Details of the Researcher

PHOTO

Satoshi Shimada
Section
Tohoku University Hospital
Job title
Assistant Professor
e-Rad No.
11030627

Research History 6

  • 2026/06 - Present
    Tohoku University　University Hospital Nephrology　Assistant Professor

  • 2024/07 - 2026/05
    Medical College of Wisconsin　Physiology　Instructor

  • 2018/06 - 2026/05
    Tohoku University　University Hospital Nephrology, Endocrinology and Vascular Medicine　Adjunct Faculty

  • 2018/06 - 2024/06
    Medical College of Wisconsin　Physiology　Postdoctoral Research Fellow

  • 2015/04 - 2018/05
    Tohoku University　University Hospital Nephrology, Endocrinology and Vascular Medicine　Adjunct Physician

  • 2013/04 - 2015/03
    South Miyagi Medical Center　Resident

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Education 2

  • Tohoku University　Graduate School of Medicine

    2015/04 - 2019/03

  • Tohoku University　Faculty of Medicine　School of Medicine

    2007/04 - 2013/03

Committee Memberships 4

  • AJP-Renal (American Physiological Society)　Early Career Editorial Fellowship Program

    2025/01 - Present

  • American Heart Association　Grant Reviewer, Fellowship Review Committee

    2024/07 - Present

  • Renal Failure, Taylor & Francis　Editorial Board Member

    2024/01 - Present

  • BMC Nephrology (Springer Nature)　Guest Editor

    2025/07 - 2026/03

Professional Memberships 8

  • American Society of Nephrology

    - Present

  • American Heart Association

    - Present

  • American Physiological Society

    - Present

  • Japanese Society of Internal Medicine

    - Present

  • Japanese Society of Intensive Care Medicine

    - Present

  • Japanese Society for Dialysis Therapy

    - Present

  • Japanese Society of Hypertension

    - Present

  • Japanese Society of Nephrology

    - Present

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Research Interests 5

  • hemodynamics

  • hypertension

  • metabolism

  • Physiology

  • kidney

Research Areas 1

  • Life sciences / Nephrology /

Awards 18

  1. Stephanie Watts Career Development Award Finalist

    2025/09　Hypertension Scientific Sessions 2025 (AHA)

  2. Abstract of distinction, Renal section 2024

    2024/04　APS summit 2024

  3. Water & Electrolyte Homeostasis Research Recognition Award

    2024/04　APS Summit 2024

  4. HTN New Investigator Travel Awards

    2023/09　Hypertension Scientific Sessions 2023 (AHA)

  5. MCW Office of Postdoctoral Education Spring 2023 Professional Development Award

    2023/06　MCW Office of Postdoctoral Education

  6. Abstract of distinction, Renal section 2023

    2023/04　APS summit 2023

  7. Renal Section Epithelial Transport Group Award

    2023/04　APS Summit 2023

  8. Oral Abstract Award

    2022/07　2022 APS/ASN Control of Renal Function in Health and Disease Conference

  9. New Investigator Award for Japanese Fellows

    2021/09　Hypertension Scientific Sessions 2021 (AHA)

  10. Renal Section Research Recognition Award

    2021/04　Experimental Biology APS Renal Section

  11. Honorable Mention, MCW Postdoctoral Fellow Paper of the Year Award competition

    2021　MCW Office of Postdoctoral Education

  12. High impact paper in Hypertension for Fall of 2020

    2020/10　Hypertension, AHA　Renal Perfusion Pressure Determines Infiltration of Leukocytes in the Kidney of Rats With Angiotensin II-Induced Hypertension

  13. New Investigator Travel Award

    2020/09　AHA Kidney Council

  14. Postdoctoral Excellence in Renal Research Award

    2020/04　Experimental Biology APS Renal Section

  15. Trainee Onsite Poster Award

    2019/09　Hypertension Scientific Sessions 2019 (AHA)

  16. Hypertension Scientific Sessions 2019 (AHA)

    2019/09　AHA/ASH Joint Hypertension Sessions

  17. Young Investigator Travel Grant

    2018/02　International Society of Nephrology

  18. The Chairman`s Award

    2017/12　Japanese Society of Pathophysiology in Kidney Failure

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Papers 19

  1. Correcting fluorescein isothiocyanate-sinistrin half-life-derived glomerular filtration rate in rats during growth and salt-driven volume expansion. International-journal Peer-reviewed

    Satoshi Shimada, Ranjan K Dash, Allen W Cowley Jr

    Kidney international　2026/07/24

    DOI： 10.1016/j.kint.2026.06.032 　

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    INTRODUCTION: Transcutaneous fluorescein isothiocyanate (FITC)-sinistrin fluorescence enables convenient, minimally invasive estimation of the glomerular filtration rate (GFR) in rodents. However, the commonly used fixed-factor conversions (i.e., GFR/BW = conversion factor (21.33)/HL, where HL is sinistrin half-life and BW is body weight) assume the volume of distribution scales proportionally with BW. This assumption can bias GFR estimates when body composition shifts with growth or when extracellular fluid volume expands under high-salt intake. Here, we quantified these errors and developed improved HL-to-GFR conversion methods. METHODS: Male and female Dahl salt-sensitive rats with chronically implanted venous catheters underwent simultaneous measurements of serum and transcutaneous FITC-sinistrin fluorescence. Serum clearance provided reference GFR and serum-derived HL, and the transcutaneous signal provided transcutaneous HL. In separate cohorts, body composition and extracellular fluid were assessed by Nuclear Magnetic Resonance-Bioimpedance Spectroscopy. A regression of GFR×HL was performed using BW, age, sex, and salt intake. RESULTS: In low-salt fed rats, sex-specific BW-based models explained much of the variability in GFR×HL (females: 97.81×BW0.385; males: 203.0×BW0.855; BW in kg). Separately, using data from all rats across salt conditions, we derived a salt-dependent conversion to allow for temporal salt effects. The corrected model detected the transient increase in GFR on high-salt day 3 that was missed by a fixed factor. GFR scaled sub-linearly with BW (exponent 0.744). CONCLUSIONS: Allowing the sinistrin HL-to-GFR conversion to vary with BW and salt condition moderately improves the accuracy of HL-based FITC-sinistrin GFR estimates compared with a single fixed conversion factor and captures the transient GFR increase after salt loading. Sub-linear scaling of GFR supports allometric size adjustment (BW0.744) to reduce size-dependent bias and better reflect true GFR in growing rats.

  2. NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys Peer-reviewed

    Satoshi Shimada, Chun Yang, Brian R. Hoffmann, Timothy J. Stodola, Theresa Kurth, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley, Jr

    Hypertension　2026/03

    DOI： 10.1161/HYPERTENSIONAHA.125.25718 　

  3. Sex Differences in Renal Mitochondrial Respiration and H2O2 Emission in Young Dahl Salt-Sensitive Rats Peer-reviewed

    Chun Yang, Devanshi D Dave, Sri Rahavi Boovarahan, Satoshi Shimada, Aron Geurts, Ranjan K Dash, Allen W Cowley, Jr

    Function　2025/10/28

    DOI： 10.1093/function/zqaf045 　

  4. Renal Medulla in Hypertension Invited Peer-reviewed

    Allen W. Cowley, Richard J. Roman, David L. Mattson, Kleber G. Franchini, Paul M. O’Connor, Ayako Makino, Norman E. Taylor, Louise C. Evans, Takefumi Mori, Jeffrey G. Dickhout, Chunhua Jin, Noriyuki Miyata, Kazushige Nakanishi, Mátyás Szentiványi, Frank Park, Meredith M. Skelton, Theresa Kurth, Satoshi Shimada

    2024/09/30

    DOI： 10.1161/hypertensionaha.124.21711 　

    ISSN： 0194-911X 1524-4563

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    <jats:p>Studies have found that blood flow to the renal medulla is an important determinant of pressure-natriuresis and the long-term regulation of arterial pressure. First, a brief review of methods developed enabling the study of the medullary circulation is presented. Second, studies performed in rats are presented showing medullary blood flow plays a vital role in the pressure-natriuresis relationship and thereby in hypertension. Third, it is shown that chronic reduction of medullary blood flow results in hypertension and that enhancement of medullary blood flow reduces hypertension hereditary models of both salt-sensitive rats and salt-resistant forms of hypertension. The key role that medullary nitric oxide production plays in protecting this region from ischemic injury associated with circulating vasoconstrictor agents and reactive oxygen species is presented. The studies cited are largely the work of my students, research fellows, and colleagues with whom I have performed these studies dating from the late 1980s to more recent years.</jats:p>

  5. Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity Peer-reviewed

    Chun Yang, Elena Isaeva, Satoshi Shimada, Theresa Kurth, Megan Stumpf, Nadezhda N. Zheleznova, Alexander Staruschenko, Ranjan K. Dash, Allen W. Cowley, Jr.

    American Journal of Physiology-Renal Physiology　2024/09/01

    DOI： 10.1152/ajprenal.00403.2023 　

  6. Metabolic responses of normal rat kidneys to a high salt intake Peer-reviewed

    Satoshi Shimada, Brian R. Hoffmann, Chun Yang, Theresa Kurth, Andrew S. Greene, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley, Jr

    Function　2023/01/20

    DOI： 10.1101/2023.01.18.524636 　

  7. Inhibition of platelet-derived growth factor pathway suppresses tubulointerstitial injury in renal congestion Peer-reviewed

    Takuma Matsuki, Takuo Hirose, Yusuke Ohsaki, Satoshi Shimada, Akari Endo, Hiroki Ito, Chika Takahashi, Seiko Yamakoshi, Ikuko Oba-Yabana, Go Anan, Toshiko Kato, Ryo Tajima, Shingo Nakayama, Tomoyoshi Kimura, Hannah Nakamura, Junichi Tani, Kazuhiro Takahashi, Shigeo Kure, Takefumi Mori

    Journal of Hypertension　40　(10)　1935-1949　2022/08/19

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1097/hjh.0000000000003191 　

    ISSN： 0263-6352

    eISSN： 1473-5598

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    Objective: Increased central venous pressure in congestive heart failure is responsible for renal dysfunction, which is mediated by renal venous congestion. Pericyte detachment from capillaries after renal congestion might trigger renal fibrogenesis via pericyte-myofibroblast transition (PMT). Platelet-derived growth factor receptors (PDGFRs), which are PMT indicators, were upregulated in our recently established renal congestion model. This study was designed to determine whether inhibition of the PDGFR pathway could suppress tubulointerstitial injury after renal congestion. Methods: The inferior vena cava between the renal veins was ligated in male Sprague-Dawley rats, inducing congestion only in the left kidney. Imatinib mesylate or vehicle were injected intraperitoneally daily from 1 day before the operation. Three days after the surgery, the effect of imatinib was assessed by physiological, morphological and molecular methods. The inhibition of PDGFRs against transforming growth factor-β1 (TGFB1)-induced fibrosis was also tested in human pericyte cell culture. Results: Increased kidney weight and renal fibrosis were observed in the congested kidneys. Upstream inferior vena cava (IVC) pressure immediately increased to around 20 mmHg after IVC ligation in both the imatinib and saline groups. Although vasa recta dilatation and pericyte detachment under renal congestion were maintained, imatinib ameliorated the increased kidney weight and suppressed renal fibrosis around the vasa recta. TGFB1-induced elevation of fibrosis markers in human pericytes was suppressed by PDGFR inhibitors at the transcriptional level. Conclusion: The activation of the PDGFR pathway after renal congestion was responsible for renal congestion-induced fibrosis. This mechanism could be a candidate therapeutic target for renoprotection against renal congestion-induced tubulointerstitial injury.

  8. Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration Peer-reviewed

    Satoshi Shimada, Chun Yang, Vikash Kumar, David L. Mattson, Allen W. Cowley, Jr

    Hypertension　2022/06

    DOI： 10.1161/HYPERTENSIONAHA.121.18643 　

  9. Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy Peer-reviewed

    Satoshi Shimada, Chun Yang, Theresa Kurth, Allen W. Cowley, Jr.

    American Journal of Physiology-Renal Physiology　2022/05/01

    DOI： 10.1152/ajprenal.00376.2021 　

  10. Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats Peer-reviewed

    Satoshi Shimada, Allen W. Cowley, Jr.

    Journal of Visualized Experiments　(180)　2022/02/08

    Publisher: MyJove Corporation

    DOI： 10.3791/63560 　

    eISSN： 1940-087X

  11. Renal Perfusion Pressure Determines Infiltration of Leukocytes in the Kidney of Rats With Angiotensin II-Induced Hypertension. Peer-reviewed

    Shimada S, Abais-Battad JM, Alsheikh AJ, Yang C, Stumpf M, Kurth T, Mattson DL, Cowley AW

    Hypertension (Dallas, Tex. : 1979)　2020/08

    DOI： 10.1161/hypertensionaha.120.15295 　

  12. The Early Effects of Uninephrectomy on Rat Kidney Metabolic State Using Optical Imaging. Peer-reviewed

    Mehrvar S, Foomani FH, Shimada S, Yang C, Zheleznova NN, Mostaghimi S, Cowley AW, Ranji M

    Journal of biophotonics　2020/05

    DOI： 10.1002/jbio.202000089 　

  13. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease Peer-reviewed

    Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung HO, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B. Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe

    Nature Communications　10　(1)　2019/04/23

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41467-019-09735-4 　

    eISSN： 2041-1723

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    Abstract Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are decreased in rats with limited proteinuria. In experimental models of diabetes, phenyl sulfate administration induces albuminuria and podocyte damage. In a diabetic patient cohort, phenyl sulfate levels significantly correlate with basal and predicted 2-year progression of albuminuria in patients with microalbuminuria. Inhibition of tyrosine phenol-lyase, a bacterial enzyme responsible for the synthesis of phenol from dietary tyrosine before it is metabolized into phenyl sulfate in the liver, reduces albuminuria in diabetic mice. Together, our results suggest that phenyl sulfate contributes to albuminuria and could be used as a disease marker and future therapeutic target in diabetic kidney disease.

  14. Pathophysiological and molecular mechanisms involved in renal congestion in a novel rat model Peer-reviewed

    Satoshi Shimada, Takuo Hirose, Chika Takahashi, Emiko Sato, Satoshi Kinugasa, Yusuke Ohsaki, Kiyomi Kisu, Hiroshi Sato, Sadayoshi Ito, Takefumi Mori

    Scientific Reports　8　(1)　2018/11/14

    Publisher: Springer Nature America, Inc

    DOI： 10.1038/s41598-018-35162-4 　

  15. Concurrent isolated IgG2-positive membranous nephropathy and malignant B-cell lymphoma. Peer-reviewed

    Shimada S, Nakamichi T, Yamada G, Narumi K, Usubuchi H, Yamamoto T, Ichikawa S, Fukuhara N, Miyazaki M, Harigae H, Sato H, Ito S

    CEN case reports　2018/05

    DOI： 10.1007/s13730-018-0336-z 　

  16. Cardio-renal connection and SGLT2 inhibitors Invited

    Satoshi Shimada

    Cardioangiology　2017/10

    ISSN： 1884-2909

  17. Role of Chronic Use of Tolvaptan in Patients with Heart Failure Undergoing Peritoneal Dialysis Peer-reviewed

    Mori, T., Kurasawa, N., Ohsaki, Y., Koizumi, K., Sato, S., Oba-Yabana, I., Shimada, S., Sato, E., Naganuma, E., Tsuchikawa, M., Ito, S.

    Advances in peritoneal dialysis. Conference on Peritoneal Dialysis　32　2016

  18. Efficacy and Biocompatibility of Neutral Icodextrin Peritoneal Dialysis Fluid Peer-reviewed

    Shimada, S., Mori, T., Koizumi, K., Sato, S., Oba-Yabana, I., Ohsaki, Y., Sato, E., Naganuma, E., Kurasawa, N., Tsuchikawa, M., Ito, S.

    Advances in peritoneal dialysis. Conference on Peritoneal Dialysis　32　2016

  19. Myocardial depression induced by severe sepsis: Successful rescue using extracorporeal cardiopulmonary resuscitation from initial phase of severe sepsis Peer-reviewed

    Tomioka, T., Shimada, S., Ito, Y., Inoue, K.

    BMJ Case Reports　2015　2015

    DOI： 10.1136/bcr-2015-210185 　

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Misc. 9

  1. 「心腎連関と内分泌代謝」 心腎連関とSGLT2阻害薬

    島田 佐登志, 大崎 雄介, 廣瀬 卓男, 森 建文, 伊藤 貞嘉

    日本内分泌学会雑誌　94　(4)　1520-1520　2018/12

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  2. ラット腎うっ血モデルを用いた腎障害機序の解明

    島田 佐登志, 廣瀬 卓男, 高橋 知香, 衣笠 哲史, 大崎 雄介, 本田 和也, 矢花 郁子, 室谷 嘉一, 伊藤 貞嘉, 森 建文

    日本内分泌学会雑誌　94　(4)　1564-1564　2018/12

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  3. 腎うっ血による腎障害機序の解明

    島田 佐登志, 大崎 雄介, 高橋 知香, 廣瀬 卓男, 佐藤 恵美子, 伊藤 貞嘉, 森 建文

    日本腎臓学会誌　60　(3)　334-334　2018/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  4. 低真空走査電子顕微鏡によるラット腎臓光学顕微鏡用組織標本の検討

    廣瀬 卓男, 衣笠 哲史, 島田 佐登志, 高橋 知香, 矢花 郁子, 大崎 雄介, 室谷 嘉一, 伊藤 貞嘉, 森 建文

    日本腎臓学会誌　60　(3)　363-363　2018/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  5. 腎うっ血による腎障害機序の解明

    島田 佐登志, 大崎 雄介, 高橋 知香, 廣瀬 卓男, 佐藤 恵美子, 伊藤 貞嘉, 森 建文

    日本腎臓学会誌　60　(3)　334-334　2018/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  6. 低真空走査電子顕微鏡によるラット腎臓光学顕微鏡用組織標本の検討

    廣瀬 卓男, 衣笠 哲史, 島田 佐登志, 高橋 知香, 矢花 郁子, 大崎 雄介, 室谷 嘉一, 伊藤 貞嘉, 森 建文

    日本腎臓学会誌　60　(3)　363-363　2018/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  7. 意義不明の単クローン性ガンマグロブリン血症(MGUS)を伴う膜性増殖性糸球体腎炎の一例

    熊倉 慧, 中道 崇, 島田 佐登志, 秋保 真穂, 山田 元, 宮崎 真理子, 佐藤 博, 伊藤 貞嘉

    日本腎臓学会誌　59　(6)　917-917　2017/09

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  8. B細胞性リンパ腫合併膜性腎症に対してリツキシマブを投与した1例

    島田 佐登志, 中道 崇, 山田 元, 鳴海 かほり, 市川 聡, 福原 規子, 山本 多恵, 宮崎 真理子, 張替 秀郎, 佐藤 博, 伊藤 貞嘉

    日本腎臓学会誌　58　(6)　776-776　2016/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  9. ラット腹膜中皮細胞におけるブドウ糖刺激によるミトコンドリア由来活性酸素種産生メカニズムの解明

    島田 佐登志, 森 建文, 大崎 雄介, 矢花 郁子, 伊藤 貞嘉

    日本腎臓学会誌　58　(3)　258-258　2016/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

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Presentations 42

  1. Spatial Analysis of Metabolic Reprogramming and Its Redox Regulation in Salt-Sensitive Hypertension

    Satoshi Shimada

    Hypertension Scientific Sessions 2025 (AHA)

  2. Oxidative Stress Impairs Fatty Acid Oxidation and Induces Proteolysis in Dahl Salt-Sensitive Rats

    Satoshi Shimada, Chun Yang, Brian R. Hoffman, Tim Stodola, Theresa Kurth, Andrew S. Greene, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley

    Hypertension Scientific Sessions 2025 (AHA)

  3. Impact of Extracellular Volume on Transcutaneous GFR Measurement Accuracy in Male and Female rats

    Satoshi Shimada, Ranjan Dash, Allen Cowley Jr

    American Physiology Summit 2025

  4. Oxidative stress induced suppression of metabolism pathways in Dahl Salt-Sensitive rat

    Shimada, Satoshi, Yang, Chun, Dash, Ranjan K., Cowley Jr Allen W.

    ASN Kidney Week 2024

  5. Oxidative stress induced suppression of metabolism pathways in Dahl Salt-Sensitive rat

    Satoshi Shimada, Chun Yang, Ranjan K. Dash, Allen W. Cowley, J.

    Complex Trait Community--Rat Genomics 2024

  6. GFR, renal blood flow, and kidney metabolic responses to high salt intake in rats.

    Satoshi Shimada

    MCW Physiology Seminar Series　2024/09/18

  7. Renal hemodynamic and transcriptomic changes in response to salt in Dahl salt-sensitive rats

    Satoshi Shimada, Chun Yang, Ranjan K. Dash, Allen W. Cowley, J.

    Hypertension Scientific Sessions 2024 (AHA)

  8. High Salt Induced Alterations in Substrate Metabolism, Respiratory Activity, and Acidification in Isolated Proximal Tubules from Dahl Salt-Sensitive Rats

    Ranjan Dash, Chun Yang, Devanshi Dave, Theresa Kurth, Satoshi Shimada, Allen Cowley Jr

  9. NADPH Oxidase 4 Knockout in Dahl Salt-Sensitive Rats Impacts Kidney O2 Consumption and UCP2 Responses to a High Salt Diet

    Satoshi Shimada, Chun Yang, Ranjan Dash, Allen Cowley Jr

    American Physiology Summit 2024

  10. Dynamic shift towards increased O2 consumption and reduced lactate uptake during acute volume expansion in Sprague Dawley (SD) rats

    Satoshi Shimada, Chun Yang, Ranjan Dash, Allen Cowley Jr

    American Physiology Summit 2024

  11. High Salt Induced Mitochondrial Uncoupling And Enhanced Respiratory Activity In Isolated Proximal Tubules From Dahl Salt-sensitive Rats

    Chun Yang, Ranjan K Dash, Terry Kurth, Satoshi Shimada, Allen W Cowley Jr

    Hypertension Scientific Sessions 2023 (AHA)

  12. Evidence Of Increased Glycolysis In Renal Cortex Of High Salt Fed Sprague Dawley Rats

    Satoshi Shimada, Brian Hoffmann, Chun Yang, Theresa Kurth, Andrew Greene, Mingyu Liang, Ranjan K Dash, Allen W Cowley

    Hypertension Scientific Sessions 2023 (AHA)

  13. Impact Of NADPH Oxidase 4 Knockout On Renal O2 Consumption In Dahl Salt-sensitive Rats

    Satoshi Shimada, Ranjan K Dash, Allen W Cowley

  14. Alterations of Mitochondrial Respiratory Function in Isolated Nephron Segments of Dahl Salt-Sensitive Rats in Salt-Induced Hypertension

    Ranjan Dash, Chun Yang, Satoshi Shimada, Nadya Zheleznova, Allen Cowley Jr

    American Physiology Summit 2023

  15. The effects of excess salt intake on the kidney metabolism in normal Sprague Dawley rats

    Satoshi Shimada, Brian Hoffmann, Chun Yang, Theresa Kurth, Andrew Greene, Mingyu Liang, Ranjan Dash, Allen Cowley Jr

  16. Compensatory Changes in Oxygen Extraction and Metabolomic Profiles in the Kidney of Sprague-Dawley Rats fed a High-Salt Diet

    Satoshi Shimada

    MCW Physiology Seminar Series　2023/01/13

  17. Tubular Sites Of Mtorc2 Inhibition Of Sodium Transport In Dahl Salt-sensitive Rats.

    Allen W Cowley, Chun Yang, Olena Isaeva, Satoshi Shimada, Terry Kurth, Megan Stumpf, Alison J Kriegel, Ranjan K Dash

    Hypertension Scientific Sessions 2022 (AHA)

  18. Compensatory Changes in Metabolomic Profiles In The Kidney Of Sprague-Dawley Rats Fed A High-salt Diet

    Satoshi Shimada, Brian R Hoffmann, Andrew S Greene, Mingyu Liang, Ranjan K Dash, Allen W Cowley

    Hypertension Scientific Sessions 2022 (AHA)

  19. Compensatory Changes in Oxygen Extraction and Metabolomic Profiles in the Kidney of Sprague-Dawley Rats fed a High-Salt Diet

    Satoshi Shimada, Brian R. Hoffmann, Chun Yang, Theresa Kurth, Andrew S. Greene, Mingyu Liang, Dash K. Ranjan, Allen W. Cowley J.

    Control of Renal Function in Health and Disease Conference 2022 (APS/ASN)

  20. Metabolomic Kidney Input and Output Analyses in Salt‐Sensitive Hypertension

    Brian R Hoffmann, Satoshi Shimada, Andrew S Greene, Mingyu Liang, Ranjan Dash, Allen Cowley Jr

    2022 Exprimental Biology Conference

  21. Compensatory Changes in Oxygen Extraction and Metabolomic Profiles in the Kidney of Sprague-Dawley Rats fed a High-Salt Diet

    Satoshi Shimada, Brian Hoffmann, Andrew Greene, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley, J.

    2022 Exprimental Biology Conference

  22. Changes In Renal Oxygen Consumption with High-salt Diet Differ Between Sprague Dawley And Dahl Salt Sensitive Rats

    Satoshi Shimada, Ranjan K Dash, Allen W Cowley

    Hypertension Scientific Sessions 2021 (AHA)

  23. Acute Increases Of Renal Perfusion Pressure Activate Mechanistic Target Of Rapamycin Complex 1 And Increase Macrophage Infiltration In The Kidney Of Sprague Dawley Rats

    Satoshi Shimada, Chun Yang, Vikash Kumar, David L Mattson, Allen W Cowley

    Hypertension Scientific Sessions 2021 (AHA)

  24. Acute Elevation of Renal Perfusion Pressure Activates Mechanistic Target of Rapamycin Complex 1 (mTORC1) in Rats

    Satoshi Shimada, Vikash Kumar, Chun Yang, David L. Mattson, Allen W. Cowley, J.

    2021 Exprimental Biology Conference

  25. High Salt Diet Increases Renal Oxygen Consumption in Sprague-Dawley Rats

    Satoshi Shimada, Ranjan K. Dash, Allen W. Cowley Jr

    2021 Exprimental Biology Conference

  26. Role Of Angiotensin in Determining Blood Flow Remaining Kidney Following Nephrectomy

    Satoshi Shimada, Allen W. Cowley, J.

    Hypertension Scientific Sessions 2020 (AHA)

  27. Kidney mitochondrial redox state 3 days following uninephrectomy in rats determined by cyro-fluorescence optical imaging

    Allen W. Cowley Jr, Chun Yang, Satoshi Shimada, Nadya Zheleznova, Shima Mehrvar, Farnaz Foomani, Soudeh Mostaghimi, Mahsa Ranji

    2020 Exprimental Biology Conference

  28. Angiotensin II activates mTORC1 pathway in the kidneys through a pressor-independent mechanism

    Satoshi Shimada, Chun Yang, Vikash Kumar, Megan Stumpf, Theresa Kurth, David L. Mattson, Allen W. Cowley J.

    2020 Exprimental Biology Conference

  29. Elevated angiotensin II leads to renal capillary rarefaction and leukocyte infiltration which is dependent upon elevated renal perfusion pressure

    Satoshi Shimada, Justine M., Abais-Battad, Ammar J. Alsheikh, Chun Yang, Megan Stumpf, Theresa Kurth, David L. Mattson, Allen W. Cowley J.

    2020 Angiotensin GRC

  30. Defining Molecular Pathways Involved in the Early Compensatory Response of Healthy Kidneys to Contralateral Uninephrectomy

    Allen W. Cowley Jr, Satoshi Shimada, Chun Yang, Nadezhda Zheleznova, Theresa Kurth, Mahsa Ranji, Shima Mehrvar, Angela Mathison, Thiago Milech De Assuncao, Raul Urrutia

    2019 Control of Renal Function in Health and Disease Conference

  31. Renin-angiotensin responses initiate the early renal hemodynamic responses of healthy kidneys to uninephrectomy.

    Satoshi Shimada, Chun Yang, Theresa Kurth, Allen W. Cowley, J.

    2019 Control of Renal Function in Health and Disease Conference

  32. EXPRESSION OF (PRO)RENIN RECEPTOR IN RAT RENAL CONGESTION MODEL

    T. Hirose, S. Shimada, T. Matsuki, C. Takahashi, H. Nakamura, S. Kinugasa, Y. Muroya, J. Tani, S. Ito, T. Mori

    ISN WCN 2019

  33. IMATINIB ATTENUATES PERYCITE-MYOFIBROBLAST TRANSITION IN RENAL CONGESTION IN RATS

    T. MATSUKI, T. Hirose, S. Shimada, C. Takahashi, S. Kinugasa, Y. Muroya, H. Nakamura, J. Tani, S. Itoh, T. Mori

    ISN WCN 2019

  34. Reduction of circulating renin-angiotensin following uninephrectomy signals kidney hypertrophy via increase in renal blood flow

    Satoshi Shimada, Allen W. Cowley J.

    2019 Exprimental Biology Conference

  35. Pericyte Detachment is Involved in Renal Congestion in a Novel Rat Model

    Satoshi Shimada, Takuo Hirose, Chika Takahashi, Emiko Sato, Satoshi Kinugasa, Sadayoshi Ito, Takefumi Mori

    Hypertension Scientific Sessions 2018 (AHA)

  36. Pathophysiological analysis of renal congestion using a novel rat model

    Shimada S., Ohsaki Y., Takahashi C., Hirose T., Sato E., Ito S., Mori T.

    ISN frontiers meeting 2018

  37. Pathophysiological analysis of renal congestion using a novel rat model

    Shimada Satoshi, Mori Takefumi, Ohsaki Yusuke, Takahashi Chika, Ito Sadayoshi

    ASN Kidney Week 2017

  38. Glucose induces mitochondrial reactive oxygen species through carbonyl stress and respiratory chain in rat peritoneal mesothelial cells

    Satoshi Shimada, Yusuke Ohsaki, Chika Takahashi, Takefumi Mori, Sadayoshi Ito

    ASN Kidney Week 2015

  39. ラット腹膜中皮細胞におけるブドウ糖刺激によるミトコンドリア由来活性酸素種産生メカニズムの解明

    島田佐登志, 森建文, 大崎雄介, 矢花郁子, 伊藤貞嘉

    第59回日本腎臓学会学術総会

  40. Water and the Solute Removal in the Neutralizated Icodextrin Peritoneal Dialysis Fluid

    Satoshi Shimada, Takefumi Mori, Kenji Koizumi, Shinichi Sato, Ikuko Oba-Yabana, Yusuke Ohsaki, Emiko Sato, Eri Naganuma, Naho Kurasawa, Mihoko Tsuchikawa, Sadayoshi Ito

    36th Annual Dialysis Conference

  41. ブドウ糖およびGDPsはラット腹膜中皮細胞でミトコンドリア由来の活性酸素（ROS）を生じる

    島田佐登志, 森建文, 大崎雄介, 伊藤貞嘉

    第21回日本腹膜透析医学会学術集会・総会

  42. 心症状を主体とした間質性肺炎合併の抗ARS抗体症候群の1例

    島田佐登志, 城田祐子, 武藤智之, 秋田佳奈恵, 藤田洋子, 藤井博司, 石井智徳, 張替秀郎

    第25回日本リウマチ学会 北海道・東北支部学術集会

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Research Projects 3

  1. Effects of salt loading upon renal energy production, oxidative stress and injury

    Offer Organization: American Heart Association

    System: Career Development Award

    Institution: Medical College of Wisconsin

    2024/07 - 2027/06

  2. Impact of High Salt Diet on Kidney Oxygen and Substrate Metabolism

    Offer Organization: American Heart Association

    System: Postdoctoral Fellowship

    Institution: Medical College of Wisconsin

    2023/01 - 2025/12

  3. Physiological and molecular mechanisms underlying renal congestion in congestive heart failure

    MORI Takefumi, SHIMADA Satoshi, TAKAHASHI Chika

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku Medical and Pharmaceutical University

    2016/04/01 - 2019/03/31

    More details Close

    We created a rat renal congestion model and investigated the effect of renal congestion on hemodynamics and molecular mechanisms. Tubulointerstitial injury and medullary thick ascending limb hypoxia were observed only in the congestive kidneys. Using this rat congestion model and cell culture system, we revealed that vacuolar ATPase system in acidic organelles and pericyte injury were involved in the development of renal interstitial fibrosis due to renal congestion.