東北大学研究者紹介

研究者詳細

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日本語 English

顔写真

ウノ　カナメ

宇野　要

Kaname Uno

所属

大学院医学系研究科　医科学専攻　内科病態学講座（消化器病態学分野）

職名

講師

学位

医学博士（東北大学大学院）

researchmap

https://researchmap.jp/gastro1

J-GLOBAL ID

201801008235728515

経歴 1

2012年7月～ 2013年11月

Mayo Clinic, MN　消化器内科　客員研究員

所属学協会 2

アメリカ消化器病学会

2025年8月～継続中
日本食道学会

2025年5月～継続中

研究分野 1

ライフサイエンス / 消化器内科学 /

論文 145

Metabolic syndrome develops cardia cancer via nuclear factor-E2-related factor 2-programmed death-ligand 1 signaling 査読有り

Keisuke Kusano, Kaname Uno, Toru Tamahara, Naoki Asano, Koichiro Sudo, Mizuki Tanabe, Koya Ogasawara, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

Cellular and Molecular Gastroenterology and Hepatology　101629-101629　2025年9月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.jcmgh.2025.101629 　

ISSN：2352-345X
Co-stimulation with high-fat diet and acidic bile salts may promote Warburg effect in gastric carcinogenesis around the squamo-columnar junction in Gan mice 査読有り

Koichiro Sudo, Kaname Uno, Toru Tamahara, Naoki Asano, Keisuke Kusano, Mizuki Tanabe, Kouya Ogasawara, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

American Journal of Physiology-Gastrointestinal and Liver Physiology　2025年4月17日
出版者・発行元： American Physiological Society
DOI： 10.1152/ajpgi.00305.2024 　

ISSN：0193-1857

eISSN：1522-1547

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Epidemiological studies demonstrated relationships between gastric cardia adenocarcinoma (GCA) and metabolic syndrome (MetS). We aimed to clarify mechanism underlying their relationship. To investigate whether systemic inflammation against high-fat diet (HFD)-related dysbiosis promotes Warburg effect in tumors at the squamo-columnar junction (SCJ), we applied K19-Wnt1/C2mE (Gan) mice, fed either HFD or control diet ± acidic bile salts (ABS) with/without clodronate liposomes (CLs), and in vitro studies using MKN7 cells with/without THP1-derived macrophages. Then, we assessed involvement of oxidative stress (OS) in Warburg effect by comparing between nuclear factor-erythroid 2-related factor 2 (Nrf2) knockout-Gan mice and Gan mice. Tumors with macrophage infiltration in HFD+ABS group were larger than in Control group. Gene Set Enrichment Analysis revealed enhancement of the OS signaling in tumor of HFD+ABS group. HFD+ABS group mice demonstrated induction of OS, Nqo1, TNFα, and Warburg effect in tumors and mucosal barrier dysfunction of dysbiotic gut. All of them were abolished with diminishing macrophage infiltration by additional CLs treatment. Stimulation with TNFα, but not ABS nor lipopolysaccharide, on MKN7 cells activated Warburg effect. In MKN7 cells co-cultured with the macrophages whose TNFa expression was induced by the lipopolysaccharide pretreatment, Warburg effect was enhanced in the TNFα concentration-dependent manners. In Nrf2 knockout-Gan mice, tumors shrank with reducing OS, TNFα, and Warburg effect, along with decreasing macrophage infiltration. Accordingly, MetS may develop GCA through the Nrf2-related Warburg effect under the TNFα stimulation from the macrophages activated by both local ABS exposure and systemic lipopolysaccharide exposure from leaky gut with HFD-related dysbiosis.
Porphyromonas gingivalis Lipopolysaccharide Damages Mucosal Barrier to Promote Gastritis-Associated Carcinogenesis 国際誌査読有り

Masayoshi Oriuchi, Sujae Lee, Kaname Uno, Koichiro Sudo, Keisuke Kusano, Naoki Asano, Shin Hamada, Waku Hatta, Tomoyuki Koike, Akira Imatani, Atsushi Masamune

Digestive Diseases and Sciences　69　(1)　95-111　2023年11月9日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s10620-023-08142-6 　

ISSN：0163-2116

eISSN：1573-2568

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BACKGROUND: Recent epidemiological studies suggested correlation between gastric cancer (GC) and periodontal disease. AIMS: We aim to clarify involvement of lipopolysaccharide of Porphyromonas gingivalis (Pg.), one of the red complex periodontal pathogens, in the GC development. METHODS: To evaluate barrier function of background mucosa against the stimulations, we applied biopsy samples from 76 patients with GC using a Ussing chamber system (UCs). K19-Wnt1/C2mE transgenic (Gan) mice and human GC cell-lines ± THP1-derived macrophage was applied to investigate the role of Pg. lipopolysaccharide in inflammation-associated carcinogenesis. RESULTS: In the UCs, Pg. lipopolysaccharide reduced the impedance of metaplastic and inflamed mucosa with increases in mRNA expression of toll-like receptor (TLR) 2, tumor necrosis factor (TNF) α, and apoptotic markers. In vitro, Pg. lipopolysaccharide promoted reactive oxidative stress (ROS)-related apoptosis as well as activated TLR2-β-catenin-signaling on MKN7, and it increased the TNFα production on macrophages, respectively. TNFα alone activated TLR2-β-catenin-signaling in MKN7, while it further increased ROS and TNFα in macrophages. Under coculture with macrophages isolated after stimulation with Pg. lipopolysaccharide, β-catenin-signaling in MKN7 was activated with an increase in supernatant TNFα concentration, both of which were decreased by adding a TNFα neutralization antibody into the supernatant. In Gan mice with 15-week oral administration of Pg. lipopolysaccharide, tumor enlargement with β-catenin-signaling activation were observed with an increase in TNFα with macrophage infiltration. CONCLUSIONS: Local exposure of Pg. lipopolysaccharide may increase ROS on premalignant gastric mucosa to induce apoptosis-associated barrier dysfunction and to secrete TNFα from activated macrophages, and both stimulation of Pg. lipopolysaccharide and TNFα might activate TLR2-β-catenin-signaling in GC.
Development of Advanced Imaging and Molecular Imaging for Barrett's Neoplasia. 国際誌招待有り査読有り

Kaname Uno, Tomoyuki Koike, Waku Hatta, Masahiro Saito, Mizuki Tanabe, Atsushi Masamune

Diagnostics (Basel, Switzerland)　12　(10)　2022年10月8日

DOI： 10.3390/diagnostics12102437 　

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Barrett esophagus (BE) is a precursor to a life-threatening esophageal adenocarcinoma (EAC). Surveillance endoscopy with random biopsies is recommended for early intervention against EAC, but its adherence in the clinical setting is poor. Dysplastic lesions with flat architecture and patchy distribution in BE are hardly detected by high-resolution endoscopy, and the surveillance protocol entails issues of time and labor and suboptimal interobserver agreement for diagnosing dysplasia. Therefore, the development of advanced imaging technologies is necessary for Barrett's surveillance. Recently, non-endoscopic or endoscopic technologies, such as cytosponge, endocytoscopy, confocal laser endomicroscopy, autofluorescence imaging, and optical coherence tomography/volumetric laser endomicroscopy, were developed, but most of them are not clinically available due to the limited view field, expense of the equipment, and significant time for the learning curve. Another strategy is focused on the development of molecular biomarkers, which are also not ready to use. However, a combination of advanced imaging techniques together with specific biomarkers is expected to identify morphological abnormalities and biological disorders at an early stage in the surveillance. Here, we review recent developments in advanced imaging and molecular imaging for Barrett's neoplasia. Further developments in multiple biomarker panels specific for Barrett's HGD/EAC include wide-field imaging systems for targeting 'red flags', a high-resolution imaging system for optical biopsy, and a computer-aided diagnosis system with artificial intelligence, all of which enable a real-time and accurate diagnosis of dysplastic BE in Barrett's surveillance and provide information for precision medicine.
Acidic bile salts induces mucosal barrier dysfunction through let-7a reduction during gastric carcinogenesis after Helicobacter pylori eradication 査読有り

Yasushi Takahashi, Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Naoki Asano, Kiyotaka Asanuma, Tooru Shimosegawa

Oncotarget　9　(26)　18069-18083　2018年4月1日
出版者・発行元： Impact Journals LLC
DOI： 10.18632/oncotarget.24725 　

ISSN：1949-2553
Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression 査読有り

Junya Honda, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Takeharu Shiroki, Yutaka Kondo, Waku Hatta, Kaname Uno, Naoki Asano, Tomoyuki Koike, Tooru Shimosegawa

DIGESTIVE DISEASES AND SCIENCES　61　(4)　1028-1038　2016年4月

DOI： 10.1007/s10620-015-3980-6 　

ISSN：0163-2116

eISSN：1573-2568
Role of nitric oxide in the pathogenesis of Barrett's-associated carcinogenesis. 査読有り

Kusaka G, Uno K, Iijima K, Shimosegawa T

World journal of gastrointestinal pathophysiology　7　(1)　131-137　2016年2月

DOI： 10.4291/wjgp.v7.i1.131 　
Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies. 査読有り

Uno K, Koike T, Shimosegawa T

World journal of gastrointestinal endoscopy　7　(9)　872-880　2015年7月

DOI： 10.4253/wjge.v7.i9.872 　
Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm 査読有り

Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Tooru Shimosegawa

WORLD JOURNAL OF GASTROENTEROLOGY　21　(23)　7120-7133　2015年6月

DOI： 10.3748/wjg.v21.i23.7120 　

ISSN：1007-9327

eISSN：2219-2840
Prospective analysis of risk for bleeding after endoscopic biopsy without cessation of antithrombotics in Japan 査読有り

Nobuyuki Ara, Katsunori Iijima, Ryuhei Maejima, Yutaka Kondo, Gen Kusaka, Waku Hatta, Kaname Uno, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

DIGESTIVE ENDOSCOPY　27　(4)　458-464　2015年5月

DOI： 10.1111/den.12407 　

ISSN：0915-5635

eISSN：1443-1661
Endoscopic balloon dilatation for pharyngo-upper esophageal stricture after treatment of head and neck cancer 査読有り

Ryuhei Maejima, Katsunori Iijima, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Waku Hatta, Takenori Ogawa, Ken-ichi Watanabe, Yukio Katori, Tooru Shimosegawa

DIGESTIVE ENDOSCOPY　27　(3)　310-316　2015年3月

DOI： 10.1111/den.12345 　

ISSN：0915-5635

eISSN：1443-1661
Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy 査読有り

Kaname Uno, Katsuaki Kato, Tooru Shimosegawa

WORLD JOURNAL OF GASTROENTEROLOGY　20　(18)　5244-5251　2014年5月

DOI： 10.3748/wjg.v20.i18.5244 　

ISSN：1007-9327

eISSN：2219-2840
Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan 査読有り

Kenichiro Nakagawa, Tomoyuki Koike, Katsunori Iijima, Hirohiko Shinkai, Waku Hatta, Hiroyuki Endo, Nobuyuki Ara, Kaname Uno, Naoki Asano, Akira Imatani, Tooru Shimosegawa

AMERICAN JOURNAL OF GASTROENTEROLOGY　109　(3)　348-356　2014年3月

DOI： 10.1038/ajg.2013.450 　

ISSN：0002-9270

eISSN：1572-0241
Serious laryngeal edema during endoscopic resection for squamous cell carcinoma of the oesophagus. 査読有り

Ara Nobuyuki, Uno Kaname, Iijima Katsunori, Koike Tomoyuki, Asano Naoki, Shimosegawa Tooru

Endoscopy　45　(4)　313-315　2013年4月

DOI： 10.1055/s-0032-1325963 　
The role of nitric oxide in the induction of caudal-type homeobox 2 through epidermal growth factor receptor in the development of Barrett's esophagus 査読有り

Gen Kusaka, Kaname Uno, Katsunori Iijima, Hiroyuki Endo, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY　47　(10)　1148-1158　2012年10月

DOI： 10.3109/00365521.2012.703232 　

ISSN：0036-5521

eISSN：1502-7708
A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma 査読有り

Waku Hatta, Kaname Uno, Tomoyuki Koike, Katsunori Iijima, Naoki Asano, Akira Imatani, Tooru Shimosegawa

GASTROINTESTINAL ENDOSCOPY　76　(3)　548-555　2012年9月

DOI： 10.1016/j.gie.2012.05.012 　

ISSN：0016-5107
Direct Measurement of Gastroesophageal Reflux Episodes in Patients With Squamous Cell Carcinoma by 24-h pH-Impedance Monitoring 査読有り

Kaname Uno, Katsunori Iijima, Waku Hatta, Tomoyuki Koike, Yasuhiko Abe, Naoki Asano, Gen Kusaka, Tooru Shimosegawa

AMERICAN JOURNAL OF GASTROENTEROLOGY　106　(11)　1923-1929　2011年11月

DOI： 10.1038/ajg.2011.282 　

ISSN：0002-9270
The Balance Between 4-Hydroxynonenal and Intrinsic Glutathione/Glutathione S-Transferase A4 System May Be Critical for the Epidermal Growth Factor Receptor Phosphorylation of Human Esophageal Squamous Cell Carcinomas 査読有り

Kaname Uno, Katsuaki Kato, Gen Kusaka, Naoki Asano, Katsunori Iijima, Tooru Shimosegawa

MOLECULAR CARCINOGENESIS　50　(10)　781-790　2011年10月

DOI： 10.1002/mc.20699 　

ISSN：0899-1987

eISSN：1098-2744
Gastric acid secretion level modulates the association between Helicobacter pylori infection and low-dose aspirin-induced gastropathy 査読有り

Katsunori Iijima, Nobuyuki Ara, Yasuhiko Abe, Tomoyuki Koike, Wataru Iwai, Kaname Uno, Naoki Asano, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY　46　(5)　612-619　2011年5月

DOI： 10.1007/s00535-011-0385-y 　

ISSN：0944-1174
Gastric hyposecretion in esophageal squamous-cell carcinomas. 査読有り

Iijima K, Koike T, Abe Y, Yamagishi H, Ara N, Asanuma K, Uno K, Imatani A, Nakaya N, Ohara S, Shimosegawa T

Digestive diseases and sciences　55　(5)　1349-1355　2010年5月
出版者・発行元： 5
DOI： 10.1007/s10620-009-0853-x 　

ISSN：0163-2116
Optical coherence tomography for the staging of tumor infiltration in superficial esophageal squamous cell carcinoma 査読有り

Waku Hatta, Kaname Uno, Tomoyuki Koike, Satoshi Yokosawa, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa

GASTROINTESTINAL ENDOSCOPY　71　(6)　899-906　2010年5月

DOI： 10.1016/j.gie.2009.11.052 　

ISSN：0016-5107
Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication 査読有り

Katsunori Iijima, Tomoyuki Koike, Hitoshi Sekine, Yasuhiko Abe, Kiyotaka Asanuma, Nobuyuki Ara, Kaname Uno, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY　44　(1)　47-55　2009年1月

DOI： 10.1007/s00535-008-2270-x 　

ISSN：0944-1174
Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells 査読有り

Kaname Uno, Katsuaki Kato, Tomoaki Atsumi, Takehito Suzuki, Jun Yoshitake, Hidetoshi Morita, Shuichi Ohara, Yashige Kotake, Tooru Shimosegawa, Tetsuhiko Yoshimura

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　293　(5)　G1004-G1012　2007年11月

DOI： 10.1152/ajpgi.00096.2007 　

ISSN：0193-1857
Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer 査読有り

Tomoaki Atsumi, Katsuaki Kato, Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Akira Imatani, Syuichi Ohara, Tooru Shimosegawa

PATHOLOGY INTERNATIONAL　57　(10)　635-644　2007年10月

DOI： 10.1111/j.1440-1827.2007.02152.x 　

ISSN：1320-5463
In vivo study on cross talk between inducible nitric-oxide synthase and cyclooxygenase in rat gastric mucosa: Effect of cyclooxygenase activity on nitric oxide production 査読有り

K Uno, Y Iuchi, J Fujii, H Sugata, K Iijima, K Kato, T Shimosegawa, T Yoshimura

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　309　(3)　995-1002　2004年6月

DOI： 10.1124/jpet.103.061283 　

ISSN：0022-3565
Antibiotics treatment promotes squamocolumnar junction tumor progression via tumor immune evasion in K19-Wnt1/C2mE mice fed high-fat diet and acidic bile salts

Koya Ogasawara, Kaname Uno, Toru Tamahara, Naoki Asano, Koichiro Sudo, Keisuke Kusano, Mizuki Tanabe, Yumiko Kaise, Takafumi Shindo, Yusuke Shimoyama, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

American Journal of Physiology-Gastrointestinal and Liver Physiology　2026年5月22日
出版者・発行元： American Physiological Society
DOI： 10.1152/ajpgi.00056.2026 　

ISSN：0193-1857

eISSN：1522-1547

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Clinical studies suggested that antibiotics (ABx) administration might increase esophagogastric junction adenocarcinoma risk, but the underlying mechanisms remain unclear. We previously demonstrated that the administration of a high-fat diet (HFD) and acid bile salts (ABS) to K19-Wnt1/C2mE mice might promote the metabolic-driven tumor growth at the squamocolumnar junction (SCJ) cooperatively with gut dysbiosis. To clarify whether ABx-induced dysbiosis promotes the tumorigenesis, we evaluated the effects of HFD+ABS ± ABx treatment on tumor immune evasion in mice. In HFD+ABS+ABx-treated mice, SCJ tumor growth with increased tumor cell proliferation and infiltration of inflammatory cells positive for CD8, programmed cell death protein 1 and programmed cell death-ligand 1 (PD-L1) were observed along with apoptosis suppression. Protein expressions of interferon-gamma (IFNγ) and phosphorylated signal transducer and activator of transcription (p-STAT) 3 were upregulated in the tumors of the HFD+ABS+ABx group, whose p-STAT1 expression was equivalent to that of the control group. The mice exhibited insulin resistance and metabolic endotoxemia, and metagenomic analysis of their ileal excrement revealed dysbiosis with a decrease in butyrate-producing bacteria and bacterial butanoate metabolism activity. Moreover, IFNγ stimulation of human-derived NUGC-4 cells increased the protein expression of PD-L1, p-STAT1 and p-STAT3, all of which decreased in response to STAT inhibitors. Transfection with small interfering RNA targeting STAT1 or STAT3 did not attenuate PD-L1 induction, which was inhibited by the combined knockdown. Therefore, oral HFD+ABS+ABx administration to K19-Wnt1/C2mE mice may promote SCJ tumors through tumor immune evasion via IFNγ–STAT1/STAT3–PD-L1 signaling, along with metabolic endotoxemia.
High-fidelity endoscopic submucosal dissection simulator reproducing full-procedure training, bleeding, and perforation

Takeshi Kanno, Yutaka Hatayama, Suguo Suzuki, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

Endoscopy　58　(S 01)　E23-E25　2026年1月8日
出版者・発行元： Georg Thieme Verlag KG
DOI： 10.1055/a-2761-0309 　

ISSN：0013-726X

eISSN：1438-8812
Epidemiology of dyspepsia and esophagogastroduodenoscopic findings in the era of Helicobacter pylori eradication

Suguo Suzuki, Takeshi Kanno, Tomoyuki Koike, Takashi Chiba, Kiyotaka Asanuma, Katsuaki Kato, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Waku Hatta, Kaname Uno, Akira Imatani, Atsushi Masamune

World Journal of Gastroenterology　31　(37)　2025年10月7日
出版者・発行元： Baishideng Publishing Group Inc.
DOI： 10.3748/wjg.v31.i37.110942 　

ISSN：1007-9327

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BACKGROUND Since Japanese national insurance coverage was expanded to include Helicobacter pylori (H. pylori ) gastritis in 2013, approximately 1.5 million patients have received eradication therapy annually. However, the prevalence and clinical features of uninvestigated dyspepsia in the post-eradication era remain unclear. AIM To evaluate the prevalence of dyspepsia and related endoscopic findings in the general population. METHODS We analyzed data from a gastric cancer screening program using esophagogastroduodenoscopy in Sendai city between 2019 and 2021. Data regarding endoscopic findings, upper gastrointestinal symptoms, and history of H. pylori eradication were collected. Dyspepsia was defined as the presence of upper abdominal pain, bloating, or both. Multivariate logistic regression was used to identify independent factors associated with dyspepsia. RESULTS Among 23250 participants, overall dyspepsia prevalence was 28.0%. It was 28.7% in the non-infected and post-eradication cohorts, and lower (25.8%, P < 0.05) in the currently infected or naturally eradicated cohort. In addition, 23.1% of participants reported heartburn. The following were independently associated with dyspepsia: Age < 60 years, female sex, gastric ulcers, duodenal ulcers, erosive esophagitis, a history of gastric surgery, and successful H. pylori eradication. Gastric or esophageal cancer showed no association. CONCLUSION Uninvestigated dyspepsia remains common even after successful H. pylori eradication. Dyspepsia was not considered a reliable indicator of gastric or esophageal cancer.
Etiology and pathophysiology of Barrett's esophagus/neoplasia. 招待有り査読有り

Asano N., Koike T., Saito M., Hatayama Y., Ogata Y., Jin X., Kanno T., Hatta W., Uno K., Imatani A., Masamune A.

Digestion　15　1-14　2025年9月

DOI： 10.1159/000548413 　
ダブルバルーン内視鏡下静脈瘤硬化療法が有効であった出血性空腸静脈瘤の1例

梶浦大貴, 宇野要, 小池智幸, 粂潔, 畑山裕, 齋藤真弘, 小黒草太, 滝戸成人, 藤尾淳, 尾形洋平, 八田和久, 下山雄丞, 志賀永嗣, 二宮匡史, 今谷晃, 高瀬圭, 亀井尚, 正宗淳

日本門脈圧亢進症学会雑誌　31　(3)　143-143　2025年8月
出版者・発行元： (一社)日本門脈圧亢進症学会
ISSN：1344-8447

eISSN：2186-6376
ダブルバルーン内視鏡下静脈瘤硬化療法が有効であった出血性空腸静脈瘤の1例

梶浦大貴, 宇野要, 小池智幸, 粂潔, 畑山裕, 齋藤真弘, 小黒草太, 滝戸成人, 藤尾淳, 尾形洋平, 八田和久, 下山雄丞, 志賀永嗣, 二宮匡史, 今谷晃, 高瀬圭, 亀井尚, 正宗淳

日本門脈圧亢進症学会雑誌　31　(3)　143-143　2025年8月
出版者・発行元： (一社)日本門脈圧亢進症学会
ISSN：1344-8447

eISSN：2186-6376
Usefulness of double-balloon endoscopy-assisted injection sclerotherapy for hemorrhagic varices in the jejunum reconstructed for liver transplantation in a pediatric case.

Hiroki Kajiura, Kaname Uno, Kiyoshi Kume, Tomoyuki Koike, Masahiro Saito, Yusuke Shimoyama, Masashi Ninomiya, Sota Oguro, Kei Takase, Atsushi Masamune

Clinical journal of gastroenterology　18　(4)　619-625　2025年8月

DOI： 10.1007/s12328-025-02150-x 　

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A 10-year-old girl was admitted to our hospital for treatment of recurrent melena and severe anemia. Her treatment history comprised Kasai's portoenterostomy for biliary atresia as an infant, followed by liver transplantation and partial splenectomy for portal hypertension at 1 year old. Her medications comprised steroids, immunosuppressive agents, a β-blocker, and a potassium-competitive acid blocker. Since the age of 5 years, she had repeatedly visited a local hospital for melena, but the bleeding source had not been identified. She was referred to our hospital, and laboratory data revealed severe anemia. An enhanced computed tomography showed post-liver transplantation status, splenomegaly, and gastric varices, without extravasation. Esophagogastroduodenoscopy and colonoscopy did not identify the bleeding source. Double-balloon endoscopy (DBE) revealed variceal bleeding and serosanguinous fluid accumulated at the choledochojejunostomy site in the jejunum. After obtaining informed consent, our team and the radiologists cooperatively performed DBE-assisted endoscopic injection sclerotherapy with 75% n-butyl-2-cyanoacrylate through a 23- gage needle according to high-resolution varicerography in a hybrid emergency room. Subsequently, the patient was discharged and regularly monitored without any complications. We demonstrated the first pediatric case of successful DBE-assisted endoscopic injection for hemorrhagic jejunal varices after liver transplantation for biliary atresia and partial splenectomy.
長期間のステロイド投与を要した好酸球性胃腸炎が、慢性副鼻腔炎に対するデュピルマブ投与により寛解した1例

清水翔太, 齊藤真弘, 小池智幸, 皆瀬ゆみ子, 小泉薫, 畑山裕, 尾形洋平, 菅野武, 八田和久, 宇野要, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　219回　79-79　2025年7月
出版者・発行元：日本消化器病学会-東北支部
日本と海外におけるバレット食道・バレット食道癌の違い表在型Barrett食道癌(BA)単発例と多発例における逆流因子及び内視鏡的特徴の検討

小泉薫, 齊藤真弘, 小池智幸, 皆瀬ゆみ子, 菅原英之, 首藤千博, 谷地一真, 八田和久, 宇野要, 正宗淳

日本食道学会学術集会プログラム・抄録集　79回　45-45　2025年6月
出版者・発行元： (NPO)日本食道学会
特発性食道潰瘍がHIV感染症の発見契機となった1例

菅原英之, 齊藤真弘, 宇野要, 遠藤悠生, 畑山裕, 尾形洋平, 八田和久, 小池智幸, 正宗淳

日本食道学会学術集会プログラム・抄録集　79回　119-119　2025年6月
出版者・発行元： (NPO)日本食道学会
日本と海外におけるバレット食道・バレット食道癌の違い表在型Barrett食道癌(BA)単発例と多発例における逆流因子及び内視鏡的特徴の検討

小泉薫, 齊藤真弘, 小池智幸, 皆瀬ゆみ子, 菅原英之, 首藤千博, 谷地一真, 八田和久, 宇野要, 正宗淳

日本食道学会学術集会プログラム・抄録集　79回　45-45　2025年6月
出版者・発行元： (NPO)日本食道学会
特発性食道潰瘍がHIV感染症の発見契機となった1例

菅原英之, 齊藤真弘, 宇野要, 遠藤悠生, 畑山裕, 尾形洋平, 八田和久, 小池智幸, 正宗淳

日本食道学会学術集会プログラム・抄録集　79回　119-119　2025年6月
出版者・発行元： (NPO)日本食道学会
Associations between excessive supragastric belching and esophageal reflux factors in patients with PPI-refractory GERD in Japan. 査読有り

Yukihiro Shuto, Masahiro Saito, Tomoyuki Koike, Kaoru Koizumi, Yumiko Kaise, Kazuma Yachi, Yutaka Hatayama, Yohei Ogata, Xiaoyi Jin, Takeshi Kanno, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

Journal of gastroenterology　2025年5月12日

DOI： 10.1007/s00535-025-02258-4 　

詳細を見る詳細を閉じる

BACKGROUND: No studies have evaluated the prevalence of supragastric belching (SGB) in Japanese patients with proton pump inhibitor (PPI)-refractory non-erosive reflux disease (NERD) under off-PPI conditions. This study aimed to clarify the association between excessive SGB and esophageal reflux factors. METHODS: Seventy-nine patients with PPI-refractory NERD under off-PPI treatment were evaluated using 24-h multichannel intraluminal impedance pH monitoring and high-resolution impedance manometry. RESULTS: The prevalence values of excessive SGB overall and in the true NERD, reflux hypersensitivity, and function heartburn subtypes were 19.0%, 35.7%, 5.3%, and 12.5%, respectively. The monitoring results demonstrated that, compared with those without excessive SGB, patients with excessive SGB had a significantly higher total number of reflux events (63 episodes vs. 39 episodes, p = 0.01) and significantly greater acid exposure time (6.1% vs. 1.35%, p = 0.01). However, bolus exposure did not differ significantly between the groups (p = 0.09). The manometry findings showed no significant differences in lower esophageal sphincter pressure, integrated relaxation pressure, and distal contractile integral between the groups. Regarding gastroesophageal reflux, 22% of the SGB episodes were preceded by reflux, 55% occurred independently, and 23% were followed by reflux. CONCLUSIONS: The prevalence of excessive SGB in Japanese patients with PPI-refractory NERD under off-PPI conditions was 19.0% and most commonly observed in patients with true NERD (35.7%). Patients with excessive SGB exhibited increased esophageal acid exposure, and reflux events were sometimes observed before SGB episodes.
食道疾患に対する内視鏡診療の新展開頭頸部癌・食道癌治療後狭窄患者における,新型細径処置スコープEG-840TPを用いた上部消化管ESDの検討

尾形洋平, 八田和久, 小池智幸, 畑山裕, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 今谷晃, 正宗淳

日本気管食道科学会会報　76　(2)　85-85　2025年4月
出版者・発行元： (NPO)日本気管食道科学会
ISSN：0029-0645

eISSN：1880-6848
機能性消化管疾患の病態と診療の展開 PPI抵抗性NERD患者におけるexcessive supragastric belchingと食道内逆流因子の関連についての検討

首藤千博, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 谷地一真, 八田和久, 宇野要, 今谷晃, 正宗淳

日本消化器病学会雑誌　122　(臨増総会)　A52-A52　2025年3月
出版者・発行元： (一財)日本消化器病学会
ISSN：0446-6586

eISSN：1349-7693
消化管疾患の病態理解を深める研究経口抗生剤投与が腸管バリア傷害を増悪し食道胃接合部腺癌を進展させる

小笠原光矢, 須藤洸一郎, 宇野要, 玉原亨, 浅野直喜, 正宗淳

日本消化器病学会雑誌　122　(臨増総会)　A194-A194　2025年3月
出版者・発行元： (一財)日本消化器病学会
ISSN：0446-6586

eISSN：1349-7693
メタ解析による胃NET Rindi分類におけるリンパ節転移率の比較検討

尾形洋平, 八田和久, 菅野武, 畑山裕, 齊藤真弘, 金笑奕, 宇野要, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会雑誌　122　(臨増総会)　A364-A364　2025年3月
出版者・発行元： (一財)日本消化器病学会
ISSN：0446-6586

eISSN：1349-7693
多発性内分泌腫瘍症1型を併存する多発十二指腸非機能性NETの一例

加宅田公子, 八田和久, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 小池智幸, 今谷晃, 正宗淳

日本消化器内視鏡学会東北支部例会　173回　106-106　2025年2月
出版者・発行元：日本消化器内視鏡学会-東北支部
生体肝移植術後空腸静脈瘤出血に対し内視鏡的静脈瘤硬化療法を行った1例

梶浦大貴, 宇野要, 粂潔, 畑山裕, 齊藤真弘, 小池智幸, 尾形洋平, 金笑奕, 菅野武, 八田和久, 下山雄丞, 志賀永嗣, 二宮匡史, 今谷晃, 正宗淳

日本消化器内視鏡学会東北支部例会　173回　107-107　2025年2月
出版者・発行元：日本消化器内視鏡学会-東北支部
消化器疾患診療の現状と近未来・上部消化管・その他の部細径処置スコープEG-840TPを用いた,咽喉頭癌・食道癌治療後狭窄を有する症例における上部消化管ESDの検討

尾形洋平, 八田和久, 小池智幸, 畑山裕, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　218回　97-97　2025年2月
出版者・発行元：日本消化器病学会-東北支部
消化器疾患における基礎研究の役割と展望歯周病と胃癌罹患との関連性に関する検討

小笠原光矢, 宇野要, 浅野直喜, 小池智幸, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　218回　116-116　2025年2月
出版者・発行元：日本消化器病学会-東北支部
PPI抵抗性NERD患者におけるexcessive supragastric belchingと食道内逆流の関連についての検討

首藤千博, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 谷地一真, 畑山裕, 尾形洋平, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　218回　148-148　2025年2月
出版者・発行元：日本消化器病学会-東北支部
Barrett食道腺癌における食道運動機能の検討

谷地一真, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 首藤千博, 畑山裕, 尾形洋平, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　218回　148-148　2025年2月
出版者・発行元：日本消化器病学会-東北支部
胃穿破を来した膵臓・胃動静脈奇形に対し,内視鏡的止血後に根治的外科切除術を施行した1例

尾形洋平, 畑山裕, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 宇野要, 小池智幸, 今谷晃, 前田晋平, 水間正道, 海野倫明, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　218回　151-151　2025年2月
出版者・発行元：日本消化器病学会-東北支部
【基礎から学ぶ咽頭・食道内視鏡診断】病変拾い上げのコツ食道胃接合部観察の基本とコツ

小池智幸, 齊藤真弘, 八田和久, 小泉薫, 皆瀬ゆみ子, 谷地一真, 首藤千博, 宇野要, 正宗淳

消化器内視鏡　37　(1)　57-64　2025年1月
出版者・発行元： (株)東京医学社
ISSN：0915-3217
H.pylori感染状態とディスペプシアの頻度成人胃がん検診事業データに基づく疫学的分析

菅野武, 鈴木直生, 小池智幸, 千葉隆士, 淺沼清孝, 加藤勝章, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本ヘリコバクター学会誌　26　(2)　94-96　2025年1月
出版者・発行元： (一社)日本ヘリコバクター学会
ISSN：2187-8005
機能性消化管疾患～最新の診断と治療～[これまでの軌跡と新展開] PPI抵抗性NERD患者におけるexcessive supragastric belchingと食道内逆流因子の関連についての検討

首藤千博, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 谷地一真, 畑山裕, 尾形洋平, 八田和久, 宇野要, 今谷晃, 正宗淳

日本消化管学会雑誌　9　(Suppl.)　118-118　2025年1月
出版者・発行元： (一社)日本消化管学会
ISSN：2433-3840

eISSN：2435-8967
Optimal direct oral anticoagulant for upper gastrointestinal endoscopic submucosal dissection. 査読有り

Yoshitaka Ono, Waku Hatta, Kunio Tarasawa, Yohei Ogata, Hiroko Abe, Isao Sato, Yutaka Hatayama, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Tomoyuki Koike, Akira Imatani, Shin Hamada, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

Journal of gastroenterology　60　(1)　66-76　2025年1月

DOI： 10.1007/s00535-024-02171-2 　

詳細を見る詳細を閉じる

BACKGROUND: The patients taking direct oral anticoagulants (DOACs) are at high risk for developing ischemic stroke and delayed bleeding in upper gastrointestinal endoscopic submucosal dissection (ESD). We aimed to identify the optimal DOAC based on both adverse events in upper gastrointestinal ESD. METHODS: A retrospective population-based cohort study was conducted using the Diagnosis Procedure Combination database in Japan. We included patients on a DOAC undergoing upper gastrointestinal ESD between 2012 and 2021. The primary outcomes were ischemic stroke occurring after upper gastrointestinal ESD and delayed bleeding in gastroduodenal and esophageal ESD. Inverse probability weightings were applied to balance the four DOAC groups (dabigatran, rivaroxaban, apixaban, and edoxaban), and logistic regression analyses were performed to compare the outcomes. RESULTS: We analyzed 9729 patients on a DOAC undergoing upper gastrointestinal ESD. Ischemic stroke developed after upper gastrointestinal ESD in 1.4%, 0.7%, 0.6%, and 0.8% of patients taking dabigatran, rivaroxaban, apixaban, and edoxaban, respectively, after weighting. Rivaroxaban and apixaban showed significantly lower risk of ischemic stroke compared with dabigatran (odds ratio, 0.15 and 0.12, respectively) in standard doses. The delayed bleeding developed after gastroduodenal ESD in 7.6%, 14.6%, 19.2%, and 17.3% of patients taking each DOAC, respectively, with the lowest risk in dabigatran, followed by rivaroxaban. A similar pattern was observed in delayed bleeding in esophageal ESD (3.2%, 5.4%, 7.5%, and 5.5% in each DOAC), but with no significant results. CONCLUSIONS: Rivaroxaban might be an optimal DOAC for upper gastrointestinal ESD showing a lower risk for both ischemic stroke and delayed bleeding.
高リスク患者における,blue light imaging,linked color imagingによる食道扁平上皮癌スクリーニング多施設共同ランダム化比較試験

尾形洋平, 八田和久, 小池智幸, 高橋壮, 松橋保, 及川智之, 岩井渉, 阿曽沼祥, 大方英樹, 大矢内幹, 伊藤博敬, 阿部靖彦, 佐々木悠, 川村昌司, 齊藤真弘, 宇野要, 藤島史喜, 中村智洋, 中谷直樹, 飯島克則, 正宗淳

Gastroenterological Endoscopy　66　(12)　2694-2705　2024年12月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN：0387-1207

eISSN：1884-5738
A case of esophagogastric submucosal hematoma with hemorrhagic shock. 査読有り

Yumiko Kaise, Kaname Uno, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Tomoyuki Koike, Hideki Ota, Kei Takase, Atsushi Masamune

Clinical journal of gastroenterology　2024年11月21日

DOI： 10.1007/s12328-024-02069-9 　

詳細を見る詳細を閉じる

A 70-year-old woman had been taking steroids for granulomatosis with polyangiitis since the age of 60 years and warfarin for deep vein thrombosis since the age of 63 years. She was admitted to the emergency unit of our hospital in a shock vital with complaints of sudden onset of epigastralgia, nausea, and melena. Laboratory data revealed anemia, hypoalbuminemia, and coagulation disorders. Enhanced computed tomography demonstrated extravasation in the middle part of the gastric body in an extensive submucosal hematoma extending from the upper esophagus to the entire gastric body. Emergency esophagogastroduodenoscopy depicted a large submucosal hematoma and a large amount of fresh blood in the stomach; however, active bleeding was not identified. Two sessions of interventional radiology treatment in the emergency department, followed by an intensive care, successfully treated the patient without any complications. We report a unique case of a sudden-onset esophagogastric submucosal hematoma with hemorrhagic shock requiring an intensive care and interventional radiology treatment. In this case, the extensive warfarization and the fragility in vascular and connective tissue components in the submucosa due to the long-term steroid therapy and the granulomatosis with polyangiitis-related alteration might comprehensively cause severe esophagogastric submucosal hematoma even without any apparent triggers.
A Case of Superficial Esophageal Neuroendocrine Carcinoma with Marked Morphological Changes in a Short Period. 査読有り

Mizuki Tanabe, Masahiro Saito, Kaname Uno, Tomoyuki Koike, Chiaki Sato, Waku Hatta, Naoki Asano, Fumiyoshi Fujishima, Takashi Kamei, Atsushi Masamune

Internal medicine (Tokyo, Japan)　2024年11月1日

DOI： 10.2169/internalmedicine.4344-24 　

詳細を見る詳細を閉じる

A de novo whitish subepithelial lesion (SEL) with irregular vascular hyperplasia was detected in the lower thoracic esophagus during endoscopic surveillance. Special types of esophageal cancer were suspected; however, endoscopic biopsy specimens were inadequate for a diagnosis. Ten days later, endoscopic ultrasound showed a 7-mm homogeneously hypoechoic round mass in the submucosa, and a biopsy confirmed a histological diagnosis of esophageal neuroendocrine carcinoma (eNEC). Based on the clinical diagnosis of cT2N0M0, subtotal esophagectomy followed by adjuvant chemotherapy was performed immediately after endoscopic reexamination revealing a 20-mm reddish SMT. We herein report the marked changes in endoscopic findings of eNEC within 1.5 months.
【スキルアップ内視鏡診療】胃・十二指腸治療胃ESD後出血予防と対策あれこれ

八田和久, 小池智幸, 尾形洋平, 宇野要, 正宗淳

消化器内視鏡　36　(増刊)　162-166　2024年10月
出版者・発行元： (株)東京医学社
ISSN：0915-3217
表在型Barrett食道癌の発見契機と特徴に関する検討

小泉薫, 齊藤真弘, 小池智幸, 谷地一真, 首藤千博, 皆瀬ゆみ子, 畑山裕, 尾形洋平, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器がん検診学会雑誌　62　(Suppl大会)　744-744　2024年10月
出版者・発行元： (一社)日本消化器がん検診学会
ISSN：1880-7666

eISSN：2185-1190
予後予測のための新規基礎疾患スコア

佐藤伊佐雄, 八田和久, 中谷久美, 中谷直樹, 尾形洋平, 齊藤真弘, 金笑奕, 宇野要, 小池智幸, 今谷晃, 中村智洋, 正宗淳, 寳澤篤

日本消化器病学会雑誌　121　(臨増大会)　A831-A831　2024年10月
出版者・発行元： (一財)日本消化器病学会
ISSN：0446-6586

eISSN：1349-7693
大学病院における経皮内視鏡的胃瘻造設術の年次推移と合併症の変化

小笠原光矢, 金笑奕, 小池智幸, 矢野翔太, 阿部寛子, 尾形洋平, 齊藤真弘, 八田和久, 宇野要, 正宗淳

在宅医療と内視鏡治療　27　(1)　21-29　2024年9月
出版者・発行元： PEG・在宅医療学会
ISSN：1343-1544

eISSN：2758-2299
大学病院における経皮内視鏡的胃瘻造設術の年次推移と合併症の変化査読有り

小笠原光矢, 金笑奕, 小池智幸, 矢野翔太, 阿部寛子, 尾形洋平, 齊藤真弘, 八田和久, 宇野要, 正宗淳

在宅医療と内視鏡治療　27　(1)　21-29　2024年9月
出版者・発行元： PEG・在宅医療学会
ISSN：1343-1544

eISSN：2758-2299
A Case of Gastric Leiomyosarcoma Completely Resected by Endoscopic Submucosal Dissection after a Precise Preoperative Diagnosis. 査読有り

Kazuma Yachi, Waku Hatta, Tomoyuki Koike, Kimiko Kayada, Naotaro Tanno, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Naoki Asano, Akira Imatani, Hirofumi Watanabe, Fumiyoshi Fujishima, Atsushi Masamune

Internal medicine (Tokyo, Japan)　2024年8月1日

DOI： 10.2169/internalmedicine.3645-24 　

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A 68-year-old woman was diagnosed with leiomyosarcoma (LMS) based on preoperative biopsy of the gastric body. As tumor invasion confined to the submucosa with no breaking of the submucosal layer was confirmed on endoscopic ultrasonography (EUS), the patient underwent endoscopic submucosal dissection (ESD) for gastric LMS, resulting in complete tumor resection. No apparent recurrence was observed in the 2.5 years after treatment. This is an extremely rare case of gastric LMS that underwent ESD after a precise preoperative diagnosis, with no signs of recurrence after treatment. ESD may be an acceptable option for gastric LMS when EUS findings allow this treatment method.
The usefulness of gel immersion endoscopy in identifying herald bleeding from an infectious aortoenteric fistula: a case report. 査読有り

Suguo Suzuki, Masahiro Saito, Kaname Uno, Naoki Asano, Tomoyuki Koike, Daijirou Akamatsu, Masamichi Mizuma, Takashi Kamei, Michiaki Unno, Atsushi Masamune

Clinical journal of gastroenterology　2024年7月23日

DOI： 10.1007/s12328-024-02020-y 　

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A 62-year-old male with a history of stent graft replacement for an infectious aortic aneurysm, followed by multiple interventions for postoperative complications, was admitted with melena and anemia. Enhanced computed tomography (eCT) demonstrated fluffing and hyperdensities surrounding the graft, despite no evidence of an aortoenteric fistula (AEF). Emergency esophagogastroduodenoscopy (EGD) showed a massive bleeding in the reconstructed tract and the protruding lesion of postoperative granulation tissue with clots at the end of the blind pouch. Thereafter, hemorrhage temporarily reoccurred several times; however, the source could not be identified using eCT or EGD. Finally, on the third attempt, we performed gel immersion endoscopy (GIE) with manual injection of VISCOCLEARⓇ, and it showed purulent blood flowing from one side of the protruding lesion in the pouch. Based on the eCT findings showing exudation of the contrast agent from the graft into the pouch, we made a diagnosis of an AEF. However, radical surgery was not performed because of the patient's poor general condition. During conservative management, he died of uncontrolled bleeding from the AEF on the 5th day of hospitalization. This is the first case in which the GIE might provide tips to identify herald bleeding from a lethal AEF.
The Impact of Tobacco Smoking and Alcohol Consumption on the Development of Gastric Cancers. 国際誌招待有り査読有り

Waku Hatta, Tomoyuki Koike, Naoki Asano, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Akira Imatani, Atsushi Masamune

International journal of molecular sciences　25　(14)　2024年7月18日

DOI： 10.3390/ijms25147854 　

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Chronic infection of Helicobacter pylori is considered the principal cause of gastric cancers, but evidence has accumulated regarding the impact of tobacco smoking and alcohol consumption on the development of gastric cancers. Several possible mechanisms, including the activation of nicotinic acetylcholine receptors, have been proposed for smoking-induced gastric carcinogenesis. On the other hand, local acetaldehyde exposure and ethanol-induced mucosal inflammation have been proposed as the mechanisms involved in the development of gastric cancers in heavy alcohol drinkers. In addition, genetic polymorphisms are also considered to play a pivotal role in smoking-related and alcohol-related gastric carcinogenesis. In this review, we will discuss the molecular mechanisms involved in the development of gastric cancers in relation to tobacco smoking and alcohol consumption.
術前確定診断が困難であったEBV関連リンパ球浸潤胃癌の一例

丹野尚太郎, 八田和久, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　217回　91-91　2024年7月
出版者・発行元：日本消化器病学会-東北支部
Risk stratification of synchronous gastric cancers including alcohol-related genetic polymorphisms. 国際誌査読有り

Sho Asonuma, Waku Hatta, Tomoyuki Koike, Hideki Okata, Kaname Uno, Wataru Iwai, Masashi Saito, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Hirotaka Ito, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Shusuke Toda, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Kenji Kinoshita, Madoka Kisoi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

Journal of gastroenterology and hepatology　2024年4月16日

DOI： 10.1111/jgh.16570 　

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BACKGROUND AND AIM: We previously identified that ever-smoking and severe gastric atrophy in pepsinogen are risk factors for synchronous gastric cancers (SGCs). This study aimed to determine the association of alcohol drinking status or alcohol-related genetic polymorphism with SGCs and also stratify their risk. METHODS: This multi-center prospective cohort study included patients who underwent endoscopic submucosal dissection for the initial early gastric cancers at 22 institutions in Japan. We evaluated the association of alcohol drinking status or alcohol dehydrogenase 1B (ADH1B) and acetaldehyde dehydrogenase 2 (ALDH2) genotypes with SGCs. We then stratified the risk of SGCs by combining prespecified two factors and risk factors identified in this study. RESULTS: Among 802 patients, 130 had SGCs. Both the ADH1B Arg and ALDH2 Lys alleles demonstrated a significant association with SGCs on multivariate analysis (odds ratio, 1.77), although alcohol drinking status showed no association. The rates of SGCs in 0-3 risk factors in the combined evaluation of three risk factors (ever-smoking, severe gastric atrophy in pepsinogen, and both the ADH1B Arg and ALDH2 Lys alleles) were 7.6%, 15.0%, 22.0%, and 32.1%, respectively. The risk significantly increased from 0 to 3 risk factors on multivariate analysis (P for trend <0.001). CONCLUSIONS: Both the ADH1B Arg and ALDH2 Lys alleles were at high risk for SGCs. The risk stratification by these three factors may be a less invasive and promising tool for predicting their risk.
Is blue light imaging without magnification satisfactory as screening for esophageal squamous cell carcinoma? Post-hoc analysis of multicenter randomized controlled trial. 国際誌査読有り

Yohei Ogata, Waku Hatta, Tomoyuki Koike, So Takahashi, Tamotsu Matsuhashi, Wataru Iwai, Sho Asonuma, Hideki Okata, Motoki Ohyauchi, Hirotaka Ito, Yasuhiko Abe, Yu Sasaki, Masashi Kawamura, Masahiro Saito, Kaname Uno, Fumiyoshi Fujishima, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　2024年3月17日

DOI： 10.1111/den.14788 　

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OBJECTIVES: Narrow light observation is currently recommended as an alternative to Lugol chromoendoscopy (LCE) to detect esophageal squamous cell carcinoma (ESCC). Studies revealed little difference in sensitivity between the two modalities in expert settings; however, these included small numbers of cases. We aimed to determine whether blue light imaging (BLI) without magnification is satisfactory for preventing misses of ESCC. METHODS: This was a post-hoc analysis of a multicenter randomized controlled trial targeting patients at high risk of ESCC in expert settings. In this study, BLI without magnification followed by LCE was performed. The evaluation parameters included: (i) the diagnostic abilities of ESCC; (ii) the endoscopic characteristics of lesions with diagnostic differences between the two modalities; and (iii) the color difference between cancerous and noncancerous areas in BLI and LCE. RESULTS: This study identified ESCC in 49 of 699 cases. Of these cases, nine (18.4%) were missed by BLI but detected by LCE. In per-patient analysis, the sensitivity of BLI was lower than that of LCE following BLI (83.7% vs. 100.0%; P = 0.013), whereas the specificity and accuracy of BLI were higher (88.2% vs. 81.2%; P < 0.001 and 87.8% vs. 82.5%; P < 0.001, respectively). No significant endoscopic characteristics were identified, but the color difference was lower in BLI than in LCE (21.4 vs. 25.1; P = 0.003). CONCLUSION: LCE following BLI outperformed BLI in terms of sensitivity in patients with high-risk ESCC. Therefore, LCE, in addition to BLI, would still be required in screening esophagogastroduodenoscopy even by expert endoscopists.
Interactive training with a novel simulation model for upper gastrointestinal endoscopic hemostasis improves trainees’ technique and confidence 国際誌査読有り

Takeshi Kanno, Yutaro Arata, Eric Greenwald, Paul Moayyedi, Suguo Suzuki, Yutaka Hatayama, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Yutaka Kagaya, Tomoyuki Koike, Atsushi Masamune

Endoscopy International Open　12　(2)　E245-E252　2024年1月17日
出版者・発行元： Georg Thieme Verlag KG
DOI： 10.1055/a-2248-5110 　

ISSN：2364-3722

eISSN：2196-9736

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Background and study aims: Endoscopic hemostasis is a life-saving procedure for gastrointestinal bleeding; however, its training is often performed on real patients and during urgent situations that put patients at risk. Reports of simulation-based training models for endoscopic hemostasis are scarce. Herein, we developed a novel simulator called “Medical Rising STAR-Ulcer type” to practice endoscopic hemostasis with hemoclips and coagulation graspers. This study aimed to evaluate the reproducibility of the clinical difficulty of this model and the effectiveness of simulation-based training for clipping hemostasis.Patients and methods: This was a prospective educational study. Fifty gastroenterology resident doctors from Japan and Canada were recruited to participate in a simulation-based training program. The primary outcome was the success rate of clipping hemostasis. We measured differences in trainees’ subjective assessment scores and evaluated the co-occurrence network based on comments after training.Results: The hemostasis success rate of the trainees significantly increased after instruction (64% vs. 86%, p<0.05). The success rate for ulcers in the upper body of the stomach (59%), a high-difficulty site, was significantly lower than that for ulcers in the antrum, even after feedback and instruction. Trainees’ self-perceived proficiency and confidence significantly improved after simulation-based training (p<0.05). Co-occurrence network analysis showed that trainees valued a structured learning approach, acknowledged the simulator’s limitations, and recognized the need for continuous skill refinement. Conclusions: Our study demonstrates the potential of our simulation-based training model as a valuable tool for improving technical skills and confidence in trainees learning to perform endoscopic hemostasis.
A novel dry simulator model for learning comprehensive endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomy procedures while minimizing adverse bleeding events (with Video). 国際誌査読有り

Yutaka Hatayama, Takeshi Kanno, Tetsuya Takikawa, Ryotaro Matsumoto, Yutaro Arata, Suguo Suzuki, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Shin Miura, Waku Hatta, Shin Hamada, Kaname Uno, Kiyoshi Kume, Kazuhiro Kikuta, Naoki Asano, Akira Imatani, Tomoyuki Koike, Atsushi Masamune

Digestion　105　(2)　149-156　2024年1月10日

DOI： 10.1159/000536217 　

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BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincterotomy (EST) are essential skills for endoscopic cholangio-pancreatic procedures. However, these procedures have a high incidence of adverse events, and most training is currently patient-based. Herein, we aimed to develop an ERCP/EST simulator model to address the need for safer training alternatives, especially for learners with limited ERCP experience. METHODS: The model was designed to facilitate the use of actual endoscopic devices, supporting learning objectives that align with the components of the validated Bethesda ERCP Skill Assessment Tool (BESAT). BESAT focuses on skills such as papillary alignment and maintenance of duodenoscope position, gentle and efficient cannulation, controlled sphincterotomy in the correct trajectory, and guidewire manipulation. Thirty gastroenterology trainees used the simulator between May 2022 and March 2023, and their satisfaction was assessed using a visual analog scale (VAS) and pre- and post-training questionnaires. RESULTS: The novel simulator model comprises a disposable duodenal papillary portion, suitable for incision with an electrosurgical knife, alongside washable upper gastrointestinal tract and bile duct portions, designed for repeated use. The duodenal papillary portion enabled reproduction of a realistic endoscope position and the adverse bleeding events due to improper incisions. The bile duct portion allowed for the reproduction of fluoroscopic-like images, enabling learners to practice guidewire guidance and insert other devices. After training, the median VAS score reflecting the expectation for model learning significantly increased from 69.5 (interquartile range [IQR]:55.5-76.5) to 85.5 (IQR: 78.0-92.0) (P<0.01). All participants expressed their desire for repeated simulator training sessions. CONCLUSIONS: This innovative simulator serves as a practical educational tool, particularly beneficial for novices in ERCP. It facilitates hands-on practice with actual devices, enhancing procedural fluency and understanding of precise incisions to minimize the risk of bleeding complications during EST.
胃瘻抜去後の瘻孔閉鎖不全に対してOTSCが有用であった一例

小笠原光矢, 金笑奕, 小池智幸, 畑山裕, 尾形洋平, 齊藤真弘, 菅野武, 八田和久, 宇野要, 正宗淳

学会誌JSPEN　6　(Suppl.2)　494-495　2024年
出版者・発行元： (一社)日本栄養治療学会
eISSN：2434-4966
ピロリ菌総除菌時代における炎症性胃発癌への歯周病菌の関与招待有り査読有り

織内優好, 宇野要, 李秀載, 浅野直喜, 小池智幸, 正宗淳

日本ヘリコバクター学会誌　25　(2)　139-142　2024年1月
出版者・発行元： (一社)日本ヘリコバクター学会
ISSN：2187-8005
A case of refractory bleeding from duodenal angioectasia with acquired hemophilia A. 査読有り

Hiroko Abe, Masahiro Saito, Kaname Uno, Tomoyuki Koike, Satoshi Ichikawa, Masashi Saito, Takeshi Kanno, Waku Hatta, Naoki Asano, Atsushi Masamune

Clinical journal of gastroenterology　16　(3)　355-360　2023年6月

DOI： 10.1007/s12328-023-01790-1 　

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Acquired hemophilia A (AHA) is a coagulation disorder related to the factor VIII inhibitors, which might cause intractable bleeding of gastrointestinal tracts. However, its scarcity makes it difficult to recognize AHA as a pitfall of endoscopic hemostasis failure. An 81-year-old female with a history of endoscopic treatment for colon polyps visited a local hospital with chief compliments of bloody stool and severe anemia. During several examinations for the bleeding origin, esophagogastroduodenoscopy depicted a 5 mm-sized hemorrhagic angioectasia of the duodenum, followed by treatment with argon plasma coagulation. However, hemostasis was not achieved by multiple sessions of endoscopic hemostasis and transcatheter arterial embolization, so blood transfusion was repeatedly done and she was transferred to our hospital. Laboratory data showed severe anemia with coagulation disorder. Based on the results of von Willebrand factor activity, factor VIII activity and factor VIII inhibitor, we diagnosed AHA as a comorbidity. Endoscopic hemostasis was confirmed only after improvement of APTT level and negative for the factor VIII inhibitor by hemostatic bypass treatment with recombinant active factor VII and immunosuppressive therapy with prednisolone and cyclophosphamide. In case of refractory bleeding of gastrointestinal tract, we should suspect of a comorbidity of coagulation disorder like AHA.
Role of T-box transcription factor 3 in gastric cancers. 国際誌招待有り査読有り

Naoki Asano, Akira Imatani, Akio Takeuchi, Masashi Saito, Xiao-Yi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

World journal of gastrointestinal pathophysiology　14　(2)　12-20　2023年3月22日

DOI： 10.4291/wjgp.v14.i2.12 　

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The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.
Blue light imaging and linked color imaging as a screening mode for esophageal squamous cell carcinoma in high-risk patients: A multicenter randomized trial. 国際誌査読有り

Yohei Ogata, Waku Hatta, Tomoyuki Koike, So Takahashi, Tamotsu Matsuhashi, Tomoyuki Oikawa, Wataru Iwai, Sho Asonuma, Hideki Okata, Motoki Ohyauchi, Hirotaka Ito, Yasuhiko Abe, Yu Sasaki, Masashi Kawamura, Masahiro Saito, Kaname Uno, Fumiyoshi Fujishima, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　2023年2月18日

DOI： 10.1111/den.14538 　

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OBJECTIVES: Blue light imaging (BLI) and linked color imaging (LCI) are superior to conventional white light imaging for detecting esophageal squamous cell carcinoma (ESCC). Hence, we compared their diagnostic performances in ESCC screening. METHODS: This open-labeled, randomized controlled trial was performed at seven hospitals. Patients with a high risk of ESCC were randomly assigned to the BLI group (BLI followed by LCI) and LCI group (LCI followed by BLI). The primary endpoint was the detection rate of ESCC in the primary mode. The main secondary endpoint was its miss rate in the primary mode. RESULTS: In total, 699 patients were enrolled. The detection rate of ESCC did not significantly differ between the BLI and LCI groups [4.0% (14/351) vs. 4.9% (17/348); p = 0.565]; however, the number of patients with ESCC tended to be smaller in the BLI group (19 vs. 30). Notably, the miss rate of ESCC was lower in the BLI group [26.3% (5/19) vs. 63.3% (19/30); p = 0.012] and LCI detected no ESCCs missed by BLI. The sensitivity was higher in BLI (75.0% vs. 47.6%; p = 0.042); on the other hand, the positive predictive value in BLI tended to be lower (28.8% vs. 45.5%; p = 0.092). CONCLUSIONS: The detection rates of ESCC did not significantly differ between BLI and LCI. Although BLI may have a potential to be advantageous over LCI for the diagnosis of ESCC, it is still unclear whether BLI is superior to LCI, and a further large-scale study is needed.
Smoking history and severe atrophic gastritis assessed by pepsinogen are risk factors for the prevalence of synchronous gastric cancers in patients with gastric endoscopic submucosal dissection: a multicenter prospective cohort study. 査読有り

Waku Hatta, Tomoyuki Koike, Sho Asonuma, Hideki Okata, Kaname Uno, Tomoyuki Oikawa, Wataru Iwai, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Motoki Ohyauchi, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Kazuaki Norita, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

Journal of gastroenterology　58　(5)　433-443　2023年2月14日

DOI： 10.1007/s00535-023-01967-y 　

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BACKGROUND: No studies have evaluated the relationship between lifestyle and synchronous gastric cancers (SGCs) in patients with endoscopic submucosal dissection (ESD) for early gastric cancers (EGCs). Using data from the Tohoku gastrointestinal (GI) study, we aimed to identify factors associated with SGCs. METHODS: Tohoku GI study is a multicenter prospective cohort study investigating the relationship between lifestyle and metachronous gastric cancers. Patients who had a schedule to undergo ESD for primary EGCs were enrolled. We used logistic regression analysis to examine the relationship of 15 candidate factors, including lifestyle, with the prevalence of SGCs in this study. RESULTS: Of 850 patients between 2016 and 2019, 16.0% (136 patients) had SGCs. In multivariate analysis, smoking history (odds ratio [OR], 1.93; p = 0.048) and severe atrophic gastritis assessed by pepsinogen (OR, 1.92; p = 0.004) were risk factors for the prevalence of SGCs. Regarding smoking, current smoking (OR, 2.33; p = 0.021), but not former smoking (OR, 1.76; p = 0.098), was a significant risk factor for its prevalence. In the stratified analysis, severe atrophic gastritis assessed by pepsinogen was a risk factor in patients without Helicobacter pylori (H. pylori) eradication (OR, 2.10; p = 0.002), but not a risk factor in those with H. pylori eradication (OR, 0.75; p = 0.737). CONCLUSION: Smoking history was a risk factor for the prevalence of SGCs in patients with ESD for EGCs, and severe atrophic gastritis assessed by pepsinogen was also a risk factor when H. pylori was not eradicated.
早期胃癌治療後の早期・後期死亡関連因子

尾形洋平, 八田和久, 大原祐樹, 小池智幸, 阿部寛子, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 浅野直喜, 今谷晃, 山村明寛, 田中直樹, 亀井尚, 海野倫明, 中村智洋, 中谷直樹, 正宗淳

Gastroenterological Endoscopy　65　(2)　162,np1-np9　2023年2月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN：0387-1207

eISSN：1884-5738
Similar Effect of Vonoprazan and Oral Proton Pump Inhibitors for Preventing Rebleeding in Cases of Upper Gastrointestinal Bleeding 査読有り

Hiroko Abe, Kunio Tarasawa, Waku Hatta, Tomoyuki Koike, Isao Sato, Yoshitaka Ono, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

Internal Medicine　2023年
出版者・発行元： Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.2211-23 　

ISSN：0918-2918

eISSN：1349-7235
Discrepancy between Abdominal Symptoms and Endoscopic Findings in Patients with Gastro-duodenal Eosinophilia: A Case Series 査読有り

Hideyuki Sugawara, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Tomoyuki Koike, Atsushi Masamune

Internal Medicine　2023年
出版者・発行元： Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.1137-22 　

ISSN：0918-2918

eISSN：1349-7235
Wnt Signaling and Aging of the Gastrointestinal Tract 査読有り

Naoki Asano, Akio Takeuchi, Akira Imatani, Masashi Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

International Journal of Molecular Sciences　23　(20)　12210-12210　2022年10月13日
出版者・発行元： MDPI AG
DOI： 10.3390/ijms232012210 　

eISSN：1422-0067

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Aging is considered a risk factor for various diseases including cancers. In this aging society, there is an urgent need to clarify the molecular mechanisms involved in aging. Wnt signaling has been shown to play a crucial role in the maintenance and differentiation of tissue stem cells, and intensive studies have elucidated its pivotal role in the aging of neural and muscle stem cells. However, until recently, such studies on the gastrointestinal tract have been limited. In this review, we discuss recent advances in the study of the role of Wnt signaling in the aging of the gastrointestinal tract and aging-related carcinogenesis.
A Case of Duodenal Variceal Rupture during Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma. 査読有り

Mio Tsuruoka, Jun Inoue, Keishi Ouchi, Kaname Uno, Hideaki Itami, Masashi Ninomiya, Tomoaki Iwata, Akitoshi Sano, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Tomoyuki Koike, Atsushi Masamune

Internal medicine (Tokyo, Japan)　2022年10月5日

DOI： 10.2169/internalmedicine.0629-22 　

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Duodenal varices are detected infrequently, and their rupture is very rare. We encountered an 87-year-old man who developed duodenal varices rupture during chemotherapy with atezolizumab and bevacizumab (ATZ/BV) for hepatocellular carcinoma. We identified massive bleeding of a ruptured varix in the horizontal portion of the duodenum with emergency esophagogastroduodenoscopy (EGD). Successful hemostasis was achieved by endoscopic injection sclerotherapy with Histoacryl. Although ATZ/BV can cause esophageal varices rupture, there have been no cases of duodenal varices rupture. We should take care to check the duodenal varices as well as esophagogastric varices before ATZ/BV treatment.
A case of refractory esophageal stricture due to occult gastrinoma of the duodenum. 査読有り

Keisuke Kusano, Kaname Uno, Tomoyuki Koike, Shin Miura, Kiyoshi Kume, Masato Nakahori, Fumiyoshi Fujishima, Hideo Ohtsuka, Michiaki Unno, Atsushi Masamune

Clinical journal of gastroenterology　15　(5)　859-863　2022年10月

DOI： 10.1007/s12328-022-01657-x 　

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Gastrinoma may cause refractory esophageal stricture due to gastro-esophageal reflux disease (GERD), but imaging technologies have limited power in its diagnosis. A 74-year-old female with a history of peptic ulcers suffered from repeated epigastralgia, and she visited a local hospital. An esophago-gastro-duodenoscopy (EGD) demonstrated severe reflux esophagitis and multiple peptic ulcers. Blood examination revealed a high value of fasting serum gastrin. Multi-detector computed tomography showed a hypervascular and tiny nodule in duodenal bulb, although other imaging technologies did not. Short-term medication with a proton pump inhibitor or potassium-competitive acid blocker was intermittently provided, but dysphagia was repeatedly worsened, and she was referred to our division. Serum hypergastrinemia was retained, and EGD reexamination depicted esophageal stricture, treated by multiple sessions of endoscopic balloon dilatation. Primary tumor was not identified by the morphological imaging technologies, but a selective arterial secretagogue injection test suggested its existence in the duodenum or pancreatic head. Pancreaticoduodenectomy was performed, and histological study identified 2 mm-sized microgastrinoma buried in Brunner`s glands on the posterior wall of the duodenum bulb. We reported a case with difficulty in diagnosis of the smallest sporadic gastrinoma of the duodenum, which might cause refractory GERD-associated stricture.
Management of Superficial Esophageal Squamous Cell Carcinoma and Early Gastric Cancer following Non-Curative Endoscopic Resection. 国際誌招待有り査読有り

Waku Hatta, Tomoyuki Koike, Kaname Uno, Naoki Asano, Atsushi Masamune

Cancers　14　(15)　2022年8月2日

DOI： 10.3390/cancers14153757 　

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According to the European and Japanese guidelines, additional treatment is recommended for cases of superficial esophageal squamous cell carcinoma (ESCC) and early gastric cancer (EGC) that do not meet the curability criteria for endoscopic resection (ER), i.e., non-curative ER, owing to the risk of lymph node metastasis (LNM). However, the rates of LNM in such cases were relatively low (e.g., 8% for EGC). Several recent advances have been made in this field. First, pathological risk stratification for metastatic recurrence following non-curative ER without additional treatment was developed for both superficial ESCC and EGC. Second, the pattern of metastatic recurrence and prognosis after recurrence following non-curative ER without additional treatment was found to be considerably different between superficial ESCC and EGC. Third, a combination of ER and selective chemoradiotherapy was developed as a minimally invasive treatment method for clinical T1b-SM ESCC. These findings may help clinicians decide the treatment strategy for patients following non-curative ER; however, for optimal therapeutic decision-making in such patients, it is also important to predict the prognosis other than SESCC or EGC and impaired quality of life. Thus, a novel algorithm that considers these factors, as well as metastatic recurrence, should be developed.
Suppressed cellular senescence mediated by T-box3 in aged gastric epithelial cells may contribute to aging-related carcinogenesis 査読有り

Akio Takeuchi, Naoki Asano, Akira Imatani, Masashi Saito, Xiaoyi Jin, Masahiro Saito, Takeshi Kanno, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

Cancer Research Communications　2022年7月14日
出版者・発行元： American Association for Cancer Research (AACR)
DOI： 10.1158/2767-9764.crc-22-0084 　

eISSN：2767-9764

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Abstract Aging is a risk factor for cancers in various organs. Recent advances in the organoid culturing system have made it viable to investigate the influence of aging utilizing these mini organs. In this study, we aimed to examine the implications of aging for gastric carcinogenesis. Gastric organoids established from aged mice grew larger, proliferated vigorously, and survived longer than that from young mice. Since Wnt/b-catenin signaling was intensified in the aged organoids and since removal of Wnt-related factors diminished their proliferation, we investigated for Wnt target gene that contributed to enhanced proliferation and discovered that the aged organoids expressed the transcription factor T-box3 (Tbx3), which has been reported to suppress cellular senescence. Indeed, cellular senescence was suppressed in the aged organoids, and this resulted from enhanced G2/M transition. As for the mechanism involved in the intensified Wnt/b-catenin signaling, we identified that Dickkopf3 (Dkk3) expression was reduced in the aged organoids due to methylation of the Dkk3 gene. Finally, the expression of TBX3 was enhanced in human atrophic gastritis and even more enhanced in human gastric cancers. In addition, its expression correlated positively with patients' age. These results indicated that the emergence of anti-senescent property in aged gastric organoids due to enhanced Tbx3 expression led to accelerated cellular proliferation and organoid formation. Since the enhanced Tbx3 expression seen in aged gastric organoids was also observed in human gastric cancer tissues, this Dkk3-Wnt-Tbx3 pathway may be involved in aging-related gastric carcinogenesis.
A Case of Gastric Cancer With a Rare Spreading Pattern Into the Submucosal Layer 査読有り

Yutaka Hatayama, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Tomoyuki Koike, Atsushi Masamune

Journal of the Canadian Association of Gastroenterology　2022年4月8日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/jcag/gwac012 　

ISSN：2515-2084

eISSN：2515-2092
Recent approach for preventing complications in upper gastrointestinal endoscopic submucosal dissection 招待有り査読有り

Waku Hatta, Tomoyuki Koike, Hiroko Abe, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

DEN Open　2　(1)　2022年4月
出版者・発行元： Wiley
DOI： 10.1002/deo2.60 　

ISSN：2692-4609

eISSN：2692-4609
Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia. 査読有り

Yasuaki Abe, Waku Hatta, Sho Asonuma, Tomoyuki Koike, Hiroko Abe, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Hironobu Sasano, Atsushi Masamune

Internal medicine (Tokyo, Japan)　2022年2月1日

DOI： 10.2169/internalmedicine.8253-21 　

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A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase [please check this carefully]. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up.
Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma 査読有り

Shusuke Toda, Waku Hatta, Kiyotaka Asanuma, Naoki Asano, Yoshitaka Ono, Hiroko Abe, Yohei Ogata, Masahiro Saito, Takeshi Kanno, Xiaoyi Jin, Kaname Uno, Tomoyuki Koike, Akira Imatani, Shin Hamada, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

The Tohoku Journal of Experimental Medicine　2022年
出版者・発行元： Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j077 　

ISSN：0040-8727

eISSN：1349-3329
Is Additional Gastrectomy Required for Elderly Patients after Endoscopic Submucosal Dissection with Endoscopic Curability C-2 for Early Gastric Cancer? 国際誌査読有り

Waku Hatta, Takuji Gotoda, Tomoyuki Koike, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

Digestion　103　(1)　83-91　2022年

DOI： 10.1159/000519514 　

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BACKGROUND: With the ongoing growth of the aged population, the number of elderly patients suffering from gastric cancer has increased in Japan. Since the frequency of lymph node metastasis (LNM) in patients after endoscopic submucosal dissection (ESD) with endoscopic curability (eCura) C-2 for early gastric cancer (EGC) is relative low, the following question can be raised: "Is additional gastrectomy required for elderly patients with such criteria for ESD?" SUMMARY: For therapeutic decision-making after ESD with eCura C-2, the risk of all-cause mortality and impaired quality of life (QoL) should thus be evaluated. Risk stratification of LNM and gastric cancer-specific mortality was established by the eCura system; however, it remains unclear how much these categories and treatment selection affect all-cause mortality. The contribution of prognostic tools for predicting all-cause mortality was noted to vary across the studies of patients with EGC; thus, further studies that investigate comprehensive geriatric assessment (CGA) may be required. Regarding the QoL, studies on elderly patients remain to be lacking. Furthermore, one of the issues with CGA and QoL tools is that they are time consuming. Key Messages: Combined evaluation of risk stratification of gastric cancer-specific mortality by the eCura system and risk of nongastric cancer-related mortality and impaired QoL may be the current optimal method to decide treatment strategy after ESD with eCura C-2 for EGC among elderly patients. A large-scale prospective study that investigates CGA domains is required to identify predictors of all-cause mortality and impaired QoL, and a more easily usable tool should be developed.
Reply to "Acid suppressants during hospitalization and after discharge in patients after gastroduodenal ESD". 招待有り査読有り

Hiroko Abe, Kunio Tarasawa, Waku Hatta, Kaname Uno, Tomoyuki Koike, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

Journal of gastroenterology　56　(12)　1109-1110　2021年12月

DOI： 10.1007/s00535-021-01824-w 　
Comparison of Magnifying Endoscopy with Blue Light Imaging and Narrow Band Imaging for Determining the Invasion Depth of Superficial Esophageal Squamous Cell Carcinoma by the Japanese Esophageal Society's Intrapapillary Capillary Loop Classification. 国際誌査読有り

Waku Hatta, Tomoyuki Koike, Yohei Ogata, Yutaka Kondo, Nobuyuki Ara, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

Diagnostics (Basel, Switzerland)　11　(11)　2021年10月20日

DOI： 10.3390/diagnostics11111941 　

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Blue light imaging (BLI) and narrow-band imaging (NBI) are two modalities that enable narrow-band light observation. We aimed to compare the diagnostic ability of magnifying endoscopy with BLI (ME-BLI) and NBI (ME-NBI) for determining the invasion depth of superficial esophageal squamous cell carcinoma (SESCC) by the Japanese Esophageal Society's intrapapillary capillary loop (IPCL) classification. We enrolled 81 patients between 2014 and 2018, and the still endoscopic images for diagnosing the invasion depth at the same part in ME-BLI and ME-NBI were registered. Two blinded investigators reviewed them and diagnosed the invasion depth by the IPCL classification. Subsequently, the diagnostic yields in two modalities were compared. The overall accuracies for the invasion depth by the IPCL classification in ME-BLI and ME-NBI did not differ significantly (67.9-71.6% vs. 72.8-74.1%). In the analysis based on the invasion depth, the sensitivities and positive predictive values in tumors invading the muscularis mucosa or submucosa ≤200 µm were low (23.1-30.8% and 16.7-25.0%, respectively) in both modalities. In conclusion, the diagnostic ability for determining the invasion depth of SESCC by the IPCL classification was relatively similar in ME-BLI and ME-NBI, but diagnosis by magnifying endoscopy alone might not be satisfactory.
Predictors of early and late mortality after the treatment for early gastric cancers. 国際誌査読有り

Yohei Ogata, Waku Hatta, Yuki Ohara, Tomoyuki Koike, Hiroko Abe, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Akihiro Yamamura, Naoki Tanaka, Takashi Kamei, Michiaki Unno, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　2021年10月18日

DOI： 10.1111/den.14172 　

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OBJECTIVES: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately. METHODS: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of 3 years. RESULTS: We enrolled 1439 patients with a median follow-up period of 79 months. The 5-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥85 years (hazard ratio [HR] 2.88 and 4.54, respectively) and Eastern Cooperative Oncology Group Performance Status ≥2 (HR 3.00 and 4.19, respectively). Charlson comorbidity index ≥2 (HR 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥3 (HR 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥0.028 (HR 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR 2.26), intermediate- (HR 2.12)/high-risk (HR 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR 1.70) were predictors for early mortality. CONCLUSION: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality.
A rare case of penetration related to ischemic duodenitis after ventricular assist device implantation for dilated cardiomyopathy. 査読有り

Hiroko Abe, Kaname Uno, Naoki Tanaka, Masamichi Mizuma, Waku Hatta, Naoki Asano, Tomoyuki Koike, Akira Imatani, Michiaki Unno, Atsushi Masamune

Clinical journal of gastroenterology　14　(4)　1186-1190　2021年8月

DOI： 10.1007/s12328-021-01346-1 　

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A 66-year-old man with a history of diabetes and dilated cardiomyopathy underwent the implantation of a ventricular assist device (VAD) at the age of 62. He suffered from epigastralgia for a month and then visited our hospital with complaints of severe epigastralgia and hematemesis. A physical examination revealed abdominal distension without rigidity. Laboratory data showed severe systemic inflammation, multiple organ failure, and disseminated intravascular coagulation. Computed tomography showed multifocal thickness of the gastroduodenal wall with surrounding panniculitis, gas in a portal vein and a perigastric vein. Emergency esophago-gastro duodenoscopy (EGD) demonstrated a large erosion in the antrum of the stomach, and penetration surrounded by circumferentially ischemic mucosa in the second and third portions of the duodenum. Based on informed consent, conservative therapy was performed, and his condition improved enabling the start of oral intake on the 37th hospital day. However, 7 days later, there was a relapse of epigastralgia after a meal. Gastrointestinal series and EGD revealed a 10-mm-long pinhole-like stricture at the site. After laparoscopic gastro-jejunal bypass surgery, he has remained in a good condition for 2 years. We demonstrated a rare case of penetration due to severe ischemic duodenitis 4 years after VAD implantation.
Prevention of delayed bleeding with vonoprazan in upper gastrointestinal endoscopic treatment. 査読有り

Hiroko Abe, Waku Hatta, Yohei Ogata, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Kunio Tarasawa, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

Journal of gastroenterology　56　(7)　640-650　2021年7月

DOI： 10.1007/s00535-021-01781-4 　

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BACKGROUND: Delayed bleeding is the major adverse event in upper gastrointestinal endoscopic treatment (UGET). We aimed to investigate the efficacy of vonoprazan, which is the novel strong antisecretory agent, to reduce the risk for delayed bleeding in comparison with proton pump inhibitors (PPIs) in UGET. METHODS: This retrospective population-based cohort study used the Diagnosis Procedure Combination database in Japan. We included patients on vonoprazan or PPI in UGET between 2014 and 2019. The primary outcome was delayed bleeding. We conducted propensity score matching to balance the comparison groups, and logistic regression analyses to compare the bleeding outcomes. RESULTS: We enrolled 124,422 patients, in which 34,822 and 89,600 were prescribed with vonoprazan and PPI, respectively. After propensity score matching, the risk for delayed bleeding was lower in vonoprazan than in PPI (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.71-0.80), consistent with sensitivity analysis results. In the subgroup analyses of seven UGET procedures, vonoprazan was significantly advantageous in esophageal endoscopic submucosal dissection (E-ESD) (OR, 0.71; 95% CI, 0.54-0.94) and gastroduodenal endoscopic submucosal dissection (GD-ESD) (OR, 0.70; 95% CI, 0.65-0.75), although correction for multiple testing of the outcome data removed the significance in E-ESD. These results were also consistent with sensitivity analysis results. In the five other procedures, no significant advantage was found. CONCLUSIONS: This nationwide study found that, compared with PPI, vonoprazan can reduce delayed bleeding with approximately 30% in GD-ESD. Vonoprazan has the possibility to become a new treatment method for preventing delayed bleeding in this procedure.
A Rare Case of Localized Esophageal Amyloidosis. 査読有り

Taku Fujiya, Waku Hatta, Tomoyuki Koike, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Nagaaki Katoh, Tsuneaki Yoshinaga, Atsushi Masamune

Internal medicine (Tokyo, Japan)　60　(10)　1529-1532　2021年5月15日

DOI： 10.2169/internalmedicine.6321-20 　

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A 72-year-old man without any symptoms was referred to our hospital. Esophagogastroduodenoscopy revealed an elevated esophageal lesion that was covered with normal mucosa. The examination of biopsy specimens from the lesion revealed amyloid light-chain (AL) (λ) type amyloid deposits, but there were no amyloid deposits elsewhere in the gastrointestinal tract. Further examinations did not indicate systemic amyloidosis. Thus, this case was diagnosed as a localized esophageal amyloidosis. As the clinical outcome of localized amyloidosis is favorable, this case was scheduled for close follow-up. Localized amyloidosis should be considered in the differential diagnosis of esophageal submucosal tumors.
新規内視鏡シミュレーターを用いた、消化管止血術学習プログラムによる教育介入研究

畑山裕, 菅野武, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A329-A329　2021年3月
出版者・発行元： (一財)日本消化器病学会
ISSN：0446-6586

eISSN：1349-7693
歯周病菌リポ多糖類刺激によるピロリ菌除菌療法後の胃粘膜バリア傷害の検討

織内優好, 宇野要, 李秀載, 齊藤真弘, 中川健一郎, 金笑奕, 菅野武, 八田和久, 浅野直喜, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A332-A332　2021年3月
出版者・発行元： (一財)日本消化器病学会
ISSN：0446-6586

eISSN：1349-7693
新規内視鏡シミュレーターを用いた、消化管止血術学習プログラムによる教育介入研究

畑山裕, 菅野武, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A329-A329　2021年3月
出版者・発行元： (一財)日本消化器病学会
ISSN：0446-6586

eISSN：1349-7693
【Barrett食道腺癌の内視鏡診断と治療2021】Barrett食道腺癌のsurveillance LSBEを中心に

小池智幸, 齊藤真弘, 大原祐樹, 伊丹英昭, 外田修裕, 竹内章夫, 大方智樹, 李秀載, 中川健一郎, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

胃と腸　56　(2)　163-173　2021年2月
出版者・発行元： (株)医学書院
ISSN：0536-2180

eISSN：1882-1219
Linked-color Imaging May Help Improve the Visibility of Superficial Barrett's Esophageal Adenocarcinoma by Increasing the Color Difference. 査読有り

Masahiro Saito, Tomoyuki Koike, Yuki Ohara, Kenichiro Nakagawa, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

Internal medicine (Tokyo, Japan)　60　(21)　3351-3358　2021年

DOI： 10.2169/internalmedicine.6674-20 　

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Objective Linked-color imaging (LCI), a new technology for image-enhanced endoscopy, emphasizes the color of the mucosa, and its practicality in the detection of early gastric and colon cancers has been reported. However, whether or not LCI is useful for the diagnosis of Barrett's adenocarcinoma (BA) has been unclear. In this study, we explored whether or not LCI enhances the color difference between a BA lesion and the surrounding mucosa. Methods Twenty-one lesions from 20 consecutive patients with superficial BA who underwent endoscopic submucosal dissection between November 2014 and September 2017 were retrospectively examined. The color differences (ΔE*) between the inside and outside of the lesion were evaluated retrospectively using white-light imaging (WLI), blue-light imaging (BLI), and LCI objectively, based on a Commission Internationale de l'Eclairage (CIE) lab color system. Furthermore, we compared the morphology, color, and circumferential location of the lesion. Results The median values of the color difference (ΔE*) in WLI and BLI were 9.1 and 5.8, respectively, and no difference was observed. In LCI, the median color difference was 17.6, which was higher than that of WLI and BLI. Regardless of the morphology, color, and circumferential location of BA lesions, the color difference was larger in LCI than in WLI. Conclusion LCI increases the color difference between the BA and the surrounding Barrett's mucosa.
The Ameliorating Effect of Switching to Vonoprazan: A Novel Potassium-Competitive Acid Blocker in Patients with Proton Pump Inhibitor Refractory Non-Erosive Reflux Disease. 国際誌査読有り

Yasuaki Abe, Tomoyuki Koike, Masahiro Saito, Tomoki Okata, Kenichiro Nakagawa, Waku Hatta, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

Digestion　102　(3)　480-488　2021年

DOI： 10.1159/000506152 　

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INTRODUCTION: Weakly acidic reflux has been reported to be the major cause of symptoms in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) undergoing PPI treatment. We previously reported that reflux at pH 4-5 was the main factor that induced symptoms in such patients. The present study aimed to elucidate the symptom-ameliorating effect of vonoprazan (VPZ) by evaluating the change in the pH value of the refluxate using multichannel intraluminal impedance and pH (MII-pH) monitoring. METHODS: We retrospectively evaluated the records of MII-pH monitoring in 29 symptom index (SI) and/or symptom association probability (SAP)-positive patients with PPI-refractory NERD. After switching to VPZ 20 mg/day, we performed MII-pH monitoring again. We assessed the change in the score of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), the pH value of the refluxate, and the percent times of intragastric pH <4 or <5 before and after switching. We divided the patients into the following 2 groups according to the FSSG score after switching: effective and noneffective groups. RESULTS: Among of the 29 SI/SAP-positive patients, 16 underwent switching to VPZ. Furthermore, of these 16 patients, 10 underwent MII-pH monitoring again after switching. The FSSG score decreased, the pH value of the refluxate increased, and the percent times of intragastric pH <4 or <5 reduced after switching when compared with the findings before switching. In the effective group, both the proportion of reflux at pH <4 and that of reflux at pH 4-5 decreased while taking VPZ when compared with the findings while taking double-dose PPI. In the noneffective group, the proportion of reflux at pH <4 decreased but that of reflux at pH 4-5 increased and that of reflux at pH <5 did not change overall while taking VPZ. In addition, the percent times of intragastric pH <5 values were low in the effective group. CONCLUSION: Symptom suppression appears to be inadequate in patients with persistent reflux at pH 4-5 even with VPZ 20 mg/day. Strong acid suppressive therapy with VPZ to increase the pH value of the refluxate to ≥5 is useful for symptom improvement.
Predictors of Early and Late Mortality after Endoscopic Resection for Esophageal Squamous Cell Carcinoma. 査読有り

Yohei Ogata, Waku Hatta, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

The Tohoku journal of experimental medicine　253　(1)　29-39　2021年1月

DOI： 10.1620/tjem.253.29 　

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In esophageal squamous cell carcinoma (ESCC) comprising 90% of cases with esophageal cancer, endoscopic resection (ER) is recommended for patients with negligible risk of ESCC-related mortality. In fact, a main cause of death in patients underwent ER is not ESCC. We thus aimed to clarify the predictors for early and late mortality among patients underwent ER of ESCC between 2005 and 2018 at our institution. In this retrospective cohort study, we investigated the prognosis and predictors of early and late mortality with the cut-off value of 3 years. We enrolled 407 patients with a median 69 months follow-up. The 5-year overall survival and disease-specific survival, an indicator of ESCC-related mortality, were 83.4% and 98.4%, respectively. In multivariate Cox analyses, Eastern Cooperative Oncology Group performance status (ECOG-PS), consisting of six grades by a patient's level of activity, ≥ 2 was a predictor for early and late morality [hazard ratio (HR), 7.21 (P = 0.007) and 15.62 (P = 0.021), respectively]. Charlson comorbidity index (CCI), which is an index for predicting mortality by comorbid conditions, ≥ 2 was also a predictor for both mortality [HR, 2.97 (P = 0.017) and 1.90 (P = 0.019), respectively]. However, age was a predictor only for late mortality [HR, 3.08 (P = 0.010) in 80-84 years and 8.38 (P < 0.001) in ≥ 85 years]. Considering the predictive ability for early mortality, we propose that ECOG-PS and/or CCI are better indices compared with age in deciding treatment strategy after ER for ESCC.
A Case of the Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis 査読有り

Masahiro Saito, Tomoyuki Koike, Yasuaki Abe, Kenichiro Nakagawa, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Atsushi Masamune

Internal Medicine　2021年
出版者・発行元： Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.5431-20 　

ISSN：0918-2918

eISSN：1349-7235
Localized Gastric Amyloidosis that Displayed Morphological Changes over 10 Years of Observation 査読有り

Yasushi Takahashi, Waku Hatta, Tomoyuki Koike, Yohei Ogata, Taku Fujiya, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Nagaaki Katoh, Tsuneaki Yoshinaga, Atsushi Masamune

Internal Medicine　2021年
出版者・発行元： Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.5031-20 　

ISSN：0918-2918

eISSN：1349-7235
A rare case of gastric squamous-cell carcinoma metastasized from the cervix. 査読有り

Masayoshi Oriuchi, Kaname Uno, Fumiyoshi Fujishima, Akio Takeuchi, Sujae Lee, Waku Hatta, Naoki Asano, Tomoyuki Koike, Akira Imatani, Atushi Masamune

Clinical journal of gastroenterology　13　(6)　1062-1065　2020年12月

DOI： 10.1007/s12328-020-01191-8 　

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Gastric squamous-cell carcinoma (SqCC) metastasized form the cervix is rarely detected in endoscopic examination, although cervical carcinoma is the second most common in gynecologic malignancy. A 59-year-old female visited a clinic for anorexia, and an esophago-gastro-duodenoscopy (EGD) revealed multiple submucosal tumors (SMTs) of the stomach. After she was referred, an image-enhanced endoscopy enhanced multiple SMTs with white spots, whose findings were irregular micro-vascular patterns in the mucosa with irregular/absent micro-surface pattern. We took endoscopic biopsies, whose histological diagnoses were SqCC in the layer of the lamina propria under normal epithelium. Positron emission tomography-CT, CT and magnetic resonance imaging revealed an irregularly enhanced mass of the cervix, the irregularly thickening wall of the stomach and peritoneal nodules. Palliative care alone was administered based on poor condition associated with the Stage IV cervical carcinoma. In this case, endoscopic detection of gastric SqCC might provide a tip to make final diagnosis of primary site of cervical SqCC. The numbers of endoscopic examination become increasing, so further deep awareness of such patterns of metastasis in cervical cancer are required.
Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease. 国際誌査読有り

Kazuaki Norita, Kiyotaka Asanuma, Tomoyuki Koike, Tomoki Okata, Taku Fujiya, Yasuaki Abe, Kenichiro Nakagawa, Waku Hatta, Kaname Uno, Tomohiro Nakamura, Naoki Nakaya, Naoki Asano, Akira Imatani, Tooru Shimosegawa, Atsushi Masamune

Digestion　1-11　2020年8月12日

DOI： 10.1159/000508661 　

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BACKGROUND AND OBJECTIVE: Weakly acidic reflux reaching to the proximal esophagus is closely related to the perception of gastroesophageal reflux in patients with nonerosive reflux disease despite treatment with a proton pump inhibitor (PPI). However, little is known about the involvement of the patients' mucosal integrity of the proximal esophagus. METHODS: We recruited 15 symptomatic nonerosive gastroesophageal reflux disease (GERD) patients with a positive symptom index despite PPI treatment and 11 healthy asymptomatic volunteers as controls. The biopsy specimens obtained from the proximal and distal esophagus were applied to a mini-Ussing chamber system to measure transepithelial electrical resistance (TEER) against a pH 4 weak acid. The esophageal biopsy samples were subjected to quantitative real-time PCR and immunohistochemical analysis. RESULTS: In the proximal esophagus, the weak acid exposure reduced the TEER in the PPI-refractory patients compared to that in the controls. The frequency of the reflux extending to the proximal esophagus had a significant correlation with the reduction in the proximal esophageal TEER in the patients. The reduced TEER in the proximal esophagus was accompanied by an increase in IL-8 and IL-1β mRNA and a decrease in occludin mRNA levels. The proximal esophageal mucosa in the patients presented infiltration of CD3-positive lymphocytes and an increased expression of solute carrier organic anion transporter family member 2A1 (SLCO2A1), a passage gate of reflux symptom-evoking molecules. CONCLUSIONS: The reflux perception is related to an impairment of the proximal esophageal mucosal integrity in patients with nonerosive reflux disease despite PPI.
Sox2 induces tumorigenesis and angiogenesis of early stage esophagealsquamous cell carcinoma through secretion of Suprabasin. 国際誌査読有り

Kiichi Takahashi, Naoki Asano, Akira Imatani, Yutaka Kondo, Masashi Saito, Akio Takeuchi, Xiaoyi Jin, Masahiro Saito, Waku Hatta, Kiyotaka Asanuma, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

Carcinogenesis　2020年2月14日

DOI： 10.1093/carcin/bgaa014 　

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Early stage of esophageal squamous cell carcinoma (ESCC) is known to be accompanied by angiogenesis and morphological changes of microvessels. Transcription factor Sox2 is amplified in various cancers including ESCC, but the role of Sox2 in the carcinogenesis and angiogenesis has not been determined. Hence, we aimed to investigate the role of Sox2 in the early stage of ESCC. We found that the expression of Sox2 was significantly higher in early stage ESCC tissues than that in their adjacent normal tissues. We then established Sox2-inducible normal human esophageal squamous cell line (HetSox2) to investigate the role of Sox2 in esophageal carcinogenesis and angiogenesis in vitro. Sox2 overexpression led to increased cell proliferation and spheroid formation. The culture supernatant of Sox2-overexpressing HetSox2 induced migration and sprouting of endothelial cell line HUVEC. As for the mechanism, we found that the expression of secreted protein Suprabasin was directly induced by Sox2. Suprabasin enhanced proliferation of normal human esophageal squamous cells and HUVEC when added to the culture. Moreover, Suprabasin enhanced migration and sprouting of HUVEC cells, which were observed with the culture supernatant of Sox2-oversxpressing HetSox2. This angiogenic effect of Suprabasin was abolished by inhibiting AKT phosphorylation, which suggested its dependence on AKT signaling. Finally, we showed that Suprabasin expression and the density of microvessels were significantly higher in ESCC tissues with high Sox2 expression. Our study suggested that increased Sox2 expression in esophageal squamous cells induced Suprabasin expression, and as a result initiated the carcinogenesis via increased cell proliferation and angiogenesis.
Gastric Duplication Cyst With Occult GIST Component. 国際誌査読有り

Sujae Lee, Kaname Uno, Fumiyoshi Fujishima, Waku Hatta, Tomoyuki Koike, Takeshi Aoki, Naoki Tanaka, Hiroaki Musha, Ryosuke Kikuchi, Atsushi Masamune

ACG case reports journal　7　(2)　e00260　2020年2月

DOI： 10.14309/crj.0000000000000260 　

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A 37-year-old man underwent screening examinations, and a pale-colored submucosal tumor was detected on gastric cardia. Endosonography showed a 15-mm cyst with hypoechoic nodules in the muscularis propria, and endoscopic ultrasound-guided fine-needle aspiration obtained mucinous fluid with atypical spindle cells positive for c-kit, indicating a gastrointestinal stromal tumor. Surgical resection was recommended, but he initially agreed to surveillance. After becoming larger for 8 years, partial gastrectomy was performed for the 22 × 22 × 15-mm capsulized lesion. Surprisingly, its histology was gastric duplication cyst without gastrointestinal stromal tumor. Gastric duplication cyst is a rare entity with the possibility of malignant complications, but careful assessment of endoscopic ultrasound-guided fine-needle aspiration might also be required.
A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component. 査読有り

Takeuchi A, Hatta W, Koike T, Saito M, Jin X, Asanuma K, Uno K, Asano N, Imatani A, Fujishima F, Masamune A

Internal medicine (Tokyo, Japan)　58　(17)　2467-2472　2019年9月

DOI： 10.2169/internalmedicine.2722-19 　

ISSN：0918-2918
Difficult Preoperative Diagnosis of Lymphoepithelioma-Like Carcinoma of the Esophagus. 査読有り

Okata T, Uno K, Fujishima F, Saito M, Jin X, Hatta W, Asanuma K, Asano N, Koike T, Imatani A, Masamune A

ACG Case Rep J　2019年8月
Strong Intra-Esophageal Reflux May Contribute to the Development of Barrett's Adenocarcinoma and Affect the Localization. 査読有り

Saito M, Koike T, Nakagawa K, Abe Y, Norita K, Kikuchi H, Kanno T, Hatta W, Ara N, Uno K, Asanuma K, Asano N, Imatani A, Shimosegawa T, Masamune A

Digestion　1-9　2019年8月

DOI： 10.1159/000502377 　

ISSN：0012-2823
Influence of the pH Value of Refluxate and Proximal Extent on Heartburn Perception in Patients with Proton Pump Inhibitor-Refractory Non-Erosive Reflux Disease. 査読有り

Abe Y, Koike T, Saito M, Okata T, Norita K, Kikuchi H, Nakagawa K, Hatta W, Asanuma K, Uno K, Asano N, Imatani A, Shimosegawa T, Masamune A

Digestion　1-7　2019年7月

DOI： 10.1159/000500133 　

ISSN：0012-2823
Continuously liquid-sucking catheter attachment for the endoscope reduces the volume of liquid reflux to the mouth in esophageal endoscopic submucosal dissection. 査読有り

Hatta W, Koike T, Okata H, Hanzawa T, Saito M, Kondo Y, Ara N, Asanuma K, Uno K, Asano N, Imatani A, Iijima K, Nakamura T, Nakaya N, Masamune A

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　2019年3月

DOI： 10.1111/den.13392 　

ISSN：0915-5635
Endoscopic Findings of Esophageal Adenosquamous Carcinoma Diagnosed by Endoscopic Mucosal Resection. 査読有り

Endo H, Koike T, Hatta W, Asanuma K, Uno K, Asano N, Imatani A, Watanabe M, Kato K, Masamune A

Case reports in gastroenterology　13　(1)　144-152　2019年1月

DOI： 10.1159/000499182 　
Management of aorto-esophageal fistula secondary after thoracic endovascular aortic repair: a review of literature 査読有り

Kaname Uno, Tomoyuki Koike, Seiichi Takahashi, Daisuke Komazawa, Tooru Shimosegawa

Clinical Journal of Gastroenterology　10　(5)　393-402　2017年10月1日
出版者・発行元： Springer Tokyo
DOI： 10.1007/s12328-017-0762-z 　

ISSN：1865-7265 1865-7257
Risk of metachronous recurrence after endoscopic submucosal dissection of esophageal squamous cell carcinoma 査読有り

K. Uno, T. Koike, G. Kusaka, Y. Takahashi, N. Ara, T. Shimosegawa

DISEASES OF THE ESOPHAGUS　30　(6)　2017年6月

DOI： 10.1093/dote/dox005 　

ISSN：1442-2050
胃酸分泌能の内視鏡診断査読有り

八田和久, 下瀬川徹, 飯島克則, 小池智幸, 近藤穣, 荒誠之, 浅沼清孝, 宇野要, 浅野直喜, 今谷晃

日本消化器内視鏡学会雑誌　58　(10)　2222-2231　2016年10月
出版者・発行元：一般社団法人日本消化器内視鏡学会
ISSN：0387-1207

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背景と目的：胃酸分泌異常は，Helicobacter pylori（H. pylori）感染に伴う様々な疾患に関連する．だが，多くの微小内視鏡所見と酸分泌能の関連性を同時に調べた研究は，これまでに報告されていない．そこで，本研究では，高酸と低酸の診断に有用な微小内視鏡所見を明らかにすることを目的とした．方法：1999年から2012年の間，当院にて上部消化管内視鏡とガストリン刺激にて胃酸分泌能を評価するEndoscopic gastrin test（EGT）を行った器質的疾患のない223例を対象とし，後方視的に解析した．２名の対象者情報を知らない内視鏡専門医がそれぞれ別個に内視鏡画像を見直し，内視鏡所見を記録した．結果：EGT値より，対象者を高酸群，正酸群，低酸群の３群に分類した．全対象者での検討では，ヘマチン（オッズ比［95％信頼区間］＝3.32［1.40-7.83］），前庭部びらん（2.88［1.26-6.70］）が高酸を有意に示唆する内視鏡所見であり，胃小区腫大（14.4［5.74-36.1］），萎縮（open type）（15.1［7.35-31.1］）は低酸を有意に示唆する内視鏡所見であった．また，高酸を有意に示唆する内視鏡所見はH. pylori感染の有無によって異なり，H. pylori陽性者ではヘマチン，H. pylori陰性者では前庭部びらんであった．一方，低酸を有意に示唆する内視鏡所見は，H. pylori感染の有無に関わらず一定であった．結論：本研究では，H. pylori感染の有無に関わらず，内視鏡所見から酸分泌能を推定することが可能であった．これらは，酸関連疾患に対するリスク評価の一助となりうる．
Usefulness of Endoscopic Imaging to Visualize Regional Alterations in Acid Secretion of Noncancerous Gastric Mucosa after Helicobacter pylori Eradication 査読有り

Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Yasushi Takahashi, Nobuyuki Ara, Tooru Shimosegawa

JOURNAL OF GASTRIC CANCER　16　(3)　152-160　2016年9月

DOI： 10.5230/jgc.2016.16.3.152 　

ISSN：2093-582X

eISSN：2093-5641
日本における抗血栓薬継続下での内視鏡生検後出血リスクに関する前向き検討査読有り

荒誠之, 今谷晃, 下瀬川徹, 飯島克則, 前嶋隆平, 近藤穣, 日下玄, 八田和久, 宇野要, 浅野直喜, 小池智幸

日本消化器内視鏡学会雑誌　58　(8)　1367-1374　2016年8月
出版者・発行元：一般社団法人日本消化器内視鏡学会
ISSN：0387-1207

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目的：日本では抗血栓薬服用者に対する内視鏡診療ガイドラインの改訂後，抗血栓薬継続下での内視鏡生検が可能になった．しかしながら，内視鏡生検後の出血症例が非常にまれであるため，抗血栓薬継続または休薬下での生検後出血のリスクは未だにはっきりしていない．そのため，今回の前向き検討は抗血栓薬継続下での上部消化管内視鏡生検後の出血リスクを評価することを目的とした． 方法：2011年12月から2014年3月までに上部消化管内視鏡検査にて生検を施行された患者を前向きに検討した．エントリー時に抗血栓薬の継続・休薬状況をチェックし，生検後1カ月以内に外来受診もしくは電話にて出血イベントの有無を確認した． 結果：内視鏡生検を施行した3,758例の中で，394例（10.5％）が抗血栓薬服用者であり，そのうち286例（抗血栓薬服用者の72.6％）が抗血栓薬継続者だった．生検後に出血をきたした症例は6例（0.16％，95％信頼区間；0.09％～0.22％）だったが，抗血栓薬継続者は1例のみだった．生検後出血率は抗血栓薬継続群においても他の群と比較して有意な上昇は認めなかった（0.35％ vs 0.14％，P＝0.38）． 結語：今回の前向き検討において，抗血栓薬継続下でも上部消化管内視鏡生検後の出血リスクは上昇しないことが示された． （UMIN000014369）
Feasibility of optical coherence tomography for the evaluation of Barrett's mucosa buried underneath esophageal squamous epithelium 査読有り

Waku Hatta, Kaname Uno, Tomoyuki Koike, Nobuyuki Ara, Naoki Asano, Katsunori Iijima, Akira Imatani, Fumiyoshi Fujishima, Tooru Shimosegawa

DIGESTIVE ENDOSCOPY　28　(4)　427-433　2016年5月

DOI： 10.1111/den.12576 　

ISSN：0915-5635

eISSN：1443-1661
A Japanese case of lymphocytic esophagitis 査読有り

Ryuhei Maejima, Kaname Uno, Katsunori Iijima, Fumiyoshi Fujishima, Tetsuya Noguchi, Nobuyuki Ara, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

DIGESTIVE ENDOSCOPY　28　(4)　476-480　2016年5月

DOI： 10.1111/den.12578 　

ISSN：0915-5635

eISSN：1443-1661
Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses 査読有り

Naoki Asano, Akira Imatani, Tomohiro Watanabe, Jun Fushiya, Yutaka Kondo, Xiaoyi Jin, Nobuyuki Ara, Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Warren Strober, Tooru Shimosegawa

CANCER RESEARCH　76　(5)　1135-1145　2016年3月

DOI： 10.1158/0008-5472.CAN-15-2272 　

ISSN：0008-5472

eISSN：1538-7445
Gastric cancer development after the successful eradication of Helicobacter pylori 査読有り

Kaname Uno, Katsunori Iijima, Tooru Shimosegawa

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY　8　(3)　271-281　2016年3月

DOI： 10.4251/wjgo.v8.i3.271 　

ISSN：1948-5204
表在型食道癌に対するOptical Coherence Tomography診断の有用性招待有り査読有り

宇野要, 小池智幸, 下瀬川徹

日本気管食道科学会会報　67　(2)　65-65　2016年
出版者・発行元：特定非営利活動法人日本気管食道科学会
DOI： 10.2468/jbes.67.65 　

ISSN：0029-0645
Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients 査読有り

Kenichiro Nakagawa, Tomoyuki Koike, Katsunori Iijima, Masahiro Saito, Hiroki Kikuchi, Waku Hatta, Nobuyuki Ara, Kaname Uno, Naoki Asano, Tooru Shimosegawa

WORLD JOURNAL OF GASTROENTEROLOGY　21　(47)　13352-13359　2015年12月

DOI： 10.3748/wjg.v21.i47.13352 　

ISSN：1007-9327

eISSN：2219-2840
食道ESDにおける内視鏡外付け持続吸引カテーテルの開発

八田和久, 飯島克則, 榛澤崇, 荒誠之, 淺沼清孝, 宇野要, 浅野直喜, 小池智幸, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　57　(Suppl.2)　2119-2119　2015年9月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN：0387-1207

eISSN：1884-5738
Endoscopic findings for predicting gastric acid secretion status 査読有り

Waku Hatta, Katsunori Iijima, Tomoyuki Koike, Yutaka Kondo, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Tooru Shimosegawa

DIGESTIVE ENDOSCOPY　27　(5)　582-589　2015年7月

DOI： 10.1111/den.12427 　

ISSN：0915-5635

eISSN：1443-1661
東北大学病院における経皮的内視鏡的胃瘻造設術(PEG)の動向と合併症の検討

前嶋隆平, 荒誠之, 小池智幸, 遠藤博之, 宇野要, 浅野直喜, 飯島克則, 今谷晃, 下瀬川徹

在宅医療と内視鏡治療　17　(1)　3-7　2013年9月
Collagenous gastritis 査読有り

Xiaoyi Jin, Tomoyuki Koike, Takashi Chiba, Yutaka Kondo, Nobuyuki Ara, Kaname Uno, Naoki Asano, Katsunori Iijima, Akira Imatani, Mika Watanabe, Akio Shirane, Tooru Shimosegawa

Digestive Endoscopy　25　(5)　547-549　2013年9月

DOI： 10.1111/j.1443-1661.2012.01391.x 　

ISSN：0915-5635 1443-1661
Gastric hypochlorhydria is associated with an exacerbation of dyspeptic symptoms in female patients 査読有り

Wataru Iwai, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Naoki Asano, Akira Imatani, Tooru Shimosegawa

Journal of Gastroenterology　48　(2)　214-221　2013年2月

DOI： 10.1007/s00535-012-0634-8 　

ISSN：0944-1174 1435-5922
Biphasic effects of H. pylori infection on low-dose aspirin-induced gastropathy depending on the gastric acid secretion level 査読有り

Katsunori Iijima, Nobuyuki Ara, Yasuhiko Abe, Tomoyuki Koike, Toshimitsu Iwabuchi, Hirohiko Shinkai, Kaname Uno, Hiroyuki Endo, Naoki Asano, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY　47　(12)　1290-1297　2012年12月

DOI： 10.1007/s00535-012-0598-8 　

ISSN：0944-1174
A Pilot Study of Scheduled Endoscopic Balloon Dilation With Oral Agent Tranilast to Improve the Efficacy of Stricture Dilation After Endoscopic Submucosal Dissection of the Esophagus 査読有り

Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Yatsuhiko Abe, Naoki Asano, Nobuyuki Ara, Tooru Shimosegawa

JOURNAL OF CLINICAL GASTROENTEROLOGY　46　(9)　E76-E82　2012年10月

DOI： 10.1097/MCG.0b013e31824fff76 　

ISSN：0192-0790
Endoscopic Submucosal Dissection Combined With Endoscopic Injection Sclerotherapy for Early Gastric Cancer on Gastric Fundal Varices 査読有り

Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Yasuhiko Abe, Naoki Asano, Satoshi Yokosawa, Akira Imatani, Tooru Shimosegawa

SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES　22　(4)　E226-E229　2012年8月

DOI： 10.1097/SLE.0b013e318254d630 　

ISSN：1530-4515
Gastric Cancers Emerging after H. pylori Eradication Arise Exclusively from Non-Acid-Secreting Areas 査読有り

Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Kaname Uno, Hiroyuki Endo, Waku Hatta, Naoki Asano, Kiyotaka Asanuma, Akira Imatani, Tooru Shimosegawa

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　226　(1)　45-53　2012年1月

DOI： 10.1620/tjem.226.45 　

ISSN：0040-8727

eISSN：1349-3329
A case of severe esophageal intramural pseudodiverticulosis whose symptoms were ameliorated by oral administration of anti-fungal medicine 査読有り

Takashi Chiba, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Naoki Asano, Tooru Shimosegawa

Case Reports in Gastroenterology　6　(1)　103-110　2012年1月

DOI： 10.1159/000336846 　

ISSN：1662-0631
Signet ring cell gastric cancer occurring after radiation therapy for helicobacter pylori-uninfected mucosa-associated lymphoid tissue lymphoma 査読有り

Naoki Asano, Katsunori Iijima, Shiho Terai, Kaname Uno, Hiroyuki Endo, Tomoyuki Koike, Wataru Iwai, Toshimitsu Iwabuchi, Waku Hatta, Yasuhiko Abe, Akira Imatani, Tooru Shimosegawa

Case Reports in Gastroenterology　5　(2)　325-329　2011年5月

DOI： 10.1159/000329559 　

ISSN：1662-0631
A Japanese case series of 12 patients with esophageal eosinophilia 査読有り

Yasuhiko Abe, Katsunori Iijima, Shuichi Ohara, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Naoki Asano, Akira Imatani, Katsuaki Kato, Daisuke Shibuya, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY　46　(1)　25-30　2011年1月

DOI： 10.1007/s00535-010-0295-4 　

ISSN：0944-1174
Low Serum Levels of Pepsinogen and Gastrin 17 Are Predictive of Extensive Gastric Atrophy with High-Risk of Early Gastric Cancer 査読有り

Ryousuke Kikuchi, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Kiyotaka Asanuma, Naoki Asano, Akira Imatani, Tooru Shimosegawa

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　223　(1)　35-44　2011年1月

DOI： 10.1620/tjem.223.35 　

ISSN：0040-8727

eISSN：1349-3329
Exogenous luminal nitric oxide exposure accelerates columnar transformation of rat esophagus 査読有り

Hiroyuki Endo, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Hirotaka Ito, Naoki Asano, Kaname Uno, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

INTERNATIONAL JOURNAL OF CANCER　127　(9)　2009-2019　2010年11月

DOI： 10.1002/ijc.25227 　

ISSN：0020-7136

eISSN：1097-0215
Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria 査読有り

Tomoyuki Oikawa, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Toru Horii, Wataru Iwai, Yasuhiko Abe, Naoki Asano, Akira Imatani, Tooru Shimosegawa

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY　45　(11)　1338-1344　2010年11月

DOI： 10.3109/00365521.2010.495419 　

ISSN：0036-5521
超・拡大内視鏡の新展開細胞観察と分子イメージングの現在と未来食道病変におけるOCT(optical coherence tomography)の有用性

八田和久, 宇野要, 小池智幸

Gastroenterological Endoscopy　52　(Suppl.1)　793-793　2010年4月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN：0387-1207

eISSN：1884-5738
A case of gastric duplication with unique eus and endoscopic findings 査読有り

Tomohiro Masaka, Kaname Uno, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Shuichi Ohara, Tooru Shimosegawa, Iwao Sasaki, Mika Watanabe, Akio Shirane

Gastroenterological Endoscopy　52　(1)　51-57　2010年1月

ISSN：0387-1207
Identification of the layered morphology of the esophageal wall by optical coherence tomography 査読有り

Satoshi Yokosawa, Tomoyuki Koike, Yasushi Kitagawa, Waku Hatta, Kaname Uno, Yasuhiko Abe, Katsunori Iijima, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

WORLD JOURNAL OF GASTROENTEROLOGY　15　(35)　4402-4409　2009年9月

DOI： 10.3748/wjg.15.4402 　

ISSN：1007-9327

eISSN：2219-2840
Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication 査読有り

Katsunori Iijima, Tomoyuki Koike, Yasuhiko Abe, Nobuyuki Ara, Kaname Uno, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY　44　(8)　819-825　2009年8月

DOI： 10.1007/s00535-009-0066-2 　

ISSN：0944-1174
Lack of Modulation of Gastric Emptying by Dietary Nitrate in Healthy Volunteers 査読有り

Shiho Terai, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Kaname Uno, Yasuhiko Abe, Tomoyuki Koike, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　218　(1)　73-79　2009年5月

DOI： 10.1620/tjem.218.73 　

ISSN：0040-8727

eISSN：1349-3329
H.pylori感染胃粘膜におけるNotchレセプターならびにId-1の発現

熱海智章, 加藤勝章, 大楽尚弘, 浅沼清孝, 宇野要, 飯島克則, 小池智幸, 今谷晃, 関根仁, 大原秀一, 下瀬川徹

日本消化器病学会雑誌　101　(臨増総会)　A311-A311　2004年3月
出版者・発行元： (一財)日本消化器病学会
ISSN：0446-6586

eISSN：1349-7693

︎全件表示 ︎最初の5件までを表示

MISC 90

予後予測のための新規基礎疾患スコア

佐藤伊佐雄, 八田和久, 中谷久美, 中谷直樹, 尾形洋平, 齊藤真弘, 金笑奕, 宇野要, 小池智幸, 今谷晃, 中村智洋, 正宗淳, 寳澤篤

日本消化器病学会雑誌(Web)　121　2024年

ISSN： 1349-7693
PPI抵抗性GERD患者におけるexcessive supragastric belching(excessive SGB)の食道内逆流因子と有病率の検討

首藤千博, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 谷地一真, 八田和久, 宇野要, 浅野直喜, 正宗淳

日本消化器病学会雑誌(Web)　121　2024年

ISSN： 1349-7693
Barrett食道の発癌に対する食道内逆流因子と食道運動機能の影響

谷地一真, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 首藤千博, 八田和久, 宇野要, 浅野直喜, 正宗淳

日本消化器病学会雑誌(Web)　121　2024年

ISSN： 1349-7693
食道胃接合部癌発育伸展におけるdysbiosis・腸管粘膜バリア傷害の役割

須藤洸一郎, 宇野要, 玉原亨, 草野啓介, 田邊瑞樹, 菅野武, 浅野直喜, 小池智幸, 正宗淳

日本消化器病学会雑誌(Web)　121　2024年

ISSN： 1349-7693
シミュレータ学習プログラムは安全なESTの達成および自覚的習熟度の向上に寄与する前向き教育介入研究

畑山裕, 菅野武, 滝川哲也, 松本諒太郎, 齊藤真弘, 金笑奕, 三浦晋, 八田和久, 濱田晋, 宇野要, 粂潔, 菊田和宏, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

Gastroenterological Endoscopy　65　(Suppl.2)　2026-2026　2023年10月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
【上部消化管疾患の残された課題】非Helicobacter pylori・非NSAIDs潰瘍の診療

菅野武, 川邉誠, 小野義高, 宇野要, 小池智幸, 正宗淳

Progress in Medicine　43　(9)　825-829　2023年9月
出版者・発行元： (株)ライフ・サイエンス
ISSN： 0287-3648
感染性大動脈-十二指腸瘻の診断にビスコクリアを用いた内視鏡観察が有用であった一例

鈴木直生, 齊藤真弘, 宇野要, 金笑奕, 小池智幸, 正宗淳, 赤松大二朗, 水間正道, 亀井尚, 海野倫明

日本消化器病学会東北支部例会・日本消化器内視鏡学会東北支部例会プログラム・抄録集　215回・170回　162-162　2023年7月
出版者・発行元：日本消化器病学会-東北支部
胃がん2次検診で胃粘膜下腫瘍が疑われ,難治性特発性胃潰瘍であった一例

川邉誠, 菅野武, 小野義高, 宇野要, 小池智幸, 正宗淳

日本消化器がん検診学会雑誌　61　(Suppl総会)　476-476　2023年6月
出版者・発行元： (一社)日本消化器がん検診学会
ISSN： 1880-7666

eISSN： 2185-1190
Helicobacter pylori除菌後胃癌の抑止対策 Helicobacter pylori除菌後胃癌の抑止対策

織内優好, 宇野要, 正宗淳

日本消化器病学会雑誌　119　(臨増大会)　A548-A548　2022年10月
出版者・発行元： (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
上部消化管出血患者における,ボノプラザンのPPI内服に対する再出血・死亡リスクの検討傾向スコアを用いたDPCデータベースの解析

阿部寛子, 八田和久, たら澤邦男, 小野義高, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

Gastroenterological Endoscopy　64　(Suppl.2)　2069-2069　2022年10月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
出血を再現した十二指腸ESTシミュレータモデルの開発

畑山裕, 菅野武, 滝川哲也, 齊藤真弘, 金笑奕, 三浦晋, 八田和久, 濱田晋, 宇野要, 粂潔, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

Gastroenterological Endoscopy　64　(Suppl.2)　2138-2138　2022年10月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
上部消化管内視鏡治療におけるP-CABの後出血予防効果 propensity scoreを用いたデータベース解析

阿部寛子, 八田和久, たら澤邦男, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

潰瘍　49　55-55　2022年10月
出版者・発行元： (一社)日本潰瘍学会
ISSN： 2189-7956
早期胃癌ESD後の追加胃切除術における治療成績と安全性の検討

佐々木啓迪, 土屋堯裕, 山村明寛, 田中直樹, 井本博文, 八田和久, 尾形洋平, 宇野要, 小池智幸, 西條文人, 森川孝則, 大沼忍, 正宗淳, 亀井尚, 海野倫明

日本消化器病学会東北支部例会プログラム・抄録集　213回　65-65　2022年7月
出版者・発行元：日本消化器病学会-東北支部
難治性食道狭窄を呈した微小ガストリノーマの1例

草野啓介, 宇野要, 小池智幸, 三浦晋, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 浅野直喜, 今谷晃, 正宗淳, 益田邦洋, 大塚英郎, 海野倫明, 藤島史喜, 中堀昌人

日本消化器病学会東北支部例会誌　212th　2022年
上部消化管内視鏡治療におけるP-CABの後出血予防効果-propensity scoreを用いたデータベース解析-

阿部寛子, 八田和久, たら澤邦男, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

日本消化管学会雑誌(CD-ROM)　6　(Supplement)　2022年

ISSN： 2433-3840
内視鏡的に完全切除した胃平滑筋肉腫の一例

谷地一真, 八田和久, 小池智幸, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 浅野直喜, 今谷晃, 渡邊裕文, 藤島史喜, 正宗淳

日本消化器病学会東北支部例会誌　212th　2022年
【消化管がん検診・スクリーニングの手引き】(第V章)上部消化管の検診で知っておくべき前癌状態と腫瘍性疾患 Barrett食道とBarrett腺癌

小池智幸, 齊藤真弘, 大原祐樹, 八田和久, 宇野要, 正宗淳

臨床消化器内科　36　(8)　982-994　2021年7月
出版者・発行元： (株)日本メディカルセンター
ISSN： 0911-601X

eISSN： 2433-2488
内視鏡医学と基礎医学の融合口腔内雑菌成分刺激による粘膜バリア傷害がピロリ菌除菌後胃発癌機序に関与する

李秀載, 宇野要, 正宗淳

Gastroenterological Endoscopy　63　(Suppl.1)　726-726　2021年4月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
歯周病菌リポ多糖類刺激によるピロリ菌除菌療法後の胃粘膜バリア傷害の検討

織内優好, 宇野要, 李秀載, 齊藤真弘, 中川健一郎, 金笑奕, 菅野武, 八田和久, 浅野直喜, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会雑誌(Web)　118　2021年

ISSN： 1349-7693
新規内視鏡シミュレーターを用いた,消化管止血術学習プログラムによる教育介入研究

畑山裕, 菅野武, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

日本消化器病学会雑誌(Web)　118　2021年

ISSN： 1349-7693
40年に及ぶ疫学的評価による本邦における食道胃接合部腺癌,食道腺癌の増加

畑山裕, 菅野武, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 金村政輝, 正宗淳

日本消化器病学会雑誌(Web)　118　2021年

ISSN： 1349-7693
Helicobacter pylori感染による分化制御遺伝子Notch1の発現抑制を介した胃粘膜萎縮機序の解明

金笑奕, 浅野直喜, 今谷晃, 齋藤方志, 竹内章夫, 斉藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

日本消化器病学会雑誌(Web)　118　2021年

ISSN： 1349-7693
ヘリコバクターピロリ除菌後発見胃癌・未感染胃癌の病態と内視鏡診断ピロリ菌除菌療法後発癌機序における口腔内雑菌の関与

宇野要, 李秀載, 正宗淳

Gastroenterological Endoscopy　62　(Suppl.1)　1135-1135　2020年8月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
ヘリコバクターピロリ除菌後発見胃癌・未感染胃癌の病態と内視鏡診断ピロリ菌除菌療法後発癌機序における口腔内雑菌の関与

宇野要, 李秀載, 正宗淳

Gastroenterological Endoscopy　62　(Suppl.1)　1135-1135　2020年8月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
Barrett食道癌の診断

小池智幸, 齊藤真弘, 大原祐樹, 大方智樹, 阿部泰明, 中川健一郎, 金笑奕, 菅野武, 八田和久, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 菊地亮介, 猪股芳文, 正宗淳

胃と腸　55　(5)　514-529　2020年5月
食道扁平上皮癌における分化制御遺伝子Sox2の発現増強による発癌・血管新生機序の解明

高橋貴一, 浅野直喜, 今谷晃, 金笑奕, 竹内章夫, 齋藤方志, 齊藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

日本消化器病学会雑誌(Web)　117　2020年

ISSN： 1349-7693
除菌後胃癌・Hp未感染胃癌診断の現状と課題ピロリ菌除菌後も残存する萎縮粘膜が除菌後胃癌の内視鏡診断を困難にする

宇野要, 李秀載, 正宗淳

日本消化器病学会雑誌　116　(臨増大会)　A606-A606　2019年11月
出版者・発行元： (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
【食道の炎症を視る】アレルギー性・自己免疫性好酸球性食道炎の診断と治療

浅野直喜, 小池智幸, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 淺沼清孝, 宇野要, 今谷晃, 正宗淳

消化器内視鏡　31　(8)　1179-1184　2019年8月
出版者・発行元： (株)東京医学社
ISSN： 0915-3217
難治性胃潰瘍を呈した好酸球性胃腸炎の一例

大原祐樹, 斉藤真弘, 中川健一郎, 金笑奕, 八田和久, 淺沼清孝, 宇野要, 浅野直喜, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　207回　47-47　2019年7月
出版者・発行元：日本消化器病学会-東北支部
LCIは表在型Barrett食道腺癌の視認性向上に有用である

齊藤真弘, 小池智幸, 八田和久, 阿部泰明, 大方智樹, 金笑奕, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 正宗淳

Gastroenterological Endoscopy　61　(Suppl.1)　892-892　2019年5月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207
BLI・NBI拡大内視鏡による表在型食道扁平上皮癌深達度診断の比較検討

八田和久, 小池智幸, 荒誠之, 近藤穣, 齊藤真弘, 金笑奕, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 正宗淳

Gastroenterological Endoscopy　61　(Suppl.1)　893-893　2019年5月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207
ヘリコバクター・ピロリ感染症の残された課題除菌療法後も残存する萎縮胃粘膜の発癌ポテンシャル

宇野要, 李秀載, 正宗淳

日本消化器病学会雑誌　116　(臨増総会)　A49-A49　2019年3月
出版者・発行元： (一財)日本消化器病学会
ISSN： 0446-6586
食道胃接合部から発生する高濃度一酸化窒素は食道潰瘍の創傷治癒を遅延させる

藤谷拓, 淺沼清孝, 李秀載, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

日本消化器病学会雑誌　116　(臨増総会)　A275-A275　2019年3月
出版者・発行元： (一財)日本消化器病学会
ISSN： 0446-6586
症状の季節変動を繰り返す好酸球性食道筋炎の1例

外田修裕, 宇野要, 齊藤真弘, 金笑奕, 八田和久, 淺沼清孝, 浅野直喜, 小池智幸, 今谷晃, 庄司知隆, 佐藤千晃, 亀井尚, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　206回　85-85　2019年2月
出版者・発行元：日本消化器病学会-東北支部
消化管出血(静脈瘤破裂を除く)の予後不良症例の検討高用量ステロイド投与は出血性胃十二指腸潰瘍内視鏡治療後再出血の危険因子である

八田和久, 小池智幸, 齊藤真弘, 金笑奕, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化管学会雑誌　3　(Suppl.)　157-157　2019年2月
出版者・発行元： (一社)日本消化管学会
ISSN： 2433-3840
消化管出血(静脈瘤破裂を除く)の予後不良症例の検討高用量ステロイド投与は出血性胃十二指腸潰瘍内視鏡治療後再出血の危険因子である

八田和久, 小池智幸, 齊藤真弘, 金笑奕, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化管学会雑誌　3　(Suppl.)　157-157　2019年2月
出版者・発行元： (一社)日本消化管学会
ISSN： 2433-3840
高用量ステロイド投与は出血性胃十二指腸潰瘍内視鏡治療後再出血の危険因子である

八田和久, 小池智幸, 齊藤真弘, 金笑奕, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化管学会雑誌　3　(Supplement)　2019年

ISSN： 2435-8967
飲酒後の食道組織中アセトアルデヒドに関する検討

大方英樹, 八田和久, 飯島克則, 淺沼清孝, 宇野要, 浅野直喜, 小池智幸, 今谷晃, 濱田晋, 正宗淳, 下瀬川徹

日本消化器病学会雑誌　115　(臨増総会)　A266-A266　2018年4月
出版者・発行元： (一財)日本消化器病学会
ISSN： 0446-6586
飲酒後の食道組織中アセトアルデヒドに関する検討

大方英樹, 八田和久, 飯島克則, 淺沼清孝, 宇野要, 浅野直喜, 小池智幸, 今谷晃, 濱田晋, 正宗淳, 下瀬川徹

日本消化器病学会雑誌　115　(臨増総会)　A266-A266　2018年4月
出版者・発行元： (一財)日本消化器病学会
ISSN： 0446-6586
【好酸球性食道炎の診断と治療】好酸球性食道炎の画像診断-内視鏡診断

浅野直喜, 小池智幸, 菅野武, 八田和久, 淺沼清孝, 宇野要, 今谷晃, 下瀬川徹

胃と腸　53　(3)　291-298　2018年3月
出版者・発行元： (株)医学書院
ISSN： 0536-2180
【これでわかる!食道胃接合部疾患】ここまで内視鏡でわかる食道胃接合部の構造と機能

小池智幸, 菊池弘樹, 阿部泰明, 大方智樹, 乗田一明, 八田和久, 淺沼清孝, 宇野要, 浅野直喜, 下瀬川徹

消化器内視鏡　29　(9)　1632-1642　2017年9月
出版者・発行元： (株)東京医学社
ISSN： 0915-3217
MUCOSAL BARRIER DYSFUNCTION MAY DEVELOP GASTRIC CARCINOGENESIS AFTER SUCCESSFUL ERADICATION OF HELICOBACTER PYLORI

Yasushi Takahashi, Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Nobuyuki Ara, Yudai Torihata, Tsugihiro Murata, Kiyotaka Asanuma, Naoki Asano, Tomoyuki Koike, Tooru Shimosegawa

GASTROENTEROLOGY　152　(5)　S738-S738　2017年4月

ISSN： 0016-5085

eISSN： 1528-0012
Intense Gastro-Esophageal Reflux May Influence the Localization of Barrett's Adenocarcinoma: Measured by 24-h pH-Impedance Monitoring

Masahiro Saito, Tomoyuki Koike, Hiroki Kikuchi, Kazuaki Norita, Kenichirou Nakagawa, Takeshi Kanno, Gen Kusaka, Yutaka Kondo, Waku Hatta, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Katsunori Iijima, Tooru Shimosegawa

GASTROENTEROLOGY　150　(4)　S483-S483　2016年4月

ISSN： 0016-5085

eISSN： 1528-0012
PPI抵抗性NERD患者における24hr MLL-pHモニタリングの基線値の検討

菊池弘樹, 小池智幸, 乗田一明, 齊藤真弘, 菅野武, 近藤穣, 日下玄, 八田和久, 荒誠之, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 下瀬川徹

日本消化器病学会雑誌　113　(臨増総会)　A229-A229　2016年3月
出版者・発行元： (一財)日本消化器病学会
ISSN： 0446-6586
GERD、Barrett食道癌の診断と治療とくに治療法の選択について表在型Barrett食道腺癌の内視鏡的特徴と病態および治療に関する検討

齊藤真弘, 小池智幸, 中川健一郎, 菊池弘樹, 八田和久, 荒誠之, 淺沼清孝, 宇野要, 飯島克則, 下瀬川徹

日本食道学会学術集会プログラム・抄録集　69回　21-21　2015年7月
出版者・発行元： (NPO)日本食道学会
The Risk Factors for Metastasis in Non-Ampullary Duodenal Neuroendocrine Tumors Measuring 20 mm or Less in Diameter: a Multicenter Retrospective Trial in Japan

Waku Hatta, Tomoyuki Koike, Katsunori Iijima, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Atsuko Kasajima, Fumiyoshi Fujishima, Hironobu Sasano, Tooru Shimosegawa

GASTROINTESTINAL ENDOSCOPY　81　(5)　AB126-AB126　2015年5月

ISSN： 0016-5107

eISSN： 1097-6779
The Usefulness of Optical Coherence Tomography in Evaluating the Extension of Barrett's Mucosa Underneath the Squamous Epithelium

Waku Hatta, Kaname Uno, Tomoyuki Koike, Nobuyuki Ara, Naoki Asano, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa

GASTROINTESTINAL ENDOSCOPY　81　(5)　AB392-AB392　2015年5月

ISSN： 0016-5107

eISSN： 1097-6779
Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression

Junya Honda, Katsunori Iijima, Gen Kusaka, Yutaka Kondo, Waku Hatta, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

GASTROENTEROLOGY　148　(4)　S740-S741　2015年4月

ISSN： 0016-5085

eISSN： 1528-0012
Effects of Inflammation on Senescence in Epithelial Cells Is Mediated by Fibroblasts in Barrett's Esophagus

Kaname Uno, Marlys Anderson, Lori S. Lutzke, Cadman L. Leggett, Kenneth K. Wang

GASTROENTEROLOGY　146　(5)　S148-S148　2014年5月

ISSN： 0016-5085

eISSN： 1528-0012
当院における頭頸部癌治療後消化管狭窄への内視鏡的バルーン拡張術の検討

前嶋隆平, 飯島克則, 本田純也, 白木健悠, 中川健一郎, 金笑奕, 菅野武, 新海洋彦, 伏谷淳, 近藤穣, 八田和久, 遠藤博之, 荒誠之, 宇野要, 浅野直喜, 小池智幸, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　56　(Suppl.1)　1070-1070　2014年4月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207
Identification of a high-risk group for low-dose aspirin-induced gastropathy by measuring serum pepsinogen in H. pylori-infected subjects.

Iijima, K, Koike, T, Ara, N, Nakagawa, K, Kondo, Y, Uno, K, Hatta, W, Asano, N, Imatani, A, Shimosegawa, T

J Gastroenterol　2014年

DOI： 10.1007/s00535-014-0976-5 　
Diagnosing Dysplasia in Barrett's Esophagus Using Volumetric Laser Endomicroscopy: Submucosal Gland Characteristics

Cadman Leggett, Emmanuel Gorospe, Kaname Uno, Subhash Chandra, Daniel Chan, Marlys Anderson, Lori Lutzke, Kenneth Wang

AMERICAN JOURNAL OF GASTROENTEROLOGY　108　S32-S32　2013年10月

ISSN： 0002-9270

eISSN： 1572-0241
消化管の新たな映像(第10回) Optical coherence tomography(OCT)

八田和久, 飯島克則, 宇野要, 荒誠之, 小池智幸, 下瀬川徹

Frontiers in Gastroenterology　18　(3)　238-243　2013年7月
出版者・発行元： (株)メディカルレビュー社
ISSN： 1342-1484
胃集団検診にて発見された胃腺腫様病変のサーベイランス中にリンパ節転移も伴う粘膜下層浸潤胃型腺癌を認めた一例

荒誠之, 宇野要, 小池智幸, 浅野直喜, 飯島克則, 今谷晃, 下瀬川徹, 菊地亮介, 加藤勝章, 渋谷大助

日本消化器がん検診学会雑誌　51　(1)　131-132　2013年1月
出版者・発行元： (一社)日本消化器がん検診学会
ISSN： 1880-7666
表在性食道扁平上皮癌と胃粘膜萎縮の関係 (特集食道・中下咽頭表在癌の診断と治療)

飯島克則, 宇野要, 小池智幸

消化器内科　55　(4)　413-415　2012年10月
出版者・発行元：科学評論社
ISSN： 1884-2895
食道表在癌(扁平上皮癌・腺癌)に対する内視鏡治療後の予後に関する検討

中川健一郎, 小池智幸, 宇野要, 白木健悠, 金笑奕, 菅野武, 荒誠之, 浅野直喜, 阿部靖彦, 飯島克則, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　54　(Suppl.2)　2840-2840　2012年9月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207
食道胃接合部腺癌・噴門部癌に対する内視鏡治療後の予後に関する検討

中川健一郎, 小池智幸, 宇野要, 白木健悠, 金笑奕, 菅野武, 荒誠之, 浅野直喜, 阿部靖彦, 飯島克則, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　54　(Suppl.2)　2882-2882　2012年9月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207
Influence of Meals on the Pharmacokinetics of Proton Pump Inhibitors in Healthy Japanese Subjects

Hirohiko Shinkai, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Naoki Asano, Yasuhiko Abe, Katsunori Iijima, Akira Imatani, Masamitsu Maekawa, Yotaro Matsumoto, Miki Shimada, Nariyasu Mano, Tooru Shimosegawa

GASTROENTEROLOGY　142　(5)　S215-S215　2012年5月

ISSN： 0016-5085
Gastric Hypochlorhydria is Associated With an Exacerbation of Dyspeptic Symptoms in Female Patients

Wataru Iwai, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Naoki Asano, Akira Imatani, Tooru Shimosegawa

GASTROENTEROLOGY　142　(5)　S468-S468　2012年5月

ISSN： 0016-5085
Paradoxical Effects of H-pylori Infection on Low-Dose Aspirin Induced Gastropathy Depending on the Gastric Acid Secretion Level

Katsunori Iijima, Nobuyuki Ara, Yasuhiko Abe, Tomoyuki Koike, Toshimitsu Iwabuchi, Kaname Uno, Hiroyuki Endo, Naoki Asano, Akira Imatani, Tooru Shimosegawa

GASTROENTEROLOGY　142　(5)　S103-S103　2012年5月

ISSN： 0016-5085
A Prospective Study About the Accuracy of the Preoperative Diagnosis of Invasion Depth of Superficial Esophageal Squamous Cell Carcinoma by Optical Coherence Tomography Compared With That by High-Frequency Endoscopic Ultrasonography

Waku Hatta, Kaname Uno, Tomoyuki Koike, Naoki Asano, Yasuhiko Abe, Katsunori Iijima, Tooru Shimosegawa

GASTROINTESTINAL ENDOSCOPY　75　(4)　127-127　2012年4月

ISSN： 0016-5107
食道表在癌(扁平上皮癌・腺癌)に対する内視鏡治療後の長期経過に関する検討

中川健一郎, 小池智幸, 宇野要, 白木健悠, 金笑奕, 管野武, 荒誠之, 浅野直善, 阿部靖彦, 飯島克則, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　54　(Suppl.1)　1063-1063　2012年4月
出版者・発行元： (一社)日本消化器内視鏡学会
ISSN： 0387-1207
【Helicobacter pylori除菌後の胃癌】 Helicobacter pylori除菌によって何が変わるのか? 胃酸分泌の変化

飯島克則, 小池智幸, 荒誠之, 宇野要, 浅野直喜, 下瀬川徹, 阿部靖彦, 関根仁, 大原秀一

胃と腸　47　(11)　1663-1670　2012年

DOI： 10.11477/mf.1403113622 　
【食道・中下咽頭表在癌の診断と治療】食道表在癌深達度診断におけるOCT(optical coherence tomography)の有効性

宇野要, 八田和久, 横沢聡, 小池智幸, 荒誠之, 浅野直喜, 飯島克則, 今谷晃, 下瀬川徹

消化器内科　55　(4)　424-430　2012年
【Barrett食道癌の診断】主題 Barrett食道癌の内視鏡診断通常観察での拾い上げ診断のポイント

小池智幸, 阿部靖彦, 飯島克則, 中川健一郎, 新海洋彦, 遠藤博之, 荒誠之, 宇野要, 浅野直喜, 今谷晃, 下瀬川徹, 大原秀一

胃と腸　46　(12)　1800-1814　2011年11月
出版者・発行元： (株)医学書院
ISSN： 0536-2180
【変わったぞ「消化管出血のマネジメント」】上部消化管出血性消化性潰瘍に対する止血法純エタノール局注法を中心に

小池智幸, 阿部靖彦, 宇野要, 中川健一郎, 新海洋彦, 千葉隆士, 岩渕利光, 岩井渉, 荒誠之, 浅野直喜, 飯島克則, 今谷晃, 下瀬川徹

消化器内視鏡　23　(11)　1857-1864　2011年11月
出版者・発行元： (株)東京医学社
ISSN： 0915-3217
【Barrett食道腺癌の診断と治療-その問題点と対策-】Barrett食道腺癌のサーベイランスをどう行うか問題点と対策

小池智幸, 阿部靖彦, 飯島克則, 中川健一郎, 新海洋彦, 荒誠之, 宇野要, 今谷晃, 下瀬川徹

消化器の臨床　14　(5)　505-509　2011年10月
出版者・発行元： (株)ヴァンメディカル
ISSN： 1344-3070
Gastric Cancers Emerging After H. pylori Eradication Arise Exclusively From Functionally Irreversible Non-Acid Secreting Areas

Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Hiroyuki Endo, Naoki Asano, Kiyotaka Asanuma, Kaname Uno, Akira Imatani, Tooru Shimosegawa

GASTROENTEROLOGY　140　(5)　S186-S186　2011年5月

ISSN： 0016-5085
Gender Differences in Esophageal Mucosal Injury in a Reflux Esophagitis Model of Rats

Tomohiro Masaka, Katsunori Iijima, Tooru Shimosegawa, Akira Imatani, Tomoyuki Koike, Yasuhiko Abe, Naoki Asano, Kiyotaka Asanuma, Kaname Uno

GASTROENTEROLOGY　140　(5)　S627-S627　2011年5月

ISSN： 0016-5085
The Direct Measurement of Non-Acid Reflux Episodes in Patients With or Without Squamous Cell Carcinoma by 24 Hours pH-Impedance Monitoring

Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Nobuyuki Ara, Waku Hatta, Gen Kusaka, Tooru Shimosegawa

GASTROENTEROLOGY　140　(5)　S669-S669　2011年5月

ISSN： 0016-5085
【Helicobacter pylori除菌後GERDの実態】 Helicobacter pylori除菌後のGERD 発生メカニズムは? (Helicobacter Research)

小池智幸, 飯島克則, 阿部靖彦, 遠藤博之, 浅沼清孝, 宇野要, 浅野直喜, 今谷晃, 下瀬川徹, 大原秀一

Helicobacter Research　15　(1)　32-41　2011年
上腹部症状と胃酸分泌能に関する検討

岩井渉, 阿部靖彦, 小池智幸, 飯島克則, 浅野直喜, 宇野要, 荒誠之, 今谷晃, 下瀬川徹

日本消化器病学会雑誌　107　(臨増大会)　A776-A776　2010年9月
出版者・発行元： (一財)日本消化器病学会
ISSN： 0446-6586
The Use of Optical Coherence Tomography in Staging Tumor Invasion of Superficial Esophageal Squamous Cell Carcinoma

Waku Hatta, Kaname Uno, Tomoyuki Koike, Nobuyuki Ara, Yasuhiko Abe, Katsunori Iijima, Tooru Shimosegawa

GASTROINTESTINAL ENDOSCOPY　71　(5)　AB198-AB199　2010年4月

ISSN： 0016-5107
外因性一酸化窒素(NO)によるバレット食道発生に対する影響について (Therapeutic Research)

遠藤博之, 浅沼清孝, 飯島克則, 荒誠之, 宇野要, 浅野直喜, 阿部靖彦, 小池智幸, 今谷晃, 大原秀一, 下瀬川徹

Therapeutic Research　31　(4)　491-496　2010年4月
【やっぱり大切、基本手技】上部消化管[治療] 局注止血術の基本手技出血性潰瘍に対する純エタノール局注法を中心に (消化器内視鏡)

小池智幸, 阿部靖彦, 宇野要, 飯島克則, 下瀬川徹

消化器内視鏡　22　(4)　501-504　2010年4月
当科に於けるPEGの現状

岩井渉, 荒誠之, 小池智幸, 日下玄, 近藤穣, 真坂智寛, 海上寛之, 八田和久, 伊藤博敬, 遠藤博之, 菊地亮介, 小西秀知, 堀井享, 石山文威, 及川智之, 小林茂之, 寺井志保, 浅沼清孝, 宇野要, 阿部靖彦, 飯島克則, 今谷晃, 朝倉徹, 大原秀一, 下瀬川徹

静脈経腸栄養　25　(2)　627-627　2010年3月
出版者・発行元： (株)ジェフコーポレーション
ISSN： 1344-4980
大学病院に於けるPEG造設の現状

荒誠之, 小池智幸, 岩渕利光, 千葉隆士, 日下玄, 近藤穣, 真坂智寛, 海上寛之, 八田和久, 伊藤博敬, 遠藤博之, 菊地亮介, 小西秀知, 堀井享, 宇野要, 浅野直喜, 阿部靖彦, 飯島克則, 今谷晃, 朝倉徹, 下瀬川徹

静脈経腸栄養　25　(2)　631-631　2010年3月
出版者・発行元： (株)ジェフコーポレーション
ISSN： 1344-4980
【Barrett食道の最前線腺癌発生のメカニズム】食道胃接合部癌の臨床病理学的特徴と病態とくにHelicobacter pylori感染と胃酸分泌の面からみた病態について

阿部靖彦, 大原秀一, 小池智幸, 堀井享, 飯島克則, 浅野直喜, 宇野要, 荒誠之, 今谷晃, 下瀬川徹

G.I.Research　18　(1)　24-30　2010年2月
出版者・発行元： (株)先端医学社
ISSN： 0918-9408
著明な形態変化と非典型的なEUS像を呈した成人胃重複症の1例

眞坂智寛, 宇野要, 阿部靖彦, 飯島克則, 小池智幸, 大原秀一, 下瀬川徹, 佐々木巌, 渡辺みか, 白根昭男

Gastroenterological Endoscopy　52　(1)　51-57　2010年

DOI： 10.11280/gee.52.51 　
【Barrett食道の最前線腺癌発生のメカニズム】食道胃接合部癌の臨床病理学的特徴と病態とくにHelicobacter pylori感染と胃酸分泌の面からみた病態について (G.I.Research)

阿部靖彦, 大原秀一, 小池智幸, 堀井享, 飯島克則, 浅野直喜, 宇野要, 荒誠之, 今谷晃, 下瀬川徹

G.I.Research　18　(1)　24-30　2010年
噴門部小彎からの出血を繰り返し治療に難渋した胃食道静脈瘤の1例

荒誠之, 小池智幸, 宇野要, 浅野直喜, 阿部靖彦, 飯島克則, 今谷晃, 下瀬川徹, 及川圭介, 杉山幸一

日本門脈圧亢進症学会雑誌　15　(1)　95-95　2009年8月
出版者・発行元： (一社)日本門脈圧亢進症学会
ISSN： 1344-8447
食道静脈瘤を伴う食道表在癌に対する内視鏡治療

宇野要, 小池智幸, 飯島克則, 阿部靖彦, 浅野直喜, 荒誠之, 今谷晃, 下瀬川徹, 萱場尚一

日本門脈圧亢進症学会雑誌　15　(1)　108-108　2009年8月
出版者・発行元： (一社)日本門脈圧亢進症学会
ISSN： 1344-8447
【消化管症候群(第2版) その他の消化管疾患を含めて】胃胃粘膜下腫瘍 (日本臨床)

大原秀一, 小池智幸, 阿部靖彦, 宇野要

日本臨床　別冊　(消化管症候群(上))　403-406　2009年7月
【バレット食道の取扱い】 Barrett食道癌を含む食道胃接合部癌の病態 (消化器科)

小池智幸, 堀井享, 阿部靖彦, 荒誠之, 宇野要, 浅野直喜, 飯島克則, 今谷晃, 下瀬川徹

消化器科　49　(1)　62-68　2009年7月
The Aggravative Effect of Gastric Acid On Low Dose Aspirin Induced Gastric Mucosal Injury: Examination By Endoscopic Gastrin Test

Nobuyuki Ara, Katsunori Iijima, Akira Imatani, Tomoyuki Koike, Yasuhiko Abe, Naoki Asano, Kaname Uno, Kiyotaka Asanuma, Shuichi Ohara, Tooru Shimosegawa

GASTROENTEROLOGY　136　(5)　A185-A185　2009年5月

ISSN： 0016-5085
【内視鏡イメージングの進化】 Confocal Endomicroscopy OCTによる食道表在癌深達度診断 (消化器内視鏡)

八田和久, 宇野要, 横沢聡, 阿部靖彦, 飯島克則, 小池智幸, 大原秀一, 下瀬川徹

消化器内視鏡　21　(2)　288-295　2009年
Helicobacter pylori lipopolysaccharide enhances the production of iNOS-derived NO in cooperation with the induction of toll-like receptor (TLR) 2 through TLR4 in gastric epithelial cells

Uno Kaname, Kato Katsuaki, Ohara Shuichi, Shimosegawa Tooru

GASTROENTEROLOGY　130　(4)　A528-A528　2006年4月

ISSN： 0016-5085
Effect of cyclooxygenase activity on nitric oxide from inducible nitric oxide synthase in the gastric mucosa in vivo rat endotoxemia model

K Uno, Y Iuchi, J Fujii, H Sugata, K Iijima, K Kato, T Simosegawa, T Yoshimura

NITRIC OXIDE-BIOLOGY AND CHEMISTRY　11　(1)　102-103　2004年8月

ISSN： 1089-8603
Expression of Notch receptors and Id proteins in human gastric mucosa with H.pylori infection

T Atsumi, K Kato, N Dairaku, K Uno, S Ohara, T Shimosegawa

GASTROENTEROLOGY　126　(4)　A534-A534　2004年4月

ISSN： 0016-5085
Cross-talk between inducible nitric oxide synthase and cyclooxygenase-2 in the gastric mucosa of in vivo rat endotoxemia model

K Uno, K Kato, N Dairaku, S Ohara, Y Iuchi, J Fujii, T Shimosegawa, T Yoshimura

GASTROENTEROLOGY　126　(4)　A614-A614　2004年4月

ISSN： 0016-5085

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 6

歯周病菌が臓器間ネットワークを介して食道胃接合部の炎症性発癌を促進する？

宇野要

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2023年4月～ 2026年3月

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食道胃接合部腺癌とメタボリック症候群(MetS)・歯周病との関連性が疫学研究で報告されたが、機序は明らかとなっていない。歯周病菌はMetSに伴うdysbiosisとともに炎症性発癌を促進させる可能性がある。本研究の目的は、食道胃接合部腺癌の発癌機序におけるメタボリック症候群・歯周病との関連性を、①歯周病菌直接曝露・②高脂肪食摂取によるdysbiosisからの全身性高サイトカイン血症の影響から解析し、明らかにすることである。Ganマウスに対する高脂肪食±リポ多糖刺激の腫瘍進展への影響について、①曝露経路 (局所/全身) ・②自然免疫応答系の関与・③MetS に伴うdysbiosisを介した臓器間ネットワークの関与の点から解析する。現在の進捗状況は、動物実験および細胞実験によって、歯周病菌リポ多糖経口投与による粘膜への直接曝露よりも、高脂肪食経口摂取によるdysbiosis・腸管粘膜バリア傷害およびsystemic endotoxemiaに伴うLPS刺激のほうが強力な腫瘍増大効果が認められ、その機序として、systemic endotoxemiaに伴うLPS刺激による腫瘍内微小環境内のマクロファージがらのTNF刺激が、酸化ストレス応答系・NFkBシグナルを介しPD-L1発現を誘導し、腫瘍進展が促進させることがわかってきた。今後、Nrf2酸化ストレス応答系の役割について遺伝子改変マウスなどNrf2遺伝子制御による影響を追加検討することで、詳細にみていきたい。結果的には、歯周病やdysbiosisを標的とした発癌予防策の新規開発につながることが期待できる。
ピロリ菌除菌後の炎症性発癌過程における口腔内雑菌による胃粘膜バリア傷害機序の解明

宇野要

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2019年4月～ 2022年3月

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胃癌と口腔内雑菌の関連性が報告されたが、機序は不明である。本研究では、口腔内雑菌成分（ペプチドグリカン(PG)＋代謝産物アセトアルデヒド (ALD)）刺激が胃発癌に関与する可能性を明らかにしたい。「除菌後胃癌」背景胃粘膜に腸上皮化生、自然免疫受容体TLR2・酸化ストレスマーカー発現が認められ、PG＋ALD高濃度刺激で有意な粘膜バリア傷害・アポトーシス遺伝子発現が認められた。MKN7ではPG+ALD刺激でTLR2・アポトーシス誘導が認められたが、TLR2shRNA・TLR2中和抗体で抑制された。炎症性胃発癌Ganマウスへの長期投与で、背景粘膜にTLR2-アポトーシス誘導・胃癌進展が認められた。
細胞老化による除菌後胃癌発癌機序の新規解明

宇野要

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2015年4月～ 2018年3月

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胃癌予防としてピロリ菌除菌療法が普及しているが、「除菌後胃癌」が増加し、菌体成分によらない炎症性発癌機序の解明は急務である。慢性炎症に対する生体防御としての細胞老化は興味深い。除菌後発癌過程における細胞老化の関与の可能性を解明することを目的とした。高度萎縮性胃粘膜に対するpH3胆汁酸暴露により、let-7a発現低下→HMGA2-snail発現誘導・ZO-1/E-cadherin発現抑制・細胞老化マーカー発現抑制とともにヒト胃粘膜バリア傷害が惹起されることを解明した。本研究は、除菌後胃内環境においても弱酸性胆汁酸暴露により粘膜バリア傷害が惹起され、炎症性発癌過程が促進する可能性を示唆している。
Helicobacter pylori 除菌後胃癌発癌機序におけるマイクロRNAによる細胞老化制御機構の解明競争的資金

宇野要

2015年4月～ 2016年3月
除菌後胃癌発がんのメカニズム；ＭＵＣ５ＡＣ・ＭＵＣ６発現におけるＨＮＥの役割

宇野要

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2012年4月～ 2015年3月

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現在、Helicobacter pylori除菌療法の適応が拡大し、除菌療法後に認められる除菌後胃癌発癌機序の解明は臨床的課題である。我々は、除菌後胃癌発癌過程における脂質過酸化物4-Hydroxynonenal (HNE)の関与を解明することを目的とした。炎症性細胞浸潤が低下したヒト除菌後胃粘膜組織（非癌・胃癌）においてHNE・p14/p16タンパク発現の蓄積を確認した。しかし、p14/p16メチル化遺伝子発現は除菌療法後酸分泌回復域のみで抑制され、萎縮域では有意な低下は認められず、タンパク・ｍRNA発現動向と異なる。他のepigeneticな異常が関与する可能性が示唆された。
食道扁平上皮癌に対するターゲットとしての脂質過酸化物によるEGFR制御機構の検討競争的資金

宇野要

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2010年4月～ 2012年3月

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食道癌の予後は不良で、90~ 95%は扁平上皮癌である。食道扁平上皮癌の病態形成にEGFR 活性化が関与し、分子標的薬剤の臨床面での有効性も報告されている。HNEは細胞膜脂質過酸化物で、細胞膜に浸透しシグナル伝達機構メディエーターとしての作用も報告されているが、食道扁平上皮癌における役割は不明である。今回、臨床研究・基礎的研究により食道扁平上皮癌の病態形成に重要なEGFR制御機構におけるHNE刺激と生体防御因子GSTA4・GSHとの相互作用の関与を明らかにした。今後の更なる研究により新たな治療方法の開発などへの展開が期待できる。

︎全件表示 ︎最初の5件までを表示

メディア報道 1

メタボリック症候群が胃噴門部腺癌を進展させる機序を解明執筆者本人

東北大学、東北大学東北メガバンク機構　プレスリリース

2025年9月

メディア報道種別: その他