東北大学研究者紹介 - 島田　佐登志

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顔写真

シマダ　サトシ

島田　佐登志

Satoshi Shimada

所属

病院　内科　腎臓・高血圧内科

職名

助教

学位

博士（医学）（東北大学）

researchmap

https://researchmap.jp/sato_shima

J-GLOBAL ID

202501002602115793

e-Rad 研究者番号

11030627

ORCID

https://orcid.org/0000-0001-5293-572X

経歴 6

2026年6月～継続中

東北大学　病院（医科診療部門）腎臓・高血圧内科　助教
2024年7月～ 2026年5月

ウィスコンシン医科大学　生理学分野　講師
2018年6月～ 2026年5月

東北大学　病院（医科診療部門）腎・高血圧・内分泌科　非常勤講師
2018年6月～ 2024年6月

ウィスコンシン医科大学　生理学分野　ポストドクトラルリサーチフェロー
2015年4月～ 2018年5月

東北大学　病院（医科診療部門）腎・高血圧・内分泌科　非常勤医員（大学院）
2013年4月～ 2015年3月

みやぎ県南中核病院　初期研修医

︎全件表示 ︎最初の5件までを表示

学歴 2

東北大学　大学院医学系研究科

2015年4月～ 2019年3月
東北大学　医学部　医学科

2007年4月～ 2013年3月

委員歴 4

AJP-Renal (American Physiological Society)　若手研究者編集委員フェロー

2025年1月～継続中
American Heart Association　フェローシップ審査委員

2024年7月～継続中
Renal Failure誌 (Taylor & Francis)　編集委員

2024年1月～継続中
BMC Nephrology誌 (Springer Nature)　特集編集者

2025年7月～ 2026年3月

所属学協会 8

American Society of Nephrology

～継続中
American Heart Association

～継続中
American Physiological Society

～継続中
日本内科学会

～継続中
日本集中治療学会

～継続中
日本透析学会

～継続中
日本高血圧学会

～継続中
日本腎臓学会

～継続中

︎全件表示 ︎最初の5件までを表示

研究キーワード 5

血行動態
高血圧
代謝
生理学
腎臓

研究分野 1

ライフサイエンス / 腎臓内科学 /

受賞 18

Stephanie Watts Career Development Award Finalist

2025年9月　Hypertension Scientific Sessions 2025 (AHA)
Abstract of distinction, Renal section 2024

2024年4月　APS summit 2024
Water & Electrolyte Homeostasis Research Recognition Award

2024年4月　APS Summit 2024
HTN New Investigator Travel Awards

2023年9月　Hypertension Scientific Sessions 2023 (AHA)
MCW Office of Postdoctoral Education Spring 2023 Professional Development Award

2023年6月　MCW Office of Postdoctoral Education
Abstract of distinction, Renal section 2023

2023年4月　APS summit 2023
Renal Section Epithelial Transport Group Award

2023年4月　APS Summit 2023
Oral Abstract Award

2022年7月　2022 APS/ASN Control of Renal Function in Health and Disease Conference
New Investigator Award for Japanese Fellows

2021年9月　Hypertension Scientific Sessions 2021 (AHA)
Renal Section Research Recognition Award

2021年4月　Experimental Biology APS Renal Section
Honorable Mention, MCW Postdoctoral Fellow Paper of the Year Award competition

2021年　MCW Office of Postdoctoral Education
High impact paper in Hypertension for Fall of 2020

2020年10月　Hypertension, AHA　Renal Perfusion Pressure Determines Infiltration of Leukocytes in the Kidney of Rats With Angiotensin II-Induced Hypertension
New Investigator Travel Award

2020年9月　AHA Kidney Council
Postdoctoral Excellence in Renal Research Award

2020年4月　Experimental Biology APS Renal Section
Trainee Onsite Poster Award

2019年9月　Hypertension Scientific Sessions 2019 (AHA)
Hypertension Scientific Sessions 2019 (AHA)

2019年9月　AHA/ASH Joint Hypertension Sessions
Young Investigator Travel Grant

2018年2月　International Society of Nephrology
会長賞

2017年12月　腎不全研究会　腎うっ血による腎障害機序の解明

︎全件表示 ︎最初の5件までを表示

論文 19

Correcting fluorescein isothiocyanate-sinistrin half-life-derived glomerular filtration rate in rats during growth and salt-driven volume expansion. 国際誌査読有り

Satoshi Shimada, Ranjan K Dash, Allen W Cowley Jr

Kidney international　2026年7月24日

DOI： 10.1016/j.kint.2026.06.032 　

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INTRODUCTION: Transcutaneous fluorescein isothiocyanate (FITC)-sinistrin fluorescence enables convenient, minimally invasive estimation of the glomerular filtration rate (GFR) in rodents. However, the commonly used fixed-factor conversions (i.e., GFR/BW = conversion factor (21.33)/HL, where HL is sinistrin half-life and BW is body weight) assume the volume of distribution scales proportionally with BW. This assumption can bias GFR estimates when body composition shifts with growth or when extracellular fluid volume expands under high-salt intake. Here, we quantified these errors and developed improved HL-to-GFR conversion methods. METHODS: Male and female Dahl salt-sensitive rats with chronically implanted venous catheters underwent simultaneous measurements of serum and transcutaneous FITC-sinistrin fluorescence. Serum clearance provided reference GFR and serum-derived HL, and the transcutaneous signal provided transcutaneous HL. In separate cohorts, body composition and extracellular fluid were assessed by Nuclear Magnetic Resonance-Bioimpedance Spectroscopy. A regression of GFR×HL was performed using BW, age, sex, and salt intake. RESULTS: In low-salt fed rats, sex-specific BW-based models explained much of the variability in GFR×HL (females: 97.81×BW0.385; males: 203.0×BW0.855; BW in kg). Separately, using data from all rats across salt conditions, we derived a salt-dependent conversion to allow for temporal salt effects. The corrected model detected the transient increase in GFR on high-salt day 3 that was missed by a fixed factor. GFR scaled sub-linearly with BW (exponent 0.744). CONCLUSIONS: Allowing the sinistrin HL-to-GFR conversion to vary with BW and salt condition moderately improves the accuracy of HL-based FITC-sinistrin GFR estimates compared with a single fixed conversion factor and captures the transient GFR increase after salt loading. Sub-linear scaling of GFR supports allometric size adjustment (BW0.744) to reduce size-dependent bias and better reflect true GFR in growing rats.
NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys 査読有り

Satoshi Shimada, Chun Yang, Brian R. Hoffmann, Timothy J. Stodola, Theresa Kurth, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley, Jr

Hypertension　2026年3月

DOI： 10.1161/HYPERTENSIONAHA.125.25718 　
Sex Differences in Renal Mitochondrial Respiration and H2O2 Emission in Young Dahl Salt-Sensitive Rats 査読有り

Chun Yang, Devanshi D Dave, Sri Rahavi Boovarahan, Satoshi Shimada, Aron Geurts, Ranjan K Dash, Allen W Cowley, Jr

Function　2025年10月28日

DOI： 10.1093/function/zqaf045 　
Renal Medulla in Hypertension 招待有り査読有り

Allen W. Cowley, Richard J. Roman, David L. Mattson, Kleber G. Franchini, Paul M. O’Connor, Ayako Makino, Norman E. Taylor, Louise C. Evans, Takefumi Mori, Jeffrey G. Dickhout, Chunhua Jin, Noriyuki Miyata, Kazushige Nakanishi, Mátyás Szentiványi, Frank Park, Meredith M. Skelton, Theresa Kurth, Satoshi Shimada

2024年9月30日

DOI： 10.1161/hypertensionaha.124.21711 　

ISSN：0194-911X 1524-4563

詳細を見る詳細を閉じる

<jats:p>Studies have found that blood flow to the renal medulla is an important determinant of pressure-natriuresis and the long-term regulation of arterial pressure. First, a brief review of methods developed enabling the study of the medullary circulation is presented. Second, studies performed in rats are presented showing medullary blood flow plays a vital role in the pressure-natriuresis relationship and thereby in hypertension. Third, it is shown that chronic reduction of medullary blood flow results in hypertension and that enhancement of medullary blood flow reduces hypertension hereditary models of both salt-sensitive rats and salt-resistant forms of hypertension. The key role that medullary nitric oxide production plays in protecting this region from ischemic injury associated with circulating vasoconstrictor agents and reactive oxygen species is presented. The studies cited are largely the work of my students, research fellows, and colleagues with whom I have performed these studies dating from the late 1980s to more recent years.</jats:p>
Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity 査読有り

Chun Yang, Elena Isaeva, Satoshi Shimada, Theresa Kurth, Megan Stumpf, Nadezhda N. Zheleznova, Alexander Staruschenko, Ranjan K. Dash, Allen W. Cowley, Jr.

American Journal of Physiology-Renal Physiology　2024年9月1日

DOI： 10.1152/ajprenal.00403.2023 　
Metabolic responses of normal rat kidneys to a high salt intake 査読有り

Satoshi Shimada, Brian R. Hoffmann, Chun Yang, Theresa Kurth, Andrew S. Greene, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley, Jr

Function　2023年1月20日

DOI： 10.1101/2023.01.18.524636 　
Inhibition of platelet-derived growth factor pathway suppresses tubulointerstitial injury in renal congestion 査読有り

Takuma Matsuki, Takuo Hirose, Yusuke Ohsaki, Satoshi Shimada, Akari Endo, Hiroki Ito, Chika Takahashi, Seiko Yamakoshi, Ikuko Oba-Yabana, Go Anan, Toshiko Kato, Ryo Tajima, Shingo Nakayama, Tomoyoshi Kimura, Hannah Nakamura, Junichi Tani, Kazuhiro Takahashi, Shigeo Kure, Takefumi Mori

Journal of Hypertension　40　(10)　1935-1949　2022年8月19日
出版者・発行元： Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1097/hjh.0000000000003191 　

ISSN：0263-6352

eISSN：1473-5598

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Objective: Increased central venous pressure in congestive heart failure is responsible for renal dysfunction, which is mediated by renal venous congestion. Pericyte detachment from capillaries after renal congestion might trigger renal fibrogenesis via pericyte-myofibroblast transition (PMT). Platelet-derived growth factor receptors (PDGFRs), which are PMT indicators, were upregulated in our recently established renal congestion model. This study was designed to determine whether inhibition of the PDGFR pathway could suppress tubulointerstitial injury after renal congestion. Methods: The inferior vena cava between the renal veins was ligated in male Sprague-Dawley rats, inducing congestion only in the left kidney. Imatinib mesylate or vehicle were injected intraperitoneally daily from 1 day before the operation. Three days after the surgery, the effect of imatinib was assessed by physiological, morphological and molecular methods. The inhibition of PDGFRs against transforming growth factor-β1 (TGFB1)-induced fibrosis was also tested in human pericyte cell culture. Results: Increased kidney weight and renal fibrosis were observed in the congested kidneys. Upstream inferior vena cava (IVC) pressure immediately increased to around 20 mmHg after IVC ligation in both the imatinib and saline groups. Although vasa recta dilatation and pericyte detachment under renal congestion were maintained, imatinib ameliorated the increased kidney weight and suppressed renal fibrosis around the vasa recta. TGFB1-induced elevation of fibrosis markers in human pericytes was suppressed by PDGFR inhibitors at the transcriptional level. Conclusion: The activation of the PDGFR pathway after renal congestion was responsible for renal congestion-induced fibrosis. This mechanism could be a candidate therapeutic target for renoprotection against renal congestion-induced tubulointerstitial injury.
Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration 査読有り

Satoshi Shimada, Chun Yang, Vikash Kumar, David L. Mattson, Allen W. Cowley, Jr

Hypertension　2022年6月

DOI： 10.1161/HYPERTENSIONAHA.121.18643 　
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy 査読有り

Satoshi Shimada, Chun Yang, Theresa Kurth, Allen W. Cowley, Jr.

American Journal of Physiology-Renal Physiology　2022年5月1日

DOI： 10.1152/ajprenal.00376.2021 　
Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats 査読有り

Satoshi Shimada, Allen W. Cowley, Jr.

Journal of Visualized Experiments　(180)　2022年2月8日
出版者・発行元： MyJove Corporation
DOI： 10.3791/63560 　

eISSN：1940-087X
Renal Perfusion Pressure Determines Infiltration of Leukocytes in the Kidney of Rats With Angiotensin II-Induced Hypertension. 査読有り

Shimada S, Abais-Battad JM, Alsheikh AJ, Yang C, Stumpf M, Kurth T, Mattson DL, Cowley AW

Hypertension (Dallas, Tex. : 1979)　2020年8月

DOI： 10.1161/hypertensionaha.120.15295 　
The Early Effects of Uninephrectomy on Rat Kidney Metabolic State Using Optical Imaging. 査読有り

Mehrvar S, Foomani FH, Shimada S, Yang C, Zheleznova NN, Mostaghimi S, Cowley AW, Ranji M

Journal of biophotonics　2020年5月

DOI： 10.1002/jbio.202000089 　
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease 査読有り

Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung HO, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B. Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe

Nature Communications　10　(1)　2019年4月23日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41467-019-09735-4 　

eISSN：2041-1723

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Abstract Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are decreased in rats with limited proteinuria. In experimental models of diabetes, phenyl sulfate administration induces albuminuria and podocyte damage. In a diabetic patient cohort, phenyl sulfate levels significantly correlate with basal and predicted 2-year progression of albuminuria in patients with microalbuminuria. Inhibition of tyrosine phenol-lyase, a bacterial enzyme responsible for the synthesis of phenol from dietary tyrosine before it is metabolized into phenyl sulfate in the liver, reduces albuminuria in diabetic mice. Together, our results suggest that phenyl sulfate contributes to albuminuria and could be used as a disease marker and future therapeutic target in diabetic kidney disease.
Pathophysiological and molecular mechanisms involved in renal congestion in a novel rat model 査読有り

Satoshi Shimada, Takuo Hirose, Chika Takahashi, Emiko Sato, Satoshi Kinugasa, Yusuke Ohsaki, Kiyomi Kisu, Hiroshi Sato, Sadayoshi Ito, Takefumi Mori

Scientific Reports　8　(1)　2018年11月14日
出版者・発行元： Springer Nature America, Inc
DOI： 10.1038/s41598-018-35162-4 　
Concurrent isolated IgG2-positive membranous nephropathy and malignant B-cell lymphoma. 査読有り

Shimada S, Nakamichi T, Yamada G, Narumi K, Usubuchi H, Yamamoto T, Ichikawa S, Fukuhara N, Miyazaki M, Harigae H, Sato H, Ito S

CEN case reports　2018年5月

DOI： 10.1007/s13730-018-0336-z 　
Cardio-renal connection and SGLT2 inhibitors 招待有り

Satoshi Shimada

Cardioangiology　2017年10月

ISSN：1884-2909
Role of Chronic Use of Tolvaptan in Patients with Heart Failure Undergoing Peritoneal Dialysis 査読有り

Mori, T., Kurasawa, N., Ohsaki, Y., Koizumi, K., Sato, S., Oba-Yabana, I., Shimada, S., Sato, E., Naganuma, E., Tsuchikawa, M., Ito, S.

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis　32　2016年
Efficacy and Biocompatibility of Neutral Icodextrin Peritoneal Dialysis Fluid 査読有り

Shimada, S., Mori, T., Koizumi, K., Sato, S., Oba-Yabana, I., Ohsaki, Y., Sato, E., Naganuma, E., Kurasawa, N., Tsuchikawa, M., Ito, S.

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis　32　2016年
Myocardial depression induced by severe sepsis: Successful rescue using extracorporeal cardiopulmonary resuscitation from initial phase of severe sepsis 査読有り

Tomioka, T., Shimada, S., Ito, Y., Inoue, K.

BMJ Case Reports　2015　2015年

DOI： 10.1136/bcr-2015-210185

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MISC 9

「心腎連関と内分泌代謝」心腎連関とSGLT2阻害薬

島田佐登志, 大崎雄介, 廣瀬卓男, 森建文, 伊藤貞嘉

日本内分泌学会雑誌　94　(4)　1520-1520　2018年12月
出版者・発行元： (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
ラット腎うっ血モデルを用いた腎障害機序の解明

島田佐登志, 廣瀬卓男, 高橋知香, 衣笠哲史, 大崎雄介, 本田和也, 矢花郁子, 室谷嘉一, 伊藤貞嘉, 森建文

日本内分泌学会雑誌　94　(4)　1564-1564　2018年12月
出版者・発行元： (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
腎うっ血による腎障害機序の解明

島田佐登志, 大崎雄介, 高橋知香, 廣瀬卓男, 佐藤恵美子, 伊藤貞嘉, 森建文

日本腎臓学会誌　60　(3)　334-334　2018年4月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
低真空走査電子顕微鏡によるラット腎臓光学顕微鏡用組織標本の検討

廣瀬卓男, 衣笠哲史, 島田佐登志, 高橋知香, 矢花郁子, 大崎雄介, 室谷嘉一, 伊藤貞嘉, 森建文

日本腎臓学会誌　60　(3)　363-363　2018年4月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
腎うっ血による腎障害機序の解明

島田佐登志, 大崎雄介, 高橋知香, 廣瀬卓男, 佐藤恵美子, 伊藤貞嘉, 森建文

日本腎臓学会誌　60　(3)　334-334　2018年4月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385
低真空走査電子顕微鏡によるラット腎臓光学顕微鏡用組織標本の検討

廣瀬卓男, 衣笠哲史, 島田佐登志, 高橋知香, 矢花郁子, 大崎雄介, 室谷嘉一, 伊藤貞嘉, 森建文

日本腎臓学会誌　60　(3)　363-363　2018年4月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385
意義不明の単クローン性ガンマグロブリン血症(MGUS)を伴う膜性増殖性糸球体腎炎の一例

熊倉慧, 中道崇, 島田佐登志, 秋保真穂, 山田元, 宮崎真理子, 佐藤博, 伊藤貞嘉

日本腎臓学会誌　59　(6)　917-917　2017年9月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
B細胞性リンパ腫合併膜性腎症に対してリツキシマブを投与した1例

島田佐登志, 中道崇, 山田元, 鳴海かほり, 市川聡, 福原規子, 山本多恵, 宮崎真理子, 張替秀郎, 佐藤博, 伊藤貞嘉

日本腎臓学会誌　58　(6)　776-776　2016年8月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385
ラット腹膜中皮細胞におけるブドウ糖刺激によるミトコンドリア由来活性酸素種産生メカニズムの解明

島田佐登志, 森建文, 大崎雄介, 矢花郁子, 伊藤貞嘉

日本腎臓学会誌　58　(3)　258-258　2016年5月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728

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講演・口頭発表等 42

Spatial Analysis of Metabolic Reprogramming and Its Redox Regulation in Salt-Sensitive Hypertension

Satoshi Shimada

Hypertension Scientific Sessions 2025 (AHA)
Oxidative Stress Impairs Fatty Acid Oxidation and Induces Proteolysis in Dahl Salt-Sensitive Rats

Satoshi Shimada, Chun Yang, Brian R. Hoffman, Tim Stodola, Theresa Kurth, Andrew S. Greene, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley

Hypertension Scientific Sessions 2025 (AHA)
Impact of Extracellular Volume on Transcutaneous GFR Measurement Accuracy in Male and Female rats

Satoshi Shimada, Ranjan Dash, Allen Cowley Jr

American Physiology Summit 2025
Oxidative stress induced suppression of metabolism pathways in Dahl Salt-Sensitive rat

Shimada, Satoshi, Yang, Chun, Dash, Ranjan K., Cowley Jr Allen W.

ASN Kidney Week 2024
Oxidative stress induced suppression of metabolism pathways in Dahl Salt-Sensitive rat

Satoshi Shimada, Chun Yang, Ranjan K. Dash, Allen W. Cowley, J.

Complex Trait Community--Rat Genomics 2024
GFR, renal blood flow, and kidney metabolic responses to high salt intake in rats.

Satoshi Shimada

MCW Physiology Seminar Series　2024年9月18日
Renal hemodynamic and transcriptomic changes in response to salt in Dahl salt-sensitive rats

Satoshi Shimada, Chun Yang, Ranjan K. Dash, Allen W. Cowley, J.

Hypertension Scientific Sessions 2024 (AHA)
High Salt Induced Alterations in Substrate Metabolism, Respiratory Activity, and Acidification in Isolated Proximal Tubules from Dahl Salt-Sensitive Rats

Ranjan Dash, Chun Yang, Devanshi Dave, Theresa Kurth, Satoshi Shimada, Allen Cowley Jr

American Physiology Summit 2024
NADPH Oxidase 4 Knockout in Dahl Salt-Sensitive Rats Impacts Kidney O2 Consumption and UCP2 Responses to a High Salt Diet

Satoshi Shimada, Chun Yang, Ranjan Dash, Allen Cowley Jr

American Physiology Summit 2024
Dynamic shift towards increased O2 consumption and reduced lactate uptake during acute volume expansion in Sprague Dawley (SD) rats

Satoshi Shimada, Chun Yang, Ranjan Dash, Allen Cowley Jr

American Physiology Summit 2024
High Salt Induced Mitochondrial Uncoupling And Enhanced Respiratory Activity In Isolated Proximal Tubules From Dahl Salt-sensitive Rats

Chun Yang, Ranjan K Dash, Terry Kurth, Satoshi Shimada, Allen W Cowley Jr

Hypertension Scientific Sessions 2023 (AHA)
Evidence Of Increased Glycolysis In Renal Cortex Of High Salt Fed Sprague Dawley Rats

Satoshi Shimada, Brian Hoffmann, Chun Yang, Theresa Kurth, Andrew Greene, Mingyu Liang, Ranjan K Dash, Allen W Cowley

Hypertension Scientific Sessions 2023 (AHA)
Impact Of NADPH Oxidase 4 Knockout On Renal O2 Consumption In Dahl Salt-sensitive Rats

Satoshi Shimada, Ranjan K Dash, Allen W Cowley

Hypertension Scientific Sessions 2023 (AHA)
Alterations of Mitochondrial Respiratory Function in Isolated Nephron Segments of Dahl Salt-Sensitive Rats in Salt-Induced Hypertension

Ranjan Dash, Chun Yang, Satoshi Shimada, Nadya Zheleznova, Allen Cowley Jr

American Physiology Summit 2023
The effects of excess salt intake on the kidney metabolism in normal Sprague Dawley rats

Satoshi Shimada, Brian Hoffmann, Chun Yang, Theresa Kurth, Andrew Greene, Mingyu Liang, Ranjan Dash, Allen Cowley Jr
Compensatory Changes in Oxygen Extraction and Metabolomic Profiles in the Kidney of Sprague-Dawley Rats fed a High-Salt Diet

Satoshi Shimada

MCW Physiology Seminar Series　2023年1月13日
Tubular Sites Of Mtorc2 Inhibition Of Sodium Transport In Dahl Salt-sensitive Rats.

Allen W Cowley, Chun Yang, Olena Isaeva, Satoshi Shimada, Terry Kurth, Megan Stumpf, Alison J Kriegel, Ranjan K Dash

Hypertension Scientific Sessions 2022 (AHA)
Compensatory Changes in Metabolomic Profiles In The Kidney Of Sprague-Dawley Rats Fed A High-salt Diet

Satoshi Shimada, Brian R Hoffmann, Andrew S Greene, Mingyu Liang, Ranjan K Dash, Allen W Cowley

Hypertension Scientific Sessions 2022 (AHA)
Compensatory Changes in Oxygen Extraction and Metabolomic Profiles in the Kidney of Sprague-Dawley Rats fed a High-Salt Diet

Satoshi Shimada, Brian R. Hoffmann, Chun Yang, Theresa Kurth, Andrew S. Greene, Mingyu Liang, Dash K. Ranjan, Allen W. Cowley J.

Control of Renal Function in Health and Disease Conference 2022 (APS/ASN)
Metabolomic Kidney Input and Output Analyses in Salt‐Sensitive Hypertension

Brian R Hoffmann, Satoshi Shimada, Andrew S Greene, Mingyu Liang, Ranjan Dash, Allen Cowley Jr

2022 Exprimental Biology Conference
Compensatory Changes in Oxygen Extraction and Metabolomic Profiles in the Kidney of Sprague-Dawley Rats fed a High-Salt Diet

Satoshi Shimada, Brian Hoffmann, Andrew Greene, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley, J.

2022 Exprimental Biology Conference
Changes In Renal Oxygen Consumption with High-salt Diet Differ Between Sprague Dawley And Dahl Salt Sensitive Rats

Satoshi Shimada, Ranjan K Dash, Allen W Cowley

Hypertension Scientific Sessions 2021 (AHA)
Acute Increases Of Renal Perfusion Pressure Activate Mechanistic Target Of Rapamycin Complex 1 And Increase Macrophage Infiltration In The Kidney Of Sprague Dawley Rats

Satoshi Shimada, Chun Yang, Vikash Kumar, David L Mattson, Allen W Cowley

Hypertension Scientific Sessions 2021 (AHA)
Acute Elevation of Renal Perfusion Pressure Activates Mechanistic Target of Rapamycin Complex 1 (mTORC1) in Rats

Satoshi Shimada, Vikash Kumar, Chun Yang, David L. Mattson, Allen W. Cowley, J.

2021 Exprimental Biology Conference
High Salt Diet Increases Renal Oxygen Consumption in Sprague-Dawley Rats

Satoshi Shimada, Ranjan K. Dash, Allen W. Cowley Jr

2021 Exprimental Biology Conference
Role Of Angiotensin in Determining Blood Flow Remaining Kidney Following Nephrectomy

Satoshi Shimada, Allen W. Cowley, J.

Hypertension Scientific Sessions 2020 (AHA)
Kidney mitochondrial redox state 3 days following uninephrectomy in rats determined by cyro-fluorescence optical imaging

Allen W. Cowley Jr, Chun Yang, Satoshi Shimada, Nadya Zheleznova, Shima Mehrvar, Farnaz Foomani, Soudeh Mostaghimi, Mahsa Ranji

2020 Exprimental Biology Conference
Angiotensin II activates mTORC1 pathway in the kidneys through a pressor-independent mechanism

Satoshi Shimada, Chun Yang, Vikash Kumar, Megan Stumpf, Theresa Kurth, David L. Mattson, Allen W. Cowley J.

2020 Exprimental Biology Conference
Elevated angiotensin II leads to renal capillary rarefaction and leukocyte infiltration which is dependent upon elevated renal perfusion pressure

Satoshi Shimada, Justine M., Abais-Battad, Ammar J. Alsheikh, Chun Yang, Megan Stumpf, Theresa Kurth, David L. Mattson, Allen W. Cowley J.

2020 Angiotensin GRC
Defining Molecular Pathways Involved in the Early Compensatory Response of Healthy Kidneys to Contralateral Uninephrectomy

Allen W. Cowley Jr, Satoshi Shimada, Chun Yang, Nadezhda Zheleznova, Theresa Kurth, Mahsa Ranji, Shima Mehrvar, Angela Mathison, Thiago Milech De Assuncao, Raul Urrutia

2019 Control of Renal Function in Health and Disease Conference
Renin-angiotensin responses initiate the early renal hemodynamic responses of healthy kidneys to uninephrectomy.

Satoshi Shimada, Chun Yang, Theresa Kurth, Allen W. Cowley, J.

2019 Control of Renal Function in Health and Disease Conference
EXPRESSION OF (PRO)RENIN RECEPTOR IN RAT RENAL CONGESTION MODEL

T. Hirose, S. Shimada, T. Matsuki, C. Takahashi, H. Nakamura, S. Kinugasa, Y. Muroya, J. Tani, S. Ito, T. Mori

ISN WCN 2019
IMATINIB ATTENUATES PERYCITE-MYOFIBROBLAST TRANSITION IN RENAL CONGESTION IN RATS

T. MATSUKI, T. Hirose, S. Shimada, C. Takahashi, S. Kinugasa, Y. Muroya, H. Nakamura, J. Tani, S. Itoh, T. Mori

ISN WCN 2019
Reduction of circulating renin-angiotensin following uninephrectomy signals kidney hypertrophy via increase in renal blood flow

Satoshi Shimada, Allen W. Cowley Jr

2019 Exprimental Biology Conference
Pericyte Detachment is Involved in Renal Congestion in a Novel Rat Model

Satoshi Shimada, Takuo Hirose, Chika Takahashi, Emiko Sato, Satoshi Kinugasa, Sadayoshi Ito, Takefumi Mori

Hypertension Scientific Sessions 2018 (AHA)
Pathophysiological analysis of renal congestion using a novel rat model

Shimada S., Ohsaki Y., Takahashi C., Hirose T., Sato E., Ito S., Mori T.

ISN frontiers meeting 2018
Pathophysiological analysis of renal congestion using a novel rat model

Shimada Satoshi, Mori Takefumi, Ohsaki Yusuke, Takahashi Chika, Ito Sadayoshi

ASN Kidney Week 2017
Glucose induces mitochondrial reactive oxygen species through carbonyl stress and respiratory chain in rat peritoneal mesothelial cells

Satoshi Shimada, Yusuke Ohsaki, Chika Takahashi, Takefumi Mori, Sadayoshi Ito

ASN Kidney Week 2015
ラット腹膜中皮細胞におけるブドウ糖刺激によるミトコンドリア由来活性酸素種産生メカニズムの解明

島田佐登志, 森建文, 大崎雄介, 矢花郁子, 伊藤貞嘉

第59回日本腎臓学会学術総会
Water and the Solute Removal in the Neutralizated Icodextrin Peritoneal Dialysis Fluid

Satoshi Shimada, Takefumi Mori, Kenji Koizumi, Shinichi Sato, Ikuko Oba-Yabana, Yusuke Ohsaki, Emiko Sato, Eri Naganuma, Naho Kurasawa, Mihoko Tsuchikawa, Sadayoshi Ito

36th Annual Dialysis Conference
ブドウ糖およびGDPsはラット腹膜中皮細胞でミトコンドリア由来の活性酸素（ROS）を生じる

島田佐登志, 森建文, 大崎雄介, 伊藤貞嘉

第21回日本腹膜透析医学会学術集会・総会
心症状を主体とした間質性肺炎合併の抗ARS抗体症候群の1例

島田佐登志, 城田祐子, 武藤智之, 秋田佳奈恵, 藤田洋子, 藤井博司, 石井智徳, 張替秀郎

第25回日本リウマチ学会北海道・東北支部学術集会

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 3

Effects of salt loading upon renal energy production, oxidative stress and injury

提供機関：American Heart Association

制度名：Career Development Award

研究機関：Medical College of Wisconsin

2024年7月～ 2027年6月
Impact of High Salt Diet on Kidney Oxygen and Substrate Metabolism

提供機関：American Heart Association

制度名：Postdoctoral Fellowship

研究機関：Medical College of Wisconsin

2023年1月～ 2025年12月
心不全の腎うっ血における腎障害機序の解明

森建文, 佐藤恵美子, 伊藤貞嘉, 大崎雄介, 矢花郁子, 島田佐登志, 高橋知香

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku Medical and Pharmaceutical University

2016年4月1日～ 2019年3月31日

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腎うっ血に伴う腎内分子メカニズムと治療戦略を解明するため、下大静脈の両腎静脈間を閉塞する新しい腎うっ血モデルを開発した。このモデルは同じ個体でありながら左腎のうっ血腎とうっ血のない右腎を比較でき、個体差がない腎うっ血特異的な分子メカニズムを評価できる。本モデルと細胞培養系を用いて、腎うっ血に伴う腎臓障害に酸性オルガネラにおけるタンパク質輸送の障害や直血管の障害が関与していることを明らかにした。