1月6日

DOI： 10.3390/pharma2010002 　
No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. 国際誌

Satoko Suzuki, Taku Obara, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Ryutaro Arita, Minoru Ohsawa, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

Frontiers in pharmacology　14　1107494-1107494　2023年

DOI： 10.3389/fphar.2023.1107494 　

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Traditional Japanese (Kampo) medicines containing rhubarb rhizome are prescribed for constipation during pregnancy; however, detailed safety information of their use for pregnant women is lacking. The aim of current study was to clarify the association between prescription Kampo-containing rhubarb rhizome (KRR) in the first trimester of pregnancy and congenital malformations in newborns. Using a large Japanese health insurance claims database, we included pregnant women who enrolled the same health insurance society from 3 months before pregnancy to the delivery date, who gave birth between 2010 and 2019, and those with data related to their infants. Pregnant women who were prescribed magnesium oxide (MgO), commonly used for constipation, during the first trimester of pregnancy and their infants were extracted as controls. Associations between KRR prescribed in the first pregnancy trimester and major congenital malformations (MCM) in the infants were examined using multivariate logistic regression analysis. Of 75,398 infants, 4,607 (6.1%) were diagnosed with MCMs within the first year after birth. Furthermore, 9,852 infants were born to women prescribed MgO, among whom 680 (6.9%) had MCMs; 450 infants were born to women prescribed KRR, among whom 28 (6.2%) had MCMs. Multivariate logistic regression analysis identified no difference in MCM risk between the two types of prescriptions [crude odds ratio (OR) 0.895, 95% confidence interval (CI) 0.606-1.322, adjusted OR 0.889, 95% CI 0.599-1.320]. In conclusion, the risk of MCMs did not differ between those prescribed KRR or MgO in the first trimester of pregnancy.
Dietary calcium intake was related to the onset of pre-eclampsia: The TMM BirThree Cohort Study. 国際誌

Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, Tomomi Onuma, Aoi Noda, Ippei Takahashi, Fumiko Matsuzaki, Fumihiko Ueno, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

Journal of clinical hypertension (Greenwich, Conn.)　25　(1)　61-70　2022年12月28日

DOI： 10.1111/jch.14606 　

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This study aimed to explore the relationship between dietary electrolyte intake and the prevalence of hypertensive disorders of pregnancy (HDP) subtypes. Our analysis included 19 914 pregnant women from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. A food frequency questionnaire was used to estimate dietary calcium, potassium, sodium, and magnesium intakes. HDP was determined based on the medical records during regular antenatal care. Logistic regression analysis assessed the relationship between dietary electrolytes intake quintiles, and HDP subtypes with adjustment for basic characteristics. Dietary electrolyte intakes were applied for the prediction model. Of the cohort, 547 participants delivered with pre-eclampsia (PE), 278 with superimposed PE (SP), and 896 with gestational hypertension (GH). PE was associated with low crude calcium intake (odds ratio of the first quintile [<251 mg/day] to the fifth quintile [>623 mg/day] and 95% confidence interval, 1.31 [1.00-1.70]) and P for trend was .02. SP was not associated with any nutritional intake; however, the combined outcome of PE and SP was related to low crude calcium and potassium and energy-adjusted calcium, potassium, and magnesium intakes (P for trend, .01, .048, .02, .04, and .02, respectively). The same tendency was observed for GH. A prediction model that included crude calcium and potassium intakes performed better than a model without them. In conclusion, low dietary calcium, potassium, and magnesium were associated with higher HDP subtypes prevalence. The prediction model implied that crude calcium and potassium intakes might play a critical role in PE and SP pathogenesis.
Plasma metabolic disturbances during pregnancy and postpartum in women with depression. 国際誌査読有り

Zhiqian Yu, Naomi Matsukawa, Daisuke Saigusa, Ikuko N Motoike, Chiaki Ono, Yasunobu Okamura, Tomomi Onuma, Yuta Takahashi, Mai Sakai, Hisaaki Kudo, Taku Obara, Keiko Murakami, Matusyuki Shirota, Saya Kikuchi, Natsuko Kobayashi, Yoshie Kikuchi, Junichi Sugawara, Naoko Minegishi, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Seizo Koshiba, Hiroaki Tomita

iScience　25　(12)　105666-105666　2022年12月22日

DOI： 10.1016/j.isci.2022.105666 　

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Examining plasma metabolic profiling during pregnancy and postpartum could help clinicians understand the risk factors for postpartum depression (PPD) development. This analysis targeted paired plasma metabolites in mid-late gestational and 1 month postpartum periods in women with (n = 209) or without (n = 222) PPD. Gas chromatogram-mass spectrometry was used to analyze plasma metabolites at these two time points. Among the 170 objected plasma metabolites, principal component analysis distinguished pregnancy and postpartum metabolites but failed to discriminate women with and without PPD. Compared to women without PPD, those with PPD exhibited 37 metabolites with disparate changes during pregnancy and the 1-month postpartum period and an enriched citrate cycle. Machine learning and multivariate statistical analysis identified two or three compounds that could be potential biomarkers for PPD prediction during pregnancy. Our findings suggest metabolic disturbances in women with depression and may help to elucidate metabolic processes associated with PPD development.
Antihypertensive drug use during pregnancy in Japan. 国際誌

Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Keiko Murakami, Shinichi Kuriyama

Hypertension research : official journal of the Japanese Society of Hypertension　46　(2)　548-549　2022年12月2日

DOI： 10.1038/s41440-022-01101-0 　
Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project.

Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Tomomi Onuma, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Akira Uruno, Junichi Sugawara, Kichiya Suzuki, Eiichi N Kodama, Yohei Hamanaka, Naho Tsuchiya, Mana Kogure, Naoki Nakaya, Makiko Taira, Mika Sakurai-Yageta, Toru Tamahara, Junko Kawashima, Maki Goto, Akihito Otsuki, Ritsuko Shimizu, Soichi Ogishima, Hiroaki Hashizume, Fuji Nagami, Tomohiro Nakamura, Atsushi Hozawa, Tadao Kobayashi, Nobuo Fuse, Shinichi Kuriyama, Shigeo Kure, Masayuki Yamamoto

The Tohoku journal of experimental medicine　259　(2)　93-105　2022年12月1日

DOI： 10.1620/tjem.2022.J103 　

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The Tohoku Medical Megabank Project (TMM) has been conducting a birth and three-generation cohort study (the BirThree Cohort Study). We recruited 73,529 pregnant women and their family members for this cohort study, which included 23,143 newborns and 9,459 of their siblings. We designed and are in the process of conducting three-step health assessments for each newborn at approximately ages of 5, 10 and 16. These health assessments are administered at seven community support centers. Trained genome medical research coordinators conduct physical examinations of and collect biological specimens from each participant. The Sendai Children's Health Square has been established as the headquarters for these child health assessments and is utilized to accumulate knowledge that can facilitate the proper practice of child health assessments. We designed all the relevant health assessments facilities to allow parents and their children to participate in the health assessments concomitantly. Our centers serve as places where child participants and their parents can feel at ease as a result of the implementation of safety measures and child hospitality measures. The TMM BirThree Cohort Study is in the process of conducting strategically detailed health assessments and genome analysis, which can facilitate studies concerning the gene-environment interactions relevant to noncommunicable diseases. Through these operations, our study allows for a significant depth of data to be collected in terms of the number of biospecimens under study and the comprehensiveness of both basic and clinical data alongside relevant family information.
Skipping breakfast during pregnancy and hypertensive disorders of pregnancy in Japanese women: the Tohoku medical megabank project birth and three-generation cohort study. 国際誌査読有り

Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

Nutrition journal　21　(1)　71-71　2022年11月17日

DOI： 10.1186/s12937-022-00822-9 　

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BACKGROUND: Hypertensive disorders of pregnancy (HDP) adversely affect the prognosis of mother and child, and the prognosis depends on the subtype of HDP. Skipping breakfast may be associated with increased blood pressure due to disruption of the circadian clock, but the association with the development of HDP has not been studied. The purpose of this study was to examine the association between skipping breakfast and the development of HDP and HDP subtypes in Japanese pregnant women. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 18,839 who answered the required questions were included in the analysis. This study had a cross-sectional design. The breakfast intake frequency from pre-pregnancy to early pregnancy was classified into four groups: daily, 5-6 times per week, 3-4 times per week, and 0-2 times per week. HDP was classified into gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE), and severe preeclampsia (SuPE). Multiple logistic regression analysis and multinomial logistic analysis were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for breakfast intake frequency and development of HDP or HDP subtypes. We performed a stratified analysis based on energy intake. RESULTS: Of the participants, 74.3% consumed breakfast daily, and 11.1% developed HDP. Women who consumed breakfast 0-2 times per week had a higher risk of HDP (OR: 1.33, 95% CI: 1.14-1.56), CH (OR: 1.63, 95% CI: 1.21-2.19), and PE (OR: 1.68, 95% CI: 1.27-2.21) than those who consumed breakfast daily. No association was found between skipping breakfast and the risk of developing GH (OR: 1.26, 95% CI: 0.99-1.61) and SuPE (OR: 0.91, 95% CI: 0.55-1.49). Stratified analysis showed that the risk of developing HDP due to skipping breakfast was highest in the group with the highest daily energy intake. CONCLUSIONS: Skipping breakfast during pre-to early pregnancy is associated with the development of HDP. Further longitudinal studies are required to clarify the causal association between skipping breakfast and HDP.
Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌査読有り

Ippei Takahashi, Keiko Murakami, Mika Kobayashi, Saya Kikuchi, Ayaka Igarashi, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama

BMC psychiatry　22　(1)　693-693　2022年11月11日

DOI： 10.1186/s12888-022-04330-2 　

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BACKGROUND: Childcare facilities are a factor that lowers the established association of mother's postnatal psychiatric symptoms with children's behavioral problems. However, no studies have considered the prenatal psychiatric symptoms yet. This study examined whether the use of childcare facilities moderates the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years. METHODS: The present study was based on the data from 23,130 mother-child pairs participating in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. K6 was used to classify maternal psychological distress in early pregnancy and at two years postpartum into four categories: none in both prenatal and postnatal periods (none), only the prenatal period (prenatal only); only the postnatal period (postnatal only); both prenatal and postnatal periods (both). The children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) aged four years. The clinical range of the externalizing, internalizing, and total problem scales of the CBCL was defined as having behavioral problems. To examine whether availing childcare facilities moderates the association between maternal psychological distress and children's behavioral problems, we conducted a stratified analysis based on the use of childcare facilities or not, at two years of age. The interaction term between maternal psychological distress and use of childcare facilities was included as a covariate in the multivariate logistic regression analysis to confirm the p-value for the interaction. RESULTS: The prevalence of the clinical ranges of externalizing problems, internalizing problems, and clinical range of total problems were 13.7%, 15.4%, and 5.8%, respectively. The association of maternal psychological distress with a high risk of children's behavioral problems was significant; however, the association between prenatal only psychological distress and externalizing problems in the group that did not use childcare facilities was not significant. Interactions between the use of childcare facilities and maternal psychological distress on behavioral problems in children were not significant. CONCLUSIONS: Use of childcare facilities did not moderate the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years.
Actual status of patient information sharing among healthcare delivery facilities: a survey by the third subcommittee, committee on academic research, the Japanese society of hospital pharmacists. 国際誌

Daisuke Kikuchi, Masami Tsuchiya, Shiro Hatakeyama, Yuichi Tasaka, Takeshi Uchikura, Ryohkan Funakoshi, Taku Obara

Journal of pharmaceutical health care and sciences　8　(1)　30-30　2022年11月4日

DOI： 10.1186/s40780-022-00260-z 　

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BACKGROUND: Information sharing among medical professionals is important for providing quality medical care. The purpose of the present study was to elucidate the actual status of information sharing between hospitals and other healthcare delivery facilities by surveying information sharing among the pharmaceutical departments of Japanese hospitals in 2020 conducted by the Japanese Society of Hospital Pharmacists. METHODS: Responses were received from 3612 (43.6%) of the 8278 target medical institutions between May 2020 and August 2020. RESULTS: The proportions of hospitals that shared information with community pharmacies, other hospitals, and long-term nursing homes were 40.6%, 36.4%, and 27.3%, respectively. While tracing reports were the most common tool used by hospitals for information sharing with community pharmacies (54.3%), drug summaries were used for sharing information with other hospitals and long-term nursing homes (77.4% and 78.0%, respectively). The proportion of hospitals sharing information with community pharmacies and other hospitals showed a tendency to increase as the number of hospital beds increased. No relationship could be established between the number of hospital beds and the proportion of hospitals sharing information with long-term nursing homes. CONCLUSION: Information between hospitals and community pharmacies was shared primarily using tracing reports, whereas information between hospitals and other hospitals and long-term nursing homes was primarily shared via drug summaries.
Similarities in cardiometabolic risk factors among random male-female pairs: a large observational study in Japan. 国際誌

Naoki Nakaya, Kumi Nakaya, Naho Tsuchiya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ikumi Kanno, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Shinichi Kuriyama

BMC public health　22　(1)　1978-1978　2022年10月28日

DOI： 10.1186/s12889-022-14348-6 　

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BACKGROUND: Previous observational studies have shown similarities in cardiometabolic risk factors between spouses. It is still possible that this result reflects the age similarity of spouses rather than environmental factors of spouses (e.g. cohabitation effect). To clarify the importance of mate cardiometabolic risk factors for similarity of environmental factors, it is necessary to examine whether they are observed in random male-female pairs while maintaining the age of the spousal pairs. This study aimed to determine whether the similarities found between spousal pairs for cardiometabolic risks were also observed between random male-female pairs. METHODS: This cross-sectional study included 5,391 spouse pairs from Japan; data were obtained from a large biobank study. For pairings, women of the same age were randomly shuffled to create new male-female pairs of the same age as that of the original spouse pairs. Similarities in cardiometabolic risk factors between the random male-female pairs were analysed using Pearson's correlation or age-adjusted logistic regression analyses. RESULTS: The mean ages of the men and women were 63.2 and 60.4 years, respectively. Almost all cardiometabolic risk factors similarities were not noted in cardiometabolic risk factors, including the continuous risk factors (anthropometric traits, blood pressure, glycated haemoglobin level, and lipid traits); lifestyle habits (smoking, drinking, and physical activity); or diseases (hypertension, type 2 diabetes mellitus, and metabolic syndrome) between the random male-female pairs. The age-adjusted correlation coefficients ranged from - 0.007 for body mass index to 0.071 for total cholesterol. The age-adjusted odds ratio (95% confidence interval) for current drinkers was 0.94 (0.81 - 1.09); hypertension, 1.07 (0.93 - 1.23); and type 2 diabetes mellitus, 1.08 (0.77 - 1.50). CONCLUSION: In this study, few similarities in cardiometabolic risk factors were noted among the random male-female pairs. As spouse pairs may share environmental factors, intervention strategies targeting lifestyle habits and preventing lifestyle-related diseases may be effective.
Social isolation and insomnia among pregnant women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Sleep health　8　(6)　714-720　2022年10月10日

DOI： 10.1016/j.sleh.2022.08.007 　

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OBJECTIVES: To estimate the prevalence of insomnia and examine the association between social isolation and insomnia among pregnant women. METHODS: This cross-sectional study was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Pregnant women were recruited at obstetric clinics and hospitals in Miyagi Prefecture, Japan. We analyzed 17,586 women who completed the questionnaires and were allowed to transcribe medical records. Insomnia was defined as the Athens Insomnia Scale score of ≥6. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores <12), and its subscales were used to assess marginal family ties and marginal friendship ties. Multiple logistic regression analyses were conducted to examine the association between social isolation and insomnia during pregnancy, adjusting for age, parity, prepregnancy body mass index, feelings toward pregnancy, education, income, work status, morning sickness, and psychological distress. Multiple logistic regression analyses were also conducted for marginal family ties and marginal friendship ties. RESULTS: The prevalence of insomnia in the second trimester was 37.3%. Women who were socially isolated were more likely to have insomnia than women who were socially integrated: the multivariate-adjusted odds ratio (OR) was 1.26 (95% confidence interval [CI], 1.16-1.36). Marginal family ties and marginal friendship ties were also associated with increased risks of insomnia: the multivariate-adjusted ORs were 1.40 (95% CI, 1.25-1.56) and 1.15 (95% CI, 1.07-1.24), respectively. CONCLUSIONS: Social isolation from family and friends was associated with increased risks of insomnia among pregnant women.
妊娠中の降圧薬使用による血圧管理状況と児のSGAとの関連

石黒真美, 小原拓, 野田あおい, 上野史彦, 松崎芙実子, 大沼ともみ, 村上慶子, 菊谷昌浩, 目時弘仁, 菅原準一, 栗山進一

DOHaD研究　10　(2)　68-68　2022年10月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
妊婦への大黄含有漢方薬の処方と出生児の先天奇形との関連に関する研究大規模レセプトデータベースを用いて

鈴木聡子, 小原拓, 石川智史, 有田龍太郎, 大澤稔, 野田あおい, 松崎芙実子, 菊地章子, 高山真, 眞野成康, 石井正

DOHaD研究　10　(2)　66-66　2022年10月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
東北メディカル・メガバンク計画三世代コホート調査概要と進捗

小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 中谷直樹, 寳澤篤, 菅原準一, 栗山進一

DOHaD研究　10　(2)　80-80　2022年10月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
妊婦に対する抗菌薬処方の実態レセプトデータベースに基づく検討

森下啓, 石川智史, 小原竜, 野田あおい, 松崎芙実子, 石黒真美, 眞野成康, 栗山進一, 小原拓

DOHaD研究　10　(2)　79-79　2022年10月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Journal of affective disorders　320　461-467　2022年9月30日

DOI： 10.1016/j.jad.2022.09.139 　

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BACKGROUND: Natural disasters can have serious mental health consequences. We aimed to examine the long-term effects of the 2011 Great East Japan Earthquake (GEJE) on postpartum depressive symptoms (PDS). METHODS: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women in Miyagi Prefecture from 2013 to 2016. Data from 11,403 participants were used in this study. Women were asked about their traumatic experiences of the GEJE with questions addressing threat, witness, and loss. PDS were defined as Edinburgh Postnatal Depression Scale score ≥9 at 1 month after delivery. Multiple logistic regression analyses were conducted to examine the associations of different traumatic experiences of the GEJE and number of traumatic experiences with PDS, after adjustment for age, parity, feelings toward pregnancy, education, income, social isolation, house damage caused by the GEJE, and survey year. RESULTS: About two-fifths of women had at least one traumatic experience of the GEJE. The prevalence of PDS at 1 month after delivery was 13.3 %. Life-threatening experience and witnessing another person's actual or threatened death were associated with PDS: the odds ratios (ORs) were 1.40 (95 % confidence interval [CI], 1.24-1.59) and 1.28 (95 % CI, 1.08-1.53), respectively. Loss of close person was not associated with PDS: the OR was 1.13 (95 % CI, 0.99-1.30). Larger number of traumatic experiences of the GEJE was associated with increased risk of PDS (p for trend <0.001). LIMITATIONS: PDS was self-reported. CONCLUSIONS: Traumatic experiences of the GEJE prior to pregnancy were associated with increased risks of PDS.
Liver steatosis and fibrosis markers' association with cardiovascular and renal damage in Japanese adults: the TMM BirThree cohort study. 国際誌

Toshiya Machida, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Jun Inoue, Shinichi Kuriyama, Nariyasu Mano

Annals of hepatology　28　(1)　100761-100761　2022年9月27日

DOI： 10.1016/j.aohep.2022.100761 　

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INTRODUCTION AND OBJECTIVES: Patients with non-alcoholic fatty liver disease (NAFLD) are at risk for cardiovascular and chronic kidney diseases. Liver steatosis and fibrosis were assessed using the fatty liver index and fibrosis-4 index, respectively. This study aimed to examine the association between these two parameters in patients with atherosclerosis and chronic kidney disease. METHODS: The two parameters were calculated for 11,867 adults who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Intima-media thickness and estimated glomerular filtration rate were also measured. Logistic regression models were used to estimate the odds ratios (OR). RESULTS: Overall, 4,257 (35.9%) and 4,733 (39.9%) participants had a higher probability of liver steatosis and fibrosis, respectively. The adjusted OR of higher fatty liver index compared to lower fatty liver index for atherosclerosis and chronic kidney disease were 0.98 (95% confidence interval [CI], 0.77-1.24) and 1.79 (95% CI, 1.19-2.69), and those of higher FIB-4 compared to lower FIB-4 were 1.03 (95% CI, 0.82-1.30) and 0.79 (95% CI, 0.52-1.19) for atherosclerosis and chronic kidney disease, respectively. CONCLUSIONS: A higher FLI was associated with CKD independent of other risk factors. Further research is required to identify the causal relationship between liver fat accumulation and CKD.
Social isolation and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Archives of Women's Mental Health　2022年9月17日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s00737-022-01266-0 　

ISSN：1434-1816

eISSN：1435-1102
Dietary patterns before and during pregnancy and small for gestational age in Japan: a prospective birth cohort study

Takahiro Yamashita, Taku Obara, Yudai Yonezawa, Ippei Takahashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Noriyuki Iwama, Hirotaka Hamada, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Masatoshi Saito, Nobuo Yaegashi, Shinichi Kuriyama

Nutrition Journal　21　(1)　2022年9月16日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/s12937-022-00808-7 　

eISSN：1475-2891

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Abstract Background Although small for gestational age (SGA) is a serious problem worldwide, the association of dietary patterns before and during pregnancy with SGA risk is unclear. We evaluated this association among Japanese pregnant women using three methods: reduced rank regression (RRR) and partial least squares (PLS), methods for extracting dietary patterns that can explain the variation of response variables, and principal component analysis (PCA), a method for extracting dietary patterns of the population. Methods Between July 2013 and March 2017, 22,493 pregnant women were recruited to the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a population-based prospective birth cohort study in Japan. Information on dietary intake was obtained using food frequency questionnaires, and dietary patterns were extracted using RRR, PLS, and PCA. Information on birth weight was obtained from obstetric records, and the birth weight SD score and SGA were defined by the method of the Japan Pediatric Society. The associations of dietary patterns with birth weight SD score and SGA risk were investigated using multiple linear regression and multiple logistic regression, respectively. Results A total of 17,728 mother-child pairs were included. The birth weight SD score was 0.15 ± 0.96, and the prevalence of SGA was 6.3%. The dietary patterns extracted by RRR and PLS were similar and characterized by a high intake of cereals and fruits and a low intake of alcoholic and non-alcoholic beverages in both pre- to early pregnancy and from early to mid-pregnancy. Higher adoption of the RRR and PLS patterns in both periods was associated with an increased birth weight SD score and lower risk of SGA. In contrast, the PCA1 pattern was not associated with birth weight SD score or SGA risk in either period. Although the PCA2 pattern was associated with increased birth weight SD score from early to mid-pregnancy, no other associations with birth weight SD score or SGA risk were observed. Conclusions The dietary pattern with a high intake of cereals and fruits and a low intake of alcoholic and non-alcoholic beverages before and during pregnancy was associated with a decreased SGA risk in Japan.
東日本大震災による自宅の被害状況と高血圧治療中断との関連

畑中里衣子, 中谷直樹, 小暮真奈, 中谷久美, 千葉一平, 菅野郁美, 中村智洋, 後岡広太郎, 小原拓, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　196-196　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
過敏性腸症候群の有病に関連する要因の検討 TMM計画地域住民コホート調査

中谷久美, 中谷直樹, 永家聖, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 金澤素, 荻島創一, 栗山進一, 辻一郎, 寳澤篤, 福土審

日本公衆衛生学会総会抄録集　81回　201-201　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
Prescription trends in anti-seizure medications for adult patients with epilepsy in Japan: A retrospective cohort study using the database of health insurance claims between 2015 and 2019

Kazutaka Jin, Taku Obara, Kyoko Hirano, Daichi Hirai, Masatoshi Kiuchi, Takeshi Tanaka, Nobukazu Nakasato

Epilepsy and Behavior　134　2022年9月

DOI： 10.1016/j.yebeh.2022.108841 　

ISSN：1525-5050

eISSN：1525-5069
Pharmacists' knowledge of automated blood pressure devices. 国際誌

Aoi Noda, Taku Obara, Yutaka Imai

Journal of human hypertension　2022年8月26日

DOI： 10.1038/s41371-022-00746-1 　
Effectiveness of Influenza Vaccination among Children in Satellite Cities of a Metropolitan Area in Tokyo, Japan during the 2014/2015-2018/2019 Season.

Ayako Matsuda, Kei Asayama, Taku Obara, Naoto Yagi, Takayoshi Ohkubo

The Tohoku journal of experimental medicine　258　(1)　69-78　2022年8月18日

DOI： 10.1620/tjem.2022.J057 　

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Influenza vaccination is recommended for children. In particular, those aged 6 months to 12 years were recommended two vaccinations in Japan, whereas the recommended year range for the twice vaccination is 6 months to 8 years by the World Health Organization (WHO). This study assessed the effectiveness of influenza vaccination and whether the twice vaccinations enhanced preventive effects against influenza infection among children living in two satellite cities of a metropolitan area in Tokyo, Japan. During the influenza season of 2014-2018, parents of all preschool, elementary school, and junior high school children participated in an annual survey. Adjusted odds ratios (AOR) with 95% confidence intervals (CIs) were calculated via multivariate logistic regression analysis to evaluate influenza vaccination effectiveness and trends in the number of vaccinations. Among the 108,362 children who received the research questionnaire, 76,753 (70.8%) responded. After excluding responses without basic information, 64,586 children were included in the analysis. Vaccination was more effective in preschool and lower grade elementary school children given the increase in the number of vaccinations (test for trend: P < 0.001). The AOR of influenza for pre, grade 1 elementary, and grade 2 schoolchildren who received two vaccinations was 0.63 (95% CI, 0.59-0.69), 0.75 (0.67-0.83), and 0.81 (0.71-0.92), respectively, when compared to those without vaccination. However, no trend in vaccinations and their effectiveness was observed in the third and higher-grade school children. Our findings support the recommendation by the WHO, and could help guide influenza vaccination policies for children in Japan.
Actual impact of angiotensin II receptor blocker or calcium channel blocker monotherapy on renal function in real-world patients. 国際誌

Michihiro Satoh, Takuo Hirose, Hironori Satoh, Shingo Nakayama, Taku Obara, Takahisa Murakami, Tomoko Muroya, Kei Asayama, Masahiro Kikuya, Takefumi Mori, Yutaka Imai, Takayoshi Ohkubo, Hirohito Metoki

Journal of hypertension　40　(8)　1564-1576　2022年8月1日

DOI： 10.1097/HJH.0000000000003186 　

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OBJECTIVE: This observational retrospective cohort study investigates the effect of antihypertensive therapy with angiotensin II receptor blockers (ARBs) or dihydropyridine calcium channel blockers (dCCBs) monotherapy on renal function using longitudinal real-world health data of a drug-naive, hypertensive population without kidney disease. METHODS: Using propensity score matching, we selected untreated hypertensive participants ( n = 10 151) and dCCB ( n = 5078) or ARB ( n = 5073) new-users based on annual health check-ups and claims between 2008 and 2020. Participants were divided by the first prescribed drug. RESULTS: The mean age was 51 years, 79% were men and the mean estimated glomerular filtration rate (eGFR) was 78 ml/min per 1.73 m 2 . Blood pressure rapidly decreased by approximately 10% in both treatment groups. At the 1-year visit, eGFR levels decreased in the ARB group by nearly 2% but increased in the dCCB group by less than 1%. However, no significant difference was apparent in the annual eGFR change after the 1-year visit. The risk for composite kidney outcome (new-onset proteinuria or eGFR decline ≥30%) was lowest in the ARB group owing to their robust effect on preventing proteinuria: hazard ratio (95% confidence interval) for proteinuria was 0.91 (0.78-1.05) for the dCCB group and 0.54 (0.44-0.65) for the ARB group, compared with that for the untreated group after ending follow-up at the last visit before changing antihypertensive treatment. CONCLUSION: From the present findings based on the real-world data, ARBs can be recommended for kidney protection even in a primary care setting. Meanwhile, dCCB treatment initially increases eGFR with no adverse effects on proteinuria.
Deep embedded clustering by relevant scales and genome-wide association study in autism

Fumihiko Ueno, Tomomi Onuma, Ippei Takahashi, Hisashi Ohseto, Akira Narita, Taku Obara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumiko Matsuzaki, Hirohito Metoki, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama

2022年7月25日

DOI： 10.1101/2022.07.25.500917 　
Prescription trends in anti-seizure medications for adult patients with epilepsy in Japan: A retrospective cohort study using the database of health insurance claims between 2015 and 2019. 国際誌

Kazutaka Jin, Taku Obara, Kyoko Hirano, Daichi Hirai, Masatoshi Kiuchi, Takeshi Tanaka, Nobukazu Nakasato

Epilepsy & behavior : E&B　134　108841-108841　2022年7月25日

DOI： 10.1016/j.yebeh.2022.108841 　

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OBJECTIVE: To investigate whether newer anti-seizure medications (ASMs) are widely prescribed for a range of adult patients in Japan, including patients with previously and newly diagnosed epilepsy, or with focal and generalized epilepsies. METHODS: A retrospective cohort study was conducted using the Japanese insurance claims database including 8.4 million people to identify adults (≥16 years of age) with epilepsy diagnosis code identified between January 2015 and December 2018. Patients were included in the prevalent population if epilepsy was already diagnosed at baseline, and in the incident population if prior baseline data for at least 12 months included no epilepsy diagnosis code or ASM prescription. Patients were followed up from the month when the initial oral ASM was prescribed for up to 4 years until the end of 2019 as long as at least one ASM was prescribed. Proportions of prescribed oral ASMs were analyzed by population with epilepsy (prevalent vs. incident) and classification (focal vs. generalized). Anti-seizure medications were classified into older vs. newer ASMs according to the date of approval before and after 1990, respectively. RESULTS: A total of 24,691 patients fulfilled the eligibility criteria for the analysis. Of these, 21,046 and 3,645 were included in the prevalent and incident populations, respectively. The proportion of older ASMs significantly decreased, whereas the proportion of newer ASMs significantly increased (p < 0.0001) during the study period. This trend was more apparent in the population with incident epilepsy than in that with prevalent epilepsy, and was also apparent in the subgroup of focal epilepsy, but not in that of generalized epilepsy. Levetiracetam was the most frequently prescribed of the newer ASMs. CONCLUSION: Newer ASMs became more widely prescribed throughout the study period in populations with both prevalent and incident epilepsies, as well as the subpopulation with focal epilepsy. The advantages of newer ASMs such as better safety profiles may have led to the increasing proportions of prescriptions and newer ASMs may increase the treatment options for patients.
Validation of the Mother-to-Infant Bonding Scale for Infant Maltreatment by Mothers at One Month Postpartum: An Adjunct Study of the Japan Environment and Children's Study.

Toshie Nishigori, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Miyuki Mori, Taeko Suzuki, Mami Ishikuro, Nozomi Tatsuta, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi, Hidekazu Nishigori

JMA journal　5　(3)　366-369　2022年7月15日

DOI： 10.31662/jmaj.2022-0041 　
Development and validation of claims-based algorithms to identify pregnancy based on data from a university hospital in Japan. 国際誌

Kentaro Tajima, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Kei Morishita, Ryusuke Inoue, Noriyuki Iwama, Hidekazu Nishigori, Junichi Sugawara, Masatoshi Saito, Taku Obara, Nariyasu Mano

Current medical research and opinion　38　(9)　1-8　2022年7月14日

DOI： 10.1080/03007995.2022.2101817 　

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OBJECTIVE: When using administrative data, validation is essential since these data are not collected for research purposes and misclassification can occur. Thus, this study aimed to develop algorithms identifying pregnancy and to evaluate the validity of administrative claims data in Japan. METHODS: All females who visited the Tohoku University Hospital Department of Obstetrics in 2018 were included. The diagnosis, medical procedure, medication, and medical service addition fee data were utilized to identify pregnancy, with the electronic medical records set as the gold standard. Combination algorithms were developed using predefined pregnancy-related claims data with a positive predictive value (PPV) ≥80%. Sensitivity (SE), specificity (SP), PPV, and negative predictive value (NPV) with their corresponding 95% confidence intervals (CIs) were calculated for these combination algorithms. RESULTS: This study included 1,757 females with a mean age of 32.8 (standard deviation: 5.9) years. In general, the individual claims data were able to identify pregnancy with a PPV ≥80%; however, the number of pregnancies identified using a single claims data was limited. Based on the combination algorithm with all of the categories, including diagnosis, medical procedure, medication, and medical service addition, the calculated SE, SP, PPV, and NPV were 73.4% (95% CI: 71.2%-75.4%), 96.9% (95% CI: 89.3%-99.6%), 99.8%,(95% CI: 99.4%-100.0%), and 12.3% (95% CI: 9.6%-15.4%), respectively. CONCLUSIONS: The combination algorithm to identify pregnancy demonstrated a high PPV and moderate SE. The algorithm validated in this study is expected to accelerate future studies that aim to identify pregnancies and evaluate pregnancy outcome.
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 寳澤篤

東北公衆衛生学会誌　(71)　28-28　2022年7月
出版者・発行元：東北公衆衛生学会
ISSN：0915-549X
Time-series analysis of blood pressure changes after the guideline update in 2019 and the coronavirus disease pandemic in 2020 using Japanese longitudinal data. 国際誌

Michihiro Satoh, Takahisa Murakami, Taku Obara, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　45　(9)　1408-1417　2022年6月20日

DOI： 10.1038/s41440-022-00961-w 　

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We assessed blood pressure (BP) changes during fiscal years (April to March of the following year) 2015-2020 to clarify the effect of the state of emergency due to the coronavirus disease 2019 (COVID-19) pandemic in 2020. We then considered BP in 2019 separately, as the Japanese hypertension guidelines were updated in 2019. The present retrospective cohort study extracted data from 157,510 Japanese individuals aged <75 years (mean age: 50.3 years, men: 67.5%) from the annual health check-up data of the DeSC database. The trends in BP were assessed using a repeated measures linear mixed model. After adjusting for the month of health check-ups to exclude seasonal BP variation, systolic BP linearly increased during fiscal years 2015-2018. From the value estimated by the trend in 2015-2018, systolic BP was lower by ≤1 mmHg in fiscal year 2019 among the treated participants. Meanwhile, systolic/diastolic BP (95% confidence interval) increased by 2.11 (1.97-2.24)/1.05 (0.96-1.14) mmHg for untreated women (n = 43,292), 1.60 (1.51-1.70)/1.17 (1.11-1.24) mmHg for untreated men (n = 88,479), 1.92 (1.60-2.23)/0.46 (0.25-0.67) mmHg for treated women (n = 7855), and 1.00 (0.79-1.21)/0.39 (0.25-0.53) mmHg for treated men (n = 17,884) in fiscal year 2020. These increases remained time-dependent covariates after adjustments for age, body mass index, alcohol consumption, smoking, physical activity, and blood sampling indices. Social change due to the pandemic might have increased BP by approximately 1-2/0.5-1 mmHg. Meanwhile, only a slight decrease in BP was observed immediately after the guideline update in Japan.
Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement. 国際誌

Hirohito Metoki, Noriyuki Iwama, Hirotaka Hamada, Michihiro Satoh, Takahisa Murakami, Mami Ishikuro, Taku Obara

Hypertension research : official journal of the Japanese Society of Hypertension　45　(8)　1298-1309　2022年6月20日

DOI： 10.1038/s41440-022-00965-6 　

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Hypertensive disorders of pregnancy increase the risk of adverse maternal and fetal outcomes. In 2018, the Japanese classification of hypertensive disorders of pregnancy was standardized with those of other countries, and a hypertensive disorder of pregnancy was considered to be present if hypertension existed during pregnancy and up to 12 weeks after delivery. Strategies for the prevention of hypertensive disorders of pregnancy have become much clearer, but further research is needed on appropriate subjects and methods of administration, and these have not been clarified in Japan. Although guidelines for the use of antihypertensive drugs are also being studied and standardized with those of other countries, the use of calcium antagonists before 20 weeks of gestation is still contraindicated in Japan because of the safety concerns that were raised regarding possible fetal anomalies associated with their use at the time of their market launch. Chronic hypertension is now included in the definition of hypertensive disorders of pregnancy, and blood pressure measurement is a fundamental component of the diagnosis of hypertensive disorders of pregnancy. Out-of-office blood pressure measurements, including ambulatory and home blood pressure measurements, are important for pregnant and nonpregnant women. Although conditions such as white-coat hypertension and masked hypertension have been reported, determining their occurrence in pregnancy is complicated by the gestational week. This narrative review focused on recent reports on hypertensive disorders of pregnancy, including those related to blood pressure measurement and classification.
Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan

Daisuke Kikuchi, Taku Obara, Ryosuke Miura, Naoto Suzuki, Hiroyuki Hirakawa, Risa Josaka, Misato Ito, Misaki Tokunaga, Kensuke Usui, Kouji Okada

Hypertension Research　2022年6月17日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-022-00956-7 　

ISSN：0916-9636

eISSN：1348-4214
Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. 国際誌

Aoi Noda, Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Zen Watanabe, Naomi Shiga, Noriyuki Iwama, Hamada Hirotaka, Tatsui Otsuka, Masahito Tachibana, Hiroaki Tomita, Masatoshi Saito, Junichi Sugawara, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

BMJ open　12　(6)　e060944　2022年6月7日

DOI： 10.1136/bmjopen-2022-060944 　

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OBJECTIVES: This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: The study population consisted of mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire. OUTCOME MEASURES: The children's neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. We performed a multivariate logistic regression analysis of the association between infertility treatment (including ovulation induction (OI), artificial insemination with husband's sperm (AIH) and assisted reproductive technology (ART)) and the clinical range of ASQ-3. RESULTS: Of 9655 mother-child pairs, 273 (2.8%) and 487 (5.0%) were conceived through OI/AIH and ART, respectively. The odds of having developmental delays at 2 years of age were higher in children conceived through OI/AIH (OR, 1.36; 95% CI 1.00 to 1.85) and ART (OR, 1.36; 95% CI 1.07 to 1.72) than in those conceived naturally. Additionally, OI/AIH and ART were significantly associated with communication (OR, 1.93; 95% CI 1.25 to 2.98) and gross motor (OR, 1.50; 95% CI 1.08 to 2.09) delays, respectively. There were no statistically significant differences in the odds of having developmental delays at 3.5 years of age in children conceived through OI/AIH (OR, 1.13; 95% CI 0.79 to 1.61) and ART (OR, 1.03; 95% CI 0.78 to 1.37). CONCLUSION: In this study, we found a significant association between infertility treatment and children's neurodevelopment at 2 years of age, whereas no statistically significant differences were found at 3.5 years of age.
健診とレセプトを組合せたデータに基づくAng II受容体拮抗薬と腎機能の関連

佐藤倫広, 廣瀬卓男, 佐藤弘典, 村上任尚, 小原拓, 中山晋吾, 室谷智子, 森建文, 今井潤, 大久保孝義, 目時弘仁

日本医薬品情報学会総会・学術大会講演要旨集　24回　101-101　2022年6月
出版者・発行元： (一社)日本医薬品情報学会
妊娠初期の消化管運動改善薬の大奇形リスク大規模レセプトデータベースを用いた評価

石川智史, 小原拓, 赤沢学, 野田あおい, 大柳元, 都田桂子, 西郡秀和, 川目裕, 八重樫伸生, 栗山進一, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　24回　98-98　2022年6月
出版者・発行元： (一社)日本医薬品情報学会
2010-2019年の妊婦に対する降圧薬処方状況大規模レセプトデータベースを用いた評価

石川智史, 西郡秀和, 赤沢学, 都田桂子, 野田あおい, 石黒真美, 目時弘仁, 八重樫伸生, 栗山進一, 眞野成康, 小原拓

日本医薬品情報学会総会・学術大会講演要旨集　24回　99-99　2022年6月
出版者・発行元： (一社)日本医薬品情報学会
周産期におけるカルシニューリン阻害薬の処方状況と出生児に対する安全性の評価

八島一史, 野田あおい, 石川智史, 松崎芙実子, 都田桂子, 西郡秀和, 眞野成康, 小原拓

日本医薬品情報学会総会・学術大会講演要旨集　24回　100-100　2022年6月
出版者・発行元： (一社)日本医薬品情報学会
妊婦に対する抗精神病薬処方の実態レセプトデータベースに基づく検討

小原竜, 石川智史, 森下啓, 野田あおい, 松崎芙実子, 石黒真美, 栗山進一, 小原拓

日本医薬品情報学会総会・学術大会講演要旨集　24回　108-108　2022年6月
出版者・発行元： (一社)日本医薬品情報学会
【早期に見極めすばやく対応!重篤副作用の予防と治療】副作用報告を実践しよう副作用報告の質向上を目指して

小原拓, 土屋雅美, 眞野成康

薬事　64　(8)　1609-1613　2022年6月
出版者・発行元： (株)じほう
ISSN：0016-5980
イトラコナゾール錠へのリルマザホン混入事例 JADERを用いた解析

土屋雅美, 小原拓, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　24回　99-99　2022年6月
出版者・発行元： (一社)日本医薬品情報学会
レセプトデータベースを用いた妊娠中のがん薬物療法および出産転帰の調査

田島健太郎, 土屋雅美, 石川智史, 小原拓, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　24回　104-104　2022年6月
出版者・発行元： (一社)日本医薬品情報学会
【早期に見極めすばやく対応!重篤副作用の予防と治療】副作用報告を実践しよう副作用報告の質向上を目指して

小原拓, 土屋雅美, 眞野成康

薬事　64　(8)　1609-1613　2022年6月
出版者・発行元： (株)じほう
ISSN：0016-5980
Response to “Scaling up monitoring of risk minimization measures in women of childbearing age with anti-seizure medicines”

Daisuke Kikuchi, Taku Obara, Ryosuke Miura, Naoto Suzuki, Risa Josaka, Misaki Tokunaga, Ryusuke Ouchi, Kensuke Usui, Kouji Okada

Seizure　2022年6月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.seizure.2022.06.014 　

ISSN：1059-1311
Risk scores for predicting small for gestational age infants in Japan: The TMM birthree cohort study. 国際誌

Noriyuki Iwama, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Tetsuro Hoshiai, Masatoshi Saito, Hirohito Metoki, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

Scientific reports　12　(1)　8921-8921　2022年5月26日

DOI： 10.1038/s41598-022-12892-0 　

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This study aimed to construct a prediction model for small-for-gestational-age (SGA) infants in Japan by creating a risk score during pregnancy. A total of 17,073 subjects were included in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study. A multiple logistic regression model was used to construct risk scores during early and mid-gestational periods (11-17 and 18-21 weeks of gestation, respectively). The risk score during early gestation comprised the maternal age, height, body mass index (BMI) during early gestation, parity, assisted reproductive technology (ART) with frozen-thawed embryo transfer (FET), smoking status, blood pressure (BP) during early gestation, and maternal birth weight. The risk score during mid-gestation also consisted of the maternal age, height, BMI during mid-gestation, weight gain, parity, ART with FET, smoking status, BP level during mid-gestation, maternal birth weight, and estimated fetal weight during mid-gestation. The C-statistics of the risk scores during early- and mid-gestation were 0.658 (95% confidence interval [CI]: 0.642-0.675) and 0.725 (95% CI: 0.710-0.740), respectively. In conclusion, the predictive ability of the risk scores during mid-gestation for SGA infants was acceptable and better than that of the risk score during early gestation.
Itraconazole Contaminated with Rilmazafone in Japan: A Retrospective Analysis Using the Japanese Adverse Drug Event Report Database. 国際誌

Masami Tsuchiya, Taku Obara, Nariyasu Mano

Drugs - real world outcomes　9　(3)　315-319　2022年5月23日

DOI： 10.1007/s40801-022-00306-6 　

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BACKGROUND: In early December 2020, the antifungal medication, itraconazole (ITCZ), was mistakenly contaminated with rilmazafone in Japan. Healthcare professionals reported adverse drug reaction reports associated with ITCZ and included central nervous system-depression symptoms such as dizziness, lightheadedness, loss of consciousness, and intense drowsiness. OBJECTIVE: We examined ITCZ-associated suspicious cases using the Japanese Adverse Drug Event Report (JADER) database to determine the impact of adverse drug reaction reporting on post-marketing safety measures. METHODS: Adverse drug reaction reports in which the suspicious or concomitant medication was ITCZ or fluconazole (FLCZ) were extracted from the JADER dataset. The number of adverse drug reaction reports associated with central nervous system-depression adverse drug reactions were counted, and chronological changes were compared with ITCZ and FLCZ. RESULTS: Of the 713,893 adverse drug reaction reports in the JADER database, 5048 cases were associated with ITCZ and 6007 cases with FLCZ. When ITCZ contamination occurred, the number of adverse drug reaction reports associated with ITCZ increased rapidly, while those with FLCZ did not. In addition, the proportion of central nervous system-depression adverse drug reactions increased only in the ITCZ-associated report. CONCLUSIONS: An incident of ITCZ contamination with rilmazafone was detected on the JADER retrospectively. This case highlights the importance of spontaneous adverse drug reaction reporting, even if the causal relationship between the drug and adverse drug reaction is unknown.
Validity of Administrative Data for Identifying Birth-Related Outcomes with the End Date of Pregnancy in a Japanese University Hospital. 国際誌

Kentaro Tajima, Tomofumi Ishikawa, Fumiko Matsuzaki, Aoi Noda, Kei Morishita, Ryusuke Inoue, Noriyuki Iwama, Hidekazu Nishigori, Junichi Sugawara, Masatoshi Saito, Taku Obara, Nariyasu Mano

International journal of environmental research and public health　19　(8)　2022年4月16日

DOI： 10.3390/ijerph19084864 　

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This study aimed to develop and validate claims-based algorithms for identifying live birth, fetal death, and cesarean section by utilizing administrative data from a university hospital in Japan. We included women who visited the Department of Obstetrics at a university hospital in 2018. The diagnosis, medical procedures, and medication data were used to identify potential cases of live birth, fetal death, and cesarean section. By reviewing electronic medical records, we evaluated the positive predictive values (PPVs) and the accuracy of the end date of pregnancy for each claims datum. "Selected algorithm 1" based on PPVs and "selected algorithm 2" based on both the PPVs and the accuracy of the end date of pregnancy were developed. A total of 1757 women were included, and the mean age was 32.8 years. The PPVs of "selected algorithm 1" and "selected algorithm 2" were both 98.1% for live birth, 99.0% and 98.9% for fetal death, and 99.7% and 100.0% for cesarean section, respectively. These findings suggest that the developed algorithms are useful for future studies for evaluating live birth, fetal death, and cesarean section with an accurate end date of pregnancy.
Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Scientific reports　12　(1)　6400-6400　2022年4月16日

DOI： 10.1038/s41598-022-09944-w 　

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Personality has been shown to predict postpartum depressive symptoms (PDS) assessed by the Edinburgh Postnatal Depression Scale (EPDS). However, existing studies have not considered the underlying symptom dimensions in the EPDS. We analyzed data from 15,012 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised. PDS were defined as EPDS score ≥ 9 at 1 month after delivery. The EPDS items were further divided into three dimensions: depressed mood, anxiety, and anhedonia. Multiple analyses were conducted to examine the associations of each personality scale with PDS and three dimensions in the EPDS, adjusting for age, parity, mode of delivery, education, income, and social isolation. The prevalence of PDS assessed by the EPDS at 1 month after delivery was 13.1%. Higher neuroticism scores were associated with PDS (odds ratio [OR], 2.63; 95% confidence interval [CI], 2.48 to 2.79) and all three dimensions (all p < 0.001). Lower extraversion scores were associated with PDS (OR, 0.74; 95% CI, 0.70 to 0.78) and all three dimensions (all p < 0.001). Lower psychoticism scores were associated with PDS (OR, 0.89; 95% CI, 0.85 to 0.94) and anxiety (p < 0.001), but not with depressed mood (p = 0.20) or anhedonia (p = 0.92). In conclusion, higher neuroticism and lower extraversion were associated with PDS and the three underlying dimensions in the EPDS, while lower psychoticism was associated with anxiety, but not with depressed mood or anhedonia.
A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. 査読有り

Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, Yoichi Suzuki, Kichiya Suzuki, Akira Uruno, Mika Sakurai-Yageta, Yohei Hamanaka, Makiko Taira, Soichi Ogishima, Shinichi Kuriyama, Atsushi Hozawa, Hiroaki Tomita, Naoko Minegishi, Junichi Sugawara, Inaho Danjoh, Tomohiro Nakamura, Tomoko Kobayashi, Yumi Yamaguchi-Kabata, Shu Tadaka, Taku Obara, Eiji Hishimuma, Nariyasu Mano, Masaki Matsuura, Yuji Sato, Masateru Nakasone, Yohei Honkura, Jun Suzuki, Yukio Katori, Yoichi Kakuta, Atsushi Masamune, Yoko Aoki, Masaharu Nakayama, Shigeo Kure, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto

JMA journal　5　(2)　177-189　2022年4月15日

DOI： 10.31662/jmaj.2021-0156 　

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Introduction: Pharmacogenomic (PGx) testing results provide valuable information on drug selection and appropriate dosing, maximization of efficacy, and minimization of adverse effects. Although the number of large-scale, next-generation-sequencing-based PGx studies has recently increased, little is known about the risks and benefits of returning PGx results to ostensibly healthy individuals in research settings. Methods: Single-nucleotide variants of three actionable PGx genes, namely, MT-RNR1, CYP2C19, and NUDT15, were returned to 161 participants in a population-based Tohoku Medical Megabank project. Informed consent was obtained from the participants after a seminar on the outline of this study. The results were sent by mail alongside sealed information letter intended for clinicians. As an exception, genetic counseling was performed for the MT-RNR1 m.1555A > G variant carriers by a medical geneticist, and consultation with an otolaryngologist was encouraged. Questionnaire surveys (QSs) were conducted five times to evaluate the participants' understanding of the topic, psychological impact, and attitude toward the study. Results: Whereas the majority of participants were unfamiliar with the term PGx, and none had undergone PGx testing before the study, more than 80% of the participants felt that they could acquire basic PGx knowledge sufficient to understand their genomic results and were satisfied with their potential benefit and use in future prescriptions. On the other hand, some felt that the PGx concepts or terminology was difficult to fully understand and suggested that in-person return of the results was desirable. Conclusions: These results collectively suggest possible benefits of returning preemptive PGx information to ostensibly healthy cohort participants in a research setting.
Trends in the prescription of anti-seizure medicines for pregnant women outpatients with epilepsy during 2016–2020 in Japan

Daisuke Kikuchi, Taku Obara, Ryosuke Miura, Naoto Suzuki, Risa Josaka, Misaki Tokunaga, Ryusuke Ouchi, Kensuke Usui, Kouji Okada

Seizure　2022年4月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.seizure.2022.04.007 　

ISSN：1059-1311
Characteristics of hospitals that report adverse drug reactions: Results of a nationwide survey in Japan

Masami Tsuchiya, Daisuke Kikuchi, Shiro Hatakeyama, Yuichi Tasaka, Takeshi Uchikura, Ryohkan Funakoshi, Taku Obara

Journal of Clinical Pharmacy and Therapeutics　2022年3月31日
出版者・発行元： Wiley
DOI： 10.1111/jcpt.13661 　

ISSN：0269-4727

eISSN：1365-2710
Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study. 国際誌

Chikana Kawaguchi, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Shinichi Kuriyama, Taku Obara

BMC pregnancy and childbirth　22　(1)　242-242　2022年3月24日

DOI： 10.1186/s12884-022-04556-8 　

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BACKGROUND: Maternal mental health problems in each of the prenatal period and postnatal period have been demonstrated as possible risk factors for atopic dermatitis (AD) in children. However, the cumulative impacts of maternal psychological distress in the prenatal and postnatal periods on AD in children remain unclear. This study examined the association between cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and the development of AD in children. METHODS: Data were derived from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. In total, 8377 mother-child pairs in which the child had no AD at the age of 1 year were analyzed. Maternal psychological distress in early pregnancy and 1 year after delivery was defined as a K6 score ≥ 5, and the participants were categorized into four groups: no psychological distress in both the prenatal and postnatal periods; only the prenatal period; only the postnatal period; and both periods. The development of AD was defined as the presence of AD in a 2-year-old child without AD reported at the age of 1 year using the International Study of Asthma and Allergies in Childhood questionnaire. Generalized linear model analyses were conducted to examine the association between maternal psychological distress and the development of AD in children adjusted for age at delivery, educational attainment, smoking status in pregnancy, maternal history of AD, paternal history of AD, parity, maternal body mass index, and child sex. RESULTS: Between the ages of 1 and 2 years, 14.0% of children developed AD. Maternal psychological distress in both prenatal and postnatal periods was associated with an increased risk of AD in children compared to no psychological distress in both periods (relative risk (RR), 95% confidence interval (CI): 1.34, 1.20-1.47). Maternal psychological distress in only the postnatal period was associated with an increased risk of AD in children (RR, 95% CI: 1.23, 1.07-1.39), but not in only the prenatal period (RR, 95% CI: 1.14, 0.98-1.30). CONCLUSIONS: Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods was associated with the development of AD in children.
Trends in drug prescriptions for type 2 diabetes, hypertension, and dyslipidemia among adults with non-alcoholic fatty liver disease. 国際誌

Toshiya Machida, Taku Obara, Makoto Miyazaki, Jun Inoue, Nariyasu Mano

Annals of hepatology　27　(4)　100699-100699　2022年3月9日

DOI： 10.1016/j.aohep.2022.100699 　

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INTRODUCTION AND OBJECTIVES: Clinical guidelines recommend specific drugs for type 2 diabetes (T2D), hypertension, and dyslipidemia in patients with non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH). We aimed to investigate the differences in prescription trends of antidiabetic, antihypertensive, and lipid-lowering drugs among adult patients according to the presence of comorbid NAFLD and/or NASH. METHODS: We conducted a cross-sectional analysis using a large claims database from January 2013 to December 2020. RESULTS: Among 7,716,908 people, 47,157 patients with T2D, 180,050 with hypertension, and 191,348 with dyslipidemia were identified. A total of 8,897, 16,451, and 24,762 patients with NAFLD, as well as 435, 523, and 1033 patients with NASH, had T2D, hypertension, and dyslipidemia, respectively. Among antidiabetic drugs, sodium-glucose cotransporter-2 inhibitors (SGLT2is) and thiazolidine were more frequently prescribed to patients with NAFLD than to those without NAFLD (non-NAFLD) (thiazolidine: 1.4% and 2.8% and SGLT2is: 17.8% and 25.9% for non-NAFLD and NAFLD, respectively [2019-2020]). Among antihypertensive drugs, angiotensin II receptor antagonists exhibited a slightly higher prescription ratio in patients with NAFLD (33.6% vs. 39.0%). Regarding lipid-lowering drugs, fibrates were more frequently prescribed to patients with NAFLD (10.3% vs. 18.4%). CONCLUSIONS: Specific drugs tended to be prescribed to patients with NAFLD. However, the differences in prescription ratios were not considerable. Further investigation is required to confirm the effects of drugs on the prognosis of patients with NAFLD or NASH.
Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan

Nobuo Fuse, Miyuki Sakurai, Ikuko N. Motoike, Kaname Kojima, Takako Takai-Igarashi, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Akiko Miyazawa, Kei Homma, Keisuke Ido, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Akira Uruno, Eiichi N. Kodama, Kichiya Suzuki, Yohei Hamanaka, Hiroaki Tomita, Junichi Sugawara, Yoichi Suzuki, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto

Ophthalmology Science　2　(1)　100113-100113　2022年3月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.xops.2022.100113 　

ISSN：2666-9145
Assessment of Information Sharing on Adverse Drug Reactions by Community Pharmacies with Other Medical Institutions

Daisuke Kikuchi, Taku Obara, Aoi Noda, Gen Oyanagi, Mami Ishikuro, Kouji Okada, Nariyasu Mano

Pharmacy　10　(1)　25-25　2022年2月5日
出版者・発行元： MDPI AG
DOI： 10.3390/pharmacy10010025 　

eISSN：2226-4787

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Widespread coordination and sharing of information regarding adverse drug reactions (ADRs) are important for drug safety assessment. However, the actual status of coordination and sharing of information on ADRs in community pharmacies remains unclear. Therefore, a survey was conducted at community pharmacies to analyze the status. In this cross-sectional study conducted from 31 March 2021 to 9 April 2021, a request letter with the uniform resource locator of the questionnaire form was sent to 302 community pharmacies affiliated with Tsuruha Holdings Inc., and the responses were obtained online. The response rate for the questionnaires was 80.8% (n = 244). In total, 20.9% of the community pharmacies provided information on patients’ ADRs to hospitals or clinics prescribing drugs. None of the community pharmacies provided patient ADR information to other community pharmacies. Of the community pharmacies, 98.8% felt that insufficient information was available to monitor ADRs from hospitals or clinics prescribing drugs. For example, the name of the disease (67.6%), considered to be the most common information, was insufficiently provided. Overall, the existing system for providing information on ADRs between community pharmacies and other medical institutions is insufficient and needs to be developed further.
Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: The Japan Environment and Children's Study. 国際誌

Taeko Suzuki, Toshie Nishigori, Taku Obara, Toshio Masumoto, Miyuki Mori, Tsuyoshi Murata, Hyo Kyozuka, Yuka Ogata, Akiko Sato, Mari Sanpei, Toshifumi Takahashi, Kosei Shinoki, Mitsuaki Hosoya, Keiya Fujimori, Seiji Yasumura, Koichi Hashimoto, Aya Goto, Hidekazu Nishigori

The British journal of nutrition　1-24　2022年2月4日

DOI： 10.1017/S000711452200037X 　

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We evaluated the association between maternal prenatal folic acid supplementation/dietary folate intake and motor and cognitive development in 2-year-old offspring using data from the Japan Environment and Children's Study database. Neurodevelopment of 2-year-old offspring were evaluated using the Kyoto Scale of Psychological Development 2001. In total, data of 3,839 offspring were analysed. For folic acid supplementation, a multiple regression analysis showed that offspring of mothers who started using folic acid supplements before conception had a significantly lower developmental quotient (DQ) in the postural-motor DQ area than offspring of mothers who did not use them at any time throughout their pregnancy (partial regression coefficient [B]: -2.596, 95% confidence interval [CI]: - 4.738 - -0.455). Regarding daily dietary folate intake from preconception to early pregnancy, a multiple regression analysis showed that the group with ≥200 µg had a significantly higher DQ in the language-social area than the group with <200 µg. The DQ was higher in the ≥400 µg group (B: 2.532, 95%CI: 0.201-4.863) than the 200 to <400 µg group (B: 1.437, 95% CI: 0.215-2.660). In conclusion, our study showed that maternal adequate dietary folate intake from preconception to early pregnancy has a beneficial association with verbal cognition development in 2-year-old offspring. On the other hand, mothers who started using folic acid supplements before conception had an inverse association with motor development in 2-year-old offspring. There were no details on the amount of folic acid in the supplements used and frequency of use. Therefore, further studies are required.
研究者の最新動向副作用報告に関する海外実態調査

酒井隆全, 門田佳子, 小原拓

Precision Medicine　5　(2)　166-171　2022年2月
出版者・発行元： (株)北隆館
ISSN：2434-3625
Families' Health after the Great East Japan Earthquake: Findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Mami Ishikuro, Aoii Noda, Keiko Murakami, Tomomi Onuma, Fumiko Matsuzaki, Fumihiko Ueno, Masahiro Kikuya, Hirohito Metoki, Hiroaki Tomita, Taku Obara, Nobuo Yaegashi, Shinichi Kuriyama

The Tohoku journal of experimental medicine　256　(2)　93-101　2022年2月

DOI： 10.1620/tjem.256.93 　

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Infectious diseases, chronic diseases, and mental disorders in both adults and children are reported after disasters occur. The correlation between chronic diseases and mental disorders has also been reported. Moreover, disasters may affect perinatal outcomes. Thus, both adult and child health should be carefully monitored in disaster aftermath. A prospective cohort study of pregnant women and their families, the Tohoku Medical Megabank Project (TMM) Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), has been conducted since 2013. A total of 73,529 family members participated in the TMM BirThree Cohort Study. Among siblings, the proportion of "small for gestational age" was the same in the pre- and post-disaster periods. Among parents and grandparents who answered the baseline questionnaire, 5.6% in the inland area and 19.8% in the coastal area had their houses totally/mostly destroyed by the Great East Japan Earthquake. Although a depression trend due to house damage was not observed in mothers, the proportion of psychological distress was high according to house damage (P for trend = 0.04). Among parents, there was an increase in overweight persons (P for trend = 0.004 in mothers and < 0.0001 in fathers) and in the number of smokers based on the severity of house damage (P for trend = 0.002 in mothers and < 0.0001 in fathers), whereas no such trend was observed in grandparents. Continuous monitoring and support for those who need are essential. Moreover, utilizing existing cohort studies to investigate health status when we face a new disaster is desirable.
乳児期の体重変化と幼児期過体重・肥満との関連東北メディカル・メガバンク計画三世代コホート調査

小林雅幸, 石黒真美, 野田あおい, 大沼ともみ, 松崎芙実子, 上野史彦, 村上慶子, 小原拓, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　100-100　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Association between Recurrence or Exacerbation at Time of Disaster and Allergic Symptoms Several Years Later in Schoolchildren with Asthma or Atopic Dermatitis: The ToMMo Child Health Study

Masako Miyashita, Taku Obara, Mami Ishikuro, Masahiro Kikuya, Shinichi Kuriyama

The Tohoku Journal of Experimental Medicine　257　(1)　23-32　2022年
出版者・発行元： Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j018 　

ISSN：0040-8727

eISSN：1349-3329
Epidemiological survey to establish thresholds for influenza among children in satellite cities of Tokyo, Japan, 2014-2018. 国際誌

Ayako Matsuda, Kei Asayama, Taku Obara, Naoto Yagi, Takayoshi Ohkubo

Western Pacific surveillance and response journal : WPSAR　13　(3)　1-9　2022年

DOI： 10.5365/wpsar.2022.13.3.911 　

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OBJECTIVE: We described the characteristics of children reported as having influenza across five consecutive influenza seasons and investigated the usefulness of setting influenza thresholds in two satellite cities of Tokyo, Japan. METHODS: An annual survey was conducted among parents of children at preschools (kindergartens and nursery schools), elementary schools and junior high schools in Toda and Warabi cities, Saitama prefecture, at the end of the 2014-2018 influenza seasons. Using the World Health Organization method, we established seasonal, high and alert thresholds. RESULTS: There were 64 586 children included in the analysis. Over the five seasons, between 19.1% and 22% of children annually were reported as having tested positive for influenza. Influenza type A was reported as the dominant type, although type B was also reported in more than 40% of cases in the 2015 and 2017 seasons. The median period of the seasonal peak was 3 weeks in mid-January, regardless of school level. Of the five surveyed seasons, the high threshold was reached in 2014 and 2018, with no season exceeding the alert threshold. DISCUSSION: This study provides insights into the circulation of influenza in children in the study areas of Toda and Warabi, Japan, from 2014 to 2018. Although we were able to utilize these annual surveys to calculate influenza thresholds from five consecutive seasons, the prospective usefulness of these thresholds is limited as the survey is conducted at the end of the influenza season.
妊娠初期の消化管運動改善薬処方と児の大奇形との関連大規模レセプトデータベースを用いた評価

石川智史, 小原拓, 赤沢学, 野田あおい, 大柳元, 森下啓, 都田桂子, 西郡秀和, 川目裕, 八重樫伸生, 栗山進一, 眞野成康

Journal of Epidemiology　32　(Suppl.1)　141-141　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
日本人妊婦の食事パターンとSGAとの関連三世代コホート調査

山下貴宏, 小原拓, 米沢祐大, 高橋一平, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 岩間憲之, 菅原準一, 鈴木重徳, 菅沼大行, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　132-132　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
母親の妊娠中と産後の心理的ストレス反応と児の問題行動との関連三世代コホート調査

高橋一平, 村上慶子, 五十嵐彩華, 小林美佳, 菊地紗耶, 大柳元, 野田あおい, 大沼ともみ, 松崎芙実子, 上野史彦, 石黒真美, 小原拓, 菅原準一, 富田博秋, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　143-143　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
首都圏地方都市在住小児におけるインフルエンザワクチン接種とインフルエンザ発症との関連 2014/2015-2018/2019シーズン

松田彩子, 浅山敬, 小原拓, 八木直人, 大久保孝義

Journal of Epidemiology　32　(Suppl.1)　113-113　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 菅野郁美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 呉繁夫, 寳澤篤

Journal of Epidemiology　32　(Suppl.1)　162-162　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Association between smoking and hypertension in pregnancy among Japanese women: a meta-analysis of birth cohort studies in the Japan Birth Cohort Consortium (JBiCC) and JECS

Naho Morisaki, Taku Obara, Aurelie Piedvache, Sumitaka Kobayashi, Chihiro Miyashita, Tomoko Nishimura, Mami Ishikuro, Fumihiro Sata, Reiko Horikawa, Chisato Mori, Hirohito Metoki, Kenji J Tsuchiya, Shinichi Kuriyama, Reiko Kishi

Journal of Epidemiology　2022年
出版者・発行元： Japan Epidemiological Association
DOI： 10.2188/jea.je20220076 　

ISSN：0917-5040

eISSN：1349-9092
妊娠高血圧症候群と産後約3年の血圧値との関連東北メディカル・メガバンク計画三世代コホート調査

石黒真美, 長谷川茉柚, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 菊谷昌浩, 目時弘仁, 小原拓, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　100-100　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
日本人妊婦の食事パターンとSGAとの関連三世代コホート調査

山下貴宏, 小原拓, 米沢祐大, 高橋一平, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 岩間憲之, 菅原準一, 鈴木重徳, 菅沼大行, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　132-132　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
母親の妊娠中と産後の心理的ストレス反応と児の問題行動との関連三世代コホート調査

高橋一平, 村上慶子, 五十嵐彩華, 小林美佳, 菊地紗耶, 大柳元, 野田あおい, 大沼ともみ, 松崎芙実子, 上野史彦, 石黒真美, 小原拓, 菅原準一, 富田博秋, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　143-143　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
妊娠初期の消化管運動改善薬処方と児の大奇形との関連大規模レセプトデータベースを用いた評価

石川智史, 小原拓, 赤沢学, 野田あおい, 大柳元, 森下啓, 都田桂子, 西郡秀和, 川目裕, 八重樫伸生, 栗山進一, 眞野成康

Journal of Epidemiology　32　(Suppl.1)　141-141　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
健康保険組合・国民健康保険の健診データに基づく2018〜2020年度の血圧変化とその要因

佐藤倫広, 村上任尚, 小原拓, 目時弘仁

Journal of Epidemiology　32　(Suppl.1)　128-128　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study

Mana Kogure, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Kotaro Nochioka, Akira Narita, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Taku Obara, Michihiro Satoh, Hirohito Metoki, Ken Miyagawa, Hiroshi Koshimizu, Sho Nagayoshi, Akira Uruno, Masahiro Kikuya, Kichiya Suzuki, Naoki Nakaya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension Research　2022年

DOI： 10.1038/s41440-021-00843-7 　

ISSN：0916-9636

eISSN：1348-4214
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. 国際誌

Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

Human genome variation　8　(1)　44-44　2021年12月10日

DOI： 10.1038/s41439-021-00175-5 　

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To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.
Prenatal folic acid supplementation and autism spectrum disorder in 3-year-old offspring: the Japan environment and children's study. 国際誌

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Mami Ishikuro, Nozomi Tatsuta, Kasumi Sakurai, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　35　(25)　1-10　2021年12月2日

DOI： 10.1080/14767058.2021.2007238 　

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OBJECTIVE: We evaluated the relationship between prenatal folic acid supplementation and autism spectrum disorder (ASD) in 3-year-old offspring. METHODS: We used data from the Japan Environment and Children's Study, a nationwide prospective birth cohort study. We analyzed the data to determine the association between folic acid supplement use and the incidence of ASD in offspring, and classified participants into three groups based on the time of initiation of folic acid supplementation, as follows: (1) preconception users of folic acid supplements and (2) post-conception users, and (3) non-users. The dietary folate intake of study participants was also classified into three groups (<200 µg, 200 µg to <400 µg, ≥400 µg). RESULTS: Overall, 361 offspring of 96,931 participants with single pregnancies were diagnosed with ASD (0.37%). A total of 7,046 participants (7.3%) used folic acid supplements before conception, 29,984 (30.9%) took them after detection of pregnancy, and 59,901 (61.8%) never received them. Multivariate logistic regression analyses demonstrated no association between prenatal folic acid supplementation and ASD in offspring (preconception use: adjusted odds ratio [AOR], 1.189; 95% confidence interval [CI], 0.819-1.727 and post-conception use: AOR, 1.072; 95% CI, 0.840-1.368); additionally, no association was observed with the use of folic acid supplements and/or multivitamin supplements (preconception use: AOR, 1.273; 95% CI, 0.921-1.760 and post-conception use: AOR, 1.132; 95% CI, 0.885-1.449). Moreover, no significant association was observed in participants with combined prenatal supplement use and dietary folate intake. CONCLUSIONS: Maternal use of folic acid supplements from the pre- or post-conception period was not significantly associated with ASD in 3-year-old offspring in Japan. Evaluation of the dietary folate intake from preconception also showed no significant association.
Living environments long-term after the Great East Japan Earthquake and nutritional intake among recent mothers. 国際誌

Takahiro Yamashita, Keiko Murakami, Taku Obara, Yudai Yonezawa, Mami Ishikuro, Aoi Noda, Fumihiko Ueno, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

Asia Pacific journal of clinical nutrition　30　(4)　651-661　2021年12月

DOI： 10.6133/apjcn.202112_30(4).0012 　

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BACKGROUND AND OBJECTIVES: Although large-scale natural disasters and the resultant changes in living environments worsen dietary habits among adults immediately after the disasters, whether this association remains for a long period is unclear. This is particularly important for recent mothers because lactating women require additional nutrition for milk production. Thus, we investigated the association of living environments with dietary habits and nutritional intake of recent mothers between four and seven years after the Great East Japan Earthquake (11th March, 2011). METHODS AND STUDY DESIGN: We analyzed 8,551 mothers who participated to the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Living environments were characterized into four categories: "same home before the earthquake", "rental housing", "reconstructed home", and "acquaintance's home". Dietary habits and nutritional intake were evaluated using a food frequency questionnaire answered 12 months after their deliveries (the questionnaire was answered between March 2015 and July 2018). RESULTS: Multiple linear regression analyses demonstrated that mothers in 'rental housing' or 'reconstructed home' had a significantly lower intake of almost all nutrients or certain nutrients, respectively, compared with those residing in 'same home before the earthquake'. However, fewer significant differences were detected between the nutritional intake of the mothers lodging in an 'acquaintance's home' and that of those living in 'same home before the earthquake'. CONCLUSIONS: Our findings indicate that living environments long-term after largescale disasters are associated with dietary habits and nutritional intake among recent mothers.
Enhancement and evaluation of a prescription audit system for direct oral anticoagulants using a check sheet

Naoto Ishikawa, Hanae Oshikiri, Shinya Takasaki, Masafumi Kikuchi, Taku Obara, Kazutoshi Akasaka, Masaki Matsuura, Hiroaki Yamaguchi, Nariyasu Mano

Journal of Pharmaceutical Health Care and Sciences　7　(1)　2021年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/s40780-021-00205-y 　

eISSN：2055-0294

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<title>Abstract</title><sec> <title>Background</title> Renal function and use of concomitant medications should be carefully monitored in patients subjected to treatment with direct oral anticoagulants (DOACs); the dose should be individually designed for each patient. Owing to the complex therapeutic indications and dose reduction criteria, pharmacists exercise caution when determining the optimal dose for each patient. A DOAC check sheet has been developed that is automatically printed in the dispensing room at the same time as the prescription and can be used by pharmacists to dispense DOACs promptly and correctly. The purpose of this study was to evaluate the system for dispensing DOACs using a check sheet. </sec><sec> <title>Methods</title> The study was conducted at Tohoku University Hospital in Japan; prescriptions containing DOACs dispensed by the hospital pharmacists were evaluated. The DOAC check sheet described indications, dosage regimens, dose reduction criteria, and contraindications for each drug and included the patient’s information. The check sheet was set to print automatically in the dispensing room at the same time as the prescription when an inpatient was prescribed DOACs. This check sheet was evaluated using a prescription survey and a questionnaire for pharmacists. </sec><sec> <title>Results</title> The usefulness of this check sheet for the correct use of DOACs was evaluated. There were four inquiries out of 642 (0.6%) prescriptions from pharmacists to physicians regarding DOAC prescriptions, such as the dose introduced before DOAC check sheet utilization, and there were 21 out of 905 (2.3%) prescriptions when the DOAC check sheet was used it, showing a significant increase (<italic>p</italic> = 0.0089). After the introduction of this sheet, overdoses of DOACs were identified at the time of dispensing. Of the 52 pharmacists who responded to the questionnaire, 51 (98%) stated that the check sheet was useful. </sec><sec> <title>Conclusion</title> The use of the DOAC check sheet is likely to render safety to DOAC drug therapy for individual patients. </sec>
Impact of local vaccine subsidization programs on the prevention of mumps in Japan. 国際誌

Makoto Miyazaki, Taku Obara, Nariyasu Mano

Human vaccines & immunotherapeutics　17　(11)　4216-4224　2021年11月2日

DOI： 10.1080/21645515.2021.1974797 　

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In Japan, although a mumps vaccination is outside the national universal vaccination program, some local governments have implemented their own program. However, little is known regarding the implementation status and the impact of these programs. In this study, we investigated the impact on the prevention of mumps, after identification of the status of the local government subsidization programs. We identified the implementation status of the subsidization programs using the websites of local governments. We retrieved the number of reported mumps cases from designated sentinel sites through the Surveillance of Infectious Diseases System implemented according to the Infectious Disease Control Law. Using this data, the impact of the subsidization program on prevention of mumps was assessed by comparing the number of mumps cases per site during the 2015-2016 outbreak among the areas categorized by the subsidization status, using a Poisson regression model. As of 2019, 26.2% (456/1,739) of the local governments were considered as having subsidization programs. We retrieved 52,719 mumps cases from 2010 to 2019. The number of mumps cases per sentinel site tended to be low in areas implementing a subsidization program, compared with the no-implementation areas throughout the data collection period. The adjusted model confirmed that the subsidization program implemented between 2010 and 2015 impacted on the number of mumps cases during the 2015-2016 outbreak, with a decrease in the numbers. Further studies with detailed data including vaccination coverage should be conducted.
リアルワールドにおけるアンジオテンシンII受容体拮抗薬とジヒドロピリジン系Ca拮抗薬の腎機能への影響

佐藤倫広, 廣瀬卓男, 佐藤弘典, 中山晋吾, 小原拓, 村上任尚, 室谷智子, 浅山敬, 菊谷昌浩, 森建文, 今井潤, 大久保孝義, 目時弘仁

薬剤疫学　26　(Suppl.)　S133-S134　2021年11月
出版者・発行元： (一社)日本薬剤疫学会
ISSN：1342-0445

eISSN：1882-790X
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　80回　219-219　2021年11月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
リアルワールドにおけるアンジオテンシンII受容体拮抗薬とジヒドロピリジン系Ca拮抗薬の腎機能への影響

佐藤倫広, 廣瀬卓男, 佐藤弘典, 中山晋吾, 小原拓, 村上任尚, 室谷智子, 浅山敬, 菊谷昌浩, 森建文, 今井潤, 大久保孝義, 目時弘仁

薬剤疫学　26　(Suppl.)　S133-S134　2021年11月
出版者・発行元： (一社)日本薬剤疫学会
ISSN：1342-0445

eISSN：1882-790X
Maternal personality and alcohol use during pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

Addictive behaviors　122　107020-107020　2021年11月

DOI： 10.1016/j.addbeh.2021.107020 　

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BACKGROUND: Studies on associations between maternal personality and alcohol use have examined only one time point during pregnancy in Western countries. We aimed to examine the association between maternal personality and alcohol use in early and middle pregnancy in Japan. METHODS: We analyzed data from 17,144 pregnant women in Japan who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Personality was assessed using the short-form Eysenck Personality Questionnaire-Revised. Women were dichotomized as current drinkers or non-drinkers in both early and middle pregnancy. Odds ratios (ORs) and 95% confidence intervals (CIs) for alcohol use in early and middle pregnancy and continued alcohol use between early and middle pregnancy were calculated for 1 standard deviation increase in each personality scale, adjusted for age, as well as education, work status, fertility treatment, and parity. RESULTS: Higher extraversion scores were associated with alcohol use in early (OR, 1.16; 95% CI, 1.12-1.20) and middle pregnancy (OR, 1.17; 95% CI, 1.10-1.25). Higher psychoticism scores were associated with continued alcohol use into middle pregnancy (OR, 1.07; 95% CI, 1.01-1.14) and alcohol use in middle pregnancy (OR, 1.07; 95% CI, 1.02-1.13). Neuroticism was not associated with alcohol use in early or middle pregnancy. Lower lie was associated with alcohol use in early (OR, 0.95; 95% CI, 0.91-0.98), but not in middle pregnancy. CONCLUSIONS: Different personality scales are associated with alcohol use at different points during pregnancy.
Risk of major congenital malformations associated with first-trimester exposure to propulsives: A health administrative database study in Japan. 国際誌

Tomofumi Ishikawa, Taku Obara, Manabu Akazawa, Aoi Noda, Gen Oyanagi, Kei Morishita, Keiko Miyakoda, Hidekazu Nishigori, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Pharmacoepidemiology and drug safety　31　(2)　196-205　2021年10月10日

DOI： 10.1002/pds.5370 　

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PURPOSE: To evaluate the risk of major congenital malformations (MCMs) associated with first-trimester exposure to propulsives with a special focus on domperidone using a large administrative database in Japan. METHODS: A large claims database was used from January 2005 to August 2016. The dates of pregnancy onset and delivery were estimated using the developed algorithms. Major congenital malformations were defined according to the International Classification of Diseases, 10th revision codes. We compared the infants' risk of overall MCMs between women with or without first-trimester prescriptions of propulsives and estimated the odds ratios (ORs) with unadjusted and adjusted analyses. We also compared the risk of overall MCMs between women with domperidone prescriptions and those with other propulsive prescriptions during the first trimester. RESULTS: Among 38 270 women, propulsives were prescribed to 3197 women (8.4%) in the first trimester, including domperidone to 371 women (1.0%). Propulsive prescriptions in the first trimester were not significantly associated with an increased risk of overall MCMs (adjusted OR [aOR] 1.030, 95% confidence interval [CI] 0.843-1.257). Compared to the prescription of other propulsives in the first trimester, the prescription of domperidone in the first trimester was not associated with an increased risk of overall MCMs (aOR 0.724, 95% CI 0.363-1.447). CONCLUSIONS: The first-trimester prescription of propulsives, including domperidone, was not associated with an increased risk of overall MCMs. This article is protected by copyright. All rights reserved.
Augmentation method for convolutional neural network that improves prediction performance in the task of classifying primary lung cancer and lung metastasis using CT images

Takuma Usuzaki, Kengo Takahashi, Kazuma Umemiya, Mami Ishikuro, Taku Obara, Masahiro Kamimoto, Kazuhiro Majima

Lung Cancer　160　175-178　2021年10月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.lungcan.2021.06.021 　

ISSN：0169-5002
Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies. 国際誌

Naoki Nakaya, Tian Xie, Bart Scheerder, Naho Tsuchiya, Akira Narita, Tomohiro Nakamura, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Harold Snieder, Shinichi Kuriyama

Atherosclerosis　334　85-92　2021年10月

DOI： 10.1016/j.atherosclerosis.2021.08.037 　

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BACKGROUND AND AIMS: Few studies have examined and compared spousal concordance in different populations. This study aimed to quantify and compare spousal similarities in cardiometabolic risk factors and diseases between Dutch and Japanese populations. METHODS: This cross-sectional study included 28,265 Dutch Lifelines Cohort Study spouse pairs (2006-2013) and 5,391 Japanese Tohoku Medical Megabank Organization (ToMMo) Cohort Study pairs (2013-2016). Spousal similarities in cardiometabolic risk factors were evaluated using Pearson's correlation or logistic regression analyses adjusted for spousal age. RESULTS: The husbands' and wives' average ages in the Lifelines and ToMMo cohorts were 50.0 and 47.7 years and 63.2 and 60.4 years, respectively. Significant spousal similarities occurred with all cardiometabolic risk factors and diseases of interest in both cohorts. The age-adjusted correlation coefficients ranged from 0.032 to 0.263, with the strongest correlations observed in anthropometric traits. Spousal odds ratios [95% confidence interval] for the Lifelines vs. ToMMo cohort ranged from 1.45 (1.36-1.55) vs. 1.20 (1.05-1.38) for hypertension to 6.86 (6.30-7.48) vs. 4.60 (3.52-6.02) for current smoking. An increasing trend in spousal concordance with age was observed for sufficient physical activity in both cohorts. For current smoking, those aged 20-39 years showed the strongest concordance between pairs in both cohorts. The Dutch pairs showed stronger similarities in anthropometric traits and lifestyle habits (smoking and drinking) than their Japanese counterparts. CONCLUSIONS: Spouses showed similarities in several cardiometabolic risk factors among Dutch and Japanese populations, with regional and cultural influences on spousal similarities.
Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

2021年9月15日
出版者・発行元： Research Square Platform LLC
DOI： 10.21203/rs.3.rs-887730/v1 　

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<title>Abstract</title> ObjectiveThe aim of our study was to develop prediction model for preeclampsia (PE) using routinely examined items in early pregnancy especially dipstick test for proteinuria.MethodThe Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women and we included 9,086 of them in analysis. Maternal basic characteristics were obtained by self-report, and blood pressure and dipstick test of proteinuria were obtained by medical record at regular antenatal care. The outcome was defined as PE including superimposed preeclampsia. We developed prediction model without dipstick test of proteinuria (model 1) and model with it (model 2), and we compared them by the mean of area under the receiver operating characteristic curve (mAUROC) using five-fold cross validation.ResultsmAUROC of model 1 was 0.769 (95% CI; 0.741 to 0.797) and that of model 2 was 0.785 (95% CI; 0.758 to 0.812). The difference of two mAUROCs was 0.016 (95% CI; 0.004 to 0.028). In model 2, detection rates at false-positive rate of 5%, 10% and 20% were 40%, 49% and 64%, respectively.ConclusionsWe could develop prediction model for PE using routine antenatal care items and it was improved by including dipstick test for proteinuria.
Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis. 国際誌

Takafumi Yamauchi, Daisuke Ochi, Naomi Matsukawa, Daisuke Saigusa, Mami Ishikuro, Taku Obara, Yoshiki Tsunemoto, Satsuki Kumatani, Riu Yamashita, Osamu Tanabe, Naoko Minegishi, Seizo Koshiba, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi, Masayuki Yamamoto, Masao Nagasaki, Satoshi Hiyama, Junichi Sugawara

Scientific reports　11　(1)　17777-17777　2021年9月7日

DOI： 10.1038/s41598-021-97342-z 　

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The elucidation of dynamic metabolomic changes during gestation is particularly important for the development of methods to evaluate pregnancy status or achieve earlier detection of pregnancy-related complications. Some studies have constructed models to evaluate pregnancy status and predict gestational age using omics data from blood biospecimens; however, less invasive methods are desired. Here we propose a model to predict gestational age, using urinary metabolite information. In our prospective cohort study, we collected 2741 urine samples from 187 healthy pregnant women, 23 patients with hypertensive disorders of pregnancy, and 14 patients with spontaneous preterm birth. Using gas chromatography-tandem mass spectrometry, we identified 184 urinary metabolites that showed dynamic systematic changes in healthy pregnant women according to gestational age. A model to predict gestational age during normal pregnancy progression was constructed; the correlation coefficient between actual and predicted weeks of gestation was 0.86. The predicted gestational ages of cases with hypertensive disorders of pregnancy exhibited significant progression, compared with actual gestational ages. This is the first study to predict gestational age in normal and complicated pregnancies by using urinary metabolite information. Minimally invasive urinary metabolomics might facilitate changes in the prediction of gestational age in various clinical settings.
One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Saya Kikuchi, Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Natsuko Kobayashi, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Hiroaki Tomita

Journal of affective disorders　295　632-638　2021年9月4日

DOI： 10.1016/j.jad.2021.08.118 　

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BACKGROUND: Trajectories of postpartum depressive symptoms up to 1 year after childbirth and the related risk factors remain unclear. Accordingly, this study aimed to examine the 1-year trajectories of postpartum depressive symptoms and their associated risk factors. METHODS: A total of 22,493 pregnant women were recruited between July 2013 and September 2016 in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. Among them, 11,668 women with no missing data were included in the analyses. Depressive symptoms were assessed at 1 month and 1 year postpartum using the Edinburgh Postnatal Depression Scale. Multinominal logistic regression analysis was conducted after adjusting for covariates. RESULTS: The prevalence of depression was 13.9% at 1 month and 12.9% at 1 year postpartum. We identified four depression trajectories, i.e., "persistent (depressed throughout the 1 year postpartum)" (6.0%), "recovered (depressed at 1 month postpartum and recovered within a year)" (7.9%), "late-onset (became depressed after 1 month postpartum)" (6.8%), and "resilient (not depressed throughout 1 year postpartum)" (79.2%). Psychological distress during pregnancy was significantly associated with all trajectories (persistent: odds ratio [OR]=10.24, 95% confidence interval (CI)=8.40-12.48; recovered: OR=3.78, 95%CI=3.28-4.36; and late-onset: OR=3.96, 95%CI=3.40-4.62). LIMITATIONS: Postpartum depression was evaluated only by a self-administered questionnaire and the dropout rate was not neglectable. CONCLUSIONS: This study highlighted the high prevalence of depressive symptoms at 1 year postpartum and found that half of the depressive symptoms at 1 year were late-onset. The findings suggest the necessity of long-term follow-up (up to 1 year) for perinatal mental health.
東北メディカル・メガバンク計画三世代コホート調査の進捗報告

石黒真美, 小原拓, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 菊谷昌浩, 目時弘仁, 菅原準一, 栗山進一

DOHaD研究　9　(1)　28-28　2021年9月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
出生コホート連携に基づく胎児期から乳幼児期の環境と母児の予後との関連に関する研究

小原拓, 岸玲子, 佐田文宏, 清水厚志, 菅原準一, 土屋賢治, 堀川玲子, 目時弘仁, 森崎菜穂, 森千里, 栗山進一

DOHaD研究　9　(1)　77-77　2021年9月
出版者・発行元： (一社)日本DOHaD学会
ISSN：2187-2562

eISSN：2187-2597
662Factors associated with smoking continuation and indoor smoking among pregnant women’s partners

Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

International Journal of Epidemiology　50　(Supplement_1)　2021年9月1日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/ije/dyab168.464 　

ISSN：0300-5771

eISSN：1464-3685

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<title>Abstract</title> <sec> <title>Background</title> Secondhand smoke by partners is a major source of exposure for non-smoking women. However, factors associated with smoking continuation and indoor smoking among pregnant women’s partners remain unknown. </sec> <sec> <title>Methods</title> We used data from 6348 partners of non-smoking pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan from 2013 to 2017. Partners’ age, educational attainment, equivalent household income, and pregnant women’s smoking history (never, quitting before pregnancy awareness, quitting after pregnancy awareness) were used as explanatory variables. Multivariate logistic regression analyses were conducted to examine the associations between these variables and smoking continuation/indoor smoking of partners. </sec> <sec> <title>Results</title> Among 6348 partners, 2506 partners had been smokers at pregnancy awareness. Among them, the prevalence of smoking continuation after pregnancy awareness was 92.0%. Partners whose wives had quitted smoking after pregnancy awareness were less likely to continue smoking than partners whose wives had never smoked; the odds ratio was 0.57 (95% confidence interval, 0.41–0.80). Among partners who continued smoking, the prevalence of indoor smoking was 30.7%. Partners with ≤high school education were more likely to smoke indoors than partners with ≥university education; the odds ratio was 1.60 (95% confidence interval, 1.23–2.07). </sec> <sec> <title>Conclusions</title> Women’s smoking cessation after pregnancy awareness was associated with decreased risk of partners’ smoking continuation, and lower level of partners’ education was associated with increased risk of partners’ indoor smoking. </sec> <sec> <title>Key messages</title> Interventions for both women and their partners may be effective in reducing secondhand smoke exposure during pregnancy. </sec>
Limited consumption of 100% fruit juices and sugar sweetened beverages in Japanese toddler and preschool children. 国際誌

Janet M Wojcicki, Kenji J Tsuchiya, Keiko Murakami, Mami Ishikuro, Taku Obara, Naho Morisaki

Preventive medicine reports　23　101409-101409　2021年9月

DOI： 10.1016/j.pmedr.2021.101409 　

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Japanese toddler and preschool children, ages 1.5-5 years, have lower rates of obesity, ≥95 th percentile body mass index, compared with North American ones. We examined parental reported beverage consumption patterns in 3 Japanese based mother-child cohorts from three different regions of Japan compared with data from cross-sectional and longitudinal studies from North America. Specifically, we used data from the Hamamatsu Birth Cohort for Mothers and Children (HBC Study) in Hamamatsu (Shizuoka Prefecture), the Seiiku Boshi Birth Cohort from Setagaya, Tokyo and the TMM BirThree Cohort Study from Miyagi. We additionally compared cross-sectional data from preschoolers from 24 prefectures in Japan as previously reported from a national study. While Japanese children had lower but comparable rates to North American children for introduction of sugar-sweetened beverages and 100% fruit juices, Japanese children consumed these beverages daily at a much lower level than North American children. Additionally, North American children may get more added sugars from soda and fruit juices as a relative percentage of total added sugar. By contrast, Japanese children consume more sweetened dairy drinks as a relative percentage of total added sugar. Sweetened dairy drinks may have the added benefits of including fats, calcium and probiotics which may be associated with lower risk for obesity compared with consumption of other types of sugar sweetened beverages.
Hypertension in pregnancy as a possible factor for child autistic behavior at two years old. 国際誌

Mami Ishikuro, Keiko Murakami, Fumiya Yokozeki, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Taku Obara, Shinichi Kuriyama

Pregnancy hypertension　25　88-90　2021年8月

DOI： 10.1016/j.preghy.2021.05.020 　

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We investigated the association between hypertensive disorders of pregnancy (HDP) subtypes and child autistic behavior to accumulate the evidence. We found the association between superimposed preeclampsia and autistic behavior in children aged two years old by investigating 6794 mother-child pairs in the birth cohort study. Since early intervention for autism-spectrum disorder might be effective, it suggests that early prediction is necessary for children born of mothers who developed particularly superimposed preeclampsia to support their development. Not only for introducing early prediction, but also research for establishing effective intervention is necessary.
Trends in prescription of anti-seizure medicines for Japanese pediatric outpatients during 2013–2019

Daisuke Kikuchi, Taku Obara, Shota Kashiwagura, Youtaro Arima, Hiroaki Hino, Ryosuke Miura, Sachiko Hayakawa, Yoshiteru Watanabe

Epilepsy & Behavior Reports　100474-100474　2021年8月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.ebr.2021.100474 　

ISSN：2589-9864
Prescription status of diuretics for essential hypertension in a Japanese population

Daisuke Kikuchi, Misato Ito, Misaki Tokunaga, Kota Sasaki, Ryosuke Miura, Hiroyuki Hirakawa, Yuko Saito, Taku Obara, Yoshiteru Watanabe

Hypertension Research　2021年7月16日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-021-00688-0 　

ISSN：0916-9636

eISSN：1348-4214
Associations of education and work status with alcohol use and cessation among pregnant women in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

BMC public health　21　(1)　1400-1400　2021年7月15日

DOI： 10.1186/s12889-021-11461-w 　

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BACKGROUND: There is inconsistent evidence on the associations of education and work status with alcohol use during pregnancy. Our aim was to examine the associations of education and work status with alcohol use and alcohol cessation during pregnancy in Japan. METHODS: Data were analyzed from 11,839 pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017 in Japan. Women were dichotomized as current drinkers or non-drinkers in both early and middle pregnancy. Alcohol cessation was defined as alcohol use in early pregnancy, but not in middle pregnancy. Multivariable log-binomial regression analyses were conducted to examine associations of education and work status with alcohol use in early and middle pregnancy and alcohol cessation, adjusted for age and income. The prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated by work status and education. RESULTS: The prevalence of alcohol use in early and middle pregnancy was 20.9 and 6.4%, respectively. Higher education was associated with alcohol use in early pregnancy both among working and non-working women; the PRs of university education or higher compared with high school education or lower were 1.62 (95% CI, 1.34-1.96) and 1.29 (95% CI, 1.16-1.45), respectively. Higher education was associated with alcohol cessation during pregnancy among working women; the corresponding PR was 1.09 (95% CI, 1.01-1.17). Working was associated with alcohol use in early and middle pregnancy. Working was associated with a decreased probability of alcohol cessation among women with lower education but with an increased probability of alcohol cessation among women with higher education; the PRs of working compared with not working were 0.91 (95% CI, 0.82-1.00) and 1.10 (95% CI, 1.00-1.20), respectively. CONCLUSIONS: Women with higher education were more likely to consume alcohol in early pregnancy and to cease alcohol use between early and middle pregnancy, especially working women. Working women were more likely to consume alcohol throughout pregnancy. Working women with lower education were less likely to cease alcohol use, whereas working women with higher education were more likely to cease alcohol use between early and middle pregnancy.
Associations of education and income with hazardous drinking among postpartum women in Japan: results from the TMM BirThree Cohort Study. 国際誌

Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

Environmental health and preventive medicine　26　(1)　70-70　2021年7月3日

DOI： 10.1186/s12199-021-00991-9 　

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BACKGROUND: Although the postpartum period is suggested to provide an ideal opportunity for interventions to prevent hazardous drinking, evidence on the associations of education and income with hazardous drinking during this period is limited, including in Japan. METHODS: We analyzed data from 11,031 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. Hazardous drinking was defined as ethanol intake of ≥20 g/day 1 year after delivery. We conducted multiple logistic regression analyses to examine whether educational attainment or equivalent household income was associated with hazardous drinking, adjusting for age, parity, drinking status during pregnancy, work status, postpartum depression, breastfeeding, and income/education. We also conducted stratified analyses by income and education groups. RESULTS: The prevalence of hazardous drinking 1 year after delivery was 3.6%. Lower education was associated with hazardous drinking; the odds ratio (95% confidence interval) of high school education or lower compared with university education or higher was 2.17 (1.59-2.98). Lower income was also associated with hazardous drinking, but this association disappeared after further adjustments for education; the odds ratios (95% confidence intervals) of the lowest compared with highest level of income were 1.42 (1.04-1.94) and 1.12 (0.81-1.54), respectively. A significant interaction was detected; lower education and lower income were associated with increased risks of hazardous drinking only in a lower income group and lower education group, respectively. CONCLUSIONS: Postpartum women with lower education and lower income had higher risks of hazardous drinking in Japan.
Relation between disaster exposure, maternal characteristics, and obstetric outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Masahiro Kikuya, Junichi Sugawara, Hirohito Metoki, Shinichi Kuriyama

Journal of epidemiology　33　(3)　127-135　2021年7月3日

DOI： 10.2188/jea.JE20210052 　

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BACKGROUND: The study analyzed the relation between disaster exposure prior to pregnancy, maternal characteristics, and obstetric outcomes. METHODS: The participants were 13,148 pregnant women recruited from 2013 to 2017. The women were classified into three groups by the severity of housing damage caused by the Great East Japan Earthquake of 2011: group A, house was not destroyed/did not live in the disaster area; group B, half/part of the house was destroyed; and group C, house was totally/mostly destroyed. Maternal characteristics, hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), and gestational weeks were obtained by questionnaires and medical records. Multiple logistic regression analyses were performed to investigate the relation between disaster exposure and maternal characteristics, HDP, and GDM. A structural equation model was applied to investigate the relation between disaster exposure, and HDP and gestational weeks. RESULTS: The homes of about 11% of the women were totally/mostly destroyed. For groups B and C compared with those in group A, the adjusted ORs for HDP were 1.04 and 1.26 (P for trend = 0.01), and for GDM were 0.89 and 1.14 (P for trend = 0.9), respectively. Pre-pregnancy body mass index (BMI) mediated 23.2% of the relation between disaster exposure and HDP. Disaster exposure was associated with gestational weeks. CONCLUSION: Disaster exposure at least 2.5 years before pregnancy was found to be associated with maternal characteristics and the prevalence of HDP. Pre-pregnancy BMI mediated the relation between disaster exposure and the prevalence of HDP, and gestational weeks were reduced through HDP.
Identification of risk factors for mortality and delayed oral dietary intake in patients with open drainage due to deep neck infections: Nationwide study using a Japanese inpatient database 査読有り

Hiroshi Hidaka, Kunio Tarasawa, Kenji Fujimori, Taku Obara, Kiyohide Fushimi, Tomofumi Sakagami, Masao Yagi, Hiroshi Iwai

Head & Neck　2021年7月2日
出版者・発行元： Wiley
DOI： 10.1002/hed.26660 　
Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. 国際誌

Takumi Hirata, Mana Kogure, Naho Tsuchiya, Ken Miyagawa, Akira Narita, Kotaro Nochioka, Akira Uruno, Taku Obara, Tomohiro Nakamura, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　44　(7)　858-865　2021年7月

DOI： 10.1038/s41440-021-00628-y 　

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Recently, a high urinary sodium-to-potassium (Na/K) ratio and reduced sleep efficiency, in addition to conventional risk factors (obesity and excess alcohol intake), have been identified as risk factors for hypertension. We estimated the population attributable fraction (PAF) for home hypertension due to these risk factors in a general Japanese population. We conducted a cross-sectional study including 1384 participants (393 men and 991 women) to estimate the odds ratio (OR) and 95% confidence interval (CI) for the presence of any of the conventional risk factors using multivariable logistic regression analyses. The models were adjusted for sex, age, smoking status, and log-transformed average daily steps. We also estimated the OR and 95% CI for the presence of any of the overall risk factors. Furthermore, we calculated the PAF due to these risk factors. The results showed that the prevalence of home hypertension was 39.0% (540/1384). The presence of any of the conventional risk factors, as well as any of the overall risk factors, was significantly associated with an increased prevalence of hypertension (OR 2.80, 95% CI 2.15-3.65; OR 2.50, 95% CI 1.93-3.22, respectively). The PAF for hypertension due to the presence of any of the conventional risk factors and the PAF due to the presence of any of the overall risk factors were 30.2% and 39.0%, respectively. In conclusion, the impact of the overall risk factors, including the urinary Na/K ratio and sleep efficiency, on home hypertension was higher than that of conventional risk factors alone. The management of the urinary Na/K ratio and sleep efficiency as well as conventional risk factors might be important in the management of blood pressure.
Validity of congenital malformation diagnoses in healthcare claims from a university hospital in Japan

Tomofumi Ishikawa, Gen Oyanagi, Taku Obara, Aoi Noda, Kei Morishita, Shuyu Takagi, Ryusuke Inoue, Hiroshi Kawame, Nariyasu Mano

Pharmacoepidemiology and Drug Safety　30　(7)　975-978　2021年7月
出版者・発行元： Wiley
DOI： 10.1002/pds.5244 　

ISSN：1053-8569

eISSN：1099-1557
Grain consumption before and during pregnancy and birth weight in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

European journal of clinical nutrition　76　(2)　261-269　2021年6月15日

DOI： 10.1038/s41430-021-00939-w 　

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BACKGROUND/OBJECTIVES: Studies have reported the effects of grain consumption on human health, but the association between maternal grain consumption before and during pregnancy and birth weight remains unclear. We evaluated the association between maternal grain consumption before and during pregnancy and birth weight/low birth weight (LBW). SUBJECTS/METHODS: Grain consumption was calculated using two semi-quantitative food frequency questionnaires (FFQs). The two FFQs evaluated consumption from pre- to early pregnancy and then from early to mid-pregnancy, respectively. Information concerning birth weight was obtained from birth records, and multivariable analyses for birth weight and LBW risk were conducted after adjusting for potential confounders. RESULTS: In total, 17,610 pregnant women (age, 31.8 ± 4.9 years; smoked during pregnancy, 16.1%; gestation period, 38.5 ± 2.5 weeks; first childbirth, 45.5%) and their singleton and term new-borns (birth weight, 3061.8 ± 354.1 g; LBW, 5.4%) were included in the analysis. Women in the highest quartile of grain consumption from pre- to early pregnancy had heavier new-borns (β = 22.3; 95% confidence interval (CI): 5.8-38.9) but did not have a significantly lower LBW risk (odds ratio [OR]: 0.87; 95% CI: 0.71-1.07) than women in the lowest quartile. Women in the highest quartile of grain consumption from early to mid-pregnancy also had heavier new-borns (β = 24.1; 95% CI: 7.1-41.1) but did not have a significantly lower LBW risk (OR: 0.85; 95% CI: 0.69-1.05) than women in the lowest quartile. CONCLUSIONS: Grain consumption before and during pregnancy was positively associated with birth weight.
Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in Japan. 国際誌

Yudai Yonezawa, Fumihiko Ueno, Taku Obara, Takahiro Yamashita, Mami Ishikuro, Keiko Murakami, Aoi Noda, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

The British journal of nutrition　127　(8)　1-9　2021年6月14日

DOI： 10.1017/S0007114521002154 　

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The association between fruit and vegetable consumption before and during pregnancy and offspring's physical growth has been well reported, but no study has focused on offspring's neurological development. We aimed to explore the association between maternal fruit and vegetable consumption before and during pregnancy and developmental delays in their offspring aged 2 years. Between July 2013 and March 2017, 23 406 women were recruited for the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Fruit and vegetable consumption was calculated using FFQ, and offspring's developmental delays were evaluated by the Ages & Stages Questionnaires, Third Edition (ASQ-3) for infants aged 2 years. Finally, 10 420 women and 10 543 infants were included in the analysis. Totally, 14·9 % of children had developmental delay when screened using the ASQ-3. Women in the highest quartile of vegetable consumption from pre-pregnancy to early pregnancy and from early to mid-pregnancy had lower odds of offspring's developmental delays (OR 0·74; 95 % CI 0·63, 0·89 and OR 0·70; 95 % CI 0·59, 0·84, respectively) than women in the lowest quartile. Women in the highest quartile of fruit consumption from early to mid-pregnancy had lower odds of offspring's developmental delays (OR 0·78; 95 % CI 0·66, 0·92) than women in the lowest quartile. In conclusion, high fruit and vegetable consumption before and during pregnancy was associated with a lower risk of developmental delays in offspring aged 2 years.
Evaluation of the Safety of Taking Lamotrigine During Lactation Period. 国際誌

Kazushi Yashima, Taku Obara, Fumiko Matsuzaki, Chihiro Suzuki, Mika Saeki, Mina Koyama, Moeko Hosono, Aoi Noda, Saya Kikuchi, Tetsuro Hoshiai, Shinichi Sato, Masatoshi Saito, Takushi Hanita, Nariyasu Mano

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine　16　(5)　432-438　2021年5月

DOI： 10.1089/bfm.2020.0210 　

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Introduction: Evaluation of the safety of taking lamotrigine (LTG) during lactation in breastfed infants varies according to the information sources. As it is possible that prescribers may avoid prescribing LTG despite of it being one of the essential drugs, more information needs to be accumulated to facilitate its use. Materials and Methods: We retrospectively compared the safety of LTG during the lactation period in 20 pairs of mothers and infants with 20 pairs as the control group. Results: The mean dose of LTG in 20 mothers was 161.1 mg/day (range: 50-400 mg/day). None of the infants showed a neonatal withdrawal syndrome score of 2 or more up to 1 month after delivery. Although drowsiness (n = 3), skin rash (n = 11), jaundice (n = 8), heart murmur (n = 1), poor suckling (n = 1), and retractive breathing (n = 1) were observed in infants, none of these adverse events were serious and the infants recovered. Nineteen of 20 pairs could continue lactation until 1 month after delivery. One pair discontinued breastfeeding because of pain in the mother's nipples. All pairs could continue maternal medication. We then compared the results with those of the control group. There were no significant differences in the presence of adverse events between the LTG and control groups. Conclusion: These data suggest that taking low to moderate doses of LTG during the lactation period might be relatively safe, at least for a period of 1 month after delivery.
Real-world anticancer medications for reproductive-age women with breast cancer by using a claims database in Japan. 国際誌

Kentaro Tajima, Masami Tsuchiya, Tomofumi Ishikawa, Taku Obara, Nariyasu Mano

Future oncology (London, England)　17　(15)　1907-1921　2021年5月

DOI： 10.2217/fon-2020-1053 　

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Aim: To describe real-world breast cancer medications among reproductive-age women. Patients & methods: Using data from a Japanese claims database, anticancer prescriptions were classified into seven categories of amenorrhea risk based on fertility preservation guidelines. Results: We identified 2999 women with records of breast cancer and anticancer prescription from 2005 to 2018. The proportions of prescriptions were as follows: high, 4.1-12.9%; intermediate: 6.0-16.3%; low: 0.4-2.3%; very low/no: 0.3-12.2%; unknown: 33.9-45.5%; unlisted combination: 12.2-23.4%; and unlisted drug: 12.5-26.7%. The common drugs in the unknown category were trastuzumab (n = 1527), docetaxel (n = 1014), and paclitaxel (n = 995). For medications unlisted in the guidelines, various drugs and drug combinations were observed. Conclusion: Numerous anticancer drugs are currently being prescribed with insufficient evidence regarding amenorrhea risk.
Factors associated with postpartum smoking relapse among women who quit in early pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

Journal of epidemiology　33　(1)　8-14　2021年4月28日

DOI： 10.2188/jea.JE20200609 　

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BACKGROUND: While a wide range of predictors of postpartum smoking relapse have been suggested, population-based studies have rarely examined these factors exclusively among women who quit in early pregnancy. Furthermore, workplace secondhand smoke (SHS) exposure has never been examined. METHODS: We analyzed data from 10,466 pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Age, education, parity, breastfeeding, postpartum depression, SHS exposure at home, and SHS exposure at work (not working, working without SHS exposure, working with SHS exposure) were evaluated as possible predictors. Multiple logistic regression analyses were conducted to examine the associations between these factors and smoking relapse by 1 year postpartum among women who quit in early pregnancy. Analyses stratified by SHS exposure at home were also conducted. RESULTS: About one-fourth of early-pregnancy quitters had relapsed into smoking by 1 year postpartum. Lower education, multiparity, not breastfeeding, postpartum depression, and SHS exposure at home were associated with increased risks of smoking relapse. Working with SHS exposure was associated with an increased risk of smoking relapse; the multivariate-adjusted odds ratios (95% confidence intervals) of working without SHS exposure and working with SHS exposure compared with not working were 1.14 (0.82-1.59) and 2.18 (1.37-3.46), respectively. The significant association of workplace SHS exposure was observed only among women without SHS exposure at home. CONCLUSIONS: SHS exposure at work, as well as education, multiparity, breastfeeding, postpartum depression, and SHS exposure at home were associated with postpartum smoking relapse among early-pregnancy quitters.
High-quality reports and their characteristics in the Japanese Adverse Drug Event Report database (JADER)

Masami Tsuchiya, Taku Obara, Makoto Miyazaki, Aoi Noda, Takamasa Sakai, Ryohkan Funakoshi, Nariyasu Mano

Journal of Pharmacy & Pharmaceutical Sciences　24　161-173　2021年4月8日
出版者・発行元： University of Alberta Libraries
DOI： 10.18433/jpps31417 　

eISSN：1482-1826

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Purpose: Spontaneous adverse drug reaction reporting is the foundation of postmarketing drug safety monitoring. The present study aimed to analyze and clarify the quality and characteristics of the Japanese Adverse Drug Event Report database (JADER) using the World Health Organization (WHO) documentation grading scheme and the vigiGrade completeness score. The characteristics of reports were described using both schemes simultaneously. The way of proper use of these two schemes was explored. Methods: The WHO documentation grading scheme and the vigiGrade completeness score were applied to the same dataset (JADER202001 dataset). Reports classified as high-quality under both assessment criteria were extracted, and the characteristics of these reports were analyzed. Results: Of the 607,361 adverse drug reaction reports analyzed, 52.8% were ‘well-documented reports’ with a vigiGrade completeness score >0.8. Under the WHO documentation grading scheme, 328,702 reports (54.1%) were Grade 2 and 5,178 (0.9%) were Grade 3 (including rechallenge information). Among well-documented Grade 3 reports, classified as the highest quality, a high proportion of the adverse drug reaction reports were related to disorders of hematopoietic function resulting from anticancer drugs. Because a high proportion of the reports with rechallenge information were for anticancer drugs as suspect drugs, the WHO documentation grading scheme tended to extract reports regarding anticancer drugs as high quality. Conclusions: We conclude that the two schemes need to be used appropriately, depending on the purpose of analysis, the target adverse drug reactions, and suspect drugs.
The impact of regulation changes in the spontaneous reporting system for vaccines on reporting trends and signal detection in Japan. 国際誌

Makoto Miyazaki, Takamasa Sakai, Taku Obara, Nariyasu Mano

Pharmacoepidemiology and drug safety　30　(8)　1091-1100　2021年3月17日

DOI： 10.1002/pds.5231 　

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PURPOSE: Spontaneous reporting constitutes one of the most fundamental and important systems for pharmacovigilance. In Japan, important regulation changes in the vaccine spontaneous reporting were implemented between 2009 and 2013; however, no studies had yet assessed the impact of the changes. The objective of this study was to assess the impact on the reporting trends in vaccine reports and on signal detection for vaccines. METHODS: For assessment of the impact on the reporting trends, we performed the joinpoint trend analysis and descriptively considered number of vaccine reports grouped by the timing of the regulation change. For assessment of the impact on signal detection, we performed signal detection using dataset during the pre or postperiod of the regulation changes, and compared their agreement rates, which was calculated with a reference set for vaccines, created by the Global Research in Paediatrics project. RESULTS: We retrieved 467 635 spontaneous reports, including 12 287 vaccine reports from April 2004 to March 2019. The average number of vaccine reports per year increased from 231 reports during the preperiod to 1227 during the postperiod. The joinpoint trend analysis found two joinpoints and differentiated three trends, significant increased trend of which was observed when regulations had changed. For signal detection, the agreement rate was improved when using data during the postperiod. CONCLUSION: We concluded that the regulation changes increased the number of vaccine reports, and could have improved signal detection performance for vaccines by accelerating accumulation of reports, while more spontaneous reports are necessary to optimize signal detection.
危機管理計画に基づく医薬品副作用モニタリングシステムの実施(Implementation of an Adverse Drug Reaction Monitoring System Based on Risk Management Plans)

Tsuchiya Masami, Esashi Akihisa, Obara Taku, Funakoshi Ryohkan, Mano Nariyasu

医薬品相互作用研究　45　(1)　19-26　2021年3月
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
Maternal personality and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Keiko Murakami, Fumihiko Ueno, Ibuki Nakamura, Mami Ishikuro, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

Journal of affective disorders　282　580-586　2021年3月1日

DOI： 10.1016/j.jad.2020.12.187 　

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BACKGROUND: Despite much knowledge of the effects of maternal psychopathology on bonding, the effects of personality have received less attention. We aimed to examine the association between maternal personality and postnatal bonding disorder. METHODS: We analyzed data from 15,654 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised, with the score for each subscale categorized into four levels. Bonding disorder was defined as the Mother-to-Infant Bonding Scale score of ≥5 one month after delivery. Multiple logistic regression analyses were conducted to examine the association between personality and bonding disorder after adjusting for age, education, parity, feelings towards pregnancy, social isolation, as well as the Edinburgh Postpartum Depression Scale (EPDS) score. RESULTS: Higher extraversion was associated with a decreased risk of bonding disorder (p for trend <0.001). Higher neuroticism was associated with an increased risk of bonding disorder (p for trend <0.001), and this association disappeared after further adjustment for EPDS score (p for trend 0.39). No association between psychoticism and bonding disorder was observed (p for trend 0.83), and the association appeared after further adjustment for EPDS score (p for trend 0.0017). Higher lie was associated with a decreased risk of bonding disorder (p for trend <0.001). LIMITATIONS: Maternal personality and bonding were self-reported. CONCLUSIONS: Lower extraversion, higher psychoticism, and lower lie were associated with bonding disorder. The association between higher neuroticism and bonding disorder was explained by postnatal depressive symptoms.
The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake. 国際誌

Kaou Tanoue, Zen Watanabe, Hidekazu Nishigori, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Kousuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Environmental health and preventive medicine　26　(1)　27-27　2021年2月26日

DOI： 10.1186/s12199-021-00944-2 　

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BACKGROUND: To examine changes in psychological distress prevalence among pregnant women in Miyagi Prefecture, which was directly affected by the Great East Japan Earthquake and tsunami, and compare it with the other, less damaged areas of Japan. METHODS: This study was conducted in conjunction with the Japan Environment and Children`s Study. We examined 76,152 pregnant women including 8270 in Miyagi Regional Center and 67,882 in 13 other regional centers from the all-birth fixed data of the Japan Environment and Children's Study. We then compared the prevalence and risk of distress in women in Miyagi Regional Center and women in the 13 regional centers for 3 years after the disaster. RESULTS: Women in the Miyagi Regional Center suffered more psychological distress than those in the 13 regional centers: OR 1.38 (95% CI, 1.03-1.87) to 1.92 (95% CI, 1.42-2.60). Additionally, women in the inland area had a consistently higher prevalence of psychological distress compared to those from the 13 regional centers: OR 1.67 (95% CI, 1.18-2.38) to 2.19 (95% CI, 1.60-2.99). CONCLUSIONS: The lack of pre-disaster data in the Japan Environment and Children's Study made it impossible to compare the incidence of psychological distress before and after the March 2011 Great East Japan Earthquake. However, 3 years after the Great East Japan Earthquake, the prevalence of pregnant women with psychological distress did not improve in Miyagi Regional Center. Further, the prevalence of mental illness in inland areas was consistently higher than that in the 13 regional centers after the disaster.
全国大学医学部における医薬品・医療機器等安全性情報報告制度に関わる授業内容の実態

佐藤倫広, 目時弘仁, 堀里子, 小原拓, 眞野成康

日本臨床薬理学会学術総会抄録集　42　2-P-O-3　2021年
出版者・発行元：一般社団法人日本臨床薬理学会
DOI： 10.50993/jsptsuppl.42.0_2-p-o-3 　

eISSN：2436-5580

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【目的】医薬品・医療機器等安全性情報報告制度（以下、本制度）により、医薬関係者は医薬品等によって発生する健康被害等の情報を厚生労働大臣に報告することとされている。全ての医療機関及び薬局等が対象であるが、医薬品の国内副作用・感染症症例報告に占める医療機関報告は少ない。本制度の理解度が副作用等報告の経験に強く関連するという先行研究から、大学生時代における教育が重要と考えられるが、医学部における教育実態は明らかではない。本研究では、全国の医学部を有する大学を対象に、本制度に関わる授業を明らかにすることを目的とした。 【方法】本研究は、医薬品等規制調和・評価研究事業（AMED）『医薬関係者による副作用報告の質向上に向けた情報連携のあり方の研究（代表：眞野成康）』の一環として実施された。全国の医学部を有する大学に、電話、メール、ホームページからの問い合わせ、または紙媒体の郵送により調査を依頼し、本制度に関わる授業科目とその内容、および自由記載により本制度の医学教育における改善点と意見を収集した。 【結果・考察】全82大学のうち25大学から当該授業科目の内容が回答された。その他、11大学から該当する授業がない旨の回答、4大学から回答拒否、および42大学からは未回答（現在郵送調査による再依頼中）であった。本制度に関わる講義をした科目は、薬理学が9件、臨床薬理学・薬物治療学が8件、衛生学・公衆衛生学が5件、医療安全・管理学が5件と多く、概論や実習を含むその他25件の科目も挙げられた。これら授業のコマ数を各大学で集計した結果、授業コマ数は1～2コマが17大学と最も多かった。履修学年は4年次が最も多く、5年次以上で回答された科目を実施している大学は3大学のみであった。医薬品安全性情報報告書を実際に「記載させる」と回答した科目は1件のみであった。意見の自由記載欄では、副作用発生の臨床薬理学的なバックグラウンドや薬害歴史の理解の重要性に言及した回答が比較的多く見られ、その他、報告に関わる実習の増加、医学部コアカリキュラムの改定、または5～6年や卒後の教育の充実などが具体的な提案として挙げられた。 【結論】医学部における本制度の講義は、主に薬理学および臨床薬理学・薬物治療学で実施されていた。実際に報告を経験させる授業は限られており、また、5～6年次における授業も不十分と考えられた。
Heart Rate Information-Based Machine Learning Prediction of Emotions Among Pregnant Women. 国際誌

Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

Frontiers in psychiatry　12　799029-799029　2021年

DOI： 10.3389/fpsyt.2021.799029 　

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In this study, the extent to which different emotions of pregnant women can be predicted based on heart rate-relevant information as indicators of autonomic nervous system functioning was explored using various machine learning algorithms. Nine heart rate-relevant autonomic system indicators, including the coefficient of variation R-R interval (CVRR), standard deviation of all NN intervals (SDNN), and square root of the mean squared differences of successive NN intervals (RMSSD), were measured using a heart rate monitor (MyBeat) and four different emotions including "happy," as a positive emotion and "anxiety," "sad," "frustrated," as negative emotions were self-recorded on a smartphone application, during 1 week starting from 23rd to 32nd weeks of pregnancy from 85 pregnant women. The k-nearest neighbor (k-NN), support vector machine (SVM), logistic regression (LR), random forest (RF), naïve bayes (NB), decision tree (DT), gradient boosting trees (GBT), stochastic gradient descent (SGD), extreme gradient boosting (XGBoost), and artificial neural network (ANN) machine learning methods were applied to predict the four different emotions based on the heart rate-relevant information. To predict four different emotions, RF also showed a modest area under the receiver operating characteristic curve (AUC-ROC) of 0.70. CVRR, RMSSD, SDNN, high frequency (HF), and low frequency (LF) mostly contributed to the predictions. GBT displayed the second highest AUC (0.69). Comprehensive analyses revealed the benefits of the prediction accuracy of the RF and GBT methods and were beneficial to establish models to predict emotions based on autonomic nervous system indicators. The results implicated SDNN, RMSSD, CVRR, LF, and HF as important parameters for the predictions.
Prescription of Kampo Formulations for Pre-natal and Post-partum Women in Japan: Data From an Administrative Health Database. 国際誌

Satoko Suzuki, Taku Obara, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Ryutaro Arita, Minoru Ohsawa, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

Frontiers in nutrition　8　762895-762895　2021年

DOI： 10.3389/fnut.2021.762895 　

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Introduction: Traditional Japanese (Kampo) medicines are often prescribed for women in Japan before, during, and after pregnancy. However, detailed information on the actual frequency of use and safety of Kampo preparations during pregnancy is lacking. Aim: To investigate the frequency of prescription of Kampo medicines for pregnant women in Japan. Methods: Information on Kampo medicines prescribed during outpatient care and hospitalization of selected mothers from January 2005 to August 2016 were extracted from the Japan Medical Data Center (Tokyo, Japan), which is a large claims database. Results: Of the 33,941 subscribers identified from the database, 16,294 (48%) received at least one prescription of a Kampo medicine. Kakkonto was the formula most prescribed during the study period, followed by shoseiryuto and tokishakuyakusan. In the 180 days before pregnancy, the most prescribed medicine was tokishakuyakusan, followed by kakkonto and shoseiryuto. Shoseiryuto, tokishakuyakusan, and kakkonnto were the formulae most prescribed during pregnancy. The most prescribed medicines during the 180 days postpartum were kakkonto, shoseiryuto, and saireito. Conclusions: Information in the Japanese insurance system shows that Kampo medicines are often prescribed during pregnancy. Most of these prescriptions are generally used for the treatment of common cold. Tokishakuyakusan in particular is usually used in the treatment of various symptoms of pregnancy. Further research is needed to clarify the relationship between the use of Kampo medicines during pregnancy and adverse events in infants in Japan.
児の先天奇形に関するレセプト傷病名の妥当性評価

石川智史, 小原拓, 大柳元, 野田あおい, 森下啓, 高木秀侑, 井上隆輔, 川目裕, 眞野成康

Journal of Epidemiology　31　(Suppl.)　131-131　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
両親と児の血圧値の関連についての横断的検討三世代コホート調査

石黒真美, 小原拓, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 目時弘仁, 菊谷昌浩, 栗山進一

Journal of Epidemiology　31　(Suppl.)　101-101　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画三世代コホート調査の進捗

小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 菊谷昌浩, 目時弘仁, 栗山進一

Journal of Epidemiology　31　(Suppl.)　105-105　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
妊娠前および妊娠中の穀物摂取量と出生時体重・低出生体重三世代コホート調査

米沢祐大, 小原拓, 山下貴宏, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 菅原準一, 鈴木重徳, 菅沼大行, 栗山進一

Journal of Epidemiology　31　(Suppl.)　95-95　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画地域住民コホート特定健診共同参加型対象者の基礎特性とがん罹患の関連

寳澤篤, 小原拓, 中村智洋, 板橋芙美, 小暮真奈, 成田暁, 土屋菜歩, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 布施昇男, 辻一郎, 呉繁夫

Journal of Epidemiology　31　(Suppl.)　116-116　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Small for gestational age児を予測するリスクスコアの検討三世代コホート調査

岩間憲之, 小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 星合哲郎, 齋藤昌利, 目時弘仁, 菅原準一, 八重樫伸生, 栗山進一

Journal of Epidemiology　31　(Suppl.)　130-130　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画三世代コホート調査母子のベースライン調査プロファイル

菅原準一, 石黒真美, 大沼ともみ, 村上慶子, 上野史彦, 野田あおい, 菊谷昌浩, 目時弘仁, 小原拓, 栗山進一

Journal of Epidemiology　31　(Suppl.)　131-131　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Active Extraction of Experience of Adverse Drug Reactions in Children. 国際誌

Aoi Noda, Taku Obara, Michihiro Satoh, Naoto Yagi, Nariyasu Mano, Kenji Kaneko

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG　26　(4)　352-360　2021年

DOI： 10.5863/1551-6776-26.4.352 　

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OBJECTIVE: Safety information regarding the use of medication, over-the-counter drugs, and supplements for Japanese children is scarce. The aim of this study was to clarify adverse drug reaction (ADR) experiences in children and consider the method to collect ADRs efficiently. METHODS: We conducted a questionnaire survey regarding the ADR experiences of 20,412 children who were attending a preschool or kindergarten in the cities of Warabi and Toda, Saitama Prefecture, in May 2013. RESULTS: Responses were received from the guardians of 15,076 children (49.5% girls; 8.2 ± 3.5 yr). A total of 196 guardians (1.3%) responded that their children had experienced ADRs. Among them, a total of 243 suspected drugs and 284 ADRs were reported. Of the 243 suspected drugs, 2.5% were associated with a vaccine. The most frequently reported medication, reaction, and "medication-reaction pair" were antibacterials for systemic use, rash, and "antibacterials for systemic use and rash," respectively. CONCLUSIONS: In this study, we clarified that there were many potential ADRs among children, but all "medication-reaction pairs" reported were consistent with adverse events reported in the clinical trials available in the prescribing information of each medication. This study provides data respective to the frequency of these adverse events in the general pediatric population. Additional education is needed to enlighten guardians of the importance to report ADRs through the Direct Patient Reporting System.
妊娠前および妊娠中の穀物摂取量と出生時体重・低出生体重三世代コホート調査

米沢祐大, 小原拓, 山下貴宏, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 菅原準一, 鈴木重徳, 菅沼大行, 栗山進一

Journal of Epidemiology　31　(Suppl.)　95-95　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画地域住民コホート特定健診共同参加型対象者の基礎特性とがん罹患の関連

寳澤篤, 小原拓, 中村智洋, 板橋芙美, 小暮真奈, 成田暁, 土屋菜歩, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 布施昇男, 辻一郎, 呉繁夫

Journal of Epidemiology　31　(Suppl.)　116-116　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Small for gestational age児を予測するリスクスコアの検討三世代コホート調査

岩間憲之, 小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 星合哲郎, 齋藤昌利, 目時弘仁, 菅原準一, 八重樫伸生, 栗山進一

Journal of Epidemiology　31　(Suppl.)　130-130　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画三世代コホート調査母子のベースライン調査プロファイル

菅原準一, 石黒真美, 大沼ともみ, 村上慶子, 上野史彦, 野田あおい, 菊谷昌浩, 目時弘仁, 小原拓, 栗山進一

Journal of Epidemiology　31　(Suppl.)　131-131　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
児の先天奇形に関するレセプト傷病名の妥当性評価

石川智史, 小原拓, 大柳元, 野田あおい, 森下啓, 高木秀侑, 井上隆輔, 川目裕, 眞野成康

Journal of Epidemiology　31　(Suppl.)　131-131　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Adverse Drug Reaction Reports Regarding Abnormal Behavior After Oseltamivir Use in Children as Reported by Consumers or Healthcare Professionals. 国際誌

Aoi Noda, Masami Tsuchiya, Takamasa Sakai, Taku Obara, Nariyasu Mano

Patient preference and adherence　15　533-541　2021年

DOI： 10.2147/PPA.S292072 　

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Purpose: The purpose of this study was to assess the differences between consumer (patient) and healthcare professional submissions of adverse drug reaction (ADR) reports associated with certain antiviral treatments in children. Material and Methods: We extracted ADR reports for children aged <20 years who received oseltamivir or similar drugs (zanamivir and amantadine) between April 2004 and May 2020 from the Japanese Adverse Drug Event Report database. Abnormal behavior after oseltamivir administration was reported frequently in the news in November 2005, and a Dear Healthcare Professional letter about abnormal behavior after oseltamivir use was issued on March 20, 2007. We compared the number of ADR reports by three periods: (1) before the news, (2) between the news and the letter, and (3) after the letter. These reports were tabulated and analyzed after stratification according to the reporter (healthcare professionals only, patients and healthcare professionals, patients only), patient age (<10 years, 10-19 years), and ADR (abnormal behavior, other ADRs). Results: For the reports from healthcare professionals only, the number of reports per quarter associated with oseltamivir was largest during the period between the news about abnormal behavior after oseltamivir use and publication of the Dear Healthcare Professional letter. The reports from patients only about abnormal behavior after oseltamivir use were first reported after publication of the letter. The proportions of reports from patients only about abnormal behavior with oseltamivir were 81.0% and 92.2% for ages <10 and 10-19 years, respectively. A ripple effect of increasing reports was observed with zanamivir or amantadine. Conclusion: Reports from patients only might increase in response to the media more than reports from healthcare professionals only or patients and healthcare professionals do. The ADR reports from patients must be carefully assessed from the perspective of when they were reported.
Drug Prescription for Attention Deficit Hyperactivity Disorder Drugs in Pediatric Outpatients: A Retrospective Survey of Japanese Administrative Data (2012–2018)

Daisuke Kikuchi, Taku Obara, Misaki Tokunaga, Makoto Shiozawa, Ai Takahashi, Misato Ito, Hiroaki Hino, Ryosuke Miura, Sachiko Hayakawa, Yoshiteru Watanabe

Asian Journal of Psychiatry　102512-102512　2021年1月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.ajp.2020.102512 　

ISSN：1876-2018
Clustering by phenotype and genome-wide association study in autism 査読有り

Akira Narita, Masato Nagai, Satoshi Mizuno, Soichi Ogishima, Gen Tamiya, Masao Ueki, Rieko Sakurai, Satoshi Makino, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Hiroko Matsubara, Yasutaka Kuniyoshi, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomoko Kobayashi, Mika Kobayashi, Takuma Usuzaki, Hisashi Ohseto, Atsushi Hozawa, Masahiro Kikuya, Hirohito Metoki, Shigeo Kure, Shinichi Kuriyama

Translational Psychiatry　10　(1)　2020年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41398-020-00951-x 　

eISSN：2158-3188

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<title>Abstract</title>Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have more power to elucidate hidden heritability. We conducted cluster analyses using the k-means algorithm with a cluster number of 15 based on phenotypic variables from the Simons Simplex Collection (SSC). As a preliminary study, we conducted a conventional genome-wide association study (GWAS) with a data set of 597 ASD cases and 370 controls. In the second step, we divided cases based on the clustering results and conducted GWAS in each of the subgroups vs controls (cluster-based GWAS). We also conducted cluster-based GWAS on another SSC data set of 712 probands and 354 controls in the replication stage. In the preliminary study, which was conducted in conventional GWAS design, we observed no significant associations. In the second step of cluster-based GWASs, we identified 65 chromosomal loci, which included 30 intragenic loci located in 21 genes and 35 intergenic loci that satisfied the threshold of <italic>P</italic> < 5.0 × 10⁻⁸. Some of these loci were located within or near previously reported candidate genes for ASD: <italic>CDH5</italic>, <italic>CNTN5, CNTNAP5, DNAH17, DPP10, DSCAM</italic>, <italic>FOXK1</italic>, <italic>GABBR2, GRIN2A</italic>5, <italic>ITPR1, NTM, SDK1, SNCA</italic>, and <italic>SRRM4</italic>. Of these 65 significant chromosomal loci, rs11064685 located within the <italic>SRRM4</italic> gene had a significantly different distribution in the cases vs controls in the replication cohort. These findings suggest that clustering may successfully identify subgroups with relatively homogeneous disease etiologies. Further cluster validation and replication studies are warranted in larger cohorts.
Commentary on “Determinants of pre‐eclampsia among pregnant women attending perinatal care in hospitals of the Omo district, Southern Ethiopia”

Takuma Usuzaki, Mami Ishikuro, Taku Obara

The Journal of Clinical Hypertension　23　(1)　163-165　2020年11月21日
出版者・発行元： Wiley
DOI： 10.1111/jch.14110 　

ISSN：1524-6175

eISSN：1751-7176
Comparison among research, home, and office blood pressure measurements for pregnant women: The TMM BirThree Cohort Study. 国際誌

Takuma Usuzaki, Mami Ishikuro, Hirohito Metoki, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Masahiro Kikuya, Taku Obara, Shinichi Kuriyama

Journal of clinical hypertension (Greenwich, Conn.)　22　(11)　2004-2013　2020年11月

DOI： 10.1111/jch.14050 　

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Blood pressure (BP) measurements of pregnant women have been collected in offices and at home for previous research. However, it remains uncertain whether there is difference between research BP, defined as BP measured for the purpose of epidemiological research and BP measured at home or in an office. Therefore, the present study aimed to compare research BP with home and unstandardized office BP. Research, home, and office BP were measured among pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). Research BP was measured twice at our research center while the participant was seated and after resting for 1-2 minutes. Research, home, and office BP were compared and agreement among the values was assessed. Differences among research, home, and office BP values and possible factors affecting differences were analyzed. Among 656 pregnant women, the mean (± standard deviations) research systolic (S), diastolic (D) BP, home SBP, home DBP office SBP, and office DBP were 103.8 ± 8.5, 61.8 ± 7.3, 104.4 ± 9.2, 61.2 ± 6.8, 110.5 ± 10.8, and 63.8 ± 8.7mmHg, respectively. Research SBP value was lower than home value (P = .0072; difference between mean research and home BP: -0.61 ± 7.8 mmHg). Research SBP and DBP values were lower than office values (P < .0001 for both SBP and DBP; means ± standard deviations of differences between research and office BP: 6.7 ± 10.1 and 2.0 ± 8.5 mmHg for SBP and DBP, respectively). In conclusion, when research BP is measured under conditions controlled, research BP can give close values to home BP for pregnant women.
Associations between glycosylated hemoglobin level at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan: The Japan Environment and Children's Study (JECS). 国際誌

Noriyuki Iwama, Takashi Sugiyama, Hirohito Metoki, Masatoshi Saito, Tetsuro Hoshiai, Zen Watanabe, Kosuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hidekazu Nishigori, Shin-Ichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

Diabetes research and clinical practice　169　108377-108377　2020年11月

DOI： 10.1016/j.diabres.2020.108377 　

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AIMS: To investigate the associations between glycosylated hemoglobin (HbA1c) levels at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan. METHODS: This was a prospective nationwide birth cohort study of 77,526 subjects with an HbA1c level of <6.5% (<48 mmol/mol) at less than 24 weeks of gestation. Associations of HbA1c level with adverse pregnancy outcomes were evaluated using multivariate analyses. RESULTS: The adjusted odds ratios per 1% (11 mmol/mol) increase in HbA1c level were 1.77 (95% confidence interval [CI]: 1.48-2.12) for hypertensive disorders of pregnancy; 1.78 (95% CI: 1.12-2.83) for placental abruption; 1.30 (95% CI: 1.12-1.50) for preterm birth; 2.11 (95% CI: 1.41-3.16) for very preterm birth; 1.49 (95% CI: 1.33-1.68) for low birth weight infants; 1.95 (95% CI: 1.42-2.70) for macrosomia; 1.23 (95% CI: 1.09-1.39) for small for gestational age; 1.15 (95% CI: 1.04-1.28) for large for gestational age; and 1.29 (95% CI: 1.20-1.39) for the composite adverse pregnancy outcome. CONCLUSIONS: The higher the HbA1c level, the higher the risk of adverse pregnancy outcomes in Japan. Further studies will be needed to determine prenatal management based on the HbA1c level in pregnant women with HbA1c <6.5% (<48 mmol/mol) at less than 24 weeks of gestation.
Maternal Baseline Characteristics and Perinatal Outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Junichi Sugawara, Mami Ishikuro, Taku Obara, Tomomi Onuma, Keiko Murakami, Masahiro Kikuya, Fumihiko Ueno, Aoi Noda, Satoshi Mizuno, Tomoko Kobayashi, Yohei Hamanaka, Kichiya Suzuki, Eiichi Kodama, Naho Tsuchiya, Akira Uruno, Yoichi Suzuki, Osamu Tanabe, Hideyasu Kiyomoto, Akito Tsuboi, Atsushi Shimizu, Seizo Koshiba, Naoko Minegishi, Soichi Ogishima, Gen Tamiya, Hirohito Metoki, Atsushi Hozawa, Nobuo Fuse, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama, Masayuki Yamamoto

Journal of epidemiology　32　(2)　69-79　2020年10月10日

DOI： 10.2188/jea.JE20200338 　

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BACKGROUND: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants. METHODS: Expectant mothers living in Miyagi prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group. RESULTS: A total of 23 406 pregnancies involving 23 730 fetuses resulted in 23 143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes and hypertensive disorders of pregnancy. CONCLUSIONS: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.
Social predictors of continued and indoor smoking among partners of non-smoking pregnant women: the TMM BirThree Cohort Study.

Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

Journal of epidemiology　31　(12)　635-641　2020年9月19日

DOI： 10.2188/jea.JE20200313 　

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BACKGROUND: Secondhand smoke (SHS) from partners is a major source of exposure for non-smoking women. However, epidemiological studies have rarely examined social factors associated with continued and indoor smoking among pregnant women's partners. METHODS: We analyzed data on 6091 partners of non-smoking pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Partners' age, education, income, workplace SHS exposure (almost never or sometimes, almost every day), and pregnant women's smoking history (never, quit before pregnancy awareness, quit after pregnancy awareness) were used as social factors. Multivariate logistic regression analyses were conducted to examine the associations of social factors with partners' continued smoking and indoor smoking. RESULTS: Among 2432 smoking partners, 2237 continued to smoke after pregnancy awareness. Workplace SHS exposure was associated with increased risk of partners' continued smoking: the odds ratio of workplace SHS exposure almost every day compared with almost never or sometimes was 2.08 (95% confidence interval, 1.52-2.83). Women's quitting smoking after-but not before-pregnancy awareness was associated with decreased risk of partners' continued smoking: the odds ratio of women's quitting after pregnancy awareness compared with never smoking was 0.57 (95% confidence interval, 0.40-0.80). About one-third of partners who continued to smoke did so indoors. Older age, lower education, workplace SHS exposure, and women's quitting smoking after pregnancy awareness were associated with increased risk of partners' indoor smoking. CONCLUSIONS: Workplace SHS exposure and pregnant women's smoking history were associated with continued smoking and indoor smoking among partners of non-smoking pregnant women.
Associations of Education and Income With Secondhand Smoke Exposure Among Non-Smoking Pregnant Women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

2020年9月3日
出版者・発行元： Research Square
DOI： 10.21203/rs.3.rs-64032/v1 　

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<title>Abstract</title> <bold>Background:</bold> Associations of education and income with secondhand smoke (SHS) exposure have been well documented in the general population. However, evidence among non-smoking pregnant women is limited, including in Japan. The purpose of the study was to examine the associations of education and income with SHS exposure among non-smoking pregnant women in Japan.<bold>Methods:</bold> We analyzed data from 17815 non-smoking pregnant women in Japan who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. SHS exposure was defined as indoor exposure to someone else’s cigarette smoke ≥1 day/week during pregnancy. Multiple logistic regression analyses were conducted to examine whether pregnant women’s educational attainment or equivalent household income was associated with SHS exposure, adjusting for age, work status, smoking history, partners’ education, and income/education. Stratified analyses by work status were also conducted.<bold>Results:</bold> The prevalence of SHS exposure during pregnancy was 34.0%; 29.4% among non-working women and 37.1% among working women. Lower educational attainment was associated with an increased risk of SHS exposure; the odds ratio of high school education or lower compared with university education or higher was 1.78 (95% confidence interval, 1.59–1.99). Lower equivalent household income was associated with an increased risk of SHS exposure; the odds ratio of the lowest compared with the highest level of income was 1.67 (95% confidence interval, 1.51–1.84). These associations did not differ between non-working women and working women.<bold>Conclusions:</bold> Pregnant women with lower education and/or lower household income had higher risks of SHS exposure in Japan. These findings imply that educational interventions and financial incentives are needed for pregnant women and their household smokers in helping to reduce SHS exposure among non-smoking pregnant women.
臨床試験論文の利用に関する薬剤師の実態調査

石井勇太, 中川直人, 小原拓, 大原宏司, 栗田幸代, 村井ユリ子

薬学雑誌　140　(9)　1195-1198　2020年9月
出版者・発行元： (公社)日本薬学会
ISSN：0031-6903

eISSN：1347-5231
【周産期メンタルヘルスの今】東北メディカル・メガバンク事業出生コホートを起点とした産後うつ病研究

菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 村上慶子, 小原拓, 長神風二, 栗山進一, 富田博秋

精神医学　62　(9)　1245-1251　2020年9月
出版者・発行元： (株)医学書院
ISSN：0488-1281

eISSN：1882-126X
How can we evaluate whether an association is truly inter-generational? 国際誌

Takuma Usuzaki, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Taku Obara, Shinichi Kuriyama

Journal of hypertension　38　(9)　1866-1868　2020年9月

DOI： 10.1097/HJH.0000000000002507 　
Survey on the Pharmacists Perceptions of Clinical Trial Literature Accessibility

Yuta Ishii, Naoto Nakagawa, Taku Obara, Hiroshi Ohara, Sachiyo Kurita, Yuriko Murai

YAKUGAKU ZASSHI　140　(9)　1195-1198　2020年9月1日
出版者・発行元： Pharmaceutical Society of Japan
DOI： 10.1248/yakushi.20-00009 　

ISSN：0031-6903

eISSN：1347-5231
Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. 国際誌査読有り

Maiko Wagata, Mami Ishikuro, Taku Obara, Masato Nagai, Satoshi Mizuno, Naoki Nakaya, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Hirohito Metoki, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama, Junichi Sugawara

Pregnancy hypertension　22　119-125　2020年8月5日

DOI： 10.1016/j.preghy.2020.08.001 　

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Low birth weight is known to be associated with hypertension, cardiovascular disease and hypertensive disorders of pregnancy (HDP); however, this association might vary by race/ethnicity. This study aimed to clarify the association between women's own birth weight and their subsequent risk for HDP in a Japanese population, in combination with pre-pregnancy body mass index (BMI). We conducted a cohort study as part of the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Miyagi, Japan. Our study's population included 4810 women. A multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (aOR) and the 95% confidence interval (CI) of the women's own birth weight for HDP, in the combination categories of birth weight and pre-pregnancy BMI. As a result, the group with a low birth weight of <2500 g had a significant association with HDP (the aOR, 1.50; 95% CI, 1.02-2.21). In the subtype analysis, the odds ratio for only preeclampsia was significantly increased in the low birth weight group (aOR, 3.37; 95% CI, 1.84-6.16). In the group with a low birth weight, the prevalence of HDP was higher in both the underweight and overweight groups. In conclusion, there was a significant association between low birth weight and subsequent HDP in Japanese women. Furthermore, a significant association with HDP was found for women born with a low birth weight who were underweight or overweight as adults. Maintaining a normal weight may be effective for preventing HDP even if a woman was born small.
Fruit and vegetable consumption before and during pregnancy and birth weight of new-borns in Japan: the Tohoku medical megabank project birth and three-generation cohort study. 国際誌査読有り

Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Junichi Sugawara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

Nutrition journal　19　(1)　80-80　2020年8月3日

DOI： 10.1186/s12937-020-00595-z 　

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BACKGROUND: Associations of fruit and vegetable consumption before and during pregnancy with birth weight of new-borns and the risk of low birth weight (LBW) remain unclear. METHODS: Between July 2013 and March 2017, we recruited 23,406 pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). Fruit and vegetable consumption before and during pregnancy was calculated using food frequency questionnaires. Information regarding birth weight was obtained from medical records, and LBW was defined as < 2500 g. We used a multivariable linear regression model and a multivariate logistic regression model to assess associations between fruit and vegetable consumption and birth weight/risk of LBW. RESULTS: In total, 17,610 women were included in the analysis. Mean birth weight was 3061.8 ± 354.1 g, and 5.4% of the new-borns had LBW. Compared to women in the lowest quartile of fruit consumption between pre- and early pregnancy, women in the highest quartile had heavier new-borns (β = 49.4; 95% CI: 34.1-64.7) and lower risk of LBW (OR: 0.79; 95% CI: 0.65-0.95). Women in the highest quartile of fruit consumption from early to mid-pregnancy also had heavier new-borns (β = 32.3; 95% CI: 17.1-47.6), and they tended to have lower risk of LBW (OR: 0.83; 95% CI: 0.69-1.01). Results of analysing the association between changes in fruit consumption from pre- to mid-pregnancy and birth outcomes revealed that women with continuous high fruit consumption from pre- to mid-pregnancy had heavier new-borns (β = 37.6; 95% CI: 25.0-50.3), but they did not have lower risk of LBW (OR: 0.90; 95% CI: 0.77-1.06). Associations involving vegetable consumption and birth weight/risk of LBW were not observed. CONCLUSIONS: Fruit consumption before and during pregnancy was positively associated with birth weight of new-borns and negatively associated with risk of LBW.
産後うつ病の予測と予防のための血漿サイトカインレベルの検証

兪志前, 小野千晶, 小原拓, 菊地沙耶, 小林奈津子, 菅原準一, 栗山進一, 山本雅之, 八重樫伸生, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020年8月
出版者・発行元：日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
産後うつ病の予測と予防のための血漿サイトカインレベルの検証

兪志前, 小野千晶, 小原拓, 菊地沙耶, 小林奈津子, 菅原準一, 栗山進一, 山本雅之, 八重樫伸生, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020年8月
出版者・発行元：日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
Social predictors of alcohol use and cessation during pregnancy among Japanese women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

2020年7月15日
出版者・発行元： Research Square
DOI： 10.21203/rs.3.rs-40323/v1 　

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<title>Abstract</title> <bold>Background:</bold> Most studies on social predictors of alcohol use have been conducted at one time point during pregnancy or using postpartum retrospective reports. Furthermore, the studies were mainly conducted in Western countries. We aimed to prospectively examine social predictors of alcohol use and cessation during pregnancy in Japan.<bold>Methods:</bold> This prospective study was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Pregnant women were recruited at approximately 50 obstetric clinics and hospitals in Miyagi Prefecture in Japan. We analyzed 11592 pregnant women who completed the questionnaires administered in early pregnancy and middle pregnancy. Women were dichotomized as current drinkers or non-drinkers in both early and middle pregnancy. Age, education, income, work status, and psychological distress were used as social predictors. Multivariate logistic regression analyses were conducted to examine associations between these predictors and alcohol use in early and middle pregnancy. Associations with alcohol cessation between early pregnancy and middle pregnancy were also examined.<bold>Results:</bold> Prevalence of alcohol use in early and middle pregnancy was 20.9% and 6.4%, respectively. Higher education was associated with alcohol use in early pregnancy and alcohol cessation during pregnancy; the odds ratios (ORs) of ≥university education compared with ≤high school education were 1.47 (95% confidence interval [CI], 1.30–1.66) and 1.31 (95% CI, 1.00–1.71), respectively. Work status was associated with alcohol use in both periods and alcohol cessation during pregnancy; for alcohol cessation, the OR of working in early pregnancy only compared with not working in both periods was 1.72 (95% CI, 1.03–2.88).<bold>Conclusions:</bold> Women with higher education were more likely to consume alcohol in early pregnancy and to cease between early pregnancy and middle pregnancy. Working women were more likely to consume alcohol throughout pregnancy in Japan.
Characteristics of Adverse Events Following Immunization Reporting in Children: The Japanese Adverse Drug Event Report Database. 国際誌査読有り

Aoi Noda, Takamasa Sakai, Masami Tsuchiya, Gen Oyanagi, Taku Obara, Nariyasu Mano

Vaccines　8　(3)　2020年7月3日

DOI： 10.3390/vaccines8030357 　

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The present study aimed to describe the trends and characteristics of adverse events following immunization (AEFI) reporting for children in the Japanese Adverse Drug Event Report database (JADER). We used 6280 AEFI reports for children aged <19 years among 504,407 ADR reports included in the JADER from 2004 to 2017. The number of AEFI reports gradually increased among children aged <10 years and was the highest in 2011 among children aged 10-19 years. The number of suspected vaccines per AEFI report increased after 2011 among children aged <10 years. The percentage of "death" and "did not recover" as AEFI outcomes reported were 4.3% and 3.7% among children aged <10 years and 0.2% and 21.1% among children aged 10-19 years, respectively. The most frequently reported vaccine-reaction pair was Haemophilus influenzae type b conjugate vaccine and pyrexia among children aged <10 years and recombinant adsorbed bivalent human papillomavirus-like particle vaccine and a loss of consciousness among children aged 10-19 years. It is necessary to consider the Weber effects to understand the trend and characteristics of AEFI reporting because pharmacovigilance activity regarding vaccination is not sufficient in Japan.
Folic acid prescribed to prenatal and postpartum women who are also prescribed antiepileptic drugs in Japan: Data from a health administrative database. 国際誌査読有り

Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Birth defects research　112　(16)　1224-1233　2020年7月2日

DOI： 10.1002/bdr2.1748 　

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BACKGROUND: The aim of this study was to evaluate the prevalence of folic acid (FA) prescription to prenatal and postpartum women who have also been prescribed antiepileptic drugs (AED) in Japan. METHODS: The data set used in this study included women covered by health insurance between 2005 and 2016. The prevalence of FA prescriptions between 180 days before pregnancy and 180 days postpartum was determined from a large administrative database, with the FA prescription classified according to dose and timing. RESULTS: For 33,941 women meeting our eligibility criteria, the mean maternal age at delivery was 32.3 years. At least one AED was prescribed to 225 of 33,941 women between 180 days before pregnancy and 180 days postpartum. FA was prescribed to 32 of 225 women (14.2%) during the same period. FA was prescribed to 8.8% of women with AED within 90 days before pregnancy and to 19.8% during the first trimester. FA was prescribed to 10.9% during the first 30 days after conception, all of whom were prescribed FA before the pregnancy. The maximum FA dose prescribed within 90 days before pregnancy was 5 mg/day for 5 of 12 women (41.7%) and >5 mg/day for 4 of 12 women (33.3%). The maximum FA dose prescribed during the first trimester was 5 mg/day for 14 of 22 women (63.6%) and >5 mg/day for 8 of 22 women (36.4%). CONCLUSIONS: The concurrent prescription of FA with AEDs in Japan was an uncommon therapeutic approach both before and during pregnancy.
【妊娠・出産と精神科臨床アップデート】授乳期の精神科薬物療法

菊地紗耶, 小林奈津子, 小原拓, 本多奈美, 富田博秋

臨床精神医学　49　(7)　907-915　2020年7月
出版者・発行元： (株)アークメディア
ISSN：0300-032X
Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study. 国際誌査読有り

Noriyuki Iwama, Mari S Oba, Michihiro Satoh, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Satomi Sasaki, Masatoshi Saito, Yoshitaka Murakami, Shin-Ichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　43　(6)　550-559　2020年6月

DOI： 10.1038/s41440-020-0416-2 　

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This study investigated the association between maternal home blood pressure (HBP) trajectory during pregnancy and infant birth weight. A total of 755 pregnant women were included in this prospective cohort study. A group-based trajectory model identified six trajectory groups for home systolic blood pressure (SBP), diastolic BP (DBP), and mean arterial pressure (MAP). Next, the association of HBP trajectory groups with infant birth weight was evaluated using a general linear model considering potential confounding factors. For home SBP and MAP, the trajectory groups with a low-steep J-curve, moderate J-curve, little high J-curve, and high J-curve were significantly associated with lower infant birth weight than the low-J-curve group. Among the trajectory groups for home DBP, the moderate-steep J-curve, little high J-curve, and high J-curve were significantly associated with lower infant birth weight than the group with low-J-curve. The effect sizes of the trajectory groups varied in infant birth weight from -0.21 standard deviations (SDs) (95% confidence interval (CI): -0.42 to -0.01 SD) to -1.13 SD (95% CI: -1.54 to -0.72 SD). In the analyses of infant birth weight in grams, effect sizes that were significantly associated with infant birth weight varied from -84 g (95% CI: -167 to -1 g) to -567 g (95% CI: -732 to -402 g). Trajectory groups with a moderate-reverse J-curve for home SBP, DBP, and MAP were not significantly associated with infant birth weight. Maternal HBP trajectory during pregnancy was an indicator of infant birth weight. Further studies evaluating the associations between HBP during pregnancy and other perinatal outcomes are needed.
Characteristics of pediatric adverse drug reaction reports in the Japanese Adverse Drug Event Report Database. 国際誌査読有り

Aoi Noda, Takamasa Sakai, Taku Obara, Makoto Miyazaki, Masami Tsuchiya, Gen Oyanagi, Yuriko Murai, Nariyasu Mano

BMC pharmacology & toxicology　21　(1)　36-36　2020年5月24日

DOI： 10.1186/s40360-020-00412-7 　

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BACKGROUND: There are no reports on investigations of the characteristics of adverse drug reaction (ADR) reports for pediatric patients in the Japanese Adverse Drug Event Report database (JADER) and the utility of database for drug safety surveillance in these patients. METHOD: We aimed to evaluate ADR reports for pediatric patients in the JADER. We used spontaneous ADR reports included in the JADER since April 1, 2004, to December 31, 2017, which was downloaded in April 2018. In a total of 504,407 ADR reports, the number of spontaneous reports was 386,400 (76.6%), in which 37,534 (7.4%) were unknown age reports. After extraction of 27,800 ADR reports for children aged < 10 and 10-19 years, we excepted for ADR reports associated with a vaccine (n = 6355) and no-suspected drug reports (n = 86). A total of 21,359 (4.2%) reports were finally included in this analysis. RESULTS: More than half of the ADR reports were for children aged < 10 years. Approximately 30% of ADR reports had multiple suspected drugs, which did not differ by age. The percentages of fatal outcomes of ADRs among patients aged < 10 and 10-19 years were 4.7 and 3.9%, respectively. The most frequently reported drug, reaction, and drug-reaction pair were oseltamivir, abnormal behavior, and oseltamivir and abnormal behavior, respectively. CONCLUSION: We clarified the characteristics of ADR reports for Japanese children by using the JADER. ADR report databases, especially those for pediatric patients, are valuable pharmacovigilance tools in Japan and other countries. Therefore, a proper understanding of the characteristics of the ADR reports in the JADER is important. Additionally, potential signals for ADRs in pediatric patients should be monitored continuously and carefully.
Quantitative analysis of paracetamol, metacetamol, and orthocetamol in equine urine from racehorses in Japan using liquid chromatography-electrospray ionisation-tandem mass spectrometry. 国際誌査読有り

Hideaki Ishii, Taku Obara, Kanichi Kusano, Isao Kijima-Suda

Drug testing and analysis　2020年5月20日

DOI： 10.1002/dta.2860 　

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Paracetamol is commonly used as an over-the-counter analgesic and antipyretic medication for humans, but not sold as a legitimate therapeutic medication for horses in Japan. However, paracetamol is commonly found in horses together with its two isomers, metacetamol and orthocetamol. We previously reported that paracetamol and orthocetamol were both present in selected feed consumed by Japanese racehorses. For the purpose of doping control of paracetamol in local Japanese horses, we proposed establishing residue limits (Japanese residue limits, JRLs) to minimise the risk of reporting paracetamol from environmental contributions and differentiate its presence from active administration. Recently, we proposed a preliminary JRL for paracetamol in equine plasma based on a population study in more than 300 Japanese racehorses. In this paper, we will present our studies on the urinary concentrations of paracetamol, metacetamol, and orthocetamol in postrace samples collected from 403 Japanese racehorses over a one-year period, detected using liquid chromatography-electrospray ionisation-tandem mass spectrometry. Our results revealed that the hydrolysed urinary concentrations of paracetamol, metacetamol, and orthocetamol ranged from 15.7 to 2,360 ng/mL (median 363 ng/mL), 8.07 to 382 ng/mL (84.5 ng/mL), and 919 to 74,418 ng/mL (13,475 ng/mL), respectively. Based on our statistical model, the preliminary JRL of hydrolysed paracetamol in equine urine was determined to be 7,400 ng/mL at a risk factor of 1 in 10,000. Further investigations will be required to demonstrate the applicability and validity of our preliminary plasma and urine JRLs to local Japanese racehorses.
Changes in community pharmacists' knowledge, attitudes, and practice regarding the management of hypertension before and after educational interventions. 国際誌査読有り

Aoi Noda, Taku Obara, Kazuki Takada, Yukinaga Kishikawa, Shinya Abe, Shoko Yoshimachi, Nariyasu Mano, Yutaka Imai, Teruaki Goto

Clinical and experimental hypertension (New York, N.Y. : 1993)　42　(4)　322-327　2020年5月18日

DOI： 10.1080/10641963.2019.1652634 　

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Objective: To clarify changes in community pharmacists' knowledge, attitudes, and practice regarding the management of hypertension before and after attending educational interventions based on their self-report on a questionnaire survey.Method: We conducted questionnaire surveys regarding the management of hypertension with a sample of community pharmacists before and after educational interventions.Results: The proportions of pharmacists who knew the 2014 Japanese Society of Hypertension Guidelines, guidelines for home blood pressure measurement, reference values for hypertension based on clinic-measured blood pressure, and reference values for hypertension based on home-measured blood pressure after the educational interventions (59.3%, 41.4%, 75.1%, and 70.8% respectively) were significantly higher relative to those recorded before interventions (31.6%, 13.7%, 47.7%, and 25.4% respectively).Conclusions: These findings suggest that in-house training might increase the knowledge of community pharmacists regarding hypertension management.
Examining the trimester-specific effects of low gestational weight gain on birthweight: the BOSHI study. 国際誌査読有り

Mari S Oba, Yoshitaka Murakami, Michihiro Satoh, Takahisa Murakami, Mami Ishikuro, Taku Obara, Kazuhiko Hoshi, Yutaka Imai, Takayoshi Ohkubo, Hiroto Metoki

Journal of developmental origins of health and disease　12　(2)　1-6　2020年4月22日

DOI： 10.1017/S2040174420000240 　

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Low gestational weight gain (GWG) is a known risk factor of low birthweight. Although studies have previously examined the associations between GWG and birthweight, the period-specific effects of low GWG in each trimester remain unclear. This study aimed to quantify the trimester-specific direct effects of low GWG in Japanese women on birthweight. Using perinatal data from a cohort study, we analyzed pregnant women delivered at an obstetrics/gynecology hospital between October 2006 and May 2010. We focused on women with a pre-pregnancy body mass index (BMI) below 25 kg/m2. The exposure was low GWG. The gestation period was subdivided into trimesters, and the direct effects of low trimester-specific GWG on birthweight were estimated using marginal structural models. These models were guided by a direct acyclic graph that incorporated potential confounders, including pre-pregnancy BMI, age, smoking during pregnancy, height, and parity. We analyzed 563 women and their families. The mean cumulative GWG by the end of the first, second, and third trimesters was 0.9, 6.2, and 10.7 kg, respectively. Approximately 14.0% of the women gained total weight below the range recommended by Japanese Ministry of Health, Labour and Welfare. The direct effects of low GWG on birthweight were 65.9 g (95% confidence interval: 11.4, 120.5), -195.4 g (-263.4, -127.4), and -188.8 g (-292.0, -85.5) for the first, second, and third trimesters, respectively. Insufficient weight gain in the second and third trimesters had a negative impact on birthweight after adjusting for pre-pregnancy BMI and other covariates.
Publisher Correction: Inadequate Folic Acid Intake Among Women Taking Antiepileptic Drugs During Pregnancy in Japan: A Cross-Sectional Study. 国際誌査読有り

Yasuko Ikeda-Sakai, Yoshiyuki Saito, Taku Obara, Mikako Goto, Tami Sengoku, Yoshimitsu Takahashi, Hiromi Hamada, Takeo Nakayama, Atsuko Murashima

Scientific reports　10　(1)　6414-6414　2020年4月14日

DOI： 10.1038/s41598-020-63105-5 　

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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

寳澤篤, 土屋菜歩, 平田匠, 小暮真奈, 成田暁, 中村智洋, 中谷直樹, 小原拓, 栗山進一, 菅原準一, 呉繁夫

宮城県公衆衛生学会会誌　(52)　20-20　2020年4月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
非喫煙妊婦における教育歴と受動喫煙の関連東北メディカル・メガバンク計画三世代コホート調査

村上慶子, 小原拓, 石黒真美, 上野史彦, 野田あおい, 大柳元, 菊谷昌浩, 目時弘仁, 栗山進一

宮城県公衆衛生学会会誌　(52)　22-22　2020年4月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
妊娠初期の家庭血圧レベルと短期及び長期の母児予後との関連

目時弘仁, 佐藤倫広, 村上任尚, 岩間憲之, 佐々木里美, 高畠恭介, 石黒真美, 小原拓, 菊谷昌浩, 大久保孝義, 八重樫伸生, 星和彦, 今井潤

宮城県公衆衛生学会会誌　(52)　13-13　2020年4月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

寳澤篤, 土屋菜歩, 平田匠, 小暮真奈, 成田暁, 中村智洋, 中谷直樹, 小原拓, 栗山進一, 菅原準一, 呉繁夫

宮城県公衆衛生学会会誌　(52)　20-20　2020年4月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
妊娠初期の家庭血圧レベルと短期及び長期の母児予後との関連

目時弘仁, 佐藤倫広, 村上任尚, 岩間憲之, 佐々木里美, 高畠恭介, 石黒真美, 小原拓, 菊谷昌浩, 大久保孝義, 八重樫伸生, 星和彦, 今井潤

宮城県公衆衛生学会会誌　(52)　13-13　2020年4月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
The quality assessment of the Japanese Adverse Drug Event Report database using vigiGrade. 国際誌査読有り

Masami Tsuchiya, Taku Obara, Makoto Miyazaki, Aoi Noda, Chizuko Takamura, Nariyasu Mano

International journal of clinical pharmacy　42　(2)　728-736　2020年4月

DOI： 10.1007/s11096-020-00969-7 　

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Background The quality of adverse drug reaction reports can have a strong influence on the causality assessment or the detection of safety signals. Various methods have been used to evaluate the quality of adverse drug reaction reports. Objective We used the vigiGrade completeness score to evaluate the quality of the Japanese adverse drug event report database (JADER). Methods Among all reports in the JADER (cases received by regulatory authorities from April 2004 to November 2018), 427,797 cases that did not meet the exclusion criteria were analyzed using vigiGrade. An report was considered a 'well-documented' report if the completeness score > 0.8. For each dimension, the proportion of incomplete information was calculated. Main outcome measure Proportion of 'well-documented' reports. Results A total of 211,774 (49.5%) cases were classified as 'well-documented' reports. When classified by sender, 6240 out of 8257 cases (75.6%) from medical institutions were 'well-documented', while 205,534 out of 419,540 cases (49.0%) from pharmaceutical companies were categorized as such. 'Time-to-onset' could not be calculated in 173,027 (41.2%) cases from the pharmaceutical companies and in 1228 (14.9%) cases from medical institutions. Conclusion In the JADER, the proportion of 'well-documented' adverse drug reaction reports from medical institutions was higher than that from pharmaceutical companies, and reports from medical institutions could help to clarify generated safety signals. We also found that more than 40% of the reports from pharmaceutical companies did not include information that is considered essential for the evaluation of any causal relationship between suspected drugs and adverse drug reactions, which could pose challenges to the detection of safety signals.
Investigation of plasma concentrations of paracetamol, metacetamol, and orthocetamol in Japanese racehorses using liquid chromatography-electrospray ionisation-tandem mass spectrometry. 国際誌査読有り

Hideaki Ishii, Taku Obara, Isao Kijima-Suda

Drug testing and analysis　2020年3月18日

DOI： 10.1002/dta.2792 　

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Paracetamol is used widely as an over-the-counter analgesic and antipyretic medication for humans, but not for Japanese racehorses. Paracetamol can be an environmental substance, and is found together with its two isomers, metacetamol and orthocetamol, in equine urine. However, the sources and routes of paracetamol exposure remain unclear. To control the misuse of paracetamol, it is appropriate to establish residue limits for paracetamol to differentiate the administration of paracetamol from its environmental levels. In this study, we developed and validated a quantitative method for paracetamol, metacetamol, and orthocetamol in equine plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry and applied it to postrace samples from 320 Japanese racehorses for approximately 1 year. In addition, we conducted feed analysis and related pharmacokinetics simulations to evaluate the contributions from exposure via feed. The hydrolyzed plasma concentrations of paracetamol, metacetamol, and orthocetamol ranged from 0.787 to 39.8 ng/mL (median 5.87 ng/mL), 0 to 2.13 ng/mL (0.347 ng/mL), and 1.98 to 82.8 ng/mL (16.6 ng/mL), respectively. Such low concentrations of paracetamol were deemed irrelevant to therapeutic effect. Based on statistical analysis, the preliminary Japanese residue limits of unhydrolyzed and hydrolyzed paracetamol were determined to be 70.5 ng/mL and 112 ng/mL, respectively, in plasma, at a risk factor of 1 in 10,000. Furthermore, we detected paracetamol and orthocetamol in feed samples. A pharmacokinetics simulation showed that the presence of orthocetamol is most probably related to daily feed rations. As for paracetamol, feed can be one of the sources and other possible sources require further investigation.
Evaluating folic acid supplementation among Japanese pregnant women with dietary intake of folic acid lower than 480 µg per day: results from TMM BirThree Cohort Study. 国際誌査読有り

Daisuke Kikuchi, Taku Obara, Takuma Usuzaki, Yudai Yonezawa, Takahiro Yamashita, Gen Oyanagi, Aoi Noda, Fumihiko Ueno, Keiko Murakami, Hiroko Matsubara, Mami Ishikuro, Hirohito Metoki, Masahiro Kikuya, Shinichi Kuriyama

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　35　(5)　1-6　2020年3月13日

DOI： 10.1080/14767058.2020.1739020 　

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Objective: In Japan, supplementation with 400 µg of folic acid per day is recommended for women who are planning to get pregnant to decrease the risk of their babies getting neural tube defects (NTD). However, the proportion of women who have taken folic acid supplements before conception is low among Japanese pregnant women. In addition, the dietary intake of folic acid has not yet reached the government recommended dietary intake levels (480 µg per day). This study aimed to clarify the prevalence and determinants of adequate folic acid supplements among Japanese pregnant women with dietary folic acid intake lower than 480 µg per day.Methods: This cross-sectional study was a part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. We collected information on folic acid supplements before conception, sociological/lifestyle characteristics, and food consumption. The primary outcome was the use of folic acid supplements (adequate or inadequate, based on the timing of initiation of folic acid supplements). Multiple logistic regression analysis was used to examine the association between sociological/lifestyle characteristics and the adequate intake of folic acid supplements.Results: Among the 11,562 pregnant women who took lower than 480 µg per day of folic acid from food, the prevalence of adequate users was 18.0%. Pregnant women who reported adequate use of folic acid supplements were more likely to be older and educated; and reported higher household income, and history of fertility treatment. Conversely, they were less likely to be ever or current smokers and multipara.Conclusion: This study found that the prevalence of folic acid supplements use for the prevention of NTD among Japanese pregnant women was still low.
Bootstrap法およびPermutation法の応用による三世代家族の身長、体重、BMIの世代間関連の評価三世代コホート調査

臼崎琢磨, 石黒真美, 村上慶子, 野田あおい, 上野史彦, 目時弘仁, 菊谷昌浩, 小原拓, 栗山進一

日本衛生学雑誌　75　(Suppl.)　S158-S158　2020年3月
出版者・発行元： (一社)日本衛生学会
ISSN：0021-5082

eISSN：1882-6482
家系情報付き出生三世代コホートの構築に基づく成果の還元と試料・情報の分譲

小原拓, 村上慶子, 石黒真美, 上野史彦, 野田あおい, 菊谷昌浩, 目時弘仁, 栗山進一

日本衛生学雑誌　75　(Suppl.)　S158-S158　2020年3月
出版者・発行元： (一社)日本衛生学会
ISSN：0021-5082

eISSN：1882-6482
薬局勤務薬剤師における副作用等報告制度の認識と実践

原梓, 山口浩, 小原拓, 神藤愛実, 沢諒, 阿部真也, 吉町昌子, 後藤輝明, 宮崎生子, 眞野成康

日本薬学会年会要旨集　140年会　27P-pm032　2020年3月
出版者・発行元： (公社)日本薬学会
ISSN：0918-9823
Antidepressant prescriptions for prenatal and postpartum women in Japan: A health administrative database study. 国際誌査読有り

Tomofumi Ishikawa, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Keiko Miyakoda, Hidekazu Nishigori, Hiroaki Tomita, Manabu Akazawa, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Journal of affective disorders　264　295-303　2020年3月1日

DOI： 10.1016/j.jad.2020.01.016 　

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BACKGROUND: The prevalence and pattern of perinatal antidepressant prescriptions in Japan are unknown. METHODS: The prevalence of antidepressant prescriptions between 180 days before pregnancy onset and 180 days postpartum was evaluated using a large administrative database. The dates of pregnancy onset and delivery were estimated using developed algorithms. RESULTS: Of 33,941 women, at least one antidepressant was prescribed to 451 (133/10,000 deliveries) between 180 days before pregnancy and 180 days postpartum and to 241 (71/10,000 deliveries) during pregnancy. The prevalence of antidepressant prescriptions decreased during the first and second trimesters and increased in the postpartum period. Of 339 women with antidepressant prescriptions before pregnancy, 151 (44.5%) discontinued it during pregnancy. Selective serotonin-reuptake inhibitors were the most frequently prescribed class of antidepressants in the time period studied (356 women, 105/10,000 deliveries), followed by tricyclic/non-tricyclic antidepressants (101 women, 30/10,000 deliveries). Of the 57 women who had at least one record of paroxetine prescription in the first trimester, 13 (22.8%) were prescribed >25 mg/day. Fifty-seven women (17/10,000 deliveries) were concurrently prescribed two or more classes of antidepressants between 180 days before pregnancy and 180 days postpartum. LIMITATIONS: It may not always have been the case that the prescribed antidepressants were used. Women whose pregnancy ended in an abortion or stillbirth were not included. CONCLUSIONS: Various antidepressants were prescribed to prenatal and postpartum women in Japan. Approximately half of pregnant women discontinued treatment with antidepressants after becoming pregnant. Women of childbearing age should select an appropriate antidepressant considering the risk/benefit profile.
Quality evaluation of the Japanese Adverse Drug Event Report database (JADER). 国際誌査読有り

Masami Tsuchiya, Taku Obara, Takamasa Sakai, Kaori Nomura, Chizuko Takamura, Nariyasu Mano

Pharmacoepidemiology and drug safety　29　(2)　173-181　2020年2月

DOI： 10.1002/pds.4944 　

ISSN：1053-8569

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INTRODUCTION: The spontaneous adverse drug reaction (ADR) reporting system plays an important role in pharmacovigilance by providing information from clinical settings in the postmarketing environment. The Japanese Adverse Drug Event Report (JADER) database contains a portion of Japanese ADR reports, and no previous study has described the quality or characteristics of ADR reports in the JADER. OBJECTIVE: The aim of this study was to identify the characteristics of the JADER database and to evaluate the quality of ADR reports contained in the JADER using the documentation-grading scheme developed by the World Health Organization. METHODS: Of 478 508 ADR reports in the JADER, the analysis set consisted of 395 091 reports meeting inclusion criteria. An analysis was carried out to evaluate the quality of the reports according to the type of report, the type of sender, and the qualification of the reporter. Annual changes in the number of reports from medical institutions submitted by pharmacists were compared with changes in the number submitted by physicians. RESULTS: The distribution of documentation grade differed according to the type of report, the type of sender, and the qualification of the reporter. Regarding "medical institution reports", the quality of reports was similar among qualification types, while the quality of reports submitted by physicians was higher for "company reports" and "study reports" (P < .0001, respectively). CONCLUSION: Our study showed that the quality of the ADR reports in the JADER differed among the type of report, the sender of the report, and the qualification of the reporter.
Update on the prevalence and determinants of folic acid use in Japan evaluated with 91,538 pregnant women: the Japan Environment and Children's Study. 国際誌査読有り

Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(3)　427-436　2020年2月

DOI： 10.1080/14767058.2018.1494712 　

ISSN：1476-7058

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Objective: To provide the latest and most promising evidence on the prevalence and determinants for folic acid supplementation in pregnant women in Japan, including differences in prevalence between interview years and determinants across regions.Materials and methods: The study participants were enrolled from 15 regional centers across Japan between January 2011 and March 2014. Information on the use of folic acid supplementation before and during pregnancy and the characteristics of the participants were collected using questionnaires, medical chart reviews, and interviews by research coordinators.Results: Data for 91,538 women who provided sufficient data on folic acid supplementation were analyzed. The prevalence of adequate users was 8.0%, which, although low, tended to improve over the 4-year recruitment period. Various kinds of sociodemographic factors, lifestyle habits, and obstetrical and medication use history were significant and independent determinants for folic acid use. Associations between adequate preconception folic acid use and its major determinants tended to be similar across regions.Conclusions: Although the prevalence of adequate folic acid use was low, it increased from 2011 to 2014. Reproductive-aged women who have determinants for inadequate folic acid use should be informed about the need for preconception folic acid supplementation to help prevent neural tube defects.
Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. 国際誌査読有り

Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

International journal of epidemiology　49　(1)　18-19　2020年2月1日

DOI： 10.1093/ije/dyz169 　

ISSN：0300-5771
Study profile of The Tohoku Medical Megabank Community-Based Cohort Study. 査読有り

Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

Journal of epidemiology　31　(1)　65-76　2020年1月11日

DOI： 10.2188/jea.JE20190271 　

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BackgroundWe established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environmental interactions on the incidence of major diseases such as cancer and cardiovascular diseases.MethodsWe asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria was aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), for example, carotid echography, calcaneal ultrasound bone mineral density, and so on. All participants agreed to measure genome information and to distribute their information widely.ResultsAs a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants with Type 1 survey were more likely to have psychological distress than those of Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents regardless of sex.ConclusionThis cohort comprised large sample size and it contains information on disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.
Drug Prescriptions for Children With ADHD in Japan: A Study Based on Health Insurance Claims Data Between 2005 and 2015. 国際誌査読有り

Makiko Yoshida, Taku Obara, Saya Kikuchi, Michihiro Satoh, Yoshihiko Morikawa, Nobuhiro Ooba, Hiroaki Yamaguchi, Nariyasu Mano

Journal of attention disorders　24　(2)　175-191　2020年1月

DOI： 10.1177/1087054719843179 　

ISSN：1087-0547

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Objective: The aim of this study is to investigate the trend of prescription drugs for children with ADHD in Japan. Method: Using health insurance claims data of 3,672,951 people between January 2005 and December 2015, we investigated the trend of prescription drugs for 7,856 children with ADHD. Results: After approval in 2007, the proportion of prescriptions for methylphenidate-osmotic-controlled release oral delivery system tablets was 31.4% in 2009 (adjusted odds ratio [AOR] = 2.72; 95% confidence interval [CI] = [2.12, 3.51]) and reached a plateau approximately after 2009 (AOR = 0.96; 95% CI = [0.94, 0.98]). The proportion of prescriptions for atomoxetine increased from 6.1% in 2008 to 21.8% in 2014 (AOR = 1.12; 95% CI = [1.13, 1.18]). The proportion of prescriptions for aripiprazole and ramelteon increased (all trend p < .001). Conclusion: Prescriptions of drugs for children with ADHD have changed. We need to monitor the safety of ADHD medications among children with ADHD.
The present situation of home blood pressure measurement among outpatients in Japan. 国際誌査読有り

Aoi Noda, Taku Obara, Shinya Abe, Shoko Yoshimachi, Michihiro Satoh, Mami Ishikuro, Azusa Hara, Hirohito Metoki, Nariyasu Mano, Takayoshi Ohkubo, Teruaki Goto, Yutaka Imai

Clinical and experimental hypertension (New York, N.Y. : 1993)　42　(1)　67-74　2020年

DOI： 10.1080/10641963.2019.1571601 　

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Objective: To clarify the present situation of home blood pressure (HBP) measurement among Japanese patients.Methods: A nationwide questionnaire survey regarding HBP measurement was conducted on patients aged 20 years or older who had visited 20 community pharmacies to have their prescriptions filled.Results: In total, 76.7% of 1,103 hypertensives and 40.9% of 1,106 normotensives had their own devices for HBP measurement. Compared with normotensives, a higher proportion of hypertensives recognized the guideline-based reference values for HBP and clinic BP. Compared with hypertensives who did not have a physician's recommendation, those who did more often had their own devices, recognized the guideline-based reference values for HBP, and measured HBP every day (70.4%, 1.5%, and 31.6% vs. 91.1%, 6.9%, and 65.4%, respectively). Among 793 hypertensives who measured HBP, a higher proportion of those with a physician's recommendation measured HBP according to optimal guideline-based procedures compared with those without. Among 560 hypertensives who recorded HBP readings, a higher proportion of those with a physician's recommendation (74.6%) showed all HBP readings to their physicians compared with those without (35.3%).Conclusions: Our findings suggest that physicians should recommend measuring HBP in accordance with the Japanese Society of Hypertension guidelines more aggressively, and provide more detailed explanations to patients regarding how to measure HBP.
Effectiveness of seasonal inactivated influenza vaccination in Japanese schoolchildren: an epidemiologic study at the community level. 国際誌査読有り

Yasutaka Kuniyoshi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Masato Nagai, Keiko Murakami, Aoi Noda, Masahiro Kikuya, Shigeo Kure, Shinichi Kuriyama

Human vaccines & immunotherapeutics　16　(2)　295-300　2020年

DOI： 10.1080/21645515.2019.1655833 　

ISSN：2164-5515

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Influenza vaccination is the most effective method for preventing influenza virus infection. The incidence of influenza is higher in schoolchildren than other age groups. This study evaluated the effectiveness of seasonal inactivated influenza vaccination (IIV) in a community population of schoolchildren during two seasons. This study was a cross-sectional survey of public schoolchildren based on data collected in the 2012/2013 and 2014/2015 seasons. The questionnaire was distributed to all public schoolchildren of target grade in a survey area, and 7945 respondents were included in the analysis. The vaccination status and influenza onset were defined based on the self-reported questionnaire by parents or guardians. Generalized linear mixed models were used to adjust clustering within schools and individual covariates and calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between vaccination status and influenza onset. The influenza incidence was higher in the 2015 than the 2013 survey (25% versus 17%), although the vaccination rates were comparable between the two seasons. Receiving one- or two-dose vaccination was more protective against influenza than non-vaccination in both the 2013 (OR, 0.77; 95%CI, 0.65-0.92) and 2015 (OR, 0.88; 95%CI, 0.75-1.02) surveys. Full vaccination was also more protective in both the 2013 (OR, 0.75; 95%CI, 0.62-0.89) and 2015 (OR, 0.86; 95%CI, 0.74-1.00) surveys. Seasonal IIV was protective against influenza for Japanese schoolchildren in a community-based real-world setting. The difference in clinical effectiveness of IIV between the two seasons was likely due to the antigenic mismatch between the circulating and vaccine strains.
大規模健診時血圧データに基づく加齢に伴う血圧推移に関する縦断解析査読有り

佐藤倫広, 村上任尚, 小原拓, 辰巳友佳子, 高畠恭介, 原梓, 浅山敬, 今井潤, 菊谷昌浩, 大久保孝義, 目時弘仁

日本循環器病予防学会誌　54　(3)　163-170　2019年12月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. 国際誌査読有り

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

Disaster medicine and public health preparedness　13　(5-6)　905-911　2019年12月

DOI： 10.1017/dmp.2019.8 　

ISSN：1935-7893

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OBJECTIVE: We aimed to investigate the association between types of housing and allergic symptoms at 3-4 years following the Great East Japan Earthquake. METHODS: Our study was based on the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey of public school children in Miyagi Prefecture, Japan. Of the 46 648 invited schoolchildren in the 2nd to 8th grades, 9884 were included. Presence of eczema, wheezing, and mental health symptoms was defined with questionnaires. To calculate odds ratios (ORs) and 95% CIs for the associations between types of housing and eczema or respiratory symptoms, we fitted generalized linear mixed models, included a random effect for municipality of residence, and adjusted for sex, school grade, survey year, and mental health symptoms. RESULTS: Prefabricated temporary housing was significantly associated with eczema symptoms (OR, 1.46; 95% CI, 1.06-2.02). Even after adjusting for the presence of mental health symptoms, our analysis produced similar results (OR, 1.42; 95% CI, 1.03-1.96). Conversely, it was not significantly associated with respiratory symptoms (OR, 0.97; 95% CI, 0.61-1.54). CONCLUSIONS: Children living in prefabricated temporary housing had a higher prevalence of eczema symptoms; however, prevalence of respiratory symptoms was not significantly higher.
Maternal dietary patterns during early pregnancy and birth weight in Japan

Taku Obara, Hiroyuki Suganuma, Mami Ishikuro, Takuma Usuzaki, Takahiro Yamashita, Fumihiko Ueno, Yudai Yonezawa, Shinichi Kuriyama, Aoi Noda, Keiko Murakami

European Journal of Public Health　29　2019年11月1日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/eurpub/ckz187.128 　

ISSN：1101-1262

eISSN：1464-360X

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<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>The average birth weight in Japan has decreased by 200 g in the last 40 years. Only three studies were reported for the association between maternal dietary patterns and birth weight in East Asia, whose results were inconsistent. We examined what maternal dietary patterns were associated with the birth weight in Japan.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Totally 22,493 pregnant women were recruited between July 2013 and September 2016 into the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. We included 17,287 women who had a full-term single healthy baby into the analysis. Consumption of food and beverage items was evaluated based on food frequency questionnaire at the first-trimester. Dietary patterns were analyzed using a machine learning method of k-means clustering algorithm. Birth weight was obtained from the medical record. The association between dietary patterns and birth weight was analyzed using multiple liner regression model adjusted for potential confounders with multiple imputation method for missing values.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Dietary patterns were classified into seven groups by cluster analysis: “high in rice (reference) (n = 8046)”, “middle in vegetables, beans, mushrooms, seaweeds and miso-soup (n = 4842)”, “high in fruits (n = 1176)”, “high in bread, dairy and alcohol (n = 1091)”, “high in meat and fish (n = 1049)”, “high in coffee, black tea, soft drinks and confections (high in coffee) (n = 585)”, and “high in vegetables, beans, mushrooms, seaweeds and miso-soup (n = 498)” groups. In multiple liner regression models, birth weight was 22.6 g (95%CI: 0.1 to 45.2 g) heavier in “high in fruits” group than in reference group and 39.4 g (95%CI: 8.6 to 70.3 g) lighter in “high in coffee” group than in reference group. The other groups were not statistically significant.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>High consumption of fruits and high consumption of coffee, black tea, soft drinks and confections during early pregnancy were associated with increased and decreased birth weight, respectively.</jats:p> </jats:sec> <jats:sec> <jats:title>Key messages</jats:title> <jats:p>We found maternal dietary patterns during early pregnancy using a machine learning method of k-means clustering algorithm. We found maternal dietary patterns which associated with the birth weight in Japan.</jats:p> </jats:sec>
Interannual Changes in the Prevalence of Intimate Partner Violence Against Pregnant Women in Miyagi Prefecture After the Great East Japan Earthquake: The Japan Environment and Children's Study. 国際誌査読有り

Kaou Tanoue, Hidekazu Nishigori, Zen Watanabe, Kosuke Tanaka, Kasumi Sakurai, Satoshi Mizuno, Mami Ishikuro, Taku Obara, Masahito Tachibana, Tetsuro Hoshiai, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Journal of interpersonal violence　36　(21-22)　886260519881517-886260519881517　2019年10月16日

DOI： 10.1177/0886260519881517 　

ISSN：0886-2605

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This study aimed to clarify the interannual changes in intimate partner violence against pregnant women after the March 11, 2011 Great East Japan Earthquake in target areas of Miyagi Prefecture that were damaged by the earthquake and tsunami. Because of this disaster, in Miyagi Prefecture, approximately 12,000 people died or went missing, and approximately 238,000 buildings were destroyed. According to the U.S. Geological Survey, the Great East Japan Earthquake is the fourth largest earthquake in the world and the largest in Japan since 1900. The present study was part of the Japan Environment and Children's Study. Data from June 2011 to May 2014 of 79,222 pregnant women were analyzed, calculating the prevalence of physical and mental intimate partner violence in the inland, north coastal, and south coastal areas of Miyagi. These prevalence rates were compared with nationwide rates of intimate partner violence in 2011 using univariate and logistic regression analyses. After the disaster, the incidence of mental intimate partner violence increased in the south coastal area and then improved later (19.4%, 13.1%, and 13.3% for south coastal area, and 13.8%, 13.8%, and 13.1% for nationwide in 2011, 2012, and 2013, respectively). However, in the north coastal area, the incidence of physical intimate partner violence increased after the disaster and then improved later (2.7%, 1.5%, and 1.3% for north coastal area, and 1.4%, 1.3%, and 1.1% for nationwide in 2011, 2012, and 2013, respectively). In the inland area, however, the prevalence of both mental and physical intimate partner violence was consistently higher than nationwide rates after the disaster.
TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

寳澤篤, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 布施昇男, 山本雅之

日本公衆衛生学会総会抄録集　78回　212-212　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
6.3万人データ分譲に向けて東北メディカル・メガバンク計画地域住民コホート調査

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 村上慶子, 小原拓, 中谷直樹, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　78回　212-212　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討東北メディカル・メガバンク計画コホート調査の成果から

小暮真奈, 平田匠, 土屋菜歩, 中村智洋, 宮川健, 小清水宏, 小原拓, 目時弘仁, 宇留野晃, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　287-287　2019年10月
出版者・発行元： (NPO)日本高血圧学会
非喫煙者における受動喫煙の有無と家庭高血圧の関連

平田匠, 小暮真奈, 成田暁, 佐藤倫広, 土屋菜歩, 中村智洋, 宇留野晃, 小原拓, 目時弘仁, 中谷直樹, 菅原準一, 栗山進一, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　288-288　2019年10月
出版者・発行元： (NPO)日本高血圧学会
本態性高血圧患者における治療前および降圧治療中の家庭血圧指標の予後予測能 HOMED-BP研究査読有り

渡部大介, 浅山敬, 花澤智大, 保坂実樹, 佐藤倫広, 安井大策, 小原拓, 井上隆輔, 目時弘仁, 菊谷昌浩, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　42回　223-223　2019年10月
出版者・発行元： (NPO)日本高血圧学会
Inadequate Folic Acid Intake Among Women Taking Antiepileptic Drugs During Pregnancy in Japan: A Cross-Sectional Study. 国際誌査読有り

Yasuko Ikeda-Sakai, Yoshiyuki Saito, Taku Obara, Mikako Goto, Tami Sengoku, Yoshimitsu Takahashi, Hiromi Hamada, Takeo Nakayama, Atsuko Murashima

Scientific reports　9　(1)　13497-13497　2019年9月18日

DOI： 10.1038/s41598-019-49782-x 　

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This study aimed to assess characteristics of pregnant women taking antiepileptic drugs with inadequate folic acid intake. This cross-sectional study examined pregnant women taking antiepileptic drugs who were registered in the Japanese Drug Information Institute in Pregnancy (JDIIP) database between October 2005 and December 2016. Participants were classified into two groups according to when they started folic acid supplementation (before pregnancy: 'adequate', after pregnancy or never: 'inadequate'). Logistic regression analysis was performed to investigate factors associated with inadequate folic acid intake. Of 12,794 registrants, 468 pregnant women were taking antiepileptics during the first trimester. Of these, we analysed data from 456 women who had no missing data. As a result, inadequate folic acid intake was noted among 83.3% of them, suggesting that the current level of folic acid intake is insufficient overall. Younger age, smoking, alcohol drinking, multiparity, unplanned pregnancy, and being prescribed AEDs by paediatric or psychiatric departments were independent factors associated with inadequate folic acid intake. As planned pregnancy was the strongest factor, healthcare professionals should ensure that childbearing women taking antiepileptics are informed of the importance of planned pregnancy. In addition, healthcare professionals must gain a better understanding of folic acid intake, as the prevalence of adequate intake differed according to which departments prescribed antiepileptic drugs.
Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study. 国際誌査読有り

Michihiro Satoh, Hirohito Metoki, Kei Asayama, Takahisa Murakami, Ryusuke Inoue, Megumi Tsubota-Utsugi, Ayako Matsuda, Takuo Hirose, Azusa Hara, Taku Obara, Masahiro Kikuya, Kyoko Nomura, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

Journal of the American Heart Association　8　(15)　e012121　2019年8月6日

DOI： 10.1161/JAHA.119.012121 　

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Background Home blood pressure is a more accurate prognosticator than office blood pressure and allows the observation of day-to-day blood pressure variability. Information on blood pressure change during the life course links the prediction of blood pressure elevation with age. We prospectively assessed age-related trends in home blood pressure, home pulse rate, and their day-to-day variability evaluated as a coefficient of variation. Methods and Results We examined 1665 participants (men, 36.0%; mean age, 56.2 years) from the general population of Ohasama, Japan. A repeated-measures mixed linear model was used to estimate the age-related trends. In a mean of 15.9 years, we observed 5438 points of measurements including those at baseline. The home systolic blood pressure linearly increased with age and was higher in men than in women aged <70 years. There was an inverse-U-shaped age-related trend in home diastolic blood pressure. The day-to-day home systolic blood pressure linearly increased with age in individuals aged >40 years. However, an U-shaped age-related trend in day-to-day diastolic blood pressure variability with the nadir point at 65 to 69 years of age was observed. No significant sex differences in the day-to-day blood pressure variability were observed (P≥0.22). The average and day-to-day variability of home pulse rate decreased with age but were lower and higher, respectively, in men than in women. Conclusions The current descriptive data are needed to predict future home blood pressure and pulse rate. The data also provide information on the mechanism of day-to-day blood pressure and pulse rate variability.
A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. 国際誌査読有り

Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Fuji Nagami, Naoko Minegishi, Soichi Ogishima, Takako Takai-Igarashi, Inaho Danjoh, Taku Obara, Mami Ishikuro, Tomoko Kobayashi, Yayoi Aizawa, Rino Ishihara, Masayuki Yamamoto, Yoichi Suzuki

BMC medical education　19　(1)　297-297　2019年8月2日

DOI： 10.1186/s12909-019-1725-5 　

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BACKGROUND: Genome cohort studies are used to analyze interactions between genetic and environmental factors, providing valuable information for personalized healthcare. Large-scale and long-term cohort studies require a number of specially trained personnel, of whom those involved in obtaining informed consent play a vital role, especially during the initial phase of such studies. The Japanese Society of Human Genetics (JSHG) previously established a certification system for genome medical research coordinators (GMRCs) responsible for obtaining written consent via face-to-face explanation. Meanwhile, in the Tohoku Medical Megabank Organization (ToMMo), GMRCs are expected to play important roles not only in obtaining informed consent and conducting various assessments, but also in communicating with participants throughout the long-term follow-up. Based on the JSHG program, we therefore developed a specific education and training program for ToMMo GMRCs consisting of 17 lectures, one practical training session on the informed consent procedure, and written and interview examinations. Re-education workshops aimed at self-improvement are also carried out following certification. In this study, we evaluated the education and training program in terms of overall understanding, usefulness, and satisfaction using an anonymous questionnaire. METHODS: An anonymous questionnaire addressing each aspect of the education and training program (understanding, usefulness, and satisfaction) was distributed among 152 qualified ToMMo GMRCs. Responses were received from 94 participants (61.8%). RESULTS: There was a significant association between the level of overall understanding of lectures and medical qualification (nurse or clinical laboratory technologist), but not with age or educational background. The level of understanding and overall usefulness were lower in sessions related to genetics and epidemiology than those dealing with ToMMo practices. In the re-education workshops, GMRCs showed a preference for and hoped to learn more about both background knowledge and research progress in the ToMMo. CONCLUSIONS: The results of our questionnaire suggest that not all ToMMo GMRCs are able to understand everything during the initial education and training program, especially in terms of genomic medicine. Continuous re-education is therefore vital in improving knowledge, skills and motivation, and preparing GMRCs for a specialist role in community-based personalized healthcare.
Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes

Wen-Yi Yang, Jesus D. Melgarejo, Lutgarde Thijs, Zhen-Yu Zhang, Jose Boggia, Fang-Fei Wei, Tine W. Hansen, Kei Asayama, Takayoshi Ohkubo, Jorgen Jeppesen, Eamon Dolan, Katarzyna Stolarz-Skrzypek, Sofia Malyutina, Edoardo Casiglia, Lars Lind, Jan Filipovsky, Gladys E. Maestre, Yan Li, Ji-Guang Wang, Yutaka Imai, Kalina Kawecka-Jaszcz, Edgardo Sandoya, Krzysztof Narkiewicz, Eoin O'Brien, Peter Verhamme, Jan A. Staessen, B. Mujaj, N. Cauwenberghs, T. Kuznetsova, W. -Y. Yang, C. -G. Yu, C. -S. Sheng, Q. -F. Huang, J. Seidlerova, M. Ticha, H. Ibsen, S. Rasmussen, C. Torp-Pedersen, A. Pizzioli, V. Tikhonoff, J. Hashimoto, H. Hoshi, R. Inoue, M. Kikuya, H. Metoki, T. Obara, H. Satoh, K. Totsune, N. Gilis-Malinowska, A. Adamkiewicz-Piejko, M. Cwynar, J. Gasowski, T. Grodzicki, W. Lubaszewski, A. Olszanecka, B. Wizner, W. Wojciechowska, J. Zyczkowska, Y. Nikitin, E. Pello, G. Simonova, M. Voevoda, B. Andren, L. Berglund, K. Bjorklund-Bodegard, B. Zethelius, M. Bianchi, V. Moreira, C. Schettini, E. Schwedt, H. Senra

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION　322　(5)　409-420　2019年8月

DOI： 10.1001/jama.2019.9811 　

ISSN：0098-7484

eISSN：1538-3598
母子保健情報と学校保健情報の連係に基づく発育指標の関連

上野史彦, 小原拓, 村上慶子, 野田あおい, 大柳元, 石黒真美, 目時弘仁, 黒川修行, 栗山進一

東北公衆衛生学会誌　(68)　20-20　2019年7月
出版者・発行元：東北公衆衛生学会
ISSN：0915-549X
Association of Feeding Practice with Childhood Overweight and/or Obesity in Affected Areas Before and After the Great East Japan Earthquake. 査読有り

Kuniyoshi Y, Kikuya M, Matsubara H, Ishikuro M, Obara T, Kure S, Kuriyama S

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine　14　(6)　382-389　2019年7月
出版者・発行元：
DOI： 10.1089/bfm.2018.0254 　

ISSN：1556-8253

eISSN：1556-8342
Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study. 国際誌査読有り

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Mami Ishikuro, Kasumi Sakurai, Tetsuro Hoshiai, Masatoshi Saito, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nariyasu Mano, Hirohito Metoki, Nobuo Yaegashi

Congenital anomalies　59　(4)　110-117　2019年7月

DOI： 10.1111/cga.12293 　

ISSN：0914-3505

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We evaluated the relationship between preconception folic acid supplementation and the occurrence of neural tube defects (NTDs) in offspring, using data from the Japan Environment and Children's Study (a nationwide prospective birth cohort study) database. Of 92 269 participants with single pregnancies, 74 cases (offspring or fetuses) had NTDs, including 32 cases of spina bifida, 24 cases of anencephaly, and 19 cases of encephalocele. A total of 7634 participants (8.27%) used preconception folic acid supplementation, and of these, 621 (0.67%) also took in dietary folic acid at ≥480 μg/day. Multivariate logistic regression analyses demonstrated no association between preconception folic acid supplementation and NTDs in offspring or fetuses (odds ratio [OR] 0.622; 95% confidence interval [CI]: 0.226-1.713). Moreover, the participants who combined preconception folic acid supplement use with dietary folic acid intake ≥480 μg/day demonstrated no incidence of NTDs in offspring or fetuses. Our analysis is limited by the absence of the data on the daily amount of supplementary folic acid intake, requiring careful attention to the interpretation. Additional surveys are required in Japan to resolve those limitations for further comprehensive assessment.
Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database. 国際誌査読有り

Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Masato Suzuka, Yasuko Ikeda-Sakai, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Pharmacoepidemiology and drug safety　28　(6)　804-811　2019年6月

DOI： 10.1002/pds.4749 　

ISSN：1053-8569

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PURPOSE: To evaluate the prevalence and patterns of prescriptions of antiepileptic drugs (AEDs) to prenatal and postpartum women in Japan using a large administrative database. METHODS: The dates of pregnancy onset and delivery were estimated using published algorithms and infant birth months. The prevalence of prescribed AEDs, the maximum dose of some AEDs, and the frequency of potential combination therapy with AEDs were evaluated for the 180 days before pregnancy onset, during pregnancy, and at 180-day postpartum. RESULTS: In total, 33 941 pregnant women were eligible for analysis. At least one AED was prescribed to 225 women (66 per 10 000 deliveries) between 180 days before pregnancy and 180-day postpartum and for 135 women (40 per 10 000 deliveries) during pregnancy. The prevalence of AED prescription declined during the first and second trimesters and increased in the third trimester and postpartum. Valproate was the most frequently prescribed drug, followed by clonazepam, lamotrigine, and carbamazepine. Nine (18.4%) of the 49 women with at least one prescription record of valproate in the first trimester were prescribed more than 600 mg/day of valproate. Concerning potential combination therapy, 40 (12 per 10 000 deliveries) concurrently received two or more AEDs between 180 days before pregnancy and 180-day postpartum, respectively, 31 (9 per 10 000 deliveries) women received these drugs during pregnancy. CONCLUSIONS: Various AEDs were prescribed to pregnant Japanese women. Women of reproductive age should select the appropriate AED before becoming pregnant, depending on the risk benefit profile.
Mother-to-infant bonding failure and intimate partner violence during pregnancy as risk factors for father-to-infant bonding failure at 1 month postpartum: an adjunct study of the Japan Environment and Children's Study. 国際誌査読有り

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(16)　1-8　2019年4月15日

DOI： 10.1080/14767058.2018.1560414 　

ISSN：1476-7058

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OBJECTIVE: To survey the frequency and risk factors for father-to-infant lack of affection (LA) and anger/rejection (AR) bonding failure at 1 month postpartum. MATERIAL AND METHODS: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment & Children's Study. Bonding failure, psychological distress during pregnancy and postnatal depression symptoms were evaluated using the Japanese version of the Mother-Infant Bonding Scale (MIBS-J), the Kessler 6-item (K6) psychological distress scale and the Edinburgh Postnatal Depression Scale (EPDS-J). This study extracted relative factors based on approximately 10% occupancy of the total high scores in MIBS-J subscales as a cut-off for bonding failure. The cut-off scores on the paternal EPDS-J were eight, on maternal EPDS-J was 9, and on the K6 psychological distress scale score was 13. RESULTS: A total of 1008 couples who had single delivery were assessed at 1 month postpartum, respectively. The prevalence of paternal MIBS-J_LA scores ≥4 was 8.3%, MIBS-J_AR scores ≥3 was 7.9%, and EPDS-J scores ≥8 was 11.2%, respectively. In the multiple logistics analysis, paternal MIBS-J_LA scores ≥4 were significantly associated with maternal MIBS-J_LA score ≥3 (adjusted odds ratio (AOR) 2.814; 95% confidence interval (CI): 1.377-5.747), mental intimate partner violence (IPV) against the mother during pregnancy (AOR 2.176; 95% CI: 1.185-3.997), maternal K6 psychological distress scale score ≥13 (AOR 2.980; 95% CI: 1.317-6.745), paternal EPDS-J score ≥8 (AOR 3.227; 95% CI: 1.767-5.892), and a history of mental health disorder (AOR 4.125; 95% CI: 1.423-11.963). Paternal MIBS-J_AR scores ≥3 were significantly associated with maternal MIBS-J_AR scores ≥3 (AOR 5.082; 95% CI: 2.453-10.529), a history of physical IPV against the mother during pregnancy (AOR 5.230; 95% CI: 1.016-26.920), paternal K6 psychological distress scale score ≥13 (AOR 4.145; 95% CI: 1.311-13.107), and paternal EPDS-J scores ≥8 (AOR 4.479; 95% CI: 2.503-8.013). In Pearson's product moment correlation coefficient analyses between paternal and maternal MIBS-J score, MIBS-J_LA score was r = 0.2112, p < .0001, and MIBS-J_AR score was r = 0.3281, p < .0001. CONCLUSION: Father-to-infant lack of affection bonding failure was associated with mother-to-infant lack of affection bonding failure, mental IPV against mother during pregnancy, maternal psychological distress during pregnancy, paternal postpartum depression symptoms, and history of paternal mental health disorders. Father-to-infant anger/rejection bonding failure was associated with mother-to-infant anger/rejection bonding failure, physical IPV against mother during pregnancy, paternal psychological distress during pregnancy, and paternal postpartum depression symptoms. Since bonding failure is a risk factor for infant maltreatment, further investigations are recommended to fully assess these associations to resolve parent perinatal mental health issues for preventing father-to-infant bonding failure.
Effect of Educational Interventions on Adverse Drug Reaction Reporting in a Cancer Institute in Japan: A Questionnaire Study 査読有り

Masami Tsuchiya, Akihisa Esashi, Taku Obara, Kyoko Inooka, Nariyasu Mano, Chizuko Takamura

Hospital Pharmacy　54　(2)　93-99　2019年4月

DOI： 10.1177/0018578718769242 　

ISSN：0018-5787

eISSN：1945-1253
Effect of Educational Interventions on Adverse Drug Reaction Reporting in a Cancer Institute in Japan: A Questionnaire Study. 国際誌査読有り

Masami Tsuchiya, Akihisa Esashi, Taku Obara, Kyoko Inooka, Nariyasu Mano, Chizuko Takamura

Hospital pharmacy　54　(2)　93-99　2019年4月

DOI： 10.1177/0018578718769242 　

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Background: Limited data regarding knowledge and factors related to understanding the adverse drug reaction (ADR) reporting system of health care professionals are available in Japan. Objective: The objective of this study was to identify factors related to understanding the ADR reporting system in Miyagi Cancer Center and to find ways to increase the number and quality of ADR reports. Methods: Self-administered questionnaire surveys were administered before and after the educational meeting among health care professionals who were working in our hospital during the study period. Subanalyses restricted to nurses were also performed. Main Outcome Measure: Understanding ADR reporting system among healthcare professionals. Results: The percentage of respondents who understood the ADR reporting system in the questionnaire after the educational meeting was significantly higher than that in the questionnaire before the educational meeting. In the questionnaire after the educational meeting, multivariate logistic regression analysis found that having over 30 years of practical experience (odds ratio [OR], 3.852; 95% confidence interval [CI], 1.228-12.081 for 20-29 years, 7.695; 1.650-35.881 for over 30 years), being a physician (8.071; 1.923-33.878), being a pharmacist (18.357; 3.847-87.585), and participating in the educational meeting (5.111; 1.700-15.365) were factors associated with understanding the ADR reporting system. Multivariate logistic regression analysis of the questionnaire results before the educational meeting among nurses showed that working at outpatient departments (8.330; 3.008-23.069) was significantly and independently associated with understanding the ADR reporting system. Conclusions: The present study demonstrated that many years of practical experience, profession (physicians, pharmacists), and educational interventions were associated with good understanding of the ADR reporting system among health care professionals.
Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. 国際誌査読有り

Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Hirotaka Hamada, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　42　(4)　558-566　2019年4月

DOI： 10.1038/s41440-019-0206-x 　

ISSN：0916-9636

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Smoking during pregnancy is a risk factor for various adverse birth outcomes but lowers the risk of preeclampsia. Cardiovascular adaptations might underlie these associations. We examined the association of maternal smoking with the risk of hypertensive disorders of pregnancy (HDP) in a low-risk population-based cohort of 76,303 pregnant women. This study was a part of the Japan Environment and Children's Study. Smoking status was assessed using questionnaires completed by participants. Information about HDP was assessed using questionnaires completed by doctors. Compared with that for women who did not smoke, women who continued smoking >10 cigarettes per day during pregnancy had a significantly higher risk of developing HDP (odds ratio: 1.58, 95% confidence interval: 1.11-2.25). In multivariate analyses with adjustment for possible confounding factors, the association still remained (odds ratio: 1.51, 95% confidence interval: 1.04-2.19). When we regarded the number of cigarettes as a continuous variable, there was a linear association between the number of cigarettes and risk of HDP, with an odds ratio of 1.02 per cigarette per day (95% confidence interval: 1.00-1.04). Smoking a greater number of cigarettes was associated with a higher risk of HDP after adjustment for possible confounding factors. Cigarette smoking cessation may avoid the complications of HDP. Our findings suggest that, in addition to the risk of small-for-gestational-age children, an increased risk of HDP should be considered in the management of pregnant women who smoke cigarettes.
The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. 国際誌査読有り

Hiromitsu Hattori, Akane Kitamura, Fumiaki Takahashi, Norio Kobayashi, Akiko Sato, Naoko Miyauchi, Hidekazu Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi, Kunihiko Nakai, Takahiro Arima

Reproductive biology and endocrinology : RB&E　17　(1)　27-27　2019年2月22日

DOI： 10.1186/s12958-019-0471-1 　

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BACKGROUND: Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the association between blastocyst transfer and SSR and MZT, considering potential parental confounders. METHODS: The Japan Environment and Children's Study is a large, nationwide longitudinal birth cohort study funded by the Ministry of the Environment of Japan. We used this large dataset, including 103,099 pregnancies, to further investigate the association between blastocyst transfer, SSR and MZT, using spontaneously conceived pregnancies, non-assisted reproductive technology (non-ART) treatment (intrauterine insemination and ovulation induction with timed intercourse) and cleavage stage embryo transfer for comparison. We evaluated the association with each group, the SSR, and the frequency of MZT, calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses, adjusting for potential parental confounders such as basic health and socioeconomic status. RESULTS: For each group (spontaneous conception vs. non-ART treatment vs. cleavage stage embryo transfer vs. blastocyst transfer), the percentages of males were 51.3% vs 50.7% vs 48.9% vs 53.4% and the monozygotic twinning rates per pregnancy were 0.27% vs 0.11% vs 0.27% vs 0.99% respectively. Multivariate logistic regression analyses indicated that blastocyst transfer was significantly associated with a higher SSR and higher incidence of MZT than the other three groups (SSR: AOR 1.095, 95% CI1.001-1.198; MZT: AOR 4.229, 95% CI 2.614-6.684). CONCLUSIONS: There are significant relationships between blastocyst transfer and SSR imbalance and a higher occurrence of MZT.
Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. 国際誌査読有り

Junichi Sugawara, Daisuke Ochi, Riu Yamashita, Takafumi Yamauchi, Daisuke Saigusa, Maiko Wagata, Taku Obara, Mami Ishikuro, Yoshiki Tsunemoto, Yuki Harada, Tomoko Shibata, Takahiro Mimori, Junko Kawashima, Fumiki Katsuoka, Takako Igarashi-Takai, Soichi Ogishima, Hirohito Metoki, Hiroaki Hashizume, Nobuo Fuse, Naoko Minegishi, Seizo Koshiba, Osamu Tanabe, Shinichi Kuriyama, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Satoshi Hiyama, Masao Nagasaki

BMJ open　9　(2)　e025939　2019年2月19日

DOI： 10.1136/bmjopen-2018-025939 　

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PURPOSE: A prospective cohort study for pregnant women, the Maternity Log study, was designed to construct a time-course high-resolution reference catalogue of bioinformatic data in pregnancy and explore the associations between genomic and environmental factors and the onset of pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes mellitus and preterm labour, using continuous lifestyle monitoring combined with multiomics data on the genome, transcriptome, proteome, metabolome and microbiome. PARTICIPANTS: Pregnant women were recruited at the timing of first routine antenatal visits at Tohoku University Hospital, Sendai, Japan, between September 2015 and November 2016. Of the eligible women who were invited, 65.4% agreed to participate, and a total of 302 women were enrolled. The inclusion criteria were age ≥20 years and the ability to access the internet using a smartphone in the Japanese language. FINDINGS TO DATE: Study participants uploaded daily general health information including quality of sleep, condition of bowel movements and the presence of nausea, pain and uterine contractions. Participants also collected physiological data, such as body weight, blood pressure, heart rate and body temperature, using multiple home healthcare devices. The mean upload rate for each lifelog item was ranging from 67.4% (fetal movement) to 85.3% (physical activity), and the total number of data points was over 6 million. Biospecimens, including maternal plasma, serum, urine, saliva, dental plaque and cord blood, were collected for multiomics analysis. FUTURE PLANS: Lifelog and multiomics data will be used to construct a time-course high-resolution reference catalogue of pregnancy. The reference catalogue will allow us to discover relationships among multidimensional phenotypes and novel risk markers in pregnancy for the future personalised early prediction of pregnancy complications.
Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. 国際誌査読有り

Zen Watanabe, Hidekazu Nishigori, Kaou Tanoue, Kosuke Tanaka, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Masatoshi Saito, Masahito Tachibana, Ikuma Fujiwara, Takahiro Arima, Takashi Takeda, Shinichi Kuriyama, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Journal of affective disorders　245　475-483　2019年2月15日

DOI： 10.1016/j.jad.2018.11.061 　

ISSN：0165-0327

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BACKGROUND: Dysmenorrhea influences emotional distress as well as physical suffering in young non-pregnant women. The aim of this study was to assess the potential association between preconception dysmenorrhea and the development of psychological distress during pregnancy. METHODS: This study was a part of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study conducted between 2011 and 2014 in Japan. A total of 87,102 pregnant Japanese women with no psychological distress (Kessler 6-item psychological distress scale [K6] score ≤ 12) in early pregnancy were eligible. Among these, 7626 had mild and 1638 had severe preconception dysmenorrhea. The prevalence and risk of maternal psychological distress (K6 scores ≥ 13) in the second or third trimester were compared among preconception dysmenorrhea severity groups. RESULTS: A higher percentage of women with mild (2.6%) or severe preconception dysmenorrhea (3.6%) suffered psychological distress during pregnancy compared to that in women without dysmenorrhea (2.1%). A multilevel logistic regression model, adjusting for baseline characteristics and the K6 score at enrollment, showed that the severity of dysmenorrhea was associated with psychological distress (mild dysmenorrhea: adjusted odds ratio [aOR], 1.154; 95% confidence interval [95% CI], 0.980-1.359; and severe dysmenorrhea: aOR, 1.457; 95% CI, 1.087-1.951). LIMITATIONS: Information about dysmenorrhea was obtained during early pregnancy. The JECS did not have clear diagnostic criteria for dysmenorrhea. CONCLUSIONS: Preconception dysmenorrhea is associated with an elevated incidence of psychological distress during pregnancy. Additionally, expectant mothers with a history of severe dysmenorrhea symptoms before pregnancy have a higher risk of developing psychological distress.
The prevalence and risk factors for postpartum depression symptoms of fathers at one and 6 months postpartum: an adjunct study of the Japan Environment & Children's Study. 国際誌査読有り

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(16)　1-8　2019年1月4日

DOI： 10.1080/14767058.2018.1560415 　

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OBJECTIVE: To survey prevalence and risk factors for paternal postpartum depression symptoms at one and 6 months postpartum in Japan. MATERIAL AND METHODS: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment and Children's Study. Postpartum depression symptoms were evaluated using the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS-J). The cut-off scores on the paternal EPDS-J were eight and on maternal EPDS-J was nine, respectively. The multivariate logistic regression included an adjustment for paternal age, maternal age, the number of children in the family, family structure, paternal employment, paternal academic history, household income, paternal smoking status, paternal history of mental health disorders, the Kessler 6-item psychological distress scale (K6) score during pregnancy, infertility treatment, paternal mental intimate partner violence (IPV) during pregnancy, paternal physical IPV during pregnancy, the sex of the newborn, congenital anomalies of the newborn, infant disease under medical treatment, returning to the maternal parent's house to give birth or take care of infant, the father's history of disease or injury that required medical treatment, paternity leave, and the EPDS-J for mothers. RESULTS: A total of 1023 and 1330 fathers and their spouse who had a single delivery were assessed at one and 6 months postpartum, respectively. The prevalence of paternal EPDS-J scores ≥8 was 11.2 and 12.0% at one and 6 months postpartum, respectively. In the multiple logistics analysis, paternal EPDS-J scores ≥8 at 1 month postpartum was significantly associated with history of mental health disorders (adjusted odds ratio (AOR) 2.825; 95% confidence interval (CI): 1.047-7.623), K6 score ≥13 during pregnancy (AOR 4.116; 95% CI: 1.598-10.599), household income <4000 × 103 yen (AOR 1.799; 95% CI: 1.072-3.021), and infant disease under medical treatment (AOR 1.720; 95% CI: 1.015-2.915). Paternal EPDS-J scores ≥8 at 6 months postpartum was significantly associated with K6 scores ≥13 during pregnancy (AOR 4.621; 95% CI: 2.113-10.107), unemployment (AOR 3.751; 95% CI: 1.739-8.091) and maternal EPDS-J scores ≥9 (AOR 2.460; 95% CI: 1.514-3.996). CONCLUSION: The prevalence of paternal postpartum depression symptoms were 11.2 and 12.0% at one and 6 months postpartum. Paternal postpartum depression symptoms at 1 month postpartum were associated with the history of mental health disorders, psychological distress during pregnancy, low income, and infant disease under medical treatment. Paternal postpartum depression symptoms at 6 months postpartum were associated with psychological distress during pregnancy, unemployment, and maternal postpartum depression. It is important to consider the paternal postpartum depression symptoms, and further enlightenment regarding these issues is recommended in Japan.
Responder Analysis of Daikenchuto Treatment for Constipation in Poststroke Patients: A Subanalysis of a Randomized Control Trial

Ryutaro Arita, Takehiro Numata, Shin Takayama, Taku Obara, Akiko Kikuchi, Minoru Ohsawa, Akifumi Suzuki, Takashi Yokota, Mizue Kusaba, Nobuo Yaegashi, Tadashi Ishii

Journal of Evidence-Based Integrative Medicine　24　2019年

DOI： 10.1177/2515690X19889271 　

eISSN：2515-690X
Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. 国際誌査読有り

Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

Journal of hypertension　37　(1)　206-215　2019年1月

DOI： 10.1097/HJH.0000000000001846 　

ISSN：0263-6352

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OBJECTIVES: Although a twin pregnancy is a risk factor for hypertensive disorders of pregnancy, studies investigating longitudinal blood pressure changes during twin pregnancies are uncommon. The aims of this study were to evaluate the longitudinal blood pressure changes during twin pregnancies and to compare blood pressure levels between twin and singleton pregnancies. METHODS: Five hundred dichorionic diamniotic twin, 240 monochorionic diamniotic twin, and 80 775 singleton pregnancies were included in this Japanese prospective birth cohort study. A marginal model was applied to evaluate the SBP, DBP, and mean arterial pressure levels during early gestation, mid-gestation, and late gestation. RESULTS: The blood pressure levels fell from early-to-mid-gestation and rose after mid-gestation in the dichorionic and monochorionic diamniotic twin pregnancies. The SBP and mean arterial pressure levels during early gestation and the DBP and mean arterial pressure levels during late gestation were higher in the dichorionic diamniotic twin pregnancies than those in the singleton pregnancies. The blood pressure levels in the monochorionic diamniotic twin pregnancies were higher than those in the singleton pregnancies at each gestational stage, except for the SBP during late gestation. CONCLUSION: Although the longitudinal blood pressure changes during twin pregnancies were similar to those during singleton pregnancies, the blood pressure levels during twin pregnancies were higher. Further studies that examine the associations between the longitudinal blood pressure changes during pregnancy and the perinatal outcomes in twin pregnancies are necessary.
Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study. 国際誌査読有り

Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

Hypertension research : official journal of the Japanese Society of Hypertension　42　(1)　85-94　2019年1月

DOI： 10.1038/s41440-018-0124-3 　

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This study examined the association between maternal alcohol consumption during pregnancy and hypertensive disorders of pregnancy in the Japan Environment and Children's Study, a nationwide birth cohort study. A total of 76 940 pregnant women were included in the analysis. Information about alcohol consumption during pregnancy was obtained using two questionnaires: T1 and T2. The mean (standard deviation) gestational age in the T1 and T2 questionnaires were 16.5 (5.8) and 27.9 (3.7) weeks, respectively. Alcohol consumption was considered as an exposure, hypertensive disorders of pregnancy as an outcome, and possible confounding factors were included in a generalized linear mixed-effects model with a logit link function. Among the study subjects, 2 348 (3.1%) women developed hypertensive disorders of pregnancy. Compared with 25 300 women who never drank alcohol, 43 women who drank alcohol according to the T1 questionnaire and continued to drink ≥150 g ethanol/week according to the T2 questionnaire had significantly higher odds of hypertensive disorders of pregnancy. The adjusted odds ratio was 3.98 (95% confidence interval [CI], 1.33-11.9). In conclusion, alcohol consumption of ≥150 g ethanol/week during pregnancy is better avoided because of the high odds of developing hypertensive disorders of pregnancy. It may be meaningful that healthcare providers confirm information about alcohol consumption during pregnancy. Moreover, discontinuation of alcohol consumption is recommended to prevent the onset of hypertensive disorders of pregnancy in Japan.
Development and evaluation of a home nocturnal blood pressure monitoring system using a wrist-cuff device. 国際誌査読有り

Yutaka Imai, Kei Asayama, Seisuke Fujiwara, Kanako Saito, Hironori Sato, Toshikazu Haga, Michihiro Satoh, Takahisa Murakami, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Ryusuke Inoue, Takayoshi Ohkubo

Blood pressure monitoring　23　(6)　318-326　2018年12月

DOI： 10.1097/MBP.0000000000000351 　

ISSN：1359-5237

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OBJECTIVE: The conventional nocturnal blood pressure monitoring (NBPM) systems can disturb sleep and lead to false measurements. The present study compared the validity and acceptability of a newly developed wrist-cuff system with that of the conventional upper arm-cuff system for NBPM. PARTICIPANTS AND METHODS: Home blood pressure (BP) and pulse rate (PR) were measured in hypertensive patients (n=57) every 30 min at night using a wrist-cuff system and at 2 am (fixed time) and 4 h after going to bed (flexible time) using an upper arm-cuff system. The nocturnal BPs with the wrist-cuff system at 2 am and at 4 h after going to bed were selected from the measurements taken every 30 min at night. The same systems were used to measure the morning and evening home BP and PR, after rising and before going to bed. Measurements were taken for two nights separately for each system. BP, PR, sleep quality, and the perception of several stimuli during NBPM were compared between the two systems. Systolic BP/diastolic BP (DBP) in the supine position at 2 am and at 4 h after going to bed were corrected by the mean difference between the wrist-cuff and the arm-cuff systems. RESULTS: Compared with the arm-cuff system, the wrist-cuff system had significantly lower systolic BP (mean±SD: 106.3±13.4 vs. 109.8±10.8 mmHg, P<0.05), DBP (59.4±11.0 vs. 64.5±7.8 mmHg, P<0.005), and PR (53.8±7.1 vs. 60.5±8.1 bpm, P<0.0005) at 2 am and significantly lower DBP (60.2±10.3 vs. 66.0±9.8 mmHg, P<0.005) and PR (53.6±7.4 vs. 60.9±8.5 bpm, P<0.0005) at 4 h after going to bed. Among the participants, sleep disturbance during NBPM was reported in less than 20% with the wrist-cuff system and in 70% with the arm-cuff system. A significantly higher rate of participants who wore the wrist-cuff system reported that they were not bothered by various stimuli, such as noise, during NBPM. DISCUSSION: The newly developed wrist-cuff home NBPM system provided information on BP as a function of time, especially at night, with minimal sleep disturbance and with more frequent BP measurements.
Antihypertensives prescribed for pregnant women in Japan: Prevalence and timing determined from a database of health insurance claims. 国際誌査読有り

Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Keiko Miyakoda, Mami Ishikuro, Hirohito Metoki, Takayoshi Ohkubo, Junichi Sugawara, Nobuo Yaegashi, Manabu Akazawa, Shinichi Kuriyama, Nariyasu Mano

Pharmacoepidemiology and drug safety　27　(12)　1325-1334　2018年12月

DOI： 10.1002/pds.4654 　

ISSN：1053-8569
薬剤師に求められる医薬品安全性情報の創出

小原拓, 眞野成康, 堀雄史

日本医療薬学会年会講演要旨集　28　337-341　2018年11月23日
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.28.0_337 　

eISSN：2424-2470
Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods. 国際誌査読有り

Taku Obara, Mami Ishikuro, Gen Tamiya, Masao Ueki, Chizuru Yamanaka, Satoshi Mizuno, Masahiro Kikuya, Hirohito Metoki, Hiroko Matsubara, Masato Nagai, Tomoko Kobayashi, Machiko Kamiyama, Mikako Watanabe, Kazuhiko Kakuta, Minami Ouchi, Aki Kurihara, Naru Fukuchi, Akihiro Yasuhara, Masumi Inagaki, Makiko Kaga, Shigeo Kure, Shinichi Kuriyama

Scientific reports　8　(1)　14840-14840　2018年10月4日

DOI： 10.1038/s41598-018-33110-w 　

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We investigated whether machine learning methods could potentially identify a subgroup of persons with autism spectrum disorder (ASD) who show vitamin B6 responsiveness by selected phenotype variables. We analyzed the existing data from our intervention study with 17 persons. First, we focused on signs and biomarkers that have been identified as candidates for vitamin B6 responsiveness indicators. Second, we conducted hypothesis testing among these selected variables and their combinations. Finally, we further investigated the results by conducting cluster analyses with two different algorithms, affinity propagation and k-medoids. Statistically significant variables for vitamin B6 responsiveness, including combination of hypersensitivity to sound and clumsiness, and plasma glutamine level, were included. As an a priori variable, the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) scores was also included. The affinity propagation analysis showed good classification of three potential vitamin B6-responsive persons with ASD. The k-medoids analysis also showed good classification. To our knowledge, this is the first study to attempt to identify subgroup of persons with ASD who show specific treatment responsiveness using selected phenotype variables. We applied machine learning methods to further investigate these variables' ability to identify this subgroup of ASD, even when only a small sample size was available.
260. The Great East Japan Earthquake and hypertensive disorders of pregnancy: The TMM BirThree Cohort Study

Taku Obara, Takuma Usuzaki, Chizuru Yamanaka, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Masahiro Kikuya, Hirohito Metoki, Shinichi Kuriyama

Pregnancy Hypertension　13　S112-S113　2018年10月1日
出版者・発行元： Elsevier BV
DOI： 10.1016/j.preghy.2018.08.332 　

ISSN：2210-7789

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Introduction We experienced a devastating disaster, the Great East Japan Earthquake, in 2011. Some previous studies showed that disasters affected maternal blood pressure and their health. Its longer effect on pregnant women is necessary to investigate. Objective The purpose of this present study was to investigate if maternal disaster exposure affected their blood pressure. Methods The relationship between disaster exposure and maternal outcomes was retrospectively analyzed using the data of 4426 women who were recruited to the Tohoku Medical Megabank Birth and Three-generation Cohort Study, which was conducted in the years 2013–2017. Women were classified into three groups by the severity of the destruction of their house: group A, no destruction/did not live in the disaster-hit area; group B, half/a part of the house was destroyed; and group C, house totally/mostly destroyed. Multiple logistic regression analysis was performed to investigate the relationship between disaster exposure and hypertensive disorders of pregnancy, adjusting for body mass index, age, smoking, drinking, income, parity, and multiple pregnancy. Results Of 4,426 women eligible for the analyses, the houses of 489 women (11.0%) were totally or mostly destroyed, and the houses of 1706 women (38.5%) were half or partly destroyed. Those whose houses were not destroyed or did not live in the area affected by the disaster included 2,231 women (50.4%). The prevalence of hypertensive disorders of pregnancy in groups B and C were 0.82 and 1.47 times higher than in group A, but there was no statistical significance. Discussion Involvement in a disaster event about three to six years before pregnancy was not related to a higher prevalence of hypertensive disorders of pregnancy.
院内副作用事例の一元管理方法の構築電子カルテシステムのeXChart機能の活用査読有り

菊池大輔, 小原拓, 三浦良祐, 渡辺善照

医薬品相互作用研究　42　(3)　192-197　2018年10月
出版者・発行元：医薬品相互作用研究会
ISSN：0385-5015
Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. 査読有り

Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama

The Tohoku journal of experimental medicine　246　(2)　97-105　2018年10月

DOI： 10.1620/tjem.246.97 　

ISSN：0040-8727

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Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings. To obtain informed consent, we were careful of explaining clearly the complex reasons as well as drawing people's attention. By the end of March 2017, the number of invitation letters distributed to family members through the pregnant women was 23,806, including 18,702 grandparents. Among the grandparents who received invitation letters, 2,935 (15.7%) responded to us. Furthermore, some grandparents were asked to provide informed consent with other family members by staff at maternal clinics or Community Support Centers, and others directly booked Community Support Centers without responding to the invitation letter. Grandparents joined the study anytime during mother's maternal check-ups or delivery. Overall, 8,054 grandparents participated in our birth cohort study. The setting in which most grandparents were recruited was our own facilities. Importantly, both paternal and maternal grandparents more frequently participated in the study if the father also participated. In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents.
Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. 国際誌査読有り

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

Allergology international : official journal of the Japanese Society of Allergology　67　(4)　481-486　2018年10月

DOI： 10.1016/j.alit.2018.02.009 　

ISSN：1323-8930

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BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire. Clinical ranges of Strengths and Difficulties Questionnaire (SDQ) total difficulties scores and four SDQ subcategories of emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems were defined as scores ≥16, ≥5, ≥5, ≥7, and ≥5, respectively. RESULTS: The mean SDQ total difficulties score significantly increased as eczema status worsened (all P ≤ 0.004 for trend). The OR of scores in the clinical range for SDQ total difficulties were 1.51 (95% CI, 1.31-1.74) for mild/moderate eczema and 2.63 (95% CI, 1.91-3.63) for severe eczema (P < 0.001 for trend), adjusted for sex, school grade, current wheeze, and disaster-related factors, using normal eczema as a reference. The association between severity of eczema and four SDQ subcategories showed a similar trend (all P ≤ 0.017 for trend). CONCLUSIONS: We found a significant association between severity of eczema and mental health problems. The presence of eczema was associated with four SDQ subcategories.
Predictive power of home blood pressure indices at baseline and during follow-up in hypertensive patients: HOMED-BP study. 国際誌査読有り

Daisuke Watabe, Kei Asayama, Tomohiro Hanazawa, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo

Hypertension research : official journal of the Japanese Society of Hypertension　41　(8)　622-628　2018年8月

DOI： 10.1038/s41440-018-0050-4 　

ISSN：0916-9636

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We compared the predictive power for a major adverse cardiovascular event (MACE) of four home blood pressure (BP) indices (systolic BP, diastolic BP, mean BP, and pulse pressure (PP)) obtained at baseline before treatment and during the on-treatment follow-up period in 3147 patients with essential hypertension (women: 50.1%, mean age: 59.5 years). Associations between MACE and each index were determined using Cox proportional hazard models and the likelihood ratio (LR) test. During a median follow-up of 5.4 years, 46 patients experienced MACE, which was a composite of cardiovascular death, non-fatal stroke, and non-fatal myocardial infarction. The LR test showed that systolic, diastolic, and mean BP during follow-up was more closely associated with cardiovascular risk than the corresponding indices at baseline (LR χ2 for baseline versus follow-up: systolic BP, (6.0, P = 0.014) versus (11.3, P = 0.0008); diastolic BP, (0.4, P = 0.53) versus (12.4, P = 0.0004); mean BP, (3.2, P = 0.074) versus (15.0, P = 0.0001)), whereas neither PP at baseline nor that during follow-up was significantly associated with MACE risk. Among home BP indices during follow-up, mean BP further improved prediction models in which systolic or diastolic BP was already included (P ≤ 0.042), but neither systolic nor diastolic BP improved models with mean BP (P = 0.80). In addition to home systolic and diastolic BP, mean BP during follow-up period provides essential information in predicting future cardiovascular diseases, whereas its utilization should be further assessed by an intervention trial targeting mean BP levels.
N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years - The Ohasama Study. 査読有り

Michihiro Satoh, Takahisa Murakami, Kei Asayama, Takuo Hirose, Masahiro Kikuya, Ryusuke Inoue, Megumi Tsubota-Utsugi, Keiko Murakami, Ayako Matsuda, Azusa Hara, Taku Obara, Ryo Kawasaki, Kyoko Nomura, Hirohito Metoki, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

Circulation journal : official journal of the Japanese Circulation Society　82　(8)　2055-2062　2018年7月25日

DOI： 10.1253/circj.CJ-17-1227 　

ISSN：1346-9843

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BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been used for risk stratification in heart failure or acute coronary syndrome, but the beyond 5-year predictive value of NT-proBNP for stroke remains an unsettled issue in Asian patients. The aim of the present study was to clarify this point.Methods and Results:We followed 1,198 participants (33.4% men; mean age, 60.5±11.1 years old) in the Japanese general population for a median of 13.0 years. A first stroke occurred in 93 participants. Referencing previous reports, we stratified participants according to NT-proBNP 30.0, 55.0, and 125.0 pg/mL. Using the NT-proBNP <30.0 pg/mL group as a reference, adjusted HR for stroke (95% CI) in the NT-proBNP 30.0-54.9-pg/mL, 55.0-124.9-pg/mL, and ≥125.0-pg/mL groups were 1.92 (0.94-3.94), 1.77 (0.85-3.66), and 1.99 (0.86-4.61), respectively. With the maximum follow-up period set at 5 years, the hazard ratio of the NT-proBNP≥125.0-pg/mL group compared with the <30.0-pg/mL group increased significantly (HR, 4.51; 95% CI: 1.03-19.85). On extension of the maximum follow-up period, however, the association between NT-proBNP and stroke risk weakened. CONCLUSIONS: NT-proBNP was significantly associated with an elevated stroke risk. Given, however, that the predictive power decreased with the number of years after NT-proBNP measurement, NT-proBNP should be re-evaluated periodically in Asian patients.
Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients 査読有り

Miki Hosaka, Ryusuke Inoue, Michihiro Satoh, Daisuke Watabe, Tomohiro Hanazawa, Takayoshi Ohkubo, Kei Asayama, Taku Obara, Yutaka Imai, on behalf of The J-HOME-ALB Study group

Clinical and Experimental Hypertension　40　(5)　468-475　2018年7月4日
出版者・発行元： Taylor and Francis Ltd
DOI： 10.1080/10641963.2017.1403617 　

ISSN：1525-6006 1064-1963
Development of algorithms to determine the onset of pregnancy and delivery date using health care administrative data in a university hospital in Japan. 国際誌査読有り

Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Keiko Miyakoda, Ryusuke Inoue, Tetsuro Hoshiai, Masatoshi Saito, Nobuo Yaegashi, Nariyasu Mano

Pharmacoepidemiology and drug safety　27　(7)　751-762　2018年7月

DOI： 10.1002/pds.4444 　

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PURPOSE: To develop and assess algorithms to determine the onset of pregnancy and delivery date using health administrative data from a university hospital in Japan. METHODS: All women who were hospitalized in the maternity ward and had at least one pregnancy that ended with a delivery during the period of January 2014 and December 2015 were included in this study. The true delivery date was obtained from the electronic medical records and was used as a gold standard. The onset of pregnancy was calculated by subtracting the gestational age at birth from the delivery date based on the electronic medical records and was also used as a gold standard. The administrative data-based algorithms to identify (1) the onset of pregnancy estimated from the gestational age recorded as part of a diagnosis during a specific visit and (2) the delivery date estimated using the delivery-related diagnosis, procedure, or prescription were compared with the gold-standard data. RESULTS: Of the 1705 women included in this study, the onset of pregnancy was determined in 1704 subjects with 1582 (92.8%) within ± 7 days from the gold-standard date of pregnancy onset. The delivery date was determined in 1654 subjects, and 1594 (96.4%) were within ± 7 days before the true delivery date using the algorithm of "selected" diagnosis and a surgical procedure followed by some other delivery-related data. CONCLUSIONS: The algorithms developed in this study are expected to accelerate future studies for real-world exposure and quantify drug safety during pregnancy using Japanese health care administrative databases.
医薬品安全性情報報告の基準と手順を考える医薬品・医療機器等安全性情報報告制度を活用するために

小原拓, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　21回　66-66　2018年6月
出版者・発行元： (一社)日本医薬品情報学会
添付文書および医薬品インタビューフォームにおける血液透析患者への投与方法に関する記載内容調査

八島一史, 小原拓, 中川直人, 中曽根正皓, 大柳元, 荒木勇太, 細谷絵美, 前川麻央, 前嶋隆弘, 高橋阿希子, 木皿重樹, 眞野成康

医薬品相互作用研究　42　(2)　111-115　2018年6月
出版者・発行元：医薬品相互作用研究会
ISSN：0385-5015
医薬品情報データベースを活用したこれからの薬剤師業務〜Web上のオープンデータをどう活かすか〜医薬品副作用データベースを薬剤師業務に生かすには JADERを例に査読有り

土屋雅美, 小原拓, 眞野成康, 高村千津子

日本医薬品情報学会総会・学術大会講演要旨集　21回　64-64　2018年6月
出版者・発行元： (一社)日本医薬品情報学会
Defined Daily Doseと比較した日本の降圧薬処方用量レセプトデータに基づく検討査読有り

佐藤倫広, 村上任尚, 小原拓, 辰巳友佳子, 高畠恭介, 原梓, 浅山敬, 今井潤, 大久保孝義, 目時弘仁

日本医薬品情報学会総会・学術大会講演要旨集　21回　125-125　2018年6月
出版者・発行元： (一社)日本医薬品情報学会
Association Between Amplitude of Seasonal Variation in Self-Measured Home Blood Pressure and Cardiovascular Outcomes: HOMED-BP (Hypertension Objective Treatment Based on Measurement By Electrical Devices of Blood Pressure) Study. 国際誌査読有り

Tomohiro Hanazawa, Kei Asayama, Daisuke Watabe, Ayumi Tanabe, Michihiro Satoh, Ryusuke Inoue, Azusa Hara, Taku Obara, Masahiro Kikuya, Kyoko Nomura, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo

Journal of the American Heart Association　7　(10)　2018年5月4日

DOI： 10.1161/JAHA.117.008509 　

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BACKGROUND: The clinical significance of long-term seasonal variations in self-measured home blood pressure (BP) has not been elucidated for the cardiovascular disease prevention. METHODS AND RESULTS: Eligible 2787 patients were classified into 4 groups according to the magnitude of their seasonal variation in home BP, defined as an average of all increases in home BP from summer (July-August) to winter (January-February) combined with all decreases from winter to summer throughout the follow-up period, namely inverse- (systolic/diastolic, <0/<0 mm Hg), small- (0-4.8/0-2.4 mm Hg), middle- (4.8-9.1/2.4-4.5 mm Hg), or large- (≥9.1/≥4.5 mm Hg) variation groups. The overall cardiovascular risks illustrated U-shaped relationships across the groups, and hazard ratios for all cardiovascular outcomes compared with the small-variation group were 3.07 (P=0.004) and 2.02 (P=0.041) in the inverse-variation group and large-variation group, respectively, based on systolic BP, and results were confirmatory for major adverse cardiovascular events. Furthermore, when the summer-winter home BP difference was evaluated among patients who experienced titration and tapering of antihypertensive drugs depending on the season, the difference was significantly smaller in the early (September-November) than in the late (December-February) titration group (3.9/1.2 mm Hg versus 7.3/3.1 mm Hg, P<0.001) as well as in the early (March-May) than in the late (June-August) tapering group (4.4/2.1 mm Hg versus 7.1/3.4 mm Hg, P<0.001). CONCLUSIONS: The small-to-middle seasonal variation in home BP (0-9.1/0-4.5 mm Hg), which may be partially attributed to earlier adjustment of antihypertensive medication, were associated with better cardiovascular outcomes.
Prevalence of Therapeutic Drug Monitoring for Lithium and the Impact of Regulatory Warnings: Analysis Using Japanese Claims Database. 国際誌

Nobuhiro Ooba, Daisuke Tsutsumi, Naoko Kobayashi, Shinji Hidaka, Hiroyuki Hayashi, Taku Obara, Michihiro Satoh, Kiyoshi Kubota, Noriyasu Fukuoka

Therapeutic drug monitoring　40　(2)　252-256　2018年4月

DOI： 10.1097/FTD.0000000000000483 　

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BACKGROUND: Therapeutic drug monitoring (TDM) for lithium is recommended in guidelines; however, the prevalence of TDM for lithium is seldom reported. We have therefore investigated the prevalence of TDM for lithium and evaluated the impact of the regulatory warnings requiring routine TDM for lithium. METHODS: Monthly claims data covering around 1.7 million persons aged 20-74 years old during the period January 1, 2005, and March 31, 2015, were evaluated. All patients who had at least one prescription for lithium were selected and included to calculate the annual prevalence of TDM for lithium. Also we assessed whether the 2 regulatory warnings requiring routine TDM for lithium and issued in April 2012 and September 2012 had an impact on TDM for lithium, using segmented regression analysis. RESULTS: Between 2005 and 2014, 136,956 prescriptions of lithium were issued to 5823 patients, and the annual prevalence of TDM for lithium was 14.9% (95% confidence interval, 14.7%-15.1%). The analysis revealed that the mean prevalence increased abruptly by 6.9% (P = 0.001) after the regulatory warning in April 2012, whereas that the warning in September 2012 decreased by 1.2% (P = 0.47). There was no significant change in trends of period prevalence after the warning in April 2012 (April 2012-August 2012) compared with prevalence before the warning (April 2010-March 2012). Similarly, no significant change was observed in the trends before (April 2012-August 2012) and after (September 2012-March 2014) the subsequent warning in September 2012. CONCLUSIONS: Results showed that the prevalence of TDM for lithium was low, although TDM for lithium was strongly recommended by the guidelines. Regulatory warnings requiring compliance with the measurement of blood levels during treatment with lithium, issued twice during the five-month period, were associated with an increase in the prevalence of TDM for lithium. However, the impact of the second warning was not remarkable compared with the first warning.
Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: The Kakegawa cohort study. 国際誌査読有り

Hisashi Ohseto, Mami Ishikuro, Masahiro Kikuya, Taku Obara, Yuko Igarashi, Satomi Takahashi, Daisuke Kikuchi, Michiko Shigihara, Chizuru Yamanaka, Masako Miyashita, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Yuki Sato, Hirohito Metoki, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

Journal of psychosomatic research　107　20-25　2018年4月

DOI： 10.1016/j.jpsychores.2018.01.013 　

ISSN：0022-3999

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OBJECTIVE: Metabolic syndrome and the presence of metabolic syndrome components are risk factors for cardiovascular disease (CVD). However, the association between personality traits and metabolic syndrome remains controversial, and few studies have been conducted in East Asian populations. METHODS: We measured personality traits using the Japanese version of the Eysenck Personality Questionnaire (Revised Short Form) and five metabolic syndrome components-elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose-in 1322 participants aged 51.1±12.7years old from Kakegawa city, Japan. Metabolic syndrome score (MS score) was defined as the number of metabolic syndrome components present, and metabolic syndrome as having the MS score of 3 or higher. We performed multiple logistic regression analyses to examine the relationship between personality traits and metabolic syndrome components and multiple regression analyses to examine the relationship between personality traits and MS scores adjusted for age, sex, education, income, smoking status, alcohol use, and family history of CVD and diabetes mellitus. We also examine the relationship between personality traits and metabolic syndrome presence by multiple logistic regression analyses. RESULTS: "Extraversion" scores were higher in those with metabolic syndrome components (elevated waist circumference: P=0.001; elevated triglycerides: P=0.01; elevated blood pressure: P=0.004; elevated fasting glucose: P=0.002). "Extraversion" was associated with the MS score (coefficient=0.12, P=0.0003). No personality trait was significantly associated with the presence of metabolic syndrome. CONCLUSIONS: Higher "extraversion" scores were related to higher MS scores, but no personality trait was significantly associated with the presence of metabolic syndrome.
レセプトデータを利用した小児ADHD患者における処方実態の把握

吉田真貴子, 小原拓, 菊地紗耶, 菊地正史, 山口浩明, 眞野成康

日本薬学会年会要旨集　138年会　(4)　185-185　2018年3月
出版者・発行元： (公社)日本薬学会
ISSN：0918-9823
周辺施設へのアクセシビリティと産後うつとの関連三世代コホート調査査読有り

永井雅人, 水野聖士, 石黒真美, 宮下真子, 山中千鶴, 佐藤ゆき, 松原博子, 小原拓, 菊谷昌浩, 目時弘仁, 栗山進一

宮城県公衆衛生学会会誌　(50)　30-30　2018年3月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
医薬品情報の薬薬連携を指向した病院ならびに薬局対象のアンケート調査と研修会開催の成果平成28年度課題研究班成果報告査読有り

橋本貴尚, 菊池大輔, 新沼佑美, 小原拓, 村井ユリ子, 畑中貞雄, 栃窪克行, 渡辺善照

医薬品情報学　19　(4)　158-171　2018年2月
出版者・発行元： (一社)日本医薬品情報学会
ISSN：1345-1464

eISSN：1883-423X
日本および米国における薬剤師の臨床試験の論文利用に関する比較調査—宮城県およびフロリダ州におけるアンケート調査— 査読有り

中川直人, 村井ユリ子, 小原拓, 大原宏司, 栗田幸代, Lai Leanne

医薬品情報学　19　(4)　180-187　2018年
出版者・発行元：一般社団法人日本医薬品情報学会
DOI： 10.11256/jjdi.19.180 　

ISSN：1345-1464

eISSN：1883-423X
レセプトデータベースに基づく妊娠前，妊娠中，および出産後の抗てんかん薬処方状況の評価査読有り

石川智史, 栗山進一, 眞野成康, 小原拓, 神一敬, 西郡秀和, 都田桂子, 鈴鹿雅人, 赤沢学, 中里信和, 八重樫伸生

薬剤疫学　23　(0)　s98-s98　2018年
出版者・発行元：一般社団法人日本薬剤疫学会
DOI： 10.3820/jjpe.23.s98 　

ISSN：1342-0445
Genome-wide association study for white coat effect in Japanese middle-aged to elderly people: The HOMED-BP study. 国際誌査読有り

Soshiro Ogata, Kei Kamide, Kei Asayama, Yasuharu Tabara, Takahisa Kawaguchi, Michihiro Satoh, Tomohiro Katsuya, Ken Sugimoto, Takuo Hirose, Ryusuke Inoue, Azusa Hara, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Fumihiko Matsuda, Jan A Staessen, Takayoshi Ohkubo, Hiromi Rakugi, Yutaka Imai

Clinical and experimental hypertension (New York, N.Y. : 1993)　40　(4)　363-369　2018年

DOI： 10.1080/10641963.2017.1384481 　

ISSN：1064-1963

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BACKGROUND: White coat effect (WCE), the blood pressure (BP) difference between clinical and non-clinical settings, can lead to clinical problems such as misdiagnosis of hypertension. Etiology of WCE has been still unclear, especially from genetic aspects. The present article investigated association between genome-wide single nucleotide polymorphisms (SNPs) and WCE in patients with essential hypertension. METHODS: The present cross-sectional analyses were based on 295 Japanese essential hypertensive outpatients aged ≧40 years enrolled in randomized control study, Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study, who were not taking antihypertensive medications before the randomization. Home and clinic BP were measured. WCE was defined by subtracting home BP from clinic BP. Genotyping was conducted with 500K DNA microarray chips. Association between genome-wide SNPs and WCE were analyzed. For replication (p < 10-4), we analyzed participants from Ohasama study who took no antihypertension medications and whose SNPs were collected. RESULTS: Genome-wide SNPs were not significantly associated with WCE of systolic and diastolic BP after corrections of multiple comparisons (p < 2 × 10-7). We found suggestive SNPs associated with WCE of systolic and diastolic BP (p < 10-4). However, the consistent results were not obtained in the replication study. CONCLUSION: The present article showed no significant association between genome-wide SNPs and WCE. Since there were several suggestive SNPs associated with WCE, the present study warrants a further study with bigger sample size for investigating the genetic influence on WCE.
Nocturnal blood pressure decline based on different time intervals and long-term cardiovascular risk: the Ohasama Study. 国際誌査読有り

Michihiro Satoh, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Megumi Tsubota-Utsugi, Taku Obara, Keiko Murakami, Ayako Matsuda, Takahisa Murakami, Kyoko Nomura, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo

Clinical and experimental hypertension (New York, N.Y. : 1993)　40　(1)　1-7　2018年

DOI： 10.1080/10641963.2016.1259324 　

ISSN：1064-1963

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A diminished nocturnal decline in blood pressure (BP) represents a risk factor for cardiovascular disease. To define daytime and nighttime ambulatory BP, clock time-dependent methods are used when information on diary-based sleeping time is unavailable. We aimed to compare fixed-clock intervals with diary records to identify nocturnal BP declines as a predictor of long-term cardiovascular risk among the general population. Data were obtained from 1714 participants with no history of cardiovascular disease in Ohasama, Japan (mean age, 60.6 years; 64.9% women). We defined extreme dippers, dippers, non-dippers, and risers as nocturnal systolic BP decline ≥20%, 10-19%. 0-9%, and <0%, respectively. Over a mean follow-up period of 17.0 years, 206 cardiovascular deaths occurred. Based on diary records, multivariable-adjusted hazard ratios (HRs) for cardiovascular death compared with dippers were 1.24 (95% confidence interval [CI], 0.82-1.87) in extreme dippers, 1.21 (0.87-1.69) in non-dippers, and the highest HR of 2.31 (1.47-3.62) was observed in risers. Using a standard fixed-clock interval (daytime 09:00-21:00; nighttime 01:00-06:00), a nighttime 2 h-early shifted fixed-clock (daytime 09:00-21:00; nighttime 23:00-04:00), or a nighttime 2 h-late shifted fixed-clock (daytime 09:00-21:00; nighttime 03:00-08:00), the HR (95%CI) in risers compared with dippers was 1.57 (1.08-2.27), 2.02 (1.33-3.05), or 1.29 (0.86-1.92), respectively. Although use of diary records remains preferable, the standard and nighttime 2 h-early shifted fixed-clock intervals appear feasible for population-based studies.
Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis 査読有り

Hiroshi Hidaka, Daiki Ozawa, Shinichi Kuriyama, Taku Obara, Toru Nakano, Risako Kakuta, Kazuhiro Nomura, Kenichi Watanabe, Yukio Katori

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(11)　3951-3958　2017年11月

DOI： 10.1007/s00405-017-4716-3 　

ISSN：0937-4477

eISSN：1434-4726
Exploring Risk Factors of Patient Falls: A Retrospective Hospital Record Study in Japan 査読有り

Mami Ishikuro, Sergio Ramon Gutierrez Ubeda, Taku Obara, Toshihide Saga, Naofumi Tanaka, Chiyo Oikawa, Keisei Fujimori

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　243　(3)　195-203　2017年11月

DOI： 10.1620/tjem.243.195 　

ISSN：0040-8727

eISSN：1349-3329
家庭血圧および家庭脈拍とそれらの日間変動の加齢に伴う推移大迫研究査読有り

佐藤倫広, 浅山敬, 菊谷昌浩, 井上隆輔, 小原拓, 村上慶子, 村上任尚, 原梓, 川崎良, 野村恭子, 目時弘仁, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　40回　409-409　2017年10月
出版者・発行元： (NPO)日本高血圧学会
降圧治療中患者におけるHome Arterial Stiffness Index(HASI)の臨床的有用性の評価査読有り

小原拓, 菊谷昌浩, 佐藤倫広, 井上隆輔, 浅山敬, 目時弘仁, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　40回　446-446　2017年10月
出版者・発行元： (NPO)日本高血圧学会
Alterations in physique among young children after the Great East Japan Earthquake: Results from a nationwide survey 査読有り

Masahiro Kikuya, Hiroko Matsubara, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Shigeo Kure, Shinichi Kuriyama

JOURNAL OF EPIDEMIOLOGY　27　(10)　462-468　2017年10月

DOI： 10.1016/j.je.2016.09.012 　

ISSN：0917-5040
一般地域住民における家庭血圧に基づく高血圧の分布大迫研究査読有り

佐藤倫広, 村上任尚, 浅山敬, 菊谷昌浩, 井上隆輔, 坪田恵, 小原拓, 村上慶子, 松田彩子, 原梓, 野村恭子, 目時弘仁, 今井潤, 大久保孝義

東北公衆衛生学会誌　(66)　40-40　2017年7月
出版者・発行元：東北公衆衛生学会
ISSN：0915-549X
Pregnant Women's Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children's Study 査読有り

Hidekazu Nishigori, Toshie Nishigori, Kasumi Sakurai, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Zen Watanabe, Noriyuki Iwama, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Shinichi Kuriyama, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Fumiaki Takahashi, Nobuo Yaegashi

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(3)　355-364　2017年6月

DOI： 10.1017/dmp.2016.150 　

ISSN：1935-7893

eISSN：1938-744X
Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study 査読有り

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Satoshi Mizuno, Hirohito Metoki, Tetsuro Hoshiai, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

CONGENITAL ANOMALIES　57　(3)　72-78　2017年5月

DOI： 10.1111/cga.12202 　

ISSN：0914-3505

eISSN：1741-4520
Drug Use before and during Pregnancy in Japan: The Japan Environment and Children's Study. 国際誌査読有り

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Satoshi Mizuno, Kasumi Sakurai, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Shinichi Kuriyama, Nobuo Yaegashi

Pharmacy (Basel, Switzerland)　5　(2)　2017年4月10日

DOI： 10.3390/pharmacy5020021 　

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Purpose: To elucidate drug use before and during pregnancy in Japan. Methods: The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study. We analyzed data from JECS involving cases where drugs were used for 12 months before pregnancy was diagnosed, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy. Results: We analyzed data from 97,464 pregnant women. The percentages of pregnant women who had taken one or more drugs and supplements before diagnosis of pregnancy, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy, were 78.4%, 57.1%, and 68.8% respectively. Excluding iron supplements, folic acid, and other vitamins and minerals, the percentages of women taking supplements were 75.3%, 36.0%, and 51.7% at each respective time point. The following drugs and supplements were frequently used for 12 months before pregnancy diagnosis: Commercially available antipyretics, analgesics, and/or medicine for treating common cold (34.7%), antipyretics, analgesics, and/or medicine for treating common colds, which were prescribed in hospitals (29.8%), antimicrobial drugs (14.0%), and anti-allergy drugs (12.5%). The following drugs and supplements were frequently used from the time of pregnancy diagnosis until week 12 of pregnancy, and after week 12 of pregnancy: folic acid (28.9% and 26.2%), antipyretics, analgesics and/or medicines for treating common cold, that were prescribed in hospitals (7.8% and 13.3%), Chinese herbal medicines (6.0% and 9.4%, and uterine relaxants (5.1% and 15.2%). Conclusions: The analysis of a nationwide cohort study showed that a high percentage of Japanese pregnant women were taking medicinal drugs. Further research is required to elucidate the relationship between drug use during pregnancy and birth defects in Japan.
Incidence of Domestic Violence Against Pregnant Females After the Great East Japan Earthquake in Miyagi Prefecture: The Japan Environment and Children's Study 査読有り

Kasumi Sakurai, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Fumiaki Takahashi, Kunihiko Nakai, Nobuo Yaegashi

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(2)　216-226　2017年4月

DOI： 10.1017/dmp.2016.109 　

ISSN：1935-7893

eISSN：1938-744X
東日本大震災後の保育所園児における過体重の発症被災地の子どもの発育状況等に関する全国調査査読有り

菊谷昌浩, 松原博子, 石黒真美, 佐藤ゆき, 小原拓, 目時弘仁, 磯島豪, 横谷進, 加藤則子, 田中敏章, 千田勝一, 小野敦史, 細矢光亮, 横道洋司, 山縣然太朗, 田中総一郎, 呉繁夫, 栗山進一

宮城県公衆衛生学会会誌　(49)　15-15　2017年3月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
Seasonal variation in self-measured home blood pressure among patients on antihypertensive medications: HOMED-BP study 査読有り

Tomohiro Hanazawa, Kei Asayama, Daisuke Watabe, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo

HYPERTENSION RESEARCH　40　(3)　284-290　2017年3月

DOI： 10.1038/hr.2016.133 　

ISSN：0916-9636

eISSN：1348-4214
Prevalence and determinants of inadequate use of folic acid supplementation in Japanese pregnant women: the Japan Environment and Children's Study (JECS) 査読有り

Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE　30　(5)　588-593　2017年3月

DOI： 10.1080/14767058.2016.1179273 　

ISSN：1476-7058

eISSN：1476-4954
Disease prevalence among nursery school children after the Great East Japan earthquake. 国際誌査読有り

Mami Ishikuro, Hiroko Matsubara, Masahiro Kikuya, Taku Obara, Yuki Sato, Hirohito Metoki, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Shigeo Kure, Shinichi Kuriyama

BMJ global health　2　(2)　e000127　2017年

DOI： 10.1136/bmjgh-2016-000127 　

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OBJECTIVE: To investigate the relationship between personal experience of the Great East Japan Earthquake and various disease types among nursery school children. DESIGN: We conducted a nationwide survey of nursery school children born between 2 April 2006 and 1 April 2007. Nursery school teachers completed questionnaires if they agreed to join the study. Questionnaire items for children consisted of their birth year and month, sex, any history of moving into or out of the current nursery school, presence of diseases diagnosed by a physician at the age of 66-78 months and type of disaster experience. The survey was conducted from September 2012 to December 2012. SETTING: Japan, nationwide. PARTICIPANTS: A total of 60 270 nursery school children were included in the analysis, 840 of whom experienced the disaster on 11 March 2011. MAIN OUTCOME MEASURES: The health status of children 1.5 years after the disaster based on nursery school records. RESULTS: Experiencing the disaster significantly affected the prevalence of overall and individual diseases. Furthermore, there was a difference in disease prevalence between boys and girls. In boys, experiencing the tsunami (OR 2.53, 95% CI 1.22 to 5.24) and living in an evacuation centre (OR 2.92, 95% CI 1.46 to 5.83) were remarkably associated with a higher prevalence of atopic dermatitis, but these trends were not observed among girls. Instead, the home being destroyed (OR 3.50, 95% CI 2.02 to 6.07) and moving house (OR 4.19, 95% CI 2.01 to 8.71) were positively associated with a higher prevalence of asthma among girls. CONCLUSIONS: Our study indicates that experiencing the disaster may have affected the health status of nursery school children at least up to 1.5 years after the disaster. Continuous monitoring of the health status of children is necessary to develop strategic plans for child health.
Randomized controlled trial of the effects of consumption of 'Yabukita' or 'Benifuuki' encapsulated tea-powder on low-density lipoprotein cholesterol level and body weight. 国際誌査読有り

Yuko Igarashi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Michiko Shigihara, Hirohito Metoki, Masahiro Kikuya, Yoichi Sameshima, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

Food & nutrition research　61　(1)　1334484-1334484　2017年

DOI： 10.1080/16546628.2017.1334484 　

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Background: Previous studies have reported controversial results for the association between green tea consumption and low-density lipoprotein (LDL)-cholesterol and body weight. Objective: The objective of this trial was to determine the effects of two kinds of green tea on LDL-cholesterol and body weight. Methods: We randomly assigned 151 participants (98 men, 53 women) aged 30-70 years into three groups: Yabukita green tea group, Benifuuki green tea group, or placebo group. Participants consumed 1.8 g/day of green tea extract powder or placebo for 12 weeks. The primary outcomes were LDL-cholesterol level and body weight, and the secondary outcomes were risk factors for cardiovascular disease. Results: Both Yabukita and Benifuuki green tea significantly lowered LDL-cholesterol. The magnitudes of the lipid-lowering effect of both types of tea were significantly larger than that of placebo. No differences with respect to changes in LDL-cholesterol were observed between the Yabukita and Benifuuki green tea groups. Neither Yabukita nor Benifuuki green tea had any effect on body weight and no difference was observed among groups regarding changes in body weight. Conclusion: Both Yabukita and Benifuuki green tea lowered LDL-cholesterol, and the lipid-lowering effects of these two green teas were not different. Neither tea lowered body weight.
病院レセプトデータを用いた降圧薬の処方動向に関する調査

佐藤倫広, 黒澤桂子, 小原拓, 松浦正樹, 井上隆輔, 高橋信行, 佐藤博, 村井ユリ子, 眞野成康

医療薬学　43　(1)　9-17　2017年
出版者・発行元：一般社団法人日本医療薬学会
ISSN：1346-342X

eISSN：1882-1499
Fermented food consumption and psychological distress in pregnant women: A nationwide birth cohort study of the Japan environment and children’s study 査読有り

Fumiaki Takahashi, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Mami Ishikuro, Noriyuki Iwama, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi, Hirohisa Saito, Reiko Kishi, Koichi Hashimoto, Chisato Mori, Fumiki Hirahara, Zentaro Yamagata, Hidekuni Inadera, Michihiro Kamijima, Ikuo Konishi, Hiroyasu Iso, Masayuki Shima, Toshihide Ogawa, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh

Tohoku Journal of Experimental Medicine　240　(4)　309-321　2016年12月1日

DOI： 10.1620/tjem.240.309 　

ISSN：0040-8727

eISSN：1349-3329
Prescription trends in children with pervasive developmental disorders: a claims data-based study in Japan. 国際誌査読有り

Michihiro Satoh, Taku Obara, Hidekazu Nishigori, Nobuhiro Ooba, Yoshihiko Morikawa, Mami Ishikuro, Hirohito Metoki, Masahiro Kikuya, Nariyasu Mano

World journal of pediatrics : WJP　12　(4)　443-449　2016年11月

DOI： 10.1007/s12519-016-0036-8 　

ISSN：1708-8569

eISSN：1867-0687

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BACKGROUND: The only drug approved for pervasive developmental disorders (PDD) in Japan is pimozide. Several psychotropic drugs are also prescribed for offlabel use in Japan, but details regarding their prescription and use are largely unknown. The purpose of this study was to clarify the use of drug treatment in Japanese children with PDD. METHODS: Data were extracted from claims data from the Japan Medical Data Center for children younger than 18 years of age who were newly diagnosed with PDD (International Classification of Diseases version 10 codes: F84) from 2005 to 2010 (total of 3276 patients as of 2010). The prescription rates were presented as the percentage of PDD patients who were prescribed each drug. RESULTS: Prior to 2010, the prescription rates for atypical antipsychotics, other antipsychotics, psychostimulants, all other central nervous system drugs, anticovnvulsants, non-barbiturates, and Parkinson's disease/syndrome drugs significantly increased among the Anatomical Therapeutic Chemical classifications defined as the "nervous system" (trend P≤0.02). The prescription rate for risperidone consistently increased, reaching 6.9% in 2010 (trend P<0.0001), the highest rate of the surveyed drugs among the antipsychotics. The prescription rate for aripiprazole also increased (trend P<0.0001), reaching 1.9% in 2010. The prescription rate for pimozide showed no annual changes, with a low rate of 0.4% in 2010. CONCLUSION: Compared with pimozide, the prescription rates for risperidone, aripiprazole and other psychotropic drugs have increased. Because safety data for these drugs in Japanese children are sparse, there is a need for future safety evaluations of these drugs in Japanese children.
Present Condition of Fall Incidents in Tohoku University Hospital, Japan 査読有り

Harumi Memezawa, Chiyo Oikawa, Masao Tabata, Taku Obara, Keisei Fujimori

ISQua’s 33rd International Conference　2016年10月16日
Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study 査読有り

Satoshi Mizuno, Hidekazu Nishigori, Takashi Sugiyama, Fumiaki Takahashi, Noriyuki Iwama, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Kunihiko Nakai, Hidekuni Inadera, Nobuo Yaegashi

DIABETES RESEARCH AND CLINICAL PRACTICE　120　132-141　2016年10月

DOI： 10.1016/j.diabres.2016.07.020 　

ISSN：0168-8227

eISSN：1872-8227
出生児の神経管閉鎖障害リスク低下を目的とした葉酸摂取に関する地域の薬剤師の認識と推奨の割合と要因

浅野二未也, 小原拓, 佐藤倫広, 大原宏司, 山口浩明, 早坂正孝, 眞野成康, 村井ユリ子

医薬品相互作用研究　40　(1-2)　14-20　2016年9月
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
わが国の外来患者における家庭血圧測定の現状 10年の変遷

小原拓, 阿部真也, 吉町昌子, 佐藤倫広, 大久保孝義, 眞野成康, 後藤輝明, 今井潤

日本高血圧学会総会プログラム・抄録集　39回　426-426　2016年9月
出版者・発行元： (NPO)日本高血圧学会
一般地域住民における異なる時間定義に基づく夜間降圧度と脳心血管長期予後との関連大迫研究査読有り

佐藤倫広, 浅山敬, 菊谷昌浩, 井上隆輔, 坪田恵, 小原拓, 村上慶子, 松田彩子, 村上任尚, 野村恭子, 目時弘仁, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　39回　319-319　2016年9月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧の季節変動と脳心血管イベントとの関連 HOMED-BP研究査読有り

花澤智大, 浅山敬, 渡部大介, 田辺杏由美, 佐藤倫広, 井上隆輔, 小原拓, 菊谷昌浩, 野村恭子, 目時弘仁, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　39回　387-387　2016年9月
出版者・発行元： (NPO)日本高血圧学会
The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements 査読有り

Michihiro Satoh, Toshikazu Haga, Miki Hosaka, Taku Obara, Hirohito Metoki, Takahisa Murakami, Masahiro Kikuya, Ryusuke Inoue, Kei Asayama, Nariyasu Mano, Takayoshi Ohkubo, Yutaka Imai

JOURNAL OF HYPERTENSION　34　(6)　1218-1223　2016年6月

DOI： 10.1097/HJH.0000000000000902 　

ISSN：0263-6352

eISSN：1473-5598
Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area 査読有り

Mami Ishikuro, Naoki Nakaya, Taku Obara, Yuki Sato, Hirohito Metoki, Masahiro Kikuya, Naho Tsuchiya, Tomohiro Nakamura, Fuji Nagami, Shinichi Kuriyama, Atsushi Hozawa

PREHOSPITAL AND DISASTER MEDICINE　31　(3)　330-334　2016年6月

DOI： 10.1017/S1049023X16000182 　

ISSN：1049-023X

eISSN：1945-1938
Knowledge, Attitude, and Practices Toward Blood Pressure Measurement at Home Among Japanese Nurses. 国際誌査読有り

Ishikuro M, Ubeda SR, Obara T, Watanabe I, Metoki H, Kikuya M, Kuriyama S, Maruyama R, Ohkubo T, Imai Y

Home healthcare now　34　(4)　210-217　2016年4月

DOI： 10.1097/NHH.0000000000000357 　

ISSN：2374-4529
本邦の薬剤師におけるファーマコビジランスに関する認識と展望

小原拓, 吉田真貴子, 山口浩明, 赤坂和俊, 松浦正樹, 佐藤真由美, 村井ユリ子, 土屋文人, 北田光一, 眞野成康

日本薬学会年会要旨集　136年会　(4)　229-229　2016年3月
出版者・発行元： (公社)日本薬学会
ISSN：0918-9823
三世代コホート調査の進捗について査読有り

目時弘仁, 石黒真美, 小原拓, 佐藤ゆき, 菊谷昌浩, 栗山進一, 寳澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 冨永悌二, 布施昇男, 峯岸直子, 辻一郎, 呉繁夫, 八重樫伸生, 山本雅之

宮城県公衆衛生学会会誌　(48)　10-10　2016年3月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
Pregnant Women Had the Risk of Psychological Distress in Miyagi After the Great East Japan Earthquake: The Japan Environment and Children's Study (JECS). 査読有り

Zen Watanabe, Hirohito Metoki, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Nobuo Yaegashi

REPRODUCTIVE SCIENCES　23　186A-186A　2016年3月

ISSN：1933-7191

eISSN：1933-7205
Knowledge of and perspectives on pharmacovigilance among pharmacists in the Miyagi and Hokkaido regions of Japan 査読有り

Taku Obara, Hiroaki Yamaguchi, Yutaro Iida, Michihiro Satoh, Takamasa Sakai, Yoshiko Aoki, Yuriko Murai, Masaki Matsuura, Mayumi Sato, Takayoshi Ohkubo, Ken Iseki, Nariyasu

J Pharmacovigil　4　(1)　192　2016年2月

DOI： 10.4172/2329-6887.1000192 　
Home blood pressure level and decline in renal function among treated hypertensive patients: the J-HOME-Morning Study 査読有り

Kazuki Ishikura, Taku Obara, Masahiro Kikuya, Michihiro Satoh, Miki Hosaka, Hirohito Metoki, Hidekazu Nishigori, Nariyasu Mano, Masaaki Nakayama, Yutaka Imai, Takayoshi Ohkubo

HYPERTENSION RESEARCH　39　(2)　107-112　2016年2月

DOI： 10.1038/hr.2015.110 　

ISSN：0916-9636

eISSN：1348-4214
葉酸による出生児の神経管閉鎖障害リスク低下効果に関する看護学生の認識

小野木弘志, 小原拓, 浅野二未也, 佐藤倫広, 眞野成康, 佐藤喜根子, 村井ユリ子

日本補完代替医療学会誌　13　(1)　7-11　2016年
出版者・発行元：日本補完代替医療学会
DOI： 10.1625/jcam.13.7 　

ISSN：1348-7922

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目的：看護学生における周産期の葉酸摂取の重要性に関する認識を明らかにすること．方法：東北大学および東北福祉大学の看護学生423名に質問票調査を行った．結果：回答者408名(回答率；96.5%)のうち，31.6%が葉酸摂取が出生児の神経管閉鎖障害リスク低下効果を有することを認識していた．多変量解析の結果，1-2年生に比べ，3-4年生の方が葉酸摂取の重要性を認識していることが明らかとなった．葉酸摂取が出生児の神経管閉鎖障害リスク低下効果を有することを認識していた129名のうち，妊娠前から葉酸を摂取開始すべきであることを認識していたのは40.3%，妊娠中に葉酸を1日400μg摂取すべきであることを認識していたのは8.5%であった．結論：葉酸摂取が出生児の神経管閉鎖障害リスク低下効果を有することを認識していた看護学生は約30%であった．今後，看護学生に対してより積極的に葉酸摂取の重要性について教育する必要があると考えられた．
葉酸による出生児の神経管閉鎖障害リスク低下効果に関する薬学生の認識

高橋敦史, 小原拓, 大原宏司, 佐藤倫広, 浅野二未也, 小野木弘志, 早坂正孝, 佐藤博, 眞野成康, 村井ユリ子

医薬品情報学　17　(4)　185-191　2016年
出版者・発行元：一般社団法人日本医薬品情報学会
DOI： 10.11256/jjdi.17.185 　

ISSN：1345-1464

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Objective: Adequate periconceptional folic acid intake decreases the risk of neural tube defects in infants. The present study aimed to investigate the awareness of pharmacy students regarding the importance of folic acid intake for the prevention of neural tube defects.Design: Questionnaire survey.Methods: A self-administered questionnaire regarding the importance of folic acid intake for the prevention of neural tube defects was distributed to 750 pharmacy students at Tohoku and Ohu Universities.Results: Among the 685 respondents (response rate; 91.3%), 74 (10.8%) were aware that folic acid intake decreases the risk of neural tube defects. In multivariate logistic regression analysis, awareness of the importance of folic acid intake was evident among 5th- and 6th-year pharmacy students (odds ratio=3.352, 95% confidence interval=1.797-6.253) and among those who used dietary supplements (2.275, 1.306-3.966). Among the 74 pharmacy students who recognized the importance of folic acid intake, 17 (23.0%) and 3 (4.1%) were aware that women should begin taking a folic acid supplement before conception and should take about 400 μg per day during pregnancy, respectively.Conclusion: Only about 10% of the pharmacy students in this study recognized that folic acid intake decreases the risk of neural tube defects, and many were unaware of the recommended intake amount. Therefore, awareness of the importance of folic acid intake must be more aggressively promoted among pharmacy students.
Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements The Ohasama Study 査読有り

Michihiro Satoh, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Miki Hosaka, Megumi Tsubota-Utsugi, Taku Obara, Aya Ishiguro, Keiko Murakami, Ayako Matsuda, Daisaku Yasui, Takahisa Murakami, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

HYPERTENSION　67　(1)　48-55　2016年1月

DOI： 10.1161/HYPERTENSIONAHA.115.06461 　

ISSN：0194-911X

eISSN：1524-4563
Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study 査読有り

Zen Watanabe, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi

JOURNAL OF AFFECTIVE DISORDERS　190　341-348　2016年1月

DOI： 10.1016/j.jad.2015.10.024 　

ISSN：0165-0327

eISSN：1573-2517
ドラッグストア併設型薬局勤務薬剤師における家庭血圧測定に関する認識と実践

山口浩, 小原拓, 佐藤倫広, 阿部真也, 吉町昌子, 今井潤, 後藤輝明

医薬品相互作用研究　39　(2)　83-90　2015年12月
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
医薬品リスク管理計画に関する医薬情報担当者の認識査読有り

菊池大輔, 小原拓, 石井隆, 大内竜介, 三浦良祐, 山田尚之, 畑中貞雄

医薬品相互作用研究　39　(2)　91-94　2015年12月
出版者・発行元：医薬品相互作用研究会
ISSN：0385-5015
本態性高血圧患者における未治療時および降圧治療中の家庭血圧指標(収縮期、拡張期、平均、脈圧)の脳心血管イベント予測能 HOMED-BP研究査読有り

渡部大介, 浅山敬, 花澤智大, 安井大策, 井上隆輔, 保坂実樹, 佐藤倫広, 小原拓, 目時弘仁, 菊谷昌浩, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　38回　396-396　2015年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧に基づくアジルサルタンの臨床的評価査読有り

芳賀俊和, 佐藤倫広, 保坂実樹, 渡部大介, 小原拓, 目時弘仁, 浅山敬, 菊谷昌浩, 眞野成康, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　38回　397-397　2015年10月
出版者・発行元： (NPO)日本高血圧学会
不妊症既往と妊娠中の血圧との関連査読有り

石黒真美, 小原拓, 目時弘仁, 菊谷昌浩, 栗山進一, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　38回　406-406　2015年10月
出版者・発行元： (NPO)日本高血圧学会
新生児血圧に影響する要因の検討 BOSHI-新生児研究査読有り

井上隆輔, 目時弘仁, 大久保孝義, 小原拓, 菊谷昌浩, 佐藤倫広, 保坂実樹, 多田秀子, 八木橋香津代, 田中耕平, 星和彦, 森滋, 鈴木雅洲, 今井潤

日本高血圧学会総会プログラム・抄録集　38回　406-406　2015年10月
出版者・発行元： (NPO)日本高血圧学会
Prevalence, determinants, and reasons for the non-reporting of adverse drug reactions by pharmacists in the Miyagi and Hokkaido Regions of Japan 査読有り

Taku Obara, Hiroaki Yamaguchi, Michihiro Satoh, Yutaro Iida, Takamasa Sakai, Yoshiko Aoki, Yuriko Murai, Masaki Matsuura, Mayumi Sato, Takayoshi Ohkubo, Ken Iseki, Nariyasu Mano

Adv Pharmacoepidemiol Drug Saf　4　(5)　191　2015年9月

DOI： 10.4172/2167-1052.1000191 　
周産期における葉酸摂取の重要性に関する薬剤師の認識

酒井隆全, 小原拓, 竹林まゆみ, 水野恵司, 杉浦尚子, 竹内一仁, 大津史子, 瀬尾智子, 種村光代, 山崎嘉久, 村井ユリ子

日本薬剤師会雑誌　67　(6)　803-807　2015年6月
出版者・発行元： (公社)日本薬剤師会
ISSN：0369-674X
Awareness of the Japanese Society of Hypertension Guidelines for the Management of Hypertension and their use in clinical practices: 2009 survey results. 国際誌査読有り

Taku Obara, Sergio Ramón Gutiérrez Ubeda, Takayoshi Ohkubo, Hideo Matsuura, Toshihiko Ishimitsu, Masanobu Takata, Hiromi Rakugi, Yutaka Imai

Hypertension research : official journal of the Japanese Society of Hypertension　38　(6)　400-4　2015年6月

DOI： 10.1038/hr.2015.21 　

ISSN：0916-9636

詳細を見る詳細を閉じる

The objective of this study was to investigate physicians' awareness and use of the Japanese Society of Hypertension (JSH) Guidelines for the Management of Hypertension (JSH2004 and JSH2009), and determine what changes need to be implemented in the future. A questionnaire was used to survey physicians' awareness and their use of JSH2004 and JSH2009. Physicians attending educational seminars on hypertension that were held during the months after the publication of JSH2009 (January-April 2009) were asked to participate in the survey. Of the 5795 respondents, 88% were aware of the JSH2009 publication. Furthermore, physicians were also aware of JSH2004, with about 90% using JSH2004 in their practice. A hypertension blood pressure (BP) reference value of 140/90 mm Hg was used by 55% in office BP, whereas 31% used 135/85 mm Hg for home BP. Target BP levels used by physicians were 130/80 mm Hg for patients with diabetes or kidney disease (52%) and for elderly patients with diabetes or kidney disease (45%), whereas 140/90 mm Hg was used for elderly patients with low cardiovascular disease risk (44%) and for patients with chronic-phase stroke (27%). Answers to the questionnaire varied among physicians according to sex, age, workplace and specialty. The majority of the participating Japanese physicians were familiar with both JSH2004 and JSH2009, with many following the guidelines in their practice. However, some physicians use different reference values for hypertension and target BP levels. Physicians' adherence to and use of the guidelines should be regularly examined and promoted.
Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake 査読有り

Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　236　(2)　123-130　2015年6月

DOI： 10.1620/tjem.236.123 　

ISSN：0040-8727

eISSN：1349-3329
高血圧患者におけるβ遮断薬の家庭心拍減少および降圧効果検証のための介入研究 J-HOE-HR研究

新木貴大, 小原拓, 後ノ上健太, 芝宮拓, 佐藤倫広, 眞野成康, 今井潤, 大久保孝義, J-HOME-HR研究グループ

Therapeutic Research　36　(5)　429-438　2015年5月
出版者・発行元：ライフサイエンス出版(株)
ISSN：0289-8020
ドラッグストア併設型薬局薬剤師における周産期の葉酸摂取の重要性に関する認識

阿部真也, 小原拓, 佐藤倫広, 山口浩, 吉町昌子, 村井ユリ子, 後藤輝明

医薬品相互作用研究　38　(3)　150-155　2015年5月
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake 査読有り

Jun Hasegawa, Hiroshi Hidaka, Shinichi Kuriyama, Taku Obara, Ken Hashimoto, Yutaka Tateda, Yuri Okumura, Toshimitsu Kobayashi, Yukio Katori

PLOS ONE　10　(4)　2015年4月

DOI： 10.1371/journal.pone.0122631 　

ISSN：1932-6203
レセプトデータを用いた東北大学病院の本態性高血圧患者における降圧薬の処方動向調査

黒澤桂子, 佐藤倫広, 飯田優太郎, 小原拓, 松浦正樹, 井上隆輔, 高橋信行, 佐藤博, 村井ユリ子, 眞野成康

日本薬学会年会要旨集　135年会　(4)　134-134　2015年3月
出版者・発行元： (公社)日本薬学会
ISSN：0918-9823
Cup-shaped medication recording device for taking intraoral pictures 査読有り

Kenji Ishii, Yoko Kawai, Noriko Tsuruoka, Takahiro Fuse, Taku Obara, Tadao Matsunaga, Yutaka Imai, Yoichi Haga

IEEJ Transactions on Electronics, Information and Systems　135　(2)　197-203　2015年2月1日
出版者・発行元： Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejeiss.135.197 　

ISSN：1348-8155 0385-4221
Awareness regarding clinical application of pharmacogenetics among Japanese pharmacists 査読有り

Taku Obara, Taku Obara, Taku Obara, Shinya Abe, Michihiro Satoh, Sergio Ramón Gutiérrez Ubeda, Shoko Yoshimachi, Teruaki Goto

Pharmacogenomics and Personalized Medicine　8　35-41　2015年1月29日
出版者・発行元： Dove Medical Press Ltd
DOI： 10.2147/PGPM.S71813 　

ISSN：1178-7066
一般地域住民におけるセルフメディケーションの実態とその要因に関する調査大迫研究査読有り

佐藤倫広, 松本章裕, 原梓, 岩森紗希, 小原拓, 菊谷昌浩, 目時弘仁, 保坂実樹, 淺山敬, 高橋信行, 佐藤博, 眞野成康, 今井潤, 大久保孝義

薬学雑誌　134　(12)　1347-1355　2014年12月
出版者・発行元： (公社)日本薬学会
ISSN：0031-6903

eISSN：1347-5231
Surveys of postpartum depression in Miyagi, Japan, after the Great East Japan Earthquake 査読有り

Hidekazu Nishigori, Junichi Sugawara, Taku Obara, Toshie Nishigori, Kineko Sato, Takashi Sugiyama, Kunihiro Okamura, Nobuo Yaegashi

ARCHIVES OF WOMENS MENTAL HEALTH　17　(6)　579-581　2014年12月

DOI： 10.1007/s00737-014-0459-y 　

ISSN：1434-1816

eISSN：1435-1102
A Survey of Self-medication Practices and Related Factors in the General Population: the Ohasama Study 査読有り

Michihiro Satoh, Akihiro Matsumoto, Azusa Hara, Saki Iwamori, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Miki Hosaka, Kei Asayama, Nobuyuki Takahashi, Hiroshi Sato, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　134　(12)　1347-1355　2014年12月

ISSN：0031-6903
妊婦における尿中塩分排泄量と塩分・栄養診断システム算出の塩分摂取量の相関査読有り

佐藤倫広, 丹野由美, 保坂実樹, 目時弘仁, 小原拓, 淺山敬, 眞野成康, 星和彦, 鈴木雅洲, 今井潤

日本高血圧学会総会プログラム・抄録集　37回　370-370　2014年10月
出版者・発行元： (NPO)日本高血圧学会
本態性高血圧患者における家庭血圧と脳心血管疾患発症リスクの男女別解析 HOMED-BP研究査読有り

保坂実樹, 浅山敬, 佐藤倫広, 井上隆輔, 小原拓, 目時弘仁, 菊谷昌浩, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　37回　376-376　2014年10月
出版者・発行元： (NPO)日本高血圧学会
抗精神病薬と高血糖・糖尿病発症の関連レセプトデータに基づく検討

佐藤倫広, 小原拓, 大場延浩, 森川和彦, 西郡秀和, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　17回　158-158　2014年7月
出版者・発行元： (一社)日本医薬品情報学会
Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline The Ohasama Study 査読有り

Akihiro Matsumoto, Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Mikio Hirano, Ryusuke Inoue, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Aya Hosokawa, Kazuhito Totsune, Haruhisa Hoshi, Toru Hosokawa, Hiroshi Sato, Yutaka Imai

HYPERTENSION　63　(6)　1333-1338　2014年6月

DOI： 10.1161/HYPERTENSIONAHA.113.01819 　

ISSN：0194-911X

eISSN：1524-4563
家庭血圧に基づく血漿アルドステロン濃度/血漿レニン活性比とNon-dippingの関連大迫研究

佐藤倫広, 保坂実樹, 菊谷昌浩, 淺山敬, 井上隆輔, 坪田恵, 原梓, 廣瀬卓男, 小原拓, 目時弘仁, 戸恒和人, 星晴久, 眞野成康, 今井潤, 大久保孝義

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　3回　115-115　2014年5月
出版者・発行元： (NPO)日本高血圧学会
Consumption of fruits, vegetables, and seaweeds (sea vegetables) and pancreatic cancer risk: The Ohsaki Cohort Study 査読有り

Michiko Shigihara, Taku Obara, Masato Nagai, Yumi Sugawara, Takashi Watanabe, Masako Kakizaki, Yoshikazu Nishino, Shinichi Kuriyama, Ichiro Tsuji

CANCER EPIDEMIOLOGY　38　(2)　129-136　2014年4月

DOI： 10.1016/j.canep.2014.01.001 　

ISSN：1877-7821

eISSN：1877-783X
Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis 査読有り

Kei Asayama, Lutgarde Thijs, Jana Brguljan-Hitij, Teemu J. Niiranen, Atsushi Hozawa, José Boggia, Lucas S. Aparicio, Azusa Hara, Jouni K. Johansson, Takayoshi Ohkubo, Christophe Tzourio, George S. Stergiou, Edgardo Sandoya, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen, K. Asayama, T. Ohkubo, M. Kikuya, R. Inoue, M. Satoh, M. Hosaka, M. T. Utsugi, T. Hirose, A. Hara, N. Fukushima, T. Obara, H. Metoki, Y. Imai, J. Johansson, A. Reunanen, A. Jula, K. Ohmori-Matsuda, S. Kuriyama, M. Kakizaki, A. Hozawa, I. Tsuji, T. Mountokalakis, A. Kollias, G. Thomopoulou, P. Kalogeropoulos, I. Skeva, E. Nasothimiou, N. Pantazis, N. Baibas, J. Boggia, E. Sandoya, J. A. Staessen, L. Thijs, N. Cauwenberghs, Z. Zhang, F. Wei, J. Knez, A. Odili, Y. Gu, Y. Liu, Y. Jin, L. Jacobs, T. Kuznetzova

PLoS Medicine　11　(1)　e1001591　2014年1月1日
出版者・発行元： Public Library of Science
DOI： 10.1371/journal.pmed.1001591 　

ISSN：1549-1676 1549-1277
The velocity of home blood pressure reduction in response to low-dose eplerenone combined with other antihypertensive drugs determined by exponential decay function analysis 査読有り

Noha Elnagar, Michihiro Satoh, Miki Hosaka, Kei Asayama, Kazuki Ishikura, Taku Obara, Nariyasu Mano, Takayoshi Ohkubo, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　36　(2)　83-91　2014年

DOI： 10.3109/10641963.2014.892117 　

ISSN：1064-1963

eISSN：1525-6006
Aldosterone-to-renin ratio and nocturnal blood pressure decline assessed by self-measurement of blood pressure at home: the Ohasama Study 査読有り

Michihiro Satoh, Miki Hosaka, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Megumi T. Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Takefumi Mori, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

CLINICAL AND EXPERIMENTAL HYPERTENSION　36　(2)　108-114　2014年

DOI： 10.3109/10641963.2014.892121 　

ISSN：1064-1963

eISSN：1525-6006
Night-time blood pressure is associated with the development of chronic kidney disease in a general population: The Ohasama Study 査読有り

Atsuhiro Kanno, Masahiro Kikuya, Kei Asayama, Michihiro Satoh, Ryusuke Inoue, Miki Hosaka, Hirohito Metoki, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Toshinobu Sato, Yoshio Taguma, Hiroshi Sato, Yutaka Imai, Takayoshi Ohkubo

Journal of Hypertension　31　(12)　2410-2417　2013年12月

DOI： 10.1097/HJH.0b013e328364dd0f 　

ISSN：0263-6352 1473-5598
日本の一般地域住民におけるセルフメディケーションに関する実態調査

佐藤倫広, 松本章裕, 原梓, 岩森紗希, 菊谷昌浩, 小原拓, 目時弘仁, 小野木弘志, 高橋信行, 佐藤博, 眞野成康, 今井潤, 大久保孝義

日本補完代替医療学会学術集会プログラム・抄録集　16回　58-58　2013年11月
出版者・発行元：日本補完代替医療学会
周産期の葉酸摂取の重要性に関する薬剤師の認識

小原拓, 佐藤倫広, 小野木弘志, 眞野成康, 村井ユリ子

日本補完代替医療学会学術集会プログラム・抄録集　16回　64-64　2013年11月
出版者・発行元：日本補完代替医療学会
微量アルブミン尿を呈する高血圧症患者に対するイルベサルタン単独治療および併用治療が腎機能、家庭血圧に及ぼす効果多施設共同無作為比較研究(J-HOMEアルブミン研究)

井上隆輔, 大久保孝義, 菊谷昌浩, 目時弘仁, 小原拓, 佐藤倫広, 今井潤

日本高血圧学会総会プログラム・抄録集　36回　269-269　2013年10月
出版者・発行元： (NPO)日本高血圧学会
一般地域住民における、家庭血圧および24時間血圧に基づく真性および部分白衣高血圧と脳卒中発症の関連大迫研究

佐藤倫広, 菊谷昌浩, 浅山敬, 井上隆輔, 宇津木恵[坪田], 原梓, 廣瀬卓男, 小原拓, 目時弘仁, 戸恒和人, 星晴久, 眞野成康, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　36回　321-321　2013年10月
出版者・発行元： (NPO)日本高血圧学会
Logistic regression analysis of risk factors for prolonged pulmonary recovery in children from aspirated foreign body 査読有り

Hiroshi Hidaka, Taku Obara, Shinichi Kuriyama, Shin Kurosawa, Yukio Katori, Toshimitsu Kobayashi

International Journal of Pediatric Otorhinolaryngology　77　(10)　1677-1682　2013年10月

DOI： 10.1016/j.ijporl.2013.07.024 　

ISSN：0165-5876 1872-8464
小児の注意欠陥/多動性障害患者に対する医薬品処方

小原拓, 佐藤倫広, 村井ユリ子, 眞野成康, 栗山進一

日本医薬品情報学会総会・学術大会講演要旨集　16回　131-131　2013年8月
出版者・発行元： (一社)日本医薬品情報学会
インターネット上の「葉酸と妊娠」に関する情報の現状

村井ユリ子, 猪狩有紀恵, 石黒真美, 佐藤倫広, 小原拓

日本医薬品情報学会総会・学術大会講演要旨集　16回　139-139　2013年8月
出版者・発行元： (一社)日本医薬品情報学会
葉酸と出生児の神経管閉鎖障害リスク抑制に関する薬学生の認識

大原宏司, 小原拓, 佐藤倫広, 眞野成康, 佐藤博, 早坂正孝, 村井ユリ子

日本医薬品情報学会総会・学術大会講演要旨集　16回　140-140　2013年8月
出版者・発行元： (一社)日本医薬品情報学会
東日本大震災後に薬品情報室に寄せられた問い合わせに関する調査

吉中千佳, 尾崎芙実, 小原拓, 草場美津江, 前川麻央, 松浦正樹, 佐賀利英, 中村浩規, 久道周彦, 佐藤真由美, 我妻恭行, 眞野成康

日本病院薬剤師会雑誌　49　(8)　877-881　2013年8月
出版者・発行元： (一社)日本病院薬剤師会
ISSN：1341-8815
薬剤師における医薬品安全性評価に関する認識および実践に関する調査

山口浩明, 小原拓, 佐藤倫広, 青木良子, 天沼喜美子, 村井ユリ子, 宮本剛典, 高村茂生, 山田武宏, 眞野成康, 井関健

日本医薬品情報学会総会・学術大会講演要旨集　16回　122-122　2013年8月
出版者・発行元： (一社)日本医薬品情報学会
周産期における葉酸摂取の重要性に関する薬剤師の認識

酒井隆全, 小原拓, 竹林まゆみ, 水野恵司, 杉浦尚子, 竹内一仁, 大津史子, 村井ユリ子

日本医薬品情報学会総会・学術大会講演要旨集　16回　140-140　2013年8月
出版者・発行元： (一社)日本医薬品情報学会
妊娠期間中の家庭血圧は正常であったが急速に妊娠高血圧腎症・子癇発作を発症した1例査読有り

目時弘仁, 渋谷祐介, 岩間憲之, 片桐未希子, 小原拓, 菊谷昌浩, 大久保孝義, 西郡秀和, 佐藤尚明, 田中耕平, 星和彦, 鈴木雅洲, 今井潤, 菅原準一, 八重樫伸生

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　2回　152-152　2013年5月
出版者・発行元： (NPO)日本高血圧学会
ラニチジン注とファモチジン注のパクリタキセル注前投与におけるアレルギー発現率の比較

片岡佑太, 菊地正史, 中川直人, 木皿重樹, 高橋哉子, 小笠原喜美代, 我妻恭行, 久道周彦, 小原拓, 鈴木直人, 村井ユリ子, 島田美樹, 富岡佳久, 石岡千加史, 眞野成康

日本薬学会年会要旨集　133年会　(4)　184-184　2013年3月
出版者・発行元： (公社)日本薬学会
ISSN：0918-9823
Breastfeeding leads to lower blood pressure in 7-year-old Japanese children: Tohoku Study of Child Development (vol 36, pg 117, 2012) 査読有り

Hosaka Miki, Asayama Kei, Staessen Jan A, Ohkubo Takayoshi, Hayashi Katsuhisa, Tatsuta Nozomi, Kurokawa Naoyuki, Satoh Michihiro, Hashimoto Takanao, Hirose Takuo, Obara Taku, Metoki Hirohito, Inoue Ryusuke, Kikuya Masahiro, Nakai Kunihiko, Imai Yutaka, Satoh Hiroshi

HYPERTENSION RESEARCH　36　(2)　184　2013年2月

DOI： 10.1038/hr.2012.203 　

ISSN：0916-9636
妊婦における葉酸サプリメント摂取の評価BOSHI研究査読有り

小原拓, 村井ユリ子, 眞野成康

医薬品相互作用研究　37　37-43　2013年
Compliance to the recommendations on blood pressure measurements in the clinical settings. 査読有り

Obara Taku, Ohkubo Takayoshi, Mano Nariyasu, Kuriyama Shinichi, Imai Yutaka

J Hypertens　31　(1)　213-213　2013年1月

DOI： 10.1097/HJH.0b013e32835aaffd 　

ISSN：0263-6352
カンデサルタン8mg/HCTZ6.25mg配合剤とカンデサルタン12mgの家庭血圧/外来血圧に及ぼす作用に関する多施設共同無作為比較試験(J-HOME-CARD研究) 主結果報告

今井潤, 保坂実樹, 目時弘仁, 佐藤倫広, 小原拓, 菊谷昌浩, 大久保孝義, J-HOME-CARD研究グループ

日本高血圧学会総会プログラム・抄録集　35回　468-468　2012年9月
出版者・発行元： (NPO)日本高血圧学会
Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study 査読有り

Atsuhiro Kanno, Masahiro Kikuya, Takayoshi Ohkubo, Takanao Hashimoto, Michihiro Satoh, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoh Shishido, Haruhisa Hoshi, Masaaki Nakayama, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

NEPHROLOGY DIALYSIS TRANSPLANTATION　27　(8)　3218-3223　2012年8月

DOI： 10.1093/ndt/gfs054 　

ISSN：0931-0509
Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama Study 査読有り

Shiho Terata, Masahiro Kikuya, Michihiro Satoh, Takayoshi Ohkubo, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

JOURNAL OF HYPERTENSION　30　(8)　1632-1638　2012年8月

DOI： 10.1097/HJH.0b013e328354f65b 　

ISSN：0263-6352
Aldosterone-to-Renin Ratio as a Predictor of Stroke Under Conditions of High Sodium Intake: The Ohasama Study 査読有り

Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Azusa Hara, Megumi T. Utsugi, Takanao Hashimoto, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　25　(7)　777-783　2012年7月

DOI： 10.1038/ajh.2012.33 　

ISSN：0895-7061
東日本大震災後に薬品情報室に寄せられた問い合わせに関する調査

吉中千佳, 尾崎芙実, 小原拓, 前川麻央, 草場美津江, 佐賀利英, 我妻恭行, 久道周彦, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　15回　120-120　2012年6月
出版者・発行元： (一社)日本医薬品情報学会
Predictive Value for Mortality of the Double Product at Rest Obtained by Home Blood Pressure Measurement: The Ohasama Study 査読有り

Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　25　(5)　568-575　2012年5月

DOI： 10.1038/ajh.2012.3 　

ISSN：0895-7061
うつ症状、労働状況、および睡眠薬・抗不安薬服用状況に関する社団法人仙台市薬剤師会による実態調査

佐藤倫広, 小原拓, 高橋將喜, 早坂正孝, 鎌田裕, 北村哲治

医薬品相互作用研究　35　(3)　153-158　2012年4月
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
妊娠と医薬品使用に関する問い合わせ内容の調査査読有り

小原拓, 尾崎芙実, 吉中千佳, 前川麻央, 草場美津江, 石黒真美, 飯田優太郎, 鈴木文子, 松浦正樹, 佐賀利英, 佐藤真由美, 久道周彦, 島田美樹, 栗山進一, 八重樫伸生, 眞野成康

医薬品相互作用研究　35　(3)　129-133　2012年4月
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
シンバスタチン服用前後の脂質・血糖・血圧の変化市販後調査データを用いた検討査読有り

小原拓, 村井ユリ子, 眞野成康

医薬品相互作用研究　36 (2)　114-119　2012年
葉酸の神経管閉鎖障害リスク低下効果に関する薬剤師の認識

小原拓, 村井ユリ子, 猪狩有紀恵, 原梓, 岸川幸生, 早坂正孝, 鎌田裕, 眞野成康, 高橋将喜, 生出泉太郎, 北村哲治

医薬品情報学　13　(4)　167-172　2012年

DOI： 10.11256/jjdi.13.167 　
Validation of the Parama-Tech PS-501 Device for Office Blood Pressure Measurement According to the International Protocol 査読有り

Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Kei Asayama, Kazuhito Totsune, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　34　(1)　71-73　2012年

DOI： 10.3109/10641963.2011.618198 　

ISSN：1064-1963
Prognostic Significance of Home Arterial Stiffness Index Derived From Self-Measurement of Blood Pressure: The Ohasama Study 査読有り

Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Kei Asayama, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Jan A. Staessen, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　25　(1)　67-73　2012年1月

DOI： 10.1038/ajh.2011.167 　

ISSN：0895-7061
Daily Serial Hemodynamic Data During Pregnancy and Seasonal Variation: The BOSHI Study 査読有り

Hirohito Metoki, Takayoshi Ohkubo, Taku Obara, Konomi Akutsu, Mami Yamamoto, Mami Ishikuro, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Junichi Sugawara, Takuo Hirose, Michihiro Sato, Masahiro Kikuya, Katsuyo Yagihashi, Yoichi Matsubara, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　34　(4)　290-296　2012年

DOI： 10.3109/10641963.2012.681086 　

ISSN：1064-1963
家庭血圧測定に基づく震災前後の家庭血圧・脈拍の推移

佐藤倫広, 菊谷昌浩, 大久保孝義, 目時弘仁, 小原拓, 浅山敬, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　325-325　2011年10月
出版者・発行元： (NPO)日本高血圧学会
Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population: the Ohasama study 査読有り

Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Takanao Hashimoto, Azusa Hara, Megumi T. Utsugi, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

JOURNAL OF HYPERTENSION　29　(10)　1940-1947　2011年10月

DOI： 10.1097/HJH.0b013e32834ab46a 　

ISSN：0263-6352

eISSN：1473-5598
Subtypes of Resistant Hypertension Based on Out-of-Office Blood Pressure Measurement 査読有り

Taku Obara, Takayoshi Ohkubo, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama, Yutaka Imai

HYPERTENSION　58　(4)　E28-E28　2011年10月

DOI： 10.1161/HYPERTENSIONAHA.111.178996 　

ISSN：0194-911X
Aldosterone-to-renin ratio and home blood pressure in subjects with higher and lower sodium intake: the Ohasama Study 査読有り

Michihiro Satoh, Masahiro Kikuya, Azusa Hara, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Megumi T. Utsugi, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

HYPERTENSION RESEARCH　34　(3)　361-366　2011年3月

DOI： 10.1038/hr.2010.236 　

ISSN：0916-9636
How many measurements are needed to provide reliable information in terms of the ambulatory arterial stiffness index? the Ohasama study 査読有り

Masahiro Kikuya, Jan A. Staessen, Takayoshi Ohkubo, Lutgarde Thijs, Kei Asayama, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Yan Li, Eamon Dolan, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Ji-Guang Wang, Eoin O'Brien, Yutaka Imai

HYPERTENSION RESEARCH　34　(3)　314-318　2011年3月

DOI： 10.1038/hr.2010.240 　

ISSN：0916-9636
Association of Arterial Stiffness with Silent Cerebrovascular Lesions: The Ohasama Study 査読有り

Rieko Hatanaka, Taku Obara, Daisuke Watabe, Tomofumi Ishikawa, Takeo Kondo, Kazuki Ishikura, Tomoyuki Aikawa, Yoko Aono, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Nariyasu Mano, Takayoshi Ohkubo, Shin-Ichi Izumi, Yutaka Imai

CEREBROVASCULAR DISEASES　31　(4)　329-337　2011年

DOI： 10.1159/000322599 　

ISSN：1015-9770
妊娠前後における女性のサプリメント摂取：BOSHI研究査読有り

原梓, 小原拓, 目時弘仁, 大久保孝義, 川口麻衣子, 佐藤友里恵, 佐々木彩乃, 星川美奈子, 石倉一樹, 佐藤倫広, 村井ユリ子, 眞野成康, 岩崎雅弘, 八木橋香津代, 森滋, 八重樫伸生, 鈴木雅洲, 今井潤

医薬品相互作用研究　35　(1)　11-16　2011年
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
Individual Assessment of Inherent Arterial Stiffness Using Nomogram and Pulse Wave Velocity Index: The Ohasama Study 査読有り

Rieko Hatanaka, Taku Obara, Daisuke Watabe, Atsushi Kimura, Tomohiro Hanazawa, Hiromi Ohba, Tomofumi Ishikawa, Tomoyuki Aikawa, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Kazuhito Totsune, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(3)　147-152　2011年

DOI： 10.3109/10641963.2010.531839 　

ISSN：1064-1963
Self-Monitoring of Ambulatory Blood Pressure by the Microlife WatchBP O3-An Application Test 査読有り

Hajime Nakano, Masahiro Kikuya, Azusa Hara, Manami Nakashita, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takayoshi Ohkubo, Kazuhito Totsune, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(1)　34-40　2011年

DOI： 10.3109/10641963.2010.503300 　

ISSN：1064-1963
Low-Dose and Very Low-Dose Spironolactone in Combination Therapy for Essential Hypertension: Evaluation by Self-Measurement of Blood Pressure at Home 査読有り

Tomohiro Hanazawa, Taku Obara, Kei Ogasawara, Takahiro Shinki, Sakiko Katada, Ryusuke Inoue, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Nariyasu Mano, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(7)　427-436　2011年

DOI： 10.3109/10641963.2010.531844 　

ISSN：1064-1963

eISSN：1525-6006
Associated Factors of Home Versus Ambulatory Heart Rate Variability in the General Population: The Ohasama Study 査読有り

Kenta Gonokami, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(6)　404-410　2011年

DOI： 10.3109/10641963.2010.549269 　

ISSN：1064-1963
Serum Magnesium, Ambulatory Blood Pressure, and Carotid Artery Alteration: The Ohasama Study 査読有り

Takanao Hashimoto, Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Manami Nakashita, Shiho Terata, Taku Obara, Takuo Hirose, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　23　(12)　1292-1298　2010年12月

DOI： 10.1038/ajh.2010.168 　

ISSN：0895-7061
家庭血圧によるHome Arterial Stiffness Index(HASI)の脳卒中発症予測能

菊谷昌浩, 大久保孝義, 佐藤倫広, 廣瀬卓男, 橋本貴尚, 目時弘仁, 井上隆輔, 小原拓, 浅山敬, 星晴久, 戸恒和人, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　33回　283-283　2010年10月
出版者・発行元： (NPO)日本高血圧学会
薬剤師における家庭血圧測定に関する認識と実践

小林満, 小原拓, 田中宏治, 佐藤倫広, 生出泉太郎, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　33回　418-418　2010年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧測定に基づくドキサゾシンメシル酸塩錠の臨床評価先発医薬品(カルデナリン錠)から後発医薬品(カデメシン錠・メシル酸ドキサゾシン「MEEK」錠)への切り替え

池田うらら, 小原拓, 新木貴大, 芝宮拓, 石倉一樹, 佐藤倫広, 大久保孝義, 吉田克己, 今井潤

医薬品相互作用研究　34　(1)　7-12　2010年9月
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
Relationship of dysregulation of glucose metabolism with white-coat hypertension: the Ohasama study 査読有り

Miki Hosaka, Akira Mimura, Kei Asayama, Takayoshi Ohkubo, Katsuhisa Hayashi, Masahiro Kikuya, Michihiro Sato, Takanao Hashimoto, Atsuhiro Kanno, Azusa Hara, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Haruhisa Hoshi, Hiroshi Satoh, Yoshitomo Oka, Yutaka Imai

HYPERTENSION RESEARCH　33　(9)　937-943　2010年9月

DOI： 10.1038/hr.2010.114 　

ISSN：0916-9636
Factors Associated With Day-By-Day Variability of Self-Measured Blood Pressure at Home: The Ohasama Study 査読有り

Tetsuo Kato, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Azusa Hara, Taku Obara, Hirohito Metoki, Kei Asayama, Takuo Hirose, Ryusuke Inoue, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　23　(9)　980-986　2010年9月

DOI： 10.1038/ajh.2010.94 　

ISSN：0895-7061
Practice and awareness of physicians regarding casual-clinic blood pressure measurement in Japan 査読有り

Mitsuru Kobayashi, Taku Obara, Takayoshi Ohkubo, Hidefumi Fukunaga, Michihiro Satoh, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Masaaki Miyakawa, Yutaka Imai

Hypertension Research　33　(9)　960-964　2010年9月

DOI： 10.1038/hr.2010.89 　

ISSN：0916-9636 1348-4214
Electrocardiographic abnormalities and home blood pressure in treated elderly hypertensive patients: Japan home versus office blood pressure measurement evaluation in the elderly (J-HOME-Elderly) study 査読有り

Taku Shibamiya, Taku Obara, Takayoshi Ohkubo, Takahiro Shinki, Kazuki Ishikura, Makoto Yoshida, Michihiro Satoh, Takanao Hashimoto, Azusa Hara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Yutaka Imai

HYPERTENSION RESEARCH　33　(7)　670-677　2010年7月

DOI： 10.1038/hr.2010.55 　

ISSN：0916-9636

eISSN：1348-4214
Stroke Risk in Treated Hypertension Based on Home Blood Pressure: the Ohasama Study 査読有り

Daisaku Yasui, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Atsuhiro Kanno, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　23　(5)　508-514　2010年5月

DOI： 10.1038/ajh.2010.15 　

ISSN：0895-7061

eISSN：1941-7225
Practice and awareness of physicians regarding home blood pressure measurement in Japan 査読有り

Taku Obara, Takayoshi Ohkubo, Hidefumi Fukunaga, Mitsuru Kobayashi, Michihiro Satoh, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Masaaki Miyakawa, Yutaka Imai

Hypertension Research　33　(5)　428-434　2010年5月

DOI： 10.1038/hr.2010.10 　

ISSN：0916-9636 1348-4214
高血圧患者における一包化調剤対応服薬コンプライアンス計の臨床応用

西村美里, 小原拓, 駒井理恵, 村井華代, 田中宏治, 加藤哲夫, 佐藤倫広, 原梓, 目時弘仁, 浅山敬, 菊谷昌浩, 大久保孝義, 今井潤

医薬品相互作用研究　33　(3)　97-102　2010年4月
出版者・発行元： (一社)医薬品相互作用研究会
ISSN：0385-5015
Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study 査読有り

Yumiko Watanabe, Hirohito Metoki, Takayoshi Ohkubo, Tomohiro Katsuya, Yasuharu Tabara, Masahiro Kikuya, Takuo Hirose, Ken Sugimoto, Kei Asayama, Ryusuke Inoue, Azusa Hara, Taku Obara, Jun Nakura, Katsuhiko Kohara, Kazuhito Totsune, Toshio Ogihara, Hiromi Rakugi, Tetsuro Miki, Yutaka Imai

HYPERTENSION RESEARCH　33　(2)　129-134　2010年2月

DOI： 10.1038/hr.2009.193 　

ISSN：0916-9636

eISSN：1348-4214
Parental longevity and offspring's home blood pressure: the Ohasama study 査読有り

Yumiko Watanabe, Hirohito Metoki, Takayoshi Ohkubo, Takuo Hirose, Masahiro Kikuya, Kei Asayama, Ryusuke Inoue, Azusa Hara, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Yutaka Imai

JOURNAL OF HYPERTENSION　28　(2)　272-277　2010年2月

DOI： 10.1097/HJH.0b013e328332fa78 　

ISSN：0263-6352

eISSN：1473-5598
Blood Pressure-Lowering Effect and Duration of Action of Bedtime Administration of Doxazosin Determined by Home Blood Pressure Measurement 査読有り

Kenta Gonokami, Taku Obara, Mitsuru Kobayashi, Sakiko Katada, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　32　(5)　311-317　2010年

DOI： 10.3109/10641960903443541 　

ISSN：1064-1963
Validation of the FM-800 Ambulatory Blood Pressure Monitor According to the Association for the Advancement of Medical Instrumentation Criteria and the International Protocol 査読有り

Kaori Nakamura, Masahiro Kikuya, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Takayoshi Ohkubo, Kazuhito Totsune, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　32　(8)　523-527　2010年

DOI： 10.3109/10641963.2010.496513 　

ISSN：1064-1963
Association of Kidney Dysfunction with Silent Lacunar Infarcts and White Matter Hyperintensity in the General Population: The Ohasama Study 査読有り

Harunori Otani, Masahiro Kikuya, Azusa Hara, Shiho Terata, Takayoshi Ohkubo, Takeo Kondo, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Hiroyuki Terawaki, Masaaki Nakayama, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

CEREBROVASCULAR DISEASES　30　(1)　43-50　2010年

DOI： 10.1159/000313612 　

ISSN：1015-9770

eISSN：1421-9786
Uncontrolled hypertension based on morning and evening home blood pressure measurements from the J-HOME study 査読有り

Taku Obara, Kie Ito, Takayoshi Ohkubo, Taku Shibamiya, Takahiro Shinki, Manami Nakashita, Azusa Hara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Nariyasu Mano, Yutaka Imai

HYPERTENSION RESEARCH　32　(12)　1072-1078　2009年12月

DOI： 10.1038/hr.2009.152 　

ISSN：0916-9636

eISSN：1348-4214
降圧効果安定までの期間と降圧効果についてのロサルタン/HCTZとARB最大容量との比較 J-HOME-AI研究

目時弘仁, 堅田早紀子, 小原拓, 菅野厚博, 大久保孝義, 今井潤, J-HOME-AI研究グループ

日本高血圧学会総会プログラム・抄録集　32回　282-282　2009年10月
出版者・発行元： (NPO)日本高血圧学会
Influence of home blood pressure measuring conditions in the evening on the morning-evening home blood pressure difference in treated hypertensive patients: the J-HOME study 査読有り

Kie Ito, Taku Obara, Takayoshi Ohkubo, Kenta Gonokami, Takahiro Shinki, Taku Shibamiya, Manami Nakashita, Mitsuru Kobayashi, Jin Funahashi, Azusa Hara, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Yutaka Imai

BLOOD PRESSURE MONITORING　14　(4)　160-165　2009年8月

DOI： 10.1097/MBP.0b013e32832e2a40 　

ISSN：1359-5237
Repeated evening home blood pressure measurement improves prognostic significance for stroke: a 12-year follow-up of the Ohasama study 査読有り

Kei Asayama, Takayoshi Ohkubo, Azusa Hara, Takuo Hirose, Daisaku Yasui, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

BLOOD PRESSURE MONITORING　14　(3)　93-98　2009年6月

DOI： 10.1097/MBP.0b013e32832a9d91 　

ISSN：1359-5237
Detection of silent cerebrovascular lesions in individuals with 'masked' and 'white-coat' hypertension by home blood pressure measurement: the Ohasama study 査読有り

Azusa Hara, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Yoko Aono, Sugiko Hanawa, Kyoko Shioda, Sayaka Miyamoto, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takuo Hirose, Kazuhito Totsune, Haruhisa Hoshi, Shin-Ichi Izumi, Hiroshi Satoh, Yutaka Imai

JOURNAL OF HYPERTENSION　27　(5)　1049-1055　2009年5月

DOI： 10.1097/HJH.0b013e3283298522 　

ISSN：0263-6352
Day-by-Day Variability of Blood Pressure and Heart Rate at Home as a Novel Predictor of Prognosis The Ohasama Study 査読有り

Masahiro Kikuya, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Azusa Hara, Taku Obara, Ryusuke Inoue, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

HYPERTENSION　52　(6)　1045-1050　2008年12月

DOI： 10.1161/HYPERTENSIONAHA.107.104620 　

ISSN：0194-911X
大迫研究から日本の高血圧治療ガイドラインに基づいた脳卒中リスク分類

浅山敬, 大久保孝義, 菊谷昌浩, 廣瀬卓男, 原梓, 菅野厚博, 安井大策, 小原拓, 目時弘仁, 井上隆輔, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

血圧　15　(10)　902-903　2008年10月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
家庭血圧導入の医療経済学的評価外来血圧コントロール良好高血圧患者における検討

田巻佑一朗, 中川美和, 大久保孝義, 小林慎, 福永英史, 菊谷昌浩, 小原拓, 原梓, 浅山敬, 目時弘仁, 井上隆輔, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　207-207　2008年10月
出版者・発行元： (NPO)日本高血圧学会
高血圧治療ガイドラインに基づいたリスク分類大迫研究

浅山敬, 大久保孝義, 菊谷昌浩, 廣瀬卓男, 原梓, 菅野厚博, 安井大策, 小原拓, 目時弘仁, 井上隆輔, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　208-208　2008年10月
出版者・発行元： (NPO)日本高血圧学会
自由行動下心拍短期変動と家庭心拍日間変動の規定要因に関する検討大迫研究

後ノ上健太, 菊谷昌浩, 大久保孝義, 原梓, 目時弘仁, 浅山敬, 井上隆輔, 小原拓, 廣瀬卓男, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　214-214　2008年10月
出版者・発行元： (NPO)日本高血圧学会
AASIおよび24時間脈圧の再現性・予後予測能全血圧値および一部の血圧値による検討大迫研究

菊谷昌浩, Staessen Jan A., 大久保孝義, Thijs Lutgarde, 目時弘仁, 浅山敬, 小原拓, 井上隆輔, Li Yan, Dolan Eamon, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, Wang Ji-Guang, O'Brien Eoin, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　284-284　2008年10月
出版者・発行元： (NPO)日本高血圧学会
血清マグネシウム濃度・24時間自由行動下血圧と頸動脈硬化指標との関連大迫研究

橋本貴尚, 原梓, 大久保孝義, 菊谷昌浩, 新谷依子, 目時弘仁, 井上隆輔, 浅山敬, 菅野厚博, 中下愛実, 小原拓, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　285-285　2008年10月
出版者・発行元： (NPO)日本高血圧学会
家庭ダブルプロダクトと予後大迫研究より

井上隆輔, 大久保孝義, 菊谷昌浩, 浅山敬, 目時弘仁, 原梓, 廣瀬卓男, 菅野厚博, 小原拓, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 根東義明, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　286-286　2008年10月
出版者・発行元： (NPO)日本高血圧学会
非飲酒者における就寝前家庭血圧の有用性大迫研究

浅山敬, 大久保孝義, 菅野厚博, 原梓, 廣瀬卓男, 安井大策, 小原拓, 目時弘仁, 井上隆輔, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　313-313　2008年10月
出版者・発行元： (NPO)日本高血圧学会
わが国の家庭血圧測定の現状と変化外来患者の実践と意識"家庭血圧測定の現状に関する調査研究-2"

大久保孝義, 小原拓, 原梓, 小林満, 目時弘仁, 浅山敬, 菊谷昌宏, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　316-316　2008年10月
出版者・発行元： (NPO)日本高血圧学会
Predictive value of ambulatory heart rate in the Japanese general population: the Ohasama study 査読有り

Atsushi Hozawa, Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Azusa Hara, Takuo Hirose, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

JOURNAL OF HYPERTENSION　26　(8)　1571-1576　2008年8月

ISSN：0263-6352
脂質異常症患者における先発医薬品(ベザトールSR)から後発医薬品(ベザテートSR)への切り替えに関する臨床評価

小原拓, 高橋將喜, 高橋則男, 高橋武, 小林寛子, 猪狩有紀恵, 大久保孝義, 齋藤真一郎, 眞野成康, 今井潤

医薬品相互作用研究　32　(1)　33-37　2008年7月
出版者・発行元：医薬品相互作用研究会
ISSN：0385-5015
脂質異常症治療薬の後発医薬品への切り替えと服薬コンプライアンスの変化

小原拓, 高橋將喜, 高橋則男, 高橋武, 小林寛子, 猪狩有紀恵, 齋藤真一郎, 大久保孝義, 眞野成康, 今井潤

ジェネリック研究　2　(増刊号)　74-74　2008年6月
出版者・発行元：日本ジェネリック医薬品・バイオシミラー学会
ISSN：1881-9117
Difference between home and office blood pressures among treated hypertensive patients from the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study 査読有り

Tsuyoshi Horikawa, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

HYPERTENSION RESEARCH　31　(6)　1115-1123　2008年6月

ISSN：0916-9636
Optimal cutoff point of waist circumference and use of home blood pressure as a definition of metabolic syndrome: The Ohasama study 査読有り

Atsushi Sato, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Azusa Hara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshitomo Oka, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　21　(5)　514-520　2008年5月

DOI： 10.1038/ajh.2007.88 　

ISSN：0895-7061
血清マグネシウム濃度と頸動脈硬化指標の横断的検討大迫研究

橋本貴尚, 新谷依子, 原梓, 菊谷昌浩, 大久保孝義, 大谷陽範, 田中一翔, 浅山敬, 井上隆輔, 目時弘仁, 小原拓, 森戸里衣子, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本循環器病予防学会誌　43　(1)　77-86　2008年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
Cost-effectiveness of the introduction of home blood pressure measurement in patients with office hypertension 査読有り

Hidefumi Fukunaga, Takayoshi Ohkubo, Makoto Kobayashi, Yuichiro Tamaki, Masahiro Kikuya, Taku Obara, Miwa Nakagawa, Azusa Hara, Kei Asayama, Hirohito Metoki, Ryusuke Inoue, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

JOURNAL OF HYPERTENSION　26　(4)　685-690　2008年4月

ISSN：0263-6352

eISSN：1473-5598
日本の高血圧診療に家庭血圧測定を導入した場合の費用対効果分析

福永英史, 田巻佑一朗, 小原拓, 戸恒和人, 鈴木一夫, 大久保孝義, 菊谷昌浩, 目時弘仁, 橋本潤一郎, 今井潤, 小林慎, 中川美和, 浅山敬

医療経済研究　19　(3)　211-232　2008年3月
出版者・発行元：医療経済研究機構
ISSN：1340-895X
Home blood pressure measurements associated with better blood pressure control: the J-HOME study 査読有り

T. Obara, T. Ohkubo, K. Asayama, H. Metoki, R. Inoue, M. Kikuya, T. Kato, K. Tanaka, A. Hara, J. Hashimoto, K. Totsune, Y. Imai

JOURNAL OF HUMAN HYPERTENSION　22　(3)　197-204　2008年3月

DOI： 10.1038/sj.jhh.1002320 　

ISSN：0950-9240
Time-dependent effects of imidapril administration in patients with morning hypertension measured as home blood pressure 査読有り

Takako Shibasaki, Taku Obara, Takayoshi Ohkubo, Azusa Hara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　30　(3-4)　243-254　2008年

DOI： 10.1080/10641960802069806 　

ISSN：1064-1963
Prevalence of masked hypertension in subjects treated with antihypertensive drugs as assessed by morning versus evening home blood pressure measurements: The J-HOME study 査読有り

Taku Obara, Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Rie Komai, Kayo Murai, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　30　(3-4)　277-287　2008年

DOI： 10.1080/10641960802071018 　

ISSN：1064-1963
II型糖尿病患者におけるボグリボースの先発医薬品(ベイスン)と後発医薬品(ボグリダーゼ)の臨床的評価査読有り

小原拓, 高橋將喜, 高橋則男, 高橋武, 小林寛子, 猪狩有紀恵, 菊池大輔, 村井華代, 田中宏治, 大久保孝義, 齋藤真一郎, 今井潤

ジェネリック研究　1　(2)　85-91　2007年12月
出版者・発行元：日本ジェネリック医薬品・バイオシミラー学会
ISSN：1881-9117
Evaluation of efficacy and safety of manidipine hydrochloride among essential hypertensive patients - Substitution from branded product (Calslot (R)) to generic product (Manidip (R)) 査読有り

Hiroko Kobayashi, Taku Obara, Norio Takahashi, Takeshi Takahashi, Yukie Igari, Takuya Oikawa, Shinichiro Saito, Takayoshi Ohkubo, Yutaka Imai, Masanobu Takahashi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　127　(12)　2045-2050　2007年12月

ISSN：0031-6903
Incorporating self-blood pressure measurements at home in the guideline from the Ohasama study 査読有り

Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Azusa Hara, Ryusuke Inoue, Taku Obara, Takuo Hirose, Rieko Hatanaka, Atsushi Hozawa, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

BLOOD PRESSURE MONITORING　12　(6)　407-409　2007年12月

DOI： 10.1097/MBP.0b013e328244e8a7 　

ISSN：1359-5237
Factors affecting heart rate as measured at home among treated hypertensive patients: The Japan Home versus Office blood pressure Measurement Evaluation (J-HOME) study 査読有り

Rie Komai, Taku Obara, Takayoshi Ohkubo, Tetsuo Kato, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Azusa Hara, Koji Tanaka, Kenta Gonokami, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

HYPERTENSION RESEARCH　30　(11)　1051-1057　2007年11月

ISSN：0916-9636
本邦の高血圧治療にJSH2004が与えた影響 J-HOME研究

小原拓, 大久保孝義, 加藤哲夫, 田中宏治, 浅山敬, 菊谷昌浩, 目時弘仁, 井上隆輔, 原梓, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　153-153　2007年10月
出版者・発行元： (NPO)日本高血圧学会
日本人のメタボリックシンドローム診断における家庭血圧の有用性ならびにウエスト周囲径基準値についての検討大迫研究

佐藤敦, 浅山敬, 大久保孝義, 菊谷昌浩, 小原拓, 目時弘仁, 井上隆輔, 原梓, 原晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　154-154　2007年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧による各血圧因子の持つ脳卒中発症予測能の比較大迫研究

井上隆輔, 大久保孝義, 菊谷昌浩, 浅山敬, 目時弘仁, 小原拓, 廣瀬卓男, 原梓, 森戸里衣子, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 根東義明, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　176-176　2007年10月
出版者・発行元： (NPO)日本高血圧学会
随時血圧・自由行動下血圧・家庭血圧頸動脈病変と最も強く関連しているのはどれか? 大迫研究

田中一翔, 原梓, 大久保孝義, 菊谷昌浩, 目時弘仁, 小原拓, 大谷陽範, 井上隆輔, 浅山敬, 森戸里衣子, 廣瀬卓男, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　180-180　2007年10月
出版者・発行元： (NPO)日本高血圧学会
降圧治療中患者において家庭血圧測定より得られた血圧日間変動の規定因子

加藤哲夫, 菊谷昌浩, 小原拓, 大久保孝義, 原梓, 目時弘仁, 井上隆輔, 浅山敬, 廣瀬卓男, 森戸里衣子, 田中宏治, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　237-237　2007年10月
出版者・発行元： (NPO)日本高血圧学会
若年女性における月経周期と家庭血圧・脈拍との関連

目時弘仁, 渡邉悠美子, 西村美里, 大久保孝義, 菊谷昌浩, 森戸里衣子, 原梓, 廣瀬卓男, 田村知子, 小原拓, 菅野厚博, 浅山敬, 井上隆輔, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　238-238　2007年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧測定経験の有無と降圧治療 J-HOME研究より

小原拓, 大久保孝義, 浅山敬, 菊谷昌浩, 目時弘仁, 井上隆輔, 加藤哲夫, 田中宏治, 原梓, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　250-250　2007年10月
出版者・発行元： (NPO)日本高血圧学会
自由行動下血圧による血圧短期変動と家庭血圧による血圧日間変動大迫研究

菊谷昌浩, 大久保孝義, 目時弘仁, 浅山敬, 原梓, 小原拓, 井上隆輔, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　251-251　2007年10月
出版者・発行元： (NPO)日本高血圧学会
白衣高血圧・仮面高血圧における高感度C反応性蛋白大迫研究

原梓, 大久保孝義, 菊谷昌浩, 目時弘仁, 小原拓, 大谷陽範, 田中一翔, 井上隆輔, 浅山敬, 森戸里衣子, 廣瀬卓男, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　264-264　2007年10月
出版者・発行元： (NPO)日本高血圧学会
正常高値血圧のリスク評価と、高血圧治療ガイドラインへの家庭血圧導入の有用性大迫研究

浅山敬, 大久保孝義, 佐藤敦, 菊谷昌浩, 目時弘仁, 井上隆輔, 小原拓, 原梓, 廣瀬卓男, 森戸里衣子, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　270-270　2007年10月
出版者・発行元： (NPO)日本高血圧学会
腎機能障害と無症候性脳血管障害との関連大迫研究

大谷陽範, 原梓, 大久保孝義, 菊谷昌浩, 近藤健男, 小原拓, 目時弘仁, 井上隆輔, 浅山敬, 菅野厚博, 森戸里衣子, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 出江伸一, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　277-277　2007年10月
出版者・発行元： (NPO)日本高血圧学会
本邦における家庭血圧測定の現状医師、薬剤師、患者における実践と意識

田中宏治, 小原拓, 大久保孝義, 菊谷昌浩, 目時弘仁, 浅山敬, 橋本潤一郎, 戸恒和人, 真野少, 生出泉太郎, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　278-278　2007年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧測定に基づくフェノフィブラートの降圧効果査読有り

石川智史, 小原拓, 片岡裕貴, 花澤智大, 田中宏治, 芝宮拓, 森戸里衣子, 浅山敬, 菊谷昌浩, 大久保孝義, 戸恒和人, 橋本潤一郎, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　282-282　2007年10月
出版者・発行元： (NPO)日本高血圧学会
Control of home heart rate and home blood pressure levels in treated patients with hypertension: the J-HOME study 査読有り

Taku Obara, Takayoshi Ohkubo, Rie Komai, Kei Asayama, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Kayo Murai, Koji Tanaka, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

BLOOD PRESSURE MONITORING　12　(5)　289-295　2007年10月

ISSN：1359-5237
早朝高血圧患者におけるオルメサルタンとアムロジピンの薬効比較

佐藤茜, 小原拓, 大久保孝義, 井上奈緒, 目時弘仁, 井上隆輔, 浅山敬, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 今井潤

臨床高血圧　13　(3)　199-207　2007年9月
出版者・発行元： (株)メディカルレビュー社
ISSN：1342-2154
家庭血圧測定に基づくフェノフィブラートの降圧効果評価査読有り

石川智史, 小原拓, 片岡裕貴, 花澤智大, 田中宏治, 芝宮拓, 森戸里衣子, 浅山敬, 菊谷昌浩, 大久保孝義, 戸恒和人, 橋本潤一郎, 今井潤

Therapeutic Research　28　(9)　1853-1862　2007年9月
出版者・発行元：ライフサイエンス出版(株)
ISSN：0289-8020
Ambulatory blood pressure, blood pressure variability and the prevalence of carotid artery alteration: the Ohasama study 査読有り

Yoriko Shintani, Masahiro Kikuya, Azusa Hara, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Yoko Aono, Takanao Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

JOURNAL OF HYPERTENSION　25　(8)　1704-1710　2007年8月

ISSN：0263-6352
Reproducibility of nocturnal blood pressure assessed by self-measurement of blood pressure at home 査読有り

Keiko Hosohata, Masahiro Kikuya, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

HYPERTENSION RESEARCH　30　(8)　707-712　2007年8月

ISSN：0916-9636
Out-of-office blood pressure control among treated subjects 査読有り

Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Yutaka Imai

HYPERTENSION　49　(6)　E40-E41　2007年6月

DOI： 10.1161/HYPERTENSIONAHA.107.090993 　

ISSN：0194-911X
家庭血圧にもとづく選択的AT1受容体拮抗薬オルメサルタンの臨床的評価

井上奈緒, 小原拓, 大久保孝義, 佐藤茜, 中川美和, 橋本貴尚, 皆川加奈, 渡邉悠美子, 目時弘仁, 井上隆輔, 浅山敬, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 今井潤

血圧　14　(2)　205-212　2007年2月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
ACE阻害薬塩酸イミダプリルの早朝家庭血圧に及ぼす影響

芝崎貴子, 小原拓, 大久保孝義, 目時弘仁, 菊谷昌浩, 浅山敬, 橋本潤一郎, 戸恒和人, 今井潤

血圧　14　(1)　99-104　2007年1月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
29-A3-10-2 家庭血圧測定に基づくフェノフィブラートの降圧効果(薬剤疫学・医薬品情報,社会の期待に応える医療薬学を) 査読有り

石川智史, 大久保孝義, 戸恒和人, 橋本潤一郎, 今井潤, 小原拓, 片岡裕貴, 花澤智大, 田中宏治, 芝宮拓, 森戸里衣子, 浅山敬, 菊谷昌浩

日本医療薬学会年会講演要旨集　17　(0)　188-188　2007年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.17.0_188_2 　
Blood pressure lowering effect of fenofibrate evaluated by home blood pressure 査読有り

Tomofumi Ishikawa, Taku Obara, Hiroki Kataoka, Tomohiro Hanazawa, Koji Tanaka, Taku Shibamiya, Rieko H. Morito, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Kazuhito Totsune, Junichiro Hashimoto, Yutaka Imai

Therapeutic Research　28　(9)　1853-1862　2007年

ISSN：0289-8020
Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study: Status at February 2004 査読有り

Keiko Hosohata, Shin Saito, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Taku Obara, Tetsuo Kato, Junichiro Hashimoto, Kazuhito Totsune, Yukio Miura, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　29　(1)　69-81　2007年1月

DOI： 10.1080/10641960601096976 　

ISSN：1064-1963
Current usage of diuretics among hypertensive patients in Japan: The Japan home versus office blood pressure measurement evaluation (J-HOME) study 査読有り

Kayo Murai, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Takuya Oikawa, Ryusuke Inoue, Rie Komai, Tsuyoshi Horikawa, Kei Asayama, Masahiro Kikuya, Kazuhito Totsune, Junichiro Hashimoto, Yutaka Imai

HYPERTENSION RESEARCH　29　(11)　857-863　2006年11月

ISSN：0916-9636
家庭血圧測定経験の有無と降圧治療 J-HOME研究より

小原拓, 大久保孝義, 浅山敬, 目時弘仁, 井上隆輔, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 今井潤

血圧　13　(10)　1128-1129　2006年10月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
家庭血圧に基づいた高血圧管理ガイドラインの有用性大迫研究

浅山敬, 大久保孝義, 小原拓, 菊谷昌浩, 目時弘仁, 井上隆輔, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

血圧　13　(10)　1130-1131　2006年10月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
高校生における血圧値および高血圧基準値の認識に関する調査成績(05')

小原拓, 大久保孝義, 目時弘仁, 井上隆輔, 浅山敬, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 今井潤

Health Sciences　22　(4)　576-576　2006年10月
出版者・発行元： (一社)日本健康科学学会
ISSN：0911-7024
The economic impact of the introduction of home blood pressure measurement for the diagnosis and treatment of hypertension 査読有り

Jin Funahashi, Takayoshi Ohkubo, Hidefumi Fukunaga, Masahiro Kikuya, Noriko Takada, Kei Asayama, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Junichiro Hashimoto, Kazuhito Totsune, Makoto Kobayashi, Yutaka Imai

BLOOD PRESSURE MONITORING　11　(5)　257-267　2006年10月

ISSN：1359-5237
Prediction of stroke by home "morning" versus "evening" blood pressure values - The Ohasama study 査読有り

Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Azusa Hara, Takuo Hirose, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

HYPERTENSION　48　(4)　737-743　2006年10月

DOI： 10.1161/01.HYP.0000240332.01877.11 　

ISSN：0194-911X
Characteristics of resistant hypertension determined by self-measured blood pressure at home and office blood pressure measurements: the J-HOME study 査読有り

Takuya Oikawa, Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Rie Komai, Kayo Murai, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

JOURNAL OF HYPERTENSION　24　(9)　1737-1743　2006年9月

ISSN：0263-6352
The current status of home and office blood pressure control among hypertensive patients with diabetes mellitus: The Japan Home Versus Office Blood Pressure Measurement Evaluation (J-HOME) study 査読有り

Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Ryusuke Inoue, Takuya Oikawa, Kayo Murai, Rie Komai, Tsuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

DIABETES RESEARCH AND CLINICAL PRACTICE　73　(3)　276-283　2006年9月

DOI： 10.1016/j.diabres.2006.01.015 　

ISSN：0168-8227
[Practical use of self-measured blood pressure at home]. 査読有り

Obara T, Imai Y, Asayama K

Nihon rinsho. Japanese journal of clinical medicine　64 Suppl 6　5-9　2006年8月

ISSN：0047-1852
わが国における家庭血圧測定の現状外来患者8,506人の実践と意識"家庭血圧測定の現状に関する調査研究"

小原拓, 大久保孝義, 菊谷昌浩, 福永英史, 村井華代, 浅山敬, 目時弘仁, 橋本潤一郎, 戸恒和人, 今井潤

血圧　13　(4)　447-454　2006年4月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
本邦における利尿薬使用の現状

村井華代, 小原拓, 大久保孝義, 及川卓也, 駒井理恵, 堀川剛, 菊谷昌浩, 浅山敬, 井上隆輔, 目時弘仁, 戸恒和人, 橋本潤一郎, 今井潤

日本薬学会年会要旨集　126年会　(2)　155-155　2006年3月
出版者・発行元： (公社)日本薬学会
ISSN：0918-9823
わが国における家庭血圧測定の現状医師1,928人の実践と意識"家庭血圧測定の現状に関する調査研究"

福永英史, 大久保孝義, 小原拓, 菊谷昌浩, 浅山敬, 目時弘仁, 橋本潤一郎, 戸恒和人, 今井潤

血圧　13　(1)　122-128　2006年1月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
Prevalence of masked uncontrolled and treated white-coat hypertension defined according to the average of morning and evening home blood pressure value: from the Japan Home versus Office Measurement Evaluation Study 査読有り

T Obara, T Ohkubo, M Kikuya, K Asayama, H Metoki, R Inoue, T Oikawa, R Komai, K Murai, T Horikawa, J Hashimoto, K Totsune, Y Imai

BLOOD PRESSURE MONITORING　10　(6)　311-316　2005年12月

ISSN：1359-5237
血漿フィブリノーゲン値と無症候性脳血管障害との関連大迫研究

青野蓉子, 菊谷昌浩, 原梓, 大久保孝義, 近藤健男, 浅山敬, 井上隆輔, 目時弘仁, 小原拓, 新谷依子, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 出江伸一, 今井潤

日本循環器病予防学会誌　40　(3)　181-189　2005年10月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
Use of 2003 European Society of Hypertension-European Society of Cardiology guidelines for predicting stroke using self-measured blood pressure at home: the Ohasama study 査読有り

K Asayama, T Ohkubo, M Kikuya, H Metoki, T Obara, H Hoshi, J Hashimoto, K Totsune, H Satoh, Y Imai

EUROPEAN HEART JOURNAL　26　(19)　2026-2031　2005年10月

DOI： 10.1093/eurheartj/ehi330 　

ISSN：0195-668X
電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP Study)中間報告:2005年2月末における割付け状況および家庭血圧値の推移,HOMED-BP研究グループを代表して

大久保孝義, 浅山敬, 小原拓, 目時弘仁, 齊藤伸, 細畑圭子, 橋本潤一郎, 戸恒和人, 三浦幸雄, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　21-21　2005年9月
出版者・発行元： (NPO)日本高血圧学会
朝晩の家庭血圧測定値の臨床的有用性脳卒中発症予測能の観点から大迫研究

浅山敬, 大久保孝義, 小原拓, 菊谷昌浩, 目時弘仁, 井上隆輔, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　32-32　2005年9月
出版者・発行元： (NPO)日本高血圧学会
24時間自由行動下血圧測定から得られる4つの血圧因子(収縮期血圧,拡張期血圧,平均血圧および脈圧)の脳卒中発症予測能

井上隆輔, 大久保孝義, 菊谷昌浩, 浅山敬, 目時弘仁, 小原拓, 橋本潤一郎, 戸恒和人, 星晴久, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　64-64　2005年9月
出版者・発行元： (NPO)日本高血圧学会
白衣高血圧・仮面高血圧の頸動脈病変:大迫研究

原梓, 大久保孝義, 菊谷昌浩, 小原拓, 目時弘仁, 井上隆輔, 浅山敬, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　69-69　2005年9月
出版者・発行元： (NPO)日本高血圧学会
一包化調剤対応服薬コンプライアンス計の開発と臨床応用

今井潤, 大久保孝義, 小原拓, 菊谷昌宏, 浅山敬, 目時弘仁, 橋本潤一郎, 戸恒和人

日本高血圧学会総会プログラム・抄録集　28回　163-163　2005年9月
出版者・発行元： (NPO)日本高血圧学会
異なる病型の脳卒中発症に対する一日の各時間帯における血圧のリスクの比較検討大迫研究

目時弘仁, 大久保孝義, 菊谷昌浩, 浅山敬, 小原拓, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　175-175　2005年9月
出版者・発行元： (NPO)日本高血圧学会
自由行動下血圧測定による血圧短期変動および心拍短期変動の脳卒中予後予測能大迫研究

菊谷昌浩, 大久保孝義, 浅山敬, 目時弘仁, 井上隆輔, 小原拓, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　182-182　2005年9月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧における治療抵抗性高血圧の要因に関する検討 J-HOME研究

及川卓也, 小原拓, 大久保孝義, 菊谷昌浩, 浅山敬, 目時弘仁, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　183-183　2005年9月
出版者・発行元： (NPO)日本高血圧学会
本邦における家庭血圧測定の現状-2 一般市民の実践と意識

大久保孝義, 小原拓, 菊谷昌宏, 浅山敬, 目時弘仁, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　202-202　2005年9月
出版者・発行元： (NPO)日本高血圧学会
本邦における家庭血圧測定の現状-1 医師1704人の実践と意識"家庭血圧測定の現状に関する調査研究"協力者を代表して

今井潤, 大久保孝義, 小原拓, 菊谷昌宏, 浅山敬, 目時弘仁, 橋本潤一郎, 戸恒和人

日本高血圧学会総会プログラム・抄録集　28回　204-204　2005年9月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧による夜間血圧,夜間血圧降下度の評価大迫研究

細畑圭子, 菊谷昌浩, 大久保孝義, 浅山敬, 目時弘仁, 小原拓, 井上隆輔, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　205-205　2005年9月
出版者・発行元： (NPO)日本高血圧学会
日本全国の降圧治療中の本態性高血圧患者における早朝家庭血圧および就寝前家庭血圧管理状況 J-HOME研究グループを代表して

小原拓, 大久保孝義, 舟橋仁, 及川卓也, 菊谷昌宏, 浅山敬, 目時弘仁, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　28回　207-207　2005年9月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧による血圧日間変動の脳卒中予測能

菊谷昌浩, 大久保孝義, 浅山敬, 目時弘仁, 小原拓, 井上隆輔, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

血圧　12　(9)　990-991　2005年9月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
Isolated uncontrolled hypertension at home and in the office among treated hypertensive patients from the J-HOME study 査読有り

T Obara, T Ohkubo, J Funahashi, M Kikuya, K Asayama, H Metoki, T Oikawa, J Hashimoto, K Totsune, Y Imai

JOURNAL OF HYPERTENSION　23　(9)　1653-1660　2005年9月

ISSN：0263-6352
White-coat hypertension as a risk factor for the development of home hypertension: The Ohasama study 査読有り

Takashi Ugajin, Atsushi Hozawa, Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Ichiro Tsuji, Yutaka Imai

Archives of Internal Medicine　165　(13)　1541-1546　2005年7月11日

DOI： 10.1001/archinte.165.13.1541 　

ISSN：0003-9926
【管理不良高血圧/治療抵抗性高血圧へのアプローチ】対策真の管理不良高血圧例と白衣性管理不良高血圧例とをどう鑑別するか,どう対応すればよいか

渡部大介, 橋本潤一郎, 小原拓, 今井潤

Modern Physician　25　(2)　159-162　2005年2月
出版者・発行元： (株)新興医学出版社
ISSN：0913-7963
インターネットを介した家庭血圧にもとづく降圧療法に関する大規模介入試験(HOMED-BP研究)中間報告 2004年2月末における割付け状況と血圧推移

齊藤伸, 細畑圭子, 浅山敬, 大久保孝義, 菊谷昌浩, 目時弘仁, 小原拓, 橋本潤一郎, 戸恒和人, 三浦幸雄, 今井潤, HOMED-BP研究グループ

血圧　12　(1)　127-135　2005年1月
出版者・発行元： (株)先端医学社
ISSN：1340-4598
Prediction of ischaemic and haemorrhagic stroke by self-measured blood pressure at home: the Ohasama study 査読有り

T Ohkubo, K Asayama, M Kikuya, H Metoki, T Obara, S Saito, H Hoshi, J Hashimoto, K Totsune, H Satoh, Y Imai

BLOOD PRESSURE MONITORING　9　(6)　315-320　2004年12月

ISSN：1359-5237
電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP)研究 2004年2月末における現状報告および低値群降圧目標未達成の要因分析

齊藤伸, 細畑圭子, 浅山敬, 大久保孝義, 菊谷昌浩, 小原拓, 目時弘仁, 橋本潤一郎, 三浦幸雄, 今井潤

日本高血圧学会総会プログラム・抄録集　27回　16-16　2004年10月
出版者・発行元： (NPO)日本高血圧学会
糖尿病合併高血圧患者における家庭血圧および外来血圧管理状況

小原拓, 大久保孝義, 舟橋仁, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　27回　147-147　2004年10月
出版者・発行元： (NPO)日本高血圧学会
The second progress report on the Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study 査読有り

S Saito, K Asayama, T Ohkubo, M Kikuya, H Metoki, T Obara, J Hashimoto, K Totsune, M Yukio, Y Imai

BLOOD PRESSURE MONITORING　9　(5)　243-247　2004年10月

ISSN：1359-5237
Control of blood pressure as measured at home and office, and comparison with physicians' assessment of control among treated hypertensive patients in Japan: First report of the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study 査読有り

T Ohkubo, T Obara, J Funahashi, M Kikuya, K Asayama, H Metoki, T Oikawa, H Takahashi, J Hashimoto, K Totsune, Y Imai

HYPERTENSION RESEARCH　27　(10)　755-763　2004年10月

ISSN：0916-9636
高校生における高血圧/正常血圧基準値の認識に関する調査成績

小原拓, 木村淳史, 齊藤伸, 高田紀子, 舟橋仁, 浅山敬, 宇賀神卓嗣, 佐藤ともみ, 中村洋介, 村松靖子, 高橋久樹, 原梓, 原澤俊也, 広瀬卓男, 渡部大介, 目時弘仁, 菊谷昌浩, 大久保孝義, 橋本潤一郎, 戸恒和人, 今井潤

保健の科学　46　(8)　623-629　2004年8月
出版者・発行元： (株)杏林書院
ISSN：0018-3342
家庭血圧コントロール状況に関する全国調査研究第一次報告:対象者の特性および主治医による家庭血圧値の評価「家庭血圧コントロール状況に関する全国調査研究グループ」を代表して

大久保孝義, 菊谷昌浩, 小原拓, 舟橋仁, 橋本潤一郎, 今井潤

日本高血圧学会総会プログラム・抄録集　26回　51-51　2003年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧コントロール状況に関する全国調査研究(J-HOME研究)中間報告 2003年4月末における対象患者1533人の家庭血圧状況

大久保孝義, 小原拓, 舟橋仁, 菊谷昌浩, 橋本潤一郎, 今井潤

Therapeutic Research　24　(9)　1849-1855　2003年9月
出版者・発行元：ライフサイエンス出版(株)
ISSN：0289-8020
Trisomy 18 mosaicism associated with secondary amenorrhea: Ratios of mosaicism in different samples and complications 査読有り

S. Uehara, Y. Obara, T. Obara, T. Funato, N. Yaegashi, T. Fukaya, A. Yajima

Clinical Genetics　49　(2)　91-94　1996年2月

ISSN：0009-9163

︎全件表示 ︎最初の5件までを表示

MISC 313

血圧コントロール不良に対する不十分な高血圧薬物治療による影響リアルワールドデータに基づく解析

佐藤倫広, 室谷智子, 村上任尚, 小原拓, 浅山敬, 大久保孝義, 今井潤, 目時弘仁

日本循環器病予防学会誌　58　(2)　146-146　2023年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
収縮期・拡張期血圧を用いた詳細血圧分類と慢性腎臓病発症リスクの関連

末永司, 佐藤倫広, 村上任尚, 廣瀬卓男, 中山晋吾, 小原拓, 森建文, 今井潤, 大久保孝義, 目時弘仁

日本循環器病予防学会誌　58　(2)　157-157　2023年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
東北メディカル・メガバンク計画三世代コホート調査の進捗と今後の計画

石黒真美, 小原拓, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 目時弘仁, 菊谷昌浩, 菅原準一, 中谷直樹, 寳澤篤, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　117-117　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
大規模観察研究におけるランダム男女ペア間の循環代謝リスク因子の類似性の検討

中谷直樹, 中谷久美, 土屋菜歩, 曽根稔雅, 小暮真奈, 畑中里衣子, 菅野郁美, 目時弘仁, 小原拓, 石黒真美, 寳澤篤, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　173-173　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
TERATOGENIC RISK OF FIRST TRIMESTER EXPOSURE TO ANTIHYPERTENSIVES, INCLUDING AMLODIPINE AND METHYLDOPA: AN ANALYSIS OF AN ADMINISTRATIVE DATABASE 2010-2019

Tomofumi Ishikawa, Hidekazu Nishigori, Manabu Akazawa, Keiko Miyakoda, Aoi Noda, Mami Ishikuro, Hirohito Metoki, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

JOURNAL OF HYPERTENSION　41　E422-E422　2023年1月

ISSN： 0263-6352

eISSN： 1473-5598
正常高値血圧、高値血圧における中心血圧、頸動脈内膜中膜厚と新規高血圧発症の関連

時岡紗由理, 中谷直樹, 中谷久美, 高瀬雅仁, 小暮真奈, 畑中里衣子, 菅野郁美, 千葉一平, 目時弘仁, 村上任尚, 佐藤倫広, 小原拓, 栗山進一, 寳澤篤

日本高血圧学会総会プログラム・抄録集　44回　80-80　2022年10月
出版者・発行元： (NPO)日本高血圧学会
赤ちゃんに対する気持ち質問票を用いた、母親の乳児へのマルトリートメントに対するスクリーニングの有用性

森美由紀, 西郡俊絵, 小原拓, 櫻井香澄, 鈴木妙子, 石黒真美, 龍田希, 齋藤昌利, 菅原準一, 有馬隆博, 仲井邦彦, 目時弘仁, 栗山進一, 八重樫伸生, 西郡秀和

日本周産期メンタルヘルス学会学術集会抄録集　18回　54-54　2022年10月
出版者・発行元：日本周産期メンタルヘルス学会
年齢と骨梁面積率との関連年齢階級別の検討 ToMMo地域住民コホート調査

菅野郁美, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 中村智洋, 小原拓, 目時弘仁, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　203-203　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
心血管・代謝疾患リスク要因における配偶者同士の類似性 2ヵ国バイオバンク横断研究

中谷直樹, 土屋菜歩, 成田暁, 中村智洋, 目時弘仁, 小原拓, 石黒真美, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　81回　204-204　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
妊娠中の社会的孤立と産後ボンディング障害の関連三世代コホート調査

村上慶子, 小原拓, 目時弘仁, 栗山進一

日本公衆衛生学会総会抄録集　81回　330-330　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 寳澤篤

東北公衆衛生学会誌　(71)　28-28　2022年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
母子保健情報と学校保健情報を連係した情報の活用に向けた研究三世代コホートにおける情報収集の推進

栗山進一, 小原拓, 松崎芙実子, 大沼ともみ, 野田あおい, 上野史彦, 村上慶子, 石黒真美, 小林雅幸

母子保健情報と学校保健情報を連係した情報の活用に向けた研究令和3年度総括・分担研究年度終了報告書(Web)　2022年
母子保健情報と学校保健情報を連係した情報の活用に向けた研究学童期の疾患の発症と予後に関する検討・解析(幼児期の肥満における関連要因の検討)

菅原準一, 菅原準一, 小原拓, 松崎芙実子, 大沼ともみ, 野田あおい, 上野史彦, 村上慶子, 石黒真美, 小林雅幸

母子保健情報と学校保健情報を連係した情報の活用に向けた研究令和3年度総括・分担研究年度終了報告書(Web)　2022年
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　80回　219-219　2021年11月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
レセプトデータを用いた若年女性がん患者の抗がん薬治療実態の把握

土屋雅美, 土屋雅美, 田島健太郎, 小原拓, 小原拓, 眞野成康, 眞野成康

日本臨床腫瘍学会学術集会(CD-ROM)　18th　2021年
【「今さら聞けない」をスッキリ解消する妊娠・授乳と薬】[授乳と薬]授乳婦への服薬指導のポイントと注意点

小原拓

薬事　62　(4)　761-765　2020年3月
出版者・発行元： (株)じほう
ISSN： 0016-5980
Bootstrap法およびPermutation法の応用による三世代家族の身長,体重,BMIの世代間関連の評価:三世代コホート調査

臼崎琢磨, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 野田あおい, 野田あおい, 野田あおい, 上野史彦, 上野史彦, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

日本衛生学雑誌(Web)　75　(Supplement)　2020年

ISSN： 1882-6482
妊婦における妊娠前からの葉酸サプリメントの摂取率および関連要因の検討:三世代コホート研究

菊池大輔, 臼崎琢磨, 大柳元, 大柳元, 米沢祐大, 米沢祐大, 山下貴宏, 山下貴宏, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 小原拓, 小原拓

日本疫学会学術総会講演集(Web)　30th　2020年
【Evidence Update 2020 最新の薬物治療のエビデンスを付加的に利用する】エキスパートが注目する最新エビデンスをアップデート! 降圧薬

菊池大輔, 三浦良祐, 小原拓

薬局　71　(1)　22-26　2020年1月
出版者・発行元： (株)南山堂
ISSN： 0044-0035
Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. 国際誌査読有り

Takumi Hirata, Tomohiro Nakamura, Mana Kogure, Naho Tsuchiya, Akira Narita, Ken Miyagawa, Kotaro Nochioka, Akira Uruno, Taku Obara, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　23-29　2020年1月

DOI： 10.1038/s41440-019-0329-0 　

ISSN： 0916-9636
Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. 国際誌査読有り

Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　62-71　2020年1月

DOI： 10.1038/s41440-019-0335-2 　

ISSN： 0916-9636
大規模健診時血圧データに基づく加齢に伴う血圧推移に関する縦断解析

佐藤倫広, 村上任尚, 小原拓, 辰巳友佳子, 高畠恭介, 原梓, 浅山敬, 今井潤, 菊谷昌浩, 大久保孝義, 目時弘仁

日本循環器病予防学会誌　54　(3)　163-170　2019年12月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

寳澤篤, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 布施昇男, 山本雅之

日本公衆衛生学会総会抄録集　78回　212-212　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
6.3万人データ分譲に向けて東北メディカル・メガバンク計画地域住民コホート調査

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 村上慶子, 小原拓, 中谷直樹, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　78回　212-212　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討東北メディカル・メガバンク計画コホート調査の成果から

小暮真奈, 平田匠, 土屋菜歩, 中村智洋, 宮川健, 小清水宏, 小原拓, 目時弘仁, 宇留野晃, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　287-287　2019年10月
出版者・発行元： (NPO)日本高血圧学会
非喫煙者における受動喫煙の有無と家庭高血圧の関連

平田匠, 小暮真奈, 成田暁, 佐藤倫広, 土屋菜歩, 中村智洋, 宇留野晃, 小原拓, 目時弘仁, 中谷直樹, 菅原準一, 栗山進一, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　288-288　2019年10月
出版者・発行元： (NPO)日本高血圧学会
本態性高血圧患者における治療前および降圧治療中の家庭血圧指標の予後予測能 HOMED-BP研究

渡部大介, 浅山敬, 花澤智大, 保坂実樹, 佐藤倫広, 安井大策, 小原拓, 井上隆輔, 目時弘仁, 菊谷昌浩, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　42回　223-223　2019年10月
出版者・発行元： (NPO)日本高血圧学会
【高血圧地域包括ケアで薬立つ血圧管理の勘所】高血圧対応力を磨く10のClinical Question! 薬局での血圧測定の意義は何か

小原拓

薬局　70　(10)　1919-1923　2019年9月
出版者・発行元： (株)南山堂
ISSN： 0044-0035
【高血圧地域包括ケアで薬立つ血圧管理の勘所】高血圧の薬学的管理Clinical Evidence Synopsis 先行研究から明らかとなった薬剤師による介入の有効性

石黒真美, 小原拓

薬局　70　(10)　1955-1962　2019年9月
出版者・発行元： (株)南山堂
ISSN： 0044-0035
選ばれる薬局を目指して

川田哲, 小原拓, 阿部真也, 齋藤真奈実, 川田むつき, 佐藤宏平, 野村和彦, 吉町昌子, 後藤輝明

社会薬学　38　(Suppl.)　88-88　2019年9月
出版者・発行元：日本社会薬学会
ISSN： 0911-0585

eISSN： 2188-2754
Lenalidomide使用中の多発性骨髄腫患者におけるacetylsalicylic acidの使用状況 MDV analyzerを用いた診療データに基づく実態調査

菊池大輔, 小原拓, 三浦良祐, 高橋庄太, 柏倉正太, 岡田浩司, 渡辺善照

医薬品情報学　21　(2)　79-86　2019年8月
出版者・発行元： (一社)日本医薬品情報学会
ISSN： 1345-1464

eISSN： 1883-423X
生活者からの質問相談内容から作成したOTC販売時の医薬品リスト利用状況調査

玉田麻利子, 阿部真也, 小原拓, 武藤一敬, 野村和彦, 吉町昌子, 後藤輝明

日本医薬品情報学会総会・学術大会講演要旨集　22回　104-104　2019年6月
出版者・発行元： (一社)日本医薬品情報学会
妊婦の推定糸球体ろ過量(eGFR)と妊娠高血圧症候群の関連について BOSHI研究

菊地ひかり, 奈良井大輝, 佐々木里美, 高畠恭介, 中山晋吾, 佐藤倫広, 村上任尚, 岩間憲之, 石黒真美, 小原拓, 大久保孝義, 今井潤, 目時弘仁

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　8回　198-198　2019年5月
出版者・発行元： (NPO)日本高血圧学会
妊婦の推定糸球体ろ過量(eGFR)と妊娠高血圧症候群の関連について BOSHI研究

菊地ひかり, 奈良井大輝, 佐々木里美, 高畠恭介, 中山晋吾, 佐藤倫広, 村上任尚, 岩間憲之, 石黒真美, 小原拓, 大久保孝義, 今井潤, 目時弘仁

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　8回　198-198　2019年5月
出版者・発行元： (NPO)日本高血圧学会
新規リスク因子(尿ナトカリ比高値・睡眠効率不良)の高血圧への集団寄与危険割合の検討

平田匠, 中村智洋, 小暮真奈, 宮川健, 小原拓, 中谷直樹, 宇留野晃, 菅原準一, 栗山進一, 寳澤篤

日本循環器病予防学会誌　54　(2)　121-121　2019年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
成人における客観的睡眠効率と高血圧有病率との関連(Association of Objective Sleep Efficiency with Prevalence of Hypertension in Adults)

平田匠, 中村智洋, 小暮真奈, 成田暁, 宮川健, 後岡広太郎, 土屋菜歩, 小原拓, 中谷直樹, 栗山進一, 寳澤篤

日本循環器学会学術集会抄録集　83回　OJ22-4　2019年3月
出版者・発行元： (一社)日本循環器学会
JADERを用いた小児におけるシグナル検出の妥当性の検討

酒井隆全, 小原拓, 吉田真貴子, 田辺公一, 大津史子

日本薬学会年会要旨集　139年会　(4)　177-177　2019年3月
出版者・発行元： (公社)日本薬学会
ISSN： 0918-9823
我が国の小児を対象とした大規模バイオバンクとコホート研究東北メディカル・メガバンクの三世代コホート調査の概要と収集試料・データの利活用

栗山進一, 小原拓, 石黒真美, 呉繁夫

日本小児科学会雑誌　123　(2)　159-159　2019年2月
出版者・発行元： (公社)日本小児科学会
ISSN： 0001-6543
配偶者の主観的健康観と自身の抑うつ症状との関連:東北メディカル・メガバンク計画・地域住民コホート調査

中谷直樹, 土屋菜歩, 中谷久美, 成田暁, 平田匠, 中村智洋, 小暮真奈, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　122 (WEB ONLY)　2019年1月30日
Antihypertensives Prescribed for Pregnant Women in Japan: Prevalence and Timing Determined from a Database of Health Insurance Claims

Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Keiko Miyakoda, Mami Ishikuro, Hirohito Metoki, Takayoshi Ohkubo, Junichi Sugawara, Nobuo Yaegashi, Manabu Akazawa, Shinichi Kuriyama, Nariyasu Mano

Drug Safety　41　(11)　1168-1169　2018年11月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s40264-018-0719-2 　
妊娠期間中の飲酒と妊娠高血圧症候群リスクとの関連

岩間憲之, 田中宏典, 目時弘仁, 西郡秀和, 水野聖士, 高橋史郎, 渡邉善, 齋藤昌利, 櫻井香澄, 石黒真美, 小原拓, 龍田希, 西島維知子, 杉山隆, 藤原幾磨, 栗山進一, 有馬隆博, 仲井邦彦, 八重樫伸生

日本妊娠高血圧学会雑誌　25　109-109　2018年11月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
東日本大震災後のメンタルヘルス関連指標変化と家屋被害の関連

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 呉繁夫, 大塚耕太郎, 富田博秋, 寳澤篤

日本公衆衛生学会総会抄録集　77回　252-252　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
家屋の損壊の程度と頸動脈エコー内膜中膜肥厚の変化地域住民コホート調査

寳澤篤, 中谷久美, 平田匠, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 呉繁夫

日本公衆衛生学会総会抄録集　77回　345-345　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
一般住民における尿Na/K比と腎機能障害への進行の関連住民コホート調査

良知弘務, 土屋菜歩, 平田匠, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　345-345　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災の被災地住民における平均歩数の変化地域住民コホート調査

中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　209-209　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
尿中ナトリウムカリウム比値と家庭血圧値の変化地域住民コホート調査

小暮真奈, 中谷直樹, 土屋菜歩, 中村智洋, 平田匠, 成田暁, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　215-215　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災の被災地住民における家庭血圧値の変化地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　218-218　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
家屋損壊程度と骨梁面積率の変化量の関連東北メディカル・メガバンク事業

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　253-253　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災に伴う家屋被害の程度とHbA1c値の変化の関連地域住民コホート調査

平田匠, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　358-358　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
レセプトデータベースに基づく妊婦への降圧薬処方状況の評価

石川智史, 小原拓, 都田桂子, 石黒真美, 目時弘仁, 大久保孝義

日本高血圧学会総会プログラム・抄録集　41回　OE05-04　2018年9月
出版者・発行元： (NPO)日本高血圧学会
疫学研究における妊婦の随時血圧と家庭血圧に関する検討三世代コホート調査

臼崎琢磨, 石黒真美, 小原拓, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 菊谷昌浩, 目時弘仁, 栗山進一

日本高血圧学会総会プログラム・抄録集　41回　YIP-09　2018年9月
出版者・発行元： (NPO)日本高血圧学会
レセプトデータベースに基づく妊婦への降圧薬処方状況の評価

石川智史, 小原拓, 都田桂子, 石黒真美, 目時弘仁, 大久保孝義

日本高血圧学会総会プログラム・抄録集　41回　OE05-04　2018年9月
出版者・発行元： (NPO)日本高血圧学会
身長、体重、BMIの世代間の関連三世代コホート調査

臼崎琢磨, 石黒真美, 小原拓, 山中千鶴, 永井雅人, 松原博子, 菊谷昌浩, 目時弘仁, 栗山進一

東北公衆衛生学会誌　(67)　35-35　2018年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
Defined Daily Doseと比較した日本の降圧薬処方用量レセプトデータに基づく検討

佐藤倫広, 村上任尚, 小原拓, 辰巳友佳子, 高畠恭介, 原梓, 浅山敬, 今井潤, 大久保孝義, 目時弘仁

日本医薬品情報学会総会・学術大会講演要旨集　21回　125-125　2018年6月
出版者・発行元： (一社)日本医薬品情報学会
大規模健診時血圧データに基づくリアルワールドにおける降圧治療前後の血圧状況に関する前向き検討

佐藤倫広, 村上任尚, 小原拓, 辰巳友佳子, 原梓, 浅山敬, 今井潤, 大久保孝義, 目時弘仁

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　7回　218-218　2018年5月
出版者・発行元： (NPO)日本高血圧学会
大規模健診時血圧データに基づくリアルワールドにおける降圧治療前後の血圧状況に関する前向き検討

佐藤倫広, 村上任尚, 小原拓, 辰巳友佳子, 原梓, 浅山敬, 今井潤, 大久保孝義, 目時弘仁

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　7回　218-218　2018年5月
出版者・発行元： (NPO)日本高血圧学会
大規模健診時血圧データに基づく加齢に伴う健診時血圧の推移に関する検討

佐藤倫広, 村上任尚, 小原拓, 辰巳友佳子, 高畠恭介, 原梓, 浅山敬, 今井潤, 大久保孝義, 目時弘仁

日本循環器病予防学会誌　53　(2)　183-183　2018年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
レセプトデータを利用した小児ADHD患者における処方実態の把握

吉田真貴子, 小原拓, 菊地紗耶, 菊地正史, 山口浩明, 眞野成康

日本薬学会年会要旨集　138年会　(4)　185-185　2018年3月
出版者・発行元： (公社)日本薬学会
ISSN： 0918-9823
出生体重と成人期の高血圧有病との関連:東北メディカル・メガバンク計画地域住民コホート調査

石黒真美, 小原拓, 目時弘仁, 目時弘仁, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 菅原準一, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一

日本疫学会学術総会講演集(Web)　28th　118 (WEB ONLY)　2018年2月1日
周辺環境へのアクセシビリティと産後6ヶ月時点の抑うつ症状との関連:三世代コホート調査

永井雅人, 水野聖士, 小暮真奈, 石黒真美, 山中千鶴, 松原博子, 小原拓, 小原拓, 菊谷昌浩, 目時弘仁, 目時弘仁, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　28th　85 (WEB ONLY)　2018年2月1日
抗がん薬による手足症候群発現時期に関する検討

小林美奈子, 土屋雅美, 土屋雅美, 菊地正史, 小原拓, 木皿重樹, 高村千津子, 眞野成康, 眞野成康

日本臨床腫瘍薬学会学術大会講演要旨集　2018　2018年
降圧治療中患者におけるHome Arterial Stiffness Index(HASI)の臨床的有用性の評価

小原拓, 菊谷昌浩, 佐藤倫広, 井上隆輔, 浅山敬, 目時弘仁, 目時弘仁, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　40th　446-446　2017年10月20日
出版者・発行元： (NPO)日本高血圧学会
尿中ナトリウムカリウム比と高血圧有病リスクとの関連地域住民コホート調査

小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 清元秀泰, 菊谷昌浩, 目時弘仁, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　291-291　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
地域住民コホート調査における年齢別の中心血圧分布

菊谷昌浩, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 目時弘仁, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　293-293　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の被災地における降圧治療中患者の血圧管理東北メディカル・メガバンク地域住民コホート調査

小原拓, 菊谷昌浩, 石黒真美, 目時弘仁, 寳澤篤

日本高血圧学会総会プログラム・抄録集　40回　407-407　2017年10月
出版者・発行元： (NPO)日本高血圧学会
検診時血圧と家庭血圧の男女別年齢階級別平均値東北メディカル・メガバンク計画地域住民コホート調査

目時弘仁, 佐藤倫広, 村上任尚, 石黒真美, 小原拓, 菊谷昌浩, 清元秀泰, 寳澤篤

日本高血圧学会総会プログラム・抄録集　40回　411-411　2017年10月
出版者・発行元： (NPO)日本高血圧学会
妊婦に対する降圧薬処方の実態レセプトデータに基づく検討

小原拓, 目時弘仁, 佐藤倫広, 石黒真美, 菊谷昌浩, 大久保孝義

日本高血圧学会総会プログラム・抄録集　40回　413-413　2017年10月
出版者・発行元： (NPO)日本高血圧学会
受動喫煙と妊娠期間中の血圧推移 BOSHI研究

目時弘仁, 佐藤倫広, 村上任尚, 田中宏典, 石黒真美, 小原拓, 八重樫伸生, 星和彦, 今井潤, 大久保孝義

日本アルコール・薬物医学会雑誌　52　(4)　238-238　2017年8月
出版者・発行元： (一社)日本アルコール・アディクション医学会
ISSN： 1341-8963
東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

宮下真子, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 佐藤ゆき, 石黒真美, 小原拓, 目時弘仁, 栗山進一

東北公衆衛生学会誌　(66)　31-31　2017年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

宮下真子, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 佐藤ゆき, 石黒真美, 小原拓, 目時弘仁, 栗山進一

東北公衆衛生学会誌　(66)　31-31　2017年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
東日本大震災後の宮城県における小中学生の気管支喘息と湿疹の有症率について東北大学東北メディカル・メガバンク機構地域子ども長期健康調査より

宮下真子, 菊谷昌浩, 田中彰二, 山中千鶴, 佐藤ゆき, 水野聖士, 石黒真美, 小原拓, 目時弘仁, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 寳澤篤, 辻一郎, 栗山進一

宮城県公衆衛生学会会誌　(49)　14-14　2017年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク事業地域住民コホート(宮城県)の進捗とこれまでの成果で見えてきたこと

寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菊谷昌浩, 小原拓, 石黒真美, 佐藤ゆき, 山中千鶴, 宮下真子, 目時弘仁, 栗山進一, 辻一郎

宮城県公衆衛生学会会誌　(49)　17-17　2017年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
医薬品・医療機器等安全性情報報告制度の活用に関する現状と課題

小原拓, 眞野成康

医薬品医療機器レギュラトリーサイエンス = Pharmaceutical and medical device regulatory science　48　(3)　163-169　2017年
出版者・発行元：日本公定書協会
ISSN： 1884-6076
院内副作用情報の収集・管理・報告に関する調査

小原拓, 山口浩明, 松浦正樹, 中川直人, 村井ユリ子, 土屋文人, 北田光一, 眞野成康

日本病院薬剤師会雑誌 = Journal of Japanese Society of Hospital Pharmacists　53　(1)　73-77　2017年1月
出版者・発行元：日本病院薬剤師会
ISSN： 1341-8815
がん専門薬剤師による副作用等情報の集積とJADERの評価

土屋雅美, 土屋雅美, 小原拓, 眞野成康, 眞野成康, 高村千津子

日本医療薬学会年会講演要旨集(Web)　27　2017年

ISSN： 2424-2470
医薬品・医療機器等安全性情報報告制度の活用に関する現状と課題 (特集副作用情報を収集・活用する!)

小原拓, 眞野成康

月刊薬事 = The pharmaceuticals monthly　58　(13)　2863-2868　2016年10月
出版者・発行元：じほう
ISSN： 0016-5980
家庭血圧の季節変動と脳心血管イベントとの関連:HOMED‐BP研究

花澤智大, 花澤智大, 浅山敬, 浅山敬, 渡部大介, 渡部大介, 田辺杏由美, 佐藤倫広, 井上隆輔, 小原拓, 小原拓, 菊谷昌浩, 野村恭子, 目時弘仁, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　39th　387-387　2016年9月30日
出版者・発行元： (NPO)日本高血圧学会
一般地域住民における異なる時間定義に基づく夜間降圧度と脳心血管長期予後との関連―大迫研究―

佐藤倫広, 浅山敬, 浅山敬, 菊谷昌浩, 井上隆輔, 坪田恵, 小原拓, 小原拓, 村上慶子, 松田彩子, 村上任尚, 野村恭子, 目時弘仁, 今井潤, 大久保孝義

日本高血圧学会総会プログラム・抄録集　39th　319-319　2016年9月30日
出版者・発行元： (NPO)日本高血圧学会
わが国の外来患者における家庭血圧測定の現状:10年の変遷

小原拓, 小原拓, 阿部真也, 吉町昌子, 佐藤倫広, 大久保孝義, 眞野成康, 後藤輝明, 今井潤

日本高血圧学会総会プログラム・抄録集　39th　426-426　2016年9月30日
出版者・発行元： (NPO)日本高血圧学会
さまざまな集団における高血圧の疫学(小児、若年、妊娠、超高齢者等) 妊娠中の高血圧

目時弘仁, 佐藤倫広, 村上任尚, 岩間憲之, 石黒真美, 小原拓, 菊谷昌浩, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　39回　237-237　2016年9月
出版者・発行元： (NPO)日本高血圧学会
Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: The BOSHI study

Noriyuki Iwama, The BOSHI Study Group, Hirohito Metoki, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Katsuyo Yagihashi, Hidekazu Nishigori, Takashi Sugiyama, Junichi Sugawara, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai, Kohei Tanaka, Kunihiko Okamura, Kei Asayama, Ryusuke Inoue, Rie Tsuchida, Azusa Hara, Takuo Hirose, Takeshi Kobayashi, Kenta Gonokami, Takanao Hashimoto, Yumiko Watanabe, Misato Nishimura, Maiko Kawaguchi, Yurie Sato, Minako Hoshikawa, Ayano Sasaki, Kasumi Sakurai, Michihiro Sato, Konomi Akutsu, Mami Yamamoto, Aya Shiraishi, Miki Hosaka, Ikuo Tachibana, Maki Omura, Mikiko Ishikawa, Yoshimi Fujii, Hidemi Kobayashi, Kazuyuki Akaishi, Yuko Kikuchi, Kei Tate, Chieko Koishi, Saori Sugawara, Junko Saitou, Hiromi Sasaki, Tomoko Suzuki, Junko Takahashi, Yoko Narita, Satoko Shigihara, Hideko Tada, Yumi Hamada, Nozomi Satou, Nami Satou, Setsuko Sai, Nana Atsumi, Naoko Sekine, Yukari Ueno, Yu Itou, Yukie Obara, Nami Onodera, Asako Sato, Youko Iwasa, Mamiko Abe, Yukari Kido, Risako Komuro, Yukiko Nakamura, Marie Watanabe, Chikako Matsumoto, Koto Oyama, Aya Takahashi, Michiko Kojima, Miyuki Abe, Mariko Sane, Mana Takahashi, Kana Sugata Miho Igari, Haruhi Sasaki, Mizuki Kobayashi, Aya Kikuchi, Risa Yamamoto, Akiho Goto, Eri Yamauchi, Mika Chiba, Sakiko Ota, Hiromi Ishikawa, Akemi Sasaki, Tomoko Kawamura, Hiroko Hiji, Misaki Kishinami, Yurie Kowata, Eiko Yamauchi, Yasuko Takahashi, Naho Sato

Hypertension Research　39　(3)　151-157　2016年3月1日
出版者・発行元： Japanese Society of Hypertension
DOI： 10.1038/hr.2015.108 　

ISSN： 1348-4214 0916-9636
Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study

Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Noriyuki Iwama, Mikiko Katagiri, Hidekazu Nishigori, Yoko Narikawa, Katsuyo Yagihashi, Masahiro Kikuya, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

HYPERTENSION RESEARCH　38　(11)　770-775　2015年11月

DOI： 10.1038/hr.2015.97 　

ISSN： 0916-9636

eISSN： 1348-4214
乳幼児期の身長SDスコアの変化

田中敏章, 磯島豪, 横谷進, 加藤則子, 山縣然太朗, 横道洋司, 田中総一郎, 呉繁夫, 松原博子, 小原拓, 石黒真美, 佐藤ゆき, 目時裕仁, 菊谷昌浩, 栗山進一, 千田勝一, 小野敦史, 細谷光亮

日本成長学会雑誌　21　(2)　94-94　2015年10月
出版者・発行元：日本成長学会
ISSN： 1880-022X
Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide

Miki Hosaka, Hirohito Metoki, Michihiro Satoh, Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Taku Obara, Takuo Hirose, Yutaka Imai

HYPERTENSION RESEARCH　38　(10)　701-707　2015年10月

DOI： 10.1038/hr.2015.64 　

ISSN： 0916-9636

eISSN： 1348-4214
東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小原拓, 目時弘仁, 丹野高三, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之

日本公衆衛生学会総会抄録集　74回　260-260　2015年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
妊娠前・妊娠中・出産後における血圧管理降圧目標と薬剤選択妊娠初期の血圧管理・降圧薬の選択

目時弘仁, 石黒真美, 佐藤倫広, 小原拓, 菊谷昌浩, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　38回　312-312　2015年10月
出版者・発行元： (NPO)日本高血圧学会
東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小原拓, 目時弘仁, 丹野高三, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之

日本公衆衛生学会総会抄録集　74回　260-260　2015年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災時の保険薬局の特例措置に関する認識と情報収集方法

我妻恭行, 佐藤倫広, 小原拓

日本薬剤師会雑誌 = Journal of the Japan Pharmaceutical Association　67　(8)　1153-1155　2015年8月
出版者・発行元：日本薬剤師会
ISSN： 0369-674X
Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study

Michihiro Satoh, Miki Hosaka, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

JOURNAL OF HYPERTENSION　33　(8)　1536-1541　2015年8月

DOI： 10.1097/HJH.0000000000000570 　

ISSN： 0263-6352

eISSN： 1473-5598
Salt intake and the validity of a salt intake assessment system based on a 24-h dietary recall method in pregnant Japanese women

Michihiro Satoh, Yumi Tanno, Miki Hosaka, Hirohito Metoki, Taku Obara, Kei Asayama, Kazuhiko Hoshi, Masakuni Suzuki, Nariyasu Mano, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　37　(6)　459-462　2015年8月

DOI： 10.3109/10641963.2015.1057832 　

ISSN： 1064-1963

eISSN： 1525-6006
Differences between clinic and home blood pressure measurements during pregnancy

Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Nobuo Yaegashi, Shinichi Kuriyama, Yutaka Imai

JOURNAL OF HYPERTENSION　33　(7)　1492-1493　2015年7月

DOI： 10.1097/HJH.0000000000000608 　

ISSN： 0263-6352

eISSN： 1473-5598
Differential effects of angiotensin II receptor blocker and losartan/hydrochlorothiazide combination on central blood pressure and augmentation index 国際誌

Hirohito Metoki, Hirohito Metoki, Taku Obara, Taku Obara, Taku Obara, Taku Obara, Kei Asayama, Kei Asayama, Kei Asayama, Michihiro Satoh, Michihiro Satoh, Miki Hosaka, Noha Elnagar, Yoshinori Miyawaki, Iwao Kojima, Takayoshi Ohkubo, Takayoshi Ohkubo, Takayoshi Ohkubo, Yutaka Imai, Yutaka Imai, Ryusuke Inoue, Junichiro Hashimoto, Masahiro Kikuya, Kazuhito Totsune, Motoya Nakagawa, Shigemichi Tanaka, Kotaro Nakamura, Nanako Hiwatari, Mutsuo Watanabe, Kenji Ito, Ruriko Mori, Hiroki Hoshi, Shuichi Sasaki, Daisuke Nakayama, Kouzou Ohta, Hiroshi Shishido, Youkou Emura, Hideo Odaka, Norihisa Kumasaka, Kazuteru Ohhira, Kuninobu Nihei, Kiyoto Ishibashi, Mitsutoshi Kato, Kiyoshi Uchiba, Masaaki Miyakawa, Hisao Mori, Takao Sugawara, Nobuhisa Yamada, Naoto Yagi, Yutaka Hatori, Tomoko Gomi, Toshio Ikeda, Takeshi Koitabashi, Shuji Arima, Masao Hiwatari

Clinical and Experimental Hypertension　37　(4)　294-302　2015年7月1日

DOI： 10.3109/10641963.2014.960972 　

ISSN： 1064-1963
Correlation Between the Great East Japan Earthquake and Postpartum Depression: A Study in Miyako, Iwate, Japan

Hidekazu Nishigori, Michiho Sasaki, Taku Obara, Toshie Nishigori, Mami Ishikuro, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama, Akira Hosoyachi, Nobuo Yaegashi, Takashi Kobayashi, Noboru Yoshizumi

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　9　(3)　307-312　2015年6月

DOI： 10.1017/dmp.2015.51 　

ISSN： 1935-7893

eISSN： 1938-744X
東日本大震災後の小中学生の保護者が抱く子どもの不安と悩みの特徴宮城県南部の実態調査から

佐藤ゆき, 菊谷昌浩, 宮下真子, 山中千鶴, 石黒真美, 小原拓, 目時弘仁, 土屋菜歩, 中村智洋, 中谷直樹, 寳澤篤, 辻一郎, 呉繁夫, 八重樫伸生, 栗山進一

小児保健研究　74　(講演集)　139-139　2015年5月
出版者・発行元： (公社)日本小児保健協会
ISSN： 0037-4113
Home Blood Pressure Had a Stronger Predictive Power for Infant Birth Weight Than Clinic Blood Pressure: The Boshi Study. 査読有り

Noriyuki Iwama, Hirohito Metoki, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Katsuyo Yagihashi, Hidekazu Nishigori, Takashi Sugiyama, Junichi Sugawara, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

REPRODUCTIVE SCIENCES　22　383A-383A　2015年3月

ISSN： 1933-7191

eISSN： 1933-7205
果物・野菜・海藻摂取とすい臓がん罹患リスク大崎国保コホート研究

鴫原美智子, 小原拓, 永井雅人, 菅原由美, 渡邉崇, 柿崎真沙子, 西野善一, 栗山進一, 辻一郎

宮城県公衆衛生学会会誌　(47)　6-6　2015年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
緑茶成分摂取量と動脈硬化関連指標との関連掛川コホート研究

五十嵐祐子, 小原拓, 石黒真美, 鴫原美智子, 都田桂子, 目時弘仁, 菊谷昌浩, 栗山進一

宮城県公衆衛生学会会誌　(47)　5-5　2015年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
Blood Pressure and Heart Rate Among Pregnant Women Before and After the Great East Japan Earthquake (11, March, 2011) in the BOSHI Study. 査読有り

Hirohito Metoki, Noriyuki Iwama, Zen Watanabe, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Kiyoshi Itoh, Kazuhiko Hoshi, Masakuni Suzuki, Michihiro Satoh, Nobuo Yaegashi, Yutaka Imai

REPRODUCTIVE SCIENCES　22　385A-385A　2015年3月

ISSN： 1933-7191

eISSN： 1933-7205
Association of Aldosterone-to-Renin Ratio With Hypertension Differs by Sodium Intake: The Ohasama Study

Michihiro Satoh, Masahiro Kikuya, Miki Hosaka, Kei Asayama, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Takefumi Mori, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

AMERICAN JOURNAL OF HYPERTENSION　28　(2)　208-215　2015年2月

DOI： 10.1093/ajh/hpu115 　

ISSN： 0895-7061

eISSN： 1941-7225
P1201-22-PM 向精神薬服用妊婦に対して行った授乳に関する情報提供の現状(妊婦・授乳婦,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

八島一史, 菊地紗耶, 小林奈津子, 久道周彦, 眞野成康, 中川直人, 小原拓, 千葉和美, 山本美由紀, 西郡秀和, 加藤佳子, 松浦正樹, 秋山志津子

日本医療薬学会年会講演要旨集　25　(0)　466-466　2015年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.25.0_466_1 　
医薬品リスク管理計画に関する薬剤師の認識

山口浩明, 小原拓, 佐藤倫広, 大久保孝義, 村井ユリ子, 井関健, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　17th　112-112　2014年7月
出版者・発行元： (一社)日本医薬品情報学会
妊娠中の医薬品使用と児の先天奇形との関連レセプトデータに基づく検討

小原拓, 佐藤倫広, 西郡秀和, 目時弘仁, 大久保孝義, 赤沢学, 八重樫伸生, 栗山進一, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　17回　81-81　2014年7月
出版者・発行元： (一社)日本医薬品情報学会
地域子ども長期健康調査のこころとからだの支援

山中千鶴, 宮下真子, 成川洋子, 石黒真美, 小原拓, 目時弘仁, 菊谷昌浩, 寳澤篤, 辻一郎, 栗山進一

宮城県公衆衛生学会会誌　(46)　4-4　2014年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク事業―地域住民コホート調査に関する経過報告

寶澤篤, 寶澤篤, 寶澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之

J Epidemiol　24　(Supplement 1)　67　2014年1月23日

ISSN： 0917-5040
東北メディカル・メガバンク事業―三世代コホート調査に関する経過報告

目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生

J Epidemiol　24　(Supplement 1)　67　2014年1月23日

ISSN： 0917-5040
東北メディカル・メガバンク事業三世代コホート調査の進捗について

目時弘仁, 石黒真美, 小原拓, 佐藤ゆき, 菊谷昌浩, 栗山進一, 寳澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 冨永悌二, 布施昇男, 峯岸直子, 辻一郎, 呉繁夫, 八重樫伸生, 山本雅之

DOHaD研究　3　(1)　46-46　2014年
出版者・発行元：日本DOHaD研究会
ISSN： 2187-2597

詳細を見る詳細を閉じる

第3回日本DOHaD研究会学術集会抄録集【ポスター発表】
レセプトデータに基づく妊娠中の医薬品使用と児の先天奇形との関連に関する検討

小原拓, 西郡秀和, 目時弘仁, 眞野成康, 八重樫伸生, 栗山進一

DOHaD研究　3　(1)　58-58　2014年
出版者・発行元：日本DOHaD研究会
ISSN： 2187-2597

詳細を見る詳細を閉じる

第3回日本DOHaD研究会学術集会抄録集【ポスター発表】
Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study. 国際誌

Kei Kamide, Kei Asayama, Tomohiro Katsuya, Takayoshi Ohkubo, Takuo Hirose, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Hironori Hanada, Lutgarde Thijs, Tatiana Kuznetsova, Yuichi Noguchi, Ken Sugimoto, Mitsuru Ohishi, Shigeto Morimoto, Takeshi Nakahashi, Shin Takiuchi, Toshihiko Ishimitsu, Takuya Tsuchihashi, Masayoshi Soma, Jitsuo Higaki, Hideo Matsuura, Tatsuo Shinagawa, Toshiyuki Sasaguri, Tetsuro Miki, Kazuo Takeda, Kazuaki Shimamoto, Michio Ueno, Naohisa Hosomi, Jyouji Kato, Norio Komai, Shunichi Kojima, Kazuhiro Sase, Toshiyuki Miyata, Hitonobu Tomoike, Yuhei Kawano, Toshio Ogihara, Hiromi Rakugi, Jan A Staessen, Yutaka Imai

Pharmacogenomics　14　(14)　1709-21　2013年11月

DOI： 10.2217/pgs.13.161 　

ISSN： 1462-2416
日-P1-006 一般地域住民におけるセルフメディケーションに関する実態調査(OTC・セルフメディケーション,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

岩森紗希, 松本章裕, 佐藤倫広, 原梓, 菊谷昌浩, 小原拓, 目時弘仁, 廣瀬卓男, 井上隆輔, 浅山敬, 高橋信行, 眞野成康, 佐藤博, 今井潤, 大久保孝義

日本医療薬学会年会講演要旨集　23　354-354　2013年8月28日
出版者・発行元：日本医療薬学会
土-9-O11-21 小児におけるインフルエンザワクチン接種の有効性評価(感染制御(その他)2,一般演題(口頭)11,再興、再考、創ろう最高の医療の未来)

小原拓, 島崎信次郎, 金子健二, 福田純, 中村泰之, 眞野成康, 栗山進一, 八木直人

日本医療薬学会年会講演要旨集　23　216-216　2013年8月28日
出版者・発行元：日本医療薬学会
土-11-O22-19 保険薬局薬剤師における遺伝薬理に関する認識調査(使用状況調査・意識調査1,一般演題(口頭)22,再興、再考、創ろう最高の医療の未来)

小原拓, 阿部真也, 佐藤倫広, 吉町昌子, 後藤輝明

日本医療薬学会年会講演要旨集　23　227-227　2013年8月28日
出版者・発行元：日本医療薬学会
土-11-O22-18 薬剤師における後発医薬品に関する認識の変遷(使用状況調査・意識調査1,一般演題(口頭)22,再興、再考、創ろう最高の医療の未来)

佐藤倫広, 小原拓, 高橋則男, 猪狩有紀恵, 眞野成康, 早坂正孝, 高橋將喜, 北村哲治

日本医療薬学会年会講演要旨集　23　227-227　2013年8月28日
出版者・発行元：日本医療薬学会
日-8-O25-01 薬剤師における後発医薬品に関する認識の変遷(ジェネリック医薬品、有害事象・副作用,一般演題(口頭)25,再興、再考、創ろう最高の医療の未来)

佐藤倫広, 小原拓, 高橋則男, 猪狩有紀恵, 眞野成康, 早坂正孝, 高橋將喜, 鎌田裕, 北村哲治

日本医療薬学会年会講演要旨集　23　230-230　2013年8月28日
出版者・発行元：日本医療薬学会
日-P4-609 保険薬局薬剤師における家庭血圧測定に関する認識(薬物療法(その他),ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

山口浩, 小原拓, 佐藤倫広, 阿部真也, 吉町昌子, 今井潤, 後藤輝明

日本医療薬学会年会講演要旨集　23　452-452　2013年8月28日
出版者・発行元：日本医療薬学会
日-P2-319 治療中高血圧患者の高血圧管理における保険調剤薬局の関与 : J-HOME-Morning研究(治療・臨床試験,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

小原拓, 小林由香, 池田うらら, 保坂実樹, 佐藤倫広, 菊谷昌浩, 目時弘仁, 井上隆輔, 大久保孝義, 眞野成康, 栗山進一, 今井潤

日本医療薬学会年会講演要旨集　23　405-405　2013年8月28日
出版者・発行元：日本医療薬学会
日-P2-303 東日本大震災時の保険薬局の対応に関するアンケート調査(災害医療,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

我妻恭行, 小原拓, 佐藤倫広, 井筒隆宏, 佐々木孝雄, 鈴木常義

日本医療薬学会年会講演要旨集　23　402-402　2013年8月28日
出版者・発行元：日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_402_5 　
The reason why home blood pressure measurements are preferred over clinic or ambulatory blood pressure in Japan

Yutaka Imai, Taku Obara, Kei Asamaya, Takayoshi Ohkubo

HYPERTENSION RESEARCH　36　(8)　661-672　2013年8月

DOI： 10.1038/hr.2013.38 　

ISSN： 0916-9636

eISSN： 1348-4214
妊婦における薬剤の使用に関する疫学調査

小原拓, 石黒真美, 目時弘仁, 菊谷昌浩, 栗山進一, 西郡秀和, 八重樫伸生, 大久保孝義, 眞野成康

宮城県公衆衛生学会会誌　(45)　6-6　2013年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンクにおける地域子どもコホート事業について

菊谷昌浩, 石黒真美, 小原拓, 目時弘仁, 寳澤篤, 辻一郎, 栗山進一

宮城県公衆衛生学会会誌　(45)　10-10　2013年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク事業地域コホート計画について

寳澤篤, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 栗山進一, 辻一郎

宮城県公衆衛生学会会誌　(45)　7-7　2013年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
Breastfeeding leads to lower blood pressure in 7-year-old Japanese children: Tohoku Study of Child Development

Miki Hosaka, Kei Asayama, Jan A Staessen, Takayoshi Ohkubo, Katsuhisa Hayashi, Nozomi Tatsuta, Naoyuki Kurokawa, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Kunihiko Nakai, Yutaka Imai, Hiroshi Satoh

Hypertension Research　36　(2)　117-122　2013年2月

DOI： 10.1038/hr.2012.128 　

ISSN： 0916-9636 1348-4214
土-9-O12-30 レセプトデータに基づく妊娠中の抗菌薬処方状況の把握に関する研究(栄養管理・NST、妊婦・授乳婦,一般演題(口頭)12,再興、再考、創ろう最高の医療の未来)

堀川いずみ, 小原拓, 目時弘仁, 大久保孝義, 八重樫伸生, 眞野成康, 佐藤博, 栗山進一

日本医療薬学会年会講演要旨集　23　(0)　217-217　2013年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_217_5 　
土-11-O20-10 小児の広汎性発達障害患者における処方推移 : レセプトデータに基づく検討(精神科領域2,一般演題(口頭)20,再興、再考、創ろう最高の医療の未来)

佐藤倫広, 栗山進一, 小原拓, 大場延浩, 森川和彦, 石黒真美, 目時弘仁, 西郡秀和, 菊谷昌浩, 眞野成康

日本医療薬学会年会講演要旨集　23　(0)　225-225　2013年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_225_5 　
土-P1-001 東北大学病院における能動的情報提供のための院内広報サイトの構築(一般演題ポスター発表,医療情報システム,再興、再考、創ろう最高の医療の未来)

前川麻央, 眞野成康, 草場美津江, 小原拓, 尾崎芙実, 中川直人, 佐藤真由美, 久道周彦, 松浦正樹, 我妻恭行

日本医療薬学会年会講演要旨集　23　(0)　252-252　2013年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_252_1 　
土-P1-019 東日本大震災後に当院職員が受けた薬に関連する問い合わせに関する調査(一般演題ポスター発表,医薬品情報・データベース,再興、再考、創ろう最高の医療の未来)

吉中千佳, 小原拓, 草場美津江, 松浦正樹, 眞野成康

日本医療薬学会年会講演要旨集　23　(0)　255-255　2013年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_255_1 　
土-P1-029 病院薬剤師の医薬品安全性評価に関する認識および実践に関する調査(一般演題ポスター発表,使用状況調査・意識調査,再興、再考、創ろう最高の医療の未来)

飯田優太郎, 松浦正樹, 佐藤真由美, 眞野成康, 小原拓, 尾崎芙実, 高田紀子, 鈴木理紗子, 佐藤倫広, 青木良子, 天沼喜美子, 大久保孝義

日本医療薬学会年会講演要旨集　23　(0)　256-256　2013年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_256_5 　
日-P3-500 授乳と薬剤使用に関する問い合わせ内容の調査(妊婦・授乳婦,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

尾崎芙実, 佐賀利英, 佐藤真由美, 久道周彦, 松浦正樹, 眞野成康, 小原拓, 前川真央, 吉中千佳, 草場美津江, 中川直人, 飯田優太郎, 鈴木文子, 島田美樹

日本医療薬学会年会講演要旨集　23　(0)　434-434　2013年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_434_5 　
日-P3-503 妊婦に対する気管支喘息治療薬の処方状況の把握に関する研究(妊婦・授乳婦,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

保坂実樹, 小原拓, 目時弘仁, 佐藤倫広, 大久保孝義, 八重樫伸生, 眞野成康, 栗山進一

日本医療薬学会年会講演要旨集　23　(0)　435-435　2013年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_435_2 　
Blood pressure measured in the clinic and at home during pregnancy among nulliparous and multiparous women: The BOSHI study

Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Mami Yamamoto, Konomi Akutsu, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Katsuyo Yagihashi, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

American Journal of Hypertension　26　(1)　141-148　2013年1月

DOI： 10.1093/ajh/hps002 　

ISSN： 0895-7061 1941-7225
Home blood pressure variability as cardiovascular risk factor in the population of ohasama

Kei Asayama, Masahiro Kikuya, Rudolph Schutte, Lutgarde Thijs, Miki Hosaka, Michihiro Satoh, Azusa Hara, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Takuo Hirose, Takayoshi Ohkubo, Jan A. Staessen, Yutaka Imai

Hypertension　61　(1)　61-69　2013年1月

DOI： 10.1161/HYPERTENSIONAHA.111.00138 　

ISSN： 0194-911X 1524-4563
Change of the management of treated hypertensive patients with or without diabetes in Japan

Taku Obara, Takayoshi Ohkubo, Kazuki Ishikura, Taku Shibamiya, Urara Ikeda, Hirohito Metoki, Masahiro Kikuya, Nariyasu Mano, Shinichi Kuriyama, Yutaka Imai

Clinical and Experimental Hypertension　35　(2)　79-86　2013年

DOI： 10.3109/10641963.2012.732640 　

ISSN： 1064-1963 1525-6006
Associations between visit-to-visit variability in blood pressure measured in the office and antihypertensive drugs: The J-HOME-Morning Study

Taku Obara, Masahiro Kikuya, Yuka Kobayashi, Kazuki Ishikura, Urara Ikeda, Mami Ishikuro, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai

Clinical and Experimental Hypertension　35　(4)　285-290　2013年

DOI： 10.3109/10641963.2013.780070 　

ISSN： 1064-1963 1525-6006
Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

Kei Asayama, Takayoshi Ohkubo, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Masahiro Kikuya, Lutgarde Thijs, Jan A Staessen, Yutaka Imai

Hypertension Research　35　(11)　1102-1110　2012年11月

DOI： 10.1038/hr.2012.125 　

ISSN： 0916-9636 1348-4214
Pharmacists' awareness and attitude toward blood pressure measurement at home and in the pharmacy in Japan

Taku Obara, Takayoshi Ohkubo, Koji Tanaka, Michihiro Satoh, Kazuki Ishikura, Mitsuru Kobayashi, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Yuriko Murai, Nariyasu Mano, Sentaro Oide, Yutaka Imai

Clinical and Experimental Hypertension　34　(6)　447-455　2012年10月

DOI： 10.3109/10641963.2012.666599 　

ISSN： 1064-1963 1525-6006
新生児の血圧分布に関する研究 BOSHI 新生児研究

井上隆輔, 目時弘仁, 大久保孝義, 小原拓, 菊谷昌浩, 多田秀子, 八木橋香津代, 田中耕平, 星和彦, 森滋, 鈴木雅洲, 今井潤

日本高血圧学会総会プログラム・抄録集　35回　410-410　2012年9月
出版者・発行元： (NPO)日本高血圧学会
左室肥大と家庭血圧に基づく治療抵抗性高血圧との関連 J-HOME-Morning研究

小林由香, 小原拓, 大久保孝義, 菊谷昌浩, 井上隆輔, 目時弘仁, 池田うらら, 佐藤博, 今井潤

日本高血圧学会総会プログラム・抄録集　35回　411-411　2012年9月
出版者・発行元： (NPO)日本高血圧学会
一般住民における血漿アルドステロン濃度/血漿レニン活性比(ARR)と高血圧発症の関連大迫研究

佐藤倫広, 菊谷昌浩, 大久保孝義, 森建文, 宇津木恵, 田, 目時弘仁, 廣瀬卓男, 原梓, 小原拓, 井上隆輔, 浅山敬, 戸恒和人, 星晴久, 今井潤

日本高血圧学会総会プログラム・抄録集　35回　394-394　2012年9月
出版者・発行元： (NPO)日本高血圧学会
同居家族の喫煙は脳卒中発症の危険因子である大迫研究

井上隆輔, 大久保孝義, 菊谷昌浩, 関真美, 浅山敬, 目時弘仁, 小原拓, 廣瀬卓男, 原梓, 橋本貴尚, 佐藤倫広, 星晴久, 戸恒和人, 根東義明, 今井潤

日本高血圧学会総会プログラム・抄録集　35回　400-400　2012年9月
出版者・発行元： (NPO)日本高血圧学会
Methodology on Study Using Administrative Data of Selective Serotonin Reuptake Inhibitors during Pregnancy and the Risk of Infants

Aiko Shono, Taku Obara, Shinichi Kuriyama, Manabu Akazawa

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　21　389-389　2012年8月

ISSN： 1053-8569
Home blood pressure level, blood pressure variability, smoking, and stroke risk in Japanese men: The ohasama study

Takanao Hashimoto, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

American Journal of Hypertension　25　(8)　883-891　2012年8月

DOI： 10.1038/ajh.2012.62 　

ISSN： 0895-7061 1941-7225
Prescription of Drugs during Pregnancy in Japan 査読有り

Obara Taku, Akazawa Manabu, Ohkubo Takayoshi, Ishikuro Mami, Metoki Hirohito, Shono Aiko, Nishigori Hidekazu, Mano Nariyasu, Yaegashi Nobuo, Kuriyama Shinichi

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　21　380　2012年8月

ISSN： 1053-8569
母親の妊娠期間中血圧値と娘の妊娠期間中血圧推移の関連 BOSHI研究

目時弘仁, 星川美奈子, 大久保孝義, 八木橋香津代, 櫻井香澄, 石黒真美, 小原拓, 菊谷昌浩, 松原洋一, 森滋, 鈴木雅洲, 佐藤博, 栗山進一, 八重樫伸生, 今井潤

東北公衆衛生学会誌　(61)　41-41　2012年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
血圧コントロール不良例の頻度とその規定因子(J-HOME研究) (特集血圧コントロール不良への対処 : 臨床高血圧の最重要課題をどう対処しますか?) -- (血圧コントロール不良例の実際)

小原拓, 大久保孝義

治療　94　(7)　1206-1211　2012年7月
出版者・発行元：南山堂
ISSN： 0022-5207
Associations between day-by-day variability in blood pressure measured at home and antihypertensive drugs: The J-HOME-morning study home

Kazuki Ishikura, Taku Obara, Tetsuo Kato, Masahiro Kikuya, Taku Shibamiya, Takahiro Shinki, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai, Makoto Yoshida, S. Aoki, H. Ido, K. Ito, K. Kikuchi, I. Maeda, T. Mito, A. Nunokawa, K. Oda, N. Suzuki, Y. Takagawa, K. Tateda, S. Tateda, M. Akimot, G. Tashima, Y. Fujii, G. Onodera, T. Onodera, N. Sugiuchi, Y. Suzuki, R. Domon, T. Hayashi, K. Ishibashi, K. Ito, S. Kataoka, S. Kyogoku, H. Mashiko, K. Matsuo, H. Metoki, Y. Otake, J. Saito, Y. Shishido, A. Takayama, Y. Tanno, S. Toyota, N. Uchida, M. Yambe, M. Fujioka, Y. Kimura, H. Matsuoka, K. Sasaki, M. Wada, H. Yamamoto, T. Goto, Y. Kamimura, H. Kitamura, Y. Matsuura, Y. Nakayama, F. Araki, Y. Miyazaki, T. Sakata, H. Sakuma, T. Sato, K. Shimizu, M. Yoshida, Y. Deguchi, T. Kano, A. Nishiyama, I. Shinotsuka, T. Kobayashi, S. Kumakura, T. Masuda, T. Watanabe, T. Honzawa, H. Kubo, H. Aoki, S. Kanozawa, H. Koide, K. Nishiyama, K. Sakamoto, J. Suda, T. Tagaya, A. Yamada, K. Yamanaka, R. Hasegawa, S. Hirai, K. Horibe, A. Jujo, M. Suzuki, N. Tamiya, T. Ueda, T. Umimura, N. Aoki, S. Arai, T. Himeno, T. Ikeda, H. Inoue, Y. Itagaki, F. Kamata, M. Kamegai, M. Kato, S. Kijima, F. Kotou, T. Kurokawa, H. Kurumatani, K. Minagawa, T. Miura, Y. Miyoshi, T. Morikawa, T. Morita, M. Nago, H. Nakada, H. Nakagawa, J. Nakamura, A. Niwa, E. Osuga, H. Ozaki, A. Sasaki, H. Sugahara, K. Suzuki, H. Tamura, H. Tomonari, M. Yamada, H. Kikuchi, T. Mikawa, K. Minamisawa, M. Miyakawa, M. Nishimura, T. Shinkai, M. Ushiyama, H. Yamamoto, S. Yokoyama, A. Horiuchi, M. Nagasaka, M. Fujita, N. Hoshiyama, M. Ikeda, A. Sakairi, T. Shinozaki, H. Takaki, K. Uchiba, H. Yanagisawa, S. Kobayashi, K. Sasaki, M. Takahashi, S. Takahashi, K. Doniwa, H. Higashi, N. Ohya, M. Yasuhara, S. Saiki, H. Ando, M. Fujii, K. Miyoshi, K. Fuchimoto, M. Kogure, K. Sugiura, T. Suzuki, N. Takahashi, Y. Takahira, N. Adachi, Y. Koyama, Y. Miyazaki, S. Nakamura, G. Narita, O. Nojiri, Y. Okamoto, K. Sakakura, M. Takasawa, T. Takenaka, H. Tatematsu, T. Uno, Y. Watanabe, N. Ishida, U. Kano, N. Morita, H. Okano, T. Takahashi, O. Yamaoka, H. Hayashi, O. Kuroda, Y. Matsushita, T. Mizuno, Y. Taniguchi, M. Yamashita, S. Arai, Y. Fujimura, S. Fujita, T. Hakuto, Y. Ikuno, H. Ishida, R. Kondo, K. Masaki, K. Nao, A. Numata, S. Saeki, H. Sakamoto, K. Suyama, K. Takada, T. Takenaka, K. Teramoto, G. Ueda, N. Wakaki, T. Yokotani, N. Handa, S. Katsuya, K. Kondo, K. Nagamatsu, K. Nakamura, T. Okano, H. Omori, N. Takahashi, Y. Tsuji, Y. Yanaka, Y. Yonezawa, Y. Matsumura, Y. Nakamura, K. Sawada, H. Shimomura, H. Suzuki, K. Furuta, N. Tamaki, Y. Wanaka, A. Inoue, M. Kamura, N. Yuhara, A. Fushimi, Y. Ido, I. Karai, K. Kurosumi, N. Maeda, T. Nishigaki, Y. Nishihara, T. Shindo, T. Yoshimoto, T. Furue, S. Ikeda, K. Kishizuchi, A. Ozawa, J. Ozawa, N. Sasaki, S. Sasaki, N. Shigeto, M. Tanabe, H. Yoshimoto, T. Hirokuni, M. Nakatsuka, T. Noda, M. Tosaka, Y. Toshima, T. Wada, M. Wakimoto, T. Yamanaka, M. Kimura, A. Ota, T. Fukui, W. Furumoto, K. Mashima, T. Nakatsu, T. Yokoi, T. Nakayama, S. Azakami, T. Eto, Y. Fujishima, Y. Fukudome, S. Goto, H. Hara, Y. Harada, T. Hoashi, K. Imoto, R. Inoue, T. Ishizaki, Y. Ito, T. Ito, T. Jinnochi, A. Kawasaki, S. Miake, J. Miyagi, K. Nagasawa, K. Okada, T. Okita, T. Otonari, Y. Tachikawa, K. Takaki, S. Tanaka, H. Urata, S. Yoshioka, H. Ikeda, R. Kaihara, T. Kuwahara, I. Matsuo, O. Nagata, H. Saito, R. Shindo, Y. Takeoka, A. Ito, S. Kusano, M. Tokunaga, S. Hamasaki, Y. Honda, K. Iwai, K. Izuno, K. Koyama, H. Maeda, A. Maki, F. Semba, S. Yi, H. K, K. Ninomiya, Y. Endo, Y. Ezaki, R. Narita, I. Hatashida, S. Komaki, R. Kuroiwa, H. Yoshii, Y. Nakamura

Clinical and Experimental Hypertension　34　(4)　297-304　2012年7月

DOI： 10.3109/10641963.2012.681087 　

ISSN： 1064-1963 1525-6006
Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Michihiro Satoh, Taku Obara, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

Clinical and Experimental Hypertension　34　(4)　284-289　2012年7月

DOI： 10.3109/10641963.2012.681085 　

ISSN： 1064-1963 1525-6006
The velocity of antihypertensive effect of losartan/hydrochlorothiazide and angiotensin II receptor blocker

Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Ryusuke Inoue, Taku Obara, Takuo Hirose, Michihiro Sato, Takanao Hashimoto, Yutaka Imai

Journal of Hypertension　30　(7)　1478-1486　2012年7月

DOI： 10.1097/HJH.0b013e328353f1fe 　

ISSN： 0263-6352 1473-5598
レセプトデータに基づく妊娠中の医薬品使用状況の把握に関する研究

小原拓, 石黒真美, 目時弘仁, 西郡秀和, 大久保孝義, 眞野成康, 八重樫伸生, 栗山進一

日本医薬品情報学会総会・学術大会講演要旨集　15回　105-105　2012年6月
出版者・発行元： (一社)日本医薬品情報学会
妊婦コホートにおける医薬品使用状況に関する調査方法の検討

小林由香, 小原拓, 目時弘仁, 眞野成康, 佐藤博, 今井潤, 八重樫伸生, 栗山進一

日本医薬品情報学会総会・学術大会講演要旨集　15回　107-107　2012年6月
出版者・発行元： (一社)日本医薬品情報学会
Evaluating home blood pressure in treated hypertensives in comparison with the referential value of casual screening of blood pressure: the Ohasama study

Daisaku Yasui, Kei Asayama, Noriko Takada, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Jan A. Staessen, Yutaka Imai

BLOOD PRESSURE MONITORING　17　(3)　89-95　2012年6月

DOI： 10.1097/MBP.0b013e328351de34 　

ISSN： 1359-5237

eISSN： 1473-5725
PLASMA RENIN ACTIVITY AND ALDOSTERONE-TO-RENIN RATIO ARE ASSOCIATED WITH THE DEVELOPMENT OF CHRONIC KIDNEY DISEASE: THE OHASAMA STUDY

Michihiro Satoh, Shiho Terata, Masahiro Kikuya, Takayoshi Ohkubo, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masaaki Nakayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

NEPHROLOGY DIALYSIS TRANSPLANTATION　27　121-121　2012年5月

ISSN： 0931-0509
Blood pressure changes during pregnancy

Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Nobuo Yaegashi, Shinichi Kuriyama, Yutaka Imai

Hypertension Research　35　(5)　563-564　2012年5月

DOI： 10.1038/hr.2012.33 　

ISSN： 0916-9636 1348-4214
治療中高血圧患者の高血圧管理における保険調剤薬局の関与 J-HOME-Morning研究より

小原拓, 小林由香, 池田うらら, 菊谷昌浩, 目時弘仁, 井上隆輔, 大久保孝義, 眞野成康, 栗山進一, 今井潤

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　1回　101-101　2012年4月
出版者・発行元： (NPO)日本高血圧学会
妊娠中Pulse Wave Velocity(PWV)と妊娠高血圧症候群(PIH)及び家庭血圧推移との関連 BOSHI研究

阿久津好美, 目時弘仁, 大久保孝義, 小原拓, 石黒真美, 山本真実, 櫻井香澄, 藤井良美, 立花郁雄, 八木橋香津代, 菊谷昌浩, 森滋, 鈴木雅洲, 佐藤博, 松原洋一, 八重樫伸生, 今井潤

日本妊娠高血圧学会雑誌　19　95-96　2012年1月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
初産婦・経産婦における妊娠中の外来血圧及び家庭血圧推移 BOSHI研究

石黒真美, 小原拓, 目時弘仁, 大久保孝義, 山本真実, 阿久津好美, 櫻井香澄, 岩間憲之, 片桐未希子, 八木橋香津代, 鈴木雅洲, 八重樫伸生, 栗山進一, 今井潤

日本妊娠高血圧学会雑誌　19　99-100　2012年1月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
妊娠初期の食塩摂取量と妊娠高血圧症候群発症との関連 BOSHI研究

山本真実, 小原拓, 目時弘仁, 大久保孝義, 石黒真美, 阿久津好美, 櫻井香澄, 片桐未希子, 岩間憲之, 八木橋香津, 鈴木雅洲, 栗山進一, 八重樫伸生, 今井潤

日本妊娠高血圧学会雑誌　19　202-203　2012年1月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
PIHと脳血管障害をめぐる諸問題 24時間自由行動下血圧・家庭血圧と脳血管障害

目時弘仁, 大久保孝義, 小原拓, 阿久津好美, 山本真実, 石黒真美, 櫻井香澄, 岩間憲之, 片桐未希子, 菊谷昌浩, 八木橋香津代, 森滋, 鈴木雅洲, 栗山進一, 八重樫伸生, 今井潤

日本妊娠高血圧学会雑誌　19　49-53　2012年1月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
P2-518 妊婦における葉酸サプリメント摂取の現状(妊婦・授乳婦,ポスター,一般演題,岐路に立つ医療～千年紀の目覚め～よみがえれ!ニッポン!薬の改革は我らが手で!)

小林由香, 小原拓, 村井ユリ子, 目時弘仁, 佐藤博, 今井潤

日本医療薬学会年会講演要旨集　22　(0)　464-464　2012年
出版者・発行元：一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.22.0_464_6 　
Ambulatory Versus Home Versus Clinic Blood Pressure The Association With Subclinical Cerebrovascular Diseases: The Ohasama Study

Azusa Hara, Kazushi Tanaka, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Hirohito Metoki, Takanao Hashimoto, Michihiro Satoh, Ryusuke Inoue, Kei Asayama, Taku Obara, Takuo Hirose, Shin-Ichi Izumi, Hiroshi Satoh, Yutaka Imai

HYPERTENSION　59　(1)　22-U99　2012年1月

DOI： 10.1161/HYPERTENSIONAHA.111.174938 　

ISSN： 0194-911X

eISSN： 1524-4563
Mother-off spring aggregation in home versus conventional blood pressure in the Tohoku Study of Child Development (TSCD)

Kei Asayama, Jan A. Staessen, Katsuhisa Hayashi, Miki Hosaka, Nozomi Tatsuta, Naoyuki Kurokawa, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Takayoshi Ohkubo, Kunihiko Nakai, Yutaka Imai, Hiroshi Satoh

Acta Cardiologica　67　(4)　449-456　2012年

DOI： 10.2143/AC.67.4.2170687 　

ISSN： 0001-5385
高血圧薬物治療における家庭血圧測定と薬剤師の介入

吉町昌子, 小原拓, 川端ゆかり, 馬庭ちはる, 河野弘之, 眞野成康, 大久保孝義, 後藤輝明

医薬品相互作用研究　35　(2)　63-69　2011年11月
出版者・発行元：医薬品相互作用研究会
ISSN： 0385-5015
レセプトデータを用いた妊娠高血圧患者に対する降圧薬処方状況の把握

小原拓, 大久保孝義, 目時弘仁, 西郡秀和, 石黒真美, 眞野成康, 赤沢学, 八重樫伸生, 栗山進一

日本薬剤疫学会学術総会抄録集　17回　76-77　2011年11月
出版者・発行元： (一社)日本薬剤疫学会
電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 主結果報告

大久保孝義, 浅山敬, 井上隆輔, 小原拓, 目時弘仁, 菊谷昌浩, 三浦幸雄, Staessen Jan A, 今井潤, HOMED-BP研究グループ

日本高血圧学会総会プログラム・抄録集　34回　323-323　2011年10月
出版者・発行元： (NPO)日本高血圧学会
電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 家庭血圧降圧レベルと予後との関連

浅山敬, 大久保孝義, 井上隆輔, 小原拓, 目時弘仁, 菊谷昌浩, 三浦幸雄, Staessen Jan A, 今井潤, HOMED-BP研究グループ

日本高血圧学会総会プログラム・抄録集　34回　327-327　2011年10月
出版者・発行元： (NPO)日本高血圧学会
高血圧薬物治療における家庭血圧測定と薬剤師の介入

吉町昌子, 小原拓, 川端ゆかり, 馬庭ちはる, 河野弘之, 眞野成康, 大久保孝義, 後藤輝明

日本高血圧学会総会プログラム・抄録集　34回　621-621　2011年10月
出版者・発行元： (NPO)日本高血圧学会
降圧治療中患者における家庭血圧日間変動の規定因子 J-HOME-Morning研究

小原拓, 石倉一樹, 菊谷昌浩, 加藤哲夫, 芝宮拓, 新木貴大, 池田うらら, 小林由香, 目時弘仁, 眞野成康, 栗山進一, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　527-527　2011年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧・血圧日間変動と認知機能低下との関連大迫研究

松本章裕, 佐藤倫広, 菊谷昌浩, 大久保孝義, 橋本貴尚, 原梓, 目時弘仁, 廣瀬卓男, 小原拓, 井上隆輔, 浅山敬, 戸恒和人, 星晴久, 佐藤洋, 佐藤博, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　372-372　2011年10月
出版者・発行元： (NPO)日本高血圧学会
血漿アルドステロン/レニン比とCKD発症に関する縦断的検討大迫研究

寺田志保, 菊谷昌浩, 佐藤倫広, 大久保孝義, 橋本貴尚, 原梓, 廣瀬卓男, 目時弘仁, 井上隆輔, 小原拓, 浅山敬, 星晴久, 戸恒和人, 佐藤洋, 佐藤博, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　520-520　2011年10月
出版者・発行元： (NPO)日本高血圧学会
同居家族の喫煙は家庭高血圧発症の危険因子である大迫研究

井上隆輔, 大久保孝義, 菊谷昌浩, 関真美, 浅山敬, 目時弘仁, 小原拓, 廣瀬卓男, 原梓, 橋本貴尚, 佐藤倫広, 星晴久, 戸恒和人, 佐藤洋, 根東義明, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　527-527　2011年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧によるHome Arterial Stiffness Index(HASI)と頸動脈病変との関連大迫研究

菊谷昌浩, 大久保孝義, 佐藤倫広, 橋本貴尚, 原梓, 廣瀬卓男, 目時弘仁, 井上隆輔, 小原拓, 浅山敬, 星晴久, 戸恒和人, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　528-528　2011年10月
出版者・発行元： (NPO)日本高血圧学会
母の家庭血圧が7歳児の家庭血圧値および家庭心拍数に与える影響について

保坂実樹, 浅山敬, 龍田希, 佐藤倫広, 橋本貴尚, 小原拓, 目時弘仁, 黒川修行, 菊谷昌浩, 大久保孝義, 仲井邦彦, Staessen Jan A, 今井潤, 佐藤洋

日本高血圧学会総会プログラム・抄録集　34回　585-585　2011年10月
出版者・発行元： (NPO)日本高血圧学会
妊娠期間中血圧推移と妊婦の母親の妊娠期間中血圧レベルとの関連 BOSHI研究

目時弘仁, 星川美奈子, 大久保孝義, 阿久津好美, 小原拓, 櫻井香澄, 片桐未希子, 岩間憲之, 八木橋香津代, 森滋, 鈴木雅洲, 栗山進一, 松原洋一, 八重樫伸生, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　437-437　2011年10月
出版者・発行元： (NPO)日本高血圧学会
正常妊娠における妊娠初期ヘマトクリット(Ht)と家庭血圧推移との関連 BOSHI研究

阿久津好美, 佐々木彩乃, 目時弘仁, 大久保孝義, 小原拓, 櫻井香澄, 八木橋香津代, 菊谷昌浩, 森滋, 鈴木雅洲, 佐藤博, 栗山進一, 松原洋一, 八重樫伸生, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　585-585　2011年10月
出版者・発行元： (NPO)日本高血圧学会
降圧治療中患者における減塩の医療経済効果

佐藤慶子, 大久保孝義, 小林慎, 菊谷昌浩, 小原拓, 目時弘仁, 浅山敬, 鈴木一夫, 佐藤博, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　520-520　2011年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧測定に基づくβ遮断薬ビソプロロールの脈拍減少、降圧および降圧速度の評価

佐藤倫広, 小原拓, 池田うらら, 小林由香, 目時弘仁, 浅山敬, 菊谷昌浩, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　583-583　2011年10月
出版者・発行元： (NPO)日本高血圧学会
一般住民における血漿アルドステロン/血漿レニン活性比(ARR)とnon-dippingおよびNa排泄量との関連大迫研究

佐藤倫広, 菊谷昌浩, 大久保孝義, 森建文, 橋本貴尚, 目時弘仁, 原梓, 坪田恵, 廣瀬卓男, 小原拓, 井上隆輔, 浅山敬, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　518-518　2011年10月
出版者・発行元： (NPO)日本高血圧学会
喫煙習慣は男性における家庭血圧値・血圧日間変動の脳卒中発症リスクを上昇させるか? 大迫研究

橋本貴尚, 菊谷昌浩, 大久保孝義, 佐藤倫広, 目時弘仁, 井上隆輔, 浅山敬, 菅野厚博, 小原拓, 廣瀬卓男, 星晴久, 戸恒和人, 佐藤洋, 佐藤博, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　477-477　2011年10月
出版者・発行元： (NPO)日本高血圧学会
降圧治療中患者における早朝家庭血圧管理と脳心血管疾患発症との関連 J-HOME-Morning研究

池田うらら, 小原拓, 大久保孝義, 菊谷昌浩, 小林由香, 石倉一樹, 目時弘仁, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　528-528　2011年10月
出版者・発行元： (NPO)日本高血圧学会
P-0943 うつ症状と労働状況、および睡眠薬服用状況に関する実態調査 : 社団法人仙台市薬剤師会(一般演題ポスター発表,精神科領域,Enjoy Pharmacists' Lifestyles)

佐藤倫広, 小原拓, 高橋將喜, 早坂正孝, 鎌田裕, 北村哲治

日本医療薬学会年会講演要旨集　21　339-339　2011年9月9日
出版者・発行元：日本医療薬学会
スズキ記念病院(産科系病院)におけるお薬相談の実績と展望

岩崎雅弘, 小原拓, 西村美里, 目時弘仁, 鈴木瑛美, 吉田美希, 館圭, 松田祐子, 蛯子学, 佐藤友理恵, 渡邉悠美子, 八木橋香津代, 大久保孝義, 今井潤, 鈴木雅州

医薬品相互作用研究　34　(3)　145-149　2011年4月
出版者・発行元：医薬品相互作用研究会
ISSN： 0385-5015
スズキ記念病院における妊婦への処方状況 BOSHI研究

佐々木彩乃, 目時弘仁, 佐藤友里恵, 星川美奈子, 阿久津好美, 小原拓, 大久保孝義, 岩崎雅弘, 今井潤, 鈴木雅州

日本薬学会年会要旨集　131年会　(4)　181-181　2011年3月
出版者・発行元： (公社)日本薬学会
ISSN： 0918-9823
家庭血圧測定に基づくCa拮抗薬エホニジピン塩酸塩の臨床評価

小林由香, 石倉一樹, 小原拓, 吉田愛琴, 池田うらら, 廣瀬卓男, 大久保孝義, 佐藤博, 今井潤

Therapeutic Research　32　(3)　349-355　2011年3月
出版者・発行元：ライフサイエンス出版(株)
ISSN： 0289-8020
家庭血圧測定を用いた低用量エプレレノン(25mg/日)の有用性に関する検討

石倉一樹, 小原拓, 吉田愛琴, 池田うらら, 佐々木彩乃, 廣瀬卓男, 大久保孝義, 今井潤

Therapeutic Research　32　(3)　357-364　2011年3月
出版者・発行元：ライフサイエンス出版(株)
ISSN： 0289-8020
高血圧専門外来に通院中の高血圧患者における家庭血圧測定

吉田愛琴, 小原拓, 石倉一樹, 池田うらら, 眞野成康, 大久保孝義, 今井潤

血圧　18　(3)　279-285　2011年3月
出版者・発行元： (株)先端医学社
ISSN： 1340-4598
ロスバスタチン2.5mg隔日服用における脂質改善効果および降圧効果の評価

佐々木彩乃, 小原拓, 石倉一樹, 吉田愛琴, 池田うらら, 目時弘仁, 大久保孝義, 佐藤博, 今井潤

Therapeutic Research　32　(2)　223-230　2011年2月
出版者・発行元：ライフサイエンス出版(株)
ISSN： 0289-8020
Role of Pharmacists in the Management of Hypertensive Patients

Taku Obara, Sentaro Oide, Takayoshi Ohkubo, Nariyasu Mano, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　24　(1)　2-3　2011年1月

DOI： 10.1038/ajh.2010.208 　

ISSN： 0895-7061
家庭血圧測定にもとづく選択的アルドステロン受容体拮抗薬エプレレノン25mg/日の臨床評価スピロノラクトン12.5mg/日からの切り替え

石倉一樹, 小原拓, 吉田愛琴, 池田うらら, 佐々木彩乃, 廣瀬卓男, 大久保孝義, 今井潤

血圧　17　(12)　1058-1062　2010年12月
出版者・発行元： (株)先端医学社
ISSN： 1340-4598
母親の妊娠期間中血圧値と娘の妊娠期間中血圧推移の関連 BOSHI研究

星川美奈子, 目時弘仁, 大久保考義, 佐藤友里恵, 佐々木彩乃, 阿久津好美, 白石彩, 八木橋香津代, 櫻井香澄, 小原拓, 菊谷昌浩, 松原洋一, 森滋, 鈴木雅洲, 佐藤博, 八重樫伸生, 今井潤

日本妊娠高血圧学会雑誌　18　180-181　2010年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
正常妊娠における妊娠初期ヘマトクリット(Ht)と家庭血圧推移との関連 BOSHI研究

佐々木彩乃, 目時弘仁, 大久保孝義, 佐藤友里恵, 星川美奈子, 阿久津好美, 白石彩, 八木橋香津代, 櫻井香澄, 小原拓, 菊谷昌浩, 松原洋一, 森滋, 鈴木雅洲, 佐藤博, 八重樫伸生, 今井潤

日本妊娠高血圧学会雑誌　18　142-143　2010年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
妊婦の出生体重及び妊娠前肥満度と妊娠中の家庭血圧推移 BOSHI研究

佐藤友里恵, 目時弘仁, 大久保孝義, 佐々木彩乃, 星川美奈子, 阿久津好美, 白石彩, 八木橋香津代, 櫻井香澄, 小原拓, 菊谷昌浩, 松原洋一, 森滋, 鈴木雅洲, 佐藤博, 八重樫伸生, 今井潤

日本妊娠高血圧学会雑誌　18　146-147　2010年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
妊娠期間中の血圧推移 BOSHI研究

目時弘仁, 大久保孝義, 佐藤友里恵, 佐々木彩乃, 星川美奈子, 阿久津好美, 白石彩, 八木橋香津代, 櫻井香澄, 小原拓, 菊谷昌浩, 伊藤潔, 松原洋一, 森滋, 鈴木雅洲, 佐藤博, 八重樫伸生, 今井潤

日本妊娠高血圧学会雑誌　18　193-194　2010年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
P2-503 家庭血圧測定に基づく低用量エプレレノン(25mg/日)の臨床評価(一般演題ポスター発表,薬物療法(その他),臨床から学び臨床へと還元する医療薬学)

石倉一樹, 小原拓, 吉田愛琴, 池田うらら, 佐々木彩乃, 廣瀬卓男, 大久保孝義, 今井潤

日本医療薬学会年会講演要旨集　20　473-473　2010年10月25日
出版者・発行元：日本医療薬学会
P2-502 家庭血圧測定に基づくアンジオテンシンII受容体拮抗薬イルベサルタンの降圧効果および薬効持続に関する検討(一般演題ポスター発表,薬物療法(その他),臨床から学び臨床へと還元する医療薬学)

吉田愛琴, 小原拓, 石倉一樹, 小林由香, 廣瀬卓男, 大久保孝義, 眞野成康, 今井潤

日本医療薬学会年会講演要旨集　20　473-473　2010年10月25日
出版者・発行元：日本医療薬学会
P1-125 日本の高血圧診療における利尿薬使用の現状 : J-HOME Morning研究(一般演題ポスター発表,使用状况調査・意識調査,臨床から学び臨床へと還元する医療薬学)

池田うらら, 小原拓, 石倉一樹, 吉田愛琴, 小林由香, 大久保孝義, 佐藤博, 今井潤

日本医療薬学会年会講演要旨集　20　307-307　2010年10月25日
出版者・発行元：日本医療薬学会
P2-138 ロサルタン/ヒドロクロロチアジド合剤の医療経済学的評価 : 家庭血圧を用いた検討(一般演題ポスター発表,薬剤疫学・医療経済,臨床から学び臨床へと還元する医療薬学)

佐藤慶子, 大久保孝義, 小林慎, 目時弘仁, 小原拓, 浅山敬, 井上隆輔, 佐藤博, 今井潤

日本医療薬学会年会講演要旨集　20　413-413　2010年10月25日
出版者・発行元：日本医療薬学会
電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 対象者のベースライン特性 HOMED-BP研究グループを代表して

大久保孝義, 浅山敬, 高橋ちひろ, 井上隆輔, 目時弘仁, 小原拓, 三浦幸雄, 今井潤

日本高血圧学会総会プログラム・抄録集　33回　273-273　2010年10月
出版者・発行元： (NPO)日本高血圧学会
降圧治療中患者における家庭血圧管理と腎機能低下に関する縦断的検討 J-HOME-Morning研究

石倉一樹, 小原拓, 吉田愛琴, 池田うらら, 目時弘仁, 井上隆輔, 浅山敬, 中山昌明, 菊谷昌浩, 大久保孝義, 今井潤, J-HOME-Mornig研究グループ

日本高血圧学会総会プログラム・抄録集　33回　277-277　2010年10月
出版者・発行元： (NPO)日本高血圧学会
カルシウム拮抗薬・アンジオテンシン変換酵素阻害薬・アンジオテンシンII受容体拮抗薬の単剤服用者への、利尿薬併用効果に関する利尿薬種別・用量別検討 HOMED-BP研究サブ分析

高橋ちひろ, 浅山敬, 井上隆輔, 大久保孝義, 目時弘仁, 小原拓, 三浦幸雄, 佐藤博, 今井潤

日本高血圧学会総会プログラム・抄録集　33回　378-378　2010年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧測定に基づくカルシウム拮抗薬シルニジピンの降圧効果および薬効持続の検討

吉田愛琴, 小原拓, 石倉一樹, 佐々木彩乃, 池田うらら, 目時弘仁, 浅山敬, 井上隆輔, 菊谷昌浩, 大久保孝義, 眞野成康, 今井潤

日本高血圧学会総会プログラム・抄録集　33回　372-372　2010年10月
出版者・発行元： (NPO)日本高血圧学会
アドレノメデュリン2/インターメジン遺伝子多型と血圧、腎機能、無症候性脳血管障害との関連の検討大迫研究

廣瀬卓男, 戸恒和人, 目時弘仁, 原梓, 佐藤倫広, 小原拓, 浅山敬, 菊谷昌浩, 近藤健男, 大久保孝義, 出江紳一, 高橋和広, 今井潤

日本高血圧学会総会プログラム・抄録集　33回　379-379　2010年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧を指標とする降圧薬反応性のゲノムワイド解析 HOMED-BP-GENE研究

勝谷友宏, 浅山敬, 大久保孝義, 杉本研, 神出計, 井上隆輔, 目時弘仁, 小原拓, 大石充, 森下竜一, 荻原俊男, 今井潤, 楽木宏実

日本高血圧学会総会プログラム・抄録集　33回　333-333　2010年10月
出版者・発行元： (NPO)日本高血圧学会
一般住民における血清アルドステロン/血漿レニン活性比(ARR)と脳卒中発症およびNa摂取量との関連大迫研究

佐藤倫広, 菊谷昌浩, 原梓, 大久保孝義, 森建文, 目時弘仁, 宇津木恵, 廣瀬卓男, 小原拓, 井上隆輔, 浅山敬, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　33回　236-236　2010年10月
出版者・発行元： (NPO)日本高血圧学会
受動喫煙の家庭血圧に対する影響大迫研究

関真美, 井上隆輔, 大久保孝義, 菊谷昌浩, 目時弘仁, 浅山敬, 原梓, 廣瀬卓男, 菅野厚博, 小原拓, 橋本貴尚, 星晴久, 戸恒和人, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　33回　281-281　2010年10月
出版者・発行元： (NPO)日本高血圧学会
Association of environmental tobacco smoke exposure with elevated home blood pressure in Japanese women: The Ohasama study

Mami Seki, Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Hirohito Metoki, Takuo Hirose, Megumi Tsubota-Utsugi, Kei Asayama, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

Journal of Hypertension　28　(9)　1814-1820　2010年9月

DOI： 10.1097/HJH.0b013e32833a3911 　

ISSN： 0263-6352
DECREASED MID PREGNANCY FALL IN HOME BLOOD PRESSURE IN RELATION TO INSULIN RESISTANCE: THE BOSHI STUDY

M. Kawaguchi, H. Metoki, T. Ohkubo, Y. Sato, A. Sasaki, M. Hoshikawa, K. Akutsu, K. Yagihashi, T. Hashimoto, A. Hara, T. Obara, M. Kikuya, N. Yaegashi, K. Okamura, Y. Matsubara, S. Mori, M. Suzuki, Y. Imai

JOURNAL OF HYPERTENSION　28　E13-E13　2010年6月

ISSN： 0263-6352
自由行動下血圧に基づく高血圧診療の医療経済学的評価

田巻祐一朗, 大久保孝義, 小林慎, 佐藤慶子, 菊谷昌浩, 小原拓, 目時弘仁, 浅山敬, 廣瀬卓男, 戸恒和人, 鈴木一夫, 今井潤

YAKUGAKU ZASSHI　130　(6)　805-820　2010年6月
出版者・発行元：公益社団法人日本薬学会
DOI： 10.1248/yakushi.130.805 　

ISSN： 0031-6903 1347-5231
アンジオテンシンII受容体拮抗薬テルミサルタンの家庭血圧測定にもとづく降圧速度に関する検討

安真美子, 小原拓, 花澤智大, 小笠原慧, 堅田早紀子, 目時弘仁, 浅山敬, 井上隆輔, 菊谷昌浩, 大久保孝義, 今井潤

血圧　17　(5)　445-449　2010年5月
出版者・発行元： (株)先端医学社
ISSN： 1340-4598
アンジオテンシンII受容体拮抗薬オルメサルタンの家庭血圧測定に基づく降圧速度に関する検討

小原拓, 安真美子, 花澤智大, 小笠原慧, 堅田早紀子, 目時弘仁, 浅山敬, 井上隆輔, 菊谷昌浩, 大久保孝義, 眞野成康, 今井潤

Therapeutic Research　31　(4)　569-575　2010年4月
出版者・発行元：ライフサイエンス出版(株)
ISSN： 0289-8020
母親の妊娠期間中血圧レベルと娘の妊娠期間中血圧推移の関連 BOSHI研究

星川美奈子, 目時弘仁, 大久保孝義, 川口麻衣子, 佐藤友里恵, 佐々木綾乃, 阿久津好美, 八木橋香津代, 橋本貴尚, 原梓, 小原拓, 八重樫伸生, 松原洋一, 鈴木雅洲, 今井潤

日本衛生学雑誌　65　(2)　282-282　2010年4月
出版者・発行元： (一社)日本衛生学会
ISSN： 0021-5082
アンジオテンシンII受容体拮抗薬ロサルタンの家庭血圧測定にもとづく降圧速度に関する検討

安真美子, 小原拓, 花澤智大, 小笠原慧, 堅田早紀子, 目時弘仁, 浅山敬, 井上隆輔, 菊谷昌浩, 大久保孝義, 今井潤

血圧　17　(2)　145-150　2010年2月
出版者・発行元： (株)先端医学社
ISSN： 1340-4598
家庭血圧測定に基づく白衣高血圧・仮面高血圧・早朝高血圧 (特集高血圧診療--ガイドラインでどう変わる)

小原拓, 今井潤

綜合臨床　59　(1)　18-23　2010年1月
出版者・発行元：永井書店
ISSN： 0371-1900
Home and office blood pressure control among treated hypertensive patients in Japan: Findings from the Japan home versus office blood pressure measurement evaluation (J-HOME) study. (Pharmaceuticalｓ)

Taku Obara, Takayoshi Ohkubo Michihiro Satoh, Nariyasu Mano, Yutaka Imai

Pharmaceuticalｓ　3　(2)　419-432　2010年

DOI： 10.3390/ph3020419 　

ISSN： 1424-8247
妊娠高血圧症候群の診断をめぐるピットフォール高血圧診断の問題点

目時弘仁, 大久保孝義, 佐藤友里恵, 佐々木彩乃, 星川美奈子, 川口麻衣子, 阿久津好美, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 八木橋香津代, 八重樫伸生, 岡村州博, 松原洋一, 森滋, 鈴木雅洲, 今井潤

日本妊娠高血圧学会雑誌　17　29-32　2009年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
正常血圧妊婦のインスリン抵抗性と妊娠中期の血圧低下との関連 BOSHI研究

川口麻衣子, 目時弘仁, 大久保孝義, 佐々木彩乃, 星川美奈子, 阿久津好美, 八木橋香津代, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 松原洋一, 八重樫伸生, 岡村州博, 森滋, 鈴木雅洲, 今井潤

日本妊娠高血圧学会雑誌　17　186-187　2009年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
妊娠前BMIと妊娠中の家庭血圧推移 BOSHI研究

佐藤友里恵, 目時弘仁, 大久保孝義, 川口麻衣子, 阿久津好美, 佐々木彩乃, 星川美奈子, 八木橋香津代, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 松原洋一, 八重樫伸生, 岡村州博, 森滋, 鈴木雅洲, 今井潤

日本妊娠高血圧学会雑誌　17　192-193　2009年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
血圧の評価 (高血圧(第4版)--日本における最新の研究動向(下)) -- (高血圧治療ガイドラインの概要--JSH2009)

小原拓, 今井潤

日本臨床　67　51-56　2009年11月
出版者・発行元：日本臨床社
ISSN： 0047-1852
Long-Term Risk in Subjects With White-Coat Hypertension

Taku Obara, Takayoshi Ohkubo, Yutaka Imai

HYPERTENSION　54　(5)　E133-E133　2009年11月

DOI： 10.1161/HYPERTENSIONAHA.109.140111 　

ISSN： 0194-911X
Influence of Alcohol Intake on Circadian Blood Pressure Variation in Japanese Men: The Ohasama Study

Manami Nakashita, Takayoshi Ohkubo, Azusa Hara, Hirohito Metoki, Masahiro Kikuya, Takuo Hirose, Megumi Tsubota-Utsugi, Kei Asayama, Ryusuke Inoue, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　22　(11)　1171-1176　2009年11月

DOI： 10.1038/ajh.2009.160 　

ISSN： 0895-7061
家庭血圧・自由行動下血圧に基づく循環器病の予防戦略-大迫研究

今井潤, 浅山敬, 井上隆輔, 小原拓, 菊谷昌浩, 大久保孝義

日本循環器病予防学会誌 = Japanese journal of cardiovascular disease prevention　44　(3)　200-212　2009年10月30日

ISSN： 1346-6267
家庭血圧測定の現状に関する調査保健師の実践と意識

渡邊生恵, 小原拓, 大久保孝義, 丸山良子, 今井潤

日本公衆衛生学会総会抄録集　68回　588-588　2009年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
降圧治療中患者における家庭血圧管理と心電図上左室肥大改善に関する縦断的検討 J-HOME-Morning研究

芝宮拓, 小原拓, 新木貴大, 目時弘仁, 浅山敬, 菊谷昌浩, 大久保孝義, 今井潤, J-HOME-Morning研究グループ

日本高血圧学会総会プログラム・抄録集　32回　191-191　2009年10月
出版者・発行元： (NPO)日本高血圧学会
高血圧患者におけるβ遮断薬投与の家庭心拍減少および降圧効果検証のための介入研究 J-HOME-HR研究

新木貴大, 小原拓, 大久保孝義, 後ノ上健太, 芝宮拓, 目時弘仁, 浅山敬, 菊谷昌浩, 今井潤, J-HOME-HR研究グループ

日本高血圧学会総会プログラム・抄録集　32回　205-205　2009年10月
出版者・発行元： (NPO)日本高血圧学会
電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 終了予定変更とその根拠

大久保孝義, 浅山敬, 井上隆輔, 目時弘仁, 小原拓, 三浦幸雄, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　206-206　2009年10月
出版者・発行元： (NPO)日本高血圧学会
本態性高血圧患者に対する低用量(12.5-25mg/日)スピロノラクトン追加投与の有用性

花澤智大, 小笠原慧, 小原拓, 目時弘仁, 浅山敬, 菊谷昌浩, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　297-297　2009年10月
出版者・発行元： (NPO)日本高血圧学会
Serum magnesium, ambulatory blood pressure, and the prevalence of carotid artery alteration: The Ohasama study

T. Hashimoto, A. Hara, T. Ohkubo, M. Kikuya, Y. Shintani, H. Metoki, R. Inoue, K. Asayama, A. Kanno, M. Nakashita, T. Obara, K. Totsune, H. Hoshi, H. Sato, Y. Imai

INTERNATIONAL JOURNAL OF CARDIOLOGY　137　S145-S145　2009年10月

DOI： 10.1016/j.ijcard.2009.09.499 　

ISSN： 0167-5273
白衣効果と脳卒中発症大迫研究

井上隆輔, 大久保孝義, 菊谷昌浩, 目時弘仁, 浅山敬, 原梓, 廣瀬卓男, 菅野厚博, 小原拓, 星晴久, 戸恒和人, 佐藤洋, 根東義明, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　159-159　2009年10月
出版者・発行元： (NPO)日本高血圧学会
飲酒習慣が血圧日内変動に及ぼす影響大迫研究

中下愛実, 大久保孝義, 原梓, 菊谷昌浩, 目時弘仁, 宇津木恵, 浅山敬, 井上隆輔, 菅野厚博, 橋本貴尚, 小原拓, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　239-239　2009年10月
出版者・発行元： (NPO)日本高血圧学会
治療中高血圧患者における家庭血圧コントロール改善・悪化の要因に関する検討 J-HOME-Morning研究

小原拓, 小林満, 芝宮拓, 新木貴大, 原梓, 目時弘仁, 浅山敬, 井上隆輔, 菊谷昌浩, 眞野成康, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　263-263　2009年10月
出版者・発行元： (NPO)日本高血圧学会
血漿アルドステロン/レニン活性比と高血圧有病およびNa摂取量との関連家庭血圧を用いた検討(大迫研究)

佐藤倫広, 菊谷昌浩, 原梓, 大久保孝義, 森建文, 目時弘仁, 宇津木恵, 井上隆輔, 浅山敬, 小原拓, 戸恒和人, 星晴久, 佐藤洋, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　318-318　2009年10月
出版者・発行元： (NPO)日本高血圧学会
(プロ)レニン受容体の遺伝子・タンパク質発現心不全モデルでの検討

川村卓也, 戸恒和人, 廣瀬卓男, 森信芳, 原梓, 小原拓, 目時弘仁, 浅山敬, 菊谷昌浩, 大久保孝義, 上月正博, 高橋和広, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　237-237　2009年10月
出版者・発行元： (NPO)日本高血圧学会
アドレノメデュリン2/インターメジン遺伝子多型と無症候性脳血管障害との関連の検討大迫研究

廣瀬卓男, 戸恒和人, 川村卓也, 目時弘仁, 星川美奈子, 原梓, 小原拓, 浅山敬, 菊谷昌浩, 近藤健男, 大久保孝義, 出江紳一, 高橋和広, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　267-267　2009年10月
出版者・発行元： (NPO)日本高血圧学会
妊娠期間中の家庭血圧測定から得られる血行動態データと季節要因の検討 BOSHI研究

目時弘仁, 大久保孝義, 川口麻衣子, 佐藤友里恵, 阿久津好美, 八木橋香津代, 原梓, 小原拓, 菊谷昌浩, 八重樫伸生, 岡村州博, 松原洋一, 森滋, 鈴木雅洲, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　305-305　2009年10月
出版者・発行元： (NPO)日本高血圧学会
正常妊婦における妊娠前肥満度と妊娠中の家庭血圧推移 BOSHI研究

佐藤友里恵, 目時弘仁, 大久保孝義, 川口麻衣子, 阿久津好美, 星川美奈子, 八木橋香津代, 廣瀬卓男, 小原拓, 松原洋一, 八重樫伸生, 岡村州博, 森茂, 鈴木雅洲, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　305-305　2009年10月
出版者・発行元： (NPO)日本高血圧学会
高齢者高血圧患者における早朝家庭血圧管理と降圧治療 J-HOME-Elderly研究

小原拓, 芝宮拓, 新木貴大, 目時弘仁, 浅山敬, 井上隆輔, 菊谷昌浩, 大久保孝義, 眞野成康, 今井潤

日本高血圧学会総会プログラム・抄録集　32回　214-214　2009年10月
出版者・発行元： (NPO)日本高血圧学会
サプリメント摂取者の人口学的特性及び生活習慣に関する研究大迫研究

原梓, 大久保孝義, 小原拓, 坪田恵, 宇津木, 菊谷昌浩, 目時弘仁, 井上隆輔, 浅山敬, 戸恒和人, 星晴久, 細川徹, 佐藤洋, 今井潤

医薬品相互作用研究　33　(1)　7-13　2009年9月
出版者・発行元：医薬品相互作用研究会
ISSN： 0385-5015
Stroke Risk of Blood Pressure Indices Determined by Home Blood Pressure Measurement The Ohasama Study

Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

STROKE　40　(8)　2859-2861　2009年8月

DOI： 10.1161/STROKEAHA.108.546499 　

ISSN： 0039-2499
家庭血圧測定に基づくアムロジピンベシル酸塩の後発医薬品の臨床評価

小原拓, 池田うらら, 新木貴大, 芝宮拓, 大久保孝義, 眞野成康, 今井潤

ジェネリック研究　3　(増刊号)　93-93　2009年6月
出版者・発行元：日本ジェネリック医薬品・バイオシミラー学会
ISSN： 1881-9117
薬剤師における後発医薬品導入における認識

小原拓, 高橋將喜, 高橋則男, 北村哲治, 大久保孝義, 眞野成康, 今井潤

ジェネリック研究　3　(増刊号)　110-110　2009年6月
出版者・発行元：日本ジェネリック医薬品・バイオシミラー学会
ISSN： 1881-9117
CHARACTERISTICS OF UNCONTROLLED HYPERTENSIVE PATIENTS DETERMINED BY MORNING AND EVENING HOME BLOOD PRESSURE MEASUREMENT FROM THE J-HOME STUDY

T. Obara, K. Ito, T. Ohkubo, K. Gonokami, T. Shibamiya, T. Shinki, A. Hara, H. Metoki, K. Asayama, R. Inoue, M. Kikuya, N. Mano, Y. Imai

JOURNAL OF HYPERTENSION　27　S259-S259　2009年6月

ISSN： 0263-6352
HEART RATE, DOUBLE PRODUCT AND SHOCK INDEX IN PREGNANT WOMEN: THE BOSHI STUDY

H. Metoki, T. Ohkubo, M. Kawaguchi, Y. Sato, A. Hara, T. Hirose, T. Obara, K. Asayama, M. Kikuya, K. Yagihashi, Y. Matsubara, K. Okamura, S. Mori, M. Suzuki, Y. Imai

JOURNAL OF HYPERTENSION　27　S228-S228　2009年6月

ISSN： 0263-6352
INFLUENCE OF HOME BLOOD PRESSURE MEASURING CONDITION IN EVENING ON THE MORNING-EVENING HOME BLOOD PRESSURE DIFFERENCE IN TREATED HYPERTENSIVE PATIENTS; THE J-HOME STUDY

T. Obara, K. Ito, T. Ohkubo, K. Gonokami, T. Shibamiya, T. Shinki, M. Nakashita, A. Hara, H. Metoki, K. Asayama, R. Inoue, M. Kikuya, N. Mano, Y. Imai

JOURNAL OF HYPERTENSION　27　S190-S190　2009年6月

ISSN： 0263-6352
SERIAL CHANGE IN SELF-MEASURED BLOOD PRESSURE IN NORMAL PREGNANCY AND POSTPARTUM PERIOD: THE BOSHI STUDY

M. Nishimura, H. Metoki, T. Ohkubo, Y. Watanabe, Y. Sato, M. Kawaguchi, A. Hara, T. Hirose, T. Obara, K. Yagihashi, Y. Matsubara, K. Okamura, S. Mori, M. Suzuki, Y. Imai

JOURNAL OF HYPERTENSION　27　S182-S182　2009年6月

ISSN： 0263-6352
The association between masked hypertension and waist circumference as an obesity-related anthropometric index for metabolic syndrome: the Ohasama study

Kei Asayama, Atsushi Sato, Takayoshi Ohkubo, Akira Mimura, Katsuhisa Hayashi, Masahiro Kikuya, Daisaku Yasui, Atsuhiro Kanno, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

HYPERTENSION RESEARCH　32　(6)　438-443　2009年6月

DOI： 10.1038/hr.2009.37 　

ISSN： 0916-9636
リスク評価と治療計画 (特集新高血圧治療ガイドラインの考え方)

小原拓, 今井潤

調剤と情報　15　(5)　482-487　2009年5月
出版者・発行元：じほう
ISSN： 1341-5212
家庭血圧・随時血圧とアディポサイトカインとの関連大迫研究

林克剛, 浅山敬, 大久保孝義, 菊谷昌浩, 三村亨, 保坂美樹, 原梓, 小原拓, 目時弘仁, 井上隆輔, 星晴久, 佐藤洋, 及川眞一, 今井潤

日本循環器病予防学会誌　44　(2)　98-98　2009年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
家庭血圧測定に基づくアムロジピンベシル酸塩の臨床評価先発医薬品(普通錠2.5mg/5mg)から後発医薬品(アムロジピン錠2.5mg/5mg「明治」)への切り替え

小原拓, 池田うらら, 芝宮拓, 新木貴大, 原梓, 菊谷昌浩, 大久保孝義, 今井潤

日本薬学会年会要旨集　129年会　(4)　308-308　2009年3月
出版者・発行元： (公社)日本薬学会
ISSN： 0918-9823
Office and Out-of-Office Heart Rate and the Development of Metabolic Disorders

Taku Obara, Takayoshi Ohkubo, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　22　(2)　130-130　2009年2月

DOI： 10.1038/ajh.2008.350 　

ISSN： 0895-7061
正常妊娠経過における家庭血圧推移と血圧季節変動 BOSHI研究

目時弘仁, 大久保孝義, 渡邉悠美子, 西村美里, 佐藤友里恵, 川口麻衣子, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 八木橋香津代, 岡村州博, 松原洋一, 森滋, 鈴木雅洲, 今井潤

日本妊娠高血圧学会雑誌　16　101-102　2008年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
正常血圧妊婦における出産前後の自己測定血圧推移 BOSHI研究

西村美里, 目時弘仁, 大久保孝義, 渡邉悠美子, 佐藤友里恵, 川口麻衣子, 八木橋香津代, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 岡村州博, 松原洋一, 森滋, 鈴木雅洲, 今井潤

日本妊娠高血圧学会雑誌　16　172-173　2008年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
正常血圧妊婦における高血圧家族歴と妊娠時の家庭血圧推移 BOSHI研究

渡邉悠美子, 目時弘仁, 大久保孝義, 西村美里, 佐藤友里恵, 川口麻衣子, 八木橋香津代, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 岡村州博, 松原洋一, 森滋, 鈴木雅洲, 今井潤

日本妊娠高血圧学会雑誌　16　174-175　2008年12月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
Seasonal trends of blood pressure during pregnancy in Japan: the Babies and their Parents' Longitudinal Observation in Suzuki Memorial Hospital in Intrauterine Period study

Hirohito Metoki, Takayoshi Ohkubo, Yumiko Watanabe, Misato Nishimura, Yurie Sato, Maiko Kawaguchi, Azusa Hara, Takuo Hirose, Taku Obara, Kei Asayama, Masahiro Kikuya, Katsuyo Yagihashi, Yoichi Matsubara, Kunihiro Okamura, Shigeru Mori, Masakuni Suzuki, Yutaka Imai

JOURNAL OF HYPERTENSION　26　(12)　2406-2413　2008年12月

DOI： 10.1097/HJH.0b013e32831364a7 　

ISSN： 0263-6352
わが国の家庭血圧測定の現状と変化医師の実践と意識"家庭血圧測定の現状に関する調査研究-2"

小原拓, 今井潤, 大久保孝義, 宮川政昭

日本高血圧学会総会プログラム・抄録集　31回　167-167　2008年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧測定と降圧薬使用 J-HOME研究およびJ-HOME追跡(Morning)研究より

小原拓, 大久保孝義, 小林満, 眞野成康, 今井潤

薬剤疫学　13　(Suppl.)　S62-S63　2008年10月
出版者・発行元： (一社)日本薬剤疫学会
ISSN： 1342-0445
降圧治療と関連する遺伝因子のゲノムスキャン HOMED-BP-GENE研究

勝谷友宏, 浅山敬, 大久保孝義, 杉本研, 井上隆輔, 目時弘仁, 小原拓, 石川一彦, 藤澤智巳, 大石充, 荻原俊男, 今井潤, 樂木宏実

日本高血圧学会総会プログラム・抄録集　31回　262-262　2008年10月
出版者・発行元： (NPO)日本高血圧学会
家庭血圧測定 (大規模臨床試験--循環・代謝系を中心に) -- (高血圧)

小原拓, 今井潤

日本臨床　66　191-196　2008年10月
出版者・発行元：日本臨床社
ISSN： 0047-1852
家庭血圧を用いた高血圧発症予測遺伝子多型の同定大迫研究における12年の追跡から

渡邉悠美子, 目時弘仁, 大久保孝義, 勝谷友宏, 田原康玄, 菊谷昌浩, 廣瀬卓男, 杉本研, 浅山敬, 井上隆輔, 原梓, 小原拓, 橋本潤一郎, 名倉潤, 小原克彦, 戸恒和人, 荻原俊男, 樂木宏実, 三木哲郎, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　207-207　2008年10月
出版者・発行元： (NPO)日本高血圧学会
正常妊娠経過における家庭血圧推移と血圧季節変動 BOSHI研究

目時弘仁, 大久保孝義, 渡邉悠美子, 西村美里, 佐藤友里恵, 川口麻衣子, 八木橋香津代, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 岡村州博, 松原洋一, 森滋, 鈴木雅洲, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　359-359　2008年10月
出版者・発行元： (NPO)日本高血圧学会
正常妊婦における出産前後の自己測定血圧推移 BOSHI研究

西村美里, 目時弘仁, 大久保孝義, 渡邉悠美子, 佐藤友里恵, 川口麻衣子, 八木橋香津代, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 岡村州博, 松原洋一, 森滋, 鈴木雅洲, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　359-359　2008年10月
出版者・発行元： (NPO)日本高血圧学会
正常妊婦における高血圧家族歴と妊娠時の血圧推移 BOSHI研究

渡邉悠美子, 目時弘仁, 大久保孝義, 西村美里, 佐藤友里恵, 川口麻衣子, 八木橋香津代, 原梓, 廣瀬卓男, 小原拓, 浅山敬, 菊谷昌浩, 岡村州博, 松原洋一, 森滋, 鈴木雅洲, 今井潤

日本高血圧学会総会プログラム・抄録集　31回　360-360　2008年10月
出版者・発行元： (NPO)日本高血圧学会
Genome-Wide Association Study for the Response to Antihypertensive Medication: HOMED-BP-GENE Study

Tomohiro Katsuya, Kei Asayama, Ryusuke Inoue, Ken Sugimoto, Takayoshi Ohkubo, Hirohito Metoki, Taku Obara, Kazuhiko Ishiakwa, Tomomi Fujisawa, Mitsuru Ohishi, Toshio Ogihara, Yutaka Imai, Hiromi Rakugi

CIRCULATION　118　(18)　S890-S890　2008年10月

ISSN： 0009-7322
Home blood pressure values during normal pregnancy: First report of the babies and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI study)

H. Metoki, T. Ohkubo, Y. Watanabe, M. Nishimura, K. Yagihashi, A. Hara, T. Hirose, T. Obara, M. Kikuya, K. Okamura, Y. Matsubara, S. Mori, M. Suzuki, Y. Imai

JOURNAL OF HYPERTENSION　26　S17-S17　2008年6月

ISSN： 0263-6352
長時間作用型Ca拮抗薬ニルバジピンの家庭血圧および血圧日間変動に与える影響(MORNING study)

加藤哲夫, 小原拓, 菊谷昌浩, 田中宏治, 原梓, 後ノ上健太, 目時弘仁, 大久保孝義, 今井潤

血圧　15　(5)　427-433　2008年5月
出版者・発行元： (株)先端医学社
ISSN： 1340-4598
家庭血圧に基づく仮面高血圧・白衣高血圧と、ウエスト周囲径ならびにBMIに関する横断的検討大迫研究

佐藤敦, 浅山敬, 大久保孝義, 菊谷昌浩, 三村享, 原梓, 小原拓, 目時弘仁, 井上隆輔, 星晴久, 佐藤洋, 坂本尚夫, 今井潤

日本循環器病予防学会誌　43　(1)　39-39　2008年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
患者の服薬コンプライアンスに影響を与える因子に関する薬剤師の認識

小原拓, 田中宏治, 生出泉太郎, 小林満, 原梓, 高橋則男, 高橋將喜, 大久保孝義, 今井潤

日本薬学会年会要旨集　128年会　(4)　176-176　2008年3月
出版者・発行元： (公社)日本薬学会
ISSN： 0918-9823
Proposal of a risk-stratification system for the Japanese population based on blood pressure levels: the Ohasama study.

Asayama Kei, Ohkubo Takayoshi, Sato Atsushi, Hara Azusa, Obara Taku, Yasui Daisaku, Metoki Hirohito, Inoue Ryusuke, Kikuya Masahiro, Hashimoto Junichiro, Hoshi Haruhisa, Satoh Hiroshi, Imai Yutaka

Hypertens Res　31　(7)　1315-1322　2008年

DOI： 10.1291/hypres.31.1315 　

ISSN： 0916-9636 1348-4214
外来患者における後発医薬品の認識に関するアンケート調査

田中宏治, 小原拓, 大久保孝義

ジェネリック研究　1　(2)　92-101　2007年12月
出版者・発行元：日本ジェネリック医薬品学会
ISSN： 1881-9117
大迫研究(家庭血圧の重要性を世界に発信した) 家庭血圧測定の活用

小原拓, 大久保孝義, 今井潤

BIO Clinica　22　(11)　996-1000　2007年10月
出版者・発行元： (株)北隆館
ISSN： 0919-8237
一般地域住民における一般用医薬品・サプリメント使用に関する実態調査

原梓, 大久保孝義, 菊谷昌浩, 佐藤理恵, 小原拓, 宇津木恵, 目時弘仁, 佐藤洋, 今井潤

Health Sciences　23　(4)　303-303　2007年10月
出版者・発行元：日本健康科学学会
ISSN： 0911-7024
How many times should we ask subjects to measure blood pressure at home on each occasion?

Yutaka Imai, Taku Obara, Takayoshi Ohkubo

JOURNAL OF HYPERTENSION　25　(10)　1987-1991　2007年10月

ISSN： 0263-6352
両親の長寿は子の低い血圧と関連する大迫研究

渡邉悠美子, 目時弘仁, 大久保孝義, 廣瀬卓男, 菊谷昌浩, 浅山敬, 井上隆輔, 森戸里衣子, 原梓, 小原拓, 星晴久, 橋本潤一郎, 戸恒和人, 今井潤

日本高血圧学会総会プログラム・抄録集　30回　271-271　2007年10月
出版者・発行元： (NPO)日本高血圧学会
Stroke Risk in Systolic and Combined Systolic and Diastolic Hypertension Determined Using Ambulatory Blood Pressure. The Ohasama Study

Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

American Journal of Hypertension　20　(10)　1125-1131　2007年10月

DOI： 10.1016/j.amjhyper.2007.04.017 　

ISSN： 0895-7061
29-A3-14-5 降圧薬服用コンプライアンス不良者の特性及び生活習慣に関する研究(調剤・服薬指導・薬剤管理指導,社会の期待に応える医療薬学を)

原梓, 大久保孝義, 菊谷昌浩, 小原拓, 田中宏治, 目時弘仁, 宇津木恵, 井上隆輔, 浅山敬, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

日本医療薬学会年会講演要旨集　17　190-190　2007年9月1日
出版者・発行元：日本医療薬学会
Definition of masked hypertension

Taku Obara, Takayoshi Ohkubo, Kei Asayama, Hirohito Metoki, Yutaka Imai

JOURNAL OF HYPERTENSION　25　(7)　1511-1512　2007年7月

ISSN： 0263-6352
Usefulness of the vasodilator minoxidil in resistant hypertension - Reply

Taku Obara, Takayoshi Ohkubo, Takuya Oikawa, Yutaka Imai

JOURNAL OF HYPERTENSION　25　(5)　1103-1103　2007年5月

ISSN： 0263-6352
Plasma fibrinogen, ambulatory blood pressure, and silent cerebrovascular lesions: The Ohasama study

Yoko Aono, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Takeo Kondo, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoriko Shintani, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

Arteriosclerosis, Thrombosis, and Vascular Biology　27　(4)　963-968　2007年4月

DOI： 10.1161/01.ATV.0000258947.17570.38 　

ISSN： 1079-5642
Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality in Ohasama, Japan

Masahiro Kikuya, Jan A. Staessen, Takayoshi Ohkubo, Lutgarde Thijs, Hirohito Metoki, Kei Asayama, Taku Obara, Ryusuke Inoue, Yan Li, Eamon Dolan, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Ji-Guang Wang, Eoin O'Brien, Yutaka Imai

Stroke　38　(4)　1161-1166　2007年4月

DOI： 10.1161/01.STR.0000259604.67283.69 　

ISSN： 0039-2499
高血圧患者における服薬コンプライアンスの現状

田中宏治, 生出泉太郎, 小原拓, 高橋將喜, 高橋則男, 大久保孝義, 今井潤

日本薬学会年会要旨集　127年会　(3)　94-94　2007年3月
出版者・発行元： (公社)日本薬学会
ISSN： 0918-9823
GEの競争政策上の評価 (特集ジェネリック医薬品(GE)の到来--GEを理解するために) -- (GEにおける医療経済と医療制度)

小原拓, 小林慎

治療　89　(3)　527-531　2007年3月
出版者・発行元：南山堂
ISSN： 0022-5207
Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study

Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takanao Hashimoto, Toshiya Harasawa, Yoko Aono, Harunori Otani, Kazushi Tanaka, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

Journal of Hypertension　25　(2)　321-327　2007年2月

DOI： 10.1097/HJH.0b013e3280115bbf 　

ISSN： 0263-6352
The current status of heart rate measured at home among treated hypertensive patients: The Japan home versus office blood pressure measurement evaluation (J-HOME) study

Rie Komai, Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Takuya Oikawa, Kayo Murai, Tsuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

JOURNAL OF HYPERTENSION　24　266-266　2006年12月

ISSN： 0263-6352
Ambulatory blood pressure, blood pressure variability and the prevalence of carotid atherosclerosis: The ohasama study

Yoriko Shintani, Masahiro Kikuya, Azusa Haral, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Yoko Aono, Takanao Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

JOURNAL OF HYPERTENSION　24　122-123　2006年12月

ISSN： 0263-6352
Development of new electronic drug compliance-monitoring device for one dose package (HCM-100)

Taku Obara, Takayoshi Ohkubo, Kayo Murai, Rie Komai, Kouji Tanaka, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

JOURNAL OF HYPERTENSION　24　220-220　2006年12月

ISSN： 0263-6352
Ambulatory blood pressure, plasma fibrinogen, and silent cerebrovascular lesions: The ohasama study

Yoko Aono, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Takeo Kondo, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoriko Shintani, Junichiro Hashirnoto, Kazuhito Totsune, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

JOURNAL OF HYPERTENSION　24　212-212　2006年12月

ISSN： 0263-6352
Cost-effectiveness of home blood pressure

Hidefumi Fukunaga, Takayoshi Ohkubo, Taku Obara, Miwa Nakagawa, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Makoto Kobayashi, Yutaka Imai

JOURNAL OF HYPERTENSION　24　87-88　2006年12月

ISSN： 0263-6352
Comparison of stroke risk among subtypes of hypertension determined by 24-hour ambulatory blood pressure monitoring: The Ohasama study

Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

JOURNAL OF HYPERTENSION　24　117-117　2006年12月

ISSN： 0263-6352
Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality: Results from the ohasama study

Masahiro Kikuya, Jan A. Staessen, Takayoshi Ohkubo, Lutgarde Thijs, Hirohito Metoki, Kei Asayama, Taku Obara, Ryusuke Inoue, Yan Li, Eamon Dolan, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

JOURNAL OF HYPERTENSION　24　171-171　2006年12月

ISSN： 0263-6352
Detection of silent cerebrovascular lesions in subjects with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study

Azusa Hara, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Yoko Aono, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoriko Shintani, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

JOURNAL OF HYPERTENSION　24　267-267　2006年12月

ISSN： 0263-6352
Factors affecting day-by-day variability of self-measured blood pressure at home: The Ohasama study

Tetsuo Kato, Masahiro Kikuya, Takayoshi Ohkubo, Azusa Hara, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Satoh Hiroshi, Yutaka Imai

JOURNAL OF HYPERTENSION　24　87-87　2006年12月

ISSN： 0263-6352
Home and office blood pressure control among elderly hypertensive patients without calcium channel blockers before and after JSH2004

Taku Obara, Takayoshi Ohkubo, Rie Komai, Kayo Murai, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

JOURNAL OF HYPERTENSION　24　379-379　2006年12月

ISSN： 0263-6352
The current usage of diuretics among hypertensive patients in Japan: the Japan home versus office blood pressure measurement evaluation (J-HOME) study

Kayo Murai, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Masahiro Kikuya, Ryusuke Inoue, Kei Asayama, Takuya Oikawa, Rie Komai, Tuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

JOURNAL OF HYPERTENSION　24　260-260　2006年12月

ISSN： 0263-6352
Parental longevity and home blood pressure values in adult offspring: The Ohasama study 査読有り

Metoki Hirohito, Ohkubo Takayoshi, Watanabe Yumiko, Hirose Takuo, Kikuya Masahiro, Asayama Kei, Inoue Ryusuke, Hara Azusa, Obara Taku, Hoshi Haruhisa, Hashimoto Junichiro, Totsune Kazuhito, Imai Yutaka

JOURNAL OF HYPERTENSION　24　241　2006年12月

ISSN： 0263-6352
Combination of decreased kidney function and pre-hypertension affect mortality risk in a general Japanese population: The Ohasama study 査読有り

Metoki Hirohito, Ohkubo Takayoshi, Nakayama Msaaki, Terawaki Hiroyuki, Kikuya Masahiro, Asayama Kei, Hara Azusa, Hirose Takuo, Obara Taku, Hashimoto Junichiro, Totsune Kazuhito, Hoshi Haruhisa, Ito Sadayoshi, Imai Yutaka

JOURNAL OF HYPERTENSION　24　78-79　2006年12月

ISSN： 0263-6352
Predicting stroke using 4 ambulatory blood pressure monitoring-derived blood pressure indices: The Ohasama study

Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

Hypertension　48　(5)　877-882　2006年11月

DOI： 10.1161/01.HYP.0000242285.83728.ee 　

ISSN： 0194-911X
Introversion associated with large differences between screening blood pressure and home blood pressure measurement: The Ohasama study

Atsushi Hozawa, Takayoshi Ohkubo, Taku Obara, Hirohito Metoki, Masahiro Kikuya, Kei Asayama, Kazuhito Totsune, Junichiro Hashimoto, Haruhisa Hoshi, Yumiko Arai, Hiroshi Satoh, Toru Hosokawa, Yutaka Imai

Journal of Hypertension　24　(11)　2183-2189　2006年11月

DOI： 10.1097/01.hjh.0000249695.81241.35 　

ISSN： 0263-6352
一般地域住民におけるサプリメント摂取者の人口学的特性及び生活習慣に関する研究

原梓, 大久保孝義, 菊谷昌浩, 小原拓, 芝崎貴子, 目時弘仁, 井上隆輔, 浅山敬, 橋本潤一郎, 戸恒和人, 星晴久, 細川徹, 佐藤洋, 今井潤

Health Sciences　22　(4)　606-606　2006年10月
出版者・発行元：日本健康科学学会
ISSN： 0911-7024
Prognostic significance of night-time, early morning, and daytime blood pressures on the risk of cerebrovascular and cardiovascular mortality: The Ohasama Study

Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Taku Obara, Azusa Hara, Takuo Hirose, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

Journal of Hypertension　24　(9)　1841-1848　2006年9月

DOI： 10.1097/01.hjh.0000242409.65783.fb 　

ISSN： 0263-6352
高血圧患者における心拍数管理の重要性とβ遮断薬の使用実態大迫研究,J-HOME(The Japan Home vs.Office blood pressure Measurement Evaluation)研究からの考察

小原拓, 駒井理恵, 大久保孝義, 今井潤

血圧　13　(8)　921-927　2006年8月
出版者・発行元： (株)先端医学社
ISSN： 1340-4598
治療中高齢高血圧患者における家庭血圧管理の現状 J-HOME研究グループを代表して

小原拓, 大久保孝義, 今井潤

日本老年医学会雑誌　43　(Suppl.)　132-132　2006年5月
出版者・発行元： (一社)日本老年医学会
ISSN： 0300-9173
家庭血圧重視の立場から (診療controversy--medical decision makingのために家庭血圧と24時間血圧を高血圧診療にどのように生かすか?)

芝崎貴子, 小原拓, 今井潤

内科　97　(5)　901-905　2006年5月
出版者・発行元：南江堂
ISSN： 0022-1961
Masked hypertension and white-coat hypertension prognosis - Reply

T Ohkubo, M Kikuya, H Metoki, K Asayama, T Obara, J Hashimoto, K Totsune, H Hoshi, H Satoh, Y Imai

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　47　(10)　2127-2128　2006年5月

DOI： 10.1016/j.jacc.2006.02.035 　

ISSN： 0735-1097
Prognosis of "masked" hypertension vs "white-coat" hypertension

Takayoshi Ohkubo, Takayoshi Ohkubo, Takayoshi Ohkubo, Masahiro Kikuya, Masahiro Kikuya, Hirohito Metoki, Hirohito Metoki, Hirohito Metoki, Kei Asayama, Kei Asayama, Kei Asayama, Taku Obara, Taku Obara, Junichiro Hashimoto, Junichiro Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Kazuhito Totsune, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Hiroshi Satoh, Hiroshi Satoh, Yutaka Imai

Cardiology Review　23　23-27　2006年4月1日

ISSN： 1092-6607
一包化調剤対応服薬コンプライアンス計(HCM-100)の開発

駒井理恵, 小原拓, 大久保孝義, 村井華代, 菊谷昌浩, 浅山敬, 目時弘仁, 橋本潤一郎, 戸恒和人, 今井潤

日本薬学会年会要旨集　126年会　(2)　158-158　2006年3月
出版者・発行元： (公社)日本薬学会
ISSN： 0918-9823
PJ-544 Effectiveness of Nilvaldipine for Morning Hypertension by Home Blood Pressure (MORNING Study)(Hypertension, clinical-8 (M) PJ92,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Ohkubo Takayoshi, Obara Taku, Asayama Kei, Metoki Hirohito, Hashimoto Junichiro, Imai Yutaka

Circulation journal : official journal of the Japanese Circulation Society　70　624-624　2006年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline: The Ohasama study

Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

Hypertension　47　(2)　149-154　2006年2月

DOI： 10.1161/01.HYP.0000198541.12640.0f 　

ISSN： 0194-911X
White-coat hypertension and progression to home hypertension

Takashi Ugajin, Atsushi Hozawa, Takayoshi Ohkubo, Takayoshi Ohkubo, Kei Asayama, Kei Asayama, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Hirohito Metoki, Haruhisa Hoshi, Junichiro Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Satoh, Ichiro Tsuji, Yutaka Imai, Yutaka Imai

Cardiology Review　23　18-22　2006年2月1日

ISSN： 1092-6607
家庭血圧によるニルバジピン(ニバジール)の早朝高血圧に対する有用性の検討 MORNING study

小原拓, 大久保孝義, 芝崎貴子, 菊谷昌浩, 今井潤

Therapeutic Research　27　(1)　99-114　2006年1月
出版者・発行元：ライフサイエンス出版(株)
ISSN： 0289-8020
家庭血圧測定の意義 (特集高血圧--管理と予防)

小原拓, 今井潤

セフィーロ　(4)　38-41　2006年
出版者・発行元：メデカジャパン・ラボラトリー
ISSN： 1880-5167
Prognosis of "masked" hypertension and "white-coat" hypertension detected by 24-h ambulatory blood pressure monitoring: 10-Year follow-up from the Ohasama study

Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

Journal of the American College of Cardiology　46　(3)　508-515　2005年8月2日

DOI： 10.1016/j.jacc.2005.03.070 　

ISSN： 0735-1097
Isolated uncontrolled hypertension at home and in the office among treated hypertensive patients from the J-home study

T Obara, T Ohkubo, J Funahashi, M Kikuya, K Asayama, H Metoki, T Oikawa, J Hashimoto, K Totsune, Y Imai

JOURNAL OF HYPERTENSION　23　S34-S34　2005年6月

ISSN： 0263-6352
Isolated Uncontrolled Hypertension at Home and in the Office among Treated Hypertensive Patients : from the J-HOME Study(Hypertension, Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Obara Taku, Ohkubo Takayoshi, Asayama Kei, Metoki Hirohito, Hashimoto Junichiro, Imai Yutaka

Circulation journal : official journal of the Japanese Circulation Society　69　267-268　2005年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
Prognostic Significance of Night-time, Early Morning and Daytime Blood Pressures on the Risks of Cerebro and Cardiovascular Mortality(Hypertension, Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Metoki Hirohito, Ohkubo Takayoshi, Asayama Kei, Obara Taku, Hashimoto Junichiro, Imai Yutaka

Circulation journal : official journal of the Japanese Circulation Society　69　268-269　2005年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
Ambulatory blood pressure and 10-year risk of cardiovascular and noncardiovascular mortality: The Ohasama study

Masahiro Kikuya, Takayoshi Ohkubo, Kei Asayama, Hirohito Metoki, Taku Obara, Shin Saito, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

Hypertension　45　(2)　240-245　2005年2月

DOI： 10.1161/01.HYP.0000152079.04553.2c 　

ISSN： 0194-911X
Plasma Fibrinogen and Silent Cerebrovascular Lesions

青野蓉子, 菊谷昌浩, 原梓, 大久保孝義, 近藤健男, 浅山敬, 井上隆輔, 目時弘仁, 小原拓, 新谷依子, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 出江伸一, 今井潤

日本循環器病予防学会誌　40　(3)　181-189　2005年
出版者・発行元：社団法人日本循環器管理研究協議会
DOI： 10.11381/jjcdp2001.40.181 　

ISSN： 1346-6267

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[Background and purpose] Silent cerebrovascular lesions are associated with an increased risk of stroke. Although the incidence of cerebral hemorrhage has decreased in Japan, prevalence of cerebral infarction has not decreased. Fibrinogen is a major determinant of plasma viscosity. It is possible that elevated fibrinogen level is associated with the risk of cerebral infarction. We conducted a cross-sectional study to determine the association between plasma fibrinogen and cerebrovascular lesions in a general population.<BR>[Methods] The study population consisted of 662 subjects (32.2% men, mean age 66.6 ± 5.3 years, mean plasma fibrinogen 299.8 ± 63.5 mg/dl) from a general population of rural Japanese community, Ohasama. We evaluated the association between plasma fibrinogen and silent cerebrovascular lesions [number of lacunar infarction and extent of periventricular hyperintensity (PVH)] detected by MRI.<BR>[Results] Fibrinogen levels were significantly higher in subjects with multiple lacunar infarctions. Each 1SD (63.5 mg/dl) increase in fibrinogen was significantly associated with an increase in the risk of lacunar infarction (OR=1.29, 95% CI : 1.09-1.53) after adjustment for age, sex, smoking status, drinking status, use of antihypertensive medication, BMI, 24-h ambulatory blood pressure (24-h ABP), and a history of hypercholesterolemia, diabetes mellitus or atrial fibrillation. Twenty-four hour ABP was also significantly and independently associated with lacunar infarction. Even when 24-h ABP values were within the normal range (<135/80 mmHg), elevated fibrinogen levels were associated with an increased risk of lacunar infarction. There was no association between fibrinogen and PVH.<BR>[Conclusion] The present results demonstrated that fibrinogen was strongly associated with risk of lacunar infarction, suggesting that fibrinogen is an independent risk factor or predictor for lacunar infarction.
【白衣高血圧と仮面高血圧】白衣高血圧,仮面高血圧の定義と頻度

小原拓, 大久保孝義, 今井潤

血圧　11　(8)　783-787　2004年8月
出版者・発行元： (株)先端医学社
ISSN： 1340-4598

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 15

バイオバンクデータを用いた前置胎盤のオミクス解析と臨床応用

濱田裕貴, 小原拓, 齋藤昌利, 岩間憲之, 富田芙弥

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2025年4月1日～ 2029年3月31日
不妊治療・妊娠高血圧症候群と児の心血管・代謝機能や神経発達との関連についての研究

石黒真美, 小原拓

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2024年4月1日～ 2028年3月31日
CXCR4システム・口腔マイクロバイオームに着目した薬剤関連顎骨壊死の発症予防戦略

八木達也, 玉原亨, 川上純一, 小原拓

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Hamamatsu University School of Medicine

2024年4月1日～ 2027年3月31日
家族歴・産科合併症既往を考慮した高血圧等の母児の予後の検討

石黒真美, 目時弘仁, 小原拓

2021年4月1日～ 2024年3月31日

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本研究では、全国規模の医療情報データベース及び三世代に渡る家族参加型の出生ゲノムコホート研究を用いて、妊娠高血圧症候群、妊娠糖尿病、妊娠中の脂質異常症の要因および母児の予後への影響を明らかにすることを目的としている。 2021年度は、東北メディカル・メガバンク計画三世代コホート調査のデータを基に、妊娠高血圧症候群の既往と産後約3年での血圧値との関連を検討した。共分散分析の結果、妊娠高血圧症候群既往のある女性は、既往のない女性に比べて、産後3年での血圧値が高かった。多変量ロジスティック回帰分析でも、妊娠高血圧症候群の既往は、産後3年での高血圧との関連も認めた（オッズ比5.67、95 %信頼区間4.34-7.41）。また、初産婦、経産婦で妊娠高血圧症候群既往なし、既往ありの3群にわけ、それぞれの群において直近の妊娠中の妊娠高血圧症候群を発症有無で産後の血圧値を比較したところ、いずれの群でも直近の妊娠中に妊娠高血圧症候群を発症した女性の方が産後3年での血圧値が高かった。しかしながら、過去に妊娠高血圧症候群の既往がある女性は、直近の妊娠中に妊娠高血圧症候群を発症しなかったとしても、既往のない経産婦と比較すると血圧値が高かったことから、妊娠高血圧症候群の発症回数に関わらず、妊娠高血圧症候群発症そのものが産後数年での血圧値や高血圧に影響する可能性が示唆された。全国規模の医療情報データベースにおいても、構造の理解を深め、両親の高血圧有病状況と子どもの高血圧有病状況の関連について検討を進めた。
降下性縦隔炎の治療法構築と地域包括医療計画への提言：医療ビッグデータを用いた解析

日高浩史, 岩井大, たら澤邦男, 藤森研司, 小原拓, 阪上智史

2020年4月1日～ 2023年3月31日

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深頸部感染症は降下性縦隔炎や敗血症など致死的な合併症や、嚥下機能回復が遅延することがある。今回、医療大規模データを用いて全国レベルでの深頸部感染症における生命予後、術後の経口摂取回復が遅延する因子について分析した。 2012～6年のDPCデータベースからスクリーニングを行い、4949例に対し、死亡退院に関与するリスクについてロジステック回帰分析を行った。さらに生存退院した4791例に対し、経口摂取回復が遅延する因子について解析した。年齢（75歳以上）、人工呼吸器使用と抗菌薬の使用期間の3つのみが、2つのアウトカムともに統計学的に有意なリスク因子であった。一方、縦隔炎合併、複数回の排膿術は経口摂取回復遅延に対してのみ有意な因子であった。近年、胸腔鏡での排膿術を併用することで、降下性縦隔炎の生存率が向上していると予想されるが、組織の瘢痕などで嚥下機能回復が遅延するリスクを踏まえた治療プランニングが必要と考えられる。本研究成果は、欧文誌Head and Neckに掲載された（Hidaka H, et al: Identification of risk factors for mortality and delayed oral dietary intake in patients with open drainage due to deep neck infections: Nationwide study using a Japanese inpatient database. Head Neck. 43(7):2002-2012, 2021)。
小児における向精神薬使用の安全性評価の推進

小原拓

2019年4月1日～ 2022年3月31日

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株式会社JMDCが保有する健康保険組合のClaims Databaseに基づいて、小児における注意欠如・多動性障害（ADHD）に対する治療薬であるメチルフェニデート徐放錠：OROS-MPH、アトモキセチン；ATX）と心血管系疾患リスクとの関連を推定することを目的に、7,773人の小児を対象とした後ろ向きコホート研究を実施してきた。これまでに、心筋梗塞、脳卒中、不整脈、高血圧症などをアウトカムとするCOX比例ハザードモデル解析によって、ADHD治療薬処方群における心血管系イベントのリスクが高値であったことなどを明らかにした。更に、アウトカムの一つである不整脈の重症度を考慮した感度解析を行い、対象者数が減少したものの、いずれの感度解析においてもハザード比の点推定値は1を超えており、ADHD治療薬処方群で不整脈と正に関連していた。株式会社Medical Data Visionが保有するDPC病院のAdministrative Databaseに基づいて、てんかんの小児外来患者（0～17歳）に対する抗てんかん薬の処方動向を評価した。女児では、バルプロ酸とカルバマゼピンがそれぞれ37.9％から26.8％、24.8％から15.8％に減少し、逆にレベチラセタムの処方の割合は6.4%から28.2%に増加していた。男児では、バルプロ酸とカルバマゼピンがそれぞれ36.6％から32.2％、26.4％から16.9％に減少し、レベチラセタムの処方比率は5.6%から23.0%に増加していた。全体としてバルプロ酸とカルバマゼピンの処方割合は減少し、レベチラセタムの処方割合が増加していた。日本の小児てんかん外来患者における抗てんかん薬処方の傾向は、より最近に発売された抗てんかん薬にシフトしていることが明らかとなった。
妊婦の医薬品使用と児の先天奇形発症に関連する環境・遺伝要因の解明

西郡秀和, 小原拓, 栗山進一

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Fukushima Medical University

2019年4月1日～ 2022年3月31日

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妊婦の医薬品使用と児の発達に関して、大規模レセプトデータベースを用いて検討を行った。各妊婦の妊娠開始日および出産日は、我々が構築したアルゴリズムおよび児の出生年月を用いた。レセプトデータベースに登録されている3万人以上の妊婦を対象とした。①ドンペリドンを含む消化管運動改善薬の妊娠初期の処方、②アムロジピンやメチルドパを含む降圧薬の妊娠初期の処方、③免疫抑制剤であるカルシニューリン阻害薬の妊娠期の処方と、児のmajor congenital malformationとの関連は認められなかった。
表現型クラスター化と超高次元変数選択法による自閉症スペクトラム障害の原因解明

栗山進一, 田宮元, 呉繁夫, 瀬戸俊之, 吉川貴仁, 山中千鶴, 松原博子, 永井雅人, 小原拓

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2016年4月1日～ 2019年3月31日

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ビタミンB6反応性を予測する因子を検討した。統計学的検定及び機械学習アルゴリズムを適用したところ、音への過敏と不器用さを同時に有し、血中グルタミン濃度が低値であることがビタミンB6反応性を示唆することを見出した。さらに、Simons Simplex Collectionの登録者のデータを用いて、Genome Wide Association Studyを行ったところ、全症例 vs 対照では有意な遺伝子座は観察されなかった。一方、機械学習によって表現型をクラスター毎に分けたのちに行った解析では、有意なSNPが複数観察された。
妊婦および小児におけるインフルエンザワクチンの有効性・安全性評価

小原拓

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2015年4月1日～ 2018年3月31日

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本邦において、妊婦および小児における適切なインフルエンザワクチン接種の普及を推進するためには、本邦独自の成果に基づいて、これらの疑問や不安を払しょくする必要がある。そこで、複数の研究基盤に基づいて、インフルエンザワクチン接種の有効性・安全性の評価を試みた。BOSHI研究・エコチル調査においては、妊婦のインフルエンザワクチンの接種状況把握のための情報収集および出生児の追跡調査を実施した。医師会調査においては、経年的に児におけるインフルエンザワクチンの接種状況、インフルエンザ感染状況、副反応の発生状況を調査し、シーズン間で大きな差は生じていないことを明らかにした。
大規模コホート研究およびレセプトを基盤とした両親の産後うつ要因と弊害の新規抽出

西郡秀和, 栗山進一, 吉田敬子, 八重樫伸生, 小原拓, 西郡俊絵, 菅原準一

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2012年4月1日～ 2015年3月31日

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宮城県と岩手県の被災地における東日本大震災と関連した産後うつ（EPDS9点以上）因子は「津波への遭遇」「自宅の破壊・住居の変更」「環境不満」であった。震災後の宮城県にける産後うつとボンディング障害の産後1か月の検討では、エジンバラ質問票EPDS9点以上：母親11.8％vs父親8.4％、赤ちゃんの気持ち質問票7点以上：母親3.5％vs父親6.3％であった。株式会社日本医療データセンターのレセプトデータを用いて、母親8,020名の妊娠期間の特定を可能にした。向精神薬の処方件数は妊娠期3.43%、分娩期10.3%、産後1年以内0.59％であった。
妊娠中のサプリメント摂取が妊娠経過、児の発育、母子の疾患発症へ与える影響の解明

小原拓

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2012年4月1日～ 2015年3月31日

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本研究の目的は、既存のコホート研究に基づいて、妊娠中のサプリメント摂取が妊娠経過、児の発育、母子の疾患発症との関連を明らかにすることである。妊娠中を通して最も多くの妊婦が使用していたサプリメントは、エコチル追加調査対象者（初期3,600名、中後期2,765名）・BOSHI研究対象者（初期122名、中後期82名）共に葉酸であった（20.2－35.4％）。葉酸の次に多く使用されていたサプリメントは、ビタミンB群やミネラルであった。本研究実施により、大規模妊婦集団において、妊娠中のサプリメント摂取とより長期間の追跡に基づく将来の母子の各種疾患の発症や健康との関連を検討するための基盤が構築された。
脳心血管疾患危険因子に対する薬物治療の医療薬学・経済学的検討

小原拓

2008年～ 2010年

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降圧治療中患者に関する追跡研究(J-HOME-Morning/Elderly研究)は、最終的な追跡率が80%を超え、すでに回収・データ入力を終えていた1次・2次調査の結果は、「降圧治療中患者における家庭血圧管理と腎機能低下に関する縦断的検討:J-HOME-Morning研究」との演題名で発表した。また、今年は、日本全国の降圧治療中患者の家庭血圧管理状況と脳心血管疾患の発症・死亡の関連について報告する。高血圧治療の第一選択薬および家庭血圧の降圧目標に関する大規模介入試験であるHOMED-BP研究は、2010年5月で登録患者の追跡期間を終了とし、対象者の約94%の予後に関する情報が得られた。家庭血圧値に基づく降圧治療における降圧目標に関する最終結果を、2011年の第33回日本高血圧学会総会において報告する。その他、既存研究の基盤に基づいて、慢性疾患治療薬に関する医療薬学的研究を行い、順調に結果の発表及び論文化を行った。慢性疾患に対する治療に関する情報に基づいて、医療経済的評価を行うという新規研究については、東北大学病院の処方履歴およびレセプトデータの利用手続きが間に合わなかったため、アンジオテンシンII受容体拮抗薬(ARB)高用量群とARBと利尿薬の合剤群で家庭血圧の降圧効果を比較したJ-HOME-AI研究のデータを用いて、薬剤経済学的検討を行い、ARB高用量を用いる治療に比べて、合剤による高血圧治療は、生存年数を短縮させることなく医療費の削減につながることを明らかにした。
仮面高血圧の頻度、治療･予後競争的資金

2003年～ 2008年
The prevalence treatment, act prognosis of masked hypertension 競争的資金

制度名：Basic Research Promotion Service for Health and Medical Field

2003年～ 2008年
降圧治療中の高血圧患者における血圧管理および降圧薬使用と予後に関する追跡研究

小原拓

2006年～ 2007年

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2003年に行われた横断的調査(J-HOME研究)より、家庭血圧測定を行っている高血圧患者の血圧管理が、そのほかの高血圧患者に比べ良好であったことや、家庭血圧同様、予後予測能が高いことが報告されている早朝・就寝前家庭心拍数の規定因子、外的刺激に対する反応性の指標の一つである白衣現象(外来血圧-家庭血圧)の規定因子を明らかにし、英文雑誌に報告した。また、第一次調査対象者のベースラインデータを固定し、ベースラインにおける対象者の外来血圧および家庭血圧管理状況、脳心血管疾患発症リスク因子、服用降圧薬剤の数・種類、および12誘導心電図所見に関する横断的検討を行い、その一部にあたる、高齢者高血圧患者の各種血圧管理状況等を欧州高血圧学会において発表した。また、2003年に行われた横断的調査(J-HOME研究)対象者との比較により、日本高血圧学会による高血圧治療ガイドライン(JSH2004)発表後の降圧薬使用状況、対象者の外来血圧・家庭管理状況、および患者の血圧管理状況に対する主治医の認識の変化を検討し、JSH2004発表後に、服用降圧薬数は増加し、各種血圧管理は改善し、患者の血圧に対する主治医の評価は、JSH2004発表後に厳格化しており、厳格な降圧を推奨したJSH2004が医療現場の降圧治療に影響している可能性を、日本高血圧学会で発表し、本報告は高得点演題に選出された。現在、JSH2004が日本の高血圧治療に与えた影響について、論文作成中である。さらに、2006年10月より開始されていた第二次調査の終了に伴い、第二次調査において報告された各種イベントに関する詳細なイベント調査を開始すると同時に、第二次調査の結果をニュースレターとして参加施設ヘフィードバックし、2008年夏に開始予定の第三次調査へのモチベーションの維持に努めた。

︎全件表示 ︎最初の5件までを表示