Details of the Researcher

PHOTO

Kaname Uno
Section
Graduate School of Medicine
Job title
Senior Assistant Professor
Degree

Research History 1

  • 2012/07 - 2013/11
    Mayo Clinic, MN　Department of Gastroenterology　Visiting Scientist

Professional Memberships 2

  • American Gastroenterological Association

    2025/08 - Present

  • 日本食道学会

    2025/05 - Present

Research Areas 1

  • Life sciences / Gastroenterology /

Papers 145

  1. Metabolic syndrome develops cardia cancer via nuclear factor-E2-related factor 2-programmed death-ligand 1 signaling Peer-reviewed

    Keisuke Kusano, Kaname Uno, Toru Tamahara, Naoki Asano, Koichiro Sudo, Mizuki Tanabe, Koya Ogasawara, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

    Cellular and Molecular Gastroenterology and Hepatology　101629-101629　2025/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.jcmgh.2025.101629 　

    ISSN： 2352-345X

  2. Co-stimulation with high-fat diet and acidic bile salts may promote Warburg effect in gastric carcinogenesis around the squamo-columnar junction in Gan mice Peer-reviewed

    Koichiro Sudo, Kaname Uno, Toru Tamahara, Naoki Asano, Keisuke Kusano, Mizuki Tanabe, Kouya Ogasawara, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

    American Journal of Physiology-Gastrointestinal and Liver Physiology　2025/04/17

    Publisher: American Physiological Society

    DOI： 10.1152/ajpgi.00305.2024 　

    ISSN： 0193-1857

    eISSN： 1522-1547

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    Epidemiological studies demonstrated relationships between gastric cardia adenocarcinoma (GCA) and metabolic syndrome (MetS). We aimed to clarify mechanism underlying their relationship. To investigate whether systemic inflammation against high-fat diet (HFD)-related dysbiosis promotes Warburg effect in tumors at the squamo-columnar junction (SCJ), we applied K19-Wnt1/C2mE (Gan) mice, fed either HFD or control diet ± acidic bile salts (ABS) with/without clodronate liposomes (CLs), and in vitro studies using MKN7 cells with/without THP1-derived macrophages. Then, we assessed involvement of oxidative stress (OS) in Warburg effect by comparing between nuclear factor-erythroid 2-related factor 2 (Nrf2) knockout-Gan mice and Gan mice. Tumors with macrophage infiltration in HFD+ABS group were larger than in Control group. Gene Set Enrichment Analysis revealed enhancement of the OS signaling in tumor of HFD+ABS group. HFD+ABS group mice demonstrated induction of OS, Nqo1, TNFα, and Warburg effect in tumors and mucosal barrier dysfunction of dysbiotic gut. All of them were abolished with diminishing macrophage infiltration by additional CLs treatment. Stimulation with TNFα, but not ABS nor lipopolysaccharide, on MKN7 cells activated Warburg effect. In MKN7 cells co-cultured with the macrophages whose TNFa expression was induced by the lipopolysaccharide pretreatment, Warburg effect was enhanced in the TNFα concentration-dependent manners. In Nrf2 knockout-Gan mice, tumors shrank with reducing OS, TNFα, and Warburg effect, along with decreasing macrophage infiltration. Accordingly, MetS may develop GCA through the Nrf2-related Warburg effect under the TNFα stimulation from the macrophages activated by both local ABS exposure and systemic lipopolysaccharide exposure from leaky gut with HFD-related dysbiosis.

  3. Porphyromonas gingivalis Lipopolysaccharide Damages Mucosal Barrier to Promote Gastritis-Associated Carcinogenesis International-journal Peer-reviewed

    Masayoshi Oriuchi, Sujae Lee, Kaname Uno, Koichiro Sudo, Keisuke Kusano, Naoki Asano, Shin Hamada, Waku Hatta, Tomoyuki Koike, Akira Imatani, Atsushi Masamune

    Digestive Diseases and Sciences　69　(1)　95-111　2023/11/09

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s10620-023-08142-6 　

    ISSN： 0163-2116

    eISSN： 1573-2568

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    BACKGROUND: Recent epidemiological studies suggested correlation between gastric cancer (GC) and periodontal disease. AIMS: We aim to clarify involvement of lipopolysaccharide of Porphyromonas gingivalis (Pg.), one of the red complex periodontal pathogens, in the GC development. METHODS: To evaluate barrier function of background mucosa against the stimulations, we applied biopsy samples from 76 patients with GC using a Ussing chamber system (UCs). K19-Wnt1/C2mE transgenic (Gan) mice and human GC cell-lines ± THP1-derived macrophage was applied to investigate the role of Pg. lipopolysaccharide in inflammation-associated carcinogenesis. RESULTS: In the UCs, Pg. lipopolysaccharide reduced the impedance of metaplastic and inflamed mucosa with increases in mRNA expression of toll-like receptor (TLR) 2, tumor necrosis factor (TNF) α, and apoptotic markers. In vitro, Pg. lipopolysaccharide promoted reactive oxidative stress (ROS)-related apoptosis as well as activated TLR2-β-catenin-signaling on MKN7, and it increased the TNFα production on macrophages, respectively. TNFα alone activated TLR2-β-catenin-signaling in MKN7, while it further increased ROS and TNFα in macrophages. Under coculture with macrophages isolated after stimulation with Pg. lipopolysaccharide, β-catenin-signaling in MKN7 was activated with an increase in supernatant TNFα concentration, both of which were decreased by adding a TNFα neutralization antibody into the supernatant. In Gan mice with 15-week oral administration of Pg. lipopolysaccharide, tumor enlargement with β-catenin-signaling activation were observed with an increase in TNFα with macrophage infiltration. CONCLUSIONS: Local exposure of Pg. lipopolysaccharide may increase ROS on premalignant gastric mucosa to induce apoptosis-associated barrier dysfunction and to secrete TNFα from activated macrophages, and both stimulation of Pg. lipopolysaccharide and TNFα might activate TLR2-β-catenin-signaling in GC.

  4. Development of Advanced Imaging and Molecular Imaging for Barrett's Neoplasia. International-journal Invited Peer-reviewed

    Kaname Uno, Tomoyuki Koike, Waku Hatta, Masahiro Saito, Mizuki Tanabe, Atsushi Masamune

    Diagnostics (Basel, Switzerland)　12　(10)　2022/10/08

    DOI： 10.3390/diagnostics12102437 　

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    Barrett esophagus (BE) is a precursor to a life-threatening esophageal adenocarcinoma (EAC). Surveillance endoscopy with random biopsies is recommended for early intervention against EAC, but its adherence in the clinical setting is poor. Dysplastic lesions with flat architecture and patchy distribution in BE are hardly detected by high-resolution endoscopy, and the surveillance protocol entails issues of time and labor and suboptimal interobserver agreement for diagnosing dysplasia. Therefore, the development of advanced imaging technologies is necessary for Barrett's surveillance. Recently, non-endoscopic or endoscopic technologies, such as cytosponge, endocytoscopy, confocal laser endomicroscopy, autofluorescence imaging, and optical coherence tomography/volumetric laser endomicroscopy, were developed, but most of them are not clinically available due to the limited view field, expense of the equipment, and significant time for the learning curve. Another strategy is focused on the development of molecular biomarkers, which are also not ready to use. However, a combination of advanced imaging techniques together with specific biomarkers is expected to identify morphological abnormalities and biological disorders at an early stage in the surveillance. Here, we review recent developments in advanced imaging and molecular imaging for Barrett's neoplasia. Further developments in multiple biomarker panels specific for Barrett's HGD/EAC include wide-field imaging systems for targeting 'red flags', a high-resolution imaging system for optical biopsy, and a computer-aided diagnosis system with artificial intelligence, all of which enable a real-time and accurate diagnosis of dysplastic BE in Barrett's surveillance and provide information for precision medicine.

  5. Acidic bile salts induces mucosal barrier dysfunction through let-7a reduction during gastric carcinogenesis after Helicobacter pylori eradication Peer-reviewed

    Yasushi Takahashi, Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Naoki Asano, Kiyotaka Asanuma, Tooru Shimosegawa

    Oncotarget　9　(26)　18069-18083　2018/04/01

    Publisher: Impact Journals LLC

    DOI： 10.18632/oncotarget.24725 　

    ISSN： 1949-2553

  6. Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression Peer-reviewed

    Junya Honda, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Takeharu Shiroki, Yutaka Kondo, Waku Hatta, Kaname Uno, Naoki Asano, Tomoyuki Koike, Tooru Shimosegawa

    DIGESTIVE DISEASES AND SCIENCES　61　(4)　1028-1038　2016/04

    DOI： 10.1007/s10620-015-3980-6 　

    ISSN： 0163-2116

    eISSN： 1573-2568

  7. Role of nitric oxide in the pathogenesis of Barrett's-associated carcinogenesis. Peer-reviewed

    Kusaka G, Uno K, Iijima K, Shimosegawa T

    World journal of gastrointestinal pathophysiology　7　(1)　131-137　2016/02

    DOI： 10.4291/wjgp.v7.i1.131 　

  8. Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies. Peer-reviewed

    Uno K, Koike T, Shimosegawa T

    World journal of gastrointestinal endoscopy　7　(9)　872-880　2015/07

    DOI： 10.4253/wjge.v7.i9.872 　

  9. Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm Peer-reviewed

    Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Tooru Shimosegawa

    WORLD JOURNAL OF GASTROENTEROLOGY　21　(23)　7120-7133　2015/06

    DOI： 10.3748/wjg.v21.i23.7120 　

    ISSN： 1007-9327

    eISSN： 2219-2840

  10. Prospective analysis of risk for bleeding after endoscopic biopsy without cessation of antithrombotics in Japan Peer-reviewed

    Nobuyuki Ara, Katsunori Iijima, Ryuhei Maejima, Yutaka Kondo, Gen Kusaka, Waku Hatta, Kaname Uno, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

    DIGESTIVE ENDOSCOPY　27　(4)　458-464　2015/05

    DOI： 10.1111/den.12407 　

    ISSN： 0915-5635

    eISSN： 1443-1661

  11. Endoscopic balloon dilatation for pharyngo-upper esophageal stricture after treatment of head and neck cancer Peer-reviewed

    Ryuhei Maejima, Katsunori Iijima, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Waku Hatta, Takenori Ogawa, Ken-ichi Watanabe, Yukio Katori, Tooru Shimosegawa

    DIGESTIVE ENDOSCOPY　27　(3)　310-316　2015/03

    DOI： 10.1111/den.12345 　

    ISSN： 0915-5635

    eISSN： 1443-1661

  12. Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy Peer-reviewed

    Kaname Uno, Katsuaki Kato, Tooru Shimosegawa

    WORLD JOURNAL OF GASTROENTEROLOGY　20　(18)　5244-5251　2014/05

    DOI： 10.3748/wjg.v20.i18.5244 　

    ISSN： 1007-9327

    eISSN： 2219-2840

  13. Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan Peer-reviewed

    Kenichiro Nakagawa, Tomoyuki Koike, Katsunori Iijima, Hirohiko Shinkai, Waku Hatta, Hiroyuki Endo, Nobuyuki Ara, Kaname Uno, Naoki Asano, Akira Imatani, Tooru Shimosegawa

    AMERICAN JOURNAL OF GASTROENTEROLOGY　109　(3)　348-356　2014/03

    DOI： 10.1038/ajg.2013.450 　

    ISSN： 0002-9270

    eISSN： 1572-0241

  14. Serious laryngeal edema during endoscopic resection for squamous cell carcinoma of the oesophagus. Peer-reviewed

    Ara Nobuyuki, Uno Kaname, Iijima Katsunori, Koike Tomoyuki, Asano Naoki, Shimosegawa Tooru

    Endoscopy　45　(4)　313-315　2013/04

    DOI： 10.1055/s-0032-1325963 　

  15. The role of nitric oxide in the induction of caudal-type homeobox 2 through epidermal growth factor receptor in the development of Barrett's esophagus Peer-reviewed

    Gen Kusaka, Kaname Uno, Katsunori Iijima, Hiroyuki Endo, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY　47　(10)　1148-1158　2012/10

    DOI： 10.3109/00365521.2012.703232 　

    ISSN： 0036-5521

    eISSN： 1502-7708

  16. A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma Peer-reviewed

    Waku Hatta, Kaname Uno, Tomoyuki Koike, Katsunori Iijima, Naoki Asano, Akira Imatani, Tooru Shimosegawa

    GASTROINTESTINAL ENDOSCOPY　76　(3)　548-555　2012/09

    DOI： 10.1016/j.gie.2012.05.012 　

    ISSN： 0016-5107

  17. Direct Measurement of Gastroesophageal Reflux Episodes in Patients With Squamous Cell Carcinoma by 24-h pH-Impedance Monitoring Peer-reviewed

    Kaname Uno, Katsunori Iijima, Waku Hatta, Tomoyuki Koike, Yasuhiko Abe, Naoki Asano, Gen Kusaka, Tooru Shimosegawa

    AMERICAN JOURNAL OF GASTROENTEROLOGY　106　(11)　1923-1929　2011/11

    DOI： 10.1038/ajg.2011.282 　

    ISSN： 0002-9270

  18. The Balance Between 4-Hydroxynonenal and Intrinsic Glutathione/Glutathione S-Transferase A4 System May Be Critical for the Epidermal Growth Factor Receptor Phosphorylation of Human Esophageal Squamous Cell Carcinomas Peer-reviewed

    Kaname Uno, Katsuaki Kato, Gen Kusaka, Naoki Asano, Katsunori Iijima, Tooru Shimosegawa

    MOLECULAR CARCINOGENESIS　50　(10)　781-790　2011/10

    DOI： 10.1002/mc.20699 　

    ISSN： 0899-1987

    eISSN： 1098-2744

  19. Gastric acid secretion level modulates the association between Helicobacter pylori infection and low-dose aspirin-induced gastropathy Peer-reviewed

    Katsunori Iijima, Nobuyuki Ara, Yasuhiko Abe, Tomoyuki Koike, Wataru Iwai, Kaname Uno, Naoki Asano, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

    JOURNAL OF GASTROENTEROLOGY　46　(5)　612-619　2011/05

    DOI： 10.1007/s00535-011-0385-y 　

    ISSN： 0944-1174

  20. Gastric hyposecretion in esophageal squamous-cell carcinomas. Peer-reviewed

    Iijima K, Koike T, Abe Y, Yamagishi H, Ara N, Asanuma K, Uno K, Imatani A, Nakaya N, Ohara S, Shimosegawa T

    Digestive diseases and sciences　55　(5)　1349-1355　2010/05

    Publisher: 5

    DOI： 10.1007/s10620-009-0853-x 　

    ISSN： 0163-2116

  21. Optical coherence tomography for the staging of tumor infiltration in superficial esophageal squamous cell carcinoma Peer-reviewed

    Waku Hatta, Kaname Uno, Tomoyuki Koike, Satoshi Yokosawa, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa

    GASTROINTESTINAL ENDOSCOPY　71　(6)　899-906　2010/05

    DOI： 10.1016/j.gie.2009.11.052 　

    ISSN： 0016-5107

  22. Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication Peer-reviewed

    Katsunori Iijima, Tomoyuki Koike, Hitoshi Sekine, Yasuhiko Abe, Kiyotaka Asanuma, Nobuyuki Ara, Kaname Uno, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

    JOURNAL OF GASTROENTEROLOGY　44　(1)　47-55　2009/01

    DOI： 10.1007/s00535-008-2270-x 　

    ISSN： 0944-1174

  23. Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells Peer-reviewed

    Kaname Uno, Katsuaki Kato, Tomoaki Atsumi, Takehito Suzuki, Jun Yoshitake, Hidetoshi Morita, Shuichi Ohara, Yashige Kotake, Tooru Shimosegawa, Tetsuhiko Yoshimura

    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　293　(5)　G1004-G1012　2007/11

    DOI： 10.1152/ajpgi.00096.2007 　

    ISSN： 0193-1857

  24. Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer Peer-reviewed

    Tomoaki Atsumi, Katsuaki Kato, Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Akira Imatani, Syuichi Ohara, Tooru Shimosegawa

    PATHOLOGY INTERNATIONAL　57　(10)　635-644　2007/10

    DOI： 10.1111/j.1440-1827.2007.02152.x 　

    ISSN： 1320-5463

  25. In vivo study on cross talk between inducible nitric-oxide synthase and cyclooxygenase in rat gastric mucosa: Effect of cyclooxygenase activity on nitric oxide production Peer-reviewed

    K Uno, Y Iuchi, J Fujii, H Sugata, K Iijima, K Kato, T Shimosegawa, T Yoshimura

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　309　(3)　995-1002　2004/06

    DOI： 10.1124/jpet.103.061283 　

    ISSN： 0022-3565

  26. Antibiotics treatment promotes squamocolumnar junction tumor progression via tumor immune evasion in K19-Wnt1/C2mE mice fed high-fat diet and acidic bile salts

    Koya Ogasawara, Kaname Uno, Toru Tamahara, Naoki Asano, Koichiro Sudo, Keisuke Kusano, Mizuki Tanabe, Yumiko Kaise, Takafumi Shindo, Yusuke Shimoyama, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

    American Journal of Physiology-Gastrointestinal and Liver Physiology　2026/05/22

    Publisher: American Physiological Society

    DOI： 10.1152/ajpgi.00056.2026 　

    ISSN： 0193-1857

    eISSN： 1522-1547

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    Clinical studies suggested that antibiotics (ABx) administration might increase esophagogastric junction adenocarcinoma risk, but the underlying mechanisms remain unclear. We previously demonstrated that the administration of a high-fat diet (HFD) and acid bile salts (ABS) to K19-Wnt1/C2mE mice might promote the metabolic-driven tumor growth at the squamocolumnar junction (SCJ) cooperatively with gut dysbiosis. To clarify whether ABx-induced dysbiosis promotes the tumorigenesis, we evaluated the effects of HFD+ABS ± ABx treatment on tumor immune evasion in mice. In HFD+ABS+ABx-treated mice, SCJ tumor growth with increased tumor cell proliferation and infiltration of inflammatory cells positive for CD8, programmed cell death protein 1 and programmed cell death-ligand 1 (PD-L1) were observed along with apoptosis suppression. Protein expressions of interferon-gamma (IFNγ) and phosphorylated signal transducer and activator of transcription (p-STAT) 3 were upregulated in the tumors of the HFD+ABS+ABx group, whose p-STAT1 expression was equivalent to that of the control group. The mice exhibited insulin resistance and metabolic endotoxemia, and metagenomic analysis of their ileal excrement revealed dysbiosis with a decrease in butyrate-producing bacteria and bacterial butanoate metabolism activity. Moreover, IFNγ stimulation of human-derived NUGC-4 cells increased the protein expression of PD-L1, p-STAT1 and p-STAT3, all of which decreased in response to STAT inhibitors. Transfection with small interfering RNA targeting STAT1 or STAT3 did not attenuate PD-L1 induction, which was inhibited by the combined knockdown. Therefore, oral HFD+ABS+ABx administration to K19-Wnt1/C2mE mice may promote SCJ tumors through tumor immune evasion via IFNγ–STAT1/STAT3–PD-L1 signaling, along with metabolic endotoxemia.

  27. High-fidelity endoscopic submucosal dissection simulator reproducing full-procedure training, bleeding, and perforation

    Takeshi Kanno, Yutaka Hatayama, Suguo Suzuki, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

    Endoscopy　58　(S 01)　E23-E25　2026/01/08

    Publisher: Georg Thieme Verlag KG

    DOI： 10.1055/a-2761-0309 　

    ISSN： 0013-726X

    eISSN： 1438-8812

  28. Epidemiology of dyspepsia and esophagogastroduodenoscopic findings in the era of Helicobacter pylori eradication

    Suguo Suzuki, Takeshi Kanno, Tomoyuki Koike, Takashi Chiba, Kiyotaka Asanuma, Katsuaki Kato, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Waku Hatta, Kaname Uno, Akira Imatani, Atsushi Masamune

    World Journal of Gastroenterology　31　(37)　2025/10/07

    Publisher: Baishideng Publishing Group Inc.

    DOI： 10.3748/wjg.v31.i37.110942 　

    ISSN： 1007-9327

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    BACKGROUND Since Japanese national insurance coverage was expanded to include Helicobacter pylori (H. pylori ) gastritis in 2013, approximately 1.5 million patients have received eradication therapy annually. However, the prevalence and clinical features of uninvestigated dyspepsia in the post-eradication era remain unclear. AIM To evaluate the prevalence of dyspepsia and related endoscopic findings in the general population. METHODS We analyzed data from a gastric cancer screening program using esophagogastroduodenoscopy in Sendai city between 2019 and 2021. Data regarding endoscopic findings, upper gastrointestinal symptoms, and history of H. pylori eradication were collected. Dyspepsia was defined as the presence of upper abdominal pain, bloating, or both. Multivariate logistic regression was used to identify independent factors associated with dyspepsia. RESULTS Among 23250 participants, overall dyspepsia prevalence was 28.0%. It was 28.7% in the non-infected and post-eradication cohorts, and lower (25.8%, P < 0.05) in the currently infected or naturally eradicated cohort. In addition, 23.1% of participants reported heartburn. The following were independently associated with dyspepsia: Age < 60 years, female sex, gastric ulcers, duodenal ulcers, erosive esophagitis, a history of gastric surgery, and successful H. pylori eradication. Gastric or esophageal cancer showed no association. CONCLUSION Uninvestigated dyspepsia remains common even after successful H. pylori eradication. Dyspepsia was not considered a reliable indicator of gastric or esophageal cancer.

  29. Etiology and pathophysiology of Barrett's esophagus/neoplasia. Invited Peer-reviewed

    Asano N., Koike T., Saito M., Hatayama Y., Ogata Y., Jin X., Kanno T., Hatta W., Uno K., Imatani A., Masamune A.

    Digestion　15　1-14　2025/09

    DOI： 10.1159/000548413 　

  30. ダブルバルーン内視鏡下静脈瘤硬化療法が有効であった出血性空腸静脈瘤の1例

    梶浦 大貴, 宇野 要, 小池 智幸, 粂 潔, 畑山 裕, 齋藤 真弘, 小黒 草太, 滝戸 成人, 藤尾 淳, 尾形 洋平, 八田 和久, 下山 雄丞, 志賀 永嗣, 二宮 匡史, 今谷 晃, 高瀬 圭, 亀井 尚, 正宗 淳

    日本門脈圧亢進症学会雑誌　31　(3)　143-143　2025/08

    Publisher: (一社)日本門脈圧亢進症学会

    ISSN： 1344-8447

    eISSN： 2186-6376

  31. ダブルバルーン内視鏡下静脈瘤硬化療法が有効であった出血性空腸静脈瘤の1例

    梶浦 大貴, 宇野 要, 小池 智幸, 粂 潔, 畑山 裕, 齋藤 真弘, 小黒 草太, 滝戸 成人, 藤尾 淳, 尾形 洋平, 八田 和久, 下山 雄丞, 志賀 永嗣, 二宮 匡史, 今谷 晃, 高瀬 圭, 亀井 尚, 正宗 淳

    日本門脈圧亢進症学会雑誌　31　(3)　143-143　2025/08

    Publisher: (一社)日本門脈圧亢進症学会

    ISSN： 1344-8447

    eISSN： 2186-6376

  32. Usefulness of double-balloon endoscopy-assisted injection sclerotherapy for hemorrhagic varices in the jejunum reconstructed for liver transplantation in a pediatric case.

    Hiroki Kajiura, Kaname Uno, Kiyoshi Kume, Tomoyuki Koike, Masahiro Saito, Yusuke Shimoyama, Masashi Ninomiya, Sota Oguro, Kei Takase, Atsushi Masamune

    Clinical journal of gastroenterology　18　(4)　619-625　2025/08

    DOI： 10.1007/s12328-025-02150-x 　

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    A 10-year-old girl was admitted to our hospital for treatment of recurrent melena and severe anemia. Her treatment history comprised Kasai's portoenterostomy for biliary atresia as an infant, followed by liver transplantation and partial splenectomy for portal hypertension at 1 year old. Her medications comprised steroids, immunosuppressive agents, a β-blocker, and a potassium-competitive acid blocker. Since the age of 5 years, she had repeatedly visited a local hospital for melena, but the bleeding source had not been identified. She was referred to our hospital, and laboratory data revealed severe anemia. An enhanced computed tomography showed post-liver transplantation status, splenomegaly, and gastric varices, without extravasation. Esophagogastroduodenoscopy and colonoscopy did not identify the bleeding source. Double-balloon endoscopy (DBE) revealed variceal bleeding and serosanguinous fluid accumulated at the choledochojejunostomy site in the jejunum. After obtaining informed consent, our team and the radiologists cooperatively performed DBE-assisted endoscopic injection sclerotherapy with 75% n-butyl-2-cyanoacrylate through a 23- gage needle according to high-resolution varicerography in a hybrid emergency room. Subsequently, the patient was discharged and regularly monitored without any complications. We demonstrated the first pediatric case of successful DBE-assisted endoscopic injection for hemorrhagic jejunal varices after liver transplantation for biliary atresia and partial splenectomy.

  33. 長期間のステロイド投与を要した好酸球性胃腸炎が、慢性副鼻腔炎に対するデュピルマブ投与により寛解した1例

    清水 翔太, 齊藤 真弘, 小池 智幸, 皆瀬 ゆみ子, 小泉 薫, 畑山 裕, 尾形 洋平, 菅野 武, 八田 和久, 宇野 要, 今谷 晃, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　219回　79-79　2025/07

    Publisher: 日本消化器病学会-東北支部

  34. 日本と海外におけるバレット食道・バレット食道癌の違い 表在型Barrett食道癌(BA)単発例と多発例における逆流因子及び内視鏡的特徴の検討

    小泉 薫, 齊藤 真弘, 小池 智幸, 皆瀬 ゆみ子, 菅原 英之, 首藤 千博, 谷地 一真, 八田 和久, 宇野 要, 正宗 淳

    日本食道学会学術集会プログラム・抄録集　79回　45-45　2025/06

    Publisher: (NPO)日本食道学会

  35. 特発性食道潰瘍がHIV感染症の発見契機となった1例

    菅原 英之, 齊藤 真弘, 宇野 要, 遠藤 悠生, 畑山 裕, 尾形 洋平, 八田 和久, 小池 智幸, 正宗 淳

    日本食道学会学術集会プログラム・抄録集　79回　119-119　2025/06

    Publisher: (NPO)日本食道学会

  36. 日本と海外におけるバレット食道・バレット食道癌の違い 表在型Barrett食道癌(BA)単発例と多発例における逆流因子及び内視鏡的特徴の検討

    小泉 薫, 齊藤 真弘, 小池 智幸, 皆瀬 ゆみ子, 菅原 英之, 首藤 千博, 谷地 一真, 八田 和久, 宇野 要, 正宗 淳

    日本食道学会学術集会プログラム・抄録集　79回　45-45　2025/06

    Publisher: (NPO)日本食道学会

  37. 特発性食道潰瘍がHIV感染症の発見契機となった1例

    菅原 英之, 齊藤 真弘, 宇野 要, 遠藤 悠生, 畑山 裕, 尾形 洋平, 八田 和久, 小池 智幸, 正宗 淳

    日本食道学会学術集会プログラム・抄録集　79回　119-119　2025/06

    Publisher: (NPO)日本食道学会

  38. Associations between excessive supragastric belching and esophageal reflux factors in patients with PPI-refractory GERD in Japan. Peer-reviewed

    Yukihiro Shuto, Masahiro Saito, Tomoyuki Koike, Kaoru Koizumi, Yumiko Kaise, Kazuma Yachi, Yutaka Hatayama, Yohei Ogata, Xiaoyi Jin, Takeshi Kanno, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

    Journal of gastroenterology　2025/05/12

    DOI： 10.1007/s00535-025-02258-4 　

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    BACKGROUND: No studies have evaluated the prevalence of supragastric belching (SGB) in Japanese patients with proton pump inhibitor (PPI)-refractory non-erosive reflux disease (NERD) under off-PPI conditions. This study aimed to clarify the association between excessive SGB and esophageal reflux factors. METHODS: Seventy-nine patients with PPI-refractory NERD under off-PPI treatment were evaluated using 24-h multichannel intraluminal impedance pH monitoring and high-resolution impedance manometry. RESULTS: The prevalence values of excessive SGB overall and in the true NERD, reflux hypersensitivity, and function heartburn subtypes were 19.0%, 35.7%, 5.3%, and 12.5%, respectively. The monitoring results demonstrated that, compared with those without excessive SGB, patients with excessive SGB had a significantly higher total number of reflux events (63 episodes vs. 39 episodes, p = 0.01) and significantly greater acid exposure time (6.1% vs. 1.35%, p = 0.01). However, bolus exposure did not differ significantly between the groups (p = 0.09). The manometry findings showed no significant differences in lower esophageal sphincter pressure, integrated relaxation pressure, and distal contractile integral between the groups. Regarding gastroesophageal reflux, 22% of the SGB episodes were preceded by reflux, 55% occurred independently, and 23% were followed by reflux. CONCLUSIONS: The prevalence of excessive SGB in Japanese patients with PPI-refractory NERD under off-PPI conditions was 19.0% and most commonly observed in patients with true NERD (35.7%). Patients with excessive SGB exhibited increased esophageal acid exposure, and reflux events were sometimes observed before SGB episodes.

  39. 食道疾患に対する内視鏡診療の新展開 頭頸部癌・食道癌治療後狭窄患者における,新型細径処置スコープEG-840TPを用いた上部消化管ESDの検討

    尾形 洋平, 八田 和久, 小池 智幸, 畑山 裕, 齊藤 真弘, 金 笑奕, 菅野 武, 宇野 要, 今谷 晃, 正宗 淳

    日本気管食道科学会会報　76　(2)　85-85　2025/04

    Publisher: (NPO)日本気管食道科学会

    ISSN： 0029-0645

    eISSN： 1880-6848

  40. 機能性消化管疾患の病態と診療の展開 PPI抵抗性NERD患者におけるexcessive supragastric belchingと食道内逆流因子の関連についての検討

    首藤 千博, 齊藤 真弘, 小池 智幸, 小泉 薫, 皆瀬 ゆみ子, 谷地 一真, 八田 和久, 宇野 要, 今谷 晃, 正宗 淳

    日本消化器病学会雑誌　122　(臨増総会)　A52-A52　2025/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  41. 消化管疾患の病態理解を深める研究 経口抗生剤投与が腸管バリア傷害を増悪し食道胃接合部腺癌を進展させる

    小笠原 光矢, 須藤 洸一郎, 宇野 要, 玉原 亨, 浅野 直喜, 正宗 淳

    日本消化器病学会雑誌　122　(臨増総会)　A194-A194　2025/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  42. メタ解析による胃NET Rindi分類におけるリンパ節転移率の比較検討

    尾形 洋平, 八田 和久, 菅野 武, 畑山 裕, 齊藤 真弘, 金 笑奕, 宇野 要, 小池 智幸, 今谷 晃, 正宗 淳

    日本消化器病学会雑誌　122　(臨増総会)　A364-A364　2025/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  43. 多発性内分泌腫瘍症1型を併存する多発十二指腸非機能性NETの一例

    加宅田 公子, 八田 和久, 畑山 裕, 尾形 洋平, 齊藤 真弘, 金 笑奕, 菅野 武, 宇野 要, 小池 智幸, 今谷 晃, 正宗 淳

    日本消化器内視鏡学会東北支部例会　173回　106-106　2025/02

    Publisher: 日本消化器内視鏡学会-東北支部

  44. 生体肝移植術後空腸静脈瘤出血に対し内視鏡的静脈瘤硬化療法を行った1例

    梶浦 大貴, 宇野 要, 粂 潔, 畑山 裕, 齊藤 真弘, 小池 智幸, 尾形 洋平, 金 笑奕, 菅野 武, 八田 和久, 下山 雄丞, 志賀 永嗣, 二宮 匡史, 今谷 晃, 正宗 淳

    日本消化器内視鏡学会東北支部例会　173回　107-107　2025/02

    Publisher: 日本消化器内視鏡学会-東北支部

  45. 消化器疾患診療の現状と近未来・上部消化管・その他の部 細径処置スコープEG-840TPを用いた,咽喉頭癌・食道癌治療後狭窄を有する症例における上部消化管ESDの検討

    尾形 洋平, 八田 和久, 小池 智幸, 畑山 裕, 齊藤 真弘, 金 笑奕, 菅野 武, 宇野 要, 今谷 晃, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　218回　97-97　2025/02

    Publisher: 日本消化器病学会-東北支部

  46. 消化器疾患における基礎研究の役割と展望 歯周病と胃癌罹患との関連性に関する検討

    小笠原 光矢, 宇野 要, 浅野 直喜, 小池 智幸, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　218回　116-116　2025/02

    Publisher: 日本消化器病学会-東北支部

  47. PPI抵抗性NERD患者におけるexcessive supragastric belchingと食道内逆流の関連についての検討

    首藤 千博, 齊藤 真弘, 小池 智幸, 小泉 薫, 皆瀬 ゆみ子, 谷地 一真, 畑山 裕, 尾形 洋平, 金 笑奕, 菅野 武, 八田 和久, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　218回　148-148　2025/02

    Publisher: 日本消化器病学会-東北支部

  48. Barrett食道腺癌における食道運動機能の検討

    谷地 一真, 齊藤 真弘, 小池 智幸, 小泉 薫, 皆瀬 ゆみ子, 首藤 千博, 畑山 裕, 尾形 洋平, 金 笑奕, 菅野 武, 八田 和久, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　218回　148-148　2025/02

    Publisher: 日本消化器病学会-東北支部

  49. 胃穿破を来した膵臓・胃動静脈奇形に対し,内視鏡的止血後に根治的外科切除術を施行した1例

    尾形 洋平, 畑山 裕, 齊藤 真弘, 金 笑奕, 菅野 武, 八田 和久, 宇野 要, 小池 智幸, 今谷 晃, 前田 晋平, 水間 正道, 海野 倫明, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　218回　151-151　2025/02

    Publisher: 日本消化器病学会-東北支部

  50. 【基礎から学ぶ 咽頭・食道内視鏡診断】病変拾い上げのコツ 食道胃接合部観察の基本とコツ

    小池 智幸, 齊藤 真弘, 八田 和久, 小泉 薫, 皆瀬 ゆみ子, 谷地 一真, 首藤 千博, 宇野 要, 正宗 淳

    消化器内視鏡　37　(1)　57-64　2025/01

    Publisher: (株)東京医学社

    ISSN： 0915-3217

  51. H.pylori感染状態とディスペプシアの頻度 成人胃がん検診事業データに基づく疫学的分析

    菅野 武, 鈴木 直生, 小池 智幸, 千葉 隆士, 淺沼 清孝, 加藤 勝章, 畑山 裕, 尾形 洋平, 齊藤 真弘, 金 笑奕, 八田 和久, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    日本ヘリコバクター学会誌　26　(2)　94-96　2025/01

    Publisher: (一社)日本ヘリコバクター学会

    ISSN： 2187-8005

  52. 機能性消化管疾患～最新の診断と治療～[これまでの軌跡と新展開] PPI抵抗性NERD患者におけるexcessive supragastric belchingと食道内逆流因子の関連についての検討

    首藤 千博, 齊藤 真弘, 小池 智幸, 小泉 薫, 皆瀬 ゆみ子, 谷地 一真, 畑山 裕, 尾形 洋平, 八田 和久, 宇野 要, 今谷 晃, 正宗 淳

    日本消化管学会雑誌　9　(Suppl.)　118-118　2025/01

    Publisher: (一社)日本消化管学会

    ISSN： 2433-3840

    eISSN： 2435-8967

  53. Optimal direct oral anticoagulant for upper gastrointestinal endoscopic submucosal dissection. Peer-reviewed

    Yoshitaka Ono, Waku Hatta, Kunio Tarasawa, Yohei Ogata, Hiroko Abe, Isao Sato, Yutaka Hatayama, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Tomoyuki Koike, Akira Imatani, Shin Hamada, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

    Journal of gastroenterology　60　(1)　66-76　2025/01

    DOI： 10.1007/s00535-024-02171-2 　

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    BACKGROUND: The patients taking direct oral anticoagulants (DOACs) are at high risk for developing ischemic stroke and delayed bleeding in upper gastrointestinal endoscopic submucosal dissection (ESD). We aimed to identify the optimal DOAC based on both adverse events in upper gastrointestinal ESD. METHODS: A retrospective population-based cohort study was conducted using the Diagnosis Procedure Combination database in Japan. We included patients on a DOAC undergoing upper gastrointestinal ESD between 2012 and 2021. The primary outcomes were ischemic stroke occurring after upper gastrointestinal ESD and delayed bleeding in gastroduodenal and esophageal ESD. Inverse probability weightings were applied to balance the four DOAC groups (dabigatran, rivaroxaban, apixaban, and edoxaban), and logistic regression analyses were performed to compare the outcomes. RESULTS: We analyzed 9729 patients on a DOAC undergoing upper gastrointestinal ESD. Ischemic stroke developed after upper gastrointestinal ESD in 1.4%, 0.7%, 0.6%, and 0.8% of patients taking dabigatran, rivaroxaban, apixaban, and edoxaban, respectively, after weighting. Rivaroxaban and apixaban showed significantly lower risk of ischemic stroke compared with dabigatran (odds ratio, 0.15 and 0.12, respectively) in standard doses. The delayed bleeding developed after gastroduodenal ESD in 7.6%, 14.6%, 19.2%, and 17.3% of patients taking each DOAC, respectively, with the lowest risk in dabigatran, followed by rivaroxaban. A similar pattern was observed in delayed bleeding in esophageal ESD (3.2%, 5.4%, 7.5%, and 5.5% in each DOAC), but with no significant results. CONCLUSIONS: Rivaroxaban might be an optimal DOAC for upper gastrointestinal ESD showing a lower risk for both ischemic stroke and delayed bleeding.

  54. 高リスク患者における,blue light imaging,linked color imagingによる食道扁平上皮癌スクリーニング 多施設共同ランダム化比較試験

    尾形 洋平, 八田 和久, 小池 智幸, 高橋 壮, 松橋 保, 及川 智之, 岩井 渉, 阿曽沼 祥, 大方 英樹, 大矢内 幹, 伊藤 博敬, 阿部 靖彦, 佐々木 悠, 川村 昌司, 齊藤 真弘, 宇野 要, 藤島 史喜, 中村 智洋, 中谷 直樹, 飯島 克則, 正宗 淳

    Gastroenterological Endoscopy　66　(12)　2694-2705　2024/12

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  55. A case of esophagogastric submucosal hematoma with hemorrhagic shock. Peer-reviewed

    Yumiko Kaise, Kaname Uno, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Tomoyuki Koike, Hideki Ota, Kei Takase, Atsushi Masamune

    Clinical journal of gastroenterology　2024/11/21

    DOI： 10.1007/s12328-024-02069-9 　

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    A 70-year-old woman had been taking steroids for granulomatosis with polyangiitis since the age of 60 years and warfarin for deep vein thrombosis since the age of 63 years. She was admitted to the emergency unit of our hospital in a shock vital with complaints of sudden onset of epigastralgia, nausea, and melena. Laboratory data revealed anemia, hypoalbuminemia, and coagulation disorders. Enhanced computed tomography demonstrated extravasation in the middle part of the gastric body in an extensive submucosal hematoma extending from the upper esophagus to the entire gastric body. Emergency esophagogastroduodenoscopy depicted a large submucosal hematoma and a large amount of fresh blood in the stomach; however, active bleeding was not identified. Two sessions of interventional radiology treatment in the emergency department, followed by an intensive care, successfully treated the patient without any complications. We report a unique case of a sudden-onset esophagogastric submucosal hematoma with hemorrhagic shock requiring an intensive care and interventional radiology treatment. In this case, the extensive warfarization and the fragility in vascular and connective tissue components in the submucosa due to the long-term steroid therapy and the granulomatosis with polyangiitis-related alteration might comprehensively cause severe esophagogastric submucosal hematoma even without any apparent triggers.

  56. A Case of Superficial Esophageal Neuroendocrine Carcinoma with Marked Morphological Changes in a Short Period. Peer-reviewed

    Mizuki Tanabe, Masahiro Saito, Kaname Uno, Tomoyuki Koike, Chiaki Sato, Waku Hatta, Naoki Asano, Fumiyoshi Fujishima, Takashi Kamei, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　2024/11/01

    DOI： 10.2169/internalmedicine.4344-24 　

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    A de novo whitish subepithelial lesion (SEL) with irregular vascular hyperplasia was detected in the lower thoracic esophagus during endoscopic surveillance. Special types of esophageal cancer were suspected; however, endoscopic biopsy specimens were inadequate for a diagnosis. Ten days later, endoscopic ultrasound showed a 7-mm homogeneously hypoechoic round mass in the submucosa, and a biopsy confirmed a histological diagnosis of esophageal neuroendocrine carcinoma (eNEC). Based on the clinical diagnosis of cT2N0M0, subtotal esophagectomy followed by adjuvant chemotherapy was performed immediately after endoscopic reexamination revealing a 20-mm reddish SMT. We herein report the marked changes in endoscopic findings of eNEC within 1.5 months.

  57. 【スキルアップ内視鏡診療】胃・十二指腸 治療 胃ESD後出血予防と対策あれこれ

    八田 和久, 小池 智幸, 尾形 洋平, 宇野 要, 正宗 淳

    消化器内視鏡　36　(増刊)　162-166　2024/10

    Publisher: (株)東京医学社

    ISSN： 0915-3217

  58. 表在型Barrett食道癌の発見契機と特徴に関する検討

    小泉 薫, 齊藤 真弘, 小池 智幸, 谷地 一真, 首藤 千博, 皆瀬 ゆみ子, 畑山 裕, 尾形 洋平, 菅野 武, 金 笑奕, 八田 和久, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    日本消化器がん検診学会雑誌　62　(Suppl大会)　744-744　2024/10

    Publisher: (一社)日本消化器がん検診学会

    ISSN： 1880-7666

    eISSN： 2185-1190

  59. 予後予測のための新規基礎疾患スコア

    佐藤 伊佐雄, 八田 和久, 中谷 久美, 中谷 直樹, 尾形 洋平, 齊藤 真弘, 金 笑奕, 宇野 要, 小池 智幸, 今谷 晃, 中村 智洋, 正宗 淳, 寳澤 篤

    日本消化器病学会雑誌　121　(臨増大会)　A831-A831　2024/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  60. 大学病院における経皮内視鏡的胃瘻造設術の年次推移と合併症の変化

    小笠原 光矢, 金 笑奕, 小池 智幸, 矢野 翔太, 阿部 寛子, 尾形 洋平, 齊藤 真弘, 八田 和久, 宇野 要, 正宗 淳

    在宅医療と内視鏡治療　27　(1)　21-29　2024/09

    Publisher: PEG・在宅医療学会

    ISSN： 1343-1544

    eISSN： 2758-2299

  61. 大学病院における経皮内視鏡的胃瘻造設術の年次推移と合併症の変化 Peer-reviewed

    小笠原 光矢, 金 笑奕, 小池 智幸, 矢野 翔太, 阿部 寛子, 尾形 洋平, 齊藤 真弘, 八田 和久, 宇野 要, 正宗 淳

    在宅医療と内視鏡治療　27　(1)　21-29　2024/09

    Publisher: PEG・在宅医療学会

    ISSN： 1343-1544

    eISSN： 2758-2299

  62. A Case of Gastric Leiomyosarcoma Completely Resected by Endoscopic Submucosal Dissection after a Precise Preoperative Diagnosis. Peer-reviewed

    Kazuma Yachi, Waku Hatta, Tomoyuki Koike, Kimiko Kayada, Naotaro Tanno, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Naoki Asano, Akira Imatani, Hirofumi Watanabe, Fumiyoshi Fujishima, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　2024/08/01

    DOI： 10.2169/internalmedicine.3645-24 　

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    A 68-year-old woman was diagnosed with leiomyosarcoma (LMS) based on preoperative biopsy of the gastric body. As tumor invasion confined to the submucosa with no breaking of the submucosal layer was confirmed on endoscopic ultrasonography (EUS), the patient underwent endoscopic submucosal dissection (ESD) for gastric LMS, resulting in complete tumor resection. No apparent recurrence was observed in the 2.5 years after treatment. This is an extremely rare case of gastric LMS that underwent ESD after a precise preoperative diagnosis, with no signs of recurrence after treatment. ESD may be an acceptable option for gastric LMS when EUS findings allow this treatment method.

  63. The usefulness of gel immersion endoscopy in identifying herald bleeding from an infectious aortoenteric fistula: a case report. Peer-reviewed

    Suguo Suzuki, Masahiro Saito, Kaname Uno, Naoki Asano, Tomoyuki Koike, Daijirou Akamatsu, Masamichi Mizuma, Takashi Kamei, Michiaki Unno, Atsushi Masamune

    Clinical journal of gastroenterology　2024/07/23

    DOI： 10.1007/s12328-024-02020-y 　

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    A 62-year-old male with a history of stent graft replacement for an infectious aortic aneurysm, followed by multiple interventions for postoperative complications, was admitted with melena and anemia. Enhanced computed tomography (eCT) demonstrated fluffing and hyperdensities surrounding the graft, despite no evidence of an aortoenteric fistula (AEF). Emergency esophagogastroduodenoscopy (EGD) showed a massive bleeding in the reconstructed tract and the protruding lesion of postoperative granulation tissue with clots at the end of the blind pouch. Thereafter, hemorrhage temporarily reoccurred several times; however, the source could not be identified using eCT or EGD. Finally, on the third attempt, we performed gel immersion endoscopy (GIE) with manual injection of VISCOCLEARⓇ, and it showed purulent blood flowing from one side of the protruding lesion in the pouch. Based on the eCT findings showing exudation of the contrast agent from the graft into the pouch, we made a diagnosis of an AEF. However, radical surgery was not performed because of the patient's poor general condition. During conservative management, he died of uncontrolled bleeding from the AEF on the 5th day of hospitalization. This is the first case in which the GIE might provide tips to identify herald bleeding from a lethal AEF.

  64. The Impact of Tobacco Smoking and Alcohol Consumption on the Development of Gastric Cancers. International-journal Invited Peer-reviewed

    Waku Hatta, Tomoyuki Koike, Naoki Asano, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Akira Imatani, Atsushi Masamune

    International journal of molecular sciences　25　(14)　2024/07/18

    DOI： 10.3390/ijms25147854 　

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    Chronic infection of Helicobacter pylori is considered the principal cause of gastric cancers, but evidence has accumulated regarding the impact of tobacco smoking and alcohol consumption on the development of gastric cancers. Several possible mechanisms, including the activation of nicotinic acetylcholine receptors, have been proposed for smoking-induced gastric carcinogenesis. On the other hand, local acetaldehyde exposure and ethanol-induced mucosal inflammation have been proposed as the mechanisms involved in the development of gastric cancers in heavy alcohol drinkers. In addition, genetic polymorphisms are also considered to play a pivotal role in smoking-related and alcohol-related gastric carcinogenesis. In this review, we will discuss the molecular mechanisms involved in the development of gastric cancers in relation to tobacco smoking and alcohol consumption.

  65. 術前確定診断が困難であったEBV関連リンパ球浸潤胃癌の一例

    丹野 尚太郎, 八田 和久, 畑山 裕, 尾形 洋平, 齊藤 真弘, 金 笑奕, 菅野 武, 宇野 要, 小池 智幸, 今谷 晃, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　217回　91-91　2024/07

    Publisher: 日本消化器病学会-東北支部

  66. Risk stratification of synchronous gastric cancers including alcohol-related genetic polymorphisms. International-journal Peer-reviewed

    Sho Asonuma, Waku Hatta, Tomoyuki Koike, Hideki Okata, Kaname Uno, Wataru Iwai, Masashi Saito, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Hirotaka Ito, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Shusuke Toda, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Kenji Kinoshita, Madoka Kisoi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

    Journal of gastroenterology and hepatology　2024/04/16

    DOI： 10.1111/jgh.16570 　

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    BACKGROUND AND AIM: We previously identified that ever-smoking and severe gastric atrophy in pepsinogen are risk factors for synchronous gastric cancers (SGCs). This study aimed to determine the association of alcohol drinking status or alcohol-related genetic polymorphism with SGCs and also stratify their risk. METHODS: This multi-center prospective cohort study included patients who underwent endoscopic submucosal dissection for the initial early gastric cancers at 22 institutions in Japan. We evaluated the association of alcohol drinking status or alcohol dehydrogenase 1B (ADH1B) and acetaldehyde dehydrogenase 2 (ALDH2) genotypes with SGCs. We then stratified the risk of SGCs by combining prespecified two factors and risk factors identified in this study. RESULTS: Among 802 patients, 130 had SGCs. Both the ADH1B Arg and ALDH2 Lys alleles demonstrated a significant association with SGCs on multivariate analysis (odds ratio, 1.77), although alcohol drinking status showed no association. The rates of SGCs in 0-3 risk factors in the combined evaluation of three risk factors (ever-smoking, severe gastric atrophy in pepsinogen, and both the ADH1B Arg and ALDH2 Lys alleles) were 7.6%, 15.0%, 22.0%, and 32.1%, respectively. The risk significantly increased from 0 to 3 risk factors on multivariate analysis (P for trend <0.001). CONCLUSIONS: Both the ADH1B Arg and ALDH2 Lys alleles were at high risk for SGCs. The risk stratification by these three factors may be a less invasive and promising tool for predicting their risk.

  67. Is blue light imaging without magnification satisfactory as screening for esophageal squamous cell carcinoma? Post-hoc analysis of multicenter randomized controlled trial. International-journal Peer-reviewed

    Yohei Ogata, Waku Hatta, Tomoyuki Koike, So Takahashi, Tamotsu Matsuhashi, Wataru Iwai, Sho Asonuma, Hideki Okata, Motoki Ohyauchi, Hirotaka Ito, Yasuhiko Abe, Yu Sasaki, Masashi Kawamura, Masahiro Saito, Kaname Uno, Fumiyoshi Fujishima, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　2024/03/17

    DOI： 10.1111/den.14788 　

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    OBJECTIVES: Narrow light observation is currently recommended as an alternative to Lugol chromoendoscopy (LCE) to detect esophageal squamous cell carcinoma (ESCC). Studies revealed little difference in sensitivity between the two modalities in expert settings; however, these included small numbers of cases. We aimed to determine whether blue light imaging (BLI) without magnification is satisfactory for preventing misses of ESCC. METHODS: This was a post-hoc analysis of a multicenter randomized controlled trial targeting patients at high risk of ESCC in expert settings. In this study, BLI without magnification followed by LCE was performed. The evaluation parameters included: (i) the diagnostic abilities of ESCC; (ii) the endoscopic characteristics of lesions with diagnostic differences between the two modalities; and (iii) the color difference between cancerous and noncancerous areas in BLI and LCE. RESULTS: This study identified ESCC in 49 of 699 cases. Of these cases, nine (18.4%) were missed by BLI but detected by LCE. In per-patient analysis, the sensitivity of BLI was lower than that of LCE following BLI (83.7% vs. 100.0%; P = 0.013), whereas the specificity and accuracy of BLI were higher (88.2% vs. 81.2%; P < 0.001 and 87.8% vs. 82.5%; P < 0.001, respectively). No significant endoscopic characteristics were identified, but the color difference was lower in BLI than in LCE (21.4 vs. 25.1; P = 0.003). CONCLUSION: LCE following BLI outperformed BLI in terms of sensitivity in patients with high-risk ESCC. Therefore, LCE, in addition to BLI, would still be required in screening esophagogastroduodenoscopy even by expert endoscopists.

  68. Interactive training with a novel simulation model for upper gastrointestinal endoscopic hemostasis improves trainees’ technique and confidence International-journal Peer-reviewed

    Takeshi Kanno, Yutaro Arata, Eric Greenwald, Paul Moayyedi, Suguo Suzuki, Yutaka Hatayama, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Yutaka Kagaya, Tomoyuki Koike, Atsushi Masamune

    Endoscopy International Open　12　(2)　E245-E252　2024/01/17

    Publisher: Georg Thieme Verlag KG

    DOI： 10.1055/a-2248-5110 　

    ISSN： 2364-3722

    eISSN： 2196-9736

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    Background and study aims: Endoscopic hemostasis is a life-saving procedure for gastrointestinal bleeding; however, its training is often performed on real patients and during urgent situations that put patients at risk. Reports of simulation-based training models for endoscopic hemostasis are scarce. Herein, we developed a novel simulator called “Medical Rising STAR-Ulcer type” to practice endoscopic hemostasis with hemoclips and coagulation graspers. This study aimed to evaluate the reproducibility of the clinical difficulty of this model and the effectiveness of simulation-based training for clipping hemostasis.Patients and methods: This was a prospective educational study. Fifty gastroenterology resident doctors from Japan and Canada were recruited to participate in a simulation-based training program. The primary outcome was the success rate of clipping hemostasis. We measured differences in trainees’ subjective assessment scores and evaluated the co-occurrence network based on comments after training.Results: The hemostasis success rate of the trainees significantly increased after instruction (64% vs. 86%, p&lt;0.05). The success rate for ulcers in the upper body of the stomach (59%), a high-difficulty site, was significantly lower than that for ulcers in the antrum, even after feedback and instruction. Trainees’ self-perceived proficiency and confidence significantly improved after simulation-based training (p&lt;0.05). Co-occurrence network analysis showed that trainees valued a structured learning approach, acknowledged the simulator’s limitations, and recognized the need for continuous skill refinement. Conclusions: Our study demonstrates the potential of our simulation-based training model as a valuable tool for improving technical skills and confidence in trainees learning to perform endoscopic hemostasis.

  69. A novel dry simulator model for learning comprehensive endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomy procedures while minimizing adverse bleeding events (with Video). International-journal Peer-reviewed

    Yutaka Hatayama, Takeshi Kanno, Tetsuya Takikawa, Ryotaro Matsumoto, Yutaro Arata, Suguo Suzuki, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Shin Miura, Waku Hatta, Shin Hamada, Kaname Uno, Kiyoshi Kume, Kazuhiro Kikuta, Naoki Asano, Akira Imatani, Tomoyuki Koike, Atsushi Masamune

    Digestion　105　(2)　149-156　2024/01/10

    DOI： 10.1159/000536217 　

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    BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincterotomy (EST) are essential skills for endoscopic cholangio-pancreatic procedures. However, these procedures have a high incidence of adverse events, and most training is currently patient-based. Herein, we aimed to develop an ERCP/EST simulator model to address the need for safer training alternatives, especially for learners with limited ERCP experience. METHODS: The model was designed to facilitate the use of actual endoscopic devices, supporting learning objectives that align with the components of the validated Bethesda ERCP Skill Assessment Tool (BESAT). BESAT focuses on skills such as papillary alignment and maintenance of duodenoscope position, gentle and efficient cannulation, controlled sphincterotomy in the correct trajectory, and guidewire manipulation. Thirty gastroenterology trainees used the simulator between May 2022 and March 2023, and their satisfaction was assessed using a visual analog scale (VAS) and pre- and post-training questionnaires. RESULTS: The novel simulator model comprises a disposable duodenal papillary portion, suitable for incision with an electrosurgical knife, alongside washable upper gastrointestinal tract and bile duct portions, designed for repeated use. The duodenal papillary portion enabled reproduction of a realistic endoscope position and the adverse bleeding events due to improper incisions. The bile duct portion allowed for the reproduction of fluoroscopic-like images, enabling learners to practice guidewire guidance and insert other devices. After training, the median VAS score reflecting the expectation for model learning significantly increased from 69.5 (interquartile range [IQR]:55.5-76.5) to 85.5 (IQR: 78.0-92.0) (P<0.01). All participants expressed their desire for repeated simulator training sessions. CONCLUSIONS: This innovative simulator serves as a practical educational tool, particularly beneficial for novices in ERCP. It facilitates hands-on practice with actual devices, enhancing procedural fluency and understanding of precise incisions to minimize the risk of bleeding complications during EST.

  70. 胃瘻抜去後の瘻孔閉鎖不全に対してOTSCが有用であった一例

    小笠原 光矢, 金 笑奕, 小池 智幸, 畑山 裕, 尾形 洋平, 齊藤 真弘, 菅野 武, 八田 和久, 宇野 要, 正宗 淳

    学会誌JSPEN　6　(Suppl.2)　494-495　2024

    Publisher: (一社)日本栄養治療学会

    eISSN： 2434-4966

  71. ピロリ菌総除菌時代における炎症性胃発癌への歯周病菌の関与 Invited Peer-reviewed

    織内 優好, 宇野 要, 李 秀載, 浅野 直喜, 小池 智幸, 正宗 淳

    日本ヘリコバクター学会誌　25　(2)　139-142　2024/01

    Publisher: (一社)日本ヘリコバクター学会

    ISSN： 2187-8005

  72. A case of refractory bleeding from duodenal angioectasia with acquired hemophilia A. Peer-reviewed

    Hiroko Abe, Masahiro Saito, Kaname Uno, Tomoyuki Koike, Satoshi Ichikawa, Masashi Saito, Takeshi Kanno, Waku Hatta, Naoki Asano, Atsushi Masamune

    Clinical journal of gastroenterology　16　(3)　355-360　2023/06

    DOI： 10.1007/s12328-023-01790-1 　

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    Acquired hemophilia A (AHA) is a coagulation disorder related to the factor VIII inhibitors, which might cause intractable bleeding of gastrointestinal tracts. However, its scarcity makes it difficult to recognize AHA as a pitfall of endoscopic hemostasis failure. An 81-year-old female with a history of endoscopic treatment for colon polyps visited a local hospital with chief compliments of bloody stool and severe anemia. During several examinations for the bleeding origin, esophagogastroduodenoscopy depicted a 5 mm-sized hemorrhagic angioectasia of the duodenum, followed by treatment with argon plasma coagulation. However, hemostasis was not achieved by multiple sessions of endoscopic hemostasis and transcatheter arterial embolization, so blood transfusion was repeatedly done and she was transferred to our hospital. Laboratory data showed severe anemia with coagulation disorder. Based on the results of von Willebrand factor activity, factor VIII activity and factor VIII inhibitor, we diagnosed AHA as a comorbidity. Endoscopic hemostasis was confirmed only after improvement of APTT level and negative for the factor VIII inhibitor by hemostatic bypass treatment with recombinant active factor VII and immunosuppressive therapy with prednisolone and cyclophosphamide. In case of refractory bleeding of gastrointestinal tract, we should suspect of a comorbidity of coagulation disorder like AHA.

  73. Role of T-box transcription factor 3 in gastric cancers. International-journal Invited Peer-reviewed

    Naoki Asano, Akira Imatani, Akio Takeuchi, Masashi Saito, Xiao-Yi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

    World journal of gastrointestinal pathophysiology　14　(2)　12-20　2023/03/22

    DOI： 10.4291/wjgp.v14.i2.12 　

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    The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.

  74. Blue light imaging and linked color imaging as a screening mode for esophageal squamous cell carcinoma in high-risk patients: A multicenter randomized trial. International-journal Peer-reviewed

    Yohei Ogata, Waku Hatta, Tomoyuki Koike, So Takahashi, Tamotsu Matsuhashi, Tomoyuki Oikawa, Wataru Iwai, Sho Asonuma, Hideki Okata, Motoki Ohyauchi, Hirotaka Ito, Yasuhiko Abe, Yu Sasaki, Masashi Kawamura, Masahiro Saito, Kaname Uno, Fumiyoshi Fujishima, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　2023/02/18

    DOI： 10.1111/den.14538 　

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    OBJECTIVES: Blue light imaging (BLI) and linked color imaging (LCI) are superior to conventional white light imaging for detecting esophageal squamous cell carcinoma (ESCC). Hence, we compared their diagnostic performances in ESCC screening. METHODS: This open-labeled, randomized controlled trial was performed at seven hospitals. Patients with a high risk of ESCC were randomly assigned to the BLI group (BLI followed by LCI) and LCI group (LCI followed by BLI). The primary endpoint was the detection rate of ESCC in the primary mode. The main secondary endpoint was its miss rate in the primary mode. RESULTS: In total, 699 patients were enrolled. The detection rate of ESCC did not significantly differ between the BLI and LCI groups [4.0% (14/351) vs. 4.9% (17/348); p = 0.565]; however, the number of patients with ESCC tended to be smaller in the BLI group (19 vs. 30). Notably, the miss rate of ESCC was lower in the BLI group [26.3% (5/19) vs. 63.3% (19/30); p = 0.012] and LCI detected no ESCCs missed by BLI. The sensitivity was higher in BLI (75.0% vs. 47.6%; p = 0.042); on the other hand, the positive predictive value in BLI tended to be lower (28.8% vs. 45.5%; p = 0.092). CONCLUSIONS: The detection rates of ESCC did not significantly differ between BLI and LCI. Although BLI may have a potential to be advantageous over LCI for the diagnosis of ESCC, it is still unclear whether BLI is superior to LCI, and a further large-scale study is needed.

  75. Smoking history and severe atrophic gastritis assessed by pepsinogen are risk factors for the prevalence of synchronous gastric cancers in patients with gastric endoscopic submucosal dissection: a multicenter prospective cohort study. Peer-reviewed

    Waku Hatta, Tomoyuki Koike, Sho Asonuma, Hideki Okata, Kaname Uno, Tomoyuki Oikawa, Wataru Iwai, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Motoki Ohyauchi, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Kazuaki Norita, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

    Journal of gastroenterology　58　(5)　433-443　2023/02/14

    DOI： 10.1007/s00535-023-01967-y 　

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    BACKGROUND: No studies have evaluated the relationship between lifestyle and synchronous gastric cancers (SGCs) in patients with endoscopic submucosal dissection (ESD) for early gastric cancers (EGCs). Using data from the Tohoku gastrointestinal (GI) study, we aimed to identify factors associated with SGCs. METHODS: Tohoku GI study is a multicenter prospective cohort study investigating the relationship between lifestyle and metachronous gastric cancers. Patients who had a schedule to undergo ESD for primary EGCs were enrolled. We used logistic regression analysis to examine the relationship of 15 candidate factors, including lifestyle, with the prevalence of SGCs in this study. RESULTS: Of 850 patients between 2016 and 2019, 16.0% (136 patients) had SGCs. In multivariate analysis, smoking history (odds ratio [OR], 1.93; p = 0.048) and severe atrophic gastritis assessed by pepsinogen (OR, 1.92; p = 0.004) were risk factors for the prevalence of SGCs. Regarding smoking, current smoking (OR, 2.33; p = 0.021), but not former smoking (OR, 1.76; p = 0.098), was a significant risk factor for its prevalence. In the stratified analysis, severe atrophic gastritis assessed by pepsinogen was a risk factor in patients without Helicobacter pylori (H. pylori) eradication (OR, 2.10; p = 0.002), but not a risk factor in those with H. pylori eradication (OR, 0.75; p = 0.737). CONCLUSION: Smoking history was a risk factor for the prevalence of SGCs in patients with ESD for EGCs, and severe atrophic gastritis assessed by pepsinogen was also a risk factor when H. pylori was not eradicated.

  76. 早期胃癌治療後の早期・後期死亡関連因子

    尾形 洋平, 八田 和久, 大原 祐樹, 小池 智幸, 阿部 寛子, 齊藤 真弘, 金 笑奕, 菅野 武, 宇野 要, 浅野 直喜, 今谷 晃, 山村 明寛, 田中 直樹, 亀井 尚, 海野 倫明, 中村 智洋, 中谷 直樹, 正宗 淳

    Gastroenterological Endoscopy　65　(2)　162,np1-np9　2023/02

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  77. Similar Effect of Vonoprazan and Oral Proton Pump Inhibitors for Preventing Rebleeding in Cases of Upper Gastrointestinal Bleeding Peer-reviewed

    Hiroko Abe, Kunio Tarasawa, Waku Hatta, Tomoyuki Koike, Isao Sato, Yoshitaka Ono, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

    Internal Medicine　2023

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.2211-23 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  78. Discrepancy between Abdominal Symptoms and Endoscopic Findings in Patients with Gastro-duodenal Eosinophilia: A Case Series Peer-reviewed

    Hideyuki Sugawara, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Tomoyuki Koike, Atsushi Masamune

    Internal Medicine　2023

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.1137-22 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  79. Wnt Signaling and Aging of the Gastrointestinal Tract Peer-reviewed

    Naoki Asano, Akio Takeuchi, Akira Imatani, Masashi Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

    International Journal of Molecular Sciences　23　(20)　12210-12210　2022/10/13

    Publisher: MDPI AG

    DOI： 10.3390/ijms232012210 　

    eISSN： 1422-0067

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    Aging is considered a risk factor for various diseases including cancers. In this aging society, there is an urgent need to clarify the molecular mechanisms involved in aging. Wnt signaling has been shown to play a crucial role in the maintenance and differentiation of tissue stem cells, and intensive studies have elucidated its pivotal role in the aging of neural and muscle stem cells. However, until recently, such studies on the gastrointestinal tract have been limited. In this review, we discuss recent advances in the study of the role of Wnt signaling in the aging of the gastrointestinal tract and aging-related carcinogenesis.

  80. A Case of Duodenal Variceal Rupture during Atezolizumab and Bevacizumab Treatment for Hepatocellular Carcinoma. Peer-reviewed

    Mio Tsuruoka, Jun Inoue, Keishi Ouchi, Kaname Uno, Hideaki Itami, Masashi Ninomiya, Tomoaki Iwata, Akitoshi Sano, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Tomoyuki Koike, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　2022/10/05

    DOI： 10.2169/internalmedicine.0629-22 　

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    Duodenal varices are detected infrequently, and their rupture is very rare. We encountered an 87-year-old man who developed duodenal varices rupture during chemotherapy with atezolizumab and bevacizumab (ATZ/BV) for hepatocellular carcinoma. We identified massive bleeding of a ruptured varix in the horizontal portion of the duodenum with emergency esophagogastroduodenoscopy (EGD). Successful hemostasis was achieved by endoscopic injection sclerotherapy with Histoacryl. Although ATZ/BV can cause esophageal varices rupture, there have been no cases of duodenal varices rupture. We should take care to check the duodenal varices as well as esophagogastric varices before ATZ/BV treatment.

  81. A case of refractory esophageal stricture due to occult gastrinoma of the duodenum. Peer-reviewed

    Keisuke Kusano, Kaname Uno, Tomoyuki Koike, Shin Miura, Kiyoshi Kume, Masato Nakahori, Fumiyoshi Fujishima, Hideo Ohtsuka, Michiaki Unno, Atsushi Masamune

    Clinical journal of gastroenterology　15　(5)　859-863　2022/10

    DOI： 10.1007/s12328-022-01657-x 　

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    Gastrinoma may cause refractory esophageal stricture due to gastro-esophageal reflux disease (GERD), but imaging technologies have limited power in its diagnosis. A 74-year-old female with a history of peptic ulcers suffered from repeated epigastralgia, and she visited a local hospital. An esophago-gastro-duodenoscopy (EGD) demonstrated severe reflux esophagitis and multiple peptic ulcers. Blood examination revealed a high value of fasting serum gastrin. Multi-detector computed tomography showed a hypervascular and tiny nodule in duodenal bulb, although other imaging technologies did not. Short-term medication with a proton pump inhibitor or potassium-competitive acid blocker was intermittently provided, but dysphagia was repeatedly worsened, and she was referred to our division. Serum hypergastrinemia was retained, and EGD reexamination depicted esophageal stricture, treated by multiple sessions of endoscopic balloon dilatation. Primary tumor was not identified by the morphological imaging technologies, but a selective arterial secretagogue injection test suggested its existence in the duodenum or pancreatic head. Pancreaticoduodenectomy was performed, and histological study identified 2 mm-sized microgastrinoma buried in Brunner`s glands on the posterior wall of the duodenum bulb. We reported a case with difficulty in diagnosis of the smallest sporadic gastrinoma of the duodenum, which might cause refractory GERD-associated stricture.

  82. Management of Superficial Esophageal Squamous Cell Carcinoma and Early Gastric Cancer following Non-Curative Endoscopic Resection. International-journal Invited Peer-reviewed

    Waku Hatta, Tomoyuki Koike, Kaname Uno, Naoki Asano, Atsushi Masamune

    Cancers　14　(15)　2022/08/02

    DOI： 10.3390/cancers14153757 　

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    According to the European and Japanese guidelines, additional treatment is recommended for cases of superficial esophageal squamous cell carcinoma (ESCC) and early gastric cancer (EGC) that do not meet the curability criteria for endoscopic resection (ER), i.e., non-curative ER, owing to the risk of lymph node metastasis (LNM). However, the rates of LNM in such cases were relatively low (e.g., 8% for EGC). Several recent advances have been made in this field. First, pathological risk stratification for metastatic recurrence following non-curative ER without additional treatment was developed for both superficial ESCC and EGC. Second, the pattern of metastatic recurrence and prognosis after recurrence following non-curative ER without additional treatment was found to be considerably different between superficial ESCC and EGC. Third, a combination of ER and selective chemoradiotherapy was developed as a minimally invasive treatment method for clinical T1b-SM ESCC. These findings may help clinicians decide the treatment strategy for patients following non-curative ER; however, for optimal therapeutic decision-making in such patients, it is also important to predict the prognosis other than SESCC or EGC and impaired quality of life. Thus, a novel algorithm that considers these factors, as well as metastatic recurrence, should be developed.

  83. Suppressed cellular senescence mediated by T-box3 in aged gastric epithelial cells may contribute to aging-related carcinogenesis Peer-reviewed

    Akio Takeuchi, Naoki Asano, Akira Imatani, Masashi Saito, Xiaoyi Jin, Masahiro Saito, Takeshi Kanno, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

    Cancer Research Communications　2022/07/14

    Publisher: American Association for Cancer Research (AACR)

    DOI： 10.1158/2767-9764.crc-22-0084 　

    eISSN： 2767-9764

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    Abstract Aging is a risk factor for cancers in various organs. Recent advances in the organoid culturing system have made it viable to investigate the influence of aging utilizing these mini organs. In this study, we aimed to examine the implications of aging for gastric carcinogenesis. Gastric organoids established from aged mice grew larger, proliferated vigorously, and survived longer than that from young mice. Since Wnt/b-catenin signaling was intensified in the aged organoids and since removal of Wnt-related factors diminished their proliferation, we investigated for Wnt target gene that contributed to enhanced proliferation and discovered that the aged organoids expressed the transcription factor T-box3 (Tbx3), which has been reported to suppress cellular senescence. Indeed, cellular senescence was suppressed in the aged organoids, and this resulted from enhanced G2/M transition. As for the mechanism involved in the intensified Wnt/b-catenin signaling, we identified that Dickkopf3 (Dkk3) expression was reduced in the aged organoids due to methylation of the Dkk3 gene. Finally, the expression of TBX3 was enhanced in human atrophic gastritis and even more enhanced in human gastric cancers. In addition, its expression correlated positively with patients' age. These results indicated that the emergence of anti-senescent property in aged gastric organoids due to enhanced Tbx3 expression led to accelerated cellular proliferation and organoid formation. Since the enhanced Tbx3 expression seen in aged gastric organoids was also observed in human gastric cancer tissues, this Dkk3-Wnt-Tbx3 pathway may be involved in aging-related gastric carcinogenesis.

  84. A Case of Gastric Cancer With a Rare Spreading Pattern Into the Submucosal Layer Peer-reviewed

    Yutaka Hatayama, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Tomoyuki Koike, Atsushi Masamune

    Journal of the Canadian Association of Gastroenterology　2022/04/08

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/jcag/gwac012 　

    ISSN： 2515-2084

    eISSN： 2515-2092

  85. Recent approach for preventing complications in upper gastrointestinal endoscopic submucosal dissection Invited Peer-reviewed

    Waku Hatta, Tomoyuki Koike, Hiroko Abe, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

    DEN Open　2　(1)　2022/04

    Publisher: Wiley

    DOI： 10.1002/deo2.60 　

    ISSN： 2692-4609

    eISSN： 2692-4609

  86. Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia. Peer-reviewed

    Yasuaki Abe, Waku Hatta, Sho Asonuma, Tomoyuki Koike, Hiroko Abe, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Hironobu Sasano, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　2022/02/01

    DOI： 10.2169/internalmedicine.8253-21 　

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    A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase [please check this carefully]. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up.

  87. Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma Peer-reviewed

    Shusuke Toda, Waku Hatta, Kiyotaka Asanuma, Naoki Asano, Yoshitaka Ono, Hiroko Abe, Yohei Ogata, Masahiro Saito, Takeshi Kanno, Xiaoyi Jin, Kaname Uno, Tomoyuki Koike, Akira Imatani, Shin Hamada, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

    The Tohoku Journal of Experimental Medicine　2022

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2022.j077 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  88. Is Additional Gastrectomy Required for Elderly Patients after Endoscopic Submucosal Dissection with Endoscopic Curability C-2 for Early Gastric Cancer? International-journal Peer-reviewed

    Waku Hatta, Takuji Gotoda, Tomoyuki Koike, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

    Digestion　103　(1)　83-91　2022

    DOI： 10.1159/000519514 　

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    BACKGROUND: With the ongoing growth of the aged population, the number of elderly patients suffering from gastric cancer has increased in Japan. Since the frequency of lymph node metastasis (LNM) in patients after endoscopic submucosal dissection (ESD) with endoscopic curability (eCura) C-2 for early gastric cancer (EGC) is relative low, the following question can be raised: "Is additional gastrectomy required for elderly patients with such criteria for ESD?" SUMMARY: For therapeutic decision-making after ESD with eCura C-2, the risk of all-cause mortality and impaired quality of life (QoL) should thus be evaluated. Risk stratification of LNM and gastric cancer-specific mortality was established by the eCura system; however, it remains unclear how much these categories and treatment selection affect all-cause mortality. The contribution of prognostic tools for predicting all-cause mortality was noted to vary across the studies of patients with EGC; thus, further studies that investigate comprehensive geriatric assessment (CGA) may be required. Regarding the QoL, studies on elderly patients remain to be lacking. Furthermore, one of the issues with CGA and QoL tools is that they are time consuming. Key Messages: Combined evaluation of risk stratification of gastric cancer-specific mortality by the eCura system and risk of nongastric cancer-related mortality and impaired QoL may be the current optimal method to decide treatment strategy after ESD with eCura C-2 for EGC among elderly patients. A large-scale prospective study that investigates CGA domains is required to identify predictors of all-cause mortality and impaired QoL, and a more easily usable tool should be developed.

  89. Reply to "Acid suppressants during hospitalization and after discharge in patients after gastroduodenal ESD". Invited Peer-reviewed

    Hiroko Abe, Kunio Tarasawa, Waku Hatta, Kaname Uno, Tomoyuki Koike, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

    Journal of gastroenterology　56　(12)　1109-1110　2021/12

    DOI： 10.1007/s00535-021-01824-w 　

  90. Comparison of Magnifying Endoscopy with Blue Light Imaging and Narrow Band Imaging for Determining the Invasion Depth of Superficial Esophageal Squamous Cell Carcinoma by the Japanese Esophageal Society's Intrapapillary Capillary Loop Classification. International-journal Peer-reviewed

    Waku Hatta, Tomoyuki Koike, Yohei Ogata, Yutaka Kondo, Nobuyuki Ara, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

    Diagnostics (Basel, Switzerland)　11　(11)　2021/10/20

    DOI： 10.3390/diagnostics11111941 　

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    Blue light imaging (BLI) and narrow-band imaging (NBI) are two modalities that enable narrow-band light observation. We aimed to compare the diagnostic ability of magnifying endoscopy with BLI (ME-BLI) and NBI (ME-NBI) for determining the invasion depth of superficial esophageal squamous cell carcinoma (SESCC) by the Japanese Esophageal Society's intrapapillary capillary loop (IPCL) classification. We enrolled 81 patients between 2014 and 2018, and the still endoscopic images for diagnosing the invasion depth at the same part in ME-BLI and ME-NBI were registered. Two blinded investigators reviewed them and diagnosed the invasion depth by the IPCL classification. Subsequently, the diagnostic yields in two modalities were compared. The overall accuracies for the invasion depth by the IPCL classification in ME-BLI and ME-NBI did not differ significantly (67.9-71.6% vs. 72.8-74.1%). In the analysis based on the invasion depth, the sensitivities and positive predictive values in tumors invading the muscularis mucosa or submucosa ≤200 µm were low (23.1-30.8% and 16.7-25.0%, respectively) in both modalities. In conclusion, the diagnostic ability for determining the invasion depth of SESCC by the IPCL classification was relatively similar in ME-BLI and ME-NBI, but diagnosis by magnifying endoscopy alone might not be satisfactory.

  91. Predictors of early and late mortality after the treatment for early gastric cancers. International-journal Peer-reviewed

    Yohei Ogata, Waku Hatta, Yuki Ohara, Tomoyuki Koike, Hiroko Abe, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Akihiro Yamamura, Naoki Tanaka, Takashi Kamei, Michiaki Unno, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　2021/10/18

    DOI： 10.1111/den.14172 　

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    OBJECTIVES: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately. METHODS: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of 3 years. RESULTS: We enrolled 1439 patients with a median follow-up period of 79 months. The 5-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥85 years (hazard ratio [HR] 2.88 and 4.54, respectively) and Eastern Cooperative Oncology Group Performance Status ≥2 (HR 3.00 and 4.19, respectively). Charlson comorbidity index ≥2 (HR 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥3 (HR 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥0.028 (HR 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR 2.26), intermediate- (HR 2.12)/high-risk (HR 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR 1.70) were predictors for early mortality. CONCLUSION: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality.

  92. A rare case of penetration related to ischemic duodenitis after ventricular assist device implantation for dilated cardiomyopathy. Peer-reviewed

    Hiroko Abe, Kaname Uno, Naoki Tanaka, Masamichi Mizuma, Waku Hatta, Naoki Asano, Tomoyuki Koike, Akira Imatani, Michiaki Unno, Atsushi Masamune

    Clinical journal of gastroenterology　14　(4)　1186-1190　2021/08

    DOI： 10.1007/s12328-021-01346-1 　

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    A 66-year-old man with a history of diabetes and dilated cardiomyopathy underwent the implantation of a ventricular assist device (VAD) at the age of 62. He suffered from epigastralgia for a month and then visited our hospital with complaints of severe epigastralgia and hematemesis. A physical examination revealed abdominal distension without rigidity. Laboratory data showed severe systemic inflammation, multiple organ failure, and disseminated intravascular coagulation. Computed tomography showed multifocal thickness of the gastroduodenal wall with surrounding panniculitis, gas in a portal vein and a perigastric vein. Emergency esophago-gastro duodenoscopy (EGD) demonstrated a large erosion in the antrum of the stomach, and penetration surrounded by circumferentially ischemic mucosa in the second and third portions of the duodenum. Based on informed consent, conservative therapy was performed, and his condition improved enabling the start of oral intake on the 37th hospital day. However, 7 days later, there was a relapse of epigastralgia after a meal. Gastrointestinal series and EGD revealed a 10-mm-long pinhole-like stricture at the site. After laparoscopic gastro-jejunal bypass surgery, he has remained in a good condition for 2 years. We demonstrated a rare case of penetration due to severe ischemic duodenitis 4 years after VAD implantation.

  93. Prevention of delayed bleeding with vonoprazan in upper gastrointestinal endoscopic treatment. Peer-reviewed

    Hiroko Abe, Waku Hatta, Yohei Ogata, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Kunio Tarasawa, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

    Journal of gastroenterology　56　(7)　640-650　2021/07

    DOI： 10.1007/s00535-021-01781-4 　

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    BACKGROUND: Delayed bleeding is the major adverse event in upper gastrointestinal endoscopic treatment (UGET). We aimed to investigate the efficacy of vonoprazan, which is the novel strong antisecretory agent, to reduce the risk for delayed bleeding in comparison with proton pump inhibitors (PPIs) in UGET. METHODS: This retrospective population-based cohort study used the Diagnosis Procedure Combination database in Japan. We included patients on vonoprazan or PPI in UGET between 2014 and 2019. The primary outcome was delayed bleeding. We conducted propensity score matching to balance the comparison groups, and logistic regression analyses to compare the bleeding outcomes. RESULTS: We enrolled 124,422 patients, in which 34,822 and 89,600 were prescribed with vonoprazan and PPI, respectively. After propensity score matching, the risk for delayed bleeding was lower in vonoprazan than in PPI (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.71-0.80), consistent with sensitivity analysis results. In the subgroup analyses of seven UGET procedures, vonoprazan was significantly advantageous in esophageal endoscopic submucosal dissection (E-ESD) (OR, 0.71; 95% CI, 0.54-0.94) and gastroduodenal endoscopic submucosal dissection (GD-ESD) (OR, 0.70; 95% CI, 0.65-0.75), although correction for multiple testing of the outcome data removed the significance in E-ESD. These results were also consistent with sensitivity analysis results. In the five other procedures, no significant advantage was found. CONCLUSIONS: This nationwide study found that, compared with PPI, vonoprazan can reduce delayed bleeding with approximately 30% in GD-ESD. Vonoprazan has the possibility to become a new treatment method for preventing delayed bleeding in this procedure.

  94. A Rare Case of Localized Esophageal Amyloidosis. Peer-reviewed

    Taku Fujiya, Waku Hatta, Tomoyuki Koike, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Nagaaki Katoh, Tsuneaki Yoshinaga, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　60　(10)　1529-1532　2021/05/15

    DOI： 10.2169/internalmedicine.6321-20 　

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    A 72-year-old man without any symptoms was referred to our hospital. Esophagogastroduodenoscopy revealed an elevated esophageal lesion that was covered with normal mucosa. The examination of biopsy specimens from the lesion revealed amyloid light-chain (AL) (λ) type amyloid deposits, but there were no amyloid deposits elsewhere in the gastrointestinal tract. Further examinations did not indicate systemic amyloidosis. Thus, this case was diagnosed as a localized esophageal amyloidosis. As the clinical outcome of localized amyloidosis is favorable, this case was scheduled for close follow-up. Localized amyloidosis should be considered in the differential diagnosis of esophageal submucosal tumors.

  95. 新規内視鏡シミュレーターを用いた、消化管止血術学習プログラムによる教育介入研究

    畑山 裕, 菅野 武, 齊藤 真弘, 中川 健一郎, 金 笑奕, 八田 和久, 宇野 要, 浅野 直喜, 今谷 晃, 小池 智幸, 正宗 淳

    日本消化器病学会雑誌　118　(臨増総会)　A329-A329　2021/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  96. 歯周病菌リポ多糖類刺激によるピロリ菌除菌療法後の胃粘膜バリア傷害の検討

    織内 優好, 宇野 要, 李 秀載, 齊藤 真弘, 中川 健一郎, 金 笑奕, 菅野 武, 八田 和久, 浅野 直喜, 小池 智幸, 今谷 晃, 正宗 淳

    日本消化器病学会雑誌　118　(臨増総会)　A332-A332　2021/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  97. 新規内視鏡シミュレーターを用いた、消化管止血術学習プログラムによる教育介入研究

    畑山 裕, 菅野 武, 齊藤 真弘, 中川 健一郎, 金 笑奕, 八田 和久, 宇野 要, 浅野 直喜, 今谷 晃, 小池 智幸, 正宗 淳

    日本消化器病学会雑誌　118　(臨増総会)　A329-A329　2021/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  98. 【Barrett食道腺癌の内視鏡診断と治療2021】Barrett食道腺癌のsurveillance LSBEを中心に

    小池 智幸, 齊藤 真弘, 大原 祐樹, 伊丹 英昭, 外田 修裕, 竹内 章夫, 大方 智樹, 李 秀載, 中川 健一郎, 金 笑奕, 菅野 武, 八田 和久, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    胃と腸　56　(2)　163-173　2021/02

    Publisher: (株)医学書院

    ISSN： 0536-2180

    eISSN： 1882-1219

  99. Linked-color Imaging May Help Improve the Visibility of Superficial Barrett's Esophageal Adenocarcinoma by Increasing the Color Difference. Peer-reviewed

    Masahiro Saito, Tomoyuki Koike, Yuki Ohara, Kenichiro Nakagawa, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　60　(21)　3351-3358　2021

    DOI： 10.2169/internalmedicine.6674-20 　

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    Objective Linked-color imaging (LCI), a new technology for image-enhanced endoscopy, emphasizes the color of the mucosa, and its practicality in the detection of early gastric and colon cancers has been reported. However, whether or not LCI is useful for the diagnosis of Barrett's adenocarcinoma (BA) has been unclear. In this study, we explored whether or not LCI enhances the color difference between a BA lesion and the surrounding mucosa. Methods Twenty-one lesions from 20 consecutive patients with superficial BA who underwent endoscopic submucosal dissection between November 2014 and September 2017 were retrospectively examined. The color differences (ΔE*) between the inside and outside of the lesion were evaluated retrospectively using white-light imaging (WLI), blue-light imaging (BLI), and LCI objectively, based on a Commission Internationale de l'Eclairage (CIE) lab color system. Furthermore, we compared the morphology, color, and circumferential location of the lesion. Results The median values of the color difference (ΔE*) in WLI and BLI were 9.1 and 5.8, respectively, and no difference was observed. In LCI, the median color difference was 17.6, which was higher than that of WLI and BLI. Regardless of the morphology, color, and circumferential location of BA lesions, the color difference was larger in LCI than in WLI. Conclusion LCI increases the color difference between the BA and the surrounding Barrett's mucosa.

  100. The Ameliorating Effect of Switching to Vonoprazan: A Novel Potassium-Competitive Acid Blocker in Patients with Proton Pump Inhibitor Refractory Non-Erosive Reflux Disease. International-journal Peer-reviewed

    Yasuaki Abe, Tomoyuki Koike, Masahiro Saito, Tomoki Okata, Kenichiro Nakagawa, Waku Hatta, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

    Digestion　102　(3)　480-488　2021

    DOI： 10.1159/000506152 　

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    INTRODUCTION: Weakly acidic reflux has been reported to be the major cause of symptoms in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) undergoing PPI treatment. We previously reported that reflux at pH 4-5 was the main factor that induced symptoms in such patients. The present study aimed to elucidate the symptom-ameliorating effect of vonoprazan (VPZ) by evaluating the change in the pH value of the refluxate using multichannel intraluminal impedance and pH (MII-pH) monitoring. METHODS: We retrospectively evaluated the records of MII-pH monitoring in 29 symptom index (SI) and/or symptom association probability (SAP)-positive patients with PPI-refractory NERD. After switching to VPZ 20 mg/day, we performed MII-pH monitoring again. We assessed the change in the score of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), the pH value of the refluxate, and the percent times of intragastric pH <4 or <5 before and after switching. We divided the patients into the following 2 groups according to the FSSG score after switching: effective and noneffective groups. RESULTS: Among of the 29 SI/SAP-positive patients, 16 underwent switching to VPZ. Furthermore, of these 16 patients, 10 underwent MII-pH monitoring again after switching. The FSSG score decreased, the pH value of the refluxate increased, and the percent times of intragastric pH <4 or <5 reduced after switching when compared with the findings before switching. In the effective group, both the proportion of reflux at pH <4 and that of reflux at pH 4-5 decreased while taking VPZ when compared with the findings while taking double-dose PPI. In the noneffective group, the proportion of reflux at pH <4 decreased but that of reflux at pH 4-5 increased and that of reflux at pH <5 did not change overall while taking VPZ. In addition, the percent times of intragastric pH <5 values were low in the effective group. CONCLUSION: Symptom suppression appears to be inadequate in patients with persistent reflux at pH 4-5 even with VPZ 20 mg/day. Strong acid suppressive therapy with VPZ to increase the pH value of the refluxate to ≥5 is useful for symptom improvement.

  101. Predictors of Early and Late Mortality after Endoscopic Resection for Esophageal Squamous Cell Carcinoma. Peer-reviewed

    Yohei Ogata, Waku Hatta, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

    The Tohoku journal of experimental medicine　253　(1)　29-39　2021/01

    DOI： 10.1620/tjem.253.29 　

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    In esophageal squamous cell carcinoma (ESCC) comprising 90% of cases with esophageal cancer, endoscopic resection (ER) is recommended for patients with negligible risk of ESCC-related mortality. In fact, a main cause of death in patients underwent ER is not ESCC. We thus aimed to clarify the predictors for early and late mortality among patients underwent ER of ESCC between 2005 and 2018 at our institution. In this retrospective cohort study, we investigated the prognosis and predictors of early and late mortality with the cut-off value of 3 years. We enrolled 407 patients with a median 69 months follow-up. The 5-year overall survival and disease-specific survival, an indicator of ESCC-related mortality, were 83.4% and 98.4%, respectively. In multivariate Cox analyses, Eastern Cooperative Oncology Group performance status (ECOG-PS), consisting of six grades by a patient's level of activity, ≥ 2 was a predictor for early and late morality [hazard ratio (HR), 7.21 (P = 0.007) and 15.62 (P = 0.021), respectively]. Charlson comorbidity index (CCI), which is an index for predicting mortality by comorbid conditions, ≥ 2 was also a predictor for both mortality [HR, 2.97 (P = 0.017) and 1.90 (P = 0.019), respectively]. However, age was a predictor only for late mortality [HR, 3.08 (P = 0.010) in 80-84 years and 8.38 (P < 0.001) in ≥ 85 years]. Considering the predictive ability for early mortality, we propose that ECOG-PS and/or CCI are better indices compared with age in deciding treatment strategy after ER for ESCC.

  102. A Case of the Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis Peer-reviewed

    Masahiro Saito, Tomoyuki Koike, Yasuaki Abe, Kenichiro Nakagawa, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Atsushi Masamune

    Internal Medicine　2021

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.5431-20 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  103. Localized Gastric Amyloidosis that Displayed Morphological Changes over 10 Years of Observation Peer-reviewed

    Yasushi Takahashi, Waku Hatta, Tomoyuki Koike, Yohei Ogata, Taku Fujiya, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Nagaaki Katoh, Tsuneaki Yoshinaga, Atsushi Masamune

    Internal Medicine　2021

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.5031-20 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  104. A rare case of gastric squamous-cell carcinoma metastasized from the cervix. Peer-reviewed

    Masayoshi Oriuchi, Kaname Uno, Fumiyoshi Fujishima, Akio Takeuchi, Sujae Lee, Waku Hatta, Naoki Asano, Tomoyuki Koike, Akira Imatani, Atushi Masamune

    Clinical journal of gastroenterology　13　(6)　1062-1065　2020/12

    DOI： 10.1007/s12328-020-01191-8 　

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    Gastric squamous-cell carcinoma (SqCC) metastasized form the cervix is rarely detected in endoscopic examination, although cervical carcinoma is the second most common in gynecologic malignancy. A 59-year-old female visited a clinic for anorexia, and an esophago-gastro-duodenoscopy (EGD) revealed multiple submucosal tumors (SMTs) of the stomach. After she was referred, an image-enhanced endoscopy enhanced multiple SMTs with white spots, whose findings were irregular micro-vascular patterns in the mucosa with irregular/absent micro-surface pattern. We took endoscopic biopsies, whose histological diagnoses were SqCC in the layer of the lamina propria under normal epithelium. Positron emission tomography-CT, CT and magnetic resonance imaging revealed an irregularly enhanced mass of the cervix, the irregularly thickening wall of the stomach and peritoneal nodules. Palliative care alone was administered based on poor condition associated with the Stage IV cervical carcinoma. In this case, endoscopic detection of gastric SqCC might provide a tip to make final diagnosis of primary site of cervical SqCC. The numbers of endoscopic examination become increasing, so further deep awareness of such patterns of metastasis in cervical cancer are required.

  105. Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease. International-journal Peer-reviewed

    Kazuaki Norita, Kiyotaka Asanuma, Tomoyuki Koike, Tomoki Okata, Taku Fujiya, Yasuaki Abe, Kenichiro Nakagawa, Waku Hatta, Kaname Uno, Tomohiro Nakamura, Naoki Nakaya, Naoki Asano, Akira Imatani, Tooru Shimosegawa, Atsushi Masamune

    Digestion　1-11　2020/08/12

    DOI： 10.1159/000508661 　

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    BACKGROUND AND OBJECTIVE: Weakly acidic reflux reaching to the proximal esophagus is closely related to the perception of gastroesophageal reflux in patients with nonerosive reflux disease despite treatment with a proton pump inhibitor (PPI). However, little is known about the involvement of the patients' mucosal integrity of the proximal esophagus. METHODS: We recruited 15 symptomatic nonerosive gastroesophageal reflux disease (GERD) patients with a positive symptom index despite PPI treatment and 11 healthy asymptomatic volunteers as controls. The biopsy specimens obtained from the proximal and distal esophagus were applied to a mini-Ussing chamber system to measure transepithelial electrical resistance (TEER) against a pH 4 weak acid. The esophageal biopsy samples were subjected to quantitative real-time PCR and immunohistochemical analysis. RESULTS: In the proximal esophagus, the weak acid exposure reduced the TEER in the PPI-refractory patients compared to that in the controls. The frequency of the reflux extending to the proximal esophagus had a significant correlation with the reduction in the proximal esophageal TEER in the patients. The reduced TEER in the proximal esophagus was accompanied by an increase in IL-8 and IL-1β mRNA and a decrease in occludin mRNA levels. The proximal esophageal mucosa in the patients presented infiltration of CD3-positive lymphocytes and an increased expression of solute carrier organic anion transporter family member 2A1 (SLCO2A1), a passage gate of reflux symptom-evoking molecules. CONCLUSIONS: The reflux perception is related to an impairment of the proximal esophageal mucosal integrity in patients with nonerosive reflux disease despite PPI.

  106. Sox2 induces tumorigenesis and angiogenesis of early stage esophagealsquamous cell carcinoma through secretion of Suprabasin. International-journal Peer-reviewed

    Kiichi Takahashi, Naoki Asano, Akira Imatani, Yutaka Kondo, Masashi Saito, Akio Takeuchi, Xiaoyi Jin, Masahiro Saito, Waku Hatta, Kiyotaka Asanuma, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

    Carcinogenesis　2020/02/14

    DOI： 10.1093/carcin/bgaa014 　

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    Early stage of esophageal squamous cell carcinoma (ESCC) is known to be accompanied by angiogenesis and morphological changes of microvessels. Transcription factor Sox2 is amplified in various cancers including ESCC, but the role of Sox2 in the carcinogenesis and angiogenesis has not been determined. Hence, we aimed to investigate the role of Sox2 in the early stage of ESCC. We found that the expression of Sox2 was significantly higher in early stage ESCC tissues than that in their adjacent normal tissues. We then established Sox2-inducible normal human esophageal squamous cell line (HetSox2) to investigate the role of Sox2 in esophageal carcinogenesis and angiogenesis in vitro. Sox2 overexpression led to increased cell proliferation and spheroid formation. The culture supernatant of Sox2-overexpressing HetSox2 induced migration and sprouting of endothelial cell line HUVEC. As for the mechanism, we found that the expression of secreted protein Suprabasin was directly induced by Sox2. Suprabasin enhanced proliferation of normal human esophageal squamous cells and HUVEC when added to the culture. Moreover, Suprabasin enhanced migration and sprouting of HUVEC cells, which were observed with the culture supernatant of Sox2-oversxpressing HetSox2. This angiogenic effect of Suprabasin was abolished by inhibiting AKT phosphorylation, which suggested its dependence on AKT signaling. Finally, we showed that Suprabasin expression and the density of microvessels were significantly higher in ESCC tissues with high Sox2 expression. Our study suggested that increased Sox2 expression in esophageal squamous cells induced Suprabasin expression, and as a result initiated the carcinogenesis via increased cell proliferation and angiogenesis.

  107. Gastric Duplication Cyst With Occult GIST Component. International-journal Peer-reviewed

    Sujae Lee, Kaname Uno, Fumiyoshi Fujishima, Waku Hatta, Tomoyuki Koike, Takeshi Aoki, Naoki Tanaka, Hiroaki Musha, Ryosuke Kikuchi, Atsushi Masamune

    ACG case reports journal　7　(2)　e00260　2020/02

    DOI： 10.14309/crj.0000000000000260 　

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    A 37-year-old man underwent screening examinations, and a pale-colored submucosal tumor was detected on gastric cardia. Endosonography showed a 15-mm cyst with hypoechoic nodules in the muscularis propria, and endoscopic ultrasound-guided fine-needle aspiration obtained mucinous fluid with atypical spindle cells positive for c-kit, indicating a gastrointestinal stromal tumor. Surgical resection was recommended, but he initially agreed to surveillance. After becoming larger for 8 years, partial gastrectomy was performed for the 22 × 22 × 15-mm capsulized lesion. Surprisingly, its histology was gastric duplication cyst without gastrointestinal stromal tumor. Gastric duplication cyst is a rare entity with the possibility of malignant complications, but careful assessment of endoscopic ultrasound-guided fine-needle aspiration might also be required.

  108. A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component. Peer-reviewed

    Takeuchi A, Hatta W, Koike T, Saito M, Jin X, Asanuma K, Uno K, Asano N, Imatani A, Fujishima F, Masamune A

    Internal medicine (Tokyo, Japan)　58　(17)　2467-2472　2019/09

    DOI： 10.2169/internalmedicine.2722-19 　

    ISSN： 0918-2918

  109. Difficult Preoperative Diagnosis of Lymphoepithelioma-Like Carcinoma of the Esophagus. Peer-reviewed

    Okata T, Uno K, Fujishima F, Saito M, Jin X, Hatta W, Asanuma K, Asano N, Koike T, Imatani A, Masamune A

    ACG Case Rep J　2019/08

  110. Strong Intra-Esophageal Reflux May Contribute to the Development of Barrett's Adenocarcinoma and Affect the Localization. Peer-reviewed

    Saito M, Koike T, Nakagawa K, Abe Y, Norita K, Kikuchi H, Kanno T, Hatta W, Ara N, Uno K, Asanuma K, Asano N, Imatani A, Shimosegawa T, Masamune A

    Digestion　1-9　2019/08

    DOI： 10.1159/000502377 　

    ISSN： 0012-2823

  111. Influence of the pH Value of Refluxate and Proximal Extent on Heartburn Perception in Patients with Proton Pump Inhibitor-Refractory Non-Erosive Reflux Disease. Peer-reviewed

    Abe Y, Koike T, Saito M, Okata T, Norita K, Kikuchi H, Nakagawa K, Hatta W, Asanuma K, Uno K, Asano N, Imatani A, Shimosegawa T, Masamune A

    Digestion　1-7　2019/07

    DOI： 10.1159/000500133 　

    ISSN： 0012-2823

  112. Continuously liquid-sucking catheter attachment for the endoscope reduces the volume of liquid reflux to the mouth in esophageal endoscopic submucosal dissection. Peer-reviewed

    Hatta W, Koike T, Okata H, Hanzawa T, Saito M, Kondo Y, Ara N, Asanuma K, Uno K, Asano N, Imatani A, Iijima K, Nakamura T, Nakaya N, Masamune A

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　2019/03

    DOI： 10.1111/den.13392 　

    ISSN： 0915-5635

  113. Endoscopic Findings of Esophageal Adenosquamous Carcinoma Diagnosed by Endoscopic Mucosal Resection. Peer-reviewed

    Endo H, Koike T, Hatta W, Asanuma K, Uno K, Asano N, Imatani A, Watanabe M, Kato K, Masamune A

    Case reports in gastroenterology　13　(1)　144-152　2019/01

    DOI： 10.1159/000499182 　

  114. Management of aorto-esophageal fistula secondary after thoracic endovascular aortic repair: a review of literature Peer-reviewed

    Kaname Uno, Tomoyuki Koike, Seiichi Takahashi, Daisuke Komazawa, Tooru Shimosegawa

    Clinical Journal of Gastroenterology　10　(5)　393-402　2017/10/01

    Publisher: Springer Tokyo

    DOI： 10.1007/s12328-017-0762-z 　

    ISSN： 1865-7265 1865-7257

  115. Risk of metachronous recurrence after endoscopic submucosal dissection of esophageal squamous cell carcinoma Peer-reviewed

    K. Uno, T. Koike, G. Kusaka, Y. Takahashi, N. Ara, T. Shimosegawa

    DISEASES OF THE ESOPHAGUS　30　(6)　2017/06

    DOI： 10.1093/dote/dox005 　

    ISSN： 1442-2050

  116. ENDOSCOPIC FINDINGS FOR PREDICTING GASTRIC ACID SECRETION STATUS Peer-reviewed

    HATTA Waku, SHIMOSEGAWA Tooru, IIJIMA Katsunori, KOIKE Tomoyuki, KONDO Yutaka, ARA Nobuyuki, ASANUMA Kiyotaka, UNO Kaname, ASANO Naoki, IMATANI Akira

    GASTROENTEROLOGICAL ENDOSCOPY　58　(10)　2222-2231　2016/10

    Publisher: 一般社団法人 日本消化器内視鏡学会

    ISSN： 0387-1207

    More details Close

    &lt;p&gt;Background and Aim : Gastric acidic abnormalities are related to various types of diseases in &lt;i&gt;Helicobacter pylori&lt;/i&gt; (&lt;i&gt;H. pylori&lt;/i&gt;) infection status. However, no studies have shown correlations between many tiny endoscopic findings and the acid secretion level simultaneously. In the present study, we investigated predictive tiny endoscopic findings of hyperchlorhydria and hypochlorhydria.&lt;/p&gt;&lt;p&gt;Methods : A total of 223 subjects without organic diseases who underwent esophagogastroduodenoscopy and endoscopic gastrin test (EGT) for estimating gastrin-stimulated gastric acid secretory response between 1999 and 2012 at our institution were retrospectively analyzed. Two blinded expert endoscopists reviewed the images independently and recorded the endoscopic findings.&lt;/p&gt;&lt;p&gt;Results : According to the EGT values, the enrolled subjects were categorized into hyperchlorhydria, normal acid secretion, and hypochlorhydria groups. In all subjects, hematin (odds ratio [95% confidence interval] = 3.32 [1.40-7.84]) and antral erosion (2.88 [1.24-6.70]) were the predictive endoscopic findings for hyperchlorhydria, and swelling of areae gastricae (14.4 [5.74-36.1]) and open-type atrophy (15.1 [7.35-31.1]) were those for hypochlorhydria. In addition, the predictive endoscopic findings for hyperchlorhydria differed according to the &lt;i&gt;H. pylori&lt;/i&gt; infection status, hematin in &lt;i&gt;H. pylori&lt;/i&gt;-positive subjects and antral erosion in &lt;i&gt;H. pylori&lt;/i&gt;-negative subjects, in contrast to those for hypochlorhydria, which were the same irrespective of the &lt;i&gt;H. pylori&lt;/i&gt; infection status.&lt;/p&gt;&lt;p&gt;Conclusions : We could predict the acid secretion status based on the endoscopic findings regardless of &lt;i&gt;H. pylori&lt;/i&gt; infection status, which would be of some help for evaluating the risk for acid-related diseases.&lt;/p&gt;

  117. Usefulness of Endoscopic Imaging to Visualize Regional Alterations in Acid Secretion of Noncancerous Gastric Mucosa after Helicobacter pylori Eradication Peer-reviewed

    Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Yasushi Takahashi, Nobuyuki Ara, Tooru Shimosegawa

    JOURNAL OF GASTRIC CANCER　16　(3)　152-160　2016/09

    DOI： 10.5230/jgc.2016.16.3.152 　

    ISSN： 2093-582X

    eISSN： 2093-5641

  118. PROSPECTIVE ANALYSIS OF RISK FOR BLEEDING AFTER ENDOSCOPIC BIOPSY WITHOUT CESSATION OF ANTITHROMBOTICS IN JAPAN Peer-reviewed

    ARA Nobuyuki, IMATANI Akira, SHIMOSEGAWA Tooru, IIJIMA Katsunori, MAEJIMA Ryuhei, KONDO Yutaka, KUSAKA Gen, HATTA Waku, UNO Kaname, ASANO Naoki, KOIKE Tomoyuki

    GASTROENTEROLOGICAL ENDOSCOPY　58　(8)　1367-1374　2016/08

    Publisher: 一般社団法人 日本消化器内視鏡学会

    ISSN： 0387-1207

    More details Close

    Background and Aim : In Japan, after the revision of the gastrointestinal endoscopic guidelines for patients taking antithrombotics, endoscopic biopsies were permitted while continuing antithrombotic treatment. However, the risk of bleeding after the biopsy with or without cessation of antithrombotics has not been fully evaluated because bleeding events are very rare. The aim of this prospective study was to evaluate the risk for bleeding after upper gastrointestinal biopsy without cessation of antithrombotics.&lt;BR&gt;Methods : Consecutive patients who underwent upper gastrointestinal endoscopic biopsy from December 2011 to March 2014 were enrolled in this study. Antithrombotic medication and its cessation status was checked at enrollment. To confirm bleeding events associated with biopsy, medical examination at the hospital or direct confirmation by telephone was done within 1 month after the biopsy.&lt;BR&gt;Results : Among the 3758 patients who underwent endoscopic biopsies, 394 patients (10.5%) were medicated with antithrombotics, and 286 of them (72.6% of the total antithrombotics users) did not undergo cessation. Bleeding after the biopsy occurred in six cases (0.15%, 95% CI ; 0.09%&amp;sim;0.22%), but there was only one case that had continued taking antithrombotics. The incidence of bleeding after biopsy was not significantly higher in the patients who had continued taking antithrombotics compared with the others (0.35% vs 0.14%, &lt;I&gt;P&lt;/I&gt; = 0.38).&lt;BR&gt;Conclusion : This prospective study showed that continuation of antithrombotics did not increase the bleeding risk after upper gastrointestinal endoscopic biopsy.

  119. Feasibility of optical coherence tomography for the evaluation of Barrett's mucosa buried underneath esophageal squamous epithelium Peer-reviewed

    Waku Hatta, Kaname Uno, Tomoyuki Koike, Nobuyuki Ara, Naoki Asano, Katsunori Iijima, Akira Imatani, Fumiyoshi Fujishima, Tooru Shimosegawa

    DIGESTIVE ENDOSCOPY　28　(4)　427-433　2016/05

    DOI： 10.1111/den.12576 　

    ISSN： 0915-5635

    eISSN： 1443-1661

  120. A Japanese case of lymphocytic esophagitis Peer-reviewed

    Ryuhei Maejima, Kaname Uno, Katsunori Iijima, Fumiyoshi Fujishima, Tetsuya Noguchi, Nobuyuki Ara, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

    DIGESTIVE ENDOSCOPY　28　(4)　476-480　2016/05

    DOI： 10.1111/den.12578 　

    ISSN： 0915-5635

    eISSN： 1443-1661

  121. Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses Peer-reviewed

    Naoki Asano, Akira Imatani, Tomohiro Watanabe, Jun Fushiya, Yutaka Kondo, Xiaoyi Jin, Nobuyuki Ara, Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Warren Strober, Tooru Shimosegawa

    CANCER RESEARCH　76　(5)　1135-1145　2016/03

    DOI： 10.1158/0008-5472.CAN-15-2272 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  122. Gastric cancer development after the successful eradication of Helicobacter pylori Peer-reviewed

    Kaname Uno, Katsunori Iijima, Tooru Shimosegawa

    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY　8　(3)　271-281　2016/03

    DOI： 10.4251/wjgo.v8.i3.271 　

    ISSN： 1948-5204

  123. Usefulness of Optical Coherence Tomography Diagnosis for Superficial Esophageal Cancer Invited Peer-reviewed

    Uno K., Koike T., Shimosegawa T.

    Nihon Kikan Shokudoka Gakkai Kaiho　67　(2)　65-65　2016

    Publisher: The Japan Broncho-esophagological Society

    DOI： 10.2468/jbes.67.65 　

    ISSN： 0029-0645

  124. Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients Peer-reviewed

    Kenichiro Nakagawa, Tomoyuki Koike, Katsunori Iijima, Masahiro Saito, Hiroki Kikuchi, Waku Hatta, Nobuyuki Ara, Kaname Uno, Naoki Asano, Tooru Shimosegawa

    WORLD JOURNAL OF GASTROENTEROLOGY　21　(47)　13352-13359　2015/12

    DOI： 10.3748/wjg.v21.i47.13352 　

    ISSN： 1007-9327

    eISSN： 2219-2840

  125. 食道ESDにおける内視鏡外付け持続吸引カテーテルの開発

    八田 和久, 飯島 克則, 榛澤 崇, 荒 誠之, 淺沼 清孝, 宇野 要, 浅野 直喜, 小池 智幸, 今谷 晃, 下瀬川 徹

    Gastroenterological Endoscopy　57　(Suppl.2)　2119-2119　2015/09

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  126. Endoscopic findings for predicting gastric acid secretion status Peer-reviewed

    Waku Hatta, Katsunori Iijima, Tomoyuki Koike, Yutaka Kondo, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Tooru Shimosegawa

    DIGESTIVE ENDOSCOPY　27　(5)　582-589　2015/07

    DOI： 10.1111/den.12427 　

    ISSN： 0915-5635

    eISSN： 1443-1661

  127. 東北大学病院における経皮的内視鏡的胃瘻造設術(PEG)の動向と合併症の検討

    前嶋 隆平, 荒 誠之, 小池 智 幸, 遠藤 博之, 宇野 要, 浅野 直喜, 飯島 克則, 今谷 晃, 下瀬川 徹

    在宅医療と内視鏡治療　17　(1)　3-7　2013/09

  128. Collagenous gastritis Peer-reviewed

    Xiaoyi Jin, Tomoyuki Koike, Takashi Chiba, Yutaka Kondo, Nobuyuki Ara, Kaname Uno, Naoki Asano, Katsunori Iijima, Akira Imatani, Mika Watanabe, Akio Shirane, Tooru Shimosegawa

    Digestive Endoscopy　25　(5)　547-549　2013/09

    DOI： 10.1111/j.1443-1661.2012.01391.x 　

    ISSN： 0915-5635 1443-1661

  129. Gastric hypochlorhydria is associated with an exacerbation of dyspeptic symptoms in female patients Peer-reviewed

    Wataru Iwai, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Naoki Asano, Akira Imatani, Tooru Shimosegawa

    Journal of Gastroenterology　48　(2)　214-221　2013/02

    DOI： 10.1007/s00535-012-0634-8 　

    ISSN： 0944-1174 1435-5922

  130. Biphasic effects of H. pylori infection on low-dose aspirin-induced gastropathy depending on the gastric acid secretion level Peer-reviewed

    Katsunori Iijima, Nobuyuki Ara, Yasuhiko Abe, Tomoyuki Koike, Toshimitsu Iwabuchi, Hirohiko Shinkai, Kaname Uno, Hiroyuki Endo, Naoki Asano, Tooru Shimosegawa

    JOURNAL OF GASTROENTEROLOGY　47　(12)　1290-1297　2012/12

    DOI： 10.1007/s00535-012-0598-8 　

    ISSN： 0944-1174

  131. A Pilot Study of Scheduled Endoscopic Balloon Dilation With Oral Agent Tranilast to Improve the Efficacy of Stricture Dilation After Endoscopic Submucosal Dissection of the Esophagus Peer-reviewed

    Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Yatsuhiko Abe, Naoki Asano, Nobuyuki Ara, Tooru Shimosegawa

    JOURNAL OF CLINICAL GASTROENTEROLOGY　46　(9)　E76-E82　2012/10

    DOI： 10.1097/MCG.0b013e31824fff76 　

    ISSN： 0192-0790

  132. Endoscopic Submucosal Dissection Combined With Endoscopic Injection Sclerotherapy for Early Gastric Cancer on Gastric Fundal Varices Peer-reviewed

    Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Yasuhiko Abe, Naoki Asano, Satoshi Yokosawa, Akira Imatani, Tooru Shimosegawa

    SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES　22　(4)　E226-E229　2012/08

    DOI： 10.1097/SLE.0b013e318254d630 　

    ISSN： 1530-4515

  133. Gastric Cancers Emerging after H. pylori Eradication Arise Exclusively from Non-Acid-Secreting Areas Peer-reviewed

    Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Kaname Uno, Hiroyuki Endo, Waku Hatta, Naoki Asano, Kiyotaka Asanuma, Akira Imatani, Tooru Shimosegawa

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　226　(1)　45-53　2012/01

    DOI： 10.1620/tjem.226.45 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  134. A case of severe esophageal intramural pseudodiverticulosis whose symptoms were ameliorated by oral administration of anti-fungal medicine Peer-reviewed

    Takashi Chiba, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Naoki Asano, Tooru Shimosegawa

    Case Reports in Gastroenterology　6　(1)　103-110　2012/01

    DOI： 10.1159/000336846 　

    ISSN： 1662-0631

  135. Signet ring cell gastric cancer occurring after radiation therapy for helicobacter pylori-uninfected mucosa-associated lymphoid tissue lymphoma Peer-reviewed

    Naoki Asano, Katsunori Iijima, Shiho Terai, Kaname Uno, Hiroyuki Endo, Tomoyuki Koike, Wataru Iwai, Toshimitsu Iwabuchi, Waku Hatta, Yasuhiko Abe, Akira Imatani, Tooru Shimosegawa

    Case Reports in Gastroenterology　5　(2)　325-329　2011/05

    DOI： 10.1159/000329559 　

    ISSN： 1662-0631

  136. A Japanese case series of 12 patients with esophageal eosinophilia Peer-reviewed

    Yasuhiko Abe, Katsunori Iijima, Shuichi Ohara, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Naoki Asano, Akira Imatani, Katsuaki Kato, Daisuke Shibuya, Tooru Shimosegawa

    JOURNAL OF GASTROENTEROLOGY　46　(1)　25-30　2011/01

    DOI： 10.1007/s00535-010-0295-4 　

    ISSN： 0944-1174

  137. Low Serum Levels of Pepsinogen and Gastrin 17 Are Predictive of Extensive Gastric Atrophy with High-Risk of Early Gastric Cancer Peer-reviewed

    Ryousuke Kikuchi, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Kiyotaka Asanuma, Naoki Asano, Akira Imatani, Tooru Shimosegawa

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　223　(1)　35-44　2011/01

    DOI： 10.1620/tjem.223.35 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  138. Exogenous luminal nitric oxide exposure accelerates columnar transformation of rat esophagus Peer-reviewed

    Hiroyuki Endo, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Hirotaka Ito, Naoki Asano, Kaname Uno, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

    INTERNATIONAL JOURNAL OF CANCER　127　(9)　2009-2019　2010/11

    DOI： 10.1002/ijc.25227 　

    ISSN： 0020-7136

    eISSN： 1097-0215

  139. Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria Peer-reviewed

    Tomoyuki Oikawa, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Toru Horii, Wataru Iwai, Yasuhiko Abe, Naoki Asano, Akira Imatani, Tooru Shimosegawa

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY　45　(11)　1338-1344　2010/11

    DOI： 10.3109/00365521.2010.495419 　

    ISSN： 0036-5521

  140. 超・拡大内視鏡の新展開 細胞観察と分子イメージングの現在と未来 食道病変におけるOCT(optical coherence tomography)の有用性

    八田 和久, 宇野 要, 小池 智幸

    Gastroenterological Endoscopy　52　(Suppl.1)　793-793　2010/04

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  141. A case of gastric duplication with unique eus and endoscopic findings Peer-reviewed

    Tomohiro Masaka, Kaname Uno, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Shuichi Ohara, Tooru Shimosegawa, Iwao Sasaki, Mika Watanabe, Akio Shirane

    Gastroenterological Endoscopy　52　(1)　51-57　2010/01

    ISSN： 0387-1207

  142. Identification of the layered morphology of the esophageal wall by optical coherence tomography Peer-reviewed

    Satoshi Yokosawa, Tomoyuki Koike, Yasushi Kitagawa, Waku Hatta, Kaname Uno, Yasuhiko Abe, Katsunori Iijima, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

    WORLD JOURNAL OF GASTROENTEROLOGY　15　(35)　4402-4409　2009/09

    DOI： 10.3748/wjg.15.4402 　

    ISSN： 1007-9327

    eISSN： 2219-2840

  143. Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication Peer-reviewed

    Katsunori Iijima, Tomoyuki Koike, Yasuhiko Abe, Nobuyuki Ara, Kaname Uno, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

    JOURNAL OF GASTROENTEROLOGY　44　(8)　819-825　2009/08

    DOI： 10.1007/s00535-009-0066-2 　

    ISSN： 0944-1174

  144. Lack of Modulation of Gastric Emptying by Dietary Nitrate in Healthy Volunteers Peer-reviewed

    Shiho Terai, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Kaname Uno, Yasuhiko Abe, Tomoyuki Koike, Akira Imatani, Shuichi Ohara, Tooru Shimosegawa

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　218　(1)　73-79　2009/05

    DOI： 10.1620/tjem.218.73 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  145. H.pylori感染胃粘膜におけるNotchレセプターならびにId-1の発現

    熱海 智章, 加藤 勝章, 大楽 尚弘, 浅沼 清孝, 宇野 要, 飯島 克則, 小池 智幸, 今谷 晃, 関根 仁, 大原 秀一, 下瀬川 徹

    日本消化器病学会雑誌　101　(臨増総会)　A311-A311　2004/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

Show all ︎Show first 5

Misc. 90

  1. 予後予測のための新規基礎疾患スコア

    佐藤伊佐雄, 八田和久, 中谷久美, 中谷直樹, 尾形洋平, 齊藤真弘, 金笑奕, 宇野要, 小池智幸, 今谷晃, 中村智洋, 正宗淳, 寳澤篤

    日本消化器病学会雑誌(Web)　121　2024

    ISSN： 1349-7693

  2. PPI抵抗性GERD患者におけるexcessive supragastric belching(excessive SGB)の食道内逆流因子と有病率の検討

    首藤千博, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 谷地一真, 八田和久, 宇野要, 浅野直喜, 正宗淳

    日本消化器病学会雑誌(Web)　121　2024

    ISSN： 1349-7693

  3. Barrett食道の発癌に対する食道内逆流因子と食道運動機能の影響

    谷地一真, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 首藤千博, 八田和久, 宇野要, 浅野直喜, 正宗淳

    日本消化器病学会雑誌(Web)　121　2024

    ISSN： 1349-7693

  4. 食道胃接合部癌発育伸展におけるdysbiosis・腸管粘膜バリア傷害の役割

    須藤洸一郎, 宇野要, 玉原亨, 草野啓介, 田邊瑞樹, 菅野武, 浅野直喜, 小池智幸, 正宗淳

    日本消化器病学会雑誌(Web)　121　2024

    ISSN： 1349-7693

  5. シミュレータ学習プログラムは安全なESTの達成および自覚的習熟度の向上に寄与する 前向き教育介入研究

    畑山 裕, 菅野 武, 滝川 哲也, 松本 諒太郎, 齊藤 真弘, 金 笑奕, 三浦 晋, 八田 和久, 濱田 晋, 宇野 要, 粂 潔, 菊田 和宏, 浅野 直喜, 今谷 晃, 小池 智幸, 正宗 淳

    Gastroenterological Endoscopy　65　(Suppl.2)　2026-2026　2023/10

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  6. 【上部消化管疾患の残された課題】非Helicobacter pylori・非NSAIDs潰瘍の診療

    菅野 武, 川邉 誠, 小野 義高, 宇野 要, 小池 智幸, 正宗 淳

    Progress in Medicine　43　(9)　825-829　2023/09

    Publisher: (株)ライフ・サイエンス

    ISSN： 0287-3648

  7. 感染性大動脈-十二指腸瘻の診断にビスコクリアを用いた内視鏡観察が有用であった一例

    鈴木 直生, 齊藤 真弘, 宇野 要, 金 笑奕, 小池 智幸, 正宗 淳, 赤松 大二朗, 水間 正道, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会・日本消化器内視鏡学会東北支部例会プログラム・抄録集　215回・170回　162-162　2023/07

    Publisher: 日本消化器病学会-東北支部

  8. 胃がん2次検診で胃粘膜下腫瘍が疑われ,難治性特発性胃潰瘍であった一例

    川邉 誠, 菅野 武, 小野 義高, 宇野 要, 小池 智幸, 正宗 淳

    日本消化器がん検診学会雑誌　61　(Suppl総会)　476-476　2023/06

    Publisher: (一社)日本消化器がん検診学会

    ISSN： 1880-7666

    eISSN： 2185-1190

  9. Helicobacter pylori除菌後胃癌の抑止対策 Helicobacter pylori除菌後胃癌の抑止対策

    織内 優好, 宇野 要, 正宗 淳

    日本消化器病学会雑誌　119　(臨増大会)　A548-A548　2022/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  10. 上部消化管出血患者における,ボノプラザンのPPI内服に対する再出血・死亡リスクの検討 傾向スコアを用いたDPCデータベースの解析

    阿部 寛子, 八田 和久, たら澤 邦男, 小野 義高, 尾形 洋平, 齊藤 真弘, 菅野 武, 金 笑奕, 宇野 要, 小池 智幸, 今谷 晃, 藤森 研司, 伏見 清秀, 正宗 淳

    Gastroenterological Endoscopy　64　(Suppl.2)　2069-2069　2022/10

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  11. 出血を再現した十二指腸ESTシミュレータモデルの開発

    畑山 裕, 菅野 武, 滝川 哲也, 齊藤 真弘, 金 笑奕, 三浦 晋, 八田 和久, 濱田 晋, 宇野 要, 粂 潔, 浅野 直喜, 今谷 晃, 小池 智幸, 正宗 淳

    Gastroenterological Endoscopy　64　(Suppl.2)　2138-2138　2022/10

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  12. 上部消化管内視鏡治療におけるP-CABの後出血予防効果 propensity scoreを用いたデータベース解析

    阿部 寛子, 八田 和久, たら澤 邦男, 尾形 洋平, 齊藤 真弘, 菅野 武, 金 笑奕, 宇野 要, 小池 智幸, 今谷 晃, 藤森 研司, 伏見 清秀, 正宗 淳

    潰瘍　49　55-55　2022/10

    Publisher: (一社)日本潰瘍学会

    ISSN： 2189-7956

  13. 早期胃癌ESD後の追加胃切除術における治療成績と安全性の検討

    佐々木 啓迪, 土屋 堯裕, 山村 明寛, 田中 直樹, 井本 博文, 八田 和久, 尾形 洋平, 宇野 要, 小池 智幸, 西條 文人, 森川 孝則, 大沼 忍, 正宗 淳, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　213回　65-65　2022/07

    Publisher: 日本消化器病学会-東北支部

  14. 難治性食道狭窄を呈した微小ガストリノーマの1例

    草野啓介, 宇野要, 小池智幸, 三浦晋, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 浅野直喜, 今谷晃, 正宗淳, 益田邦洋, 大塚英郎, 海野倫明, 藤島史喜, 中堀昌人

    日本消化器病学会東北支部例会誌　212th　2022

  15. Prevention of delayed bleeding with P-CAB in upper gastrointestinal endoscopic treatment

    阿部寛子, 八田和久, たら澤邦男, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

    日本消化管学会雑誌(CD-ROM)　6　(Supplement)　2022

    ISSN： 2433-3840

  16. 内視鏡的に完全切除した胃平滑筋肉腫の一例

    谷地一真, 八田和久, 小池智幸, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 浅野直喜, 今谷晃, 渡邊裕文, 藤島史喜, 正宗淳

    日本消化器病学会東北支部例会誌　212th　2022

  17. 【消化管がん検診・スクリーニングの手引き】(第V章)上部消化管の検診で知っておくべき前癌状態と腫瘍性疾患 Barrett食道とBarrett腺癌

    小池 智幸, 齊藤 真弘, 大原 祐樹, 八田 和久, 宇野 要, 正宗 淳

    臨床消化器内科　36　(8)　982-994　2021/07

    Publisher: (株)日本メディカルセンター

    ISSN： 0911-601X

    eISSN： 2433-2488

  18. 内視鏡医学と基礎医学の融合 口腔内雑菌成分刺激による粘膜バリア傷害がピロリ菌除菌後胃発癌機序に関与する

    李 秀載, 宇野 要, 正宗 淳

    Gastroenterological Endoscopy　63　(Suppl.1)　726-726　2021/04

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  19. 歯周病菌リポ多糖類刺激によるピロリ菌除菌療法後の胃粘膜バリア傷害の検討

    織内優好, 宇野要, 李秀載, 齊藤真弘, 中川健一郎, 金笑奕, 菅野武, 八田和久, 浅野直喜, 小池智幸, 今谷晃, 正宗淳

    日本消化器病学会雑誌(Web)　118　2021

    ISSN： 1349-7693

  20. 新規内視鏡シミュレーターを用いた,消化管止血術学習プログラムによる教育介入研究

    畑山裕, 菅野武, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

    日本消化器病学会雑誌(Web)　118　2021

    ISSN： 1349-7693

  21. 40年に及ぶ疫学的評価による本邦における食道胃接合部腺癌,食道腺癌の増加

    畑山裕, 菅野武, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 金村政輝, 正宗淳

    日本消化器病学会雑誌(Web)　118　2021

    ISSN： 1349-7693

  22. Helicobacter pylori感染による分化制御遺伝子Notch1の発現抑制を介した胃粘膜萎縮機序の解明

    金笑奕, 浅野直喜, 今谷晃, 齋藤方志, 竹内章夫, 斉藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

    日本消化器病学会雑誌(Web)　118　2021

    ISSN： 1349-7693

  23. ヘリコバクターピロリ除菌後発見胃癌・未感染胃癌の病態と内視鏡診断 ピロリ菌除菌療法後発癌機序における口腔内雑菌の関与

    宇野 要, 李 秀載, 正宗 淳

    Gastroenterological Endoscopy　62　(Suppl.1)　1135-1135　2020/08

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  24. ヘリコバクターピロリ除菌後発見胃癌・未感染胃癌の病態と内視鏡診断 ピロリ菌除菌療法後発癌機序における口腔内雑菌の関与

    宇野 要, 李 秀載, 正宗 淳

    Gastroenterological Endoscopy　62　(Suppl.1)　1135-1135　2020/08

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  25. Barrett食道癌の診断

    小池 智幸, 齊藤 真弘, 大原 祐樹, 大方 智樹, 阿部 泰明, 中川 健一郎, 金 笑奕, 菅野 武, 八田 和久, 淺沼 清孝, 宇野 要, 浅野 直喜, 今谷 晃, 菊地 亮介, 猪股 芳文, 正宗 淳

    胃と腸　55　(5)　514-529　2020/05

  26. 食道扁平上皮癌における分化制御遺伝子Sox2の発現増強による発癌・血管新生機序の解明

    高橋貴一, 浅野直喜, 今谷晃, 金笑奕, 竹内章夫, 齋藤方志, 齊藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

    日本消化器病学会雑誌(Web)　117　2020

    ISSN： 1349-7693

  27. 除菌後胃癌・Hp未感染胃癌診断の現状と課題 ピロリ菌除菌後も残存する萎縮粘膜が除菌後胃癌の内視鏡診断を困難にする

    宇野 要, 李 秀載, 正宗 淳

    日本消化器病学会雑誌　116　(臨増大会)　A606-A606　2019/11

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  28. 【食道の炎症を視る】アレルギー性・自己免疫性 好酸球性食道炎の診断と治療

    浅野 直喜, 小池 智幸, 齊藤 真弘, 中川 健一郎, 金 笑奕, 八田 和久, 淺沼 清孝, 宇野 要, 今谷 晃, 正宗 淳

    消化器内視鏡　31　(8)　1179-1184　2019/08

    Publisher: (株)東京医学社

    ISSN： 0915-3217

  29. 難治性胃潰瘍を呈した好酸球性胃腸炎の一例

    大原 祐樹, 斉藤 真弘, 中川 健一郎, 金 笑奕, 八田 和久, 淺沼 清孝, 宇野 要, 浅野 直喜, 小池 智幸, 今谷 晃, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　207回　47-47　2019/07

    Publisher: 日本消化器病学会-東北支部

  30. LCIは表在型Barrett食道腺癌の視認性向上に有用である

    齊藤 真弘, 小池 智幸, 八田 和久, 阿部 泰明, 大方 智樹, 金 笑奕, 淺沼 清孝, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    Gastroenterological Endoscopy　61　(Suppl.1)　892-892　2019/05

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  31. BLI・NBI拡大内視鏡による表在型食道扁平上皮癌深達度診断の比較検討

    八田 和久, 小池 智幸, 荒 誠之, 近藤 穣, 齊藤 真弘, 金 笑奕, 淺沼 清孝, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    Gastroenterological Endoscopy　61　(Suppl.1)　893-893　2019/05

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  32. ヘリコバクター・ピロリ感染症の残された課題 除菌療法後も残存する萎縮胃粘膜の発癌ポテンシャル

    宇野 要, 李 秀載, 正宗 淳

    日本消化器病学会雑誌　116　(臨増総会)　A49-A49　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  33. 食道胃接合部から発生する高濃度一酸化窒素は食道潰瘍の創傷治癒を遅延させる

    藤谷 拓, 淺沼 清孝, 李 秀載, 八田 和久, 宇野 要, 浅野 直喜, 今谷 晃, 小池 智幸, 正宗 淳

    日本消化器病学会雑誌　116　(臨増総会)　A275-A275　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  34. 症状の季節変動を繰り返す好酸球性食道筋炎の1例

    外田 修裕, 宇野 要, 齊藤 真弘, 金 笑奕, 八田 和久, 淺沼 清孝, 浅野 直喜, 小池 智幸, 今谷 晃, 庄司 知隆, 佐藤 千晃, 亀井 尚, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　206回　85-85　2019/02

    Publisher: 日本消化器病学会-東北支部

  35. 消化管出血(静脈瘤破裂を除く)の予後不良症例の検討 高用量ステロイド投与は出血性胃十二指腸潰瘍内視鏡治療後再出血の危険因子である

    八田 和久, 小池 智幸, 齊藤 真弘, 金 笑奕, 淺沼 清孝, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    日本消化管学会雑誌　3　(Suppl.)　157-157　2019/02

    Publisher: (一社)日本消化管学会

    ISSN： 2433-3840

  36. 消化管出血(静脈瘤破裂を除く)の予後不良症例の検討 高用量ステロイド投与は出血性胃十二指腸潰瘍内視鏡治療後再出血の危険因子である

    八田 和久, 小池 智幸, 齊藤 真弘, 金 笑奕, 淺沼 清孝, 宇野 要, 浅野 直喜, 今谷 晃, 正宗 淳

    日本消化管学会雑誌　3　(Suppl.)　157-157　2019/02

    Publisher: (一社)日本消化管学会

    ISSN： 2433-3840

  37. 高用量ステロイド投与は出血性胃十二指腸潰瘍内視鏡治療後再出血の危険因子である

    八田和久, 小池智幸, 齊藤真弘, 金笑奕, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 正宗淳

    日本消化管学会雑誌　3　(Supplement)　2019

    ISSN： 2435-8967

  38. 飲酒後の食道組織中アセトアルデヒドに関する検討

    大方 英樹, 八田 和久, 飯島 克則, 淺沼 清孝, 宇野 要, 浅野 直喜, 小池 智幸, 今谷 晃, 濱田 晋, 正宗 淳, 下瀬川 徹

    日本消化器病学会雑誌　115　(臨増総会)　A266-A266　2018/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  39. 飲酒後の食道組織中アセトアルデヒドに関する検討

    大方 英樹, 八田 和久, 飯島 克則, 淺沼 清孝, 宇野 要, 浅野 直喜, 小池 智幸, 今谷 晃, 濱田 晋, 正宗 淳, 下瀬川 徹

    日本消化器病学会雑誌　115　(臨増総会)　A266-A266　2018/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  40. 【好酸球性食道炎の診断と治療】 好酸球性食道炎の画像診断-内視鏡診断

    浅野 直喜, 小池 智幸, 菅野 武, 八田 和久, 淺沼 清孝, 宇野 要, 今谷 晃, 下瀬川 徹

    胃と腸　53　(3)　291-298　2018/03

    Publisher: (株)医学書院

    ISSN： 0536-2180

  41. 【これでわかる!食道胃接合部疾患】 ここまで内視鏡でわかる食道胃接合部の構造と機能

    小池 智幸, 菊池 弘樹, 阿部 泰明, 大方 智樹, 乗田 一明, 八田 和久, 淺沼 清孝, 宇野 要, 浅野 直喜, 下瀬川 徹

    消化器内視鏡　29　(9)　1632-1642　2017/09

    Publisher: (株)東京医学社

    ISSN： 0915-3217

  42. MUCOSAL BARRIER DYSFUNCTION MAY DEVELOP GASTRIC CARCINOGENESIS AFTER SUCCESSFUL ERADICATION OF HELICOBACTER PYLORI

    Yasushi Takahashi, Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Nobuyuki Ara, Yudai Torihata, Tsugihiro Murata, Kiyotaka Asanuma, Naoki Asano, Tomoyuki Koike, Tooru Shimosegawa

    GASTROENTEROLOGY　152　(5)　S738-S738　2017/04

    ISSN： 0016-5085

    eISSN： 1528-0012

  43. Intense Gastro-Esophageal Reflux May Influence the Localization of Barrett's Adenocarcinoma: Measured by 24-h pH-Impedance Monitoring

    Masahiro Saito, Tomoyuki Koike, Hiroki Kikuchi, Kazuaki Norita, Kenichirou Nakagawa, Takeshi Kanno, Gen Kusaka, Yutaka Kondo, Waku Hatta, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Katsunori Iijima, Tooru Shimosegawa

    GASTROENTEROLOGY　150　(4)　S483-S483　2016/04

    ISSN： 0016-5085

    eISSN： 1528-0012

  44. PPI抵抗性NERD患者における24hr MLL-pHモニタリングの基線値の検討

    菊池 弘樹, 小池 智幸, 乗田 一明, 齊藤 真弘, 菅野 武, 近藤 穣, 日下 玄, 八田 和久, 荒 誠之, 淺沼 清孝, 宇野 要, 浅野 直喜, 今谷 晃, 下瀬川 徹

    日本消化器病学会雑誌　113　(臨増総会)　A229-A229　2016/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  45. GERD、Barrett食道癌の診断と治療 とくに治療法の選択について 表在型Barrett食道腺癌の内視鏡的特徴と病態および治療に関する検討

    齊藤 真弘, 小池 智幸, 中川 健一郎, 菊池 弘樹, 八田 和久, 荒 誠之, 淺沼 清孝, 宇野 要, 飯島 克則, 下瀬川 徹

    日本食道学会学術集会プログラム・抄録集　69回　21-21　2015/07

    Publisher: (NPO)日本食道学会

  46. The Risk Factors for Metastasis in Non-Ampullary Duodenal Neuroendocrine Tumors Measuring 20 mm or Less in Diameter: a Multicenter Retrospective Trial in Japan

    Waku Hatta, Tomoyuki Koike, Katsunori Iijima, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Atsuko Kasajima, Fumiyoshi Fujishima, Hironobu Sasano, Tooru Shimosegawa

    GASTROINTESTINAL ENDOSCOPY　81　(5)　AB126-AB126　2015/05

    ISSN： 0016-5107

    eISSN： 1097-6779

  47. The Usefulness of Optical Coherence Tomography in Evaluating the Extension of Barrett's Mucosa Underneath the Squamous Epithelium

    Waku Hatta, Kaname Uno, Tomoyuki Koike, Nobuyuki Ara, Naoki Asano, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa

    GASTROINTESTINAL ENDOSCOPY　81　(5)　AB392-AB392　2015/05

    ISSN： 0016-5107

    eISSN： 1097-6779

  48. Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression

    Junya Honda, Katsunori Iijima, Gen Kusaka, Yutaka Kondo, Waku Hatta, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

    GASTROENTEROLOGY　148　(4)　S740-S741　2015/04

    ISSN： 0016-5085

    eISSN： 1528-0012

  49. Effects of Inflammation on Senescence in Epithelial Cells Is Mediated by Fibroblasts in Barrett's Esophagus

    Kaname Uno, Marlys Anderson, Lori S. Lutzke, Cadman L. Leggett, Kenneth K. Wang

    GASTROENTEROLOGY　146　(5)　S148-S148　2014/05

    ISSN： 0016-5085

    eISSN： 1528-0012

  50. 当院における頭頸部癌治療後消化管狭窄への内視鏡的バルーン拡張術の検討

    前嶋 隆平, 飯島 克則, 本田 純也, 白木 健悠, 中川 健一郎, 金 笑奕, 菅野 武, 新海 洋彦, 伏谷 淳, 近藤 穣, 八田 和久, 遠藤 博之, 荒 誠之, 宇野 要, 浅野 直喜, 小池 智幸, 今谷 晃, 下瀬川 徹

    Gastroenterological Endoscopy　56　(Suppl.1)　1070-1070　2014/04

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  51. Identification of a high-risk group for low-dose aspirin-induced gastropathy by measuring serum pepsinogen in H. pylori-infected subjects.

    Iijima, K, Koike, T, Ara, N, Nakagawa, K, Kondo, Y, Uno, K, Hatta, W, Asano, N, Imatani, A, Shimosegawa, T

    J Gastroenterol　2014

    DOI： 10.1007/s00535-014-0976-5 　

  52. Diagnosing Dysplasia in Barrett's Esophagus Using Volumetric Laser Endomicroscopy: Submucosal Gland Characteristics

    Cadman Leggett, Emmanuel Gorospe, Kaname Uno, Subhash Chandra, Daniel Chan, Marlys Anderson, Lori Lutzke, Kenneth Wang

    AMERICAN JOURNAL OF GASTROENTEROLOGY　108　S32-S32　2013/10

    ISSN： 0002-9270

    eISSN： 1572-0241

  53. 消化管の新たな映像(第10回) Optical coherence tomography(OCT)

    八田 和久, 飯島 克則, 宇野 要, 荒 誠之, 小池 智幸, 下瀬川 徹

    Frontiers in Gastroenterology　18　(3)　238-243　2013/07

    Publisher: (株)メディカルレビュー社

    ISSN： 1342-1484

  54. 胃集団検診にて発見された胃腺腫様病変のサーベイランス中にリンパ節転移も伴う粘膜下層浸潤胃型腺癌を認めた一例

    荒 誠之, 宇野 要, 小池 智幸, 浅野 直喜, 飯島 克則, 今谷 晃, 下瀬川 徹, 菊地 亮介, 加藤 勝章, 渋谷 大助

    日本消化器がん検診学会雑誌　51　(1)　131-132　2013/01

    Publisher: (一社)日本消化器がん検診学会

    ISSN： 1880-7666

  55. Association of gastric atrophy with superficial esophageal squamous cell carcinoma

    飯島 克則, 宇野 要, 小池 智幸

    消化器内科　55　(4)　413-415　2012/10

    Publisher: 科学評論社

    ISSN： 1884-2895

  56. 食道表在癌(扁平上皮癌・腺癌)に対する内視鏡治療後の予後に関する検討

    中川 健一郎, 小池 智幸, 宇野 要, 白木 健悠, 金 笑奕, 菅野 武, 荒 誠之, 浅野 直喜, 阿部 靖彦, 飯島 克則, 今谷 晃, 下瀬川 徹

    Gastroenterological Endoscopy　54　(Suppl.2)　2840-2840　2012/09

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  57. 食道胃接合部腺癌・噴門部癌に対する内視鏡治療後の予後に関する検討

    中川 健一郎, 小池 智幸, 宇野 要, 白木 健悠, 金 笑奕, 菅野 武, 荒 誠之, 浅野 直喜, 阿部 靖彦, 飯島 克則, 今谷 晃, 下瀬川 徹

    Gastroenterological Endoscopy　54　(Suppl.2)　2882-2882　2012/09

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  58. Influence of Meals on the Pharmacokinetics of Proton Pump Inhibitors in Healthy Japanese Subjects

    Hirohiko Shinkai, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Naoki Asano, Yasuhiko Abe, Katsunori Iijima, Akira Imatani, Masamitsu Maekawa, Yotaro Matsumoto, Miki Shimada, Nariyasu Mano, Tooru Shimosegawa

    GASTROENTEROLOGY　142　(5)　S215-S215　2012/05

    ISSN： 0016-5085

  59. Gastric Hypochlorhydria is Associated With an Exacerbation of Dyspeptic Symptoms in Female Patients

    Wataru Iwai, Yasuhiko Abe, Katsunori Iijima, Tomoyuki Koike, Kaname Uno, Naoki Asano, Akira Imatani, Tooru Shimosegawa

    GASTROENTEROLOGY　142　(5)　S468-S468　2012/05

    ISSN： 0016-5085

  60. Paradoxical Effects of H-pylori Infection on Low-Dose Aspirin Induced Gastropathy Depending on the Gastric Acid Secretion Level

    Katsunori Iijima, Nobuyuki Ara, Yasuhiko Abe, Tomoyuki Koike, Toshimitsu Iwabuchi, Kaname Uno, Hiroyuki Endo, Naoki Asano, Akira Imatani, Tooru Shimosegawa

    GASTROENTEROLOGY　142　(5)　S103-S103　2012/05

    ISSN： 0016-5085

  61. A Prospective Study About the Accuracy of the Preoperative Diagnosis of Invasion Depth of Superficial Esophageal Squamous Cell Carcinoma by Optical Coherence Tomography Compared With That by High-Frequency Endoscopic Ultrasonography

    Waku Hatta, Kaname Uno, Tomoyuki Koike, Naoki Asano, Yasuhiko Abe, Katsunori Iijima, Tooru Shimosegawa

    GASTROINTESTINAL ENDOSCOPY　75　(4)　127-127　2012/04

    ISSN： 0016-5107

  62. 食道表在癌(扁平上皮癌・腺癌)に対する内視鏡治療後の長期経過に関する検討

    中川 健一郎, 小池 智幸, 宇野 要, 白木 健悠, 金 笑奕, 管野 武, 荒 誠之, 浅野 直善, 阿部 靖彦, 飯島 克則, 今谷 晃, 下瀬川 徹

    Gastroenterological Endoscopy　54　(Suppl.1)　1063-1063　2012/04

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  63. 【Helicobacter pylori除菌後の胃癌】 Helicobacter pylori除菌によって何が変わるのか? 胃酸分泌の変化

    飯島克則, 小池智幸, 荒誠之, 宇野要, 浅野直喜, 下瀬川徹, 阿部靖彦, 関根仁, 大原秀一

    胃と腸　47　(11)　1663-1670　2012

    DOI： 10.11477/mf.1403113622 　

  64. 【食道・中下咽頭表在癌の診断と治療】 食道表在癌深達度診断におけるOCT(optical coherence tomography)の有効性

    宇野 要, 八田 和久, 横沢 聡, 小池 智幸, 荒 誠之, 浅野 直喜, 飯島 克則, 今谷 晃, 下瀬川 徹

    消化器内科　55　(4)　424-430　2012

  65. 【Barrett食道癌の診断】主題 Barrett食道癌の内視鏡診断 通常観察での拾い上げ診断のポイント

    小池 智幸, 阿部 靖彦, 飯島 克則, 中川 健一郎, 新海 洋彦, 遠藤 博之, 荒 誠之, 宇野 要, 浅野 直喜, 今谷 晃, 下瀬川 徹, 大原 秀一

    胃と腸　46　(12)　1800-1814　2011/11

    Publisher: (株)医学書院

    ISSN： 0536-2180

  66. 【変わったぞ「消化管出血のマネジメント」】上部消化管 出血性消化性潰瘍に対する止血法 純エタノール局注法を中心に

    小池 智幸, 阿部 靖彦, 宇野 要, 中川 健一郎, 新海 洋彦, 千葉 隆士, 岩渕 利光, 岩井 渉, 荒 誠之, 浅野 直喜, 飯島 克則, 今谷 晃, 下瀬川 徹

    消化器内視鏡　23　(11)　1857-1864　2011/11

    Publisher: (株)東京医学社

    ISSN： 0915-3217

  67. 【Barrett食道腺癌の診断と治療-その問題点と対策-】Barrett食道腺癌のサーベイランスをどう行うか 問題点と対策

    小池 智幸, 阿部 靖彦, 飯島 克則, 中川 健一郎, 新海 洋彦, 荒 誠之, 宇野 要, 今谷 晃, 下瀬川 徹

    消化器の臨床　14　(5)　505-509　2011/10

    Publisher: (株)ヴァンメディカル

    ISSN： 1344-3070

  68. Gastric Cancers Emerging After H. pylori Eradication Arise Exclusively From Functionally Irreversible Non-Acid Secreting Areas

    Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Hiroyuki Endo, Naoki Asano, Kiyotaka Asanuma, Kaname Uno, Akira Imatani, Tooru Shimosegawa

    GASTROENTEROLOGY　140　(5)　S186-S186　2011/05

    ISSN： 0016-5085

  69. Gender Differences in Esophageal Mucosal Injury in a Reflux Esophagitis Model of Rats

    Tomohiro Masaka, Katsunori Iijima, Tooru Shimosegawa, Akira Imatani, Tomoyuki Koike, Yasuhiko Abe, Naoki Asano, Kiyotaka Asanuma, Kaname Uno

    GASTROENTEROLOGY　140　(5)　S627-S627　2011/05

    ISSN： 0016-5085

  70. The Direct Measurement of Non-Acid Reflux Episodes in Patients With or Without Squamous Cell Carcinoma by 24 Hours pH-Impedance Monitoring

    Kaname Uno, Katsunori Iijima, Tomoyuki Koike, Nobuyuki Ara, Waku Hatta, Gen Kusaka, Tooru Shimosegawa

    GASTROENTEROLOGY　140　(5)　S669-S669　2011/05

    ISSN： 0016-5085

  71. 【Helicobacter pylori除菌後GERDの実態】 Helicobacter pylori除菌後のGERD 発生メカニズムは? (Helicobacter Research)

    小池智幸, 飯島克則, 阿部靖彦, 遠藤博之, 浅沼清孝, 宇野要, 浅野直喜, 今谷晃, 下瀬川徹, 大原秀一

    Helicobacter Research　15　(1)　32-41　2011

  72. 上腹部症状と胃酸分泌能に関する検討

    岩井 渉, 阿部 靖彦, 小池 智幸, 飯島 克則, 浅野 直喜, 宇野 要, 荒 誠之, 今谷 晃, 下瀬川 徹

    日本消化器病学会雑誌　107　(臨増大会)　A776-A776　2010/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  73. The Use of Optical Coherence Tomography in Staging Tumor Invasion of Superficial Esophageal Squamous Cell Carcinoma

    Waku Hatta, Kaname Uno, Tomoyuki Koike, Nobuyuki Ara, Yasuhiko Abe, Katsunori Iijima, Tooru Shimosegawa

    GASTROINTESTINAL ENDOSCOPY　71　(5)　AB198-AB199　2010/04

    ISSN： 0016-5107

  74. 外因性一酸化窒素(NO)によるバレット食道発生に対する影響について (Therapeutic Research)

    遠藤博之, 浅沼清孝, 飯島克則, 荒誠之, 宇野要, 浅野直喜, 阿部靖彦, 小池智幸, 今谷晃, 大原秀一, 下瀬川徹

    Therapeutic Research　31　(4)　491-496　2010/04

  75. 【やっぱり大切、基本手技】 上部消化管[治療] 局注止血術の基本手技 出血性潰瘍に対する純エタノール局注法を中心に (消化器内視鏡)

    小池智幸, 阿部靖彦, 宇野要, 飯島克則, 下瀬川徹

    消化器内視鏡　22　(4)　501-504　2010/04

  76. 当科に於けるPEGの現状

    岩井 渉, 荒 誠之, 小池 智幸, 日下 玄, 近藤 穣, 真坂 智寛, 海上 寛之, 八田 和久, 伊藤 博敬, 遠藤 博之, 菊地 亮介, 小西 秀知, 堀井 享, 石山 文威, 及川 智之, 小林 茂之, 寺井 志保, 浅沼 清孝, 宇野 要, 阿部 靖彦, 飯島 克則, 今谷 晃, 朝倉 徹, 大原 秀一, 下瀬川 徹

    静脈経腸栄養　25　(2)　627-627　2010/03

    Publisher: (株)ジェフコーポレーション

    ISSN： 1344-4980

  77. 大学病院に於けるPEG造設の現状

    荒 誠之, 小池 智幸, 岩渕 利光, 千葉 隆士, 日下 玄, 近藤 穣, 真坂 智寛, 海上 寛之, 八田 和久, 伊藤 博敬, 遠藤 博之, 菊地 亮介, 小西 秀知, 堀井 享, 宇野 要, 浅野 直喜, 阿部 靖彦, 飯島 克則, 今谷 晃, 朝倉 徹, 下瀬川 徹

    静脈経腸栄養　25　(2)　631-631　2010/03

    Publisher: (株)ジェフコーポレーション

    ISSN： 1344-4980

  78. 【Barrett食道の最前線 腺癌発生のメカニズム】 食道胃接合部癌の臨床病理学的特徴と病態 とくにHelicobacter pylori感染と胃酸分泌の面からみた病態について

    阿部 靖彦, 大原 秀一, 小池 智幸, 堀井 享, 飯島 克則, 浅野 直喜, 宇野 要, 荒 誠之, 今谷 晃, 下瀬川 徹

    G.I.Research　18　(1)　24-30　2010/02

    Publisher: (株)先端医学社

    ISSN： 0918-9408

  79. 著明な形態変化と非典型的なEUS像を呈した成人胃重複症の1例

    眞坂智寛, 宇野要, 阿部靖彦, 飯島克則, 小池智幸, 大原秀一, 下瀬川徹, 佐々木巌, 渡辺みか, 白根昭男

    Gastroenterological Endoscopy　52　(1)　51-57　2010

    DOI： 10.11280/gee.52.51 　

  80. 【Barrett食道の最前線 腺癌発生のメカニズム】 食道胃接合部癌の臨床病理学的特徴と病態 とくにHelicobacter pylori感染と胃酸分泌の面からみた病態について (G.I.Research)

    阿部靖彦, 大原秀一, 小池智幸, 堀井享, 飯島克則, 浅野直喜, 宇野要, 荒誠之, 今谷晃, 下瀬川徹

    G.I.Research　18　(1)　24-30　2010

  81. 噴門部小彎からの出血を繰り返し治療に難渋した胃食道静脈瘤の1例

    荒 誠之, 小池 智幸, 宇野 要, 浅野 直喜, 阿部 靖彦, 飯島 克則, 今谷 晃, 下瀬川 徹, 及川 圭介, 杉山 幸一

    日本門脈圧亢進症学会雑誌　15　(1)　95-95　2009/08

    Publisher: (一社)日本門脈圧亢進症学会

    ISSN： 1344-8447

  82. 食道静脈瘤を伴う食道表在癌に対する内視鏡治療

    宇野 要, 小池 智幸, 飯島 克則, 阿部 靖彦, 浅野 直喜, 荒 誠之, 今谷 晃, 下瀬川 徹, 萱場 尚一

    日本門脈圧亢進症学会雑誌　15　(1)　108-108　2009/08

    Publisher: (一社)日本門脈圧亢進症学会

    ISSN： 1344-8447

  83. 【消化管症候群(第2版) その他の消化管疾患を含めて】 胃 胃粘膜下腫瘍 (日本臨床)

    大原秀一, 小池智幸, 阿部靖彦, 宇野要

    日本臨床　別冊　(消化管症候群(上))　403-406　2009/07

  84. 【バレット食道の取扱い】 Barrett食道癌を含む食道胃接合部癌の病態 (消化器科)

    小池智幸, 堀井享, 阿部靖彦, 荒誠之, 宇野要, 浅野直喜, 飯島克則, 今谷晃, 下瀬川徹

    消化器科　49　(1)　62-68　2009/07

  85. The Aggravative Effect of Gastric Acid On Low Dose Aspirin Induced Gastric Mucosal Injury: Examination By Endoscopic Gastrin Test

    Nobuyuki Ara, Katsunori Iijima, Akira Imatani, Tomoyuki Koike, Yasuhiko Abe, Naoki Asano, Kaname Uno, Kiyotaka Asanuma, Shuichi Ohara, Tooru Shimosegawa

    GASTROENTEROLOGY　136　(5)　A185-A185　2009/05

    ISSN： 0016-5085

  86. 【内視鏡イメージングの進化】 Confocal Endomicroscopy OCTによる食道表在癌深達度診断 (消化器内視鏡)

    八田和久, 宇野要, 横沢聡, 阿部靖彦, 飯島克則, 小池智幸, 大原秀一, 下瀬川徹

    消化器内視鏡　21　(2)　288-295　2009

  87. Helicobacter pylori lipopolysaccharide enhances the production of iNOS-derived NO in cooperation with the induction of toll-like receptor (TLR) 2 through TLR4 in gastric epithelial cells

    Uno Kaname, Kato Katsuaki, Ohara Shuichi, Shimosegawa Tooru

    GASTROENTEROLOGY　130　(4)　A528-A528　2006/04

    ISSN： 0016-5085

  88. Effect of cyclooxygenase activity on nitric oxide from inducible nitric oxide synthase in the gastric mucosa in vivo rat endotoxemia model

    K Uno, Y Iuchi, J Fujii, H Sugata, K Iijima, K Kato, T Simosegawa, T Yoshimura

    NITRIC OXIDE-BIOLOGY AND CHEMISTRY　11　(1)　102-103　2004/08

    ISSN： 1089-8603

  89. Expression of Notch receptors and Id proteins in human gastric mucosa with H.pylori infection

    T Atsumi, K Kato, N Dairaku, K Uno, S Ohara, T Shimosegawa

    GASTROENTEROLOGY　126　(4)　A534-A534　2004/04

    ISSN： 0016-5085

  90. Cross-talk between inducible nitric oxide synthase and cyclooxygenase-2 in the gastric mucosa of in vivo rat endotoxemia model

    K Uno, K Kato, N Dairaku, S Ohara, Y Iuchi, J Fujii, T Shimosegawa, T Yoshimura

    GASTROENTEROLOGY　126　(4)　A614-A614　2004/04

    ISSN： 0016-5085

Show all ︎Show first 5

Research Projects 6

  1. Periodontal disease bacteria may promote carcinogenesis at esophagogastric junction through intestinal mucosal barrier dysfuntion

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04 - 2026/03

  2. A role of oral microbiome in gastric mucosal damage during gastric carcinogenesis after Helicobacter pylori eradication treatment

    UNO KANAME

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/04 - 2022/03

    More details Close

    Numbers of gastric cancer (GC) after Helicobacter pylori eradication increased. As suggested that oncogenic mutants might expand through replacing apoptotic cells of the surrounding mucosa, we aimed to clarify whether the components of oral microbes might promote gastric carcinogenesis. Biopsies from corpus mucosa of 37 GC patients after the eradication were histologically metaplastic and inflamed mucosa with high expressions of TLR2. In a mini-Ussing chamber system, the stimulation with PG+ALD significantly reduced mucosal impedance with increase in the Bax/Bcl2 ratio. In MKN7, the TLR2-apoptosis axis were induced by the stimulations, and they were suppressed by an antibody and shRNA for human-TLR2. Using K19-Wnt1/C2mE (Gan) mice, the TLR2-apoptosis axis in background mucosa and the GC growth were observed by the 15-week stimulation. We demonstrated that the PG+ALD stimulation might develop gastric carcinogenesis through barrier dysfunction via the TLR2-apoptosis cascade.

  3. Novel role of cellular senescence in gastric carcinogenesis after Helicobacter pylori eradication

    Uno Kaname

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04 - 2018/03

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    Gastric cancer (GC) after eradication for Helicobacter pylori (H.pylori) increases, but its carcinogenesis is not elucidated. It is mainly found in acid non-secretion areas (ANA), as mucosal regeneration in acid secretory areas (AA) after eradication changes the acidity and bile toxicity of gastric juice. We aimed to clarify the role of barrier dysfunction of ANA by the stimulation of pH3 bile acid cocktail (ABC) during carcinogenesis (UMIN00018967). Using a mini-Ussing chamber system for human biopsy specimens followed by an in vitro study, we demonstrated for the first time that the exposure of acidic bile salts to ANA might cause serious barrier dysfunction through production of reactive oxygen species followed by let-7a reduction, which may promote epithelial-mesenchymal transition as well as inhibit cellular senescence process, during inflammation-associated carcinogenesis even after eradication.

  4. Helicobacter pylori 除菌後胃癌発癌機序におけるマイクロRNAによる細胞老化制御機構の解明 Competitive

    宇野 要

    Offer Organization: 宮城県対がん協会

    System: 黒川利雄癌研究基金

    2015/04 - 2016/03

  5. Role of 4-hydroxynonenal in gastric-type carcinogenesis after eradication of Helicobacter pylori

    UNO Kaname

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2012/04 - 2015/03

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    After the indication of Helicobacter pylori (H.pylori) eradication has been widespread, the number of gastric cancer occured in post-eradicated patients has increased. Therefore, to elucidate post-eradication gastric carcinogenesis is an urgent task. We aimed to clarify a role of 4-hydroxynonenal in the carcinogenesis development of post-eradicated patients, compared with H.pylori-associated gastric cancer. Using human biopsy specimens, we demonstrated sequencial increase of protein expression of HNE and p16/p14 during the carcinogenesis, nonetheless of the decrease of p14/p16 methylation only in gastric area with recovering acid secretion after eradication. Therefore, another epigenetic abnormality may play an important role in the carcinogenesis.

  6. The role of HNE in the phosphorylation of EGFR for the development of esophageal squamous cell carcinoma. Competitive

    UNO Kaname

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2010/04 - 2012/03

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    Oxidative stress might participate in the carcinogenesis of human esophageal squamous cell carcinoma (hESCC). 4-hydroxynonenal (HNE)is a major product of membrane lipid peroxidation trapped with glutathione (GSH)and catalyzed by glutathione S-transferases (GSTs). HNE is known to activate epidermal growth factor receptor (EGFR)signaling. This study aimed to elucidate the possible participation of HNE, the GSH/GST system and EGFR signaling in hESCC development. We first demonstrated that the ligand-independent activation of EGFR by the balance between HNE and the intrinsic GSH/GST system might participate in the development of hESCC. These would provide useful clues for cancer prevention and treatment of hESCC.

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Media Coverage 1

  1. メタボリック症候群が胃噴門部腺癌を進展させる機序を解明 Myself

    東北大学、東北大学東北メガバンク機構　プレスリリース

    2025/09

    Type: Other