Details of the Researcher

PHOTO

Taku Obara
Section
Tohoku Medical Megabank Organization
Job title
Professor
Degree

Research Interests 3

  • Pharmacoepidemiology

  • 臨床薬学

  • Epidemiology

Research Areas 2

  • Life sciences / Hygiene and public health (non-laboratory) /

  • Life sciences / Clinical pharmacy /

Papers 636

  1. Risk of Major Congenital Malformations Associated With the First-Trimester Exposure to Antipsychotics: A Large Claims Database Study. International-journal

    Ryo Obara, Takamasa Sakai, Tomofumi Ishikawa, Kei Morishita, Motohiko Adomi, Azusa Hara, Saya Kikuchi, Natsuko Kobayashi, Noriyuki Iwama, Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Nariyasu Mano, Shinichi Kuriyama, Taku Obara

    Pharmacology research & perspectives　14　(2)　e70231　2026/04

    DOI： 10.1002/prp2.70231 　

    More details Close

    This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with first-trimester exposure to antipsychotics, using a large claims database in Japan. This retrospective cohort study was based on data from a large claims database in Japan. We used a large claims database from 2010 to 2019. Dates of pregnancy onset and delivery were estimated using the developed algorithms. Overall MCMs were defined according to the International Classification of Diseases, 10th revision codes. To address confounding by indication, the risk of MCM in relation to first-trimester antipsychotic use was evaluated among pregnant women with psychiatric disorders diagnosed before the end of the first-trimester. We compared the prevalence of MCMs among infants born to pregnant women with or without first-trimester exposure to antipsychotics and estimated the weighted odds ratios (wORs) using propensity-score overlap weights. The prevalence of psychiatric diagnoses before the end of the first-trimester was 6291 women among the 91 390 who delivered between 2010 and 2019. Among the 6291 diagnosed with psychiatric disorders, 317 were exposed to any antipsychotics during the first-trimester of pregnancy. The prevalence of overall MCMs among live births was 411 (6.9%) among women unexposed to any antipsychotics and 24 (7.6%) among those exposed. The first-trimester exposure to any antipsychotics was not significantly associated with overall MCMs when wORs were calculated using propensity-score overlap weights (wOR 1.144, 95% confidence intervals 0.727-1.799). Exposure to any antipsychotics during the first-trimester of pregnancy was not associated with an increased risk of overall MCMs in infants.

  2. Association between exposure to Kampo medicines containing Ephedra and major congenital malformations: A Japanese administrative claims database study Peer-reviewed

    Satoko Suzuki, Ryutaro Arita, Taku Obara, Tomofumi Ishikawa, Tadaharu Kunitoki, Takamasa Sakai, Aoi Noda, Genki Shinoda, Mami Ishikuro, Masatsugu Orui, Shinichi Kuriyama, Minoru Ohsawa, Ken Haneda, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

    Traditional & Kampo Medicine　13　(1)　2026/03/25

    Publisher: Wiley

    DOI： 10.1002/tkm2.70049 　

    ISSN： 2053-4515

    eISSN： 2053-4515

    More details Close

    ABSTRACT Aim Traditional Japanese (Kampo) medicines containing ephedra (KE) are prescribed for cold during pregnancy; however, detailed safety information on their use in pregnant women is lacking. This study aimed to clarify the association between prescription of KE during the first trimester of pregnancy and major congenital malformations (MCMs) in newborns. Methods Data from a large Japanese administrative claims database were analyzed: we included records of pregnant women who continued to be covered in the same health insurance society from 3 months before pregnancy until delivery, who gave birth between 2010 and 2019; the selected records included data relating to the infants until first year from birth. Pregnant women who were prescribed acetaminophen, commonly used to treat colds, in the first trimester of pregnancy and their infants were treated as the controls in our analysis. Results Of 75,398 infants, 4607 (6.1%) were diagnosed with MCMs within the first year of birth. Among the 7820 infants whose mothers were prescribed acetaminophen, 497 (6.4%) had MCMs. Of the 4772 infants were born to women prescribed KE, among whom 327 (6.9%) had MCMs. adjusting for covariates with propensity score overlap weights identified no significant difference in MCM risk between the two types of prescriptions (overlap‐weighted odds ratio 1.077, 95% confidence interval 0.932−1.245). Conclusion The results of this study indicated that the risk of MCMs did not differ between women prescribed KE and those prescribed acetaminophen in the first trimester of pregnancy.

  3. Medication use during pregnancy in Japan from 2005 to 2019: Trends and safety considerations

    Motohiko Adomi, Takamasa Sakai, Tomofumi Ishikawa, Taku Obara, Krista F. Huybrechts

    International Journal of Gynecology & Obstetrics　2026/03/07

    DOI： 10.1002/ijgo.70860 　

    ISSN： 0020-7292 1879-3479

    More details Close

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>Recent data on patterns and trends of medication use during pregnancy are limited in Japan. This study aimed to evaluate annual trends of medication use during pregnancy in Japan and identify frequently dispensed medications with limited safety evidence.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>A descriptive study was conducted using a pregnancy cohort nested within the JMDC claims database (2005–2019). Dispensing of medications before pregnancy and during each pregnancy trimester were evaluated. Annual trends were examined at the class and subclass medication level. Availability of evidence on teratogenic risk was assessed for the top 30 most commonly dispensed medications during the first trimester using the TERIS database.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 110 969 pregnancies (94 749 unique individuals) were included in the study. Acetaminophen was the most commonly dispensed medication across all windows. Other frequently dispensed medications included other analgesics, antiasthmatics, antibiotics, antiemetics, antiulcer medications, immunosuppressants, and thyroid medications. Annual trends revealed increased dispensing of analgesics (primarily acetaminophen), antiasthmatics (inhaled beta‐2 agonists, inhaled corticosteroids, leukotriene receptor antagonists), antiemetics (metoclopramide), and thyroid medications (thyroid hormone). Over 60% of the 30 most commonly dispensed medications during the first trimester lacked sufficient teratogenic safety evidence, particularly for antiasthmatics, antibiotics, and antivirals.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>A significant proportion of medications commonly dispensed during pregnancy in Japan have inadequate teratogenic safety evidence. Several medication classes showed increasing utilization trends over the study period, emphasizing the urgent need for targeted safety evaluations in the Japanese population.</jats:p> </jats:sec>

  4. Association of subjective and objective physical activity with home hypertension. International-journal

    Saki Hayashi, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Masato Takase, Sayuri Tokioka, Masatsugu Orui, Eiichi N Kodama, Yohei Hamanaka, Mami Ishikuro, Taku Obara, Satoshi Nagaie, Tomohiro Nakamura, Soichi Ogishima, Sho Nagayoshi, Mitsuo Kuwabara, Toshiyuki Iwaoka, Nobuo Fuse, Yoko Izumi, Naoki Nakaya, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　2026/02/24

    DOI： 10.1038/s41440-026-02587-8 　

    More details Close

    Prevention of hypertension (HT), a risk factor for cardiovascular diseases, and blood pressure (BP) control are important. For the prevention and management of high BP, increased physical activity (PA) is recommended as a lifestyle intervention. Although various PA assessment methods exist, their associations with clinical BP have been inconsistent. This study aimed to compare self-reported and accelerometer-measured PA in relation to home HT prevalence based on home BP, which has better reproducibility than office BP. We conducted this cross-sectional study of 5895 participants (mean age: 57.5 years, 70.4% women) in the Tohoku Medical Megabank Project Cohort Study. Total PA was assessed using two methods: self-reported activities (leisure, occupational/household) and accelerometer-measured values. Home HT was defined as morning home BP ≥ 135/85 mmHg or under HT treatment. Modified Poisson regression analysis showed no statistically significant association between self-reported total PA and the prevalence of home HT. In contrast, higher levels of accelerometer-measured total PA were associated with lower prevalence of home HT (P for trend <0.05). Regarding other accelerometer-measured components, higher light PA and more steps were also significantly associated with lower prevalence of home HT. These associations were largely mediated by body mass index. In conclusion, accelerometer-measured PA, unlike self-reported PA, was associated with home HT, suggesting that PA assessed by accelerometers is useful for understanding the relationship between PA and HT, preventing HT, and managing high BP.

  5. Genome-wide association study of social isolation in 63,497 Japanese individuals from the general population. International-journal

    Hisashi Ohseto, Kosuke Inoue, Ippei Takahashi, Taku Obara, Akira Narita, Mami Ishikuro, Masatsugu Orui, Keiko Murakami, Aoi Noda, Genki Shinoda, Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Yuka Kotozaki, Atsushi Shimizu, Kozo Tanno, Atsushi Hozawa, Gen Tamiya, Naoki Kondo, Shinichi Kuriyama

    Translational psychiatry　2026/02/17

    DOI： 10.1038/s41398-026-03896-9 　

    More details Close

    Social isolation, characterized by a lack of social connections with family, friends, and others, is associated with adverse health outcomes. However, the genetic contribution to the susceptibility to social isolation remains unclear. This study aimed to identify genetic loci associated with social isolation using the Lubben Social Network Scale (LSNS-6) in a Japanese population. The Tohoku Medical Megabank Community-Based Cohort Study was conducted between 2013 and 2016. The participants were genotyped using the Affymetrix Axiom Japonica Array. The LSNS-6 was used to assess familial and friend ties through six questions and social isolation statuses were defined using the total scale, family subscale, and friend subscale. Genome-wide association studies (GWASs) were conducted using a generalized linear mixed model, adjusting for age, sex, 10 genetic principal components and batch effects. In total, 63,497 participants who completed genotyping and the LSNS-6 were included. The mean age was 59.4 ± 11.9 years, and 41,126 (64.8%) were female. Significant genetic loci were identified in GWASs for the total scale (rs10736933 near ACADSB and HMX3) and friend subscale of LSNS-6 (rs1778366 near LINC02315 and LRFN5). This study provides the first genome-wide evidence of social isolation in the Japanese population, suggesting associations with ACADSB, HMX3, LINC02315, and LRFN5. These findings could enable personalized prevention and intervention for social isolation and related psychiatric disorders.

  6. Evaluation of the Safety of Taking Brexpiprazole During the Lactation Period. International-journal

    Akari Fukuda, Gen Oyanagi, Saya Kikuchi, Chihiro Iwasaki, Miyu Okubo, Aoi Noda, Kei Morishita, Nao Okabe, Riko Iwabuchi, Yuji Sato, Erika Kimura, Natsuko Kobayashi, Hasumi Tomita, Shinichi Sato, Noriyuki Iwama, Takushi Hanita, Masatoshi Saito, Hiroaki Tomita, Taku Obara, Nariyasu Mano

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine　15568253251408037-15568253251408037　2026/02/06

    DOI： 10.1177/15568253251408037 　

    More details Close

    INTRODUCTION: Brexpiprazole (BPZ), an antipsychotic drug introduced in 2018, is often used to manage psychiatric conditions. However, the effect of its use on infants whose mothers are receiving BPZ during lactation remains uncertain. Given the limited data on its effects on infants, this study evaluated the safety of its use by mothers during lactation. MATERIALS AND METHODS: Three mother-infant pairs were assessed between 2018 and 2023 at Tohoku University Hospital. Each mother continued BPZ monotherapy (1-2 mg/day) during pregnancy and lactation within the first month postpartum, and data on maternal and infant health, as well as withdrawal symptoms or adverse events in newborns and infants, were collected from medical records. RESULTS: No withdrawal symptoms or severe adverse events were noted in any of the three newborns or infants. Mild cases of neonatal jaundice and acne were observed in all three newborns and infants; however, they were considered unrelated to BPZ exposure. Nonetheless, it appears that the drug might have decreased milk supply, as supplemental formula feeding was occasionally necessary. CONCLUSION: This study suggests that BPZ monotherapy (1-2 mg/day) during lactation does not lead to withdrawal symptoms or serious adverse events in newborns or infants within the first month postpartum. This initial evidence may help inform breastfeeding decisions among mothers receiving BPZ monotherapy.

  7. Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression: Evidence from human cohort and mouse study

    Changrong Duan, Zhiqian Yu, Xue Li, Mai Sakai, Yuko Maejima, Kenju Shimomura, Tomoyuki Furuyashiki, Saya Kikuchi, Natsuko Kobayashi, Kazuto Sasaki, Tasuku Matsuki, Hiroshi Komatsu, Mizuki Hino, Yasuto Kunii, Tomoko Kasahara, Mami Ishikuro, Keiko Murakami, Masatsugu Orui, Takaaki Abe, Fuji Nagami, Nobuo Fuse, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Naoki Nakaya, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama, Hiroaki Tomita

    Molecular Psychiatry　2026/02/04

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41380-026-03456-z 　

    ISSN： 1359-4184

    eISSN： 1476-5578

    More details Close

    Abstract Maternal perinatal depression (MPD) is associated with reduced maternal plasma oxytocin (OXT) levels and an increased risk of autism spectrum disorder (ASD) in offspring. Using data from 23,218 Japanese mother–child pairs, we evaluated the relationship between MPD—assessed with the Kessler Psychological Distress Scale (K6) and the Edinburgh Postnatal Depression Scale (EPDS)—and autistic-related traits (ART) in toddlers, measured by the Tokyo Autistic Behavior Scale (TABS). We also tested the potential causal relationship of maternal stress exposure on OXT, its receptor (OXTR), and offspring outcomes using a prenatal stress-exposed mouse model. In the human cohort study, higher K6 or EPDS scores during pregnancy and postpartum were significantly associated with increased TABS scores in toddlers. Offspring of mothers with MPD (K6 or EPDS score ≥ 9) during pregnancy or postpartum exhibited a higher risk of ART (TABS score ≥ 15; P  &lt; 0.05). This risk was particularly pronounced in female toddlers exposed to MPD during pregnancy and postpartum (ORs: 5.805–9.367; P  &lt; 0.05). Female toddlers born to mothers with MPD also had lower birth weight, and their ART were positively correlated with K6 scores during mid-gestation and with impaired maternal bonding postpartum. In the mouse model, chronically stressed dams displayed depressive-like behaviors, and their female juveniles exhibited increased self-grooming and impaired social interaction. Furthermore, OXTR mRNA levels were significantly reduced in the prefrontal cortex of female juveniles from stressed dams. These findings suggest that MPD increases the risk of ART, particularly in females, highlighting potential sex-specific mechanisms underlying ASD susceptibility.

  8. Comparative analysis of the characteristics and trends of adverse drug reaction reports from patients in Japan and the Japanese Adverse Drug Event Report database. International-journal

    Masami Tsuchiya, Ryohkan Funakoshi, Koichi Masuyama, Nariyasu Mano, Satoko Hori, Taku Obara

    British journal of clinical pharmacology　92　(2)　515-524　2026/02

    DOI： 10.1002/bcp.70291 　

    More details Close

    AIMS: Spontaneous reporting of adverse drug reactions (ADR) after a product has reached the market is essential for drug safety. This study analysed patient ADR reports and compared them with reports from the Japanese Adverse Drug Event Report (JADER) database to identify differences and trends. METHODS: ADR reports from the Pharmaceuticals and Medical Devices Agency website, including patient reports from March 2019 to March 2024, and JADER reports from January 2019 to March 2024, were utilized. Information on demographics, drugs, ADR types and outcomes was analysed. Frequencies and comparisons between the two reporting groups were performed. RESULTS: A total of 2913 patient reports and 343 894 JADER reports were analysed. Patients were often younger (30-50 years) and mostly female, whereas JADER reports included older patients (60-80 years) and mostly male. Patients reported subjective symptoms, such as fatigue and headache, often associated with drugs targeting the central nervous system. In contrast, JADER reports focused on serious conditions, such as interstitial lung disease and pneumonia, which are commonly associated with anticancer drugs. Patient and professional ADR reports differed in focus. Patients highlighted quality-of-life-related symptoms, whereas professionals reported more serious medical conditions. Differences in demographics and reporting methods indicate that these systems are complementary. Offering more reporting options, such as telephone-based submissions, can make the system more inclusive. CONCLUSIONS: The study highlights how patient ADR reports provide valuable insights into drug safety. Although differences exist, patient and professional reports improve monitoring after drug approval.

  9. Distribution of axial length in Japanese children and adolescents aged 4 to 19 years.

    Shunsuke Fujioka, Naoko Takada, Sayaka Yoshida, Mami Ishikuro, Masayuki Kobayashi, Genki Shinoda, Aoi Noda, Masatsugu Orui, Taku Obara, Satoru Tsuda, Noriko Himori, Akiko Hanyuda, Ryo Kawasaki, Shinichi Kuriyama, Nobuo Fuse, Toru Nakazawa

    Japanese journal of ophthalmology　2026/01/19

    DOI： 10.1007/s10384-026-01328-1 　

    More details Close

    PURPOSE: To investigate the distribution of axial length (AL) and the prevalence of long axial length (LAL) in Japanese children and adolescents. STUDY DESIGN: cross-sectional observational study METHODS: We analyzed AL data from 14,482 participants (7,457 boys and 7,025 girls) aged 4-19 in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. AL was measured using a non-contact optical axis measurement device. We evaluated the distribution of AL in the participants with box plots for age. Segmented regression identified age-related trends and breakpoints. We calculated the age-specific proportions of participants with AL ≥ 24.5 mm and those with AL ≥ 26 mm, defined as LAL, which were considered indicative of suspected myopia. RESULTS: Mean AL increased with age, with a break point at 11.73 years. The slope before the break point was β = 0.27, while the slope after the break point decreased to β = 0.12. Boys showed earlier break point (9.87 years) than girls (15.91 years). Proportions with AL ≥ 24.5mm and ≥26mm began to increase approximately at 8 and 10 years of age respectively, with sex differences noted between ages 7 to 10 years and 10 to 11 years. CONCLUSION: This was the first large-scale AL survey in Japan and revealed the age and sex related distribution of AL and the proportion with LAL among Japanese children and adolescents aged 4 to 19 years.

  10. Twin pregnancies are risk factors for both early- and late-onset hypertensive disorders of pregnancy: the Japan Environment and Children's study. International-journal

    Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

    Hypertension research : official journal of the Japanese Society of Hypertension　2026/01/09

    DOI： 10.1038/s41440-025-02502-7 　

    More details Close

    This study investigated the associations of twin pregnancies with early-onset (EO)- and late-onset (LO)-hypertensive disorders of pregnancy (HDP). Totally, 86,717 pregnant women were included in a prospective birth cohort study. The associations of dichorionic diamniotic (DD)- and monochorionic diamniotic (MD)-twin pregnancies with EO-HDP (Diagnosed from 20 to <34 weeks of gestation) and LO-HDP (Diagnosed at ≥34 weeks of gestation) were analyzed using a multinomial logistic regression model. Compared with singleton pregnancies, both DD- and MD-twin pregnancies had significantly higher odds for EO- and LO-HDP. The adjusted odds ratios (aORs) for EO-HDP were 2.05 (95% confidence interval [Cl]: 1.51-2.78) in DD-twin pregnancies and 2.80 (95% Cl: 2.01-3.90) in MD-twin pregnancies, respectively. Also, the aORs for LO-HDP were 1.32 (95% CI: 1.03-1.69) in DD-twin pregnancies and 1.64 (95% Cl: 1.24-2.17) in MD-twin pregnancies, respectively. Although no statistically significant differences were observed, MD-twin pregnancies tended to have higher odds for both EO- and LO-onset HDP compared with DD-twin pregnancies. In conclusion, both DD- and MD-twin pregnancies are risk factors for the development of EO- and LO-HDP. We showed that both dichorionic diamniotic and monochorionic diamniotic twin pregnancies are risk factors for the development of early-onset and late-onset hypertensive disorders of pregnancy.

  11. Trajectories of paternal depression symptoms from 1 to 6 months postpartum and associated factors: An Adjunct Study of the Japan Environment and Children's Study. International-journal

    Taeko Suzuki, Toshie Nishigori, Taku Obara, Kasumi Sakurai, Mami Ishikuro, Hirotaka Hamada, Zen Watanabe, Masatoshi Saito, Chiharu Ota, Takahiro Arima, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi, Hidekazu Nishigori

    Infant mental health journal　47　(1)　e70047　2026/01

    DOI： 10.1002/imhj.70047 　

    More details Close

    This prospective birth-cohort study aimed to determine the factors associated with new-onset paternal depression symptoms from 1 to 6 months postpartum in Japan. Paternal depression symptoms were evaluated using the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS-J) at 1 to 6 months postpartum. The definition of paternal depression symptoms was EPDS-J ≥8 in this study. Multivariate regression analysis was performed to analyze the relative variables. We analyzed 902 fathers. The frequency of new-onset paternal depression symptoms was 6.5%. For paternal new-onset depression symptoms, the significantly associated factors were maternal persistent depression symptoms (adjusted odds ratio [AOR], 3.705; 95% confidence interval [CI], 1.653-8.308), paternal new-onset lack of affection (AOR, 2.797; 95% CI, 1.050-7.452), and paternal new-onset anger and rejection (AOR, 2.781; 95% CI, 1.148-6.740). Persistent maternal depression symptoms from 1 to 6 months postpartum were associated with new-onset paternal depression symptoms from 1 to 6 months postpartum.

  12. Age-related factors associated with preserved ratio impaired spirometry: The Tohoku medical Megabank project community-based cohort study. International-journal

    Chikashi Iwasaki, Kumi Nakaya, Mitsuhiro Yamada, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Masato Takase, Sayuri Tokioka, Taku Obara, Masatsugu Orui, Naoya Fujino, Akira Koarai, Tomoko Kobayashi, Yohei Hamanaka, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Nobuo Fuse, Shinichi Kuriyama, Hisatoshi Sugiura, Atsushi Hozawa

    Respiratory investigation　64　(1)　101343-101343　2026/01

    DOI： 10.1016/j.resinv.2025.101343 　

    More details Close

    BACKGROUND: Preserved ratio impaired spirometry (PRISm), defined as a forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio ≥0.70 and a predicted FEV1 <80 %, is associated with increased morbidity and mortality. However, determinants of PRISm, particularly in younger populations, remain poorly characterised. We aimed to address this knowledge gap. METHODS: We conducted a cross-sectional analysis of 12,350 participants from a Japanese community-based cohort using data from the Tohoku Medical Megabank Project. Participants underwent spirometry, blood pressure measurement, laboratory testing, and completed standardised questionnaires. Multivariate logistic regression was used to identify factors associated with PRISm across three age groups: 20-39, 40-59, and ≥60 years. Interactions between age groups and other explanatory variables were assessed. RESULTS: In the 20-39-year group, PRISm was independently associated with being men, diabetes mellitus, hypothyroidism, and low body mass index (BMI <18.5 kg/m2), and inversely associated with age. Among participants aged ≥60 years, PRISm was significantly associated with increasing age, overweight status (BMI ≥25.0-<30.0 kg/m2), being men, current smoking, hypertension, diabetes mellitus, bronchial asthma, elevated eosinophil counts (≥300 cells/μL), and birth weight ≥2000-<2500 g. Significant interactions were observed between age and BMI, bronchial asthma, and thyroid dysfunction. CONCLUSIONS: Our findings indicate that PRISm in younger adults is associated with hypothyroidism and underweight status, whereas in older adults, it is more closely related to constitutional and lifestyle-related factors. These results highlight the heterogeneity of PRISm and indicate that its pathophysiology and optimal management may vary by age group.

  13. Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization

    Rieko Hatanaka, Naoki Nakaya, Sayuri Tokioka, Ippei Chiba, Taku Obara, Hirohito Metoki, Masahiro Kikuya, Kotaro Nochioka, Masatsugu Orui, Kai Susukita, Masato Takase, Ikumi Kanno, Mana Kogure, Kumi Nakaya, Mami Ishikuro, Satoshi Nagaie, Soichi Ogishima, Yohei Hamanaka, Eiichi N. Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsuhi Hozawa

    Circulation Reports　2025/12/26

    Publisher: Japanese Circulation Society

    DOI： 10.1253/circrep.cr-25-0263 　

    eISSN： 2434-0790

  14. Temporal trends in the prescription of traditional Japanese herbal (Kampo) medicines to pregnant women: analysis of an administrative hospital database in Japan

    Daisuke Kikuchi, Taku Obara, Shiro Hatakeyama, Risa Josaka, Misaki Tokunaga, Kouji Okada, Yuriko Murai

    Journal of Pharmaceutical Health Care and Sciences　11　(1)　2025/12/24

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40780-025-00515-5 　

    eISSN： 2055-0294

    More details Close

    Abstract Background Japanese traditional (Kampo) medicines are commonly prescribed in clinical practice, with increasing evidence supporting their use during pregnancy. The efficacy and safety of Kampo medicines during pregnancy have increasingly been studied; however, evidence in support of these medicines is inadequate. Thus, we conducted a temporal trend analysis of Kampo medicine prescriptions to determine the Kampo medicines for which further safety evidence is required. Methods Administrative data from pregnant Japanese women who visited acute-care diagnosis procedure combination hospitals between January 1, 2014, and December 31, 2023, were used in this study. Therapeutic categories related to the Kyoto Encyclopedia of Genes and Genomes D numbers 5100 and 5200 were defined as target Kampo medicines. Annual prescription trends were calculated as proportions. Temporal trends in the proportion of prescriptions for each Kampo medicine were assessed using the Cochran–Armitage trend test. Statistical significance was set at p  &lt; 0.05. Results Between 2014 and 2023, the proportion of Kampo medicine prescriptions increased significantly from 12.0% to 13.6% ( p  &lt; 0.001). As of 2023, tokishakuyakusan (2.9%) was the most prescribed medication, followed by kakkonto (2.4%) and daikenchuto (2.0%). From 2014 to 2023, the proportions of tokishakuyakusan (3.3% to 2.9%) and kakkonto (2.4% to 2.4%) prescriptions showed no significant temporal changes ( p  = 0.07 and 0.36, respectively). In contrast, the proportion of daikenchuto prescriptions increased significantly from 0.8% to 2.0% ( p  &lt; 0.001). Conclusion The primary prescribed Kampo medicines were those with established safety evidence for use in pregnant women. The proportion of Kampo medicine prescriptions for pregnant women in Japan has increased over time, with tokishakuyakusan being the most prescribed during the study period.

  15. Small for gestational age by grandmaternal smoking during pregnancy: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Mustakim, Mami Ishikuro, Chikana Kawaguchi, Genki Shinoda, Aoi Noda, Masatsugu Orui, Keiko Murakami, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

    Journal of developmental origins of health and disease　16　e46　2025/12/15

    DOI： 10.1017/S2040174425100305 　

    More details Close

    Small-for-gestational age (SGA) is an important global public health issue because of its increasing prevalence and long-term effects. Maternal smoking is a known risk factor for SGA; however, the effect of grandmaternal smoking on the risk of SGA in grandchildren SGA remains unclear. In this study, we examined whether grandmaternal smoking during pregnancy was associated with small birth weight, length, and head circumference for gestational age. Data were obtained from 23,730 pregnant women and their offspring from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Studies. A total of 1,130 grandmaternal-maternal-child triads were identified. Grandmaternal smoking during pregnancy was defined by the Maternal and Child Health Handbook owned by the mothers at birth mothers when they were born. Birth outcomes of grandchildren were obtained from medical records and converted to SGA using the 10th percentile for weight, length, and head circumference. A multivariate logistic regression and propensity scores were used for the analysis. Prevalence of <10th percentile for birth weight, length, and head circumference in grandmaternal smokers were 10.2%, 2.0%, and 10.2%, respectively. Grandmaternal smoking during pregnancy was associated with the lower grandchild's birth weight (odds ratio (OR) [95% (CI)]: 2.86 [1.05-7.82]) and remained consistent when adjusted by propensity score (OR [95% CI]: 2.87 [1.04-7.92]). Grandmaternal smoking should not be ignored when assessing the SGA risk. Future work should consider the complex mediating relationship between smoking and growth restriction across generations.

  16. Risk of Major Congenital Malformations Associated With First‐Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study

    Tadaharu Kunitoki, Takamasa Sakai, Tomofumi Ishikawa, Ryo Obara, Kei Morishita, Azusa Hara, Motohiko Adomi, Haruto Watanabe, Kaya Hayasaka, Yuna Yoshida, Aki Shimizu, Genki Shinoda, Aoi Noda, Mami Ishikuro, Masatsugu Orui, Noriyuki Iwama, Seiko Yamakoshi, Emiko Sato, Nariyasu Mano, Shinichi Kuriyama, Nobuyuki Takahashi, Taku Obara

    Pharmacoepidemiology and Drug Safety　34　(12)　2025/12/05

    Publisher: Wiley

    DOI： 10.1002/pds.70274 　

    ISSN： 1053-8569

    eISSN： 1099-1557

    More details Close

    ABSTRACT Purpose Vulvovaginal candidiasis is highly prevalent among pregnant women, and its treatment is crucial. However, there is a lack of evidence regarding the risks on fetal outcomes associated with the use of antifungal medications during the first trimester of pregnancy in Japan. This study examined the association between topical antifungal use during the first trimester of pregnancy and the risk of major congenital malformations (MCMs) in infants using a Japanese database. Methods We conducted a cohort study using a pregnancy cohort nested in the JMDC Claims Database from Japan. This dataset included 12 472 women who gave birth between 2010 and 2019 and were diagnosed with vulvovaginal candidiasis. Among the antifungal medications frequently dispensed or prescribed during the first trimester of pregnancy in this cohort, miconazole, oxiconazole, and isoconazole were assessed for the risk of MCMs, using clotrimazole, an antifungal medication with established safety during pregnancy, as a reference. Results Among 12 472 women, the overall prevalence of MCMs was 5.8% ( n  = 249) in women exposed to topical antifungals, while unexposed were 6.2% ( n  = 508). Using propensity score overlap weight (wOR), no increased risk of MCMs in infants was observed in pregnancies exposed to oxiconazole, isoconazole, and miconazole compared to clotrimazole (overlap weighted odds ratio [95% confidence interval]: 0.875 [0.599–1.277], 1.001 [0.611–1.640], and 0.887 [0.497–1.581], respectively). Conclusion There was no significant association between topical antifungal use during the first trimester of pregnancy and the risk of MCMs in infants in Japan.

  17. Relationship between age-related hearing loss and alcohol consumption in a Japanese population. International-journal

    Hiyori Takahashi, Jun Suzuki, Ikuko N Motoike, Miyuki Sakurai, Yuta Kobayashi, Gosuke Watarai, Hiroki Tozuka, Mana Kogure, Tetsuaki Kawase, Yohei Honkura, Ryoukichi Ikeda, Kengo Kinoshita, Naoki Nakaya, Taku Obara, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto, Yukio Katori

    Scientific reports　16　(1)　336-336　2025/12/02

    DOI： 10.1038/s41598-025-29634-7 　

    More details Close

    Age-related hearing loss (ARHL) has a multifactorial pathogenesis, and the influence of alcohol consumption on it is controversial. This cross-sectional study investigated the association between ARHL and alcohol consumption by using cohort data from Tohoku Medical Megabank Project, including self-reported questionnaires and pure-tone audiometry thresholds (500, 1000, 2000, and 4000 Hz). ARHL was defined as a threshold of > 25 dB in the better ear. Multiple logistic regression analyses (age 50-79 y; 5,219 men and 9,266 women) were conducted separately for men and women and indicated that daily alcohol consumption levels of 60-80 and ≥ 80 g were significantly associated with increased odds of ARHL at 4,000 Hz in men (odds ratio [OR] 1.42; 95% confidence interval [CI] 1.05-1.94; OR 1.55; 95% CI 1.12-2.16; respectively); consumption of 10-20 g was significantly associated with reduced odds of ARHL at 4,000 Hz in women (OR 0.81; 95% CI 0.68-0.96). Assessment of drinking-related single nucleotide polymorphisms suggested that the effect of alcohol on ARHL may differ by genotype. Our findings suggest a sex-specific association between alcohol consumption and ARHL; heavy drinking is a potential risk factor in men, whereas moderate drinking may have a protective effect in women.

  18. The relationship between preeclampsia subtypes and birth weight to placental weight ratio: Insights from a study of 17,709 pregnant Japanese women. International-journal

    Hisashi Ohseto, Mami Ishikuro, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama

    Placenta　172　100-103　2025/12

    DOI： 10.1016/j.placenta.2025.10.017 　

    More details Close

    The placenta plays a crucial role in preeclampsia (PE) pathogenesis, with early onset (EOPE) and late onset (LOPE) presenting with unique manifestations. In this prospective study of 17,709 pregnant Japanese women, the relationship between the PE subtype and birth weight to placental weight ratio (BW/PW ratio) was examined. EOPE was not associated with BW/PW ratio, which was consistent with reduced birth and placental weights. LOPE showed lower BW/PW ratios, indicating potential adaptive hypertrophy of the placenta. These results emphasize the consideration of PE subtypes when utilizing the BW/PW ratio as an index of placental function and to elucidate PE mechanisms.

  19. Screening for Psychological Distress, Disaster-Related Experiences, and Newly Developed Mental Disorders among Residents Affected by the Great East Japan Earthquake: Implications for Suicide Prevention

    Masatsugu Orui, Mana Kogure, Yuka Kotozaki, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Hirohito Metoki, Masahiro Kikuya, Yoshitake Takebayashi, Masaharu Maeda, Naoki Nakaya, Kozo Tanno, Atsushi Hozawa, Shinichi Kuriyama

    JMA JOURNAL　2025/11/28

    DOI： 10.31662/jmaj.2025-0257 　

    ISSN： 2433-328X

    eISSN： 2433-3298

  20. Association of Mediterranean Diet Scores with Psychological Distress in Pregnancy: The Japan Environment and Children's Study. International-journal

    Yuri Takahashi, Zen Watanabe, Noriyuki Iwama, Natsumi Kumagai, Hirotaka Hamada, Hikaru Karumai-Mori, Seiya Izumi, Emi Yokoyama, Yasuno Takahashi, Takeki Sato, Jumpei Toratani, Kazuma Tagami, Hasumi Tomita, Masahito Tachibana, Mami Ishikuro, Taku Obara, Hirohito Metoki, Tomohisa Suzuki, Yuichiro Miura, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito, The Japan Environment And Children's Study Group

    Nutrients　17　(23)　2025/11/25

    DOI： 10.3390/nu17233697 　

    More details Close

    Background/Objectives: Perinatal mental disorders are important health issues that affect both mothers and their children. The Mediterranean diet (MD) is one of the most well-recognized healthy dietary patterns worldwide. Recent evidence suggests that MD may prevent or reduce the risk of perinatal mental disorders. This study investigated the association between MD adherence during pregnancy and psychological distress in a large cohort of Japanese births. Methods: Data were obtained from 80,271 pregnant women who participated in the Japan Environment and Children's Study. Adherence to the MD was assessed using three scoring methods: the Mediterranean Diet Score (MDS), relative Mediterranean Diet (rMED), and Mediterranean Diet Score for Pregnancy (PMDS). Psychological distress was defined as a score of ≥13 on the Kessler 6-item Psychological Distress Scale (K6). Modified Poisson regression models were used to estimate risk ratios (RRs) and 95% confidence intervals (CIs). Population attributable fractions (PAFs) were calculated to quantify the proportion of psychological distress attributable to low MD adherence. Results: The adjusted RR for psychological distress in the low PMDS group was 1.17 (95% CI: 1.07, 1.28) compared with the high PMDS group. The adjusted PAF for low PMDS was 10.43% (95% CI: 4.81, 16.06). No statistically significant associations were detected between psychological distress and the MDS or rMED scores. Conclusions: This study suggests that high adherence to MD based on the PMDS during pregnancy may reduce the risk of psychological distress in Japanese women. Therefore, promoting MD during pregnancy could be a potential strategy for preventing perinatal mental disorders.

  21. Comparison of the associations between office and home BP with placenta-mediated pregnancy complications: the BOSHI study. International-journal

    Noriyuki Iwama, Seiya Izumi, Hiroki Nobayashi, Takahisa Murakami, Michihiro Satoh, Hasumi Tomita, Hirotaka Hamada, Mami Ishikuro, Taku Obara, Masatoshi Saito, Takayoshi Ohkubo, Shinichi Kuriyama, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　2025/11/20

    DOI： 10.1038/s41440-025-02439-x 　

    More details Close

    This prospective cohort study compared the associations between office blood pressure (OBP) and home blood pressure (HBP) measured before 20 weeks of gestation with the subsequent development of placenta-mediated pregnancy complications (PMPCs). A total of 975 pregnant women were included in the study. OBP and HBP were measured between 10 weeks 0 days and 19 weeks 6 days of gestation, using HBP values from the same gestational weeks as OBP. When both OBP and HBP were included simultaneously in a binary logistic regression model, per 1 standard deviation increase, the adjusted odds ratios (aORs) for office and home systolic blood pressure (SBP) were 1.16 (95% confidence interval [CI]: 0.95-1.42) and 1.68 (95% CI: 1.36-2.09), respectively. For diastolic blood pressure (DBP), the aORs were 1.36 (95% CI: 1.10-1.69) for office and 1.70 (95% CI: 1.37-2.12) for home measurements. The likelihood ratio test showed that adding home SBP to a model with office SBP improved model fit (P value < 0.0001), whereas adding office SBP to a model with home SBP did not (P value = 0.2). For DBP, adding either home or office values improved model fit (P value < 0.0001 and P value = 0.005, respectively). Home SBP was more strongly associated with PMPCs than office SBP. Although home DBP was not statistically stronger than office DBP, its effect estimate was higher. These findings support the added value of HBP monitoring during pregnancy for predicting PMPCs.

  22. Suitability of Japanese Medical Databases for Studies on Infant Outcomes After Maternal Drug Exposure: An Evaluation Based on Core Data Elements

    Shiro Hatakeyama, Takamasa Sakai, Masami Tsuchiya, Daisuke Kikuchi, Yuri Sato, Yuki Kondo, Izumi Sato, Yuko Okada, Taku Obara

    Pharmacoepidemiology and Drug Safety　34　(11)　2025/11/12

    Publisher: Wiley

    DOI： 10.1002/pds.70264 　

    ISSN： 1053-8569

    eISSN： 1099-1557

    More details Close

    ABSTRACT Purpose Pharmacotherapy during pregnancy should be approached with caution due to the potential risk of adverse effects, including birth defects, in the fetus. Appropriate post‐marketing surveillance and perinatal pharmacoepidemiology are essential to ensure the safety of pharmacotherapy during pregnancy. However, due to limited research infrastructure in pharmacoepidemiology, collecting reliable data on drug safety in pregnant women and infants remains a challenge in Japan. Thus, we examined the suitability (fitness for purpose) of Japanese medical databases for perinatal studies to establish infrastructure in this field. Methods We assessed seven available databases in Japan: the DeSC database, EBM provider, Japanese Adverse Drug Event Report database, JMDC claims database, MDV analyzer, the National Database of Health Insurance Claims, and Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study (TMM BirThree Cohort Study). To assess the quality of databases for maternal studies, we evaluated the content of each mother‐infant linkable database based on the core data elements recommended for perinatal pharmacoepidemiology. Results Three of the databases were found to be mother‐infant linkable: the DeSC database, JMDC claims database, and the TMM BirThree Cohort Study. The coverage of core data elements in perinatal pharmacoepidemiology was 73.5% in the DeSC and JMDC claims databases and 92.9% in the TMM BirThree Cohort Study. Conclusion Some representative medical databases in Japan are well suited for use in perinatal pharmacoepidemiologic research on infant outcomes.

  23. Population attributable fraction of all-cause mortality due to non-normal blood pressure: results from the 2013 to 2016 baseline survey of the TMM CommCohort Study

    Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Masato Takase, Yuka Kotozaki, Taku Obara, Satoshi Nagaie, Hideki Ohmomo, Takahito Nasu, Michihiro Satoh, Takahisa Murakami, Hirohito Metoki, Yohei Hamanaka, Masatsugu Orui, Eiichi N. Kodama, Nobuo Fuse, Yoko Izumi, Kozo Tanno, Atsushi Hozawa

    Hypertension Research　2025/11/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-025-02436-0 　

    ISSN： 0916-9636

    eISSN： 1348-4214

    More details Close

    Abstract Antihypertensive therapy has reduced cardiovascular mortality; however, challenges remain, including residual risk in treated patients and the population burden associated with borderline hypertension. Previous Japanese estimates of the population attributable fraction (PAF) are derived from older cohorts and often lacked stratification by treatment status. We conducted a prospective study of 61,495 participants (women: 56.7%, aged 60.7 ± 11.0 years) from the Tohoku Medical Megabank Community-Based Cohort Study. Participants were classified into six blood pressure (BP) categories based on the JSH 2019 guidelines, and further stratified by hypertension treatment status, resulting in 12 groups. Using untreated individuals with normal BP as the reference, we calculated multivariable-adjusted hazard ratios (HR), 95% confidence intervals (CI), and PAF for the remaining groups using Cox proportional hazards model. During a median follow-up of 6.5 years, 1909 deaths were recorded. HRs increased with rising BP in both untreated and treated participants. The overall PAF for all-cause mortality due to non-normal BP was 9.45%, with a marked sex difference (12.25% in male and 5.16% in female). The highest PAF contributions were observed in the treated Grade I hypertension group (2.18%) and the untreated elevated BP group (1.28%). In this contemporary Japanese cohort, non-normal BP accounts for 9.45% of all-cause mortality, representing a substantial public health burden, particularly among men. The substantial PAF contributions from both treated patients and untreated individuals with elevated BP highlight the importance of effective BP management for both primary and secondary prevention.

  24. Child Developmental Patterns by Age 4 Years Across Subtypes of Hypertensive Disorders of Pregnancy. International-journal

    Geng Chen, Mami Ishikuro, Hisashi Ohseto, Aoi Noda, Genki Shinoda, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

    JAMA network open　8　(11)　e2545719　2025/11/03

    DOI： 10.1001/jamanetworkopen.2025.45719 　

    More details Close

    IMPORTANCE: Exposure to hypertensive disorders of pregnancy (HDP) during the fetal stage has been linked to developmental delays in children. However, the associations between HDP subtypes and longitudinal patterns in child development remain unclear. OBJECTIVE: To investigate the associations of HDP subtypes with child developmental patterns. DESIGN, SETTING, AND PARTICIPANTS: This study used data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study recruiting pregnant individuals in Japan between July 2013 and March 2017. Mother-child pairs were included in the analysis. The data analysis was conducted from November 2023 to February 2024. EXPOSURES: HDP and its subtypes (gestational hypertension and preeclampsia) were identified using an algorithm applied to antenatal visit records. MAIN OUTCOMES AND MEASURES: The latent class trajectory model was applied to child development scores at ages 6, 12, 24, 42, and 48 months to generate patterns in 5 domains (communication, gross motor, fine motor, problem solving, and personal-social). Multinomial Poisson regression analysis calculated the risk ratios (RRs) of different developmental patterns by exposure to any HDP as well as HDP subtypes. A subgroup analysis was performed by preterm birth. RESULTS: Among 14 023 mother-child pairs (maternal mean [SD] age, 32.5 [4.8] years; 6754 [48.2%] female children), 1406 (10.0%) were exposed to HDP. Three patterns were identified in the 5 domains: normal, delay, and catch-up. Point estimates for delays in multiple domains of development were greater for any HDP, preeclampsia, and early-onset preeclampsia, but not all findings were statistically significant. Early-onset preeclampsia was associated with a significantly higher risk of delay pattern in problem solving domain (RR, 2.90; 95% CI, 1.43-5.89; adjusted P = .047), although the risks of delay pattern were not statistically significant in communication (RR, 1.94; 95% CI, 1.14-3.29; adjusted P = .15), gross motor (RR, 2.10; 95% CI, 1.26-3.51; adjusted P = .06), or fine motor (RR, 2.68; 95% CI, 1.26-5.71; adjusted P = .11) domains. In the term-born population, children exposed to preeclampsia and had an RR greater than 1 for the delay pattern in the problem solving domain (RR, 1.67; 95% CI, 1.92-2.74; adjusted P = .60), although this finding was not statistically significant after adjusting for multiple comparisons. CONCLUSIONS AND RELEVANCE: In this cohort study, fetal exposure to early-onset preeclampsia was associated with higher risk of a delayed child developmental pattern in the problem solving domain. The observations were modified by preterm birth. These findings suggest that children exposed to certain HDP subtypes during fetal life require developmental monitoring, especially if they were born preterm.

  25. Maternal sleep disorders during pregnancy and subsequent risk of allergic diseases in Japanese children: the TMM BirThree Cohort Study. International-journal

    Ami Uematsu, Masatsugu Orui, Mami Ishikuro, Keiko Murakami, Aoi Noda, Genki Shinoda, Taku Obara, Shinichi Kuriyama

    Clinical and experimental pediatrics　2025/10/22

    DOI： 10.3345/cep.2025.01165 　

    More details Close

    BACKGROUND: Associations have been suggested between prenatal exposure and allergic diseases in children as well as between respiratory allergies and maternal sleep disorders during pregnancy. PURPOSE: This study aimed to examine the association between maternal sleep disorders during pregnancy and allergic diseases, including respiratory, skin, and ocular allergies, in their children. METHODS: This study was based on the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Sleep disorders during pregnancy were defined as an Athens Insomnia Scale score of ≥6. Allergic diseases in children up to 5 years of age were assessed by maternal selfreport on "bronchial asthma," "atopic dermatitis," "food allergy," and "allergic conjunctivitis/allergic rhinitis/hay fever." Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a Cox proportional hazards model. RESULTS: A total of 11,123 mother-child pairs were included. The mean gestational age at registration was 19.6±7.6 weeks. During pregnancy, 4,115 women (37.0%) experienced sleep disorders. Additionally, 53.7% of the participants had a history of parity, 8.8% worked night shifts, and 0.4% used sleep medications. In the crude models, maternal sleep disorders during pregnancy were associated with all examined allergic diseases in children. After the adjustment for all confounders, the associations remained significant for atopic dermatitis and allergic conjunctivitis/ allergic rhinitis/hay fever (HR [95% CI], 1.09 [0.97-1.23] for bronchial asthma, 1.17 [1.05-1.31] for atopic dermatitis, 1.11 [0.98-1.26] for food allergy, and 1.25 [1.13-1.39] for allergic conjunctivitis/allergic rhinitis/hay fever). CONCLUSION: Maternal sleep disorders during pregnancy were associated with atopic dermatitis as well as allergic conjunctivitis/allergic rhinitis/hay fever in children.

  26. Impact of cumulative blood pressure load during early pregnancy on the risk of low birth weight: the BOSHI study

    Hiroki Nobayashi, Seiya Izumi, Michihiro Satoh, Noriyuki Iwama, Takahisa Murakami, Go Kanzaki, Yutaro Iwabe, Yuya Suzuki, Mami Ishikuro, Nobuo Tsuboi, Taku Obara, Takayoshi Ohkubo, Yutaka Imai, Takashi Yokoo, Hirohito Metoki

    HYPERTENSION RESEARCH　2025/10/20

    DOI： 10.1038/s41440-025-02421-7 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  27. Impact of cumulative blood pressure load during early pregnancy on the risk of low birth weight: the BOSHI study. International-journal

    Hiroki Nobayashi, Seiya Izumi, Michihiro Satoh, Noriyuki Iwama, Takahisa Murakami, Go Kanzaki, Yutaro Iwabe, Yuya Suzuki, Mami Ishikuro, Nobuo Tsuboi, Taku Obara, Takayoshi Ohkubo, Yutaka Imai, Takashi Yokoo, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　2025/10/20

    DOI： 10.1038/s41440-025-02421-7 　

    More details Close

    This study investigated the association between cumulative blood pressure (BP) load, defined as the area above a threshold reflecting the duration and magnitude of BP elevation, and low birth weight (LBW). We included 729 pregnant women in this prospective cohort study. Home BP measurements collected at 10 weeks 0 days and 15 weeks 6 days were assessed. The participants were classified into three groups based on their cumulative BP load: (1) no cumulative BP load elevation, (2) isolated cumulative BP load elevation (with normal average BP), and (3) high average BP (average BP above the normal range). Normal ranges (systolic BP < 115 mmHg, diastolic BP < 75 mmHg) were defined following the guidelines; BP load threshold (systolic BP < 104 mmHg, diastolic BP < 62 mmHg) was set using median averages. The mean age at pregnancy was 31.2 years, and 54.4% were primiparas. The mean birth weight was 3060 g; 47 newborns had LBW. The groups with isolated cumulative systolic BP load elevation (risk ratio [RR]: 2.86, 95% confidence interval [CI]: 1.33-6.17) and high average systolic BP (RR: 3.57, 95% CI: 1.38-9.24) showed higher LBW risk than the group without cumulative systolic BP load elevation. Similar associations were observed for cumulative diastolic BP load elevation (RR: 2.22, 95% CI: 1.08-4.58) and high average diastolic BP (RR: 3.35, 95% CI: 1.08-10.34). Our findings highlight the significance of monitoring home BP and the utility of the cumulative BP load in evaluating LBW risk. This study evaluated the association between cumulative blood pressure (BP) load elevation during early pregnancy and the risk of low birth weight (LBW). Elevation of both cumulative systolic and diastolic BP load was associated with an increased risk of LBW, even when average BP remained within the normal range.

  28. Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk. International-journal

    Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Ikumi Kanno, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Clinical kidney journal　18　(10)　sfaf275　2025/10

    DOI： 10.1093/ckj/sfaf275 　

    ISSN： 2048-8505

    eISSN： 2048-8513

  29. Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study. International-journal

    Genki Shinoda, Taku Obara, Ippei Takahashi, Hisashi Ohseto, Chikana Kawaguchi, Akira Narita, Aoi Noda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Makiko Taira, Hiroshi Sakamoto, Naoki Nakaya, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Shunji Mugikura, Kyoko Suzuki, Shinichi Kuriyama

    Genes, brain, and behavior　24　(5)　e70038　2025/10

    DOI： 10.1111/gbb.70038 　

    More details Close

    Heritability of cognitive function is estimated to be 50%-80%. Genome-wide association studies (GWASs) have identified multiple cognitive function-associated loci, primarily in the European population. However, those in Asian populations, particularly in individuals of Japanese ancestry, remain limited. Hence, this GWAS aimed to identify cognitive function-associated genetic loci in elderly individuals of Japanese ancestry. Herein, 2571 elderly participants from the Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study were included. Their cognitive function was assessed using the Japanese version of the Mini-Mental State Examination (MMSE), and both binary and continuous MMSE scores were analysed. Genotyping was performed using the Affymetrix Axiom Japonica Array v2, and imputation was conducted with 3.5KJPNv2 and 1KGP3. Statistical analyses were performed using FastGWA-GLMM and FastGWA for binary and continuous MMSE scores, respectively. Although no genome-wide significant loci were identified using binary MMSE values, the following two were detected using continuous MMSE values: rs77877360 (20p12.1) near BANF2 and SNX5 and rs9460729 (6p22.3) near PRL and HDGFL1. Additionally, functional annotation suggested the involvement of these loci in pathways related to cognitive function, including chromatin structure regulation, neuroinflammation, and iron metabolism. Notably, SNX5, identified through chromatin-interaction mapping, has been implicated in neurodegenerative processes, particularly in Parkinson's disease. The findings of this study provide preliminary genome-wide evidence suggesting a genetic predisposition to impaired cognitive function in elderly Japanese individuals.

  30. Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension. International-journal

    Masato Takase, Takumi Hirata, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Hirohito Metoki, Michihiro Satoh, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Hypertension research : official journal of the Japanese Society of Hypertension　48　(10)　2606-2617　2025/10

    DOI： 10.1038/s41440-025-02314-9 　

    More details Close

    Family history of hypertension may reflect genetic and lifestyle factors. Genetic risk can be assessed using polygenic risk score (PRS); however, whether PRS can stratify hypertension risk when combined with family history and lifestyle information is unclear. This prospective cohort study included 9,001 hypertension-free individuals aged ≥20 years from the Tohoku Medical Megabank Community-Based Cohort Study. Participants were scored on lifestyle factors, including body mass index, urinary sodium-to-potassium ratio, physical activity, alcohol consumption, and smoking at recruitment. During the mean follow-up of 4.3 years, 2822 (31.4%) cases of hypertension occurred. High genetic risk and poor lifestyle were associated with increased hypertension risk. Compared with participants with low genetic risk, ideal lifestyle, and no family history, high genetic risk significantly increased hypertension risk, even among those with ideal lifestyle and no family history (relative risk [RR] 1.28 [95% confidence interval [CI] 1.11-1.46]). Participants with low PRS, ideal lifestyle, but with family history had increased hypertension risk (RR 1.32 [95%CI 1.11-1.57]). Poor lifestyle increased hypertension risk across most genetic risk groups, regardless of family history. Integrating PRS into models with family history and lifestyle risk significantly improved predictive accuracy (area under the curve: 0.671 for family history and lifestyle risk and 0.674 for PRS integrated; P for difference <0.05). Integrating PRS with lifestyle and family history enhances the stratification of individuals at high risk for hypertension.

  31. Electrocardiogram characteristics and possible associated factors in healthy Japanese children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Shingo Nakashima, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Taku Obara, Shinichi Kuriyama

    BMC pediatrics　25　(1)　697-697　2025/09/29

    DOI： 10.1186/s12887-025-06025-5 　

    More details Close

    BACKGROUND: The number of young patients with cardiac disease has recently increased. To describe the electrocardiogram characteristics and identify the possible factors affecting the characteristics in early life might be helpful for the prevention and assessment of abnormal cardiac function. The aim of this study is to analyze the electrocardiogram characteristics of healthy children and investigate the possible associated factors in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. METHODS: Children were recruited between 2013 and 2017 and the ECG parameters for 6,061 children. Student's t-test was conducted to confirm sex-related differences. ECG parameters were also described by age. Multiple regression analysis of 2,285 children, whose body mass index and their parents' ECG parameters were available in addition to sex and age, was used to analyze the possible factors associated with ECG characteristics. In addition, ECG parameters were compared between gestational age < 37 (premature birth) and ≥ 37. RESULTS: Heart rate, QRS duration, QT interval, corrected QT interval, and P-QRS-T axes showed significant sex-related differences (P < 0.05), and the QRS duration varied with age. The ECGs of parents in PR interval and QRS duration were associated with those of children (Boys: β [95% confidence interval] was 0.17[0.12-0.22] and 0.18[0.14-0.23] with mothers, 0.11[0.063-0.16] and 0.11[0.075-0.15] with fathers, Girls: 0.12[0.074-0.16] and 0.16[0.12-0.20] with mothers, 0.090[0.050-0.13] and 0.089[0.056-0.12] with fathers). Maternal QTc and P axes were also associated with child QTc and P axes. Premature birth showed significantly difference only in the QRS axis (P = 0.02). CONCLUSION: This study described the ECG characteristics of Japanese children and found a relation between parents and children. ECG parameters in children aged 4-9 correlate with those in their parents, but not with sex or BMI. In particular, mother's ECG was strongly associated with that of children than father's ECG. The relation might be reflected by both genetic background and uterine environment.

  32. Changes in the trend and quality of adverse drug reaction reports in the Japanese Adverse Drug Event Report database and the impact of COVID-19-related reports. International-journal

    Masami Tsuchiya, Takamasa Sakai, Naoto Okada, Ryohkan Funakoshi, Koichi Masuyama, Nariyasu Mano, Satoko Hori, Taku Obara

    The International journal of pharmacy practice　2025/09/27

    DOI： 10.1093/ijpp/riaf084 　

    More details Close

    OBJECTIVES: This study aimed to identify the impact of the coronavirus disease 2019 (COVID-19) pandemic on changes in the trend and quality of adverse drug reaction (ADR) reports in the Japanese Adverse Drug Events Report (JADER) database using the vigiGrade completeness score as an indicator. METHODS: A JADER dataset consisting of ADR reports from April 2004 to March 2025 was used. VigiGrade completeness scores were determined for ADR reports, and the quality of the reports was assessed as 'well documented' or not, depending on the score obtained. KEY FINDINGS: Of 969 520 ADR reports, 393 168 submitted between the fourth quarter of 2018 and the fourth quarter of 2024 were included. The number of ADR reports declined in the first quarter of 2020 but peaked in the second quarter of 2021. The proportion of 'well-documented' reports remained between ~20% and 30% during most quarters, but increased to ~40% in the first and second quarters of 2021, during which COVID-19 vaccine-related reports accounted for 29.0% and 39.2% of all reports, respectively. This surge in vaccine-related submissions coincided with a temporary improvement in documentation quality. CONCLUSIONS: The COVID-19 pandemic and the increase in ADR reports related to COVID-19 vaccines have affected the trends and quality of reporting in the JADER database. Notably, a substantial increase in vaccine-related ADRs during mass immunization corresponded with a temporary rise in reporting quality. These findings highlight the importance of maintaining robust pharmacovigilance systems that can adapt to large-scale public health interventions and sustain data quality during future emergencies.

  33. Comparative analysis of the characteristics and trends of adverse drug reaction reports from patients in Japan and the Japanese Adverse Drug Event Report database

    Masami Tsuchiya, Ryohkan Funakoshi, Koichi Masuyama, Nariyasu Mano, Satoko Hori, Taku Obara

    British Journal of Clinical Pharmacology　2025/09/20

    Publisher: Wiley

    DOI： 10.1002/bcp.70291 　

    ISSN： 0306-5251

    eISSN： 1365-2125

    More details Close

    Aims Spontaneous reporting of adverse drug reactions (ADR) after a product has reached the market is essential for drug safety. This study analysed patient ADR reports and compared them with reports from the Japanese Adverse Drug Event Report (JADER) database to identify differences and trends. Methods ADR reports from the Pharmaceuticals and Medical Devices Agency website, including patient reports from March 2019 to March 2024, and JADER reports from January 2019 to March 2024, were utilized. Information on demographics, drugs, ADR types and outcomes was analysed. Frequencies and comparisons between the two reporting groups were performed. Results A total of 2913 patient reports and 343 894 JADER reports were analysed. Patients were often younger (30–50 years) and mostly female, whereas JADER reports included older patients (60–80 years) and mostly male. Patients reported subjective symptoms, such as fatigue and headache, often associated with drugs targeting the central nervous system. In contrast, JADER reports focused on serious conditions, such as interstitial lung disease and pneumonia, which are commonly associated with anticancer drugs. Patient and professional ADR reports differed in focus. Patients highlighted quality‐of‐life‐related symptoms, whereas professionals reported more serious medical conditions. Differences in demographics and reporting methods indicate that these systems are complementary. Offering more reporting options, such as telephone‐based submissions, can make the system more inclusive. Conclusions The study highlights how patient ADR reports provide valuable insights into drug safety. Although differences exist, patient and professional reports improve monitoring after drug approval.

  34. Exploring risk factors for axial length elongation: a population-based cohort study of 9195 eyes in Japan

    Takayuki Nishimura, Hiroshi Kunikata, Naoko Takada, Makoto Ishikawa, Sayuri Tokioka, Rieko Hatanaka, Mana Kogure, Ippei Chiba, Kumi Nakaya, Taku Obara, Yoko Izumi, Akira Uruno, Satoshi Nagaie, Soichi Ogishima, Naoki Nakaya, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Fuse, Toru Nakazawa

    BRITISH JOURNAL OF OPHTHALMOLOGY　2025/09/15

    DOI： 10.1136/bjo-2025-327213 　

    ISSN： 0007-1161

    eISSN： 1468-2079

  35. Validity of a self-administered food frequency questionnaire for assessing carotenoid intakes using serum biomarkers in Japan: the Tohoku Medical Megabank Project.

    Keiko Murakami, Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Ribeka Takachi, Shiori Sugawara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisaaki Kudo, Kazuki Kumada, Masayuki Yamamoto, Shinichi Kuriyama

    Journal of epidemiology　2025/09/06

    DOI： 10.2188/jea.JE20250074 　

    More details Close

    BACKGROUND: More research is needed to clarify the health effects of dietary carotenoid intakes, and this requires the use of high-quality assessments of habitual dietary intake. Cohort studies from the Tohoku Medical Megabank Organization included a self-administered food frequency questionnaire (TMM-FFQ) for community-dwelling adults. This study evaluated the validity of carotenoid intakes derived from the TMM-FFQ using serum carotenoid concentrations as the gold standard. METHODS: In Miyagi Prefecture, 88 men and 124 women aged ≥20 years voluntarily agreed to participate in the study and provided completed TMM-FFQs and blood samples in 2019 and 2021. Carotenoids examined included α-carotene, β-carotene, β-cryptoxanthin, and lycopene. Intraclass correlation coefficients (ICCs) were calculated to assess correlations between serum concentrations in 2019 and 2021. Spearman's rank correlation coefficients were calculated to evaluate the correlations between energy-adjusted dietary carotenoid intakes from the TMM-FFQ in 2021 and the average serum carotenoid concentrations in 2019 and 2021, with correction for the attenuating effect of random within-individual variation. RESULTS: The ICCs between serum concentrations over the 2 years were >0.50 for all carotenoids. Among men, correlation coefficients were 0.33 for α-carotene, 0.42 for β-carotene, 0.50 for β-cryptoxanthin, and -0.09 for lycopene. Among women, the coefficients were lower than those for men, except for lycopene: 0.11 for α-carotene, 0.23 for β-carotene, 0.21 for β-cryptoxanthin, and 0.28 for lycopene. CONCLUSIONS: The TMM-FFQ demonstrated reasonable validity for assessing intakes of α-carotene, β-carotene, and β-cryptoxanthin among men, but not among women, in the TMM cohort studies when using serum concentrations as the gold standard.

  36. 東北メディカル・メガバンク計画三世代コホート(児童および若年成人)におけるcytomegalovirusおよびEpstein-Barr virus抗体保有率

    児玉 栄一, 石黒 真美, 小原 拓, 大類 真嗣, 熊田 和貴, 工藤 久智, 荻島 創一, 中谷 直樹, 寶澤 篤, 栗山 進一, Engelberg Katja, Senko Enejda, Hendrix Laura H., 小河原 修, Diaz-Decaro John D.

    臨床とウイルス　53　(3)　240-240　2025/09

    Publisher: 日本臨床ウイルス学会

    ISSN： 0303-8092

  37. Association of Quinolone Exposure in the First-Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan. International-journal

    Kei Morishita, Taku Obara, Tomofumi Ishikawa, Ryo Obara, Takamasa Sakai, Noriyuki Iwama, Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroshi Kawame, Nariyasu Mano, Shinichi Kuriyama

    Pharmacoepidemiology and drug safety　34　(9)　e70190　2025/09

    DOI： 10.1002/pds.70190 　

    More details Close

    PURPOSE: To evaluate the risk of major congenital malformations (MCMs) associated with quinolone exposure during the first trimester of pregnancy using a large administrative database in Japan. METHODS: A large claims database was used from January 2005 to November 2019. The dates of pregnancy onset and delivery were estimated using the developed algorithm. MCMs were defined according to the International Classification of Diseases, 10th revision codes. The risk of MCM associated with first-trimester quinolone prescriptions was evaluated in women with infectious diseases diagnosed during the first trimester of pregnancy. We evaluated the overall risk of MCMs in infants, and odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by comparing women with first-trimester prescriptions of quinolones with those without antibiotic prescriptions, adjusting for covariates with propensity score overlap weights. RESULTS: The prevalence of first-trimester infectious diseases was 51.6% (47 121/91390). Among 47 121 women diagnosed with infectious diseases, 1 320 were prescribed quinolones during their first trimester of pregnancy. The overall prevalence of MCMs was 6.0% (2282/37766) in women unexposed to antibiotics and 5.9% (78/1320) in those exposed to quinolones. The first-trimester prescription of quinolone was not significantly associated with the overall MCM prevalence when overlap-weighted ORs (wOR) were calculated using propensity score overlap weights for covariates (wOR 0.904, 95% CIs 0.684-1.196). CONCLUSIONS: Prescription of quinolones in the first-trimester of pregnancy was not associated with an increased risk of MCMs in infants. Our findings may support clinical decision-making when considering quinolone use during the first-trimester of pregnancy.

  38. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. International-journal

    Taku Obara, Mami Ishikuro, Aoi Noda, Keiko Murakami, Masatsugu Orui, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Hiroko Matsubara, Hirohito Metoki, Masahiro Kikuya, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Mana Kogure, Naoki Nakaya, Junichi Sugawara, Shigeo Kure, Mika Kobayashi, Tomoko Kobayashi, Yoichi Suzuki, Hiroshi Kawame, Mika Sakurai-Yageta, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Satoshi Mizuno, Satoshi Nagaie, Soichi Ogishima, Akira Narita, Gen Tamiya, Sachie Koreeda, Fuji Nagami, Toru Tamahara, Maki Goto, Akihito Otsuki, Makiko Taira, Takanori Hidaka, Junko Kawashima, Eiichi N Kodama, Akira Uruno, Yohei Hamanaka, Hiroaki Tomita, Hiroaki Hashizume, Kenichi Noguchi, Fumiki Katsuoka, Seizo Koshiba, Kazuki Kumada, Takahiro Nobukuni, Kinuko Ohneda, Shunji Mugikura, Ritsuko Shimizu, Masataka Kambe, Yoshinobu Saito, Tadao Kobayashi, Yoko Izumi, Kengo Kinoshita, Nobuo Fuse, Nobuo Yaegashi, Atsushi Hozawa, Masayuki Yamamoto, Shinichi Kuriyama

    International journal of epidemiology　54　(5)　2025/08/18

    DOI： 10.1093/ije/dyaf148 　

  39. Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. International-journal

    Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Seizo Koshiba, Kazuki Kumada, Ikuko Motoike, Eiji Hishinuma, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kinuko Ohneda, Kengo Kinoshita, Atsushi Hozawa, Masayuki Yamamoto

    Cardiovascular diabetology　24　(1)　335-335　2025/08/14

    DOI： 10.1186/s12933-025-02849-8 　

    More details Close

    BACKGROUND: No previous studies have explored metabolites associated with both genetic predispositions to type 2 diabetes (T2DM) and T2DM onset. Therefore, we aimed to explore metabolic profiles using genetic risk to identify pathways for tailored T2DM prevention strategies. METHODS: This prospective community-based cohort study in Japan included a total of 12,461 participants aged ≥ 20 years. Genetic predictors were genome-wide and pathway-based polygenic risk scores (PRSs). We quantified 43 metabolites using nuclear magnetic resonance spectroscopy. T2DM was defined as a non-fasting glucose level of ≥ 200 mg/dL, glycated hemoglobin level ≥ 6.5%, or self-reported T2DM treatment. A modified Poisson regression model was used to examine the associations of PRSs and metabolites with T2DM incidence. Linear associations were tested using the restricted cubic spline, and mediation analysis was conducted to assess the mediating effect of metabolites on the association between PRSs and T2DM incidence. RESULTS: During the 4.3-year median follow-up period, 354 T2DM cases were identified. A higher PRS was associated with incident T2DM (relative risk [RR] 2.09, 95% confidence interval [CI], 1.68-2.60, P < 0.001, 1-standard deviation [SD] increment). The nitrogen compound transport pathway PRS was associated with incident T2DM (RR 1.32, 95% CI 1.03-1.70, P < 0.001, 1-SD increment). Fourteen metabolites like glucose, 2-ketoisocaproic acid, glutamic acid, leucine, 2-aminobutyric acid, 2-hydroxybutyric acid, valine, 3-methyl-2-oxobutyric acid, alanine, 3-hydroxybutyric acid, 3-methyl-2-oxiovaleric acid, formic acid, arginine, and tyrosine were positively associated with the risk of T2DM. Only glycine was inversely associated with the risk of T2DM. Among 43 metabolites, 14 metabolites were positively associated with PRS (P for linear trend < 0.05). 3-hydroxyisobutyric-acid, 2-Aminobutyric acid, 2-ketoisocaproic acid, 2-hydroxybutyric acid, leucine, glycine, and glucose mediated the association between PRS and incident T2DM. CONCLUSIONS: Several metabolites were found to mediate the association between PRS and incident T2DM. These findings may contribute to a better understanding of the metabolic pathways involved in genetic susceptibility to T2DM.

  40. Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study. International-journal

    Yoichi Sutoh, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Shohei Komaki, Shiori Minabe, Hideki Ohmomo, Kozo Tanno, Atsushi Hozawa, Naoki Nakaya, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Shinichi Kuriyama, Makoto Sasaki, Atsushi Shimizu

    American journal of human genetics　112　(8)　1852-1863　2025/08/07

    DOI： 10.1016/j.ajhg.2025.06.015 　

    More details Close

    The atopic march lacks early identification methods for high-risk children. In this study, we assessed whether the risk of atopic diseases in infants could be predicted using a polygenic score (PGS) for total immunoglobulin E (IgE) levels. The PGS estimated using the polygenic model generated by PRS-CS was significantly correlated with log-transformed IgE levels (ρ = 0.200, p < 2.2 × 10-16). Assessment of the risk from birth to 2 years of age in a Japanese birth cohort (n = 17,154) applying the estimated PGS revealed significantly elevated incidence risk ratios in the highest PGS quintile (Q5) compared with those in the reference quintiles (Q1-Q3) for food allergy (1.51-fold; 95% confidence interval: 1.30-1.76), atopic dermatitis (1.30-fold; 1.12-1.51), and both conditions (1.88-fold; 1.46-2.43). These findings address critical gaps in allergy and PGS research among non-European populations, suggesting the contribution of genetic predisposition to IgE production in early-onset allergic diseases and supporting the use of PGS in early intervention.

  41. Development of AI Models for Early Prediction of Preterm Birth. International-journal

    Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama, Taku Obara, Mami Ishikuro, Hiroshi Tanaka, Kengo Kinoshita, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Masatoshi Saito, Soichi Ogishima

    Studies in health technology and informatics　329　1932-1933　2025/08/07

    DOI： 10.3233/SHTI251285 　

    More details Close

    Preterm birth is one of the most important neonatal complications. In this study, we aimed to establish an artificial intelligence model for early prediction of preterm birth. Based on genetic and lifestyle data from over 20,000 neonates, we developed high-performed early prediction models up to 0.92 of AUC. Our developed models will help early prediction and appropriate intervention of preterm birth.

  42. Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from <scp>TMM BirThree</scp> Cohort Study

    Koichi Sakakibara, Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L. Bennett, Shinichi Kuriyama, Takeo Fujiwara, Pamela J. Surkan

    Journal of Diabetes Investigation　16　(10)　1900-1909　2025/07/08

    Publisher: Wiley

    DOI： 10.1111/jdi.70101 　

    ISSN： 2040-1116

    eISSN： 2040-1124

    More details Close

    ABSTRACT Introduction While social capital can prevent diabetes, these benefits can be heterogeneous with respect to socioeconomic status. We investigated the association between social capital and gestational diabetes mellitus (GDM) while examining effect modification by household income. Materials and Methods We conducted a secondary data analysis using the Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study carried out between July 2013 and March 2017. Social capital (mutual aid, social trust, informal social control, collective action) and covariates were self‐reported, while GDM diagnosis and other medical and physiological information were obtained from medical records. To assess the association between social capital and GDM, we conducted logistic regression models. We further tested for interactions between social capital and household income as well as stratified the models by income. Results Among 20,339 study participants, 700 (3.4%) were diagnosed with GDM. Multivariable logistic regression models found that social trust and collective action were associated with lower GDM prevalence, even after adjustment of covariates. When stratifying household income, however, social capital was significantly associated with the reduced risks of GDM only among participants with higher household income (OR: 0.90, 95% CI: 0.85–0.97). No significant association was observed among those with lower household income. Conclusions The health benefit of social capital on GDM prevalence was heterogeneous, and the protective effect of social capital on GDM was found only among women with higher household income. The differential impact of social capital on GDM highlights the need for targeted interventions addressing structural health inequities.

  43. Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder.

    Mika Kobayashi, Tomoko Kobayashi, Taku Obara, Akira Narita, Akimitsu Miyake, Tomohisa Suzuki, Mami Ishikuro, Masatsugu Orui, Eiichi N Kodama, Ritsuko Shimizu, Yohei Hamanaka, Yoko Izumi, Atsushi Hozawa, Nobuo Fuse, Atsuo Kikuchi, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　2025/06/12

    DOI： 10.1620/tjem.2025.J074 　

  44. 本邦におけるサイトメガロウイルス感染と流産・死産との関連

    石黒 真美, 小原 拓, 大類 真嗣, 熊田 和貴, 工藤 久智, 荻島 創一, 中谷 直樹, 寳澤 篤, 栗山 進一, Senko Enejda, Hendrix Laura H., 小河原 修, Iyer Anita, Diaz-Decaro John D., 児玉 栄一

    日本周産期・新生児医学会雑誌　61　(Suppl.1)　P343-P343　2025/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  45. 本邦におけるサイトメガロウイルス感染と流産・死産との関連

    石黒 真美, 小原 拓, 大類 真嗣, 熊田 和貴, 工藤 久智, 荻島 創一, 中谷 直樹, 寳澤 篤, 栗山 進一, Senko Enejda, Hendrix Laura H., 小河原 修, Iyer Anita, Diaz-Decaro John D., 児玉 栄一

    日本周産期・新生児医学会雑誌　61　(Suppl.1)　P343-P343　2025/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  46. Validity of single vs. multiple FFQs in ranking nutrient intake among Japanese adults: the Tohoku Medical Megabank Project. International-journal

    Mako Ogino, Ribeka Takachi, Junko Ishihara, Shiori Sugawara, Yuchie Hoshina, Kumiko Kito, Misako Nakadate, Sachiko Maruya, Aoi Suzuki, Tomoka Matsuno, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Misato Aizawa, Ippei Takahashi, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Keiko Murakami, Shinichi Kuriyama

    Asia Pacific journal of clinical nutrition　34　(3)　451-468　2025/06

    DOI： 10.6133/apjcn.202506_34(3).0019 　

    More details Close

    BACKGROUND AND OBJECTIVES: Repeating food frequency questionnaires (FFQs) within the same population was reported to improve the validity of correlation coefficient (CC). However, the enhancement of validity in ranking agreement remains underreported. Herein, we assessed the validity of energy and nutrient intake es-timates using single and multiple FFQs and their ability to rank individuals. METHODS AND STUDY DESIGN: 213 men and women aged ≥20 years were recruited from the residents participating in the Tohoku Medical Mega-bank Project (TMM) cohort studies; three FFQs were conducted in November each year from 2019 to 2021, with 12-day weighted food records (WFRs) as the reference method. Spearman's rank CCs were calculated between single or multiple FFQs estimates and those obtained through the 12-day WFR. Additionally, the ranking agreement was compared based on cross-classification. RESULTS: CCs between intake estimated using a single FFQ and 12-day WFR were moderate for several nutrients, with median CCs of 0.52 for men and 0.48 for women. CCs for multiple FFQs were slightly higher than that of single FFQ, with median CCs of 0.59 for men and 0.56 for women. Regardless of the number of FFQs, the proportion of subjects classified into the opposite extreme category was ≤5% for most nutrients. CONCLUSIONS: A single FFQ used for adults in the TMM cohort studies showed moderate validity. Estimates from multiple FFQs improved the accuracy slightly; nevertheless, this indicates that relying on a single FFQ is unlikely to result in a serious misclassifica-tion compared to using intake data from multiple FFQs over a relatively short period.

  47. Comparison of the incidence of proteinuria and changes in eGFR among febuxostat and topiroxostat users.

    Shingo Nakayama, Michihiro Satoh, Maya Toyama, Hideaki Hashimoto, Takahisa Murakami, Takuo Hirose, Taku Obara, Takefumi Mori, Hirohito Metoki

    Clinical and experimental nephrology　29　(6)　797-806　2025/06

    DOI： 10.1007/s10157-025-02630-x 　

    More details Close

    BACKGROUND: Febuxostat and topiroxostat are non-purine selective xanthine oxidoreductase inhibitors commonly used for hyperuricaemia treatment in Japan. However, comparative data on the effects of febuxostat and topiroxostat on renal function and proteinuria are limited. This study compared proteinuria incidence and changes in the estimated glomerular filtration rate (eGFR) among prevalent febuxostat and topiroxostat users. METHODS: We conducted a retrospective cohort study using databases provided by DeSC Healthcare, Inc. (Tokyo, Japan). We identified 17,446 individuals (11.8% women; mean age 67.4 years) with eGFR ≥ 30 mL/min/1.73 m2 and no history of cardiovascular disease or proteinuria at baseline. Separate analyses were performed for individuals with eGFR < 60 mL/min/1.73 m2 and those with eGFR ≥ 60 mL/min/1.73 m2. The adjusted hazard ratio (HR) for proteinuria incidence in topiroxostat users compared with febuxostat users was assessed using the Cox model. Changes in eGFR were compared between the two groups using multiple regression analysis. RESULTS: During the mean follow-up period of 1.79 years, 1,433 participants developed proteinuria. In non-diabetic individuals with eGFR ≥ 60 mL/min/1.73 m2, the adjusted HR for proteinuria incidence in topiroxostat users compared with febuxostat users was 0.60 (95% confidence interval, 0.40-0.91; p = 0.016). No significant differences were observed in eGFR changes between the two groups with eGFR < 60 and ≥ 60 mL/min/1.73 m2. CONCLUSION: Topiroxostat prevalent users had a lower risk of proteinuria than febuxostat prevalent users in non-diabetic individuals with eGFR ≥ 60 mL/min/1.73 m2. Our findings suggest that topiroxostat might be more effective than febuxostat in preventing proteinuria in non-diabetic individuals with eGFR ≥ 60 mL/min/1.73 m2.

  48. Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large-scale community-based cohort study. International-journal

    Masatsugu Orui, Mami Ishikuro, Taku Obara, Aoi Noda, Genki Shinoda, Keiko Murakami, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Tomoko Nishimura, Keiko Tanaka, Yoshihiro Miyake, Atsushi Hozawa, Kenji J Tsuchiya, Shinichi Kuriyama

    PCN reports : psychiatry and clinical neurosciences　4　(2)　e70095　2025/06

    DOI： 10.1002/pcn5.70095 　

    More details Close

    AIM: Autism spectrum disorder (ASD) is a neurodevelopmental condition clinically characterized by abnormalities in eye contact during social interactions. Eye-tracking systems have been used to screen individuals with ASD by capturing atypical eye gaze patterns of diagnostic significance, such as reduced duration of eye gaze fixation on social information. However, most prior studies have focused on the screening accuracy of eye-tracking systems in children already diagnosed with ASD, with few longitudinal assessments conducted on a large scale. This large-scale, longitudinal, community-based study aimed to analyze the association between specific neurodevelopmental symptoms and the duration of eye gaze fixation on social information within a community-based setting. METHODS: A longitudinal study involving 2101 participants utilized a generalized linear model (GLM) to examine associations between the duration of eye gaze fixation on social information at age 4 years and subscale scores of the Strengths and Difficulties Questionnaire (SDQ) at ages 6-7. RESULTS: GLM analysis revealed that shorter durations of eye gaze fixation on social information at age 4 years were significantly associated with emotional problems and peer problems, and with hyperactivity/inattention attention-deficit hyperactivity disorder (ADHD) at ages 6-7 years. CONCLUSION: These findings demonstrate the ability to detect not only peer problems characteristic of ASD but also hyperactivity/inattention characteristic of ADHD longitudinally, which it might be related to the comorbidity of ASD and ADHD. This preliminary study highlights the potential for neurodevelopmental screening; however, further research is needed to validate the accuracy of these methods.

  49. Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes. International-journal

    Hisashi Ohseto, Mami Ishikuro, Geng Chen, Ippei Takahashi, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama

    Scientific reports　15　(1)　18924-18924　2025/05/29

    DOI： 10.1038/s41598-025-03652-x 　

    More details Close

    Adverse pregnancy outcomes (APOs) affect approximately 20% pregnant women, and their incidence is increasing. The aim of this study was to investigate the effect of cardiovascular health (CVH) during pregnancy on APOs. We analyzed data from 14,930 pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. CVH status during pregnancy was assessed using the eight components of Life's Essential 8. APOs were defined as composite outcomes encompassing preeclampsia, gestational diabetes mellitus, preterm birth, and small for gestational age. The numbers of participants with high, moderate, and low CVH status were 2891 (19.4%), 11,498 (77.0%), and 541 (3.6%), respectively. Poisson regression analyses with robust error variance, which adjusted for maternal age at conception, alcohol consumption, conception via in vitro fertilization, parity, psychological distress, social isolation, and household income, showed a positive association between moderate and low CVH levels and APOs (risk ratio and 95% confidence interval 1.15 [1.03-1.28] and 2.14 [1.78-2.58], respectively). Among pregnant women with low CVH, those who reported social isolation had a higher prevalence of APOs than did those without social isolation (36.4% vs. 27.4%). This difference was attenuated for pregnant women with high CVH status (13.6% vs. 13.1%). In conclusion, CVH status may be useful for assessing the risk of APOs. Socially isolated pregnant women are more vulnerable to the effects of low CVH status.

  50. Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study. International-journal

    Hisashi Ohseto, Mami Ishikuro, Taku Obara, Akira Narita, Ippei Takahashi, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Gen Tamiya, Shinichi Kuriyama

    Scientific reports　15　(1)　13743-13743　2025/04/21

    DOI： 10.1038/s41598-025-97291-x 　

    More details Close

    Genomic information from pregnant women and the paternal parent of their fetuses may provide effective biomarkers for preeclampsia (PE). This study investigated the association of parental polygenic risk scores (PRSs) for blood pressure (BP) and PE with PE onset and evaluated predictive performances of PRSs using clinical predictive variables. In the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, 19,836 participants were genotyped using either Affymetrix Axiom Japonica Array v2 (further divided into two cohorts-the PRS training cohort and the internal-validation cohort-at a ratio of 1:2) or Japonica Array NEO (external-validation cohort). PRSs were calculated for systolic BP (SBP), diastolic BP (DBP), and PE and hyperparameters for PRS calculation were optimized in the training cohort. PE onset was associated with maternal SBP-, DBP-, and PE-PRSs and paternal SBP- and DBP-PRSs only in the external-validation cohort. Meta-analysis revealed overall associations with maternal PRSs but highlighted significant heterogeneity between cohorts. Maternal DBP-PRS calculated using "LDpred2" presented the most improvement in prediction models and provided additional predictive information on clinical predictive variables. Paternal DBP-PRS improved prediction models in the internal-validation cohort. In conclusion, Parental PRS, along with clinical predictive variables, is potentially useful for predicting PE.

  51. Sex difference of genetic risk in the prevalence of atrial fibrillation. International-journal

    Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

    Heart rhythm　2025/03/23

    DOI： 10.1016/j.hrthm.2025.03.1974 　

    More details Close

    BACKGROUND: Early detection and management of atrial fibrillation (AF) are crucial. Combined models incorporating genetic risks and clinical risks have been developed to improve predictive ability. Although sex differences have been reported in many aspects of AF, sex differences in genetic risk have not been studied. OBJECTIVE: To assess the sex difference in the effect of AF-PRS on AF prevalence using cross-sectional data from the Tohoku Medical Megabank Project Community-Based Cohort Study in Japan. METHODS: Polygenic risk score for AF (AF-PRS) and Cohorts for Heart and Aging Research in Genomic Epidemiology AF (CHARGE-AF) score were used for genetic AF risks and clinical AF risks, respectively. Sex differences in the association of AF-PRS with the prevalence of AF were evaluated. RESULTS: Among 16,853 participants (mean age, 63.4 years and 30.7% men), the prevalence of AF was 4.9% in men and 1.1% in women. In the group with high AF-PRS and high CHARGE-AF score, the odds ratio for AF was highest in men and women (8.2 in men and 9.4 in women), compared to that in the group with low AF-PRS and low CHARGE-AF score. Integrating AF-PRS into the CHARGE-AF score significantly enhanced the area under the curve of receiver operating characteristic for AF in men (from 0.639 to 0.749) but not in women (from 0.710 to 0.733). CONCLUSION: Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.

  52. Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. International-journal

    Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Yuki Nagata, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Margaret A Taub, Pamela J Surkan, Shinichi Kuriyama, Takeo Fujiwara

    Journal of human genetics　2025/03/21

    DOI： 10.1038/s10038-025-01330-4 　

    More details Close

    Gestational diabetes mellitus (GDM) is common in Japanese women, posing serious risks to mothers and offspring. This study investigated the influence of maternal genotypes on the risk of GDM and examined how these genotypes modify the effects of psychological and dietary factors during pregnancy. We analyzed data from 20,399 women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort. Utilizing two customized SNP arrays for the Japanese population (Affymetrix Axiom Japonica Array v2 and NEO), we performed a meta-analysis to combine the datasets. Gene-environment interactions were assessed by modeling interaction terms between genome-wide significant single nucleotide polymorphisms (SNPs) and psychological and dietary factors. Our analysis identified two SNP variants, rs7643571 (p = 9.14 × 10-9) and rs140353742 (p = 1.24 × 10-8), located in an intron of the MDFIC2 gene, as being associated with an increased risk of GDM. Additionally, although there were suggestive patterns for interactions between these SNPs and both dietary factors (e.g., carbohydrate and fruit intake) and psychological distress, none of the interaction terms remained significant after Bonferroni correction (p < 0.05/8). While nominal significance was observed in some models (e.g., psychological distress, p = 0.04), the data did not provide robust evidence of effect modification on GDM risk once adjusted for multiple comparisons. These findings reveal novel genetic associations with GDM in Japanese women and highlight the importance of gene-environment interactions in its etiology. Given that previous genome-wide association studies (GWAS) on GDM have primarily focused on Western populations, our study provides new insights by examining an Asian population using a population-specific array.

  53. Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. International-journal

    Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

    Nutrition (Burbank, Los Angeles County, Calif.)　135　112739-112739　2025/03/08

    DOI： 10.1016/j.nut.2025.112739 　

    More details Close

    OBJECTIVES: Adiposity rebound (AR) corresponds to the start of the second rise in the body mass index curve during infant growth. Early AR (before age 5) confers increased risk of adiposity and metabolic disorders but is less likely to occur in breastfed infants. Although lipids in breast milk are important in child growth, information is limited regarding which lipids are involved in AR. The object of this study was to explore the association between breast milk lipids and AR status in children. METHODS: We designed a case-control study of 184 mother-child pairs (AR cases: n = 93; controls: n = 91) included from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Breast milk was collected 1 month postpartum and comprehensive lipid analysis was performed. Partial least square-discriminant analysis was used to explore candidate lipids, and multivariable logistic regression analysis was used to evaluate associations with the AR status of children. RESULTS: We detected 667 lipid molecules in 12 lipid classes in breast milk. Partial least square-discriminant analysis revealed the association of fatty acid-hydroxy fatty acid (FAHFA) and cholesterol ester (ChE) with AR status. Multivariable logistic regression analysis showed that in pairs with exclusive breastfeeding at 1 month postpartum, FAHFA (odds ratio 1.57 [95% confidence interval, 1.06-2.32]) was positively associated with early AR, and ChE (odds ratio 0.55 [95% confidence interval, 0.36-0.86]) was negatively associated. CONCLUSIONS: Breast milk lipids (FAHFA, ChE) associated with the AR status of children, indicating the potential to regulate a child's adiposity and possible metabolic disorders in adulthood.

  54. Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case-Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Tomoko Tanaka, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

    The Journal of nutrition　2025/03/07

    DOI： 10.1016/j.tjnut.2025.02.024 　

    More details Close

    BACKGROUND: Adiposity rebound (AR) is the point when the body mass index (BMI) begins to rise again during early childhood. Early AR (before age 5) is associated with a higher risk of lifelong obesity and metabolic disorders and may be influenced by breastfeeding. Although human milk oligosaccharides (HMOs) in breast milk are crucial for child growth, their association with AR status has not been studied. OBJECTIVE: To explore breast milk HMO compositions and molecules associated with AR status in children. METHODS: In this case-control study, we included 184 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study (93 AR cases, 91 controls). Breast milk was collected 1 month postpartum, and the concentration of 15 HMO molecules and alpha-diversity index (Inverse Simpson index) were quantified. Wilcoxon's rank-sum test and partial least squares-discriminant analysis (PLS-DA) identified candidate HMOs, and multivariable logistic regression analysis evaluated associations between candidate HMOs and AR status. Analyses were stratified by maternal secretor status (secretor or non-secretor). RESULTS: In secretor mothers, multivariable logistic regression showed that the Inverse Simpson index (OR, 0.54 [95% CI, 0.36-0.82]), sum of sialic acid-bound HMOs (0.61 [0.41-0.91]), and 3'-sialyllactose (0.67 [0.46-0.98]) were inversely associated with early AR in a fully adjusted model. A trend of interaction between sialyl-lacto-N-tetraose a (LSTa) and maternal secretor status on AR was observed in a fully adjusted model (P-value for interaction = 0.051). CONCLUSIONS: Alpha diversity, sialic acid-bound HMOs, and 3'SL may be involved in inhibiting AR in children of secretor mothers, and a trend of interactive effect of LSTa among maternal secretor status on AR was indicated. These findings offer novel perspectives on the associations between breastfeeding and a child's adiposity as well as potential metabolic disorders later in life. REGISTRY NUMBER/WEBSITE: https://www.umin.ac.jp/ (trial registration number: UMIN000047160).

  55. Impact of maternal smoking and secondhand smoke exposure during singleton pregnancy on placental abruption: analysis of a prospective cohort study (the Japan Environment and Children's Study). International-journal

    Hikaru Karumai-Mori, Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

    BMJ open　15　(3)　e089499　2025/03/04

    DOI： 10.1136/bmjopen-2024-089499 　

    More details Close

    OBJECTIVES: This study aimed to investigate the association and population-attributable fraction (PAF) of maternal smoking and secondhand smoke (SHS) exposure during pregnancy with placental abruption. DESIGN: Prospective cohort study. SETTING: 15 regional centres in Japan. PARTICIPANTS: Pregnant women registered between January 2011 and March 2014 from the Japan Environment and Children's Study. OUTCOME MEASURES: Data were transcribed from medical records and two self-administered questionnaires. The outcome measure was the incidence of placental abruption. Maternal smoking exposure during pregnancy was categorised based on the number of cigarettes smoked (≤10 or ≥11 cigarettes per day). SHS exposure during pregnancy was evaluated by frequency and duration (almost never or never, 1-3 days/week and/or <1 hour/day and 4-7 days/week and ≥1 hour/day). A modified Poisson regression model, adjusted for known placental abruption risk factors, calculated the risk ratio (RR) and PAF for placental abruption with a 95% Cl. RESULTS: Of the 81 974 eligible pregnant women, pregnant women smoking ≥11 cigarettes/day during pregnancy had a significantly higher risk of placental abruption. The adjusted RR (aRR) was 2.21 (95% CI 1.21 to 4.06), and the adjusted PAF (aPAF) was 1.90% (95% CI 0.09 to 3.71%). Pregnant women among never-smokers with SHS exposure of 4-7 days/week and ≥1 hour/day had a significantly higher risk (aRR: 2.34, 95% CI 1.29 to 4.28), and the aPAF was 1.89% (95% CI -0.05 to 3.83). Additionally, pregnant women among those who smoked during pregnancy with similar SHS exposure had a significantly higher risk (aRR: 2.21, 95% CI 1.30 to 3.76), with the aPAF of 2.29% (95% CI 0.11 to 4.48). CONCLUSIONS: Maternal smoking and SHS exposure during pregnancy significantly contribute to the risk of placental abruption in Japan. Therefore, preventive interventions and measures to reduce exposure are required to prevent placental abruption.

  56. Impact of Telework on Health and Lifestyle Changes During the COVID-19 Pandemic in Japan.

    Genki Shinoda, Fumiko Matsuzaki, Fumihiko Ueno, Mami Ishikuro, Keiko Murakami, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

    The Tohoku journal of experimental medicine　2025/02/13

    DOI： 10.1620/tjem.2025.J014 　

  57. Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children

    Chikana Kawaguchi, Mami Ishikuro, Ryota Saito, Keiko Murakami, Aoi Noda, Genki Shinoda, Misato Aizawa, Hisashi Ohseto, Noriyuki Iwama, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

    The Journal of Clinical Endocrinology &amp; Metabolism　2025/01/20

    Publisher: The Endocrine Society

    DOI： 10.1210/clinem/dgae825 　

    ISSN： 0021-972X

    eISSN： 1945-7197

    More details Close

    Abstract Background The association of maternal hyperglycemia with childhood developmental delay has been examined; however, only 2 studies used maternal blood glucose level as a continuous variable as an exposure. A present study aimed to investigate the influence of maternal fasting plasma glucose (mFPG) level in early gestation on developmental delay in children. Methods This cohort study included 1541 mother–child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. mFPG level before 24 gestational weeks was obtained as a continuous and categorical variable. Developmental delay in 2-year-old children was assessed by mothers using the Ages and Stages Questionnaire (third edition). Associations between mFPG level and developmental delay in children were evaluated using multiple logistic regression analyses. Results The prevalence of mFPG level ≥95 mg/dL was 5.2%. At 2 years old, 15.1% of the children had developmental delays. mFPG level as a continuous variable was not associated with an increased risk of developmental delay across the 5 domains in children [adjusted odds ratio (aOR), 95% confidence interval (CI): 1.004, 0.990-1.018]. mFPG level ≤70 mg/dL was associated with developmental delay across 5 domains (aOR, 95% CI: 0.464, 0.229-0.943) in children than that with a mFPG level 71 to 94 mg/dL. No association was found between mFPG level ≤70 mg/dL and ≥95 mg/dL and developmental delay in any domains among children. Conclusion mFPG level in early gestation was not associated with an increased risk of any developmental delays in 2-year-old children.

  58. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation.

    Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Masato Takase, Kotaro Nochioka, Kai Susukita, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

    Circulation journal : official journal of the Japanese Circulation Society　2025/01/11

    DOI： 10.1253/circj.CJ-24-0780 　

    More details Close

    BACKGROUND: The primary prevention of atrial fibrillation (AF), which increases mortality through complications including stroke and heart failure, is important. Excessive salt intake and low potassium intake are risk factors for cardiovascular disease; however, their association with AF remains inconclusive. This study investigated the association between sodium- and potassium-related urinary markers and AF prevalence. METHODS AND RESULTS: Data from the Tohoku Medical Megabank Project Community-based Cohort Study were used in this cross-sectional study. The urinary sodium-to-potassium (Na/K) ratio and estimated 24-h sodium and potassium excretion were calculated using spot urine samples and categorized into quartiles (Q1-Q4). The prevalence of AF was the primary outcome. Of the 26,506 participants (mean age 64.8 years; 33.2% males) included in this study, 630 (2.4%) had AF. Using Q1 as the reference group, the odds ratios for AF prevalence in Q4 were 1.35 (95% confidence interval [CI] 1.07-1.73) and 1.59 (95% CI 1.20-2.12) for 24-h estimated urinary Na/K ratio and estimated 24-h sodium excretion, respectively. Estimated 24-h potassium excretion was not associated with AF prevalence. CONCLUSIONS: AF prevalence was positively associated with the urinary Na/K ratio and estimated 24-h urinary sodium excretion, but not with estimated 24-h urinary potassium excretion. Although further prospective studies are warranted, the findings of this study suggest that salt intake may be a modifiable risk factor for AF.

  59. Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

    Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

    Journal of diabetes investigation　2025/01/11

    DOI： 10.1111/jdi.14400 　

    More details Close

    AIMS: This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM). METHODS: In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30-34.9 years. RESULTS: Higher maternal age was associated with higher odds of early and late GDM (P-value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35-39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134-1.725) and 2.494 (95% CI: 1.828-3.402), respectively. The aORs for late GDM with maternal age of 35-39 years and ≥40 were 1.603 (95% CI: 1.384-1.857) and 2.276 (95% CI: 1.798-2.881), respectively. CONCLUSIONS: Higher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM.

  60. Inclination of antidepressant medication continuation during pregnancy between 2012 and 2023 in Japan: A cohort study. International-journal

    Tomofumi Ishikawa, Takamasa Sakai, Aoi Noda, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, M Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

    Journal of affective disorders　2025/01/10

    DOI： 10.1016/j.jad.2025.01.044 　

    More details Close

    BACKGROUND: As multiple Japanese academic societies have recently issued treatment guidelines for perinatal antidepressant treatments, it is considered worthwhile to evaluate the latest trends and continuation of antidepressant medication during pregnancy to optimize antenatal prescriptions. METHODS: The prevalence, trend, and continuation of antidepressant use during pregnancy in Japan from 2012 to 2023 were evaluated, using a large administrative claims database, in women whose pregnancies ended in live births. Annual changes were evaluated using a multivariate logistic regression model adjusted for maternal age at delivery. RESULTS: Of 179,797 women with a mean maternal age at delivery of 32.5 years, 1870 (1.04 %) were prescribed antidepressants during pregnancy. The prevalence significantly increased (P < 0.0001) from 0.63 % in 2012 to 1.67 % in 2023. Antidepressants were prescribed to 1730 women (0.96 %) during the first trimester. Of these, 670 (38.7 %) were antidepressant continuers throughout pregnancy, showing a significant increase (P < 0.0001) from 19.51 % in 2012 to 50.70 % in 2023. The most frequently prescribed class of antidepressants during pregnancy was serotonin reuptake inhibitors (0.74 %), especially sertraline (0.33 %) and escitalopram (0.23 %), with a significant increase in their annual prevalence. LIMITATIONS: Prescriptions for women whose pregnancies ended in abortion or stillbirth could not be evaluated. CONCLUSIONS: Given that antidepressant use and its continuation during pregnancy have become more common, it is important to further disseminate knowledge of the guidelines to healthcare professionals and women of childbearing age, including the promotion of preconception care and shared decision-making.

  61. 日本人集団を対象とした皮質下構造の関連遺伝子の探索

    篠田 元気, 小原 拓, 高橋 一平, 大瀬戸 恒志, 野田 あおい, 石黒 真美, 村上 慶子, 大類 真嗣, 中谷 直樹, 成田 暁, 田宮 元, 麦倉 俊司, 布施 昇男, 寳澤 篤, 鈴木 匡子, 栗山 進一

    Journal of Epidemiology　35　(Suppl.)　105-105　2025/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  62. 東北メディカル・メガバンク機構(宮城)における循環器疾患発症調査の進捗

    畑中 里衣子, 時岡 紗由理, 千葉 一平, 小暮 真奈, 中谷 久美, 高瀬 雅仁, 石黒 真美, 薄田 海, 大類 真嗣, 後岡 広太郎, 目時 弘仁, 菊谷 昌浩, 小原 拓, 中谷 直樹, 栗山 進一, 寳澤 篤

    Journal of Epidemiology　35　(Suppl.)　123-123　2025/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  63. Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study. International-journal

    Satoko Suzuki, Ryutaro Arita, Taku Obara, Tomofumi Ishikawa, Tadaharu Kunitoki, Takamasa Sakai, Aoi Noda, Genki Shinoda, Mami Ishikuro, Masatsugu Orui, Shinichi Kuriyama, Minoru Ohsawa, Ken Haneda, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

    Frontiers in pharmacology　16　1562724-1562724　2025

    DOI： 10.3389/fphar.2025.1562724 　

    More details Close

    INTRODUCTION: Traditional Japanese (Kampo) medicine containing Prunus persica kernel (KPK) is prescribed for treating menstrual- and pregnancy-related symptoms. However, no safety information is available regarding its use in pregnant women. In this study, we examined the associations of KPK prescriptions during the first trimester of pregnancy with preterm births and major congenital malformations (MCMs) in newborns. METHODS: From a large-scale Japanese health insurance claims database, we included pregnant women enrolled with the same healthcare insurer from 3 months before pregnancy to the date of delivery, who gave birth between 2010 and 2019, and whose data were linked to their infants. We then selected pregnant women who were prescribed KPK during the first trimester as the exposure group, and those who were prescribed tokishakuyakusan (TSS), commonly used for pregnancy-related symptoms, during the same period as controls. The association between KPK prescriptions and preterm birth or MCM among infants was examined using a multivariate logistic regression analysis. RESULTS: Of the 75,398 infants, TSS and KPK was prescribed to 2,548 (3.38%) and 283 (0.38%) women during the first trimester, respectively. In the TSS group, 311 of 2,491 infants (12.5%) experienced preterm births, whereas 40 of 283 infants (14.1%) in the KPK group experienced preterm births. The risk of preterm birth in the KPK group was not significantly different from that in the TSS group (adjusted risk ratio, 1.122; 95% confidence interval, 0.827-1.521). In the TSS group, 157 of 2,491 infants (6.3%) had MCMs, whereas 15 of 283 infants (5.3%) in the KPK group had MCMs. There was no significant difference in the incidence of MCM in the first year after birth between infants in the KPK and TSS groups (adjusted odds ratio, 0.820; 95% confidence interval, 0.475-1.415). CONCLUSION: There was no significant difference in the risk of preterm birth or MCMs between pregnant women prescribed KPK and those prescribed TSS during the first trimester.

  64. Respiratory syncytial virus infection, non-respiratory syncytial virus respiratory infections, and later wheezing. International-journal

    Ippei Takahashi, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Yoshikazu Nakayama, Atsushi Momose, Naho Tsuchiya, Satoshi Nagaie, Soichi Ogishima, Gen Tamiya, Nobuo Fuse, Atsushi Hozawa, Junichi Sugawara, Shigeo Kure, Shinichi Kuriyama

    Pediatrics international : official journal of the Japan Pediatric Society　67　(1)　e70050　2025

    DOI： 10.1111/ped.70050 　

    More details Close

    BACKGROUND: Studies investigating whether respiratory syncytial virus (RSV) infection, non-RSV respiratory infections, respiratory-related disorders, and non-respiratory-related disorders are associated with subsequent wheezing are limited in Japan. We aimed to elucidate the relationship between hospitalization for RSV infection, non-RSV respiratory infections, respiratory-related disorders, as well as non-respiratory-related disorders and subsequence wheezing in Japanese children. METHODS: This study included 7340 children and was conducted under the TMM BirThree Cohort Study (Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study). Data was collected from birth records and questionnaires. We categorized hospitalization history into five categories: "no hospitalization," hospitalizations for "RSV infection," "non-RSV respiratory infections," "respiratory-related disorders," and "non-respiratory-related disorders." The association of the five categories with later wheezing at 3 years of age was evaluated using multivariable logistic regression analysis. RESULTS: After adjusting for covariates, an association was shown between hospitalization under 2 years of age and later wheezing (odds ratio [OR] = 2.78; 95% confidence interval [CI] = 1.97-3.88 for "RSV infection"; OR = 2.61; 95% CI = 1.44-4.57 for "non-RSV respiratory infections"; and OR = 3.33; 95% CI = 2.43-4.54 for "respiratory-related disorders"). CONCLUSION: Hospitalization of children under 2 years of age for RSV infection as well as non-RSV respiratory infections and respiratory-related disorders were associated with subsequent wheezing.

  65. Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. International-journal

    Nobuo Fuse, Hayato Anzawa, Miyuki Sakurai, Ikuko N Motoike, Satoshi Nagaie, Tomohiro Nakamura, Akiko Miyazawa, Eiichi N Kodama, Masatsugu Orui, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Makiko Taira, Ritsuko Shimizu, Naoki Nakaya, Mami Ishikuro, Taku Obara, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Kazuki Kumada, Shinichi Kuriyama, Atsushi Hozawa, Yoko Izumi, Kengo Kinoshita, Masayuki Yamamoto

    Ophthalmology science　5　(5)　100821-100821　2025

    DOI： 10.1016/j.xops.2025.100821 　

    More details Close

    PURPOSE: This study was conducted to elucidate the distribution and determinants of ocular biometric parameters and to assess the association between intraocular pressure (IOP) and single nucleotide polymorphisms (SNPs) in the Japanese population-based genome cohort studies. DESIGN: Cross-sectional analysis involving genome-wide association studies (GWASs). PARTICIPANTS: In total, 22 150 participants aged >18 years from the population cohort (Community-Based Cohort [CommCohort]) and 11 302 participants from the Birth and Three-Generation (BirThree) Cohort of the Tohoku Medical Megabank Organization Eye Study were examined. METHODS: Participant underwent interviews, ophthalmic and physiological examinations, laboratory tests, and microarray analyses. Genome-wide association studies were conducted in the CommCohort (discovery stage) and the BirThree Cohort (replication stage), followed by a meta-analysis. Associations of SNPs and IOP were evaluated using a genome-wide significance threshold (5 × 10- 8). MAIN OUTCOME MEASURES: Association of SNPs with IOP and distributions of IOP by sex and age. RESULTS: In the discovery stage, the mean IOP of the right and left eye was 13.95 and 14.02 mmHg, respectively. In the replication stage, the corresponding values were 14.32 and 14.27 mmHg, respectively. A significant age-related reduction in IOP was observed in both stages (P < 0.001). Genome-wide association studies identified 573 and 2 genome-wide significant SNPs in the discovery and replication stages, respectively. Meta-analysis revealed 1601 significant SNPs across 21 loci on 11 chromosomes (Chrs). Of these loci, 17 were previously known to be associated with IOP or glaucoma, while four-septin-8 (SEPT8; Chr5), aldehyde dehydrogenase 2 (ALDH2; Chr12), collagen type VI alpha 2 chain (COL6A2; Chr21), and Wnt family member 7B (WNT7B; Chr22)-were newly identified. CONCLUSIONS: This large-scale GWAS in a Japanese population identified 21 loci associated with IOP, including 4 novel loci. The findings highlight both genetic similarities and population-specific variations in SNPs influencing IOP and provide valuable insights to enhance eye health care, including glaucoma management. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

  66. Differential coronary heart disease risk among antihypertensive and lipid-lowering medication users versus non-users: A real-world data analysis. International-journal

    Michihiro Satoh, Shingo Nakayama, Hideaki Hashimoto, Maya Toyama, Yutaro Iwabe, Takahito Yagihashi, Takahisa Murakami, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki

    Journal of clinical lipidology　19　(2)　294-302　2025

    DOI： 10.1016/j.jacl.2024.12.006 　

    More details Close

    BACKGROUND: We aimed to precisely quantify the risk of coronary heart disease (CHD) among antihypertensive medication users compared to non-users. We similarly assessed the potential CHD risk among lipid-lowering medication users. METHODS: This retrospective cohort study used claims and health checkup data from 2014 to 2021 provided by DeSC Healthcare, Inc. We used percutaneous coronary intervention (PCI) risk as a proxy for the CHD outcome. RESULTS: Among the 1,740,153 participants without a history of cardiovascular and kidney diseases, 3803 underwent PCI during a mean follow-up of 3.2 years. The Cox model with health insurers as the stratified factor showed that blood pressure (BP) classification according to the hypertension guidelines was linearly associated with PCI risk. In contrast, this association was weaker in antihypertensive medication users than in nonusers. After restricting to 1,309,460 participants with BP <140/<90 mm Hg, the antihypertensive medication users had a 1.51 (95% CI: 1.37-1.66) times higher PCI risk than nonusers even after adjusting for baseline characteristics including systolic BP. This was consistent in all subgroups stratified by characteristics including body mass index, drinking status, diabetes, systolic BP, and follow-up years. Meanwhile, the use of lipid-lowering medications was not associated with PCI risk (hazard ratio: 0.98, 95% CI: 0.88-1.09 in 1,221,390 patients with low-density lipoprotein cholesterol <3.62 mmol/L [<140 mg/dL]). CONCLUSIONS: Especially for hypertension, it is important not only to lower BP with medication but also to avoid the need for medication through early prevention and lifestyle changes.

  67. Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. International-journal

    Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Takahiro Tabuchi, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Takahito Nasu, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Yoko Izumi, Atsushi Hozawa

    BMJ public health　3　(1)　e001746　2025/01

    DOI： 10.1136/bmjph-2024-001746 　

    More details Close

    OBJECTIVES: Previous studies have assessed the impact of active smoking on mortality using the population-attributable fraction (PAF). However, these studies have not included second-hand smoking (SHS), potentially underestimating smoking's impact. We compared the PAF from active smoking alone with the PAF, including SHS exposure. DESIGN: Prospective cohort study. SETTING: A community-based cohort study in Japan. PARTICIPANTS: 40 796 participants aged ≥20 years. MAIN OUTCOME MEASURES: SHS was defined as inhaling someone else's cigarette smoke at the workplace or home in the past year. We classified smoking status and SHS into ten categories: never-smoker without SHS, never-smoker with SHS, past smoker without SHS, past smoker with SHS, current smoker 1-9 cigarettes/day without SHS, current smoker 1-9 cigarettes/day with SHS, 10-19 cigarettes/day without SHS, 10-19 cigarettes/day with SHS, ≥20 cigarettes/day without SHS and ≥20 cigarettes/day with SHS. The main outcome was all-cause mortality. RESULTS: During the median follow-up period of 6.5 (5.7-7.5) years, 788 men and 328 women died. For men, compared with never-smokers without SHS, past smokers without SHS (HR, 1.39 [95% CI, 1.11 to 1.73]) and past smokers with SHS (HR, 1.48 (95% CI, 1.10 to 2.00)) were associated with all-cause mortality. For women, never-smokers with SHS had a significantly higher risk of all-cause mortality (HR, 1.36 (95% CI, 1.00 to 1.84)). Without considering SHS, 28.0% and 2.3% of all-cause mortality in men and women, respectively, were attributable to past and current smoking. Including SHS, PAF increased to 31.3% in men and 8.4% in women. CONCLUSIONS: We clarified that smoking's impact was underestimated by not accounting for SHS, especially in women. Information on SHS is crucial for understanding smoking's health impact. This study supports the importance of avoiding smoking and preventing SHS.

  68. Pregnancy and Postpartum Trends in Self-Measured Blood Pressure and Derived Indices: The BOSHI Study. International-journal

    Seiya Izumi, Misato Nishimura, Noriyuki Iwama, Hasumi Tomita, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Takahisa Murakami, Michihiro Satoh, Takuo Hirose, Masatoshi Saito, Takayoshi Ohkubo, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

    Journal of clinical hypertension (Greenwich, Conn.)　27　(1)　e14949　2025/01

    DOI： 10.1111/jch.14949 　

    More details Close

    In this study, we aimed to reveal the trends of self-measured blood pressure (SMBP) and SMBP-derived indices during pregnancy and the postpartum period. The Babies and Their Parents Longitudinal Observation in Suzuki Memorial Hospital in the Intrauterine Period (BOSHI) Study is a prospective cohort study in Japan. Participants were instructed to measure SMBP daily during pregnancy and for 1 month after delivery. Among 237 participants with normotensive blood pressure (BP) during pregnancy and the postpartum period who were analyzed using mixed-effects models for repeated measures, the SMBP was measured, on average, 14.3 times from the day before delivery to 28 days postpartum. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the day before delivery were 110.6 ± 1.0 and 68.1 ± 0.8 mmHg (estimate ± standard error). Postpartum BP increased from postpartum Days 3-8 in SBP and from Days 3-22 in DBP, compared to that on the day before delivery. The SBP and DBP were 4.9 and 4.7 mmHg higher on postpartum Days 8 and 7 than the day before pregnancy, respectively. During pregnancy, the pulse rate (PR) showed an inverted U-shaped trend and then sharply increased rapidly until the first postpartum day after delivery. The Shock Index showed a similar trend to that of the PR, decreased from labor until postpartum Day 8, and plateaued thereafter. The double product peaked during labor, remained higher than the prelabor levels for approximately 10 days, and then decreased in the postpartum period.

  69. Validity of a self-administered food frequency questionnaire for genomic and omics research among pregnant women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, Ribeka Takachi, Shiori Sugawara, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Masayuki Yamamoto, Shinichi Kuriyama

    Journal of epidemiology　2024/12/21

    DOI： 10.2188/jea.JE20240293 　

    More details Close

    BACKGROUND: The Tohoku Medical Megabank Project has initiated the Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) including genomic and omics investigations, and conducted a self-administered food frequency questionnaire with the response option "constitutionally unable to eat or drink it" for individual food items (TMM-FFQ) for pregnant women. This study evaluated the validity of the TMM-FFQ among pregnant women. METHODS: Participants comprised 122 pregnant women aged ≥20 years residing in Miyagi Prefecture who completed weighed food records (WFRs) for 3 days as reference intake and the TMM-FFQ during mid-pregnancy. Correlations between nutrient or food group intakes based on the WFR and the TMM-FFQ were calculated using Spearman's rank correlation coefficients (CCs), adjusting for energy intake and correcting for random within-individual variation of WFR. Cross-classification was also conducted according to quintiles using the WFR and TMM-FFQ data. RESULTS: The percentages of participants who chose the "constitutionally unable to eat or drink it" option were >3% for seven food and drink items. CCs were >0.30 for 31 nutrients; the median across energy and 44 nutrients was 0.41. CCs were >0.30 for 14 food groups; the median across 20 food groups was 0.35. The median percentages of cross-classification into exact plus adjacent quintiles and extreme quintiles were 63.1% and 3.3% for energy and nutrients and 61.9% and 4.1% for food groups, respectively. CONCLUSIONS: The validity of the TMM-FFQ compared with the WFR was reasonable for certain nutrients and food groups among pregnant women in the TMM BirThree Cohort Study.

  70. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self-harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama

    PCN reports : psychiatry and clinical neurosciences　3　(4)　e70025　2024/12

    DOI： 10.1002/pcn5.70025 　

    More details Close

    AIM: The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self-harm ideation (SHI) at 1 month postpartum. METHODS: A sample of 12,358 postpartum women answered the EPDS and questionaries at 1, 6, and 12 months postpartum longitudinally. RESULTS: For participants with postpartum depression (PPD; EPDS total score ≥9) and SHI (SHI sub-score ≥1) at 1 month postpartum, the risk of depression at 6 and 12 months postpartum (odds ratio [95% confidence interval] at 6 and 12 months postpartum: 20.03 [16.8-23.8] and 14.55 [12.3-17.2], respectively) was higher than for those with PPD but without SHI at 1 month postpartum (OR: 8.57 [7.36-10.0], and 6.24 [5.38-7.24], respectively). Additionally, SHI even without depressive symptoms at 1 month postpartum is also a risk for depression at 6 and 12 months postpartum. To support our longitudinal evaluation of depression at 6 and 12 months postpartum, these related factors were examined: traumatic events or relocations after the Great East Japan Earthquake, employment status, household income, personality traits, sleep status, psychological distress, and social networks. The result showed employment status, low household income and poor social networks were significantly associated with depression at 12 months postpartum but not at 6 months postpartum. CONCLUSION: This study showed a high risk of depression at 6 and 12 months postpartum for those who had depressive symptoms with SHI at 1 month postpartum. Our findings may contribute to the precise evaluation of depression at 6 and 12 months postpartum while considering sleep status, psychological distress and social network during pregnancy.

  71. 血管型Ehlers-Danlos症候群合併妊娠の周産期管理 : 症例報告と文献的レビュー

    54　(11)　1562-1565　2024/11/10

    Publisher:

    DOI： 10.24479/peri.0000001795 　

    ISSN： 0386-9881

  72. Early prediction of hypertensive disorders of pregnancy toward preventive early intervention. International-journal

    Satoshi Mizuno, Satoshi Nagaie, Junichi Sugawara, Gen Tamiya, Taku Obara, Mami Ishikuro, Shinichi Kuriyama, Nobuo Yaegashi, Hiroshi Tanaka, Masayuki Yamamoto, Soichi Ogishima

    AJOG global reports　4　(4)　100383-100383　2024/11

    DOI： 10.1016/j.xagr.2024.100383 　

    More details Close

    BACKGROUND: Various disease prediction models have been developed, capitalizing on the wide use of electronic health records, but environmental factors that are important in the development of noncommunicable diseases are rarely included in the prediction models. Hypertensive disorders of pregnancy are leading causes of maternal morbidity and mortality and are known to cause several serious complications later in life. OBJECTIVE: This study aims to develop early hypertensive disorders of pregnancy prediction models using comprehensive environmental factors based on self-report questionnaires in early pregnancy. STUDY DESIGN: We developed machine learning and artificial intelligence models for the early prediction of hypertensive disorders of pregnancy using early pregnancy data from approximately 23,000 pregnancies in the Tohoku Medical Megabank Birth and Three Generation Cohort Study. We clarified the important features for prediction based on regression coefficients or Gini coefficients of the interpretable artificial intelligence models (i.e., logistic regression, random forest and XGBoost models) among our developed models. RESULTS: The performance of the early hypertensive disorders of pregnancy prediction models reached an area under the receiver operating characteristic curve of 0.93, demonstrating that the early hypertensive disorders of pregnancy prediction models developed in this study retain sufficient performance in hypertensive disorders of pregnancy prediction. Among the early prediction models, the best performing model was based on self-reported questionnaire data in early pregnancy (mean of 20.2 gestational weeks at filling) which consist of comprehensive lifestyles. The interpretation of the models reveals that both eating habits were dominantly important for prediction. CONCLUSION: We have developed high-performance models for early hypertensive disorders of pregnancy prediction using large-scale cohort data from the Tohoku Medical Megabank project. Our study clearly revealed that the use of comprehensive lifestyles from self-report questionnaires led us to predict hypertensive disorders of pregnancy risk at the early stages of pregnancy, which will aid early intervention to reduce the risk of hypertensive disorders of pregnancy.

  73. Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Chikana Kawaguchi, Maki Ozawa, Takanori Hidaka, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Masatsugu Orui, Taku Obara, Yumiko Ito, Takashi Kakinuma, Kazuhiro Kudoh, Hiroaki Ozawa, Satoshi Nakagawa, Masato Mizuashi, Ryoko Omori, Masatoshi Deguchi, Yumi Kanbayashi, Masayuki Asano, Toshiya Takahashi, Muneo Tanita, Masahiro Hara, Kenshi Yamasaki, Takayoshi Tadaki, Hiromi Suzuki, Katsuko Kikuchi, Kenichiro Tsuchiyama, Takenobu Ohashi, Shu Sasai, Motoko Honda, Taku Fujimura, Sadanori Furudate, Yoshiko Kagimoto, Maki Kawamura, Nobuko Tabata, Rika Chikama, Hiromi Komatsu, Yota Sato, Kayo Tanita, Yutaka Kimura, Shino Yusa, Hitoshi Terui, Hisayuki Tono, Yusuke Muto, Shinichi Kuriyama, Masayuki Yamamoto, Setsuya Aiba

    Allergology international : official journal of the Japanese Society of Allergology　2024/10/18

    DOI： 10.1016/j.alit.2024.09.008 　

    More details Close

    BACKGROUND: Precise skin phenotypic data are indispensable in accurately diagnosing atopic dermatitis (AD). Therefore, this study examined the interobserver concordance for AD and non-AD diagnoses between two dermatologists. AD prevalence determined by the self-reported physician diagnoses and the diagnoses determined from the United Kingdom (UK) diagnostic criteria were compared with the diagnoses made by the two dermatologists, using data from a skin health survey. METHODS: This study included 1,638 children that participated in the skin health survey, which was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. AD was assessed using dermatologist assessments, self-reported physician diagnoses, and the UK diagnostic criteria. The concordance for diagnoses was evaluated using kappa. The sensitivity and specificity of the self-reported physician diagnoses and the UK diagnostic criteria were calculated by comparing them with the two dermatologists' diagnoses. RESULTS: Among the 1,638 children, 393 (24.0 %), 194 (11.9 %), and 597 (37.2 %) were diagnosed with AD by the two dermatologists, physicians, and the UK diagnostic criteria, respectively. The kappa (95 % CI) of the interobserver concordance for AD or non-AD diagnoses between the two dermatologists was 0.78 (0.75-0.81). The sensitivity and specificity of the self-reported physician diagnoses were 26.7 % and 94.1 %, respectively. The sensitivity and specificity of the UK diagnostic criteria were 85.0 % and 82.4 %, respectively. CONCLUSIONS: Interobserver concordance for AD or non-AD diagnoses between the two dermatologists was substantial. Self-reported physician diagnoses exhibited low sensitivity that potentially indicated underdiagnosis of AD, whereas the UK diagnostic criteria might overdiagnose AD.

  74. Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Mami Ishikuro, Taku Obara, Mayu Hasegawa, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Noriyuki Iwama, Masahiro Kikuya, Junichi Sugawara, Tatsuhiko Azegami, Takashin Nakayama, Asako Mito, Naoko Arata, Hirohito Metoki, Takeshi Kanda, Shinichi Kuriyama

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/10/11

    DOI： 10.1038/s41440-024-01936-9 　

    More details Close

    Hypertensive disorders of pregnancy can cause hypertension in the future. Understanding how the blood pressure values of women with and without hypertensive disorders of pregnancy differ will facilitate follow-up blood pressure monitoring in clinical settings. This study investigated the association between hypertensive disorders of pregnancy and subsequent high blood pressure and hypertension. This study used Japanese data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Follow-up systolic and diastolic blood pressures in normotensive women during pregnancy and those with hypertensive disorders of pregnancy were estimated using analysis of covariance adjusted for women with low birthweight, history of gestational diabetes mellitus, age, body mass index, pulse rate, smoking and drinking at the follow-up assessment, paternal hypertension history, and maternal hypertension or hypertensive disorders of pregnancy history. Finally, we performed a multiple logistic regression analysis. In total, 7343 women were included in the analysis. Women with a history of hypertensive disorders of pregnancy had higher blood pressure approximately three years postpartum compared with normotensive women. Hypertensive disorders of pregnancy in the most recent pregnancy in different subgroups, such as nulliparous women, multiparous women without a history of hypertensive disorders of pregnancy, and multiparous women with a history of hypertensive disorders of pregnancy, were associated with an increased risk of subsequent hypertension. Women's birthweight was also weakly associated with hypertension. Even one experience of hypertensive disorders of pregnancy may contribute to elevated blood pressure and hypertension approximately three years postpartum. In addition, women's birthweights may have a weak relationship with increasing blood pressure.

  75. Identification of risk loci for postpartum depression in a genome-wide association study. International-journal

    Xue Li, Nagahide Takahashi, Akira Narita, Yukako Nakamura, Mika Sakurai-Yageta, Keiko Murakami, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Fumihiko Ueno, Hirohito Metoki, Hisashi Ohseto, Ippei Takahashi, Tomohiro Nakamura, Noriko Warita, Tomoka Shoji, Zhiqian Yu, Chiaki Ono, Natsuko Kobayashi, Saya Kikuchi, Tasuku Matsuki, Fuji Nagami, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Norio Ozaki, Gen Tamiya, Shinichi Kuriyama, Hiroaki Tomita

    Psychiatry and clinical neurosciences　2024/09/17

    DOI： 10.1111/pcn.13731 　

    More details Close

    AIM: Genome-wide association studies (GWAS) of postpartum depression (PPD) based on accumulated cohorts with multiple ethnic backgrounds have failed to identify significantly associated loci. Herein, we conducted a GWAS of Japanese perinatal women along with detailed confounding information to uncover PPD-associated loci. METHODS: The first and second cohorts (n = 9260 and n = 8582 perinatal women enrolled in the Tohoku Medical Megabank Project) and the third cohort (n = 997), recruited at Nagoya University, underwent genotyping. Of them, 1421, 1264, and 225 were classified as PPD based on the Edinburgh Postnatal Depression Scale 1 month after delivery. The most influential confounding factors of genetic liability to PPD were selected, and logistic regression analyses were performed to evaluate genetic associations with PPD after adjusting for confounders. RESULTS: A meta-analysis of GWAS results from the three cohorts identified significant associations between PPD and the following loci (P < 5 × 10-8) by integrating the number of deliveries and the number of family members living together as the most influential confounders: rs377546683 at DAB1, rs11940752 near UGT8, rs141172317, rs117928019, rs76631412, rs118131805 at DOCK2, rs188907279 near ZNF572, rs504378, rs690150, rs491868, rs689917, rs474978, rs690118, rs690253 near DIRAS2, rs1435984417 at ZNF618, rs57705782 near PTPRM, and rs185293917 near PDGFB. Pathway analyses indicated that SNPs suggestively associated with PPD were mostly over-represented in categories including long-term depression, GnRH signaling, glutamatergic synapse, oxytocin signaling, and Rap1 signaling. CONCLUSION: The current GWAS study identified eight loci significantly associated with PPD, which may clarify the genetic structure underlying its pathogenesis.

  76. Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricaemia in a Japanese Population

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Biobank Japan Project; Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Rheumatology　2024/09/13

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/rheumatology/keae492 　

    ISSN： 1462-0324

    eISSN： 1462-0332

    More details Close

    Abstract Objective To investigate the inter-relationships among genetic risk, healthy lifestyle adherence, and hyperuricaemia susceptibility. Methods This prospective cohort study was conducted with 7,241 hyperuricaemia-free individuals aged ≥ 20 years from the Tohoku Medical Megabank Community-based cohort study. A comprehensive lifestyle score included body mass index, smoking, drinking, and physical activity, and a polygenic risk score (PRS) was constructed based on uric acid loci from a previous genome-wide association study meta-analysis. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and hyperuricaemia incidence and calculate the area under the receiver operating characteristic curve (AUROC). Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dl or a self-reported history of hyperuricaemia. Results Of the 7,241 adults (80.7% females; mean [SD] age: 57.7 [12.6] years), 217 (3.0%) developed hyperuricaemia during 3.5 years of follow-up. Genetic risk correlated with hyperuricaemia development (P for interaction = 0.287), and lifestyle risks were independently associated. Those with a high genetic risk and poor lifestyle had the highest risk (odds ratio: 5.34; 95% confidence interval [CI]: 2.61–12.10). Although not statistically significant, incorporating the PRS in the model with lifestyle information improved predictive ability (AUROC = 0.771, 95% CI: 0.736–0.806 for lifestyle; AUROC = 0.785, 95% CI: 0.751–0.819 for lifestyle and PRS; p = 0.07). Conclusion : A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk. Genetic risk may complement lifestyle factors in identifying individuals at a heightened hyperuricaemia risk.

  77. Association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. International-journal

    Tomofumi Ishikawa, Takamasa Sakai, Noriyuki Iwama, Ryo Obara, Kei Morishita, Motohiko Adomi, Aoi Noda, Mami Ishikuro, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, Masatoshi Saito, Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

    Acta psychiatrica Scandinavica　2024/09/05

    DOI： 10.1111/acps.13755 　

    More details Close

    OBJECTIVE: To evaluate the association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. MATERIAL AND METHODS: This nested case-control study used a large Japanese administrative database. Pregnancy onset and outcomes were estimated using previously reported algorithms, classifying cases as women becoming pregnant between 2013 and 2022 and ending in a miscarriage. Controls were randomly selected from the entire pregnancy cohort by risk-set sampling with replacement and were individually matched to the cases (3:1). The association between exposure to atypical antipsychotics and risk of miscarriage was assessed using conditional logistic regression adjusted for confounders. The association between benzodiazepine exposure and the risk of miscarriage was assessed as a positive control. RESULTS: In the cohort, 44,118 patients were matched with 132,317 controls. The mean ages (standard deviations) of the case and control groups were 33.3 (5.7) and 33.2 (5.5) years, respectively. The prevalence of atypical antipsychotics was 0.5% in both groups. Aripiprazole is an individual antipsychotic with the highest prescription prevalence. The adjusted odds ratios (aOR) for miscarriage were 0.966 (95% confidence interval [CI], 0.796-1.173) for atypical antipsychotics and 0.998 (0.784-1.269) for aripiprazole. A higher aOR (1.431, 95% CI 1.303-1.573) suggested an association with benzodiazepines. A sensitivity analysis that limited the population to women diagnosed with schizophrenia alone did not suggest an association between atypical antipsychotics and the risk of miscarriage. CONCLUSIONS: The results of this study do not suggest an association between exposure to atypical antipsychotics during pregnancy and the risk of miscarriage.

  78. Birth Weight and Labor Market Outcomes: Findings From Tohoku Medical Megabank Data. International-journal

    Midori Matsushima, Taku Obara, Mami Ishikuro, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama

    Public health challenges　3　(3)　e221　2024/09

    DOI： 10.1002/puh2.221 　

    More details Close

    BACKGROUND: Epidemiological and economic literature has revealed that low birth weight (LBW) is related to poor health conditions and a broader range of negative socio-economic outcomes, including academic achievement, income levels, and working status. However, Japanese evidence for labor outcomes is particularly lacking, as is the question of whether the impact of LBW on adulthood worsens when disasters occur. We aimed to reveal the impact on LBW on labor outcomes during the disaster recovery phase. METHODS: We used a cross-sectional data set of 4156 national health insurance holders, males aged 40-60 years, from the Miyagi and Iwate prefectures during the earthquake recovery phase. Employing a multinomial probit and logistic model, we estimated the impact of LBW on the employment status, changes in income, and the propensity to face a decline in income with a job change. RESULTS: The very low birth weights (VLBWs) have a disadvantage in all labor market outcomes. Compared to the non-LBWs, the VLBWs were 15.2% less likely to be full-time/self-employed and 17.1% more likely to be contingent/temporary/part-time workers. Moreover, 32.9% are more likely to face a decline in income and approximately 3.7 times more likely to change jobs leading to income decline. The LBWs were likely to face a decline in income by 8.6% and 4.6%, respectively, but no other significant effects were found on other outcomes. CONCLUSIONS: The effects were apparent for the VLBW, but not so much for the LBW. The effects became larger during the disaster recovery phase, even though the regional economies were boosted.

  79. Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Ippei Takahashi, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Ryo Obara, Aoi Noda, Minoru Ohsawa, Tomofumi Ishikawa, Nariyasu Mano, Hidekazu Nishigori, Fumihiko Ueno, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Shinichi Kuriyama

    PCN reports : psychiatry and clinical neurosciences　3　(3)　e226　2024/09

    DOI： 10.1002/pcn5.226 　

    More details Close

    AIM: To examine the association of the combination of taking neuropsychiatric medications from the onset of pregnancy to mid-pregnancy and maternal psychological distress at mid-pregnancy, with children's behavioral problems. METHODS: Neuropsychiatric medication use from the onset of pregnancy to mid-pregnancy was defined by the self-reported name of the neuropsychiatric medication in the questionnaire in early and mid-pregnancy. Maternal psychological distress was defined by the Kessler Psychological Distress Scale (K6) ≥13 on the questionnaire in mid-pregnancy. We classified the participants into four categories based on the combination of taking neuropsychiatric medications and psychological distress: "None," "Medications only," "K6 ≥ 13 only," and "Both." Children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) at 2 years of age. The clinical ranges of the internalizing and externalizing scales of the CBCL were defined as behavioral problems. We conducted a multivariable logistic regression analysis to examine the associations between the four categories of maternal exposure and children's behavioral problems. RESULTS: Compared with the "None" category (n = 9873), the "K6 ≥ 13 only" category (n = 308) was statistically significantly associated with internalizing and externalizing problems. In contrast, the "Medications only" (n = 93) and "Both" (n = 22) categories were not statistically significantly associated with internalizing and externalizing problems, although the point estimates of the odds ratio in the "Both" category were relatively high (1.58 for the internalizing problem and 2.50 for the externalizing problem). CONCLUSION: The category of mothers taking neuropsychiatric medications and having no psychological distress during pregnancy was not associated with children's behavioral problems in the present population.

  80. Genome-wide association study based on clustering by obesity-related variables uncovers a genetic architecture of obesity in the Japanese and the UK populations. International-journal

    Ippei Takahashi, Hisashi Ohseto, Fumihiko Ueno, Tomomi Oonuma, Akira Narita, Taku Obara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Atsushi Hozawa, Junichi Sugawara, Gen Tamiya, Shinichi Kuriyama

    Heliyon　10　(16)　e36023　2024/08/30

    DOI： 10.1016/j.heliyon.2024.e36023 　

    More details Close

    Whether all obesity-related variants contribute to the onset of obesity or one or a few variants cause obesity in genetically heterogeneous populations remains obscure. Here, we investigated the genetic architecture of obesity by clustering the Japanese and British populations with obesity using obesity-related factors. In Step-1, we conducted a genome-wide association study (GWAS) with body mass index (BMI) as the outcome for eligible participants. In Step-2, we assigned participants with obesity (BMI ≥25 kg/m2) to five clusters based on obesity-related factors. Subsequently, participants from each cluster and those with a BMI <25 kg/m2 were combined. A GWAS was conducted for each cluster. Several previously identified obesity-related genes were verified in Step-1. Of the genes detected in Step-1, unique obesity-related genes were detected separately for each cluster in Step-2. Our novel findings suggest that a smaller sample size with increased homogeneity may provide insights into the genetic architecture of obesity.

  81. Child-parent associations of hematocrit in trios of Japanese adulthood confirmed by the random family method: The TMM BirThree Cohort Study. International-journal

    Takuma Usuzaki, Mami Ishikuro, Masahiro Kikuya, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

    Scientific reports　14　(1)　19047-19047　2024/08/16

    DOI： 10.1038/s41598-024-69752-2 　

    More details Close

    To examine child-parent associations of HCT among Japanese adults and their parents. Factors associated with hematocrit (HCT) were analyzed in 3,574 sons and 7,203 daughters using Pearson's correlation coefficient and Student's t-test. Multiple linear regression analysis, adjusted by the factors identified by univariate analyses and by living with parents, was performed on 242 son-parent trios and 587 daughter-parent trios. When a child-parent association was observed in the multiple linear regression analysis, it was validated using the random family method (RFM). In univariate analyses, the son's HCT was associated with age (correlation coefficient = -0.072), white blood cell (WBC) (0.19), alanine aminotransferase (ALT) (0.20), triglyceride (0.11), and estimated glomerular filtration rate (eGFR) (- 0.087). The daughter's HCT was associated with WBC (0.014), ALT (0.18), and eGFR (- 0.17). In multiple linear regression analysis, the son's HCT was associated with the son's WBC (coefficient = 3.48 × 10-4), the son's eGFR (0.031), the father's HCT (0.11), and the mother's HCT (0.17). RFM confirmed the association between the son's and father's HCT (p = 0.0070) and between the son's and mother's HCT (p = 0.0011). The daughter's HCT was associated with WBC (2.6 × 10-4), ALT (0.037), and the mother's HCT (0.14). RFM confirmed the association between the daughter's and mother's HCT (p = 0.00043). Child-parent association of HCT was confirmed between son-father, son-mother, and daughter-mother relationships, and differed depending on the sex of the child and the parents.

  82. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. International-journal

    Hiromi Himuro, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Naho Tsuchiya, Takumi Hirata, Masatsugu Orui, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Akira Uruno, Nobuo Fuse, Satoshi Nagaie, Soichi Ogishima, Mami Ishikuro, Taku Obara, Yoko Izumi, Masatoshi Saito, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/08/08

    DOI： 10.1038/s41440-024-01827-z 　

    More details Close

    This study aimed to investigate the association of combination of birth weight and current body mass index (BMI) with the risk of hypertension in adulthood. This cross-sectional study used data from the Tohoku Medical Megabank Community-based Cohort Study conducted in Japan. A total of 10,688 subjects aged ≥20 years were eligible. We calculated the least square (LS) means of systolic blood pressure (SBP) and trend tests were performed to evaluate the linear relationships between birth weight categories and SBP. We also used a multivariate logistic regression analysis to assess the risk of hypertension associated with the combination of birth weight and current BMI. There was a statistically inverse association between birth weight and SBP in the 20-64 age group, but no significant association in the ≥65 age group. Low birth weight (LBW) with normal BMI group had a higher risk of hypertension than the normal or high birth weight groups with normal BMI. Furthermore, the group with LBW and BMI ≥25.0 kg/m2 was the highest risk for hypertension (adjusted odds ratio: 2.73; 95% CI, 2.04-3.65) compared to the reference group (birth weight 2500-3499 g and BMI 18.5-24.9 kg/m2). There was a significant association between LBW and subsequent risk of hypertension. In addition, participants with lower birth weights had a higher risk of hypertension than those with higher birth weights. However, even in participants with a lower birth weight, the risk of hypertension could be reduced when they maintained an optimal BMI.

  83. Trends in prescribing nifedipine and amlodipine to pregnant women after related contraindications were lifted in Japan

    Daisuke Kikuchi, Taku Obara, Hiroyuki Suzuki, Taisuke Konno, Kouji Okada, Hitoshi Nakamura, Yuriko Murai

    Hypertension Research　2024/08/02

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-024-01821-5 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  84. Comparison of renal prognosis between dipeptidyl peptidase-4 inhibitor users and non-users. International-journal

    Hideaki Hashimoto, Michihiro Satoh, Shingo Nakayama, Maya Toyama, Takahisa Murakami, Taku Obara, Naoki Nakaya, Takefumi Mori, Atushi Hozawa, Hirohito Metoki

    Diabetes, obesity & metabolism　2024/07/31

    DOI： 10.1111/dom.15800 　

    More details Close

    AIM: To evaluate the renal prognosis of dipeptidyl peptidase-4 inhibitor (DPP-4i) users and non-users using real-world Asian data. METHODS: Using databases from DeSC Healthcare, Inc., patients aged 30 years or older who used antidiabetic drugs from 2014 to 2021 were identified. Propensity score matching analyses were used to compare renal prognosis between DPP-4i users and non-users. The primary outcomes were estimated glomerular filtration rate (eGFR) decline and end-stage kidney disease (ESKD) development in the eGFR of 45 mL/min/1.73m2 or higher and eGFR of less than 45 mL/min/1.73m2 groups, respectively. RESULTS: In total, 65 375 and 9866 patients were identified in the eGFR of 45 mL/min/1.73m2 or higher and eGFR of less than 45 mL/min/1.73m2 groups, respectively. In the eGFR of 45 mL/min/1.73m2 or higher group, propensity score matching created 16 002 pairs. A significant difference was observed in the primary outcome of eGFR decline between DPP-4i users and non-users at 2 years (-2.31 vs. -2.56 mL/min/1.73m2: difference, 0.25 mL/min/1.73m2; 95% confidence interval [CI], 0.06-0.44) and 3 years (-2.75 vs. -3.41 mL/min/1.73m2: difference, 0.66 mL/min/1.73m2; 95% CI, 0.39-0.93). In the eGFR less than 45 mL/min/1.73m2 group, propensity score matching created 2086 pairs. After a mean of 2.2 years of observation, ESKD development was 1.15% and 2.30% in users and non-users, respectively, and Kaplan-Meier analysis revealed a significant difference (log rank P = .005). CONCLUSIONS: This retrospective real-world study revealed that patients using DPP-4is had a better renal prognosis than those not using DPP-4is.

  85. Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study.

    Seiya Izumi, Noriyuki Iwama, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Michihiro Satoh, Takahisa Murakami, Masatoshi Saito, Takayoshi Ohkubo, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

    Endocrine journal　2024/07/26

    DOI： 10.1507/endocrj.EJ23-0568 　

    More details Close

    This study aimed to evaluate the associations of fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) levels at <24 weeks of gestation with hypertensive disorders of pregnancy (HDP) and compare the strengths of the associations of HDP with FPG and HbA1c levels. Totally, 1,178 participants were included in this prospective cohort study. HDP, FPG, HbA1c, and potential confounding factors were included in multiple logistic regression models. The number of HDP cases was 136 (11.5%). When FPG and HbA1c were included in the model separately, quartile 4 (Q4) of FPG (87-125 mg/dL) and HbA1c (5.2-6.3% [33-45 mmol/mol]) levels had higher odds of HDP than quartile 1. The odds ratios (ORs) were 1.334 (95% confidence interval [CI]: 1.002-1.775) for Q4 of FPG and 1.405 (95% CI: 1.051-1.878) for Q4 of HbA1c. When the participants were divided into two categories based on the cut-off value with the maximum Youden Index of FPG or HbA1c, the ORs for high FPG (≥84 mg/dL) or high HbA1c (≥5.2% [33 mmol/mol]) were 1.223 (95% CI: 1.000-1.496) and 1.392 (95% CI: 1.122-1.728), respectively. When both FPG and HbA1c were included in the model simultaneously, the statistical significance of Q4 of FPG disappeared, whereas that of HbA1c remained. In two-category models, the same results were obtained. High FPG and HbA1c levels at <24 weeks of gestation were risk factors for HDP in pregnant Japanese women. In addition, high HbA1c levels were more strongly associated with HDP than high FPG levels.

  86. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Tomohiro Nakamura, Hirohito Metoki, Soichi Ogishima, Yoko Izumi, Naoki Nakaya, Atsushi Hozawa, Tadashi Ishii, Fuji Nagami, Masayuki Yamamoto, Shinichi Kuriyama

    JMA journal　7　(3)　353-363　2024/07/16

    DOI： 10.31662/jmaj.2024-0043 　

    More details Close

    INTRODUCTION: To examine the interaction between lifestyle habits and the COVID-19 vaccinations for preventing SARS-CoV-2 infection, we analyzed 11,016 adult participants registered in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. METHODS: Lifestyle variables, including regular exercise, smoking and drinking habits, sleep status, body mass index, and daily breakfast consumption, were assessed from 2014 to 2019 using baseline questionnaires. Information on SARS-CoV-2 infection and the COVID-19 vaccination were also collected from March 2020 to May 2023. The study period was divided into two in the postvaccination phase: the first period (the beginning of the vaccination program) and the second period (the fourth shot onward). RESULTS: In the Cox proportional-hazards model analysis, the five-time vaccinations group showed a significantly lower risk of SARS-CoV-2 infection adjusted age, sex, underlying health condition, and lifestyle variables (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.76-0.86). Logistic regression analysis revealed that a higher number of vaccinations was significantly associated with a low risk of SARS-CoV-2 infection regardless of lifestyle habits (three times in the first period: odds ratio [OR] 0.19, 95% CI 0.15-0.24; five times in the second period: OR 0.07, 95% CI 0.05-0.11 vs. none). Regarding lifestyle habits, the risk reduction in those who had sleep satisfaction (OR 0.12, 95% CI 0.08-0.18) was slightly larger than in those who had sleep dissatisfaction (OR 0.23, 95% CI 0.17-0.32) in the group with the highest number of vaccinations in the first period; however, this interaction was hardly confirmed in the second period when the number of infected cases significantly increased. CONCLUSIONS: Our findings indicated that a higher number of COVID-19 vaccinations was associated with reduced risk of SARS-CoV-2 infection; otherwise, we may need to understand the advantages and limitations of a healthy lifestyle for preventing infection depending on the situation with vaccinations and infection spreading.

  87. Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. International-journal

    Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/07/10

    DOI： 10.1038/s41440-024-01790-9 　

    More details Close

    Depression is comorbid with somatic diseases; however, the relationship between depressive symptoms and hypertension (HT), a risk factor for cardiovascular events, remains unclear. Home blood pressure (BP) is more reproducible and accurately predictive of cardiovascular diseases than office BP. Therefore, we focused on home BP and investigated whether depressive symptoms contributed to the future onset of home HT. This prospective cohort study used data from the Tohoku Medical Megabank Community-Cohort Study (conducted in the Miyagi Prefecture, Japan) and included participants with home normotension (systolic blood pressure (SBP) < 135 mmHg and diastolic blood pressure (DBP) < 85 mmHg). Depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale-Japanese version at the baseline survey. In the secondary survey, approximately 4 years later, the onset of home HT was evaluated (SBP ≥ 135 mmHg or DBP ≥ 85 mmHg) and was compared in participants with and without depressive symptoms. Of the 3 082 (mean age: 54.2 years; females: 80.9%) participants, 729 (23.7%) had depressive symptoms at the baseline survey. During the 3.5-year follow-up, 124 (17.0%) and 388 (16.5%) participants with and without depressive symptoms, respectively, developed home HT. Multivariable adjusted odds ratios were 1.37 (95% confidence interval (CI): 1.02-1.84), 1.18 (95% CI: 0.86-1.61), and 1.66 (95% CI: 1.17-2.36) for home, morning, and evening HT, respectively. This relationship was consistent in the subgroup analyses according to age, sex, BP pattern, and drinking habit. Depressive symptoms increased the risk of new-onset home HT, particularly evening HT, among individuals with home normotension. This prospective cohort study revealed that depressive symptoms are risk factors for new-onset home hypertension, particularly evening hypertension among individuals with home normotension. Assessing home blood pressure in individuals with depressive symptoms is important for the prevention of hypertension and concomitant cardiovascular diseases.

  88. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. International-journal

    Miyuki Sakurai, Ikuko N Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, Kazuki Kumada, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

    Scientific reports　14　(1)　15681-15681　2024/07/08

    DOI： 10.1038/s41598-024-66180-0 　

    More details Close

    Understanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55-59 to 60-64 years being a period of significant metabolic change, particularly in men, and from 45-49 to 50-54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.

  89. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. International-journal

    Masato Takase, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Akira Narita, Hirohito Metoki, Michihiro Satoh, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/06/24

    DOI： 10.1038/s41440-024-01705-8 　

    More details Close

    No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (n = 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (n = 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34-2.80) and 2.15 (1.60-2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.

  90. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Journal of atherosclerosis and thrombosis　2024/06/22

    DOI： 10.5551/jat.64906 　

    More details Close

    AIM: This study examined the relationship between genetic risk, healthy lifestyle, and risk of developing diabetes. METHODS: This prospective cohort study included 11,014 diabetes-free individuals ≥ 20 years old from the Tohoku Medical Megabank Community-based cohort study. Lifestyle scores, including the body mass index, smoking, physical activity, and gamma-glutamyl transferase (marker of alcohol consumption), were assigned, and participants were categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score (PRS) was constructed based on the type 2 diabetes loci from the BioBank Japan study. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and diabetes incidence and to calculate the area under the receiver operating characteristic curve (AUROC). RESULT: Of the 11,014 adults included (67.8% women; mean age [standard deviation], 59.1 [11.3] years old), 297 (2.7%) developed diabetes during a mean 4.3 (0.8) years of follow-up. Genetic and lifestyle score is independently associated with the development of diabetes. Compared with the low genetic risk and ideal lifestyle groups, the odds ratio was 3.31 for the low genetic risk and poor lifestyle group. When the PRS was integrated into a model including the lifestyle and family history, the AUROC significantly improved to 0.719 (95% confidence interval [95% CI]: 0.692-0.747) compared to a model including only the lifestyle and family history (0.703 [95% CI, 0.674-0.732]). CONCLUSION: Our findings indicate that adherence to a healthy lifestyle is important for preventing diabetes, regardless of genetic risk. In addition, genetic risk might provide information beyond lifestyle and family history to stratify individuals at high risk of developing diabetes.

  91. リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

    橋本 英明, 佐藤 倫広, 村上 任尚, 遠山 真弥, 中山 晋吾, 小原 拓, 中谷 直樹, 森 建文, 寳澤 篤

    日本腎臓学会誌　66　(4)　616-616　2024/06

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  92. リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

    橋本 英明, 佐藤 倫広, 村上 任尚, 遠山 真弥, 中山 晋吾, 小原 拓, 中谷 直樹, 森 建文, 寳澤 篤

    日本腎臓学会誌　66　(4)　616-616　2024/06

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  93. Maternal birth weight is an indicator of preterm delivery: The Japan environment and children's study

    Rie Kudo, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

    Journal of Developmental Origins of Health and Disease　15　2024/05/22

    DOI： 10.1017/S2040174424000126 　

    ISSN： 2040-1744

    eISSN： 2040-1752

  94. Associations between housing and psychological damage by earthquake and modifiable risk factors for dementia in general older adults: Tohoku Medical Megabank community-based cohort study.

    Ippei Chiba, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Tomohiro Nakamura, Satoshi Nagaie, Nobuo Fuse, Taku Obara, Yuka Kotozaki, Kozo Tanno, Shinichi Kuriyama, Atsushi Hozawa

    Geriatrics & gerontology international　2024/05/03

    DOI： 10.1111/ggi.14867 　

    More details Close

    AIM: To evaluate the association between housing and psychological damage caused by the Great East Japan Earthquake (GEJE) and modifiable risk factors (MRFs) of dementia for general population of older adults. METHODS: This cross-sectional study enrolled 29 039 community-dwelling older adults (mean age 69.1 ± 2.9 years, 55.5% women). We evaluated disaster-related damage (by complete or not complete housing damage) and psychological damage (by post-traumatic stress reaction [PTSR]) after the GEJE using a self-report questionnaire. MRFs encompassed the presence of depression, social isolation, physical inactivity, smoking, and diabetes. We examined the association between disaster-related damage and MRFs using ordinary least squares and modified Poisson regression models adjusted for sociodemographic and health status variables. RESULTS: Complete housing damage and PTSR were identified in 2704 (10.0%) and 855 (3.2%) individuals, respectively. The number of MRFs was significantly larger for the individuals with complete housing damage (β = 0.23; 95% confidence interval [CI]: 0.19-0.27) and PTSR (β = 0.60; 95% CI: 0.53-0.67). Prevalence ratios (PRs) for depression and physical inactivity were higher in individuals with complete housing damage. The PRs for all domains of the MRFs were significantly higher in individuals with PTSR. CONCLUSIONS: Housing and psychological damage caused by the GEJE were associated with an increased risk factor of dementia. To attenuate the risk of dementia, especially among older victims who have experienced housing and psychological damage after a disaster, multidimensional support across various aspects of MRFs is required. Geriatr Gerontol Int 2024; ••: ••-••.

  95. 周産期医薬品情報の創出に関する薬剤疫学研究の実施可能性に関する研究

    小原 拓, 岡田 裕子, 菊池 大輔, 近藤 悠希, 酒井 隆全, 佐藤 泉美, 佐藤 ユリ, 土屋 雅美, 畠山 史朗

    日本医薬品情報学会総会・学術大会講演要旨集　26回　115-115　2024/05

    Publisher: (一社)日本医薬品情報学会

  96. The association between blood pressure control in women during pregnancy and adverse perinatal outcomes: the TMM BirThree Cohort Study. International-journal

    Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Masahiro Kikuya, Hirohito Metoki, Shinichi Kuriyama

    Hypertension research : official journal of the Japanese Society of Hypertension　47　(5)　1216-1222　2024/05

    DOI： 10.1038/s41440-023-01570-x 　

    More details Close

    Blood pressure (BP) control in pregnancy is essential to prevent adverse outcomes. However, BP levels for hypertension treatment are inconsistent among various guidelines. This study investigated the association between BP control and adverse perinatal outcomes. A total of 18,155 mother-offspring pairs were classified into four groups according to BP after 20 gestational weeks: normal BP (<140/90 mmHg without antihypertensive drugs), high BP (≥140/90 mmHg without antihypertensive drugs), controlled BP (<140/90 mmHg with antihypertensive drugs), and uncontrolled BP (≥140/90 mmHg with antihypertensive drugs). The prevalence of small for gestational age was 1,087/17,476 offspring in normal BP, 78/604 in high BP, 5/42 in controlled BP, and 7/33 in uncontrolled BP. Compared to normal BP, adjusted odds ratios (ORs) (95% confidence intervals (CIs)) were 1.76 (1.32-2.35) for high BP, 2.08 (0.79-5.50) for controlled BP, and 2.34 (0.94-5.85) for uncontrolled BP (multiple logistic regression analysis). Similarly, the adjusted ORs (95% CIs) were 1.80 (1.35-2.41), 3.42 (1.35-8.63), and 5.10 (1.93-13.45) for high, controlled, and uncontrolled BPs for low birth weight, respectively; 1.99 (1.48-2.68), 2.70 (1.12-6.50), and 6.53 (3.09-13.82) for high, controlled, and uncontrolled BPs for preterm birth, respectively; 1.64 (1.19-2.24), 2.17 (0.88-5.38), and 2.12 (0.80-5.65) for high, controlled, and uncontrolled BPs for admission to the Neonatal Intensive Care Unit or Growing Care Unit, respectively; and 1.17 (0.70-1.95), 2.23 (0.65-7.68), and 0.91 (0.20-4.16) for high, controlled, and uncontrolled BPs for 1-min Apgar score < 7, respectively. BP ≥ 140/90 mmHg might be taken care for preventing various adverse perinatal outcomes.

  97. Combined effects of blood pressure and glucose status on the risk of chronic kidney disease. International-journal

    Maya Toyama, Michihiro Satoh, Shingo Nakayama, Hideaki Hashimoto, Tomoko Muroya, Takahisa Murakami, Takuo Hirose, Taku Obara, Naoki Nakaya, Takefumi Mori, Takayoshi Ohkubo, Yutaka Imai, Atsushi Hozawa, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/04/26

    DOI： 10.1038/s41440-024-01683-x 　

    More details Close

    This study aimed to assess the combined effects of blood pressure (BP) and glucose status on chronic kidney disease (CKD) incidence in young and middle-aged adults. We examined data from 1,297,341 Japanese individuals aged <60 years (60.1% men; mean age 41.4 ± 9.3 years) with no history of CKD at baseline. The interval-censored Cox proportional hazards model with covariates was used. During a median follow-up period of 2.1 years, new onset CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2 and/or proteinuria) occurred in 80,187 participants. In participants without antihypertensive treatment (AHT), the adjusted hazard ratios (95% confidence interval) per 1-standard deviation, that is, 15 mmHg increase in systolic BP for CKD incidence, were 1.08 (1.07-1.09), 1.12 (1.10-1.13), and 1.15 (1.12-1.18) in normoglycemia, borderline glycemia, and diabetes groups, respectively. These ratios were significantly higher in the borderline glycemia and diabetes groups compared with those in the normoglycemia group (interaction p < 0.0001). The interaction between BP and borderline glycemia was evident when the outcome definition was restricted to proteinuria. In participants under AHT, systolic BP was most strongly associated with CKD risk in the diabetes group, although no significant interaction was observed. High BP and high glucose status may synergistically increase the incidence of CKD. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population. This large-scale longitudinal cohort study showed high BP and diabetes synergistically increased the risk of CKD in individuals without AHT. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population.

  98. Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Aoi Noda, Taku Obara, Matsuyuki Shirota, Fumihiko Ueno, Fumiko Matsuzaki, Rieko Hatanaka, Ryo Obara, Kei Morishita, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Shinichi Kuriyama

    European journal of clinical pharmacology　2024/04/17

    DOI： 10.1007/s00228-024-03685-7 　

    More details Close

    PURPOSE: To elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: Questionnaires were distributed to pregnant women participating in the TMM BirThree Cohort Study (from July 2013 to March 2017) around 12 weeks (early pregnancy) and 26 weeks (middle pregnancy). We analysed medication use over three periods: (1) 12 months prior to pregnancy diagnosis, (2) the period between pregnancy diagnosis and around week 12 of pregnancy, and (3) post around week 12 of pregnancy. RESULTS: In total, 19,297 women were included in the analysis. The proportion of pregnant women using medications was 49.0% prior to pregnancy diagnosis, 52.1% from diagnosis to week 12, and 58.4% post week 12 of pregnancy. The most frequently prescribed medications were loxoprofen sodium hydrate (5.5%) prior to pregnancy diagnosis, magnesium oxide (5.9%) from diagnosis to week 12, and ritodrine hydrochloride (10.5%) post week 12 of pregnancy. The number of women who used suspected teratogenic medications during early pregnancy was 96 prior to pregnancy diagnosis, 48 from diagnosis to week 12, and 54 post week 12 of pregnancy. CONCLUSION: We found that ~ 50% of the pregnant women used medications before and during pregnancy and some took potential teratogenic medications during pregnancy. In birth genomic cohort study, it is expected that investigations into the safety and effectiveness of medications used during pregnancy will advance.

  99. フェブキソスタット内服者とトピロキソスタット内服者の腎予後の比較 健診・レセプトデータ分析

    中山 晋吾, 佐藤 倫広, 遠山 真弥, 橋本 英明, 村上 任尚, 廣瀬 卓男, 小原 拓, 森 建文, 目時 弘仁

    日本循環器病予防学会誌　59　(2)　135-135　2024/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  100. 治療有無別の血圧およびコレステロールと冠動脈疾患リスクとの関連 大規模健診・レセプトデータに基づく解析

    佐藤 倫広, 村上 任尚, 橋本 英明, 遠山 真弥, 中山 晋吾, 小原 拓, 大久保 孝義, 目時 弘仁

    日本循環器病予防学会誌　59　(2)　134-134　2024/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  101. Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study. International-journal

    Yudai Yonezawa, Ippei Takahashi, Hisashi Ohseto, Fumihiko Ueno, Tomomi Onuma, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

    BMC pregnancy and childbirth　24　(1)　209-209　2024/03/20

    DOI： 10.1186/s12884-024-06376-4 　

    More details Close

    BACKGROUND: Nausea and vomiting during pregnancy (NVP) and hyperemesis gravidarum (HG), common conditions affecting most pregnant women, are highly heritable and associated with maternal and fetal morbidity. However, the pathologies underlying NVP and HG and their associated loci are scarce. METHODS: We performed genome-wide association studies (GWAS) of NVP in pregnant women (n = 23,040) who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan from July 2013 to March 2017. Participants were divided into discovery (n = 9,464) and replication (n = 10,051) stages based on the platform used for their genotyping. Loci that achieved the genome-wide significance level (p < 5.0 × 10- 8) in the discovery stage were selected for genotyping in the replication stage. A meta-analysis integrating the discovery and replication stage results (n = 19,515) was conducted. NVP-related variables were identified as categorical or continuous. RESULTS: GWAS analysis in the discovery phase revealed loci linked to NVP in two gene regions, 11q22.1 (rs77775955) and 19p13.11 (rs749451 and rs28568614). Loci in these two gene regions have also been shown to be associated with HG in a White European population, indicating the generalizability of the GWAS analyses conducted in this study. Of these, only rs749451 and rs28568614 at 19p13.11 reached the genome-wide suggestive level (p < 1.0 × 10- 5) in the replication stage; however, both loci were significant in the meta-analysis. CONCLUSIONS: NVP-related loci were identified in the Japanese population at 11q22.1 and 19p13.11, as reported in previous GWAS. This study contributes new evidence on the generalizability of previous GWAS on the association between genetic background and NVP.

  102. Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

    Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Natsuko Kobayashi, Saya Kikuchi, Xue Li, Aoi Noda, Keiko Murakami, Gen Tamiya, Junichi Sugawara, Hiroaki Tomita, Shinichi Kuriyama

    Depression and Anxiety　2024　1-13　2024/03/15

    Publisher: Wiley

    DOI： 10.1155/2024/6622666 　

    ISSN： 1091-4269

    eISSN： 1520-6394

    More details Close

    This study is aimed at revealing the risk factors, prognosis, influence on offspring, and genetic architecture of perinatal depression (PD) classified based on the depressive symptom trajectory. Pregnant women with no history of major depressive disorder (MDD) were recruited and followed up with their offspring from 1 to 5 years postpartum. Using four self-report questionnaires in the perinatal period, PD was classified into four subtypes: pregnancy, early postpartum, late postpartum, and chronic PD. Risk factors, depressive symptom trajectory from 1 to 5 years postpartum, and child behavior problems were compared among the four PD subtypes. Genome-wide association studies (GWASs) were conducted for each subtype. The relationships between the PD subtypes and polygenic risk scores (PRS) for MDD, a psychiatric disorder, and premenstrual syndrome (PMS), a hormonal disorder, were examined. Among 12,338 participants, 1,145 (9.3%) developed pregnancy PD, 856 (6.9%) developed early postpartum PD, 382 (3.1%) developed late postpartum PD, and 1,048 (8.5%) developed chronic PD. Depressive symptoms decreased to 61.0%–73.3% in the 5 years postpartum. The relationship between risk factors and PD varied based on the PD subtype. Additionally, chronic PD increased the risk of child behavior problems by 2- to 3-fold. The GWASs uncovered five significant variants in different loci depending on PD subtypes, suggesting a subtype-specific genetic architecture. The PRS for MDD was related to pregnancy, early postpartum, and chronic PD, while that for PMS was related to late postpartum PD. It was concluded that PD is heterogeneous depending on the depressive symptom trajectory. Thus, specific prevention and treatment strategies are needed.

  103. Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. International-journal

    Satoshi Mizuno, Maiko Wagata, Satoshi Nagaie, Mami Ishikuro, Taku Obara, Gen Tamiya, Shinichi Kuriyama, Hiroshi Tanaka, Nobuo Yaegashi, Masayuki Yamamoto, Junichi Sugawara, Soichi Ogishima

    Scientific reports　14　(1)　6292-6292　2024/03/15

    DOI： 10.1038/s41598-024-55914-9 　

    More details Close

    Recently, many phenotyping algorithms for high-throughput cohort identification have been developed. Prospective genome cohort studies are critical resources for precision medicine, but there are many hurdles in the precise cohort identification. Consequently, it is important to develop phenotyping algorithms for cohort data collection. Hypertensive disorders of pregnancy (HDP) is a leading cause of maternal morbidity and mortality. In this study, we developed, applied, and validated rule-based phenotyping algorithms of HDP. Two phenotyping algorithms, algorithms 1 and 2, were developed according to American and Japanese guidelines, and applied into 22,452 pregnant women in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank project. To precise cohort identification, we analyzed both structured data (e.g., laboratory and physiological tests) and unstructured clinical notes. The identified subtypes of HDP were validated against reference standards. Algorithms 1 and 2 identified 7.93% and 8.08% of the subjects as having HDP, respectively, along with their HDP subtypes. Our algorithms were high performing with high positive predictive values (0.96 and 0.90 for algorithms 1 and 2, respectively). Overcoming the hurdle of precise cohort identification from large-scale cohort data collection, we achieved both developed and implemented phenotyping algorithms, and precisely identified HDP patients and their subtypes from large-scale cohort data collection.

  104. Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Geng Chen, Mami Ishikuro, Hisashi Ohseto, Keiko Murakami, Aoi Noda, Genki Shinoda, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

    Acta obstetricia et gynecologica Scandinavica　2024/03/07

    DOI： 10.1111/aogs.14820 　

    More details Close

    INTRODUCTION: Developmental delay at an early age indicates the probability of continued problems after school age. Hypertensive disorders of pregnancy (HDP) are associated with developmental delays in offspring, with inconsistent outcomes. Neonatal outcomes vary according to HDP exposure and are relevant to development in later years. Here we aimed to clarify the relationship between HDP and developmental delay in offspring and whether neonatal outcomes mediate this association. MATERIAL AND METHODS: We used data from 5934 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study conducted in Japan between July 2013 and March 2017. The Ages and Stages Questionnaires, third edition, at 24 and 42 months of age, measured developmental delay in five areas. We performed multivariate quasi-Poisson regression and causal mediation analysis by neonatal outcomes. RESULTS: At 24 months of age, compared to offspring born from normotensive mothers, offspring born from HDP-affected mothers were more likely to experience developmental delay (risk ratio [RR] 1.29, 95% confidence interval [CI]: 1.09-1.52) in the areas of communication (RR 1.21, 95% CI: 1.00-1.45) and personal-social (RR 1.15, 95% CI: 1.03-1.28). This association was mediated by neonatal outcomes: preterm birth, neonatal asphyxia, NICU admission, and neonatal small head circumference. No association was observed between HDP and developmental delay at 42 months of age. CONCLUSIONS: Exposure to HDP during fetal life is associated with offspring developmental delay. This association is partly mediated by neonatal outcomes.

  105. Role of Genetic Risk in the Association Between Screen Time and Child Development. International-journal

    Ippei Takahashi, Taku Obara, Shinichi Kuriyama

    JAMA pediatrics　178　(3)　317-318　2024/03/01

    DOI： 10.1001/jamapediatrics.2023.6106 　

  106. 血圧コントロール不良に対する不十分な高血圧薬物治療による影響 リアルワールドデータに基づく解析 日本循環器病予防学会予防医学賞を受賞して

    佐藤 倫広, 室谷 智子, 村上 任尚, 小原 拓, 浅山 敬, 大久保 孝義, 今井 潤, 目時 弘仁

    日本循環器病予防学会誌　59　(1)　50-54　2024/03

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  107. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. International-journal

    Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Atsushi Shimizu, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/02/29

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-024-01582-1 　

    ISSN： 0916-9636

    eISSN： 1348-4214

    More details Close

    Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 men and 38,921 women aged ≥20 years). A model adjusted for age, body mass index, smoking status, drinking status, estimated daily salt intake, potassium excretion, (or urinary sodium-to-potassium ratio), gamma-glutamyl transferase, physical activity, education level, status of damage to homes during the Great East Japan Earthquake, and residential areas was used. The average age and systolic blood pressure were 62.5 (10.3) years for men and 59.6 (11.3) years for women, 128.9 (16.7) mmHg for men and 124.7 (17.5) mmHg for women, respectively. Body mass index estimated daily salt intake, urinary sodium-to-potassium ratio and gamma-glutamyl transferase levels were positively associated with systolic blood pressure. Compared with never-drinkers, current drinkers who consumed 23–45 g/day and ≥46.0 g/day had significantly increased systolic blood pressure. Conversely, current smokers (1-10 cigarettes/day and 11-20 cigarettes/day) were inversely associated with systolic blood pressure compared to never-smokers. Overall, systolic blood pressure was associated with gamma-glutamyl transferase and hypertension risk factors, including body mass index, alcohol consumption, estimated daily salt intake, urinary sodium-to-potassium ratio, and potassium excretion. Our findings support the notion that lifestyle modifications should be attempted to prevent hypertension.

  108. Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

    Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology　2024/02/24

    DOI： 10.2188/jea.JE20230241 　

    More details Close

    BACKGROUND: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. METHODS: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). RESULTS: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. CONCLUSIONS: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.

  109. Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

    Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

    Journal of diabetes investigation　2024/02/23

    DOI： 10.1111/jdi.14159 　

    More details Close

    AIMS: This study aimed to investigate the association of maternal birth weight (MBW) with early and late gestational diabetes mellitus (GDM). METHODS: A total of 69318 pregnant Japanese women were included in this birth cohort study. The associations between maternal birth weight and early gestational diabetes mellitus (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were investigated using a multinomial logistic regression model, with an maternal birth weight of 3000-3499 g as the reference category. RESULTS: Lower maternal birth weight was associated with higher odds of developing early and late gestational diabetes mellitus (P < 0.0001 and P < 0.0001, respectively). The adjusted odds ratios (aORs) for early gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were 1.345 (95% confidence interval [CI]: 0.912-1.984) and 1.338 (95% CI: 1.098-1.629), respectively. The aORs for late gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were, 1.657 (95% CI: 1.298-2.115) and 1.218 (95% CI: 1.058-1.402), respectively. CONCLUSIONS: Regardless of the gestational age when gestational diabetes mellitus was diagnosed, a lower maternal birth weight was associated with an increased risk of gestational diabetes mellitus. Furthermore, the association of a MBW <2500 g with late gestational diabetes mellitus tended to be stronger than that with early gestational diabetes mellitus.

  110. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis　2024/02/06

    DOI： 10.5551/jat.64535 　

    More details Close

    AIMS: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. METHODS: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C ≥ 140 mg/dL and/or dyslipidemia treatment. Multivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. RESULTS: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. CONCLUSIONS: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.

  111. 添付文書で妊婦に対して禁忌に設定されている医薬品の特定と国際比較

    酒井 隆全, 佐藤 ユリ, 畠山 史朗, 菊池 大輔, 土屋 雅美, 近藤 悠希, 佐藤 泉美, 岡田 裕子, 小原 拓

    医薬品情報学　25　(4)　211-219　2024/02

    Publisher: (一社)日本医薬品情報学会

    ISSN： 1345-1464

    eISSN： 1883-423X

  112. Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children’s Study

    Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Masatoshi Saito, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

    Nutrients　16　(4)　2024/02

    DOI： 10.3390/nu16040531 　

    eISSN： 2072-6643

  113. The impact of maternal and paternal birth weights on infant birth weights: the Japan environment and children's study. International-journal

    Hasumi Tomita, Noriyuki Iwama, Hirotaka Hamada, Rie Kudo, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

    Journal of developmental origins of health and disease　1-12　2024/01/22

    DOI： 10.1017/S2040174423000387 　

    More details Close

    This study aimed to evaluate the association between parental and infant birth weights in Japan. In total, 37,504 pregnant Japanese women and their partners were included in this birth cohort study. A multinomial logistic regression model was used to evaluate the associations of parental birth weights with small-for-gestational-age (SGA) or large-for-gestational-age (LGA) infants. Associations between parental birth weight and low birth weight (LBW) infants or macrosomia were also examined, and linear associations between parental birth weight and SGA or LGA were found. The adjusted odds ratios (aORs) for SGA infants per 500 g decrease in maternal and paternal birth weights were 1.50 (95% confidence interval [CI],1.43-1.58) and 1.31 (95% CI, 1.25-1.38), respectively. The aORs for LGA infants per 500 g increase in maternal and paternal birth weights were 1.53 (95% CI, 1.47-1.60) and 1.41 (95% CI, 1.35-1.47), respectively. The association between parental birth weight and LBW infants or macrosomia was also linear. The aORs for LBW infants per 500 g decrease in maternal and paternal birth weights were 1.47 (95% CI, 1.40-1.55) and 1.25 (95% CI, 1.19-1.31), respectively. The aORs for macrosomia per 500 g increase in maternal and paternal birth weights were 1.59 (95% CI, 1.41-1.79) and 1.40 (95% CI, 1.23-1.60), respectively. Parental birth weight was found to be associated with infant birth weight even after adjusting for various parental factors. Furthermore, maternal birth weight was more strongly associated with infant birth weight than with paternal birth weight.

  114. Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. International-journal

    Aoi Noda, Taku Obara, Fumiko Matsuzaki, Satoko Suzuki, Ryutaro Arita, Minoru Ohsawa, Ryo Obara, Kei Morishita, Fumihiko Ueno, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Hiroshi Kawame, Shigeo Kure, Shinichi Kuriyama

    Drugs - real world outcomes　2024/01/19

    DOI： 10.1007/s40801-023-00411-0 　

    More details Close

    BACKGROUND: Japanese traditional (Kampo) medicines containing ephedra may be used to treat colds during pregnancy. There are reports that ephedrine, a component of ephedra, has a risk of teratogenicity; however, the evidence remains equivocal. OBJECTIVE: This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with exposure to Kampo medicines containing ephedra during the first trimester of pregnancy using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: To 23,730 mother-infant pairs who participated in the TMM BirThree Cohort Study from July 2013 to March 2017, questionnaires in early and middle pregnancy were distributed approximately at weeks 12 and 26 of pregnancy, respectively. Infants' risk of MCMs in women who used Kampo medicines containing ephedra or acetaminophen during the first trimester was assessed, and the odds ratios (ORs) were estimated with unadjusted and adjusted analyses. RESULTS: Among 20,879 women, acetaminophen and Kampo medicines containing ephedra were used in 665 (3.19%) and 376 (1.80%) women, respectively, in the first trimester. Among the infants born to the mothers who used acetaminophen or Kampo medicine containing ephedra during the first trimester, 11 (1.65%) and 8 (2.13%), respectively, had overall MCMs. OR of overall MCMs was higher in women who used Kampo medicines containing ephedra than in those who used acetaminophen in the first trimester (adjusted OR, 1.45; 95% confidence interval (CIs), 0.57-3.71); however, the difference was not statistically significant. CONCLUSIONS: In this study, there was no statistically significant association between the use of Kampo medicines containing ephedra during the first trimester of pregnancy and the risk of MCMs. Although some point estimates of ORs exceeded 1.00, the absolute magnitude of any increased risks would be low.

  115. Trends in Anti-Influenza Drug Prescription and Adverse Drug Reaction Reporting After the Lifting of Oseltamivir Prescribing Restrictions in Pediatric Outpatients: An Ecological Study Using the MDV Analyzer® And the Japanese Adverse Drug Event Report Database

    Misaki Tokunaga, Daisuke Kikuchi, Aoi Noda, Sachiko Oikawa, Makoto Shiozawa, Hiroaki Hino, Ryosuke Miura, Kensuke Usui, Taku Obara, Kouji Okada

    Drugs - Real World Outcomes　2024/01/18

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s40801-023-00414-x 　

    ISSN： 2199-1154

    eISSN： 2198-9788

  116. Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis. International-journal

    Mami Ishikuro, Tomoko Nishimura, Hiroyoshi Iwata, Hirohito Metoki, Taku Obara, Noriyuki Iwama, Keiko Murakami, Md Shafiur Rahman, Maki Tojo, Sumitaka Kobayashi, Chihiro Miyashita, Keiko Tanaka, Yoshihiro Miyake, Kazue Ishitsuka, Reiko Horikawa, Naho Morisaki, Midori Yamamoto, Kenichi Sakurai, Chisato Mori, Atsushi Shimizu, Fumihiro Sata, Kenji J Tsuchiya, Reiko Kishi, Shinichi Kuriyama

    Journal of human hypertension　2024/01/10

    DOI： 10.1038/s41371-023-00890-2 　

  117. Evaluation of hospital pharmacists’ activities using additional reimbursement for infection prevention as an indicator in small and medium-sized hospitals

    Yuichi Tasaka, Takeshi Uchikura, Shiro Hatakeyama, Daisuke Kikuchi, Masami Tsuchiya, Ryohkan Funakoshi, Taku Obara

    Journal of Pharmaceutical Health Care and Sciences　10　(1)　2024/01/10

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40780-023-00327-5 　

    eISSN： 2055-0294

    More details Close

    Abstract Background Hospitals in Japan established the healthcare delivery system from FY 2018 to 2021 by acquiring an additional reimbursement for infection prevention (ARIP) of category 1 or 2. However, research on outcomes of ARIP applications related to the practice of hospital pharmacists is scarce. Methods This study assessed the activities performed by hospital pharmacists in hospitals with 100 to 299 beds, using ARIP acquirement as an indicator, using data from an annual questionnaire survey conducted in 2020 by the Japanese Society of Hospital Pharmacists on the status of hospital pharmacy departments. Out of the survey items, this study used those related to hospital functions, number of beds, number of pharmacists, whether the hospital is included in the diagnosis procedure combination (DPC) system, average length of stay, and nature of work being performed in the analysis. The relationship between the number of beds per pharmacist and state of implementation of pharmacist services or the average length of hospital stay was considered uncorrelated when the absolute value of the correlation coefficient was within 0–0.2, whereas the relationship was considered to have a weak, moderate, or strong correlation when the absolute value ranged at 0.2–0.4, 0.4–0.7, or 0.7–1, respectively. Results Responses were received from 3612 (recovery rate: 43.6%) hospitals. Of these, 210 hospitals meeting the criteria for ARIP 1 with 100–299 beds, and 245 hospitals meeting the criteria for ARIP 2 with 100–299 beds, were included in our analysis. There was a significant difference in the number of pharmacists, with a larger number in ARIP 1 hospitals. For the pharmacist services, significant differences were observed, with a more frequency in ARIP 1 hospitals in pharmaceutical management and guidance to pre-hospitalization patients, sterile drug processing of injection drugs and therapeutic drug monitoring. In DPC hospitals with ARIP 1 (173 hospitals) and 2 (105 hospitals), the average number of beds per pharmacist was 21.7 and 24.7, respectively, while the average length of stay was 14.3 and 15.4 d, respectively. Additionally, a weak negative correlation was observed between the number of pharmacist services with “Fairly well” or “Often” and the number of beds per pharmacist for both ARIP 1 (R = -0.207) and ARIP 2 (R = -0.279) DPC hospitals. Furthermore, a weak correlation (R = 0.322) between the average number of beds per pharmacist and the average length of hospital stay was observed for ARIP 2 hospitals. Conclusions Our results suggest that lower beds per pharmacist might lead to improved pharmacist services in 100–299 beds DPC hospitals with ARIP 1 or 2. The promotion of proactive efforts in hospital pharmacist services and fewer beds per pharmacist may relate to shorter hospital stays especially in small and medium-sized hospitals with ARIP 2 when ARIP acquisition was used as an indicator. These findings may help to accelerate the involvement of hospital pharmacists in infection control in the future.

  118. 尿中Na、K、Na/K比と胃がん罹患との関連 東北メディカル・メガバンク計画地域住民コホート調査

    小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 小原 拓, 永家 聖, 布施 昇男, 泉 陽子, 栗山 進一, 中谷 直樹, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　100-100　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  119. 東北メディカル・メガバンク計画 地域住民コホート調査(宮城) これまでの進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 石黒 真美, 大類 真嗣, 野田 あおい, 篠田 元気, 小原 拓, 宇留野 晃, 布施 昇男, 泉 陽子, 栗山 進一, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　133-133　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  120. ToMMo地域住民コホート調査におけるPreserved ratio impairment spirometryの有病と関連する要因の検討

    岩崎 史, 中谷 久美, 山田 充啓, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 小原 拓, 石黒 真美, 大類 真嗣, 永家 聖, 中村 智洋, 荻島 創一, 布施 昇男, 泉 陽子, 栗山 進一, 杉浦 久敏, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　139-139　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  121. Alcohol Flushingと悪性腫瘍有病の関連 TMM計画地域住民コホート調査(宮城)

    土谷 祐馬, 中谷 久美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 小原 拓, 石黒 真美, 大類 正嗣, 永家 聖, 中村 智洋, 荻島 創一, 布施 昇男, 泉 陽子, 栗山 進一, 亀井 尚, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　154-154　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  122. 産後うつ・自殺問題の縦断的リスクと関連要因の検討 東北メディカル・メガバンク計画三世代コホート調査

    大類 真嗣, 小原 拓, 石黒 真美, 野田 あおい, 篠田 元気, 村上 慶子, 岩間 憲之, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 目時 弘仁, 菊谷 昌浩, 中谷 直樹, 寳澤 篤, 栗山 進一

    Journal of Epidemiology　34　(Suppl.)　158-158　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  123. 震災による自宅損壊および心的外傷後ストレス反応と修正可能な認知症の危険因子の関連

    千葉 一平, 小暮 真奈, 中谷 久美, 畑中 里衣子, 小原 拓, 丹野 高三, 栗山 進一, 中谷 直樹, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　174-174　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  124. Temporal trends in antipsychotic prescriptions for pediatric patients using an administrative hospital database in Japan: a retrospective study Peer-reviewed

    Daisuke Kikuchi, Taku Obara, Ryo Obara, Hiroaki Hino, Naoto Suzuki, Shota Kashiwagura, Takashi Watanabe, Ryusuke Ouchi, Kensuke Usui, Kouji Okada

    Journal of Pharmaceutical Health Care and Sciences　10　2024/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40780-023-00324-8 　

    eISSN： 2055-0294

    More details Close

    Abstract Background Schizophrenia is a psychiatric disorder characterized by hallucinations, delusions, and other symptoms. Although treatment guidelines for schizophrenia have been established in Japan, drugs are not recommended for pediatric schizophrenia. Additionally, the temporal trends in prescribing antipsychotics for pediatric patients with schizophrenia are unclear. Therefore, we aimed to clarify the trends in antipsychotic prescriptions for Japanese pediatric outpatients from 2015 to 2022. Methods Administrative data (as of November 2023) of Japanese pediatric outpatients with schizophrenia aged 0–18 years who visited acute-care diagnosis procedure combination hospitals between January 1, 2015, and December 31, 2022, were included in this study. The target drugs for schizophrenia were all indicated for treating schizophrenia and marketed in Japan as of December 2022. Annual prescription trends for antipsychotics during this period were calculated based on their proportions. The Cochran–Armitage trend test was used to evaluate the proportion of prescriptions for each antipsychotic. Results The main drugs prescribed for these patients were aripiprazole and risperidone. Among male patients, the proportion of prescriptions for aripiprazole increased significantly from 21.2% in 2015 to 35.9% in 2022, whereas that for risperidone decreased significantly from 47.9% in 2015 to 36.7% in 2022 (both P &lt; 0.001). Among female patients, the proportion of prescriptions for aripiprazole increased significantly from 21.6% in 2015 to 35.6% in 2022, whereas that for risperidone decreased significantly from 38.6% in 2015 to 24.8% in 2022 (both P &lt; 0.001). Conclusions Aripiprazole and risperidone were primarily prescribed for pediatric schizophrenia in Japan during the study period. Additionally, the proportion of aripiprazole prescriptions increased over time.

  125. Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Misato Aizawa, Keiko Murakami, Ippei Takahashi, Hisashi Ohseto, Aoi Noda, Genki Shinoda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama

    Nutrition journal　22　(1)　66-66　2023/12/06

    DOI： 10.1186/s12937-023-00901-5 　

    More details Close

    BACKGROUND: Although an association between maternal nutritional intake and developmental delays in children has been demonstrated, the association of the timing of meal intake and development delays remains unclear. We examined the association between breakfast intake frequency before and during pregnancy and developmental delay in children. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 7491 answered the required questions and were analyzed. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: daily, and 5-6, 3-4, and 0-2 times/week. Child developmental delays at age 2 and 3.5 years were assessed using the Ages & Stages Questionnaire, Third Edition. Logistic regression models were constructed to examine the association between breakfast intake frequency in pregnant women and developmental delays in children aged 2 and 3.5 years. RESULTS: The proportion of pregnant women who had breakfast daily was 78.1% in pre- to early pregnancy, and 82.2% in early to mid-pregnancy. The proportion of children with developmental delays was 14.7% and 13.4% at age 2 and 3.5 years, respectively. Compared with the risk in children of women who had breakfast daily from pre- to early pregnancy, children of women who had breakfast 0-2 times/week had a higher risk of developmental delays at 2 years of age: odds ratio (OR) 1.30, (95% confidence interval [CI], 1.02-1.66). The risk of developmental delays at age 2 years increased in the children of women who had breakfast 0-2 times/week in early to mid- pregnancy: OR 1.75 (95% CI, 1.32-2.32). The risk of developmental delays at age 3.5 years did not increase in the children of women who had breakfast 0-2 times/week from pre- to early and early to mid-pregnancy: OR 1.06 (95% CI, 0.81-1.39 and OR 1.15 (95% CI 0.84-1.57), respectively. CONCLUSION: For women with a low frequency of breakfast intake from pre- to mid-pregnancy there was an association with developmental delays in their children at age 2, but not at 3.5 years.

  126. Maternal birth weight as an indicator of early-onset and late-onset hypertensive disorders of pregnancy: The Japan Environment and Children's study. International-journal

    Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

    Pregnancy hypertension　34　159-168　2023/11/21

    DOI： 10.1016/j.preghy.2023.11.002 　

    More details Close

    OBJECTIVES: This study aimed to investigate the association between maternal birth weight (MBW) and hypertensive disorders of pregnancy (HDP) according to the gestational age when HDP develops. STUDY DESIGN: A total of 77,345 subjects were included in this prospective birth cohort study. The association between MBW and HDP was investigated by a multinomial logistic regression model. MAIN OUTCOME MEASURES: Early-onset HDP (EO-HDP), preterm late-onset HDP (preterm LO-HDP), and term late-onset HDP (term LO-HDP). RESULTS: Lower MBW was associated with higher odds of preterm and term LO-HDP (p-values for trend < 0.0001 and = 0.0005, respectively). A linear association between MBW and EO-HDP was observed (p-values for trend = 0.0496). The shape of the association between MBW and preterm LO-HDP was a combination of the associations between MBW with EO-HDP or LO-HDP. The effect size of the association between MBW < 2,500 g and EO-HDP was lower than that of MBW < 2,500 g with preterm or term LO-HDP. The adjusted odds ratios for EO-HDP, preterm LO-HDP, and term LO-HDP in subjects with MBW < 2,500 g were 1.052 (95 % confidence interval [CI]: 0.665-1.664), 1.745 (95 % CI: 1.220-2.496), and 1.496 (95 % CI: 1.154-1.939), respectively. CONCLUSIONS: MBW was associated with HDP, regardless of gestational age when HDP developed. Furthermore, the association of MBW < 2,500 g with preterm or term LO-HDP was stronger than that with EO-HDP.

  127. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. International-journal

    Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　2023/10/31

    DOI： 10.1038/s41440-023-01484-8 　

    More details Close

    Masked hypertension is a risk factor for cardiovascular diseases. However, masked hypertension is sometimes overlooked owing to the requirement for home blood pressure measurements for diagnosing. Mental status influences blood pressure. To reduce undiagnosed masked hypertension, this study assessed the association between depressive symptoms and masked hypertension. This cross-sectional study used data from the Tohoku Medical Megabank Project Community-Based Cohort Study (conducted in Miyagi Prefecture, Japan, from 2013) and included participants with normotension measured at the research center (systolic blood pressure<140 mmHg and diastolic blood pressure <90 mmHg). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (Japanese version). Masked hypertension was defined as normotension measured at the research center and home hypertension (home systolic blood pressure ≥135 mmHg or home diastolic blood pressure ≥85 mmHg). The study comprised 6705 participants (mean age: 55.7 ± 13.7 years). Of these participants, 1106 (22.1%) without depressive symptoms and 393 (23.2%) with depressive symptoms were categorized to have masked hypertension. Sex-specific and age-adjusted least mean squares for home blood pressure, not for research blood pressure were significantly higher in the group with depressive symptoms in both sex categories. The multivariate odds ratio for masked hypertension in the patients with depressive symptoms was 1.72 (95% confidence interval: 1.26-2.34) in male participants and 1.30 (95% confidence interval: 1.06-1.59) in female ones. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at the research center. Depressive symptoms may be one of the risk factors for masked hypertension. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.

  128. The impact of clinical inertia on uncontrolled blood pressure in treated hypertension: real-world, longitudinal data from Japan. International-journal

    Michihiro Satoh, Tomoko Muroya, Takahisa Murakami, Taku Obara, Kei Asayama, Takayoshi Ohkubo, Yutaka Imai, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　2023/10/23

    DOI： 10.1038/s41440-023-01452-2 　

    More details Close

    We aimed to quantify the impact of inadequate pharmacological therapy on uncontrolled blood pressure (BP) using Japanese real-world data. This retrospective cohort study used databases provided by DeSC Healthcare, Inc (Tokyo, Japan). We identified 27,652 patients with hypertension (age, 60.7 ± 9.1 years; men, 56.4%) who were not receiving antihypertensive treatment at the initial visit (pre-treatment) and were under treatment at the next visit (post-treatment). Patients were classified into the following groups by the number of antihypertensive drug classes and defined daily dose (DDD): one antihypertensive drug class with a low dose (DDD < 1.0), one antihypertensive drug class with a moderate-to-high dose (DDD ≥ 1.0), two antihypertensive drug classes with a low dose (DDD < 2.0), two antihypertensive drug classes with a moderate-to-high dose (DDD ≥ 2.0), and ≥three antihypertensive drug classes. The pre-treatment systolic/diastolic BP was 157.7 ± 15.4/94.2 ± 11.5 mmHg. Overall, 43.0% of patients had uncontrolled BP (post-treatment BP ≥ 140/ ≥ 90 mmHg). High pre-treatment BP was a strong factor for uncontrolled BP. After adjustments for covariates, including the pre-treatment mean BP, the proportion of patients with uncontrolled BP was 2.08 times higher in the one antihypertensive drug class with a low dose group than in the ≥three antihypertensive drug classes group. The preventable fraction due to <three antihypertensive drug classes for uncontrolled BP was 40.6%. Only 9.9% of patients with the pre-treatment BP ≥ 180/ ≥ 110 mmHg were prescribed ≥ three antihypertensive drug classes. High pre-treatment BP and inadequate antihypertensive treatment were major factors contributing to uncontrolled BP. Adequate treatment intensification would resolve approximately 40% of uncontrolled BP cases among Japanese patients treated for hypertension. 27,652 Japanese patients treated with antihypertensive medications.

  129. The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study

    Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Hideaki Hashimoto, Tomohiro Nakamura, Kotaro Nochioka, Taku Obara, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Akira Uruno, Eiichi N. Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension Research　2023/10/13

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-023-01454-0 　

    ISSN： 0916-9636

    eISSN： 1348-4214

    More details Close

    Abstract This study aimed to examine whether risk of withdrawal from HTTx was higher in coastal areas that were severely damaged by tsunami than in inland areas. We conducted a cross-sectional study of 9218 participants aged ≥20 years in Miyagi, Japan. The odds ratios (ORs) and confidence interval (CI) for withdrawal from HTTx in coastal and inland groups were compared using multivariate logistic regression analysis, adjusting for potential confounders. In total, 194 of 5860 and 146 of 3358 participants in the inland and coastal groups, respectively, withdrew from HTTx treatment. OR (95%CI) of withdrawal from HTTx in the coastal group was 1.46 (1.14–1.86) compared to the inland group. According to housing damage, ORs (95% CI) in the no damage, partially destroyed, and more than half destroyed coastal groups compared with the no damage inland group were 1.62 (1.04–2.50), 1.69 (1.17–2.45), and 1.08 (0.71–1.65), respectively. In conclusion, the risk of HTTx withdrawal for participants whose homes in coastal areas were relatively less damaged was significantly higher compared with those in inland areas, while the risk of HTTx withdrawal for participants whose homes were more than half destroyed was not. Post-disaster administrative support for disaster victims is considered vital for continuation of their treatment.

  130. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Journal of atherosclerosis and thrombosis　2023/10/06

    DOI： 10.5551/jat.64425 　

    More details Close

    AIM: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. METHODS: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. RESULTS: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92-7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73-6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65-3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. CONCLUSIONS: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.

  131. 向精神薬服用中の母乳育児の実態と児への影響 授乳プランシートの結果から

    菊地 紗耶, 小林 奈津子, 小原 拓, 岩渕 理子, 齋藤 昌利, 木村 涼子, 岩渕 賢嗣, 富田 博秋

    日本周産期メンタルヘルス学会学術集会抄録集　19回　114-114　2023/10

    Publisher: 日本周産期メンタルヘルス学会

  132. 東北メディカル・メガバンク計画三世代コホート調査 これまでの進捗

    大類 真嗣, 小原 拓, 石黒 真美, 野田 あおい, 篠田 元気, 村上 慶子, 菅野 郁美, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 中谷 直樹, 寶澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　82回　370-370　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  133. 東北メディカル・メガバンク計画三世代コホート調査における追加リクルート

    石黒 真美, 小原 拓, 野田 あおい, 篠田 元気, 大類 真嗣, 村上 慶子, 菅野 郁美, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 中谷 直樹, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　82回　370-370　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  134. コホート調査データの連係・活用推進のための基盤整備 マイToMMoの開発と実装

    野田 あおい, 篠田 元気, 石黒 真美, 千葉 一平, 大類 真嗣, 村上 慶子, 小原 拓, 菅野 郁美, 中谷 久美, 畑中 里衣子, 小暮 真奈, 中谷 直樹, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　82回　371-371　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  135. 東北メディカル・メガバンク計画地域住民コホート調査(宮城) これまでの進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 石黒 真美, 大類 真嗣, 野田 あおい, 篠田 元気, 村上 慶子, 小原 拓, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集　82回　398-398　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  136. Real-world prevalence, time of diagnosis, and co-occurrence patterns of birth defects in live-born infants, 2014-2020: A health administrative database study in Japan. International-journal

    Tomofumi Ishikawa, Hiroshi Kawame, Nariyasu Mano, Taku Obara

    Birth defects research　115　(18)　1723-1736　2023/09/08

    DOI： 10.1002/bdr2.2247 　

    More details Close

    BACKGROUND: A study evaluating the real-world prevalence of birth defects (BDs), including co-occurrence patterns, will provide the information required to estimate Japan's true BD prevalence and monitor it. Information such as when infants are diagnosed with BDs is crucial for defining the study population and data collection period in future administrative database studies. METHODS: This study utilized the DeSC database, a large claims database comprising multiple health insurance schemes. The prevalence of major BDs, including structural congenital malformations (CMs) and chromosomal abnormalities, was determined in infants born between 2014 and 2020 and continuously insured for ≥1 year. The time of the first BD diagnosis and multiple BD patterns were also evaluated. RESULTS: Among 43,147 infants, 3050 (7.07%) were diagnosed with major BDs, and 3002 (6.96%) with major CMs. The circulatory system (2.95%) was the most frequent organ system affected by CMs, followed by CMs and deformations of the musculoskeletal system (1.94%). The cumulative diagnostic rates of BDs and CMs at month 6 were 85.9% and 85.6%, respectively. The EUROCAT BD subgroups diagnosed in more than 1.0% of the infants were atrial septal defects (1.47%) and patent ductus arteriosus (1.07%). Among the 2997 infants with EUROCAT BDs, 241 (8.04%) were classified as having multiple BDs. CONCLUSIONS: A large claims database is a valuable resource for evaluating and monitoring the prevalence of BDs, including multiple patterns. At least 1 year since birth should be considered in future administrative database studies evaluating BDs as outcomes.

  137. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　45回　261-261　2023/09

    Publisher: (NPO)日本高血圧学会

  138. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　45回　358-358　2023/09

    Publisher: (NPO)日本高血圧学会

  139. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　45回　261-261　2023/09

    Publisher: (NPO)日本高血圧学会

  140. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　45回　358-358　2023/09

    Publisher: (NPO)日本高血圧学会

  141. Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. International-journal

    Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama, Taku Obara, Mami Ishikuro, Hiroshi Tanaka, Kengo Kinoshita, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Soichi Ogishima

    BMC pregnancy and childbirth　23　(1)　628-628　2023/08/31

    DOI： 10.1186/s12884-023-05919-5 　

    More details Close

    BACKGROUND: Low birth weight (LBW) is a leading cause of neonatal morbidity and mortality, and increases various disease risks across life stages. Prediction models of LBW have been developed before, but have limitations including small sample sizes, absence of genetic factors and no stratification of neonate into preterm and term birth groups. In this study, we challenged the development of early prediction models of LBW based on environmental and genetic factors in preterm and term birth groups, and clarified influential variables for LBW prediction. METHODS: We selected 22,711 neonates, their 21,581 mothers and 8,593 fathers from the Tohoku Medical Megabank Project Birth and Three-Generation cohort study. To establish early prediction models of LBW for preterm birth and term birth groups, we trained AI-based models using genetic and environmental factors of lifestyles. We then clarified influential environmental and genetic factors for predicting LBW in the term and preterm groups. RESULTS: We identified 2,327 (10.22%) LBW neonates consisting of 1,077 preterm births and 1,248 term births. Our early prediction models archived the area under curve 0.96 and 0.95 for term LBW and preterm LBW models, respectively. We revealed that environmental factors regarding eating habits and genetic features related to fetal growth were influential for predicting LBW in the term LBW model. On the other hand, we identified that genomic features related to toll-like receptor regulations and infection reactions are influential genetic factors for prediction in the preterm LBW model. CONCLUSIONS: We developed precise early prediction models of LBW based on lifestyle factors in the term birth group and genetic factors in the preterm birth group. Because of its accuracy and generalisability, our prediction model could contribute to risk assessment of LBW in the early stage of pregnancy and control LBW risk in the term birth group. Our prediction model could also contribute to precise prediction of LBW based on genetic factors in the preterm birth group. We then identified parental genetic and maternal environmental factors during pregnancy influencing LBW prediction, which are major targets for understanding the LBW to address serious burdens on newborns' health throughout life.

  142. Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 Years. International-journal

    Ippei Takahashi, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Tomoko Nishimura, Kenji J Tsuchiya, Shinichi Kuriyama

    JAMA pediatrics　2023/08/21

    DOI： 10.1001/jamapediatrics.2023.3057 　

    More details Close

    IMPORTANCE: Whether some domains of child development are specifically associated with screen time and whether the association continues with age remain unknown. OBJECTIVE: To examine the association between screen time exposure among children aged 1 year and 5 domains of developmental delay (communication, gross motor, fine motor, problem-solving, and personal and social skills) at age 2 and 4 years. DESIGN, PARTICIPANTS, AND SETTING: This cohort study was conducted under the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Pregnant women at 50 obstetric clinics and hospitals in the Miyagi and Iwate prefectures in Japan were recruited into the study between July 2013 and March 2017. The information was collected prospectively, and 7097 mother-child pairs were included in the analysis. Data analysis was performed on March 20, 2023. EXPOSURE: Four categories of screen time exposure were identified for children aged 1 year (<1, 1 to <2, 2 to <4, or ≥4 h/d). MAIN OUTCOMES AND MEASURES: Developmental delays in the 5 domains for children aged 2 and 4 years were assessed using the Japanese version of the Ages & Stages Questionnaires, Third Edition. Each domain ranged from 0 to 60 points. Developmental delay was defined if the total score for each domain was less than 2 SDs from its mean score. RESULTS: Of the 7097 children in this study, 3674 were boys (51.8%) and 3423 were girls (48.2%). With regard to screen time exposure per day, 3440 children (48.5%) had less than 1 hour, 2095 (29.5%) had 1 to less than 2 hours, 1272 (17.9%) had 2 to less than 4 hours, and 290 (4.1%) had 4 or more hours. Children's screen time was associated with a higher risk of developmental delay at age 2 years in the communication (odds ratio [OR], 1.61 [95% CI, 1.23-2.10] for 1 to <2 h/d; 2.04 [1.52-2.74] for 2 to <4 h/d; 4.78 [3.24-7.06] for ≥4 vs <1 h/d), fine motor (1.74 [1.09-2.79] for ≥4 vs <1 h/d), problem-solving (1.40 [1.02-1.92] for 2 to <4 h/d; 2.67 [1.72-4.14] for ≥4 vs <1 h/d), and personal and social skills (2.10 [1.39-3.18] for ≥4 vs <1 h/d) domains. Regarding risk of developmental delay at age 4 years, associations were identified in the communication (OR, 1.64 [95% CI, 1.20-2.25] for 2 to <4 h/d; 2.68 [1.68-4.27] for ≥4 vs <1 h/d) and problem-solving (1.91 [1.17-3.14] for ≥4 vs <1 h/d) domains. CONCLUSIONS AND RELEVANCE: In this study, greater screen time for children aged 1 year was associated with developmental delays in communication and problem-solving at ages 2 and 4 years. These findings suggest that domains of developmental delay should be considered separately in future discussions on screen time and child development.

  143. 新生児臍帯血の網羅的エピゲノム解析による妊娠初期までの喫煙経験が次世代に及ぼす影響

    美辺 詩織, 小巻 翔平, 大桃 秀樹, 高嶋 聰, 小野 加奈子, 山崎 弥生, 須藤 洋一, 田高 周, 水野 聖士, 石黒 真美, 工藤 久智, 小原 拓, 熊田 和貴, 勝岡 史城, 荻島 創一, 木下 賢吾, 菅原 準一, 栗山 進一, 清水 厚志

    DOHaD研究　11　(3)　37-37　2023/08

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  144. 母親の妊娠中と産後の心理的苦痛と4歳時点における児の発達との関連 三世代コホート調査

    高橋 一平, 小原 拓, 菊地 紗耶, 小林 美佳, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 小林 奈津子, 濱田 裕貴, 岩間 憲之, 齋藤 昌利, 菅原 準一, 富田 博秋, 呉 繁夫, 八重樫 伸生, 栗山 進一

    DOHaD研究　11　(3)　29-29　2023/08

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  145. 妊娠初期の消化管運動改善薬の大奇形リスク 大規模レセプトデータベースを用いた評価

    小原 拓, 石川 智史, 赤沢 学, 野田 あおい, 大柳 元, 森下 啓, 都田 桂子, 西郡 秀和, 川目 裕, 八重樫 伸生, 栗山 進一, 眞野 成康

    DOHaD研究　11　(3)　38-39　2023/08

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  146. Efficacy of exponentiation method with a convolutional neural network for classifying lung nodules on CT images by malignancy level

    Takuma Usuzaki, Kengo Takahashi, Hidenobu Takagi, Mami Ishikuro, Taku Obara, Takumi Yamaura, Masahiro Kamimoto, Kazuhiro Majima

    European Radiology　Epub ahead of print　2023/07/21

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00330-023-09946-w 　

    eISSN： 1432-1084

  147. Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.

    Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

    JMA journal　6　(3)　246-264　2023/07/14

    DOI： 10.31662/jmaj.2022-0220 　

    More details Close

    The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment.

  148. Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.

    Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Masato Takase, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Taku Obara, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Junichi Sugawara, Eiichi N Kodama, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis　2023/07/05

    DOI： 10.5551/jat.64151 　

    More details Close

    AIM: People with high normal blood pressure (BP) have a higher risk of cardiovascular events than those with normal BP; therefore, progression to hypertension (HT) should be prevented. We aimed to assess the HT risk using central BP and carotid intima media thickness (CIMT) in people with high normal BP. METHODS: This prospective cohort study used the Tohoku Medical Megabank Community-Based Project Cohort Study (conducted from 2013 in Miyagi Prefecture in Japan). The participants had a high normal BP, defined as a systolic BP of 120-139 mmHg and diastolic BP ＜90 mmHg using brachial BP measurement during the baseline survey. The outcome was new-onset HT during the secondary survey, conducted four years after the baseline survey. RESULTS: Overall, 4,021 participants with high normal BP during the baseline survey, with an average age of 58.7 years, were included; 1,030 (26%) were diagnosed with new-onset HT during the secondary survey, 3.5± 0.7 years after the baseline survey. The multivariable odds ratio (95% confidence interval) for HT in the highest versus lowest quartile of central BP was 1.7 (1.2-2.4, p=0.0030), and that of CIMT was 1.8 (1.4-2.4, p＜0.001). Subgroup analysis according to age (＜60 and ≥ 60 years) and sex revealed that the central BP was influential in groups with younger age and female individuals; CIMT was influential in all groups. CONCLUSIONS: Higher central BP and thicker CIMT at the baseline were correlated with new-onset HT in individuals with high normal BP, independent of brachial systolic BP and other cardiovascular risk factors.

  149. 産後女性のうつ・自殺関連問題の縦断的リスク評価の記述的分析 東北メディカル・メガバンク計画三世代コホート調査

    大類 真嗣, 小原 拓, 石黒 真美, 野田 あおい, 篠田 元気, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 中谷 直樹, 寳澤 篤, 栗山 進一

    東北公衆衛生学会誌　(72)　25-25　2023/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  150. Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability

    Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Ryoko Kimura, Yumiko Hamaie, Mizuki Hino, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Susumu Fujii, Masaharu Nakayama, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

    Frontiers in Psychiatry　14　2023/06/06

    Publisher: Frontiers Media SA

    DOI： 10.3389/fpsyt.2023.1104222 　

    eISSN： 1664-0640

    More details Close

    Introduction Perinatal women tend to have difficulties with sleep along with autonomic characteristics. This study aimed to identify a machine learning algorithm capable of achieving high accuracy in predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability (HRV). Methods Nine HRV indicators (features) and sleep–wake conditions of 154 pregnant women were measured for 1 week, from the 23rd to the 32nd weeks of pregnancy. Ten machine learning and three deep learning methods were applied to predict three types of sleep–wake conditions (wake, shallow sleep, and deep sleep). In addition, the prediction of four conditions, in which the wake conditions before and after sleep were differentiated—shallow sleep, deep sleep, and the two types of wake conditions—was also tested. Results and Discussion In the test for predicting three types of sleep–wake conditions, most of the algorithms, except for Naïve Bayes, showed higher areas under the curve (AUCs; 0.82–0.88) and accuracy (0.78–0.81). The test using four types of sleep–wake conditions with differentiation between the wake conditions before and after sleep also resulted in successful prediction by the gated recurrent unit with the highest AUC (0.86) and accuracy (0.79). Among the nine features, seven made major contributions to predicting sleep–wake conditions. Among the seven features, “the number of interval differences of successive RR intervals greater than 50 ms (NN50)” and “the proportion dividing NN50 by the total number of RR intervals (pNN50)” were useful to predict sleep–wake conditions unique to pregnancy. These findings suggest alterations in the vagal tone system specific to pregnancy.

  151. Factors associated with new onset of father-to-infant bonding failure from 1 to 6 months postpartum: an adjunct study of the Japan environment and children's study. International-journal

    Taeko Suzuki, Toshie Nishigori, Taku Obara, Miyuki Mori, Kasumi Sakurai, Mami Ishikuro, Hirotaka Hamada, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Hirohito Metoki, Shinichi Kuriyama, Aya Goto, Nobuo Yaegashi, Hidekazu Nishigori

    Social psychiatry and psychiatric epidemiology　58　(11)　1603-1624　2023/06/04

    DOI： 10.1007/s00127-023-02505-0 　

    More details Close

    PURPOSE: This study aimed to determine the factors associated with new onset father-to-infant (paternal) bonding failure from 1 to 6 months postpartum. METHODS: This was a prospective birth-cohort study. Paternal bonding failure was evaluated using the Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) at 1 and 6 months postpartum. For cut-off scores, overall bonding failure, MIBS-J total scores ≥ 5; subscale for lack of affection, MIBS-J_LA scores ≥ 3; and subscale for anger/rejection, MIBS-J_AR scores ≥ 3 were used in this study. Multivariate regression analysis was performed to analyze relative variables. RESULTS: We analyzed 872 fathers. The frequency of new-onset overall bonding failure, lack of affection, and anger/rejection was 5.6%, 4.9%, and 6.3%, respectively. For new-onset overall bonding failure, significant associated factors were paternal childcare leave (adjusted odds ratio [AOR] 3.192; 95% confidence interval [CI] 1.203-8.469), paternal new-onset depression symptoms (AOR 3.181; 95% Cl 1.311-7.716), and maternal new-onset overall bonding failure (AOR 4.595; 95% Cl 1.119-18.866). For new-onset lack of affection, significant associated factors were preterm birth (AOR 4.189; 95% Cl 1.473-11.913) and paternal new-onset depression symptoms (AOR 3.290; 95% Cl 1.294-8.362). For new-onset anger and rejection, significant associated factors were paternal childcare leave (AOR 3.142; 95% Cl 1.138-8.676), paternal new-onset depression symptoms (AOR 2.829; 95% Cl 1.133-7.068), and maternal new-onset anger/rejection (AOR 7.064; 95% Cl 2.300-21.700). CONCLUSIONS: The factors associated with new-onset paternal bonding failure from 1 to 6 months postpartum were paternal childcare leave, preterm birth, paternal postpartum depression symptoms, and maternal bonding failure.

  152. Maternal social isolation in the perinatal period and early childhood development: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Social psychiatry and psychiatric epidemiology　58　(11)　1593-1601　2023/06/03

    DOI： 10.1007/s00127-023-02498-w 　

    More details Close

    PURPOSE: Studies examining the associations between maternal social relationships and early childhood development have mainly focused on social relationships after childbirth. We aimed to prospectively examine the associations between the transition of maternal social isolation from the prenatal to postnatal period and early childhood development. METHODS: We analyzed data for 6692 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Social isolation in the prenatal and postnatal periods was assessed by the Lubben Social Network Scale-abbreviated version and categorized into four groups: none, prenatal only, postnatal only, and both. The Ages and Stages Questionnaire, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between maternal social isolation and developmental delays. RESULTS: The prevalence of social isolation in both the prenatal and postnatal periods was 13.1%. Social isolation in both the prenatal and postnatal periods was associated with developmental delays in children at 2 and 3.5 years of age: the multivariate-adjusted odds ratios (95% confidence intervals) were 1.68 (1.39-2.04) and 1.43 (1.17-1.76), respectively. Social isolation in the prenatal period only and social isolation in the postnatal period only were not associated with developmental delays in children at 2 and 3.5 years of age. CONCLUSION: Maternal social isolation in both the prenatal and postnatal periods was associated with an increased risk of developmental delays in early childhood.

  153. 妊婦における精神神経用剤服薬および心理的苦痛の有無と2歳時点の児の行動特性との関連

    高橋 一平, 小原 拓, 菊地 紗耶, 小林 奈津子, 小原 竜, 野田 あおい, 上野 史彦, 大沼 ともみ, 村上 慶子, 石黒 真美, 富田 博秋, 栗山 進一

    精神神経学雑誌　(2023特別号)　S584-S584　2023/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  154. Associations between sugar-sweetened beverages before and during pregnancy and offspring overweight/obesity in Japanese women: the TMM BirThree Cohort Study. International-journal

    Misato Aizawa, Keiko Murakami, Yudai Yonezawa, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

    Public health nutrition　26　(6)　1222-1229　2023/06

    DOI： 10.1017/S1368980023000307 　

    More details Close

    OBJECTIVE: The association between high sugar-sweetened beverages (SSB) intake during pregnancy and offspring overweight/obesity has been reported only from Western countries. The objective of this study was to examine the association between SSB intake before and during pregnancy and offspring overweight/obesity among Japanese women. DESIGN: Japanese prospective birth cohort study. SETTING: We analysed mother-offspring pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. SSB intake during pregnancy was evaluated using the FFQ and classified into three groups: none (0 g/d), medium (<195 g/d) and high (>195 g/d). Overweight or obesity at 1 year of age in offspring was defined as having a BMI Z-score greater than 2 sd, calculated based on the BMI reference data for Japanese children. Multiple logistic regression analyses were performed to examine the associations between SSB intake before and during pregnancy and offspring overweight/obesity, after adjusting for covariates. PARTICIPANTS: Japanese mother-offspring pairs (n 7114). RESULTS: The overweight/obesity rate of the offspring was 8·8 %. Pregnant women with a high intake of SSB in early to mid-pregnancy had a higher risk of overweight/obesity in their offspring compared with those who did not; the OR was 1·52 (95 % CI (1·09, 2·12)). CONCLUSIONS: High SSB intake in early to mid-pregnancy was associated with an increased risk of offspring overweight/obesity at 1 year of age.

  155. Association between being Overweight in Young Childhood and during School Age and Puberty. International-journal

    Genki Shinoda, Yudai Nagaoka, Fumihiko Ueno, Naoyuki Kurokawa, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

    Children (Basel, Switzerland)　10　(5)　2023/05/22

    DOI： 10.3390/children10050909 　

    More details Close

    To examine whether body type at birth, body weight, and obesity in early childhood are associated with overweight/obesity during school age and puberty. Data from maternal and child health handbooks, baby health checkup information, and school physical examination information of participants at birth and three-generation cohort studies were linked. Association between body type and body weight at different time intervals (at birth and at 1.5, 3.5, 6, 11, and 14 years of age) were comprehensively analyzed using a multivariate regression model adjusted for gender, maternal age at childbirth, maternal parity, and maternal body mass index, and drinking and smoking statuses at pregnancy confirmation. Children who are overweight in young childhood had a greater risk of being overweight. Particularly, overweight at one year of age during checkup was associated with overweight at 3.5 years (adjusted odds ratio (aOR), 13.42; 95% confidence interval (CI), 4.46-45.42), 6 years (aOR, 6.94; 95% CI, 1.64-33.46), and 11 years (aOR, 5.22; 95% CI, 1.25-24.79) of age. Therefore, being overweight in young childhood could increase the risk of being overweight and obese during school age and puberty. Early intervention in young childhood may be warranted to prevent obesity during school age and puberty.

  156. Association between low levels of anti-inflammatory cytokines during pregnancy and postpartum depression. International-journal

    Chiaki T Ono, Zhiqian Yu, Taku Obara, Mami Ishikuro, Keiko Murakami, Masahiro Kikuya, Saya Kikuchi, Natsuko Kobayashi, Hisaaki Kudo, Soichi Ogishima, Naoko Minegishi, Junichi Sugawara, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Hiroaki Tomita

    Psychiatry and clinical neurosciences　77　(8)　434-441　2023/05/13

    DOI： 10.1111/pcn.13566 　

    More details Close

    AIM: Previous studies based on a relatively limited number of subjects have indicated potential associations between plasma cytokine concentrations in perinatal women and postpartum depression (PPD). This report aimed to examine alterations in cytokine levels during pregnancy and after delivery by measuring nine cytokines in prenatal and postnatal plasma samples in a large cohort. METHODS: A nested, case-control study was conducted using plasma samples from 247 women with PPD (Edinburgh Postnatal Depression Scale: EPDS ≥9) and 243 age-matched control (EPDS ≤2) women from among perinatal women who participated in the Tohoku Medical Megabank three-generation cohort. Concentrations of nine plasma cytokines (IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, and TNF-α) in plasma collected at the time of enrollment during pregnancy and one month after delivery were determined using an immunoassay kit. RESULTS: Cross-sectional comparisons of cytokine levels during pregnancy and after delivery indicated that the PPD group maintained significantly lower plasma IL-4 levels during pregnancy and after delivery than the control group, and that plasma IL-4 levels decreased significantly during pregnancy regardless of PPD status. Plasma IL-10 levels were significantly higher during pregnancy than after delivery only among healthy controls, and plasma IL-10 levels were significantly higher in the control group than in the PPD group. Moreover, IFN-γ, IL-6, IL-12p40, and TNF-α levels were significantly lower during pregnancy compared with after delivery regardless of PPD status. CONCLUSIONS AND RELEVANCE: These results suggest a potential protective effect of the anti-inflammatory cytokines IL-4 and IL-10 during pregnancy against the development of PPD. This article is protected by copyright. All rights reserved.

  157. The prevalence of end-of-life chemotherapy and targeted therapy in Japan, assessed using a health claims database. International-journal

    Masami Tsuchiya, Taku Obara, Masafumi Kikuchi, Nariyasu Mano

    Cancer chemotherapy and pharmacology　2023/05/08

    DOI： 10.1007/s00280-023-04535-6 　

    More details Close

    PURPOSE: This study aimed to investigate the current status of end-of-life chemotherapy and targeted therapy and explore the aggressiveness of end-of-life care in Japan using the DeSC database, a large administrative claims database. METHODS: We identified fatal cases of at least one cancer-related diagnosis between April 2015 and November 2020. Patients prescribed at least one anticancer drug were analyzed, and chemotherapy regimens were categorized based on the combination of concomitant anticancer drugs prescribed. RESULTS: Among 1,095,713 individuals enrolled in the National Health Insurance database, 7,300 deaths with cancer-related diagnosis were identified. Of these, 4,010 cases were identified in which at least one anticancer drug was prescribed, and 11.6% of 7,300 death had been prescribed anticancer drugs in their last 30 days of life. The most commonly used regimen was S-1 (tegafur, gimeracil, and oteracil potassium combination) monotherapy, followed by nivolumab monotherapy and nab-paclitaxel plus gemcitabine. Immune checkpoint inhibitor monotherapy was more likely prescribed to patients whose last chemotherapy dose was in the last 30 days of life (p = 0.0066, chi-squared test). CONCLUSIONS: This study provides insights into the current status of end-of-life chemotherapy and targeted therapy in Japan, using a large administrative claims database. The results of this study will inform future research on end-of-life chemotherapy and targeted therapy, and help develop strategies to improve the quality of life of patients with advanced cancer.

  158. 高齢者における尿Na/K比の血圧への影響は非高齢者より大きい

    平田 匠, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 栗山 進一, 丹野 高三, 寳澤 篤

    日本老年医学会雑誌　60　(Suppl.)　178-178　2023/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  159. 抑うつ症状と家庭高血圧発症リスクの関連 東北メディカル・メガバンク計画地域住民コホート調査

    時岡 紗由理, 中谷 直樹, 中谷 久美, 小暮 真奈, 千葉 一平, 畑中 里衣子, 菅野 郁美, 小原 拓, 栗山 進一, 寳澤 篤

    日本循環器病予防学会誌　58　(2)　146-146　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  160. 血圧コントロール不良に対する不十分な高血圧薬物治療による影響 リアルワールドデータに基づく解析

    佐藤 倫広, 室谷 智子, 村上 任尚, 小原 拓, 浅山 敬, 大久保 孝義, 今井 潤, 目時 弘仁

    日本循環器病予防学会誌　58　(2)　146-146　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  161. 収縮期・拡張期血圧を用いた詳細血圧分類と慢性腎臓病発症リスクの関連

    末永 司, 佐藤 倫広, 村上 任尚, 廣瀬 卓男, 中山 晋吾, 小原 拓, 森 建文, 今井 潤, 大久保 孝義, 目時 弘仁

    日本循環器病予防学会誌　58　(2)　157-157　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  162. 慢性腎臓病発症に対する高血圧と糖尿病の複合効果

    遠山 真弥, 佐藤 倫広, 村上 任尚, 橋本 英明, 中山 晋吾, 小原 拓, 中谷 直樹, 森 建文, 大久保 孝義, 今井 潤, 寳澤 篤, 目時 弘仁

    日本腎臓学会誌　65　(3)　259-259　2023/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  163. Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

    BMC pregnancy and childbirth　23　(1)　268-268　2023/04/19

    DOI： 10.1186/s12884-023-05603-8 　

    More details Close

    BACKGROUND: Low birth weight is associated with an increased risk of developing chronic diseases in adulthood, with a particularly high incidence in Japan among developed countries. Maternal undernutrition is a risk factor for low birth weight, but the association between the timing of food intake and infant birth weight has not been investigated. This study aimed to examine the association between breakfast intake frequency among Japanese pregnant women and infant birth weight. METHODS: Of all pregnant women who participated in the Tohoku Medical Megabank Project Three Generation Cohort Study, 16,820 who answered the required questions were included in the analysis. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: every day and 5-6, 3-4, and 0-2 times/week. Multivariate linear regression models were constructed to examine the association between breakfast intake frequency among pregnant women and infant birth weight. RESULTS: The percentage of pregnant women who consumed breakfast daily was 74% in the pre- to early pregnancy period and 79% in the early to mid-pregnancy period. The average infant birth weight was 3,071 g. Compared to women who had breakfast daily from pre- to early pregnancy, those who had breakfast 0-2 times/week had lower infant birth weight (β = -38.2, 95% confidence interval [CI]: -56.5, -20.0). Similarly, compared to women who had breakfast daily from early to mid-pregnancy, those who had breakfast 0-2 times/week had lower infant birth weight (β = -41.5, 95% CI: -63.3, -19.6). CONCLUSIONS: Less frequent breakfast intake before and mid-pregnancy was associated with lower infant birth weight.

  164. Difficulties in Accessing Medication Records at the Time of a Large-Scale Disaster. International-journal

    Fumihiko Ueno, Keiko Murakami, Masato Nagai, Hiroko Matsubara, Tomomi Oonuma, Fumiko Matsuzaki, Aoi Noda, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

    Disaster medicine and public health preparedness　17　e370　2023/04/05

    DOI： 10.1017/dmp.2022.301 　

    More details Close

    OBJECTIVE: In a large-scale disaster, medical professionals need to access medication records and provide medicines to people who cannot return home to take their daily medicines. We investigated the proportion of carrying the paper notebook or availability of the smartphone application of the medication record among people who are assumed to have difficulty in taking their medicines during large-scale disasters. METHODS: In Japan, a web-based survey was conducted in 2018 by randomly selecting adults ≥ 20 years of age. RESULTS: There were 2286 medication record owners in 3082 participants. Of the medication record owners, 784 (34.3%) took medicines that could not be missed for even a day. Among them, 724 used paper notebooks alone, 26 used smartphone applications alone, and 34 used both. Among the 724, 208 (28.8%) always carried a paper notebook. Among the 26, 16 (61.5%) could use their applications anytime. Therefore, among the 784, at least 560 (71.4%) could not always access their medication information. CONCLUSIONS: An awareness campaign to carry paper notebooks and install applications for medication records should be held, since only a limited number of people carry their medication records and always have access to their medication information.

  165. Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards

    Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

    Acta Paediatrica, International Journal of Paediatrics　112　(4)　776-778　2023/04

    DOI： 10.1111/apa.16662 　

    ISSN： 0803-5253

    eISSN： 1651-2227

  166. Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards

    Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

    ACTA PAEDIATRICA　112　(4)　776-778　2023/04

    DOI： 10.1111/apa.16662 　

    ISSN： 0803-5253

    eISSN： 1651-2227

  167. Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards. International-journal

    Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

    Acta paediatrica (Oslo, Norway : 1992)　112　(4)　776-778　2023/04

    DOI： 10.1111/apa.16662 　

  168. Maternal social isolation and behavioral problems in preschool children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    European child & adolescent psychiatry　2023/03/30

    DOI： 10.1007/s00787-023-02199-4 　

    More details Close

    It is essential to clarify factors associated with mental health and behavioral problems in early childhood, because children are critical stages of life for mental health. We aimed to prospectively examine the associations between maternal social isolation and behavioral problems in preschool children. We analyzed data from 5842 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores < 12) one year after delivery. The Child Behavior Checklist 1½-5 was used to assess behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations between social isolation and behavioral problems, after adjustment for age, education, income, work status, marital status, extraversion, neuroticism, depressive symptoms, child sex, and number of siblings. Multiple logistic regression analyses were also conducted for internalizing problems and externalizing problems. The prevalence of maternal social isolation was 25.4%. Maternal social isolation was associated with an increased risk of behavioral problems in children: the odds ratio (OR) was 1.37 (95% confidence interval [CI] 1.14-1.64). Maternal social isolation was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.33 (95% CI, 1.12-1.59) and 1.40 (95% CI, 1.18-1.66), respectively. In conclusion, maternal social isolation one year after delivery was associated with behavioral problems in children at 4 years of age.

  169. Cross-classification by systolic and diastolic blood pressure levels and chronic kidney disease, proteinuria, or kidney function decline

    Tsukasa Suenaga, Michihiro Satoh, Takahisa Murakami, Takuo Hirose, Taku Obara, Shingo Nakayama, Hideaki Hashimoto, Maya Toyama, Tomoko Muroya, Atsuhiro Kanno, Takefumi Mori, Takayoshi Ohkubo, Yutaka Imai, Hirohito Metoki

    Hypertension Research　2023/03/30

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-023-01267-1 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  170. 母親における出産前後の社会的孤立と児の発達との関連 三世代コホート調査

    村上 慶子, 野田 あおい, 石黒 真美, 小原 拓, 上野 史彦, 菊地 紗耶, 小林 奈津子, 濱田 裕貴, 岩間 憲之, 目時 弘仁, 齋藤 昌利, 菅原 準一, 富田 博秋, 八重樫 伸生, 栗山 進一

    日本衛生学雑誌　78　(Suppl.)　S173-S173　2023/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  171. Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Archives of women's mental health　26　(2)　219-226　2023/02/21

    DOI： 10.1007/s00737-023-01298-0 　

    More details Close

    Although there is some evidence regarding an association between maternal bonding disorder and child development, studies have mainly focused on development during the period of infancy. We aimed to examine the associations between maternal postnatal bonding disorder and developmental delays in children beyond 2 years of age. We analyzed data from 8380 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score of ≥5 at 1 month after delivery. The Ages & Stages Questionnaires, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between postnatal bonding disorder and developmental delays after adjustment for age, education, income, parity, feelings toward pregnancy, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. Bonding disorder was associated with developmental delays in children at 2 and 3.5 years of age: the odds ratios (95% confidence intervals) were 1.55 (1.32-1.83) and 1.60 (1.34-1.90), respectively. Bonding disorder was associated with delay in communication only at 3.5 years of age. Bonding disorder was associated with delay in gross motor, fine motor, and problem solving, but not delay in the personal-social domain, at 2 and 3.5 years of age. In conclusion, maternal bonding disorder 1 month after delivery was associated with an increased risk of developmental delays in children beyond 2 years of age.

  172. Association between maternal psychological distress and children's neurodevelopment in offspring aged 4 years in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Ippei Takahashi, Taku Obara, Saya Kikuchi, Mika Kobayashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

    Journal of paediatrics and child health　59　(3)　548-554　2023/02/08

    DOI： 10.1111/jpc.16353 　

    More details Close

    AIM: An association between maternal psychological distress and children's development has been reported, but  reports from Japan are limited. This study aimed to examine the association of maternal psychological distress with children's neurodevelopment in Japan. METHODS: The study assessed data of 7646 mother-infant pairs in the Japanese population. We used Kessler Psychological Distress Scale, a screening tool for psychological distress, to assess maternal psychological distress in early pregnancy and 2 years postpartum and divided it into four categories: none in both the pre-natal and post-natal periods, only the pre-natal period, only the post-natal period and both the pre-natal and post-natal periods. Children's neurodevelopment was assessed using the Ages & Stages Questionnaires Third Edition (ASQ-3) at 4 years of age. ASQ-3 comprises five domains (communication, gross motor, fine motor, problem solving and personal-social), and the score of less than -2 standard deviation relative to the mean in reference was defined as having developmental delay. We conducted multivariate logistic regression analysis to examine the association between maternal psychological distress and children's neurodevelopment. RESULTS: The prevalence of developmental delay of communication, gross motor, fine motor, problem solving and personal-social were 4.0%, 4.3%, 4.9%, 3.8% and 4.6%, respectively. Maternal psychological distress in only the postpartum period and both pre-natal and postpartum periods were associated with risks of developmental delay in all domains. Maternal psychological distress in only the pre-natal period was associated with developmental delay in communication. CONCLUSIONS: Maternal psychological distress is associated with risks of children's developmental delay.

  173. Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children's Study. International-journal

    Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Kaoh Tanoue, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　46　(4)　834-844　2023/02/03

    DOI： 10.1038/s41440-022-01144-3 　

    More details Close

    Hypertensive disorders of pregnancy (HDP) are associated with poor maternal and neonatal prognoses. Although several studies have indicated an effect of secondhand smoke (SHS) exposure on HDP, such evidence is lacking in Japan. Therefore, we analyzed data from the Japan Environment and Children's Study, a large-scale epidemiological investigation, to elucidate a possible link between SHS exposure and HDP risk. Data were obtained from the all-birth fixed datasets and included information on 104,062 fetuses and their parents. SHS exposure was assessed in terms of the frequency (rarely, 1-3, or 4-7 days/week) and the daily duration of exposure (<1, 1-2, or ≥2 h(s)/day). Modified Poisson regression model analyses were performed with adjustment for known risk factors for HDP. Additionally, the population attributable fractions (PAFs) of SHS exposure and maternal smoking to HDP prevalence were estimated. The relative risks of developing HDP among individuals with SHS exposures of 4-7 days/week and ≥2 h/day were 1.18 and 1.27 (95% confidence interval: 1.02-1.36 and 0.96-1.67), respectively, compared to the reference groups (rare exposure and <1 h/day). The PAFs for the risk of HDP due to SHS exposure and perinatal smoking were 3.8% and 1.8%, respectively. Japanese women with greater exposure to SHS have a higher risk of HDP after adjustment for possible confounding factors; thus, relevant measures are required to reduce SHS exposure to alleviate HDP risk. The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4-7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.

  174. 子宮内抗生物質曝露と児の自閉行動の関連に関する検討 東北メディカル・メガバンク計画三世代コホート調査

    阿部 美有, 上野 史彦, 高橋 一平, 大瀬戸 恒志, 石黒 真美, 村上 慶子, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 森下 啓, 小原 拓, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　123-123　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  175. Letter to the Editor: Comment on ‘‘Radiomics with Artificial Intelligence for the Prediction of Early Recurrence in Patients with Clinical Stage IA Lung Cancer’’

    Takuma Usuzaki, Kengo Takahashi, Mami Ishikuro, Taku Obara, Takumi Yamaura, Masahiro Kamimoto, Kazuhiro Majima

    Annals of Surgical Oncology　30　(2)　912-913　2023/02

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1245/s10434-022-12809-1 　

    ISSN： 1068-9265

    eISSN： 1534-4681

  176. 乳幼児期のRSウイルス感染の重症化と喘鳴との関連 東北メディカル・メガバンク計画三世代コホート調査

    上野 史彦, 松崎 芙美子, 中山 慶一, 百瀬 敦, 落合 秀和, 石黒 真美, 村上 慶子, 野田 あおい, 大沼 ともみ, 小原 拓, 菅原 準一, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　136-136　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  177. 妊婦の朝食摂取頻度と児の出生体重との関連 東北メディカル・メガバンク計画三世代コホート調査

    相澤 美里, 村上 慶子, 高橋 一平, 大沼 ともみ, 野田 あおい, 松崎 芙実子, 上野 史彦, 石黒 真美, 小原 拓, 濱田 裕貴, 岩間 憲之, 齋藤 昌利, 菅原 準一, 八重樫 伸生, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　100-100　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  178. 診察室非高血圧者における抑うつ気分と仮面高血圧の関連性の検討

    時岡 紗由理, 中谷 直樹, 千葉 一平, 中谷 久美, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 小原 拓, 栗山 進一, 辻 一郎

    Journal of Epidemiology　33　(Suppl.1)　141-141　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  179. BMI・飲酒・尿Na/K比と高血圧の関連における両親の高血圧既往の影響

    平田 匠, 小暮 真奈, 畑中 里衣子, 千葉 一平, 中谷 久美, 菅野 郁美, 中村 智洋, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 寳澤 篤

    Journal of Epidemiology　33　(Suppl.1)　155-155　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  180. 東北メディカル・メガバンク計画地域住民コホート調査(宮城)詳細二次調査の概要

    中谷 久美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 中村 智洋, 小原 拓, 宇留野 晃, 布施 昇男, 辻 一郎, 栗山 進一, 寳澤 篤

    Journal of Epidemiology　33　(Suppl.1)　173-173　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  181. 生産児での先天異常の有病割合および診断時期 大規模レセプトデータベースを用いた評価

    石川 智史, 川目 裕, 眞野 成康, 小原 拓

    Journal of Epidemiology　33　(Suppl.1)　146-146　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  182. 母親の社会的孤立と児の問題行動の関連 東北メディカル・メガバンク計画三世代コホート調査

    村上 慶子, 石黒 真美, 小原 拓, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 高橋 一平, 菊地 紗耶, 小林 奈津子, 濱田 裕貴, 岩間 憲之, 目時 弘仁, 菊谷 昌浩, 齋藤 昌利, 菅原 準一, 富田 博秋, 八重樫 伸生, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　92-92　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  183. Weight‐for‐age z ‐scores of Japanese children using the World Health Organization Child Growth Standards

    Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

    Acta Paediatrica　112　(4)　776-778　2023/01/17

    Publisher: Wiley

    DOI： 10.1111/apa.16662 　

    ISSN： 0803-5253

    eISSN： 1651-2227

  184. Maternal postnatal bonding disorder and emotional/behavioral problems in preschool children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Aoi Noda, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Journal of affective disorders　325　582-587　2023/01/12

    DOI： 10.1016/j.jad.2023.01.044 　

    More details Close

    BACKGROUND: Although there is some evidence that maternal perinatal mental disorders are associated with emotional/behavioral problems in children, the long-term impacts of postnatal bonding disorder remain unclear. We aimed to examine the associations between maternal postnatal bonding disorder and emotional/behavioral problems in preschool children. METHODS: We analyzed data from 7220 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score ≥5 at 1 month after delivery. The Child Behavior Checklist 1½-5 was used to assess emotional/behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations of postnatal bonding disorder with emotional/behavioral, internalizing, and externalizing problems after adjustment for age, education, income, parity, prenatal psychological distress, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. RESULTS: The prevalence of postnatal bonding disorder was 14.8 %. Postnatal bonding disorder was associated with an increased risk of emotional/behavioral problems in children: the odds ratio (OR) was 2.06 (95 % confidence interval [CI], 1.72-2.46). Postnatal bonding disorder was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.69 (95 % CI, 1.42-2.02) and 1.90 (95 % CI, 1.59-2.26), respectively. LIMITATIONS: Bonding and problems were self-reported. CONCLUSIONS: Bonding disorder at 1 month after delivery was associated with an increased risk of emotional/behavioral problems in children at 4 years of age.

  185. Risk of major congenital malformations associated with first-trimester antihypertensives, including amlodipine and methyldopa: A large claims database study 2010-2019. International-journal

    Tomofumi Ishikawa, Hidekazu Nishigori, Manabu Akazawa, Keiko Miyakoda, Aoi Noda, Mami Ishikuro, Hirohito Metoki, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

    Pregnancy hypertension　31　73-83　2023/01/09

    DOI： 10.1016/j.preghy.2023.01.001 　

    More details Close

    OBJECTIVES: To evaluate the major congenital malformation (MCM) risk of first-trimester antihypertensive exposure, specifically of amlodipine and methyldopa. STUDY DESIGN: A large administrative claims database was used. MAIN OUTCOME MEASURES: The prevalence of antihypertensive prescriptions during pregnancy was described in 91,390 women giving birth between 2010 and 2019. The MCM risk of first-trimester antihypertensives was evaluated in 1,185 women diagnosed with hypertensive disorders in the first trimester. The MCM risk of first-trimester amlodipine and methyldopa was evaluated in 178 women who were prescribed antihypertensives in the first trimester. RESULTS: Antihypertensives were prescribed to 278 (0.30%) women during their first trimester. The prescription prevalence in the first trimester was highest for methyldopa (115, 0.13%), followed by amlodipine (55, 0.06%). Antihypertensives were prescribed to 2,955 (3.23%) women during pregnancy. Nifedipine (903, 0.99%) and nicardipine (758, 0.83%) were the most frequently prescribed oral and injectable antihypertensives during pregnancy, both with a significant increase in annual prevalence. Of the 1,185 women diagnosed with hypertensive disorders in the first trimester, antihypertensives were prescribed to 178 women. The adjusted odds ratio (aOR) of MCMs in the first-trimester prescription of any antihypertensive medication was 1.124 (95% confidence interval [CI], 0.618-2.045). Amlodipine and methyldopa were prescribed to 44 and 93 of the 178 women, respectively. The aORs of MCMs in the first-trimester prescription of amlodipine and methyldopa were 1.219 (95% CI, 0.400-3.721) and 0.921 (0.331-2.564), respectively. CONCLUSIONS: The MCM risk of first-trimester exposure to antihypertensives, including amlodipine and methyldopa, was not suggested.

  186. Birth Outcomes of Anticancer Drug Prescriptions during Pregnancy: A Case Series from a Japanese Claims Database

    Kentaro Tajima, Tomofumi Ishikawa, Masami Tsuchiya, Masafumi Kikuchi, Taku Obara, Nariyasu Mano

    Pharmacoepidemiology　2023/01/06

    DOI： 10.3390/pharma2010002 　

  187. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. International-journal

    Satoko Suzuki, Taku Obara, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Ryutaro Arita, Minoru Ohsawa, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

    Frontiers in pharmacology　14　1107494-1107494　2023

    DOI： 10.3389/fphar.2023.1107494 　

    More details Close

    Traditional Japanese (Kampo) medicines containing rhubarb rhizome are prescribed for constipation during pregnancy; however, detailed safety information of their use for pregnant women is lacking. The aim of current study was to clarify the association between prescription Kampo-containing rhubarb rhizome (KRR) in the first trimester of pregnancy and congenital malformations in newborns. Using a large Japanese health insurance claims database, we included pregnant women who enrolled the same health insurance society from 3 months before pregnancy to the delivery date, who gave birth between 2010 and 2019, and those with data related to their infants. Pregnant women who were prescribed magnesium oxide (MgO), commonly used for constipation, during the first trimester of pregnancy and their infants were extracted as controls. Associations between KRR prescribed in the first pregnancy trimester and major congenital malformations (MCM) in the infants were examined using multivariate logistic regression analysis. Of 75,398 infants, 4,607 (6.1%) were diagnosed with MCMs within the first year after birth. Furthermore, 9,852 infants were born to women prescribed MgO, among whom 680 (6.9%) had MCMs; 450 infants were born to women prescribed KRR, among whom 28 (6.2%) had MCMs. Multivariate logistic regression analysis identified no difference in MCM risk between the two types of prescriptions [crude odds ratio (OR) 0.895, 95% confidence interval (CI) 0.606-1.322, adjusted OR 0.889, 95% CI 0.599-1.320]. In conclusion, the risk of MCMs did not differ between those prescribed KRR or MgO in the first trimester of pregnancy.

  188. Dietary calcium intake was related to the onset of pre-eclampsia: The TMM BirThree Cohort Study. International-journal

    Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, Tomomi Onuma, Aoi Noda, Ippei Takahashi, Fumiko Matsuzaki, Fumihiko Ueno, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

    Journal of clinical hypertension (Greenwich, Conn.)　25　(1)　61-70　2022/12/28

    DOI： 10.1111/jch.14606 　

    More details Close

    This study aimed to explore the relationship between dietary electrolyte intake and the prevalence of hypertensive disorders of pregnancy (HDP) subtypes. Our analysis included 19 914 pregnant women from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. A food frequency questionnaire was used to estimate dietary calcium, potassium, sodium, and magnesium intakes. HDP was determined based on the medical records during regular antenatal care. Logistic regression analysis assessed the relationship between dietary electrolytes intake quintiles, and HDP subtypes with adjustment for basic characteristics. Dietary electrolyte intakes were applied for the prediction model. Of the cohort, 547 participants delivered with pre-eclampsia (PE), 278 with superimposed PE (SP), and 896 with gestational hypertension (GH). PE was associated with low crude calcium intake (odds ratio of the first quintile [<251 mg/day] to the fifth quintile [>623 mg/day] and 95% confidence interval, 1.31 [1.00-1.70]) and P for trend was .02. SP was not associated with any nutritional intake; however, the combined outcome of PE and SP was related to low crude calcium and potassium and energy-adjusted calcium, potassium, and magnesium intakes (P for trend, .01, .048, .02, .04, and .02, respectively). The same tendency was observed for GH. A prediction model that included crude calcium and potassium intakes performed better than a model without them. In conclusion, low dietary calcium, potassium, and magnesium were associated with higher HDP subtypes prevalence. The prediction model implied that crude calcium and potassium intakes might play a critical role in PE and SP pathogenesis.

  189. Plasma metabolic disturbances during pregnancy and postpartum in women with depression. International-journal Peer-reviewed

    Zhiqian Yu, Naomi Matsukawa, Daisuke Saigusa, Ikuko N Motoike, Chiaki Ono, Yasunobu Okamura, Tomomi Onuma, Yuta Takahashi, Mai Sakai, Hisaaki Kudo, Taku Obara, Keiko Murakami, Matusyuki Shirota, Saya Kikuchi, Natsuko Kobayashi, Yoshie Kikuchi, Junichi Sugawara, Naoko Minegishi, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Seizo Koshiba, Hiroaki Tomita

    iScience　25　(12)　105666-105666　2022/12/22

    DOI： 10.1016/j.isci.2022.105666 　

    More details Close

    Examining plasma metabolic profiling during pregnancy and postpartum could help clinicians understand the risk factors for postpartum depression (PPD) development. This analysis targeted paired plasma metabolites in mid-late gestational and 1 month postpartum periods in women with (n = 209) or without (n = 222) PPD. Gas chromatogram-mass spectrometry was used to analyze plasma metabolites at these two time points. Among the 170 objected plasma metabolites, principal component analysis distinguished pregnancy and postpartum metabolites but failed to discriminate women with and without PPD. Compared to women without PPD, those with PPD exhibited 37 metabolites with disparate changes during pregnancy and the 1-month postpartum period and an enriched citrate cycle. Machine learning and multivariate statistical analysis identified two or three compounds that could be potential biomarkers for PPD prediction during pregnancy. Our findings suggest metabolic disturbances in women with depression and may help to elucidate metabolic processes associated with PPD development.

  190. Antihypertensive drug use during pregnancy in Japan. International-journal

    Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Keiko Murakami, Shinichi Kuriyama

    Hypertension research : official journal of the Japanese Society of Hypertension　46　(2)　548-549　2022/12/02

    DOI： 10.1038/s41440-022-01101-0 　

  191. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project.

    Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Tomomi Onuma, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Akira Uruno, Junichi Sugawara, Kichiya Suzuki, Eiichi N Kodama, Yohei Hamanaka, Naho Tsuchiya, Mana Kogure, Naoki Nakaya, Makiko Taira, Mika Sakurai-Yageta, Toru Tamahara, Junko Kawashima, Maki Goto, Akihito Otsuki, Ritsuko Shimizu, Soichi Ogishima, Hiroaki Hashizume, Fuji Nagami, Tomohiro Nakamura, Atsushi Hozawa, Tadao Kobayashi, Nobuo Fuse, Shinichi Kuriyama, Shigeo Kure, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　259　(2)　93-105　2022/12/01

    DOI： 10.1620/tjem.2022.J103 　

    More details Close

    The Tohoku Medical Megabank Project (TMM) has been conducting a birth and three-generation cohort study (the BirThree Cohort Study). We recruited 73,529 pregnant women and their family members for this cohort study, which included 23,143 newborns and 9,459 of their siblings. We designed and are in the process of conducting three-step health assessments for each newborn at approximately ages of 5, 10 and 16. These health assessments are administered at seven community support centers. Trained genome medical research coordinators conduct physical examinations of and collect biological specimens from each participant. The Sendai Children's Health Square has been established as the headquarters for these child health assessments and is utilized to accumulate knowledge that can facilitate the proper practice of child health assessments. We designed all the relevant health assessments facilities to allow parents and their children to participate in the health assessments concomitantly. Our centers serve as places where child participants and their parents can feel at ease as a result of the implementation of safety measures and child hospitality measures. The TMM BirThree Cohort Study is in the process of conducting strategically detailed health assessments and genome analysis, which can facilitate studies concerning the gene-environment interactions relevant to noncommunicable diseases. Through these operations, our study allows for a significant depth of data to be collected in terms of the number of biospecimens under study and the comprehensiveness of both basic and clinical data alongside relevant family information.

  192. Skipping breakfast during pregnancy and hypertensive disorders of pregnancy in Japanese women: the Tohoku medical megabank project birth and three-generation cohort study. International-journal Peer-reviewed

    Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

    Nutrition journal　21　(1)　71-71　2022/11/17

    DOI： 10.1186/s12937-022-00822-9 　

    More details Close

    BACKGROUND: Hypertensive disorders of pregnancy (HDP) adversely affect the prognosis of mother and child, and the prognosis depends on the subtype of HDP. Skipping breakfast may be associated with increased blood pressure due to disruption of the circadian clock, but the association with the development of HDP has not been studied. The purpose of this study was to examine the association between skipping breakfast and the development of HDP and HDP subtypes in Japanese pregnant women. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 18,839 who answered the required questions were included in the analysis. This study had a cross-sectional design. The breakfast intake frequency from pre-pregnancy to early pregnancy was classified into four groups: daily, 5-6 times per week, 3-4 times per week, and 0-2 times per week. HDP was classified into gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE), and severe preeclampsia (SuPE). Multiple logistic regression analysis and multinomial logistic analysis were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for breakfast intake frequency and development of HDP or HDP subtypes. We performed a stratified analysis based on energy intake. RESULTS: Of the participants, 74.3% consumed breakfast daily, and 11.1% developed HDP. Women who consumed breakfast 0-2 times per week had a higher risk of HDP (OR: 1.33, 95% CI: 1.14-1.56), CH (OR: 1.63, 95% CI: 1.21-2.19), and PE (OR: 1.68, 95% CI: 1.27-2.21) than those who consumed breakfast daily. No association was found between skipping breakfast and the risk of developing GH (OR: 1.26, 95% CI: 0.99-1.61) and SuPE (OR: 0.91, 95% CI: 0.55-1.49). Stratified analysis showed that the risk of developing HDP due to skipping breakfast was highest in the group with the highest daily energy intake. CONCLUSIONS: Skipping breakfast during pre-to early pregnancy is associated with the development of HDP. Further longitudinal studies are required to clarify the causal association between skipping breakfast and HDP.

  193. Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

    Ippei Takahashi, Keiko Murakami, Mika Kobayashi, Saya Kikuchi, Ayaka Igarashi, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama

    BMC psychiatry　22　(1)　693-693　2022/11/11

    DOI： 10.1186/s12888-022-04330-2 　

    More details Close

    BACKGROUND: Childcare facilities are a factor that lowers the established association of mother's postnatal psychiatric symptoms with children's behavioral problems. However, no studies have considered the prenatal psychiatric symptoms yet. This study examined whether the use of childcare facilities moderates the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years. METHODS: The present study was based on the data from 23,130 mother-child pairs participating in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. K6 was used to classify maternal psychological distress in early pregnancy and at two years postpartum into four categories: none in both prenatal and postnatal periods (none), only the prenatal period (prenatal only); only the postnatal period (postnatal only); both prenatal and postnatal periods (both). The children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) aged four years. The clinical range of the externalizing, internalizing, and total problem scales of the CBCL was defined as having behavioral problems. To examine whether availing childcare facilities moderates the association between maternal psychological distress and children's behavioral problems, we conducted a stratified analysis based on the use of childcare facilities or not, at two years of age. The interaction term between maternal psychological distress and use of childcare facilities was included as a covariate in the multivariate logistic regression analysis to confirm the p-value for the interaction. RESULTS: The prevalence of the clinical ranges of externalizing problems, internalizing problems, and clinical range of total problems were 13.7%, 15.4%, and 5.8%, respectively. The association of maternal psychological distress with a high risk of children's behavioral problems was significant; however, the association between prenatal only psychological distress and externalizing problems in the group that did not use childcare facilities was not significant. Interactions between the use of childcare facilities and maternal psychological distress on behavioral problems in children were not significant. CONCLUSIONS: Use of childcare facilities did not moderate the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years.

  194. Actual status of patient information sharing among healthcare delivery facilities: a survey by the third subcommittee, committee on academic research, the Japanese society of hospital pharmacists. International-journal

    Daisuke Kikuchi, Masami Tsuchiya, Shiro Hatakeyama, Yuichi Tasaka, Takeshi Uchikura, Ryohkan Funakoshi, Taku Obara

    Journal of pharmaceutical health care and sciences　8　(1)　30-30　2022/11/04

    DOI： 10.1186/s40780-022-00260-z 　

    More details Close

    BACKGROUND: Information sharing among medical professionals is important for providing quality medical care. The purpose of the present study was to elucidate the actual status of information sharing between hospitals and other healthcare delivery facilities by surveying information sharing among the pharmaceutical departments of Japanese hospitals in 2020 conducted by the Japanese Society of Hospital Pharmacists. METHODS: Responses were received from 3612 (43.6%) of the 8278 target medical institutions between May 2020 and August 2020. RESULTS: The proportions of hospitals that shared information with community pharmacies, other hospitals, and long-term nursing homes were 40.6%, 36.4%, and 27.3%, respectively. While tracing reports were the most common tool used by hospitals for information sharing with community pharmacies (54.3%), drug summaries were used for sharing information with other hospitals and long-term nursing homes (77.4% and 78.0%, respectively). The proportion of hospitals sharing information with community pharmacies and other hospitals showed a tendency to increase as the number of hospital beds increased. No relationship could be established between the number of hospital beds and the proportion of hospitals sharing information with long-term nursing homes. CONCLUSION: Information between hospitals and community pharmacies was shared primarily using tracing reports, whereas information between hospitals and other hospitals and long-term nursing homes was primarily shared via drug summaries.

  195. Similarities in cardiometabolic risk factors among random male-female pairs: a large observational study in Japan. International-journal

    Naoki Nakaya, Kumi Nakaya, Naho Tsuchiya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ikumi Kanno, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Shinichi Kuriyama

    BMC public health　22　(1)　1978-1978　2022/10/28

    DOI： 10.1186/s12889-022-14348-6 　

    More details Close

    BACKGROUND: Previous observational studies have shown similarities in cardiometabolic risk factors between spouses. It is still possible that this result reflects the age similarity of spouses rather than environmental factors of spouses (e.g. cohabitation effect). To clarify the importance of mate cardiometabolic risk factors for similarity of environmental factors, it is necessary to examine whether they are observed in random male-female pairs while maintaining the age of the spousal pairs. This study aimed to determine whether the similarities found between spousal pairs for cardiometabolic risks were also observed between random male-female pairs. METHODS: This cross-sectional study included 5,391 spouse pairs from Japan; data were obtained from a large biobank study. For pairings, women of the same age were randomly shuffled to create new male-female pairs of the same age as that of the original spouse pairs. Similarities in cardiometabolic risk factors between the random male-female pairs were analysed using Pearson's correlation or age-adjusted logistic regression analyses. RESULTS: The mean ages of the men and women were 63.2 and 60.4 years, respectively. Almost all cardiometabolic risk factors similarities were not noted in cardiometabolic risk factors, including the continuous risk factors (anthropometric traits, blood pressure, glycated haemoglobin level, and lipid traits); lifestyle habits (smoking, drinking, and physical activity); or diseases (hypertension, type 2 diabetes mellitus, and metabolic syndrome) between the random male-female pairs. The age-adjusted correlation coefficients ranged from - 0.007 for body mass index to 0.071 for total cholesterol. The age-adjusted odds ratio (95% confidence interval) for current drinkers was 0.94 (0.81 - 1.09); hypertension, 1.07 (0.93 - 1.23); and type 2 diabetes mellitus, 1.08 (0.77 - 1.50). CONCLUSION: In this study, few similarities in cardiometabolic risk factors were noted among the random male-female pairs. As spouse pairs may share environmental factors, intervention strategies targeting lifestyle habits and preventing lifestyle-related diseases may be effective.

  196. Social isolation and insomnia among pregnant women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Sleep health　8　(6)　714-720　2022/10/10

    DOI： 10.1016/j.sleh.2022.08.007 　

    More details Close

    OBJECTIVES: To estimate the prevalence of insomnia and examine the association between social isolation and insomnia among pregnant women. METHODS: This cross-sectional study was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Pregnant women were recruited at obstetric clinics and hospitals in Miyagi Prefecture, Japan. We analyzed 17,586 women who completed the questionnaires and were allowed to transcribe medical records. Insomnia was defined as the Athens Insomnia Scale score of ≥6. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores <12), and its subscales were used to assess marginal family ties and marginal friendship ties. Multiple logistic regression analyses were conducted to examine the association between social isolation and insomnia during pregnancy, adjusting for age, parity, prepregnancy body mass index, feelings toward pregnancy, education, income, work status, morning sickness, and psychological distress. Multiple logistic regression analyses were also conducted for marginal family ties and marginal friendship ties. RESULTS: The prevalence of insomnia in the second trimester was 37.3%. Women who were socially isolated were more likely to have insomnia than women who were socially integrated: the multivariate-adjusted odds ratio (OR) was 1.26 (95% confidence interval [CI], 1.16-1.36). Marginal family ties and marginal friendship ties were also associated with increased risks of insomnia: the multivariate-adjusted ORs were 1.40 (95% CI, 1.25-1.56) and 1.15 (95% CI, 1.07-1.24), respectively. CONCLUSIONS: Social isolation from family and friends was associated with increased risks of insomnia among pregnant women.

  197. 妊娠中の降圧薬使用による血圧管理状況と児のSGAとの関連

    石黒 真美, 小原 拓, 野田 あおい, 上野 史彦, 松崎 芙実子, 大沼 ともみ, 村上 慶子, 菊谷 昌浩, 目時 弘仁, 菅原 準一, 栗山 進一

    DOHaD研究　10　(2)　68-68　2022/10

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  198. 妊婦への大黄含有漢方薬の処方と出生児の先天奇形との関連に関する研究 大規模レセプトデータベースを用いて

    鈴木 聡子, 小原 拓, 石川 智史, 有田 龍太郎, 大澤 稔, 野田 あおい, 松崎 芙実子, 菊地 章子, 高山 真, 眞野 成康, 石井 正

    DOHaD研究　10　(2)　66-66　2022/10

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  199. 東北メディカル・メガバンク計画三世代コホート調査 概要と進捗

    小原 拓, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 中谷 直樹, 寳澤 篤, 菅原 準一, 栗山 進一

    DOHaD研究　10　(2)　80-80　2022/10

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  200. 妊婦に対する抗菌薬処方の実態 レセプトデータベースに基づく検討

    森下 啓, 石川 智史, 小原 竜, 野田 あおい, 松崎 芙実子, 石黒 真美, 眞野 成康, 栗山 進一, 小原 拓

    DOHaD研究　10　(2)　79-79　2022/10

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  201. Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Journal of affective disorders　320　461-467　2022/09/30

    DOI： 10.1016/j.jad.2022.09.139 　

    More details Close

    BACKGROUND: Natural disasters can have serious mental health consequences. We aimed to examine the long-term effects of the 2011 Great East Japan Earthquake (GEJE) on postpartum depressive symptoms (PDS). METHODS: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women in Miyagi Prefecture from 2013 to 2016. Data from 11,403 participants were used in this study. Women were asked about their traumatic experiences of the GEJE with questions addressing threat, witness, and loss. PDS were defined as Edinburgh Postnatal Depression Scale score ≥9 at 1 month after delivery. Multiple logistic regression analyses were conducted to examine the associations of different traumatic experiences of the GEJE and number of traumatic experiences with PDS, after adjustment for age, parity, feelings toward pregnancy, education, income, social isolation, house damage caused by the GEJE, and survey year. RESULTS: About two-fifths of women had at least one traumatic experience of the GEJE. The prevalence of PDS at 1 month after delivery was 13.3 %. Life-threatening experience and witnessing another person's actual or threatened death were associated with PDS: the odds ratios (ORs) were 1.40 (95 % confidence interval [CI], 1.24-1.59) and 1.28 (95 % CI, 1.08-1.53), respectively. Loss of close person was not associated with PDS: the OR was 1.13 (95 % CI, 0.99-1.30). Larger number of traumatic experiences of the GEJE was associated with increased risk of PDS (p for trend <0.001). LIMITATIONS: PDS was self-reported. CONCLUSIONS: Traumatic experiences of the GEJE prior to pregnancy were associated with increased risks of PDS.

  202. Liver steatosis and fibrosis markers' association with cardiovascular and renal damage in Japanese adults: the TMM BirThree cohort study. International-journal

    Toshiya Machida, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Jun Inoue, Shinichi Kuriyama, Nariyasu Mano

    Annals of hepatology　28　(1)　100761-100761　2022/09/27

    DOI： 10.1016/j.aohep.2022.100761 　

    More details Close

    INTRODUCTION AND OBJECTIVES: Patients with non-alcoholic fatty liver disease (NAFLD) are at risk for cardiovascular and chronic kidney diseases. Liver steatosis and fibrosis were assessed using the fatty liver index and fibrosis-4 index, respectively. This study aimed to examine the association between these two parameters in patients with atherosclerosis and chronic kidney disease. METHODS: The two parameters were calculated for 11,867 adults who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Intima-media thickness and estimated glomerular filtration rate were also measured. Logistic regression models were used to estimate the odds ratios (OR). RESULTS: Overall, 4,257 (35.9%) and 4,733 (39.9%) participants had a higher probability of liver steatosis and fibrosis, respectively. The adjusted OR of higher fatty liver index compared to lower fatty liver index for atherosclerosis and chronic kidney disease were 0.98 (95% confidence interval [CI], 0.77-1.24) and 1.79 (95% CI, 1.19-2.69), and those of higher FIB-4 compared to lower FIB-4 were 1.03 (95% CI, 0.82-1.30) and 0.79 (95% CI, 0.52-1.19) for atherosclerosis and chronic kidney disease, respectively. CONCLUSIONS: A higher FLI was associated with CKD independent of other risk factors. Further research is required to identify the causal relationship between liver fat accumulation and CKD.

  203. Social isolation and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Archives of Women's Mental Health　2022/09/17

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00737-022-01266-0 　

    ISSN： 1434-1816

    eISSN： 1435-1102

  204. Dietary patterns before and during pregnancy and small for gestational age in Japan: a prospective birth cohort study

    Takahiro Yamashita, Taku Obara, Yudai Yonezawa, Ippei Takahashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Noriyuki Iwama, Hirotaka Hamada, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Masatoshi Saito, Nobuo Yaegashi, Shinichi Kuriyama

    Nutrition Journal　21　(1)　2022/09/16

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12937-022-00808-7 　

    eISSN： 1475-2891

    More details Close

    Abstract Background Although small for gestational age (SGA) is a serious problem worldwide, the association of dietary patterns before and during pregnancy with SGA risk is unclear. We evaluated this association among Japanese pregnant women using three methods: reduced rank regression (RRR) and partial least squares (PLS), methods for extracting dietary patterns that can explain the variation of response variables, and principal component analysis (PCA), a method for extracting dietary patterns of the population. Methods Between July 2013 and March 2017, 22,493 pregnant women were recruited to the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a population-based prospective birth cohort study in Japan. Information on dietary intake was obtained using food frequency questionnaires, and dietary patterns were extracted using RRR, PLS, and PCA. Information on birth weight was obtained from obstetric records, and the birth weight SD score and SGA were defined by the method of the Japan Pediatric Society. The associations of dietary patterns with birth weight SD score and SGA risk were investigated using multiple linear regression and multiple logistic regression, respectively. Results A total of 17,728 mother-child pairs were included. The birth weight SD score was 0.15 ± 0.96, and the prevalence of SGA was 6.3%. The dietary patterns extracted by RRR and PLS were similar and characterized by a high intake of cereals and fruits and a low intake of alcoholic and non-alcoholic beverages in both pre- to early pregnancy and from early to mid-pregnancy. Higher adoption of the RRR and PLS patterns in both periods was associated with an increased birth weight SD score and lower risk of SGA. In contrast, the PCA1 pattern was not associated with birth weight SD score or SGA risk in either period. Although the PCA2 pattern was associated with increased birth weight SD score from early to mid-pregnancy, no other associations with birth weight SD score or SGA risk were observed. Conclusions The dietary pattern with a high intake of cereals and fruits and a low intake of alcoholic and non-alcoholic beverages before and during pregnancy was associated with a decreased SGA risk in Japan.

  205. 東日本大震災による自宅の被害状況と高血圧治療中断との関連

    畑中 里衣子, 中谷 直樹, 小暮 真奈, 中谷 久美, 千葉 一平, 菅野 郁美, 中村 智洋, 後岡 広太郎, 小原 拓, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　196-196　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  206. 過敏性腸症候群の有病に関連する要因の検討 TMM計画地域住民コホート調査

    中谷 久美, 中谷 直樹, 永家 聖, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 金澤 素, 荻島 創一, 栗山 進一, 辻 一郎, 寳澤 篤, 福土 審

    日本公衆衛生学会総会抄録集　81回　201-201　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  207. Prescription trends in anti-seizure medications for adult patients with epilepsy in Japan: A retrospective cohort study using the database of health insurance claims between 2015 and 2019

    Kazutaka Jin, Taku Obara, Kyoko Hirano, Daichi Hirai, Masatoshi Kiuchi, Takeshi Tanaka, Nobukazu Nakasato

    Epilepsy and Behavior　134　2022/09

    DOI： 10.1016/j.yebeh.2022.108841 　

    ISSN： 1525-5050

    eISSN： 1525-5069

  208. Pharmacists' knowledge of automated blood pressure devices. International-journal

    Aoi Noda, Taku Obara, Yutaka Imai

    Journal of human hypertension　2022/08/26

    DOI： 10.1038/s41371-022-00746-1 　

  209. Effectiveness of Influenza Vaccination among Children in Satellite Cities of a Metropolitan Area in Tokyo, Japan during the 2014/2015-2018/2019 Season.

    Ayako Matsuda, Kei Asayama, Taku Obara, Naoto Yagi, Takayoshi Ohkubo

    The Tohoku journal of experimental medicine　258　(1)　69-78　2022/08/18

    DOI： 10.1620/tjem.2022.J057 　

    More details Close

    Influenza vaccination is recommended for children. In particular, those aged 6 months to 12 years were recommended two vaccinations in Japan, whereas the recommended year range for the twice vaccination is 6 months to 8 years by the World Health Organization (WHO). This study assessed the effectiveness of influenza vaccination and whether the twice vaccinations enhanced preventive effects against influenza infection among children living in two satellite cities of a metropolitan area in Tokyo, Japan. During the influenza season of 2014-2018, parents of all preschool, elementary school, and junior high school children participated in an annual survey. Adjusted odds ratios (AOR) with 95% confidence intervals (CIs) were calculated via multivariate logistic regression analysis to evaluate influenza vaccination effectiveness and trends in the number of vaccinations. Among the 108,362 children who received the research questionnaire, 76,753 (70.8%) responded. After excluding responses without basic information, 64,586 children were included in the analysis. Vaccination was more effective in preschool and lower grade elementary school children given the increase in the number of vaccinations (test for trend: P < 0.001). The AOR of influenza for pre, grade 1 elementary, and grade 2 schoolchildren who received two vaccinations was 0.63 (95% CI, 0.59-0.69), 0.75 (0.67-0.83), and 0.81 (0.71-0.92), respectively, when compared to those without vaccination. However, no trend in vaccinations and their effectiveness was observed in the third and higher-grade school children. Our findings support the recommendation by the WHO, and could help guide influenza vaccination policies for children in Japan.

  210. Actual impact of angiotensin II receptor blocker or calcium channel blocker monotherapy on renal function in real-world patients. International-journal

    Michihiro Satoh, Takuo Hirose, Hironori Satoh, Shingo Nakayama, Taku Obara, Takahisa Murakami, Tomoko Muroya, Kei Asayama, Masahiro Kikuya, Takefumi Mori, Yutaka Imai, Takayoshi Ohkubo, Hirohito Metoki

    Journal of hypertension　40　(8)　1564-1576　2022/08/01

    DOI： 10.1097/HJH.0000000000003186 　

    More details Close

    OBJECTIVE: This observational retrospective cohort study investigates the effect of antihypertensive therapy with angiotensin II receptor blockers (ARBs) or dihydropyridine calcium channel blockers (dCCBs) monotherapy on renal function using longitudinal real-world health data of a drug-naive, hypertensive population without kidney disease. METHODS: Using propensity score matching, we selected untreated hypertensive participants ( n  = 10 151) and dCCB ( n  = 5078) or ARB ( n  = 5073) new-users based on annual health check-ups and claims between 2008 and 2020. Participants were divided by the first prescribed drug. RESULTS: The mean age was 51 years, 79% were men and the mean estimated glomerular filtration rate (eGFR) was 78 ml/min per 1.73 m 2 . Blood pressure rapidly decreased by approximately 10% in both treatment groups. At the 1-year visit, eGFR levels decreased in the ARB group by nearly 2% but increased in the dCCB group by less than 1%. However, no significant difference was apparent in the annual eGFR change after the 1-year visit. The risk for composite kidney outcome (new-onset proteinuria or eGFR decline ≥30%) was lowest in the ARB group owing to their robust effect on preventing proteinuria: hazard ratio (95% confidence interval) for proteinuria was 0.91 (0.78-1.05) for the dCCB group and 0.54 (0.44-0.65) for the ARB group, compared with that for the untreated group after ending follow-up at the last visit before changing antihypertensive treatment. CONCLUSION: From the present findings based on the real-world data, ARBs can be recommended for kidney protection even in a primary care setting. Meanwhile, dCCB treatment initially increases eGFR with no adverse effects on proteinuria.

  211. Deep embedded clustering by relevant scales and genome-wide association study in autism

    Fumihiko Ueno, Tomomi Onuma, Ippei Takahashi, Hisashi Ohseto, Akira Narita, Taku Obara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumiko Matsuzaki, Hirohito Metoki, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama

    2022/07/25

    DOI： 10.1101/2022.07.25.500917 　

  212. Prescription trends in anti-seizure medications for adult patients with epilepsy in Japan: A retrospective cohort study using the database of health insurance claims between 2015 and 2019. International-journal

    Kazutaka Jin, Taku Obara, Kyoko Hirano, Daichi Hirai, Masatoshi Kiuchi, Takeshi Tanaka, Nobukazu Nakasato

    Epilepsy & behavior : E&B　134　108841-108841　2022/07/25

    DOI： 10.1016/j.yebeh.2022.108841 　

    More details Close

    OBJECTIVE: To investigate whether newer anti-seizure medications (ASMs) are widely prescribed for a range of adult patients in Japan, including patients with previously and newly diagnosed epilepsy, or with focal and generalized epilepsies. METHODS: A retrospective cohort study was conducted using the Japanese insurance claims database including 8.4 million people to identify adults (≥16 years of age) with epilepsy diagnosis code identified between January 2015 and December 2018. Patients were included in the prevalent population if epilepsy was already diagnosed at baseline, and in the incident population if prior baseline data for at least 12 months included no epilepsy diagnosis code or ASM prescription. Patients were followed up from the month when the initial oral ASM was prescribed for up to 4 years until the end of 2019 as long as at least one ASM was prescribed. Proportions of prescribed oral ASMs were analyzed by population with epilepsy (prevalent vs. incident) and classification (focal vs. generalized). Anti-seizure medications were classified into older vs. newer ASMs according to the date of approval before and after 1990, respectively. RESULTS: A total of 24,691 patients fulfilled the eligibility criteria for the analysis. Of these, 21,046 and 3,645 were included in the prevalent and incident populations, respectively. The proportion of older ASMs significantly decreased, whereas the proportion of newer ASMs significantly increased (p < 0.0001) during the study period. This trend was more apparent in the population with incident epilepsy than in that with prevalent epilepsy, and was also apparent in the subgroup of focal epilepsy, but not in that of generalized epilepsy. Levetiracetam was the most frequently prescribed of the newer ASMs. CONCLUSION: Newer ASMs became more widely prescribed throughout the study period in populations with both prevalent and incident epilepsies, as well as the subpopulation with focal epilepsy. The advantages of newer ASMs such as better safety profiles may have led to the increasing proportions of prescriptions and newer ASMs may increase the treatment options for patients.

  213. Validation of the Mother-to-Infant Bonding Scale for Infant Maltreatment by Mothers at One Month Postpartum: An Adjunct Study of the Japan Environment and Children's Study.

    Toshie Nishigori, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Miyuki Mori, Taeko Suzuki, Mami Ishikuro, Nozomi Tatsuta, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi, Hidekazu Nishigori

    JMA journal　5　(3)　366-369　2022/07/15

    DOI： 10.31662/jmaj.2022-0041 　

  214. Development and validation of claims-based algorithms to identify pregnancy based on data from a university hospital in Japan. International-journal

    Kentaro Tajima, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Kei Morishita, Ryusuke Inoue, Noriyuki Iwama, Hidekazu Nishigori, Junichi Sugawara, Masatoshi Saito, Taku Obara, Nariyasu Mano

    Current medical research and opinion　38　(9)　1-8　2022/07/14

    DOI： 10.1080/03007995.2022.2101817 　

    More details Close

    OBJECTIVE: When using administrative data, validation is essential since these data are not collected for research purposes and misclassification can occur. Thus, this study aimed to develop algorithms identifying pregnancy and to evaluate the validity of administrative claims data in Japan. METHODS: All females who visited the Tohoku University Hospital Department of Obstetrics in 2018 were included. The diagnosis, medical procedure, medication, and medical service addition fee data were utilized to identify pregnancy, with the electronic medical records set as the gold standard. Combination algorithms were developed using predefined pregnancy-related claims data with a positive predictive value (PPV) ≥80%. Sensitivity (SE), specificity (SP), PPV, and negative predictive value (NPV) with their corresponding 95% confidence intervals (CIs) were calculated for these combination algorithms. RESULTS: This study included 1,757 females with a mean age of 32.8 (standard deviation: 5.9) years. In general, the individual claims data were able to identify pregnancy with a PPV ≥80%; however, the number of pregnancies identified using a single claims data was limited. Based on the combination algorithm with all of the categories, including diagnosis, medical procedure, medication, and medical service addition, the calculated SE, SP, PPV, and NPV were 73.4% (95% CI: 71.2%-75.4%), 96.9% (95% CI: 89.3%-99.6%), 99.8%,(95% CI: 99.4%-100.0%), and 12.3% (95% CI: 9.6%-15.4%), respectively. CONCLUSIONS: The combination algorithm to identify pregnancy demonstrated a high PPV and moderate SE. The algorithm validated in this study is expected to accelerate future studies that aim to identify pregnancies and evaluate pregnancy outcome.

  215. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 寳澤 篤

    東北公衆衛生学会誌　(71)　28-28　2022/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  216. Time-series analysis of blood pressure changes after the guideline update in 2019 and the coronavirus disease pandemic in 2020 using Japanese longitudinal data. International-journal

    Michihiro Satoh, Takahisa Murakami, Taku Obara, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　45　(9)　1408-1417　2022/06/20

    DOI： 10.1038/s41440-022-00961-w 　

    More details Close

    We assessed blood pressure (BP) changes during fiscal years (April to March of the following year) 2015-2020 to clarify the effect of the state of emergency due to the coronavirus disease 2019 (COVID-19) pandemic in 2020. We then considered BP in 2019 separately, as the Japanese hypertension guidelines were updated in 2019. The present retrospective cohort study extracted data from 157,510 Japanese individuals aged <75 years (mean age: 50.3 years, men: 67.5%) from the annual health check-up data of the DeSC database. The trends in BP were assessed using a repeated measures linear mixed model. After adjusting for the month of health check-ups to exclude seasonal BP variation, systolic BP linearly increased during fiscal years 2015-2018. From the value estimated by the trend in 2015-2018, systolic BP was lower by ≤1 mmHg in fiscal year 2019 among the treated participants. Meanwhile, systolic/diastolic BP (95% confidence interval) increased by 2.11 (1.97-2.24)/1.05 (0.96-1.14) mmHg for untreated women (n = 43,292), 1.60 (1.51-1.70)/1.17 (1.11-1.24) mmHg for untreated men (n = 88,479), 1.92 (1.60-2.23)/0.46 (0.25-0.67) mmHg for treated women (n = 7855), and 1.00 (0.79-1.21)/0.39 (0.25-0.53) mmHg for treated men (n = 17,884) in fiscal year 2020. These increases remained time-dependent covariates after adjustments for age, body mass index, alcohol consumption, smoking, physical activity, and blood sampling indices. Social change due to the pandemic might have increased BP by approximately 1-2/0.5-1 mmHg. Meanwhile, only a slight decrease in BP was observed immediately after the guideline update in Japan.

  217. Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement. International-journal

    Hirohito Metoki, Noriyuki Iwama, Hirotaka Hamada, Michihiro Satoh, Takahisa Murakami, Mami Ishikuro, Taku Obara

    Hypertension research : official journal of the Japanese Society of Hypertension　45　(8)　1298-1309　2022/06/20

    DOI： 10.1038/s41440-022-00965-6 　

    More details Close

    Hypertensive disorders of pregnancy increase the risk of adverse maternal and fetal outcomes. In 2018, the Japanese classification of hypertensive disorders of pregnancy was standardized with those of other countries, and a hypertensive disorder of pregnancy was considered to be present if hypertension existed during pregnancy and up to 12 weeks after delivery. Strategies for the prevention of hypertensive disorders of pregnancy have become much clearer, but further research is needed on appropriate subjects and methods of administration, and these have not been clarified in Japan. Although guidelines for the use of antihypertensive drugs are also being studied and standardized with those of other countries, the use of calcium antagonists before 20 weeks of gestation is still contraindicated in Japan because of the safety concerns that were raised regarding possible fetal anomalies associated with their use at the time of their market launch. Chronic hypertension is now included in the definition of hypertensive disorders of pregnancy, and blood pressure measurement is a fundamental component of the diagnosis of hypertensive disorders of pregnancy. Out-of-office blood pressure measurements, including ambulatory and home blood pressure measurements, are important for pregnant and nonpregnant women. Although conditions such as white-coat hypertension and masked hypertension have been reported, determining their occurrence in pregnancy is complicated by the gestational week. This narrative review focused on recent reports on hypertensive disorders of pregnancy, including those related to blood pressure measurement and classification.

  218. Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan

    Daisuke Kikuchi, Taku Obara, Ryosuke Miura, Naoto Suzuki, Hiroyuki Hirakawa, Risa Josaka, Misato Ito, Misaki Tokunaga, Kensuke Usui, Kouji Okada

    Hypertension Research　2022/06/17

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-022-00956-7 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  219. Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. International-journal

    Aoi Noda, Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Zen Watanabe, Naomi Shiga, Noriyuki Iwama, Hamada Hirotaka, Tatsui Otsuka, Masahito Tachibana, Hiroaki Tomita, Masatoshi Saito, Junichi Sugawara, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

    BMJ open　12　(6)　e060944　2022/06/07

    DOI： 10.1136/bmjopen-2022-060944 　

    More details Close

    OBJECTIVES: This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: The study population consisted of mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire. OUTCOME MEASURES: The children's neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. We performed a multivariate logistic regression analysis of the association between infertility treatment (including ovulation induction (OI), artificial insemination with husband's sperm (AIH) and assisted reproductive technology (ART)) and the clinical range of ASQ-3. RESULTS: Of 9655 mother-child pairs, 273 (2.8%) and 487 (5.0%) were conceived through OI/AIH and ART, respectively. The odds of having developmental delays at 2 years of age were higher in children conceived through OI/AIH (OR, 1.36; 95% CI 1.00 to 1.85) and ART (OR, 1.36; 95% CI 1.07 to 1.72) than in those conceived naturally. Additionally, OI/AIH and ART were significantly associated with communication (OR, 1.93; 95% CI 1.25 to 2.98) and gross motor (OR, 1.50; 95% CI 1.08 to 2.09) delays, respectively. There were no statistically significant differences in the odds of having developmental delays at 3.5 years of age in children conceived through OI/AIH (OR, 1.13; 95% CI 0.79 to 1.61) and ART (OR, 1.03; 95% CI 0.78 to 1.37). CONCLUSION: In this study, we found a significant association between infertility treatment and children's neurodevelopment at 2 years of age, whereas no statistically significant differences were found at 3.5 years of age.

  220. 健診とレセプトを組合せたデータに基づくAng II受容体拮抗薬と腎機能の関連

    佐藤 倫広, 廣瀬 卓男, 佐藤 弘典, 村上 任尚, 小原 拓, 中山 晋吾, 室谷 智子, 森 建文, 今井 潤, 大久保 孝義, 目時 弘仁

    日本医薬品情報学会総会・学術大会講演要旨集　24回　101-101　2022/06

    Publisher: (一社)日本医薬品情報学会

  221. 妊娠初期の消化管運動改善薬の大奇形リスク 大規模レセプトデータベースを用いた評価

    石川 智史, 小原 拓, 赤沢 学, 野田 あおい, 大柳 元, 都田 桂子, 西郡 秀和, 川目 裕, 八重樫 伸生, 栗山 進一, 眞野 成康

    日本医薬品情報学会総会・学術大会講演要旨集　24回　98-98　2022/06

    Publisher: (一社)日本医薬品情報学会

  222. 2010-2019年の妊婦に対する降圧薬処方状況 大規模レセプトデータベースを用いた評価

    石川 智史, 西郡 秀和, 赤沢 学, 都田 桂子, 野田 あおい, 石黒 真美, 目時 弘仁, 八重樫 伸生, 栗山 進一, 眞野 成康, 小原 拓

    日本医薬品情報学会総会・学術大会講演要旨集　24回　99-99　2022/06

    Publisher: (一社)日本医薬品情報学会

  223. 周産期におけるカルシニューリン阻害薬の処方状況と出生児に対する安全性の評価

    八島 一史, 野田 あおい, 石川 智史, 松崎 芙実子, 都田 桂子, 西郡 秀和, 眞野 成康, 小原 拓

    日本医薬品情報学会総会・学術大会講演要旨集　24回　100-100　2022/06

    Publisher: (一社)日本医薬品情報学会

  224. 妊婦に対する抗精神病薬処方の実態 レセプトデータベースに基づく検討

    小原 竜, 石川 智史, 森下 啓, 野田 あおい, 松崎 芙実子, 石黒 真美, 栗山 進一, 小原 拓

    日本医薬品情報学会総会・学術大会講演要旨集　24回　108-108　2022/06

    Publisher: (一社)日本医薬品情報学会

  225. 【早期に見極め すばやく対応!重篤副作用の予防と治療】副作用報告を実践しよう 副作用報告の質向上を目指して

    小原 拓, 土屋 雅美, 眞野 成康

    薬事　64　(8)　1609-1613　2022/06

    Publisher: (株)じほう

    ISSN： 0016-5980

  226. イトラコナゾール錠へのリルマザホン混入事例 JADERを用いた解析

    土屋 雅美, 小原 拓, 眞野 成康

    日本医薬品情報学会総会・学術大会講演要旨集　24回　99-99　2022/06

    Publisher: (一社)日本医薬品情報学会

  227. レセプトデータベースを用いた妊娠中のがん薬物療法および出産転帰の調査

    田島 健太郎, 土屋 雅美, 石川 智史, 小原 拓, 眞野 成康

    日本医薬品情報学会総会・学術大会講演要旨集　24回　104-104　2022/06

    Publisher: (一社)日本医薬品情報学会

  228. 【早期に見極め すばやく対応!重篤副作用の予防と治療】副作用報告を実践しよう 副作用報告の質向上を目指して

    小原 拓, 土屋 雅美, 眞野 成康

    薬事　64　(8)　1609-1613　2022/06

    Publisher: (株)じほう

    ISSN： 0016-5980

  229. Response to “Scaling up monitoring of risk minimization measures in women of childbearing age with anti-seizure medicines”

    Daisuke Kikuchi, Taku Obara, Ryosuke Miura, Naoto Suzuki, Risa Josaka, Misaki Tokunaga, Ryusuke Ouchi, Kensuke Usui, Kouji Okada

    Seizure　2022/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.seizure.2022.06.014 　

    ISSN： 1059-1311

  230. Risk scores for predicting small for gestational age infants in Japan: The TMM birthree cohort study. International-journal

    Noriyuki Iwama, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Tetsuro Hoshiai, Masatoshi Saito, Hirohito Metoki, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

    Scientific reports　12　(1)　8921-8921　2022/05/26

    DOI： 10.1038/s41598-022-12892-0 　

    More details Close

    This study aimed to construct a prediction model for small-for-gestational-age (SGA) infants in Japan by creating a risk score during pregnancy. A total of 17,073 subjects were included in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study. A multiple logistic regression model was used to construct risk scores during early and mid-gestational periods (11-17 and 18-21 weeks of gestation, respectively). The risk score during early gestation comprised the maternal age, height, body mass index (BMI) during early gestation, parity, assisted reproductive technology (ART) with frozen-thawed embryo transfer (FET), smoking status, blood pressure (BP) during early gestation, and maternal birth weight. The risk score during mid-gestation also consisted of the maternal age, height, BMI during mid-gestation, weight gain, parity, ART with FET, smoking status, BP level during mid-gestation, maternal birth weight, and estimated fetal weight during mid-gestation. The C-statistics of the risk scores during early- and mid-gestation were 0.658 (95% confidence interval [CI]: 0.642-0.675) and 0.725 (95% CI: 0.710-0.740), respectively. In conclusion, the predictive ability of the risk scores during mid-gestation for SGA infants was acceptable and better than that of the risk score during early gestation.

  231. Itraconazole Contaminated with Rilmazafone in Japan: A Retrospective Analysis Using the Japanese Adverse Drug Event Report Database. International-journal

    Masami Tsuchiya, Taku Obara, Nariyasu Mano

    Drugs - real world outcomes　9　(3)　315-319　2022/05/23

    DOI： 10.1007/s40801-022-00306-6 　

    More details Close

    BACKGROUND: In early December 2020, the antifungal medication, itraconazole (ITCZ), was mistakenly contaminated with rilmazafone in Japan. Healthcare professionals reported adverse drug reaction reports associated with ITCZ and included central nervous system-depression symptoms such as dizziness, lightheadedness, loss of consciousness, and intense drowsiness. OBJECTIVE: We examined ITCZ-associated suspicious cases using the Japanese Adverse Drug Event Report (JADER) database to determine the impact of adverse drug reaction reporting on post-marketing safety measures. METHODS: Adverse drug reaction reports in which the suspicious or concomitant medication was ITCZ or fluconazole (FLCZ) were extracted from the JADER dataset. The number of adverse drug reaction reports associated with central nervous system-depression adverse drug reactions were counted, and chronological changes were compared with ITCZ and FLCZ. RESULTS: Of the 713,893 adverse drug reaction reports in the JADER database, 5048 cases were associated with ITCZ and 6007 cases with FLCZ. When ITCZ contamination occurred, the number of adverse drug reaction reports associated with ITCZ increased rapidly, while those with FLCZ did not. In addition, the proportion of central nervous system-depression adverse drug reactions increased only in the ITCZ-associated report. CONCLUSIONS: An incident of ITCZ contamination with rilmazafone was detected on the JADER retrospectively. This case highlights the importance of spontaneous adverse drug reaction reporting, even if the causal relationship between the drug and adverse drug reaction is unknown.

  232. Validity of Administrative Data for Identifying Birth-Related Outcomes with the End Date of Pregnancy in a Japanese University Hospital. International-journal

    Kentaro Tajima, Tomofumi Ishikawa, Fumiko Matsuzaki, Aoi Noda, Kei Morishita, Ryusuke Inoue, Noriyuki Iwama, Hidekazu Nishigori, Junichi Sugawara, Masatoshi Saito, Taku Obara, Nariyasu Mano

    International journal of environmental research and public health　19　(8)　2022/04/16

    DOI： 10.3390/ijerph19084864 　

    More details Close

    This study aimed to develop and validate claims-based algorithms for identifying live birth, fetal death, and cesarean section by utilizing administrative data from a university hospital in Japan. We included women who visited the Department of Obstetrics at a university hospital in 2018. The diagnosis, medical procedures, and medication data were used to identify potential cases of live birth, fetal death, and cesarean section. By reviewing electronic medical records, we evaluated the positive predictive values (PPVs) and the accuracy of the end date of pregnancy for each claims datum. "Selected algorithm 1" based on PPVs and "selected algorithm 2" based on both the PPVs and the accuracy of the end date of pregnancy were developed. A total of 1757 women were included, and the mean age was 32.8 years. The PPVs of "selected algorithm 1" and "selected algorithm 2" were both 98.1% for live birth, 99.0% and 98.9% for fetal death, and 99.7% and 100.0% for cesarean section, respectively. These findings suggest that the developed algorithms are useful for future studies for evaluating live birth, fetal death, and cesarean section with an accurate end date of pregnancy.

  233. Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Scientific reports　12　(1)　6400-6400　2022/04/16

    DOI： 10.1038/s41598-022-09944-w 　

    More details Close

    Personality has been shown to predict postpartum depressive symptoms (PDS) assessed by the Edinburgh Postnatal Depression Scale (EPDS). However, existing studies have not considered the underlying symptom dimensions in the EPDS. We analyzed data from 15,012 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised. PDS were defined as EPDS score ≥ 9 at 1 month after delivery. The EPDS items were further divided into three dimensions: depressed mood, anxiety, and anhedonia. Multiple analyses were conducted to examine the associations of each personality scale with PDS and three dimensions in the EPDS, adjusting for age, parity, mode of delivery, education, income, and social isolation. The prevalence of PDS assessed by the EPDS at 1 month after delivery was 13.1%. Higher neuroticism scores were associated with PDS (odds ratio [OR], 2.63; 95% confidence interval [CI], 2.48 to 2.79) and all three dimensions (all p < 0.001). Lower extraversion scores were associated with PDS (OR, 0.74; 95% CI, 0.70 to 0.78) and all three dimensions (all p < 0.001). Lower psychoticism scores were associated with PDS (OR, 0.89; 95% CI, 0.85 to 0.94) and anxiety (p < 0.001), but not with depressed mood (p = 0.20) or anhedonia (p = 0.92). In conclusion, higher neuroticism and lower extraversion were associated with PDS and the three underlying dimensions in the EPDS, while lower psychoticism was associated with anxiety, but not with depressed mood or anhedonia.

  234. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. Peer-reviewed

    Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, Yoichi Suzuki, Kichiya Suzuki, Akira Uruno, Mika Sakurai-Yageta, Yohei Hamanaka, Makiko Taira, Soichi Ogishima, Shinichi Kuriyama, Atsushi Hozawa, Hiroaki Tomita, Naoko Minegishi, Junichi Sugawara, Inaho Danjoh, Tomohiro Nakamura, Tomoko Kobayashi, Yumi Yamaguchi-Kabata, Shu Tadaka, Taku Obara, Eiji Hishimuma, Nariyasu Mano, Masaki Matsuura, Yuji Sato, Masateru Nakasone, Yohei Honkura, Jun Suzuki, Yukio Katori, Yoichi Kakuta, Atsushi Masamune, Yoko Aoki, Masaharu Nakayama, Shigeo Kure, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto

    JMA journal　5　(2)　177-189　2022/04/15

    DOI： 10.31662/jmaj.2021-0156 　

    More details Close

    Introduction: Pharmacogenomic (PGx) testing results provide valuable information on drug selection and appropriate dosing, maximization of efficacy, and minimization of adverse effects. Although the number of large-scale, next-generation-sequencing-based PGx studies has recently increased, little is known about the risks and benefits of returning PGx results to ostensibly healthy individuals in research settings. Methods: Single-nucleotide variants of three actionable PGx genes, namely, MT-RNR1, CYP2C19, and NUDT15, were returned to 161 participants in a population-based Tohoku Medical Megabank project. Informed consent was obtained from the participants after a seminar on the outline of this study. The results were sent by mail alongside sealed information letter intended for clinicians. As an exception, genetic counseling was performed for the MT-RNR1 m.1555A > G variant carriers by a medical geneticist, and consultation with an otolaryngologist was encouraged. Questionnaire surveys (QSs) were conducted five times to evaluate the participants' understanding of the topic, psychological impact, and attitude toward the study. Results: Whereas the majority of participants were unfamiliar with the term PGx, and none had undergone PGx testing before the study, more than 80% of the participants felt that they could acquire basic PGx knowledge sufficient to understand their genomic results and were satisfied with their potential benefit and use in future prescriptions. On the other hand, some felt that the PGx concepts or terminology was difficult to fully understand and suggested that in-person return of the results was desirable. Conclusions: These results collectively suggest possible benefits of returning preemptive PGx information to ostensibly healthy cohort participants in a research setting.

  235. Trends in the prescription of anti-seizure medicines for pregnant women outpatients with epilepsy during 2016–2020 in Japan

    Daisuke Kikuchi, Taku Obara, Ryosuke Miura, Naoto Suzuki, Risa Josaka, Misaki Tokunaga, Ryusuke Ouchi, Kensuke Usui, Kouji Okada

    Seizure　2022/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.seizure.2022.04.007 　

    ISSN： 1059-1311

  236. Characteristics of hospitals that report adverse drug reactions: Results of a nationwide survey in Japan

    Masami Tsuchiya, Daisuke Kikuchi, Shiro Hatakeyama, Yuichi Tasaka, Takeshi Uchikura, Ryohkan Funakoshi, Taku Obara

    Journal of Clinical Pharmacy and Therapeutics　2022/03/31

    Publisher: Wiley

    DOI： 10.1111/jcpt.13661 　

    ISSN： 0269-4727

    eISSN： 1365-2710

  237. Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study. International-journal

    Chikana Kawaguchi, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Shinichi Kuriyama, Taku Obara

    BMC pregnancy and childbirth　22　(1)　242-242　2022/03/24

    DOI： 10.1186/s12884-022-04556-8 　

    More details Close

    BACKGROUND: Maternal mental health problems in each of the prenatal period and postnatal period have been demonstrated as possible risk factors for atopic dermatitis (AD) in children. However, the cumulative impacts of maternal psychological distress in the prenatal and postnatal periods on AD in children remain unclear. This study examined the association between cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and the development of AD in children. METHODS: Data were derived from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. In total, 8377 mother-child pairs in which the child had no AD at the age of 1 year were analyzed. Maternal psychological distress in early pregnancy and 1 year after delivery was defined as a K6 score ≥ 5, and the participants were categorized into four groups: no psychological distress in both the prenatal and postnatal periods; only the prenatal period; only the postnatal period; and both periods. The development of AD was defined as the presence of AD in a 2-year-old child without AD reported at the age of 1 year using the International Study of Asthma and Allergies in Childhood questionnaire. Generalized linear model analyses were conducted to examine the association between maternal psychological distress and the development of AD in children adjusted for age at delivery, educational attainment, smoking status in pregnancy, maternal history of AD, paternal history of AD, parity, maternal body mass index, and child sex. RESULTS: Between the ages of 1 and 2 years, 14.0% of children developed AD. Maternal psychological distress in both prenatal and postnatal periods was associated with an increased risk of AD in children compared to no psychological distress in both periods (relative risk (RR), 95% confidence interval (CI): 1.34, 1.20-1.47). Maternal psychological distress in only the postnatal period was associated with an increased risk of AD in children (RR, 95% CI: 1.23, 1.07-1.39), but not in only the prenatal period (RR, 95% CI: 1.14, 0.98-1.30). CONCLUSIONS: Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods was associated with the development of AD in children.

  238. Trends in drug prescriptions for type 2 diabetes, hypertension, and dyslipidemia among adults with non-alcoholic fatty liver disease. International-journal

    Toshiya Machida, Taku Obara, Makoto Miyazaki, Jun Inoue, Nariyasu Mano

    Annals of hepatology　27　(4)　100699-100699　2022/03/09

    DOI： 10.1016/j.aohep.2022.100699 　

    More details Close

    INTRODUCTION AND OBJECTIVES: Clinical guidelines recommend specific drugs for type 2 diabetes (T2D), hypertension, and dyslipidemia in patients with non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH). We aimed to investigate the differences in prescription trends of antidiabetic, antihypertensive, and lipid-lowering drugs among adult patients according to the presence of comorbid NAFLD and/or NASH. METHODS: We conducted a cross-sectional analysis using a large claims database from January 2013 to December 2020. RESULTS: Among 7,716,908 people, 47,157 patients with T2D, 180,050 with hypertension, and 191,348 with dyslipidemia were identified. A total of 8,897, 16,451, and 24,762 patients with NAFLD, as well as 435, 523, and 1033 patients with NASH, had T2D, hypertension, and dyslipidemia, respectively. Among antidiabetic drugs, sodium-glucose cotransporter-2 inhibitors (SGLT2is) and thiazolidine were more frequently prescribed to patients with NAFLD than to those without NAFLD (non-NAFLD) (thiazolidine: 1.4% and 2.8% and SGLT2is: 17.8% and 25.9% for non-NAFLD and NAFLD, respectively [2019-2020]). Among antihypertensive drugs, angiotensin II receptor antagonists exhibited a slightly higher prescription ratio in patients with NAFLD (33.6% vs. 39.0%). Regarding lipid-lowering drugs, fibrates were more frequently prescribed to patients with NAFLD (10.3% vs. 18.4%). CONCLUSIONS: Specific drugs tended to be prescribed to patients with NAFLD. However, the differences in prescription ratios were not considerable. Further investigation is required to confirm the effects of drugs on the prognosis of patients with NAFLD or NASH.

  239. 妊婦における社会的孤立と不眠との関連 三世代コホート調査

    村上 慶子, 石黒 真美, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 小原 拓, 栗山 進一

    日本衛生学雑誌　77　(Suppl.)　S211-S211　2022/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  240. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan

    Nobuo Fuse, Miyuki Sakurai, Ikuko N. Motoike, Kaname Kojima, Takako Takai-Igarashi, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Akiko Miyazawa, Kei Homma, Keisuke Ido, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Akira Uruno, Eiichi N. Kodama, Kichiya Suzuki, Yohei Hamanaka, Hiroaki Tomita, Junichi Sugawara, Yoichi Suzuki, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto

    Ophthalmology Science　2　(1)　100113-100113　2022/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.xops.2022.100113 　

    ISSN： 2666-9145

  241. Assessment of Information Sharing on Adverse Drug Reactions by Community Pharmacies with Other Medical Institutions

    Daisuke Kikuchi, Taku Obara, Aoi Noda, Gen Oyanagi, Mami Ishikuro, Kouji Okada, Nariyasu Mano

    Pharmacy　10　(1)　25-25　2022/02/05

    Publisher: MDPI AG

    DOI： 10.3390/pharmacy10010025 　

    eISSN： 2226-4787

    More details Close

    Widespread coordination and sharing of information regarding adverse drug reactions (ADRs) are important for drug safety assessment. However, the actual status of coordination and sharing of information on ADRs in community pharmacies remains unclear. Therefore, a survey was conducted at community pharmacies to analyze the status. In this cross-sectional study conducted from 31 March 2021 to 9 April 2021, a request letter with the uniform resource locator of the questionnaire form was sent to 302 community pharmacies affiliated with Tsuruha Holdings Inc., and the responses were obtained online. The response rate for the questionnaires was 80.8% (n = 244). In total, 20.9% of the community pharmacies provided information on patients’ ADRs to hospitals or clinics prescribing drugs. None of the community pharmacies provided patient ADR information to other community pharmacies. Of the community pharmacies, 98.8% felt that insufficient information was available to monitor ADRs from hospitals or clinics prescribing drugs. For example, the name of the disease (67.6%), considered to be the most common information, was insufficiently provided. Overall, the existing system for providing information on ADRs between community pharmacies and other medical institutions is insufficient and needs to be developed further.

  242. Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: The Japan Environment and Children's Study. International-journal

    Taeko Suzuki, Toshie Nishigori, Taku Obara, Toshio Masumoto, Miyuki Mori, Tsuyoshi Murata, Hyo Kyozuka, Yuka Ogata, Akiko Sato, Mari Sanpei, Toshifumi Takahashi, Kosei Shinoki, Mitsuaki Hosoya, Keiya Fujimori, Seiji Yasumura, Koichi Hashimoto, Aya Goto, Hidekazu Nishigori

    The British journal of nutrition　1-24　2022/02/04

    DOI： 10.1017/S000711452200037X 　

    More details Close

    We evaluated the association between maternal prenatal folic acid supplementation/dietary folate intake and motor and cognitive development in 2-year-old offspring using data from the Japan Environment and Children's Study database. Neurodevelopment of 2-year-old offspring were evaluated using the Kyoto Scale of Psychological Development 2001. In total, data of 3,839 offspring were analysed. For folic acid supplementation, a multiple regression analysis showed that offspring of mothers who started using folic acid supplements before conception had a significantly lower developmental quotient (DQ) in the postural-motor DQ area than offspring of mothers who did not use them at any time throughout their pregnancy (partial regression coefficient [B]: -2.596, 95% confidence interval [CI]: - 4.738 - -0.455). Regarding daily dietary folate intake from preconception to early pregnancy, a multiple regression analysis showed that the group with ≥200 µg had a significantly higher DQ in the language-social area than the group with <200 µg. The DQ was higher in the ≥400 µg group (B: 2.532, 95%CI: 0.201-4.863) than the 200 to <400 µg group (B: 1.437, 95% CI: 0.215-2.660). In conclusion, our study showed that maternal adequate dietary folate intake from preconception to early pregnancy has a beneficial association with verbal cognition development in 2-year-old offspring. On the other hand, mothers who started using folic acid supplements before conception had an inverse association with motor development in 2-year-old offspring. There were no details on the amount of folic acid in the supplements used and frequency of use. Therefore, further studies are required.

  243. 研究者の最新動向 副作用報告に関する海外実態調査

    酒井 隆全, 門田 佳子, 小原 拓

    Precision Medicine　5　(2)　166-171　2022/02

    Publisher: (株)北隆館

    ISSN： 2434-3625

  244. Families' Health after the Great East Japan Earthquake: Findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Mami Ishikuro, Aoii Noda, Keiko Murakami, Tomomi Onuma, Fumiko Matsuzaki, Fumihiko Ueno, Masahiro Kikuya, Hirohito Metoki, Hiroaki Tomita, Taku Obara, Nobuo Yaegashi, Shinichi Kuriyama

    The Tohoku journal of experimental medicine　256　(2)　93-101　2022/02

    DOI： 10.1620/tjem.256.93 　

    More details Close

    Infectious diseases, chronic diseases, and mental disorders in both adults and children are reported after disasters occur. The correlation between chronic diseases and mental disorders has also been reported. Moreover, disasters may affect perinatal outcomes. Thus, both adult and child health should be carefully monitored in disaster aftermath. A prospective cohort study of pregnant women and their families, the Tohoku Medical Megabank Project (TMM) Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), has been conducted since 2013. A total of 73,529 family members participated in the TMM BirThree Cohort Study. Among siblings, the proportion of "small for gestational age" was the same in the pre- and post-disaster periods. Among parents and grandparents who answered the baseline questionnaire, 5.6% in the inland area and 19.8% in the coastal area had their houses totally/mostly destroyed by the Great East Japan Earthquake. Although a depression trend due to house damage was not observed in mothers, the proportion of psychological distress was high according to house damage (P for trend = 0.04). Among parents, there was an increase in overweight persons (P for trend = 0.004 in mothers and < 0.0001 in fathers) and in the number of smokers based on the severity of house damage (P for trend = 0.002 in mothers and < 0.0001 in fathers), whereas no such trend was observed in grandparents. Continuous monitoring and support for those who need are essential. Moreover, utilizing existing cohort studies to investigate health status when we face a new disaster is desirable.

  245. コロナ禍とうつ傾向との関連及びその地域差の探索 東北メディカル・メガバンク計画三世代コホート調査

    大瀬戸 恒志, 石黒 真美, 村上 慶子, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 上野 史彦, 小原 拓, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　130-130　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  246. 妊婦の朝食欠食と妊娠高血圧症候群との関連 東北メディカル・メガバンク計画三世代コホート調査

    相澤 美里, 村上 慶子, 高橋 一平, 大沼 ともみ, 野田 あおい, 上野 史彦, 松崎 芙実子, 石黒 真美, 小原 拓, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　133-133　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  247. 不妊治療により出生した児における精神運動発達の推移 東北メディカル・メガバンク計画三世代コホート調査

    野田 あおい, 石黒 真美, 村上 慶子, 上野 史彦, 大沼 ともみ, 松崎 芙実子, 小原 拓, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　141-141　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  248. 乳幼児期から思春期までの経時的な体格に関する検討解析 東北メディカル・メガバンク計画三世代コホート調査

    上野 史彦, 長岡 勇大, 黒川 修行, 高橋 一平, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 村上 慶子, 石黒 真美, 小原 拓, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　143-143　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  249. 東北メディカル・メガバンク計画三世代コホート調査の進捗

    小原 拓, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 中谷 直樹, 寳澤 篤, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　155-155　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  250. 乳児期の体重変化と幼児期過体重・肥満との関連 東北メディカル・メガバンク計画三世代コホート調査

    小林 雅幸, 石黒 真美, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 上野 史彦, 村上 慶子, 小原 拓, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　100-100　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  251. Association between Recurrence or Exacerbation at Time of Disaster and Allergic Symptoms Several Years Later in Schoolchildren with Asthma or Atopic Dermatitis: The ToMMo Child Health Study

    Masako Miyashita, Taku Obara, Mami Ishikuro, Masahiro Kikuya, Shinichi Kuriyama

    The Tohoku Journal of Experimental Medicine　257　(1)　23-32　2022

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2022.j018 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  252. Epidemiological survey to establish thresholds for influenza among children in satellite cities of Tokyo, Japan, 2014-2018. International-journal

    Ayako Matsuda, Kei Asayama, Taku Obara, Naoto Yagi, Takayoshi Ohkubo

    Western Pacific surveillance and response journal : WPSAR　13　(3)　1-9　2022

    DOI： 10.5365/wpsar.2022.13.3.911 　

    More details Close

    OBJECTIVE: We described the characteristics of children reported as having influenza across five consecutive influenza seasons and investigated the usefulness of setting influenza thresholds in two satellite cities of Tokyo, Japan. METHODS: An annual survey was conducted among parents of children at preschools (kindergartens and nursery schools), elementary schools and junior high schools in Toda and Warabi cities, Saitama prefecture, at the end of the 2014-2018 influenza seasons. Using the World Health Organization method, we established seasonal, high and alert thresholds. RESULTS: There were 64 586 children included in the analysis. Over the five seasons, between 19.1% and 22% of children annually were reported as having tested positive for influenza. Influenza type A was reported as the dominant type, although type B was also reported in more than 40% of cases in the 2015 and 2017 seasons. The median period of the seasonal peak was 3 weeks in mid-January, regardless of school level. Of the five surveyed seasons, the high threshold was reached in 2014 and 2018, with no season exceeding the alert threshold. DISCUSSION: This study provides insights into the circulation of influenza in children in the study areas of Toda and Warabi, Japan, from 2014 to 2018. Although we were able to utilize these annual surveys to calculate influenza thresholds from five consecutive seasons, the prospective usefulness of these thresholds is limited as the survey is conducted at the end of the influenza season.

  253. 妊娠初期の消化管運動改善薬処方と児の大奇形との関連 大規模レセプトデータベースを用いた評価

    石川 智史, 小原 拓, 赤沢 学, 野田 あおい, 大柳 元, 森下 啓, 都田 桂子, 西郡 秀和, 川目 裕, 八重樫 伸生, 栗山 進一, 眞野 成康

    Journal of Epidemiology　32　(Suppl.1)　141-141　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  254. 日本人妊婦の食事パターンとSGAとの関連 三世代コホート調査

    山下 貴宏, 小原 拓, 米沢 祐大, 高橋 一平, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 岩間 憲之, 菅原 準一, 鈴木 重徳, 菅沼 大行, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　132-132　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  255. 母親の妊娠中と産後の心理的ストレス反応と児の問題行動との関連 三世代コホート調査

    高橋 一平, 村上 慶子, 五十嵐 彩華, 小林 美佳, 菊地 紗耶, 大柳 元, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 上野 史彦, 石黒 真美, 小原 拓, 菅原 準一, 富田 博秋, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　143-143　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  256. 首都圏地方都市在住小児におけるインフルエンザワクチン接種とインフルエンザ発症との関連 2014/2015-2018/2019シーズン

    松田 彩子, 浅山 敬, 小原 拓, 八木 直人, 大久保 孝義

    Journal of Epidemiology　32　(Suppl.1)　113-113　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  257. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology　32　(Suppl.1)　162-162　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  258. Association between smoking and hypertension in pregnancy among Japanese women: a meta-analysis of birth cohort studies in the Japan Birth Cohort Consortium (JBiCC) and JECS

    Naho Morisaki, Taku Obara, Aurelie Piedvache, Sumitaka Kobayashi, Chihiro Miyashita, Tomoko Nishimura, Mami Ishikuro, Fumihiro Sata, Reiko Horikawa, Chisato Mori, Hirohito Metoki, Kenji J Tsuchiya, Shinichi Kuriyama, Reiko Kishi

    Journal of Epidemiology　2022

    Publisher: Japan Epidemiological Association

    DOI： 10.2188/jea.je20220076 　

    ISSN： 0917-5040

    eISSN： 1349-9092

  259. 妊娠高血圧症候群と産後約3年の血圧値との関連 東北メディカル・メガバンク計画三世代コホート調査

    石黒 真美, 長谷川 茉柚, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 菊谷 昌浩, 目時 弘仁, 小原 拓, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　100-100　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  260. 日本人妊婦の食事パターンとSGAとの関連 三世代コホート調査

    山下 貴宏, 小原 拓, 米沢 祐大, 高橋 一平, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 岩間 憲之, 菅原 準一, 鈴木 重徳, 菅沼 大行, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　132-132　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  261. 母親の妊娠中と産後の心理的ストレス反応と児の問題行動との関連 三世代コホート調査

    高橋 一平, 村上 慶子, 五十嵐 彩華, 小林 美佳, 菊地 紗耶, 大柳 元, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 上野 史彦, 石黒 真美, 小原 拓, 菅原 準一, 富田 博秋, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　143-143　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  262. 妊娠初期の消化管運動改善薬処方と児の大奇形との関連 大規模レセプトデータベースを用いた評価

    石川 智史, 小原 拓, 赤沢 学, 野田 あおい, 大柳 元, 森下 啓, 都田 桂子, 西郡 秀和, 川目 裕, 八重樫 伸生, 栗山 進一, 眞野 成康

    Journal of Epidemiology　32　(Suppl.1)　141-141　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  263. 健康保険組合・国民健康保険の健診データに基づく2018〜2020年度の血圧変化とその要因

    佐藤 倫広, 村上 任尚, 小原 拓, 目時 弘仁

    Journal of Epidemiology　32　(Suppl.1)　128-128　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  264. Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study

    Mana Kogure, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Kotaro Nochioka, Akira Narita, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Taku Obara, Michihiro Satoh, Hirohito Metoki, Ken Miyagawa, Hiroshi Koshimizu, Sho Nagayoshi, Akira Uruno, Masahiro Kikuya, Kichiya Suzuki, Naoki Nakaya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension Research　2022

    DOI： 10.1038/s41440-021-00843-7 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  265. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. International-journal

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    Human genome variation　8　(1)　44-44　2021/12/10

    DOI： 10.1038/s41439-021-00175-5 　

    More details Close

    To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

  266. Prenatal folic acid supplementation and autism spectrum disorder in 3-year-old offspring: the Japan environment and children's study. International-journal

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Mami Ishikuro, Nozomi Tatsuta, Kasumi Sakurai, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　35　(25)　1-10　2021/12/02

    DOI： 10.1080/14767058.2021.2007238 　

    More details Close

    OBJECTIVE: We evaluated the relationship between prenatal folic acid supplementation and autism spectrum disorder (ASD) in 3-year-old offspring. METHODS: We used data from the Japan Environment and Children's Study, a nationwide prospective birth cohort study. We analyzed the data to determine the association between folic acid supplement use and the incidence of ASD in offspring, and classified participants into three groups based on the time of initiation of folic acid supplementation, as follows: (1) preconception users of folic acid supplements and (2) post-conception users, and (3) non-users. The dietary folate intake of study participants was also classified into three groups (<200 µg, 200 µg to <400 µg, ≥400 µg). RESULTS: Overall, 361 offspring of 96,931 participants with single pregnancies were diagnosed with ASD (0.37%). A total of 7,046 participants (7.3%) used folic acid supplements before conception, 29,984 (30.9%) took them after detection of pregnancy, and 59,901 (61.8%) never received them. Multivariate logistic regression analyses demonstrated no association between prenatal folic acid supplementation and ASD in offspring (preconception use: adjusted odds ratio [AOR], 1.189; 95% confidence interval [CI], 0.819-1.727 and post-conception use: AOR, 1.072; 95% CI, 0.840-1.368); additionally, no association was observed with the use of folic acid supplements and/or multivitamin supplements (preconception use: AOR, 1.273; 95% CI, 0.921-1.760 and post-conception use: AOR, 1.132; 95% CI, 0.885-1.449). Moreover, no significant association was observed in participants with combined prenatal supplement use and dietary folate intake. CONCLUSIONS: Maternal use of folic acid supplements from the pre- or post-conception period was not significantly associated with ASD in 3-year-old offspring in Japan. Evaluation of the dietary folate intake from preconception also showed no significant association.

  267. Living environments long-term after the Great East Japan Earthquake and nutritional intake among recent mothers. International-journal

    Takahiro Yamashita, Keiko Murakami, Taku Obara, Yudai Yonezawa, Mami Ishikuro, Aoi Noda, Fumihiko Ueno, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

    Asia Pacific journal of clinical nutrition　30　(4)　651-661　2021/12

    DOI： 10.6133/apjcn.202112_30(4).0012 　

    More details Close

    BACKGROUND AND OBJECTIVES: Although large-scale natural disasters and the resultant changes in living environments worsen dietary habits among adults immediately after the disasters, whether this association remains for a long period is unclear. This is particularly important for recent mothers because lactating women require additional nutrition for milk production. Thus, we investigated the association of living environments with dietary habits and nutritional intake of recent mothers between four and seven years after the Great East Japan Earthquake (11th March, 2011). METHODS AND STUDY DESIGN: We analyzed 8,551 mothers who participated to the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Living environments were characterized into four categories: "same home before the earthquake", "rental housing", "reconstructed home", and "acquaintance's home". Dietary habits and nutritional intake were evaluated using a food frequency questionnaire answered 12 months after their deliveries (the questionnaire was answered between March 2015 and July 2018). RESULTS: Multiple linear regression analyses demonstrated that mothers in 'rental housing' or 'reconstructed home' had a significantly lower intake of almost all nutrients or certain nutrients, respectively, compared with those residing in 'same home before the earthquake'. However, fewer significant differences were detected between the nutritional intake of the mothers lodging in an 'acquaintance's home' and that of those living in 'same home before the earthquake'. CONCLUSIONS: Our findings indicate that living environments long-term after largescale disasters are associated with dietary habits and nutritional intake among recent mothers.

  268. Enhancement and evaluation of a prescription audit system for direct oral anticoagulants using a check sheet

    Naoto Ishikawa, Hanae Oshikiri, Shinya Takasaki, Masafumi Kikuchi, Taku Obara, Kazutoshi Akasaka, Masaki Matsuura, Hiroaki Yamaguchi, Nariyasu Mano

    Journal of Pharmaceutical Health Care and Sciences　7　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40780-021-00205-y 　

    eISSN： 2055-0294

    More details Close

    <title>Abstract</title><sec> <title>Background</title> Renal function and use of concomitant medications should be carefully monitored in patients subjected to treatment with direct oral anticoagulants (DOACs); the dose should be individually designed for each patient. Owing to the complex therapeutic indications and dose reduction criteria, pharmacists exercise caution when determining the optimal dose for each patient. A DOAC check sheet has been developed that is automatically printed in the dispensing room at the same time as the prescription and can be used by pharmacists to dispense DOACs promptly and correctly. The purpose of this study was to evaluate the system for dispensing DOACs using a check sheet. </sec><sec> <title>Methods</title> The study was conducted at Tohoku University Hospital in Japan; prescriptions containing DOACs dispensed by the hospital pharmacists were evaluated. The DOAC check sheet described indications, dosage regimens, dose reduction criteria, and contraindications for each drug and included the patient’s information. The check sheet was set to print automatically in the dispensing room at the same time as the prescription when an inpatient was prescribed DOACs. This check sheet was evaluated using a prescription survey and a questionnaire for pharmacists. </sec><sec> <title>Results</title> The usefulness of this check sheet for the correct use of DOACs was evaluated. There were four inquiries out of 642 (0.6%) prescriptions from pharmacists to physicians regarding DOAC prescriptions, such as the dose introduced before DOAC check sheet utilization, and there were 21 out of 905 (2.3%) prescriptions when the DOAC check sheet was used it, showing a significant increase (<italic>p</italic> = 0.0089). After the introduction of this sheet, overdoses of DOACs were identified at the time of dispensing. Of the 52 pharmacists who responded to the questionnaire, 51 (98%) stated that the check sheet was useful. </sec><sec> <title>Conclusion</title> The use of the DOAC check sheet is likely to render safety to DOAC drug therapy for individual patients. </sec>

  269. Impact of local vaccine subsidization programs on the prevention of mumps in Japan. International-journal

    Makoto Miyazaki, Taku Obara, Nariyasu Mano

    Human vaccines & immunotherapeutics　17　(11)　4216-4224　2021/11/02

    DOI： 10.1080/21645515.2021.1974797 　

    More details Close

    In Japan, although a mumps vaccination is outside the national universal vaccination program, some local governments have implemented their own program. However, little is known regarding the implementation status and the impact of these programs. In this study, we investigated the impact on the prevention of mumps, after identification of the status of the local government subsidization programs. We identified the implementation status of the subsidization programs using the websites of local governments. We retrieved the number of reported mumps cases from designated sentinel sites through the Surveillance of Infectious Diseases System implemented according to the Infectious Disease Control Law. Using this data, the impact of the subsidization program on prevention of mumps was assessed by comparing the number of mumps cases per site during the 2015-2016 outbreak among the areas categorized by the subsidization status, using a Poisson regression model. As of 2019, 26.2% (456/1,739) of the local governments were considered as having subsidization programs. We retrieved 52,719 mumps cases from 2010 to 2019. The number of mumps cases per sentinel site tended to be low in areas implementing a subsidization program, compared with the no-implementation areas throughout the data collection period. The adjusted model confirmed that the subsidization program implemented between 2010 and 2015 impacted on the number of mumps cases during the 2015-2016 outbreak, with a decrease in the numbers. Further studies with detailed data including vaccination coverage should be conducted.

  270. リアルワールドにおけるアンジオテンシンII受容体拮抗薬とジヒドロピリジン系Ca拮抗薬の腎機能への影響

    佐藤 倫広, 廣瀬 卓男, 佐藤 弘典, 中山 晋吾, 小原 拓, 村上 任尚, 室谷 智子, 浅山 敬, 菊谷 昌浩, 森 建文, 今井 潤, 大久保 孝義, 目時 弘仁

    薬剤疫学　26　(Suppl.)　S133-S134　2021/11

    Publisher: (一社)日本薬剤疫学会

    ISSN： 1342-0445

    eISSN： 1882-790X

  271. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 中谷 久美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　80回　219-219　2021/11

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  272. リアルワールドにおけるアンジオテンシンII受容体拮抗薬とジヒドロピリジン系Ca拮抗薬の腎機能への影響

    佐藤 倫広, 廣瀬 卓男, 佐藤 弘典, 中山 晋吾, 小原 拓, 村上 任尚, 室谷 智子, 浅山 敬, 菊谷 昌浩, 森 建文, 今井 潤, 大久保 孝義, 目時 弘仁

    薬剤疫学　26　(Suppl.)　S133-S134　2021/11

    Publisher: (一社)日本薬剤疫学会

    ISSN： 1342-0445

    eISSN： 1882-790X

  273. Maternal personality and alcohol use during pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

    Addictive behaviors　122　107020-107020　2021/11

    DOI： 10.1016/j.addbeh.2021.107020 　

    More details Close

    BACKGROUND: Studies on associations between maternal personality and alcohol use have examined only one time point during pregnancy in Western countries. We aimed to examine the association between maternal personality and alcohol use in early and middle pregnancy in Japan. METHODS: We analyzed data from 17,144 pregnant women in Japan who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Personality was assessed using the short-form Eysenck Personality Questionnaire-Revised. Women were dichotomized as current drinkers or non-drinkers in both early and middle pregnancy. Odds ratios (ORs) and 95% confidence intervals (CIs) for alcohol use in early and middle pregnancy and continued alcohol use between early and middle pregnancy were calculated for 1 standard deviation increase in each personality scale, adjusted for age, as well as education, work status, fertility treatment, and parity. RESULTS: Higher extraversion scores were associated with alcohol use in early (OR, 1.16; 95% CI, 1.12-1.20) and middle pregnancy (OR, 1.17; 95% CI, 1.10-1.25). Higher psychoticism scores were associated with continued alcohol use into middle pregnancy (OR, 1.07; 95% CI, 1.01-1.14) and alcohol use in middle pregnancy (OR, 1.07; 95% CI, 1.02-1.13). Neuroticism was not associated with alcohol use in early or middle pregnancy. Lower lie was associated with alcohol use in early (OR, 0.95; 95% CI, 0.91-0.98), but not in middle pregnancy. CONCLUSIONS: Different personality scales are associated with alcohol use at different points during pregnancy.

  274. Risk of major congenital malformations associated with first-trimester exposure to propulsives: A health administrative database study in Japan. International-journal

    Tomofumi Ishikawa, Taku Obara, Manabu Akazawa, Aoi Noda, Gen Oyanagi, Kei Morishita, Keiko Miyakoda, Hidekazu Nishigori, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    Pharmacoepidemiology and drug safety　31　(2)　196-205　2021/10/10

    DOI： 10.1002/pds.5370 　

    More details Close

    PURPOSE: To evaluate the risk of major congenital malformations (MCMs) associated with first-trimester exposure to propulsives with a special focus on domperidone using a large administrative database in Japan. METHODS: A large claims database was used from January 2005 to August 2016. The dates of pregnancy onset and delivery were estimated using the developed algorithms. Major congenital malformations were defined according to the International Classification of Diseases, 10th revision codes. We compared the infants' risk of overall MCMs between women with or without first-trimester prescriptions of propulsives and estimated the odds ratios (ORs) with unadjusted and adjusted analyses. We also compared the risk of overall MCMs between women with domperidone prescriptions and those with other propulsive prescriptions during the first trimester. RESULTS: Among 38 270 women, propulsives were prescribed to 3197 women (8.4%) in the first trimester, including domperidone to 371 women (1.0%). Propulsive prescriptions in the first trimester were not significantly associated with an increased risk of overall MCMs (adjusted OR [aOR] 1.030, 95% confidence interval [CI] 0.843-1.257). Compared to the prescription of other propulsives in the first trimester, the prescription of domperidone in the first trimester was not associated with an increased risk of overall MCMs (aOR 0.724, 95% CI 0.363-1.447). CONCLUSIONS: The first-trimester prescription of propulsives, including domperidone, was not associated with an increased risk of overall MCMs. This article is protected by copyright. All rights reserved.

  275. Augmentation method for convolutional neural network that improves prediction performance in the task of classifying primary lung cancer and lung metastasis using CT images

    Takuma Usuzaki, Kengo Takahashi, Kazuma Umemiya, Mami Ishikuro, Taku Obara, Masahiro Kamimoto, Kazuhiro Majima

    Lung Cancer　160　175-178　2021/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.lungcan.2021.06.021 　

    ISSN： 0169-5002

  276. Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies. International-journal

    Naoki Nakaya, Tian Xie, Bart Scheerder, Naho Tsuchiya, Akira Narita, Tomohiro Nakamura, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Harold Snieder, Shinichi Kuriyama

    Atherosclerosis　334　85-92　2021/10

    DOI： 10.1016/j.atherosclerosis.2021.08.037 　

    More details Close

    BACKGROUND AND AIMS: Few studies have examined and compared spousal concordance in different populations. This study aimed to quantify and compare spousal similarities in cardiometabolic risk factors and diseases between Dutch and Japanese populations. METHODS: This cross-sectional study included 28,265 Dutch Lifelines Cohort Study spouse pairs (2006-2013) and 5,391 Japanese Tohoku Medical Megabank Organization (ToMMo) Cohort Study pairs (2013-2016). Spousal similarities in cardiometabolic risk factors were evaluated using Pearson's correlation or logistic regression analyses adjusted for spousal age. RESULTS: The husbands' and wives' average ages in the Lifelines and ToMMo cohorts were 50.0 and 47.7 years and 63.2 and 60.4 years, respectively. Significant spousal similarities occurred with all cardiometabolic risk factors and diseases of interest in both cohorts. The age-adjusted correlation coefficients ranged from 0.032 to 0.263, with the strongest correlations observed in anthropometric traits. Spousal odds ratios [95% confidence interval] for the Lifelines vs. ToMMo cohort ranged from 1.45 (1.36-1.55) vs. 1.20 (1.05-1.38) for hypertension to 6.86 (6.30-7.48) vs. 4.60 (3.52-6.02) for current smoking. An increasing trend in spousal concordance with age was observed for sufficient physical activity in both cohorts. For current smoking, those aged 20-39 years showed the strongest concordance between pairs in both cohorts. The Dutch pairs showed stronger similarities in anthropometric traits and lifestyle habits (smoking and drinking) than their Japanese counterparts. CONCLUSIONS: Spouses showed similarities in several cardiometabolic risk factors among Dutch and Japanese populations, with regional and cultural influences on spousal similarities.

  277. Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

    Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

    2021/09/15

    Publisher: Research Square Platform LLC

    DOI： 10.21203/rs.3.rs-887730/v1 　

    More details Close

    <title>Abstract</title> ObjectiveThe aim of our study was to develop prediction model for preeclampsia (PE) using routinely examined items in early pregnancy especially dipstick test for proteinuria.MethodThe Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women and we included 9,086 of them in analysis. Maternal basic characteristics were obtained by self-report, and blood pressure and dipstick test of proteinuria were obtained by medical record at regular antenatal care. The outcome was defined as PE including superimposed preeclampsia. We developed prediction model without dipstick test of proteinuria (model 1) and model with it (model 2), and we compared them by the mean of area under the receiver operating characteristic curve (mAUROC) using five-fold cross validation.ResultsmAUROC of model 1 was 0.769 (95% CI; 0.741 to 0.797) and that of model 2 was 0.785 (95% CI; 0.758 to 0.812). The difference of two mAUROCs was 0.016 (95% CI; 0.004 to 0.028). In model 2, detection rates at false-positive rate of 5%, 10% and 20% were 40%, 49% and 64%, respectively.ConclusionsWe could develop prediction model for PE using routine antenatal care items and it was improved by including dipstick test for proteinuria.

  278. Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis. International-journal

    Takafumi Yamauchi, Daisuke Ochi, Naomi Matsukawa, Daisuke Saigusa, Mami Ishikuro, Taku Obara, Yoshiki Tsunemoto, Satsuki Kumatani, Riu Yamashita, Osamu Tanabe, Naoko Minegishi, Seizo Koshiba, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi, Masayuki Yamamoto, Masao Nagasaki, Satoshi Hiyama, Junichi Sugawara

    Scientific reports　11　(1)　17777-17777　2021/09/07

    DOI： 10.1038/s41598-021-97342-z 　

    More details Close

    The elucidation of dynamic metabolomic changes during gestation is particularly important for the development of methods to evaluate pregnancy status or achieve earlier detection of pregnancy-related complications. Some studies have constructed models to evaluate pregnancy status and predict gestational age using omics data from blood biospecimens; however, less invasive methods are desired. Here we propose a model to predict gestational age, using urinary metabolite information. In our prospective cohort study, we collected 2741 urine samples from 187 healthy pregnant women, 23 patients with hypertensive disorders of pregnancy, and 14 patients with spontaneous preterm birth. Using gas chromatography-tandem mass spectrometry, we identified 184 urinary metabolites that showed dynamic systematic changes in healthy pregnant women according to gestational age. A model to predict gestational age during normal pregnancy progression was constructed; the correlation coefficient between actual and predicted weeks of gestation was 0.86. The predicted gestational ages of cases with hypertensive disorders of pregnancy exhibited significant progression, compared with actual gestational ages. This is the first study to predict gestational age in normal and complicated pregnancies by using urinary metabolite information. Minimally invasive urinary metabolomics might facilitate changes in the prediction of gestational age in various clinical settings.

  279. One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Saya Kikuchi, Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Natsuko Kobayashi, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Hiroaki Tomita

    Journal of affective disorders　295　632-638　2021/09/04

    DOI： 10.1016/j.jad.2021.08.118 　

    More details Close

    BACKGROUND: Trajectories of postpartum depressive symptoms up to 1 year after childbirth and the related risk factors remain unclear. Accordingly, this study aimed to examine the 1-year trajectories of postpartum depressive symptoms and their associated risk factors. METHODS: A total of 22,493 pregnant women were recruited between July 2013 and September 2016 in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. Among them, 11,668 women with no missing data were included in the analyses. Depressive symptoms were assessed at 1 month and 1 year postpartum using the Edinburgh Postnatal Depression Scale. Multinominal logistic regression analysis was conducted after adjusting for covariates. RESULTS: The prevalence of depression was 13.9% at 1 month and 12.9% at 1 year postpartum. We identified four depression trajectories, i.e., "persistent (depressed throughout the 1 year postpartum)" (6.0%), "recovered (depressed at 1 month postpartum and recovered within a year)" (7.9%), "late-onset (became depressed after 1 month postpartum)" (6.8%), and "resilient (not depressed throughout 1 year postpartum)" (79.2%). Psychological distress during pregnancy was significantly associated with all trajectories (persistent: odds ratio [OR]=10.24, 95% confidence interval (CI)=8.40-12.48; recovered: OR=3.78, 95%CI=3.28-4.36; and late-onset: OR=3.96, 95%CI=3.40-4.62). LIMITATIONS: Postpartum depression was evaluated only by a self-administered questionnaire and the dropout rate was not neglectable. CONCLUSIONS: This study highlighted the high prevalence of depressive symptoms at 1 year postpartum and found that half of the depressive symptoms at 1 year were late-onset. The findings suggest the necessity of long-term follow-up (up to 1 year) for perinatal mental health.

  280. 東北メディカル・メガバンク計画 三世代コホート調査の進捗報告

    石黒 真美, 小原 拓, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 菊谷 昌浩, 目時 弘仁, 菅原 準一, 栗山 進一

    DOHaD研究　9　(1)　28-28　2021/09

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  281. 出生コホート連携に基づく胎児期から乳幼児期の環境と母児の予後との関連に関する研究

    小原 拓, 岸 玲子, 佐田 文宏, 清水 厚志, 菅原 準一, 土屋 賢治, 堀川 玲子, 目時 弘仁, 森崎 菜穂, 森 千里, 栗山 進一

    DOHaD研究　9　(1)　77-77　2021/09

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  282. 662Factors associated with smoking continuation and indoor smoking among pregnant women’s partners

    Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

    International Journal of Epidemiology　50　(Supplement_1)　2021/09/01

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/ije/dyab168.464 　

    ISSN： 0300-5771

    eISSN： 1464-3685

    More details Close

    <title>Abstract</title> <sec> <title>Background</title> Secondhand smoke by partners is a major source of exposure for non-smoking women. However, factors associated with smoking continuation and indoor smoking among pregnant women’s partners remain unknown. </sec> <sec> <title>Methods</title> We used data from 6348 partners of non-smoking pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan from 2013 to 2017. Partners’ age, educational attainment, equivalent household income, and pregnant women’s smoking history (never, quitting before pregnancy awareness, quitting after pregnancy awareness) were used as explanatory variables. Multivariate logistic regression analyses were conducted to examine the associations between these variables and smoking continuation/indoor smoking of partners. </sec> <sec> <title>Results</title> Among 6348 partners, 2506 partners had been smokers at pregnancy awareness. Among them, the prevalence of smoking continuation after pregnancy awareness was 92.0%. Partners whose wives had quitted smoking after pregnancy awareness were less likely to continue smoking than partners whose wives had never smoked; the odds ratio was 0.57 (95% confidence interval, 0.41–0.80). Among partners who continued smoking, the prevalence of indoor smoking was 30.7%. Partners with ≤high school education were more likely to smoke indoors than partners with ≥university education; the odds ratio was 1.60 (95% confidence interval, 1.23–2.07). </sec> <sec> <title>Conclusions</title> Women’s smoking cessation after pregnancy awareness was associated with decreased risk of partners’ smoking continuation, and lower level of partners’ education was associated with increased risk of partners’ indoor smoking. </sec> <sec> <title>Key messages</title> Interventions for both women and their partners may be effective in reducing secondhand smoke exposure during pregnancy. </sec>

  283. Limited consumption of 100% fruit juices and sugar sweetened beverages in Japanese toddler and preschool children. International-journal

    Janet M Wojcicki, Kenji J Tsuchiya, Keiko Murakami, Mami Ishikuro, Taku Obara, Naho Morisaki

    Preventive medicine reports　23　101409-101409　2021/09

    DOI： 10.1016/j.pmedr.2021.101409 　

    More details Close

    Japanese toddler and preschool children, ages 1.5-5 years, have lower rates of obesity, ≥95 th percentile body mass index, compared with North American ones. We examined parental reported beverage consumption patterns in 3 Japanese based mother-child cohorts from three different regions of Japan compared with data from cross-sectional and longitudinal studies from North America. Specifically, we used data from the Hamamatsu Birth Cohort for Mothers and Children (HBC Study) in Hamamatsu (Shizuoka Prefecture), the Seiiku Boshi Birth Cohort from Setagaya, Tokyo and the TMM BirThree Cohort Study from Miyagi. We additionally compared cross-sectional data from preschoolers from 24 prefectures in Japan as previously reported from a national study. While Japanese children had lower but comparable rates to North American children for introduction of sugar-sweetened beverages and 100% fruit juices, Japanese children consumed these beverages daily at a much lower level than North American children. Additionally, North American children may get more added sugars from soda and fruit juices as a relative percentage of total added sugar. By contrast, Japanese children consume more sweetened dairy drinks as a relative percentage of total added sugar. Sweetened dairy drinks may have the added benefits of including fats, calcium and probiotics which may be associated with lower risk for obesity compared with consumption of other types of sugar sweetened beverages.

  284. Hypertension in pregnancy as a possible factor for child autistic behavior at two years old. International-journal

    Mami Ishikuro, Keiko Murakami, Fumiya Yokozeki, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Taku Obara, Shinichi Kuriyama

    Pregnancy hypertension　25　88-90　2021/08

    DOI： 10.1016/j.preghy.2021.05.020 　

    More details Close

    We investigated the association between hypertensive disorders of pregnancy (HDP) subtypes and child autistic behavior to accumulate the evidence. We found the association between superimposed preeclampsia and autistic behavior in children aged two years old by investigating 6794 mother-child pairs in the birth cohort study. Since early intervention for autism-spectrum disorder might be effective, it suggests that early prediction is necessary for children born of mothers who developed particularly superimposed preeclampsia to support their development. Not only for introducing early prediction, but also research for establishing effective intervention is necessary.

  285. Trends in prescription of anti-seizure medicines for Japanese pediatric outpatients during 2013–2019

    Daisuke Kikuchi, Taku Obara, Shota Kashiwagura, Youtaro Arima, Hiroaki Hino, Ryosuke Miura, Sachiko Hayakawa, Yoshiteru Watanabe

    Epilepsy & Behavior Reports　100474-100474　2021/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.ebr.2021.100474 　

    ISSN： 2589-9864

  286. Prescription status of diuretics for essential hypertension in a Japanese population

    Daisuke Kikuchi, Misato Ito, Misaki Tokunaga, Kota Sasaki, Ryosuke Miura, Hiroyuki Hirakawa, Yuko Saito, Taku Obara, Yoshiteru Watanabe

    Hypertension Research　2021/07/16

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-021-00688-0 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  287. Associations of education and work status with alcohol use and cessation among pregnant women in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

    BMC public health　21　(1)　1400-1400　2021/07/15

    DOI： 10.1186/s12889-021-11461-w 　

    More details Close

    BACKGROUND: There is inconsistent evidence on the associations of education and work status with alcohol use during pregnancy. Our aim was to examine the associations of education and work status with alcohol use and alcohol cessation during pregnancy in Japan. METHODS: Data were analyzed from 11,839 pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017 in Japan. Women were dichotomized as current drinkers or non-drinkers in both early and middle pregnancy. Alcohol cessation was defined as alcohol use in early pregnancy, but not in middle pregnancy. Multivariable log-binomial regression analyses were conducted to examine associations of education and work status with alcohol use in early and middle pregnancy and alcohol cessation, adjusted for age and income. The prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated by work status and education. RESULTS: The prevalence of alcohol use in early and middle pregnancy was 20.9 and 6.4%, respectively. Higher education was associated with alcohol use in early pregnancy both among working and non-working women; the PRs of university education or higher compared with high school education or lower were 1.62 (95% CI, 1.34-1.96) and 1.29 (95% CI, 1.16-1.45), respectively. Higher education was associated with alcohol cessation during pregnancy among working women; the corresponding PR was 1.09 (95% CI, 1.01-1.17). Working was associated with alcohol use in early and middle pregnancy. Working was associated with a decreased probability of alcohol cessation among women with lower education but with an increased probability of alcohol cessation among women with higher education; the PRs of working compared with not working were 0.91 (95% CI, 0.82-1.00) and 1.10 (95% CI, 1.00-1.20), respectively. CONCLUSIONS: Women with higher education were more likely to consume alcohol in early pregnancy and to cease alcohol use between early and middle pregnancy, especially working women. Working women were more likely to consume alcohol throughout pregnancy. Working women with lower education were less likely to cease alcohol use, whereas working women with higher education were more likely to cease alcohol use between early and middle pregnancy.

  288. Associations of education and income with hazardous drinking among postpartum women in Japan: results from the TMM BirThree Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

    Environmental health and preventive medicine　26　(1)　70-70　2021/07/03

    DOI： 10.1186/s12199-021-00991-9 　

    More details Close

    BACKGROUND: Although the postpartum period is suggested to provide an ideal opportunity for interventions to prevent hazardous drinking, evidence on the associations of education and income with hazardous drinking during this period is limited, including in Japan. METHODS: We analyzed data from 11,031 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. Hazardous drinking was defined as ethanol intake of ≥20 g/day 1 year after delivery. We conducted multiple logistic regression analyses to examine whether educational attainment or equivalent household income was associated with hazardous drinking, adjusting for age, parity, drinking status during pregnancy, work status, postpartum depression, breastfeeding, and income/education. We also conducted stratified analyses by income and education groups. RESULTS: The prevalence of hazardous drinking 1 year after delivery was 3.6%. Lower education was associated with hazardous drinking; the odds ratio (95% confidence interval) of high school education or lower compared with university education or higher was 2.17 (1.59-2.98). Lower income was also associated with hazardous drinking, but this association disappeared after further adjustments for education; the odds ratios (95% confidence intervals) of the lowest compared with highest level of income were 1.42 (1.04-1.94) and 1.12 (0.81-1.54), respectively. A significant interaction was detected; lower education and lower income were associated with increased risks of hazardous drinking only in a lower income group and lower education group, respectively. CONCLUSIONS: Postpartum women with lower education and lower income had higher risks of hazardous drinking in Japan.

  289. Relation between disaster exposure, maternal characteristics, and obstetric outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Masahiro Kikuya, Junichi Sugawara, Hirohito Metoki, Shinichi Kuriyama

    Journal of epidemiology　33　(3)　127-135　2021/07/03

    DOI： 10.2188/jea.JE20210052 　

    More details Close

    BACKGROUND: The study analyzed the relation between disaster exposure prior to pregnancy, maternal characteristics, and obstetric outcomes. METHODS: The participants were 13,148 pregnant women recruited from 2013 to 2017. The women were classified into three groups by the severity of housing damage caused by the Great East Japan Earthquake of 2011: group A, house was not destroyed/did not live in the disaster area; group B, half/part of the house was destroyed; and group C, house was totally/mostly destroyed. Maternal characteristics, hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), and gestational weeks were obtained by questionnaires and medical records. Multiple logistic regression analyses were performed to investigate the relation between disaster exposure and maternal characteristics, HDP, and GDM. A structural equation model was applied to investigate the relation between disaster exposure, and HDP and gestational weeks. RESULTS: The homes of about 11% of the women were totally/mostly destroyed. For groups B and C compared with those in group A, the adjusted ORs for HDP were 1.04 and 1.26 (P for trend = 0.01), and for GDM were 0.89 and 1.14 (P for trend = 0.9), respectively. Pre-pregnancy body mass index (BMI) mediated 23.2% of the relation between disaster exposure and HDP. Disaster exposure was associated with gestational weeks. CONCLUSION: Disaster exposure at least 2.5 years before pregnancy was found to be associated with maternal characteristics and the prevalence of HDP. Pre-pregnancy BMI mediated the relation between disaster exposure and the prevalence of HDP, and gestational weeks were reduced through HDP.

  290. Identification of risk factors for mortality and delayed oral dietary intake in patients with open drainage due to deep neck infections: Nationwide study using a Japanese inpatient database Peer-reviewed

    Hiroshi Hidaka, Kunio Tarasawa, Kenji Fujimori, Taku Obara, Kiyohide Fushimi, Tomofumi Sakagami, Masao Yagi, Hiroshi Iwai

    Head & Neck　2021/07/02

    Publisher: Wiley

    DOI： 10.1002/hed.26660 　

  291. Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. International-journal

    Takumi Hirata, Mana Kogure, Naho Tsuchiya, Ken Miyagawa, Akira Narita, Kotaro Nochioka, Akira Uruno, Taku Obara, Tomohiro Nakamura, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　44　(7)　858-865　2021/07

    DOI： 10.1038/s41440-021-00628-y 　

    More details Close

    Recently, a high urinary sodium-to-potassium (Na/K) ratio and reduced sleep efficiency, in addition to conventional risk factors (obesity and excess alcohol intake), have been identified as risk factors for hypertension. We estimated the population attributable fraction (PAF) for home hypertension due to these risk factors in a general Japanese population. We conducted a cross-sectional study including 1384 participants (393 men and 991 women) to estimate the odds ratio (OR) and 95% confidence interval (CI) for the presence of any of the conventional risk factors using multivariable logistic regression analyses. The models were adjusted for sex, age, smoking status, and log-transformed average daily steps. We also estimated the OR and 95% CI for the presence of any of the overall risk factors. Furthermore, we calculated the PAF due to these risk factors. The results showed that the prevalence of home hypertension was 39.0% (540/1384). The presence of any of the conventional risk factors, as well as any of the overall risk factors, was significantly associated with an increased prevalence of hypertension (OR 2.80, 95% CI 2.15-3.65; OR 2.50, 95% CI 1.93-3.22, respectively). The PAF for hypertension due to the presence of any of the conventional risk factors and the PAF due to the presence of any of the overall risk factors were 30.2% and 39.0%, respectively. In conclusion, the impact of the overall risk factors, including the urinary Na/K ratio and sleep efficiency, on home hypertension was higher than that of conventional risk factors alone. The management of the urinary Na/K ratio and sleep efficiency as well as conventional risk factors might be important in the management of blood pressure.

  292. Validity of congenital malformation diagnoses in healthcare claims from a university hospital in Japan

    Tomofumi Ishikawa, Gen Oyanagi, Taku Obara, Aoi Noda, Kei Morishita, Shuyu Takagi, Ryusuke Inoue, Hiroshi Kawame, Nariyasu Mano

    Pharmacoepidemiology and Drug Safety　30　(7)　975-978　2021/07

    Publisher: Wiley

    DOI： 10.1002/pds.5244 　

    ISSN： 1053-8569

    eISSN： 1099-1557

  293. Grain consumption before and during pregnancy and birth weight in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

    European journal of clinical nutrition　76　(2)　261-269　2021/06/15

    DOI： 10.1038/s41430-021-00939-w 　

    More details Close

    BACKGROUND/OBJECTIVES: Studies have reported the effects of grain consumption on human health, but the association between maternal grain consumption before and during pregnancy and birth weight remains unclear. We evaluated the association between maternal grain consumption before and during pregnancy and birth weight/low birth weight (LBW). SUBJECTS/METHODS: Grain consumption was calculated using two semi-quantitative food frequency questionnaires (FFQs). The two FFQs evaluated consumption from pre- to early pregnancy and then from early to mid-pregnancy, respectively. Information concerning birth weight was obtained from birth records, and multivariable analyses for birth weight and LBW risk were conducted after adjusting for potential confounders. RESULTS: In total, 17,610 pregnant women (age, 31.8 ± 4.9 years; smoked during pregnancy, 16.1%; gestation period, 38.5 ± 2.5 weeks; first childbirth, 45.5%) and their singleton and term new-borns (birth weight, 3061.8 ± 354.1 g; LBW, 5.4%) were included in the analysis. Women in the highest quartile of grain consumption from pre- to early pregnancy had heavier new-borns (β = 22.3; 95% confidence interval (CI): 5.8-38.9) but did not have a significantly lower LBW risk (odds ratio [OR]: 0.87; 95% CI: 0.71-1.07) than women in the lowest quartile. Women in the highest quartile of grain consumption from early to mid-pregnancy also had heavier new-borns (β = 24.1; 95% CI: 7.1-41.1) but did not have a significantly lower LBW risk (OR: 0.85; 95% CI: 0.69-1.05) than women in the lowest quartile. CONCLUSIONS: Grain consumption before and during pregnancy was positively associated with birth weight.

  294. Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in Japan. International-journal

    Yudai Yonezawa, Fumihiko Ueno, Taku Obara, Takahiro Yamashita, Mami Ishikuro, Keiko Murakami, Aoi Noda, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

    The British journal of nutrition　127　(8)　1-9　2021/06/14

    DOI： 10.1017/S0007114521002154 　

    More details Close

    The association between fruit and vegetable consumption before and during pregnancy and offspring's physical growth has been well reported, but no study has focused on offspring's neurological development. We aimed to explore the association between maternal fruit and vegetable consumption before and during pregnancy and developmental delays in their offspring aged 2 years. Between July 2013 and March 2017, 23 406 women were recruited for the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Fruit and vegetable consumption was calculated using FFQ, and offspring's developmental delays were evaluated by the Ages & Stages Questionnaires, Third Edition (ASQ-3) for infants aged 2 years. Finally, 10 420 women and 10 543 infants were included in the analysis. Totally, 14·9 % of children had developmental delay when screened using the ASQ-3. Women in the highest quartile of vegetable consumption from pre-pregnancy to early pregnancy and from early to mid-pregnancy had lower odds of offspring's developmental delays (OR 0·74; 95 % CI 0·63, 0·89 and OR 0·70; 95 % CI 0·59, 0·84, respectively) than women in the lowest quartile. Women in the highest quartile of fruit consumption from early to mid-pregnancy had lower odds of offspring's developmental delays (OR 0·78; 95 % CI 0·66, 0·92) than women in the lowest quartile. In conclusion, high fruit and vegetable consumption before and during pregnancy was associated with a lower risk of developmental delays in offspring aged 2 years.

  295. Evaluation of the Safety of Taking Lamotrigine During Lactation Period. International-journal

    Kazushi Yashima, Taku Obara, Fumiko Matsuzaki, Chihiro Suzuki, Mika Saeki, Mina Koyama, Moeko Hosono, Aoi Noda, Saya Kikuchi, Tetsuro Hoshiai, Shinichi Sato, Masatoshi Saito, Takushi Hanita, Nariyasu Mano

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine　16　(5)　432-438　2021/05

    DOI： 10.1089/bfm.2020.0210 　

    More details Close

    Introduction: Evaluation of the safety of taking lamotrigine (LTG) during lactation in breastfed infants varies according to the information sources. As it is possible that prescribers may avoid prescribing LTG despite of it being one of the essential drugs, more information needs to be accumulated to facilitate its use. Materials and Methods: We retrospectively compared the safety of LTG during the lactation period in 20 pairs of mothers and infants with 20 pairs as the control group. Results: The mean dose of LTG in 20 mothers was 161.1 mg/day (range: 50-400 mg/day). None of the infants showed a neonatal withdrawal syndrome score of 2 or more up to 1 month after delivery. Although drowsiness (n = 3), skin rash (n = 11), jaundice (n = 8), heart murmur (n = 1), poor suckling (n = 1), and retractive breathing (n = 1) were observed in infants, none of these adverse events were serious and the infants recovered. Nineteen of 20 pairs could continue lactation until 1 month after delivery. One pair discontinued breastfeeding because of pain in the mother's nipples. All pairs could continue maternal medication. We then compared the results with those of the control group. There were no significant differences in the presence of adverse events between the LTG and control groups. Conclusion: These data suggest that taking low to moderate doses of LTG during the lactation period might be relatively safe, at least for a period of 1 month after delivery.

  296. Real-world anticancer medications for reproductive-age women with breast cancer by using a claims database in Japan. International-journal

    Kentaro Tajima, Masami Tsuchiya, Tomofumi Ishikawa, Taku Obara, Nariyasu Mano

    Future oncology (London, England)　17　(15)　1907-1921　2021/05

    DOI： 10.2217/fon-2020-1053 　

    More details Close

    Aim: To describe real-world breast cancer medications among reproductive-age women. Patients & methods: Using data from a Japanese claims database, anticancer prescriptions were classified into seven categories of amenorrhea risk based on fertility preservation guidelines. Results: We identified 2999 women with records of breast cancer and anticancer prescription from 2005 to 2018. The proportions of prescriptions were as follows: high, 4.1-12.9%; intermediate: 6.0-16.3%; low: 0.4-2.3%; very low/no: 0.3-12.2%; unknown: 33.9-45.5%; unlisted combination: 12.2-23.4%; and unlisted drug: 12.5-26.7%. The common drugs in the unknown category were trastuzumab (n = 1527), docetaxel (n = 1014), and paclitaxel (n = 995). For medications unlisted in the guidelines, various drugs and drug combinations were observed. Conclusion: Numerous anticancer drugs are currently being prescribed with insufficient evidence regarding amenorrhea risk.

  297. Factors associated with postpartum smoking relapse among women who quit in early pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

    Journal of epidemiology　33　(1)　8-14　2021/04/28

    DOI： 10.2188/jea.JE20200609 　

    More details Close

    BACKGROUND: While a wide range of predictors of postpartum smoking relapse have been suggested, population-based studies have rarely examined these factors exclusively among women who quit in early pregnancy. Furthermore, workplace secondhand smoke (SHS) exposure has never been examined. METHODS: We analyzed data from 10,466 pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Age, education, parity, breastfeeding, postpartum depression, SHS exposure at home, and SHS exposure at work (not working, working without SHS exposure, working with SHS exposure) were evaluated as possible predictors. Multiple logistic regression analyses were conducted to examine the associations between these factors and smoking relapse by 1 year postpartum among women who quit in early pregnancy. Analyses stratified by SHS exposure at home were also conducted. RESULTS: About one-fourth of early-pregnancy quitters had relapsed into smoking by 1 year postpartum. Lower education, multiparity, not breastfeeding, postpartum depression, and SHS exposure at home were associated with increased risks of smoking relapse. Working with SHS exposure was associated with an increased risk of smoking relapse; the multivariate-adjusted odds ratios (95% confidence intervals) of working without SHS exposure and working with SHS exposure compared with not working were 1.14 (0.82-1.59) and 2.18 (1.37-3.46), respectively. The significant association of workplace SHS exposure was observed only among women without SHS exposure at home. CONCLUSIONS: SHS exposure at work, as well as education, multiparity, breastfeeding, postpartum depression, and SHS exposure at home were associated with postpartum smoking relapse among early-pregnancy quitters.

  298. High-quality reports and their characteristics in the Japanese Adverse Drug Event Report database (JADER)

    Masami Tsuchiya, Taku Obara, Makoto Miyazaki, Aoi Noda, Takamasa Sakai, Ryohkan Funakoshi, Nariyasu Mano

    Journal of Pharmacy & Pharmaceutical Sciences　24　161-173　2021/04/08

    Publisher: University of Alberta Libraries

    DOI： 10.18433/jpps31417 　

    eISSN： 1482-1826

    More details Close

    Purpose: Spontaneous adverse drug reaction reporting is the foundation of postmarketing drug safety monitoring. The present study aimed to analyze and clarify the quality and characteristics of the Japanese Adverse Drug Event Report database (JADER) using the World Health Organization (WHO) documentation grading scheme and the vigiGrade completeness score. The characteristics of reports were described using both schemes simultaneously. The way of proper use of these two schemes was explored. Methods: The WHO documentation grading scheme and the vigiGrade completeness score were applied to the same dataset (JADER202001 dataset). Reports classified as high-quality under both assessment criteria were extracted, and the characteristics of these reports were analyzed. Results: Of the 607,361 adverse drug reaction reports analyzed, 52.8% were ‘well-documented reports’ with a vigiGrade completeness score &gt;0.8. Under the WHO documentation grading scheme, 328,702 reports (54.1%) were Grade 2 and 5,178 (0.9%) were Grade 3 (including rechallenge information). Among well-documented Grade 3 reports, classified as the highest quality, a high proportion of the adverse drug reaction reports were related to disorders of hematopoietic function resulting from anticancer drugs. Because a high proportion of the reports with rechallenge information were for anticancer drugs as suspect drugs, the WHO documentation grading scheme tended to extract reports regarding anticancer drugs as high quality. Conclusions: We conclude that the two schemes need to be used appropriately, depending on the purpose of analysis, the target adverse drug reactions, and suspect drugs.

  299. The impact of regulation changes in the spontaneous reporting system for vaccines on reporting trends and signal detection in Japan. International-journal

    Makoto Miyazaki, Takamasa Sakai, Taku Obara, Nariyasu Mano

    Pharmacoepidemiology and drug safety　30　(8)　1091-1100　2021/03/17

    DOI： 10.1002/pds.5231 　

    More details Close

    PURPOSE: Spontaneous reporting constitutes one of the most fundamental and important systems for pharmacovigilance. In Japan, important regulation changes in the vaccine spontaneous reporting were implemented between 2009 and 2013; however, no studies had yet assessed the impact of the changes. The objective of this study was to assess the impact on the reporting trends in vaccine reports and on signal detection for vaccines. METHODS: For assessment of the impact on the reporting trends, we performed the joinpoint trend analysis and descriptively considered number of vaccine reports grouped by the timing of the regulation change. For assessment of the impact on signal detection, we performed signal detection using dataset during the pre or postperiod of the regulation changes, and compared their agreement rates, which was calculated with a reference set for vaccines, created by the Global Research in Paediatrics project. RESULTS: We retrieved 467 635 spontaneous reports, including 12 287 vaccine reports from April 2004 to March 2019. The average number of vaccine reports per year increased from 231 reports during the preperiod to 1227 during the postperiod. The joinpoint trend analysis found two joinpoints and differentiated three trends, significant increased trend of which was observed when regulations had changed. For signal detection, the agreement rate was improved when using data during the postperiod. CONCLUSION: We concluded that the regulation changes increased the number of vaccine reports, and could have improved signal detection performance for vaccines by accelerating accumulation of reports, while more spontaneous reports are necessary to optimize signal detection.

  300. 危機管理計画に基づく医薬品副作用モニタリングシステムの実施(Implementation of an Adverse Drug Reaction Monitoring System Based on Risk Management Plans)

    Tsuchiya Masami, Esashi Akihisa, Obara Taku, Funakoshi Ryohkan, Mano Nariyasu

    医薬品相互作用研究　45　(1)　19-26　2021/03

    Publisher: (一社)医薬品相互作用研究会

    ISSN： 0385-5015

  301. Maternal personality and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Fumihiko Ueno, Ibuki Nakamura, Mami Ishikuro, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

    Journal of affective disorders　282　580-586　2021/03/01

    DOI： 10.1016/j.jad.2020.12.187 　

    More details Close

    BACKGROUND: Despite much knowledge of the effects of maternal psychopathology on bonding, the effects of personality have received less attention. We aimed to examine the association between maternal personality and postnatal bonding disorder. METHODS: We analyzed data from 15,654 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised, with the score for each subscale categorized into four levels. Bonding disorder was defined as the Mother-to-Infant Bonding Scale score of ≥5 one month after delivery. Multiple logistic regression analyses were conducted to examine the association between personality and bonding disorder after adjusting for age, education, parity, feelings towards pregnancy, social isolation, as well as the Edinburgh Postpartum Depression Scale (EPDS) score. RESULTS: Higher extraversion was associated with a decreased risk of bonding disorder (p for trend <0.001). Higher neuroticism was associated with an increased risk of bonding disorder (p for trend <0.001), and this association disappeared after further adjustment for EPDS score (p for trend 0.39). No association between psychoticism and bonding disorder was observed (p for trend 0.83), and the association appeared after further adjustment for EPDS score (p for trend 0.0017). Higher lie was associated with a decreased risk of bonding disorder (p for trend <0.001). LIMITATIONS: Maternal personality and bonding were self-reported. CONCLUSIONS: Lower extraversion, higher psychoticism, and lower lie were associated with bonding disorder. The association between higher neuroticism and bonding disorder was explained by postnatal depressive symptoms.

  302. The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake. International-journal

    Kaou Tanoue, Zen Watanabe, Hidekazu Nishigori, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Kousuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Environmental health and preventive medicine　26　(1)　27-27　2021/02/26

    DOI： 10.1186/s12199-021-00944-2 　

    More details Close

    BACKGROUND: To examine changes in psychological distress prevalence among pregnant women in Miyagi Prefecture, which was directly affected by the Great East Japan Earthquake and tsunami, and compare it with the other, less damaged areas of Japan. METHODS: This study was conducted in conjunction with the Japan Environment and Children`s Study. We examined 76,152 pregnant women including 8270 in Miyagi Regional Center and 67,882 in 13 other regional centers from the all-birth fixed data of the Japan Environment and Children's Study. We then compared the prevalence and risk of distress in women in Miyagi Regional Center and women in the 13 regional centers for 3 years after the disaster. RESULTS: Women in the Miyagi Regional Center suffered more psychological distress than those in the 13 regional centers: OR 1.38 (95% CI, 1.03-1.87) to 1.92 (95% CI, 1.42-2.60). Additionally, women in the inland area had a consistently higher prevalence of psychological distress compared to those from the 13 regional centers: OR 1.67 (95% CI, 1.18-2.38) to 2.19 (95% CI, 1.60-2.99). CONCLUSIONS: The lack of pre-disaster data in the Japan Environment and Children's Study made it impossible to compare the incidence of psychological distress before and after the March 2011 Great East Japan Earthquake. However, 3 years after the Great East Japan Earthquake, the prevalence of pregnant women with psychological distress did not improve in Miyagi Regional Center. Further, the prevalence of mental illness in inland areas was consistently higher than that in the 13 regional centers after the disaster.

  303. 後期早産児の乳幼児期における精神運動発達の縦断的推移

    小林 美佳, 石黒 真美, 大沼 ともみ, 村上 慶子, 上野 史彦, 野田 あおい, 小林 朋子, 小原 拓, 呉 繁夫, 栗山 進一

    Journal of Epidemiology　31　(Suppl.1)　89-89　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  304. 親子間の心電図波形の関連 東北メディカル・バンク計画三世代コホート調査

    中嶋 伸吾, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 小原 拓, 栗山 進一

    Journal of Epidemiology　31　(Suppl.1)　96-96　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  305. 全国大学医学部における医薬品・医療機器等安全性情報報告制度に関わる授業内容の実態

    佐藤 倫広, 目時 弘仁, 堀 里子, 小原 拓, 眞野 成康

    日本臨床薬理学会学術総会抄録集　42　2-P-O-3　2021

    Publisher: 一般社団法人 日本臨床薬理学会

    DOI： 10.50993/jsptsuppl.42.0_2-p-o-3 　

    eISSN： 2436-5580

    More details Close

    【目的】医薬品・医療機器等安全性情報報告制度（以下、本制度）により、医薬関係者は医薬品等によって発生する健康被害等の情報を厚生労働大臣に報告することとされている。全ての医療機関及び薬局等が対象であるが、医薬品の国内副作用・感染症症例報告に占める医療機関報告は少ない。本制度の理解度が副作用等報告の経験に強く関連するという先行研究から、大学生時代における教育が重要と考えられるが、医学部における教育実態は明らかではない。本研究では、全国の医学部を有する大学を対象に、本制度に関わる授業を明らかにすることを目的とした。 【方法】本研究は、医薬品等規制調和・評価研究事業（AMED）『医薬関係者による副作用報告の質向上に向けた情報連携のあり方の研究（代表：眞野成康）』の一環として実施された。全国の医学部を有する大学に、電話、メール、ホームページからの問い合わせ、または紙媒体の郵送により調査を依頼し、本制度に関わる授業科目とその内容、および自由記載により本制度の医学教育における改善点と意見を収集した。 【結果・考察】全82大学のうち25大学から当該授業科目の内容が回答された。その他、11大学から該当する授業がない旨の回答、4大学から回答拒否、および42大学からは未回答（現在郵送調査による再依頼中）であった。本制度に関わる講義をした科目は、薬理学が9件、臨床薬理学・薬物治療学が8件、衛生学・公衆衛生学が5件、医療安全・管理学が5件と多く、概論や実習を含むその他25件の科目も挙げられた。これら授業のコマ数を各大学で集計した結果、授業コマ数は1～2コマが17大学と最も多かった。履修学年は4年次が最も多く、5年次以上で回答された科目を実施している大学は3大学のみであった。医薬品安全性情報報告書を実際に「記載させる」と回答した科目は1件のみであった。意見の自由記載欄では、副作用発生の臨床薬理学的なバックグラウンドや薬害歴史の理解の重要性に言及した回答が比較的多く見られ、その他、報告に関わる実習の増加、医学部コアカリキュラムの改定、または5～6年や卒後の教育の充実などが具体的な提案として挙げられた。 【結論】医学部における本制度の講義は、主に薬理学および臨床薬理学・薬物治療学で実施されていた。実際に報告を経験させる授業は限られており、また、5～6年次における授業も不十分と考えられた。

  306. Heart Rate Information-Based Machine Learning Prediction of Emotions Among Pregnant Women. International-journal

    Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

    Frontiers in psychiatry　12　799029-799029　2021

    DOI： 10.3389/fpsyt.2021.799029 　

    More details Close

    In this study, the extent to which different emotions of pregnant women can be predicted based on heart rate-relevant information as indicators of autonomic nervous system functioning was explored using various machine learning algorithms. Nine heart rate-relevant autonomic system indicators, including the coefficient of variation R-R interval (CVRR), standard deviation of all NN intervals (SDNN), and square root of the mean squared differences of successive NN intervals (RMSSD), were measured using a heart rate monitor (MyBeat) and four different emotions including "happy," as a positive emotion and "anxiety," "sad," "frustrated," as negative emotions were self-recorded on a smartphone application, during 1 week starting from 23rd to 32nd weeks of pregnancy from 85 pregnant women. The k-nearest neighbor (k-NN), support vector machine (SVM), logistic regression (LR), random forest (RF), naïve bayes (NB), decision tree (DT), gradient boosting trees (GBT), stochastic gradient descent (SGD), extreme gradient boosting (XGBoost), and artificial neural network (ANN) machine learning methods were applied to predict the four different emotions based on the heart rate-relevant information. To predict four different emotions, RF also showed a modest area under the receiver operating characteristic curve (AUC-ROC) of 0.70. CVRR, RMSSD, SDNN, high frequency (HF), and low frequency (LF) mostly contributed to the predictions. GBT displayed the second highest AUC (0.69). Comprehensive analyses revealed the benefits of the prediction accuracy of the RF and GBT methods and were beneficial to establish models to predict emotions based on autonomic nervous system indicators. The results implicated SDNN, RMSSD, CVRR, LF, and HF as important parameters for the predictions.

  307. Prescription of Kampo Formulations for Pre-natal and Post-partum Women in Japan: Data From an Administrative Health Database. International-journal

    Satoko Suzuki, Taku Obara, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Ryutaro Arita, Minoru Ohsawa, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

    Frontiers in nutrition　8　762895-762895　2021

    DOI： 10.3389/fnut.2021.762895 　

    More details Close

    Introduction: Traditional Japanese (Kampo) medicines are often prescribed for women in Japan before, during, and after pregnancy. However, detailed information on the actual frequency of use and safety of Kampo preparations during pregnancy is lacking. Aim: To investigate the frequency of prescription of Kampo medicines for pregnant women in Japan. Methods: Information on Kampo medicines prescribed during outpatient care and hospitalization of selected mothers from January 2005 to August 2016 were extracted from the Japan Medical Data Center (Tokyo, Japan), which is a large claims database. Results: Of the 33,941 subscribers identified from the database, 16,294 (48%) received at least one prescription of a Kampo medicine. Kakkonto was the formula most prescribed during the study period, followed by shoseiryuto and tokishakuyakusan. In the 180 days before pregnancy, the most prescribed medicine was tokishakuyakusan, followed by kakkonto and shoseiryuto. Shoseiryuto, tokishakuyakusan, and kakkonnto were the formulae most prescribed during pregnancy. The most prescribed medicines during the 180 days postpartum were kakkonto, shoseiryuto, and saireito. Conclusions: Information in the Japanese insurance system shows that Kampo medicines are often prescribed during pregnancy. Most of these prescriptions are generally used for the treatment of common cold. Tokishakuyakusan in particular is usually used in the treatment of various symptoms of pregnancy. Further research is needed to clarify the relationship between the use of Kampo medicines during pregnancy and adverse events in infants in Japan.

  308. 児の先天奇形に関するレセプト傷病名の妥当性評価

    石川 智史, 小原 拓, 大柳 元, 野田 あおい, 森下 啓, 高木 秀侑, 井上 隆輔, 川目 裕, 眞野 成康

    Journal of Epidemiology　31　(Suppl.)　131-131　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  309. 両親と児の血圧値の関連についての横断的検討 三世代コホート調査

    石黒 真美, 小原 拓, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 目時 弘仁, 菊谷 昌浩, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　101-101　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  310. 東北メディカル・メガバンク計画三世代コホート調査の進捗

    小原 拓, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　105-105　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  311. 妊娠前および妊娠中の穀物摂取量と出生時体重・低出生体重 三世代コホート調査

    米沢 祐大, 小原 拓, 山下 貴宏, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 菅原 準一, 鈴木 重徳, 菅沼 大行, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　95-95　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  312. 東北メディカル・メガバンク計画地域住民コホート 特定健診共同参加型対象者の基礎特性とがん罹患の関連

    寳澤 篤, 小原 拓, 中村 智洋, 板橋 芙美, 小暮 真奈, 成田 暁, 土屋 菜歩, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 布施 昇男, 辻 一郎, 呉 繁夫

    Journal of Epidemiology　31　(Suppl.)　116-116　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  313. Small for gestational age児を予測するリスクスコアの検討 三世代コホート調査

    岩間 憲之, 小原 拓, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 星合 哲郎, 齋藤 昌利, 目時 弘仁, 菅原 準一, 八重樫 伸生, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　130-130　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  314. 東北メディカル・メガバンク計画三世代コホート調査 母子のベースライン調査プロファイル

    菅原 準一, 石黒 真美, 大沼 ともみ, 村上 慶子, 上野 史彦, 野田 あおい, 菊谷 昌浩, 目時 弘仁, 小原 拓, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　131-131　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  315. Active Extraction of Experience of Adverse Drug Reactions in Children. International-journal

    Aoi Noda, Taku Obara, Michihiro Satoh, Naoto Yagi, Nariyasu Mano, Kenji Kaneko

    The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG　26　(4)　352-360　2021

    DOI： 10.5863/1551-6776-26.4.352 　

    More details Close

    OBJECTIVE: Safety information regarding the use of medication, over-the-counter drugs, and supplements for Japanese children is scarce. The aim of this study was to clarify adverse drug reaction (ADR) experiences in children and consider the method to collect ADRs efficiently. METHODS: We conducted a questionnaire survey regarding the ADR experiences of 20,412 children who were attending a preschool or kindergarten in the cities of Warabi and Toda, Saitama Prefecture, in May 2013. RESULTS: Responses were received from the guardians of 15,076 children (49.5% girls; 8.2 ± 3.5 yr). A total of 196 guardians (1.3%) responded that their children had experienced ADRs. Among them, a total of 243 suspected drugs and 284 ADRs were reported. Of the 243 suspected drugs, 2.5% were associated with a vaccine. The most frequently reported medication, reaction, and "medication-reaction pair" were antibacterials for systemic use, rash, and "antibacterials for systemic use and rash," respectively. CONCLUSIONS: In this study, we clarified that there were many potential ADRs among children, but all "medication-reaction pairs" reported were consistent with adverse events reported in the clinical trials available in the prescribing information of each medication. This study provides data respective to the frequency of these adverse events in the general pediatric population. Additional education is needed to enlighten guardians of the importance to report ADRs through the Direct Patient Reporting System.

  316. 妊娠前および妊娠中の穀物摂取量と出生時体重・低出生体重 三世代コホート調査

    米沢 祐大, 小原 拓, 山下 貴宏, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 菅原 準一, 鈴木 重徳, 菅沼 大行, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　95-95　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  317. 東北メディカル・メガバンク計画地域住民コホート 特定健診共同参加型対象者の基礎特性とがん罹患の関連

    寳澤 篤, 小原 拓, 中村 智洋, 板橋 芙美, 小暮 真奈, 成田 暁, 土屋 菜歩, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 布施 昇男, 辻 一郎, 呉 繁夫

    Journal of Epidemiology　31　(Suppl.)　116-116　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  318. Small for gestational age児を予測するリスクスコアの検討 三世代コホート調査

    岩間 憲之, 小原 拓, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 星合 哲郎, 齋藤 昌利, 目時 弘仁, 菅原 準一, 八重樫 伸生, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　130-130　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  319. 東北メディカル・メガバンク計画三世代コホート調査 母子のベースライン調査プロファイル

    菅原 準一, 石黒 真美, 大沼 ともみ, 村上 慶子, 上野 史彦, 野田 あおい, 菊谷 昌浩, 目時 弘仁, 小原 拓, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　131-131　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  320. 児の先天奇形に関するレセプト傷病名の妥当性評価

    石川 智史, 小原 拓, 大柳 元, 野田 あおい, 森下 啓, 高木 秀侑, 井上 隆輔, 川目 裕, 眞野 成康

    Journal of Epidemiology　31　(Suppl.)　131-131　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  321. Adverse Drug Reaction Reports Regarding Abnormal Behavior After Oseltamivir Use in Children as Reported by Consumers or Healthcare Professionals. International-journal

    Aoi Noda, Masami Tsuchiya, Takamasa Sakai, Taku Obara, Nariyasu Mano

    Patient preference and adherence　15　533-541　2021

    DOI： 10.2147/PPA.S292072 　

    More details Close

    Purpose: The purpose of this study was to assess the differences between consumer (patient) and healthcare professional submissions of adverse drug reaction (ADR) reports associated with certain antiviral treatments in children. Material and Methods: We extracted ADR reports for children aged <20 years who received oseltamivir or similar drugs (zanamivir and amantadine) between April 2004 and May 2020 from the Japanese Adverse Drug Event Report database. Abnormal behavior after oseltamivir administration was reported frequently in the news in November 2005, and a Dear Healthcare Professional letter about abnormal behavior after oseltamivir use was issued on March 20, 2007. We compared the number of ADR reports by three periods: (1) before the news, (2) between the news and the letter, and (3) after the letter. These reports were tabulated and analyzed after stratification according to the reporter (healthcare professionals only, patients and healthcare professionals, patients only), patient age (<10 years, 10-19 years), and ADR (abnormal behavior, other ADRs). Results: For the reports from healthcare professionals only, the number of reports per quarter associated with oseltamivir was largest during the period between the news about abnormal behavior after oseltamivir use and publication of the Dear Healthcare Professional letter. The reports from patients only about abnormal behavior after oseltamivir use were first reported after publication of the letter. The proportions of reports from patients only about abnormal behavior with oseltamivir were 81.0% and 92.2% for ages <10 and 10-19 years, respectively. A ripple effect of increasing reports was observed with zanamivir or amantadine. Conclusion: Reports from patients only might increase in response to the media more than reports from healthcare professionals only or patients and healthcare professionals do. The ADR reports from patients must be carefully assessed from the perspective of when they were reported.

  322. Drug Prescription for Attention Deficit Hyperactivity Disorder Drugs in Pediatric Outpatients: A Retrospective Survey of Japanese Administrative Data (2012–2018)

    Daisuke Kikuchi, Taku Obara, Misaki Tokunaga, Makoto Shiozawa, Ai Takahashi, Misato Ito, Hiroaki Hino, Ryosuke Miura, Sachiko Hayakawa, Yoshiteru Watanabe

    Asian Journal of Psychiatry　102512-102512　2021/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.ajp.2020.102512 　

    ISSN： 1876-2018

  323. Clustering by phenotype and genome-wide association study in autism Peer-reviewed

    Akira Narita, Masato Nagai, Satoshi Mizuno, Soichi Ogishima, Gen Tamiya, Masao Ueki, Rieko Sakurai, Satoshi Makino, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Hiroko Matsubara, Yasutaka Kuniyoshi, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomoko Kobayashi, Mika Kobayashi, Takuma Usuzaki, Hisashi Ohseto, Atsushi Hozawa, Masahiro Kikuya, Hirohito Metoki, Shigeo Kure, Shinichi Kuriyama

    Translational Psychiatry　10　(1)　2020/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41398-020-00951-x 　

    eISSN： 2158-3188

    More details Close

    <title>Abstract</title>Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have more power to elucidate hidden heritability. We conducted cluster analyses using the k-means algorithm with a cluster number of 15 based on phenotypic variables from the Simons Simplex Collection (SSC). As a preliminary study, we conducted a conventional genome-wide association study (GWAS) with a data set of 597 ASD cases and 370 controls. In the second step, we divided cases based on the clustering results and conducted GWAS in each of the subgroups vs controls (cluster-based GWAS). We also conducted cluster-based GWAS on another SSC data set of 712 probands and 354 controls in the replication stage. In the preliminary study, which was conducted in conventional GWAS design, we observed no significant associations. In the second step of cluster-based GWASs, we identified 65 chromosomal loci, which included 30 intragenic loci located in 21 genes and 35 intergenic loci that satisfied the threshold of <italic>P</italic> &lt; 5.0 × 10−8. Some of these loci were located within or near previously reported candidate genes for ASD: <italic>CDH5</italic>, <italic>CNTN5, CNTNAP5, DNAH17, DPP10, DSCAM</italic>, <italic>FOXK1</italic>, <italic>GABBR2, GRIN2A</italic>5, <italic>ITPR1, NTM, SDK1, SNCA</italic>, and <italic>SRRM4</italic>. Of these 65 significant chromosomal loci, rs11064685 located within the <italic>SRRM4</italic> gene had a significantly different distribution in the cases vs controls in the replication cohort. These findings suggest that clustering may successfully identify subgroups with relatively homogeneous disease etiologies. Further cluster validation and replication studies are warranted in larger cohorts.

  324. Commentary on “Determinants of pre‐eclampsia among pregnant women attending perinatal care in hospitals of the Omo district, Southern Ethiopia”

    Takuma Usuzaki, Mami Ishikuro, Taku Obara

    The Journal of Clinical Hypertension　23　(1)　163-165　2020/11/21

    Publisher: Wiley

    DOI： 10.1111/jch.14110 　

    ISSN： 1524-6175

    eISSN： 1751-7176

  325. Comparison among research, home, and office blood pressure measurements for pregnant women: The TMM BirThree Cohort Study. International-journal

    Takuma Usuzaki, Mami Ishikuro, Hirohito Metoki, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Masahiro Kikuya, Taku Obara, Shinichi Kuriyama

    Journal of clinical hypertension (Greenwich, Conn.)　22　(11)　2004-2013　2020/11

    DOI： 10.1111/jch.14050 　

    More details Close

    Blood pressure (BP) measurements of pregnant women have been collected in offices and at home for previous research. However, it remains uncertain whether there is difference between research BP, defined as BP measured for the purpose of epidemiological research and BP measured at home or in an office. Therefore, the present study aimed to compare research BP with home and unstandardized office BP. Research, home, and office BP were measured among pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). Research BP was measured twice at our research center while the participant was seated and after resting for 1-2 minutes. Research, home, and office BP were compared and agreement among the values was assessed. Differences among research, home, and office BP values and possible factors affecting differences were analyzed. Among 656 pregnant women, the mean (± standard deviations) research systolic (S), diastolic (D) BP, home SBP, home DBP office SBP, and office DBP were 103.8 ± 8.5, 61.8 ± 7.3, 104.4 ± 9.2, 61.2 ± 6.8, 110.5 ± 10.8, and 63.8 ± 8.7mmHg, respectively. Research SBP value was lower than home value (P = .0072; difference between mean research and home BP: -0.61 ± 7.8 mmHg). Research SBP and DBP values were lower than office values (P < .0001 for both SBP and DBP; means ± standard deviations of differences between research and office BP: 6.7 ± 10.1 and 2.0 ± 8.5 mmHg for SBP and DBP, respectively). In conclusion, when research BP is measured under conditions controlled, research BP can give close values to home BP for pregnant women.

  326. Associations between glycosylated hemoglobin level at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan: The Japan Environment and Children's Study (JECS). International-journal

    Noriyuki Iwama, Takashi Sugiyama, Hirohito Metoki, Masatoshi Saito, Tetsuro Hoshiai, Zen Watanabe, Kosuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hidekazu Nishigori, Shin-Ichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Diabetes research and clinical practice　169　108377-108377　2020/11

    DOI： 10.1016/j.diabres.2020.108377 　

    More details Close

    AIMS: To investigate the associations between glycosylated hemoglobin (HbA1c) levels at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan. METHODS: This was a prospective nationwide birth cohort study of 77,526 subjects with an HbA1c level of <6.5% (<48 mmol/mol) at less than 24 weeks of gestation. Associations of HbA1c level with adverse pregnancy outcomes were evaluated using multivariate analyses. RESULTS: The adjusted odds ratios per 1% (11 mmol/mol) increase in HbA1c level were 1.77 (95% confidence interval [CI]: 1.48-2.12) for hypertensive disorders of pregnancy; 1.78 (95% CI: 1.12-2.83) for placental abruption; 1.30 (95% CI: 1.12-1.50) for preterm birth; 2.11 (95% CI: 1.41-3.16) for very preterm birth; 1.49 (95% CI: 1.33-1.68) for low birth weight infants; 1.95 (95% CI: 1.42-2.70) for macrosomia; 1.23 (95% CI: 1.09-1.39) for small for gestational age; 1.15 (95% CI: 1.04-1.28) for large for gestational age; and 1.29 (95% CI: 1.20-1.39) for the composite adverse pregnancy outcome. CONCLUSIONS: The higher the HbA1c level, the higher the risk of adverse pregnancy outcomes in Japan. Further studies will be needed to determine prenatal management based on the HbA1c level in pregnant women with HbA1c <6.5% (<48 mmol/mol) at less than 24 weeks of gestation.

  327. Maternal Baseline Characteristics and Perinatal Outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Junichi Sugawara, Mami Ishikuro, Taku Obara, Tomomi Onuma, Keiko Murakami, Masahiro Kikuya, Fumihiko Ueno, Aoi Noda, Satoshi Mizuno, Tomoko Kobayashi, Yohei Hamanaka, Kichiya Suzuki, Eiichi Kodama, Naho Tsuchiya, Akira Uruno, Yoichi Suzuki, Osamu Tanabe, Hideyasu Kiyomoto, Akito Tsuboi, Atsushi Shimizu, Seizo Koshiba, Naoko Minegishi, Soichi Ogishima, Gen Tamiya, Hirohito Metoki, Atsushi Hozawa, Nobuo Fuse, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology　32　(2)　69-79　2020/10/10

    DOI： 10.2188/jea.JE20200338 　

    More details Close

    BACKGROUND: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants. METHODS: Expectant mothers living in Miyagi prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group. RESULTS: A total of 23 406 pregnancies involving 23 730 fetuses resulted in 23 143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes and hypertensive disorders of pregnancy. CONCLUSIONS: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.

  328. Social predictors of continued and indoor smoking among partners of non-smoking pregnant women: the TMM BirThree Cohort Study.

    Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

    Journal of epidemiology　31　(12)　635-641　2020/09/19

    DOI： 10.2188/jea.JE20200313 　

    More details Close

    BACKGROUND: Secondhand smoke (SHS) from partners is a major source of exposure for non-smoking women. However, epidemiological studies have rarely examined social factors associated with continued and indoor smoking among pregnant women's partners. METHODS: We analyzed data on 6091 partners of non-smoking pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Partners' age, education, income, workplace SHS exposure (almost never or sometimes, almost every day), and pregnant women's smoking history (never, quit before pregnancy awareness, quit after pregnancy awareness) were used as social factors. Multivariate logistic regression analyses were conducted to examine the associations of social factors with partners' continued smoking and indoor smoking. RESULTS: Among 2432 smoking partners, 2237 continued to smoke after pregnancy awareness. Workplace SHS exposure was associated with increased risk of partners' continued smoking: the odds ratio of workplace SHS exposure almost every day compared with almost never or sometimes was 2.08 (95% confidence interval, 1.52-2.83). Women's quitting smoking after-but not before-pregnancy awareness was associated with decreased risk of partners' continued smoking: the odds ratio of women's quitting after pregnancy awareness compared with never smoking was 0.57 (95% confidence interval, 0.40-0.80). About one-third of partners who continued to smoke did so indoors. Older age, lower education, workplace SHS exposure, and women's quitting smoking after pregnancy awareness were associated with increased risk of partners' indoor smoking. CONCLUSIONS: Workplace SHS exposure and pregnant women's smoking history were associated with continued smoking and indoor smoking among partners of non-smoking pregnant women.

  329. Associations of Education and Income With Secondhand Smoke Exposure Among Non-Smoking Pregnant Women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

    Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

    2020/09/03

    Publisher: Research Square

    DOI： 10.21203/rs.3.rs-64032/v1 　

    More details Close

    <title>Abstract</title> <bold>Background:</bold> Associations of education and income with secondhand smoke (SHS) exposure have been well documented in the general population. However, evidence among non-smoking pregnant women is limited, including in Japan. The purpose of the study was to examine the associations of education and income with SHS exposure among non-smoking pregnant women in Japan.<bold>Methods:</bold> We analyzed data from 17815 non-smoking pregnant women in Japan who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. SHS exposure was defined as indoor exposure to someone else’s cigarette smoke ≥1 day/week during pregnancy. Multiple logistic regression analyses were conducted to examine whether pregnant women’s educational attainment or equivalent household income was associated with SHS exposure, adjusting for age, work status, smoking history, partners’ education, and income/education. Stratified analyses by work status were also conducted.<bold>Results:</bold> The prevalence of SHS exposure during pregnancy was 34.0%; 29.4% among non-working women and 37.1% among working women. Lower educational attainment was associated with an increased risk of SHS exposure; the odds ratio of high school education or lower compared with university education or higher was 1.78 (95% confidence interval, 1.59–1.99). Lower equivalent household income was associated with an increased risk of SHS exposure; the odds ratio of the lowest compared with the highest level of income was 1.67 (95% confidence interval, 1.51–1.84). These associations did not differ between non-working women and working women.<bold>Conclusions:</bold> Pregnant women with lower education and/or lower household income had higher risks of SHS exposure in Japan. These findings imply that educational interventions and financial incentives are needed for pregnant women and their household smokers in helping to reduce SHS exposure among non-smoking pregnant women.

  330. 臨床試験論文の利用に関する薬剤師の実態調査

    石井 勇太, 中川 直人, 小原 拓, 大原 宏司, 栗田 幸代, 村井 ユリ子

    薬学雑誌　140　(9)　1195-1198　2020/09

    Publisher: (公社)日本薬学会

    ISSN： 0031-6903

    eISSN： 1347-5231

    More details Close

    2014年度における臨床試験の論文読解に関するわが国の薬剤師の実情を報告した。宮城県内の薬剤師605人から得られた調査票の回答から解析を行った結果、臨床試験の論文を読むことの必要性は多くの病院薬剤師(85.8%)及び薬局薬剤師(74.4%)が感じていたが、その習慣を持っている病院薬剤師は19.5%、薬局薬剤師は8.3%であった。臨床試験の論文を読む習慣があまりない理由として「読む時間がない」「英語の問題」が挙げられたほか、臨床試験の論文の批判的な読み方を大学で学ぶ機会がなく、そのスキルが備わっていないことや、論文アクセスを取り巻く環境が不十分である実情が明らかとなった。本調査研究で抽出されたこれらの諸問題の改善策として、臨床試験の論文を批判的に吟味するスモールグループ形式の研修会開催や、学術論文を自由に検索・取得できる環境の整備が考えられた。

  331. 【周産期メンタルヘルスの今】東北メディカル・メガバンク事業出生コホートを起点とした産後うつ病研究

    菊地 紗耶, 小林 奈津子, 小野 千晶, 割田 紀子, 村上 慶子, 小原 拓, 長神 風二, 栗山 進一, 富田 博秋

    精神医学　62　(9)　1245-1251　2020/09

    Publisher: (株)医学書院

    ISSN： 0488-1281

    eISSN： 1882-126X

  332. How can we evaluate whether an association is truly inter-generational? International-journal

    Takuma Usuzaki, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Taku Obara, Shinichi Kuriyama

    Journal of hypertension　38　(9)　1866-1868　2020/09

    DOI： 10.1097/HJH.0000000000002507 　

  333. Survey on the Pharmacists Perceptions of Clinical Trial Literature Accessibility

    Yuta Ishii, Naoto Nakagawa, Taku Obara, Hiroshi Ohara, Sachiyo Kurita, Yuriko Murai

    YAKUGAKU ZASSHI　140　(9)　1195-1198　2020/09/01

    Publisher: Pharmaceutical Society of Japan

    DOI： 10.1248/yakushi.20-00009 　

    ISSN： 0031-6903

    eISSN： 1347-5231

  334. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. International-journal Peer-reviewed

    Maiko Wagata, Mami Ishikuro, Taku Obara, Masato Nagai, Satoshi Mizuno, Naoki Nakaya, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Hirohito Metoki, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama, Junichi Sugawara

    Pregnancy hypertension　22　119-125　2020/08/05

    DOI： 10.1016/j.preghy.2020.08.001 　

    More details Close

    Low birth weight is known to be associated with hypertension, cardiovascular disease and hypertensive disorders of pregnancy (HDP); however, this association might vary by race/ethnicity. This study aimed to clarify the association between women's own birth weight and their subsequent risk for HDP in a Japanese population, in combination with pre-pregnancy body mass index (BMI). We conducted a cohort study as part of the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Miyagi, Japan. Our study's population included 4810 women. A multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (aOR) and the 95% confidence interval (CI) of the women's own birth weight for HDP, in the combination categories of birth weight and pre-pregnancy BMI. As a result, the group with a low birth weight of <2500 g had a significant association with HDP (the aOR, 1.50; 95% CI, 1.02-2.21). In the subtype analysis, the odds ratio for only preeclampsia was significantly increased in the low birth weight group (aOR, 3.37; 95% CI, 1.84-6.16). In the group with a low birth weight, the prevalence of HDP was higher in both the underweight and overweight groups. In conclusion, there was a significant association between low birth weight and subsequent HDP in Japanese women. Furthermore, a significant association with HDP was found for women born with a low birth weight who were underweight or overweight as adults. Maintaining a normal weight may be effective for preventing HDP even if a woman was born small.

  335. Fruit and vegetable consumption before and during pregnancy and birth weight of new-borns in Japan: the Tohoku medical megabank project birth and three-generation cohort study. International-journal Peer-reviewed

    Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Junichi Sugawara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

    Nutrition journal　19　(1)　80-80　2020/08/03

    DOI： 10.1186/s12937-020-00595-z 　

    More details Close

    BACKGROUND: Associations of fruit and vegetable consumption before and during pregnancy with birth weight of new-borns and the risk of low birth weight (LBW) remain unclear. METHODS: Between July 2013 and March 2017, we recruited 23,406 pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). Fruit and vegetable consumption before and during pregnancy was calculated using food frequency questionnaires. Information regarding birth weight was obtained from medical records, and LBW was defined as < 2500 g. We used a multivariable linear regression model and a multivariate logistic regression model to assess associations between fruit and vegetable consumption and birth weight/risk of LBW. RESULTS: In total, 17,610 women were included in the analysis. Mean birth weight was 3061.8 ± 354.1 g, and 5.4% of the new-borns had LBW. Compared to women in the lowest quartile of fruit consumption between pre- and early pregnancy, women in the highest quartile had heavier new-borns (β = 49.4; 95% CI: 34.1-64.7) and lower risk of LBW (OR: 0.79; 95% CI: 0.65-0.95). Women in the highest quartile of fruit consumption from early to mid-pregnancy also had heavier new-borns (β = 32.3; 95% CI: 17.1-47.6), and they tended to have lower risk of LBW (OR: 0.83; 95% CI: 0.69-1.01). Results of analysing the association between changes in fruit consumption from pre- to mid-pregnancy and birth outcomes revealed that women with continuous high fruit consumption from pre- to mid-pregnancy had heavier new-borns (β = 37.6; 95% CI: 25.0-50.3), but they did not have lower risk of LBW (OR: 0.90; 95% CI: 0.77-1.06). Associations involving vegetable consumption and birth weight/risk of LBW were not observed. CONCLUSIONS: Fruit consumption before and during pregnancy was positively associated with birth weight of new-borns and negatively associated with risk of LBW.

  336. 産後うつ病の予測と予防のための血漿サイトカインレベルの検証

    兪 志前, 小野 千晶, 小原 拓, 菊地 沙耶, 小林 奈津子, 菅原 準一, 栗山 進一, 山本 雅之, 八重樫 伸生, 富田 博秋

    日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020/08

    Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会

  337. 産後うつ病の予測と予防のための血漿サイトカインレベルの検証

    兪 志前, 小野 千晶, 小原 拓, 菊地 沙耶, 小林 奈津子, 菅原 準一, 栗山 進一, 山本 雅之, 八重樫 伸生, 富田 博秋

    日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020/08

    Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会

  338. Social predictors of alcohol use and cessation during pregnancy among Japanese women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

    Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

    2020/07/15

    Publisher: Research Square

    DOI： 10.21203/rs.3.rs-40323/v1 　

    More details Close

    <title>Abstract</title> <bold>Background:</bold> Most studies on social predictors of alcohol use have been conducted at one time point during pregnancy or using postpartum retrospective reports. Furthermore, the studies were mainly conducted in Western countries. We aimed to prospectively examine social predictors of alcohol use and cessation during pregnancy in Japan.<bold>Methods:</bold> This prospective study was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Pregnant women were recruited at approximately 50 obstetric clinics and hospitals in Miyagi Prefecture in Japan. We analyzed 11592 pregnant women who completed the questionnaires administered in early pregnancy and middle pregnancy. Women were dichotomized as current drinkers or non-drinkers in both early and middle pregnancy. Age, education, income, work status, and psychological distress were used as social predictors. Multivariate logistic regression analyses were conducted to examine associations between these predictors and alcohol use in early and middle pregnancy. Associations with alcohol cessation between early pregnancy and middle pregnancy were also examined.<bold>Results:</bold> Prevalence of alcohol use in early and middle pregnancy was 20.9% and 6.4%, respectively. Higher education was associated with alcohol use in early pregnancy and alcohol cessation during pregnancy; the odds ratios (ORs) of ≥university education compared with ≤high school education were 1.47 (95% confidence interval [CI], 1.30–1.66) and 1.31 (95% CI, 1.00–1.71), respectively. Work status was associated with alcohol use in both periods and alcohol cessation during pregnancy; for alcohol cessation, the OR of working in early pregnancy only compared with not working in both periods was 1.72 (95% CI, 1.03–2.88).<bold>Conclusions:</bold> Women with higher education were more likely to consume alcohol in early pregnancy and to cease between early pregnancy and middle pregnancy. Working women were more likely to consume alcohol throughout pregnancy in Japan.

  339. Characteristics of Adverse Events Following Immunization Reporting in Children: The Japanese Adverse Drug Event Report Database. International-journal Peer-reviewed

    Aoi Noda, Takamasa Sakai, Masami Tsuchiya, Gen Oyanagi, Taku Obara, Nariyasu Mano

    Vaccines　8　(3)　2020/07/03

    DOI： 10.3390/vaccines8030357 　

    More details Close

    The present study aimed to describe the trends and characteristics of adverse events following immunization (AEFI) reporting for children in the Japanese Adverse Drug Event Report database (JADER). We used 6280 AEFI reports for children aged <19 years among 504,407 ADR reports included in the JADER from 2004 to 2017. The number of AEFI reports gradually increased among children aged <10 years and was the highest in 2011 among children aged 10-19 years. The number of suspected vaccines per AEFI report increased after 2011 among children aged <10 years. The percentage of "death" and "did not recover" as AEFI outcomes reported were 4.3% and 3.7% among children aged <10 years and 0.2% and 21.1% among children aged 10-19 years, respectively. The most frequently reported vaccine-reaction pair was Haemophilus influenzae type b conjugate vaccine and pyrexia among children aged <10 years and recombinant adsorbed bivalent human papillomavirus-like particle vaccine and a loss of consciousness among children aged 10-19 years. It is necessary to consider the Weber effects to understand the trend and characteristics of AEFI reporting because pharmacovigilance activity regarding vaccination is not sufficient in Japan.

  340. Folic acid prescribed to prenatal and postpartum women who are also prescribed antiepileptic drugs in Japan: Data from a health administrative database. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    Birth defects research　112　(16)　1224-1233　2020/07/02

    DOI： 10.1002/bdr2.1748 　

    More details Close

    BACKGROUND: The aim of this study was to evaluate the prevalence of folic acid (FA) prescription to prenatal and postpartum women who have also been prescribed antiepileptic drugs (AED) in Japan. METHODS: The data set used in this study included women covered by health insurance between 2005 and 2016. The prevalence of FA prescriptions between 180 days before pregnancy and 180 days postpartum was determined from a large administrative database, with the FA prescription classified according to dose and timing. RESULTS: For 33,941 women meeting our eligibility criteria, the mean maternal age at delivery was 32.3 years. At least one AED was prescribed to 225 of 33,941 women between 180 days before pregnancy and 180 days postpartum. FA was prescribed to 32 of 225 women (14.2%) during the same period. FA was prescribed to 8.8% of women with AED within 90 days before pregnancy and to 19.8% during the first trimester. FA was prescribed to 10.9% during the first 30 days after conception, all of whom were prescribed FA before the pregnancy. The maximum FA dose prescribed within 90 days before pregnancy was 5 mg/day for 5 of 12 women (41.7%) and >5 mg/day for 4 of 12 women (33.3%). The maximum FA dose prescribed during the first trimester was 5 mg/day for 14 of 22 women (63.6%) and >5 mg/day for 8 of 22 women (36.4%). CONCLUSIONS: The concurrent prescription of FA with AEDs in Japan was an uncommon therapeutic approach both before and during pregnancy.

  341. 【妊娠・出産と精神科臨床アップデート】授乳期の精神科薬物療法

    菊地 紗耶, 小林 奈津子, 小原 拓, 本多 奈美, 富田 博秋

    臨床精神医学　49　(7)　907-915　2020/07

    Publisher: (株)アークメディア

    ISSN： 0300-032X

  342. Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study. International-journal Peer-reviewed

    Noriyuki Iwama, Mari S Oba, Michihiro Satoh, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Satomi Sasaki, Masatoshi Saito, Yoshitaka Murakami, Shin-Ichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(6)　550-559　2020/06

    DOI： 10.1038/s41440-020-0416-2 　

    More details Close

    This study investigated the association between maternal home blood pressure (HBP) trajectory during pregnancy and infant birth weight. A total of 755 pregnant women were included in this prospective cohort study. A group-based trajectory model identified six trajectory groups for home systolic blood pressure (SBP), diastolic BP (DBP), and mean arterial pressure (MAP). Next, the association of HBP trajectory groups with infant birth weight was evaluated using a general linear model considering potential confounding factors. For home SBP and MAP, the trajectory groups with a low-steep J-curve, moderate J-curve, little high J-curve, and high J-curve were significantly associated with lower infant birth weight than the low-J-curve group. Among the trajectory groups for home DBP, the moderate-steep J-curve, little high J-curve, and high J-curve were significantly associated with lower infant birth weight than the group with low-J-curve. The effect sizes of the trajectory groups varied in infant birth weight from -0.21 standard deviations (SDs) (95% confidence interval (CI): -0.42 to -0.01 SD) to -1.13 SD (95% CI: -1.54 to -0.72 SD). In the analyses of infant birth weight in grams, effect sizes that were significantly associated with infant birth weight varied from -84 g (95% CI: -167 to -1 g) to -567 g (95% CI: -732 to -402 g). Trajectory groups with a moderate-reverse J-curve for home SBP, DBP, and MAP were not significantly associated with infant birth weight. Maternal HBP trajectory during pregnancy was an indicator of infant birth weight. Further studies evaluating the associations between HBP during pregnancy and other perinatal outcomes are needed.

  343. Characteristics of pediatric adverse drug reaction reports in the Japanese Adverse Drug Event Report Database. International-journal Peer-reviewed

    Aoi Noda, Takamasa Sakai, Taku Obara, Makoto Miyazaki, Masami Tsuchiya, Gen Oyanagi, Yuriko Murai, Nariyasu Mano

    BMC pharmacology & toxicology　21　(1)　36-36　2020/05/24

    DOI： 10.1186/s40360-020-00412-7 　

    More details Close

    BACKGROUND: There are no reports on investigations of the characteristics of adverse drug reaction (ADR) reports for pediatric patients in the Japanese Adverse Drug Event Report database (JADER) and the utility of database for drug safety surveillance in these patients. METHOD: We aimed to evaluate ADR reports for pediatric patients in the JADER. We used spontaneous ADR reports included in the JADER since April 1, 2004, to December 31, 2017, which was downloaded in April 2018. In a total of 504,407 ADR reports, the number of spontaneous reports was 386,400 (76.6%), in which 37,534 (7.4%) were unknown age reports. After extraction of 27,800 ADR reports for children aged < 10 and 10-19 years, we excepted for ADR reports associated with a vaccine (n = 6355) and no-suspected drug reports (n = 86). A total of 21,359 (4.2%) reports were finally included in this analysis. RESULTS: More than half of the ADR reports were for children aged < 10 years. Approximately 30% of ADR reports had multiple suspected drugs, which did not differ by age. The percentages of fatal outcomes of ADRs among patients aged < 10 and 10-19 years were 4.7 and 3.9%, respectively. The most frequently reported drug, reaction, and drug-reaction pair were oseltamivir, abnormal behavior, and oseltamivir and abnormal behavior, respectively. CONCLUSION: We clarified the characteristics of ADR reports for Japanese children by using the JADER. ADR report databases, especially those for pediatric patients, are valuable pharmacovigilance tools in Japan and other countries. Therefore, a proper understanding of the characteristics of the ADR reports in the JADER is important. Additionally, potential signals for ADRs in pediatric patients should be monitored continuously and carefully.

  344. Quantitative analysis of paracetamol, metacetamol, and orthocetamol in equine urine from racehorses in Japan using liquid chromatography-electrospray ionisation-tandem mass spectrometry. International-journal Peer-reviewed

    Hideaki Ishii, Taku Obara, Kanichi Kusano, Isao Kijima-Suda

    Drug testing and analysis　2020/05/20

    DOI： 10.1002/dta.2860 　

    More details Close

    Paracetamol is commonly used as an over-the-counter analgesic and antipyretic medication for humans, but not sold as a legitimate therapeutic medication for horses in Japan. However, paracetamol is commonly found in horses together with its two isomers, metacetamol and orthocetamol. We previously reported that paracetamol and orthocetamol were both present in selected feed consumed by Japanese racehorses. For the purpose of doping control of paracetamol in local Japanese horses, we proposed establishing residue limits (Japanese residue limits, JRLs) to minimise the risk of reporting paracetamol from environmental contributions and differentiate its presence from active administration. Recently, we proposed a preliminary JRL for paracetamol in equine plasma based on a population study in more than 300 Japanese racehorses. In this paper, we will present our studies on the urinary concentrations of paracetamol, metacetamol, and orthocetamol in postrace samples collected from 403 Japanese racehorses over a one-year period, detected using liquid chromatography-electrospray ionisation-tandem mass spectrometry. Our results revealed that the hydrolysed urinary concentrations of paracetamol, metacetamol, and orthocetamol ranged from 15.7 to 2,360 ng/mL (median 363 ng/mL), 8.07 to 382 ng/mL (84.5 ng/mL), and 919 to 74,418 ng/mL (13,475 ng/mL), respectively. Based on our statistical model, the preliminary JRL of hydrolysed paracetamol in equine urine was determined to be 7,400 ng/mL at a risk factor of 1 in 10,000. Further investigations will be required to demonstrate the applicability and validity of our preliminary plasma and urine JRLs to local Japanese racehorses.

  345. Changes in community pharmacists' knowledge, attitudes, and practice regarding the management of hypertension before and after educational interventions. International-journal Peer-reviewed

    Aoi Noda, Taku Obara, Kazuki Takada, Yukinaga Kishikawa, Shinya Abe, Shoko Yoshimachi, Nariyasu Mano, Yutaka Imai, Teruaki Goto

    Clinical and experimental hypertension (New York, N.Y. : 1993)　42　(4)　322-327　2020/05/18

    DOI： 10.1080/10641963.2019.1652634 　

    More details Close

    Objective: To clarify changes in community pharmacists' knowledge, attitudes, and practice regarding the management of hypertension before and after attending educational interventions based on their self-report on a questionnaire survey.Method: We conducted questionnaire surveys regarding the management of hypertension with a sample of community pharmacists before and after educational interventions.Results: The proportions of pharmacists who knew the 2014 Japanese Society of Hypertension Guidelines, guidelines for home blood pressure measurement, reference values for hypertension based on clinic-measured blood pressure, and reference values for hypertension based on home-measured blood pressure after the educational interventions (59.3%, 41.4%, 75.1%, and 70.8% respectively) were significantly higher relative to those recorded before interventions (31.6%, 13.7%, 47.7%, and 25.4% respectively).Conclusions: These findings suggest that in-house training might increase the knowledge of community pharmacists regarding hypertension management.

  346. Examining the trimester-specific effects of low gestational weight gain on birthweight: the BOSHI study. International-journal Peer-reviewed

    Mari S Oba, Yoshitaka Murakami, Michihiro Satoh, Takahisa Murakami, Mami Ishikuro, Taku Obara, Kazuhiko Hoshi, Yutaka Imai, Takayoshi Ohkubo, Hiroto Metoki

    Journal of developmental origins of health and disease　12　(2)　1-6　2020/04/22

    DOI： 10.1017/S2040174420000240 　

    More details Close

    Low gestational weight gain (GWG) is a known risk factor of low birthweight. Although studies have previously examined the associations between GWG and birthweight, the period-specific effects of low GWG in each trimester remain unclear. This study aimed to quantify the trimester-specific direct effects of low GWG in Japanese women on birthweight. Using perinatal data from a cohort study, we analyzed pregnant women delivered at an obstetrics/gynecology hospital between October 2006 and May 2010. We focused on women with a pre-pregnancy body mass index (BMI) below 25 kg/m2. The exposure was low GWG. The gestation period was subdivided into trimesters, and the direct effects of low trimester-specific GWG on birthweight were estimated using marginal structural models. These models were guided by a direct acyclic graph that incorporated potential confounders, including pre-pregnancy BMI, age, smoking during pregnancy, height, and parity. We analyzed 563 women and their families. The mean cumulative GWG by the end of the first, second, and third trimesters was 0.9, 6.2, and 10.7 kg, respectively. Approximately 14.0% of the women gained total weight below the range recommended by Japanese Ministry of Health, Labour and Welfare. The direct effects of low GWG on birthweight were 65.9 g (95% confidence interval: 11.4, 120.5), -195.4 g (-263.4, -127.4), and -188.8 g (-292.0, -85.5) for the first, second, and third trimesters, respectively. Insufficient weight gain in the second and third trimesters had a negative impact on birthweight after adjusting for pre-pregnancy BMI and other covariates.

  347. Publisher Correction: Inadequate Folic Acid Intake Among Women Taking Antiepileptic Drugs During Pregnancy in Japan: A Cross-Sectional Study. International-journal Peer-reviewed

    Yasuko Ikeda-Sakai, Yoshiyuki Saito, Taku Obara, Mikako Goto, Tami Sengoku, Yoshimitsu Takahashi, Hiromi Hamada, Takeo Nakayama, Atsuko Murashima

    Scientific reports　10　(1)　6414-6414　2020/04/14

    DOI： 10.1038/s41598-020-63105-5 　

    More details Close

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

  348. 東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

    寳澤 篤, 土屋 菜歩, 平田 匠, 小暮 真奈, 成田 暁, 中村 智洋, 中谷 直樹, 小原 拓, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌　(52)　20-20　2020/04

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  349. 非喫煙妊婦における教育歴と受動喫煙の関連 東北メディカル・メガバンク計画三世代コホート調査

    村上 慶子, 小原 拓, 石黒 真美, 上野 史彦, 野田 あおい, 大柳 元, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    宮城県公衆衛生学会会誌　(52)　22-22　2020/04

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  350. 妊娠初期の家庭血圧レベルと短期及び長期の母児予後との関連

    目時 弘仁, 佐藤 倫広, 村上 任尚, 岩間 憲之, 佐々木 里美, 高畠 恭介, 石黒 真美, 小原 拓, 菊谷 昌浩, 大久保 孝義, 八重樫 伸生, 星 和彦, 今井 潤

    宮城県公衆衛生学会会誌　(52)　13-13　2020/04

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  351. 東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

    寳澤 篤, 土屋 菜歩, 平田 匠, 小暮 真奈, 成田 暁, 中村 智洋, 中谷 直樹, 小原 拓, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌　(52)　20-20　2020/04

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  352. 妊娠初期の家庭血圧レベルと短期及び長期の母児予後との関連

    目時 弘仁, 佐藤 倫広, 村上 任尚, 岩間 憲之, 佐々木 里美, 高畠 恭介, 石黒 真美, 小原 拓, 菊谷 昌浩, 大久保 孝義, 八重樫 伸生, 星 和彦, 今井 潤

    宮城県公衆衛生学会会誌　(52)　13-13　2020/04

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  353. The quality assessment of the Japanese Adverse Drug Event Report database using vigiGrade. International-journal Peer-reviewed

    Masami Tsuchiya, Taku Obara, Makoto Miyazaki, Aoi Noda, Chizuko Takamura, Nariyasu Mano

    International journal of clinical pharmacy　42　(2)　728-736　2020/04

    DOI： 10.1007/s11096-020-00969-7 　

    More details Close

    Background The quality of adverse drug reaction reports can have a strong influence on the causality assessment or the detection of safety signals. Various methods have been used to evaluate the quality of adverse drug reaction reports. Objective We used the vigiGrade completeness score to evaluate the quality of the Japanese adverse drug event report database (JADER). Methods Among all reports in the JADER (cases received by regulatory authorities from April 2004 to November 2018), 427,797 cases that did not meet the exclusion criteria were analyzed using vigiGrade. An report was considered a 'well-documented' report if the completeness score > 0.8. For each dimension, the proportion of incomplete information was calculated. Main outcome measure Proportion of 'well-documented' reports. Results A total of 211,774 (49.5%) cases were classified as 'well-documented' reports. When classified by sender, 6240 out of 8257 cases (75.6%) from medical institutions were 'well-documented', while 205,534 out of 419,540 cases (49.0%) from pharmaceutical companies were categorized as such. 'Time-to-onset' could not be calculated in 173,027 (41.2%) cases from the pharmaceutical companies and in 1228 (14.9%) cases from medical institutions. Conclusion In the JADER, the proportion of 'well-documented' adverse drug reaction reports from medical institutions was higher than that from pharmaceutical companies, and reports from medical institutions could help to clarify generated safety signals. We also found that more than 40% of the reports from pharmaceutical companies did not include information that is considered essential for the evaluation of any causal relationship between suspected drugs and adverse drug reactions, which could pose challenges to the detection of safety signals.

  354. Investigation of plasma concentrations of paracetamol, metacetamol, and orthocetamol in Japanese racehorses using liquid chromatography-electrospray ionisation-tandem mass spectrometry. International-journal Peer-reviewed

    Hideaki Ishii, Taku Obara, Isao Kijima-Suda

    Drug testing and analysis　2020/03/18

    DOI： 10.1002/dta.2792 　

    More details Close

    Paracetamol is used widely as an over-the-counter analgesic and antipyretic medication for humans, but not for Japanese racehorses. Paracetamol can be an environmental substance, and is found together with its two isomers, metacetamol and orthocetamol, in equine urine. However, the sources and routes of paracetamol exposure remain unclear. To control the misuse of paracetamol, it is appropriate to establish residue limits for paracetamol to differentiate the administration of paracetamol from its environmental levels. In this study, we developed and validated a quantitative method for paracetamol, metacetamol, and orthocetamol in equine plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry and applied it to postrace samples from 320 Japanese racehorses for approximately 1 year. In addition, we conducted feed analysis and related pharmacokinetics simulations to evaluate the contributions from exposure via feed. The hydrolyzed plasma concentrations of paracetamol, metacetamol, and orthocetamol ranged from 0.787 to 39.8 ng/mL (median 5.87 ng/mL), 0 to 2.13 ng/mL (0.347 ng/mL), and 1.98 to 82.8 ng/mL (16.6 ng/mL), respectively. Such low concentrations of paracetamol were deemed irrelevant to therapeutic effect. Based on statistical analysis, the preliminary Japanese residue limits of unhydrolyzed and hydrolyzed paracetamol were determined to be 70.5 ng/mL and 112 ng/mL, respectively, in plasma, at a risk factor of 1 in 10,000. Furthermore, we detected paracetamol and orthocetamol in feed samples. A pharmacokinetics simulation showed that the presence of orthocetamol is most probably related to daily feed rations. As for paracetamol, feed can be one of the sources and other possible sources require further investigation.

  355. Evaluating folic acid supplementation among Japanese pregnant women with dietary intake of folic acid lower than 480 µg per day: results from TMM BirThree Cohort Study. International-journal Peer-reviewed

    Daisuke Kikuchi, Taku Obara, Takuma Usuzaki, Yudai Yonezawa, Takahiro Yamashita, Gen Oyanagi, Aoi Noda, Fumihiko Ueno, Keiko Murakami, Hiroko Matsubara, Mami Ishikuro, Hirohito Metoki, Masahiro Kikuya, Shinichi Kuriyama

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　35　(5)　1-6　2020/03/13

    DOI： 10.1080/14767058.2020.1739020 　

    More details Close

    Objective: In Japan, supplementation with 400 µg of folic acid per day is recommended for women who are planning to get pregnant to decrease the risk of their babies getting neural tube defects (NTD). However, the proportion of women who have taken folic acid supplements before conception is low among Japanese pregnant women. In addition, the dietary intake of folic acid has not yet reached the government recommended dietary intake levels (480 µg per day). This study aimed to clarify the prevalence and determinants of adequate folic acid supplements among Japanese pregnant women with dietary folic acid intake lower than 480 µg per day.Methods: This cross-sectional study was a part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. We collected information on folic acid supplements before conception, sociological/lifestyle characteristics, and food consumption. The primary outcome was the use of folic acid supplements (adequate or inadequate, based on the timing of initiation of folic acid supplements). Multiple logistic regression analysis was used to examine the association between sociological/lifestyle characteristics and the adequate intake of folic acid supplements.Results: Among the 11,562 pregnant women who took lower than 480 µg per day of folic acid from food, the prevalence of adequate users was 18.0%. Pregnant women who reported adequate use of folic acid supplements were more likely to be older and educated; and reported higher household income, and history of fertility treatment. Conversely, they were less likely to be ever or current smokers and multipara.Conclusion: This study found that the prevalence of folic acid supplements use for the prevention of NTD among Japanese pregnant women was still low.

  356. Bootstrap法およびPermutation法の応用による三世代家族の身長、体重、BMIの世代間関連の評価 三世代コホート調査

    臼崎 琢磨, 石黒 真美, 村上 慶子, 野田 あおい, 上野 史彦, 目時 弘仁, 菊谷 昌浩, 小原 拓, 栗山 進一

    日本衛生学雑誌　75　(Suppl.)　S158-S158　2020/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  357. 家系情報付き出生三世代コホートの構築に基づく成果の還元と試料・情報の分譲

    小原 拓, 村上 慶子, 石黒 真美, 上野 史彦, 野田 あおい, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    日本衛生学雑誌　75　(Suppl.)　S158-S158　2020/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  358. 薬局勤務薬剤師における副作用等報告制度の認識と実践

    原 梓, 山口 浩, 小原 拓, 神藤 愛実, 沢 諒, 阿部 真也, 吉町 昌子, 後藤 輝明, 宮崎 生子, 眞野 成康

    日本薬学会年会要旨集　140年会　27P-pm032　2020/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  359. Antidepressant prescriptions for prenatal and postpartum women in Japan: A health administrative database study. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Keiko Miyakoda, Hidekazu Nishigori, Hiroaki Tomita, Manabu Akazawa, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    Journal of affective disorders　264　295-303　2020/03/01

    DOI： 10.1016/j.jad.2020.01.016 　

    More details Close

    BACKGROUND: The prevalence and pattern of perinatal antidepressant prescriptions in Japan are unknown. METHODS: The prevalence of antidepressant prescriptions between 180 days before pregnancy onset and 180 days postpartum was evaluated using a large administrative database. The dates of pregnancy onset and delivery were estimated using developed algorithms. RESULTS: Of 33,941 women, at least one antidepressant was prescribed to 451 (133/10,000 deliveries) between 180 days before pregnancy and 180 days postpartum and to 241 (71/10,000 deliveries) during pregnancy. The prevalence of antidepressant prescriptions decreased during the first and second trimesters and increased in the postpartum period. Of 339 women with antidepressant prescriptions before pregnancy, 151 (44.5%) discontinued it during pregnancy. Selective serotonin-reuptake inhibitors were the most frequently prescribed class of antidepressants in the time period studied (356 women, 105/10,000 deliveries), followed by tricyclic/non-tricyclic antidepressants (101 women, 30/10,000 deliveries). Of the 57 women who had at least one record of paroxetine prescription in the first trimester, 13 (22.8%) were prescribed >25 mg/day. Fifty-seven women (17/10,000 deliveries) were concurrently prescribed two or more classes of antidepressants between 180 days before pregnancy and 180 days postpartum. LIMITATIONS: It may not always have been the case that the prescribed antidepressants were used. Women whose pregnancy ended in an abortion or stillbirth were not included. CONCLUSIONS: Various antidepressants were prescribed to prenatal and postpartum women in Japan. Approximately half of pregnant women discontinued treatment with antidepressants after becoming pregnant. Women of childbearing age should select an appropriate antidepressant considering the risk/benefit profile.

  360. Quality evaluation of the Japanese Adverse Drug Event Report database (JADER). International-journal Peer-reviewed

    Masami Tsuchiya, Taku Obara, Takamasa Sakai, Kaori Nomura, Chizuko Takamura, Nariyasu Mano

    Pharmacoepidemiology and drug safety　29　(2)　173-181　2020/02

    DOI： 10.1002/pds.4944 　

    ISSN： 1053-8569

    More details Close

    INTRODUCTION: The spontaneous adverse drug reaction (ADR) reporting system plays an important role in pharmacovigilance by providing information from clinical settings in the postmarketing environment. The Japanese Adverse Drug Event Report (JADER) database contains a portion of Japanese ADR reports, and no previous study has described the quality or characteristics of ADR reports in the JADER. OBJECTIVE: The aim of this study was to identify the characteristics of the JADER database and to evaluate the quality of ADR reports contained in the JADER using the documentation-grading scheme developed by the World Health Organization. METHODS: Of 478 508 ADR reports in the JADER, the analysis set consisted of 395 091 reports meeting inclusion criteria. An analysis was carried out to evaluate the quality of the reports according to the type of report, the type of sender, and the qualification of the reporter. Annual changes in the number of reports from medical institutions submitted by pharmacists were compared with changes in the number submitted by physicians. RESULTS: The distribution of documentation grade differed according to the type of report, the type of sender, and the qualification of the reporter. Regarding "medical institution reports", the quality of reports was similar among qualification types, while the quality of reports submitted by physicians was higher for "company reports" and "study reports" (P < .0001, respectively). CONCLUSION: Our study showed that the quality of the ADR reports in the JADER differed among the type of report, the sender of the report, and the qualification of the reporter.

  361. Update on the prevalence and determinants of folic acid use in Japan evaluated with 91,538 pregnant women: the Japan Environment and Children's Study. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(3)　427-436　2020/02

    DOI： 10.1080/14767058.2018.1494712 　

    ISSN： 1476-7058

    More details Close

    Objective: To provide the latest and most promising evidence on the prevalence and determinants for folic acid supplementation in pregnant women in Japan, including differences in prevalence between interview years and determinants across regions.Materials and methods: The study participants were enrolled from 15 regional centers across Japan between January 2011 and March 2014. Information on the use of folic acid supplementation before and during pregnancy and the characteristics of the participants were collected using questionnaires, medical chart reviews, and interviews by research coordinators.Results: Data for 91,538 women who provided sufficient data on folic acid supplementation were analyzed. The prevalence of adequate users was 8.0%, which, although low, tended to improve over the 4-year recruitment period. Various kinds of sociodemographic factors, lifestyle habits, and obstetrical and medication use history were significant and independent determinants for folic acid use. Associations between adequate preconception folic acid use and its major determinants tended to be similar across regions.Conclusions: Although the prevalence of adequate folic acid use was low, it increased from 2011 to 2014. Reproductive-aged women who have determinants for inadequate folic acid use should be informed about the need for preconception folic acid supplementation to help prevent neural tube defects.

  362. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International-journal Peer-reviewed

    Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    International journal of epidemiology　49　(1)　18-19　2020/02/01

    DOI： 10.1093/ije/dyz169 　

    ISSN： 0300-5771

  363. Study profile of The Tohoku Medical Megabank Community-Based Cohort Study. Peer-reviewed

    Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

    Journal of epidemiology　31　(1)　65-76　2020/01/11

    DOI： 10.2188/jea.JE20190271 　

    More details Close

    BackgroundWe established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environmental interactions on the incidence of major diseases such as cancer and cardiovascular diseases.MethodsWe asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria was aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), for example, carotid echography, calcaneal ultrasound bone mineral density, and so on. All participants agreed to measure genome information and to distribute their information widely.ResultsAs a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants with Type 1 survey were more likely to have psychological distress than those of Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents regardless of sex.ConclusionThis cohort comprised large sample size and it contains information on disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.

  364. Drug Prescriptions for Children With ADHD in Japan: A Study Based on Health Insurance Claims Data Between 2005 and 2015. International-journal Peer-reviewed

    Makiko Yoshida, Taku Obara, Saya Kikuchi, Michihiro Satoh, Yoshihiko Morikawa, Nobuhiro Ooba, Hiroaki Yamaguchi, Nariyasu Mano

    Journal of attention disorders　24　(2)　175-191　2020/01

    DOI： 10.1177/1087054719843179 　

    ISSN： 1087-0547

    More details Close

    Objective: The aim of this study is to investigate the trend of prescription drugs for children with ADHD in Japan. Method: Using health insurance claims data of 3,672,951 people between January 2005 and December 2015, we investigated the trend of prescription drugs for 7,856 children with ADHD. Results: After approval in 2007, the proportion of prescriptions for methylphenidate-osmotic-controlled release oral delivery system tablets was 31.4% in 2009 (adjusted odds ratio [AOR] = 2.72; 95% confidence interval [CI] = [2.12, 3.51]) and reached a plateau approximately after 2009 (AOR = 0.96; 95% CI = [0.94, 0.98]). The proportion of prescriptions for atomoxetine increased from 6.1% in 2008 to 21.8% in 2014 (AOR = 1.12; 95% CI = [1.13, 1.18]). The proportion of prescriptions for aripiprazole and ramelteon increased (all trend p < .001). Conclusion: Prescriptions of drugs for children with ADHD have changed. We need to monitor the safety of ADHD medications among children with ADHD.

  365. The present situation of home blood pressure measurement among outpatients in Japan. International-journal Peer-reviewed

    Aoi Noda, Taku Obara, Shinya Abe, Shoko Yoshimachi, Michihiro Satoh, Mami Ishikuro, Azusa Hara, Hirohito Metoki, Nariyasu Mano, Takayoshi Ohkubo, Teruaki Goto, Yutaka Imai

    Clinical and experimental hypertension (New York, N.Y. : 1993)　42　(1)　67-74　2020

    DOI： 10.1080/10641963.2019.1571601 　

    More details Close

    Objective: To clarify the present situation of home blood pressure (HBP) measurement among Japanese patients.Methods: A nationwide questionnaire survey regarding HBP measurement was conducted on patients aged 20 years or older who had visited 20 community pharmacies to have their prescriptions filled.Results: In total, 76.7% of 1,103 hypertensives and 40.9% of 1,106 normotensives had their own devices for HBP measurement. Compared with normotensives, a higher proportion of hypertensives recognized the guideline-based reference values for HBP and clinic BP. Compared with hypertensives who did not have a physician's recommendation, those who did more often had their own devices, recognized the guideline-based reference values for HBP, and measured HBP every day (70.4%, 1.5%, and 31.6% vs. 91.1%, 6.9%, and 65.4%, respectively). Among 793 hypertensives who measured HBP, a higher proportion of those with a physician's recommendation measured HBP according to optimal guideline-based procedures compared with those without. Among 560 hypertensives who recorded HBP readings, a higher proportion of those with a physician's recommendation (74.6%) showed all HBP readings to their physicians compared with those without (35.3%).Conclusions: Our findings suggest that physicians should recommend measuring HBP in accordance with the Japanese Society of Hypertension guidelines more aggressively, and provide more detailed explanations to patients regarding how to measure HBP.

  366. Effectiveness of seasonal inactivated influenza vaccination in Japanese schoolchildren: an epidemiologic study at the community level. International-journal Peer-reviewed

    Yasutaka Kuniyoshi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Masato Nagai, Keiko Murakami, Aoi Noda, Masahiro Kikuya, Shigeo Kure, Shinichi Kuriyama

    Human vaccines & immunotherapeutics　16　(2)　295-300　2020

    DOI： 10.1080/21645515.2019.1655833 　

    ISSN： 2164-5515

    More details Close

    Influenza vaccination is the most effective method for preventing influenza virus infection. The incidence of influenza is higher in schoolchildren than other age groups. This study evaluated the effectiveness of seasonal inactivated influenza vaccination (IIV) in a community population of schoolchildren during two seasons. This study was a cross-sectional survey of public schoolchildren based on data collected in the 2012/2013 and 2014/2015 seasons. The questionnaire was distributed to all public schoolchildren of target grade in a survey area, and 7945 respondents were included in the analysis. The vaccination status and influenza onset were defined based on the self-reported questionnaire by parents or guardians. Generalized linear mixed models were used to adjust clustering within schools and individual covariates and calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between vaccination status and influenza onset. The influenza incidence was higher in the 2015 than the 2013 survey (25% versus 17%), although the vaccination rates were comparable between the two seasons. Receiving one- or two-dose vaccination was more protective against influenza than non-vaccination in both the 2013 (OR, 0.77; 95%CI, 0.65-0.92) and 2015 (OR, 0.88; 95%CI, 0.75-1.02) surveys. Full vaccination was also more protective in both the 2013 (OR, 0.75; 95%CI, 0.62-0.89) and 2015 (OR, 0.86; 95%CI, 0.74-1.00) surveys. Seasonal IIV was protective against influenza for Japanese schoolchildren in a community-based real-world setting. The difference in clinical effectiveness of IIV between the two seasons was likely due to the antigenic mismatch between the circulating and vaccine strains.

  367. 大規模健診時血圧データに基づく加齢に伴う血圧推移に関する縦断解析 Peer-reviewed

    佐藤 倫広, 村上 任尚, 小原 拓, 辰巳 友佳子, 高畠 恭介, 原 梓, 浅山 敬, 今井 潤, 菊谷 昌浩, 大久保 孝義, 目時 弘仁

    日本循環器病予防学会誌　54　(3)　163-170　2019/12

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  368. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. International-journal Peer-reviewed

    Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

    Disaster medicine and public health preparedness　13　(5-6)　905-911　2019/12

    DOI： 10.1017/dmp.2019.8 　

    ISSN： 1935-7893

    More details Close

    OBJECTIVE: We aimed to investigate the association between types of housing and allergic symptoms at 3-4 years following the Great East Japan Earthquake. METHODS: Our study was based on the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey of public school children in Miyagi Prefecture, Japan. Of the 46 648 invited schoolchildren in the 2nd to 8th grades, 9884 were included. Presence of eczema, wheezing, and mental health symptoms was defined with questionnaires. To calculate odds ratios (ORs) and 95% CIs for the associations between types of housing and eczema or respiratory symptoms, we fitted generalized linear mixed models, included a random effect for municipality of residence, and adjusted for sex, school grade, survey year, and mental health symptoms. RESULTS: Prefabricated temporary housing was significantly associated with eczema symptoms (OR, 1.46; 95% CI, 1.06-2.02). Even after adjusting for the presence of mental health symptoms, our analysis produced similar results (OR, 1.42; 95% CI, 1.03-1.96). Conversely, it was not significantly associated with respiratory symptoms (OR, 0.97; 95% CI, 0.61-1.54). CONCLUSIONS: Children living in prefabricated temporary housing had a higher prevalence of eczema symptoms; however, prevalence of respiratory symptoms was not significantly higher.

  369. Maternal dietary patterns during early pregnancy and birth weight in Japan

    Taku Obara, Hiroyuki Suganuma, Mami Ishikuro, Takuma Usuzaki, Takahiro Yamashita, Fumihiko Ueno, Yudai Yonezawa, Shinichi Kuriyama, Aoi Noda, Keiko Murakami

    European Journal of Public Health　29　2019/11/01

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/eurpub/ckz187.128 　

    ISSN： 1101-1262

    eISSN： 1464-360X

    More details Close

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>The average birth weight in Japan has decreased by 200 g in the last 40 years. Only three studies were reported for the association between maternal dietary patterns and birth weight in East Asia, whose results were inconsistent. We examined what maternal dietary patterns were associated with the birth weight in Japan.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Totally 22,493 pregnant women were recruited between July 2013 and September 2016 into the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. We included 17,287 women who had a full-term single healthy baby into the analysis. Consumption of food and beverage items was evaluated based on food frequency questionnaire at the first-trimester. Dietary patterns were analyzed using a machine learning method of k-means clustering algorithm. Birth weight was obtained from the medical record. The association between dietary patterns and birth weight was analyzed using multiple liner regression model adjusted for potential confounders with multiple imputation method for missing values.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Dietary patterns were classified into seven groups by cluster analysis: “high in rice (reference) (n = 8046)”, “middle in vegetables, beans, mushrooms, seaweeds and miso-soup (n = 4842)”, “high in fruits (n = 1176)”, “high in bread, dairy and alcohol (n = 1091)”, “high in meat and fish (n = 1049)”, “high in coffee, black tea, soft drinks and confections (high in coffee) (n = 585)”, and “high in vegetables, beans, mushrooms, seaweeds and miso-soup (n = 498)” groups. In multiple liner regression models, birth weight was 22.6 g (95%CI: 0.1 to 45.2 g) heavier in “high in fruits” group than in reference group and 39.4 g (95%CI: 8.6 to 70.3 g) lighter in “high in coffee” group than in reference group. The other groups were not statistically significant.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>High consumption of fruits and high consumption of coffee, black tea, soft drinks and confections during early pregnancy were associated with increased and decreased birth weight, respectively.</jats:p> </jats:sec> <jats:sec> <jats:title>Key messages</jats:title> <jats:p>We found maternal dietary patterns during early pregnancy using a machine learning method of k-means clustering algorithm. We found maternal dietary patterns which associated with the birth weight in Japan.</jats:p> </jats:sec>

  370. Interannual Changes in the Prevalence of Intimate Partner Violence Against Pregnant Women in Miyagi Prefecture After the Great East Japan Earthquake: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Kaou Tanoue, Hidekazu Nishigori, Zen Watanabe, Kosuke Tanaka, Kasumi Sakurai, Satoshi Mizuno, Mami Ishikuro, Taku Obara, Masahito Tachibana, Tetsuro Hoshiai, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Journal of interpersonal violence　36　(21-22)　886260519881517-886260519881517　2019/10/16

    DOI： 10.1177/0886260519881517 　

    ISSN： 0886-2605

    More details Close

    This study aimed to clarify the interannual changes in intimate partner violence against pregnant women after the March 11, 2011 Great East Japan Earthquake in target areas of Miyagi Prefecture that were damaged by the earthquake and tsunami. Because of this disaster, in Miyagi Prefecture, approximately 12,000 people died or went missing, and approximately 238,000 buildings were destroyed. According to the U.S. Geological Survey, the Great East Japan Earthquake is the fourth largest earthquake in the world and the largest in Japan since 1900. The present study was part of the Japan Environment and Children's Study. Data from June 2011 to May 2014 of 79,222 pregnant women were analyzed, calculating the prevalence of physical and mental intimate partner violence in the inland, north coastal, and south coastal areas of Miyagi. These prevalence rates were compared with nationwide rates of intimate partner violence in 2011 using univariate and logistic regression analyses. After the disaster, the incidence of mental intimate partner violence increased in the south coastal area and then improved later (19.4%, 13.1%, and 13.3% for south coastal area, and 13.8%, 13.8%, and 13.1% for nationwide in 2011, 2012, and 2013, respectively). However, in the north coastal area, the incidence of physical intimate partner violence increased after the disaster and then improved later (2.7%, 1.5%, and 1.3% for north coastal area, and 1.4%, 1.3%, and 1.1% for nationwide in 2011, 2012, and 2013, respectively). In the inland area, however, the prevalence of both mental and physical intimate partner violence was consistently higher than nationwide rates after the disaster.

  371. TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

    寳澤 篤, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 布施 昇男, 山本 雅之

    日本公衆衛生学会総会抄録集　78回　212-212　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  372. 6.3万人データ分譲に向けて 東北メディカル・メガバンク計画地域住民コホート調査

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 村上 慶子, 小原 拓, 中谷 直樹, 丹野 高三, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　212-212　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  373. 高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討 東北メディカル・メガバンク計画コホート調査の成果から

    小暮 真奈, 平田 匠, 土屋 菜歩, 中村 智洋, 宮川 健, 小清水 宏, 小原 拓, 目時 弘仁, 宇留野 晃, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　287-287　2019/10

    Publisher: (NPO)日本高血圧学会

  374. 非喫煙者における受動喫煙の有無と家庭高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 佐藤 倫広, 土屋 菜歩, 中村 智洋, 宇留野 晃, 小原 拓, 目時 弘仁, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　288-288　2019/10

    Publisher: (NPO)日本高血圧学会

  375. 本態性高血圧患者における治療前および降圧治療中の家庭血圧指標の予後予測能 HOMED-BP研究 Peer-reviewed

    渡部 大介, 浅山 敬, 花澤 智大, 保坂 実樹, 佐藤 倫広, 安井 大策, 小原 拓, 井上 隆輔, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　42回　223-223　2019/10

    Publisher: (NPO)日本高血圧学会

  376. Inadequate Folic Acid Intake Among Women Taking Antiepileptic Drugs During Pregnancy in Japan: A Cross-Sectional Study. International-journal Peer-reviewed

    Yasuko Ikeda-Sakai, Yoshiyuki Saito, Taku Obara, Mikako Goto, Tami Sengoku, Yoshimitsu Takahashi, Hiromi Hamada, Takeo Nakayama, Atsuko Murashima

    Scientific reports　9　(1)　13497-13497　2019/09/18

    DOI： 10.1038/s41598-019-49782-x 　

    More details Close

    This study aimed to assess characteristics of pregnant women taking antiepileptic drugs with inadequate folic acid intake. This cross-sectional study examined pregnant women taking antiepileptic drugs who were registered in the Japanese Drug Information Institute in Pregnancy (JDIIP) database between October 2005 and December 2016. Participants were classified into two groups according to when they started folic acid supplementation (before pregnancy: 'adequate', after pregnancy or never: 'inadequate'). Logistic regression analysis was performed to investigate factors associated with inadequate folic acid intake. Of 12,794 registrants, 468 pregnant women were taking antiepileptics during the first trimester. Of these, we analysed data from 456 women who had no missing data. As a result, inadequate folic acid intake was noted among 83.3% of them, suggesting that the current level of folic acid intake is insufficient overall. Younger age, smoking, alcohol drinking, multiparity, unplanned pregnancy, and being prescribed AEDs by paediatric or psychiatric departments were independent factors associated with inadequate folic acid intake. As planned pregnancy was the strongest factor, healthcare professionals should ensure that childbearing women taking antiepileptics are informed of the importance of planned pregnancy. In addition, healthcare professionals must gain a better understanding of folic acid intake, as the prevalence of adequate intake differed according to which departments prescribed antiepileptic drugs.

  377. Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study. International-journal Peer-reviewed

    Michihiro Satoh, Hirohito Metoki, Kei Asayama, Takahisa Murakami, Ryusuke Inoue, Megumi Tsubota-Utsugi, Ayako Matsuda, Takuo Hirose, Azusa Hara, Taku Obara, Masahiro Kikuya, Kyoko Nomura, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    Journal of the American Heart Association　8　(15)　e012121　2019/08/06

    DOI： 10.1161/JAHA.119.012121 　

    More details Close

    Background Home blood pressure is a more accurate prognosticator than office blood pressure and allows the observation of day-to-day blood pressure variability. Information on blood pressure change during the life course links the prediction of blood pressure elevation with age. We prospectively assessed age-related trends in home blood pressure, home pulse rate, and their day-to-day variability evaluated as a coefficient of variation. Methods and Results We examined 1665 participants (men, 36.0%; mean age, 56.2 years) from the general population of Ohasama, Japan. A repeated-measures mixed linear model was used to estimate the age-related trends. In a mean of 15.9 years, we observed 5438 points of measurements including those at baseline. The home systolic blood pressure linearly increased with age and was higher in men than in women aged <70 years. There was an inverse-U-shaped age-related trend in home diastolic blood pressure. The day-to-day home systolic blood pressure linearly increased with age in individuals aged >40 years. However, an U-shaped age-related trend in day-to-day diastolic blood pressure variability with the nadir point at 65 to 69 years of age was observed. No significant sex differences in the day-to-day blood pressure variability were observed (P≥0.22). The average and day-to-day variability of home pulse rate decreased with age but were lower and higher, respectively, in men than in women. Conclusions The current descriptive data are needed to predict future home blood pressure and pulse rate. The data also provide information on the mechanism of day-to-day blood pressure and pulse rate variability.

  378. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. International-journal Peer-reviewed

    Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Fuji Nagami, Naoko Minegishi, Soichi Ogishima, Takako Takai-Igarashi, Inaho Danjoh, Taku Obara, Mami Ishikuro, Tomoko Kobayashi, Yayoi Aizawa, Rino Ishihara, Masayuki Yamamoto, Yoichi Suzuki

    BMC medical education　19　(1)　297-297　2019/08/02

    DOI： 10.1186/s12909-019-1725-5 　

    More details Close

    BACKGROUND: Genome cohort studies are used to analyze interactions between genetic and environmental factors, providing valuable information for personalized healthcare. Large-scale and long-term cohort studies require a number of specially trained personnel, of whom those involved in obtaining informed consent play a vital role, especially during the initial phase of such studies. The Japanese Society of Human Genetics (JSHG) previously established a certification system for genome medical research coordinators (GMRCs) responsible for obtaining written consent via face-to-face explanation. Meanwhile, in the Tohoku Medical Megabank Organization (ToMMo), GMRCs are expected to play important roles not only in obtaining informed consent and conducting various assessments, but also in communicating with participants throughout the long-term follow-up. Based on the JSHG program, we therefore developed a specific education and training program for ToMMo GMRCs consisting of 17 lectures, one practical training session on the informed consent procedure, and written and interview examinations. Re-education workshops aimed at self-improvement are also carried out following certification. In this study, we evaluated the education and training program in terms of overall understanding, usefulness, and satisfaction using an anonymous questionnaire. METHODS: An anonymous questionnaire addressing each aspect of the education and training program (understanding, usefulness, and satisfaction) was distributed among 152 qualified ToMMo GMRCs. Responses were received from 94 participants (61.8%). RESULTS: There was a significant association between the level of overall understanding of lectures and medical qualification (nurse or clinical laboratory technologist), but not with age or educational background. The level of understanding and overall usefulness were lower in sessions related to genetics and epidemiology than those dealing with ToMMo practices. In the re-education workshops, GMRCs showed a preference for and hoped to learn more about both background knowledge and research progress in the ToMMo. CONCLUSIONS: The results of our questionnaire suggest that not all ToMMo GMRCs are able to understand everything during the initial education and training program, especially in terms of genomic medicine. Continuous re-education is therefore vital in improving knowledge, skills and motivation, and preparing GMRCs for a specialist role in community-based personalized healthcare.

  379. Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes

    Wen-Yi Yang, Jesus D. Melgarejo, Lutgarde Thijs, Zhen-Yu Zhang, Jose Boggia, Fang-Fei Wei, Tine W. Hansen, Kei Asayama, Takayoshi Ohkubo, Jorgen Jeppesen, Eamon Dolan, Katarzyna Stolarz-Skrzypek, Sofia Malyutina, Edoardo Casiglia, Lars Lind, Jan Filipovsky, Gladys E. Maestre, Yan Li, Ji-Guang Wang, Yutaka Imai, Kalina Kawecka-Jaszcz, Edgardo Sandoya, Krzysztof Narkiewicz, Eoin O'Brien, Peter Verhamme, Jan A. Staessen, B. Mujaj, N. Cauwenberghs, T. Kuznetsova, W. -Y. Yang, C. -G. Yu, C. -S. Sheng, Q. -F. Huang, J. Seidlerova, M. Ticha, H. Ibsen, S. Rasmussen, C. Torp-Pedersen, A. Pizzioli, V. Tikhonoff, J. Hashimoto, H. Hoshi, R. Inoue, M. Kikuya, H. Metoki, T. Obara, H. Satoh, K. Totsune, N. Gilis-Malinowska, A. Adamkiewicz-Piejko, M. Cwynar, J. Gasowski, T. Grodzicki, W. Lubaszewski, A. Olszanecka, B. Wizner, W. Wojciechowska, J. Zyczkowska, Y. Nikitin, E. Pello, G. Simonova, M. Voevoda, B. Andren, L. Berglund, K. Bjorklund-Bodegard, B. Zethelius, M. Bianchi, V. Moreira, C. Schettini, E. Schwedt, H. Senra

    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION　322　(5)　409-420　2019/08

    DOI： 10.1001/jama.2019.9811 　

    ISSN： 0098-7484

    eISSN： 1538-3598

  380. 母子保健情報と学校保健情報の連係に基づく発育指標の関連

    上野 史彦, 小原 拓, 村上 慶子, 野田 あおい, 大柳 元, 石黒 真美, 目時 弘仁, 黒川 修行, 栗山 進一

    東北公衆衛生学会誌　(68)　20-20　2019/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  381. Association of Feeding Practice with Childhood Overweight and/or Obesity in Affected Areas Before and After the Great East Japan Earthquake. Peer-reviewed

    Kuniyoshi Y, Kikuya M, Matsubara H, Ishikuro M, Obara T, Kure S, Kuriyama S

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine　14　(6)　382-389　2019/07

    Publisher: Mary Ann Liebert Inc

    DOI： 10.1089/bfm.2018.0254 　

    ISSN： 1556-8253

    eISSN： 1556-8342

  382. Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study. International-journal Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Mami Ishikuro, Kasumi Sakurai, Tetsuro Hoshiai, Masatoshi Saito, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nariyasu Mano, Hirohito Metoki, Nobuo Yaegashi

    Congenital anomalies　59　(4)　110-117　2019/07

    DOI： 10.1111/cga.12293 　

    ISSN： 0914-3505

    More details Close

    We evaluated the relationship between preconception folic acid supplementation and the occurrence of neural tube defects (NTDs) in offspring, using data from the Japan Environment and Children's Study (a nationwide prospective birth cohort study) database. Of 92 269 participants with single pregnancies, 74 cases (offspring or fetuses) had NTDs, including 32 cases of spina bifida, 24 cases of anencephaly, and 19 cases of encephalocele. A total of 7634 participants (8.27%) used preconception folic acid supplementation, and of these, 621 (0.67%) also took in dietary folic acid at ≥480 μg/day. Multivariate logistic regression analyses demonstrated no association between preconception folic acid supplementation and NTDs in offspring or fetuses (odds ratio [OR] 0.622; 95% confidence interval [CI]: 0.226-1.713). Moreover, the participants who combined preconception folic acid supplement use with dietary folic acid intake ≥480 μg/day demonstrated no incidence of NTDs in offspring or fetuses. Our analysis is limited by the absence of the data on the daily amount of supplementary folic acid intake, requiring careful attention to the interpretation. Additional surveys are required in Japan to resolve those limitations for further comprehensive assessment.

  383. Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Masato Suzuka, Yasuko Ikeda-Sakai, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    Pharmacoepidemiology and drug safety　28　(6)　804-811　2019/06

    DOI： 10.1002/pds.4749 　

    ISSN： 1053-8569

    More details Close

    PURPOSE: To evaluate the prevalence and patterns of prescriptions of antiepileptic drugs (AEDs) to prenatal and postpartum women in Japan using a large administrative database. METHODS: The dates of pregnancy onset and delivery were estimated using published algorithms and infant birth months. The prevalence of prescribed AEDs, the maximum dose of some AEDs, and the frequency of potential combination therapy with AEDs were evaluated for the 180 days before pregnancy onset, during pregnancy, and at 180-day postpartum. RESULTS: In total, 33 941 pregnant women were eligible for analysis. At least one AED was prescribed to 225 women (66 per 10 000 deliveries) between 180 days before pregnancy and 180-day postpartum and for 135 women (40 per 10 000 deliveries) during pregnancy. The prevalence of AED prescription declined during the first and second trimesters and increased in the third trimester and postpartum. Valproate was the most frequently prescribed drug, followed by clonazepam, lamotrigine, and carbamazepine. Nine (18.4%) of the 49 women with at least one prescription record of valproate in the first trimester were prescribed more than 600 mg/day of valproate. Concerning potential combination therapy, 40 (12 per 10 000 deliveries) concurrently received two or more AEDs between 180 days before pregnancy and 180-day postpartum, respectively, 31 (9 per 10 000 deliveries) women received these drugs during pregnancy. CONCLUSIONS: Various AEDs were prescribed to pregnant Japanese women. Women of reproductive age should select the appropriate AED before becoming pregnant, depending on the risk benefit profile.

  384. Mother-to-infant bonding failure and intimate partner violence during pregnancy as risk factors for father-to-infant bonding failure at 1 month postpartum: an adjunct study of the Japan Environment and Children's Study. International-journal Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(16)　1-8　2019/04/15

    DOI： 10.1080/14767058.2018.1560414 　

    ISSN： 1476-7058

    More details Close

    OBJECTIVE: To survey the frequency and risk factors for father-to-infant lack of affection (LA) and anger/rejection (AR) bonding failure at 1 month postpartum. MATERIAL AND METHODS: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment & Children's Study. Bonding failure, psychological distress during pregnancy and postnatal depression symptoms were evaluated using the Japanese version of the Mother-Infant Bonding Scale (MIBS-J), the Kessler 6-item (K6) psychological distress scale and the Edinburgh Postnatal Depression Scale (EPDS-J). This study extracted relative factors based on approximately 10% occupancy of the total high scores in MIBS-J subscales as a cut-off for bonding failure. The cut-off scores on the paternal EPDS-J were eight, on maternal EPDS-J was 9, and on the K6 psychological distress scale score was 13. RESULTS: A total of 1008 couples who had single delivery were assessed at 1 month postpartum, respectively. The prevalence of paternal MIBS-J_LA scores ≥4 was 8.3%, MIBS-J_AR scores ≥3 was 7.9%, and EPDS-J scores ≥8 was 11.2%, respectively. In the multiple logistics analysis, paternal MIBS-J_LA scores ≥4 were significantly associated with maternal MIBS-J_LA score ≥3 (adjusted odds ratio (AOR) 2.814; 95% confidence interval (CI): 1.377-5.747), mental intimate partner violence (IPV) against the mother during pregnancy (AOR 2.176; 95% CI: 1.185-3.997), maternal K6 psychological distress scale score ≥13 (AOR 2.980; 95% CI: 1.317-6.745), paternal EPDS-J score ≥8 (AOR 3.227; 95% CI: 1.767-5.892), and a history of mental health disorder (AOR 4.125; 95% CI: 1.423-11.963). Paternal MIBS-J_AR scores ≥3 were significantly associated with maternal MIBS-J_AR scores ≥3 (AOR 5.082; 95% CI: 2.453-10.529), a history of physical IPV against the mother during pregnancy (AOR 5.230; 95% CI: 1.016-26.920), paternal K6 psychological distress scale score ≥13 (AOR 4.145; 95% CI: 1.311-13.107), and paternal EPDS-J scores ≥8 (AOR 4.479; 95% CI: 2.503-8.013). In Pearson's product moment correlation coefficient analyses between paternal and maternal MIBS-J score, MIBS-J_LA score was r = 0.2112, p < .0001, and MIBS-J_AR score was r = 0.3281, p < .0001. CONCLUSION: Father-to-infant lack of affection bonding failure was associated with mother-to-infant lack of affection bonding failure, mental IPV against mother during pregnancy, maternal psychological distress during pregnancy, paternal postpartum depression symptoms, and history of paternal mental health disorders. Father-to-infant anger/rejection bonding failure was associated with mother-to-infant anger/rejection bonding failure, physical IPV against mother during pregnancy, paternal psychological distress during pregnancy, and paternal postpartum depression symptoms. Since bonding failure is a risk factor for infant maltreatment, further investigations are recommended to fully assess these associations to resolve parent perinatal mental health issues for preventing father-to-infant bonding failure.

  385. Effect of Educational Interventions on Adverse Drug Reaction Reporting in a Cancer Institute in Japan: A Questionnaire Study Peer-reviewed

    Masami Tsuchiya, Akihisa Esashi, Taku Obara, Kyoko Inooka, Nariyasu Mano, Chizuko Takamura

    Hospital Pharmacy　54　(2)　93-99　2019/04

    DOI： 10.1177/0018578718769242 　

    ISSN： 0018-5787

    eISSN： 1945-1253

  386. Effect of Educational Interventions on Adverse Drug Reaction Reporting in a Cancer Institute in Japan: A Questionnaire Study. International-journal Peer-reviewed

    Masami Tsuchiya, Akihisa Esashi, Taku Obara, Kyoko Inooka, Nariyasu Mano, Chizuko Takamura

    Hospital pharmacy　54　(2)　93-99　2019/04

    DOI： 10.1177/0018578718769242 　

    More details Close

    Background: Limited data regarding knowledge and factors related to understanding the adverse drug reaction (ADR) reporting system of health care professionals are available in Japan. Objective: The objective of this study was to identify factors related to understanding the ADR reporting system in Miyagi Cancer Center and to find ways to increase the number and quality of ADR reports. Methods: Self-administered questionnaire surveys were administered before and after the educational meeting among health care professionals who were working in our hospital during the study period. Subanalyses restricted to nurses were also performed. Main Outcome Measure: Understanding ADR reporting system among healthcare professionals. Results: The percentage of respondents who understood the ADR reporting system in the questionnaire after the educational meeting was significantly higher than that in the questionnaire before the educational meeting. In the questionnaire after the educational meeting, multivariate logistic regression analysis found that having over 30 years of practical experience (odds ratio [OR], 3.852; 95% confidence interval [CI], 1.228-12.081 for 20-29 years, 7.695; 1.650-35.881 for over 30 years), being a physician (8.071; 1.923-33.878), being a pharmacist (18.357; 3.847-87.585), and participating in the educational meeting (5.111; 1.700-15.365) were factors associated with understanding the ADR reporting system. Multivariate logistic regression analysis of the questionnaire results before the educational meeting among nurses showed that working at outpatient departments (8.330; 3.008-23.069) was significantly and independently associated with understanding the ADR reporting system. Conclusions: The present study demonstrated that many years of practical experience, profession (physicians, pharmacists), and educational interventions were associated with good understanding of the ADR reporting system among health care professionals.

  387. Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. International-journal Peer-reviewed

    Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Hirotaka Hamada, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　42　(4)　558-566　2019/04

    DOI： 10.1038/s41440-019-0206-x 　

    ISSN： 0916-9636

    More details Close

    Smoking during pregnancy is a risk factor for various adverse birth outcomes but lowers the risk of preeclampsia. Cardiovascular adaptations might underlie these associations. We examined the association of maternal smoking with the risk of hypertensive disorders of pregnancy (HDP) in a low-risk population-based cohort of 76,303 pregnant women. This study was a part of the Japan Environment and Children's Study. Smoking status was assessed using questionnaires completed by participants. Information about HDP was assessed using questionnaires completed by doctors. Compared with that for women who did not smoke, women who continued smoking >10 cigarettes per day during pregnancy had a significantly higher risk of developing HDP (odds ratio: 1.58, 95% confidence interval: 1.11-2.25). In multivariate analyses with adjustment for possible confounding factors, the association still remained (odds ratio: 1.51, 95% confidence interval: 1.04-2.19). When we regarded the number of cigarettes as a continuous variable, there was a linear association between the number of cigarettes and risk of HDP, with an odds ratio of 1.02 per cigarette per day (95% confidence interval: 1.00-1.04). Smoking a greater number of cigarettes was associated with a higher risk of HDP after adjustment for possible confounding factors. Cigarette smoking cessation may avoid the complications of HDP. Our findings suggest that, in addition to the risk of small-for-gestational-age children, an increased risk of HDP should be considered in the management of pregnant women who smoke cigarettes.

  388. The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. International-journal Peer-reviewed

    Hiromitsu Hattori, Akane Kitamura, Fumiaki Takahashi, Norio Kobayashi, Akiko Sato, Naoko Miyauchi, Hidekazu Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi, Kunihiko Nakai, Takahiro Arima

    Reproductive biology and endocrinology : RB&E　17　(1)　27-27　2019/02/22

    DOI： 10.1186/s12958-019-0471-1 　

    More details Close

    BACKGROUND: Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the association between blastocyst transfer and SSR and MZT, considering potential parental confounders. METHODS: The Japan Environment and Children's Study is a large, nationwide longitudinal birth cohort study funded by the Ministry of the Environment of Japan. We used this large dataset, including 103,099 pregnancies, to further investigate the association between blastocyst transfer, SSR and MZT, using spontaneously conceived pregnancies, non-assisted reproductive technology (non-ART) treatment (intrauterine insemination and ovulation induction with timed intercourse) and cleavage stage embryo transfer for comparison. We evaluated the association with each group, the SSR, and the frequency of MZT, calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses, adjusting for potential parental confounders such as basic health and socioeconomic status. RESULTS: For each group (spontaneous conception vs. non-ART treatment vs. cleavage stage embryo transfer vs. blastocyst transfer), the percentages of males were 51.3% vs 50.7% vs 48.9% vs 53.4% and the monozygotic twinning rates per pregnancy were 0.27% vs 0.11% vs 0.27% vs 0.99% respectively. Multivariate logistic regression analyses indicated that blastocyst transfer was significantly associated with a higher SSR and higher incidence of MZT than the other three groups (SSR: AOR 1.095, 95% CI1.001-1.198; MZT: AOR 4.229, 95% CI 2.614-6.684). CONCLUSIONS: There are significant relationships between blastocyst transfer and SSR imbalance and a higher occurrence of MZT.

  389. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. International-journal Peer-reviewed

    Junichi Sugawara, Daisuke Ochi, Riu Yamashita, Takafumi Yamauchi, Daisuke Saigusa, Maiko Wagata, Taku Obara, Mami Ishikuro, Yoshiki Tsunemoto, Yuki Harada, Tomoko Shibata, Takahiro Mimori, Junko Kawashima, Fumiki Katsuoka, Takako Igarashi-Takai, Soichi Ogishima, Hirohito Metoki, Hiroaki Hashizume, Nobuo Fuse, Naoko Minegishi, Seizo Koshiba, Osamu Tanabe, Shinichi Kuriyama, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Satoshi Hiyama, Masao Nagasaki

    BMJ open　9　(2)　e025939　2019/02/19

    DOI： 10.1136/bmjopen-2018-025939 　

    More details Close

    PURPOSE: A prospective cohort study for pregnant women, the Maternity Log study, was designed to construct a time-course high-resolution reference catalogue of bioinformatic data in pregnancy and explore the associations between genomic and environmental factors and the onset of pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes mellitus and preterm labour, using continuous lifestyle monitoring combined with multiomics data on the genome, transcriptome, proteome, metabolome and microbiome. PARTICIPANTS: Pregnant women were recruited at the timing of first routine antenatal visits at Tohoku University Hospital, Sendai, Japan, between September 2015 and November 2016. Of the eligible women who were invited, 65.4% agreed to participate, and a total of 302 women were enrolled. The inclusion criteria were age ≥20 years and the ability to access the internet using a smartphone in the Japanese language. FINDINGS TO DATE: Study participants uploaded daily general health information including quality of sleep, condition of bowel movements and the presence of nausea, pain and uterine contractions. Participants also collected physiological data, such as body weight, blood pressure, heart rate and body temperature, using multiple home healthcare devices. The mean upload rate for each lifelog item was ranging from 67.4% (fetal movement) to 85.3% (physical activity), and the total number of data points was over 6 million. Biospecimens, including maternal plasma, serum, urine, saliva, dental plaque and cord blood, were collected for multiomics analysis. FUTURE PLANS: Lifelog and multiomics data will be used to construct a time-course high-resolution reference catalogue of pregnancy. The reference catalogue will allow us to discover relationships among multidimensional phenotypes and novel risk markers in pregnancy for the future personalised early prediction of pregnancy complications.

  390. Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Zen Watanabe, Hidekazu Nishigori, Kaou Tanoue, Kosuke Tanaka, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Masatoshi Saito, Masahito Tachibana, Ikuma Fujiwara, Takahiro Arima, Takashi Takeda, Shinichi Kuriyama, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Journal of affective disorders　245　475-483　2019/02/15

    DOI： 10.1016/j.jad.2018.11.061 　

    ISSN： 0165-0327

    More details Close

    BACKGROUND: Dysmenorrhea influences emotional distress as well as physical suffering in young non-pregnant women. The aim of this study was to assess the potential association between preconception dysmenorrhea and the development of psychological distress during pregnancy. METHODS: This study was a part of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study conducted between 2011 and 2014 in Japan. A total of 87,102 pregnant Japanese women with no psychological distress (Kessler 6-item psychological distress scale [K6] score ≤ 12) in early pregnancy were eligible. Among these, 7626 had mild and 1638 had severe preconception dysmenorrhea. The prevalence and risk of maternal psychological distress (K6 scores ≥ 13) in the second or third trimester were compared among preconception dysmenorrhea severity groups. RESULTS: A higher percentage of women with mild (2.6%) or severe preconception dysmenorrhea (3.6%) suffered psychological distress during pregnancy compared to that in women without dysmenorrhea (2.1%). A multilevel logistic regression model, adjusting for baseline characteristics and the K6 score at enrollment, showed that the severity of dysmenorrhea was associated with psychological distress (mild dysmenorrhea: adjusted odds ratio [aOR], 1.154; 95% confidence interval [95% CI], 0.980-1.359; and severe dysmenorrhea: aOR, 1.457; 95% CI, 1.087-1.951). LIMITATIONS: Information about dysmenorrhea was obtained during early pregnancy. The JECS did not have clear diagnostic criteria for dysmenorrhea. CONCLUSIONS: Preconception dysmenorrhea is associated with an elevated incidence of psychological distress during pregnancy. Additionally, expectant mothers with a history of severe dysmenorrhea symptoms before pregnancy have a higher risk of developing psychological distress.

  391. The prevalence and risk factors for postpartum depression symptoms of fathers at one and 6 months postpartum: an adjunct study of the Japan Environment & Children's Study. International-journal Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(16)　1-8　2019/01/04

    DOI： 10.1080/14767058.2018.1560415 　

    More details Close

    OBJECTIVE: To survey prevalence and risk factors for paternal postpartum depression symptoms at one and 6 months postpartum in Japan. MATERIAL AND METHODS: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment and Children's Study. Postpartum depression symptoms were evaluated using the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS-J). The cut-off scores on the paternal EPDS-J were eight and on maternal EPDS-J was nine, respectively. The multivariate logistic regression included an adjustment for paternal age, maternal age, the number of children in the family, family structure, paternal employment, paternal academic history, household income, paternal smoking status, paternal history of mental health disorders, the Kessler 6-item psychological distress scale (K6) score during pregnancy, infertility treatment, paternal mental intimate partner violence (IPV) during pregnancy, paternal physical IPV during pregnancy, the sex of the newborn, congenital anomalies of the newborn, infant disease under medical treatment, returning to the maternal parent's house to give birth or take care of infant, the father's history of disease or injury that required medical treatment, paternity leave, and the EPDS-J for mothers. RESULTS: A total of 1023 and 1330 fathers and their spouse who had a single delivery were assessed at one and 6 months postpartum, respectively. The prevalence of paternal EPDS-J scores ≥8 was 11.2 and 12.0% at one and 6 months postpartum, respectively. In the multiple logistics analysis, paternal EPDS-J scores ≥8 at 1 month postpartum was significantly associated with history of mental health disorders (adjusted odds ratio (AOR) 2.825; 95% confidence interval (CI): 1.047-7.623), K6 score ≥13 during pregnancy (AOR 4.116; 95% CI: 1.598-10.599), household income <4000 × 103 yen (AOR 1.799; 95% CI: 1.072-3.021), and infant disease under medical treatment (AOR 1.720; 95% CI: 1.015-2.915). Paternal EPDS-J scores ≥8 at 6 months postpartum was significantly associated with K6 scores ≥13 during pregnancy (AOR 4.621; 95% CI: 2.113-10.107), unemployment (AOR 3.751; 95% CI: 1.739-8.091) and maternal EPDS-J scores ≥9 (AOR 2.460; 95% CI: 1.514-3.996). CONCLUSION: The prevalence of paternal postpartum depression symptoms were 11.2 and 12.0% at one and 6 months postpartum. Paternal postpartum depression symptoms at 1 month postpartum were associated with the history of mental health disorders, psychological distress during pregnancy, low income, and infant disease under medical treatment. Paternal postpartum depression symptoms at 6 months postpartum were associated with psychological distress during pregnancy, unemployment, and maternal postpartum depression. It is important to consider the paternal postpartum depression symptoms, and further enlightenment regarding these issues is recommended in Japan.

  392. Responder Analysis of Daikenchuto Treatment for Constipation in Poststroke Patients: A Subanalysis of a Randomized Control Trial

    Ryutaro Arita, Takehiro Numata, Shin Takayama, Taku Obara, Akiko Kikuchi, Minoru Ohsawa, Akifumi Suzuki, Takashi Yokota, Mizue Kusaba, Nobuo Yaegashi, Tadashi Ishii

    Journal of Evidence-Based Integrative Medicine　24　2019

    DOI： 10.1177/2515690X19889271 　

    eISSN： 2515-690X

  393. Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. International-journal Peer-reviewed

    Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Journal of hypertension　37　(1)　206-215　2019/01

    DOI： 10.1097/HJH.0000000000001846 　

    ISSN： 0263-6352

    More details Close

    OBJECTIVES: Although a twin pregnancy is a risk factor for hypertensive disorders of pregnancy, studies investigating longitudinal blood pressure changes during twin pregnancies are uncommon. The aims of this study were to evaluate the longitudinal blood pressure changes during twin pregnancies and to compare blood pressure levels between twin and singleton pregnancies. METHODS: Five hundred dichorionic diamniotic twin, 240 monochorionic diamniotic twin, and 80 775 singleton pregnancies were included in this Japanese prospective birth cohort study. A marginal model was applied to evaluate the SBP, DBP, and mean arterial pressure levels during early gestation, mid-gestation, and late gestation. RESULTS: The blood pressure levels fell from early-to-mid-gestation and rose after mid-gestation in the dichorionic and monochorionic diamniotic twin pregnancies. The SBP and mean arterial pressure levels during early gestation and the DBP and mean arterial pressure levels during late gestation were higher in the dichorionic diamniotic twin pregnancies than those in the singleton pregnancies. The blood pressure levels in the monochorionic diamniotic twin pregnancies were higher than those in the singleton pregnancies at each gestational stage, except for the SBP during late gestation. CONCLUSION: Although the longitudinal blood pressure changes during twin pregnancies were similar to those during singleton pregnancies, the blood pressure levels during twin pregnancies were higher. Further studies that examine the associations between the longitudinal blood pressure changes during pregnancy and the perinatal outcomes in twin pregnancies are necessary.

  394. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study. International-journal Peer-reviewed

    Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Hypertension research : official journal of the Japanese Society of Hypertension　42　(1)　85-94　2019/01

    DOI： 10.1038/s41440-018-0124-3 　

    More details Close

    This study examined the association between maternal alcohol consumption during pregnancy and hypertensive disorders of pregnancy in the Japan Environment and Children's Study, a nationwide birth cohort study. A total of 76 940 pregnant women were included in the analysis. Information about alcohol consumption during pregnancy was obtained using two questionnaires: T1 and T2. The mean (standard deviation) gestational age in the T1 and T2 questionnaires were 16.5 (5.8) and 27.9 (3.7) weeks, respectively. Alcohol consumption was considered as an exposure, hypertensive disorders of pregnancy as an outcome, and possible confounding factors were included in a generalized linear mixed-effects model with a logit link function. Among the study subjects, 2 348 (3.1%) women developed hypertensive disorders of pregnancy. Compared with 25 300 women who never drank alcohol, 43 women who drank alcohol according to the T1 questionnaire and continued to drink ≥150 g ethanol/week according to the T2 questionnaire had significantly higher odds of hypertensive disorders of pregnancy. The adjusted odds ratio was 3.98 (95% confidence interval [CI], 1.33-11.9). In conclusion, alcohol consumption of ≥150 g ethanol/week during pregnancy is better avoided because of the high odds of developing hypertensive disorders of pregnancy. It may be meaningful that healthcare providers confirm information about alcohol consumption during pregnancy. Moreover, discontinuation of alcohol consumption is recommended to prevent the onset of hypertensive disorders of pregnancy in Japan.

  395. Development and evaluation of a home nocturnal blood pressure monitoring system using a wrist-cuff device. International-journal Peer-reviewed

    Yutaka Imai, Kei Asayama, Seisuke Fujiwara, Kanako Saito, Hironori Sato, Toshikazu Haga, Michihiro Satoh, Takahisa Murakami, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Ryusuke Inoue, Takayoshi Ohkubo

    Blood pressure monitoring　23　(6)　318-326　2018/12

    DOI： 10.1097/MBP.0000000000000351 　

    ISSN： 1359-5237

    More details Close

    OBJECTIVE: The conventional nocturnal blood pressure monitoring (NBPM) systems can disturb sleep and lead to false measurements. The present study compared the validity and acceptability of a newly developed wrist-cuff system with that of the conventional upper arm-cuff system for NBPM. PARTICIPANTS AND METHODS: Home blood pressure (BP) and pulse rate (PR) were measured in hypertensive patients (n=57) every 30 min at night using a wrist-cuff system and at 2 am (fixed time) and 4 h after going to bed (flexible time) using an upper arm-cuff system. The nocturnal BPs with the wrist-cuff system at 2 am and at 4 h after going to bed were selected from the measurements taken every 30 min at night. The same systems were used to measure the morning and evening home BP and PR, after rising and before going to bed. Measurements were taken for two nights separately for each system. BP, PR, sleep quality, and the perception of several stimuli during NBPM were compared between the two systems. Systolic BP/diastolic BP (DBP) in the supine position at 2 am and at 4 h after going to bed were corrected by the mean difference between the wrist-cuff and the arm-cuff systems. RESULTS: Compared with the arm-cuff system, the wrist-cuff system had significantly lower systolic BP (mean±SD: 106.3±13.4 vs. 109.8±10.8 mmHg, P<0.05), DBP (59.4±11.0 vs. 64.5±7.8 mmHg, P<0.005), and PR (53.8±7.1 vs. 60.5±8.1 bpm, P<0.0005) at 2 am and significantly lower DBP (60.2±10.3 vs. 66.0±9.8 mmHg, P<0.005) and PR (53.6±7.4 vs. 60.9±8.5 bpm, P<0.0005) at 4 h after going to bed. Among the participants, sleep disturbance during NBPM was reported in less than 20% with the wrist-cuff system and in 70% with the arm-cuff system. A significantly higher rate of participants who wore the wrist-cuff system reported that they were not bothered by various stimuli, such as noise, during NBPM. DISCUSSION: The newly developed wrist-cuff home NBPM system provided information on BP as a function of time, especially at night, with minimal sleep disturbance and with more frequent BP measurements.

  396. Antihypertensives prescribed for pregnant women in Japan: Prevalence and timing determined from a database of health insurance claims. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Keiko Miyakoda, Mami Ishikuro, Hirohito Metoki, Takayoshi Ohkubo, Junichi Sugawara, Nobuo Yaegashi, Manabu Akazawa, Shinichi Kuriyama, Nariyasu Mano

    Pharmacoepidemiology and drug safety　27　(12)　1325-1334　2018/12

    DOI： 10.1002/pds.4654 　

    ISSN： 1053-8569

  397. 薬剤師に求められる医薬品安全性情報の創出

    小原 拓, 眞野 成康, 堀 雄史

    日本医療薬学会年会講演要旨集　28　337-341　2018/11/23

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.28.0_337 　

    eISSN： 2424-2470

  398. Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods. International-journal Peer-reviewed

    Taku Obara, Mami Ishikuro, Gen Tamiya, Masao Ueki, Chizuru Yamanaka, Satoshi Mizuno, Masahiro Kikuya, Hirohito Metoki, Hiroko Matsubara, Masato Nagai, Tomoko Kobayashi, Machiko Kamiyama, Mikako Watanabe, Kazuhiko Kakuta, Minami Ouchi, Aki Kurihara, Naru Fukuchi, Akihiro Yasuhara, Masumi Inagaki, Makiko Kaga, Shigeo Kure, Shinichi Kuriyama

    Scientific reports　8　(1)　14840-14840　2018/10/04

    DOI： 10.1038/s41598-018-33110-w 　

    More details Close

    We investigated whether machine learning methods could potentially identify a subgroup of persons with autism spectrum disorder (ASD) who show vitamin B6 responsiveness by selected phenotype variables. We analyzed the existing data from our intervention study with 17 persons. First, we focused on signs and biomarkers that have been identified as candidates for vitamin B6 responsiveness indicators. Second, we conducted hypothesis testing among these selected variables and their combinations. Finally, we further investigated the results by conducting cluster analyses with two different algorithms, affinity propagation and k-medoids. Statistically significant variables for vitamin B6 responsiveness, including combination of hypersensitivity to sound and clumsiness, and plasma glutamine level, were included. As an a priori variable, the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) scores was also included. The affinity propagation analysis showed good classification of three potential vitamin B6-responsive persons with ASD. The k-medoids analysis also showed good classification. To our knowledge, this is the first study to attempt to identify subgroup of persons with ASD who show specific treatment responsiveness using selected phenotype variables. We applied machine learning methods to further investigate these variables' ability to identify this subgroup of ASD, even when only a small sample size was available.

  399. 260. The Great East Japan Earthquake and hypertensive disorders of pregnancy: The TMM BirThree Cohort Study

    Taku Obara, Takuma Usuzaki, Chizuru Yamanaka, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Masahiro Kikuya, Hirohito Metoki, Shinichi Kuriyama

    Pregnancy Hypertension　13　S112-S113　2018/10/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.preghy.2018.08.332 　

    ISSN： 2210-7789

    More details Close

    Introduction We experienced a devastating disaster, the Great East Japan Earthquake, in 2011. Some previous studies showed that disasters affected maternal blood pressure and their health. Its longer effect on pregnant women is necessary to investigate. Objective The purpose of this present study was to investigate if maternal disaster exposure affected their blood pressure. Methods The relationship between disaster exposure and maternal outcomes was retrospectively analyzed using the data of 4426 women who were recruited to the Tohoku Medical Megabank Birth and Three-generation Cohort Study, which was conducted in the years 2013–2017. Women were classified into three groups by the severity of the destruction of their house: group A, no destruction/did not live in the disaster-hit area; group B, half/a part of the house was destroyed; and group C, house totally/mostly destroyed. Multiple logistic regression analysis was performed to investigate the relationship between disaster exposure and hypertensive disorders of pregnancy, adjusting for body mass index, age, smoking, drinking, income, parity, and multiple pregnancy. Results Of 4,426 women eligible for the analyses, the houses of 489 women (11.0%) were totally or mostly destroyed, and the houses of 1706 women (38.5%) were half or partly destroyed. Those whose houses were not destroyed or did not live in the area affected by the disaster included 2,231 women (50.4%). The prevalence of hypertensive disorders of pregnancy in groups B and C were 0.82 and 1.47 times higher than in group A, but there was no statistical significance. Discussion Involvement in a disaster event about three to six years before pregnancy was not related to a higher prevalence of hypertensive disorders of pregnancy.

  400. 院内副作用事例の一元管理方法の構築 電子カルテシステムのeXChart機能の活用 Peer-reviewed

    菊池 大輔, 小原 拓, 三浦 良祐, 渡辺 善照

    医薬品相互作用研究　42　(3)　192-197　2018/10

    Publisher: 医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    電子カルテのeXChartを活用した院内副作用事例の一元管理方法の評価を行った。評価期間中に報告された院内副作用報告は24件であり、副作用の重篤度に関しては重篤が4件、非重篤が6件、不明が14件であった。院内副作用報告の報告者はすべて薬剤師であり、報告者の内訳は病棟担当薬剤師8名、化学療法担当薬剤師2名であった。PMDAへ副作用報告を行ったのは5件であった。内訳はエクリズマブ注による敗血症ショックが1件、ドセタキセル注によるアナフィラキシーショックが1例、レンバチニブカプセルによる尿蛋白3+が1件、アモキシシリン・クラブラン酸カリウム配合錠、スルバクタムナトリウム注による抗菌薬関連出血性大腸炎疑いが1件、アモキシシリン・クラブラン酸カリウム配合錠による抗菌薬関連出血性大腸炎疑いが1件であった。

  401. Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Peer-reviewed

    Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama

    The Tohoku journal of experimental medicine　246　(2)　97-105　2018/10

    DOI： 10.1620/tjem.246.97 　

    ISSN： 0040-8727

    More details Close

    Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings. To obtain informed consent, we were careful of explaining clearly the complex reasons as well as drawing people's attention. By the end of March 2017, the number of invitation letters distributed to family members through the pregnant women was 23,806, including 18,702 grandparents. Among the grandparents who received invitation letters, 2,935 (15.7%) responded to us. Furthermore, some grandparents were asked to provide informed consent with other family members by staff at maternal clinics or Community Support Centers, and others directly booked Community Support Centers without responding to the invitation letter. Grandparents joined the study anytime during mother's maternal check-ups or delivery. Overall, 8,054 grandparents participated in our birth cohort study. The setting in which most grandparents were recruited was our own facilities. Importantly, both paternal and maternal grandparents more frequently participated in the study if the father also participated. In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents.

  402. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. International-journal Peer-reviewed

    Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

    Allergology international : official journal of the Japanese Society of Allergology　67　(4)　481-486　2018/10

    DOI： 10.1016/j.alit.2018.02.009 　

    ISSN： 1323-8930

    More details Close

    BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire. Clinical ranges of Strengths and Difficulties Questionnaire (SDQ) total difficulties scores and four SDQ subcategories of emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems were defined as scores ≥16, ≥5, ≥5, ≥7, and ≥5, respectively. RESULTS: The mean SDQ total difficulties score significantly increased as eczema status worsened (all P ≤ 0.004 for trend). The OR of scores in the clinical range for SDQ total difficulties were 1.51 (95% CI, 1.31-1.74) for mild/moderate eczema and 2.63 (95% CI, 1.91-3.63) for severe eczema (P < 0.001 for trend), adjusted for sex, school grade, current wheeze, and disaster-related factors, using normal eczema as a reference. The association between severity of eczema and four SDQ subcategories showed a similar trend (all P ≤ 0.017 for trend). CONCLUSIONS: We found a significant association between severity of eczema and mental health problems. The presence of eczema was associated with four SDQ subcategories.

  403. Predictive power of home blood pressure indices at baseline and during follow-up in hypertensive patients: HOMED-BP study. International-journal Peer-reviewed

    Daisuke Watabe, Kei Asayama, Tomohiro Hanazawa, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo

    Hypertension research : official journal of the Japanese Society of Hypertension　41　(8)　622-628　2018/08

    DOI： 10.1038/s41440-018-0050-4 　

    ISSN： 0916-9636

    More details Close

    We compared the predictive power for a major adverse cardiovascular event (MACE) of four home blood pressure (BP) indices (systolic BP, diastolic BP, mean BP, and pulse pressure (PP)) obtained at baseline before treatment and during the on-treatment follow-up period in 3147 patients with essential hypertension (women: 50.1%, mean age: 59.5 years). Associations between MACE and each index were determined using Cox proportional hazard models and the likelihood ratio (LR) test. During a median follow-up of 5.4 years, 46 patients experienced MACE, which was a composite of cardiovascular death, non-fatal stroke, and non-fatal myocardial infarction. The LR test showed that systolic, diastolic, and mean BP during follow-up was more closely associated with cardiovascular risk than the corresponding indices at baseline (LR χ2 for baseline versus follow-up: systolic BP, (6.0, P = 0.014) versus (11.3, P = 0.0008); diastolic BP, (0.4, P = 0.53) versus (12.4, P = 0.0004); mean BP, (3.2, P = 0.074) versus (15.0, P = 0.0001)), whereas neither PP at baseline nor that during follow-up was significantly associated with MACE risk. Among home BP indices during follow-up, mean BP further improved prediction models in which systolic or diastolic BP was already included (P ≤ 0.042), but neither systolic nor diastolic BP improved models with mean BP (P = 0.80). In addition to home systolic and diastolic BP, mean BP during follow-up period provides essential information in predicting future cardiovascular diseases, whereas its utilization should be further assessed by an intervention trial targeting mean BP levels.

  404. N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years - The Ohasama Study. Peer-reviewed

    Michihiro Satoh, Takahisa Murakami, Kei Asayama, Takuo Hirose, Masahiro Kikuya, Ryusuke Inoue, Megumi Tsubota-Utsugi, Keiko Murakami, Ayako Matsuda, Azusa Hara, Taku Obara, Ryo Kawasaki, Kyoko Nomura, Hirohito Metoki, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

    Circulation journal : official journal of the Japanese Circulation Society　82　(8)　2055-2062　2018/07/25

    DOI： 10.1253/circj.CJ-17-1227 　

    ISSN： 1346-9843

    More details Close

    BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been used for risk stratification in heart failure or acute coronary syndrome, but the beyond 5-year predictive value of NT-proBNP for stroke remains an unsettled issue in Asian patients. The aim of the present study was to clarify this point.Methods and Results:We followed 1,198 participants (33.4% men; mean age, 60.5±11.1 years old) in the Japanese general population for a median of 13.0 years. A first stroke occurred in 93 participants. Referencing previous reports, we stratified participants according to NT-proBNP 30.0, 55.0, and 125.0 pg/mL. Using the NT-proBNP <30.0 pg/mL group as a reference, adjusted HR for stroke (95% CI) in the NT-proBNP 30.0-54.9-pg/mL, 55.0-124.9-pg/mL, and ≥125.0-pg/mL groups were 1.92 (0.94-3.94), 1.77 (0.85-3.66), and 1.99 (0.86-4.61), respectively. With the maximum follow-up period set at 5 years, the hazard ratio of the NT-proBNP≥125.0-pg/mL group compared with the <30.0-pg/mL group increased significantly (HR, 4.51; 95% CI: 1.03-19.85). On extension of the maximum follow-up period, however, the association between NT-proBNP and stroke risk weakened. CONCLUSIONS: NT-proBNP was significantly associated with an elevated stroke risk. Given, however, that the predictive power decreased with the number of years after NT-proBNP measurement, NT-proBNP should be re-evaluated periodically in Asian patients.

  405. Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients Peer-reviewed

    Miki Hosaka, Ryusuke Inoue, Michihiro Satoh, Daisuke Watabe, Tomohiro Hanazawa, Takayoshi Ohkubo, Kei Asayama, Taku Obara, Yutaka Imai, on behalf of The J-HOME-ALB Study group

    Clinical and Experimental Hypertension　40　(5)　468-475　2018/07/04

    Publisher: Taylor and Francis Ltd

    DOI： 10.1080/10641963.2017.1403617 　

    ISSN： 1525-6006 1064-1963

  406. Development of algorithms to determine the onset of pregnancy and delivery date using health care administrative data in a university hospital in Japan. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Keiko Miyakoda, Ryusuke Inoue, Tetsuro Hoshiai, Masatoshi Saito, Nobuo Yaegashi, Nariyasu Mano

    Pharmacoepidemiology and drug safety　27　(7)　751-762　2018/07

    DOI： 10.1002/pds.4444 　

    More details Close

    PURPOSE: To develop and assess algorithms to determine the onset of pregnancy and delivery date using health administrative data from a university hospital in Japan. METHODS: All women who were hospitalized in the maternity ward and had at least one pregnancy that ended with a delivery during the period of January 2014 and December 2015 were included in this study. The true delivery date was obtained from the electronic medical records and was used as a gold standard. The onset of pregnancy was calculated by subtracting the gestational age at birth from the delivery date based on the electronic medical records and was also used as a gold standard. The administrative data-based algorithms to identify (1) the onset of pregnancy estimated from the gestational age recorded as part of a diagnosis during a specific visit and (2) the delivery date estimated using the delivery-related diagnosis, procedure, or prescription were compared with the gold-standard data. RESULTS: Of the 1705 women included in this study, the onset of pregnancy was determined in 1704 subjects with 1582 (92.8%) within ± 7 days from the gold-standard date of pregnancy onset. The delivery date was determined in 1654 subjects, and 1594 (96.4%) were within ± 7 days before the true delivery date using the algorithm of "selected" diagnosis and a surgical procedure followed by some other delivery-related data. CONCLUSIONS: The algorithms developed in this study are expected to accelerate future studies for real-world exposure and quantify drug safety during pregnancy using Japanese health care administrative databases.

  407. 医薬品安全性情報報告の基準と手順を考える 医薬品・医療機器等安全性情報報告制度を活用するために

    小原 拓, 眞野 成康

    日本医薬品情報学会総会・学術大会講演要旨集　21回　66-66　2018/06

    Publisher: (一社)日本医薬品情報学会

  408. 添付文書および医薬品インタビューフォームにおける血液透析患者への投与方法に関する記載内容調査

    八島 一史, 小原 拓, 中川 直人, 中曽根 正皓, 大柳 元, 荒木 勇太, 細谷 絵美, 前川 麻央, 前嶋 隆弘, 高橋 阿希子, 木皿 重樹, 眞野 成康

    医薬品相互作用研究　42　(2)　111-115　2018/06

    Publisher: 医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    CKD診療ガイド2012「付表:腎機能低下時の薬剤投与量」の透析性の項目に「○」と記載されている107成分を含有する先発医薬品を対象とした。透析除去率および透析による体内動態指標の変化についての記載があった薬剤は、それぞれ77剤(72.0%)および48剤(44.9%)であった。血液透析患者への推奨投与量について記載があった薬剤は24剤(22.4%)で、禁忌とされている薬剤が9剤(8.4%)、他の投与経路を推奨している薬剤が1剤(0.9%)であった。禁忌および他の投与経路の推奨を含め、血液透析患者への推奨投与量について何らかの記載があった薬剤は34剤(31.8%)であった。透析除去率、透析による体内動態指標の変化および血液透析患者への推奨投与量のいずれの項目においても、有意な経年的改善を認めた。薬効分類別の比較では、透析による体内動態指標の変化についての記載率が感染症治療薬で有意に高かった。透析除去率および血液透析患者への推奨投与量は、共に発売年がそれらの記載率に関連する因子であると考えられた。透析による体内動態指標の変化は、薬効分類(感染症治療薬/感染症治療薬以外)と有意な関連を認めた。

  409. 医薬品情報データベースを活用したこれからの薬剤師業務〜Web上のオープンデータをどう活かすか〜 医薬品副作用データベースを薬剤師業務に生かすには JADERを例に Peer-reviewed

    土屋 雅美, 小原 拓, 眞野 成康, 高村 千津子

    日本医薬品情報学会総会・学術大会講演要旨集　21回　64-64　2018/06

    Publisher: (一社)日本医薬品情報学会

  410. Defined Daily Doseと比較した日本の降圧薬処方用量 レセプトデータに基づく検討 Peer-reviewed

    佐藤 倫広, 村上 任尚, 小原 拓, 辰巳 友佳子, 高畠 恭介, 原 梓, 浅山 敬, 今井 潤, 大久保 孝義, 目時 弘仁

    日本医薬品情報学会総会・学術大会講演要旨集　21回　125-125　2018/06

    Publisher: (一社)日本医薬品情報学会

  411. Association Between Amplitude of Seasonal Variation in Self-Measured Home Blood Pressure and Cardiovascular Outcomes: HOMED-BP (Hypertension Objective Treatment Based on Measurement By Electrical Devices of Blood Pressure) Study. International-journal Peer-reviewed

    Tomohiro Hanazawa, Kei Asayama, Daisuke Watabe, Ayumi Tanabe, Michihiro Satoh, Ryusuke Inoue, Azusa Hara, Taku Obara, Masahiro Kikuya, Kyoko Nomura, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo

    Journal of the American Heart Association　7　(10)　2018/05/04

    DOI： 10.1161/JAHA.117.008509 　

    More details Close

    BACKGROUND: The clinical significance of long-term seasonal variations in self-measured home blood pressure (BP) has not been elucidated for the cardiovascular disease prevention. METHODS AND RESULTS: Eligible 2787 patients were classified into 4 groups according to the magnitude of their seasonal variation in home BP, defined as an average of all increases in home BP from summer (July-August) to winter (January-February) combined with all decreases from winter to summer throughout the follow-up period, namely inverse- (systolic/diastolic, <0/<0 mm Hg), small- (0-4.8/0-2.4 mm Hg), middle- (4.8-9.1/2.4-4.5 mm Hg), or large- (≥9.1/≥4.5 mm Hg) variation groups. The overall cardiovascular risks illustrated U-shaped relationships across the groups, and hazard ratios for all cardiovascular outcomes compared with the small-variation group were 3.07 (P=0.004) and 2.02 (P=0.041) in the inverse-variation group and large-variation group, respectively, based on systolic BP, and results were confirmatory for major adverse cardiovascular events. Furthermore, when the summer-winter home BP difference was evaluated among patients who experienced titration and tapering of antihypertensive drugs depending on the season, the difference was significantly smaller in the early (September-November) than in the late (December-February) titration group (3.9/1.2 mm Hg versus 7.3/3.1 mm Hg, P<0.001) as well as in the early (March-May) than in the late (June-August) tapering group (4.4/2.1 mm Hg versus 7.1/3.4 mm Hg, P<0.001). CONCLUSIONS: The small-to-middle seasonal variation in home BP (0-9.1/0-4.5 mm Hg), which may be partially attributed to earlier adjustment of antihypertensive medication, were associated with better cardiovascular outcomes.

  412. Prevalence of Therapeutic Drug Monitoring for Lithium and the Impact of Regulatory Warnings: Analysis Using Japanese Claims Database. International-journal

    Nobuhiro Ooba, Daisuke Tsutsumi, Naoko Kobayashi, Shinji Hidaka, Hiroyuki Hayashi, Taku Obara, Michihiro Satoh, Kiyoshi Kubota, Noriyasu Fukuoka

    Therapeutic drug monitoring　40　(2)　252-256　2018/04

    DOI： 10.1097/FTD.0000000000000483 　

    More details Close

    BACKGROUND: Therapeutic drug monitoring (TDM) for lithium is recommended in guidelines; however, the prevalence of TDM for lithium is seldom reported. We have therefore investigated the prevalence of TDM for lithium and evaluated the impact of the regulatory warnings requiring routine TDM for lithium. METHODS: Monthly claims data covering around 1.7 million persons aged 20-74 years old during the period January 1, 2005, and March 31, 2015, were evaluated. All patients who had at least one prescription for lithium were selected and included to calculate the annual prevalence of TDM for lithium. Also we assessed whether the 2 regulatory warnings requiring routine TDM for lithium and issued in April 2012 and September 2012 had an impact on TDM for lithium, using segmented regression analysis. RESULTS: Between 2005 and 2014, 136,956 prescriptions of lithium were issued to 5823 patients, and the annual prevalence of TDM for lithium was 14.9% (95% confidence interval, 14.7%-15.1%). The analysis revealed that the mean prevalence increased abruptly by 6.9% (P = 0.001) after the regulatory warning in April 2012, whereas that the warning in September 2012 decreased by 1.2% (P = 0.47). There was no significant change in trends of period prevalence after the warning in April 2012 (April 2012-August 2012) compared with prevalence before the warning (April 2010-March 2012). Similarly, no significant change was observed in the trends before (April 2012-August 2012) and after (September 2012-March 2014) the subsequent warning in September 2012. CONCLUSIONS: Results showed that the prevalence of TDM for lithium was low, although TDM for lithium was strongly recommended by the guidelines. Regulatory warnings requiring compliance with the measurement of blood levels during treatment with lithium, issued twice during the five-month period, were associated with an increase in the prevalence of TDM for lithium. However, the impact of the second warning was not remarkable compared with the first warning.

  413. Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: The Kakegawa cohort study. International-journal Peer-reviewed

    Hisashi Ohseto, Mami Ishikuro, Masahiro Kikuya, Taku Obara, Yuko Igarashi, Satomi Takahashi, Daisuke Kikuchi, Michiko Shigihara, Chizuru Yamanaka, Masako Miyashita, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Yuki Sato, Hirohito Metoki, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

    Journal of psychosomatic research　107　20-25　2018/04

    DOI： 10.1016/j.jpsychores.2018.01.013 　

    ISSN： 0022-3999

    More details Close

    OBJECTIVE: Metabolic syndrome and the presence of metabolic syndrome components are risk factors for cardiovascular disease (CVD). However, the association between personality traits and metabolic syndrome remains controversial, and few studies have been conducted in East Asian populations. METHODS: We measured personality traits using the Japanese version of the Eysenck Personality Questionnaire (Revised Short Form) and five metabolic syndrome components-elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose-in 1322 participants aged 51.1±12.7years old from Kakegawa city, Japan. Metabolic syndrome score (MS score) was defined as the number of metabolic syndrome components present, and metabolic syndrome as having the MS score of 3 or higher. We performed multiple logistic regression analyses to examine the relationship between personality traits and metabolic syndrome components and multiple regression analyses to examine the relationship between personality traits and MS scores adjusted for age, sex, education, income, smoking status, alcohol use, and family history of CVD and diabetes mellitus. We also examine the relationship between personality traits and metabolic syndrome presence by multiple logistic regression analyses. RESULTS: "Extraversion" scores were higher in those with metabolic syndrome components (elevated waist circumference: P=0.001; elevated triglycerides: P=0.01; elevated blood pressure: P=0.004; elevated fasting glucose: P=0.002). "Extraversion" was associated with the MS score (coefficient=0.12, P=0.0003). No personality trait was significantly associated with the presence of metabolic syndrome. CONCLUSIONS: Higher "extraversion" scores were related to higher MS scores, but no personality trait was significantly associated with the presence of metabolic syndrome.

  414. レセプトデータを利用した小児ADHD患者における処方実態の把握

    吉田 真貴子, 小原 拓, 菊地 紗耶, 菊地 正史, 山口 浩明, 眞野 成康

    日本薬学会年会要旨集　138年会　(4)　185-185　2018/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  415. 周辺施設へのアクセシビリティと産後うつとの関連 三世代コホート調査 Peer-reviewed

    永井 雅人, 水野 聖士, 石黒 真美, 宮下 真子, 山中 千鶴, 佐藤 ゆき, 松原 博子, 小原 拓, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    宮城県公衆衛生学会会誌　(50)　30-30　2018/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  416. 医薬品情報の薬薬連携を指向した病院ならびに薬局対象のアンケート調査と研修会開催の成果 平成28年度課題研究班成果報告 Peer-reviewed

    橋本 貴尚, 菊池 大輔, 新沼 佑美, 小原 拓, 村井 ユリ子, 畑中 貞雄, 栃窪 克行, 渡辺 善照

    医薬品情報学　19　(4)　158-171　2018/02

    Publisher: (一社)日本医薬品情報学会

    ISSN： 1345-1464

    eISSN： 1883-423X

    More details Close

    医薬品情報(DI)業務の方向性について、厚労省発行『患者のための薬局ビジョン』に記載された「対物業務から対人業務へ」の重要性を踏まえると、"患者情報に基づいたDI業務"が求められていると考えられる。地域医療の視点からみると、"患者情報に基づいたDI業務"が実践されれば、患者が医療施設等を移ってもDIが切れ目なく共有され、結果としてシームレスな薬物治療に寄与できると推測される。そこで今回、"患者情報に基づいたDI業務"および"地域でのシームレスな薬物治療に寄与するDI業務"という考え方に基づき、病院薬剤師と薬局薬剤師におけるDI業務の現状ならびに薬剤師が学びたいニーズについて調査するとともに、DIの薬薬連携を意図した研修会を企画・開催し、研修会終了後に参加者アンケートを行った。その結果、薬剤師のDI業務実践ならびに研究能力の向上を目指すうえで、薬剤師業務経験年数や研究発表経験の有無にかかわらず学会・学術会議などに参加してみることが重要と考えられた。また、今回の研修会のなかで実施した「薬薬連携に関する事例報告会」は、薬剤師の日常業務の参考になり、さらに自己研鑚の重要性を認識するきっかけにも成り得ると考えられた。

  417. Comparative Study of Pharmacists’ Perceptions of Clinical Literature Accessibility between Japan and USA– A Questionnaire Survey between Miyagi Prefecture and State of Florida – Peer-reviewed

    Nakagawa Naoto, Murai Yuriko, Obara Taku, Ohara Hiroshi, Kurita Sachiyo, Lai Leanne

    Iyakuhin Johogaku　19　(4)　180-187　2018

    Publisher: Japanese Society of Drug Informatics

    DOI： 10.11256/jjdi.19.180 　

    ISSN： 1345-1464

    eISSN： 1883-423X

    More details Close

    Objective: The clinical literature review is an important and required components in most of the US pharmacy school curriculum.  On the other hand, in Japan, pharmacy students usually read basic literature when research assignments are given.  However, in Japan, one is rarely taught how to critically read clinical literature in class.  Therefore, for the purpose of examining whether or not lectures regarding how to critically read clinical literature will affect collecting new drug information in pharmacy practice, we examined a survey which we circulated in both countries.  The survey asks pharmacists about reading clinical literature.<br>Methods: One thousand nine hundred and ninety-seven pharmacists in Miyagi in Japan were given questionnaires by mail and 18,744 pharmacists in Florida in the US were given the URL of a web questionnaire by email.<br>Results: Response rates in Miyagi and Florida were 30.3% and 0.91%, respectively.  Since the response in Florida was so small, statistical analysis was not performed.  Regarding the question of “Do you HABITUALLY read clinical literature ?,” “Yes” in Miyagi and Florida was 14.7% and 71.9%, respectively.  Regarding the question of “To what extent did you learn how to critically read clinical literature when you were a student-pharmacist ? ” (1: Not at all, 7: Yes), medians in Miyagi and Florida were “1” and “5,” respectively.  Regarding the question of “To what extent do you apply the information you obtain from clinical literature to your daily responsibilities ? ” (1: Not at all, 7: Yes), medians in Miyagi and Florida were “2” and “5,” respectively.<br>Conclusions: We conclude that Japanese pharmacists in clinical practice do not sufficiently utilize drug information from new clinical literature because pharmacy education in Japan did not, until very recently at least, teach how to critically read clinical literature in class.

  418. レセプトデータベースに基づく妊娠前，妊娠中，および出産後の抗てんかん薬処方状況の評価 Peer-reviewed

    石川 智史, 栗山 進一, 眞野 成康, 小原 拓, 神 一敬, 西郡 秀和, 都田 桂子, 鈴鹿 雅人, 赤沢 学, 中里 信和, 八重樫 伸生

    薬剤疫学　23　(0)　s98-s98　2018

    Publisher: 一般社団法人 日本薬剤疫学会

    DOI： 10.3820/jjpe.23.s98 　

    ISSN： 1342-0445

  419. Genome-wide association study for white coat effect in Japanese middle-aged to elderly people: The HOMED-BP study. International-journal Peer-reviewed

    Soshiro Ogata, Kei Kamide, Kei Asayama, Yasuharu Tabara, Takahisa Kawaguchi, Michihiro Satoh, Tomohiro Katsuya, Ken Sugimoto, Takuo Hirose, Ryusuke Inoue, Azusa Hara, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Fumihiko Matsuda, Jan A Staessen, Takayoshi Ohkubo, Hiromi Rakugi, Yutaka Imai

    Clinical and experimental hypertension (New York, N.Y. : 1993)　40　(4)　363-369　2018

    DOI： 10.1080/10641963.2017.1384481 　

    ISSN： 1064-1963

    More details Close

    BACKGROUND: White coat effect (WCE), the blood pressure (BP) difference between clinical and non-clinical settings, can lead to clinical problems such as misdiagnosis of hypertension. Etiology of WCE has been still unclear, especially from genetic aspects. The present article investigated association between genome-wide single nucleotide polymorphisms (SNPs) and WCE in patients with essential hypertension. METHODS: The present cross-sectional analyses were based on 295 Japanese essential hypertensive outpatients aged ≧40 years enrolled in randomized control study, Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study, who were not taking antihypertensive medications before the randomization. Home and clinic BP were measured. WCE was defined by subtracting home BP from clinic BP. Genotyping was conducted with 500K DNA microarray chips. Association between genome-wide SNPs and WCE were analyzed. For replication (p < 10-4), we analyzed participants from Ohasama study who took no antihypertension medications and whose SNPs were collected. RESULTS: Genome-wide SNPs were not significantly associated with WCE of systolic and diastolic BP after corrections of multiple comparisons (p < 2 × 10-7). We found suggestive SNPs associated with WCE of systolic and diastolic BP (p < 10-4). However, the consistent results were not obtained in the replication study. CONCLUSION: The present article showed no significant association between genome-wide SNPs and WCE. Since there were several suggestive SNPs associated with WCE, the present study warrants a further study with bigger sample size for investigating the genetic influence on WCE.

  420. Nocturnal blood pressure decline based on different time intervals and long-term cardiovascular risk: the Ohasama Study. International-journal Peer-reviewed

    Michihiro Satoh, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Megumi Tsubota-Utsugi, Taku Obara, Keiko Murakami, Ayako Matsuda, Takahisa Murakami, Kyoko Nomura, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo

    Clinical and experimental hypertension (New York, N.Y. : 1993)　40　(1)　1-7　2018

    DOI： 10.1080/10641963.2016.1259324 　

    ISSN： 1064-1963

    More details Close

    A diminished nocturnal decline in blood pressure (BP) represents a risk factor for cardiovascular disease. To define daytime and nighttime ambulatory BP, clock time-dependent methods are used when information on diary-based sleeping time is unavailable. We aimed to compare fixed-clock intervals with diary records to identify nocturnal BP declines as a predictor of long-term cardiovascular risk among the general population. Data were obtained from 1714 participants with no history of cardiovascular disease in Ohasama, Japan (mean age, 60.6 years; 64.9% women). We defined extreme dippers, dippers, non-dippers, and risers as nocturnal systolic BP decline ≥20%, 10-19%. 0-9%, and <0%, respectively. Over a mean follow-up period of 17.0 years, 206 cardiovascular deaths occurred. Based on diary records, multivariable-adjusted hazard ratios (HRs) for cardiovascular death compared with dippers were 1.24 (95% confidence interval [CI], 0.82-1.87) in extreme dippers, 1.21 (0.87-1.69) in non-dippers, and the highest HR of 2.31 (1.47-3.62) was observed in risers. Using a standard fixed-clock interval (daytime 09:00-21:00; nighttime 01:00-06:00), a nighttime 2 h-early shifted fixed-clock (daytime 09:00-21:00; nighttime 23:00-04:00), or a nighttime 2 h-late shifted fixed-clock (daytime 09:00-21:00; nighttime 03:00-08:00), the HR (95%CI) in risers compared with dippers was 1.57 (1.08-2.27), 2.02 (1.33-3.05), or 1.29 (0.86-1.92), respectively. Although use of diary records remains preferable, the standard and nighttime 2 h-early shifted fixed-clock intervals appear feasible for population-based studies.

  421. Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis Peer-reviewed

    Hiroshi Hidaka, Daiki Ozawa, Shinichi Kuriyama, Taku Obara, Toru Nakano, Risako Kakuta, Kazuhiro Nomura, Kenichi Watanabe, Yukio Katori

    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(11)　3951-3958　2017/11

    DOI： 10.1007/s00405-017-4716-3 　

    ISSN： 0937-4477

    eISSN： 1434-4726

  422. Exploring Risk Factors of Patient Falls: A Retrospective Hospital Record Study in Japan Peer-reviewed

    Mami Ishikuro, Sergio Ramon Gutierrez Ubeda, Taku Obara, Toshihide Saga, Naofumi Tanaka, Chiyo Oikawa, Keisei Fujimori

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　243　(3)　195-203　2017/11

    DOI： 10.1620/tjem.243.195 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  423. 家庭血圧および家庭脈拍とそれらの日間変動の加齢に伴う推移 大迫研究 Peer-reviewed

    佐藤 倫広, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 小原 拓, 村上 慶子, 村上 任尚, 原 梓, 川崎 良, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　40回　409-409　2017/10

    Publisher: (NPO)日本高血圧学会

  424. 降圧治療中患者におけるHome Arterial Stiffness Index(HASI)の臨床的有用性の評価 Peer-reviewed

    小原 拓, 菊谷 昌浩, 佐藤 倫広, 井上 隆輔, 浅山 敬, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　40回　446-446　2017/10

    Publisher: (NPO)日本高血圧学会

  425. Alterations in physique among young children after the Great East Japan Earthquake: Results from a nationwide survey Peer-reviewed

    Masahiro Kikuya, Hiroko Matsubara, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Shigeo Kure, Shinichi Kuriyama

    JOURNAL OF EPIDEMIOLOGY　27　(10)　462-468　2017/10

    DOI： 10.1016/j.je.2016.09.012 　

    ISSN： 0917-5040

  426. 一般地域住民における家庭血圧に基づく高血圧の分布 大迫研究 Peer-reviewed

    佐藤 倫広, 村上 任尚, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 坪田 恵, 小原 拓, 村上 慶子, 松田 彩子, 原 梓, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    東北公衆衛生学会誌　(66)　40-40　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  427. Pregnant Women's Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children's Study Peer-reviewed

    Hidekazu Nishigori, Toshie Nishigori, Kasumi Sakurai, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Zen Watanabe, Noriyuki Iwama, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Shinichi Kuriyama, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Fumiaki Takahashi, Nobuo Yaegashi

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(3)　355-364　2017/06

    DOI： 10.1017/dmp.2016.150 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  428. Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Satoshi Mizuno, Hirohito Metoki, Tetsuro Hoshiai, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    CONGENITAL ANOMALIES　57　(3)　72-78　2017/05

    DOI： 10.1111/cga.12202 　

    ISSN： 0914-3505

    eISSN： 1741-4520

  429. Drug Use before and during Pregnancy in Japan: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Satoshi Mizuno, Kasumi Sakurai, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Shinichi Kuriyama, Nobuo Yaegashi

    Pharmacy (Basel, Switzerland)　5　(2)　2017/04/10

    DOI： 10.3390/pharmacy5020021 　

    More details Close

    Purpose: To elucidate drug use before and during pregnancy in Japan. Methods: The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study. We analyzed data from JECS involving cases where drugs were used for 12 months before pregnancy was diagnosed, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy. Results: We analyzed data from 97,464 pregnant women. The percentages of pregnant women who had taken one or more drugs and supplements before diagnosis of pregnancy, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy, were 78.4%, 57.1%, and 68.8% respectively. Excluding iron supplements, folic acid, and other vitamins and minerals, the percentages of women taking supplements were 75.3%, 36.0%, and 51.7% at each respective time point. The following drugs and supplements were frequently used for 12 months before pregnancy diagnosis: Commercially available antipyretics, analgesics, and/or medicine for treating common cold (34.7%), antipyretics, analgesics, and/or medicine for treating common colds, which were prescribed in hospitals (29.8%), antimicrobial drugs (14.0%), and anti-allergy drugs (12.5%). The following drugs and supplements were frequently used from the time of pregnancy diagnosis until week 12 of pregnancy, and after week 12 of pregnancy: folic acid (28.9% and 26.2%), antipyretics, analgesics and/or medicines for treating common cold, that were prescribed in hospitals (7.8% and 13.3%), Chinese herbal medicines (6.0% and 9.4%, and uterine relaxants (5.1% and 15.2%). Conclusions: The analysis of a nationwide cohort study showed that a high percentage of Japanese pregnant women were taking medicinal drugs. Further research is required to elucidate the relationship between drug use during pregnancy and birth defects in Japan.

  430. Incidence of Domestic Violence Against Pregnant Females After the Great East Japan Earthquake in Miyagi Prefecture: The Japan Environment and Children's Study Peer-reviewed

    Kasumi Sakurai, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Fumiaki Takahashi, Kunihiko Nakai, Nobuo Yaegashi

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(2)　216-226　2017/04

    DOI： 10.1017/dmp.2016.109 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  431. 東日本大震災後の保育所園児における過体重の発症 被災地の子どもの発育状況等に関する全国調査 Peer-reviewed

    菊谷 昌浩, 松原 博子, 石黒 真美, 佐藤 ゆき, 小原 拓, 目時 弘仁, 磯島 豪, 横谷 進, 加藤 則子, 田中 敏章, 千田 勝一, 小野 敦史, 細矢 光亮, 横道 洋司, 山縣 然太朗, 田中 総一郎, 呉 繁夫, 栗山 進一

    宮城県公衆衛生学会会誌　(49)　15-15　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  432. Seasonal variation in self-measured home blood pressure among patients on antihypertensive medications: HOMED-BP study Peer-reviewed

    Tomohiro Hanazawa, Kei Asayama, Daisuke Watabe, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo

    HYPERTENSION RESEARCH　40　(3)　284-290　2017/03

    DOI： 10.1038/hr.2016.133 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  433. Prevalence and determinants of inadequate use of folic acid supplementation in Japanese pregnant women: the Japan Environment and Children's Study (JECS) Peer-reviewed

    Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE　30　(5)　588-593　2017/03

    DOI： 10.1080/14767058.2016.1179273 　

    ISSN： 1476-7058

    eISSN： 1476-4954

  434. Disease prevalence among nursery school children after the Great East Japan earthquake. International-journal Peer-reviewed

    Mami Ishikuro, Hiroko Matsubara, Masahiro Kikuya, Taku Obara, Yuki Sato, Hirohito Metoki, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Shigeo Kure, Shinichi Kuriyama

    BMJ global health　2　(2)　e000127　2017

    DOI： 10.1136/bmjgh-2016-000127 　

    More details Close

    OBJECTIVE: To investigate the relationship between personal experience of the Great East Japan Earthquake and various disease types among nursery school children. DESIGN: We conducted a nationwide survey of nursery school children born between 2 April 2006 and 1 April 2007. Nursery school teachers completed questionnaires if they agreed to join the study. Questionnaire items for children consisted of their birth year and month, sex, any history of moving into or out of the current nursery school, presence of diseases diagnosed by a physician at the age of 66-78 months and type of disaster experience. The survey was conducted from September 2012 to December 2012. SETTING: Japan, nationwide. PARTICIPANTS: A total of 60 270 nursery school children were included in the analysis, 840 of whom experienced the disaster on 11 March 2011. MAIN OUTCOME MEASURES: The health status of children 1.5 years after the disaster based on nursery school records. RESULTS: Experiencing the disaster significantly affected the prevalence of overall and individual diseases. Furthermore, there was a difference in disease prevalence between boys and girls. In boys, experiencing the tsunami (OR 2.53, 95% CI 1.22 to 5.24) and living in an evacuation centre (OR 2.92, 95% CI 1.46 to 5.83) were remarkably associated with a higher prevalence of atopic dermatitis, but these trends were not observed among girls. Instead, the home being destroyed (OR 3.50, 95% CI 2.02 to 6.07) and moving house (OR 4.19, 95% CI 2.01 to 8.71) were positively associated with a higher prevalence of asthma among girls. CONCLUSIONS: Our study indicates that experiencing the disaster may have affected the health status of nursery school children at least up to 1.5 years after the disaster. Continuous monitoring of the health status of children is necessary to develop strategic plans for child health.

  435. Randomized controlled trial of the effects of consumption of 'Yabukita' or 'Benifuuki' encapsulated tea-powder on low-density lipoprotein cholesterol level and body weight. International-journal Peer-reviewed

    Yuko Igarashi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Michiko Shigihara, Hirohito Metoki, Masahiro Kikuya, Yoichi Sameshima, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

    Food & nutrition research　61　(1)　1334484-1334484　2017

    DOI： 10.1080/16546628.2017.1334484 　

    More details Close

    Background: Previous studies have reported controversial results for the association between green tea consumption and low-density lipoprotein (LDL)-cholesterol and body weight. Objective: The objective of this trial was to determine the effects of two kinds of green tea on LDL-cholesterol and body weight. Methods: We randomly assigned 151 participants (98 men, 53 women) aged 30-70 years into three groups: Yabukita green tea group, Benifuuki green tea group, or placebo group. Participants consumed 1.8 g/day of green tea extract powder or placebo for 12 weeks. The primary outcomes were LDL-cholesterol level and body weight, and the secondary outcomes were risk factors for cardiovascular disease. Results: Both Yabukita and Benifuuki green tea significantly lowered LDL-cholesterol. The magnitudes of the lipid-lowering effect of both types of tea were significantly larger than that of placebo. No differences with respect to changes in LDL-cholesterol were observed between the Yabukita and Benifuuki green tea groups. Neither Yabukita nor Benifuuki green tea had any effect on body weight and no difference was observed among groups regarding changes in body weight. Conclusion: Both Yabukita and Benifuuki green tea lowered LDL-cholesterol, and the lipid-lowering effects of these two green teas were not different. Neither tea lowered body weight.

  436. Trends in Antihypertensive Drug Prescriptions Based on Claims Data in a Japanese Hospital

    Satoh Michihiro, Kurosawa Keiko, Obara Taku, Matsuura Masaki, Inoue Ryusuke, Takahashi Nobuyuki, Sato Hiroshi, Murai Yuriko, Mano Nariyasu

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)　43　(1)　9-17　2017

    Publisher: 一般社団法人日本医療薬学会

    ISSN： 1346-342X

    eISSN： 1882-1499

    More details Close

    &lt;p&gt;Details regarding trends in the prescription rates of antihypertensive drugs after 2011 are unclear. Therefore, we compared the prescription rates of antihypertensive drugs in 2009 with those in 2014 using claim records. Data were extracted from claims data provided from April-July 2009 and from April-July 2014 in Tohoku University Hospital, Sendai, Japan. Prescription rates were presented as the percentage of patients who were prescribed each drug. We compared the prescription rates in 2009 (n = 3,954, mean age 63.8 years, men 53.4％) with those in 2014 (n = 5,196, mean age 63.3 years, men 52.9％). The two most prescribed classes of antihypertensive drugs were angiotensin II receptor blockers and calcium channel blockers in both years (≥ 60％). No significant changes in the prescription rates for these two classes were observed between 2009 and 2014. The prescription rate for aldosterone blockers and αβ-blockers increased from 12.6％ and 8.4％ in 2009 to 16.9％ and 13.5％ in 2014 (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001), respectively. In contrast, the prescription rate for angiotensin converting enzyme inhibitors and α-blockers decreased from 23.5％ and 10.4％ in 2009 to 15.6％ and 7.7％ in 2014 (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001), respectively. The prescription rates for thiazide diuretics, non-thiazide diuretics other than aldosterone blockers, β-blockers, and other classes of antihypertensive did not differ significantly between 2009 and 2014. The prescription rates of antihypertensive drugs have changed based on new evidence regarding the drugs&#039; mechanisms of action on hypertension or their adverse effects.&lt;/p&gt;

  437. Fermented food consumption and psychological distress in pregnant women: A nationwide birth cohort study of the Japan environment and children’s study Peer-reviewed

    Fumiaki Takahashi, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Mami Ishikuro, Noriyuki Iwama, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi, Hirohisa Saito, Reiko Kishi, Koichi Hashimoto, Chisato Mori, Fumiki Hirahara, Zentaro Yamagata, Hidekuni Inadera, Michihiro Kamijima, Ikuo Konishi, Hiroyasu Iso, Masayuki Shima, Toshihide Ogawa, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh

    Tohoku Journal of Experimental Medicine　240　(4)　309-321　2016/12/01

    DOI： 10.1620/tjem.240.309 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  438. Prescription trends in children with pervasive developmental disorders: a claims data-based study in Japan. International-journal Peer-reviewed

    Michihiro Satoh, Taku Obara, Hidekazu Nishigori, Nobuhiro Ooba, Yoshihiko Morikawa, Mami Ishikuro, Hirohito Metoki, Masahiro Kikuya, Nariyasu Mano

    World journal of pediatrics : WJP　12　(4)　443-449　2016/11

    DOI： 10.1007/s12519-016-0036-8 　

    ISSN： 1708-8569

    eISSN： 1867-0687

    More details Close

    BACKGROUND: The only drug approved for pervasive developmental disorders (PDD) in Japan is pimozide. Several psychotropic drugs are also prescribed for offlabel use in Japan, but details regarding their prescription and use are largely unknown. The purpose of this study was to clarify the use of drug treatment in Japanese children with PDD. METHODS: Data were extracted from claims data from the Japan Medical Data Center for children younger than 18 years of age who were newly diagnosed with PDD (International Classification of Diseases version 10 codes: F84) from 2005 to 2010 (total of 3276 patients as of 2010). The prescription rates were presented as the percentage of PDD patients who were prescribed each drug. RESULTS: Prior to 2010, the prescription rates for atypical antipsychotics, other antipsychotics, psychostimulants, all other central nervous system drugs, anticovnvulsants, non-barbiturates, and Parkinson's disease/syndrome drugs significantly increased among the Anatomical Therapeutic Chemical classifications defined as the "nervous system" (trend P≤0.02). The prescription rate for risperidone consistently increased, reaching 6.9% in 2010 (trend P<0.0001), the highest rate of the surveyed drugs among the antipsychotics. The prescription rate for aripiprazole also increased (trend P<0.0001), reaching 1.9% in 2010. The prescription rate for pimozide showed no annual changes, with a low rate of 0.4% in 2010. CONCLUSION: Compared with pimozide, the prescription rates for risperidone, aripiprazole and other psychotropic drugs have increased. Because safety data for these drugs in Japanese children are sparse, there is a need for future safety evaluations of these drugs in Japanese children.

  439. Present Condition of Fall Incidents in Tohoku University Hospital, Japan Peer-reviewed

    Harumi Memezawa, Chiyo Oikawa, Masao Tabata, Taku Obara, Keisei Fujimori

    ISQua’s 34rd International Conference　2016/10/16

  440. Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study Peer-reviewed

    Satoshi Mizuno, Hidekazu Nishigori, Takashi Sugiyama, Fumiaki Takahashi, Noriyuki Iwama, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Kunihiko Nakai, Hidekuni Inadera, Nobuo Yaegashi

    DIABETES RESEARCH AND CLINICAL PRACTICE　120　132-141　2016/10

    DOI： 10.1016/j.diabres.2016.07.020 　

    ISSN： 0168-8227

    eISSN： 1872-8227

  441. 出生児の神経管閉鎖障害リスク低下を目的とした葉酸摂取に関する地域の薬剤師の認識と推奨の割合と要因

    浅野 二未也, 小原 拓, 佐藤 倫広, 大原 宏司, 山口 浩明, 早坂 正孝, 眞野 成康, 村井 ユリ子

    医薬品相互作用研究　40　(1-2)　14-20　2016/09

    Publisher: (一社)医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    出生時の神経管閉鎖障害リスク低下を目的とした妊婦の葉酸摂取に関する地域の薬剤師の認識などを明らかにすることを目的に、札幌市および福島県の薬剤師会に所属する薬剤師を対象に質問紙調査を行い、787名より有効回答を得た。その結果、厚生労働省が推奨している出生時の神経管閉鎖障害リスクを低下させるのに最も適切な1日の葉酸摂取量に対する薬剤師の認識は、葉酸摂取開始時期(妊娠前。400μg/日)が52.9%、妊娠中(400μg/日)が49.8%、授乳中(300μg/日)が38.5%で、先行研究と比較してとくに妊娠中・授乳中の1日葉酸摂取量の認識が高く、これは回答者における出産歴のある女性の割合が先行研究よりも高かったことによるものと考えられた。

  442. わが国の外来患者における家庭血圧測定の現状 10年の変遷

    小原 拓, 阿部 真也, 吉町 昌子, 佐藤 倫広, 大久保 孝義, 眞野 成康, 後藤 輝明, 今井 潤

    日本高血圧学会総会プログラム・抄録集　39回　426-426　2016/09

    Publisher: (NPO)日本高血圧学会

  443. 一般地域住民における異なる時間定義に基づく夜間降圧度と脳心血管長期予後との関連 大迫研究 Peer-reviewed

    佐藤 倫広, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 坪田 恵, 小原 拓, 村上 慶子, 松田 彩子, 村上 任尚, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　39回　319-319　2016/09

    Publisher: (NPO)日本高血圧学会

  444. 家庭血圧の季節変動と脳心血管イベントとの関連 HOMED-BP研究 Peer-reviewed

    花澤 智大, 浅山 敬, 渡部 大介, 田辺 杏由美, 佐藤 倫広, 井上 隆輔, 小原 拓, 菊谷 昌浩, 野村 恭子, 目時 弘仁, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　39回　387-387　2016/09

    Publisher: (NPO)日本高血圧学会

  445. The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements Peer-reviewed

    Michihiro Satoh, Toshikazu Haga, Miki Hosaka, Taku Obara, Hirohito Metoki, Takahisa Murakami, Masahiro Kikuya, Ryusuke Inoue, Kei Asayama, Nariyasu Mano, Takayoshi Ohkubo, Yutaka Imai

    JOURNAL OF HYPERTENSION　34　(6)　1218-1223　2016/06

    DOI： 10.1097/HJH.0000000000000902 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  446. Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area Peer-reviewed

    Mami Ishikuro, Naoki Nakaya, Taku Obara, Yuki Sato, Hirohito Metoki, Masahiro Kikuya, Naho Tsuchiya, Tomohiro Nakamura, Fuji Nagami, Shinichi Kuriyama, Atsushi Hozawa

    PREHOSPITAL AND DISASTER MEDICINE　31　(3)　330-334　2016/06

    DOI： 10.1017/S1049023X16000182 　

    ISSN： 1049-023X

    eISSN： 1945-1938

  447. Knowledge, Attitude, and Practices Toward Blood Pressure Measurement at Home Among Japanese Nurses. International-journal Peer-reviewed

    Ishikuro M, Ubeda SR, Obara T, Watanabe I, Metoki H, Kikuya M, Kuriyama S, Maruyama R, Ohkubo T, Imai Y

    Home healthcare now　34　(4)　210-217　2016/04

    DOI： 10.1097/NHH.0000000000000357 　

    ISSN： 2374-4529

    More details Close

    The self-measurement of blood pressure (BP) at home is useful in predicting the level of target organ damage and in managing hypertension. Nurses are essential practitioners for managing hypertension; however, it is unclear whether they have adequate knowledge of home BP management. This study assessed the knowledge, attitudes, and practices of home BP measurement among Japanese nurses. A questionnaire regarding home BP measurement was distributed among nurses and collected by mail. A total of 6,002 (61.8%) responses were eligible for the study. The proportion of participants who correctly recognized the reference values for clinic BP and home BP was 9.9% and 2.8%. Midwives and those working for the government had the highest proportion of correct responses of reference values among all nursing subgroups. Participants who thought that home BP gave the most important BP information were 62.7%. About 60% of the participants who recommended home BP measurement to hypertensive patients preferred to recommend an upper-arm cuff device. Our findings suggested that more knowledge of home BP measurement among nurses is warranted.

  448. 本邦の薬剤師におけるファーマコビジランスに関する認識と展望

    小原 拓, 吉田 真貴子, 山口 浩明, 赤坂 和俊, 松浦 正樹, 佐藤 真由美, 村井 ユリ子, 土屋 文人, 北田 光一, 眞野 成康

    日本薬学会年会要旨集　136年会　(4)　229-229　2016/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  449. 三世代コホート調査の進捗について Peer-reviewed

    目時 弘仁, 石黒 真美, 小原 拓, 佐藤 ゆき, 菊谷 昌浩, 栗山 進一, 寳澤 篤, 大隅 典子, 清元 秀泰, 菅原 準一, 鈴木 洋一, 冨永 悌二, 布施 昇男, 峯岸 直子, 辻 一郎, 呉 繁夫, 八重樫 伸生, 山本 雅之

    宮城県公衆衛生学会会誌　(48)　10-10　2016/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  450. Pregnant Women Had the Risk of Psychological Distress in Miyagi After the Great East Japan Earthquake: The Japan Environment and Children's Study (JECS). Peer-reviewed

    Zen Watanabe, Hirohito Metoki, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES　23　186A-186A　2016/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  451. Knowledge of and perspectives on pharmacovigilance among pharmacists in the Miyagi and Hokkaido regions of Japan Peer-reviewed

    Taku Obara, Hiroaki Yamaguchi, Yutaro Iida, Michihiro Satoh, Takamasa Sakai, Yoshiko Aoki, Yuriko Murai, Masaki Matsuura, Mayumi Sato, Takayoshi Ohkubo, Ken Iseki, Nariyasu

    J Pharmacovigil　4　(1)　192　2016/02

    DOI： 10.4172/2329-6887.1000192 　

  452. Home blood pressure level and decline in renal function among treated hypertensive patients: the J-HOME-Morning Study Peer-reviewed

    Kazuki Ishikura, Taku Obara, Masahiro Kikuya, Michihiro Satoh, Miki Hosaka, Hirohito Metoki, Hidekazu Nishigori, Nariyasu Mano, Masaaki Nakayama, Yutaka Imai, Takayoshi Ohkubo

    HYPERTENSION RESEARCH　39　(2)　107-112　2016/02

    DOI： 10.1038/hr.2015.110 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  453. Awareness of Nursing Students about the Importance of Folic Acid Intake for the Prevention of Neural Tube Defects

    ONOGI Hiroshi, OBARA Taku, ASANO Fumiya, SATOH Michihiro, MANO Nariyasu, SATOH Kineko, MURAI Yuriko

    Japanese Journal of Complementary and Alternative Medicine　13　(1)　7-11　2016

    Publisher: The Japanese Society for Complementary and Alternative Medicine

    DOI： 10.1625/jcam.13.7 　

    ISSN： 1348-7922

    More details Close

    Objective: Adequate periconceptional intake of folic acid decreases the risk of neural tube defects of infant. The present study aimed to investigate the awareness of nursing students about the importance of folic acid intake for the prevention of neural tube defects.Design: Questionnaire survey.Methods: A self-administered questionnaire regarding the importance of folic acid intake for the prevention of neural tube defects was distributed to 423 nursing students of Tohoku University and Tohoku Fukushi University.Results: Among the 408 respondents (response rate; 96.5%), 129 (31.6%) nursing students were aware that folic acid intake decreases the risk of neural tube defects. In the multivariate logistic regression analysis, grade 3-4 (odds ratio = 11.779, 95% confident interval = 5.739-24.177) were associated with the awareness of the importance of folic acid intake among nursing students. Of 129 nursing students who recognized the importance of folic acid intake, 52 (40.3%) and 11 (8.5%) recognized that women should begin folic acid intake before conception and should take about 400μg of folic acid per day during pregnancy respectively.Conclusion: About 30% of nursing students recognized that folic acid intake decreases the risk of neural tube defects and many did not know the details of the effective intake for the prevention of neural tube defects. Therefore, more aggressive promotion of the awareness of the importance of folic acid intake among nursing students is warranted.

  454. Awareness of Pharmacy Students regarding the Importance of Folic Acid Intake for the Prevention of Neural Tube Defects

    Takahashi Atsushi, Obara Taku, Ohara Hiroshi, Satoh Michihiro, Asano Fumiya, Onogi Hiroshi, Hayasaka Masataka, Satoh Hiroshi, Mano Nariyasu, Murai Yuriko

    Iyakuhin Johogaku　17　(4)　185-191　2016

    Publisher: Japanese Society of Drug Informatics

    DOI： 10.11256/jjdi.17.185 　

    ISSN： 1345-1464

    More details Close

    Objective: Adequate periconceptional folic acid intake decreases the risk of neural tube defects in infants.  The present study aimed to investigate the awareness of pharmacy students regarding the importance of folic acid intake for the prevention of neural tube defects.Design: Questionnaire survey.Methods: A self-administered questionnaire regarding the importance of folic acid intake for the prevention of neural tube defects was distributed to 750 pharmacy students at Tohoku and Ohu Universities.Results: Among the 685 respondents (response rate; 91.3%), 74 (10.8%) were aware that folic acid intake decreases the risk of neural tube defects.  In multivariate logistic regression analysis, awareness of the importance of folic acid intake was evident among 5th- and 6th-year pharmacy students (odds ratio=3.352, 95% confidence interval=1.797-6.253) and among those who used dietary supplements (2.275, 1.306-3.966).  Among the 74 pharmacy students who recognized the importance of folic acid intake, 17 (23.0%) and 3 (4.1%) were aware that women should begin taking a folic acid supplement before conception and should take about 400 μg per day during pregnancy, respectively.Conclusion: Only about 10% of the pharmacy students in this study recognized that folic acid intake decreases the risk of neural tube defects, and many were unaware of the recommended intake amount.  Therefore, awareness of the importance of folic acid intake must be more aggressively promoted among pharmacy students.

  455. Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements The Ohasama Study Peer-reviewed

    Michihiro Satoh, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Miki Hosaka, Megumi Tsubota-Utsugi, Taku Obara, Aya Ishiguro, Keiko Murakami, Ayako Matsuda, Daisaku Yasui, Takahisa Murakami, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

    HYPERTENSION　67　(1)　48-55　2016/01

    DOI： 10.1161/HYPERTENSIONAHA.115.06461 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  456. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study Peer-reviewed

    Zen Watanabe, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi

    JOURNAL OF AFFECTIVE DISORDERS　190　341-348　2016/01

    DOI： 10.1016/j.jad.2015.10.024 　

    ISSN： 0165-0327

    eISSN： 1573-2517

  457. ドラッグストア併設型薬局勤務薬剤師における家庭血圧測定に関する認識と実践

    山口 浩, 小原 拓, 佐藤 倫広, 阿部 真也, 吉町 昌子, 今井 潤, 後藤 輝明

    医薬品相互作用研究　39　(2)　83-90　2015/12

    Publisher: (一社)医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    ドラッグストア併設型薬局勤務薬剤師における家庭血圧測定に関する認識と実践について検討した。調剤専門薬局に勤務する薬剤師92例、ドラッグストア併設型薬局に勤務する薬剤師192例を対象とした。77.1%が家庭血圧は外来血圧よりも重要と回答し、71.8%が降圧薬服用中の患者に家庭血圧測定を推奨した。71.6〜78.8%が上腕型血圧計の使用を推奨した。推奨する家庭血圧測定のタイミングは、朝が80.6〜87.7%、夜が57.7〜58.2%であった。日本高血圧学会「高血圧治療ガイドライン」は31.3%、「家庭血圧測定の指針」は13.7%が知っていた。外来血圧に基づく高血圧基準値および家庭血圧に基づく高血圧基準値を正確に認識していた割合は、調剤専門薬局勤務薬剤師に比べ、ドラッグストア併設型薬局勤務薬剤師の方が高い傾向を認めた。家庭血圧の収縮期血圧および拡張期血圧の両方で無回答の割合が最も高かった。

  458. 医薬品リスク管理計画に関する医薬情報担当者の認識 Peer-reviewed

    菊池 大輔, 小原 拓, 石井 隆, 大内 竜介, 三浦 良祐, 山田 尚之, 畑中 貞雄

    医薬品相互作用研究　39　(2)　91-94　2015/12

    Publisher: 医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    医薬品リスク管理計画(RMP)に関する医薬情報担当者(MR)の認識について検討した。製薬会社MR 72名(72社)を対象とした。MR経験年数が10年以上は48.6%、医薬品医療機器総合機構(PMDA)のメディナビへの登録は43.1%、PMDAホームページへRMPが掲載されていることを知っているのは48.6%、所属先でRMP該当薬の取り扱いがあるのは37.5%で、RMPを理解しているのは12.5%、理解していないのは87.5%であった。RMPを理解している割合と所属先のMR総数との間に有意差を認めたが、一定の傾向は認めなかった。所属先でRMP該当薬の取り扱いやRMPに関するセミナー等があったとしても、RMPを理解している割合は20%であった。所属先でRMP該当薬の取り扱いやRMPセミナー等がある群で、PMDAホームパージへRMPが掲載されていることの認識率が有意に高値で、PMDAのメディナビへ登録している割合は比較的高値であった。

  459. 本態性高血圧患者における未治療時および降圧治療中の家庭血圧指標(収縮期、拡張期、平均、脈圧)の脳心血管イベント予測能 HOMED-BP研究 Peer-reviewed

    渡部 大介, 浅山 敬, 花澤 智大, 安井 大策, 井上 隆輔, 保坂 実樹, 佐藤 倫広, 小原 拓, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　38回　396-396　2015/10

    Publisher: (NPO)日本高血圧学会

  460. 家庭血圧に基づくアジルサルタンの臨床的評価 Peer-reviewed

    芳賀 俊和, 佐藤 倫広, 保坂 実樹, 渡部 大介, 小原 拓, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 眞野 成康, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　38回　397-397　2015/10

    Publisher: (NPO)日本高血圧学会

  461. 不妊症既往と妊娠中の血圧との関連 Peer-reviewed

    石黒 真美, 小原 拓, 目時 弘仁, 菊谷 昌浩, 栗山 進一, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　38回　406-406　2015/10

    Publisher: (NPO)日本高血圧学会

  462. 新生児血圧に影響する要因の検討 BOSHI-新生児研究 Peer-reviewed

    井上 隆輔, 目時 弘仁, 大久保 孝義, 小原 拓, 菊谷 昌浩, 佐藤 倫広, 保坂 実樹, 多田 秀子, 八木橋 香津代, 田中 耕平, 星 和彦, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　38回　406-406　2015/10

    Publisher: (NPO)日本高血圧学会

  463. Prevalence, determinants, and reasons for the non-reporting of adverse drug reactions by pharmacists in the Miyagi and Hokkaido Regions of Japan Peer-reviewed

    Taku Obara, Hiroaki Yamaguchi, Michihiro Satoh, Yutaro Iida, Takamasa Sakai, Yoshiko Aoki, Yuriko Murai, Masaki Matsuura, Mayumi Sato, Takayoshi Ohkubo, Ken Iseki, Nariyasu Mano

    Adv Pharmacoepidemiol Drug Saf　4　(5)　191　2015/09

    DOI： 10.4172/2167-1052.1000191 　

  464. 周産期における葉酸摂取の重要性に関する薬剤師の認識

    酒井 隆全, 小原 拓, 竹林 まゆみ, 水野 恵司, 杉浦 尚子, 竹内 一仁, 大津 史子, 瀬尾 智子, 種村 光代, 山崎 嘉久, 村井 ユリ子

    日本薬剤師会雑誌　67　(6)　803-807　2015/06

    Publisher: (公社)日本薬剤師会

    ISSN： 0369-674X

  465. Awareness of the Japanese Society of Hypertension Guidelines for the Management of Hypertension and their use in clinical practices: 2009 survey results. International-journal Peer-reviewed

    Taku Obara, Sergio Ramón Gutiérrez Ubeda, Takayoshi Ohkubo, Hideo Matsuura, Toshihiko Ishimitsu, Masanobu Takata, Hiromi Rakugi, Yutaka Imai

    Hypertension research : official journal of the Japanese Society of Hypertension　38　(6)　400-4　2015/06

    DOI： 10.1038/hr.2015.21 　

    ISSN： 0916-9636

    More details Close

    The objective of this study was to investigate physicians' awareness and use of the Japanese Society of Hypertension (JSH) Guidelines for the Management of Hypertension (JSH2004 and JSH2009), and determine what changes need to be implemented in the future. A questionnaire was used to survey physicians' awareness and their use of JSH2004 and JSH2009. Physicians attending educational seminars on hypertension that were held during the months after the publication of JSH2009 (January-April 2009) were asked to participate in the survey. Of the 5795 respondents, 88% were aware of the JSH2009 publication. Furthermore, physicians were also aware of JSH2004, with about 90% using JSH2004 in their practice. A hypertension blood pressure (BP) reference value of 140/90 mm Hg was used by 55% in office BP, whereas 31% used 135/85 mm Hg for home BP. Target BP levels used by physicians were 130/80 mm Hg for patients with diabetes or kidney disease (52%) and for elderly patients with diabetes or kidney disease (45%), whereas 140/90 mm Hg was used for elderly patients with low cardiovascular disease risk (44%) and for patients with chronic-phase stroke (27%). Answers to the questionnaire varied among physicians according to sex, age, workplace and specialty. The majority of the participating Japanese physicians were familiar with both JSH2004 and JSH2009, with many following the guidelines in their practice. However, some physicians use different reference values for hypertension and target BP levels. Physicians' adherence to and use of the guidelines should be regularly examined and promoted.

  466. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake Peer-reviewed

    Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　236　(2)　123-130　2015/06

    DOI： 10.1620/tjem.236.123 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  467. 高血圧患者におけるβ遮断薬の家庭心拍減少および降圧効果検証のための介入研究 J-HOE-HR研究

    新木 貴大, 小原 拓, 後ノ上 健太, 芝宮 拓, 佐藤 倫広, 眞野 成康, 今井 潤, 大久保 孝義, J-HOME-HR研究グループ

    Therapeutic Research　36　(5)　429-438　2015/05

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

    More details Close

    高血圧患者におけるβ遮断薬の家庭心拍減少および降圧効果検証のための介入研究を実施した。上腕式の家庭血圧計を用いて家庭血圧測定を継続中で、早朝家庭心拍が高値でかつ、早朝家庭血圧が管理不良で、降圧薬服用中の本態性高血圧症患者53例を対象とした。早朝家庭心拍、就寝前家庭心拍、外来心拍は、服用前に比較したところ、服用後有意に低下した。上室性期外収縮(PAC)および心室性期外収縮(PVC)においては、1000拍あたりの不整脈発生数に服用前後で有意差は認められなかった。アテノロール服用後に、R-R間隔およびHFに有意な上昇を認め、LF/HFに有意な低下が認められた。早朝家庭収縮期血圧は朝服用者に比較し、夕・就寝前で有意に低値であった。朝服用者および夕・就寝前服用者において、早朝・就寝前家庭心拍は服用後に有意に低下した。

  468. ドラッグストア併設型薬局薬剤師における周産期の葉酸摂取の重要性に関する認識

    阿部 真也, 小原 拓, 佐藤 倫広, 山口 浩, 吉町 昌子, 村井 ユリ子, 後藤 輝明

    医薬品相互作用研究　38　(3)　150-155　2015/05

    Publisher: (一社)医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    保健薬局薬剤師372名を対象に、周産期の葉酸摂取に関する知識について自記式質問票調査を行い、276名(74.2%)から回答を得た。対象を、「ドラッグストア併設型薬局薬剤師(ドラッグストア群)」186名と、「調剤専門型保健薬局薬剤師(調剤専門群)」90名に分けて比較した。ドラッグストア群では調剤専門群に比べ若年者、男性、妊婦への服薬指導頻度が高い薬剤師が有意に多かった。ドラッグストア群/調剤専門群の認識割合(%)では、葉酸の神経管閉鎖障害リスク低減効果:78.0/80.0、情報源はインターネット:27.6/29.2、一般雑誌:24.8/30.6、その他:27.6/23.6、その他で最多は社内試験であった。葉酸摂取の最適時期は妊娠前:33.1/47.2、妊婦の葉酸摂取量は400μg/日(推奨量440μg/日):24.1/33.3、授乳婦の葉酸摂取量は300μg/日(推奨量340μg/日):20.7/26.4、葉酸供給源は、「葉酸単独サプリメント」:65.5/61.1、妊娠可能期に葉酸摂取を推奨:24.8/23.6であった。

  469. Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake Peer-reviewed

    Jun Hasegawa, Hiroshi Hidaka, Shinichi Kuriyama, Taku Obara, Ken Hashimoto, Yutaka Tateda, Yuri Okumura, Toshimitsu Kobayashi, Yukio Katori

    PLOS ONE　10　(4)　2015/04

    DOI： 10.1371/journal.pone.0122631 　

    ISSN： 1932-6203

  470. レセプトデータを用いた東北大学病院の本態性高血圧患者における降圧薬の処方動向調査

    黒澤 桂子, 佐藤 倫広, 飯田 優太郎, 小原 拓, 松浦 正樹, 井上 隆輔, 高橋 信行, 佐藤 博, 村井 ユリ子, 眞野 成康

    日本薬学会年会要旨集　135年会　(4)　134-134　2015/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  471. Cup-shaped medication recording device for taking intraoral pictures Peer-reviewed

    Kenji Ishii, Yoko Kawai, Noriko Tsuruoka, Takahiro Fuse, Taku Obara, Tadao Matsunaga, Yutaka Imai, Yoichi Haga

    IEEJ Transactions on Electronics, Information and Systems　135　(2)　197-203　2015/02/01

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejeiss.135.197 　

    ISSN： 1348-8155 0385-4221

  472. Awareness regarding clinical application of pharmacogenetics among Japanese pharmacists Peer-reviewed

    Taku Obara, Taku Obara, Taku Obara, Shinya Abe, Michihiro Satoh, Sergio Ramón Gutiérrez Ubeda, Shoko Yoshimachi, Teruaki Goto

    Pharmacogenomics and Personalized Medicine　8　35-41　2015/01/29

    Publisher: Dove Medical Press Ltd

    DOI： 10.2147/PGPM.S71813 　

    ISSN： 1178-7066

  473. 一般地域住民におけるセルフメディケーションの実態とその要因に関する調査 大迫研究 Peer-reviewed

    佐藤 倫広, 松本 章裕, 原 梓, 岩森 紗希, 小原 拓, 菊谷 昌浩, 目時 弘仁, 保坂 実樹, 淺山 敬, 高橋 信行, 佐藤 博, 眞野 成康, 今井 潤, 大久保 孝義

    薬学雑誌　134　(12)　1347-1355　2014/12

    Publisher: (公社)日本薬学会

    ISSN： 0031-6903

    eISSN： 1347-5231

    More details Close

    一般地域住民におけるセルフメディケーションの実態とその要因について検討した。大迫町の一般地域住民1008例を対象とした。OTC・サプリメントの使用経験があったものは519例(51.5%)であった。使用したことのあるOTCとして、風邪薬、目薬、湿布が、サプリメントの健康食品や栄養ドリンクが高率に挙げられた。OTC・サプリメント使用経験がある者で、女性及び脂質異常症既往者が高率で、現在喫煙者が低率であった。家庭血圧は、OTC・サプリメント使用経験がある者で低値であった。OTC・サプリメント使用経験の規定因子として、女性、配置販売業者の訪問回数(年に2〜3回以上)、脂質異常症あり.及び家庭収縮期血圧低値が選択された。降圧薬服用量において、家庭血圧とOTC・サプリメント使用経験との間に負の関連を認めた。

  474. Surveys of postpartum depression in Miyagi, Japan, after the Great East Japan Earthquake Peer-reviewed

    Hidekazu Nishigori, Junichi Sugawara, Taku Obara, Toshie Nishigori, Kineko Sato, Takashi Sugiyama, Kunihiro Okamura, Nobuo Yaegashi

    ARCHIVES OF WOMENS MENTAL HEALTH　17　(6)　579-581　2014/12

    DOI： 10.1007/s00737-014-0459-y 　

    ISSN： 1434-1816

    eISSN： 1435-1102

  475. A Survey of Self-medication Practices and Related Factors in the General Population: the Ohasama Study Peer-reviewed

    Michihiro Satoh, Akihiro Matsumoto, Azusa Hara, Saki Iwamori, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Miki Hosaka, Kei Asayama, Nobuyuki Takahashi, Hiroshi Sato, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　134　(12)　1347-1355　2014/12

    ISSN： 0031-6903

  476. 妊婦における尿中塩分排泄量と塩分・栄養診断システム算出の塩分摂取量の相関 Peer-reviewed

    佐藤 倫広, 丹野 由美, 保坂 実樹, 目時 弘仁, 小原 拓, 淺山 敬, 眞野 成康, 星 和彦, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　37回　370-370　2014/10

    Publisher: (NPO)日本高血圧学会

  477. 本態性高血圧患者における家庭血圧と脳心血管疾患発症リスクの男女別解析 HOMED-BP研究 Peer-reviewed

    保坂 実樹, 浅山 敬, 佐藤 倫広, 井上 隆輔, 小原 拓, 目時 弘仁, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　37回　376-376　2014/10

    Publisher: (NPO)日本高血圧学会

  478. 抗精神病薬と高血糖・糖尿病発症の関連 レセプトデータに基づく検討

    佐藤 倫広, 小原 拓, 大場 延浩, 森川 和彦, 西郡 秀和, 眞野 成康

    日本医薬品情報学会総会・学術大会講演要旨集　17回　158-158　2014/07

    Publisher: (一社)日本医薬品情報学会

  479. Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline The Ohasama Study Peer-reviewed

    Akihiro Matsumoto, Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Mikio Hirano, Ryusuke Inoue, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Aya Hosokawa, Kazuhito Totsune, Haruhisa Hoshi, Toru Hosokawa, Hiroshi Sato, Yutaka Imai

    HYPERTENSION　63　(6)　1333-1338　2014/06

    DOI： 10.1161/HYPERTENSIONAHA.113.01819 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  480. 家庭血圧に基づく血漿アルドステロン濃度/血漿レニン活性比とNon-dippingの関連 大迫研究

    佐藤 倫広, 保坂 実樹, 菊谷 昌浩, 淺山 敬, 井上 隆輔, 坪田 恵, 原 梓, 廣瀬 卓男, 小原 拓, 目時 弘仁, 戸恒 和人, 星 晴久, 眞野 成康, 今井 潤, 大久保 孝義

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　3回　115-115　2014/05

    Publisher: (NPO)日本高血圧学会

  481. Consumption of fruits, vegetables, and seaweeds (sea vegetables) and pancreatic cancer risk: The Ohsaki Cohort Study Peer-reviewed

    Michiko Shigihara, Taku Obara, Masato Nagai, Yumi Sugawara, Takashi Watanabe, Masako Kakizaki, Yoshikazu Nishino, Shinichi Kuriyama, Ichiro Tsuji

    CANCER EPIDEMIOLOGY　38　(2)　129-136　2014/04

    DOI： 10.1016/j.canep.2014.01.001 　

    ISSN： 1877-7821

    eISSN： 1877-783X

  482. Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis Peer-reviewed

    Kei Asayama, Lutgarde Thijs, Jana Brguljan-Hitij, Teemu J. Niiranen, Atsushi Hozawa, José Boggia, Lucas S. Aparicio, Azusa Hara, Jouni K. Johansson, Takayoshi Ohkubo, Christophe Tzourio, George S. Stergiou, Edgardo Sandoya, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen, K. Asayama, T. Ohkubo, M. Kikuya, R. Inoue, M. Satoh, M. Hosaka, M. T. Utsugi, T. Hirose, A. Hara, N. Fukushima, T. Obara, H. Metoki, Y. Imai, J. Johansson, A. Reunanen, A. Jula, K. Ohmori-Matsuda, S. Kuriyama, M. Kakizaki, A. Hozawa, I. Tsuji, T. Mountokalakis, A. Kollias, G. Thomopoulou, P. Kalogeropoulos, I. Skeva, E. Nasothimiou, N. Pantazis, N. Baibas, J. Boggia, E. Sandoya, J. A. Staessen, L. Thijs, N. Cauwenberghs, Z. Zhang, F. Wei, J. Knez, A. Odili, Y. Gu, Y. Liu, Y. Jin, L. Jacobs, T. Kuznetzova

    PLoS Medicine　11　(1)　e1001591　2014/01/01

    Publisher: Public Library of Science

    DOI： 10.1371/journal.pmed.1001591 　

    ISSN： 1549-1676 1549-1277

  483. The velocity of home blood pressure reduction in response to low-dose eplerenone combined with other antihypertensive drugs determined by exponential decay function analysis Peer-reviewed

    Noha Elnagar, Michihiro Satoh, Miki Hosaka, Kei Asayama, Kazuki Ishikura, Taku Obara, Nariyasu Mano, Takayoshi Ohkubo, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　36　(2)　83-91　2014

    DOI： 10.3109/10641963.2014.892117 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  484. Aldosterone-to-renin ratio and nocturnal blood pressure decline assessed by self-measurement of blood pressure at home: the Ohasama Study Peer-reviewed

    Michihiro Satoh, Miki Hosaka, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Megumi T. Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Takefumi Mori, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

    CLINICAL AND EXPERIMENTAL HYPERTENSION　36　(2)　108-114　2014

    DOI： 10.3109/10641963.2014.892121 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  485. Night-time blood pressure is associated with the development of chronic kidney disease in a general population: The Ohasama Study Peer-reviewed

    Atsuhiro Kanno, Masahiro Kikuya, Kei Asayama, Michihiro Satoh, Ryusuke Inoue, Miki Hosaka, Hirohito Metoki, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Toshinobu Sato, Yoshio Taguma, Hiroshi Sato, Yutaka Imai, Takayoshi Ohkubo

    Journal of Hypertension　31　(12)　2410-2417　2013/12

    DOI： 10.1097/HJH.0b013e328364dd0f 　

    ISSN： 0263-6352 1473-5598

  486. 日本の一般地域住民におけるセルフメディケーションに関する実態調査

    佐藤 倫広, 松本 章裕, 原 梓, 岩森 紗希, 菊谷 昌浩, 小原 拓, 目時 弘仁, 小野木 弘志, 高橋 信行, 佐藤 博, 眞野 成康, 今井 潤, 大久保 孝義

    日本補完代替医療学会学術集会プログラム・抄録集　16回　58-58　2013/11

    Publisher: 日本補完代替医療学会

  487. 周産期の葉酸摂取の重要性に関する薬剤師の認識

    小原 拓, 佐藤 倫広, 小野木 弘志, 眞野 成康, 村井 ユリ子

    日本補完代替医療学会学術集会プログラム・抄録集　16回　64-64　2013/11

    Publisher: 日本補完代替医療学会

  488. 微量アルブミン尿を呈する高血圧症患者に対するイルベサルタン単独治療および併用治療が腎機能、家庭血圧に及ぼす効果 多施設共同無作為比較研究(J-HOMEアルブミン研究)

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 小原 拓, 佐藤 倫広, 今井 潤

    日本高血圧学会総会プログラム・抄録集　36回　269-269　2013/10

    Publisher: (NPO)日本高血圧学会

  489. 一般地域住民における、家庭血圧および24時間血圧に基づく真性および部分白衣高血圧と脳卒中発症の関連 大迫研究

    佐藤 倫広, 菊谷 昌浩, 浅山 敬, 井上 隆輔, 宇津木 恵[坪田], 原 梓, 廣瀬 卓男, 小原 拓, 目時 弘仁, 戸恒 和人, 星 晴久, 眞野 成康, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　36回　321-321　2013/10

    Publisher: (NPO)日本高血圧学会

  490. Logistic regression analysis of risk factors for prolonged pulmonary recovery in children from aspirated foreign body Peer-reviewed

    Hiroshi Hidaka, Taku Obara, Shinichi Kuriyama, Shin Kurosawa, Yukio Katori, Toshimitsu Kobayashi

    International Journal of Pediatric Otorhinolaryngology　77　(10)　1677-1682　2013/10

    DOI： 10.1016/j.ijporl.2013.07.024 　

    ISSN： 0165-5876 1872-8464

  491. 小児の注意欠陥/多動性障害患者に対する医薬品処方

    小原 拓, 佐藤 倫広, 村井 ユリ子, 眞野 成康, 栗山 進一

    日本医薬品情報学会総会・学術大会講演要旨集　16回　131-131　2013/08

    Publisher: (一社)日本医薬品情報学会

  492. インターネット上の「葉酸と妊娠」に関する情報の現状

    村井 ユリ子, 猪狩 有紀恵, 石黒 真美, 佐藤 倫広, 小原 拓

    日本医薬品情報学会総会・学術大会講演要旨集　16回　139-139　2013/08

    Publisher: (一社)日本医薬品情報学会

  493. 葉酸と出生児の神経管閉鎖障害リスク抑制に関する薬学生の認識

    大原 宏司, 小原 拓, 佐藤 倫広, 眞野 成康, 佐藤 博, 早坂 正孝, 村井 ユリ子

    日本医薬品情報学会総会・学術大会講演要旨集　16回　140-140　2013/08

    Publisher: (一社)日本医薬品情報学会

  494. 東日本大震災後に薬品情報室に寄せられた問い合わせに関する調査

    吉中 千佳, 尾崎 芙実, 小原 拓, 草場 美津江, 前川 麻央, 松浦 正樹, 佐賀 利英, 中村 浩規, 久道 周彦, 佐藤 真由美, 我妻 恭行, 眞野 成康

    日本病院薬剤師会雑誌　49　(8)　877-881　2013/08

    Publisher: (一社)日本病院薬剤師会

    ISSN： 1341-8815

  495. 薬剤師における医薬品安全性評価に関する認識および実践に関する調査

    山口 浩明, 小原 拓, 佐藤 倫広, 青木 良子, 天沼 喜美子, 村井 ユリ子, 宮本 剛典, 高村 茂生, 山田 武宏, 眞野 成康, 井関 健

    日本医薬品情報学会総会・学術大会講演要旨集　16回　122-122　2013/08

    Publisher: (一社)日本医薬品情報学会

  496. 周産期における葉酸摂取の重要性に関する薬剤師の認識

    酒井 隆全, 小原 拓, 竹林 まゆみ, 水野 恵司, 杉浦 尚子, 竹内 一仁, 大津 史子, 村井 ユリ子

    日本医薬品情報学会総会・学術大会講演要旨集　16回　140-140　2013/08

    Publisher: (一社)日本医薬品情報学会

  497. 妊娠期間中の家庭血圧は正常であったが急速に妊娠高血圧腎症・子癇発作を発症した1例 Peer-reviewed

    目時 弘仁, 渋谷 祐介, 岩間 憲之, 片桐 未希子, 小原 拓, 菊谷 昌浩, 大久保 孝義, 西郡 秀和, 佐藤 尚明, 田中 耕平, 星 和彦, 鈴木 雅洲, 今井 潤, 菅原 準一, 八重樫 伸生

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　2回　152-152　2013/05

    Publisher: (NPO)日本高血圧学会

  498. ラニチジン注とファモチジン注のパクリタキセル注前投与におけるアレルギー発現率の比較

    片岡 佑太, 菊地 正史, 中川 直人, 木皿 重樹, 高橋 哉子, 小笠原 喜美代, 我妻 恭行, 久道 周彦, 小原 拓, 鈴木 直人, 村井 ユリ子, 島田 美樹, 富岡 佳久, 石岡 千加史, 眞野 成康

    日本薬学会年会要旨集　133年会　(4)　184-184　2013/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  499. Breastfeeding leads to lower blood pressure in 7-year-old Japanese children: Tohoku Study of Child Development (vol 36, pg 117, 2012) Peer-reviewed

    Hosaka Miki, Asayama Kei, Staessen Jan A, Ohkubo Takayoshi, Hayashi Katsuhisa, Tatsuta Nozomi, Kurokawa Naoyuki, Satoh Michihiro, Hashimoto Takanao, Hirose Takuo, Obara Taku, Metoki Hirohito, Inoue Ryusuke, Kikuya Masahiro, Nakai Kunihiko, Imai Yutaka, Satoh Hiroshi

    HYPERTENSION RESEARCH　36　(2)　184　2013/02

    DOI： 10.1038/hr.2012.203 　

    ISSN： 0916-9636

  500. 妊婦における葉酸サプリメント摂取の評価BOSHI研究 Peer-reviewed

    小原 拓, 村井 ユリ子, 眞野 成康

    医薬品相互作用研究　37　37-43　2013

  501. Compliance to the recommendations on blood pressure measurements in the clinical settings. Peer-reviewed

    Obara Taku, Ohkubo Takayoshi, Mano Nariyasu, Kuriyama Shinichi, Imai Yutaka

    J Hypertens　31　(1)　213-213　2013/01

    DOI： 10.1097/HJH.0b013e32835aaffd 　

    ISSN： 0263-6352

  502. カンデサルタン8mg/HCTZ6.25mg配合剤とカンデサルタン12mgの家庭血圧/外来血圧に及ぼす作用に関する多施設共同無作為比較試験(J-HOME-CARD研究) 主結果報告

    今井 潤, 保坂 実樹, 目時 弘仁, 佐藤 倫広, 小原 拓, 菊谷 昌浩, 大久保 孝義, J-HOME-CARD研究グループ

    日本高血圧学会総会プログラム・抄録集　35回　468-468　2012/09

    Publisher: (NPO)日本高血圧学会

  503. Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study Peer-reviewed

    Atsuhiro Kanno, Masahiro Kikuya, Takayoshi Ohkubo, Takanao Hashimoto, Michihiro Satoh, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoh Shishido, Haruhisa Hoshi, Masaaki Nakayama, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

    NEPHROLOGY DIALYSIS TRANSPLANTATION　27　(8)　3218-3223　2012/08

    DOI： 10.1093/ndt/gfs054 　

    ISSN： 0931-0509

  504. Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama Study Peer-reviewed

    Shiho Terata, Masahiro Kikuya, Michihiro Satoh, Takayoshi Ohkubo, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

    JOURNAL OF HYPERTENSION　30　(8)　1632-1638　2012/08

    DOI： 10.1097/HJH.0b013e328354f65b 　

    ISSN： 0263-6352

  505. Aldosterone-to-Renin Ratio as a Predictor of Stroke Under Conditions of High Sodium Intake: The Ohasama Study Peer-reviewed

    Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Azusa Hara, Megumi T. Utsugi, Takanao Hashimoto, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　25　(7)　777-783　2012/07

    DOI： 10.1038/ajh.2012.33 　

    ISSN： 0895-7061

  506. 東日本大震災後に薬品情報室に寄せられた問い合わせに関する調査

    吉中 千佳, 尾崎 芙実, 小原 拓, 前川 麻央, 草場 美津江, 佐賀 利英, 我妻 恭行, 久道 周彦, 眞野 成康

    日本医薬品情報学会総会・学術大会講演要旨集　15回　120-120　2012/06

    Publisher: (一社)日本医薬品情報学会

  507. Predictive Value for Mortality of the Double Product at Rest Obtained by Home Blood Pressure Measurement: The Ohasama Study Peer-reviewed

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　25　(5)　568-575　2012/05

    DOI： 10.1038/ajh.2012.3 　

    ISSN： 0895-7061

  508. うつ症状、労働状況、および睡眠薬・抗不安薬服用状況に関する社団法人仙台市薬剤師会による実態調査

    佐藤 倫広, 小原 拓, 高橋 將喜, 早坂 正孝, 鎌田 裕, 北村 哲治

    医薬品相互作用研究　35　(3)　153-158　2012/04

    Publisher: (一社)医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    平成22年9月から平成23年1月に、保険薬局施設に来局した20歳以上の366名を対象に、鬱傾向、労働状況、睡眠薬・不安薬服用状況を調査した。鬱傾向があるのは35名で、鬱傾向の有無で年齢、性別および労働者の割合に差はみられなかった。睡眠薬・抗不安薬服用の割合は、鬱傾向無し群22.4%に比べ、鬱傾向有り群では60.0%と有意に高率であった。労働有りと回答した294名において、労働体系と鬱傾向に有意な関連は認められなかった。労働状況の評価が悪くなるにしたがって、鬱傾向の割合は高くなった。鬱傾向に強く関連する因子として、「労働の深夜負担が大きい」「休憩・仮眠施設が不適切」が有意に多く選択された。

  509. Review of medication counseling records relating to pregnancy Peer-reviewed

    小原拓, 尾崎芙実, 吉中千佳, 前川麻央, 草場美津江, 石黒真美, 飯田優太郎, 鈴木文子, 松浦正樹, 佐賀利英, 佐藤真由美, 久道周彦, 島田美樹, 栗山進一, 八重樫伸生, 眞野成康

    医薬品相互作用研究　35　(3)　129-133　2012/04

    Publisher:

    ISSN： 0385-5015

  510. シンバスタチン服用前後の脂質・血糖・血圧の変化市販後調査データを用いた検討 Peer-reviewed

    小原 拓, 村井 ユリ子, 眞野 成康

    医薬品相互作用研究　36 (2)　114-119　2012

  511. 葉酸の神経管閉鎖障害リスク低下効果に関する薬剤師の認識

    小原 拓, 村井ユリ子, 猪狩有紀恵, 原 梓, 岸川幸生, 早坂正孝, 鎌田 裕, 眞野成康, 高橋将喜, 生出泉太郎, 北村哲治

    医薬品情報学　13　(4)　167-172　2012

    DOI： 10.11256/jjdi.13.167 　

  512. Validation of the Parama-Tech PS-501 Device for Office Blood Pressure Measurement According to the International Protocol Peer-reviewed

    Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Kei Asayama, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　34　(1)　71-73　2012

    DOI： 10.3109/10641963.2011.618198 　

    ISSN： 1064-1963

  513. Prognostic Significance of Home Arterial Stiffness Index Derived From Self-Measurement of Blood Pressure: The Ohasama Study Peer-reviewed

    Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Kei Asayama, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Jan A. Staessen, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　25　(1)　67-73　2012/01

    DOI： 10.1038/ajh.2011.167 　

    ISSN： 0895-7061

  514. Daily Serial Hemodynamic Data During Pregnancy and Seasonal Variation: The BOSHI Study Peer-reviewed

    Hirohito Metoki, Takayoshi Ohkubo, Taku Obara, Konomi Akutsu, Mami Yamamoto, Mami Ishikuro, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Junichi Sugawara, Takuo Hirose, Michihiro Sato, Masahiro Kikuya, Katsuyo Yagihashi, Yoichi Matsubara, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　34　(4)　290-296　2012

    DOI： 10.3109/10641963.2012.681086 　

    ISSN： 1064-1963

  515. 家庭血圧測定に基づく震災前後の家庭血圧・脈拍の推移

    佐藤 倫広, 菊谷 昌浩, 大久保 孝義, 目時 弘仁, 小原 拓, 浅山 敬, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　325-325　2011/10

    Publisher: (NPO)日本高血圧学会

  516. Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population: the Ohasama study Peer-reviewed

    Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Takanao Hashimoto, Azusa Hara, Megumi T. Utsugi, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION　29　(10)　1940-1947　2011/10

    DOI： 10.1097/HJH.0b013e32834ab46a 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  517. Subtypes of Resistant Hypertension Based on Out-of-Office Blood Pressure Measurement Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama, Yutaka Imai

    HYPERTENSION　58　(4)　E28-E28　2011/10

    DOI： 10.1161/HYPERTENSIONAHA.111.178996 　

    ISSN： 0194-911X

  518. Aldosterone-to-renin ratio and home blood pressure in subjects with higher and lower sodium intake: the Ohasama Study Peer-reviewed

    Michihiro Satoh, Masahiro Kikuya, Azusa Hara, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Megumi T. Utsugi, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION RESEARCH　34　(3)　361-366　2011/03

    DOI： 10.1038/hr.2010.236 　

    ISSN： 0916-9636

  519. How many measurements are needed to provide reliable information in terms of the ambulatory arterial stiffness index? the Ohasama study Peer-reviewed

    Masahiro Kikuya, Jan A. Staessen, Takayoshi Ohkubo, Lutgarde Thijs, Kei Asayama, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Yan Li, Eamon Dolan, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Ji-Guang Wang, Eoin O&apos;Brien, Yutaka Imai

    HYPERTENSION RESEARCH　34　(3)　314-318　2011/03

    DOI： 10.1038/hr.2010.240 　

    ISSN： 0916-9636

  520. Association of Arterial Stiffness with Silent Cerebrovascular Lesions: The Ohasama Study Peer-reviewed

    Rieko Hatanaka, Taku Obara, Daisuke Watabe, Tomofumi Ishikawa, Takeo Kondo, Kazuki Ishikura, Tomoyuki Aikawa, Yoko Aono, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Nariyasu Mano, Takayoshi Ohkubo, Shin-Ichi Izumi, Yutaka Imai

    CEREBROVASCULAR DISEASES　31　(4)　329-337　2011

    DOI： 10.1159/000322599 　

    ISSN： 1015-9770

  521. Dietary supplement use among women before and after delivery: BOSHI study Peer-reviewed

    Hara A, Obara T, Metoki H, Ohkubo T, Kawaguchi M, Sato Y, Sasaki A, Hoshikawa M, Ishikura K, Satoh M, Murai Y, Mano N, Iwasaki M, Yagihashi K, Mori S, Yaegashi N, Suzuki M, Imai Y

    Journal of Drug Interaction Research　35　(1)　11-16　2011

    Publisher:

    ISSN： 0385-5015

  522. Individual Assessment of Inherent Arterial Stiffness Using Nomogram and Pulse Wave Velocity Index: The Ohasama Study Peer-reviewed

    Rieko Hatanaka, Taku Obara, Daisuke Watabe, Atsushi Kimura, Tomohiro Hanazawa, Hiromi Ohba, Tomofumi Ishikawa, Tomoyuki Aikawa, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(3)　147-152　2011

    DOI： 10.3109/10641963.2010.531839 　

    ISSN： 1064-1963

  523. Self-Monitoring of Ambulatory Blood Pressure by the Microlife WatchBP O3-An Application Test Peer-reviewed

    Hajime Nakano, Masahiro Kikuya, Azusa Hara, Manami Nakashita, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takayoshi Ohkubo, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(1)　34-40　2011

    DOI： 10.3109/10641963.2010.503300 　

    ISSN： 1064-1963

  524. Low-Dose and Very Low-Dose Spironolactone in Combination Therapy for Essential Hypertension: Evaluation by Self-Measurement of Blood Pressure at Home Peer-reviewed

    Tomohiro Hanazawa, Taku Obara, Kei Ogasawara, Takahiro Shinki, Sakiko Katada, Ryusuke Inoue, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Nariyasu Mano, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(7)　427-436　2011

    DOI： 10.3109/10641963.2010.531844 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  525. Associated Factors of Home Versus Ambulatory Heart Rate Variability in the General Population: The Ohasama Study Peer-reviewed

    Kenta Gonokami, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(6)　404-410　2011

    DOI： 10.3109/10641963.2010.549269 　

    ISSN： 1064-1963

  526. Serum Magnesium, Ambulatory Blood Pressure, and Carotid Artery Alteration: The Ohasama Study Peer-reviewed

    Takanao Hashimoto, Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Manami Nakashita, Shiho Terata, Taku Obara, Takuo Hirose, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　23　(12)　1292-1298　2010/12

    DOI： 10.1038/ajh.2010.168 　

    ISSN： 0895-7061

  527. 家庭血圧によるHome Arterial Stiffness Index(HASI)の脳卒中発症予測能

    菊谷 昌浩, 大久保 孝義, 佐藤 倫広, 廣瀬 卓男, 橋本 貴尚, 目時 弘仁, 井上 隆輔, 小原 拓, 浅山 敬, 星 晴久, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　33回　283-283　2010/10

    Publisher: (NPO)日本高血圧学会

  528. 薬剤師における家庭血圧測定に関する認識と実践

    小林 満, 小原 拓, 田中 宏治, 佐藤 倫広, 生出 泉太郎, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　33回　418-418　2010/10

    Publisher: (NPO)日本高血圧学会

  529. 家庭血圧測定に基づくドキサゾシンメシル酸塩錠の臨床評価 先発医薬品(カルデナリン錠)から後発医薬品(カデメシン錠・メシル酸ドキサゾシン「MEEK」錠)への切り替え

    池田 うらら, 小原 拓, 新木 貴大, 芝宮 拓, 石倉 一樹, 佐藤 倫広, 大久保 孝義, 吉田 克己, 今井 潤

    医薬品相互作用研究　34　(1)　7-12　2010/09

    Publisher: (一社)医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    ドキサゾシンメシル酸塩の先発医薬品(カルデナリン錠)から後発医薬品(カデメシン錠、メシル酸ドキサゾシン「MEEK」錠)に切り替えた際のドキサゾシンの有効性に関する評価を行った。先発医薬品継続群、後発医薬品への切替群に群別して後ろ向き調査を行い、基準日、基準日の28日後、56日後の早朝家庭血圧・心拍と外来随時血圧・心拍を評価した。その結果、先発医薬品から後発医薬品への切替前後において、外来随時血圧および早朝家庭血圧の推移や服薬アドヒアランスに明らかな差はなく、各群間の血圧変化量に有意差を認めなかった。また、先発医薬品と後発医薬品の血圧管理の差に関する検出力の比較では、外来随時血圧測定よりも家庭血圧測定を用いた場合のほうが高かった。

  530. Relationship of dysregulation of glucose metabolism with white-coat hypertension: the Ohasama study Peer-reviewed

    Miki Hosaka, Akira Mimura, Kei Asayama, Takayoshi Ohkubo, Katsuhisa Hayashi, Masahiro Kikuya, Michihiro Sato, Takanao Hashimoto, Atsuhiro Kanno, Azusa Hara, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Haruhisa Hoshi, Hiroshi Satoh, Yoshitomo Oka, Yutaka Imai

    HYPERTENSION RESEARCH　33　(9)　937-943　2010/09

    DOI： 10.1038/hr.2010.114 　

    ISSN： 0916-9636

  531. Factors Associated With Day-By-Day Variability of Self-Measured Blood Pressure at Home: The Ohasama Study Peer-reviewed

    Tetsuo Kato, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Azusa Hara, Taku Obara, Hirohito Metoki, Kei Asayama, Takuo Hirose, Ryusuke Inoue, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　23　(9)　980-986　2010/09

    DOI： 10.1038/ajh.2010.94 　

    ISSN： 0895-7061

  532. Practice and awareness of physicians regarding casual-clinic blood pressure measurement in Japan Peer-reviewed

    Mitsuru Kobayashi, Taku Obara, Takayoshi Ohkubo, Hidefumi Fukunaga, Michihiro Satoh, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Masaaki Miyakawa, Yutaka Imai

    Hypertension Research　33　(9)　960-964　2010/09

    DOI： 10.1038/hr.2010.89 　

    ISSN： 0916-9636 1348-4214

  533. Electrocardiographic abnormalities and home blood pressure in treated elderly hypertensive patients: Japan home versus office blood pressure measurement evaluation in the elderly (J-HOME-Elderly) study Peer-reviewed

    Taku Shibamiya, Taku Obara, Takayoshi Ohkubo, Takahiro Shinki, Kazuki Ishikura, Makoto Yoshida, Michihiro Satoh, Takanao Hashimoto, Azusa Hara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Yutaka Imai

    HYPERTENSION RESEARCH　33　(7)　670-677　2010/07

    DOI： 10.1038/hr.2010.55 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  534. Stroke Risk in Treated Hypertension Based on Home Blood Pressure: the Ohasama Study Peer-reviewed

    Daisaku Yasui, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Atsuhiro Kanno, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　23　(5)　508-514　2010/05

    DOI： 10.1038/ajh.2010.15 　

    ISSN： 0895-7061

    eISSN： 1941-7225

  535. Practice and awareness of physicians regarding home blood pressure measurement in Japan Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Hidefumi Fukunaga, Mitsuru Kobayashi, Michihiro Satoh, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Masaaki Miyakawa, Yutaka Imai

    Hypertension Research　33　(5)　428-434　2010/05

    DOI： 10.1038/hr.2010.10 　

    ISSN： 0916-9636 1348-4214

  536. 高血圧患者における一包化調剤対応服薬コンプライアンス計の臨床応用

    西村 美里, 小原 拓, 駒井 理恵, 村井 華代, 田中 宏治, 加藤 哲夫, 佐藤 倫広, 原 梓, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 今井 潤

    医薬品相互作用研究　33　(3)　97-102　2010/04

    Publisher: (一社)医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    服薬忘れの防止、過服薬の防止、服薬状況の正確な記録とその分析を目的とした一包化調剤対応服薬コンプライアンス計を開発した。開発したコンプライアンス計を用いて、臨床現場においてその有効性および使用感を検証した。高血圧外来を受診し、降圧薬を含む多剤の朝1回もしくは朝晩2回一包化処方を受けている比較的コンプライアンス良好な22例を対象とした。使用開始時の服薬コンプライアンスは97.1%であった。使用感に関するコメントは17例から寄せられた。使用感が悪かったとするコメントのうち、設定・記録が正しいか不安である、ACアダプタによる電源供給では置き場所が限られる、停電時に不便であるというコメントが多かった。家庭血圧解析対象者は装置使用期間中に処方変更がなく、家庭血圧、随時血圧および外来自己測定血圧に有意差は認めなかった。

  537. Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study Peer-reviewed

    Yumiko Watanabe, Hirohito Metoki, Takayoshi Ohkubo, Tomohiro Katsuya, Yasuharu Tabara, Masahiro Kikuya, Takuo Hirose, Ken Sugimoto, Kei Asayama, Ryusuke Inoue, Azusa Hara, Taku Obara, Jun Nakura, Katsuhiko Kohara, Kazuhito Totsune, Toshio Ogihara, Hiromi Rakugi, Tetsuro Miki, Yutaka Imai

    HYPERTENSION RESEARCH　33　(2)　129-134　2010/02

    DOI： 10.1038/hr.2009.193 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  538. Parental longevity and offspring's home blood pressure: the Ohasama study Peer-reviewed

    Yumiko Watanabe, Hirohito Metoki, Takayoshi Ohkubo, Takuo Hirose, Masahiro Kikuya, Kei Asayama, Ryusuke Inoue, Azusa Hara, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION　28　(2)　272-277　2010/02

    DOI： 10.1097/HJH.0b013e328332fa78 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  539. Blood Pressure-Lowering Effect and Duration of Action of Bedtime Administration of Doxazosin Determined by Home Blood Pressure Measurement Peer-reviewed

    Kenta Gonokami, Taku Obara, Mitsuru Kobayashi, Sakiko Katada, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　32　(5)　311-317　2010

    DOI： 10.3109/10641960903443541 　

    ISSN： 1064-1963

  540. Validation of the FM-800 Ambulatory Blood Pressure Monitor According to the Association for the Advancement of Medical Instrumentation Criteria and the International Protocol Peer-reviewed

    Kaori Nakamura, Masahiro Kikuya, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Takayoshi Ohkubo, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　32　(8)　523-527　2010

    DOI： 10.3109/10641963.2010.496513 　

    ISSN： 1064-1963

  541. Association of Kidney Dysfunction with Silent Lacunar Infarcts and White Matter Hyperintensity in the General Population: The Ohasama Study Peer-reviewed

    Harunori Otani, Masahiro Kikuya, Azusa Hara, Shiho Terata, Takayoshi Ohkubo, Takeo Kondo, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Hiroyuki Terawaki, Masaaki Nakayama, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

    CEREBROVASCULAR DISEASES　30　(1)　43-50　2010

    DOI： 10.1159/000313612 　

    ISSN： 1015-9770

    eISSN： 1421-9786

  542. Uncontrolled hypertension based on morning and evening home blood pressure measurements from the J-HOME study Peer-reviewed

    Taku Obara, Kie Ito, Takayoshi Ohkubo, Taku Shibamiya, Takahiro Shinki, Manami Nakashita, Azusa Hara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Nariyasu Mano, Yutaka Imai

    HYPERTENSION RESEARCH　32　(12)　1072-1078　2009/12

    DOI： 10.1038/hr.2009.152 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  543. 降圧効果安定までの期間と降圧効果についてのロサルタン/HCTZとARB最大容量との比較 J-HOME-AI研究

    目時 弘仁, 堅田 早紀子, 小原 拓, 菅野 厚博, 大久保 孝義, 今井 潤, J-HOME-AI研究グループ

    日本高血圧学会総会プログラム・抄録集　32回　282-282　2009/10

    Publisher: (NPO)日本高血圧学会

  544. Influence of home blood pressure measuring conditions in the evening on the morning-evening home blood pressure difference in treated hypertensive patients: the J-HOME study Peer-reviewed

    Kie Ito, Taku Obara, Takayoshi Ohkubo, Kenta Gonokami, Takahiro Shinki, Taku Shibamiya, Manami Nakashita, Mitsuru Kobayashi, Jin Funahashi, Azusa Hara, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Yutaka Imai

    BLOOD PRESSURE MONITORING　14　(4)　160-165　2009/08

    DOI： 10.1097/MBP.0b013e32832e2a40 　

    ISSN： 1359-5237

  545. Repeated evening home blood pressure measurement improves prognostic significance for stroke: a 12-year follow-up of the Ohasama study Peer-reviewed

    Kei Asayama, Takayoshi Ohkubo, Azusa Hara, Takuo Hirose, Daisaku Yasui, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    BLOOD PRESSURE MONITORING　14　(3)　93-98　2009/06

    DOI： 10.1097/MBP.0b013e32832a9d91 　

    ISSN： 1359-5237

  546. Detection of silent cerebrovascular lesions in individuals with &apos;masked&apos; and &apos;white-coat&apos; hypertension by home blood pressure measurement: the Ohasama study Peer-reviewed

    Azusa Hara, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Yoko Aono, Sugiko Hanawa, Kyoko Shioda, Sayaka Miyamoto, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takuo Hirose, Kazuhito Totsune, Haruhisa Hoshi, Shin-Ichi Izumi, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION　27　(5)　1049-1055　2009/05

    DOI： 10.1097/HJH.0b013e3283298522 　

    ISSN： 0263-6352

  547. Day-by-Day Variability of Blood Pressure and Heart Rate at Home as a Novel Predictor of Prognosis The Ohasama Study Peer-reviewed

    Masahiro Kikuya, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Azusa Hara, Taku Obara, Ryusuke Inoue, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION　52　(6)　1045-1050　2008/12

    DOI： 10.1161/HYPERTENSIONAHA.107.104620 　

    ISSN： 0194-911X

  548. 大迫研究から 日本の高血圧治療ガイドラインに基づいた脳卒中リスク分類

    浅山 敬, 大久保 孝義, 菊谷 昌浩, 廣瀬 卓男, 原 梓, 菅野 厚博, 安井 大策, 小原 拓, 目時 弘仁, 井上 隆輔, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    血圧　15　(10)　902-903　2008/10

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    高血圧治療ガイドライン2004(JSH2004)のリスク分類を非高血圧の集団にまで拡大した場合の脳卒中発症リスクを、とくに正常高値血圧に着目して評価した。35歳以上で家庭血圧(HBP)を3回(3日)以上測定し、外来随時血圧(CBP)も測定した2368例を対象とした。観察期間中に174例の初発脳卒中を認めた。至適血圧を基準とした場合の脳卒中の発症リスクは、HBP、CBPいずれにもとづいた場合でも血圧段階の上昇に伴って直線的に増加し、HBPにもとづいた場合は正常高値血圧者も至適血圧者にくらべ有意なリスク上昇を示した。JSH2004リスク分類を拡大して対象を4群に分類した場合、低リスク群であっても正常群にくらべて有意な脳卒中発症リスクを認め、対象の脳卒中の発症リスクは分類群の上昇に伴って直線的に増加した。

  549. 家庭血圧導入の医療経済学的評価 外来血圧コントロール良好高血圧患者における検討

    田巻 佑一朗, 中川 美和, 大久保 孝義, 小林 慎, 福永 英史, 菊谷 昌浩, 小原 拓, 原 梓, 浅山 敬, 目時 弘仁, 井上 隆輔, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　207-207　2008/10

    Publisher: (NPO)日本高血圧学会

  550. 高血圧治療ガイドラインに基づいたリスク分類 大迫研究

    浅山 敬, 大久保 孝義, 菊谷 昌浩, 廣瀬 卓男, 原 梓, 菅野 厚博, 安井 大策, 小原 拓, 目時 弘仁, 井上 隆輔, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　208-208　2008/10

    Publisher: (NPO)日本高血圧学会

  551. 自由行動下心拍短期変動と家庭心拍日間変動の規定要因に関する検討 大迫研究

    後ノ上 健太, 菊谷 昌浩, 大久保 孝義, 原 梓, 目時 弘仁, 浅山 敬, 井上 隆輔, 小原 拓, 廣瀬 卓男, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　214-214　2008/10

    Publisher: (NPO)日本高血圧学会

  552. AASIおよび24時間脈圧の再現性・予後予測能 全血圧値および一部の血圧値による検討 大迫研究

    菊谷 昌浩, Staessen Jan A., 大久保 孝義, Thijs Lutgarde, 目時 弘仁, 浅山 敬, 小原 拓, 井上 隆輔, Li Yan, Dolan Eamon, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, Wang Ji-Guang, O'Brien Eoin, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　284-284　2008/10

    Publisher: (NPO)日本高血圧学会

  553. 血清マグネシウム濃度・24時間自由行動下血圧と頸動脈硬化指標との関連 大迫研究

    橋本 貴尚, 原 梓, 大久保 孝義, 菊谷 昌浩, 新谷 依子, 目時 弘仁, 井上 隆輔, 浅山 敬, 菅野 厚博, 中下 愛実, 小原 拓, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　285-285　2008/10

    Publisher: (NPO)日本高血圧学会

  554. 家庭ダブルプロダクトと予後 大迫研究より

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 原 梓, 廣瀬 卓男, 菅野 厚博, 小原 拓, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　286-286　2008/10

    Publisher: (NPO)日本高血圧学会

  555. 非飲酒者における就寝前家庭血圧の有用性 大迫研究

    浅山 敬, 大久保 孝義, 菅野 厚博, 原 梓, 廣瀬 卓男, 安井 大策, 小原 拓, 目時 弘仁, 井上 隆輔, 菊谷 昌浩, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　313-313　2008/10

    Publisher: (NPO)日本高血圧学会

  556. わが国の家庭血圧測定の現状と変化 外来患者の実践と意識"家庭血圧測定の現状に関する調査研究-2"

    大久保 孝義, 小原 拓, 原 梓, 小林 満, 目時 弘仁, 浅山 敬, 菊谷 昌宏, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　316-316　2008/10

    Publisher: (NPO)日本高血圧学会

  557. Predictive value of ambulatory heart rate in the Japanese general population: the Ohasama study Peer-reviewed

    Atsushi Hozawa, Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Azusa Hara, Takuo Hirose, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION　26　(8)　1571-1576　2008/08

    ISSN： 0263-6352

  558. 脂質異常症患者における先発医薬品(ベザトールSR)から後発医薬品(ベザテートSR)への切り替えに関する臨床評価

    小原 拓, 高橋 將喜, 高橋 則男, 高橋 武, 小林 寛子, 猪狩 有紀恵, 大久保 孝義, 齋藤 真一郎, 眞野 成康, 今井 潤

    医薬品相互作用研究　32　(1)　33-37　2008/07

    Publisher: 医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    仙台逓信病院では平成12年7月にフィブラート系脂質異常症治療薬であるベザフィブラートについて、先発医薬品であるベザトールSRから後発品医薬品ベザテートSRに切り替えた。この切り替えを行った脂質異常症患者26名(男性8名、女性18名、平均57.0±16.0歳)を対象として、切り替え前後の有効性及び安全性等について後ろ向き調査を行った。その結果、後発医薬品の6ヵ月間服用継続率は96.2%であった。カルテ閲覧に同意が得られ、かつ臨床評価が可能であった患者10名においては、有効性、安全性及び服薬コンプライアンスに明らかな差は認められなかった。

  559. 脂質異常症治療薬の後発医薬品への切り替えと服薬コンプライアンスの変化

    小原 拓, 高橋 將喜, 高橋 則男, 高橋 武, 小林 寛子, 猪狩 有紀恵, 齋藤 真一郎, 大久保 孝義, 眞野 成康, 今井 潤

    ジェネリック研究　2　(増刊号)　74-74　2008/06

    Publisher: 日本ジェネリック医薬品・バイオシミラー学会

    ISSN： 1881-9117

  560. Difference between home and office blood pressures among treated hypertensive patients from the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study Peer-reviewed

    Tsuyoshi Horikawa, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    HYPERTENSION RESEARCH　31　(6)　1115-1123　2008/06

    ISSN： 0916-9636

  561. Optimal cutoff point of waist circumference and use of home blood pressure as a definition of metabolic syndrome: The Ohasama study Peer-reviewed

    Atsushi Sato, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Azusa Hara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshitomo Oka, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　21　(5)　514-520　2008/05

    DOI： 10.1038/ajh.2007.88 　

    ISSN： 0895-7061

  562. 血清マグネシウム濃度と頸動脈硬化指標の横断的検討 大迫研究

    橋本 貴尚, 新谷 依子, 原 梓, 菊谷 昌浩, 大久保 孝義, 大谷 陽範, 田中 一翔, 浅山 敬, 井上 隆輔, 目時 弘仁, 小原 拓, 森戸 里衣子, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本循環器病予防学会誌　43　(1)　77-86　2008/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  563. Cost-effectiveness of the introduction of home blood pressure measurement in patients with office hypertension Peer-reviewed

    Hidefumi Fukunaga, Takayoshi Ohkubo, Makoto Kobayashi, Yuichiro Tamaki, Masahiro Kikuya, Taku Obara, Miwa Nakagawa, Azusa Hara, Kei Asayama, Hirohito Metoki, Ryusuke Inoue, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION　26　(4)　685-690　2008/04

    ISSN： 0263-6352

    eISSN： 1473-5598

  564. 日本の高血圧診療に家庭血圧測定を導入した場合の費用対効果分析

    福永 英史, 田巻 佑一朗, 小原 拓, 戸恒 和人, 鈴木 一夫, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 橋本 潤一郎, 今井 潤, 小林 慎, 中川 美和, 浅山 敬

    医療経済研究　19　(3)　211-232　2008/03

    Publisher: 医療経済研究機構

    ISSN： 1340-895X

  565. Home blood pressure measurements associated with better blood pressure control: the J-HOME study Peer-reviewed

    T. Obara, T. Ohkubo, K. Asayama, H. Metoki, R. Inoue, M. Kikuya, T. Kato, K. Tanaka, A. Hara, J. Hashimoto, K. Totsune, Y. Imai

    JOURNAL OF HUMAN HYPERTENSION　22　(3)　197-204　2008/03

    DOI： 10.1038/sj.jhh.1002320 　

    ISSN： 0950-9240

  566. Time-dependent effects of imidapril administration in patients with morning hypertension measured as home blood pressure Peer-reviewed

    Takako Shibasaki, Taku Obara, Takayoshi Ohkubo, Azusa Hara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　30　(3-4)　243-254　2008

    DOI： 10.1080/10641960802069806 　

    ISSN： 1064-1963

  567. Prevalence of masked hypertension in subjects treated with antihypertensive drugs as assessed by morning versus evening home blood pressure measurements: The J-HOME study Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Rie Komai, Kayo Murai, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　30　(3-4)　277-287　2008

    DOI： 10.1080/10641960802071018 　

    ISSN： 1064-1963

  568. II型糖尿病患者におけるボグリボースの先発医薬品(ベイスン)と後発医薬品(ボグリダーゼ)の臨床的評価 Peer-reviewed

    小原 拓, 高橋 將喜, 高橋 則男, 高橋 武, 小林 寛子, 猪狩 有紀恵, 菊池 大輔, 村井 華代, 田中 宏治, 大久保 孝義, 齋藤 真一郎, 今井 潤

    ジェネリック研究　1　(2)　85-91　2007/12

    Publisher: 日本ジェネリック医薬品・バイオシミラー学会

    ISSN： 1881-9117

  569. Evaluation of efficacy and safety of manidipine hydrochloride among essential hypertensive patients - Substitution from branded product (Calslot (R)) to generic product (Manidip (R)) Peer-reviewed

    Hiroko Kobayashi, Taku Obara, Norio Takahashi, Takeshi Takahashi, Yukie Igari, Takuya Oikawa, Shinichiro Saito, Takayoshi Ohkubo, Yutaka Imai, Masanobu Takahashi

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　127　(12)　2045-2050　2007/12

    ISSN： 0031-6903

  570. Incorporating self-blood pressure measurements at home in the guideline from the Ohasama study Peer-reviewed

    Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Azusa Hara, Ryusuke Inoue, Taku Obara, Takuo Hirose, Rieko Hatanaka, Atsushi Hozawa, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    BLOOD PRESSURE MONITORING　12　(6)　407-409　2007/12

    DOI： 10.1097/MBP.0b013e328244e8a7 　

    ISSN： 1359-5237

  571. Factors affecting heart rate as measured at home among treated hypertensive patients: The Japan Home versus Office blood pressure Measurement Evaluation (J-HOME) study Peer-reviewed

    Rie Komai, Taku Obara, Takayoshi Ohkubo, Tetsuo Kato, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Azusa Hara, Koji Tanaka, Kenta Gonokami, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    HYPERTENSION RESEARCH　30　(11)　1051-1057　2007/11

    ISSN： 0916-9636

  572. 本邦の高血圧治療にJSH2004が与えた影響 J-HOME研究

    小原 拓, 大久保 孝義, 加藤 哲夫, 田中 宏治, 浅山 敬, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 原 梓, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　153-153　2007/10

    Publisher: (NPO)日本高血圧学会

  573. 日本人のメタボリックシンドローム診断における家庭血圧の有用性ならびにウエスト周囲径基準値についての検討 大迫研究

    佐藤 敦, 浅山 敬, 大久保 孝義, 菊谷 昌浩, 小原 拓, 目時 弘仁, 井上 隆輔, 原 梓, 原 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　154-154　2007/10

    Publisher: (NPO)日本高血圧学会

  574. 家庭血圧による各血圧因子の持つ脳卒中発症予測能の比較 大迫研究

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 小原 拓, 廣瀬 卓男, 原 梓, 森戸 里衣子, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　176-176　2007/10

    Publisher: (NPO)日本高血圧学会

  575. 随時血圧・自由行動下血圧・家庭血圧 頸動脈病変と最も強く関連しているのはどれか? 大迫研究

    田中 一翔, 原 梓, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 小原 拓, 大谷 陽範, 井上 隆輔, 浅山 敬, 森戸 里衣子, 廣瀬 卓男, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　180-180　2007/10

    Publisher: (NPO)日本高血圧学会

  576. 降圧治療中患者において家庭血圧測定より得られた血圧日間変動の規定因子

    加藤 哲夫, 菊谷 昌浩, 小原 拓, 大久保 孝義, 原 梓, 目時 弘仁, 井上 隆輔, 浅山 敬, 廣瀬 卓男, 森戸 里衣子, 田中 宏治, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　237-237　2007/10

    Publisher: (NPO)日本高血圧学会

  577. 若年女性における月経周期と家庭血圧・脈拍との関連

    目時 弘仁, 渡邉 悠美子, 西村 美里, 大久保 孝義, 菊谷 昌浩, 森戸 里衣子, 原 梓, 廣瀬 卓男, 田村 知子, 小原 拓, 菅野 厚博, 浅山 敬, 井上 隆輔, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　238-238　2007/10

    Publisher: (NPO)日本高血圧学会

  578. 家庭血圧測定経験の有無と降圧治療 J-HOME研究より

    小原 拓, 大久保 孝義, 浅山 敬, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 加藤 哲夫, 田中 宏治, 原 梓, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　250-250　2007/10

    Publisher: (NPO)日本高血圧学会

  579. 自由行動下血圧による血圧短期変動と家庭血圧による血圧日間変動 大迫研究

    菊谷 昌浩, 大久保 孝義, 目時 弘仁, 浅山 敬, 原 梓, 小原 拓, 井上 隆輔, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　251-251　2007/10

    Publisher: (NPO)日本高血圧学会

  580. 白衣高血圧・仮面高血圧における高感度C反応性蛋白 大迫研究

    原 梓, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 小原 拓, 大谷 陽範, 田中 一翔, 井上 隆輔, 浅山 敬, 森戸 里衣子, 廣瀬 卓男, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　264-264　2007/10

    Publisher: (NPO)日本高血圧学会

  581. 正常高値血圧のリスク評価と、高血圧治療ガイドラインへの家庭血圧導入の有用性 大迫研究

    浅山 敬, 大久保 孝義, 佐藤 敦, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 小原 拓, 原 梓, 廣瀬 卓男, 森戸 里衣子, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　270-270　2007/10

    Publisher: (NPO)日本高血圧学会

  582. 腎機能障害と無症候性脳血管障害との関連 大迫研究

    大谷 陽範, 原 梓, 大久保 孝義, 菊谷 昌浩, 近藤 健男, 小原 拓, 目時 弘仁, 井上 隆輔, 浅山 敬, 菅野 厚博, 森戸 里衣子, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 出江 伸一, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　277-277　2007/10

    Publisher: (NPO)日本高血圧学会

  583. 本邦における家庭血圧測定の現状 医師、薬剤師、患者における実践と意識

    田中 宏治, 小原 拓, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 浅山 敬, 橋本 潤一郎, 戸恒 和人, 真野 少, 生出 泉太郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　278-278　2007/10

    Publisher: (NPO)日本高血圧学会

  584. 家庭血圧測定に基づくフェノフィブラートの降圧効果 Peer-reviewed

    石川 智史, 小原 拓, 片岡 裕貴, 花澤 智大, 田中 宏治, 芝宮 拓, 森戸 里衣子, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 戸恒 和人, 橋本 潤一郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　282-282　2007/10

    Publisher: (NPO)日本高血圧学会

  585. Control of home heart rate and home blood pressure levels in treated patients with hypertension: the J-HOME study Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Rie Komai, Kei Asayama, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Kayo Murai, Koji Tanaka, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    BLOOD PRESSURE MONITORING　12　(5)　289-295　2007/10

    ISSN： 1359-5237

  586. 早朝高血圧患者におけるオルメサルタンとアムロジピンの薬効比較

    佐藤 茜, 小原 拓, 大久保 孝義, 井上 奈緒, 目時 弘仁, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 橋本 潤一郎, 戸恒 和人, 今井 潤

    臨床高血圧　13　(3)　199-207　2007/09

    Publisher: (株)メディカルレビュー社

    ISSN： 1342-2154

    More details Close

    早朝高血圧患者に対するアンジオテンシンII受容体拮抗薬であるオルメサルタンとCa拮抗薬であるアムロジピンの薬効を家庭血圧に基づいて比較検討した。オルメサルタン投与群(A群)は25症例(男性18例、女性7例、平均59.2±8.9歳、10mg投与7例・20mg投与18例)、アムロジピン投与群(B群)は25症例(男性15例、女性10例、61.3±8.7歳、2.5mg投与7例・5mg投与18例)を対象とした。家庭血圧は早朝と就寝前に各1回ずつ患者自身が上腕型カフ式自動血圧測定装置にて測定した。薬効持続の評価には早朝の降圧度(M値)と就寝前の降圧度(E値)から算出のM/E比を用い、対象者個人ごとに得られるM/E比平均のindividual M/E比と対象者全員のM値をE値で除したoverall M/E比を算出した。対象の年齢・性別・糖尿病合併(A群28.0%・B群4.0%)以外の合併症・危険因子には差を認めなかった。その結果、両群とも薬剤投与開始2週間後から早朝・就寝前家庭血圧は有意に低下し、両群間に降圧度の差は認めなかった。心拍数はA群では有意な変化を認めなかったが、B群では就寝前心拍数が有意に上昇した。収縮期血圧におけるindividual M/E比はA群1.12±0.73・B群1.08±0.71,overall M/E比はA群1.23・B群0.99であった。拡張期血圧におけるindividual M/E比はA群1.00±0.51・B群0.86±0.49,overall M/E比はA群1.08・B群1.26であった。薬剤投与4週後の早朝家庭血圧目標値(収縮期血圧<135mmHg・拡張期血圧<85mmHg)達成率は両群とも24.0%で、拡張期血圧単独の達成率はA群33.3%・B群24.0%、拡張期血圧単独の達成率はA群33.3%・B群55.0%と2群間に有意差は認めなかった。以上より両薬剤共に1日1回投与で十分な薬効持続と降圧を示し、早朝高血圧治療に有用な降圧薬と考えられた。

  587. 家庭血圧測定に基づくフェノフィブラートの降圧効果評価 Peer-reviewed

    石川 智史, 小原 拓, 片岡 裕貴, 花澤 智大, 田中 宏治, 芝宮 拓, 森戸 里衣子, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 戸恒 和人, 橋本 潤一郎, 今井 潤

    Therapeutic Research　28　(9)　1853-1862　2007/09

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

    More details Close

    高血圧で高トリグリセリド(TG)血症を合併した57例(男39名、女18名、平均63.7±10.2歳)のうち50例にフェノフィブラート(FF)を67mg、1例に100mg、6例に134mgを4週間服用させ、診療所随時血圧(CBP)、家庭血圧(HBP)、各種生化学検査値への影響を調べた。全例が降圧薬(アンジオテンシンII受容体拮抗薬、カルシウム拮抗薬、β-遮断薬、利尿薬)を、12例がスタチン系高脂血症治療薬を服用していた。FFは血清中の尿酸、トリグリセリド、総コレステロールなどを低下させた。CBP、随時心拍は減少傾向を示したが、有意差は認めなかった。HBP、家庭心拍は収縮期血圧、拡張期血圧、心拍共にFF服用により有意な低下を認めた。FF低用量(67mg投与群)より、高用量(100・134mg投与群)服用者の方が大きな降圧、心拍の低下を認めた。

  588. Ambulatory blood pressure, blood pressure variability and the prevalence of carotid artery alteration: the Ohasama study Peer-reviewed

    Yoriko Shintani, Masahiro Kikuya, Azusa Hara, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Yoko Aono, Takanao Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION　25　(8)　1704-1710　2007/08

    ISSN： 0263-6352

  589. Reproducibility of nocturnal blood pressure assessed by self-measurement of blood pressure at home Peer-reviewed

    Keiko Hosohata, Masahiro Kikuya, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION RESEARCH　30　(8)　707-712　2007/08

    ISSN： 0916-9636

  590. Out-of-office blood pressure control among treated subjects Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Yutaka Imai

    HYPERTENSION　49　(6)　E40-E41　2007/06

    DOI： 10.1161/HYPERTENSIONAHA.107.090993 　

    ISSN： 0194-911X

  591. 家庭血圧にもとづく選択的AT1受容体拮抗薬オルメサルタンの臨床的評価

    井上 奈緒, 小原 拓, 大久保 孝義, 佐藤 茜, 中川 美和, 橋本 貴尚, 皆川 加奈, 渡邉 悠美子, 目時 弘仁, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 橋本 潤一郎, 戸恒 和人, 今井 潤

    血圧　14　(2)　205-212　2007/02

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    新規ARBであるオルメサルタンの臨床的有効性に関して、家庭血圧測定にもとづいて検討した。未治療の早朝高血圧患者25例を対象とした。治療期間としてオルメサルタン10mgまたは20mgを1日1回朝食後に投与した。就寝前収縮期血圧、早朝収縮期血圧、就寝前拡張期血圧、早朝拡張期血圧はいずれもオルメサルタン投与により有意な降圧を認めた。オルメサルタン投与による家庭心拍の有意な変化は認めなかったが、低下傾向を認めた。治療前の家庭血圧は早朝、就寝前ともにメタボリックシンドロームの有無で有意差は認めなかった。早朝家庭心拍はメタボリックシンドロームを有さない群ではわずかに上昇したのに対して、メタボリックシンドロームを有する群では減少がみられた。メタボリックシンドロームを有さない群にくらべ、有する群での就寝前心拍の減少度は大きかった。

  592. ACE阻害薬塩酸イミダプリルの早朝家庭血圧に及ぼす影響

    芝崎 貴子, 小原 拓, 大久保 孝義, 目時 弘仁, 菊谷 昌浩, 浅山 敬, 橋本 潤一郎, 戸恒 和人, 今井 潤

    血圧　14　(1)　99-104　2007/01

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    家庭血圧測定により、塩酸イミダプリルの早朝高血圧に対する有効性を服用時間別に検討した。対象を朝食後服用群57例、就寝前服用群30例に分けた。早朝収縮期血圧、就寝前収縮期血圧は、服用時間、服用量(塩酸イミダプリル2.5mg、5.0mg)に関わらず低下し、早朝収縮期血圧の低下率は就寝前収縮期血圧よりも大きかった。心拍数は、服用時間、服用量に関わらず、有意な上昇はなかった。翌朝までの降圧効果は、ほぼ良好(長時間作用型)であった。塩酸イミダプリルは、朝食後、又は就寝前の1日1回服用で、早朝の血圧高値に有効であることが示された。高血圧患者における早朝の血圧レベルと脳卒中リスクには有意な関連が認められ、塩酸イミダプリルは早朝高血圧の治療を介して、高血圧患者における脳卒中リスク軽減に有用である可能性が示唆された。

  593. 29-A3-10-2 家庭血圧測定に基づくフェノフィブラートの降圧効果(薬剤疫学・医薬品情報,社会の期待に応える医療薬学を) Peer-reviewed

    石川 智史, 大久保 孝義, 戸恒 和人, 橋本 潤一郎, 今井 潤, 小原 拓, 片岡 裕貴, 花澤 智大, 田中 宏治, 芝宮 拓, 森戸 里衣子, 浅山 敬, 菊谷 昌浩

    日本医療薬学会年会講演要旨集　17　(0)　188-188　2007

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.17.0_188_2 　

  594. Blood pressure lowering effect of fenofibrate evaluated by home blood pressure Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Hiroki Kataoka, Tomohiro Hanazawa, Koji Tanaka, Taku Shibamiya, Rieko H. Morito, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Kazuhito Totsune, Junichiro Hashimoto, Yutaka Imai

    Therapeutic Research　28　(9)　1853-1862　2007

    ISSN： 0289-8020

  595. Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study: Status at February 2004 Peer-reviewed

    Keiko Hosohata, Shin Saito, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Taku Obara, Tetsuo Kato, Junichiro Hashimoto, Kazuhito Totsune, Yukio Miura, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　29　(1)　69-81　2007/01

    DOI： 10.1080/10641960601096976 　

    ISSN： 1064-1963

  596. Current usage of diuretics among hypertensive patients in Japan: The Japan home versus office blood pressure measurement evaluation (J-HOME) study Peer-reviewed

    Kayo Murai, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Takuya Oikawa, Ryusuke Inoue, Rie Komai, Tsuyoshi Horikawa, Kei Asayama, Masahiro Kikuya, Kazuhito Totsune, Junichiro Hashimoto, Yutaka Imai

    HYPERTENSION RESEARCH　29　(11)　857-863　2006/11

    ISSN： 0916-9636

  597. 家庭血圧測定経験の有無と降圧治療 J-HOME研究より

    小原 拓, 大久保 孝義, 浅山 敬, 目時 弘仁, 井上 隆輔, 菊谷 昌浩, 橋本 潤一郎, 戸恒 和人, 今井 潤

    血圧　13　(10)　1128-1129　2006/10

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    2003年に実施された家庭血圧測定に関する全国調査「J-HOME研究」より、家庭血圧測定経験の有無による降圧治療および血圧コントロール状況について検討した。その結果、対象者2363名のうち家庭血圧測定経験ありの高血圧患者は1820名(77%)、経験なしの高血圧患者は543名(23%)であった。家庭血圧測定経験ありの患者では、α遮断薬の使用・夕食後または就寝前服用の割合が高く、特に朝の血圧を考慮した積極的な降圧治療が行われていると同時に、各種血圧管理が良好であることが確認された。

  598. 家庭血圧に基づいた高血圧管理ガイドラインの有用性 大迫研究

    浅山 敬, 大久保 孝義, 小原 拓, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    血圧　13　(10)　1130-1131　2006/10

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    高血圧管理ガイドラインとして米国のJNC7とヨーロッパの2003ESH-ESCの我が国の一般住民に対する妥当性を検討し、基礎情報として随時血圧の代わりに家庭血圧を用いた場合のガイドラインの有用性を検証した。その結果、初発脳卒中の発症予測の観点からは、JNC7、2003ESH-ESCいずれのカイドラインも我が国の一般住民において有用であることが確認された。更に血圧値の基準を家庭血圧においた場合、その発症予測能が著明に上昇することが証明され、家庭血圧の重要性が改めて裏付けられた。

  599. 高校生における血圧値および高血圧基準値の認識に関する調査成績(05')

    小原 拓, 大久保 孝義, 目時 弘仁, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 橋本 潤一郎, 戸恒 和人, 今井 潤

    Health Sciences　22　(4)　576-576　2006/10

    Publisher: (一社)日本健康科学学会

    ISSN： 0911-7024

  600. The economic impact of the introduction of home blood pressure measurement for the diagnosis and treatment of hypertension Peer-reviewed

    Jin Funahashi, Takayoshi Ohkubo, Hidefumi Fukunaga, Masahiro Kikuya, Noriko Takada, Kei Asayama, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Junichiro Hashimoto, Kazuhito Totsune, Makoto Kobayashi, Yutaka Imai

    BLOOD PRESSURE MONITORING　11　(5)　257-267　2006/10

    ISSN： 1359-5237

  601. Prediction of stroke by home "morning" versus "evening" blood pressure values - The Ohasama study Peer-reviewed

    Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Azusa Hara, Takuo Hirose, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION　48　(4)　737-743　2006/10

    DOI： 10.1161/01.HYP.0000240332.01877.11 　

    ISSN： 0194-911X

  602. Characteristics of resistant hypertension determined by self-measured blood pressure at home and office blood pressure measurements: the J-HOME study Peer-reviewed

    Takuya Oikawa, Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Rie Komai, Kayo Murai, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　(9)　1737-1743　2006/09

    ISSN： 0263-6352

  603. The current status of home and office blood pressure control among hypertensive patients with diabetes mellitus: The Japan Home Versus Office Blood Pressure Measurement Evaluation (J-HOME) study Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Ryusuke Inoue, Takuya Oikawa, Kayo Murai, Rie Komai, Tsuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    DIABETES RESEARCH AND CLINICAL PRACTICE　73　(3)　276-283　2006/09

    DOI： 10.1016/j.diabres.2006.01.015 　

    ISSN： 0168-8227

  604. [Practical use of self-measured blood pressure at home]. Peer-reviewed

    Obara T, Imai Y, Asayama K

    Nihon rinsho. Japanese journal of clinical medicine　64 Suppl 6　5-9　2006/08

    ISSN： 0047-1852

  605. わが国における家庭血圧測定の現状 外来患者8,506人の実践と意識"家庭血圧測定の現状に関する調査研究"

    小原 拓, 大久保 孝義, 菊谷 昌浩, 福永 英史, 村井 華代, 浅山 敬, 目時 弘仁, 橋本 潤一郎, 戸恒 和人, 今井 潤

    血圧　13　(4)　447-454　2006/04

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    全国の院外処方箋薬局に来局した現在何らかの疾病で受診中の外来患者を対象として,家庭血圧測定に関するアンケート調査を行い,非高血圧患者も含めた外来患者における家庭血圧測定の実践と認識の実態について調査した.高血圧の有無にかかわらず,わが国において家庭血圧計はきわめて広汎に普及していた.8割以上の患者が少なくとも月に数回以上家庭血圧を測定していたが,血圧基準値の認識率はきわめて低かった.医師による家庭血圧測定の推奨が患者の正確な家庭血圧測定の普及に効果的であることが明らかとなった

  606. 本邦における利尿薬使用の現状

    村井 華代, 小原 拓, 大久保 孝義, 及川 卓也, 駒井 理恵, 堀川 剛, 菊谷 昌浩, 浅山 敬, 井上 隆輔, 目時 弘仁, 戸恒 和人, 橋本 潤一郎, 今井 潤

    日本薬学会年会要旨集　126年会　(2)　155-155　2006/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  607. わが国における家庭血圧測定の現状 医師1,928人の実践と意識"家庭血圧測定の現状に関する調査研究"

    福永 英史, 大久保 孝義, 小原 拓, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 橋本 潤一郎, 戸恒 和人, 今井 潤

    血圧　13　(1)　122-128　2006/01

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    全国の医師を対象として自己測定血圧(家庭血圧:HBP)測定に関するアンケート調査をおこない,医師におけるHBP測定の実践と認識の実態について調査した.アンケートに回答した医師は全体で1928人で,内科系の医師が1603人と最も多かった.朝のHBP測定条件に対し,医師による指導の遵守状況は,起床後1時間以内と指導するもの1622人,排尿後908人,座位1331人,1〜2分の安静後535人,朝食前1393人,服薬前1349人であった.また,晩のHBP測定は,就眠前に測定するよう指導する医師が998人であった.さらに,これらすべての指導をJSH2004の推奨どおりに行い得ている医師は190人で,内科医においてその比率が高い傾向を認めた.内科医について年代別に比較すると,30〜60代においてJSH2004の推奨を遵守している比率が高い傾向を認めた

  608. Prevalence of masked uncontrolled and treated white-coat hypertension defined according to the average of morning and evening home blood pressure value: from the Japan Home versus Office Measurement Evaluation Study Peer-reviewed

    T Obara, T Ohkubo, M Kikuya, K Asayama, H Metoki, R Inoue, T Oikawa, R Komai, K Murai, T Horikawa, J Hashimoto, K Totsune, Y Imai

    BLOOD PRESSURE MONITORING　10　(6)　311-316　2005/12

    ISSN： 1359-5237

  609. 血漿フィブリノーゲン値と無症候性脳血管障害との関連大迫研究

    青野 蓉子, 菊谷 昌浩, 原 梓, 大久保 孝義, 近藤 健男, 浅山 敬, 井上 隆輔, 目時 弘仁, 小原 拓, 新谷 依子, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 出江 伸一, 今井 潤

    日本循環器病予防学会誌　40　(3)　181-189　2005/10

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

    More details Close

    岩手県大迫町の一般地域住民を対象に,フィブリノーゲンと無症候性脳血管障害(ラクナ梗塞・脳室周囲高信号域(PVH))との関連について,横断的に検討した.ラクナ梗塞の数が多い群ほど,フィブリノーゲン値は有意に高値であった.各種危険因子で補正後も,フィブリノーゲンの1SD(63.5mg/dl)上昇ごとのラクナ梗塞のオッズ比は1.29と有意であった.フィブリノーゲンと24時間自由行動下血圧はそれぞれ独立してラクナ梗塞と関連し,両方高値の群はラクナ梗塞を有するオッズ比が2.50倍と著しく高値であった.フィブリノーゲンとPVHに関連は認めなかった.フィブリノーゲンとラクナ梗塞との関連が示唆された.フィブリノーゲンはラクナ梗塞の危険因子あるいは予測因子として応用の可能性があると考えられた

  610. Use of 2003 European Society of Hypertension-European Society of Cardiology guidelines for predicting stroke using self-measured blood pressure at home: the Ohasama study Peer-reviewed

    K Asayama, T Ohkubo, M Kikuya, H Metoki, T Obara, H Hoshi, J Hashimoto, K Totsune, H Satoh, Y Imai

    EUROPEAN HEART JOURNAL　26　(19)　2026-2031　2005/10

    DOI： 10.1093/eurheartj/ehi330 　

    ISSN： 0195-668X

  611. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP Study)中間報告:2005年2月末における割付け状況および家庭血圧値の推移,HOMED-BP研究グループを代表して

    大久保 孝義, 浅山 敬, 小原 拓, 目時 弘仁, 齊藤 伸, 細畑 圭子, 橋本 潤一郎, 戸恒 和人, 三浦 幸雄, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　21-21　2005/09

    Publisher: (NPO)日本高血圧学会

  612. 朝晩の家庭血圧測定値の臨床的有用性 脳卒中発症予測能の観点から 大迫研究

    浅山 敬, 大久保 孝義, 小原 拓, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　32-32　2005/09

    Publisher: (NPO)日本高血圧学会

  613. 24時間自由行動下血圧測定から得られる4つの血圧因子(収縮期血圧,拡張期血圧,平均血圧および脈圧)の脳卒中発症予測能

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 小原 拓, 橋本 潤一郎, 戸恒 和人, 星 晴久, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　64-64　2005/09

    Publisher: (NPO)日本高血圧学会

  614. 白衣高血圧・仮面高血圧の頸動脈病変:大迫研究

    原 梓, 大久保 孝義, 菊谷 昌浩, 小原 拓, 目時 弘仁, 井上 隆輔, 浅山 敬, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　69-69　2005/09

    Publisher: (NPO)日本高血圧学会

  615. 一包化調剤対応服薬コンプライアンス計の開発と臨床応用

    今井 潤, 大久保 孝義, 小原 拓, 菊谷 昌宏, 浅山 敬, 目時 弘仁, 橋本 潤一郎, 戸恒 和人

    日本高血圧学会総会プログラム・抄録集　28回　163-163　2005/09

    Publisher: (NPO)日本高血圧学会

  616. 異なる病型の脳卒中発症に対する一日の各時間帯における血圧のリスクの比較検討 大迫研究

    目時 弘仁, 大久保 孝義, 菊谷 昌浩, 浅山 敬, 小原 拓, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　175-175　2005/09

    Publisher: (NPO)日本高血圧学会

  617. 自由行動下血圧測定による血圧短期変動および心拍短期変動の脳卒中予後予測能 大迫研究

    菊谷 昌浩, 大久保 孝義, 浅山 敬, 目時 弘仁, 井上 隆輔, 小原 拓, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　182-182　2005/09

    Publisher: (NPO)日本高血圧学会

  618. 家庭血圧における治療抵抗性高血圧の要因に関する検討 J-HOME研究

    及川 卓也, 小原 拓, 大久保 孝義, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　183-183　2005/09

    Publisher: (NPO)日本高血圧学会

  619. 本邦における家庭血圧測定の現状-2 一般市民の実践と意識

    大久保 孝義, 小原 拓, 菊谷 昌宏, 浅山 敬, 目時 弘仁, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　202-202　2005/09

    Publisher: (NPO)日本高血圧学会

  620. 本邦における家庭血圧測定の現状-1 医師1704人の実践と意識"家庭血圧測定の現状に関する調査研究"協力者を代表して

    今井 潤, 大久保 孝義, 小原 拓, 菊谷 昌宏, 浅山 敬, 目時 弘仁, 橋本 潤一郎, 戸恒 和人

    日本高血圧学会総会プログラム・抄録集　28回　204-204　2005/09

    Publisher: (NPO)日本高血圧学会

  621. 家庭血圧による夜間血圧,夜間血圧降下度の評価 大迫研究

    細畑 圭子, 菊谷 昌浩, 大久保 孝義, 浅山 敬, 目時 弘仁, 小原 拓, 井上 隆輔, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　205-205　2005/09

    Publisher: (NPO)日本高血圧学会

  622. 日本全国の降圧治療中の本態性高血圧患者における早朝家庭血圧および就寝前家庭血圧管理状況 J-HOME研究グループを代表して

    小原 拓, 大久保 孝義, 舟橋 仁, 及川 卓也, 菊谷 昌宏, 浅山 敬, 目時 弘仁, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　28回　207-207　2005/09

    Publisher: (NPO)日本高血圧学会

  623. 家庭血圧による血圧日間変動の脳卒中予測能

    菊谷 昌浩, 大久保 孝義, 浅山 敬, 目時 弘仁, 小原 拓, 井上 隆輔, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    血圧　12　(9)　990-991　2005/09

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    35歳以上の住民2,578人を対象として家庭血圧を測定し,血圧日間変動と予後との関連を検討した.男女比は4:6,平均年齢は61歳,平均測定日数は23日であった.対象を血圧日間変動で5均等分割し,相対危険度を分析した.その結果,収縮期平均血圧は123.9±14.9mmHg,拡張期平均血圧は74.7±9.9mmHg,収縮期血圧日間変動は8.6±3.3mmHg,拡張期血圧日間変動は6.4±2.5mmHgであった.家庭内血圧測定の完了後,約10年の観察期間に164例の脳卒中を認めた.血圧日間変動最大群では最小群と比較して脳卒中発症のリスクが有意に上昇した.脳卒中病型別の血圧日間変動は脳梗塞発症と有意に関連したが,脳出血との相関は認めなかった.家庭血圧による血圧日間変動の増大は虚血性脳卒中の独立危険因子であることが示唆された

  624. Isolated uncontrolled hypertension at home and in the office among treated hypertensive patients from the J-HOME study Peer-reviewed

    T Obara, T Ohkubo, J Funahashi, M Kikuya, K Asayama, H Metoki, T Oikawa, J Hashimoto, K Totsune, Y Imai

    JOURNAL OF HYPERTENSION　23　(9)　1653-1660　2005/09

    ISSN： 0263-6352

  625. White-coat hypertension as a risk factor for the development of home hypertension: The Ohasama study Peer-reviewed

    Takashi Ugajin, Atsushi Hozawa, Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Ichiro Tsuji, Yutaka Imai

    Archives of Internal Medicine　165　(13)　1541-1546　2005/07/11

    DOI： 10.1001/archinte.165.13.1541 　

    ISSN： 0003-9926

  626. 【管理不良高血圧/治療抵抗性高血圧へのアプローチ】対策 真の管理不良高血圧例と白衣性管理不良高血圧例とをどう鑑別するか,どう対応すればよいか

    渡部 大介, 橋本 潤一郎, 小原 拓, 今井 潤

    Modern Physician　25　(2)　159-162　2005/02

    Publisher: (株)新興医学出版社

    ISSN： 0913-7963

  627. インターネットを介した家庭血圧にもとづく降圧療法に関する大規模介入試験(HOMED-BP研究)中間報告 2004年2月末における割付け状況と血圧推移

    齊藤 伸, 細畑 圭子, 浅山 敬, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 小原 拓, 橋本 潤一郎, 戸恒 和人, 三浦 幸雄, 今井 潤, HOMED-BP研究グループ

    血圧　12　(1)　127-135　2005/01

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    わが国の高血圧診療における第一選択薬として,幅広く用いられているCa拮抗薬,ACE阻害薬,およびARBに注目し,この3系統の降圧薬の比較,および2つの降圧目標レベルの比較を,家庭血圧を評価基準に据えて行った.今回,中間解析として,2004年2月末時点におけるランダム化割付状況の把握,およびランダム化割付後12ヵ月経過した患者の血圧推移などを評価した.2004年2月末日時点において,患者のランダム化割付け,および追跡が順調に遂行されていることを確認できた

  628. Prediction of ischaemic and haemorrhagic stroke by self-measured blood pressure at home: the Ohasama study Peer-reviewed

    T Ohkubo, K Asayama, M Kikuya, H Metoki, T Obara, S Saito, H Hoshi, J Hashimoto, K Totsune, H Satoh, Y Imai

    BLOOD PRESSURE MONITORING　9　(6)　315-320　2004/12

    ISSN： 1359-5237

  629. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP)研究 2004年2月末における現状報告および低値群降圧目標未達成の要因分析

    齊藤 伸, 細畑 圭子, 浅山 敬, 大久保 孝義, 菊谷 昌浩, 小原 拓, 目時 弘仁, 橋本 潤一郎, 三浦 幸雄, 今井 潤

    日本高血圧学会総会プログラム・抄録集　27回　16-16　2004/10

    Publisher: (NPO)日本高血圧学会

  630. 糖尿病合併高血圧患者における家庭血圧および外来血圧管理状況

    小原 拓, 大久保 孝義, 舟橋 仁, 菊谷 昌浩, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　27回　147-147　2004/10

    Publisher: (NPO)日本高血圧学会

  631. The second progress report on the Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study Peer-reviewed

    S Saito, K Asayama, T Ohkubo, M Kikuya, H Metoki, T Obara, J Hashimoto, K Totsune, M Yukio, Y Imai

    BLOOD PRESSURE MONITORING　9　(5)　243-247　2004/10

    ISSN： 1359-5237

  632. Control of blood pressure as measured at home and office, and comparison with physicians' assessment of control among treated hypertensive patients in Japan: First report of the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study Peer-reviewed

    T Ohkubo, T Obara, J Funahashi, M Kikuya, K Asayama, H Metoki, T Oikawa, H Takahashi, J Hashimoto, K Totsune, Y Imai

    HYPERTENSION RESEARCH　27　(10)　755-763　2004/10

    ISSN： 0916-9636

  633. 高校生における高血圧/正常血圧基準値の認識に関する調査成績

    小原 拓, 木村 淳史, 齊藤 伸, 高田 紀子, 舟橋 仁, 浅山 敬, 宇賀神 卓嗣, 佐藤 ともみ, 中村 洋介, 村松 靖子, 高橋 久樹, 原 梓, 原澤 俊也, 広瀬 卓男, 渡部 大介, 目時 弘仁, 菊谷 昌浩, 大久保 孝義, 橋本 潤一郎, 戸恒 和人, 今井 潤

    保健の科学　46　(8)　623-629　2004/08

    Publisher: (株)杏林書院

    ISSN： 0018-3342

    More details Close

    高校生を主な対象者とした高血圧の基準値の認識率に関する調査を実施した.アンケートに高校生1009人,成人96人が参加し,回答状況は高血圧基準値を記入したのは高校生865人(85.7%),成人85人(88.5%)であった.申告された基準値に関しては,高校生では申告基準値のばらつきが大きく認識率が低いのに対して,成人では140/90mmHgを含む範囲に申告基準値が集中しており,認識率が高いと考えられた.高校生においては,男子が女子よりも基準値認識率が大であった.高血圧者は高校生の7.4%(男子13.9%,女子2.5%)で,既報告よりも大であった.心拍数と血圧は密接に関係していることが示された.血圧測定値が高血圧であった者は基準値認識率が高く,正常血圧者は基準値認識率が低いという傾向があった.高校生では高血圧への関心が低く,その中で基準値を認識している者は,過去の検診等で実際に血圧が高いと診断され,二次的に基準値を認識した可能性が考えられる

  634. 家庭血圧コントロール状況に関する全国調査研究第一次報告:対象者の特性および主治医による家庭血圧値の評価「家庭血圧コントロール状況に関する全国調査研究グループ」を代表して

    大久保 孝義, 菊谷 昌浩, 小原 拓, 舟橋 仁, 橋本 潤一郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集　26回　51-51　2003/10

    Publisher: (NPO)日本高血圧学会

  635. 家庭血圧コントロール状況に関する全国調査研究(J-HOME研究)中間報告 2003年4月末における対象患者1533人の家庭血圧状況

    大久保 孝義, 小原 拓, 舟橋 仁, 菊谷 昌浩, 橋本 潤一郎, 今井 潤

    Therapeutic Research　24　(9)　1849-1855　2003/09

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

    More details Close

    全国の主治医の下で外来降圧薬治療を受けている本態性高血圧患者における大規模調査で,今回の中間報告では2003年4月末における対象患者1533例に関する分析結果について報告した.早朝家庭収縮期血圧値と外来随時収縮期血圧値の間には有意な正の相関があった.脳血管障害,虚血性心疾患の既往は各々9%,8%に認められた.対象者の13%,41%,13%が各々糖尿病,高脂血症,高尿酸血症を有していた.平均服薬期間は2.3年,平均服用降圧薬数は1.8剤で,単剤投与者が47%,2剤併用者が37%,3剤以上の降圧薬併用者は17%であった.降圧薬種別では,カルシウム拮抗薬が70%と最も多かった.早朝家庭高血圧群及び高血圧群は,正常血圧群及び外来高血圧群に比べ高齢で,早朝家庭血圧値が高値であり,平均服用降圧薬数が多く,単剤服用者の割合が小であった.外来高血圧群,高血圧群の外来随時血圧値は,正常血圧群及び早朝家庭高血圧群に比べ有意に高値であった

  636. Trisomy 18 mosaicism associated with secondary amenorrhea: Ratios of mosaicism in different samples and complications Peer-reviewed

    S. Uehara, Y. Obara, T. Obara, T. Funato, N. Yaegashi, T. Fukaya, A. Yajima

    Clinical Genetics　49　(2)　91-94　1996/02

    ISSN： 0009-9163

Show all ︎Show first 5

Misc. 372

  1. 日本人集団を対象とした皮質下構造の関連遺伝子の探索

    篠田元気, 篠田元気, 小原拓, 小原拓, 高橋一平, 大瀬戸恒志, 野田あおい, 野田あおい, 石黒真美, 石黒真美, 村上慶子, 大類真嗣, 大類真嗣, 大類真嗣, 中谷直樹, 中谷直樹, 成田暁, 成田暁, 田宮元, 田宮元, 麦倉俊司, 麦倉俊司, 布施昇男, 布施昇男, 寳澤篤, 寳澤篤, 鈴木匡子, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　35th　2025

  2. 東北メディカル・メガバンク機構(宮城)における循環器疾患発症調査の進捗

    畑中里衣子, 畑中里衣子, 時岡紗由理, 時岡紗由理, 千葉一平, 千葉一平, 小暮真奈, 小暮真奈, 中谷久美, 中谷久美, 高瀬雅仁, 高瀬雅仁, 石黒真美, 石黒真美, 薄田海, 薄田海, 大類真嗣, 大類真嗣, 大類真嗣, 後岡広太郎, 後岡広太郎, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 小原拓, 小原拓, 中谷直樹, 中谷直樹, 栗山進一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤

    日本疫学会学術総会講演集(Web)　35th　2025

  3. 日本人を対象としたつわりのゲノムワイド関連解析:三世代コホート調査

    米沢祐大, 米沢祐大, 高橋一平, 大瀬戸恒志, 上野史彦, 大沼ともみ, 野田あおい, 野田あおい, 野田あおい, 村上慶子, 石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　34th　2024

  4. 大規模レセプトデータベースを用いて妊娠中の医薬品使用と児の先天奇形の関連を評価するための研究基盤構築

    石川智史, 眞野成康, 眞野成康, 小原拓, 小原拓, 小原拓

    日本先天異常学会学術集会プログラム・抄録集　64th　2024

  5. 妊娠初期の女性へのステロイド処方と児の先天大奇形との関連に関するレセプトデータを用いた検討

    八島一史, 野田あおい, 野田あおい, 野田あおい, 岡田裕子, 石川智史, 都田桂子, 西郡秀和, 眞野成康, 小原拓, 眞野成康, 小原拓, 小原拓

    日本先天異常学会学術集会プログラム・抄録集　64th　2024

  6. 妊婦自身の出生体重と早産との関連

    工藤理永, 岩間憲之, 岩間憲之, 濱田裕貴, 富田芙弥, 田上和磨, 熊谷奈津美, 佐藤直人, 泉聖也, 櫻井かすみ, 渡邉善, 石黒真美, 石黒真美, 小原拓, 小原拓, 龍田希, 星合哲郎, 目時弘仁, 目時弘仁, 齋藤昌利, 菅原準一, 菅原準一, 栗山進一, 有馬隆弘, 八重樫伸生, 八重樫伸生

    DOHad研究(Web)　12　(3)　2024

    ISSN： 2187-2597

  7. Trends in self-measured blood pressure and indices derived from the blood pressure measurements during pregnancy and postpartum: the BOSHI study

    泉聖也, 岩間憲之, 岩間憲之, 小原拓, 小原拓, 小原拓, 石黒真美, 石黒真美, 村上任尚, 村上任尚, 佐藤倫広, 佐藤倫広, 廣瀬卓男, 大久保孝義, 今井潤, 目時弘仁, 目時弘仁

    日本高血圧学会総会プログラム・抄録集(CD-ROM)　46th　2024

  8. 「次」につなぐ「周産期医療」-次回妊娠への対策と次世代への影響を考える エコチル・スタディからみえてくるもの 三世代の解析-環境省エコチル調査と東北大学東北メディカル・メガバンク計画三世代コホート調査に基づく展望

    小原拓, 小原拓, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 篠田元気, 篠田元気, 大類真嗣, 大類真嗣, 栗山進一, 栗山進一, 栗山進一

    周産期医学　54　(4)　2024

    ISSN： 0386-9881

  9. 妊婦の睡眠障害と児のアレルギー疾患発症との関連:三世代コホート調査

    植松亜美, 大類真嗣, 大類真嗣, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 野田あおい, 篠田元気, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本衛生学雑誌(Web)　79　(Supplement)　2024

    ISSN： 1882-6482

  10. Tohoku Medical Megabank Project Three-Generation Cohort Study 10-year efforts and perinatal outcomes

    石黒真美, 小原拓, 黒田真帆, 村上慶子, 野田あおい, 篠田元気, 大類真嗣, 岩間憲之, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 寳澤篤, 栗山進一

    DOHad研究(Web)　12　(1)　2024

    ISSN： 2187-2597

  11. 両親の高血圧・糖尿病・脂質異常症の既往と娘の妊娠高血圧症候群

    石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 野田あおい, 野田あおい, 野田あおい, 篠田元気, 岩間憲之, 岩間憲之, 大類真嗣, 大類真嗣, 村上慶子, 菊谷昌浩, 目時弘仁, 寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 栗山進一

    日本妊娠高血圧学会雑誌　30　2024

    ISSN： 1880-3172

  12. 東北メディカル・メガバンク計画三世代コホート調査:小児発達に関する調査の進捗

    大類真嗣, 石黒真美, 松岡卓哉, 野田あおい, 篠田元気, 小原拓, 栗山進一, 栗山進一

    東北公衆衛生学会講演集　73rd (CD-ROM)　2024

    ISSN： 0915-549X

  13. Dietary-Wide Association Studyによる妊婦の食事摂取情報とSmall for Gestational Age児の出産との関連の探索と検証:東北メディカル・メガバンク計画三世代コホート調査

    高橋一平, 小原拓, 小原拓, 小原拓, 大瀬戸恒志, 篠田元気, 篠田元気, 野田あおい, 野田あおい, 野田あおい, 村上慶子, 村上慶子, 大類真嗣, 大類真嗣, 石黒真美, 石黒真美, 栗山進一, 栗山進一, 栗山進一

    DOHad研究(Web)　12　(3)　2024

    ISSN： 2187-2597

  14. リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

    橋本英明, 佐藤倫広, 村上任尚, 遠山真弥, 中山晋吾, 小原拓, 中谷直樹, 森建文, 寳澤篤

    日本腎臓学会誌(Web)　66　(4)　2024

    ISSN： 1884-0728

  15. Fitbitを用いた身体活動および睡眠状態の測定-進捗と測定値の特性-

    千葉一平, 千葉一平, 中谷直樹, 中谷直樹, 小暮真奈, 小暮真奈, 中谷久美, 中谷久美, 畑中里衣子, 畑中里衣子, 高瀬雅仁, 高瀬雅仁, 時岡紗由理, 時岡紗由理, 小原拓, 小原拓, 小原拓, 永家聖, 永家聖, 荻島創一, 荻島創一, 荻島創一, 麦倉俊司, 麦倉俊司, 麦倉俊司, 布施昇男, 布施昇男, 布施昇男, 長神風二, 長神風二, 長神風二, 寳澤篤, 寳澤篤

    日本公衆衛生学会総会抄録集(CD-ROM)　83rd　2024

  16. 健康的な生活習慣と新型コロナウイルス感染・新型コロナワクチン接種の効果との関連

    大類真嗣, 大類真嗣, 小原拓, 小原拓, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 村上慶子, 中村智洋, 中村智洋, 中村智洋, 目時弘仁, 目時弘仁, 目時弘仁, 中谷直樹, 中谷直樹, 寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 栗山進一

    日本公衆衛生学会総会抄録集(CD-ROM)　83rd　2024

  17. ToMMo地域住民コホートにおける閉塞性換気障害の有病と関連要因,生命予後の検討

    岩崎史, 山田充啓, 中谷久美, 中谷直樹, 中村智洋, 中村智洋, 永家聖, 荻島創一, 小原拓, 布施昇男, 泉陽子, 栗山進一, 栗山進一, 杉浦久敏, 寶澤篤

    日本公衆衛生学会総会抄録集(CD-ROM)　83rd　2024

  18. 血圧コントロール不良に対する不十分な高血圧薬物治療による影響 リアルワールドデータに基づく解析

    佐藤 倫広, 室谷 智子, 村上 任尚, 小原 拓, 浅山 敬, 大久保 孝義, 今井 潤, 目時 弘仁

    日本循環器病予防学会誌　58　(2)　146-146　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  19. 収縮期・拡張期血圧を用いた詳細血圧分類と慢性腎臓病発症リスクの関連

    末永 司, 佐藤 倫広, 村上 任尚, 廣瀬 卓男, 中山 晋吾, 小原 拓, 森 建文, 今井 潤, 大久保 孝義, 目時 弘仁

    日本循環器病予防学会誌　58　(2)　157-157　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  20. 東北メディカル・メガバンク計画三世代コホート調査の進捗と今後の計画

    石黒 真美, 小原 拓, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 目時 弘仁, 菊谷 昌浩, 菅原 準一, 中谷 直樹, 寳澤 篤, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　117-117　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  21. 大規模観察研究におけるランダム男女ペア間の循環代謝リスク因子の類似性の検討

    中谷 直樹, 中谷 久美, 土屋 菜歩, 曽根 稔雅, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 目時 弘仁, 小原 拓, 石黒 真美, 寳澤 篤, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　173-173　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  22. 母親における出産前後の社会的孤立と児の発達との関連:三世代コホート調査

    村上慶子, 野田あおい, 石黒真美, 小原拓, 上野史彦, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一, 村上慶子, 野田あおい, 石黒真美, 小原拓, 上野史彦, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一, 野田あおい, 小原拓, 岩間憲之, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一, 富田博秋

    日本衛生学雑誌(Web)　78　(Supplement)　2023

    ISSN： 1882-6482

  23. 妊婦に対するトリプタン系薬剤処方の実態:レセプトデータベースに基づく調査

    赤坂和俊, 小原拓, 小原拓, 小原拓, 有山智博, 大柳元, 森下啓, 森下啓, 小原竜, 石川智史, 眞野成康, 眞野成康

    日本医療薬学会年会講演要旨集(Web)　33rd　2023

    ISSN： 2424-2470

  24. 出生コホート連携における年齢別の不妊治療と妊娠高血圧症候群との関連

    石黒真美, 小原拓, 西村倫子, 岩田啓芳, 目時弘仁, 岩間憲之, 村上慶子, RAHMAN Shafiur, 小林澄貴, 宮下ちひろ, 石塚一枝, 田中景子, 三宅吉博, 堀川玲子, 森崎菜穂, 土屋賢治, 岸玲子, 栗山進一

    DOHad研究(Web)　11　(3)　2023

    ISSN： 2187-2597

  25. 母親の妊娠中と産後の心理的苦痛と4歳時点における児の発達との関連 三世代コホート調査

    高橋一平, 小原拓, 小原拓, 小原拓, 菊地紗耶, 菊地紗耶, 小林美佳, 小林美佳, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大沼ともみ, 松崎芙実子, 松崎芙実子, 小林奈津子, 小林奈津子, 濱田裕貴, 濱田裕貴, 岩間憲之, 岩間憲之, 齋藤昌利, 齋藤昌利, 菅原準一, 菅原準一, 富田博秋, 富田博秋, 富田博秋, 富田博秋, 呉繋夫, 呉繋夫, 八重樫伸生, 八重樫伸生, 八重樫伸生, 栗山進一, 栗山進一, 栗山進一

    DOHad研究(Web)　11　(3)　2023

    ISSN： 2187-2597

  26. 母子健康情報と学校健康診断情報との連係情報の活用可能性の検討

    篠田元気, 黒川修行, 野田あおい, 野田あおい, 大類真嗣, 大類真嗣, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 小原拓, 小原拓, 目時弘仁, 目時弘仁, 栗山進一, 栗山進一

    日本公衆衛生学会総会抄録集(CD-ROM)　82nd　2023

  27. 妊婦初期における麻黄含有漢方薬の使用と出生児の先天形態異常の関連:東北メディカル・メガバンク計画三世代コホート調査

    野田あおい, 野田あおい, 野田あおい, 小原拓, 小原拓, 小原拓, 松崎芙実子, 松崎芙実子, 小原竜, 小原竜, 森下啓, 上野史彦, 上野史彦, 篠田元気, 篠田元気, 大類真嗣, 大類真嗣, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 栗山進一, 栗山進一, 栗山進一

    日本医療薬学会年会講演要旨集(Web)　33rd　2023

    ISSN： 2424-2470

  28. 新生児臍帯血の網羅的エピゲノム解析による妊娠初期までの喫煙経験が次世代に及ぼす影響

    美辺詩織, 小巻翔平, 大桃秀樹, 高嶋聰, 小野加奈子, 山崎弥生, 須藤洋一, 田高周, 水野聖士, 石黒真美, 工藤久智, 小原拓, 熊田和貴, 勝岡史城, 荻島創一, 木下賢吾, 菅原準一, 栗山進一, 清水厚志, 清水厚志

    DOHad研究(Web)　11　(3)　2023

    ISSN： 2187-2597

  29. ゾルピデム服用中の母乳育児の安全性に関する調査

    岩渕理子, 佐藤祐司, 菊地紗耶, 小林奈津子, 松本恵実, 岡部奈穂, 前川麻央, 佐藤信一, 岩間憲之, 埴田卓志, 齋藤昌利, 富田博秋, 小原拓, 眞野成康

    日本医療薬学会年会講演要旨集(Web)　33rd　2023

    ISSN： 2424-2470

  30. TERATOGENIC RISK OF FIRST TRIMESTER EXPOSURE TO ANTIHYPERTENSIVES, INCLUDING AMLODIPINE AND METHYLDOPA: AN ANALYSIS OF AN ADMINISTRATIVE DATABASE 2010-2019

    Tomofumi Ishikawa, Hidekazu Nishigori, Manabu Akazawa, Keiko Miyakoda, Aoi Noda, Mami Ishikuro, Hirohito Metoki, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

    JOURNAL OF HYPERTENSION　41　E422-E422　2023/01

    ISSN： 0263-6352

    eISSN： 1473-5598

  31. 正常高値血圧、高値血圧における中心血圧、頸動脈内膜中膜厚と新規高血圧発症の関連

    時岡 紗由理, 中谷 直樹, 中谷 久美, 高瀬 雅仁, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 千葉 一平, 目時 弘仁, 村上 任尚, 佐藤 倫広, 小原 拓, 栗山 進一, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　44回　80-80　2022/10

    Publisher: (NPO)日本高血圧学会

  32. 赤ちゃんに対する気持ち質問票を用いた、母親の乳児へのマルトリートメントに対するスクリーニングの有用性

    森 美由紀, 西郡 俊絵, 小原 拓, 櫻井 香澄, 鈴木 妙子, 石黒 真美, 龍田 希, 齋藤 昌利, 菅原 準一, 有馬 隆博, 仲井 邦彦, 目時 弘仁, 栗山 進一, 八重樫 伸生, 西郡 秀和

    日本周産期メンタルヘルス学会学術集会抄録集　18回　54-54　2022/10

    Publisher: 日本周産期メンタルヘルス学会

  33. 年齢と骨梁面積率との関連 年齢階級別の検討 ToMMo地域住民コホート調査

    菅野 郁美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 中村 智洋, 小原 拓, 目時 弘仁, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　203-203　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  34. 心血管・代謝疾患リスク要因における配偶者同士の類似性 2ヵ国バイオバンク横断研究

    中谷 直樹, 土屋 菜歩, 成田 暁, 中村 智洋, 目時 弘仁, 小原 拓, 石黒 真美, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　81回　204-204　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  35. 妊娠中の社会的孤立と産後ボンディング障害の関連 三世代コホート調査

    村上 慶子, 小原 拓, 目時 弘仁, 栗山 進一

    日本公衆衛生学会総会抄録集　81回　330-330　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  36. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 寳澤 篤

    東北公衆衛生学会誌　(71)　28-28　2022/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  37. 妊娠前から妊娠中の降圧薬使用状況:三世代コホート調査

    石黒真美, 石黒真美, 野田あおい, 野田あおい, 野田あおい, 上野史彦, 上野史彦, 松崎芙実子, 松崎芙実子, 大沼ともみ, 村上慶子, 村上慶子, 栗山進一, 栗山進一, 栗山進一, 小原拓, 小原拓, 小原拓

    日本医薬品情報学会総会・学術大会講演要旨集　24th　2022

  38. 出生三世代ゲノムコホート研究における妊婦の妊娠前および妊娠中の医薬品使用状況

    野田あおい, 野田あおい, 野田あおい, 上野史彦, 上野史彦, 松崎芙実子, 松崎芙実子, 小原竜, 森下啓, 森下啓, 大沼ともみ, 大沼ともみ, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 栗山進一, 栗山進一, 栗山進一, 小原拓, 小原拓, 小原拓

    日本医薬品情報学会総会・学術大会講演要旨集　24th　2022

  39. 妊娠初期に禁煙した女性における産後の喫煙再開要因の検討:三世代コホート調査

    村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大沼ともみ, 松崎芙実子, 松崎芙実子, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　32nd　2022

  40. 新型コロナウイルス感染症(COVID-19)による生活の変化と健康面への影響

    松崎芙実子, 松崎芙実子, 上野史彦, 上野史彦, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 野田あおい, 大沼ともみ, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　32nd　2022

  41. 深層学習を用いたクラスタリングによる低出生体重児の原因遺伝子の探索

    大沼ともみ, 上野史彦, 上野史彦, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 野田あおい, 松崎芙実子, 松崎芙実子, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　32nd　2022

  42. 妊婦における社会的孤立と不眠との関連:三世代コホート調査

    村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大沼ともみ, 松崎芙実子, 松崎芙実子, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本衛生学雑誌(Web)　77　(Supplement)　2022

    ISSN： 1882-6482

  43. 東北メディカル・メガバンク計画三世代コホート調査 概要と進捗

    小原拓, 小原拓, 小原拓, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大沼ともみ, 大沼ともみ, 松崎芙実子, 松崎芙実子, 中谷直樹, 中谷直樹, 寳澤篤, 寳澤篤, 菅原準一, 菅原準一, 菅原準一, 栗山進一, 栗山進一, 栗山進一

    DOHad研究(Web)　10　(2)　2022

    ISSN： 2187-2597

  44. 妊娠中の降圧薬使用による血圧管理状況と児のSGAとの関連

    石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 野田あおい, 野田あおい, 野田あおい, 上野史彦, 上野史彦, 松崎芙実子, 松崎芙実子, 大沼ともみ, 大沼ともみ, 村上慶子, 村上慶子, 菊谷昌浩, 菊谷昌浩, 目時弘仁, 目時弘仁, 菅原準一, 栗山進一, 栗山進一, 栗山進一

    DOHad研究(Web)　10　(2)　2022

    ISSN： 2187-2597

  45. 肥満関連要因を用いた肥満のクラスタリングとゲノムワイド関連解析による肥満の遺伝的構造の解明

    高橋一平, 上野史彦, 上野史彦, 大沼ともみ, 大沼ともみ, 大瀬戸恒志, 成田暁, 成田暁, 野田あおい, 野田あおい, 野田あおい, 松崎芙実子, 松崎芙実子, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 寳澤篤, 寳澤篤, 田宮元, 田宮元, 田宮元, 菅原準一, 菅原準一, 栗山進一, 栗山進一, 栗山進一

    日本人類遺伝学会大会(CD-ROM)　67th　2022

  46. 母子保健情報と学校保健情報を連係した情報の活用に向けた研究 三世代コホートにおける情報収集の推進

    栗山進一, 小原拓, 松崎芙実子, 大沼ともみ, 野田あおい, 上野史彦, 村上慶子, 石黒真美, 小林雅幸

    母子保健情報と学校保健情報を連係した情報の活用に向けた研究 令和3年度 総括・分担研究年度終了報告書(Web)　2022

  47. 母子保健情報と学校保健情報を連係した情報の活用に向けた研究 学童期の疾患の発症と予後に関する検討・解析(幼児期の肥満における関連要因の検討)

    菅原準一, 菅原準一, 小原拓, 松崎芙実子, 大沼ともみ, 野田あおい, 上野史彦, 村上慶子, 石黒真美, 小林雅幸

    母子保健情報と学校保健情報を連係した情報の活用に向けた研究 令和3年度 総括・分担研究年度終了報告書(Web)　2022

  48. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 中谷 久美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　80回　219-219　2021/11

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  49. 後期早産児の乳幼児期における精神運動発達の縦断的推移

    小林美佳, 小林美佳, 石黒真美, 大沼ともみ, 村上慶子, 上野史彦, 野田あおい, 小林朋子, 小原拓, 呉繁夫, 呉繁夫, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　31st　2021

  50. 東日本大震災後の被災地における小児のアトピー性皮膚炎の有病率:三世代コホート調査

    上野史彦, 小澤麻紀, 日高高徳, 小原拓, 石黒真美, 村上慶子, 野田あおい, 大沼ともみ, 松崎芙実子, 栗山進一, 栗山進一, 相場節也

    日本疫学会学術総会講演集(Web)　31st　2021

  51. 妊娠前・妊娠中の多価不飽和脂肪酸摂取状況と妊娠中・産後のうつとの関連

    高橋一平, 小原拓, 小原拓, 小原拓, 相澤美里, 米沢祐大, 米沢祐大, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大沼ともみ, 大沼ともみ, 松崎芙実子, 松崎芙実子, 松崎芙実子, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　31st　2021

  52. 母親のパーソナリティと産後ボンディング障害との関連:三世代コホート調査

    村上慶子, 村上慶子, 上野史彦, 上野史彦, 中村伊吹, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 野田あおい, 大沼ともみ, 大沼ともみ, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　31st　2021

  53. 出生三世代ゲノムコホート研究における妊婦の妊娠前および妊娠中の医薬品の使用状況:三世代コホート調査

    野田あおい, 野田あおい, 野田あおい, 城田松之, 城田松之, 上野史彦, 上野史彦, 松崎芙実子, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 大沼ともみ, 大沼ともみ, 栗山進一, 栗山進一, 栗山進一, 小原拓, 小原拓, 小原拓

    日本疫学会学術総会講演集(Web)　31st　2021

  54. 妊婦の清涼飲料水摂取量と1歳児の過体重・肥満の関連:東北メディカル・メガバンク計画三世代コホート調査

    相澤美里, 村上慶子, 村上慶子, 米沢祐大, 米沢祐大, 高橋一平, 大沼ともみ, 大沼ともみ, 野田あおい, 野田あおい, 野田あおい, 上野史彦, 上野史彦, 松崎芙実子, 松崎芙実子, 石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    栄養学雑誌　79　(5 Supplement)　2021

    ISSN： 0021-5147

  55. 母子保健情報と学校保健情報を連係した情報の活用に向けた研究 自治体・学校・教育委員会・医療機関等における情報連係の必要性・効果・期待に関する調査

    小原拓, 大沼ともみ, 野田あおい, 上野史彦, 村上慶子, 石黒真美

    母子保健情報と学校保健情報を連係した情報の活用に向けた研究 令和2年度 総括・分担研究報告書(Web)　2021

  56. Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

    小原拓, 石黒真美, 野田あおい, 大沼ともみ, 上野史彦, 村上慶子, 栗山進一

    日本社会精神医学会雑誌　30　(1)　2021

    ISSN： 0919-1372

  57. Current situation of anticancer agents’ usage for Adolescents and Young Adult (AYA) females with cancer using an administrative claims database

    土屋雅美, 土屋雅美, 田島健太郎, 小原拓, 小原拓, 眞野成康, 眞野成康

    日本臨床腫瘍学会学術集会(CD-ROM)　18th　2021

  58. 【「今さら聞けない」をスッキリ解消する 妊娠・授乳と薬】[授乳と薬]授乳婦への服薬指導のポイントと注意点

    小原 拓

    薬事　62　(4)　761-765　2020/03

    Publisher: (株)じほう

    ISSN： 0016-5980

  59. 家系情報付き出生三世代コホートの構築に基づく成果の還元と試料・情報の分譲

    小原拓, 小原拓, 小原拓, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 菊谷昌浩, 目時弘仁, 栗山進一, 栗山進一, 栗山進一

    日本衛生学雑誌(Web)　75　(Supplement)　2020

    ISSN： 1882-6482

  60. 母親の社会的要因とボンディング障害の関連,三世代コホート調査

    中村伊吹, 上野史彦, 大柳元, 村上慶子, 石黒真美, 野田あおい, 小原拓, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  61. 東北大学東北メディカル・メガバンク計画三世代コホート調査における情報の収集・還元・分譲に関する取り組み

    小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大柳元, 菊谷昌浩, 目時弘仁, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  62. 肝臓の線維化指標と腎機能および頸動脈肥厚との関連:三世代コホート調査

    本田怜, 小原拓, 小原拓, 小原拓, 石黒真美, 石黒真美, 大柳元, 大柳元, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  63. 妊娠中の東日本大震災による家屋損壊の程度と低出生体重・早産との関連-三世代コホート調査-

    野田あおい, 野田あおい, 野田あおい, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 大柳元, 大柳元, 大柳元, 小原拓, 小原拓, 小原拓, 菅原準一, 菅原準一, 菅原準一, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  64. 母子保健情報と学校保健情報を連係した情報の活用に向けた研究 自治体・学校・教育委員会・医療機関等における情報連係の必要性・効果・期待に関する調査

    小原拓, 野田あおい, 上野史彦, 村上慶子, 石黒真美

    母子保健情報と学校保健情報を連係した情報の活用に向けた研究 令和元年度 総括・分担研究報告書(Web)　2020

  65. 母子保健情報と学校保健情報を連係した情報の活用に向けた研究 乳幼児・学童期における各健診項目について関連性のある項目の一覧作成

    小原拓, 野田あおい, 上野史彦, 村上慶子, 石黒真美, 大柳元

    母子保健情報と学校保健情報を連係した情報の活用に向けた研究 令和元年度 総括・分担研究報告書(Web)　2020

  66. 産後1年までのうつ症状の推移と心理社会的要因との関連:三世代コホート調査

    菊地紗耶, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大柳元, 大柳元, 小原拓, 小原拓, 小原拓, 小林奈津子, 小林奈津子, 菅原準一, 富田博秋, 富田博秋, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  67. 生存時間解析による妊娠高血圧腎症のリスク予測:三世代コホート調査

    大瀬戸恒志, 石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 大柳元, 大柳元, 菊谷昌浩, 菊谷昌浩, 目時弘仁, 目時弘仁, 菅原準一, 菅原準一, 菅原準一, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  68. 妊娠前BMIと各種妊娠アウトカムとの関連について-三世代コホート調査-

    黒田真帆, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大柳元, 大柳元, 大柳元, 菊谷昌浩, 菊谷昌浩, 菊谷昌浩, 目時弘仁, 目時弘仁, 目時弘仁, 小原拓, 小原拓, 小原拓, 菅原準一, 菅原準一, 菅原準一, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  69. 未成年の血圧値と血圧に関連する要因:三世代コホート調査

    石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大柳元, 大柳元, 大柳元, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  70. 三世代コホート調査:母子・学校保健情報の連係による身長・体重の胎生期~学童期と思春期間での相関の検討

    上野史彦, 小原拓, 村上慶子, 石黒真美, 野田あおい, 大柳元, 目時弘仁, 目時弘仁, 菅原準一, 黒川修行, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  71. 出生時体重と妊娠糖尿病との関連についての検討:三世代コホート調査

    大柳元, 大柳元, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　30th　2020

  72. 尿中ナトリウムカリウム比と血圧高値との関連:地域住民コホート調査

    小暮真奈, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 中谷直樹, 菊谷昌浩, 目時弘仁, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　30th　2020

  73. Bootstrap法およびPermutation法の応用による三世代家族の身長,体重,BMIの世代間関連の評価:三世代コホート調査

    臼崎琢磨, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 野田あおい, 野田あおい, 野田あおい, 上野史彦, 上野史彦, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

    日本衛生学雑誌(Web)　75　(Supplement)　2020

    ISSN： 1882-6482

  74. 妊婦における妊娠前からの葉酸サプリメントの摂取率および関連要因の検討:三世代コホート研究

    菊池大輔, 臼崎琢磨, 大柳元, 大柳元, 米沢祐大, 米沢祐大, 山下貴宏, 山下貴宏, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 小原拓, 小原拓

    日本疫学会学術総会講演集(Web)　30th　2020

  75. 【Evidence Update 2020 最新の薬物治療のエビデンスを付加的に利用する】エキスパートが注目する最新エビデンスをアップデート! 降圧薬

    菊池 大輔, 三浦 良祐, 小原 拓

    薬局　71　(1)　22-26　2020/01

    Publisher: (株)南山堂

    ISSN： 0044-0035

  76. Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. International-journal Peer-reviewed

    Takumi Hirata, Tomohiro Nakamura, Mana Kogure, Naho Tsuchiya, Akira Narita, Ken Miyagawa, Kotaro Nochioka, Akira Uruno, Taku Obara, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　23-29　2020/01

    DOI： 10.1038/s41440-019-0329-0 　

    ISSN： 0916-9636

  77. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. International-journal Peer-reviewed

    Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　62-71　2020/01

    DOI： 10.1038/s41440-019-0335-2 　

    ISSN： 0916-9636

  78. 大規模健診時血圧データに基づく加齢に伴う血圧推移に関する縦断解析

    佐藤 倫広, 村上 任尚, 小原 拓, 辰巳 友佳子, 高畠 恭介, 原 梓, 浅山 敬, 今井 潤, 菊谷 昌浩, 大久保 孝義, 目時 弘仁

    日本循環器病予防学会誌　54　(3)　163-170　2019/12

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  79. TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

    寳澤 篤, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 布施 昇男, 山本 雅之

    日本公衆衛生学会総会抄録集　78回　212-212　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  80. 6.3万人データ分譲に向けて 東北メディカル・メガバンク計画地域住民コホート調査

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 村上 慶子, 小原 拓, 中谷 直樹, 丹野 高三, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　212-212　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  81. 高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討 東北メディカル・メガバンク計画コホート調査の成果から

    小暮 真奈, 平田 匠, 土屋 菜歩, 中村 智洋, 宮川 健, 小清水 宏, 小原 拓, 目時 弘仁, 宇留野 晃, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　287-287　2019/10

    Publisher: (NPO)日本高血圧学会

  82. 非喫煙者における受動喫煙の有無と家庭高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 佐藤 倫広, 土屋 菜歩, 中村 智洋, 宇留野 晃, 小原 拓, 目時 弘仁, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　288-288　2019/10

    Publisher: (NPO)日本高血圧学会

  83. 本態性高血圧患者における治療前および降圧治療中の家庭血圧指標の予後予測能 HOMED-BP研究

    渡部 大介, 浅山 敬, 花澤 智大, 保坂 実樹, 佐藤 倫広, 安井 大策, 小原 拓, 井上 隆輔, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　42回　223-223　2019/10

    Publisher: (NPO)日本高血圧学会

  84. 【高血圧 地域包括ケアで薬立つ血圧管理の勘所】高血圧対応力を磨く10のClinical Question! 薬局での血圧測定の意義は何か

    小原 拓

    薬局　70　(10)　1919-1923　2019/09

    Publisher: (株)南山堂

    ISSN： 0044-0035

  85. 【高血圧 地域包括ケアで薬立つ血圧管理の勘所】高血圧の薬学的管理Clinical Evidence Synopsis 先行研究から明らかとなった薬剤師による介入の有効性

    石黒 真美, 小原 拓

    薬局　70　(10)　1955-1962　2019/09

    Publisher: (株)南山堂

    ISSN： 0044-0035

  86. 選ばれる薬局を目指して

    川田 哲, 小原 拓, 阿部 真也, 齋藤 真奈実, 川田 むつき, 佐藤 宏平, 野村 和彦, 吉町 昌子, 後藤 輝明

    社会薬学　38　(Suppl.)　88-88　2019/09

    Publisher: 日本社会薬学会

    ISSN： 0911-0585

    eISSN： 2188-2754

  87. Lenalidomide使用中の多発性骨髄腫患者におけるacetylsalicylic acidの使用状況 MDV analyzerを用いた診療データに基づく実態調査

    菊池 大輔, 小原 拓, 三浦 良祐, 高橋 庄太, 柏倉 正太, 岡田 浩司, 渡辺 善照

    医薬品情報学　21　(2)　79-86　2019/08

    Publisher: (一社)日本医薬品情報学会

    ISSN： 1345-1464

    eISSN： 1883-423X

    More details Close

    レナリドミド(LD)使用中の多発性骨髄腫患者におけるアスピリン(ASA)の使用状況について検討した。WEB版分析ツールであるMDV analyzerを用い、診療データに基づき後方視的に調査を実施した。最終解析対象となる多発性骨髄腫患者は7590名(男性3887名、女性3703名)であった。LD/デキサメタゾン(DEX)使用状況別に血栓塞栓症の有病割合を算出した結果、LD/DEX非使用群とLD/DEX併用群、DEX単独群とLD/DEX併用群との間にそれぞれ有意な差が認められた。LD/DEX併用群(1293名)における血栓塞栓症の有無とASA使用の有無に関して有意な差が認められた。LD/DEX併用群において、血栓塞栓症を有していない群1074名のうちASAを使用していたのは683名(63.6%)、血栓塞栓症を有している群219名のうちASAを使用していたのは184名(84.0%)であった。また、血栓塞栓症を有していない群において、性別とASA使用の有無、年齢の分布とASA使用の有無に有意な関連は認められなかった。

  88. 生活者からの質問相談内容から作成したOTC販売時の医薬品リスト利用状況調査

    玉田 麻利子, 阿部 真也, 小原 拓, 武藤 一敬, 野村 和彦, 吉町 昌子, 後藤 輝明

    日本医薬品情報学会総会・学術大会講演要旨集　22回　104-104　2019/06

    Publisher: (一社)日本医薬品情報学会

  89. 妊婦の推定糸球体ろ過量(eGFR)と妊娠高血圧症候群の関連について BOSHI研究

    菊地 ひかり, 奈良井 大輝, 佐々木 里美, 高畠 恭介, 中山 晋吾, 佐藤 倫広, 村上 任尚, 岩間 憲之, 石黒 真美, 小原 拓, 大久保 孝義, 今井 潤, 目時 弘仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　8回　198-198　2019/05

    Publisher: (NPO)日本高血圧学会

  90. 妊婦の推定糸球体ろ過量(eGFR)と妊娠高血圧症候群の関連について BOSHI研究

    菊地 ひかり, 奈良井 大輝, 佐々木 里美, 高畠 恭介, 中山 晋吾, 佐藤 倫広, 村上 任尚, 岩間 憲之, 石黒 真美, 小原 拓, 大久保 孝義, 今井 潤, 目時 弘仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　8回　198-198　2019/05

    Publisher: (NPO)日本高血圧学会

  91. 新規リスク因子(尿ナトカリ比高値・睡眠効率不良)の高血圧への集団寄与危険割合の検討

    平田匠, 平田匠, 中村智洋, 中村智洋, 小暮真奈, 小暮真奈, 宮川健, 小原拓, 小原拓, 中谷直樹, 中谷直樹, 宇留野晃, 宇留野晃, 菅原準一, 菅原準一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤

    日本循環器病予防学会誌　54　(2)　121-121　2019/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  92. 成人における客観的睡眠効率と高血圧有病率との関連(Association of Objective Sleep Efficiency with Prevalence of Hypertension in Adults)

    平田 匠, 中村 智洋, 小暮 真奈, 成田 暁, 宮川 健, 後岡 広太郎, 土屋 菜歩, 小原 拓, 中谷 直樹, 栗山 進一, 寳澤 篤

    日本循環器学会学術集会抄録集　83回　OJ22-4　2019/03

    Publisher: (一社)日本循環器学会

  93. JADERを用いた小児におけるシグナル検出の妥当性の検討

    酒井 隆全, 小原 拓, 吉田 真貴子, 田辺 公一, 大津 史子

    日本薬学会年会要旨集　139年会　(4)　177-177　2019/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  94. 我が国の小児を対象とした大規模バイオバンクとコホート研究 東北メディカル・メガバンクの三世代コホート調査の概要と収集試料・データの利活用

    栗山 進一, 小原 拓, 石黒 真美, 呉 繁夫

    日本小児科学会雑誌　123　(2)　159-159　2019/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  95. 配偶者の主観的健康観と自身の抑うつ症状との関連:東北メディカル・メガバンク計画・地域住民コホート調査

    中谷直樹, 土屋菜歩, 中谷久美, 成田暁, 平田匠, 中村智洋, 小暮真奈, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　29th　122 (WEB ONLY)　2019/01/30

  96. 三世代コホート調査参加児の来所センターと住所との関連の把握:小児の追跡調査実施戦略を考えるための検討

    小林朋子, 中村智洋, 小原拓, 寳澤篤, 栗山進一

    日本疫学会学術総会講演集(Web)　29th　2019

  97. Antihypertensives Prescribed for Pregnant Women in Japan: Prevalence and Timing Determined from a Database of Health Insurance Claims

    Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Keiko Miyakoda, Mami Ishikuro, Hirohito Metoki, Takayoshi Ohkubo, Junichi Sugawara, Nobuo Yaegashi, Manabu Akazawa, Shinichi Kuriyama, Nariyasu Mano

    Drug Safety　41　(11)　1168-1169　2018/11

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s40264-018-0719-2 　

  98. 妊娠期間中の飲酒と妊娠高血圧症候群リスクとの関連

    岩間 憲之, 田中 宏典, 目時 弘仁, 西郡 秀和, 水野 聖士, 高橋 史郎, 渡邉 善, 齋藤 昌利, 櫻井 香澄, 石黒 真美, 小原 拓, 龍田 希, 西島 維知子, 杉山 隆, 藤原 幾磨, 栗山 進一, 有馬 隆博, 仲井 邦彦, 八重樫 伸生

    日本妊娠高血圧学会雑誌　25　109-109　2018/11

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  99. 東日本大震災後のメンタルヘルス関連指標変化と家屋被害の関連

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 呉 繁夫, 大塚 耕太郎, 富田 博秋, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　252-252　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  100. 家屋の損壊の程度と頸動脈エコー内膜中膜肥厚の変化 地域住民コホート調査

    寳澤 篤, 中谷 久美, 平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 呉 繁夫

    日本公衆衛生学会総会抄録集　77回　345-345　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  101. 一般住民における尿Na/K比と腎機能障害への進行の関連 住民コホート調査

    良知 弘務, 土屋 菜歩, 平田 匠, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　345-345　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  102. 東日本大震災の被災地住民における平均歩数の変化 地域住民コホート調査

    中谷 直樹, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　209-209　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  103. 尿中ナトリウムカリウム比値と家庭血圧値の変化 地域住民コホート調査

    小暮 真奈, 中谷 直樹, 土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　215-215　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  104. 東日本大震災の被災地住民における家庭血圧値の変化 地域住民コホート調査

    中村 智洋, 中谷 直樹, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　218-218　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  105. 家屋損壊程度と骨梁面積率の変化量の関連 東北メディカル・メガバンク事業

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 平田 匠, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　253-253　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  106. 東日本大震災に伴う家屋被害の程度とHbA1c値の変化の関連 地域住民コホート調査

    平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　358-358　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  107. レセプトデータベースに基づく妊婦への降圧薬処方状況の評価

    石川 智史, 小原 拓, 都田 桂子, 石黒 真美, 目時 弘仁, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　41回　OE05-04　2018/09

    Publisher: (NPO)日本高血圧学会

  108. 疫学研究における妊婦の随時血圧と家庭血圧に関する検討 三世代コホート調査

    臼崎 琢磨, 石黒 真美, 小原 拓, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    日本高血圧学会総会プログラム・抄録集　41回　YIP-09　2018/09

    Publisher: (NPO)日本高血圧学会

  109. レセプトデータベースに基づく妊婦への降圧薬処方状況の評価

    石川 智史, 小原 拓, 都田 桂子, 石黒 真美, 目時 弘仁, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　41回　OE05-04　2018/09

    Publisher: (NPO)日本高血圧学会

  110. 身長、体重、BMIの世代間の関連 三世代コホート調査

    臼崎 琢磨, 石黒 真美, 小原 拓, 山中 千鶴, 永井 雅人, 松原 博子, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    東北公衆衛生学会誌　(67)　35-35　2018/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  111. Defined Daily Doseと比較した日本の降圧薬処方用量 レセプトデータに基づく検討

    佐藤 倫広, 村上 任尚, 小原 拓, 辰巳 友佳子, 高畠 恭介, 原 梓, 浅山 敬, 今井 潤, 大久保 孝義, 目時 弘仁

    日本医薬品情報学会総会・学術大会講演要旨集　21回　125-125　2018/06

    Publisher: (一社)日本医薬品情報学会

  112. 大規模健診時血圧データに基づくリアルワールドにおける降圧治療前後の血圧状況に関する前向き検討

    佐藤 倫広, 村上 任尚, 小原 拓, 辰巳 友佳子, 原 梓, 浅山 敬, 今井 潤, 大久保 孝義, 目時 弘仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　7回　218-218　2018/05

    Publisher: (NPO)日本高血圧学会

  113. 大規模健診時血圧データに基づくリアルワールドにおける降圧治療前後の血圧状況に関する前向き検討

    佐藤 倫広, 村上 任尚, 小原 拓, 辰巳 友佳子, 原 梓, 浅山 敬, 今井 潤, 大久保 孝義, 目時 弘仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　7回　218-218　2018/05

    Publisher: (NPO)日本高血圧学会

  114. 大規模健診時血圧データに基づく加齢に伴う健診時血圧の推移に関する検討

    佐藤 倫広, 村上 任尚, 小原 拓, 辰巳 友佳子, 高畠 恭介, 原 梓, 浅山 敬, 今井 潤, 大久保 孝義, 目時 弘仁

    日本循環器病予防学会誌　53　(2)　183-183　2018/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  115. レセプトデータを利用した小児ADHD患者における処方実態の把握

    吉田 真貴子, 小原 拓, 菊地 紗耶, 菊地 正史, 山口 浩明, 眞野 成康

    日本薬学会年会要旨集　138年会　(4)　185-185　2018/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  116. 出生体重と成人期の高血圧有病との関連:東北メディカル・メガバンク計画地域住民コホート調査

    石黒真美, 小原拓, 目時弘仁, 目時弘仁, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 菅原準一, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一

    日本疫学会学術総会講演集(Web)　28th　118 (WEB ONLY)　2018/02/01

  117. 周辺環境へのアクセシビリティと産後6ヶ月時点の抑うつ症状との関連:三世代コホート調査

    永井雅人, 水野聖士, 小暮真奈, 石黒真美, 山中千鶴, 松原博子, 小原拓, 小原拓, 菊谷昌浩, 目時弘仁, 目時弘仁, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　28th　85 (WEB ONLY)　2018/02/01

  118. 抗がん薬による手足症候群発現時期に関する検討

    小林美奈子, 土屋雅美, 土屋雅美, 菊地正史, 小原拓, 木皿重樹, 高村千津子, 眞野成康, 眞野成康

    日本臨床腫瘍薬学会学術大会講演要旨集　2018　2018

  119. 降圧治療中患者におけるHome Arterial Stiffness Index(HASI)の臨床的有用性の評価

    小原拓, 菊谷昌浩, 佐藤倫広, 井上隆輔, 浅山敬, 目時弘仁, 目時弘仁, 今井潤, 大久保孝義

    日本高血圧学会総会プログラム・抄録集　40th　446-446　2017/10/20

    Publisher: (NPO)日本高血圧学会

  120. 尿中ナトリウムカリウム比と高血圧有病リスクとの関連 地域住民コホート調査

    小暮 真奈, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 清元 秀泰, 菊谷 昌浩, 目時 弘仁, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　291-291　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  121. 地域住民コホート調査における年齢別の中心血圧分布

    菊谷 昌浩, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 目時 弘仁, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　293-293　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  122. 東日本大震災後の被災地における降圧治療中患者の血圧管理 東北メディカル・メガバンク地域住民コホート調査

    小原 拓, 菊谷 昌浩, 石黒 真美, 目時 弘仁, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　40回　407-407　2017/10

    Publisher: (NPO)日本高血圧学会

  123. 検診時血圧と家庭血圧の男女別年齢階級別平均値 東北メディカル・メガバンク計画地域住民コホート調査

    目時 弘仁, 佐藤 倫広, 村上 任尚, 石黒 真美, 小原 拓, 菊谷 昌浩, 清元 秀泰, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　40回　411-411　2017/10

    Publisher: (NPO)日本高血圧学会

  124. 妊婦に対する降圧薬処方の実態 レセプトデータに基づく検討

    小原 拓, 目時 弘仁, 佐藤 倫広, 石黒 真美, 菊谷 昌浩, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　40回　413-413　2017/10

    Publisher: (NPO)日本高血圧学会

  125. 受動喫煙と妊娠期間中の血圧推移 BOSHI研究

    目時 弘仁, 佐藤 倫広, 村上 任尚, 田中 宏典, 石黒 真美, 小原 拓, 八重樫 伸生, 星 和彦, 今井 潤, 大久保 孝義

    日本アルコール・薬物医学会雑誌　52　(4)　238-238　2017/08

    Publisher: 日本アルコール・アディクション医学会

    ISSN： 1341-8963

  126. 東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

    宮下 真子, 菊谷 昌浩, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 佐藤 ゆき, 石黒 真美, 小原 拓, 目時 弘仁, 栗山 進一

    東北公衆衛生学会誌　(66)　31-31　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  127. 東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

    宮下 真子, 菊谷 昌浩, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 佐藤 ゆき, 石黒 真美, 小原 拓, 目時 弘仁, 栗山 進一

    東北公衆衛生学会誌　(66)　31-31　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  128. 東日本大震災後の宮城県における小中学生の気管支喘息と湿疹の有症率について 東北大学東北メディカル・メガバンク機構地域子ども長期健康調査より

    宮下 真子, 菊谷 昌浩, 田中 彰二, 山中 千鶴, 佐藤 ゆき, 水野 聖士, 石黒 真美, 小原 拓, 目時 弘仁, 成田 暁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌　(49)　14-14　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  129. 東北メディカル・メガバンク事業 地域住民コホート(宮城県)の進捗とこれまでの成果で見えてきたこと

    寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 菊谷 昌浩, 小原 拓, 石黒 真美, 佐藤 ゆき, 山中 千鶴, 宮下 真子, 目時 弘仁, 栗山 進一, 辻 一郎

    宮城県公衆衛生学会会誌　(49)　17-17　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  130. Current Status and Issues for the Use of the Spontaneous Reporting System of Adverse Drug Reaction in Japan

    48　(3)　163-169　2017

    Publisher: 日本公定書協会

    ISSN： 1884-6076

  131. Questionnaire Survey on Collection, Management, and Report of Adverse Drug Reactions in a Hospital

    53　(1)　73-77　2017/01

    Publisher: 日本病院薬剤師会

    ISSN： 1341-8815

  132. がん専門薬剤師による副作用等情報の集積とJADERの評価

    土屋雅美, 土屋雅美, 小原拓, 眞野成康, 眞野成康, 高村千津子

    日本医療薬学会年会講演要旨集(Web)　27　2017

    ISSN： 2424-2470

  133. 医薬品・医療機器等安全性情報報告制度の活用に関する現状と課題 (特集 副作用情報を収集・活用する!)

    小原 拓, 眞野 成康

    月刊薬事 = The pharmaceuticals monthly　58　(13)　2863-2868　2016/10

    Publisher: じほう

    ISSN： 0016-5980

  134. 家庭血圧の季節変動と脳心血管イベントとの関連:HOMED‐BP研究

    花澤智大, 花澤智大, 浅山敬, 浅山敬, 渡部大介, 渡部大介, 田辺杏由美, 佐藤倫広, 井上隆輔, 小原拓, 小原拓, 菊谷昌浩, 野村恭子, 目時弘仁, 大久保孝義, 今井潤

    日本高血圧学会総会プログラム・抄録集　39th　387-387　2016/09/30

    Publisher: (NPO)日本高血圧学会

  135. 一般地域住民における異なる時間定義に基づく夜間降圧度と脳心血管長期予後との関連―大迫研究―

    佐藤倫広, 浅山敬, 浅山敬, 菊谷昌浩, 井上隆輔, 坪田恵, 小原拓, 小原拓, 村上慶子, 松田彩子, 村上任尚, 野村恭子, 目時弘仁, 今井潤, 大久保孝義

    日本高血圧学会総会プログラム・抄録集　39th　319-319　2016/09/30

    Publisher: (NPO)日本高血圧学会

  136. わが国の外来患者における家庭血圧測定の現状:10年の変遷

    小原拓, 小原拓, 阿部真也, 吉町昌子, 佐藤倫広, 大久保孝義, 眞野成康, 後藤輝明, 今井潤

    日本高血圧学会総会プログラム・抄録集　39th　426-426　2016/09/30

    Publisher: (NPO)日本高血圧学会

  137. さまざまな集団における高血圧の疫学(小児、若年、妊娠、超高齢者等) 妊娠中の高血圧

    目時 弘仁, 佐藤 倫広, 村上 任尚, 岩間 憲之, 石黒 真美, 小原 拓, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　39回　237-237　2016/09

    Publisher: (NPO)日本高血圧学会

  138. Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: The BOSHI study

    Noriyuki Iwama, The BOSHI Study Group, Hirohito Metoki, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Katsuyo Yagihashi, Hidekazu Nishigori, Takashi Sugiyama, Junichi Sugawara, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai, Kohei Tanaka, Kunihiko Okamura, Kei Asayama, Ryusuke Inoue, Rie Tsuchida, Azusa Hara, Takuo Hirose, Takeshi Kobayashi, Kenta Gonokami, Takanao Hashimoto, Yumiko Watanabe, Misato Nishimura, Maiko Kawaguchi, Yurie Sato, Minako Hoshikawa, Ayano Sasaki, Kasumi Sakurai, Michihiro Sato, Konomi Akutsu, Mami Yamamoto, Aya Shiraishi, Miki Hosaka, Ikuo Tachibana, Maki Omura, Mikiko Ishikawa, Yoshimi Fujii, Hidemi Kobayashi, Kazuyuki Akaishi, Yuko Kikuchi, Kei Tate, Chieko Koishi, Saori Sugawara, Junko Saitou, Hiromi Sasaki, Tomoko Suzuki, Junko Takahashi, Yoko Narita, Satoko Shigihara, Hideko Tada, Yumi Hamada, Nozomi Satou, Nami Satou, Setsuko Sai, Nana Atsumi, Naoko Sekine, Yukari Ueno, Yu Itou, Yukie Obara, Nami Onodera, Asako Sato, Youko Iwasa, Mamiko Abe, Yukari Kido, Risako Komuro, Yukiko Nakamura, Marie Watanabe, Chikako Matsumoto, Koto Oyama, Aya Takahashi, Michiko Kojima, Miyuki Abe, Mariko Sane, Mana Takahashi, Kana Sugata Miho Igari, Haruhi Sasaki, Mizuki Kobayashi, Aya Kikuchi, Risa Yamamoto, Akiho Goto, Eri Yamauchi, Mika Chiba, Sakiko Ota, Hiromi Ishikawa, Akemi Sasaki, Tomoko Kawamura, Hiroko Hiji, Misaki Kishinami, Yurie Kowata, Eiko Yamauchi, Yasuko Takahashi, Naho Sato

    Hypertension Research　39　(3)　151-157　2016/03/01

    Publisher: Japanese Society of Hypertension

    DOI： 10.1038/hr.2015.108 　

    ISSN： 1348-4214 0916-9636

  139. 震災関連要因と慢性疾患の治療中断の関連:地域住民コホート調査

    中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 菊谷昌浩, 小原拓, 丹野高三, 佐々木亮平, 坂田清美, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    Journal of Epidemiology (Web)　26　(Supplement 1)　2016

    ISSN： 1349-9092

  140. Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study

    Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Noriyuki Iwama, Mikiko Katagiri, Hidekazu Nishigori, Yoko Narikawa, Katsuyo Yagihashi, Masahiro Kikuya, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

    HYPERTENSION RESEARCH　38　(11)　770-775　2015/11

    DOI： 10.1038/hr.2015.97 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  141. 乳幼児期の身長SDスコアの変化

    田中 敏章, 磯島 豪, 横谷 進, 加藤 則子, 山縣 然太朗, 横道 洋司, 田中 総一郎, 呉 繁夫, 松原 博子, 小原 拓, 石黒 真美, 佐藤 ゆき, 目時 裕仁, 菊谷 昌浩, 栗山 進一, 千田 勝一, 小野 敦史, 細谷 光亮

    日本成長学会雑誌　21　(2)　94-94　2015/10

    Publisher: 日本成長学会

    ISSN： 1880-022X

  142. Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide

    Miki Hosaka, Hirohito Metoki, Michihiro Satoh, Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Taku Obara, Takuo Hirose, Yutaka Imai

    HYPERTENSION RESEARCH　38　(10)　701-707　2015/10

    DOI： 10.1038/hr.2015.64 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  143. 東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

    寳澤 篤, 清元 秀泰, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小原 拓, 目時 弘仁, 丹野 高三, 中谷 純, 菊谷 昌浩, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之

    日本公衆衛生学会総会抄録集　74回　260-260　2015/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  144. 妊娠前・妊娠中・出産後における血圧管理 降圧目標と薬剤選択 妊娠初期の血圧管理・降圧薬の選択

    目時 弘仁, 石黒 真美, 佐藤 倫広, 小原 拓, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　38回　312-312　2015/10

    Publisher: (NPO)日本高血圧学会

  145. 東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

    寳澤 篤, 清元 秀泰, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小原 拓, 目時 弘仁, 丹野 高三, 中谷 純, 菊谷 昌浩, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之

    日本公衆衛生学会総会抄録集　74回　260-260　2015/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  146. 東日本大震災時の保険薬局の特例措置に関する認識と情報収集方法

    我妻 恭行, 佐藤 倫広, 小原 拓

    日本薬剤師会雑誌 = Journal of the Japan Pharmaceutical Association　67　(8)　1153-1155　2015/08

    Publisher: 日本薬剤師会

    ISSN： 0369-674X

  147. Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study

    Michihiro Satoh, Miki Hosaka, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

    JOURNAL OF HYPERTENSION　33　(8)　1536-1541　2015/08

    DOI： 10.1097/HJH.0000000000000570 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  148. Salt intake and the validity of a salt intake assessment system based on a 24-h dietary recall method in pregnant Japanese women

    Michihiro Satoh, Yumi Tanno, Miki Hosaka, Hirohito Metoki, Taku Obara, Kei Asayama, Kazuhiko Hoshi, Masakuni Suzuki, Nariyasu Mano, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　37　(6)　459-462　2015/08

    DOI： 10.3109/10641963.2015.1057832 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  149. Differences between clinic and home blood pressure measurements during pregnancy

    Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Nobuo Yaegashi, Shinichi Kuriyama, Yutaka Imai

    JOURNAL OF HYPERTENSION　33　(7)　1492-1493　2015/07

    DOI： 10.1097/HJH.0000000000000608 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  150. Differential effects of angiotensin II receptor blocker and losartan/hydrochlorothiazide combination on central blood pressure and augmentation index International-journal

    Hirohito Metoki, Hirohito Metoki, Taku Obara, Taku Obara, Taku Obara, Taku Obara, Kei Asayama, Kei Asayama, Kei Asayama, Michihiro Satoh, Michihiro Satoh, Miki Hosaka, Noha Elnagar, Yoshinori Miyawaki, Iwao Kojima, Takayoshi Ohkubo, Takayoshi Ohkubo, Takayoshi Ohkubo, Yutaka Imai, Yutaka Imai, Ryusuke Inoue, Junichiro Hashimoto, Masahiro Kikuya, Kazuhito Totsune, Motoya Nakagawa, Shigemichi Tanaka, Kotaro Nakamura, Nanako Hiwatari, Mutsuo Watanabe, Kenji Ito, Ruriko Mori, Hiroki Hoshi, Shuichi Sasaki, Daisuke Nakayama, Kouzou Ohta, Hiroshi Shishido, Youkou Emura, Hideo Odaka, Norihisa Kumasaka, Kazuteru Ohhira, Kuninobu Nihei, Kiyoto Ishibashi, Mitsutoshi Kato, Kiyoshi Uchiba, Masaaki Miyakawa, Hisao Mori, Takao Sugawara, Nobuhisa Yamada, Naoto Yagi, Yutaka Hatori, Tomoko Gomi, Toshio Ikeda, Takeshi Koitabashi, Shuji Arima, Masao Hiwatari

    Clinical and Experimental Hypertension　37　(4)　294-302　2015/07/01

    DOI： 10.3109/10641963.2014.960972 　

    ISSN： 1064-1963

  151. Correlation Between the Great East Japan Earthquake and Postpartum Depression: A Study in Miyako, Iwate, Japan

    Hidekazu Nishigori, Michiho Sasaki, Taku Obara, Toshie Nishigori, Mami Ishikuro, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama, Akira Hosoyachi, Nobuo Yaegashi, Takashi Kobayashi, Noboru Yoshizumi

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　9　(3)　307-312　2015/06

    DOI： 10.1017/dmp.2015.51 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  152. 東日本大震災後の小中学生の保護者が抱く子どもの不安と悩みの特徴 宮城県南部の実態調査から

    佐藤 ゆき, 菊谷 昌浩, 宮下 真子, 山中 千鶴, 石黒 真美, 小原 拓, 目時 弘仁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 寳澤 篤, 辻 一郎, 呉 繁夫, 八重樫 伸生, 栗山 進一

    小児保健研究　74　(講演集)　139-139　2015/05

    Publisher: (公社)日本小児保健協会

    ISSN： 0037-4113

  153. Home Blood Pressure Had a Stronger Predictive Power for Infant Birth Weight Than Clinic Blood Pressure: The Boshi Study. Peer-reviewed

    Noriyuki Iwama, Hirohito Metoki, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Katsuyo Yagihashi, Hidekazu Nishigori, Takashi Sugiyama, Junichi Sugawara, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

    REPRODUCTIVE SCIENCES　22　383A-383A　2015/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  154. 果物・野菜・海藻摂取とすい臓がん罹患リスク:大崎国保コホート研究

    SHIGIHARA MICHIKO, OHARA TAKU, NAGAI MASATO, SUGAHARA YUMI, WATANABE TAKASHI, KAKIZAKI MASAKO, NISHINO YOSHIKAZU, KURIYAMA SHIN'ICHI, TSUJI ICHIRO

    宮城県公衆衛生学会会誌　(47)　6-6　2015/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  155. 緑茶成分摂取量と動脈硬化関連指標との関連 掛川コホート研究

    五十嵐 祐子, 小原 拓, 石黒 真美, 鴫原 美智子, 都田 桂子, 目時 弘仁, 菊谷 昌浩, 栗山 進一

    宮城県公衆衛生学会会誌　(47)　5-5　2015/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  156. Blood Pressure and Heart Rate Among Pregnant Women Before and After the Great East Japan Earthquake (11, March, 2011) in the BOSHI Study. Peer-reviewed

    Hirohito Metoki, Noriyuki Iwama, Zen Watanabe, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Kiyoshi Itoh, Kazuhiko Hoshi, Masakuni Suzuki, Michihiro Satoh, Nobuo Yaegashi, Yutaka Imai

    REPRODUCTIVE SCIENCES　22　385A-385A　2015/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  157. Association of Aldosterone-to-Renin Ratio With Hypertension Differs by Sodium Intake: The Ohasama Study

    Michihiro Satoh, Masahiro Kikuya, Miki Hosaka, Kei Asayama, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Takefumi Mori, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

    AMERICAN JOURNAL OF HYPERTENSION　28　(2)　208-215　2015/02

    DOI： 10.1093/ajh/hpu115 　

    ISSN： 0895-7061

    eISSN： 1941-7225

  158. P1201-22-PM 向精神薬服用妊婦に対して行った授乳に関する情報提供の現状(妊婦・授乳婦,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

    八島 一史, 菊地 紗耶, 小林 奈津子, 久道 周彦, 眞野 成康, 中川 直人, 小原 拓, 千葉 和美, 山本 美由紀, 西郡 秀和, 加藤 佳子, 松浦 正樹, 秋山 志津子

    日本医療薬学会年会講演要旨集　25　(0)　466-466　2015

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.25.0_466_1 　

  159. 医薬品リスク管理計画に関する薬剤師の認識

    山口浩明, 小原拓, 佐藤倫広, 大久保孝義, 村井ユリ子, 井関健, 眞野成康

    日本医薬品情報学会総会・学術大会講演要旨集　17th　112-112　2014/07

    Publisher: (一社)日本医薬品情報学会

  160. 妊娠中の医薬品使用と児の先天奇形との関連 レセプトデータに基づく検討

    小原 拓, 佐藤 倫広, 西郡 秀和, 目時 弘仁, 大久保 孝義, 赤沢 学, 八重樫 伸生, 栗山 進一, 眞野 成康

    日本医薬品情報学会総会・学術大会講演要旨集　17回　81-81　2014/07

    Publisher: (一社)日本医薬品情報学会

  161. 地域子ども長期健康調査のこころとからだの支援

    山中 千鶴, 宮下 真子, 成川 洋子, 石黒 真美, 小原 拓, 目時 弘仁, 菊谷 昌浩, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌　(46)　4-4　2014/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  162. 東北メディカル・メガバンク事業―地域住民コホート調査に関する経過報告

    寶澤篤, 寶澤篤, 寶澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之

    J Epidemiol　24　(Supplement 1)　67　2014/01/23

    ISSN： 0917-5040

  163. 東北メディカル・メガバンク事業―三世代コホート調査に関する経過報告

    目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生

    J Epidemiol　24　(Supplement 1)　67　2014/01/23

    ISSN： 0917-5040

  164. 東北メディカル・メガバンク事業-地域子ども長期健康調査事業の進捗に関する経過報告

    菊谷昌浩, 成川洋子, 石黒真美, 小原拓, 目時弘仁, 中村智洋, 中谷直樹, 寳澤篤, 長神風二, 鈴木洋一, 富田博秋, 辻一郎, 栗山進一, 山本雅之, 菊谷昌浩, 成川洋子, 石黒真美, 小原拓, 目時弘仁, 中村智洋, 中谷直樹, 寳澤篤, 長神風二, 鈴木洋一, 富田博秋, 辻一郎, 栗山進一, 山本雅之, 富田博秋, 栗山進一

    Journal of Epidemiology　24　(Supplement 1)　2014

    ISSN： 0917-5040

  165. 東北メディカル・メガバンク事業 三世代コホート調査の進捗について

    目時 弘仁, 石黒 真美, 小原 拓, 佐藤 ゆき, 菊谷 昌浩, 栗山 進一, 寳澤 篤, 大隅 典子, 清元 秀泰, 菅原 準一, 鈴木 洋一, 冨永 悌二, 布施 昇男, 峯岸 直子, 辻 一郎, 呉 繁夫, 八重樫 伸生, 山本 雅之

    DOHaD研究　3　(1)　46-46　2014

    Publisher: 日本DOHaD研究会

    ISSN： 2187-2597

    More details Close

    第3回日本DOHaD研究会学術集会 抄録集 【ポスター発表】

  166. レセプトデータに基づく妊娠中の医薬品使用と児の先天奇形との関連に関する検討

    小原 拓, 西郡 秀和, 目時 弘仁, 眞野 成康, 八重樫 伸生, 栗山 進一

    DOHaD研究　3　(1)　58-58　2014

    Publisher: 日本DOHaD研究会

    ISSN： 2187-2597

    More details Close

    第3回日本DOHaD研究会学術集会 抄録集 【ポスター発表】

  167. Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study. International-journal

    Kei Kamide, Kei Asayama, Tomohiro Katsuya, Takayoshi Ohkubo, Takuo Hirose, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Hironori Hanada, Lutgarde Thijs, Tatiana Kuznetsova, Yuichi Noguchi, Ken Sugimoto, Mitsuru Ohishi, Shigeto Morimoto, Takeshi Nakahashi, Shin Takiuchi, Toshihiko Ishimitsu, Takuya Tsuchihashi, Masayoshi Soma, Jitsuo Higaki, Hideo Matsuura, Tatsuo Shinagawa, Toshiyuki Sasaguri, Tetsuro Miki, Kazuo Takeda, Kazuaki Shimamoto, Michio Ueno, Naohisa Hosomi, Jyouji Kato, Norio Komai, Shunichi Kojima, Kazuhiro Sase, Toshiyuki Miyata, Hitonobu Tomoike, Yuhei Kawano, Toshio Ogihara, Hiromi Rakugi, Jan A Staessen, Yutaka Imai

    Pharmacogenomics　14　(14)　1709-21　2013/11

    DOI： 10.2217/pgs.13.161 　

    ISSN： 1462-2416

  168. 日-P1-006 一般地域住民におけるセルフメディケーションに関する実態調査(OTC・セルフメディケーション,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

    岩森 紗希, 松本 章裕, 佐藤 倫広, 原 梓, 菊谷 昌浩, 小原 拓, 目時 弘仁, 廣瀬 卓男, 井上 隆輔, 浅山 敬, 高橋 信行, 眞野 成康, 佐藤 博, 今井 潤, 大久保 孝義

    日本医療薬学会年会講演要旨集　23　354-354　2013/08/28

    Publisher: 日本医療薬学会

  169. 土-9-O11-21 小児におけるインフルエンザワクチン接種の有効性評価(感染制御(その他)2,一般演題(口頭)11,再興、再考、創ろう最高の医療の未来)

    小原 拓, 島崎 信次郎, 金子 健二, 福田 純, 中村 泰之, 眞野 成康, 栗山 進一, 八木 直人

    日本医療薬学会年会講演要旨集　23　216-216　2013/08/28

    Publisher: 日本医療薬学会

  170. 土-11-O22-19 保険薬局薬剤師における遺伝薬理に関する認識調査(使用状況調査・意識調査1,一般演題(口頭)22,再興、再考、創ろう最高の医療の未来)

    小原 拓, 阿部 真也, 佐藤 倫広, 吉町 昌子, 後藤 輝明

    日本医療薬学会年会講演要旨集　23　227-227　2013/08/28

    Publisher: 日本医療薬学会

  171. 土-11-O22-18 薬剤師における後発医薬品に関する認識の変遷(使用状況調査・意識調査1,一般演題(口頭)22,再興、再考、創ろう最高の医療の未来)

    佐藤 倫広, 小原 拓, 高橋 則男, 猪狩 有紀恵, 眞野 成康, 早坂 正孝, 高橋 將喜, 北村 哲治

    日本医療薬学会年会講演要旨集　23　227-227　2013/08/28

    Publisher: 日本医療薬学会

  172. 日-8-O25-01 薬剤師における後発医薬品に関する認識の変遷(ジェネリック医薬品、有害事象・副作用,一般演題(口頭)25,再興、再考、創ろう最高の医療の未来)

    佐藤 倫広, 小原 拓, 高橋 則男, 猪狩 有紀恵, 眞野 成康, 早坂 正孝, 高橋 將喜, 鎌田 裕, 北村 哲治

    日本医療薬学会年会講演要旨集　23　230-230　2013/08/28

    Publisher: 日本医療薬学会

  173. 日-P4-609 保険薬局薬剤師における家庭血圧測定に関する認識(薬物療法(その他),ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

    山口 浩, 小原 拓, 佐藤 倫広, 阿部 真也, 吉町 昌子, 今井 潤, 後藤 輝明

    日本医療薬学会年会講演要旨集　23　452-452　2013/08/28

    Publisher: 日本医療薬学会

  174. 日-P2-319 治療中高血圧患者の高血圧管理における保険調剤薬局の関与 : J-HOME-Morning研究(治療・臨床試験,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

    小原 拓, 小林 由香, 池田 うらら, 保坂 実樹, 佐藤 倫広, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 大久保 孝義, 眞野 成康, 栗山 進一, 今井 潤

    日本医療薬学会年会講演要旨集　23　405-405　2013/08/28

    Publisher: 日本医療薬学会

  175. 日-P2-303 東日本大震災時の保険薬局の対応に関するアンケート調査(災害医療,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

    我妻 恭行, 小原 拓, 佐藤 倫広, 井筒 隆宏, 佐々木 孝雄, 鈴木 常義

    日本医療薬学会年会講演要旨集　23　402-402　2013/08/28

    Publisher: 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_402_5 　

  176. The reason why home blood pressure measurements are preferred over clinic or ambulatory blood pressure in Japan

    Yutaka Imai, Taku Obara, Kei Asamaya, Takayoshi Ohkubo

    HYPERTENSION RESEARCH　36　(8)　661-672　2013/08

    DOI： 10.1038/hr.2013.38 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  177. 妊婦における薬剤の使用に関する疫学調査

    小原 拓, 石黒 真美, 目時 弘仁, 菊谷 昌浩, 栗山 進一, 西郡 秀和, 八重樫 伸生, 大久保 孝義, 眞野 成康

    宮城県公衆衛生学会会誌　(45)　6-6　2013/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  178. 東北メディカル・メガバンクにおける地域子どもコホート事業について

    菊谷 昌浩, 石黒 真美, 小原 拓, 目時 弘仁, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌　(45)　10-10　2013/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  179. 東北メディカル・メガバンク事業 地域コホート計画について

    寳澤 篤, 菊谷 昌浩, 目時 弘仁, 小原 拓, 石黒 真美, 栗山 進一, 辻 一郎

    宮城県公衆衛生学会会誌　(45)　7-7　2013/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  180. Breastfeeding leads to lower blood pressure in 7-year-old Japanese children: Tohoku Study of Child Development

    Miki Hosaka, Kei Asayama, Jan A Staessen, Takayoshi Ohkubo, Katsuhisa Hayashi, Nozomi Tatsuta, Naoyuki Kurokawa, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Kunihiko Nakai, Yutaka Imai, Hiroshi Satoh

    Hypertension Research　36　(2)　117-122　2013/02

    DOI： 10.1038/hr.2012.128 　

    ISSN： 0916-9636 1348-4214

  181. 土-9-O12-30 レセプトデータに基づく妊娠中の抗菌薬処方状況の把握に関する研究(栄養管理・NST、妊婦・授乳婦,一般演題(口頭)12,再興、再考、創ろう最高の医療の未来)

    堀川 いずみ, 小原 拓, 目時 弘仁, 大久保 孝義, 八重樫 伸生, 眞野 成康, 佐藤 博, 栗山 進一

    日本医療薬学会年会講演要旨集　23　(0)　217-217　2013

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_217_5 　

  182. 土-11-O20-10 小児の広汎性発達障害患者における処方推移 : レセプトデータに基づく検討(精神科領域2,一般演題(口頭)20,再興、再考、創ろう最高の医療の未来)

    佐藤 倫広, 栗山 進一, 小原 拓, 大場 延浩, 森川 和彦, 石黒 真美, 目時 弘仁, 西郡 秀和, 菊谷 昌浩, 眞野 成康

    日本医療薬学会年会講演要旨集　23　(0)　225-225　2013

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_225_5 　

  183. 土-P1-001 東北大学病院における能動的情報提供のための院内広報サイトの構築(一般演題 ポスター発表,医療情報システム,再興、再考、創ろう最高の医療の未来)

    前川 麻央, 眞野 成康, 草場 美津江, 小原 拓, 尾崎 芙実, 中川 直人, 佐藤 真由美, 久道 周彦, 松浦 正樹, 我妻 恭行

    日本医療薬学会年会講演要旨集　23　(0)　252-252　2013

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_252_1 　

  184. 土-P1-019 東日本大震災後に当院職員が受けた薬に関連する問い合わせに関する調査(一般演題 ポスター発表,医薬品情報・データベース,再興、再考、創ろう最高の医療の未来)

    吉中 千佳, 小原 拓, 草場 美津江, 松浦 正樹, 眞野 成康

    日本医療薬学会年会講演要旨集　23　(0)　255-255　2013

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_255_1 　

  185. 土-P1-029 病院薬剤師の医薬品安全性評価に関する認識および実践に関する調査(一般演題 ポスター発表,使用状況調査・意識調査,再興、再考、創ろう最高の医療の未来)

    飯田 優太郎, 松浦 正樹, 佐藤 真由美, 眞野 成康, 小原 拓, 尾崎 芙実, 高田 紀子, 鈴木 理紗子, 佐藤 倫広, 青木 良子, 天沼 喜美子, 大久保 孝義

    日本医療薬学会年会講演要旨集　23　(0)　256-256　2013

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_256_5 　

  186. 日-P3-500 授乳と薬剤使用に関する問い合わせ内容の調査(妊婦・授乳婦,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

    尾崎 芙実, 佐賀 利英, 佐藤 真由美, 久道 周彦, 松浦 正樹, 眞野 成康, 小原 拓, 前川 真央, 吉中 千佳, 草場 美津江, 中川 直人, 飯田 優太郎, 鈴木 文子, 島田 美樹

    日本医療薬学会年会講演要旨集　23　(0)　434-434　2013

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_434_5 　

  187. 日-P3-503 妊婦に対する気管支喘息治療薬の処方状況の把握に関する研究(妊婦・授乳婦,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

    保坂 実樹, 小原 拓, 目時 弘仁, 佐藤 倫広, 大久保 孝義, 八重樫 伸生, 眞野 成康, 栗山 進一

    日本医療薬学会年会講演要旨集　23　(0)　435-435　2013

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_435_2 　

  188. Blood pressure measured in the clinic and at home during pregnancy among nulliparous and multiparous women: The BOSHI study

    Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Mami Yamamoto, Konomi Akutsu, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Katsuyo Yagihashi, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

    American Journal of Hypertension　26　(1)　141-148　2013/01

    DOI： 10.1093/ajh/hps002 　

    ISSN： 0895-7061 1941-7225

  189. Home blood pressure variability as cardiovascular risk factor in the population of ohasama

    Kei Asayama, Masahiro Kikuya, Rudolph Schutte, Lutgarde Thijs, Miki Hosaka, Michihiro Satoh, Azusa Hara, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Takuo Hirose, Takayoshi Ohkubo, Jan A. Staessen, Yutaka Imai

    Hypertension　61　(1)　61-69　2013/01

    DOI： 10.1161/HYPERTENSIONAHA.111.00138 　

    ISSN： 0194-911X 1524-4563

  190. Change of the management of treated hypertensive patients with or without diabetes in Japan

    Taku Obara, Takayoshi Ohkubo, Kazuki Ishikura, Taku Shibamiya, Urara Ikeda, Hirohito Metoki, Masahiro Kikuya, Nariyasu Mano, Shinichi Kuriyama, Yutaka Imai

    Clinical and Experimental Hypertension　35　(2)　79-86　2013

    DOI： 10.3109/10641963.2012.732640 　

    ISSN： 1064-1963 1525-6006

  191. Associations between visit-to-visit variability in blood pressure measured in the office and antihypertensive drugs: The J-HOME-Morning Study

    Taku Obara, Masahiro Kikuya, Yuka Kobayashi, Kazuki Ishikura, Urara Ikeda, Mami Ishikuro, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai

    Clinical and Experimental Hypertension　35　(4)　285-290　2013

    DOI： 10.3109/10641963.2013.780070 　

    ISSN： 1064-1963 1525-6006

  192. Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

    Kei Asayama, Takayoshi Ohkubo, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Masahiro Kikuya, Lutgarde Thijs, Jan A Staessen, Yutaka Imai

    Hypertension Research　35　(11)　1102-1110　2012/11

    DOI： 10.1038/hr.2012.125 　

    ISSN： 0916-9636 1348-4214

  193. Pharmacists' awareness and attitude toward blood pressure measurement at home and in the pharmacy in Japan

    Taku Obara, Takayoshi Ohkubo, Koji Tanaka, Michihiro Satoh, Kazuki Ishikura, Mitsuru Kobayashi, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Yuriko Murai, Nariyasu Mano, Sentaro Oide, Yutaka Imai

    Clinical and Experimental Hypertension　34　(6)　447-455　2012/10

    DOI： 10.3109/10641963.2012.666599 　

    ISSN： 1064-1963 1525-6006

  194. 新生児の血圧分布に関する研究 BOSHI 新生児研究

    井上 隆輔, 目時 弘仁, 大久保 孝義, 小原 拓, 菊谷 昌浩, 多田 秀子, 八木橋 香津代, 田中 耕平, 星 和彦, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　35回　410-410　2012/09

    Publisher: (NPO)日本高血圧学会

  195. 左室肥大と家庭血圧に基づく治療抵抗性高血圧との関連 J-HOME-Morning研究

    小林 由香, 小原 拓, 大久保 孝義, 菊谷 昌浩, 井上 隆輔, 目時 弘仁, 池田 うらら, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集　35回　411-411　2012/09

    Publisher: (NPO)日本高血圧学会

  196. 一般住民における血漿アルドステロン濃度/血漿レニン活性比(ARR)と高血圧発症の関連 大迫研究

    佐藤 倫広, 菊谷 昌浩, 大久保 孝義, 森 建文, 宇津木 恵, 田, 目時 弘仁, 廣瀬 卓男, 原 梓, 小原 拓, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 今井 潤

    日本高血圧学会総会プログラム・抄録集　35回　394-394　2012/09

    Publisher: (NPO)日本高血圧学会

  197. 同居家族の喫煙は脳卒中発症の危険因子である 大迫研究

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 関 真美, 浅山 敬, 目時 弘仁, 小原 拓, 廣瀬 卓男, 原 梓, 橋本 貴尚, 佐藤 倫広, 星 晴久, 戸恒 和人, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集　35回　400-400　2012/09

    Publisher: (NPO)日本高血圧学会

  198. Methodology on Study Using Administrative Data of Selective Serotonin Reuptake Inhibitors during Pregnancy and the Risk of Infants

    Aiko Shono, Taku Obara, Shinichi Kuriyama, Manabu Akazawa

    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　21　389-389　2012/08

    ISSN： 1053-8569

  199. Home blood pressure level, blood pressure variability, smoking, and stroke risk in Japanese men: The ohasama study

    Takanao Hashimoto, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

    American Journal of Hypertension　25　(8)　883-891　2012/08

    DOI： 10.1038/ajh.2012.62 　

    ISSN： 0895-7061 1941-7225

  200. Prescription of Drugs during Pregnancy in Japan Peer-reviewed

    Obara Taku, Akazawa Manabu, Ohkubo Takayoshi, Ishikuro Mami, Metoki Hirohito, Shono Aiko, Nishigori Hidekazu, Mano Nariyasu, Yaegashi Nobuo, Kuriyama Shinichi

    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　21　380　2012/08

    ISSN： 1053-8569

  201. 母親の妊娠期間中血圧値と娘の妊娠期間中血圧推移の関連 BOSHI研究

    目時 弘仁, 星川 美奈子, 大久保 孝義, 八木橋 香津代, 櫻井 香澄, 石黒 真美, 小原 拓, 菊谷 昌浩, 松原 洋一, 森 滋, 鈴木 雅洲, 佐藤 博, 栗山 進一, 八重樫 伸生, 今井 潤

    東北公衆衛生学会誌　(61)　41-41　2012/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  202. 血圧コントロール不良例の頻度とその規定因子(J-HOME研究) (特集 血圧コントロール不良への対処 : 臨床高血圧の最重要課題をどう対処しますか?) -- (血圧コントロール不良例の実際)

    小原 拓, 大久保 孝義

    治療　94　(7)　1206-1211　2012/07

    Publisher: 南山堂

    ISSN： 0022-5207

  203. Associations between day-by-day variability in blood pressure measured at home and antihypertensive drugs: The J-HOME-morning study home

    Kazuki Ishikura, Taku Obara, Tetsuo Kato, Masahiro Kikuya, Taku Shibamiya, Takahiro Shinki, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai, Makoto Yoshida, S. Aoki, H. Ido, K. Ito, K. Kikuchi, I. Maeda, T. Mito, A. Nunokawa, K. Oda, N. Suzuki, Y. Takagawa, K. Tateda, S. Tateda, M. Akimot, G. Tashima, Y. Fujii, G. Onodera, T. Onodera, N. Sugiuchi, Y. Suzuki, R. Domon, T. Hayashi, K. Ishibashi, K. Ito, S. Kataoka, S. Kyogoku, H. Mashiko, K. Matsuo, H. Metoki, Y. Otake, J. Saito, Y. Shishido, A. Takayama, Y. Tanno, S. Toyota, N. Uchida, M. Yambe, M. Fujioka, Y. Kimura, H. Matsuoka, K. Sasaki, M. Wada, H. Yamamoto, T. Goto, Y. Kamimura, H. Kitamura, Y. Matsuura, Y. Nakayama, F. Araki, Y. Miyazaki, T. Sakata, H. Sakuma, T. Sato, K. Shimizu, M. Yoshida, Y. Deguchi, T. Kano, A. Nishiyama, I. Shinotsuka, T. Kobayashi, S. Kumakura, T. Masuda, T. Watanabe, T. Honzawa, H. Kubo, H. Aoki, S. Kanozawa, H. Koide, K. Nishiyama, K. Sakamoto, J. Suda, T. Tagaya, A. Yamada, K. Yamanaka, R. Hasegawa, S. Hirai, K. Horibe, A. Jujo, M. Suzuki, N. Tamiya, T. Ueda, T. Umimura, N. Aoki, S. Arai, T. Himeno, T. Ikeda, H. Inoue, Y. Itagaki, F. Kamata, M. Kamegai, M. Kato, S. Kijima, F. Kotou, T. Kurokawa, H. Kurumatani, K. Minagawa, T. Miura, Y. Miyoshi, T. Morikawa, T. Morita, M. Nago, H. Nakada, H. Nakagawa, J. Nakamura, A. Niwa, E. Osuga, H. Ozaki, A. Sasaki, H. Sugahara, K. Suzuki, H. Tamura, H. Tomonari, M. Yamada, H. Kikuchi, T. Mikawa, K. Minamisawa, M. Miyakawa, M. Nishimura, T. Shinkai, M. Ushiyama, H. Yamamoto, S. Yokoyama, A. Horiuchi, M. Nagasaka, M. Fujita, N. Hoshiyama, M. Ikeda, A. Sakairi, T. Shinozaki, H. Takaki, K. Uchiba, H. Yanagisawa, S. Kobayashi, K. Sasaki, M. Takahashi, S. Takahashi, K. Doniwa, H. Higashi, N. Ohya, M. Yasuhara, S. Saiki, H. Ando, M. Fujii, K. Miyoshi, K. Fuchimoto, M. Kogure, K. Sugiura, T. Suzuki, N. Takahashi, Y. Takahira, N. Adachi, Y. Koyama, Y. Miyazaki, S. Nakamura, G. Narita, O. Nojiri, Y. Okamoto, K. Sakakura, M. Takasawa, T. Takenaka, H. Tatematsu, T. Uno, Y. Watanabe, N. Ishida, U. Kano, N. Morita, H. Okano, T. Takahashi, O. Yamaoka, H. Hayashi, O. Kuroda, Y. Matsushita, T. Mizuno, Y. Taniguchi, M. Yamashita, S. Arai, Y. Fujimura, S. Fujita, T. Hakuto, Y. Ikuno, H. Ishida, R. Kondo, K. Masaki, K. Nao, A. Numata, S. Saeki, H. Sakamoto, K. Suyama, K. Takada, T. Takenaka, K. Teramoto, G. Ueda, N. Wakaki, T. Yokotani, N. Handa, S. Katsuya, K. Kondo, K. Nagamatsu, K. Nakamura, T. Okano, H. Omori, N. Takahashi, Y. Tsuji, Y. Yanaka, Y. Yonezawa, Y. Matsumura, Y. Nakamura, K. Sawada, H. Shimomura, H. Suzuki, K. Furuta, N. Tamaki, Y. Wanaka, A. Inoue, M. Kamura, N. Yuhara, A. Fushimi, Y. Ido, I. Karai, K. Kurosumi, N. Maeda, T. Nishigaki, Y. Nishihara, T. Shindo, T. Yoshimoto, T. Furue, S. Ikeda, K. Kishizuchi, A. Ozawa, J. Ozawa, N. Sasaki, S. Sasaki, N. Shigeto, M. Tanabe, H. Yoshimoto, T. Hirokuni, M. Nakatsuka, T. Noda, M. Tosaka, Y. Toshima, T. Wada, M. Wakimoto, T. Yamanaka, M. Kimura, A. Ota, T. Fukui, W. Furumoto, K. Mashima, T. Nakatsu, T. Yokoi, T. Nakayama, S. Azakami, T. Eto, Y. Fujishima, Y. Fukudome, S. Goto, H. Hara, Y. Harada, T. Hoashi, K. Imoto, R. Inoue, T. Ishizaki, Y. Ito, T. Ito, T. Jinnochi, A. Kawasaki, S. Miake, J. Miyagi, K. Nagasawa, K. Okada, T. Okita, T. Otonari, Y. Tachikawa, K. Takaki, S. Tanaka, H. Urata, S. Yoshioka, H. Ikeda, R. Kaihara, T. Kuwahara, I. Matsuo, O. Nagata, H. Saito, R. Shindo, Y. Takeoka, A. Ito, S. Kusano, M. Tokunaga, S. Hamasaki, Y. Honda, K. Iwai, K. Izuno, K. Koyama, H. Maeda, A. Maki, F. Semba, S. Yi, H. K, K. Ninomiya, Y. Endo, Y. Ezaki, R. Narita, I. Hatashida, S. Komaki, R. Kuroiwa, H. Yoshii, Y. Nakamura

    Clinical and Experimental Hypertension　34　(4)　297-304　2012/07

    DOI： 10.3109/10641963.2012.681087 　

    ISSN： 1064-1963 1525-6006

  204. Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

    Michihiro Satoh, Taku Obara, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

    Clinical and Experimental Hypertension　34　(4)　284-289　2012/07

    DOI： 10.3109/10641963.2012.681085 　

    ISSN： 1064-1963 1525-6006

  205. The velocity of antihypertensive effect of losartan/hydrochlorothiazide and angiotensin II receptor blocker

    Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Ryusuke Inoue, Taku Obara, Takuo Hirose, Michihiro Sato, Takanao Hashimoto, Yutaka Imai

    Journal of Hypertension　30　(7)　1478-1486　2012/07

    DOI： 10.1097/HJH.0b013e328353f1fe 　

    ISSN： 0263-6352 1473-5598

  206. レセプトデータに基づく妊娠中の医薬品使用状況の把握に関する研究

    小原 拓, 石黒 真美, 目時 弘仁, 西郡 秀和, 大久保 孝義, 眞野 成康, 八重樫 伸生, 栗山 進一

    日本医薬品情報学会総会・学術大会講演要旨集　15回　105-105　2012/06

    Publisher: (一社)日本医薬品情報学会

  207. 妊婦コホートにおける医薬品使用状況に関する調査方法の検討

    小林 由香, 小原 拓, 目時 弘仁, 眞野 成康, 佐藤 博, 今井 潤, 八重樫 伸生, 栗山 進一

    日本医薬品情報学会総会・学術大会講演要旨集　15回　107-107　2012/06

    Publisher: (一社)日本医薬品情報学会

  208. Evaluating home blood pressure in treated hypertensives in comparison with the referential value of casual screening of blood pressure: the Ohasama study

    Daisaku Yasui, Kei Asayama, Noriko Takada, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Jan A. Staessen, Yutaka Imai

    BLOOD PRESSURE MONITORING　17　(3)　89-95　2012/06

    DOI： 10.1097/MBP.0b013e328351de34 　

    ISSN： 1359-5237

    eISSN： 1473-5725

  209. PLASMA RENIN ACTIVITY AND ALDOSTERONE-TO-RENIN RATIO ARE ASSOCIATED WITH THE DEVELOPMENT OF CHRONIC KIDNEY DISEASE: THE OHASAMA STUDY

    Michihiro Satoh, Shiho Terata, Masahiro Kikuya, Takayoshi Ohkubo, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masaaki Nakayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

    NEPHROLOGY DIALYSIS TRANSPLANTATION　27　121-121　2012/05

    ISSN： 0931-0509

  210. Blood pressure changes during pregnancy

    Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Nobuo Yaegashi, Shinichi Kuriyama, Yutaka Imai

    Hypertension Research　35　(5)　563-564　2012/05

    DOI： 10.1038/hr.2012.33 　

    ISSN： 0916-9636 1348-4214

  211. 治療中高血圧患者の高血圧管理における保険調剤薬局の関与 J-HOME-Morning研究より

    小原 拓, 小林 由香, 池田 うらら, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 大久保 孝義, 眞野 成康, 栗山 進一, 今井 潤

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　1回　101-101　2012/04

    Publisher: (NPO)日本高血圧学会

  212. 妊娠中Pulse Wave Velocity(PWV)と妊娠高血圧症候群(PIH)及び家庭血圧推移との関連 BOSHI研究

    阿久津 好美, 目時 弘仁, 大久保 孝義, 小原 拓, 石黒 真美, 山本 真実, 櫻井 香澄, 藤井 良美, 立花 郁雄, 八木橋 香津代, 菊谷 昌浩, 森 滋, 鈴木 雅洲, 佐藤 博, 松原 洋一, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　19　95-96　2012/01

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  213. 初産婦・経産婦における妊娠中の外来血圧及び家庭血圧推移 BOSHI研究

    石黒 真美, 小原 拓, 目時 弘仁, 大久保 孝義, 山本 真実, 阿久津 好美, 櫻井 香澄, 岩間 憲之, 片桐 未希子, 八木橋 香津代, 鈴木 雅洲, 八重樫 伸生, 栗山 進一, 今井 潤

    日本妊娠高血圧学会雑誌　19　99-100　2012/01

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  214. 妊娠初期の食塩摂取量と妊娠高血圧症候群発症との関連 BOSHI研究

    山本 真実, 小原 拓, 目時 弘仁, 大久保 孝義, 石黒 真美, 阿久津 好美, 櫻井 香澄, 片桐 未希子, 岩間 憲之, 八木橋 香津, 鈴木 雅洲, 栗山 進一, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　19　202-203　2012/01

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  215. PIHと脳血管障害をめぐる諸問題 24時間自由行動下血圧・家庭血圧と脳血管障害

    目時 弘仁, 大久保 孝義, 小原 拓, 阿久津 好美, 山本 真実, 石黒 真美, 櫻井 香澄, 岩間 憲之, 片桐 未希子, 菊谷 昌浩, 八木橋 香津代, 森 滋, 鈴木 雅洲, 栗山 進一, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　19　49-53　2012/01

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

    More details Close

    一般住民を対象に、24時間自由行動下血圧や家庭血圧と脳血管障害発症リスクとの関連を検討した。夜間降圧度は昼間血圧と比較して夜間血圧が0-10%低下例を夜間非降圧群、上昇例を夜間昇圧群、20%以上低下例を夜間過降圧群に分類し、脳心血管疾患による死亡リスクとの関連は24時間自由行動下血圧測定を行った1507名を対象とし、脳卒中発症リスクとの関連は脳卒中の既往のある者を除いた1430名を対象とした。また、1360名を対象にある特定の時間帯の血圧レベルと脳心血管疾患による死亡リスクを検討し、1491名を対象に家庭血圧と脳血管障害発症リスクを検討した。その結果、死亡リスクは脳梗塞では夜間昇圧群が有意に高く、脳出血では夜間過降圧群が有意に高かった。脳出血発症リスクは夜間過降圧群が有意に高く、脳梗塞発症リスクは夜間昇圧群、夜間非降圧群で通常降圧群と夜間過降圧群より有意に高かった。以上より、妊婦においても血圧変動や病型別のリスクの評価が重要であると思われた。

  216. P2-518 妊婦における葉酸サプリメント摂取の現状(妊婦・授乳婦,ポスター,一般演題,岐路に立つ医療～千年紀の目覚め～よみがえれ!ニッポン!薬の改革は我らが手で!)

    小林 由香, 小原 拓, 村井 ユリ子, 目時 弘仁, 佐藤 博, 今井 潤

    日本医療薬学会年会講演要旨集　22　(0)　464-464　2012

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.22.0_464_6 　

  217. Ambulatory Versus Home Versus Clinic Blood Pressure The Association With Subclinical Cerebrovascular Diseases: The Ohasama Study

    Azusa Hara, Kazushi Tanaka, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Hirohito Metoki, Takanao Hashimoto, Michihiro Satoh, Ryusuke Inoue, Kei Asayama, Taku Obara, Takuo Hirose, Shin-Ichi Izumi, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION　59　(1)　22-U99　2012/01

    DOI： 10.1161/HYPERTENSIONAHA.111.174938 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  218. Mother-off spring aggregation in home versus conventional blood pressure in the Tohoku Study of Child Development (TSCD)

    Kei Asayama, Jan A. Staessen, Katsuhisa Hayashi, Miki Hosaka, Nozomi Tatsuta, Naoyuki Kurokawa, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Takayoshi Ohkubo, Kunihiko Nakai, Yutaka Imai, Hiroshi Satoh

    Acta Cardiologica　67　(4)　449-456　2012

    DOI： 10.2143/AC.67.4.2170687 　

    ISSN： 0001-5385

  219. 高血圧薬物治療における家庭血圧測定と薬剤師の介入

    吉町 昌子, 小原 拓, 川端 ゆかり, 馬庭 ちはる, 河野 弘之, 眞野 成康, 大久保 孝義, 後藤 輝明

    医薬品相互作用研究　35　(2)　63-69　2011/11

    Publisher: 医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    2009年6月〜8月に11都道県の調剤薬局72店に来局した降圧薬服用患者787名を対象に、降圧治療の知識や服薬コンプライアンス、家庭血圧測定の有無などについて聞き取り調査を行った。さらに調査後、薬剤師が患者に対し、降圧治療の意義および家庭血圧測定の意義についてパンフレットを用いて説明・指導した。そして次回来局時に再度聞き取り調査を行った。初回調査の結果、「降圧治療の目的が合併症予防であることを知っている」と回答した人の割合は66.3%、「服薬を忘れることがある」と回答した人は17.9%、「家庭血圧を測定している」と回答したのは74.0%であった。次回来局時に調査を行えた386名のうち、初回調査時に家庭血圧を測定していなかったのは105名(27.2%)で、このうち薬剤師の説明・指導を受けて家庭血圧測定を開始していたのは17名(16.2%)であった。また、初回調査時に「服薬を忘れることがある」と回答していた71名のうち、薬剤師の説明・指導を受けて「服薬忘れが減った」と回答したのは40名(56.3%)であった。

  220. レセプトデータを用いた妊娠高血圧患者に対する降圧薬処方状況の把握

    小原 拓, 大久保 孝義, 目時 弘仁, 西郡 秀和, 石黒 真美, 眞野 成康, 赤沢 学, 八重樫 伸生, 栗山 進一

    日本薬剤疫学会学術総会抄録集　17回　76-77　2011/11

    Publisher: (一社)日本薬剤疫学会

  221. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 主結果報告

    大久保 孝義, 浅山 敬, 井上 隆輔, 小原 拓, 目時 弘仁, 菊谷 昌浩, 三浦 幸雄, Staessen Jan A, 今井 潤, HOMED-BP研究グループ

    日本高血圧学会総会プログラム・抄録集　34回　323-323　2011/10

    Publisher: (NPO)日本高血圧学会

  222. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 家庭血圧降圧レベルと予後との関連

    浅山 敬, 大久保 孝義, 井上 隆輔, 小原 拓, 目時 弘仁, 菊谷 昌浩, 三浦 幸雄, Staessen Jan A, 今井 潤, HOMED-BP研究グループ

    日本高血圧学会総会プログラム・抄録集　34回　327-327　2011/10

    Publisher: (NPO)日本高血圧学会

  223. 高血圧薬物治療における家庭血圧測定と薬剤師の介入

    吉町 昌子, 小原 拓, 川端 ゆかり, 馬庭 ちはる, 河野 弘之, 眞野 成康, 大久保 孝義, 後藤 輝明

    日本高血圧学会総会プログラム・抄録集　34回　621-621　2011/10

    Publisher: (NPO)日本高血圧学会

  224. 降圧治療中患者における家庭血圧日間変動の規定因子 J-HOME-Morning研究

    小原 拓, 石倉 一樹, 菊谷 昌浩, 加藤 哲夫, 芝宮 拓, 新木 貴大, 池田 うらら, 小林 由香, 目時 弘仁, 眞野 成康, 栗山 進一, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　527-527　2011/10

    Publisher: (NPO)日本高血圧学会

  225. 家庭血圧・血圧日間変動と認知機能低下との関連 大迫研究

    松本 章裕, 佐藤 倫広, 菊谷 昌浩, 大久保 孝義, 橋本 貴尚, 原 梓, 目時 弘仁, 廣瀬 卓男, 小原 拓, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 佐藤 洋, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　372-372　2011/10

    Publisher: (NPO)日本高血圧学会

  226. 血漿アルドステロン/レニン比とCKD発症に関する縦断的検討 大迫研究

    寺田 志保, 菊谷 昌浩, 佐藤 倫広, 大久保 孝義, 橋本 貴尚, 原 梓, 廣瀬 卓男, 目時 弘仁, 井上 隆輔, 小原 拓, 浅山 敬, 星 晴久, 戸恒 和人, 佐藤 洋, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　520-520　2011/10

    Publisher: (NPO)日本高血圧学会

  227. 同居家族の喫煙は家庭高血圧発症の危険因子である 大迫研究

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 関 真美, 浅山 敬, 目時 弘仁, 小原 拓, 廣瀬 卓男, 原 梓, 橋本 貴尚, 佐藤 倫広, 星 晴久, 戸恒 和人, 佐藤 洋, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　527-527　2011/10

    Publisher: (NPO)日本高血圧学会

  228. 家庭血圧によるHome Arterial Stiffness Index(HASI)と頸動脈病変との関連 大迫研究

    菊谷 昌浩, 大久保 孝義, 佐藤 倫広, 橋本 貴尚, 原 梓, 廣瀬 卓男, 目時 弘仁, 井上 隆輔, 小原 拓, 浅山 敬, 星 晴久, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　528-528　2011/10

    Publisher: (NPO)日本高血圧学会

  229. 母の家庭血圧が7歳児の家庭血圧値および家庭心拍数に与える影響について

    保坂 実樹, 浅山 敬, 龍田 希, 佐藤 倫広, 橋本 貴尚, 小原 拓, 目時 弘仁, 黒川 修行, 菊谷 昌浩, 大久保 孝義, 仲井 邦彦, Staessen Jan A, 今井 潤, 佐藤 洋

    日本高血圧学会総会プログラム・抄録集　34回　585-585　2011/10

    Publisher: (NPO)日本高血圧学会

  230. 妊娠期間中血圧推移と妊婦の母親の妊娠期間中血圧レベルとの関連 BOSHI研究

    目時 弘仁, 星川 美奈子, 大久保 孝義, 阿久津 好美, 小原 拓, 櫻井 香澄, 片桐 未希子, 岩間 憲之, 八木橋 香津代, 森 滋, 鈴木 雅洲, 栗山 進一, 松原 洋一, 八重樫 伸生, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　437-437　2011/10

    Publisher: (NPO)日本高血圧学会

  231. 正常妊娠における妊娠初期ヘマトクリット(Ht)と家庭血圧推移との関連 BOSHI研究

    阿久津 好美, 佐々木 彩乃, 目時 弘仁, 大久保 孝義, 小原 拓, 櫻井 香澄, 八木橋 香津代, 菊谷 昌浩, 森 滋, 鈴木 雅洲, 佐藤 博, 栗山 進一, 松原 洋一, 八重樫 伸生, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　585-585　2011/10

    Publisher: (NPO)日本高血圧学会

  232. 降圧治療中患者における減塩の医療経済効果

    佐藤 慶子, 大久保 孝義, 小林 慎, 菊谷 昌浩, 小原 拓, 目時 弘仁, 浅山 敬, 鈴木 一夫, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　520-520　2011/10

    Publisher: (NPO)日本高血圧学会

  233. 家庭血圧測定に基づくβ遮断薬ビソプロロールの脈拍減少、降圧および降圧速度の評価

    佐藤 倫広, 小原 拓, 池田 うらら, 小林 由香, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　583-583　2011/10

    Publisher: (NPO)日本高血圧学会

  234. 一般住民における血漿アルドステロン/血漿レニン活性比(ARR)とnon-dippingおよびNa排泄量との関連 大迫研究

    佐藤 倫広, 菊谷 昌浩, 大久保 孝義, 森 建文, 橋本 貴尚, 目時 弘仁, 原 梓, 坪田 恵, 廣瀬 卓男, 小原 拓, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　518-518　2011/10

    Publisher: (NPO)日本高血圧学会

  235. 喫煙習慣は男性における家庭血圧値・血圧日間変動の脳卒中発症リスクを上昇させるか? 大迫研究

    橋本 貴尚, 菊谷 昌浩, 大久保 孝義, 佐藤 倫広, 目時 弘仁, 井上 隆輔, 浅山 敬, 菅野 厚博, 小原 拓, 廣瀬 卓男, 星 晴久, 戸恒 和人, 佐藤 洋, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　477-477　2011/10

    Publisher: (NPO)日本高血圧学会

  236. 降圧治療中患者における早朝家庭血圧管理と脳心血管疾患発症との関連 J-HOME-Morning研究

    池田 うらら, 小原 拓, 大久保 孝義, 菊谷 昌浩, 小林 由香, 石倉 一樹, 目時 弘仁, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　528-528　2011/10

    Publisher: (NPO)日本高血圧学会

  237. P-0943 うつ症状と労働状況、および睡眠薬服用状況に関する実態調査 : 社団法人仙台市薬剤師会(一般演題 ポスター発表,精神科領域,Enjoy Pharmacists' Lifestyles)

    佐藤 倫広, 小原 拓, 高橋 將喜, 早坂 正孝, 鎌田 裕, 北村 哲治

    日本医療薬学会年会講演要旨集　21　339-339　2011/09/09

    Publisher: 日本医療薬学会

  238. スズキ記念病院(産科系病院)におけるお薬相談の実績と展望

    岩崎 雅弘, 小原 拓, 西村 美里, 目時 弘仁, 鈴木 瑛美, 吉田 美希, 館 圭, 松田 祐子, 蛯子 学, 佐藤 友理恵, 渡邉 悠美子, 八木橋 香津代, 大久保 孝義, 今井 潤, 鈴木 雅州

    医薬品相互作用研究　34　(3)　145-149　2011/04

    Publisher: 医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    「お薬相談窓口」のこれまでの実績を集計・評価し、相談窓口に寄せられた相談内容の把握と今後の対応の体制について検討した。2001年から2006年の相談内容を対象とした。相談者1013例中、98.0%が女性であった。全相談件数は1013件、平均相談件数は169件であった。相談の対象となった薬剤は医療用医薬品が最も多く89.3%、続いて一般用医薬品16.0%、サプリメント・健康食品3.1%の順であった。当院から処方された薬に関する相談は56.4%、他院から処方された薬に関する相談は23.8%であった。最も多く寄せられた相談内容は薬剤使用の可否に関する相談で(25.8%)、続いて使用・服用方法に関する相談20.3%、副作用に関する相談16.7%、相互作用に関する相談16.0%であった。ホルモン剤に関する相談が最も多く39.0%、続いて抗生物質15.8%、消炎・鎮痛・酵素薬14.1%であった。

  239. スズキ記念病院における妊婦への処方状況 BOSHI研究

    佐々木 彩乃, 目時 弘仁, 佐藤 友里恵, 星川 美奈子, 阿久津 好美, 小原 拓, 大久保 孝義, 岩崎 雅弘, 今井 潤, 鈴木 雅州

    日本薬学会年会要旨集　131年会　(4)　181-181　2011/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  240. 家庭血圧測定に基づくCa拮抗薬エホニジピン塩酸塩の臨床評価

    小林 由香, 石倉 一樹, 小原 拓, 吉田 愛琴, 池田 うらら, 廣瀬 卓男, 大久保 孝義, 佐藤 博, 今井 潤

    Therapeutic Research　32　(3)　349-355　2011/03

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

    More details Close

    早朝血圧の降圧が不十分であった本態性高血圧患者25例(男9例・女16例・平均69.8歳)に対してエホニジピン塩酸塩40mg/日を追加投与し、家庭血圧測定によりその効果を検討した。早朝家庭血圧は、追加開始4週後、8週後に収縮期血圧、拡張期血圧とも有意な低下を認め、心拍数は変化がなかった。就寝前家庭血圧は、収縮期血圧、拡張期血圧とも有意な低下は認めず、心拍数は有意に低下した。就寝前家庭血圧降圧度/早朝家庭血圧降圧度(E/M比)は、一定以上の降圧を認めた対象者のindividual E/M比、全対象者のoverall E/M比が4週後、8週後とも0.5未満であった。就寝前家庭収縮期血圧135mmHg未満の管理良好群は21例、135mmHg以上の管理不良群は4例で、就寝前家庭収縮期血圧の降圧度に有意な差はなかったが、管理不良群の方が大きかった。また管理不良群のoverall E/M比は、管理良好群に比べて大きい傾向を示した。以上よりエホニジピンの就寝前服用は早朝血圧降圧不十分な患者に対して有効である可能性があると考えられた。

  241. 家庭血圧測定を用いた低用量エプレレノン(25mg/日)の有用性に関する検討

    石倉 一樹, 小原 拓, 吉田 愛琴, 池田 うらら, 佐々木 彩乃, 廣瀬 卓男, 大久保 孝義, 今井 潤

    Therapeutic Research　32　(3)　357-364　2011/03

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

    More details Close

    早朝血圧の降圧が不十分であった本態性高血圧患者24例(男15例・女9例・平均63.8歳)に対してエプレレノン25mg/日を追加投与し、4週後、8週後の効果を家庭血圧測定により検討した。早朝収縮期血圧(SBP)および拡張期血圧(DBP)、外来SBPは有意な低下を認め、就寝前SBP、就寝前・外来DBP、各種心拍数は変化がなかった。エプレレノンを朝食後服用した10例では早朝・就寝前・外来SBPに有意な低下を認めたが、DBP、心拍数は変化がなかった。就寝前服用11例では早朝SBP・DBP・心拍数に有意な低下を認め、就寝前血圧・心拍数、外来血圧・心拍数は変化がなかった。4週後と8週後の早朝DBPの降圧率は朝食後服用群に比べ、就寝前服用群で有意に大きく、早朝SBP、DBPの降圧率は大きい傾向を示した。朝食後服用群の就寝前血圧降圧度/早朝血圧降圧度は、8週後のDBPを除いて0.5を超えていたが、就寝前服用群は0.5未満であった。以上より、エプレレノン25mg/日追加服用は早朝SBPを有意に低下させた。また、就寝前服用の方が早朝血圧の降圧効果が大きいと考えられた。

  242. 高血圧専門外来に通院中の高血圧患者における家庭血圧測定

    吉田 愛琴, 小原 拓, 石倉 一樹, 池田 うらら, 眞野 成康, 大久保 孝義, 今井 潤

    血圧　18　(3)　279-285　2011/03

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    高血圧専門外来に通院中の高血圧患者における家庭血圧測定の実態調査を行った。通院中の高血圧患者450例を対象に、家庭血圧測定および記録値に関する自記式アンケート調査を実施した。回答が得られた394例のデータを解析した。医師が厳密な家庭血圧測定の指導をおこなっている対象者においては、ガイドラインの推奨通りに家庭血圧を測定している割合が高かった。ガイドラインで推奨されている測定条件のうち「1〜2分の安静後」を順守する割合が他の条件と比較し低かった。また、朝の測定条件において、ガイドラインで推奨されているすべての条件を順守している割合は約40%であった。医師による厳密な家庭血圧測定の指導が患者の家庭血圧測定の質を高めることが示唆された。1機会に「1回のみ」測定すると回答した対象者の測定値を記録する割合は朝・晩の測定ともに9割以上で、1回測定のほとんどの患者がその値を記録していた。

  243. ロスバスタチン2.5mg隔日服用における脂質改善効果および降圧効果の評価

    佐々木 彩乃, 小原 拓, 石倉 一樹, 吉田 愛琴, 池田 うらら, 目時 弘仁, 大久保 孝義, 佐藤 博, 今井 潤

    Therapeutic Research　32　(2)　223-230　2011/02

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

    More details Close

    脂質異常症合併高血圧症例で、ロバスタチン2.5mgを隔日で服用を開始した54例(平均年齢61.5歳、女25名)を対象に脂質改善効果を検討した。服用後8週間後の中性脂肪、総コレステロール、LDL-コレステロール/HDL-コレステロール(HDL-C)比は有意に低下した。HDL-Cの有意な上昇も認めた。これまで連日服用で明らかになっていたロスバスタチンの改善効果が、低用量隔日服用でも認めた。肝機能、腎機能の指標に有意な変化は認めなかったが、クレアチニンホスホキナーゼに上昇傾向を認めた。家庭血圧、心拍に有意な変化は見られなかったが、家庭血圧管理不良群に、早朝の収縮期血圧に低下傾向を認め、服用前の収縮期血圧レベルと降圧度の大きさに有意な相関を認めた。処方前後の服薬アドヒアランスの比較では、有意な変化は認めなかった。

  244. Role of Pharmacists in the Management of Hypertensive Patients

    Taku Obara, Sentaro Oide, Takayoshi Ohkubo, Nariyasu Mano, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　24　(1)　2-3　2011/01

    DOI： 10.1038/ajh.2010.208 　

    ISSN： 0895-7061

  245. 家庭血圧測定にもとづく選択的アルドステロン受容体拮抗薬エプレレノン25mg/日の臨床評価 スピロノラクトン12.5mg/日からの切り替え

    石倉 一樹, 小原 拓, 吉田 愛琴, 池田 うらら, 佐々木 彩乃, 廣瀬 卓男, 大久保 孝義, 今井 潤

    血圧　17　(12)　1058-1062　2010/12

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    通院中の本態性高血圧患者37例(男18例・女19例・平均66.9歳)に対し、スピロノラクトン12.5mg/日からエプレレノン25mg/日への切り替えを行い、家庭血圧測定値により有効性を検討した。切り替え8週後において、就寝前の収縮期血圧は平均126.2mmHgから121.2mmHgに、拡張期血圧は71.8mmHgから68.0mmHgに有意に低下した。早朝収縮期・拡張期血圧、家庭心拍数、外来での血圧値・心拍数に有意な変化はなかった。用法別にみると、スピロノラクトン朝食後服用からエプレレノン朝食後服用に切り替えた12例ではいずれの測定値も有意な変化はなく、エプレレノン就寝前服用に切り替えた18例では就寝前拡張期血圧が有意に低下した。生化学検査値をみると、血清Na値、Cl値の平均値が切り替え後有意に低下した。早朝血圧管理においては、スピロノラクトン12.5mg/日とエプレレノン25mg/日の有効性に差がない可能性が示唆された。

  246. 母親の妊娠期間中血圧値と娘の妊娠期間中血圧推移の関連 BOSHI研究

    星川 美奈子, 目時 弘仁, 大久保 考義, 佐藤 友里恵, 佐々木 彩乃, 阿久津 好美, 白石 彩, 八木橋 香津代, 櫻井 香澄, 小原 拓, 菊谷 昌浩, 松原 洋一, 森 滋, 鈴木 雅洲, 佐藤 博, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　18　180-181　2010/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  247. 正常妊娠における妊娠初期ヘマトクリット(Ht)と家庭血圧推移との関連 BOSHI研究

    佐々木 彩乃, 目時 弘仁, 大久保 孝義, 佐藤 友里恵, 星川 美奈子, 阿久津 好美, 白石 彩, 八木橋 香津代, 櫻井 香澄, 小原 拓, 菊谷 昌浩, 松原 洋一, 森 滋, 鈴木 雅洲, 佐藤 博, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　18　142-143　2010/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  248. 妊婦の出生体重及び妊娠前肥満度と妊娠中の家庭血圧推移 BOSHI研究

    佐藤 友里恵, 目時 弘仁, 大久保 孝義, 佐々木 彩乃, 星川 美奈子, 阿久津 好美, 白石 彩, 八木橋 香津代, 櫻井 香澄, 小原 拓, 菊谷 昌浩, 松原 洋一, 森 滋, 鈴木 雅洲, 佐藤 博, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　18　146-147　2010/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  249. 妊娠期間中の血圧推移 BOSHI研究

    目時 弘仁, 大久保 孝義, 佐藤 友里恵, 佐々木 彩乃, 星川 美奈子, 阿久津 好美, 白石 彩, 八木橋 香津代, 櫻井 香澄, 小原 拓, 菊谷 昌浩, 伊藤 潔, 松原 洋一, 森 滋, 鈴木 雅洲, 佐藤 博, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　18　193-194　2010/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  250. P2-503 家庭血圧測定に基づく低用量エプレレノン(25mg/日)の臨床評価(一般演題 ポスター発表,薬物療法(その他),臨床から学び臨床へと還元する医療薬学)

    石倉 一樹, 小原 拓, 吉田 愛琴, 池田 うらら, 佐々木 彩乃, 廣瀬 卓男, 大久保 孝義, 今井 潤

    日本医療薬学会年会講演要旨集　20　473-473　2010/10/25

    Publisher: 日本医療薬学会

  251. P2-502 家庭血圧測定に基づくアンジオテンシンII受容体拮抗薬イルベサルタンの降圧効果および薬効持続に関する検討(一般演題 ポスター発表,薬物療法(その他),臨床から学び臨床へと還元する医療薬学)

    吉田 愛琴, 小原 拓, 石倉 一樹, 小林 由香, 廣瀬 卓男, 大久保 孝義, 眞野 成康, 今井 潤

    日本医療薬学会年会講演要旨集　20　473-473　2010/10/25

    Publisher: 日本医療薬学会

  252. P1-125 日本の高血圧診療における利尿薬使用の現状 : J-HOME Morning研究(一般演題 ポスター発表,使用状况調査・意識調査,臨床から学び臨床へと還元する医療薬学)

    池田 うらら, 小原 拓, 石倉 一樹, 吉田 愛琴, 小林 由香, 大久保 孝義, 佐藤 博, 今井 潤

    日本医療薬学会年会講演要旨集　20　307-307　2010/10/25

    Publisher: 日本医療薬学会

  253. P2-138 ロサルタン/ヒドロクロロチアジド合剤の医療経済学的評価 : 家庭血圧を用いた検討(一般演題 ポスター発表,薬剤疫学・医療経済,臨床から学び臨床へと還元する医療薬学)

    佐藤 慶子, 大久保 孝義, 小林 慎, 目時 弘仁, 小原 拓, 浅山 敬, 井上 隆輔, 佐藤 博, 今井 潤

    日本医療薬学会年会講演要旨集　20　413-413　2010/10/25

    Publisher: 日本医療薬学会

  254. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 対象者のベースライン特性 HOMED-BP研究グループを代表して

    大久保 孝義, 浅山 敬, 高橋 ちひろ, 井上 隆輔, 目時 弘仁, 小原 拓, 三浦 幸雄, 今井 潤

    日本高血圧学会総会プログラム・抄録集　33回　273-273　2010/10

    Publisher: (NPO)日本高血圧学会

  255. 降圧治療中患者における家庭血圧管理と腎機能低下に関する縦断的検討 J-HOME-Morning研究

    石倉 一樹, 小原 拓, 吉田 愛琴, 池田 うらら, 目時 弘仁, 井上 隆輔, 浅山 敬, 中山 昌明, 菊谷 昌浩, 大久保 孝義, 今井 潤, J-HOME-Mornig研究グループ

    日本高血圧学会総会プログラム・抄録集　33回　277-277　2010/10

    Publisher: (NPO)日本高血圧学会

  256. カルシウム拮抗薬・アンジオテンシン変換酵素阻害薬・アンジオテンシンII受容体拮抗薬の単剤服用者への、利尿薬併用効果に関する利尿薬種別・用量別検討 HOMED-BP研究サブ分析

    高橋 ちひろ, 浅山 敬, 井上 隆輔, 大久保 孝義, 目時 弘仁, 小原 拓, 三浦 幸雄, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集　33回　378-378　2010/10

    Publisher: (NPO)日本高血圧学会

  257. 家庭血圧測定に基づくカルシウム拮抗薬シルニジピンの降圧効果および薬効持続の検討

    吉田 愛琴, 小原 拓, 石倉 一樹, 佐々木 彩乃, 池田 うらら, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 眞野 成康, 今井 潤

    日本高血圧学会総会プログラム・抄録集　33回　372-372　2010/10

    Publisher: (NPO)日本高血圧学会

  258. アドレノメデュリン2/インターメジン遺伝子多型と血圧、腎機能、無症候性脳血管障害との関連の検討 大迫研究

    廣瀬 卓男, 戸恒 和人, 目時 弘仁, 原 梓, 佐藤 倫広, 小原 拓, 浅山 敬, 菊谷 昌浩, 近藤 健男, 大久保 孝義, 出江 紳一, 高橋 和広, 今井 潤

    日本高血圧学会総会プログラム・抄録集　33回　379-379　2010/10

    Publisher: (NPO)日本高血圧学会

  259. 家庭血圧を指標とする降圧薬反応性のゲノムワイド解析 HOMED-BP-GENE研究

    勝谷 友宏, 浅山 敬, 大久保 孝義, 杉本 研, 神出 計, 井上 隆輔, 目時 弘仁, 小原 拓, 大石 充, 森下 竜一, 荻原 俊男, 今井 潤, 楽木 宏実

    日本高血圧学会総会プログラム・抄録集　33回　333-333　2010/10

    Publisher: (NPO)日本高血圧学会

  260. 一般住民における血清アルドステロン/血漿レニン活性比(ARR)と脳卒中発症およびNa摂取量との関連 大迫研究

    佐藤 倫広, 菊谷 昌浩, 原 梓, 大久保 孝義, 森 建文, 目時 弘仁, 宇津木 恵, 廣瀬 卓男, 小原 拓, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　33回　236-236　2010/10

    Publisher: (NPO)日本高血圧学会

  261. 受動喫煙の家庭血圧に対する影響 大迫研究

    関 真美, 井上 隆輔, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 浅山 敬, 原 梓, 廣瀬 卓男, 菅野 厚博, 小原 拓, 橋本 貴尚, 星 晴久, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　33回　281-281　2010/10

    Publisher: (NPO)日本高血圧学会

  262. Association of environmental tobacco smoke exposure with elevated home blood pressure in Japanese women: The Ohasama study

    Mami Seki, Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Hirohito Metoki, Takuo Hirose, Megumi Tsubota-Utsugi, Kei Asayama, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    Journal of Hypertension　28　(9)　1814-1820　2010/09

    DOI： 10.1097/HJH.0b013e32833a3911 　

    ISSN： 0263-6352

  263. DECREASED MID PREGNANCY FALL IN HOME BLOOD PRESSURE IN RELATION TO INSULIN RESISTANCE: THE BOSHI STUDY

    M. Kawaguchi, H. Metoki, T. Ohkubo, Y. Sato, A. Sasaki, M. Hoshikawa, K. Akutsu, K. Yagihashi, T. Hashimoto, A. Hara, T. Obara, M. Kikuya, N. Yaegashi, K. Okamura, Y. Matsubara, S. Mori, M. Suzuki, Y. Imai

    JOURNAL OF HYPERTENSION　28　E13-E13　2010/06

    ISSN： 0263-6352

  264. Cost-effectiveness of hypertension treatment based on the measurement of ambulatory blood pressure

    Yuichiro Tamaki, Takayoshi Ohkubo, Makoto Kobayashi, Keiko Sato, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Kei Asayama, Takuo Hirose, Kazuhito Totsune, Kazuo Suzuki, Yutaka Imai

    Yakugaku Zasshi　130　(6)　805-820　2010/06

    Publisher: The Pharmaceutical Society of Japan

    DOI： 10.1248/yakushi.130.805 　

    ISSN： 0031-6903 1347-5231

  265. アンジオテンシンII受容体拮抗薬テルミサルタンの家庭血圧測定にもとづく降圧速度に関する検討

    安 真美子, 小原 拓, 花澤 智大, 小笠原 慧, 堅田 早紀子, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 今井 潤

    血圧　17　(5)　445-449　2010/05

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    早朝平均収縮期血圧135mmHg以上/平均拡張期血圧85mmHg以上の未治療本態性高血圧患者20名(男9名、女11名、年齢60.1±7.4歳)を対象にテルミサルタン40mg 1日1回朝食後服用後の家庭血圧の推移を単純指数関数にフィッティングさせ、降圧効果安定化までの時間(stabilizing time)を求めた。早朝および就寝前心拍に有意な変化は認めなかったが、早朝および就寝前の血圧を有意に低下させ、最大降圧度は早朝収縮期血圧13.7mmHgでstabilizing timeは8.9日、早朝拡張期血圧6.8mmHgでstabilizing timeは9.6日であり、就寝前収縮期血圧は15.2mmHgでstabilizing time 8.6日、就寝前拡張期血圧7.8mmHgでstabilizing time 7.7日であった。また、家庭低血圧推移は降圧レベルによらず指数関数に有意にフィッティングし、フィッティング度合を表す回帰係数Rは0.72〜0.80でstabilizing timeは8.3〜12.6日であった。

  266. アンジオテンシンII受容体拮抗薬オルメサルタンの家庭血圧測定に基づく降圧速度に関する検討

    小原 拓, 安 真美子, 花澤 智大, 小笠原 慧, 堅田 早紀子, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 眞野 成康, 今井 潤

    Therapeutic Research　31　(4)　569-575　2010/04

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

    More details Close

    未治療の本態性高血圧患者26例を対象にオルメサルタン20mgを4週間投与し、その効果を家庭用血圧測定に基づく降圧度と降圧速度より検討した。その結果、早朝家庭血圧において治療4週後の降圧度は16.4/9.3 mmHgであり、降圧効果安定化までの時間は約9日であることが示唆された。

  267. 母親の妊娠期間中血圧レベルと娘の妊娠期間中血圧推移の関連 BOSHI研究

    星川 美奈子, 目時 弘仁, 大久保 孝義, 川口 麻衣子, 佐藤 友里恵, 佐々木 綾乃, 阿久津 好美, 八木橋 香津代, 橋本 貴尚, 原 梓, 小原 拓, 八重樫 伸生, 松原 洋一, 鈴木 雅洲, 今井 潤

    日本衛生学雑誌　65　(2)　282-282　2010/04

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

  268. アンジオテンシンII受容体拮抗薬ロサルタンの家庭血圧測定にもとづく降圧速度に関する検討

    安 真美子, 小原 拓, 花澤 智大, 小笠原 慧, 堅田 早紀子, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 今井 潤

    血圧　17　(2)　145-150　2010/02

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    未治療本態性高血圧患者23例(男12例・女11例・平均64.1歳)にロサルタン50mg/日を1日1回4週間投与し、家庭血圧測定によりその効果を検討した。早朝収縮期/拡張期血圧は治療開始前平均152.1/90.4mmHgで、降圧度は治療2週目で8.9/4.9mmHg、4週目で12.5/7.5mmHgと有意な変化を認めた。就寝前血圧は平均142.4/83.1mmHgで、降圧度は2週目13.5/7.7mmHg、4週目11.6/7.7mmHgであった。降圧速度に関してMashimaらの研究に基づくフィッティング解析を行ったところ、収縮期/拡張期血圧の推移は指数関数に有意にフィッティングした。早朝収縮期血圧の最大降圧度は11.9mmHg、stabilizing timeは22.8日、拡張期血圧はそれぞれ7.3mmHg、24.1日であった。同様に、就寝前血圧も指数関数に有意にフィッテイングし、就寝前収縮期血圧の最大降圧度は11.4mmHg、stabilizing timeは20.9日、拡張期血圧はそれぞれ6.7mmHg、21.7日であった。降圧レベル別に解析した結果も同様であった。

  269. White-coat hypertension, masked hypertension, and morning hypertension based on home blood pressure measurement

    59　(1)　18-23　2010/01

    Publisher: 永井書店

    ISSN： 0371-1900

  270. Home and office blood pressure control among treated hypertensive patients in Japan: Findings from the Japan home versus office blood pressure measurement evaluation (J-HOME) study

    Taku Obara, Takayoshi Ohkubo, Michihiro Satoh, Nariyasu Mano, Yutaka Imai

    Pharmaceuticals　3　(2)　419-432　2010

    DOI： 10.3390/ph3020419 　

    ISSN： 1424-8247

  271. 妊娠高血圧症候群の診断をめぐるピットフォール 高血圧診断の問題点

    目時 弘仁, 大久保 孝義, 佐藤 友里恵, 佐々木 彩乃, 星川 美奈子, 川口 麻衣子, 阿久津 好美, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 八木橋 香津代, 八重樫 伸生, 岡村 州博, 松原 洋一, 森 滋, 鈴木 雅洲, 今井 潤

    日本妊娠高血圧学会雑誌　17　29-32　2009/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

    More details Close

    前向きコホート研究で妊娠が判明した妊婦278人(17〜41歳・平均31歳)に対し書面による説明・同意の上、妊娠期間中の血圧推移について家庭血圧を中心に検討した。研究では主に妊娠期間中の血圧変動に関わる因子を検討した。妊娠高血圧腎症発症には季節変動があり、冬期に増加することが知られているが冬期に出産予定の妊婦は他の時期出産予定の妊婦に比べ妊娠中期の血圧が低かった。妊娠期間中の家庭血圧レベルはたとえ正常血圧レベルであっても妊娠週数ばかりでなく、季節要因やその他の交絡要因により影響を受けていた。また、外来・家庭血圧の相関は妊娠週数により異なり、妊娠初期において白衣効果が大きく、妊娠経過につれ、集団における白衣効果は減少した。妊娠期間中の高血圧の診断や予測に関してはこれらの要因を考慮した上で判断する必要があると思われた。

  272. 正常血圧妊婦のインスリン抵抗性と妊娠中期の血圧低下との関連 BOSHI研究

    川口 麻衣子, 目時 弘仁, 大久保 孝義, 佐々木 彩乃, 星川 美奈子, 阿久津 好美, 八木橋 香津代, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 松原 洋一, 八重樫 伸生, 岡村 州博, 森 滋, 鈴木 雅洲, 今井 潤

    日本妊娠高血圧学会雑誌　17　186-187　2009/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  273. 妊娠前BMIと妊娠中の家庭血圧推移 BOSHI研究

    佐藤 友里恵, 目時 弘仁, 大久保 孝義, 川口 麻衣子, 阿久津 好美, 佐々木 彩乃, 星川 美奈子, 八木橋 香津代, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 松原 洋一, 八重樫 伸生, 岡村 州博, 森 滋, 鈴木 雅洲, 今井 潤

    日本妊娠高血圧学会雑誌　17　192-193　2009/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  274. Evaluation of blood pressure

    Japanese journal of clinical medicine　67　51-56　2009/11

    Publisher: 日本臨床社

    ISSN： 0047-1852

  275. Long-Term Risk in Subjects With White-Coat Hypertension

    Taku Obara, Takayoshi Ohkubo, Yutaka Imai

    HYPERTENSION　54　(5)　E133-E133　2009/11

    DOI： 10.1161/HYPERTENSIONAHA.109.140111 　

    ISSN： 0194-911X

  276. Influence of Alcohol Intake on Circadian Blood Pressure Variation in Japanese Men: The Ohasama Study

    Manami Nakashita, Takayoshi Ohkubo, Azusa Hara, Hirohito Metoki, Masahiro Kikuya, Takuo Hirose, Megumi Tsubota-Utsugi, Kei Asayama, Ryusuke Inoue, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　22　(11)　1171-1176　2009/11

    DOI： 10.1038/ajh.2009.160 　

    ISSN： 0895-7061

  277. 家庭血圧・自由行動下血圧に基づく循環器病の予防戦略-大迫研究

    今井 潤, 浅山 敬, 井上 隆輔, 小原 拓, 菊谷 昌浩, 大久保 孝義

    日本循環器病予防学会誌 = Japanese journal of cardiovascular disease prevention　44　(3)　200-212　2009/10/30

    ISSN： 1346-6267

  278. 家庭血圧測定の現状に関する調査 保健師の実践と意識

    渡邊 生恵, 小原 拓, 大久保 孝義, 丸山 良子, 今井 潤

    日本公衆衛生学会総会抄録集　68回　588-588　2009/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  279. 降圧治療中患者における家庭血圧管理と心電図上左室肥大改善に関する縦断的検討 J-HOME-Morning研究

    芝宮 拓, 小原 拓, 新木 貴大, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 今井 潤, J-HOME-Morning研究グループ

    日本高血圧学会総会プログラム・抄録集　32回　191-191　2009/10

    Publisher: (NPO)日本高血圧学会

  280. 高血圧患者におけるβ遮断薬投与の家庭心拍減少および降圧効果検証のための介入研究 J-HOME-HR研究

    新木 貴大, 小原 拓, 大久保 孝義, 後ノ上 健太, 芝宮 拓, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 今井 潤, J-HOME-HR研究グループ

    日本高血圧学会総会プログラム・抄録集　32回　205-205　2009/10

    Publisher: (NPO)日本高血圧学会

  281. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 終了予定変更とその根拠

    大久保 孝義, 浅山 敬, 井上 隆輔, 目時 弘仁, 小原 拓, 三浦 幸雄, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　206-206　2009/10

    Publisher: (NPO)日本高血圧学会

  282. 本態性高血圧患者に対する低用量(12.5-25mg/日)スピロノラクトン追加投与の有用性

    花澤 智大, 小笠原 慧, 小原 拓, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　297-297　2009/10

    Publisher: (NPO)日本高血圧学会

  283. Serum magnesium, ambulatory blood pressure, and the prevalence of carotid artery alteration: The Ohasama study

    T. Hashimoto, A. Hara, T. Ohkubo, M. Kikuya, Y. Shintani, H. Metoki, R. Inoue, K. Asayama, A. Kanno, M. Nakashita, T. Obara, K. Totsune, H. Hoshi, H. Sato, Y. Imai

    INTERNATIONAL JOURNAL OF CARDIOLOGY　137　S145-S145　2009/10

    DOI： 10.1016/j.ijcard.2009.09.499 　

    ISSN： 0167-5273

  284. 白衣効果と脳卒中発症 大迫研究

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 浅山 敬, 原 梓, 廣瀬 卓男, 菅野 厚博, 小原 拓, 星 晴久, 戸恒 和人, 佐藤 洋, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　159-159　2009/10

    Publisher: (NPO)日本高血圧学会

  285. 飲酒習慣が血圧日内変動に及ぼす影響 大迫研究

    中下 愛実, 大久保 孝義, 原 梓, 菊谷 昌浩, 目時 弘仁, 宇津木 恵, 浅山 敬, 井上 隆輔, 菅野 厚博, 橋本 貴尚, 小原 拓, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　239-239　2009/10

    Publisher: (NPO)日本高血圧学会

  286. 治療中高血圧患者における家庭血圧コントロール改善・悪化の要因に関する検討 J-HOME-Morning研究

    小原 拓, 小林 満, 芝宮 拓, 新木 貴大, 原 梓, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 眞野 成康, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　263-263　2009/10

    Publisher: (NPO)日本高血圧学会

  287. 血漿アルドステロン/レニン活性比と高血圧有病およびNa摂取量との関連 家庭血圧を用いた検討(大迫研究)

    佐藤 倫広, 菊谷 昌浩, 原 梓, 大久保 孝義, 森 建文, 目時 弘仁, 宇津木 恵, 井上 隆輔, 浅山 敬, 小原 拓, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　318-318　2009/10

    Publisher: (NPO)日本高血圧学会

  288. (プロ)レニン受容体の遺伝子・タンパク質発現 心不全モデルでの検討

    川村 卓也, 戸恒 和人, 廣瀬 卓男, 森 信芳, 原 梓, 小原 拓, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 上月 正博, 高橋 和広, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　237-237　2009/10

    Publisher: (NPO)日本高血圧学会

  289. アドレノメデュリン2/インターメジン遺伝子多型と無症候性脳血管障害との関連の検討 大迫研究

    廣瀬 卓男, 戸恒 和人, 川村 卓也, 目時 弘仁, 星川 美奈子, 原 梓, 小原 拓, 浅山 敬, 菊谷 昌浩, 近藤 健男, 大久保 孝義, 出江 紳一, 高橋 和広, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　267-267　2009/10

    Publisher: (NPO)日本高血圧学会

  290. 妊娠期間中の家庭血圧測定から得られる血行動態データと季節要因の検討 BOSHI研究

    目時 弘仁, 大久保 孝義, 川口 麻衣子, 佐藤 友里恵, 阿久津 好美, 八木橋 香津代, 原 梓, 小原 拓, 菊谷 昌浩, 八重樫 伸生, 岡村 州博, 松原 洋一, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　305-305　2009/10

    Publisher: (NPO)日本高血圧学会

  291. 正常妊婦における妊娠前肥満度と妊娠中の家庭血圧推移 BOSHI研究

    佐藤 友里恵, 目時 弘仁, 大久保 孝義, 川口 麻衣子, 阿久津 好美, 星川 美奈子, 八木橋 香津代, 廣瀬 卓男, 小原 拓, 松原 洋一, 八重樫 伸生, 岡村 州博, 森 茂, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　305-305　2009/10

    Publisher: (NPO)日本高血圧学会

  292. 高齢者高血圧患者における早朝家庭血圧管理と降圧治療 J-HOME-Elderly研究

    小原 拓, 芝宮 拓, 新木 貴大, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 眞野 成康, 今井 潤

    日本高血圧学会総会プログラム・抄録集　32回　214-214　2009/10

    Publisher: (NPO)日本高血圧学会

  293. サプリメント摂取者の人口学的特性及び生活習慣に関する研究 大迫研究

    原 梓, 大久保 孝義, 小原 拓, 坪田 恵, 宇津木, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 細川 徹, 佐藤 洋, 今井 潤

    医薬品相互作用研究　33　(1)　7-13　2009/09

    Publisher: 医薬品相互作用研究会

    ISSN： 0385-5015

    More details Close

    一般地域住民におけるサプリメント摂取者の特性及び生活習慣について検討した。岩手県花巻市大迫町における高血圧・循環器疾患に関する長期コホート研究の一環である。「生活習慣と健康に関するアンケート調査」に回答した、35歳以上の岩手県花巻市大迫町の地域住民4227例を対象とした。単変量解析でサプリメント摂取と関連が認められた因子と年齢を補正項目とし、サプリメント摂取に対するオッズ比をロジスティック回帰分析で解析した。女性において、サプリメントの摂取は、高齢、飲酒歴あり、体力不足、主観的健康度不良、学歴高校卒業以上、週1回以上の外食習慣と有意に関連した。男性において、サプリメントの摂取は、疾病既往あり、朝食の毎日摂取と有意に関連した。女性において、外向性傾向および神経症傾向がサプリメント摂取と有意に関連していた。男性において、神経症傾向とサプリメント摂取との間に有意な関連を認めた。

  294. Stroke Risk of Blood Pressure Indices Determined by Home Blood Pressure Measurement The Ohasama Study

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    STROKE　40　(8)　2859-2861　2009/08

    DOI： 10.1161/STROKEAHA.108.546499 　

    ISSN： 0039-2499

  295. 家庭血圧測定に基づくアムロジピンベシル酸塩の後発医薬品の臨床評価

    小原 拓, 池田 うらら, 新木 貴大, 芝宮 拓, 大久保 孝義, 眞野 成康, 今井 潤

    ジェネリック研究　3　(増刊号)　93-93　2009/06

    Publisher: 日本ジェネリック医薬品・バイオシミラー学会

    ISSN： 1881-9117

  296. 薬剤師における後発医薬品導入における認識

    小原 拓, 高橋 將喜, 高橋 則男, 北村 哲治, 大久保 孝義, 眞野 成康, 今井 潤

    ジェネリック研究　3　(増刊号)　110-110　2009/06

    Publisher: 日本ジェネリック医薬品・バイオシミラー学会

    ISSN： 1881-9117

  297. CHARACTERISTICS OF UNCONTROLLED HYPERTENSIVE PATIENTS DETERMINED BY MORNING AND EVENING HOME BLOOD PRESSURE MEASUREMENT FROM THE J-HOME STUDY

    T. Obara, K. Ito, T. Ohkubo, K. Gonokami, T. Shibamiya, T. Shinki, A. Hara, H. Metoki, K. Asayama, R. Inoue, M. Kikuya, N. Mano, Y. Imai

    JOURNAL OF HYPERTENSION　27　S259-S259　2009/06

    ISSN： 0263-6352

  298. HEART RATE, DOUBLE PRODUCT AND SHOCK INDEX IN PREGNANT WOMEN: THE BOSHI STUDY

    H. Metoki, T. Ohkubo, M. Kawaguchi, Y. Sato, A. Hara, T. Hirose, T. Obara, K. Asayama, M. Kikuya, K. Yagihashi, Y. Matsubara, K. Okamura, S. Mori, M. Suzuki, Y. Imai

    JOURNAL OF HYPERTENSION　27　S228-S228　2009/06

    ISSN： 0263-6352

  299. INFLUENCE OF HOME BLOOD PRESSURE MEASURING CONDITION IN EVENING ON THE MORNING-EVENING HOME BLOOD PRESSURE DIFFERENCE IN TREATED HYPERTENSIVE PATIENTS; THE J-HOME STUDY

    T. Obara, K. Ito, T. Ohkubo, K. Gonokami, T. Shibamiya, T. Shinki, M. Nakashita, A. Hara, H. Metoki, K. Asayama, R. Inoue, M. Kikuya, N. Mano, Y. Imai

    JOURNAL OF HYPERTENSION　27　S190-S190　2009/06

    ISSN： 0263-6352

  300. SERIAL CHANGE IN SELF-MEASURED BLOOD PRESSURE IN NORMAL PREGNANCY AND POSTPARTUM PERIOD: THE BOSHI STUDY

    M. Nishimura, H. Metoki, T. Ohkubo, Y. Watanabe, Y. Sato, M. Kawaguchi, A. Hara, T. Hirose, T. Obara, K. Yagihashi, Y. Matsubara, K. Okamura, S. Mori, M. Suzuki, Y. Imai

    JOURNAL OF HYPERTENSION　27　S182-S182　2009/06

    ISSN： 0263-6352

  301. The association between masked hypertension and waist circumference as an obesity-related anthropometric index for metabolic syndrome: the Ohasama study

    Kei Asayama, Atsushi Sato, Takayoshi Ohkubo, Akira Mimura, Katsuhisa Hayashi, Masahiro Kikuya, Daisaku Yasui, Atsuhiro Kanno, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION RESEARCH　32　(6)　438-443　2009/06

    DOI： 10.1038/hr.2009.37 　

    ISSN： 0916-9636

  302. リスク評価と治療計画 (特集 新高血圧治療ガイドラインの考え方)

    小原 拓, 今井 潤

    調剤と情報　15　(5)　482-487　2009/05

    Publisher: じほう

    ISSN： 1341-5212

  303. 家庭血圧・随時血圧とアディポサイトカインとの関連 大迫研究

    林 克剛, 浅山 敬, 大久保 孝義, 菊谷 昌浩, 三村 亨, 保坂 美樹, 原 梓, 小原 拓, 目時 弘仁, 井上 隆輔, 星 晴久, 佐藤 洋, 及川 眞一, 今井 潤

    日本循環器病予防学会誌　44　(2)　98-98　2009/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  304. 家庭血圧測定に基づくアムロジピンベシル酸塩の臨床評価 先発医薬品(普通錠2.5mg/5mg)から後発医薬品(アムロジピン錠2.5mg/5mg「明治」)への切り替え

    小原 拓, 池田 うらら, 芝宮 拓, 新木 貴大, 原 梓, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本薬学会年会要旨集　129年会　(4)　308-308　2009/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  305. Office and Out-of-Office Heart Rate and the Development of Metabolic Disorders

    Taku Obara, Takayoshi Ohkubo, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION　22　(2)　130-130　2009/02

    DOI： 10.1038/ajh.2008.350 　

    ISSN： 0895-7061

  306. 正常妊娠経過における家庭血圧推移と血圧季節変動 BOSHI研究

    目時 弘仁, 大久保 孝義, 渡邉 悠美子, 西村 美里, 佐藤 友里恵, 川口 麻衣子, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 八木橋 香津代, 岡村 州博, 松原 洋一, 森 滋, 鈴木 雅洲, 今井 潤

    日本妊娠高血圧学会雑誌　16　101-102　2008/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  307. 正常血圧妊婦における出産前後の自己測定血圧推移 BOSHI研究

    西村 美里, 目時 弘仁, 大久保 孝義, 渡邉 悠美子, 佐藤 友里恵, 川口 麻衣子, 八木橋 香津代, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 岡村 州博, 松原 洋一, 森 滋, 鈴木 雅洲, 今井 潤

    日本妊娠高血圧学会雑誌　16　172-173　2008/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  308. 正常血圧妊婦における高血圧家族歴と妊娠時の家庭血圧推移 BOSHI研究

    渡邉 悠美子, 目時 弘仁, 大久保 孝義, 西村 美里, 佐藤 友里恵, 川口 麻衣子, 八木橋 香津代, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 岡村 州博, 松原 洋一, 森 滋, 鈴木 雅洲, 今井 潤

    日本妊娠高血圧学会雑誌　16　174-175　2008/12

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  309. Seasonal trends of blood pressure during pregnancy in Japan: the Babies and their Parents&apos; Longitudinal Observation in Suzuki Memorial Hospital in Intrauterine Period study

    Hirohito Metoki, Takayoshi Ohkubo, Yumiko Watanabe, Misato Nishimura, Yurie Sato, Maiko Kawaguchi, Azusa Hara, Takuo Hirose, Taku Obara, Kei Asayama, Masahiro Kikuya, Katsuyo Yagihashi, Yoichi Matsubara, Kunihiro Okamura, Shigeru Mori, Masakuni Suzuki, Yutaka Imai

    JOURNAL OF HYPERTENSION　26　(12)　2406-2413　2008/12

    DOI： 10.1097/HJH.0b013e32831364a7 　

    ISSN： 0263-6352

  310. わが国の家庭血圧測定の現状と変化 医師の実践と意識"家庭血圧測定の現状に関する調査研究-2"

    小原 拓, 今井 潤, 大久保 孝義, 宮川 政昭

    日本高血圧学会総会プログラム・抄録集　31回　167-167　2008/10

    Publisher: (NPO)日本高血圧学会

  311. 家庭血圧測定と降圧薬使用 J-HOME研究およびJ-HOME追跡(Morning)研究より

    小原 拓, 大久保 孝義, 小林 満, 眞野 成康, 今井 潤

    薬剤疫学　13　(Suppl.)　S62-S63　2008/10

    Publisher: (一社)日本薬剤疫学会

    ISSN： 1342-0445

  312. 降圧治療と関連する遺伝因子のゲノムスキャン HOMED-BP-GENE研究

    勝谷 友宏, 浅山 敬, 大久保 孝義, 杉本 研, 井上 隆輔, 目時 弘仁, 小原 拓, 石川 一彦, 藤澤 智巳, 大石 充, 荻原 俊男, 今井 潤, 樂木 宏実

    日本高血圧学会総会プログラム・抄録集　31回　262-262　2008/10

    Publisher: (NPO)日本高血圧学会

  313. Home blood pressure measurement in large-scale clinical trials

    Japanese journal of clinical medicine　66　191-196　2008/10

    Publisher: 日本臨床社

    ISSN： 0047-1852

  314. 家庭血圧を用いた高血圧発症予測遺伝子多型の同定 大迫研究における12年の追跡から

    渡邉 悠美子, 目時 弘仁, 大久保 孝義, 勝谷 友宏, 田原 康玄, 菊谷 昌浩, 廣瀬 卓男, 杉本 研, 浅山 敬, 井上 隆輔, 原 梓, 小原 拓, 橋本 潤一郎, 名倉 潤, 小原 克彦, 戸恒 和人, 荻原 俊男, 樂木 宏実, 三木 哲郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　207-207　2008/10

    Publisher: (NPO)日本高血圧学会

  315. 正常妊娠経過における家庭血圧推移と血圧季節変動 BOSHI研究

    目時 弘仁, 大久保 孝義, 渡邉 悠美子, 西村 美里, 佐藤 友里恵, 川口 麻衣子, 八木橋 香津代, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 岡村 州博, 松原 洋一, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　359-359　2008/10

    Publisher: (NPO)日本高血圧学会

  316. 正常妊婦における出産前後の自己測定血圧推移 BOSHI研究

    西村 美里, 目時 弘仁, 大久保 孝義, 渡邉 悠美子, 佐藤 友里恵, 川口 麻衣子, 八木橋 香津代, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 岡村 州博, 松原 洋一, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　359-359　2008/10

    Publisher: (NPO)日本高血圧学会

  317. 正常妊婦における高血圧家族歴と妊娠時の血圧推移 BOSHI研究

    渡邉 悠美子, 目時 弘仁, 大久保 孝義, 西村 美里, 佐藤 友里恵, 川口 麻衣子, 八木橋 香津代, 原 梓, 廣瀬 卓男, 小原 拓, 浅山 敬, 菊谷 昌浩, 岡村 州博, 松原 洋一, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　31回　360-360　2008/10

    Publisher: (NPO)日本高血圧学会

  318. Genome-Wide Association Study for the Response to Antihypertensive Medication: HOMED-BP-GENE Study

    Tomohiro Katsuya, Kei Asayama, Ryusuke Inoue, Ken Sugimoto, Takayoshi Ohkubo, Hirohito Metoki, Taku Obara, Kazuhiko Ishiakwa, Tomomi Fujisawa, Mitsuru Ohishi, Toshio Ogihara, Yutaka Imai, Hiromi Rakugi

    CIRCULATION　118　(18)　S890-S890　2008/10

    ISSN： 0009-7322

  319. Home blood pressure values during normal pregnancy: First report of the babies and their parents&apos; longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI study)

    H. Metoki, T. Ohkubo, Y. Watanabe, M. Nishimura, K. Yagihashi, A. Hara, T. Hirose, T. Obara, M. Kikuya, K. Okamura, Y. Matsubara, S. Mori, M. Suzuki, Y. Imai

    JOURNAL OF HYPERTENSION　26　S17-S17　2008/06

    ISSN： 0263-6352

  320. 長時間作用型Ca拮抗薬ニルバジピンの家庭血圧および血圧日間変動に与える影響(MORNING study)

    加藤 哲夫, 小原 拓, 菊谷 昌浩, 田中 宏治, 原 梓, 後ノ上 健太, 目時 弘仁, 大久保 孝義, 今井 潤

    血圧　15　(5)　427-433　2008/05

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    長時間作用型Ca拮抗薬であるニルバジピン投与が血圧日間変動に与える影響について検討した。ニルバジピンの早朝高血圧に対する影響を検討した大規模多施設共同研究として行った。早朝血圧解析対象者318例のうち、就床前血圧が得られた229例を就床前血圧に関する解析対象者とした。ニルバジピン投与により家庭血圧の有意な降圧を認めた。日間変動高値群においては、ニルバジピン投与により血圧日間変動の有意な減少を認めた。ニルバジピン投与により、早朝高血圧者の早朝血圧は有意に低下し、早朝高血圧者における早朝血圧を効果的に抑制させる薬剤であることが示唆された。ニルバジピン4mgまたは8mg投与により、それぞれ有意な家庭血圧の降圧を認めた。1日1回朝または晩投与および1日2回朝晩投与のいずれの服用方法でも、有意な降圧が得られることが示された。

  321. 家庭血圧に基づく仮面高血圧・白衣高血圧と、ウエスト周囲径ならびにBMIに関する横断的検討 大迫研究

    佐藤 敦, 浅山 敬, 大久保 孝義, 菊谷 昌浩, 三村 享, 原 梓, 小原 拓, 目時 弘仁, 井上 隆輔, 星 晴久, 佐藤 洋, 坂本 尚夫, 今井 潤

    日本循環器病予防学会誌　43　(1)　39-39　2008/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  322. 患者の服薬コンプライアンスに影響を与える因子に関する薬剤師の認識

    小原 拓, 田中 宏治, 生出 泉太郎, 小林 満, 原 梓, 高橋 則男, 高橋 將喜, 大久保 孝義, 今井 潤

    日本薬学会年会要旨集　128年会　(4)　176-176　2008/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  323. Proposal of a risk-stratification system for the Japanese population based on blood pressure levels: the Ohasama study.

    Asayama Kei, Ohkubo Takayoshi, Sato Atsushi, Hara Azusa, Obara Taku, Yasui Daisaku, Metoki Hirohito, Inoue Ryusuke, Kikuya Masahiro, Hashimoto Junichiro, Hoshi Haruhisa, Satoh Hiroshi, Imai Yutaka

    Hypertens Res　31　(7)　1315-1322　2008

    DOI： 10.1291/hypres.31.1315 　

    ISSN： 0916-9636 1348-4214

  324. Questionnaire on the awareness of generic products among outpatients

    Japanese journal of generic medicines　1　(2)　92-101　2007/12

    Publisher: 日本ジェネリック医薬品学会

    ISSN： 1881-9117

  325. 大迫研究(家庭血圧の重要性を世界に発信した) 家庭血圧測定の活用

    小原 拓, 大久保 孝義, 今井 潤

    BIO Clinica　22　(11)　996-1000　2007/10

    Publisher: (株)北隆館

    ISSN： 0919-8237

  326. 一般地域住民における一般用医薬品・サプリメント使用に関する実態調査

    原 梓, 大久保 孝義, 菊谷 昌浩, 佐藤 理恵, 小原 拓, 宇津木 恵, 目時 弘仁, 佐藤 洋, 今井 潤

    Health Sciences　23　(4)　303-303　2007/10

    Publisher: 日本健康科学学会

    ISSN： 0911-7024

  327. How many times should we ask subjects to measure blood pressure at home on each occasion?

    Yutaka Imai, Taku Obara, Takayoshi Ohkubo

    JOURNAL OF HYPERTENSION　25　(10)　1987-1991　2007/10

    ISSN： 0263-6352

  328. 両親の長寿は子の低い血圧と関連する 大迫研究

    渡邉 悠美子, 目時 弘仁, 大久保 孝義, 廣瀬 卓男, 菊谷 昌浩, 浅山 敬, 井上 隆輔, 森戸 里衣子, 原 梓, 小原 拓, 星 晴久, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集　30回　271-271　2007/10

    Publisher: (NPO)日本高血圧学会

  329. Stroke Risk in Systolic and Combined Systolic and Diastolic Hypertension Determined Using Ambulatory Blood Pressure. The Ohasama Study

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    American Journal of Hypertension　20　(10)　1125-1131　2007/10

    DOI： 10.1016/j.amjhyper.2007.04.017 　

    ISSN： 0895-7061

  330. 29-A3-14-5 降圧薬服用コンプライアンス不良者の特性及び生活習慣に関する研究(調剤・服薬指導・薬剤管理指導,社会の期待に応える医療薬学を)

    原 梓, 大久保 孝義, 菊谷 昌浩, 小原 拓, 田中 宏治, 目時 弘仁, 宇津木 恵, 井上 隆輔, 浅山 敬, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本医療薬学会年会講演要旨集　17　190-190　2007/09/01

    Publisher: 日本医療薬学会

  331. Definition of masked hypertension

    Taku Obara, Takayoshi Ohkubo, Kei Asayama, Hirohito Metoki, Yutaka Imai

    JOURNAL OF HYPERTENSION　25　(7)　1511-1512　2007/07

    ISSN： 0263-6352

  332. Usefulness of the vasodilator minoxidil in resistant hypertension - Reply

    Taku Obara, Takayoshi Ohkubo, Takuya Oikawa, Yutaka Imai

    JOURNAL OF HYPERTENSION　25　(5)　1103-1103　2007/05

    ISSN： 0263-6352

  333. Plasma fibrinogen, ambulatory blood pressure, and silent cerebrovascular lesions: The Ohasama study

    Yoko Aono, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Takeo Kondo, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoriko Shintani, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

    Arteriosclerosis, Thrombosis, and Vascular Biology　27　(4)　963-968　2007/04

    DOI： 10.1161/01.ATV.0000258947.17570.38 　

    ISSN： 1079-5642

  334. Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality in Ohasama, Japan

    Masahiro Kikuya, Jan A. Staessen, Takayoshi Ohkubo, Lutgarde Thijs, Hirohito Metoki, Kei Asayama, Taku Obara, Ryusuke Inoue, Yan Li, Eamon Dolan, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Ji-Guang Wang, Eoin O'Brien, Yutaka Imai

    Stroke　38　(4)　1161-1166　2007/04

    DOI： 10.1161/01.STR.0000259604.67283.69 　

    ISSN： 0039-2499

  335. 高血圧患者における服薬コンプライアンスの現状

    田中 宏治, 生出 泉太郎, 小原 拓, 高橋 將喜, 高橋 則男, 大久保 孝義, 今井 潤

    日本薬学会年会要旨集　127年会　(3)　94-94　2007/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  336. GEの競争政策上の評価 (特集 ジェネリック医薬品(GE)の到来--GEを理解するために) -- (GEにおける医療経済と医療制度)

    小原 拓, 小林 慎

    治療　89　(3)　527-531　2007/03

    Publisher: 南山堂

    ISSN： 0022-5207

  337. Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study

    Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takanao Hashimoto, Toshiya Harasawa, Yoko Aono, Harunori Otani, Kazushi Tanaka, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    Journal of Hypertension　25　(2)　321-327　2007/02

    DOI： 10.1097/HJH.0b013e3280115bbf 　

    ISSN： 0263-6352

  338. The current status of heart rate measured at home among treated hypertensive patients: The Japan home versus office blood pressure measurement evaluation (J-HOME) study

    Rie Komai, Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Takuya Oikawa, Kayo Murai, Tsuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　266-266　2006/12

    ISSN： 0263-6352

  339. Ambulatory blood pressure, blood pressure variability and the prevalence of carotid atherosclerosis: The ohasama study

    Yoriko Shintani, Masahiro Kikuya, Azusa Haral, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Yoko Aono, Takanao Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　122-123　2006/12

    ISSN： 0263-6352

  340. Development of new electronic drug compliance-monitoring device for one dose package (HCM-100)

    Taku Obara, Takayoshi Ohkubo, Kayo Murai, Rie Komai, Kouji Tanaka, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　220-220　2006/12

    ISSN： 0263-6352

  341. Ambulatory blood pressure, plasma fibrinogen, and silent cerebrovascular lesions: The ohasama study

    Yoko Aono, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Takeo Kondo, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoriko Shintani, Junichiro Hashirnoto, Kazuhito Totsune, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　212-212　2006/12

    ISSN： 0263-6352

  342. Cost-effectiveness of home blood pressure

    Hidefumi Fukunaga, Takayoshi Ohkubo, Taku Obara, Miwa Nakagawa, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Makoto Kobayashi, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　87-88　2006/12

    ISSN： 0263-6352

  343. Comparison of stroke risk among subtypes of hypertension determined by 24-hour ambulatory blood pressure monitoring: The Ohasama study

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　117-117　2006/12

    ISSN： 0263-6352

  344. Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality: Results from the ohasama study

    Masahiro Kikuya, Jan A. Staessen, Takayoshi Ohkubo, Lutgarde Thijs, Hirohito Metoki, Kei Asayama, Taku Obara, Ryusuke Inoue, Yan Li, Eamon Dolan, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　171-171　2006/12

    ISSN： 0263-6352

  345. Detection of silent cerebrovascular lesions in subjects with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study

    Azusa Hara, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Yoko Aono, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoriko Shintani, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　267-267　2006/12

    ISSN： 0263-6352

  346. Factors affecting day-by-day variability of self-measured blood pressure at home: The Ohasama study

    Tetsuo Kato, Masahiro Kikuya, Takayoshi Ohkubo, Azusa Hara, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Satoh Hiroshi, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　87-87　2006/12

    ISSN： 0263-6352

  347. Home and office blood pressure control among elderly hypertensive patients without calcium channel blockers before and after JSH2004

    Taku Obara, Takayoshi Ohkubo, Rie Komai, Kayo Murai, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　379-379　2006/12

    ISSN： 0263-6352

  348. The current usage of diuretics among hypertensive patients in Japan: the Japan home versus office blood pressure measurement evaluation (J-HOME) study

    Kayo Murai, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Masahiro Kikuya, Ryusuke Inoue, Kei Asayama, Takuya Oikawa, Rie Komai, Tuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　260-260　2006/12

    ISSN： 0263-6352

  349. Parental longevity and home blood pressure values in adult offspring: The Ohasama study Peer-reviewed

    Metoki Hirohito, Ohkubo Takayoshi, Watanabe Yumiko, Hirose Takuo, Kikuya Masahiro, Asayama Kei, Inoue Ryusuke, Hara Azusa, Obara Taku, Hoshi Haruhisa, Hashimoto Junichiro, Totsune Kazuhito, Imai Yutaka

    JOURNAL OF HYPERTENSION　24　241　2006/12

    ISSN： 0263-6352

  350. Combination of decreased kidney function and pre-hypertension affect mortality risk in a general Japanese population: The Ohasama study Peer-reviewed

    Metoki Hirohito, Ohkubo Takayoshi, Nakayama Msaaki, Terawaki Hiroyuki, Kikuya Masahiro, Asayama Kei, Hara Azusa, Hirose Takuo, Obara Taku, Hashimoto Junichiro, Totsune Kazuhito, Hoshi Haruhisa, Ito Sadayoshi, Imai Yutaka

    JOURNAL OF HYPERTENSION　24　78-79　2006/12

    ISSN： 0263-6352

  351. Predicting stroke using 4 ambulatory blood pressure monitoring-derived blood pressure indices: The Ohasama study

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    Hypertension　48　(5)　877-882　2006/11

    DOI： 10.1161/01.HYP.0000242285.83728.ee 　

    ISSN： 0194-911X

  352. Introversion associated with large differences between screening blood pressure and home blood pressure measurement: The Ohasama study

    Atsushi Hozawa, Takayoshi Ohkubo, Taku Obara, Hirohito Metoki, Masahiro Kikuya, Kei Asayama, Kazuhito Totsune, Junichiro Hashimoto, Haruhisa Hoshi, Yumiko Arai, Hiroshi Satoh, Toru Hosokawa, Yutaka Imai

    Journal of Hypertension　24　(11)　2183-2189　2006/11

    DOI： 10.1097/01.hjh.0000249695.81241.35 　

    ISSN： 0263-6352

  353. 一般地域住民におけるサプリメント摂取者の人口学的特性及び生活習慣に関する研究

    原 梓, 大久保 孝義, 菊谷 昌浩, 小原 拓, 芝崎 貴子, 目時 弘仁, 井上 隆輔, 浅山 敬, 橋本 潤一郎, 戸恒 和人, 星 晴久, 細川 徹, 佐藤 洋, 今井 潤

    Health Sciences　22　(4)　606-606　2006/10

    Publisher: 日本健康科学学会

    ISSN： 0911-7024

  354. Prognostic significance of night-time, early morning, and daytime blood pressures on the risk of cerebrovascular and cardiovascular mortality: The Ohasama Study

    Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Taku Obara, Azusa Hara, Takuo Hirose, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    Journal of Hypertension　24　(9)　1841-1848　2006/09

    DOI： 10.1097/01.hjh.0000242409.65783.fb 　

    ISSN： 0263-6352

  355. 高血圧患者における心拍数管理の重要性とβ遮断薬の使用実態 大迫研究,J-HOME(The Japan Home vs.Office blood pressure Measurement Evaluation)研究からの考察

    小原 拓, 駒井 理恵, 大久保 孝義, 今井 潤

    血圧　13　(8)　921-927　2006/08

    Publisher: (株)先端医学社

    ISSN： 1340-4598

  356. 治療中高齢高血圧患者における家庭血圧管理の現状 J-HOME研究グループを代表して

    小原 拓, 大久保 孝義, 今井 潤

    日本老年医学会雑誌　43　(Suppl.)　132-132　2006/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  357. 家庭血圧重視の立場から (診療controversy--medical decision makingのために 家庭血圧と24時間血圧を高血圧診療にどのように生かすか?)

    芝崎 貴子, 小原 拓, 今井 潤

    内科　97　(5)　901-905　2006/05

    Publisher: 南江堂

    ISSN： 0022-1961

  358. Masked hypertension and white-coat hypertension prognosis - Reply

    T Ohkubo, M Kikuya, H Metoki, K Asayama, T Obara, J Hashimoto, K Totsune, H Hoshi, H Satoh, Y Imai

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　47　(10)　2127-2128　2006/05

    DOI： 10.1016/j.jacc.2006.02.035 　

    ISSN： 0735-1097

  359. Prognosis of "masked" hypertension vs "white-coat" hypertension

    Takayoshi Ohkubo, Takayoshi Ohkubo, Takayoshi Ohkubo, Masahiro Kikuya, Masahiro Kikuya, Hirohito Metoki, Hirohito Metoki, Hirohito Metoki, Kei Asayama, Kei Asayama, Kei Asayama, Taku Obara, Taku Obara, Junichiro Hashimoto, Junichiro Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Kazuhito Totsune, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Hiroshi Satoh, Hiroshi Satoh, Yutaka Imai

    Cardiology Review　23　23-27　2006/04/01

    ISSN： 1092-6607

  360. 一包化調剤対応服薬コンプライアンス計(HCM-100)の開発

    駒井 理恵, 小原 拓, 大久保 孝義, 村井 華代, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本薬学会年会要旨集　126年会　(2)　158-158　2006/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  361. PJ-544 Effectiveness of Nilvaldipine for Morning Hypertension by Home Blood Pressure (MORNING Study)(Hypertension, clinical-8 (M) PJ92,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

    Ohkubo Takayoshi, Obara Taku, Asayama Kei, Metoki Hirohito, Hashimoto Junichiro, Imai Yutaka

    Circulation journal : official journal of the Japanese Circulation Society　70　624-624　2006/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  362. Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline: The Ohasama study

    Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    Hypertension　47　(2)　149-154　2006/02

    DOI： 10.1161/01.HYP.0000198541.12640.0f 　

    ISSN： 0194-911X

  363. White-coat hypertension and progression to home hypertension

    Takashi Ugajin, Atsushi Hozawa, Takayoshi Ohkubo, Takayoshi Ohkubo, Kei Asayama, Kei Asayama, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Hirohito Metoki, Haruhisa Hoshi, Junichiro Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Satoh, Ichiro Tsuji, Yutaka Imai, Yutaka Imai

    Cardiology Review　23　18-22　2006/02/01

    ISSN： 1092-6607

  364. 家庭血圧によるニルバジピン(ニバジール)の早朝高血圧に対する有用性の検討 MORNING study

    小原 拓, 大久保 孝義, 芝崎 貴子, 菊谷 昌浩, 今井 潤

    Therapeutic Research　27　(1)　99-114　2006/01

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

  365. 家庭血圧測定の意義 (特集 高血圧--管理と予防)

    小原 拓, 今井 潤

    セフィーロ　(4)　38-41　2006

    Publisher: メデカジャパン・ラボラトリー

    ISSN： 1880-5167

  366. Prognosis of "masked" hypertension and "white-coat" hypertension detected by 24-h ambulatory blood pressure monitoring: 10-Year follow-up from the Ohasama study

    Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    Journal of the American College of Cardiology　46　(3)　508-515　2005/08/02

    DOI： 10.1016/j.jacc.2005.03.070 　

    ISSN： 0735-1097

  367. Isolated uncontrolled hypertension at home and in the office among treated hypertensive patients from the J-home study

    T Obara, T Ohkubo, J Funahashi, M Kikuya, K Asayama, H Metoki, T Oikawa, J Hashimoto, K Totsune, Y Imai

    JOURNAL OF HYPERTENSION　23　S34-S34　2005/06

    ISSN： 0263-6352

  368. Isolated Uncontrolled Hypertension at Home and in the Office among Treated Hypertensive Patients : from the J-HOME Study(Hypertension, Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Obara Taku, Ohkubo Takayoshi, Asayama Kei, Metoki Hirohito, Hashimoto Junichiro, Imai Yutaka

    Circulation journal : official journal of the Japanese Circulation Society　69　267-268　2005/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  369. Prognostic Significance of Night-time, Early Morning and Daytime Blood Pressures on the Risks of Cerebro and Cardiovascular Mortality(Hypertension, Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Metoki Hirohito, Ohkubo Takayoshi, Asayama Kei, Obara Taku, Hashimoto Junichiro, Imai Yutaka

    Circulation journal : official journal of the Japanese Circulation Society　69　268-269　2005/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  370. Ambulatory blood pressure and 10-year risk of cardiovascular and noncardiovascular mortality: The Ohasama study

    Masahiro Kikuya, Takayoshi Ohkubo, Kei Asayama, Hirohito Metoki, Taku Obara, Shin Saito, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    Hypertension　45　(2)　240-245　2005/02

    DOI： 10.1161/01.HYP.0000152079.04553.2c 　

    ISSN： 0194-911X

  371. Plasma Fibrinogen and Silent Cerebrovascular Lesions

    Aono Yoko, Kikuya Masahiro, Hara Azusa, Ohkubo Takayoshi, Kondo Takeo, Asayama Kei, Inoue Ryusuke, Metoki Hirohito, Obara Taku, Shintani Yoriko, Hashimoto Junichiro, Totsune Kazuhito, Hoshi Haruhisa, Satoh Hiroshi, Izumi Shin-Ichi, Imai Yutaka

    Japanese Journal of Cardiovascular Disease Prevention　40　(3)　181-189　2005

    Publisher: 社団法人 日本循環器管理研究協議会

    DOI： 10.11381/jjcdp2001.40.181 　

    ISSN： 1346-6267

    More details Close

    [Background and purpose] Silent cerebrovascular lesions are associated with an increased risk of stroke. Although the incidence of cerebral hemorrhage has decreased in Japan, prevalence of cerebral infarction has not decreased. Fibrinogen is a major determinant of plasma viscosity. It is possible that elevated fibrinogen level is associated with the risk of cerebral infarction. We conducted a cross-sectional study to determine the association between plasma fibrinogen and cerebrovascular lesions in a general population.&lt;BR&gt;[Methods] The study population consisted of 662 subjects (32.2% men, mean age 66.6 ± 5.3 years, mean plasma fibrinogen 299.8 ± 63.5 mg/dl) from a general population of rural Japanese community, Ohasama. We evaluated the association between plasma fibrinogen and silent cerebrovascular lesions [number of lacunar infarction and extent of periventricular hyperintensity (PVH)] detected by MRI.&lt;BR&gt;[Results] Fibrinogen levels were significantly higher in subjects with multiple lacunar infarctions. Each 1SD (63.5 mg/dl) increase in fibrinogen was significantly associated with an increase in the risk of lacunar infarction (OR=1.29, 95% CI : 1.09-1.53) after adjustment for age, sex, smoking status, drinking status, use of antihypertensive medication, BMI, 24-h ambulatory blood pressure (24-h ABP), and a history of hypercholesterolemia, diabetes mellitus or atrial fibrillation. Twenty-four hour ABP was also significantly and independently associated with lacunar infarction. Even when 24-h ABP values were within the normal range (&lt;135/80 mmHg), elevated fibrinogen levels were associated with an increased risk of lacunar infarction. There was no association between fibrinogen and PVH.&lt;BR&gt;[Conclusion] The present results demonstrated that fibrinogen was strongly associated with risk of lacunar infarction, suggesting that fibrinogen is an independent risk factor or predictor for lacunar infarction.

  372. 【白衣高血圧と仮面高血圧】 白衣高血圧,仮面高血圧の定義と頻度

    小原 拓, 大久保 孝義, 今井 潤

    血圧　11　(8)　783-787　2004/08

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    白衣性高血圧および仮面高血圧は日常診療においてしばしば見かけられるものである.しかし,仮面高血圧患者に関しては医療環境下血圧が正常範囲であるために,非医療環境下の高血圧がマスクされ,種々の合併症・将来の脳心血管疾患発症リスクが見逃されている可能性が考えられる.日常診療においては,比較的簡便な家庭血圧測定の導入により,白衣性高血圧患者および仮面高血圧患者を見逃さないよう注意することが,患者の将来の脳心血管疾患発症を予防するうえで非常に重要である

Show all ︎Show first 5

Research Projects 15

  1. Comprehensive Omics Profiling of Placenta Previa Utilizing Biobank Resources for Clinical Translation

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2025/04/01 - 2029/03/31

  2. Study for the relationship between Infertility treatment, hypertension in pregnancy and child health

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2024/04/01 - 2028/03/31

  3. Strategies to prevent Medication-Related Osteonecrosis of the Jaw focusing on the CXCR4 system and oral microbiome

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Hamamatsu University School of Medicine

    2024/04/01 - 2027/03/31

  4. 家族歴・産科合併症既往を考慮した高血圧等の母児の予後の検討

    石黒 真美, 目時 弘仁, 小原 拓

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

    More details Close

    本研究では、全国規模の医療情報データベース及び三世代に渡る家族参加型の出生ゲノムコホート研究を用いて、妊娠高血圧症候群、妊娠糖尿病、妊娠中の脂質異常症の要因および母児の予後への影響を明らかにすることを目的としている。 2021年度は、東北メディカル・メガバンク計画三世代コホート調査のデータを基に、妊娠高血圧症候群の既往と産後約3年での血圧値との関連を検討した。共分散分析の結果、妊娠高血圧症候群既往のある女性は、既往のない女性に比べて、産後3年での血圧値が高かった。多変量ロジスティック回帰分析でも、妊娠高血圧症候群の既往は、産後3年での高血圧との関連も認めた（オッズ比5.67、95 %信頼区間4.34-7.41）。また、初産婦、経産婦で妊娠高血圧症候群既往なし、既往ありの3群にわけ、それぞれの群において直近の妊娠中の妊娠高血圧症候群を発症有無で産後の血圧値を比較したところ、いずれの群でも直近の妊娠中に妊娠高血圧症候群を発症した女性の方が産後3年での血圧値が高かった。しかしながら、過去に妊娠高血圧症候群の既往がある女性は、直近の妊娠中に妊娠高血圧症候群を発症しなかったとしても、既往のない経産婦と比較すると血圧値が高かったことから、妊娠高血圧症候群の発症回数に関わらず、妊娠高血圧症候群発症そのものが産後数年での血圧値や高血圧に影響する可能性が示唆された。 全国規模の医療情報データベースにおいても、構造の理解を深め、両親の高血圧有病状況と子どもの高血圧有病状況の関連について検討を進めた。

  5. 降下性縦隔炎の治療法構築と地域包括医療計画への提言：医療ビッグデータを用いた解析

    日高 浩史, 岩井 大, たら澤 邦男, 藤森 研司, 小原 拓, 阪上 智史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 関西医科大学

    2020/04/01 - 2023/03/31

    More details Close

    深頸部感染症は降下性縦隔炎や敗血症など致死的な合併症や、嚥下機能回復が遅延することがある。今回、医療大規模データを用いて全国レベルでの深頸部感染症における生命予後、術後の経口摂取回復が遅延する因子について分析した。 2012～6年のDPCデータベースからスクリーニングを行い、4949例に対し、死亡退院に関与するリスクについてロジステック回帰分析を行った。さらに生存退院した4791例に対し、経口 摂取回復が遅延する因子について解析した。 年齢（75歳以上）、人工呼吸器使用と抗菌薬の使用期間の3つのみが、2つのアウトカムともに統計学的に有意なリスク因子であった。一方、縦隔炎合併、複数回の排膿術は経口摂取回復遅延に対してのみ有意な因子であった。 近年、胸腔鏡での排膿術を併用することで、降下性縦隔炎の生存率が向上していると予想されるが、組織の瘢痕などで嚥下機能回復が遅延するリスクを踏まえ た治療プランニングが必要と考えられる。本研究成果は、欧文誌Head and Neckに掲載された（Hidaka H, et al: Identification of risk factors for mortality and delayed oral dietary intake in patients with open drainage due to deep neck infections: Nationwide study using a Japanese inpatient database. Head Neck. 43(7):2002-2012, 2021)。

  6. 小児における向精神薬使用の安全性評価の推進

    小原 拓

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2019/04/01 - 2022/03/31

    More details Close

    株式会社JMDCが保有する健康保険組合のClaims Databaseに基づいて、小児における注意欠如・多動性障害（ADHD）に対する治療薬であるメチルフェニデート徐放錠：OROS-MPH、アトモキセチン；ATX）と心血管系疾患リスクとの関連を推定することを目的に、7,773人の小児を対象とした後ろ向きコホート研究を実施してきた。これまでに、心筋梗塞、脳卒中、不整脈、高血圧症などをアウトカムとするCOX比例ハザードモデル解析によって、ADHD治療薬処方群における心血管系イベントのリスクが高値であったことなどを明らかにした。更に、アウトカムの一つである不整脈の重症度を考慮した感度解析を行い、対象者数が減少したものの、いずれの感度解析においてもハザード比の点推定値は1を超えており、ADHD治療薬処方群で不整脈と正に関連していた。 株式会社Medical Data Visionが保有するDPC病院のAdministrative Databaseに基づいて、てんかんの小児外来患者（0～17歳）に対する抗てんかん薬の処方動向を評価した。女児では、バルプロ酸とカルバマゼピンがそれぞれ37.9％から26.8％、24.8％から15.8％に減少し、逆にレベチラセタムの処方の割合は6.4%から28.2%に増加していた。男児では、バルプロ酸とカルバマゼピンがそれぞれ36.6％から32.2％、26.4％から16.9％に減少し、レベチラセタムの処方比率は5.6%から23.0%に増加していた。全体としてバルプロ酸とカルバマゼピンの処方割合は減少し、レベチラセタムの処方割合が増加していた。日本の小児てんかん外来患者における抗てんかん薬処方の傾向は、より最近に発売された抗てんかん薬にシフトしていることが明らかとなった。

  7. Maternal use of pharmaceuticals during pregnancy and congenital malformations in offspring.

    Nishigori Hidekazu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Fukushima Medical University

    2019/04/01 - 2022/03/31

    More details Close

    We used a large administrative claim database to examine the use of pharmaceuticals by pregnant women and the development of their offspring. The dates of pregnancy onset and delivery were estimated using the developed algorithms. More than 30,000 pregnant women were registered in the administrative claim database. We found no significant association between the major congenital malformations of the offspring and (1) early pregnancy prescriptions of propulsive with domperidone, (2) early pregnancy prescriptions of antihypertensive agents including amlodipine and methyldopa, and (3) early pregnancy prescriptions of calcineurin inhibitors, which are immunosuppressive drugs.

  8. Elucidation of autism etiology by combination of phenotype clustering and high-dimensional variables selection method

    KURIYAMA SHINICHI, Yamanaka Chizuru, Matsubara Hiroko, Nagai Masato, Obara Taku

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

    More details Close

    We investigated whether machine learning methods could potentially identify a subgroup of persons with autism spectrum disorder (ASD) who show vitamin B6 responsiveness by selected phenotype variables. We analyzed the existing data from our intervention study with 17 persons. The affinity propagation analysis showed good classification of three potential vitamin B6-responsive persons with ASD. The k-medoids analysis also showed good classification. We show a two-step genome-wide association study (GWAS). In the first step, we observed no significant associations in a GWAS including 597 cases and 370 controls. In the second step, we conducted a cluster analysis using k-means with 15 clusters based on Autism Diagnostic Interview-Revised (ADI-R) scores and history of vitamin treatment. We then conducted GWAS by each subgroup of cases vs all controls (cluster-based GWAS) and identified significant associations with 93 chromosomal loci that satisfied the genome-wide significance threshold.

  9. The assessment of the effectiveness and safety of seasonal influenza vaccine among Japanese pregnant women and children

    OBARA Taku

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

    More details Close

    In Japan, information on the effectiveness and safety of seasonal influenza vaccine among pregnant women and infants has not been available, differently from foreign countries. The aim of the present study was to evaluate the efficacy and safety of injection of influenza vaccine among pregnant women and infants in Japan based on the established study basements. In the babies' and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI) study and the Japan Environment and Children's Study (JECS), we completely collected the information on the injection of influenza vaccination among pregnant women and continued the follow-up survey for infants. We also clarified that the prevalence of infants who received influenza vaccine, that of infected by influenza virus, and had an experience of adverse drug reaction by influenza vaccination were not different between influenza seasons from 2015 to 2017.

  10. Surveys of novel risk factors for perinatal depression: A large-scale cohort epidemiological research project and a claims data-based study in Japan.

    NISHIGORI Hidekazu, KURIYAMA Shinichi, YOSHIDA Keiko, YAEGASHI Nobuo, OBARA Taku, NISHIGORI Toshie, SUGAWARA Junichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

    More details Close

    In coastal areas of Miyagi and Iwate, damaged by the 2011 Great East Japan Earthquake,exposure to tsunami, the destruction of homes and dissatisfaction with living conditions were more likely to cause perinatal depression in women who delivered after the disaster.Percentage of women who gave birth and their spouses with scores ≧9 on the Edinburgh Postnatal Depression Scale 1 month post discharge were 11.8% and 8.4%, respectively, and with scores ≧7 on the Mother-Infant Bonding Scale 1 month post discharge were 3.5% and 6.3%, respectively. The study evaluated the claims data of 8020 pregnant women from the Japan Medical Data Center. Percentage of prescription rates of psychotropic drugs is 3.43% during perinatal term, 10.3% within 7 days of delivery, and 0.59% for postnatal within a year.

  11. The association between dietary supplementation during pregnancy and conditions of pregnancy, infant growth, and development of diseases among mothers and children

    OBARA Taku

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

    More details Close

    The objective of this study was to clarify the association between dietary supplementation during pregnancy and conditions of pregnancy, infant growth, and development of diseases among mothers and children. Participants in the JECS additional study and those who participated in the BOSHI study was most frequently used folic acid supplement during pregnancy (20.2－35.4％), followed by mineral and vitamin B. We established the research infrastructure to clarify the association between dietary supplementation during pregnancy and conditions of pregnancy, infant growth, and development of diseases among mothers and children.

  12. 脳心血管疾患危険因子に対する薬物治療の医療薬学・経済学的検討

    小原 拓

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 東北大学

    2008 - 2010

    More details Close

    降圧治療中患者に関する追跡研究(J-HOME-Morning/Elderly研究)は、最終的な追跡率が80%を超え、すでに回収・データ入力を終えていた1次・2次調査の結果は、「降圧治療中患者における家庭血圧管理と腎機能低下に関する縦断的検討:J-HOME-Morning研究」との演題名で発表した。また、今年は、日本全国の降圧治療中患者の家庭血圧管理状況と脳心血管疾患の発症・死亡の関連について報告する。高血圧治療の第一選択薬および家庭血圧の降圧目標に関する大規模介入試験であるHOMED-BP研究は、2010年5月で登録患者の追跡期間を終了とし、対象者の約94%の予後に関する情報が得られた。家庭血圧値に基づく降圧治療における降圧目標に関する最終結果を、2011年の第33回日本高血圧学会総会において報告する。その他、既存研究の基盤に基づいて、慢性疾患治療薬に関する医療薬学的研究を行い、順調に結果の発表及び論文化を行った。 慢性疾患に対する治療に関する情報に基づいて、医療経済的評価を行うという新規研究については、東北大学病院の処方履歴およびレセプトデータの利用手続きが間に合わなかったため、アンジオテンシンII受容体拮抗薬(ARB)高用量群とARBと利尿薬の合剤群で家庭血圧の降圧効果を比較したJ-HOME-AI研究のデータを用いて、薬剤経済学的検討を行い、ARB高用量を用いる治療に比べて、合剤による高血圧治療は、生存年数を短縮させることなく医療費の削減につながることを明らかにした。

  13. 仮面高血圧の頻度、治療･予後 Competitive

    System: 保健医療分野における基礎研究推進事業

    2003 - 2008

  14. The prevalence treatment, act prognosis of masked hypertension Competitive

    System: Basic Research Promotion Service for Health and Medical Field

    2003 - 2008

  15. 降圧治療中の高血圧患者における血圧管理および降圧薬使用と予後に関する追跡研究

    小原 拓

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 東北大学

    2006 - 2007

    More details Close

    2003年に行われた横断的調査(J-HOME研究)より、家庭血圧測定を行っている高血圧患者の血圧管理が、そのほかの高血圧患者に比べ良好であったことや、家庭血圧同様、予後予測能が高いことが報告されている早朝・就寝前家庭心拍数の規定因子、外的刺激に対する反応性の指標の一つである白衣現象(外来血圧-家庭血圧)の規定因子を明らかにし、英文雑誌に報告した。 また、第一次調査対象者のベースラインデータを固定し、ベースラインにおける対象者の外来血圧および家庭血圧管理状況、脳心血管疾患発症リスク因子、服用降圧薬剤の数・種類、および12誘導心電図所見に関する横断的検討を行い、その一部にあたる、高齢者高血圧患者の各種血圧管理状況等を欧州高血圧学会において発表した。また、2003年に行われた横断的調査(J-HOME研究)対象者との比較により、日本高血圧学会による高血圧治療ガイドライン(JSH2004)発表後の降圧薬使用状況、対象者の外来血圧・家庭管理状況、および患者の血圧管理状況に対する主治医の認識の変化を検討し、JSH2004発表後に、服用降圧薬数は増加し、各種血圧管理は改善し、患者の血圧に対する主治医の評価は、JSH2004発表後に厳格化しており、厳格な降圧を推奨したJSH2004が医療現場の降圧治療に影響している可能性を、日本高血圧学会で発表し、本報告は高得点演題に選出された。現在、JSH2004が日本の高血圧治療に与えた影響について、論文作成中である。 さらに、2006年10月より開始されていた第二次調査の終了に伴い、第二次調査において報告された各種イベントに関する詳細なイベント調査を開始すると同時に、第二次調査の結果をニュースレターとして参加施設ヘフィードバックし、2008年夏に開始予定の第三次調査へのモチベーションの維持に努めた。

Show all Show first 5