東北大学研究者紹介

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タカセ　ケイ

高瀬　圭

Kei Takase

所属

大学院医学系研究科　医科学専攻　内科病態学講座（放射線診断学分野）

職名

教授

学位

博士（医学）（東北大学）

researchmap

https://researchmap.jp/rad-kei

J-GLOBAL ID

201801002721607420

e-Rad 研究者番号

60361094

経歴 12

2023年4月～継続中

東北大学　医学部　医学科長
2015年～継続中

東北大学病院　放射線診断科　科長
2015年～継続中

東北大学大学院医学系研究科　放射線診断学分野　教授
2010年～ 2015年

東北大学医学部　放射線診断科　准教授
2007年～ 2010年

東北大学医学部　放射線診断科　助教
2003年～ 2007年

東北大学医学部　放射線診断科　助手
2005年～ 2006年

フンボルト大学シャリテ病院　放射線科
1997年～ 2003年

石巻赤十字病院放射線科　部長
1994年～ 1997年

国立循環器病センター　放射線診療部
1993年～ 1994年

公立佐沼総合病院　放射線科
1992年～ 1993年

仙台社会保険病院　放射線科
1989年～ 1991年

東北大学医学部付属病院　放射線科　研修医

︎全件表示 ︎最初の5件までを表示

学歴 2

東北大学　医学部　医学科

1983年～ 1989年
栃木県立佐野高校

～ 1983年

研究キーワード 2

インターベンショナルラジオロジー
放射線診断学

研究分野 2

ライフサイエンス / 代謝、内分泌学 /
ライフサイエンス / 放射線科学 / 放射線診断学

受賞 4

Certificate of Merit

2012年11月　北米放射線学会　What Radiologists Should know and Do for Adrenal Hypertension -Disease Concept, Diagnostic Imaging, Venous Sampling and Interventional Radiological Treatment-
Magna Cum Laude

2012年3月　欧州放射線学会　Adrenal venous sampling revisited - Crucial role in the management of primary aldosteronism patients
Certificate of Merit

2005年　北米放射線学会　Non-thrombotic occlusion of hemodialysis access: Disease concept, Diagnosis, and Intervention.
Certificate of Merit

2003年　北米放射線学会　How to utilize Color Doppler Ultrasound in IVR of Brescia-Cimino shunt

論文 315

Identification of Adamkiewicz artery by 4D flow MRI and intra-arterial ultra-high-resolution CT angiography in preoperative assessment of patients with chronic aortic dissection: A case report

Satoshi Higuchi, Yuta Sato, Hideki Ota, Ryuichi Mori, Yuki Ichinoseki, Hitoshi Nemoto, Shingo Kayano, Kiichiro Kumagai, Yoshikatsu Saiki, Kei Takase

Radiology Case Reports　20　(3)　1581-1585　2025年3月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.radcr.2024.12.001 　

ISSN：1930-0433
Reduced 18F-FDG uptake in the basal interventricular septum as a predictor of fatal ventricular arrhythmic events in patients with cardiac sarcoidosis. 国際誌

Kouki Takeuchi, Hideaki Suzuki, Kentaro Takanami, Hideki Ota, Yoshitaka Tanaka, Fumiyoshi Fujishima, Hirofumi Watanabe, Kai Susukita, Takumi Inoue, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Takashi Suzuki, Kei Takase, Satoshi Yasuda

International journal of cardiology　419　132686-132686　2025年1月15日

DOI： 10.1016/j.ijcard.2024.132686 　

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BACKGROUND: Patients with cardiac sarcoidosis (CS) are at an increased risk of fatal ventricular arrhythmic events (FVAE). However, the predictive value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in assessing the risk of FVAE in patients with CS remains uncertain. METHODS: We included data from 121 patients with CS (39 men and 82 women; mean age: 59.5 years) who underwent FDG-PET imaging between March 2008 and November 2020, with follow-ups completed in July 2023. Of these, 82 patients had available cardiac magnetic resonance imaging data, including late gadolinium enhancement (LGE). FDG-PET images were analysed using a polar-map model to determine the regional mean percentage uptake relative to the maximal cardiac 18F-FDG uptake in each of the 17 segments defined by the American Heart Association. RESULTS: Patients experiencing FVAE after FDG-PET (n = 43) showed lower percent uptake in the basal inferoseptal segment compared to those who did not (n = 78) (41.8 ± 15.2 % vs. 54.4 ± 13.8 %, P < 0.001). Patients with a basal inferoseptal percent uptake below the median had a lower FVAE-free survival rate than those with a higher percent uptake (58.1 % vs. 78 % at 5 years, P = 0.007), which was consistent in patients with LGE in the same regions with reduced 18F-FDG uptake. A Cox hazard model indicated that the FVAE risk decreased with a hazard ratio of 0.862 (95 % CI 0.770-0.964) for every 5 % increase in basal inferoseptal percent uptake (P = 0.009). CONCLUSION: Reduced 18F-FDG uptake in the basal interventricular septum, including the inferoseptal segment, may be a valuable predictor of future FVAE in patients with CS.
Magnetic Resonance Imaging Texture Analysis Based on Intraosseous and Extraosseous Lesions to Predict Prognosis in Patients with Osteosarcoma

Yu Mori, Hainan Ren, Naoko Mori, Munenori Watanuki, Shin Hitachi, Mika Watanabe, Shunji Mugikura, Kei Takase

Diagnostics　2024年11月15日

DOI： 10.3390/diagnostics14222562 　
Role of radiologists in the diagnosis and management of adrenal disorders.

Sota Oguro, Hiromitsu Tannai, Hideki Ota, Kazumasa Seiji, Hiroki Kamada, Yoshitaka Toyama, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh, Sadayoshi Ito, Tetsuhiro Tanaka, Hideki Katagiri, Kei Takase

Endocrine journal　2024年10月10日

DOI： 10.1507/endocrj.EJ24-0156 　

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This study aimed to focus on the role of radiologists in the diagnosis and management of adrenal lesions, particularly primary aldosteronism (PA) and secondary hypertension. As hypertension affects more than one-third of the population in Japan, identifying secondary causes such as PA and adrenal lesions is crucial. Establishing a radiological differential diagnosis of adrenal lesions using advanced imaging techniques, such as computed tomography and magnetic resonance imaging, is crucial. Knowledge of the imaging findings of various benign and malignant adrenal lesions, such as adrenocortical adenomas, cortisol-producing lesions, pheochromocytomas, adrenocortical carcinoma, malignant lymphoma, and metastatic tumors, is necessary. Adrenal venous sampling (AVS) plays a crucial role in accurately localizing aldosterone hypersecretion in PA, especially when imaging fails to provide a clear diagnosis. This paper details the technical aspects of AVS, emphasizing catheterization techniques, anatomical considerations, and the importance of preprocedural imaging for successful sampling. Furthermore, we explore segmental adrenal venous sampling (SAVS), a more refined technique that samples specific adrenal tributary veins, offering enhanced diagnostic accuracy, particularly for microadenomas or challenging cases that may be missed with conventional AVS. The methodology for performing SAVS, along with the interpretation criteria for successful sampling and lateralization, is also outlined. Furthermore, radiologists have initiated treatments for unilateral PA, such as radiofrequency ablation, and play an integral role in the management of adrenal lesions. Collaborative approaches across clinical departments are required to enhance patient management in medical care involving the adrenal gland.
Introduction and evaluation of size-specific DLP for radiation dose estimation in CT examinations. 国際誌

Yutaka Dendo, Keisuke Abe, Shu Onodera, Shingo Kayano, Hideki Ota, Kei Takase

Journal of radiological protection : official journal of the Society for Radiological Protection　2024年10月9日

DOI： 10.1088/1361-6498/ad8500 　

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The increased utilization of computed tomography (CT) has raised concerns about patient radiation exposure. Effective dose (ED), which requires precise estimation, is crucial for assessing and managing these risks. Traditional ED estimation methods, which are based on the dose-length product (DLP), often lack accuracy due to variations in patient size and anatomy. This study aims to evaluate the efficacy of size-specific DLP (SS-DLP), a novel metric that combines the size-specific dose estimate (SSDE) with scan length, to provide a more accurate estimation of radiation exposure from CT examinations. Focusing on adult chest-abdomen-pelvis (CAP) scans, we calculated SSDE and SS-DLP and utilized two simulation tools, Radimetrics and WAZA-ARI, for a detailed analysis. Our findings indicate that SS-DLP is highly correlated with EDs from Monte Carlo simulations, suggesting its reliability. Additionally, SS-DLP showed a moderate reduction in errors based on patient sex and body mass index compared to traditional DLP-based methods. Thus, SS-DLP offers a more accurate and personalized radiation exposure estimate, potentially enhancing patient safety.
Improving Balloon Pulmonary Angioplasty Through Target Endpoint Optimization With Pressure Catheter and Angiographic Lung Perfusion

Taijyu Satoh, Nobuhiro Yaoita, Satoshi Higuchi, Kotaro Nochioka, Saori Yamamoto, Haruka Sato, Kaito Yamada, Yusuke Yamada, Kohei Komaru, Naoki Chiba, Mitsuru Nakada, Satoshi Miyata, Hideki Ota, Kei Takase, Satoshi Yasuda

JACC: Cardiovascular Interventions　17　(20)　2394-2407　2024年10月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.jcin.2024.08.045 　

ISSN：1936-8798
Cost-effectiveness analysis of segmental adrenal venous sampling with radiofrequency ablation for primary aldosteronism in Japan

Satoru Yanagaki, Kei Omata, Sota Oguro, Hideki Ota, Tomomi Sato, Hiroki Kamada, Hiromitsu Tannai, Yuta Tezuka, Yoshikiyo Ono, Miho Sato, Hiroyuki Ohbe, Kei Takase

Japanese Journal of Radiology　2024年9月25日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s11604-024-01665-6 　

ISSN：1867-1071

eISSN：1867-108X

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Abstract Purpose The purpose of this study was to evaluate the cost-effectiveness of comprehensive treatment strategy, including segmental adrenal venous sampling (sAVS) and radiofrequency ablation (RFA), versus medication-only strategy for primary aldosteronism. Materials and methods A Markov decision model was developed to compare the cost-effectiveness of a comprehensive treatment strategy and a medication-only strategy for 50-year-old men and women with stage I–III hypertension. The comprehensive treatment strategy included aldosterone/renin ratio measurement, two loading tests, computed tomography, sAVS, drugs, surgery, and RFA. We built a model with a yearly cycle over 32- and 38-year time horizons for men and women, respectively, and four health states: hypertension, heart failure, stroke, and death. The incremental cost-effectiveness ratio (ICER), expressed as Japanese yen per quality-adjusted life-years (QALYs), was estimated, and strategy preference was determined on the basis of 5 million Japanese yen per QALY societal willingness-to-pay threshold. Results The ICERs of the comprehensive treatment strategy over the medication-only strategy were 201,482 and 3,399 JPY per QALY for men and women, respectively. The resultant ICER was less than the 5 million JPY societal willingness-to-pay threshold. Deterministic sensitivity analysis and probabilistic sensitivity analysis revealed that the results varied with the input values, but the comprehensive strategy was likely to be more cost-effective than the medication-only strategy. Conclusion This cost-effectiveness study revealed that a comprehensive treatment strategy including sAVS and RFA was favorable compared with the medication-only strategy for managing stage I–III hypertension in 50-year-old men and women, with acceptable willingness-to-pay thresholds. Secondary abstract This cost-effectiveness study revealed that a comprehensive treatment strategy for primary aldosteronism that included segmental adrenal sampling and radiofrequency ablation was favorable compared with the medication-only strategy for managing stage I–III hypertension in 50-year-old men and women, with acceptable willingness-to-pay thresholds.
Prophylactic splenic artery embolization using n-butyl-2-cyanoacrylate and coils prior to endoscopic necrosectomy in a patient with necrotizing pancreatitis: A case report. 国際誌

Hiroki Kamada, Sota Oguro, Tatsuro Fukushi, Hiromitsu Tannai, Hideki Ota, Kei Takase

Radiology case reports　19　(8)　3483-3487　2024年8月

DOI： 10.1016/j.radcr.2024.05.027 　

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We present a case of prophylactic endovascular embolization in a 51-year-old man with necrotizing pancreatitis (NP) before undergoing endoscopic necrosectomy (EN). Contrast-enhanced CT imaging revealed the presence of a walled-off necrosis (WON) surrounding the pancreas, with the splenic artery coursing through the cavity. The splenic artery was embolized using n-butyl-2-cyanoacrylate (NBCA) and coils to mitigate the risk of massive bleeding in EN. A newly developed polytetrafluoroethylene (PTFE)-coated microcatheter was used to inject NBCA, enabling embolization of a long segment of the splenic artery without adhering to the vessel wall. Coils were placed distal and proximal to the embolized segment to optimize control. Over 5 sessions of EN, no massive bleeding was encountered. This report demonstrates the benefits of utilizing PTFE-coated microcatheters for enhanced safety and maneuverability during embolization with NBCA. Furthermore, it highlights the importance of prophylactic embolization during EN for managing NP.
Two-session embolization of portosystemic shunt presenting with hepatic encephalopathy via transvenous and trans-paraumbilical approaches: A case report. 国際誌

Hiroki Kamada, Tomomi Sato, Sota Oguro, Hideki Ota, Kei Takase

Radiology case reports　19　(6)　2112-2116　2024年6月

DOI： 10.1016/j.radcr.2024.02.057 　

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We describe the endovascular embolization of a 65-year-old man with chronic hepatic encephalopathy. A contrast-enhanced computed tomography demonstrated a splenorenal shunt and a recanalized paraumbilical vein as a continuous portal shunt connecting the left branch of the portal vein and the right common femoral vein. A 2-session embolization was performed for the splenorenal shunt. First, the transvenous approach was used for coil embolization of the splenorenal shunt. It was difficult to advance the catheter system to the embolization site, and it was unstable during coil placement. Second, the paraumbilical venous approach was used to place additional coils. The catheter system had good maneuverability and easily reached the embolization site. Additionally, the stable system allowed for densely packed additional coil implantations. This report demonstrated the paraumbilical venous approach's effectiveness in catheter maneuverability and system stability during coil embolization.
Predicting isocitrate dehydrogenase status among adult patients with diffuse glioma using patient characteristics, radiomic features, and magnetic resonance imaging: Multi-modal analysis by variable vision transformer. 国際誌

Takuma Usuzaki, Ryusei Inamori, Takashi Shizukuishi, Yohei Morishita, Hidenobu Takagi, Mami Ishikuro, Taku Obara, Kei Takase

Magnetic resonance imaging　2024年5月28日

DOI： 10.1016/j.mri.2024.05.012 　

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OBJECTIVES: To evaluate the performance of the multimodal model, termed variable Vision Transformer (vViT), in the task of predicting isocitrate dehydrogenase (IDH) status among adult patients with diffuse glioma. MATERIALS AND METHODS: vViT was designed to predict IDH status using patient characteristics (sex and age), radiomic features, and contrast-enhanced T1-weighted images (CE-T1WI). Radiomic features were extracted from each enhancing tumor (ET), necrotic tumor core (NCR), and peritumoral edematous/infiltrated tissue (ED). CE-T1WI were split into four images and input to vViT. In the training, internal test, and external test, 271 patients with 1070 images (535 IDH wildtype, 535 IDH mutant), 35 patients with 194 images (97 IDH wildtype, 97 IDH mutant), and 291 patients with 872 images (436 IDH wildtype, 436 IDH mutant) were analyzed, respectively. Metrics including accuracy and AUC-ROC were calculated for the internal and external test datasets. Permutation importance analysis combined with the Mann-Whitney U test was performed to compare inputs. RESULTS: For the internal test dataset, vViT correctly predicted IDH status for all patients. For the external test dataset, an accuracy of 0.935 (95% confidence interval; 0.913-0.945) and AUC-ROC of 0.887 (0.798-0.956) were obtained. For both internal and external test datasets, CE-T1WI ET radiomic features and patient characteristics had higher importance than other inputs (p < 0.05). CONCLUSIONS: The vViT has the potential to be a competent model in predicting IDH status among adult patients with diffuse glioma. Our results indicate that age, sex, and CE-T1WI ET radiomic features have key information in estimating IDH status.
右副腎皮質髄質混合腫瘍と左副腎腫瘍によるサブクリニカルクッシング症候群を合併した一例

小林雅幸, 小野美澄, 宍戸愛, 矢浦一磨, 沼畑貴生, 佐藤俊宏, 黒澤聡子, 久保晴丸, 手塚雄太, 尾股慧, 山崎有人, 高瀬圭, 伊藤明宏, 鈴木貴, 片桐秀樹

日本内分泌学会雑誌　100　(1)　341-341　2024年5月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
Screening Cutoff Values for the Detection of Aldosterone-Producing Adenoma by LC-MS/MS and a Novel Noncompetitive CLEIA. 国際誌

Yoshikiyo Ono, Yuta Tezuka, Kei Omata, Ryo Morimoto, Yuto Yamazaki, Sota Oguro, Kei Takase, Akihiro Ito, Tatsunari Yoshimi, Satoshi Kojima, Sadayoshi Ito, Hironobu Sasano, Takashi Suzuki, Tetsuhiro Tanaka, Hideki Katagiri, Fumitoshi Satoh

Journal of the Endocrine Society　8　(6)　bvae080　2024年4月6日

DOI： 10.1210/jendso/bvae080 　

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CONTEXT: Detecting patients with surgically curable aldosterone-producing adenoma (APA) among hypertensive individuals is clinically pivotal. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the ideal method of measuring plasma aldosterone concentration (PAC) because of the inaccuracy of conventional chemiluminescent enzyme immunoassay (CLEIA). However, LC-MS/MS is expensive and requires expertise. We have developed a novel noncompetitive CLEIA (NC-CLEIA) for measuring PAC in 30 minutes. OBJECTIVE: This work aimed to validate NC-CLEIA PAC measurements by comparing them with LC-MS/MS measurements and determining screening cutoffs for both measurements detecting APA. METHODS: We retrospectively measured PAC using LC-MS/MS and NC-CLEIA in 133 patients with APA, 100 with bilateral hyperaldosteronism, and 111 with essential hypertension to explore the accuracy of NC-CLEIA PAC measurements by comparing with LC-MS/MS measurements and determined the cutoffs for detecting APA. RESULTS: Passing-Bablok analysis revealed that the values by NC-CLEIA (the regression slope, intercept, and correlation coefficient were 0.962, -0.043, and 0.994, respectively) were significantly correlated and equivalent to those by LC-MS/MS. Bland-Altman plot analysis of NC-CLEIA and LC-MS/MS also demonstrated smaller systemic errors (a bias of -0.348 ng/dL with limits of agreement of -4.390 and 3.694 within a 95% CI) in NC-CLEIA than LC-MS/MS. The receiver operating characteristic analysis demonstrated that cutoff values for aldosterone/renin activity ratio obtained by LC-MS/MS and NC-CLEIA were 31.2 and 31.5 (ng/dL per ng/mL/hour), with a sensitivity of 91.0% and 90.2% and specificity of 75.4% and 76.8%, respectively, to differentiate APA from non-APA. CONCLUSION: This newly developed NC-CLEIA for measuring PAC could serve as a clinically reliable alternative to LC-MS/MS.
原発性アルドステロン症治療の衆知を集める(最適な治療の解は?) 腹腔鏡下副腎摘除術が原発性アルドステロン症患者のQOL、心機能に与える影響

川崎芳英, 祢津晋久, 手塚ゆうた, 小野美澄, 尾股慧, 小黒草太, 方山博路, 佐竹洋平, 佐藤琢磨, 川守田直樹, 山下慎一, 高瀬圭, 佐藤文俊, 片桐秀樹, 伊藤明宏

日本内分泌外科学会雑誌　41　(Suppl.1)　S136-S136　2024年4月
出版者・発行元： (一社)日本内分泌外科学会
ISSN：2434-6535

eISSN：2758-8785
Identifying key factors for predicting O6-Methylguanine-DNA methyltransferase status in adult patients with diffuse glioma: a multimodal analysis of demographics, radiomics, and MRI by variable Vision Transformer. 国際誌

Takuma Usuzaki, Kengo Takahashi, Ryusei Inamori, Yohei Morishita, Takashi Shizukuishi, Hidenobu Takagi, Mami Ishikuro, Taku Obara, Kei Takase

Neuroradiology　2024年3月12日

DOI： 10.1007/s00234-024-03329-8 　

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PURPOSE: This study aimed to perform multimodal analysis by vision transformer (vViT) in predicting O6-methylguanine-DNA methyl transferase (MGMT) promoter status among adult patients with diffuse glioma using demographics (sex and age), radiomic features, and MRI. METHODS: The training and test datasets contained 122 patients with 1,570 images and 30 patients with 484 images, respectively. The radiomic features were extracted from enhancing tumors (ET), necrotic tumor cores (NCR), and the peritumoral edematous/infiltrated tissues (ED) using contrast-enhanced T1-weighted images (CE-T1WI) and T2-weighted images (T2WI). The vViT had 9 sectors; 1 demographic sector, 6 radiomic sectors (CE-T1WI ET, CE-T1WI NCR, CE-T1WI ED, T2WI ET, T2WI NCR, and T2WI ED), 2 image sectors (CE-T1WI, and T2WI). Accuracy and area under the curve of receiver-operating characteristics (AUC-ROC) were calculated for the test dataset. The performance of vViT was compared with AlexNet, GoogleNet, VGG16, and ResNet by McNemar and Delong test. Permutation importance (PI) analysis with the Mann-Whitney U test was performed. RESULTS: The accuracy was 0.833 (95% confidence interval [95%CI]: 0.714-0.877) and the area under the curve of receiver-operating characteristics was 0.840 (0.650-0.995) in the patient-based analysis. The vViT had higher accuracy than VGG16 and ResNet, and had higher AUC-ROC than GoogleNet (p<0.05). The ED radiomic features extracted from the T2-weighted image demonstrated the highest importance (PI=0.239, 95%CI: 0.237-0.240) among all other sectors (p<0.0001). CONCLUSION: The vViT is a competent deep learning model in predicting MGMT status. The ED radiomic features of the T2-weighted image demonstrated the most dominant contribution.
Investigating the cut-off values of captopril challenge test for primary aldosteronism using the novel chemiluminescent enzyme immunoassay method: a retrospective cohort study. 国際誌

Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kengo Kambara, Hiroki Kamada, Sota Oguro, Yuto Yamazaki, Celso E Gomez-Sanchez, Akihiro Ito, Hironobu Sasano, Kei Takase, Tetsuhiro Tanaka, Hideki Katagiri, Fumitoshi Satoh

Hypertension research : official journal of the Japanese Society of Hypertension　2024年3月8日

DOI： 10.1038/s41440-024-01594-x 　

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The measurement evolution enabled more accurate evaluation of aldosterone production in hypertensive patients. However, the cut-off values for novel assays have been not sufficiently validated. The present study was undertaken to validate the novel chemiluminescent enzyme immunoassay for aldosterone in conjunction with other methods. Moreover, we also aimed to establish a new cut-off value for primary aldosteronism in the captopril challenge test using the novel assay. First, we collected 390 plasma samples, in which aldosterone levels measured using liquid chromatography-mass spectrometry ranged between 0.18 and 1346 ng/dL. The novel chemiluminescent enzyme immunoassay showed identical correlation of plasma aldosterone with liquid chromatography-mass spectrometry, in contrast to conventional radioimmunoassay. Further, we enrolled 299 and 39 patients with primary aldosteronism and essential hypertension, respectively. Plasma aldosterone concentrations measured using the novel assay were lower than those measured by radioimmunoassay, which resulted in decreased aldosterone-to-renin ratios. Subsequently, positive results of the captopril challenge test based on radioimmunoassay turned into "negative" based on the novel assay in 45% patients with primary aldosteronism, using the conventional cut-off value (aldosterone-to-renin activity ratio > 20 ng/dL per ng/mL/h). Receiver operating characteristic curve analysis demonstrated that aldosterone-to-renin activity ratios > 8.2 ng/dL per ng/mL/h in the novel assay was compatible with the conventional diagnosis (sensitivity, 0.874; specificity, 0.980). Our study indicates the great measurement accuracy of the novel chemiluminescent enzyme immunoassay for aldosterone, and the importance of measurement-adjusted cut-offs in the diagnosis of primary aldosteronism.
心臓サルコイドーシス患者の致死的心室不整脈イベント予測における心筋18F-FDG PETの予後予測能(Prognostic Value of Cardiac 18F-fluorodeoxyglucose Positron Emission Tomography in Predicting Fatal Ventricular Arrhythmic Events among Patients with Cardiac Sarcoidosis)

Takeuchi Kouki, Suzuki Hideaki, Takanami Kentaro, Tanaka Yoshitaka, Susukita Kai, Inoue Takumi, Arai Marina, Hayashi Hideka, Nochioka Kotaro, Takahama Hiroyuki, Takase Kei, Yasuda Satoshi

日本循環器学会学術集会抄録集　88回　OE27-7　2024年3月
出版者・発行元： (一社)日本循環器学会
Verification of the effect of data-driven brain motion correction on PET imaging. 国際誌

Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Kazuma Akimoto, Akihito Usui, Hirofumi Kawakami, Akie Katsuki, Nozomu Uetake, Yutaka Dendo, Yoshitaka Tanaka, Hiroyasu Kodama, Kei Takase, Tomohiro Kaneta

PloS one　19　(7)　e0301919　2024年

DOI： 10.1371/journal.pone.0301919 　

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INTRODUCTION: Brain positron emission tomography/computed tomography (PET/CT) scans are useful for identifying the cause of dementia by evaluating glucose metabolism in the brain with F-18-fluorodeoxyglucose or Aβ deposition with F-18-florbetaben. However, since imaging time ranges from 10 to 30 minutes, movements during the examination might result in image artifacts, which interfere with diagnosis. To solve this problem, data-driven brain motion correction (DDBMC) techniques are capable of performing motion corrected reconstruction using highly accurate motion estimates with high temporal resolution. In this study, we investigated the effectiveness of DDBMC techniques on PET/CT images using a Hoffman phantom, involving continuous rotational and tilting motion, each expanded up to approximately 20 degrees. MATERIALS AND METHODS: Listmode imaging was performed using a Hoffman phantom that reproduced rotational and tilting motions of the head. Brain motion correction processing was performed on the obtained data. Reconstructed images with and without brain motion correction processing were compared. Visual evaluations by a nuclear medicine specialist and quantitative parameters of images with correction and reference still images were compared. RESULTS: Normalized Mean Squared Error (NMSE) results demonstrated the effectiveness of DDBMC in compensating for rotational and tilting motions during PET imaging. In Cases 1 and 2 involving rotational motion, NMSE decreased from 0.15-0.2 to approximately 0.01 with DDBMC, indicating a substantial reduction in differences from the reference image across various brain regions. In the Structural Similarity Index (SSIM), DDBMC improved it to above 0.96 Contrast assessment revealed notable improvements with DDBMC. In continuous rotational motion, % contrast increased from 42.4% to 73.5%, In tilting motion, % contrast increased from 52.3% to 64.5%, eliminating significant differences from the static reference image. These findings underscore the efficacy of DDBMC in enhancing image contrast and minimizing motion induced variations across different motion scenarios. CONCLUSIONS: DDBMC processing can effectively compensate for continuous rotational and tilting motion of the head during PET, with motion angles of approximately 20 degrees. However, a significant limitation of this study is the exclusive validation of the proposed method using a Hoffman phantom; its applicability to the human brain has not been investigated. Further research involving human subjects is necessary to assess the generalizability and reliability of the presented motion correction technique in real clinical scenarios.
Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis

Shunji Mugikura, Naoko Mori, Miyeong Gang, Shigenori Kanno, Kazutaka Jin, Shin-Ichiro Osawa, Nobukazu Nakasato, Kei Takase

Journal of Clinical Imaging Science　13　38-38　2023年12月22日
出版者・発行元： Scientific Scholar
DOI： 10.25259/jcis_77_2023 　

ISSN：2156-7514

eISSN：2156-5597

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Objectives: To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides. Material and Methods: Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox. Results: Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions. Conclusion: By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.
Transvenous Radiofrequency Catheter Ablation for an Aldosterone-Producing Tumor of the Left Adrenal Gland: A First in Human Case Report. 国際誌

Sota Oguro, Hideki Ota, Satoru Yanagaki, Masahiro Kawabata, Hiroki Kamada, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Hiroaki Toyama, Kouta Tanimoto, Daisuke Konno, Masanori Yamauchi, Yuki Niwa, Hisao Miyamoto, Kenji Mori, Tetsuhiro Tanaka, Hiroshi Ishihata, Kei Takase

Cardiovascular and interventional radiology　46　(12)　1666-1673　2023年12月

DOI： 10.1007/s00270-023-03584-x 　

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PURPOSE: To describe a novel technique of transvenous radiofrequency catheter ablation of an aldosterone-producing adenoma (APA) of the left adrenal gland using the GOS System (Japan Lifeline, Tokyo, Japan). Using the GOS system, a flexible radiofrequency tip catheter can be inserted into the adrenal central and tributary veins, the drainers for functional tumors. MATERIALS AND METHODS: An APA at the left adrenal gland, which was diagnosed by segmental adrenal venous sampling following administration of 0.25 mg cosyntropin, was ablated using the GOS catheter inserted into adrenal tributary veins via a right femoral vein 7-Fr sheath. The effect of radiofrequency ablation on APA was assessed using the international consensus on surgical outcomes for unilateral primary aldosteronism (PA). RESULTS: No device-related complications were observed. The patient was deeply sedated under blood pressure and heart rate control with continuous administration of β-blockers. Then, the tumor and surrounding adrenal gland were cauterized at 7000 J two times each in sequence. The output time was 7-11 min for each ablation and 80 min in total. For blood pressure and pulse rate control, esmolol hydrochloride and phentolamine mesylate were used. The contrast enhancement of APA disappeared on dynamic CT immediately after the procedure. PA was biochemically cured until 12 months after the procedure. CONCLUSION: Using the radiofrequency device with the GOS catheter and system is a method for cauterizing adrenal tumors from blood vessels. This approach resulted in a marked reduction in aldosterone concentrations and a complete biochemical cure of PA over the observation period.
A case of percutaneous transhepatic portal vein stenting without using iodinated contrast media for post pancreatectomy portal vein obstruction. 国際誌

Hinano Anaba, Sota Oguro, Hideki Ota, Satoru Yanagaki, Tomomi Sato, Kei Nakagawa, Michiaki Unno, Kei Takase

BJR case reports　9　(6)　20220116-20220116　2023年11月

DOI： 10.1259/bjrcr.20220116 　

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Postoperative portal vein obstruction could occur as a complication of portal vein reconstruction during hepatic lobectomy or pancreaticoduodenectomy. We report a case of patient with postoperative portal vein obstruction treated with percutaneous transhepatic portal vein stenting without using iodinated contrast media owing to a history of severe allergic reactions. Under ultrasound guidance, carbon dioxide angiography, and appropriate device selection, successful stenting was achieved without serious adverse events. After the operation, portal vein blood flow and clinical symptoms improved, enabling adjuvant chemotherapy. To the best of our knowledge, this is the first case report wherein percutaneous transhepatic portal vein stenting was successfully performed in a patient with an iodine allergy.
「ACSにおける画像診断/Imaging in Acute care surgery」 Hybrid ERでCTに基づいたacute care surgeryを遂行するには放射線部の協力が必要である

谷河篤, 藤田基生, 小野勝範, 勝田賢, 大田英揮, 高瀬圭, 久志本成樹

Japanese Journal of Acute Care Surgery　13　(Suppl.)　95-95　2023年10月
出版者・発行元： (一社)日本Acute Care Surgery学会
eISSN：2436-102X
アキシャル加算平均画像を用いた胸部単純CT検査におけるSize-Specific Dose Estimatesの有用性

田頭豊, 安部圭亮, 小野寺崇, 茅野伸吾, 大田英揮, 高瀬圭

日本放射線技術学会雑誌　79　(9)　1038-1038　2023年9月
出版者・発行元： (公社)日本放射線技術学会
ISSN：0369-4305

eISSN：1881-4883
Size-Specific Dose Estimatesと撮影長による新たな実効線量換算係数の考案

安部圭亮, 田頭豊, 小野寺崇, 茅野伸吾, 大田英揮, 高瀬圭

日本放射線技術学会雑誌　79　(9)　1102-1102　2023年9月
出版者・発行元： (公社)日本放射線技術学会
ISSN：0369-4305

eISSN：1881-4883
MRI画像の前立腺癌セグメンテーションにおけるマルチシーケンス画像を用いたDeep Learningの有用性

村上弘晃, 河端真広, 高屋英知, 小林智哉, 大田英揮, 高瀬圭, 植田琢也

日本放射線技術学会雑誌　79　(9)　1075-1075　2023年9月
出版者・発行元： (公社)日本放射線技術学会
ISSN：0369-4305

eISSN：1881-4883
Role of Magnetic Resonance Imaging in the Screening of Closed Spinal Dysraphism.

Hidekazu Aoki, Shunji Mugikura, Reizo Shirane, Toshiaki Hayashi, Tomomi Kimiwada, Kiyohide Sakai, Keiko Ainoya, Hideki Ota, Kei Takase, Yoshihisa Shimanuki

Neurologia medico-chirurgica　2023年8月30日

DOI： 10.2176/jns-nmc.2023-0002 　

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Closed spinal dysraphism (CSD) encompasses a heterogeneous group of spinal cord deformities, which can be accompanied by several types of skin stigmata. These skin stigmata may include inconspicuous features, such as sacral dimples and deformed gluteal clefts, but the association between such mild skin stigmata and CSD is uncertain. This study aimed to reevaluate the indication for magnetic resonance imaging (MRI) in patients with skin stigmata while considering the indication for surgery. A retrospective analysis was conducted on magnetic resonance images of 1255 asymptomatic children with skin stigmata between 2003 and 2015. Skin stigmata classification was based on medical chart data. All subtypes of CSDs except for filum terminale lipomas (FTL), FTL thicker than 2 mm or with low conus medullaris, were considered to meet the surgical indication. CSD prevalence was estimated while considering the surgical indications and assessed after excluding all FTL cases. Skin stigmata were classified into seven types, dimple, deformed gluteal cleft, hair, subcutaneous mass, appendage, discoloration, and protruding bone, and included 1056 isolated and 199 complex ones. The prevalence of CSD was 19.5%, 6.8%, and 0.5% among patients with isolated dimples (n = 881) and 13.9%, 5.8%, and 0.7% among those with isolated deformed gluteal clefts (n = 136) for all cases, surgical indications, and patients without FTL, respectively. Dimples and deformed gluteal clefts had a low prevalence of CSD requiring surgical intervention, and cases without FTL were rare. Asymptomatic patients with mild skin stigmata may not require immediate MRI.
Utility of Carbon Dioxide Venography and Intraprocedural CT for Adrenal Venous Sampling in Patients with an Allergy to Iodinated Contrast Media. 国際誌

Hiroki Kamada, Kazumasa Seiji, Sota Oguro, Hideki Ota, Satoru Yanagaki, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

Journal of vascular and interventional radiology : JVIR　2023年7月31日

DOI： 10.1016/j.jvir.2023.07.021 　

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PURPOSE: To assess the diagnostic performance of carbon dioxide (CO2) and intraprocedural unenhanced computed tomography (CT) for adrenal venous sampling (AVS) (CO2-intraprocedural unenhanced CT-AVS) in patients with primary aldosteronism (PA) and a history of iodine contrast medium allergy. MATERIALS AND METHODS: CO2-intraprocedural unenhanced CT-AVS was performed in 18 patients with iodine contrast media allergies at the authors' hospital between December 2015 and January 2021. CT and noncontrast magnetic resonance angiography were used to evaluate the preoperative adrenal vein anatomy. CO2 venography was performed to confirm adrenal vein catheterization. Additionally, intraprocedural unenhanced CT was also performed to confirm catheter position in the right adrenal gland. RESULTS: In all cases in which CO2-intraprocedural unenhanced CT-AVS was performed, the right and left adrenal veins were catheterized appropriately, leading to a localized diagnosis. Catheterization of the left adrenal vein was confirmed using CO2 venography in all cases. In 7 of the 18 cases, CO2 venography demonstrated selection of the right adrenal vein. In 15 of 18 cases, intraprocedural unenhanced CT demonstrated selection of the right adrenal vein. CONCLUSIONS: CO2-intraprocedural unenhanced CT-AVS demonstrated the same diagnostic ability for PA localization as conventional AVS with iodine contrast media. The proposed method is clinically feasible for AVS, in which iodine contrast media use is restricted.
Type 2 Endoleak Detection After Endovascular Aneurysm Repair: Can Low-Flow Endoleaks Also Be Visualized in Silicon-Photomultiplier-Based Positron Emission Tomography/Computed Tomography Scans? 国際誌

Ayaka Harigai, Yoshitaka Toyama, Michihisa Umetsu, Kentaro Takanami, Kei Takase

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists　15266028231185237-15266028231185237　2023年7月2日

DOI： 10.1177/15266028231185237 　

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PURPOSE: To present a novel clinical application of silicon-photomultiplier-based positron emission tomography (SiPM-based PET)/computed tomography (CT), detecting a type II endoleak 5 years after endovascular aneurysm repair (EVAR). TECHNIQUE: SiPM-based PET/CT scans with a standard whole-body protocol were performed for a 73-year-old man with a past medical history of abdominal aortic aneurysms treated with EVAR and currently under investigation of his duodenal papillary carcinoma. The PET/CT demonstrated 18F-fluorodeoxyglucose (FDG) accumulation outside the stent graft in the native sac of the aneurysm. The site of accumulation corresponded to that of the contrast enhancement depicted in the CT angiography taken 1 month earlier. Another CT scan performed 3 months later revealed enlargement of the aneurysm. CONCLUSION: SiPM-based PET/CT, with its superior sensitivity and spatial resolution over conventional PET/CT, can detect type II low-flow endoleaks. CLINICAL IMPACT: Abnormal intra-aneurysmal FDG activity incidentally detected on SiPM-based PET/CT is worthy of attention because it may be indicative of endoleaks. Additional imaging using different modalities should be considered so that the patient would not miss the additional treatment opportunity upon observing sac enlargement. For patients with contraindications for iodine CT contrast media, SiPM-based PET/CT would serve as a suitable alternative.
Clinical impact of radiation-induced myocardial damage detected by cardiac magnetic resonance imaging and dose-volume histogram parameters of the left ventricle as prognostic factors of cardiac events after chemoradiotherapy for esophageal cancer. 国際誌

Rei Umezawa, Hideki Ota, Hidenobu Takagi, Noriyuki Kadoya, Yujiro Nakajima, Noriyoshi Takahashi, Takaya Yamamoto, Kei Takase, Keiichi Jingu

Journal of radiation research　64　(4)　702-710　2023年6月12日

DOI： 10.1093/jrr/rrad040 　

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This prospective study aimed to evaluate whether radiation (RT)-induced myocardial damage by cardiac magnetic resonance (CMR) imaging could be a predictor of cardiac events after chemoradiotherapy (CRT) for esophageal cancer and determine the dose-volume histogram (DVH) parameters of the left ventricle (LV) in predicting cardiac events. CMR imaging was performed before and 6 months after CRT in patients receiving definitive CRT. RT-induced myocardial damage was defined as abnormal CMR findings indicating myocardial fibrosis corresponding to an isodose line of ≥30 Gy. The cutoff values of the LV DVH parameters were calculated using the receiver operating characteristic curve based on the presence of RT-induced myocardial damage. The prognostic factors related to cardiac events of Grade 3 or higher were examined. Twenty-three patients were enrolled in the study. RT-induced myocardial damage by late gadolinium enhancement and/or an increase of 100 ms or higher in native T1 post-CRT was detected in 10 of the 23 patients. LV V45 was the best predictive factor for RT-induced myocardial damage with a cutoff value of 2.1% and an area under the curve of 0.75. The median follow-up period was 82.1 months. The 5- and 7-year cumulative incidences of cardiac events of Grade 3 or higher were 14.7 and 22.4%, respectively. RT-induced myocardial damage and LV V45 were significant risk factors (P = 0.015 and P = 0.013, respectively). RT-induced myocardial damage is a significant predictor of cardiac events. LV V45 is associated with RT-induced myocardial damage and subsequent cardiac events.
Erratum to "Carotid computed tomography angiography after cobalt-based alloy carotid artery stenting using ultra-high-resolution computed tomography with model-based iterative reconstruction" [Radiol Case Rep 2021;16:3721-8]. 国際誌

Shingo Kayano, Hideki Ota, Yoshimichi Sato, Toshiki Endo, Kuniyasu Niizuma, Ichiro Suzuki, Tsuyoshi Kawamura, Kei Takase

Radiology case reports　18　(6)　2324-2324　2023年6月

DOI： 10.1016/j.radcr.2023.03.021 　

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[This corrects the article DOI: 10.1016/j.radcr.2021.09.003.].
Improvement of Imaging Conditions to Improve the Detection Rate of Head and Neck Cancer by Positron Emission Tomography/Computed Tomography Examination. 査読有り

Hayato Odagiri, Kentaro Takanami, Tomohiro Kaneta, Akihito Usui, Ikuho Kojima, Hiroyasu Kodama, Shin Saitou, Yoshitaka Tanaka, Yutaka Dendo, Kei Takase

The Tohoku journal of experimental medicine　260　(2)　141-147　2023年5月30日

DOI： 10.1620/tjem.2023.J026 　

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Positron emission tomography (PET)/computed tomography (CT) has improved sensitivity and resolution using silicon photomultiplier as a photosensor. Previously, only a fixed setting was available for the shooting time of 1 bed, but now, the shooting time can be changed for each bed. Time can be shortened or extended depending on the target area. A few studies reported on image reconstruction conditions for head and neck cancer in whole-body PET/CT examinations. Thus, this study aimed to optimize the imaging conditions of the head and neck region during whole-body imaging. A cylindrical acrylic container with a 200 mm diameter was used to simulate the head and neck area using a PET/CT system equipped with a semiconductor detector. Spheres of 6-30 mm in diameter were enclosed in the 200 mm diameter cylindrical acrylic vessel. Radioactivity in 18F solution (Hot:BG ratio 4:1) was enclosed in a phantom following the Japanese Society of Nuclear Medicine (JSNM) guidelines. Background radioactivity concentration was 2.53 kBq/mL. List mode acquisition of 1,800 s was collected at 60-1,800 s with the field of view of 700 mm and 350 mm. The image was reconstructed by resizing the matrix to 128 × 128, 192 × 192, 256 × 256, and 384 × 384, respectively. The imaging time per bed in the head and neck should be at least 180 s, and the reconstruction conditions should be a field of view (FOV) of 350 mm, matrix sizes of ≥ 192, and a Bayesian penalized likelihood (BPL) reconstruction with a β-value of 200. This allows detection of > 70% of the 8-mm spheres in the images.
保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 大田英揮

日本内分泌学会雑誌　99　(1)　317-317　2023年5月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
経静脈的アブレーションによる原発性アルドステロン症の治療 First-in-Human

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 榊原宏幸, 大田英揮

日本内分泌学会雑誌　99　(1)　317-317　2023年5月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 大田英揮

日本内分泌学会雑誌　99　(1)　317-317　2023年5月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
経静脈的アブレーションによる原発性アルドステロン症の治療 First-in-Human

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 榊原宏幸, 大田英揮

日本内分泌学会雑誌　99　(1)　317-317　2023年5月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
無症候性の閉鎖性脊椎癒合不全のスクリーニングにおけるMRIの役割

青木英和, 麦倉俊司, 白根礼造, 林俊哲, 君和田友美, 坂井清英, 相野谷慶子, 大田英揮, 高瀬圭, 島貫義久

日本小児放射線学会雑誌　39　(Suppl.)　35-35　2023年5月
出版者・発行元： (一社)日本小児放射線学会
ISSN：0918-8487

eISSN：2432-4388
High-flow arteriovenous malformation in the finger with transvenous ethanolamine oleate sclerotherapy using an arterial tourniquet and microballoon occlusion: A case report

Hiromitsu Tannai, Sota Oguro, Munetomo Nagao, Hideki Ota, Kei Takase

Radiology Case Reports　18　(5)　1973-1977　2023年5月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.radcr.2023.02.048 　

ISSN：1930-0433
18 F-FDG PET/CT Imaging Post Heart Transplantation Depicts High Accumulation at Sites of Previous Ventricular Assist Device Insertion. 国際誌

Yoshitaka Toyama, Masayuki Otani, Nobuhiro Yaoita, Kentaro Takanami, Kei Takase

Clinical nuclear medicine　48　(4)　366-369　2023年4月1日

DOI： 10.1097/RLU.0000000000004580 　

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A 37-year-old man with previous heart transplantation for dilated cardiomyopathy underwent screening for malignancy under posttransplantation immunosuppression. 18 F-FDG PET/CT revealed uptake in 2 peritoneal sites of the pericardium that corresponded to the insertion sites of a left ventricular assist device that was used before transplantation. Additional abnormal uptake in the right axillary artery, aortic arch, and left femoral artery corresponded to the insertion sites for arterial inflow during cardiopulmonary bypass. Knowledge that FDG accumulation may occur at the insertion sites of an extracorporeal-circulation device enables unnecessary tests to be avoided.
Principal component analysis of texture features for grading of meningioma: not effective from the peritumoral area but effective from the tumor area. 国際誌

Naoko Mori, Shunji Mugikura, Toshiki Endo, Hidenori Endo, Yo Oguma, Li Li, Akira Ito, Mika Watanabe, Masayuki Kanamori, Teiji Tominaga, Kei Takase

Neuroradiology　65　(2)　257-274　2023年2月

DOI： 10.1007/s00234-022-03045-1 　

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PURPOSE: To investigate whether texture features from tumor and peritumoral areas based on sequence combinations can differentiate between low- and non-low-grade meningiomas. METHODS: Consecutive patients diagnosed with meningioma by surgery (77 low-grade and 28 non-low-grade meningiomas) underwent preoperative magnetic resonance imaging including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast-enhanced T1WI (CE-T1WI). Manual segmentation of the tumor area was performed to extract texture features. Segmentation of the peritumoral area was performed for peritumoral high-signal intensity (PHSI) on T2WI. Principal component analysis was performed to fuse the texture features to principal components (PCs), and PCs of each sequence of the tumor and peritumoral areas were compared between low- and non-low-grade meningiomas. Only PCs with statistical significance were used for the model construction using a support vector machine algorithm. k-fold cross-validation with receiver operating characteristic curve analysis was used to evaluate diagnostic performance. RESULTS: Two, one, and three PCs of T1WI, apparent diffusion coefficient (ADC), and CE-T1WI, respectively, for the tumor area, were significantly different between low- and non-low-grade meningiomas, while PCs of T2WI for the tumor area and PCs for the peritumoral area were not. No significant differences were observed in PHSI. Among models of sequence combination, the model with PCs of ADC and CE-T1WI for the tumor area showed the highest area under the curve (0.84). CONCLUSION: The model with PCs of ADC and CE-T1WI for the tumor area showed the highest diagnostic performance for differentiating between low- and non-low-grade meningiomas. Neither PHSI nor PCs in the peritumoral area showed added value.
Individualized risk assessment of recanalization of visceral aneurysms using stagnation of intra-aneurysmal flow

Hiroki Kamada, Masanori Nakamura, Hideki Ota, Sota Oguro, Satoshi Higuchi, Tomomi Sato, Kei Takase

Journal of Biorheology　37　(2)　73-82　2023年
出版者・発行元： Japanese Society of Biorheology
DOI： 10.17106/jbr.37.73 　

ISSN：1867-0466

eISSN：1867-0474
Bipolar Radiofrequency Ablation of the Adrenal Gland: <i>In Vivo</i> and <i>Ex Vivo</i> Experiments

Tomo Kinoshita, Kazumasa Seiji, Sota Oguro, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

The Tohoku Journal of Experimental Medicine　259　(2)　127-133　2023年
出版者・発行元： Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j110 　

ISSN：0040-8727

eISSN：1349-3329
Clinical impact of cardiac magnetic resonance in patients with suspected coronary artery disease associated with chronic kidney disease (AQUAMARINE-CKD study): study protocol for a randomized controlled trial

Teruo Noguchi, Hideki Ota, Naoya Matsumoto, Yoshiaki Morita, Akira Oshita, Eiji Kawasaki, Tomohiro Kawasaki, Kensuke Moriwaki, Shingo Kato, Kazuki Fukui, Tomoya Hoshi, Hiroaki Watabe, Tomoaki Kanaya, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Kensuke Takagi, Shuichi Yoneda, Kenichiro Sawada, Takamasa Iwai, Hideo Matama, Satoshi Honda, Masashi Fujino, Hiroyuki Miura, Kunihiro Nishimura, Kei Takase

Trials　23　(1)　2022年12月

DOI： 10.1186/s13063-022-06820-w 　

eISSN：1745-6215
Blood flow analysis with computational fluid dynamics and 4D-flow MRI for vascular diseases. 国際誌

Hiroki Kamada, Masanori Nakamura, Hideki Ota, Satoshi Higuchi, Kei Takase

Journal of cardiology　80　(5)　386-396　2022年11月

DOI： 10.1016/j.jjcc.2022.05.007 　

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Both computational fluid dynamics (CFD) and time-resolved, three-dimensional, phase-contrast, magnetic resonance imaging (4D-flow MRI) enable visualization of time-varying blood flow structures and quantification of blood flow in vascular diseases. However, they are totally different. CFD is a method to calculate blood flow by solving the governing equations of fluid mechanics, so the obtained flow field is somewhat virtual. On the other hand, 4D-flow MRI measures blood flow in vivo, thus the flow is real. Recently, with the development and enhancement of computers, medical imaging techniques, and related software, blood flow analysis has become more accessible to clinicians and its usefulness in vascular diseases has been demonstrated. In this review, we have outlined the methods and characteristics of CFD and 4D-flow MRI, respectively. We have discussed the differences in the characteristics between both methods; reviewed the milestones achieved by blood flow analysis in various vascular diseases; and discussed the usefulness, challenges, and limitations of blood flow analysis. We have discussed the difficulties and limitations of current blood flow analysis. We have also discussed our views on future directions.
慢性大動脈解離症例における選択的真腔血管内造影CT検査を用いたAdamkiewicz動脈の同定

大谷将之, 伊藤校輝, 樋口慧, 板垣皓大, 武富龍一, 前田恵, 鈴木佑輔, 鈴木智之, 片平晋太郎, 高橋悟朗, 熊谷紀一郎, 大田英揮, 高瀬圭, 齋木佳克

日本胸部外科学会定期学術集会　75回　CCPA1-6　2022年10月
出版者・発行元： (一社)日本胸部外科学会
Usefulness of maximum intensity projection images of non-enhanced CT for detection of hyperdense middle cerebral artery sign in acute thromboembolic ischemic stroke

Sota Oguro, Shunji Mugikura, Hideki Ota, Seiji Bito, Yuta Asami, Wataru Sotome, Yoshiaki Ito, Hideki Kaneko, Kazuyo Suzuki, Nobuya Higuchi, Kei Takase

Japanese Journal of Radiology　40　(10)　1046-1052　2022年10月

DOI： 10.1007/s11604-022-01289-8 　

ISSN：1867-1071

eISSN：1867-108X
Usefulness of cardiac magnetic resonance for early detection of cancer therapeutics-related cardiac dysfunction in breast cancer patients. 国際誌

Yosuke Terui, Koichiro Sugimura, Hideki Ota, Hiroshi Tada, Kotaro Nochioka, Haruka Sato, Yuko Katsuta, Junko Fujiwara, Narumi Harada-Shoji, Akiko Sato-Tadano, Yoshiaki Morita, Wenyu Sun, Satoshi Higuchi, Shunsuke Tatebe, Shigefumi Fukui, Saori Miyamichi-Yamamoto, Hideaki Suzuki, Nobuhiro Yaoita, Nobuhiro Kikuchi, Miku Sakota, Satoshi Miyata, Yasuhiko Sakata, Takanori Ishida, Kei Takase, Satoshi Yasuda, Hiroaki Shimokawa

International journal of cardiology　371　472-479　2022年9月14日

DOI： 10.1016/j.ijcard.2022.09.025 　

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BACKGROUND: Prognosis of breast cancer patients has been improved along with the progress in cancer therapies. However, cancer therapeutics-related cardiac dysfunction (CTRCD) has been an emerging issue. For early detection of CTRCD, we examined whether native T1 mapping and global longitudinal strain (GLS) using cardiac magnetic resonance (CMR) and biomarkers analysis are useful. METHODS: We prospectively enrolled 83 consecutive chemotherapy-naïve female patients with breast cancer (mean age, 56 ± 13 yrs.) between 2017 and 2020. CTRCD was defined based on echocardiography as left ventricular ejection fraction (LVEF) below 53% at any follow-up period with LVEF>10% points decrease from baseline after chemotherapy. To evaluate cardiac function, CMR (at baseline and 6 months), 12‑lead ECG, echocardiography, and biomarkers (at baseline and every 3 months) were evaluated. RESULTS: A total of 164 CMRs were performed in 83 patients. LVEF and GLS were significantly decreased after chemotherapy (LVEF, from 71.2 ± 4.4 to 67.6 ± 5.8%; GLS, from -27.9 ± 3.9 to -24.7 ± 3.5%, respectively, both P < 0.01). Native T1 value also significantly elevated after chemotherapy (from 1283 ± 36 to 1308 ± 39 msec, P < 0.01). Among the 83 patients, 7 (8.4%) developed CTRCD. Of note, native T1 value before chemotherapy was significantly higher in patients with CTRCD than in those without it (1352 ± 29 vs. 1278 ± 30 msec, P < 0.01). The multivariable logistic regression analysis revealed that native T1 value was an independent predictive factor for the development of CTRCD [OR 2.33; 95%CI 1.15-4.75, P = 0.02]. CONCLUSIONS: These results indicate that CMR is useful to detect chemotherapy-related myocardial damage and predict for the development of CTRCD in breast cancer patients.
Safety and feasibility of radiofrequency ablation using bipolar electrodes for aldosterone-producing adenoma: a multicentric prospective clinical study. 国際誌

Sota Oguro, Ryo Morimoto, Kazumasa Seiji, Hideki Ota, Tomo Kinoshita, Masahiro Kawabata, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Fumitoshi Satoh, Sadayoshi Ito, Nobukazu Moriya, Seishi Matsui, Tetsuo Nishikawa, Masao Omura, Kazuki Nakai, Seishi Nakatsuka, Isao Kurihara, Kazutoshi Miyashita, Wataru Koda, Tetsuya Minami, Yoshiyu Takeda, Mitsuhiro Kometani, Yutaka Oki, Toshihiro Oishi, Takasuke Ushio, Satoshi Goshima, Kei Takase

Scientific reports　12　(1)　14090-14090　2022年8月18日

DOI： 10.1038/s41598-022-18136-5 　

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Evaluation of feasibility and safety of percutaneous radiofrequency ablation using bipolar radiofrequency devices in a prospective multicenter cohort of patients with benign aldosterone-producing adenoma. A total of five institutions participated. CT-guided percutaneous RFA was performed for patients diagnosed as APA. The safety of the procedure was evaluated using the Common Terminology Criteria for Adverse Events. During the 84-day follow-up period, serial changes in plasma aldosterone concentration and plasma renin activity were measured. The percentage of patients with normalized hormonal activity after the procedure, was calculated with 95% confidence intervals. Forty patients were enrolled, and two patients were excluded for cerebral hemorrhage and no safe puncture root. In another patients, RFA was tried, but an intraprocedural intercostal arterial injury occurred. Consequently, RFA was completed in thirty-seven patients (20 men, 17 women; mean age, 50.4 ± 10.0 year). The tumor size was 14.8 ± 3.8 mm. The treatment success rate of the ablation was 94.6% (35/37), and a 2nd session was performed in 2.7% (1/37) patients. Grade 4 adverse events were observed in 4 out of 38 sessions (10.5%). The normalization of plasma aldosterone concentration or aldosterone-renin ratio was 86.5% (72.0-94.1: 95% confidence interval) on day 84. Percutaneous CT-guided RFA for APA using a bipolar radiofrequency system was safe and feasible with clinical success rate of 86.5% on day 84.
Transvenous Radiofrequency Ablation of Adrenal Gland: Experimental Study. 国際誌

Hiroyuki Sakakibara, Kazumasa Seiji, Sota Oguro, Kenji Mori, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Takuya Masuda, Hisao Miyamoto, Takuya Hirao, Yuki Niwa, Yohei Suzuki, Yasutaka Baba, Fumitoshi Satoh, Kei Takase

Cardiovascular and interventional radiology　45　(8)　1178-1185　2022年8月

DOI： 10.1007/s00270-022-03155-6 　

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PURPOSE: The aim was to evaluate a flexible device for transvenous adrenal gland radiofrequency ablation in vitro and in an in vivo animal model. MATERIALS AND METHODS: A flexible radiofrequency-tip catheter with an inner-cooling mechanism and a guidewire lumen was made. Then, using a polyvinyl alcohol gel model, the ablation diameter was evaluated and how much energy to deliver in vivo was determined. Finally, transvenous radiofrequency ablation of the left adrenal glands of two pigs was performed, delivering 5000 or 7000 J in a single dose to each. The ablation effects were also assessed by histological examination of hematoxylin-eosin-stained sections. RESULTS: The mean ablation diameters in the gel model were 20.2 and 21.9 mm in the short axis and 15 and 20 mm in the long axis for 5000 or 7000 J, respectively. The device was inserted into porcine left adrenal vein with no complications. The mean ablation diameters were 10 mm in the shorter axis (whole thickness of porcine left adrenal gland) in the porcine model for 7000 J. Transient increases in blood pressure and heart rate occurred during ablation. Histologically, the adrenal gland showed severe necrosis at ablated area. There was venous congestion upstream in a non-ablated area, and thermal damage to surrounding organs was not observed. CONCLUSIONS: A flexible radiofrequency-tip catheter could be inserted successfully into the left adrenal vein. The left adrenal gland was entirely ablated without any thermal damage to surrounding organs. We suggest transvenous adrenal ablation has potential as a therapeutic option for primary aldosteronism.
【アルドステロンをめぐる臨床課題】原発性アルドステロン症治療におけるラジオ波治療の意義

柳垣聡, 小黒草太, 清治和将, 高瀬圭, 尾股慧, 手塚雄太, 小野美澄, 森本玲, 田中哲洋, 佐藤文俊

糖尿病・内分泌代謝科　55　(2)　204-209　2022年8月
出版者・発行元： (有)科学評論社
ISSN：2435-1946
Multimodal imaging findings including high-resolution 3D T2-weighted imaging for COVID-19 vaccine-associated axillary lymphadenopathy in a patient with breast cancer

Hiroaki Shimizu, Naoko Mori, Hainan Ren, Minoru Miyashita, Satoko Sato, Shunji Mugikura, Kei Takase

Radiology Case Reports　17　(8)　2831-2836　2022年8月

DOI： 10.1016/j.radcr.2022.04.044 　

eISSN：1930-0433
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging

Naoko Mori, Chihiro Inoue, Hajime Tamura, Tatsuo Nagasaka, Hainan Ren, Satoko Sato, Yu Mori, Minoru Miyashita, Shunji Mugikura, Kei Takase

Magnetic Resonance Imaging　90　53-60　2022年7月

DOI： 10.1016/j.mri.2022.04.003 　

ISSN：0730-725X

eISSN：1873-5894
Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment

Simon Tupin, Kei Takase, Makoto Ohta

Fluids　7　(7)　220-220　2022年6月30日
出版者・発行元： MDPI AG
DOI： 10.3390/fluids7070220 　

eISSN：2311-5521

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Decades after its introduction, endovascular aneurysm repair remains a challenging procedure with risks of collateral patency failure. Here, we investigate the ability of a porous stent, the Multilayer Flow Modulator (MFM), to maintain renal perfusion after a single or overlapping case. Silicone models representing an ideal infrarenal AAA geometry were used to analyze and compare three cases (control, single MFM and two overlapped MFMs). Micro-computed tomography was used to image the deployed MFM devices geometry and evaluate pore size and density along with porosity in both two (planimetric) and three dimensions (gravimetric). Laser particle image velocimetry (PIV) experiments were performed to image velocity and vorticity fields at the aorta-renal bifurcation. Flow experiments revealed renal arteries perfusion preservation in both single and overlapped cases. Microstructure analysis revealed an uneven distribution of wires in the MFM devices leading to local change in planimetric porosity and pore size. Overlap of a second MFM device led to a significant decrease in those 2D metrics but did not affect the gravimetric porosity and the branch perfusion. This first microstructure evaluation of MFM device combined with flow experiments revealed the ability of the device to preserve collateral flow thanks to a highly porous microstructure.
The role of magnetic resonance imaging in prostate cancer patients on active surveillance

Naoko Mori, Shunji Mugikura, Kei Takase

The British Journal of Radiology　96　(1151)　20220140　2022年5月23日

DOI： 10.1259/bjr.20220140 　

eISSN：1748-880X
Update on the roles of imaging in the management of chronic thromboembolic pulmonary hypertension. 国際誌

Satoshi Higuchi, Hideki Ota, Nobuhiro Yaoita, Hiroki Kamada, Hidenobu Takagi, Taiju Sato, Satoshi Yasuda, Kei Takase

Journal of cardiology　81　(3)　297-306　2022年4月27日

DOI： 10.1016/j.jjcc.2022.03.001 　

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Chronic thromboembolic pulmonary hypertension (CTEPH), classified as group 4 pulmonary hypertension (PH), is caused by stenosis and obstruction of the pulmonary arteries by organized thrombi that are incompletely resolved after acute pulmonary embolism. The prognosis of patients with CTEPH is poor if untreated; however, in expert centers with multidisciplinary teams, a treatment strategy for CTEPH has been established, dramatically improving its prognosis. CTEPH is currently not a fatal disease and is the only curable form of PH. Despite these advances and the establishment of treatment approaches, early diagnosis is still challenging, especially for non-experts, for several reasons. One of the reasons for this is insufficient knowledge of the various diagnostic imaging modalities, which are essential in the clinical practice of CTEPH. Imaging modalities should detect the following pathological findings: lung perfusion defects, thromboembolic lesions in pulmonary arteries, and right ventricular remodeling and dysfunction. Perfusion lung scintigraphy and catheter angiography have long been considered gold standards for the detection of perfusion defects and assessment of vascular lesions, respectively. However, advances in imaging technology of computed tomography and magnetic resonance imaging have enabled the non-invasive detection of these abnormal findings in a single examination. Cardiac magnetic resonance (CMR) is the gold standard for evaluating the morphology and function of the right heart; however, state-of-the-art techniques in CMR allow the assessment of cardiac tissue characterization and hemodynamics in the pulmonary arteries. Comprehensive knowledge of the role of imaging in CTEPH enables appropriate use of imaging modalities and accurate image interpretation, resulting in early diagnosis, determination of treatment strategies, and appropriate evaluation of treatment efficacy. This review summarizes the current roles of imaging in the clinical practice for CTEPH, demonstrating the characteristic findings observed in each modality.
新規測定法によるアルドステロン症診断と高血圧症診療の精緻化

佐藤文俊, 小野美澄, 手塚雄太, 尾股慧, 山崎有人, 森本玲, 高瀬圭, 田中哲洋, 笹野公伸, 小島哲

日本内分泌学会雑誌　98　(1)　214-214　2022年4月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
Clinical Application of 4D Flow MR Imaging to Pulmonary Hypertension.

Hideki Ota, Hiroki Kamada, Satoshi Higuchi, Kei Takase

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　21　(2)　309-318　2022年3月1日

DOI： 10.2463/mrms.rev.2021-0111 　

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Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure (PAP). Although right-heart catheterization is the gold standard method for the diagnosis of PH by definition, various less-invasive imaging tests have been used for screening, detection of underlying diseases-causing PH, and monitoring of diseases. Among them, 4D flow MRI is an emerging and unique imaging test that allows for comprehensive visualization of blood flow in the right heart and proximal pulmonary arteries. The characteristic blood flow pattern observed in patients with PH is vortical flow formation in the main pulmonary artery. Recent studies have proposed the use of these findings to determine not only the presence of PH but also estimate the mean PAP. Other applications of 4D flow MRI for PH include measurement of wall shear stress, helicity, and 3D flow balance in the pulmonary arteries. It is worth noting that 4D flow has also the potential for longitudinal follow-ups. In this review, the clinical definition of PH, summary of conventional imaging tests, characteristics of pulmonary arterial flow as shown by 4D flow MRI, and clinical application of 4D flow MRI in the management of patients with PH will be discussed.
Novel technique for recanalization of severe hepaticojejunal obstruction using a transseptal needle in a pediatric liver transplant recipient

Kengo Sasaki, Hideki Ota, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Yoshikatsu Saitoh, Norifumi Kanai, Hiroyasu Nishimaki, Kei Takase, Michiaki Unno, Takashi Kamei

Pediatric Transplantation　26　(2)　2022年3月

DOI： 10.1111/petr.14160 　

ISSN：1397-3142

eISSN：1399-3046
Quantification of vortex flow in pulmonary arteries of patients with chronic thromboembolic pulmonary hypertension

Hiroki Kamada, Hideki Ota, Masanori Nakamura, Wenyu Sun, Tatsuo Aoki, Haruka Sato, Koichiro Sugimura, Kei Takase

European Journal of Radiology　148　2022年3月

DOI： 10.1016/j.ejrad.2021.110142 　

ISSN：0720-048X

eISSN：1872-7727
Grading of placental accrete spectrum using texture analysis of magnetic resonance imaging. 国際誌

Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

Clinical imaging　85　8-9　2022年2月22日

DOI： 10.1016/j.clinimag.2022.02.018 　
関節リウマチ薬物治療効果判定に有効な手関節ダイナミックMRIのパラメータ検証

森菜緒子, 常陸真, 麦倉俊司, 高瀬圭, 森優, 井上麻美

Japanese Journal of Radiology　40　(Suppl.)　5-5　2022年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
Letter to the editor on "High signal intensity on diffusion-weighted magnetic resonance images is a useful finding for detecting early-stage pancreatic cancer". 国際誌

Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

Abdominal radiology (New York)　47　(2)　905-906　2022年2月

DOI： 10.1007/s00261-021-03346-8 　
Extra- or Peritumoral Hyperintensity on T2-weighted Images in Patients with Breast Cancer. 国際誌

Naoko Mori, Shunji Mugikura, Kei Takase

Radiology　302　(2)　E7-E8　2022年2月

DOI： 10.1148/radiol.2021210939 　
Longitudinal evaluation of apparent diffusion coefficient values as a predictor of Prostate Cancer Research International Active Surveillance reclassification. 国際誌

Eri Ota, Naoko Mori, Shinichi Yamashita, Shunji Mugikura, Akihiro Ito, Kei Takase

Abdominal radiology (New York)　47　(2)　814-826　2022年2月

DOI： 10.1007/s00261-021-03372-6 　

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PURPOSE: This study aimed to evaluate the effectiveness of apparent diffusion coefficient (ADC) parameters in distinguishing between Prostate Cancer Research International Active Surveillance (PRIAS) non-reclassification and reclassification groups during active surveillance (AS) of prostate cancer. METHODS: We included 55 patients who fulfilled the PRIAS criteria and underwent ≥ 2 magnetic resonance imaging (MRI) including diffusion-weighted imaging with an interval of ≤ 3 years between baseline and second MRI. A mono-exponential fitting model was used to automatically create ADC maps with minimum b-values of 0 and maximum of 2000 s/mm2. For detectable lesions on ADC maps, the lesions were manually segmented on each slice of the ADC maps. For undetectable lesions, the corresponding normal-appearing zone of the lobe on each slice of ADC maps was segmented. The ADC data for each slice were summed to obtain the 25th, 50th, and 75th percentile ADC values of the histogram at baseline and second MRI. These ADC parameters at baseline and second MRI, and the changes of ADC parameters from baseline to second MRI were compared between PRIAS non-reclassification and reclassification groups. RESULTS: The PRIAS reclassification group had significantly lower 25th, 50th, and 75th percentile ADC values at second MRI compared to the non-reclassification group. The non-reclassification group had significantly lower changes in ADC values in these percentiles compared to the reclassification group. CONCLUSION: The ADC parameters at second MRI and the changes from baseline to second MRI may be effective distinguishing factors between PRIAS non-reclassification and reclassification groups.
Application of cumulative summation (CUSUM) method and mathematical model to evaluate the learning effect in central venous catheter port implantation.

Naoko Mori, Hiroaki Shimizu, Shunji Mugikura, Kei Takase

Japanese journal of radiology　2022年1月22日

DOI： 10.1007/s11604-021-01242-1 　
Quantitative assessment of microstructural evolution of intracranial aneurysm wall by vessel wall imaging. 国際誌

Hidenori Endo, Naoko Mori, Shunji Mugikura, Kuniyasu Niizuma, Shunsuke Omodaka, Kei Takase, Teiji Tominaga

Neuroradiology　64　(7)　1343-1350　2022年1月8日

DOI： 10.1007/s00234-021-02877-7 　

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PURPOSE: This study aimed to evaluate new quantitative parameters of aneurysm wall enhancement (AWE) on magnetic resonance vessel wall imaging (VWI) in differentiating between the stable and evolving unruptured intracranial aneurysms (UIAs). METHODS: Thirty-eight consecutive patients with UIAs (27 stable and 11 evolving) underwent VWI with contrast-enhanced 3D T1 volume isotropic turbo spin echo acquisition. The voxel-based enhancement maps were created using pre- and post-contrast images. The aneurysmal lumen with signal suppression by black-blood method was segmented. Then, one voxel outer and inner layers of the lumen contour were automatically segmented. The shape features of the aneurysms and AWE of the two layers were compared between stable and evolving groups. RESULTS: The shape features, including aneurysm volume, surface, and compacity were significantly different between the stable and evolving groups (P = 0.024, 0.028, and 0.033, respectively). Stable and evolving groups also differed significantly in the AWE at the union of outer and inner layers of the aneurysm wall (P = 0.0082) but not in that of the outer or inner layer alone. Multivariate logistic regression analysis revealed significant differences in aneurysm volume, surface, and AWE at the union of outer and inner layers between the two groups (P = 0.0029, 0.0092, and 0.0033, respectively). Receiver operating characteristics curve analysis revealed that the area under the curve of the logistic regression model was 0.89. CONCLUSION: Quantitative combined analysis of aneurysm shape features and AWE of the union of outer and inner layers were effective for differentiating between stable and evolving UIAs.
Prediction of the development of delirium after transcatheter aortic valve implantation using preoperative brain perfusion SPECT. 国際誌

Masashi Takeuchi, Hideaki Suzuki, Yasuharu Matsumoto, Yoku Kikuchi, Kentaro Takanami, Toshihiro Wagatsuma, Jun Sugisawa, Satoshi Tsuchiya, Kensuke Nishimiya, Kiyotaka Hao, Shigeo Godo, Tomohiko Shindo, Takashi Shiroto, Jun Takahashi, Kiichiro Kumagai, Masahiro Kohzuki, Kei Takase, Yoshikatsu Saiki, Satoshi Yasuda, Hiroaki Shimokawa

PloS one　17　(11)　e0276447　2022年

DOI： 10.1371/journal.pone.0276447 　

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OBJECTIVES: Delirium is an important prognostic factor in postoperative patients undergoing cardiovascular surgery and intervention, including transcatheter aortic valve implantation (TAVI). However, delirium after transcatheter aortic valve implantation (DAT) is difficult to predict and its pathophysiology is still unclear. We aimed to investigate whether preoperative cerebral blood flow (CBF) is associated with DAT and, if so, whether CBF measurement is useful for predicting DAT. METHODS: We evaluated CBF in 50 consecutive patients before TAVI (84.7±4.5 yrs., 36 females) using 99mTc ethyl cysteinate dimer single-photon emission computed tomography. Preoperative CBF of the DAT group (N = 12) was compared with that of the non-DAT group (N = 38) using whole brain voxel-wise analysis with SPM12 and region of interest-based analysis with the easy-Z score imaging system. Multivariable logistic regression analysis with the presence of DAT was used to create its prediction model. RESULTS: The whole brain analysis showed that preoperative CBF in the insula was lower in the DAT than in the non-DAT group (P<0.05, family-wise error correction). Decrease extent ratio in the insula of the DAT group (17.6±11.5%) was also greater relative to that of the non-DAT group (7.0±11.3%) in the region of interest-based analysis (P = 0.007). A model that included preoperative CBF in the insula and conventional indicators (frailty index, short physical performance battery and mini-mental state examination) showed the best predictive power for DAT (AUC 0.882). CONCLUSIONS: These results suggest that preoperative CBF in the insula is associated with DAT and may be useful for its prediction.
Systemic-pulmonary collateral supply associated with clinical severity of chronic thromboembolic pulmonary hypertension: a study using intra-aortic computed tomography angiography

Wenyu Sun, Hideki Ota, Haruka Sato, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Koichiro Sugimura, Junya Tominaga, Hiroaki Shimokawa, Takuya Ueda, Kei Takase

European Radiology　32　(11)　7668-7679　2022年

DOI： 10.1007/s00330-022-08768-6 　

ISSN：0938-7994

eISSN：1432-1084
Significance of systolic-phase imaging on full-phase ECG-gated CT angiography to detect intimal tears in aortic dissection

Satoru Yanagaki, Atsuro Masuda, Hideki Ota, Masatoshi Kojima, Takashi Hattori, Wahei Mihara, Kei Takase, Takuya Ueda

Heart and Vessels　37　(11)　1947-1956　2022年

DOI： 10.1007/s00380-022-02093-0 　

ISSN：0910-8327

eISSN：1615-2573
Clinical assessment of efficacy of poly-L-lactide sternal pin on sternal stability and post-operative pain: a prospective randomized trial in cardiovascular surgery. 国際誌

Shingo Takahara, Konosuke Sasaki, Takeshi Saito, Kei Sakuma, Hidenori Fujiwara, Ichiro Yoshioka, Kiichiro Kumagai, Wenyu Sun, Kei Takase, Yoshikatsu Saiki

Journal of thoracic disease　14　(1)　76-89　2022年1月

DOI： 10.21037/jtd-21-1340 　

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BACKGROUND: Although the incident rate is low, sternal dislocation and dehiscence due to unstable sternal fixation after cardiovascular surgery could cause potentially lethal complications. Thus, to enforce the stability of closed sternum, the sternal pins have been utilized at surgeon's discretion. However, there is no randomized clinical trial to test whether these pins are effective to stabilize a sternum. Hence, this study aimed to examine the clinical efficacy of bioabsorbable poly-L-lactide (PLLA) sternal pins in reinforcing sternal stability and preventing instability of the sternum after full sternotomy. METHODS: We conducted a single institutional, prospective, randomized, single-blinded clinical study involving 100 patients who underwent an initial cardiovascular surgery via sternotomy. Patients were randomly allocated into two groups: with (group P) and without (group N) PLLA sternal pins, at 1:1 ratio from November 2013 to April 2016. Sternal deviation and stability were assessed with postoperative computed tomography (CT) at two postures to put shear stress on the sternum. Additionally, information on patient demographic indices was obtained prospectively, and patient's pain intensity was assessed with numerical rating scoring system during rehabilitation. Furthermore, propensity score matching was performed for further comparative sub-analysis. RESULTS: Ninety-one patients (43 in group P and 48 in group N) were analyzed using the intention-to-treat method. Group N had a significantly higher proportion of males (P=0.015) and ischemic disease as a primary diagnosis (P=0.040) than group P. Postoperative CT showed that the degree of sternal deviation and stability were comparable between the groups. Similarly, the numerical rating score of pain during rehabilitation showed no difference between the groups. Even after adjusting for patient characteristics using propensity score matching method, no significant differences in sternal gaps, stability, and numerical rating score of pain were observed. Of note, no material-related adverse event such as wound infection was found. CONCLUSIONS: We could not identify the efficacy of the sternal pin in enforcing sternal stability based on CT measurements with mild shear stress on sternum after cardiovascular surgery. Nevertheless, our results with no adverse events might encourage further investigations with a more specific cohort who is susceptible to infection but requires an additional sternal fixation. TRIAL REGISTRATION: This study was registered in University Hospital Medical Information Network Clinical Trial Registry (UMIN000017357).
Reversible increase in stress-associated neurobiological activity in the acute phase of Takotsubo syndrome; a brain 18F-FDG-PET study. 国際誌

Hideaki Suzuki, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa, Satoshi Yasuda

International journal of cardiology　344　31-33　2021年12月1日

DOI： 10.1016/j.ijcard.2021.09.057 　

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INTRODUCTION: Takotsubo syndrome (TTS) is triggered mostly by physical and/or emotional stress that is processed in stress-associated brain regions, including the amygdala. However, it remains unclear whether such stress-induced brain activity is associated with TTS onset. METHODS AND RESULTS: We acquired brain [18F]-2-fluoro-deoxy-d-glucose (18F-FDG) positron emission tomography in 4 TTS patients (44-82 yrs., 3 women) on days 2-4 (acute phase) and days 29-40 (recovery phase) after diagnosis of TTS was made by coronary angiography and left ventriculogram. The 18F-FDG uptake was measured globally and also in the pre-defined regions of interest of the bilateral amygdala on the common Montreal Neurological Institute space; all 18F-FDG images were normalized using automated image pre-processing. Amygdalar activity was calculated by dividing the 18F-FDG uptake of the amygdala by the global brain uptake. Left ventriculograms showed that apical ballooning was typical at diagnosis and was then relieved in the recovery phase. Amygdalar activity in the acute phase (0.872 ± 0.032) was higher than in the recovery phase (0.805 ± 0.037) (P = 0.013). CONCLUSIONS: We report here 4 cases of TTS showing higher amygdalar activity in the acute phase as compared with the recovery phase, suggesting that increased stress-induced neurobiological activity is associated with TTS onset.
Fibromuscular dysplasia with recurrence after “long-term” following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients

Shuntaro Oribe, Takafumi Toyohara, Eikan Mishima, Takehiro Suzuki, Koichi Kikuchi, Shun Watanabe, Yoshiaki Morita, Hideki Ota, Kazumasa Seiji, Mariko Miyazaki, Kei Takase, Takaaki Abe

BMC Nephrology　22　(1)　2021年12月

DOI： 10.1186/s12882-021-02342-w 　

eISSN：1471-2369
Carotid computed tomography angiography after cobalt-based alloy carotid artery stenting using ultra-high-resolution computed tomography with model-based iterative reconstruction

Shingo Kayano, Hideki Ota, Yoshimichi Sato, Toshiki Endo, Kuniyasu Niizuma, Ichiro Suzuki, Tsuyoshi Kawamura, Kei Takase

Radiology Case Reports　16　(12)　3721-3728　2021年12月

DOI： 10.1016/j.radcr.2021.09.003 　

eISSN：1930-0433
Importance of ADC parameters from histogram analysis corresponding to histological components in endometrial cancer. 国際誌

Naoko Mori, Shunji Mugikura, Kei Takase

European journal of radiology　144　110004-110004　2021年11月

DOI： 10.1016/j.ejrad.2021.110004 　
Prediction of placenta accreta spectrum using texture analysis on coronal and sagittal T2-weighted imaging. 国際誌

Hainan Ren, Naoko Mori, Shunji Mugikura, Hiroaki Shimizu, Sakiko Kageyama, Masatoshi Saito, Kei Takase

Abdominal radiology (New York)　46　(11)　5344-5352　2021年11月

DOI： 10.1007/s00261-021-03226-1 　

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PURPOSE: To separately perform visual and texture analyses of the axial, coronal, and sagittal planes of T2-weighted images and identify the optimal method for differentiating between the normal placenta and placenta accreta spectrum (PAS). METHODS: Eighty consecutive patients (normal group, n = 50; PAS group, n = 30) underwent preoperative MRI. A scoring system (0-2) was used to evaluate the degree of abnormality observed in visual analysis (bulging, abnormal vascularity, T2 dark band, placental heterogeneity). The axial, coronal, and sagittal planes were manually segmented separately to obtain texture features, and seven combinations were obtained: axial; coronal; sagittal; axial and coronal; axial and sagittal; coronal and sagittal; and axial, coronal, and sagittal. Feature selection using the least absolute shrinkage and selection operator method and model construction using a support vector machine algorithm with k-fold cross-validation were performed. AUC was used to evaluate diagnostic performance. RESULTS: The AUC of visual analysis was 0.75. The model 'coronal and sagittal' had the highest AUC (0.98) amongst the seven combinations. The fivefold cross-validation for the model 'coronal and sagittal' showed AUCs of 0.85 and 0.97 in training and validation sets, respectively. The AUC of the model 'coronal and sagittal' for all subjects was significantly higher than that of visual analysis (0.98 vs. 0.75; p < 0.0001). CONCLUSION: The model 'coronal and sagittal' can accurately differentiate between the normal placenta and PAS, with a significantly better diagnostic performance than visual analysis. Texture analysis is an optimal method for differentiating between the normal placenta and PAS.
アルドステロン産生腺腫における18-oxocortisol産生機序の解明

手塚雄太, 山崎有人, 尾股慧, 小野美澄, 森本玲, 高瀬圭, 川崎芳英, 伊藤明宏, 西川潤, 朝井典子, Gomez-Sanchez Celso E., 伊藤貞嘉, 出澤真里, 笹野公伸, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　43回　219-219　2021年10月
出版者・発行元： (NPO)日本高血圧学会
片側性原発性アルドステロン症の発症経過を捉え得た若年性高血圧症の一例

手塚雄太, 小野美澄, 山崎有人, 樋口慧, 尾股慧, 森本玲, 大田英揮, 川崎芳英, 高瀬圭, 伊藤明宏, 笹野公伸, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　43回　281-281　2021年10月
出版者・発行元： (NPO)日本高血圧学会
Indication of perfusion contrast-enhanced ultrasound for diagnosing lymph nodes.

Naoko Mori, Shunji Mugikura, Kei Takase

Japanese journal of radiology　39　(10)　1017-1018　2021年10月

DOI： 10.1007/s11604-021-01160-2 　
Utility of histogram analysis for apparent diffusion coefficient values in evaluating the pathological characteristics of endometrial cancer. 国際誌

Naoko Mori, Shunji Mugikura, Kei Takase

The British journal of radiology　20210928-20210928　2021年9月14日

DOI： 10.1259/bjr.20210928 　
Cholangiojejunostomy assisted by techniques of interventional radiology for a patient with recurrent jaundice after Kasai portoenterostomy

Ryuji Okubo, Hideyuki Sasaki, Hideki Ota, Motoshi Wada, Taichi Fukuzawa, Hironori Kudo, Ryo Ando, Yuki Endo, Masatoshi Hashimoto, Kosuke Sato, Kei Takase, Masaki Nio

Journal of Pediatric Surgery Case Reports　72　2021年9月

DOI： 10.1016/j.epsc.2021.101961 　

eISSN：2213-5766
Pancreatic foregut cystic malformation with a bifid pancreatic tail

Yuki Endo, Motoshi Wada, Hideyuki Sasaki, Taichi Fukuzawa, Hironori Kudo, Ryo Ando, Satoshi Yamaki, Ryuji Okubo, Masatoshi Hashimoto, Yudai Nakajima, Kosuke Sato, Hidekazu Aoki, Hideki Ota, Kei Takase, Masaki Nio

Journal of Pediatric Surgery Case Reports　72　101963-101963　2021年9月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.epsc.2021.101963 　

ISSN：2213-5766
Experimental Analysis of Pressure and Flow Alterations During and After Insertion of a Multilayer Flow Modulator into an AAA Model with Incorporated Branch. 国際誌

Simon Tupin, Kei Takase, Makoto Ohta

Cardiovascular and interventional radiology　44　(8)　1251-1259　2021年8月

DOI： 10.1007/s00270-021-02835-z 　

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PURPOSE: The multilayer flow modulator (MFM) device has been used for the treatment of abdominal aortic aneurysm (AAA) for over a decade. Although several clinical studies have been published, criticism and concern over the device efficacy remain, as no quantitative analysis that describes its mechanism has been performed yet. The aim of this study was to experimentally evaluate the effect of MFM device deployment on aneurysmal pressure and branch perfusion. MATERIALS AND METHODS: An experimental flow and pressure monitoring system was developed to analyze the MFM deployment procedure performed by a qualified radiologist in AAA geometries with and without side branch. Particle image velocimetry experiments were then conducted on models with and without MFM device to evaluate and compare flow patterns and local flow velocity and vorticity in the aneurysm. RESULTS: The experiments revealed no significant change in pressure and flow rate during and after deployment of the MFM device. The flow rate of the incorporated branch was fully preserved. On both models, the aneurysmal flow velocity was significantly reduced. In addition, the device modified local flow patterns, reducing vorticity and better feeding the incorporated branch. CONCLUSION: This experimental study provides the basis for a better understanding of the mechanism of the MFM device, which allows intra-aneurysmal flow to decrease while preserving incorporated branch flow and reducing the risk of type II endoleak. The experimental system developed for this study was effective in simulating an endovascular procedure and studying the safety and effectiveness of endovascular devices.
Mathematical model for histogram analysis of dynamic contrast-enhanced MRI: A method to evaluate the drug treatment response in rheumatoid arthritis

Yu Mori, Naoko Mori, Takuya Izumiyama, Asami Inoue, Kei Takase, Toshimi Aizawa

European Journal of Radiology　141　109831-109831　2021年8月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.ejrad.2021.109831 　

ISSN：0720-048X
Efficacy of cell proliferation imaging with 4DST PET/CT for predicting the prognosis of patients with esophageal cancer: a comparison study with FDG PET/CT

Masatoshi Hotta, Ryogo Minamimoto, Jun Toyohara, Kyoko Nohara, Kazuhiko Nakajima, Kei Takase, Kazuhiko Yamada

European Journal of Nuclear Medicine and Molecular Imaging　48　(8)　2615-2623　2021年7月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s00259-020-05179-x 　

ISSN：1619-7070

eISSN：1619-7089
Assessment of the sequential time–signal enhancement curve of dynamic contrast-enhanced MRI might be effective in diagnosing growth hormone-producing pituitary adenomas

Naoko Mori, Shunji Mugikura, Kei Takase

Japanese Journal of Radiology　2021年6月4日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s11604-021-01146-0 　

ISSN：1867-1071

eISSN：1867-108X
葛西手術後長期経過後の肝門部再閉塞に対してIVRが有用であった1例

田中拡, 大田英揮, 佐々木英之, 佐野信行, 北見昌広, 齋藤美穂子, 和田基, 福澤太一, 中村恵美, 工藤博典, 安藤亮, 山木聡史, 大久保龍二, 高瀬圭, 仁尾正記

日本小児外科学会雑誌　57　(4)　791-791　2021年6月
出版者・発行元： (一社)日本小児外科学会
ISSN：0288-609X

eISSN：2187-4247
Ultrashort echo time time-spatial labeling inversion pulse magnetic resonance angiography with denoising deep learning reconstruction for the assessment of abdominal visceral arteries

Ryuichi Mori, Yoshimori Kassai, Atsuro Masuda, Yoshiaki Morita, Tomoyoshi Kimura, Tatsuo Nagasaka, Takashi Nishina, Sho Tanaka, Mitsue Miyazaki, Kei Takase, Hideki Ota

Journal of Magnetic Resonance Imaging　53　(6)　1926-1937　2021年6月

DOI： 10.1002/jmri.27481 　

ISSN：1053-1807

eISSN：1522-2586
【皮膚悪性腫瘍(第2版)上-基礎と臨床の最新研究動向-】メラノーマメラノーマの検査・診断画像診断 CT、MRI

木下知, 森下陽平, 高瀬圭

日本臨床　79　(増刊2 皮膚悪性腫瘍(上))　225-228　2021年5月
出版者・発行元： (株)日本臨床社
ISSN：0047-1852
Discriminating low-grade ductal carcinoma in situ (DCIS) from non-low-grade DCIS or DCIS upgraded to invasive carcinoma: effective texture features on ultrafast dynamic contrast-enhanced magnetic resonance imaging

Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yo Oguma, Minami Hirasawa, Satoko Sato, Kei Takase

Breast Cancer　2021年4月26日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s12282-021-01257-6 　

ISSN：1340-6868

eISSN：1880-4233
Beneficial effects of exercise training on physical performance in patients with vasospastic angina. 国際誌

Jun Sugisawa, Yasuharu Matsumoto, Masashi Takeuchi, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Ohura, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

International journal of cardiology　328　14-21　2021年4月1日

DOI： 10.1016/j.ijcard.2020.12.003 　

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AIMS: In vasospastic angina (VSA), coronary vasomotion abnormalities could develop not only in epicardial coronary arteries but also in coronary microvessels, where calcium channel blockers (CCBs) have limited efficacy. However, efficacy of exercise training for VSA remains to be elucidated. We thus aimed to examine whether vasodilator capacity of coronary microvessels is impaired in VSA patients, and if so, whether exercise exerts beneficial effects on the top of CCBs. METHODS: We performed 2 clinical protocols. In the protocol 1, we measured myocardial blood flow (MBF) using adenosine-stress dynamic computed tomography perfusion (CTP) in 38 consecutive VSA patients and 17 non-VSA controls. In the protocol 2, we conducted randomized controlled trial, where 20 VSA patients were randomly assigned to either 3-month exercise training group (Exercise group) or Non-Exercise group (n= 10 each). RESULTS: In the protocol 1, MBF on CTP was significantly decreased in the VSA group compared with the Non-VSA group (138 ± 6 vs 166 ± 10 ml/100 g/min, P = 0.02). In the protocol 2, exercise capacity was significantly increased in the Exercise group than in the Non-Exercise group (11.5 ± 0.5 to 15.4 ± 1.8 vs 12.6 ± 0.7 to 14.0 ± 0.8 ml/min/kg, P < 0.01). MBF was also significantly improved after 3 months only in the Exercise group (Exercise group, 145 ± 12 to 172 ± 8 ml/100 g/min, P < 0.04; Non-Exercise group, 143 ± 14 to 167 ± 8 ml/100 g/min, P = 0.11), although there were no significant between-group differences. CONCLUSIONS: These results provide the first evidence that, in VSA patients, exercise training on the top of CCBs treatment may be useful to improve physical performance, although its effect on MBF may be minimal.
Value of ultrafast and standard dynamic contrast-enhanced magnetic resonance imaging in the evaluation of the presence and extension of residual disease after neoadjuvant chemotherapy in breast cancer

Erina Kato, Naoko Mori, Shunji Mugikura, Satoko Sato, Takanori Ishida, Kei Takase

Japanese Journal of Radiology　2021年3月20日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s11604-021-01110-y 　

ISSN：1867-1071

eISSN：1867-108X
Usefulness of Native T1 Mapping for Prediction of Chemotherapeutics-related Cardiac Dysfunction in Breast Cancer Patients(和訳中)

照井洋輔, 杉村宏一郎, 大田英揮, 多田寛, 勝田祐子, 佐藤遥, 後岡広太郎, 建部俊介, 宮田敏, 坂田泰彦, 石田孝宜, 高瀬圭, 安田聡

日本循環器学会学術集会抄録集　85回　OJ29-5　2021年3月
出版者・発行元： (一社)日本循環器学会
Correction to: Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. 国際誌

Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase

European radiology　31　(3)　1780-1781　2021年3月

DOI： 10.1007/s00330-020-07144-6 　
The Potential of Computed Tomography Volumetry for the Surgical Treatment in Bilateral Macronodular Adrenal Hyperplasia: A Case Report.

Hiromu Matsunaga, Yuta Tezuka, Tomo Kinoshita, Hiroko Ogata, Yuto Yamazaki, Beata Shiratori, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Akihiro Ito, Hironobu Sasano, Hideo Harigae, Fumitoshi Satoh

The Tohoku journal of experimental medicine　253　(2)　143-150　2021年2月

DOI： 10.1620/tjem.253.143 　

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Although adrenal resection is a major option to control hypercortisolemia in patients with bilateral macronodular adrenal hyperplasia, a predictive method for postoperative cortisol production has not been established. A 53-year-old man with ulcerative colitis was referred to our hospital for bilateral multiple adrenal nodules and hypertension. Physical and endocrinological examination revealed inappropriate cortisol production and suppressed secretion of adrenocorticotropic hormone with no typical signs of Cushing's syndrome. Imaging analysis revealed bilateral adrenal nodular enlargement, the nodules of which had the radiological features of adrenocortical adenomas without inter-nodular heterogeneity. In addition, computed tomography volumetry demonstrated that the left adrenal gland (70 mL) accounts for three quarters of the total adrenal volume (93 mL). The patient was diagnosed as subclinical Cushing's syndrome due to bilateral macronodular adrenal hyperplasia, and subsequently underwent a left laparoscopic adrenalectomy with the estimation of 75% decrease in the cortisol level based on the adrenal volume. The surgical treatment ultimately resulted in control of the cortisol level within the normal range, which was compatible to our preoperative prediction. However, regardless of the sufficient cortisol level, ulcerative colitis was exacerbated after the surgery, which needed a systemic therapy for remission. This case indicates successful surgical control of hypercortisolemia based on computed tomography volumetry in bilateral macronodular adrenal hyperplasia, as well as the perioperative exacerbation risk for inflammatory diseases in Cushing's syndrome. We report the potential utility of computed tomography volumetry as a quantitative method with retrospective evaluation of our historical cases.
Treatment of Refractory Hypertension with Timely Angioplasty in Total Renal Artery Occlusion with Atrophic Kidney.

Yuri Sasaki, Eikan Mishima, Koichi Kikuchi, Takafumi Toyohara, Takehiro Suzuki, Hideki Ota, Kazumasa Seiji, Mariko Miyazaki, Hideo Harigae, Sadayoshi Ito, Kei Takase, Takaaki Abe

Internal medicine (Tokyo, Japan)　60　(2)　287-292　2021年1月15日

DOI： 10.2169/internalmedicine.5290-20 　

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Angioplasty for cases of chronic total occlusion of renal artery with/without atrophic kidney is generally not recommended. We herein report a 57-year-old man who presented with renin-mediated refractory hypertension caused by occlusion of a unilateral renal artery leading to kidney atrophy (length: 69 mm). Angioplasty favorably achieved blood pressure control with normalized renin secretion and enlargement of the atrophic kidney to 85 mm. Timely angioplasty can be beneficial in select patients, even with an atrophic kidney and total occlusion, especially in cases with deterioration of hypertension within six months and the presence of collateral perfusion to the affected kidney.
Abnormal Findings on "T1WI or DWI or MRCP:" An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group. 国際誌

Hainan Ren, Naoko Mori, Minami Hirasawa, Shin Hamada, Shunji Mugikura, Atsushi Masamune, Kei Takase

Journal of clinical imaging science　11　54-54　2021年

DOI： 10.25259/JCIS_158_2021 　

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Objectives: The objectives of the study was to evaluate the diagnostic performance of findings on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and magnetic resonance cholangiopancreatography (MRCP) separately and to identify an optimal Boolean interpretation model for discriminating patients with small pancreatic ductal adenocarcinoma (PDAC) from control groups in clinical practice. Material and Methods: We retrospectively enrolled 30 patients with surgery confirmed small PDAC (≤20 mm) and 302 patients without pancreatic abnormality between April 2008 and February 2020. The presence of masses was evaluated by T1WI, T2WI, and DWI. Abnormality of the main pancreatic duct (MPD) was evaluated by T2WI and MRCP. Multivariate logistic regression analysis was performed to select significant sequences for discriminating the small PDAC and control groups. Boolean operators "OR" or "AND" were used to construct sequence combinations. Diagnostic performances of these sequences and combinations were evaluated by X 2 tests. Results: The sensitivity of T2WI was lowest (20%) for detecting masses. For evaluating MPD abnormality, sensitivity was higher for MRCP than for T2WI (86.7% vs. 53.3%). Multivariate logistic regression analysis showed that T1WI and DWI for detecting the presence of masses and MRCP for evaluating MPD abnormality were significantly associated with differentiation between the two groups (P = 0.0002, P = 0.0484, and P < 0.0001, respectively). Seven combinations were constructed with T1WI, DWI, and MRCP. The combination of findings on "T1WI or DWI or MRCP" achieved the highest sensitivity of 96.7% and negative predictive value of 99.6%. Conclusion: The combination of findings on "T1WI or DWI or MRCP" might be an optimal interpretation model for discriminating small PDAC from control groups in clinical practice.
Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. 国際誌

Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase

European radiology　31　(1)　55-64　2021年1月

DOI： 10.1007/s00330-020-07047-6 　

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OBJECTIVES: The purpose of our study was to perform Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma, and to evaluate the relationship between histological grade and the ratios of the different clusters in each patient. METHODS: This retrospective study enrolled 122 patients (training: n = 63; and validation: n = 59) imaged between May 2015 and February 2020. In the training cohort, manual segmentation was performed on the ADC maps to obtain the ADC data of each patient, and these ADC data were summated to obtain the "All-patient" ADC data. Cluster analysis (three clusters) was performed on this All-patient ADC data, and the ADC ranges of each cluster were defined as follows: cluster 1, 490-699 × 10-6 mm2/s; cluster 2, 700-932 × 10-6 mm2/s; and cluster 3, over 933 × 10-6 mm2/s. In the training and validation cohorts, the ADC data of each patient was classified into three clusters according to these ADC ranges. The cluster ratios of each patient were calculated and compared with histological grade. RESULTS: In the training cohort, a significant positive correlation was found between the cluster 1 ratio and histological grade (ρ = 0.34, p = 0.0059). The cluster 1 ratios of high-grade lesions (grade 3) were significantly higher than those of low-grade lesions (grades 1 and 2) (p = 0.0084). A similar significant positive correlation was found between the cluster 1 ratio and histological grade in the validation cohort (ρ = 0.44, p = 0.0006). CONCLUSIONS: The cluster 1 ratio containing voxels with low ADC was significantly correlated with the histological grade of endometrioid carcinoma. KEY POINTS: • We performed Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma. • The cluster 1 ratio, which included low ADC values, was significantly positive correlated with histological grade in the training and validation cohorts. • The GMM-based cluster analysis of voxel-based ADC data was effective for grading endometrioid carcinoma.
Aldosterone-induced cardiac damage in primary aldosteronism depends on its subtypes. 国際誌

Satoshi Higuchi, Hideki Ota, Yuta Tezuka, Kazumasa Seiji, Hidenobu Takagi, Jongmin Lee, Yi-Wei Lee, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, Kei Takase

Endocrine connections　10　(1)　29-36　2021年1月

DOI： 10.1530/EC-20-0504 　

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Objectives: This study compared cardiac function, morphology, and tissue characteristics between two common subtypes of primary aldosteronism (PA) using a 3T MR scanner. Design: A retrospective, single-center, observational study. Methods: We retrospectively reviewed 143 consecutive patients with PA, who underwent both adrenal venous sampling and cardiac magnetic resonance. We acquired cine, late gadolinium enhancement, and pre- and postcontrast myocardial T1-mapping images. Results: PA was diagnosed as unilateral aldosterone-producing adenoma (APA) in 70 patients and bilateral hyperaldosteronism (BHA) in 73. The APA group showed significantly higher plasma aldosterone concentration (PAC) and aldosterone to renin rate (ARR) than the BHA group. After controlling for age, sex, antihypertensive drugs, systolic and diastolic blood pressure, and disease duration, the parameters independently associated with APA were: left ventricular end-diastolic volume index (EDVI: adjusted odds ratio (aOR) = 1.06 (95% CI: 1.030-1.096), P < 0.01), end-systolic volume index (ESVI: 1.06 (1.017-1.113), P < 0.01), stroke index (SI: 1.07 (1.020-1.121), P < 0.01), cardiac index (CI: 1.001 (1.000-1.001), P < 0.01), and native T1 (1.01 (1.000-1.019), P = 0.038). Weak positive correlations were found between PAC and EDVI (R = 0.28, P < 0.01), ESVI (0.26, P < 0.01), and SI (0.18, P = 0.03); and between ARR and EDVI (0.25, P < 0.01), ESVI (0.24, P < 0.01), and native T1 (0.17, P = 0.047). Conclusions: APA is associated with greater LV volumetric parameters and higher native T1 values, suggesting a higher risk of volume overload and myocardial damage.
Embolization of a paraumbilical shunt by the transparaumbilical venous approach and one-sheath inverse method: A case report

Hiroki Kamada, Hideki Ota, Kazumasa Seiji, Kei Takase

Radiology Case Reports　15　(11)　2125-2128　2020年11月

DOI： 10.1016/j.radcr.2020.08.030 　

eISSN：1930-0433
Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney. 国際誌

Tomoyuki Iwasaki, Eikan Mishima, Takehiro Suzuki, Koichi Kikuchi, Takafumi Toyohara, Kazumasa Seiji, Kei Takase, Mariko Miyazaki, Hideo Harigae, Sadayoshi Ito, Takaaki Abe

Hypertension research : official journal of the Japanese Society of Hypertension　43　(11)　1214-1221　2020年11月

DOI： 10.1038/s41440-020-0473-6 　

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Renal artery stenosis causes kidney ischemia, reducing the size of the affected kidney, which eventually results in atrophy. Although renal atrophy is considered irreversible, resolution of the ischemia occasionally restores kidney size when the cause is renal artery stenosis. Angioplasty is effective in patients with nonatherosclerotic renovascular diseases (non-ARVDs). Nevertheless, renal enlargement after angioplasty has not been fully examined. We conducted a retrospective study to examine this phenomenon in non-ARVD patients. Ten patients with a <100-mm pole-to-pole length of the poststenotic kidney were treated with angioplasty. Data were collected up to 12 months after angioplasty. The mean age was 28 years; the estimated glomerular filtration rate was 92 ± 7 mL/min/1.73 m2 (mean ± SEM); blood pressure was 150/99 mmHg; 80% were women; and fibromuscular dysplasia was present in 90% of the patients. All patients had hypertension. The lengths of the poststenotic and contralateral kidney before angioplasty were 91 ± 1 and 111 ± 3 mm, respectively. After angioplasty, the length of the poststenotic kidney gradually increased during the 3 months after treatment (+5.4 mm) and that of the contralateral kidney decreased over the same time course (-3.7 mm). Enlargement was also found in the moderate atrophy subgroup (length < 92 mm), and it was greater in the <30 years old group. In a noteworthy case, renal size in the poststenotic kidney recovered from 87 to 102 mm after angioplasty. Our findings demonstrated that reduced renal size can be reversed after optimal angioplasty in non-ARVD patients, especially young patients, suggesting reversibility of the ischemic kidney.
生体肝移植後の晩期胆道閉塞に対し超音波ガイド下に経皮的胆道空腸瘻形成を行った1例

影山咲子, 大田英揮, 鎌田裕基, 高瀬圭, 宮城重人

超音波医学　47　(Suppl.)　S286-S286　2020年11月
出版者・発行元： (公社)日本超音波医学会
ISSN：1346-1176

eISSN：1881-9311
Prognostic value of FDG-PET radiomics with machine learning in pancreatic cancer. 国際誌

Yoshitaka Toyama, Masatoshi Hotta, Fuyuhiko Motoi, Kentaro Takanami, Ryogo Minamimoto, Kei Takase

Scientific reports　10　(1)　17024-17024　2020年10月12日

DOI： 10.1038/s41598-020-73237-3 　

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Patients with pancreatic cancer have a poor prognosis, therefore identifying particular tumor characteristics associated with prognosis is important. This study aims to investigate the utility of radiomics with machine learning using 18F-fluorodeoxyglucose (FDG)-PET in patients with pancreatic cancer. We enrolled 161 patients with pancreatic cancer underwent pretreatment FDG-PET/CT. The area of the primary tumor was semi-automatically contoured with a threshold of 40% of the maximum standardized uptake value, and 42 PET features were extracted. To identify relevant PET parameters for predicting 1-year survival, Gini index was measured using random forest (RF) classifier. Twenty-three patients were censored within 1 year of follow-up, and the remaining 138 patients were used for the analysis. Among the PET parameters, 10 features showed statistical significance for predicting overall survival. Multivariate analysis using Cox HR regression revealed gray-level zone length matrix (GLZLM) gray-level non-uniformity (GLNU) as the only PET parameter showing statistical significance. In RF model, GLZLM GLNU was the most relevant factor for predicting 1-year survival, followed by total lesion glycolysis (TLG). The combination of GLZLM GLNU and TLG stratified patients into three groups according to risk of poor prognosis. Radiomics with machine learning using FDG-PET in patients with pancreatic cancer provided useful prognostic information.
Effective apparent diffusion coefficient parameters for differentiation between mass-forming autoimmune pancreatitis and pancreatic ductal adenocarcinoma

Hainan Ren, Naoko Mori, Shin Hamada, Chiaki Takasawa, Shunji Mugikura, Atsushi Masamune, Kei Takase

Abdominal Radiology　2020年10月10日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s00261-020-02795-x 　

ISSN：2366-004X

eISSN：2366-0058
Dose-dependent Radiation-induced Myocardial Damage in Esophageal Cancer Treated with Chemoradiotherapy: A Prospective Cardiac Magnetic Resonance Imaging Study 査読有り

Rei Umezawa, Noriyuki Kadoya, Hideki Ota, Yujiro Nakajima, Masahide Saito, Hidenobu Takagi, Kentaro Takanami, Noriyoshi Takahashi, Yojiro Ishikawa, Takaya Yamamoto, Haruo Matsushita, Ken Takeda, Kei Takase, Keiichi Jingu

Advances in Radiation Oncology　5　(6)　1170-1178　2020年8月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.adro.2020.07.012 　

ISSN：2452-1094
Detection of the intimal tear in aortic dissection and ulcer-like projection in intramural hematoma: usefulness of full-phase retrospective ECG-gated CT angiography

Satoru Yanagaki, Takuya Ueda, Atsuro Masuda, Hideki Ota, Yuta Onaka, Masatoshi Kojima, Takashi Hattori, Wahei Mihara, Kei Takase

Japanese Journal of Radiology　2020年7月24日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s11604-020-01008-1 　

ISSN：1867-1071

eISSN：1867-108X
Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis. 国際誌査読有り

Michiko Kano, Cecilia Grinsvall, Qian Ran, Patrick Dupont, Joe Morishita, Tomohiko Muratsubaki, Shunji Mugikura, Huynh Giao Ly, Hans Törnblom, Maria Ljungberg, Kei Takase, Magnus Simrén, Lukas Van Oudenhove, Shin Fukudo

Scientific reports　10　(1)　11015-11015　2020年7月3日

DOI： 10.1038/s41598-020-67048-9 　

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Irritable bowel syndrome (IBS) is a functional disorder of brain-gut interactions. Differential brain responses to rectal distention between IBS and healthy controls (HCs) have been demonstrated, particularly in the pain matrix and the default mode network. This study aims to compare resting-state functional properties of these networks between IBS patients and HCs using graph analysis in two independent cohorts. We used a weighted graph analysis of the adjacency matrix based on partial correlations between time series in the different regions in each subject to determine subject specific graph measures. These graph measures were normalized by values obtained in equivalent random networks. We did not find any significant differences between IBS patients and controls in global normalized graph measures, hubs, or modularity structure of the pain matrix and the DMN in any of our two independent cohorts. Furthermore, we did not find consistent associations between these global network measures and IBS symptom severity or GI-specific anxiety but we found a significant difference in the relationship between measures of psychological distress (anxiety and/or depressive symptoms) and normalized characteristic path length. The responses of these networks to visceral stimulation rather than their organisation at rest may be primarily disturbed in IBS.
乳癌患者における化学療法による心毒性が原因の局所左室変形に関する経時的変化(Longitudinal Change of Regional Left Ventricular Deformation by Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

藤原淳子, 後岡広太郎, 杉村宏一郎, 照井洋輔, 佐藤遥, 多田寛, 大田英揮, 船水康陽, 三木俊, 西條芳文, 高瀬圭, 石田孝宜, 下川宏明

日本循環器学会学術集会抄録集　84回　OJ12-6　2020年7月
出版者・発行元： (一社)日本循環器学会
乳癌患者における化学療法による心毒性が原因の局所左室変形に関する経時的変化(Longitudinal Change of Regional Left Ventricular Deformation by Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

藤原淳子, 後岡広太郎, 杉村宏一郎, 照井洋輔, 佐藤遥, 多田寛, 大田英揮, 船水康陽, 三木俊, 西條芳文, 高瀬圭, 石田孝宜, 下川宏明

日本循環器学会学術集会抄録集　84回　OJ12-6　2020年7月
出版者・発行元： (一社)日本循環器学会
18F-FDG PET/CT Imaging of Vasculitis Complicated With Relapsing Polychondritis. 国際誌

Hiroki Kamada, Kentaro Takanami, Yoshitaka Toyama, Mioko Saito, Kei Takase

Clinical nuclear medicine　45　(7)　e327-e328　2020年7月

DOI： 10.1097/RLU.0000000000003060 　

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We present a case of a 38-year-old woman who complained with cough, fever, and back pain with a weight loss. F-FDG PET/CT to search fever origin revealed uptake in the tracheobronchial and the left auricular cartilage and wall of the thoracic aorta. She underwent biopsy of the left auricle and was diagnosed with relapsing polychondritis (RP) complicating vasculitis. After steroid therapy, FDG PET/CT demonstrated regression of inflammation, showing decreases in the uptakes. Vasculitis should be considered in case of RP with systemic manifestations. Our case demonstrated the utility of FDG PET/CT in evaluation of RP lesions including aortitis.
Thrombosis of a basilar perforator aneurysm associated with pontine infarction in a patient with systemic lupus erythematosus

Takaki Murata, Shuko Nomura, Eiko Yamamori, Shoki Takahashi, Kei Takase

Radiology Case Reports　15　(6)　757-760　2020年6月1日
出版者・発行元： Elsevier Inc
DOI： 10.1016/j.radcr.2020.03.009 　

ISSN：1930-0433
Clinical implication of myocardial FDG uptake pattern in oncologic PET: retrospective comparison study with stress myocardial perfusion imaging as the reference standard

Kentaro Takanami, Mioko Saito, Yasuharu Matsumoto, Koichiro Sugimura, Kei Takase

Annals of Nuclear Medicine　34　(4)　233-243　2020年4月

DOI： 10.1007/s12149-020-01437-y 　

ISSN：0914-7187

eISSN：1864-6433
【腎・泌尿器の画像診断update】原発性アルドステロン症の診断・治療

清治和将, 大田英揮, 手塚雄太, 尾股慧, 小野美澄, 森本玲, 佐藤文俊, 高瀬圭

画像診断　40　(6)　589-605　2020年4月
出版者・発行元： (株)学研メディカル秀潤社
ISSN：0285-0524

eISSN：2432-1281
Turbo Spin-echo Diffusion-weighted Imaging Compared with Single-shot Echo-planar Diffusion-weighted Imaging: Image Quality and Diagnostic Performance When Differentiating between Ductal Carcinoma in situ and Invasive Ductal Carcinoma. 査読有り

Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yui Maekawa, Tatsuo Nagasaka, Kei Takase

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　20　(1)　60-68　2020年3月6日

DOI： 10.2463/mrms.mp.2019-0195 　

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PURPOSE: To compare the image quality between turbo spin-echo (TSE)-diffusion weighted imaging (DWI) and single-shot echo-planar imaging (EPI)-DWI, and to verify the diagnostic performance of the apparent diffusion coefficient (ADC) parameters of the two techniques by using histogram analysis in terms of differentiation between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) lesions. METHODS: Ninety-four women with 94 lesions diagnosed as breast cancer by surgery underwent IRB-approved preoperative magnetic resonance imaging, including TSE and EPI-DWI with b-values of 50 and 850 s/mm2. Twenty lesions were identified as DCIS and 74 as IDC. Image quality [signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and geometric distortion] was evaluated quantitatively and compared between the TSE and EPI-DWI. A histogram analysis of the entire tumor voxel-based ADC data was performed, and the 10th, 25th, 50th, 75th, and 90th percentile values of each technique were compared between DCIS and IDC lesions. RESULTS: The SNR and CNR of TSE-DWI were significantly higher than those of EPI-DWI (P < 0.0001 and < 0.0001). The geometric distortion of TSE-DWI was significantly lower than that of EPI-DWI (P < 0.0001). In TSE-DWI, the 10th, 25th, 50th, and 75th percentile values were significantly different between the DCIS and IDC lesions (P = 0.0010, 0.0004, 0.0008, and 0.0044, respectively). In EPI-DWI, the 50th and 75th percentile values were significantly different between the two groups (P = 0.0009 and 0.0093). There was no significant difference in the area under the curve of the receiver operating characteristic analysis of the 10th, 25th, 50th, and 75th percentile values of TSE-DWI, and the 50th and 75th percentile values of EPI-DWI (P = 0.29). CONCLUSION: The image quality of TSE-DWI was better than that of EPI-DWI. DCIS lesions were distinguished from IDC lesions with a wider range of percentile values in TSE-DWI than in EPI-DWI, although diagnostic performance was not significantly different between the techniques.
Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm 査読有り

Shunji Mugikura, Naoko Mori, Hirokazu Kikuchi, Etsuro Mori, Shoki Takahashi, Kei Takase

Annals of Nuclear Medicine　34　(3)　220-227　2020年3月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s12149-020-01436-z 　

ISSN：0914-7187

eISSN：1864-6433

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<title>Abstract</title><sec> <title>Objective</title> Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia. </sec><sec> <title>Methods</title> Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on ¹²³I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. The Severity (average <italic>Z</italic> score of the voxels with a <italic>Z</italic> score that exceeds a threshold value of 2) was calculated. The cerebral lobes with rCBF exhibiting Severity > 2 in all patients were identified. In these lobes, we then examined whether there was a gyrus exhibiting Severity that was negatively related to memory quotients (MQs). </sec><sec> <title>Results</title> In the right subcallosal gyrus, there was a significant negative correlation between Severity and visual MQ (<italic>ρ</italic>= − 0.884, <italic>p</italic> = 0.0007) or general MQ (<italic>ρ</italic> =− 0.853, <italic>p</italic> = 0.0017). In the right anterior cingulate gyrus, there was a significant negative correlation between Severity and verbal MQ (<italic>ρ</italic> = − 0.769, <italic>p</italic> = 0.0092). In the right rectal gyrus, there was a significant negative correlation between Severity and general MQ (<italic>ρ</italic> = − 0.811, <italic>p</italic> = 0.0044). No significant correlations were found between Severity in other brain regions and verbal, visual, or general MQ. </sec><sec> <title>Conclusions</title> The decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia. </sec>
Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm.

Shunji Mugikura, Naoko Mori, Hirokazu Kikuchi, Etsuro Mori, Shoki Takahashi, Kei Takase

Annals of nuclear medicine　34　(3)　220-227　2020年3月

DOI： 10.1007/s12149-020-01436-z 　

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OBJECTIVE: Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia. METHODS: Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on 123I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. The Severity (average Z score of the voxels with a Z score that exceeds a threshold value of 2) was calculated. The cerebral lobes with rCBF exhibiting Severity > 2 in all patients were identified. In these lobes, we then examined whether there was a gyrus exhibiting Severity that was negatively related to memory quotients (MQs). RESULTS: In the right subcallosal gyrus, there was a significant negative correlation between Severity and visual MQ (ρ= - 0.884, p = 0.0007) or general MQ (ρ =- 0.853, p = 0.0017). In the right anterior cingulate gyrus, there was a significant negative correlation between Severity and verbal MQ (ρ = - 0.769, p = 0.0092). In the right rectal gyrus, there was a significant negative correlation between Severity and general MQ (ρ = - 0.811, p = 0.0044). No significant correlations were found between Severity in other brain regions and verbal, visual, or general MQ. CONCLUSIONS: The decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia.
4D-flow MRI assessment of blood flow before and after endovascular intervention in a patient with pulmonary hypertension due to isolated pulmonary artery involvement in large vessel vasculitis. 国際誌

Hiroki Kamada, Hideki Ota, Tatsuo Aoki, Koichiro Sugimura, Nobuhiro Yaoita, Hiroaki Shimokawa, Kei Takase

Radiology case reports　15　(3)　190-194　2020年3月

DOI： 10.1016/j.radcr.2019.11.019 　

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A 43-year-old woman presented with dyspnea during exertion and lower leg edema. Contrast-enhanced computed tomography images demonstrated extensive proximal narrowing in the right main pulmonary artery with thickening and enhancement. Right heart catheterization revealed the presence of precapillary pulmonary hypertension with a mean pulmonary arterial pressure of 45 mm Hg. The patient was diagnosed with large-vessel vasculitis with isolated pulmonary artery involvement. Takayasu's arteritis was suspected, but histological examination was not performed. Several sessions of pulmonary arterial intervention were stratified for the right main pulmonary artery. After treatment, mean pulmonary arterial pressure had decreased to 22 mm Hg with improvement in symptoms. Thoracic 4D-flow magnetic resonance imaging was performed before and after intervention to evaluate the volume flow rates of pulmonary arteries. The rates increased at the inlet of the right pulmonary artery (before: 23 mL/s vs after: 47.5 mL/s) and the main pulmonary artery (before: 71.2 mL/s vs after: 82.5 mL/s), and decreased at the inlet of the left pulmonary artery (before: 46.2 mL/s vs after: 31.7 mL/s). The split ratio of volume flow rate between the right and left pulmonary arteries improved after treatment (before. right:left = 33.1:66.9; after, right:left = 60.0:40.0), approaching normal values. This report quantitatively describes perioperative hemodynamic changes in a patient with pulmonary hypertension using 4D-flow magnetic resonance imaging. Stent placement for stenosis in the right pulmonary artery resulted in an increase in overall pulmonary blood flow and also improved blood flow balance between the right and the left pulmonary arteries.
縦隔に発生したFollicular dendritic cell sarcomaの1例

竹下翔, 佐藤嘉尚, 冨永循哉, 高瀬圭, 井上千裕, 齊藤涼子

Japanese Journal of Radiology　38　(Suppl.)　6-6　2020年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
中期経過観察された食道癌化学放射線療法後における心事故と心臓MRI所見の関連性

梅澤玲, 角谷倫之, 松下晴雄, 山本貴也, 石川陽二郎, 片桐佑, 武田一也, 福井勝哉, 田坂俊, 鈴木友, 川端広聖, 岸田桂太, 寺村聡司, 尾股聡, 伊藤謙吾, 高山佳樹, 千葉貴仁, 神宮啓一, 大田英揮, 高瀬圭

Japanese Journal of Radiology　38　(Suppl.)　9-9　2020年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
Three cases of pulmonary tumor thrombotic microangiopathy (PTTM): Challenge in antemortem diagnosis using lung perfusion blood volume images by dual-energy computed tomography. 国際誌

Hiroki Kamada, Hideki Ota, Yosuke Terui, Koichiro Sugimura, Shigefumi Fukui, Hiroaki Shimokawa, Kei Takase

European journal of radiology open　7　100212-100212　2020年

DOI： 10.1016/j.ejro.2020.01.001 　

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Pulmonary tumor thrombotic microangiopathy (PTTM) is a specific type of tumor embolism in the small and medium pulmonary arteries, leading to rapid progressive pulmonary hypertension. Antemortem diagnosis of PTTM is extremely difficult. We encountered three patients who were histopathologically or clinically diagnosed with PTTM. In all cases, lung perfused blood volume (PBV) images on dual-energy computed tomography (CT) demonstrated multiple subpleural wedge-shaped defects with no evidence of pulmonary embolism on CT pulmonary angiography. The lung PBV images demonstrated small pulmonary arterial obstruction reflecting the pathology of PTTM. Therefore, lung PBV imaging would be useful for antemortem diagnosis of PTTM.
最新半導体PET/CTにおける上腹部病変への呼吸同期の有用性

外山由貴, 高浪健太郎, 太田瑛梨, 加賀谷由里子, 前川由依, 齊藤美穂子, 高瀬圭

核医学　57　(1)　5-5　2020年
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
後腹膜腫瘍切除後椎骨動脈瘤破裂による気道閉塞から心肺停止をきたした神経線維腫症I型の1救命例

三浦孝之, 水間正道, 元井冬彦, 内藤剛, 亀井尚, 高瀬圭, 海野倫明

Japanese Journal of Acute Care Surgery　9　(2)　254-257　2020年1月
出版者・発行元：日本Acute Care Surgery学会
eISSN：2436-102X
Perioperative Hemodynamic Changes in the Thoracic Aorta in Patients With Aortic Valve Stenosis: A Prospective Serial 4D-Flow MRI Study. 国際誌査読有り

Hiroki Kamada, Hideki Ota, Masanori Nakamura, Yohsuke Imai, Shunichi Ishida, Wenyu Sun, Ko Sakatsume, Ichiro Yoshioka, Yoshikatsu Saiki, Kei Takase

Seminars in thoracic and cardiovascular surgery　32　(1)　25-34　2020年

DOI： 10.1053/j.semtcvs.2019.07.006 　

ISSN：1043-0679

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This study investigated hemodynamic changes in the thoracic aorta and aortic arch branches before and after aortic valve replacement (AVR) by 4D-flow MRI in patients with aortic valve stenosis (AS). Thoracic 4D-flow MRI was performed in 10 AS patients before and after AVR (mean 27 ± 1.9 days). Fifteen aortic planes and 3 aortic arch branches planes were set to evaluate the mean volume flow rate in each plane during a cardiac cycle and the angle between the main flow direction in a specified plane and the axial direction of the aorta. We also focused on the distribution and magnitude of helicity density to evaluate the flow complexity. A significant increase in the volume flow rate after AVR was found in the ascending aorta (before 59.2 ± 8.7 mL/s vs after 77.3 ± 6.2 mL/s, P < 0.05) and the aortic arch branches (before 26.5 ± 2.8 mL/s vs after 35.8 ± 3.3 mL/s, P < 0.001). The flow angle significantly decreased in the ascending aorta (before 39.2 ± 2.7 degree vs after 25.2 ± 1.7°, P < 0.0001) and the arch aorta (before 19.3 ± 2.0 degree vs after 13.4 ± 0.9°, P < 0.001). The volume flow rate in the ascending aorta and the arch branches increased within 1 month after AVR, showing an increased blood supply to the upper body, including to the brain. The postoperative change was accompanied with an increased blood flow in the ascending aorta and a decreased flow complexity proximal to the arch branches.
Insula Activity to Visceral Stimulation and Endocrine Stress Responses as Associated With Alexithymia in Patients With Irritable Bowel Syndrome. 国際誌査読有り

Michiko Kano, Tomohiko Muratsubaki, Mao Yagihashi, Joe Morishita, Shunji Mugikura, Patrick Dupont, Kei Takase, Motoyori Kanazawa, Lukas Van Oudenhove, Shin Fukudo

Psychosomatic medicine　82　(1)　29-38　2020年1月

DOI： 10.1097/PSY.0000000000000729 　

ISSN：0033-3174

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OBJECTIVE: Few studies have investigated associations between alexithymia and physiological mechanisms in psychosomatic diseases. We examined associations between alexithymia and 1) perception and brain processing of visceral stimulation and 2) the endocrine responses to corticotrophin-releasing hormone (CRH) in healthy individuals and patients with irritable bowel syndrome (IBS). METHODS: The study included 29 patients with IBS and 35 age- and sex-matched healthy controls (HCs). Alexithymia was measured using the 20-item Toronto Alexithymia Scale (TAS-20). Brain responses to rectal distention and its anticipation were measured by functional magnetic resonance imaging and analyzed at a voxel-level threshold of puncorrected < .001 combined with a cluster-level threshold of pFWE-corrected < .05. On a different day, plasma adrenocorticotropic hormone and cortisol responses after intravenous CRH administration were measured. RESULTS: TAS-20 scores did not differ significantly between patients with IBS and HCs (p = .18). TAS-20 scores correlated positively with the individual rectal discomfort thresholds (βrobust = 0.49, p = .03) and negatively with the rating of fear before rectal distention (βrobust = -1.63, p = .04) in patients with IBS but not in HCs. Brain responses to rectal distention in the right insula and other brain regions were positively associated with TAS-20 scores to a greater extent in patients with IBS than in HCs. Individuals with higher TAS-20 scores (both patients with IBS and HCs) demonstrated stronger adrenocorticotropic hormone responses to CRH administration (F(4,224) = 3.54, p = .008). CONCLUSION: Higher alexithymia scores are associated with stronger physiological responses, but lower anticipatory fear ratings and higher discomfort thresholds, particularly in patients with IBS.
Association of the incidence of venous air embolism on coronary computed tomography angiography with the intravenous access route preparation process. 査読有り

Kayano S, Ota H, Yamaguchi T, Ono K, Takase K

Medicine　98　(45)　e17940　2019年11月

DOI： 10.1097/MD.0000000000017940 　

ISSN：0025-7974

eISSN：1536-5964
CardioOncologyの現状と未来当院データと本邦における多施設共同研究への発展

杉村宏一郎, 大田英揮, 多田寛, 照井洋輔, 佐藤遥, 後岡広太郎, 石田孝宣, 高瀬圭, 下川宏明

日本心臓病学会学術集会抄録　67回　SS-3　2019年9月
出版者・発行元： (一社)日本心臓病学会
肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

佐々木健吾, 宮城重人, 笹嶋秀憲, 宮崎勇希, 藤尾淳, 西村隆一, 中西渉, 戸子台和哲, 大田英揮, 高瀬圭, 亀井尚, 海野倫明

移植　54　(総会臨時)　200-200　2019年9月
出版者・発行元： (一社)日本移植学会
ISSN：0578-7947

eISSN：2188-0034
頭部CT Angiographyを想定するヒストグラム解析を用いた撮影タイミングの決定法に関する基礎的検証

茅野伸吾, 藤盛陽介, 高野博和, 高根侑美, 大村知己, 千葉雄高, 大田英揮, 高瀬圭

日本放射線技術学会雑誌　75　(9)　1075-1075　2019年9月
出版者・発行元： (公社)日本放射線技術学会
ISSN：0369-4305

eISSN：1881-4883
ちょっと気になる胆・膵画像ティーチングファイルから(第42回) 肝内外に多発病変を認めた胆管内乳頭状腫瘍の1例

影山咲子, 大田英揮, 前川由依, 高浪健太郎, 藤島史喜, 高瀬圭

胆と膵　40　(8)　661-664　2019年8月
出版者・発行元：医学図書出版(株)
ISSN：0388-9408
新型FDG PETで多数の神経節に集積を認めたNeurolymphomatosisの一例

加藤恵里奈, 外山由貴, 太田瑛梨, 高橋梢, 前川由依, 加賀谷由里子, 村田隆紀, 斎藤美穂子, 高浪健太郎, 高瀬圭

核医学　56　(1)　101-101　2019年7月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
Ultrafast Dynamic Contrast-Enhanced Breast MRI: Kinetic Curve Assessment Using Empirical Mathematical Model Validated with Histological Microvessel Density 査読有り

Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Chiaki Takasawa, Satoko Sato, Minoru Miyashita, Yu Mori, Federico D. Pineda, Gregory S. Karczmar, Hajime Tamura, Shoki Takahashi, Kei Takase

Academic Radiology　26　(7)　e141-e149　2019年7月

DOI： 10.1016/j.acra.2018.08.016 　

ISSN：1076-6332

eISSN：1878-4046
Effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling: a preliminary study using computational fluid dynamics. 国際誌査読有り

Tomo Kinoshita, Kazumasa Seiji, Narendra Kurnia Putra, Tomohito Watanabe, Sho Matsumoto, Makoto Ohta, Kei Takase

Medical & biological engineering & computing　57　(7)　1425-1436　2019年7月

DOI： 10.1007/s11517-019-01968-1 　

ISSN：0140-0118

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This study aimed to evaluate the effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling. A three-dimensional fluid-structure interaction simulation was performed using commercial finite element software. A computational model of a vein with a catheter inserted into it was constructed. The outer and inner diameters of the vein were 0.9 mm and 0.6 mm, respectively, whereas those of the catheter were 0.6 mm and 0.5 mm, respectively. The velocity of the blood flow at the outlet was 85 mm/s. The pressure at the inlet was 0 Pa. The mesh consisted of approximately 660,000 elements. The effect of the number (0-4) and shape (no notch, 1/4 circular, 1/3 circular, semicircular, 2/3 circlecircular, and 3/4 circular) of the notches at the distal end of the microcatheter on the vein deformation when a suction pressure was applied was evaluated. The venous wall displacement was the smallest with the one-notch catheter, followed by the four-notch catheter, and was the smallest with the catheter having 1/4-circular notches, followed by the one with 1/3-circular notches. In conclusion, microcatheters having one notch and 1/4-circular notches reduce vein deformation and lead to successful segmental adrenal venous sampling. Graphical abstract Comparing catheters having different notch shapes.
Changes in quality of life after laparoscopic adrenalectomy for patients with primary aldosteronism: Prospective 2-year longitudinal cohort study in a Japanese tertiary center. 査読有り

Ishidoya S, Kawasaki Y, Namiki S, Morimoto R, Takase K, Ito A

International journal of urology : official journal of the Japanese Urological Association　26　(7)　752-753　2019年7月

DOI： 10.1111/iju.14016 　

ISSN：0919-8172
Usefulness of Diffusion-Weighted Magnetic Resonance Imaging Using Apparent Diffusion Coefficient Values for Diagnosis of Infantile Hemangioma. 査読有り

Saito M, Kitami M, Takase K

Journal of computer assisted tomography　43　(4)　563-567　2019年7月

DOI： 10.1097/RCT.0000000000000884 　

ISSN：0363-8715

eISSN：1532-3145
Validating an Empirical Mathematical Model for Dynamic Contrast-enhanced MR Imaging of Hand and Wrist Synovitis in Rheumatoid Arthritis: Correlation of Model Parameters with Clinical Disease Activity. 査読有り

Ochi J, Mori N, Mori Y, Mugikura S, Hitachi S, Itoi E, Takase K

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　19　(3)　176-183　2019年7月

DOI： 10.2463/mrms.mp.2019-0026 　

ISSN：1347-3182

eISSN：1880-2206
急速に進行したMyxoid型副腎皮質癌の一例

手塚雄太, 森本玲, 白鳥ベアタ, 尾股慧, 小野美澄, 工藤正孝, 五十嵐康宏, 大田英揮, 高瀬圭, 宮城重人, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　95　(Suppl.Update)　77-80　2019年6月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
A case of iatrogenic air bubbles in the left ventricle by coronary computed tomographic angiography. 国際誌査読有り

Kayano S, Takahashi A, Ota H, Takase K

Radiology case reports　14　(6)　687-691　2019年6月

DOI： 10.1016/j.radcr.2019.03.017 　
18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status. 国際誌査読有り

Yuta Tezuka, Yuto Yamazaki, Masaaki Kitada, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Koji Mitsuzuka, Akihiro Ito, Jun Nishikawa, Noriko Asai, Yasuhiro Nakamura, Celso E Gomez-Sanchez, Sadayoshi Ito, Mari Dezawa, Hironobu Sasano, Fumitoshi Satoh

Hypertension (Dallas, Tex. : 1979)　73　(6)　1283-1290　2019年6月

DOI： 10.1161/HYPERTENSIONAHA.118.12064 　

ISSN：0194-911X

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Peripheral 18-oxocortisol (18oxoF) level could contribute to the detection of aldosterone-producing adenoma (APA) in patients with primary aldosteronism. However, peripheral 18oxoF varies among such patients, which is a big drawback concerning its clinical application. We studied 48 cases of APA, 35 harboring KCNJ5 mutation, to clarify the significance of clinical and pathological parameters about peripheral 18oxoF. Peripheral 18oxoF concentration ranged widely from 0.50 to 183.13 ng/dL and correlated positively with intratumoral areas stained positively for steroidogenic enzymes ( P<0.0001). The peripheral 18oxoF level also correlated significantly with that of circulating aldosterone ( P<0.0001) but not with that of cortisol, a precursor of 18oxoF. However, a significant correlation was detected between peripheral 18oxoF and intratumoral glucocorticoids ( P<0.05). In addition, peripheral 18oxoF correlated positively with the number of hybrid cells double positive for 11β-hydroxylase and aldosterone synthase ( P<0.0001). Comparing between the cases with and those without KCNJ5 mutation, the KCNJ5-mutated group demonstrated a significantly higher concentration of peripheral 18oxoF (28.4±5.6 versus 3.0±0.9 ng/dL, P<0.0001) and a larger intratumoral environment including the hybrid cells ( P<0.001), possibly representing a deviation from normal aldosterone biosynthesis. After multivariate analysis, KCNJ5 mutation status turned out to be the most associated factor involved in 18oxoF synthesis in APA ( P<0.0001). Results of our present study first revealed that enhanced 18oxoF synthesis in APA could come from a functional deviation of aldosterone biosynthesis from the normal zona glomerulosa and the utility of peripheral 18oxoF measurement could be influenced by the prevalence of KCNJ5 mutation in an APA.
Parasympathetic activity correlates with subjective and brain responses to rectal distension in healthy subjects but not in non-constipated patients with irritable bowel syndrome. 国際誌査読有り

Michiko Kano, Makoto Yoshizawa, Keiji Kono, Tomohiko Muratsubaki, Joe Morishita, Lukas Van Oudenhove, Mao Yagihashi, Shunji Mugikura, Patrick Dupont, Kei Takase, Motoyori Kanazawa, Shin Fukudo

Scientific reports　9　(1)　7358-7358　2019年5月14日

DOI： 10.1038/s41598-019-43455-5 　

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The nociceptive and autonomic nervous systems (ANS) are significantly intertwined. Decoupling of these systems may occur in pathological pain conditions, including irritable bowel syndrome (IBS). We investigated ANS activity and its association with visceral perception and brain activity during rectal distention in 27 patients with non-constipated IBS and 33 controls by assessing heart rate variability (HRV) using electrocardiography at rest, before, and during colorectal distention. Brain responses to colorectal distention were measured using functional magnetic resonance imaging and correlated with individual ANS function parameters. The IBS group displayed blunted sympathovagal balance [low/high-frequency ratio (LF:HF) of HRV] in response to colorectal distention compared with controls (P = 0.003). In controls, basal parasympathetic tone (HF component of HRV) was significantly negatively correlated with toleration threshold to the rectal distention, but not in patients with IBS (group comparison P = 0.04). Further, a positive correlation between baseline HF values and neural responses to rectal distension was found in the right caudate, bilateral dorsolateral anterior cingulate cortex, and pregenual anterior cingulate cortex in the control group but not in the IBS group. The results indicate abnormal interactions between ANS activity and the brain mechanisms underlying visceral perception in patients with IBS.
Atrophy of the ipsilateral mammillary body in unilateral hippocampal sclerosis shown by thin-slice-reconstructed volumetric analysis. 国際誌査読有り

Yohei Morishita, Shunji Mugikura, Naoko Mori, Hajime Tamura, Shiho Sato, Toshiaki Akashi, Kazutaka Jin, Nobukazu Nakasato, Kei Takase

Neuroradiology　61　(5)　515-523　2019年5月

DOI： 10.1007/s00234-019-02158-4 　

ISSN：0028-3940

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PURPOSE: Conventional volumetric analysis could not detect ipsilateral atrophy of the mammillary body in patients with unilateral hippocampal sclerosis. By using thin-slice-reconstructed volumetric analysis, we investigated whether the mammillary body volume is smaller on the hippocampal sclerosis side than in healthy subjects or the non-hippocampal sclerosis side. METHODS: This retrospective study included 45 patients with unilateral hippocampal sclerosis and 30 healthy subjects. Three-dimensional T1WI of 1 mm thicknesses were oversampled to a thickness of 0.2 mm (thin-slice-reconstructed images), and the mammillary bodies were segmented manually to determine mammillary body volume on each side. Mammillary body volumes on the hippocampal sclerosis side were compared with those in healthy subjects or the non-hippocampal sclerosis side. RESULTS: In patients with right hippocampal sclerosis, right mammillary body volume was both significantly smaller than that in healthy subjects (30.3 ± 10.3 vs. 43.3 ± 8.07 mm3, P < 0.001) and significantly smaller than the left mammillary body volume in each patient (30.3 ± 10.3 vs. 41.4 ± 10.1 mm3, P < 0.001). Similarly, in patients with left hippocampal sclerosis, left mammillary body volume was both significantly smaller than that in healthy subjects (37.7 ± 11.2 vs. 47.0 ± 8.65 mm3, P < 0.001) and significantly smaller than right mammillary body volume in each patient (37.7 ± 11.2 vs. 42.5 ± 7.78 mm3, P = 0.044). CONCLUSIONS: In this study, thin-slice-reconstructed volumetric analysis showed that, in patients with unilateral hippocampal sclerosis, mammillary body volume on the hippocampal sclerosis side is smaller than that in healthy subjects and the non-hippocampal sclerosis side.
3T MRI evaluation of regional catecholamine-producing tumor-induced myocardial injury. 国際誌査読有り

Satoshi Higuchi, Hideki Ota, Takuya Ueda, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, Kei Takase

Endocrine connections　8　(5)　454-461　2019年5月1日

DOI： 10.1530/EC-18-0553 　

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Objective: Regional differences in cardiac magnetic resonance, which can reveal catecholamine-induced myocardial injury in patients with pheochromocytoma, have not yet been assessed using 3T magnetic resonance imaging. We evaluated these differences using myocardial T1-mapping and strain analysis. Design and Methods: We retrospectively reviewed 16 patients newly diagnosed with catecholamine-producing tumors (CPT group) and 16 patients with essential hypertension (EH group), who underwent cardiac magnetic resonance imaging between May 2016 and March 2018. We acquired 3T magnetic resonance cine and native T1-mapping images and performed feature-tracking-based strain analysis in the former. Results: Global cardiac function, morphology, global strain and peak strain rate were similar, but end-diastolic wall thickness differed between groups (CPT vs EH: 10.5 ± 1.7 vs 12.6 ± 2.8 mm; P < 0.05). Basal, but not apical, circumferential strain was significantly higher in the CPT than the EH group (19.4 ± 3.2 vs 16.8 ± 3.6 %; P < 0.05). Native T1 values were significantly higher in CPT than in EH patients, in both the basal septum (1307 ± 48 vs 1241 ± 45 ms; P < 0.01) and the apical septum (1377 ± 59 vs 1265 ± 58 ms; P < 0.01) mid-walls. In the CPT, but not in the EH group, native T1 values in the apical wall were significantly higher than those in the basal wall (P < 0.01). Conclusion: 3T magnetic resonance-based T1-mapping can sensitively detect subclinical catecholamine-induced myocardial injury; the influence of catecholamines may be greater in the apical than in the basal wall.
Diagnostic value of electric properties tomography (EPT) for differentiating benign from malignant breast lesions: comparison with standard dynamic contrast-enhanced MRI. 査読有り

Mori N, Tsuchiya K, Sheth D, Mugikura S, Takase K, Katscher U, Abe H

European radiology　29　(4)　1778-1786　2019年4月

DOI： 10.1007/s00330-018-5708-4 　

ISSN：0938-7994
Perfusion contrast-enhanced ultrasound to predict early lymph-node metastasis in breast cancer 査読有り

Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yumiko Kudo, Mikiko Suzuki, Li Li, Yu Mori, Shoki Takahashi, Kei Takase

Japanese Journal of Radiology　37　(2)　145-153　2019年2月20日

DOI： 10.1007/s11604-018-0792-6 　

ISSN：1867-1071

eISSN：1867-108X
慢性血栓塞栓性肺高血圧症の治療前後における肺野ヨードマップのヒストグラム解析

大田英揮, 高木英誠, 冨永循哉, 高瀬圭, 杉村宏一郎, 佐藤遙, 高木英誠

Japanese Journal of Radiology　37　(Suppl.)　3-3　2019年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
Pulmonary Lymphatic Perfusion Syndrome. 国際誌査読有り

Hirano T, Fujino N, Takase K, Ota H, Tanaka R, Saito R, Suzuki A, Okutomo K, Sato T, Kageyama S, Tamada T, Sugiura H, Ichinose M

American journal of respiratory and critical care medicine　199　(4)　529-530　2019年2月

DOI： 10.1164/rccm.201806-1125IM 　

ISSN：1073-449X
Efficacy of 4'-[methyl-11C] thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal cancer: a pilot study. 国際誌査読有り

Masatoshi Hotta, Ryogo Minamimoto, Kazuhiko Yamada, Kyoko Nohara, Daisuke Soma, Kazuhiko Nakajima, Jun Toyohara, Kei Takase

EJNMMI research　9　(1)　10-10　2019年1月30日

DOI： 10.1186/s13550-019-0478-9 　

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BACKGROUND: 4'-[Methyl-11C] thiothymidine (4DST) has been introduced as a new cell proliferation imaging PET tracer that incorporates into DNA directly. The aim of this prospective study was to evaluate the efficacy of 4DST PET/CT for predicting responses to neoadjuvant therapy in patients with esophageal cancer comparing with FDG PET/CT. METHODS: Twenty-six patients who had pre- and post-therapeutic 4DST and FDG PET/CT and underwent esophagectomy following neoadjuvant therapy were used for the analysis. Based on pathological findings, patients were divided into two groups: non-responders and responders. The maximum standardized uptake value (SUVmax), metabolic tumor volume, total lesion glycolysis, and total lesion proliferation of the primary lesion were measured for FDG and 4DST PET. RESULTS: The pathological diagnosis revealed 16 responders and 10 non-responders. Non-responders showed significantly higher 4DST post-therapeutic SUVmax (postSUVmax) than responders, whereas FDG postSUVmax showed no statistically significant difference (non-responders vs. responders: 4DST, 6.7 vs. 3.3, p = 0.001; FDG, 6.1 vs. 4.5, p = 0.11). Responders showed a greater reduction in percentage changes of 4DST and FDG SUVmax (ΔSUVmax) from baseline to post-therapeutic PET (non-responders vs. responders: 4DST, - 2.9% vs. - 56.7%, p < 0.001; FDG, - 36.3% vs. - 72.6%, p < 0.001). In ROC analysis, ΔSUVmax and postSUVmax with 4DST provided great diagnostic performance for predicting responses (area under the curve: 4DST ΔSUVmax = 0.92, 4DST postSUVmax = 0.88). CONCLUSIONS: 4DST PET/CT has a great potential for predicting pathologic response to neoadjuvant therapy in patients with esophageal cancer; it may be slightly superior to that with FDG PET/CT.
A multicenter trial of extracorporeal cardiac shock wave therapy for refractory angina pectoris: report of the highly advanced medical treatment in Japan. 査読有り

Yoku Kikuchi, Kenta Ito, Tomohiko Shindo, Kiyotaka Hao, Takashi Shiroto, Yasuharu Matsumoto, Jun Takahashi, Takao Matsubara, Akira Yamada, Yukio Ozaki, Michiaki Hiroe, Kazuo Misumi, Hideki Ota, Kentaro Takanami, Tomomichi Hiraide, Kei Takase, Fumiya Tanji, Yasutake Tomata, Ichiro Tsuji, Hiroaki Shimokawa

Heart and vessels　34　(1)　104-113　2019年1月

DOI： 10.1007/s00380-018-1215-4 　

ISSN：0910-8327

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We have previously demonstrated that cardiac shock wave therapy (CSWT) effectively improves myocardial ischemia through coronary neovascularization both in a porcine model of chronic myocardial ischemia and in patients with refractory angina pectoris (AP). In this study, we further addressed the efficacy and safety of CSWT in a single-arm multicenter study approved as a highly advanced medical treatment by the Japanese Ministry of Health, Labour and Welfare. Fifty patients with refractory AP [mean age 70.9 ± 12.6 (SD) years, M/F 38/12] without the indications of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were enrolled in 4 institutes in Japan. Ischemic myocardial regions in the left ventricle (LV) were identified by drug-induced stress myocardial perfusion imaging (MPI). Shock waves (200 shots/spot at 0.09 mJ/mm2) were applied to 40-60 spots in the ischemic myocardium 3 times in the first week. The patients were followed up for 3 months thereafter. Forty-one patients underwent CSWT and completed the follow-up at 3 months. CSWT markedly improved weekly nitroglycerin use [from 3.5 (IQR 2 to 6) to 0 (IQR 0 to 1)] and the symptoms [Canadian Cardiovascular Society functional class score, from 2 (IQR 2 to 3) to 1 (IQR 1 to 2)] (both P < 0.001). CSWT also significantly improved 6-min walking distance (from 384 ± 91 to 435 ± 122 m, P < 0.05). There were no significant changes in LV ejection fraction evaluated by echocardiography and LV stroke volume evaluated by cardiac magnetic resonance imaging (from 56.3 ± 14.7 to 58.8 ± 12.8%, P = 0.10, and from 52.3 ± 17.4 to 55.6 ± 15.7 mL, P = 0.15, respectively). Percent myocardium ischemia assessed by drug-induced stress MPI tended to be improved only in the treated segments (from 16.0 ± 11.1 to 12.1 ± 16.2%, P = 0.06), although no change was noted in the whole LV. No procedural complications or adverse effects related to the CSWT were noted. These results of the multicenter trial further indicate that CSWT is a useful and safe non-invasive strategy for patients with refractory AP with no options of PCI or CABG.
Time to Face the Nightmare That Has Plagued Neurosurgeons for Years: Memory Impairment from Postsurgery Subcallosal Artery Infarction for Anterior Communicating Artery Aneurysms. 国際誌査読有り

Mugikura S, Takahashi S, Takase K

World neurosurgery　121　280-281　2019年1月

DOI： 10.1016/j.wneu.2018.08.224 　

ISSN：1878-8750
Correlation between the native lung volume change and postoperative pulmonary function after single lung transplantation for lymphangioleiomyomatosis: Evaluation of lung volume by three-dimensional computed tomography volumetry. 国際誌査読有り

Suzuki H, Oishi H, Noda M, Watanabe T, Matsuda Y, Tominaga J, Sado T, Sakurada A, Kurosawa H, Takase K, Okada Y

PloS one　14　(2)　e0210975　2019年

DOI： 10.1371/journal.pone.0210975 　
Influence of renal function and demographic data on intrarenal Doppler ultrasonography. 国際誌査読有り

Michiaki Abe, Tetsuya Akaishi, Takashi Miki, Mika Miki, Yasuharu Funamizu, Kaori Araya, Kota Ishizawa, Shin Takayama, Kei Takase, Takaaki Abe, Tadashi Ishii, Sadayoshi Ito

PloS one　14　(8)　e0221244　2019年

DOI： 10.1371/journal.pone.0221244 　

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Intrarenal Doppler ultrasonography is a non-invasive method to evaluate the renal blood flow in patients with renal arterial stenosis as well as chronic kidney diseases (CKD). Until recently, the relationship between ultrasonography findings and CKD stage has not been fully understood. Overall, 162 patients with CKD without apparent renal arterial stenosis were included in this study, and the pulsed-wave Doppler ultrasonography findings were evaluated in terms of the following parameters: peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) at the renal arterial trunk, hilum, segmental, and interlobar regions. Age showed a significant negative correlation with the estimated glomerular filtration rate (eGFR), kidney size, and aortic PSV. Additionally, age showed a significant positive correlation with RI in all 4 regions. The eGFR showed a positive correlation with the aortic PSV and kidney size, but a negative correlation with RI. Both age and eGFR were found to be independently associated with aortic blood flow. On the intrarenal ultrasound, EDV and RI showed stronger correlations with eGFR than PSV, suggesting that the former indices would be better markers of renal function. In particular, the interlobar EDV was found to be the best index that reflects renal function. Although the RI is also a good marker of renal function, it is confounded by age; thus, its utility would be weaker than that of the EDV. In conclusion, intrarenal pulsed-wave Doppler ultrasonography is a useful tool to estimate and evaluate the renal function; the interlobar EDV may be the best index to estimate the effective perfusion and filtration of the kidneys.
当院における塩化ラジウム(223Ra)の初期経験

太田瑛梨, 鎌田裕基, 外山由貴, 齋藤美穂子, 高浪健太郎, 高瀬圭, 高橋紀善, 石川陽二郎, 山本貴也, 梅澤玲, 松下晴雄, 神宮啓一

核医学　55　(1)　37-37　2018年12月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
FDG-PETで高集積を呈した稀な腹壁病変の一例

樋口慧, 外山由貴, 前川由衣, 齋藤美穂子, 高浪健太郎, 高瀬圭, 植松智海, 佐藤聡子

核医学　55　(1)　41-41　2018年12月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
先端巨大症合併膝関節症に対して下垂体手術がもたらす効果膝関節MRIを用いた22症例の解析

祢津昌広, 工藤正孝, 森本玲, 手塚雄太, 小野美澄, 尾股慧, 五十嵐康宏, 常陸真, 高瀬圭, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　94　(3)　873-873　2018年12月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
アルドステロン産生腺腫合併例における腎組織障害

手塚雄太, 尾形博子, 森本玲, 工藤正孝, 五十嵐康宏, 高瀬圭, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　94　(4)　1572-1572　2018年12月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
当科における転移性副腎腫瘍に対する診療実績

工藤正孝, 手塚雄太, 森本玲, 祢津昌広, 五十嵐康宏, 清治和将, 高瀬圭, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　94　(4)　1597-1597　2018年12月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
最新半導体PETにおける上腹部病変への呼吸同期の有用性

外山由貴, 高浪健太郎, 太田瑛梨, 加賀谷由里子, 前川由依, 齊藤美穂子, 高瀬圭

核医学　55　(Suppl.)　S208-S208　2018年11月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
Traumatic midline subarachnoid hemorrhage on initial computed tomography as a marker of severe diffuse axonal injury. 国際誌査読有り

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi, Kei Takase

Journal of neurosurgery　129　(5)　1317-1324　2018年11月1日

DOI： 10.3171/2017.6.JNS17466 　

ISSN：0022-3085

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OBJECTIVEThe objective of this study was to test the hypothesis that midline (interhemispheric or perimesencephalic) traumatic subarachnoid hemorrhage (tSAH) on initial CT may implicate the same shearing mechanism that underlies severe diffuse axonal injury (DAI).METHODSThe authors enrolled 270 consecutive patients (mean age [± SD] 43 ± 23.3 years) with a history of head trauma who had undergone initial CT within 24 hours and brain MRI within 30 days. Six initial CT findings, including intraventricular hemorrhage (IVH) and tSAH, were used as candidate predictors of DAI. The presence of tSAH was determined at the cerebral convexities, sylvian fissures, sylvian vallecula, cerebellar folia, interhemispheric fissure, and perimesencephalic cisterns. Following MRI, patients were divided into negative and positive DAI groups, and were assigned to a DAI stage: 1) stage 0, negative DAI; 2) stage 1, DAI in lobar white matter or cerebellum; 3) stage 2, DAI involving the corpus callosum; and 4) stage 3, DAI involving the brainstem. Glasgow Outcome Scale-Extended (GOSE) scores were obtained in 232 patients.RESULTSOf 270 patients, 77 (28.5%) had DAI; tSAH and IVH were independently associated with DAI (p < 0.05). Of tSAH locations, midline tSAH was independently associated with both overall DAI and DAI stage 2 or 3 (severe DAI; p < 0.05). The midline tSAH on initial CT had sensitivity of 60.8%, specificity of 81.7%, and positive and negative predictive values of 43.7% and 89.9%, respectively, for severe DAI. When adjusted for admission Glasgow Coma Score, the midline tSAH independently predicted poor GOSE score at both hospital discharge and after 6 months.CONCLUSIONSMidline tSAH could implicate the same shearing mechanism that underlies severe DAI, for which midline tSAH on initial CT is a probable surrogate.
Left Ventricular T1 Mapping during Chemotherapy-Radiation Therapy: Serial Assessment of Participants with Esophageal Cancer. 国際誌査読有り

Takagi H, Ota H, Umezawa R, Kimura T, Kadoya N, Higuchi S, Sun W, Nakajima Y, Saito M, Komori Y, Jingu K, Takase K

Radiology　289　(2)　347-354　2018年11月

DOI： 10.1148/radiol.2018172076 　

ISSN：0033-8419
Effects of surgical treatment for acromegaly on knee MRI structural features. 査読有り

Masahiro Nezu, Masataka Kudo, Ryo Morimoto, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Yasuhiro Igarashi, Shin Hitachi, Kei Takase, Sadayoshi Ito, Fumitoshi Satoh

Endocrine journal　65　(10)　991-999　2018年10月29日

DOI： 10.1507/endocrj.EJ18-0108 　

ISSN：0918-8959

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Acromegalic arthropathy is a common complication of acromegaly and harms the quality of life of the patients even after acromegaly is in long-term remission. A recent study demonstrated by knee MRI the characteristic structural features of acromegalic arthropathy. However, the effects of treatment for acromegaly on such structural features are almost unknown. This study was undertaken to analyze the effects of transsphenoidal surgery (TSS) on acromegalic arthropathy and elucidate whether knee MRI findings are reversible or irreversible. We analyzed 22 patients with acromegaly (63.7% females, median age 58 years) by knee MRI at diagnosis. Out of these 22 patients, 16 who underwent TSS (68.9% female, median age 58 years) were also subjected to knee MRI 2 months after TSS. As for X-ray undetectable findings, MRI detected synovial thickening, bone marrow lesion, ligament injury and meniscus injury in 22.7%, 22.7%, 4.7% and 59.1% of the patients, respectively. With respect to the 16 patients who underwent TSS, clinical and structural improvements were observed respectively in 100%, 66.7% and 66.7% of the patients who showed knee joint pain, synovial thickening and bone marrow lesion before TSS. However, no patient showed structural improvement of meniscus injury after TSS. In acromegalic arthropathy, synovial thickening and bone marrow lesions are reversible while meniscus injury is irreversible. Because all those findings are associated with the exacerbation of arthropathy, they may be therapeutic targets for preventing the progression of arthropathy by endocrinological and orthopedic intervention.
Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy. 査読有り

Kozumi M, Ota H, Yamamoto T, Umezawa R, Matsushita H, Ishikawa Y, Takahashi N, Matsuura T, Takase K, Jingu K

European radiology　28　(10)　4296-4305　2018年10月

DOI： 10.1007/s00330-018-5439-6 　

ISSN：0938-7994
抗血栓療法を要する原発性アルドステロン症の臨床的特徴の解明

工藤正孝, 森本玲, 手塚雄太, 尾股慧, 白鳥ベアタ, 五十嵐康弘, 清治和将, 高瀬圭, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　41回　OC05-06　2018年9月
出版者・発行元： (NPO)日本高血圧学会
Rapid Development of New Aneurysms in the Adjacent Pancreatic Arcade Arteries after Urgent Embolization of Pancreaticoduodenal Artery Aneurysms in Cases with Celiac Stenosis. 査読有り

Hasegawa T, Seiji K, Ota H, Matsuura T, Satani N, Sato T, Takase K

Journal of vascular and interventional radiology : JVIR　29　(9)　1306-1308.e2　2018年9月
出版者・発行元：
DOI： 10.1016/j.jvir.2018.04.003 　

ISSN：1051-0443
[Imaging Diagnosis and Interventional Radiology for Thoracic Surgery]. 査読有り

Takase K

Kyobu geka. The Japanese journal of thoracic surgery　71　(10)　747-754　2018年9月

ISSN：0021-5252
褐色細胞腫患者における心筋T1 mappingを用いたカテコラミン心筋障害の評価

樋口慧, 大田英揮, 手塚雄太, 祢津昌広, 森本玲, 高瀬圭

日独医報　63　(1)　81-81　2018年7月
出版者・発行元：バイエル薬品(株)
ISSN：0912-0351
Treatment Effect of Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension Quantified by Automatic Comparative Imaging in Computed Tomography Pulmonary Angiography 査読有り

Zhiwei Zhai, Hideki Ota, Marius Staring, Jan Stolk, Koichiro Sugimura, Kei Takase, Berend C. Stoel

Investigative Radiology　53　(5)　286-292　2018年5月1日
出版者・発行元： Lippincott Williams and Wilkins
DOI： 10.1097/RLI.0000000000000441 　

ISSN：1536-0210 0020-9996
Relationship Between Perforator Infarction and Patient Outcomes After Surgical Treatment of Ruptured Anterior Communicating Artery Aneurysms. 査読有り

Mugikura S, Fujimura M, Takahashi S, Takase K

World neurosurgery　113　390-391　2018年5月

DOI： 10.1016/j.wneu.2018.01.161 　

ISSN：1878-8750
Renovascular hypertension associated with JAK2 V617F positive myeloproliferative neoplasms treated with angioplasty: 2 cases and literature review. 国際誌査読有り

Eikan Mishima, Takehiro Suzuki, Yoichi Takeuchi, Kazumasa Seiji, Noriko Fukuhara, Kei Takase, Hideo Harigae, Takaaki Abe, Sadayoshi Ito

Journal of clinical hypertension (Greenwich, Conn.)　20　(4)　798-804　2018年4月

DOI： 10.1111/jch.13257 　

ISSN：1524-6175

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Myeloproliferative neoplasms (MPNs) with Janus kinase 2 (JAK2) mutation are associated with a high risk for occlusive vascular diseases. We report 2 cases of renovascular hypertension associated with JAK2 V617F mutation-positive MPNs and provide a literature review. In Case 1, a 63-year-old woman had resistant hypertension, massive proteinuria, and erythrocytosis. Evaluations revealed right renal artery stenosis causing renovascular hypertension and polycythemia vera with JAK2 V617F mutation. Renin-angiotensin system inhibitors and subsequent angioplasty controlled the blood pressure and the proteinuria resolved. In Case 2, a 74-year-old woman had resistant hypertension and thrombocytosis. Evaluations confirmed left renal artery stenosis and essential thrombocythemia with JAK2 V617F. Angioplasty cured the hypertension. A literature review of 18 cases revealed the following as the most common characteristics of MPN-associated renovascular hypertension: manifests primarily in women; is associated with untreated polycythemia vera and essential thrombocythemia, concomitant leukocytosis, and JAK2 mutation positivity; and is responsive to angioplasty. This report demonstrates that JAK2 mutation-positive MPNs are a less common but important underlying cause of adult renovascular hypertension.
Anthracycline系による治療を受けた癌患者の管理における心臓MRIの有用性腫瘍循環器学の進歩(Usefulness of Cardiac MRI in the Management of Cancer Patients Treated with Anthracyclines: Progress in Cardiooncology)

照井洋輔, 杉村宏一郎, 大田英揮, 佐藤遥, 後岡広太郎, 建部俊介, 青木竜男, 山本沙織, 神津克也, 紺野亮, 高瀬圭, 下川宏明

日本循環器学会学術集会抄録集　82回　OJ02-4　2018年3月
出版者・発行元： (一社)日本循環器学会
右鼠径部-大陰唇の膨隆を呈し、臨床的に鼠径ヘルニアや水腫が疑われた小児症例

樋口慧, 北見昌広, 齋藤美穂子, 高瀬圭, 西功太郎, 袴塚崇, 古田明美

Japanese Journal of Radiology　36　(Suppl.)　14-14　2018年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
縦隔の悪性Solitary Fibrous Tumorの1例

村中美千帆, 冨永循哉, 高瀬圭, 桜田晃, 齊藤涼子

Japanese Journal of Radiology　36　(Suppl.)　16-16　2018年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
Usefulness of the S–O clip for gastric endoscopic submucosal dissection (with video) 査読有り

Rintaro Hashimoto, Dai Hirasawa, Tomoyuki Iwaki, Hajime Yamaoka, Kousuke Nihei, Ippei Tanaka, Akimichi Chonan, Kei Takase

Surgical Endoscopy and Other Interventional Techniques　32　(2)　908-914　2018年2月1日
出版者・発行元： Springer New York LLC
DOI： 10.1007/s00464-017-5765-9 　

ISSN：1432-2218 0930-2794
Subcallosal and Heubner artery infarcts following surgical repair of an anterior communicating artery aneurysm: a causal relationship with postoperative amnesia and long-term outcome 査読有り

Shunji Mugikura, Hirokazu Kikuchi, Miki Fujimura, Etsuro Mori, Shoki Takahashi, Kei Takase

Japanese Journal of Radiology　36　(2)　81-89　2018年2月1日
出版者・発行元： Springer Tokyo
DOI： 10.1007/s11604-017-0703-2 　

ISSN：1867-108X 1867-1071
Coronary Adventitial and Perivascular Adipose Tissue Inflammation in Patients With Vasospastic Angina. 国際誌査読有り

Ohyama K, Matsumoto Y, Takanami K, Ota H, Nishimiya K, Sugisawa J, Tsuchiya S, Amamizu H, Uzuka H, Suda A, Shindo T, Kikuchi Y, Hao K, Tsuburaya R, Takahashi J, Miyata S, Sakata Y, Takase K, Shimokawa H

Journal of the American College of Cardiology　71　(4)　414-425　2018年1月30日

DOI： 10.1016/j.jacc.2017.11.046 　

ISSN：0735-1097
Image quality and radiation dose of low-tube-voltage CT with reduced contrast media for right adrenal vein imaging. 国際誌査読有り

Yuki Takahashi, Hideki Ota, Kensuke Omura, Yutaka Dendo, Katharina Otani, Tomonori Matsuura, Masahiro Kitami, Kazumasa Seiji, Yuta Tezuka, Masahiro Nezu, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

European journal of radiology　98　150-157　2018年1月

DOI： 10.1016/j.ejrad.2017.11.017 　

ISSN：0720-048X

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OBJECTIVES: To compare image quality and radiation dose of right adrenal vein (RAV) imaging computed tomography (CT) among conventional, low kV, and low kV with reduced contrast medium protocols. METHODS: One-hundred-and-twenty patients undergoing adrenal CT were randomly assigned to one of three protocols: contrast dose of 600mgI/kg at 120-kV tube voltage setting (600-120 group), 600mgI/kg at 80kV (600-80 group), and 360mgI/kg at 80kV (360-80 group). Iterative reconstruction was used for 80-kV groups. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the RAV and size-specific dose estimates (SSDE) were measured. Three radiologists evaluated 4-point visualisation scores of RAV by consensus reading. RESULTS: The RAV detectability was 95%, 97.2%, and 97.3% for 600-120, 600-80, and 360-80 groups, respectively (p=1.000). Visualisation scores were not significantly different among the groups (p=0.152). There were no significant differences in CNR or SNR between the 600-120 and 360-80 groups. SSDE of the 360-80 group was significantly lower than that of the 600-120 group (5.86mGy±1.44 vs. 7.27mGy±1.81, p<0.001). CONCLUSIONS: 80-kV scans with 360 mgI/kg contrast media showed comparable detectability of RAV to conventional scans, while reducing 19% of SSDE.
Influence of Uncertain Anticipation on Brain Responses to Aversive Rectal Distension in Patients With Irritable Bowel Syndrome 査読有り

Michiko Kano, Tomohiko Muratsubaki, Joe Morishita, Keiji Kono, Shunji Mugikura, Kei Takase, Huynh Giao Ly, Patrick Dupont, Lukas Van Oudenhove, Shin Fukudo

PSYCHOSOMATIC MEDICINE　79　(9)　988-999　2017年11月

DOI： 10.1097/PSY.0000000000000484 　

ISSN：0033-3174

eISSN：1534-7796
Fear of linear gadolinium-based contrast agents and the Japanese radiologist's choice 査読有り

Shunji Mugikura, Kei Takase

JAPANESE JOURNAL OF RADIOLOGY　35　(11)　695-696　2017年11月

DOI： 10.1007/s11604-017-0682-3 　

ISSN：1867-1071

eISSN：1867-108X
The re-emerging importance of radiologic-pathologic correlation in reaching the pathology diagnosis 査読有り

Monica Sze Man Chan, Ryoko Saito, Kei Takase, Yasuhiro Nakamura, Hironobu Sasano

PATHOLOGY INTERNATIONAL　67　(11)　537-538　2017年11月

DOI： 10.1111/pin.12599 　

ISSN：1320-5463

eISSN：1440-1827
Clinical utility of texture analysis of 18F-FDG PET/CT in patients with Stage I lung cancer treated with stereotactic body radiotherapy 査読有り

Kazuya Takeda, Kentaro Takanami, Yuko Shirata, Takaya Yamamoto, Noriyoshi Takahashi, Kengo Ito, Kei Takase, Keiichi Jingu

JOURNAL OF RADIATION RESEARCH　58　(6)　862-869　2017年11月

DOI： 10.1093/jrr/rrx050 　

ISSN：0449-3060

eISSN：1349-9157
無症候性原発性副甲状腺機能亢進症の一例

手塚雄太, 森本玲, 祢津昌広, 五十嵐康宏, 工藤正孝, 高瀬圭, 中島範昭, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　93　(2)　565-565　2017年10月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
Selective embolization therapy for intrarenal artery stenosis causing renovascular hypertension: Efficacy and follow-up renal imaging 査読有り

Eikan Mishima, Takehiro Suzuki, Kazumasa Seiji, Yasutoshi Akiyama, Hideki Ota, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito

JOURNAL OF CLINICAL HYPERTENSION　19　(10)　1028-1031　2017年10月

DOI： 10.1111/jch.13040 　

ISSN：1524-6175

eISSN：1751-7176
Native T1値と細胞外容積分画を用いた放射線心筋障害の評価

高木英誠, 大田英揮, 梅沢玲, 神宮啓一, 高瀬圭

日独医報　62　(1)　82-82　2017年9月
出版者・発行元：バイエル薬品(株)
ISSN：0912-0351
Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome 査読有り

Michiko Kano, Tomohiko Muratsubaki, Lukas Van Oudenhove, Joe Morishita, Makoto Yoshizawa, Keiji Kohno, Mao Yagihashi, Yukari Tanaka, Shunji Mugikura, Patrick Dupont, Huynh Giao Ly, Kei Takase, Motoyori Kanazawa, Shin Fukudo

SCIENTIFIC REPORTS　7　(1)　12425　2017年9月

DOI： 10.1038/s41598-017-09635-x 　

ISSN：2045-2322
Ischemic White Matter Lesions Associated With Medullary Arteries: Classification of MRI Findings Based on the Anatomic Arterial Distributions 査読有り

Toshiaki Akashi, Shoki Takahashi, Shunji Mugikura, Shiho Sato, Takaki Murata, Atsushi Umetsu, Kei Takase

AMERICAN JOURNAL OF ROENTGENOLOGY　209　(3)　W160-W168　2017年8月

DOI： 10.2214/AJR.16.17231 　

ISSN：0361-803X

eISSN：1546-3141
For Whom Should We Write a Radiology Report, an Attending Physician or a Patient? 査読有り

Shunji Mugikura, Keisei Fujimori, Kei Takase

AMERICAN JOURNAL OF ROENTGENOLOGY　209　(3)　W199-W199　2017年8月

DOI： 10.2214/AJR.17.18150 　

ISSN：0361-803X

eISSN：1546-3141
Further Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan. 査読有り

Mugikura S, Fujimura M, Takahashi S, Takase K

Radiology　284　(1)　301-303　2017年7月

DOI： 10.1148/radiol.2017170252 　

ISSN：0033-8419
二次性高血圧を見逃さない原発性アルドステロン症診断治療のUpdate

佐藤文俊, 森本玲, 手塚雄太, 尾股慧, 祢津昌広, 小野美澄, 岩倉芳倫, 五十嵐康宏, 工藤正孝, 高瀬圭, 笹野公伸, 伊藤貞嘉

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　6回　103-103　2017年5月
出版者・発行元： (NPO)日本高血圧学会
副腎静脈サンプリングにて片側副腎摘除の適応と判定したが、最終的に薬物療法での加療を選択された症例についての報告

工藤正孝, 森本玲, 岩倉芳倫, 小野美澄, 手塚雄太, 祢津昌広, 五十嵐康宏, 清治和将, 高瀬圭, 伊藤貞嘉, 佐藤文俊

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　6回　156-156　2017年5月
出版者・発行元： (NPO)日本高血圧学会
生体肝移植後の肝静脈血栓閉塞に対し、バルーン拡張と経カテーテルウロキナーゼ投与が奏功した一例

円城寺康宏, 大田英揮, 清治和将, 高瀬圭, 横沢友樹, 中西史, 宮城重人

IVR: Interventional Radiology　32　(Suppl.)　286-286　2017年4月
出版者・発行元： (一社)日本インターベンショナルラジオロジー学会
ISSN：1340-4520

eISSN：2185-6451
Coil embolization of left ventricular outflow tract pseudoaneurysms: techniques and 5-year results 査読有り

Hideki Ota, Yoshiaki Morita, Yoshikatsu Saiki, Kei Takase

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY　24　(4)　631-633　2017年4月

DOI： 10.1093/icvts/ivw394 　

ISSN：1569-9293

eISSN：1569-9285
早期治療にて日和見感染症を管理し得たCushing病の一例

手塚雄太, 森本玲, 工藤正孝, 祢津昌広, 小野美澄, 五十嵐康宏, 高瀬圭, 井下尚子, 山田正三, 伊藤貞嘉, 佐藤文俊

ACTH RELATED PEPTIDES　28　8-10　2017年3月
出版者・発行元：間脳・下垂体・副腎系研究会
ISSN：1340-4512
Anderson-Fabry病の患者における心臓病変に対する新たな診断戦略(Novel Diagnostic Strategy for Cardiac Involvement in Patients with Anderson-Fabry Disease)

山本沙織, 杉村宏一郎, 鈴木秀明, 建部俊介, 青木竜男, 矢尾板信裕, 佐藤遥, 神津克也, 大田英揮, 高浪健太郎, 高瀬圭, 佐藤公雄, 下川宏明

日本循環器学会学術集会抄録集　81回　OJ-053　2017年3月
出版者・発行元： (一社)日本循環器学会
Quantitative Analysis of Contrast-Enhanced Ultrasound Imaging in Invasive Breast Cancer: A Novel Technique to Obtain Histopathologic Information of Microvessel Density 査読有り

Naoko Mori, Shunji Mugikura, Shoki Takahashi, Koichi Ito, Chiaki Takasawa, Li Li, Minoru Miyashita, Atsuko Kasajima, Yu Mori, Takanori Ishida, Tetsuya Kodama, Kei Takase

Ultrasound in Medicine and Biology　43　(3)　607-614　2017年3月1日

DOI： 10.1016/j.ultrasmedbio.2016.11.009 　

ISSN：0301-5629

eISSN：1879-291X
Anatomical Variations of the Right Adrenal Vein Concordance Between Multidetector Computed Tomography and Catheter Venography 査読有り

Kensuke Omura, Hideki Ota, Yuuki Takahashi, Tomonori Matsuura, Kazumasa Seiji, Yoichi Arai, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

HYPERTENSION　69　(3)　428-+　2017年3月

DOI： 10.1161/HYPERTENSIONAHA.116.08375 　

ISSN：0194-911X

eISSN：1524-4563
数年を経て確定診断に至った骨原発悪性リンパ腫の3例

木下知, 常陸真, 榊原宏幸, 森下陽平, 高橋祐輝, 野村脩子, 加賀谷由里子, 長谷川哲也, 佐藤嘉尚, 佐藤友美, 嶋内亜希子, 森菜緒子, 松浦智徳, 大田英揮, 北見昌広, 冨永循哉, 清治和将, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　1-1　2017年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
肝腫瘍への定位照射を目的としたCTガイド下金マーカー留置術における合併症の検討

高橋祐輝, 松浦智徳, 榊原宏幸, 森下陽平, 加賀谷由里子, 野村脩子, 木下知, 長谷川哲也, 佐藤嘉尚, 嶋内亜希子, 森菜緒子, 大田英揮, 常陸真, 北見昌広, 冨永循哉, 清治和将, 高瀬圭, 神宮啓一, 小川芳弘

Japanese Journal of Radiology　35　(Suppl.)　2-2　2017年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
自然縮小した胸腺腫の1例

大山翼, 袴塚崇, 榊原宏幸, 森下陽平, 伊藤幸, 高橋祐輝, 野村脩子, 大村健介, 前川由衣, 加賀谷由里子, 長谷川哲也, 木下知, 佐藤嘉尚, 外山由貴, 冨永循哉, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　8-8　2017年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
冠状動脈-肺動脈瘻に合併した動脈瘤に対する塞栓術の1例

榊原宏幸, 大田英揮, 伊藤幸, 森下陽平, 高橋祐輝, 大村健介, 野村脩子, 加賀谷由里子, 前川由依, 木下知, 長谷川哲也, 佐藤嘉尚, 外山由貴, 佐藤友美, 嶋内亜希子, 森菜緒子, 松浦智徳, 北見昌広, 常陸真, 齊藤美穂子, 冨永循哉, 清治和将, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　8-8　2017年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
胆嚢悪性リンパ腫の1例

森下陽平, 長谷川哲也, 伊藤幸, 榊原宏幸, 高橋祐輝, 大村健介, 野村脩子, 加賀谷由里子, 前川由依, 木下知, 佐藤嘉尚, 外山由貴, 佐藤友美, 嶋内亜希子, 森菜緒子, 松浦智徳, 大田英揮, 北見昌広, 常陸真, 齊藤美穂子, 冨永循哉, 清治和将, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　10-10　2017年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
Endovascular Treatment of Hepatic Artery Pseudoaneurysm after Pancreaticoduodenectomy: Risk Factors Associated with Mortality and Complications 査読有り

Tetsuya Hasegawa, Hideki Ota, Tomonori Matsuura, Kazumasa Seiji, Shunji Mugikura, Fuyuhiko Motoi, Michiaki Unno, Kei Takase

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　28　(1)　50-59　2017年1月

DOI： 10.1016/j.jvir.2016.04.004 　

ISSN：1051-0443

eISSN：1535-7732
Focal Reduction in Cardiac I-123-Metaiodobenzylguanidine Uptake in Patients With Anderson-Fabry Disease 査読有り

Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Shunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Haruka Sato, Katuya Kozu, Hideki Ota, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

CIRCULATION JOURNAL　80　(12)　2550-+　2016年12月

DOI： 10.1253/circj.CJ-16-0690 　

ISSN：1346-9843

eISSN：1347-4820
重症高Ca血症の是正に難渋した原発性副甲状腺機能亢進症の一例

手塚雄太, 森本玲, 小野美澄, 岩倉芳倫, 工藤正孝, 祢津昌広, 尾股慧, 五十嵐康宏, 中島範昭, 高瀬圭, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　92　(2)　507-507　2016年10月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
透析中の血圧管理に難渋した副腎内傍神経節腫合併血液透析症例

手塚雄太, 森本玲, 秋保真穂, 藤倉恵美, 祢津昌広, 小野美澄, 五十嵐康宏, 工藤正孝, 高瀬圭, 荒井陽一, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　92　(2)　521-521　2016年10月
出版者・発行元： (一社)日本内分泌学会
ISSN：0029-0661

eISSN：2186-506X
T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus 査読有り

Shiho Sato, Masaki Iwasaki, Hiroyoshi Suzuki, Shunji Mugikura, Kazutaka Jin, Teiji Tominaga, Kei Takase, Shoki Takahashi, Nobukazu Nakasato

EPILEPSY RESEARCH　126　1-9　2016年10月

DOI： 10.1016/j.eplepsyres.2016.06.001 　

ISSN：0920-1211

eISSN：1872-6844
わずかな領域の腎虚血が高血圧の原因となった分枝型腎血管性高血圧の1例高血圧の病態形成に限局性腎虚血が与える影響

三島英換, 鈴木健弘, 菊地晃一, 島久登, 清治和将, 高瀬圭, 阿部高明, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　39回　390-390　2016年9月
出版者・発行元： (NPO)日本高血圧学会
腎動脈狭窄による腎虚血診断のためのDiffusion-weighted MRIの有用性と臨床応用性の検討

三島英換, 大田英揮, 鈴木健弘, 菊地晃一, 島久登, 橋本潤一郎, 高瀬圭, 阿部高明, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　39回　358-358　2016年9月
出版者・発行元： (NPO)日本高血圧学会
片側性原発性アルドステロン症における術後アウトカムの検討 lateralization indexによる層別化

森本玲, 小野美澄, 祢津昌広, 尾股慧, 手塚雄太, 五十嵐康宏, 工藤正孝, 高瀬圭, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　39回　368-368　2016年9月
出版者・発行元： (NPO)日本高血圧学会
Dual-energy CT to estimate clinical severity of chronic thromboembolic pulmonary hypertension: Comparison with invasive right heart catheterization 査読有り

Hidenobu Takagi, Hideki Ota, Koichiro Sugimura, Katharina Otani, Junya Tominaga, Tatsuo Aoki, Shunsuke Tatebe, Masanobu Miura, Saori Yamamoto, Haruka Sato, Nobuhiro Yaoita, Hideaki Suzuki, Hiroaki Shimokawa, Kei Takase

EUROPEAN JOURNAL OF RADIOLOGY　85　(9)　1574-1580　2016年9月

DOI： 10.1016/j.ejrad.2016.06.010 　

ISSN：0720-048X

eISSN：1872-7727
Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension 査読有り

Haruka Sato, Hideki Ota, Koichiro Sugimura, Tatsuo Aoki, Shunsuke Tatebe, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Hideaki Suzuki, Kimio Satoh, Kei Takase, Hiroaki Shimokawa

CIRCULATION JOURNAL　80　(6)　1470-1477　2016年6月

DOI： 10.1253/circj.CJ-15-1187 　

ISSN：1346-9843

eISSN：1347-4820
中心静脈路確保困難に対しalternative central vein routeアプローチで中心静脈カテーテルを留置した3例

榊原宏幸, 清治和将, 大山翼, 森下陽平, 高橋祐輝, 野村脩子, 加賀谷由里子, 長谷川哲也, 佐藤嘉尚, 佐藤友美, 松浦智徳, 大田英揮, 冨永循哉, 高瀬圭

IVR: Interventional Radiology　31　(Suppl.)　160-160　2016年4月
出版者・発行元： (一社)日本インターベンショナルラジオロジー学会
ISSN：1340-4520

eISSN：2185-6451
Detection of Segmental Renal Ischemia by Diffusion-Weighted Magnetic Resonance Imaging: Clinical Utility for Diagnosis of Renovascular Hypertension 査読有り

Eikan Mishima, Koichi Kikuchi, Hideki Ota, Yasutoshi Akiyama, Takehiro Suzuki, Kazumasa Seiji, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito

JOURNAL OF CLINICAL HYPERTENSION　18　(4)　364-365　2016年4月

DOI： 10.1111/jch.12675 　

ISSN：1524-6175

eISSN：1751-7176
Association between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy: Prospective study using I-123 BMIPP SPECT/CT 査読有り

Kentaro Takanami, Akira Arai, Rei Umezawa, Takashi Takeuchi, Noriynki Kadoya, Yasuyuki Taki, Keiichi Jingu, Kei Takase

RADIOTHERAPY AND ONCOLOGY　119　(1)　77-83　2016年4月

DOI： 10.1016/j.radonc.2016.01.024 　

ISSN：0167-8140
Dynamic multidetector CT and non-contrast-enhanced MR for right adrenal vein imaging: comparison with catheter venography in adrenal venous sampling 査読有り

Hideki Ota, Kazumasa Seiji, Masahiro Kawabata, Nozomi Satani, Kei Omata, Yoshikiyo Ono, Yoshitsugu Iwakura, Ryo Morimoto, Tomonori Matsuura, Masataka Kudo, Junya Tominaga, Fumitoshi Satoh, Sadayoshi Ito, Kei Takase

EUROPEAN RADIOLOGY　26　(3)　622-630　2016年3月

DOI： 10.1007/s00330-015-3872-3 　

ISSN：0938-7994

eISSN：1432-1084
Impact of Small Renal Ischemia in Hypertension Development: Renovascular Hypertension Caused by Small Branch Artery Stenosis 査読有り

Eikan Mishima, Junichiro Hashimoto, Yasutoshi Akiyama, Hisato Shima, Kazumasa Seiji, Kei Takase, Takaaki Abe, Sadayoshi Ito

JOURNAL OF CLINICAL HYPERTENSION　18　(3)　248-249　2016年3月

DOI： 10.1111/jch.12661 　

ISSN：1524-6175

eISSN：1751-7176
Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism 査読有り

Yoshitsugu Iwakura, Sadayoshi Ito, Ryo Morimoto, Masataka Kudo, Yoshikiyo Ono, Masahiro Nezu, Kei Takase, Kazumasa Seiji, Shigeto Ishidoya, Yoichi Arai, Yasuharu Funamizu, Takashi Miki, Yasuhiro Nakamura, Hironobu Sasano, Fumitoshi Satoh

HYPERTENSION　67　(3)　654-660　2016年3月

DOI： 10.1161/HYPERTENSIONAHA.115.05924 　

ISSN：0194-911X

eISSN：1524-4563
Lipomatous hypertrophy of the interatrial septumが疑われた症例

前川由依, 外山由貴, 荒井晃, 高浪健太郎, 高瀬圭, 瀧靖之

核医学　53　(1)　509-509　2016年2月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
弓部置換術後遠隔期リークとの鑑別を要した人工血管周囲血腫の1例

大村健介, 大田英揮, 高瀬圭, 松浦智徳, 常陸真, 冨永循哉, 清治和将, 田村亮

Japanese Journal of Radiology　34　(Suppl.)　14-14　2016年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN：1867-1071

eISSN：1867-108X
嗄声を主訴に多発リンパ節転移が発見され、FDG-PET/CTにて指摘した前立腺癌の1例

寺尾千秋, 下村英雄, 戸恒智子, 舘脇康子, 阿部十也, 武藤達士, 瀧靖之, 荒井晃, 高浪健太郎, 高瀬圭

核医学　53　(1)　512-512　2016年2月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
著明な腹水貯留を呈した原発不明癌に対してFDG-PET/CTを施行した一例

小林洋樹, 下村英雄, 舘脇康子, 阿部十也, 武藤達士, 瀧靖之, 荒井晃, 高浪健太郎, 高瀬圭

核医学　53　(1)　512-512　2016年2月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
タルクによる胸膜癒着術を施行した1症例におけるFDG-PET所見

榊原宏幸, 荒井晃, 高浪健太郎, 高瀬圭, 戸恒智子, 下村英雄, 舘脇康子, 武藤達士, 瀧靖之, 渡辺みか, 井上健太郎

核医学　53　(1)　568-568　2016年2月
出版者・発行元： (一社)日本核医学会
ISSN：0022-7854

eISSN：2189-9932
Erratum to: Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer [Eur Radiol, DOI 10.1007/s00330-015-3847-4] 査読有り

Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

European Radiology　26　(2)　340-341　2016年2月1日
出版者・発行元： Springer Verlag
DOI： 10.1007/s00330-015-3888-8 　

ISSN：1432-1084 0938-7994

eISSN：1432-1084
Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer 査読有り

Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

EUROPEAN RADIOLOGY　26　(2)　331-339　2016年2月

DOI： 10.1007/s00330-015-3847-4 　

ISSN：0938-7994

eISSN：1432-1084
Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer (vol 26, pg 331, 2016) 査読有り

Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

EUROPEAN RADIOLOGY　26　(2)　340-341　2016年2月

DOI： 10.1007/s00330-015-3888-8 　

ISSN：0938-7994

eISSN：1432-1084
Morphology evaluation of nonmass enhancement on breast MRI: Effect of a three-step interpretation model for readers' performances and biopsy recommendations 査読有り

Akiko Shimauchi, Hideki Ota, Youichi Machida, Tamiko Yoshida, Nozomi Satani, Naoko Mori, Kei Takase, Mitsuhiro Tozaki

EUROPEAN JOURNAL OF RADIOLOGY　85　(2)　480-488　2016年2月

DOI： 10.1016/j.ejrad.2015.11.043 　

ISSN：0720-048X

eISSN：1872-7727
Canadian CT head rule and New Orleans Criteria in mild traumatic brain injury: comparison at a tertiary referral hospital in Japan 査読有り

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Kei Takase, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

SPRINGERPLUS　5　176　2016年2月

DOI： 10.1186/s40064-016-1781-9 　

ISSN：2193-1801
Intra-adrenal Aldosterone Secretion: Segmental Adrenal Venous Sampling for Localization 査読有り

Nozomi Satani, Hideki Ota, Kazumasa Seiji, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Masahiro Nezu, Kei Omata, Sadayoshi Ito, Fumitoshi Satoh, Kei Takase

RADIOLOGY　278　(1)　265-274　2016年1月

DOI： 10.1148/radiol.2015142159 　

ISSN：0033-8419
Pulmonary Arterial Hypertension Associated with Congenital Portosystemic Shunts Treated with Transcatheter Embolization and Pulmonary Vasodilators 査読有り

Haruka Sato, Masanobu Miura, Nobuhiro Yaoita, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Kimio Satoh, Hideki Ota, Kei Takase, Koichiro Sugimura, Hiroaki Shimokawa

INTERNAL MEDICINE　55　(17)　2429-2432　2016年

DOI： 10.2169/internalmedicine.55.6557 　

ISSN：0918-2918

eISSN：1349-7235
Utility of diffusion tensor imaging parameters for diagnosis of hemimegalencephaly 査読有り

Tomomi Oikawa, Yasuko Tatewaki, Takaki Murata, Yumiko Kato, Shunji Mugikura, Kei Takase, Shoki Takahashi

Neuroradiology Journal　28　(6)　628-633　2015年12月1日
出版者・発行元： SAGE Publications Inc.
DOI： 10.1177/1971400915609334 　

ISSN：1971-4009
Identifying the Adamkiewicz artery using 3-T time-resolved magnetic resonance angiography: its role in addition to multidetector computed tomography angiography 査読有り

Hidenobu Takagi, Hideki Ota, Yutaka Natsuaki, Yoshiaki Komori, Koki Ito, Yoshikatsu Saiki, Kei Takase

JAPANESE JOURNAL OF RADIOLOGY　33　(12)　749-756　2015年12月

DOI： 10.1007/s11604-015-0490-6 　

ISSN：1867-1071

eISSN：1867-108X
二管球CTによる肺灌流画像を用いた慢性血栓塞栓性肺高血圧症の重症度評価

高木英誠, 大田英揮, 佐藤遙, 三浦正暢, 青木竜男, 建部俊介, 杉村宏一郎, 冨永循哉, 下川宏明, 高瀬圭

日独医報　60　(2)　238-238　2015年11月
出版者・発行元：バイエル薬品(株)
ISSN：0912-0351
A comparative study of the extent of cerebral microvascular injury following whole-brain irradiation versus reduced-field irradiation in long-term survivors of intracranial germ cell tumors 査読有り

Li Li, Shunji Mugikura, Toshihiro Kumabe, Takaki Murata, Etsuro Mori, Kei Takase, Keiichi Jingu, Shoki Takahashi

RADIOTHERAPY AND ONCOLOGY　117　(2)　302-307　2015年11月

DOI： 10.1016/j.radonc.2015.09.017 　

ISSN：0167-8140
A Case of Apparent Lung Adenocarcinoma Size Reduction During Steroid Therapy 査読有り

Yoshinao Sato, Katsunori Oikado, Junya Tominaga, Akira Sakurada, Ryoko Saito, Kei Takase

JOURNAL OF THORACIC IMAGING　30　(6)　W80-W81　2015年11月

DOI： 10.1097/RTI.0000000000000178 　

ISSN：0883-5993

eISSN：1536-0237
Is there a role for segmental adrenal venous sampling and adrenal sparing surgery in patients with primary aldosteronism? 査読有り

Fumitoshi Satoh, Ryo Morimoto, Kazumasa Seiji, Nozomi Satani, Hideki Ota, Yoshitsugu Iwakura, Yoshikiyo Ono, Masataka Kudo, Masahiro Nezu, Kei Omata, Yuta Tezuka, Yoshihide Kawasaki, Shigeto Ishidoya, Yoichi Arai, Kei Takase, Yasuhiro Nakamura, Keely McNamara, Hironobu Sasano, Sadayoshi Ito

EUROPEAN JOURNAL OF ENDOCRINOLOGY　173　(4)　465-477　2015年10月

DOI： 10.1530/EJE-14-1161 　

ISSN：0804-4643

eISSN：1479-683X
Posterior reversible encephalopathy syndrome treated with renin-angiotensin system blockade 査読有り

Eikan Mishima, Junichiro Hashimoto, Yasutoshi Akiyama, Kazumasa Seiji, Kei Takase, Takaaki Abe, Sadayoshi Ito

JOURNAL OF THE NEUROLOGICAL SCIENCES　355　(1-2)　219-221　2015年8月

DOI： 10.1016/j.jns.2015.06.007 　

ISSN：0022-510X

eISSN：1878-5883
Spontaneous rupture of a renal angiomyolipoma at 25 weeks of pregnancy treated with transarterial embolization: A case report and review of the literature 査読有り

Shingo Myoen, Koji Mitsuzuka, Hideo Saito, Hideki Ota, Kei Takase, Yoichi Arai

INTERNATIONAL JOURNAL OF UROLOGY　22　(7)　710-712　2015年7月

DOI： 10.1111/iju.12775 　

ISSN：0919-8172

eISSN：1442-2042
Measurement of Peripheral Plasma 18-Oxocortisol Can Discriminate Unilateral Adenoma From Bilateral Diseases in Patients With Primary Aldosteronism 査読有り

Fumitoshi Satoh, Ryo Morimoto, Yoshikiyo Ono, Yoshitsugu Iwakura, Kei Omata, Masataka Kudo, Kei Takase, Kazumasa Seiji, Hidehiko Sasamoto, Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita, Celso E. Gomez-Sanchez, William E. Rainey, Yoichi Arai, Hironobu Sasano, Yasuhiro Nakamura, Sadayoshi Ito

HYPERTENSION　65　(5)　1096-1102　2015年5月

DOI： 10.1161/HYPERTENSIONAHA.114.04453 　

ISSN：0194-911X

eISSN：1524-4563
Assessment of myocardial metabolic disorder associated with mediastinal radiotherapy for esophageal cancer -a pilot study- 査読有り

Rei Umezawa, Kentaro Takanami, Noriyuki Kadoya, Yujiro Nakajima, Masahide Saito, Hideki Ota, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Takaya Yamamoto, Yojiro Ishikawa, Ken Takeda, Yasuyuki Taki, Kei Takase, Keiichi Jingu

RADIATION ONCOLOGY　10　96　2015年4月

DOI： 10.1186/s13014-015-0410-z 　

ISSN：1748-717X
Intraventricular Hemorrhage on Initial Computed Tomography as Marker of Diffuse Axonal Injury after Traumatic Brain Injury 査読有り

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Li Li, Kei Takase, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

JOURNAL OF NEUROTRAUMA　32　(5)　359-365　2015年3月

DOI： 10.1089/neu.2014.3453 　

ISSN：0897-7151

eISSN：1557-9042
Luminal-Type Breast Cancer: Correlation of Apparent Diffusion Coefficients with the Ki-67 Labeling Index 査読有り

Naoko Mori, Hideki Ota, Shunji Mugikura, Chiaki Takasawa, Takanori Ishida, Gou Watanabe, Hiroshi Tada, Mika Watanabe, Kei Takase, Shoki Takahashi

RADIOLOGY　274　(1)　66-73　2015年1月

DOI： 10.1148/radiol.14140283 　

ISSN：0033-8419
Regional Reliability of Quantitative Signal Targeting with Alternating Radiofrequency (STAR) Labeling of Arterial Regions (QUASAR) 査読有り

Yasuko Tatewaki, Shuichi Higano, Yasuyuki Taki, Benjamin Thyreau, Takaki Murata, Shunji Mugikura, Daisuke Ito, Kei Takase, Shoki Takahashi

JOURNAL OF NEUROIMAGING　24　(6)　554-561　2014年11月

DOI： 10.1111/jon.12076 　

ISSN：1051-2284

eISSN：1552-6569
Different expression of 11β-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas. 査読有り

Ono Y, Nakamura Y, Maekawa T, Felizola SJ, Morimoto R, Iwakura Y, Kudo M, Seiji K, Takase K, Arai Y, Gomez-Sanchez CE, Ito S, Sasano H, Satoh F

Hypertension (Dallas, Tex. : 1979)　64　(2)　438-+　2014年8月

DOI： 10.1161/HYPERTENSIONAHA.113.02944 　

ISSN：0194-911X

eISSN：1524-4563
Predictors of Decreasing Glomerular Filtration Rate and Prevalence of Chronic Kidney Disease After Treatment of Primary Aldosteronism: Renal Outcome of 213 Cases 査読有り

Yoshitsugu Iwakura, Ryo Morimoto, Masataka Kudo, Yoshikiyo Ono, Kei Takase, Kazumasa Seiji, Yoichi Arai, Yasuhiro Nakamura, Hironobu Sasano, Sadayoshi Ito, Fumitoshi Satoh

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　99　(5)　1593-1598　2014年5月

DOI： 10.1210/jc.2013-2180 　

ISSN：0021-972X

eISSN：1945-7197
Early CT Findings to Predict Early Death in Patients with Traumatic Brain Injury: Marshall and Rotterdam CT Scoring Systems Compared in the Major Academic Tertiary Care Hospital in Northeastern Japan 査読有り

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Kiyoshi Ishii, Li Li, Kei Takase, Shigeki Kushimoto, Shoki Takahashi

ACADEMIC RADIOLOGY　21　(5)　605-611　2014年5月

DOI： 10.1016/j.acra.2014.01.017 　

ISSN：1076-6332

eISSN：1878-4046
PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues 査読有り

Saulo J. A. Felizola, Yasuhiro Nakamura, Yoshikiyo Ono, Kanako Kitamura, Kumi Kikuchi, Yoshiaki Onodera, Kazue Ise, Kei Takase, Akira Sugawara, Namita Hattangady, William E. Rainey, Fumitoshi Satoh, Hironobu Sasano

JOURNAL OF MOLECULAR ENDOCRINOLOGY　52　(2)　159-167　2014年4月

DOI： 10.1530/JME-13-0248 　

ISSN：0952-5041
Characterization of lipid-rich adrenal tumors by FDG PET/CT: Are they hormone-secreting or not? 査読有り

Kentaro Takanami, Tomohiro Kaneta, Ryo Morimoto, Fumitoshi Satoh, Yasuhiro Nakamura, Kei Takase, Shoki Takahashi

ANNALS OF NUCLEAR MEDICINE　28　(2)　145-153　2014年2月

DOI： 10.1007/s12149-013-0793-6 　

ISSN：0914-7187

eISSN：1864-6433
Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism. 査読有り

Doi M, Satoh F, Maekawa T, Nakamura Y, Fustin JM, Tainaka M, Hotta Y, Takahashi Y, Morimoto R, Takase K, Ito S, Sasano H, Okamura H

The Journal of clinical endocrinology and metabolism　99　(2)　E257-E262　2014年2月

DOI： 10.1210/jc.2013-3279 　

ISSN：0021-972X

eISSN：1945-7197
Evaluation of Spinal cord ischemia with a retrievable stent graft is useful for determining the type of repair for a case of patch aneurysm 査読有り

Junetsu Akasaka, Kei Takase, Koichi Tabayashi

Annals of Vascular Surgery　28　(5)　1313-e3　2014年
出版者・発行元： Elsevier Inc.
DOI： 10.1016/j.avsg.2013.08.024 　

ISSN：1615-5947 0890-5096
Detection of invasive components in cases of breast ductal carcinoma in situ on biopsy by using apparent diffusion coefficient MR parameters 査読有り

Naoko Mori, Hideki Ota, Shunji Mugikura, Chiaki Takasawa, Junya Tominaga, Takanori Ishida, Mika Watanabe, Kei Takase, Shoki Takahashi

European Radiology　23　(10)　2705-2712　2013年10月

DOI： 10.1007/s00330-013-2902-2 　

ISSN：0938-7994 1432-1084

eISSN：1432-1084
Evaluation of radiation-induced myocardial damage using iodine-123 β-methyl-iodophenyl pentadecanoic acid scintigraphy. 査読有り

Umezawa R, Takase K, Jingu K, Takanami K, Ota H, Kaneta T, Takeda K, Matsushita H, Ariga H, Takahashi S, Yamada S

Journal of radiation research　54　(5)　880-889　2013年9月

DOI： 10.1093/jrr/rrt011 　

ISSN：0449-3060
Cardiac output obtained from test bolus injections as a factor in contrast injection rate revision of following coronary CT angiography 査読有り

Masahiko Konno, Yoshiyuki Hosokai, Akihito Usui, Mitsuya Abe, Toshiki Tateishi, Yusuke Kawasumi, Masashi Tsuda, Hideki Ota, Kei Takase, Haruo Saito

ACTA RADIOLOGICA　53　(10)　1107-1111　2012年12月

DOI： 10.1258/ar.2012.120276 　

ISSN：0284-1851
Properties of N-Butyl Cyanoacrylate-iodized Oil Mixtures for Arterial Embolization: In Vitro and In Vivo Experiments 査読有り

Chiaki Takasawa, Kazumasa Seiji, Kenichi Matsunaga, Toshio Matsuhashi, Makoto Ohta, Shuya Shida, Kei Takase, Shoki Takahashi

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　23　(9)　1215-1221　2012年9月

DOI： 10.1016/j.jvir.2012.06.022 　

ISSN：1051-0443
Endovascular aneurysmal models at the external iliac artery of dogs 査読有り

Kenichi Matsunaga, Chiaki Takasawa, Kazumasa Seiji, Kei Takase, Shoki Takahashi, Toshio Matsuhashi, Yasuhiro Nakamura, Fumiyoshi Fujisihima

JOURNAL OF VASCULAR SURGERY　55　(6)　1742-1748　2012年6月

DOI： 10.1016/j.jvs.2011.11.056 　

ISSN：0741-5214
Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation 査読有り

Kentaro Takanami, Takayuki Yamada, Masashi Tsuda, Kei Takase, Kazuyuki Ishida, Yasuhiro Nakamura, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno, Shoki Takahashi

ABDOMINAL IMAGING　36　(4)　447-456　2011年8月

DOI： 10.1007/s00261-010-9649-x 　

ISSN：0942-8925
Additional value of FDG PET/CT to contrast-enhanced CT in the differentiation between benign and malignant intraductal papillary mucinous neoplasms of the pancreas with mural nodules 査読有り

Kentaro Takanami, Tomomichi Hiraide, Masashi Tsuda, Yasuhiro Nakamura, Tomohiro Kaneta, Kei Takase, Hiroshi Fukuda, Shoki Takahashi

ANNALS OF NUCLEAR MEDICINE　25　(7)　501-510　2011年8月

DOI： 10.1007/s12149-011-0494-y 　

ISSN：0914-7187

eISSN：1864-6433
18-Oxocortisol Measurement in Adrenal Vein Sampling as a Biomarker for Subclassifying Primary Aldosteronism 査読有り

Yasuhiro Nakamura, Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Kei Takase, Celso E. Gomez-Sanchez, Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita, William E. Rainey, Hironobu Sasano, Sadayoshi Ito

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　96　(8)　E1272-E1278　2011年8月

DOI： 10.1210/jc.2010-2785 　

ISSN：0021-972X
High-resolution magnetic resonance imaging of rotator cuff tears using a microscopy coil: noninvasive detection without intraarticular contrast material 査読有り

Shin Hitachi, Kei Takase, Minoru Tanaka, Yuichi Tojo, Shiro Tabata, Kazuhiro Majima, Shuichi Higano, Shoki Takahashi

JAPANESE JOURNAL OF RADIOLOGY　29　(7)　466-474　2011年8月

DOI： 10.1007/s11604-011-0583-9 　

ISSN：1867-1071
Primary aldosteronism A Japanese perspective 査読有り

Fumitoshi Satoh, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Masataka Kudo, Kei Takase, Sadayoshi Ito

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS　12　(1)　11-14　2011年3月

DOI： 10.1007/s11154-011-9161-9 　

ISSN：1389-9155
The Fatal Risk in Hepatic Artery Embolization for Hemostasis after Pancreatic and Hepatic Surgery: Importance of Collateral Arterial Pathways 査読有り

Akihiro Sato, Takayuki Yamada, Kei Takase, Toshio Matsuhashi, Shuichi Higano, Tomohiro Kaneda, Shinichi Egawa, Kazunori Takeda, Tadashi Ishibashi, Shoki Takahashi

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　22　(3)　287-293　2011年3月

DOI： 10.1016/j.jvir.2010.11.023 　

ISSN：1051-0443
Thoracic Duct Visualization: Combined Use of Multidetector-Row Computed Tomography and Magnetic Resonance Imaging 査読有り

Takumi Kato, Kei Takase, Hirofumi Ichikawa, Susumu Satomi, Shoki Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　35　(2)　260-265　2011年3月

DOI： 10.1097/RCT.0b013e31820a0b0e 　

ISSN：0363-8715
MDCT of the artery of Adamkiewicz 査読有り

Kei Takase, Shoki Takahashi

Neurovascular Imaging: MRI and Microangiography　451-463　2011年
出版者・発行元： Springer London
DOI： 10.1007/978-1-84882-134-7_17 　
Simultaneous Evaluation of the Whole Aorta and Artery of Adamkiewicz by MDCT. 査読有り

Takase K

Annals of vascular diseases　4　(4)　286-292　2011年

DOI： 10.3400/avd.di.11.00725 　

ISSN：1881-641X
Demonstration of the Anatomy of the Esophageal Artery Using Multidetector-Row Helical Computed Tomography 査読有り

Takumi Kato, Kei Takase, Hirofumi Ichikawa, Susumu Satomi, Shoki Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　34　(6)　939-944　2010年11月

DOI： 10.1097/RCT.0b013e3181ed9cf4 　

ISSN：0363-8715
Bronchial Artery Anatomy: Preoperative 3D Simulation with Multidetector CT 査読有り

Yoshiaki Morita, Kei Takase, Hirofumi Ichikawa, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Shoki Takahashi

RADIOLOGY　255　(3)　934-943　2010年6月

DOI： 10.1148/radiol.10081220 　

ISSN：0033-8419
Patient-specific morphological and blood flow analysis of pulmonary artery in the case of severe deformations of the lung due to pneumothorax 査読有り

Jean-Joseph Christophe, Takuji Ishikawa, Noriaki Matsuki, Yohsuke Imai, Kei Takase, Marc Thiriet, Takami Yamaguchi

Journal of Biomechanical Science and Engineering　5　(5)　485-498　2010年

DOI： 10.1299/jbse.5.485 　

ISSN：1880-9863
Treatment of in-stent restenosis with beraprost sodium: An experimental study of short- and intermediate-term effects in dogs 査読有り

Kazumasa Seiji, Masashi Tsuda, Toshio Matsuhashi, Kei Takase, Hideo Miyachi, Takayuki Yamada, Tadashi Ishibashi, Shuichi Higano, Shoki Takahashi

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY　36　(12)　1164-1169　2009年12月

DOI： 10.1111/j.1440-1681.2009.05209.x 　

ISSN：0305-1870
Differentiation of Femoral and Inguinal Hernias on the Basis of Anteroposterior Relationship to the Inguinal Ligament on Multidimensional Computed Tomography 査読有り

Masahiro Kitami, Kei Takase, Masahiro Tsuboi, Yuya Rikimaru, Takashi Hakamatsuka, Takayuki Yamada, Shoki Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　33　(5)　678-681　2009年9月

DOI： 10.1097/RCT.0b013e3181977a0a 　

ISSN：0363-8715
Tagged cine magnetic resonance imaging with a finite element model can predict the severity of retrosternal adhesions prior to redo cardiac surgery 査読有り

Ichiro Yoshioka, Yoshikatsu Saiki, Azusa Ichinose, Kei Takase, Shoki Takahashi, Toshiro Ohashi, Masaaki Sato, Koichi Tabayashi

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY　137　(4)　957-962　2009年4月

DOI： 10.1016/j.jtcvs.2008.10.036 　

ISSN：0022-5223
Correct Diagnosis of Vascular Encasement and Longitudinal Extension of Hilar Cholangiocarcinoma by Four-Channel Multidetector-Row Computed Tomography 査読有り

Tadayuki Okumoto, Akihiro Sato, Takayuki Yamada, Kei Takase, Toshio Matsuhashi, Masashi Tsuda, Kazumasa Seiji, Tadashi Ishibashi, Shuichi Higano, Yu Katayose, Michiaki Unno, Shoki Takahashi

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　217　(1)　1-8　2009年1月

DOI： 10.1620/tjem.217.1 　

ISSN：0040-8727

eISSN：1349-3329
[Use of the keyhole technique for 3.0T MRI dynamic imaging]. 査読有り

Itou D, Nagasaka T, Yanagawa I, Yoshida S, Takase K

Nihon Hoshasen Gijutsu Gakkai zasshi　64　(12)　1562-1567　2008年12月
出版者・発行元：公益社団法人日本放射線技術学会
DOI： 10.6009/jjrt.64.1562 　

ISSN：0369-4305

詳細を見る詳細を閉じる

We studied the feasibility of high spatial and temporally resolved imaging by a combination of keyhole imaging, which is a fast imaging method, and a 3.0T MRI system which inherently has a high signal-to-noise ratio (SNR). In keyhole imaging, full k-space reference data are collected, followed by repeated dynamic acquisition of the central low-frequency data alone, and this makes dynamic acquisition faster. The purpose of our article is to describe the effects of the reference data on the reconstructed dynamic images with the assumption of vessel visualization. For efficient use of keyhole imaging, it is important to optimize the keyhole percentage and timing of reference data acquisition for the object of interest.
Differentiation of Pathologic Subtypes of Papillary Renal Cell Carcinoma on CT 査読有り

Takayuki Yamada, Mareyuki Endo, Masahiro Tsuboi, Toshio Matsuhashi, Kei Takase, Shuichi Higano, Shoki Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　191　(5)　1559-1563　2008年11月

DOI： 10.2214/AJR.07.3181 　

ISSN：0361-803X
High-resolution monochrome liquid crystal display versus efficient household colour liquid crystal display: comparison of their diagnostic performance with unenhanced CT images in focal liver lesions 査読有り

Yusuke Kawasumi, Takayuki Yamada, Hideki Ota, Masahiro Tsuboi, Kei Takase, Akihiro Sato, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

EUROPEAN RADIOLOGY　18　(10)　2148-2154　2008年10月

DOI： 10.1007/s00330-008-1008-8 　

ISSN：0938-7994
MRI of cardiac sarcoidosis: Basal and subepicardial localization of myocardial lesions and their effect on left ventricular function 査読有り

Azusa Ichinose, Hiroki Otani, Minako Oikawa, Kei Takase, Haruo Saito, Hiroaki Shimokawa, Shoki Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　191　(3)　862-869　2008年9月

DOI： 10.2214/AJR.07.3089 　

ISSN：0361-803X
Radiologic anatomy of the right adrenal vein: Preliminary experience with MDCT 査読有り

Tomonori Matsuura, Kei Takase, Hideki Ota, Takayuki Yamada, Akihiro Sato, Fumitoshi Satoh, Shoki Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　191　(2)　402-408　2008年8月

DOI： 10.2214/AJR.07.3338 　

ISSN：0361-803X
Validation of the use of calibration factors between the iodine concentration and the computed tomography number measured outside the objects for estimation of iodine concentration inside the objects: phantom experiment 査読有り

Kentaro Takanami, Shuichi Higano, Kei Takase, Tomohiro Kaneta, Takayuki Yamada, Hiroki Ishiya, Issei Mori, Shoki Takahashi

RADIATION MEDICINE　26　(4)　237-243　2008年5月

DOI： 10.1007/s11604-007-0220-9 　

ISSN：1862-5274
Electrocardiographic characteristics of the variants of idiopathic left ventricular outflow tract ventricular tachyarrhythmias 査読有り

Koji Kumagai, Koji Fukuda, Yuji Wakayama, Yoshinao Sugai, Masanori Hirose, Nobuhiro Yamaguchi, Kei Takase, Yasuteru Yamauchi, Atsushi Takahashi, Kazutaka Aonuma, Hiroaki Shimokawa

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY　19　(5)　495-501　2008年5月

DOI： 10.1111/j.1540-8167.2007.01085.x 　

ISSN：1045-3873
Validation of the use of calibration factors between the iodine concentration and the computed tomography number measured outside the objects for estimation of iodine concentration inside the objects: Phantom experiment 査読有り

Kentaro Takanami, Shuichi Higano, Kei Takase, Tomohiro Kaneta, Takayuki Yamada, Hiroki Ishiya, Issei Mori, Shoki Takahashi

Radiation Medicine - Medical Imaging and Radiation Oncology　26　(4)　237-243　2008年5月

DOI： 10.1007/s11604-007-0220-9 　

ISSN：0288-2043 1862-5274

eISSN：1862-5274
Perforated and nonperforated appendicitis: Defect in enhancing appendiceal wall - Depiction with multi-detector row CT 査読有り

Masahiro Tsuboi, Kei Takase, Iwao Kaneda, Tadashi Ishibashi, Takayuki Yamada, Masahiro Kitami, Shuichi Higano, Shoki Takahashi

RADIOLOGY　246　(1)　142-147　2008年1月

DOI： 10.1148/radiol.2461051760 　

ISSN：0033-8419
Virtual CT thoracoscopy: preoperative simulation for thoracoscopic surgery of esophageal cancer 査読有り

Yoshiaki Morita, Kei Takase, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Shoki Takahashi, Hirofumi Ichikawa

ABDOMINAL IMAGING　32　(6)　679-687　2007年11月

DOI： 10.1007/s00261-006-9165-1 　

ISSN：0942-8925
Localization of aldosterone-producing adrenocortical adenomas: significance of adrenal venous sampling. 査読有り

Satoh F, Abe T, Tanemoto M, Nakamura M, Abe M, Uruno A, Morimoto R, Sato A, Takase K, Ishidoya S, Arai Y, Suzuki T, Sasano H, Ishibashi T, Ito S

Hypertension research : official journal of the Japanese Society of Hypertension　30　(11)　1083-1095　2007年11月

DOI： 10.1291/hypres.30.1083 　

ISSN：0916-9636
Dilation of renal artery stenosis after administration of losartan. 査読有り

Tanemoto M, Takase K, Yamada T, Satoh A, Abe T, Ito S

Hypertension research : official journal of the Japanese Society of Hypertension　30　(10)　999-1002　2007年10月

DOI： 10.1291/hypres.30.999 　

ISSN：0916-9636
Primary aldosteronism: a pictorial essay 査読有り

Tadashi Ishibashi, Fumitoshi Satoh, Takayuki Yamada, Akihiro Sato, Toshio Matsuhashi, Kei Takase

ABDOMINAL IMAGING　32　(4)　504-514　2007年8月

DOI： 10.1007/s00261-006-9151-7 　

ISSN：0942-8925
[Cardiac CT and MRI]. 査読有り

Ichinose A, Takase K, Takahashi S, Kagaya Y, Shimokawa H

Nihon rinsho. Japanese journal of clinical medicine　65 Suppl 4　406-411　2007年4月

ISSN：0047-1852
Peripheral Pulmonary Artery Aneurysms in Patients with Pulmonary Artery Hypertension 査読有り

Masahito Sakuma, Jun Demachi, Jun Suzuki, Jun Nawata, Tohru Takahashi, Koichiro Sugimura, Minako Oikawa, Kei Takase, Kenji Hoshino, Shinko Souma, Kunio Shirato

INTERNAL MEDICINE　46　(13)　979-984　2007年

DOI： 10.2169/internalmedicine.46.6462 　

ISSN：0918-2918
Preoperative MDCT evaluation of the artery of Adamkiewicz and its origin. 査読有り

Takase K, Akasaka J, Sawamura Y, Ota H, Sato A, Yamada T, Higano S, Igarashi K, Chiba Y, Takahashi S

Journal of computer assisted tomography　30　(5)　716-722　2006年9月

DOI： 10.1097/01.rct.0000228150.35410.45 　

ISSN：0363-8715
Comparison of MDCT and MRI for evaluating the intraductal component of breast cancer 査読有り

Akiko Shimauchi, Takayuki Yamada, Akihiro Sato, Kei Takase, Shin Usami, Takanori Ishida, Takuya Moriya, Shoki Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　187　(2)　322-329　2006年8月

DOI： 10.2214/AJR.05.0876 　

ISSN：0361-803X
Diagnosis of aortic diseases using multidetector computed tomography 査読有り

Kei Takase, Hideki Ota, Hiroya Rikimaru, Akihiro Sato, Takayuki Yamada, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

Radiation Medicine - Medical Imaging and Radiation Oncology　24　(5)　405-414　2006年6月

DOI： 10.1007/s11604-006-0046-x 　

ISSN：0288-2043
Assessing the extent of breast cancer using multidetector row helical computed tomography 査読有り

K Takase, A Furuta, N Harada, T Takahashi, K Igarashi, Y Chiba, K Haga, S Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　30　(3)　479-485　2006年5月

DOI： 10.1097/00004728-200605000-00021 　

ISSN：0363-8715
Atlantoaxial osteoarthritis in rheumatoid arthritis: FDG PET/CT findings. 査読有り

Kaneta T, Hakamatsuka T, Yamada T, Takase K, Sato A, Higano S, Ito H, Fukuda H, Takahashi S, Yamada S

Clinical nuclear medicine　31　(4)　209　2006年4月

DOI： 10.1097/01.rlu.0000204124.79497.bb 　

ISSN：0363-9762
Evaluation of the relationship between physiological FDG uptake in the heart and age, blood glucose level, fasting period, and hospitalization 査読有り

T Kaneta, T Hakamatsuka, K Takanami, T Yamada, K Takase, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

ANNALS OF NUCLEAR MEDICINE　20　(3)　203-208　2006年4月

DOI： 10.1007/bf03027431 　

ISSN：0914-7187
FDG PET in solitary metastastic/secondary tumor of the kidney: A report of three cases and a review of the relevant literature

T Kaneta, T Hakamatsuka, T Yamada, K Takasa, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

ANNALS OF NUCLEAR MEDICINE　20　(1)　79-82　2006年1月

DOI： 10.1007/BF02985596 　

ISSN：0914-7187
Types and frequencies of biliary tract variations associated with a major portal venous anomaly: Analysis with multi-detector row CT cholangiography 査読有り

M Kitami, K Takase, G Murakami, S Ko, M Tsuboi, H Saito, S Higano, Y Nakajima, S Takahashi

RADIOLOGY　238　(1)　156-166　2006年1月

DOI： 10.1148/radiol.2381041783 　

ISSN：0033-8419
FDG PET in solitary metastastic/secondary tumor of the kidney: A report of three cases and a review of the relevant literature 査読有り

T Kaneta, T Hakamatsuka, T Yamada, K Takasa, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

ANNALS OF NUCLEAR MEDICINE　20　(1)　79-82　2006年1月

DOI： 10.1007/bf02985596 　

ISSN：0914-7187
Time-related changes in computed tomographic appearance and pathologic findings after radiofrequency ablation of the rabbit lung: Preliminary experimental study 査読有り

J Tominaga, H Miyachi, K Takase, T Matsuhashi, T Yamada, A Sato, H Saito, T Ishibashi, M Endoh, S Higano, S Takahashi

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　16　(12)　1719-1726　2005年12月

DOI： 10.1097/01.RVI.0000182507.37324.3E 　

ISSN：1051-0443
Quantitative vascular measurements in arterial occlusive disease 査読有り

Hideki Ota, Kei Takase, Hiroya Rikimaru, Masahiro Tsuboi, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

Radiographics　25　(5)　1141-1158　2005年9月

DOI： 10.1148/rg.255055014 　

ISSN：1527-1323
Quantitative vascular measurements in arterial occlusive disease. 査読有り

Ota H, Takase K, Rikimaru H, Tsuboi M, Yamada T, Sato A, Higano S, Ishibashi T, Takahashi S

Radiographics : a review publication of the Radiological Society of North America, Inc　25　(5)　1141-1158　2005年9月

DOI： 10.1148/rg.255055014 　

ISSN：0271-5333
Heterogeneity of subvesical ducts or the ducts of Luschka: A study using drip-infusion cholangiography-computed tomography in patients and cadaver specimens 査読有り

M Kitami, G Murakami, D Suzuki, K Takase, M Tsuboi, H Saito, S Takahashi

WORLD JOURNAL OF SURGERY　29　(2)　217-223　2005年2月

DOI： 10.1007/s00268-004-7652-5 　

ISSN：0364-2313
MDCT for vascular diseases; one stop shopping imaging

Kei Takase, Y. Chiba

Japanese Journal of Clinical Radiology　50　(1)　67-77　2005年

ISSN：0009-9252
Spiegel's lobe bile ducts often drain into the right hepatic duct or its branches: Study using drip-infusion cholangiography-computed tomography in 179 consecutive patients 査読有り

M Kitami, G Murakami, S Ko, K Takase, M Tuboi, H Saito, Y Nakajima, S Takahashi

WORLD JOURNAL OF SURGERY　28　(10)　1001-1006　2004年10月

DOI： 10.1007/s00268-004-7483-4 　

ISSN：0364-2313
Pseudoaneurysm of the inferior epigastric artery successfully treated by ultrasound-guided compression 査読有り

K Takase, T Kazama, K Abe, Y Chiba, H Saito, S Takahashi

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY　27　(5)　520-522　2004年9月

DOI： 10.1007/s00270-003-2767-x 　

ISSN：0174-1551
MDCT compared with digital subtraction angiography for assessment of lower extremity arterial occlusive disease: Importance of reviewing cross-sectional images 査読有り

H Ota, K Takase, K Igarashi, Y Chiba, K Haga, H Saito, S Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　182　(1)　201-209　2004年1月

DOI： 10.2214/ajr.182.1.1820201 　

ISSN：0361-803X
Another blood supply to Adamkiewicz's artery 査読有り

Junetsu Akasaka, Masahiro Sakurai, Kei Takase, Kiichiro Kumagai, Koichi Tabayashi

Japanese Journal of Thoracic and Cardiovascular Surgery　52　(9)　432-434　2004年
出版者・発行元： Japanese Association for Thoracic Surgery
DOI： 10.1007/s11748-004-0039-6 　

ISSN：1344-4964
Surgical Repair for Tracheo-Innominate Artery Fistula with a Muscle Flap 査読有り

Yoshihiro Sawamura, Kei Takase, Norio Higuchi, Sekinori Kikuchi, Takashi Ito, Koichi Tabayashi

Japanese Journal of Thoracic and Cardiovascular Surgery　51　(11)　630-633　2003年
出版者・発行元： Japanese Association for Thoracic Surgery
DOI： 10.1007/BF02736707 　

ISSN：1344-4964
急性虫垂炎の診断と治療方針決定におけるCTの有用性

工藤博典, 金田巌, 樋口則男, 古田昭彦, 石橋悟, 初貝和明, 庄子成美, 高瀬圭, 高橋徹

東北医学雑誌　114　(1)　146-146　2002年8月
出版者・発行元：東北医学会
ISSN：0040-8700
マルチスライスヘリカルCTを用いた乳癌の広がり診断

庄子成美, 金田巌, 樋口則男, 古田昭彦, 石橋悟, 初貝和明, 中川有, 工藤博典, 高瀬圭, 高橋徹

東北医学雑誌　114　(1)　155-155　2002年8月
出版者・発行元：東北医学会
ISSN：0040-8700
虫垂炎診断及び手術適応決定におけるマルチスライスヘリカルCTの有用性

工藤博典, 金田巖, 樋口則男, 古田昭彦, 石橋悟, 初貝和明, 庄子成美, 高瀬圭, 高橋徹

日本消化器外科学会雑誌　35　(7)　1142-1142　2002年7月
出版者・発行元： (一社)日本消化器外科学会
ISSN：0386-9768

eISSN：1348-9372
Three-dimensional imaging of coronary artery bypass grafts. 査読有り

Sawamura Y, Takase K, Saito H, Kikuchi S, Ito T

The Annals of thoracic surgery　73　(5)　1655　2002年5月

DOI： 10.1016/s0003-4975(01)02741-2 　

ISSN：0003-4975
Demonstration of the artery of Adamkiewicz at multi-detector row helical CT 査読有り

K Takase, Y Sawamura, K Igarashi, Y Chiba, K Haba, H Saito, S Takahashi

RADIOLOGY　223　(1)　39-45　2002年4月

DOI： 10.1148/radiol.2231010513 　

ISSN：0033-8419
Pericardiectomy for post-coronary artery bypass grafting constrictive pericarditis; strategy for safe and complete pericardiectomy

T. Shibuya, M. Ohmi, S. Kawamoto, M. Shimizu, M. Ohuchi, Y. Sawamura, S. Kikuchi, T. Ito, K. Takase

Kyobu geka. The Japanese journal of thoracic surgery　55　1149-1152　2002年1月1日

ISSN：0021-5252
Three-dimensional imaging of coronary artery bypass grafts

Yoshihiro Sawamura, Kei Takase, Haruo Saito, Sekinori Kikuchi, Takashi Ito

Annals of Thoracic Surgery　73　(5)　1655　2002年

DOI： 10.1016/S0003-4975(01)02741-2 　

ISSN：0003-4975
Noninvasive postoperative angiography for internal mammary artery grafts

Y Sawamura, K Takase, H Saito, S Kikuchi, T Ito

CIRCULATION　104　(3)　373-374　2001年7月

DOI： 10.1161/01.CIR.104.3.373 　

ISSN：0009-7322
Obturator herniation visualized by multislice helical CT

Kei Takase, Akihiko Furuta, Hiroyoshi Akama

Journal of the American College of Surgeons　192　411　2001年3月24日

DOI： 10.1016/S1072-7515(00)00804-8 　

ISSN：1072-7515
Multislice helical computed tomography for minimally invasive cardiac surgery

Yoshihiro Sawamura, Kei Takase, Sekinori Kikuchi, Takashi Ito

Annals of Thoracic Surgery　71　(5)　1707　2001年

DOI： 10.1016/S0003-4975(00)02013-0 　

ISSN：0003-4975
Bronchial artery aneurysm treated with percutaneous transluminal coil embolization

Kei Sakuma, Kei Takase, Haruo Saito, Masayuki Zuguchi, Koichi Tabayashi

The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi　49　(5)　330-332　2001年

DOI： 10.1007/BF02913144 　

ISSN：1344-4964
A pitfall of reusing disposable apparatus for endoscopic surgery [2] (multiple letters)

Y. Sawamura, K. Takase, H. Saito, S. Kikuchi, T. Ito, A. S. Wechsler

Journal of Thoracic and Cardiovascular Surgery　120　617　2000年9月18日

ISSN：0022-5223
Relationship between the pixel value in digital subtraction angiography and iodine concentration: Study in high iodine concentration with original phantom

Koichi Chida, Sai Masahiro, Haruo Saito, Kei Takase, Masayuki Zuguchi, Masatoshi Sasaki, Tokutaro Sato

Tohoku Journal of Experimental Medicine　190　(3)　169-176　2000年
出版者・発行元： Tohoku University Medical Press
DOI： 10.1620/tjem.190.169 　

ISSN：0040-8727
Popliteal artery entrapment syndrome: Aberrant origin of gastrocnemius muscle shown by 3D CT

K Takase, S Imakita, S Kuribayashi, Y Onishi, M Takamiya

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　21　(4)　523-528　1997年7月

DOI： 10.1097/00004728-199707000-00003 　

ISSN：0363-8715

eISSN：1532-3145
Psychiatric wandering behaviour in dementia patients correlated with increased striatal dopamine D2 receptor as shown by [11C]YM-09151-2 and positron emission tomography

K. Meguro, M. Itoh, K. Yanai, K. Takase, S. Yamaguchi, T. Ido, A. Yamadori

European Journal of Neurology　4　(3)　221-226　1997年
出版者・発行元： Blackwell Publishing Ltd
DOI： 10.1111/j.1468-1331.1997.tb00338.x 　

ISSN：1351-5101
MR findings of avulsive cortical irregularity of the distal femur

Tetsuro Yamazaki, Shin Maruoka, Shoki Takahashi, Haruo Saito, Kei Takase, Mamoru Nakamura, Kiyohiko Sakamoto

Skeletal Radiology: A Journal of Radiology, Pathology and Orthopedics　24　43-46　1995年1月1日

DOI： 10.1007/BF02425946 　

ISSN：0364-2348
Renal cell carcinoma associated with chronic renal failure: Evaluation with sonographic angiography

Kei Takase, Shoki Takahashi, Satoru Tazawa, Yoshio Terasawa, Kiyohiko Sakamoto

Radiology　192　(3)　787-792　1994年
出版者・発行元： Radiological Society of North America Inc.
DOI： 10.1148/radiology.192.3.8058948 　

ISSN：0033-8419

︎全件表示 ︎最初の5件までを表示

MISC 46

右副腎皮質髄質混合腫瘍と左副腎腫瘍によるサブクリニカルクッシング症候群を合併した一例

小林雅幸, 小野美澄, 宍戸愛, 矢浦一磨, 沼畑貴生, 佐藤俊宏, 黒澤聡子, 久保晴丸, 手塚雄太, 尾股慧, 山崎有人, 高瀬圭, 伊藤明宏, 鈴木貴, 片桐秀樹

日本内分泌学会雑誌　100　(1)　341-341　2024年5月
出版者・発行元： (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
初診時に高レニン高アルドステロン血症を呈した片側性原発性アルドステロン症の一例

手塚雄太, 矢浦一磨, 久保晴丸, 尾股慧, 小野美澄, 菅原明, 高瀬圭, 伊藤明宏, 山崎有人, 鈴木貴, 片桐秀樹

日本内分泌学会雑誌　99　(5)　1501-1501　2024年4月
出版者・発行元： (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
ロボット支援下副腎手術の衆知を集める(標準化を目指して) 原発性アルドステロン症に対するロボット支援下副腎部分切除術

川崎芳英, 手塚雄太, 小野美澄, 尾股慧, 佐藤友紀, 方山博路, 佐竹洋平, 佐藤琢磨, 川守田直樹, 山下慎一, 小黒草太, 高瀬圭, 片桐秀樹, 伊藤明宏

日本内分泌外科学会雑誌　41　(Suppl.1)　S152-S152　2024年4月
出版者・発行元： (一社)日本内分泌外科学会
ISSN： 2434-6535

eISSN： 2758-8785
CT画像を用いたvViTと畳込みニューラルネットワークの腎癌組織型鑑別性能の比較

臼崎琢磨, 高木英誠, 高木英誠, 佐藤友美, 小黒草太, 高瀬圭

泌尿器画像診断・治療技術研究会プログラム・抄録集　10th　2023年
Medical students’ education and radiology

Naoko Mori, Kei Takase

Japanese Journal of Radiology　40　(11)　1210-1211　2022年11月

DOI： 10.1007/s11604-022-01310-0 　

ISSN： 1867-1071

eISSN： 1867-108X
Letter to the editor on “Second‑opinion reads in prostate MRI: added value of subspecialty interpretation and review at multidisciplinary rounds”

Naoko Mori, Shunji Mugikura, Kei Takase

Abdominal Radiology　47　(11)　3958-3960　2022年11月

DOI： 10.1007/s00261-022-03653-8 　

ISSN： 2366-004X

eISSN： 2366-0058
Letter to the editor on “The MRI estimations of placental thickness and cervical length correlate with postpartum hemorrhage (PPH) in patients with risk for placenta accreta spectrum (PAS) disorders”

Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

Placenta　128　72　2022年10月

DOI： 10.1016/j.placenta.2022.08.008 　

ISSN： 0143-4004

eISSN： 1532-3102
Diffusion kurtosis imaging: An effective method to evaluate the grade of glioma based on the assessment of histological nuclear size and entropy

Naoko Mori, Shunji Mugikura, Kei Takase

Clinical Neurology and Neurosurgery　221　2022年10月

DOI： 10.1016/j.clineuro.2022.107415 　

ISSN： 0303-8467

eISSN： 1872-6968
胸腺腫瘍のリスク予測モデリング:欠損値補完と機械学習の技術を用いたMRシークエンスの組合せの検証

SHIMIZU Hiroaki, MORI Naoko, REN Hainan, MUGIKURA Shunji, TAKASE Kei

日本医学放射線学会総会抄録集　81st　2022年

ISSN： 0048-0428
American College of Rheumatology and the European League Against Rheumatism classification criteria for IgG4-related disease: an update for radiologists

Hainan Ren, Naoko Mori, Satoko Sato, Shunji Mugikura, Atsushi Masamune, Kei Takase

Japanese Journal of Radiology　40　(9)　876-893　2022年

DOI： 10.1007/s11604-022-01282-1 　

ISSN： 1867-1071

eISSN： 1867-108X
Less contrast-enhanced areas within lymph nodes in the delayed phase of contrast-enhanced MRI: a suspicious finding for lymph node metastases

Naoko Mori, Shunji Mugikura, Kei Takase

Clinical and Experimental Metastasis　39　(5)　713-714　2022年

DOI： 10.1007/s10585-022-10161-y 　

ISSN： 0262-0898

eISSN： 1573-7276
外科におけるAI利用の現状と展開 AIによる食道癌術前リンパ節診断

高橋梢, 大村和元, 高浪健太郎, 谷山裕亮, 佐藤千晃, 高屋快, 岡本宏史, 福富俊明, 八嶋嘉之, 石田孝宣, 海野倫明, 高瀬圭, 亀井尚

日本外科学会定期学術集会抄録集　121回　NES-6　2021年4月
出版者・発行元： (一社)日本外科学会
心臓核医学による心機能解析現在の成果と将来展望(Cardiac Functional Analysis by Nuclear Cardiology: Current Achievements and Future Prospects)

木曽啓祐, 樋口慧, 大田英揮, 安田聡, 高瀬圭

日本循環器学会学術集会抄録集　85回　ME02-3　2021年3月
出版者・発行元： (一社)日本循環器学会
乳癌のリンパ節転移診断のための高解像度3D T2強調画像のテクスチャ解析

SHIMIZU Hiroaki, MORI Naoko, MUGIKURA Shunji, OGUMA Yo, SATO Satoko, TAKASE Kei

日本医学放射線学会総会抄録集　80th　2021年

ISSN： 0048-0428
当院でのリンパ漏・乳糜漏に対する超音波ガイド下リンパ管造影の検討

影山咲子, 大田英揮, 益田淳朗, 佐藤友美, 森田佳明, 高瀬圭

超音波医学　47　(Suppl.)　S461-S461　2020年11月
出版者・発行元： (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
非虚血心血管疾患の核医学イメージング循環器領域のデバイス・グラフト感染診断における核医学の有用性と限界

木曽啓祐, 立石恵実, 井元晃, 寺川裕介, 太田靖利, 西井達矢, 堀之内宏樹, 樋口慧, 村川圭三, 福田哲也, 高瀬圭

核医学　57　(Suppl.)　S101-S101　2020年10月
出版者・発行元： (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
当院でのリンパ漏・乳糜漏に対する超音波ガイド下リンパ管造影の検討

影山咲子, 大田英揮, 益田淳朗, 佐藤友美, 森田佳明, 高瀬圭

超音波医学 Supplement　47　2020年

ISSN： 1881-9311
重症大動脈弁狭窄症に対する経カテーテル弁置換術はBNPと左室肥大の軽減に相関して冠血流予備能を改善する

土屋聡, 松本泰治, 大田英揮, 菊池翼, 杉澤潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 鈴木祐輔, 高橋潤, 熊谷紀一郎, 斎木佳克, 高瀬圭, 下川宏明

日本心血管画像動態学会プログラム・抄録集　30th　2020年
乳がん患者における化学療法前後のマルチモダリティを用いた心機能評価

杉村宏一郎, 照井洋輔, 大田英揮, 多田寛, 佐藤遥, 後岡広太郎, 石田孝宣, 高瀬圭, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　13th　2020年
生体肝移植後の晩期胆道閉塞に対し超音波ガイド下に経皮的胆道空腸瘻形成を行った1例

影山咲子, 大田英揮, 鎌田裕基, 高瀬圭, 宮城重人

超音波医学 Supplement　47　2020年

ISSN： 1881-9311
Exercise Training Ameliorates Vasodilator Capacity of Coronary Microvessels in Patients With Vasospastic Angina -A New Therapeutic Approach for the Coronary Functional Disorder

Jun Sugisawa, Yasuharu Matsumoto, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Masashi Takeuchi, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Kajitani, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

CIRCULATION　140　2019年11月

ISSN： 0009-7322

eISSN： 1524-4539
コイル塞栓術後の再開通評価に対する造影MRIの有用性

鎌田裕基, 佐藤友美, 大田英揮, 清治和将, 高瀬圭

Japanese Journal of Radiology　37　(Supplement)　2019年

ISSN： 1867-1071
慢性血栓塞栓性肺高血圧症に対する4D flow MRI:肺動脈拡張術前後に於る血流動態解析

大田英揮, 孫文羽, 佐藤遥, 杉村宏一郎, 高瀬圭

日本心血管画像動態学会プログラム・抄録集　29th　2019年
超高齢者に発症した左胃大網動脈瘤破裂の1例

千葉和治, 水間正道, 林洋毅, 畠達夫, 伊関雅裕, 高舘達之, 川口桂, 大塚英郎, 森川孝則, 中川圭, 元井冬彦, 亀井尚, 内藤剛, 高瀬圭, 海野倫明

日本臨床外科学会雑誌　80　2019年

ISSN： 1345-2843
Focal Decrease in Cardiac 123I-Meta-Iodobenzylguanidine Uptake in Patients with Anderson-Fabry Disease

Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Syunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　22　(9)　S178-S178　2016年9月

ISSN： 1071-9164

eISSN： 1532-8414
Association between radiation dosimetry of the heart and the myocardial fatty acid metabolic impairment due to chemoradiation-therapy : Prospective study using I-123 BMIPP SPECT/CT

K. Takanami, R. Umezawa, N. Kadoya, A. Arai, K. Jingu, K. Takase

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　42　S284-S285　2015年10月

ISSN： 1619-7070

eISSN： 1619-7089
Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus surgery-first for resectable pancreatic carcer (Prep-02/JSAP05).

Michiaki Unno, Fuyuhiko Motoi, Tomoo Kosuge, Hideki Ueno, Hiroki Yamaue, Sohei Satoi, Masayuki Sho, Goro Honda, Ippei Matsumoto, Keita Wada, Junji Furuse, Tohru Furukawa, Kazuyuki Ishida, Kei Takase, Yutaka Matsuyama, Kei Nakagawa, Yu Katayose

JOURNAL OF CLINICAL ONCOLOGY　33　(15)　2015年5月

ISSN： 0732-183X

eISSN： 1527-7755
IN PRIMARY ALDOSTERONISM WITH BILATERAL ADRENAL ADNOMAS, LAPAROSCOPIC BILATERAL ADRENAL SURGERY COULD BE AN OPTIONAL TREATMENT UNDER SELECTIVE ADRENAL VENOUS SAMPLING

Yoshihide Kawasaki, Shigeto Ishidoya, Akihiro Ito, Yasuhiro Kaiho, Ryo Morimoto, Kei Takase, Yoichi Arai

JOURNAL OF UROLOGY　193　(4)　E81-E81　2015年4月

ISSN： 0022-5347

eISSN： 1527-3792
Measurement of Peripheral Blood 18-Oxocortisol as the Diagnostic Method of Primary Aldosteronism and Its Subtypes

Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Ken Matsuda, Kei Takase, Celso E. Gomez-Sanchez, William E. Rainey, Hironobu Sasano, Yoshihiro Nakamura, Sadayoshi Ito

HYPERTENSION　62　(3)　2013年9月

ISSN： 0194-911X

eISSN： 1524-4563
Measurement of Peripheral Blood 18-Oxo-Cortisol Levels Can Discriminate Surgically Curable Primary Aldosteronism Among Hypertensive Patients, Omitting Many Steps of Diagnostic Workup

Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Ken Matsuda, Kazumasa Seiji, Kei Takase, Hironobu Sasano, Yasuhiro Nakamura, Sadayoshi Ito

AMERICAN JOURNAL OF HYPERTENSION　25　(12)　1318-1319　2012年12月

ISSN： 0895-7061
Preliminary experience of laparoscopic simultaneous bilateral adrenalectomy for patients with aldosterone-producing adenoma

S. Ishidoya, A. Ito, Y. Kawasaki, M. Miyazato, Y. Kaiho, F. Satoh, R. Morimoto, K. Takase, Y. Arai

EUROPEAN UROLOGY SUPPLEMENTS　11　(1)　E1110-U309　2012年2月

ISSN： 1569-9056
胸部大動脈瘤術後患者に対するカンデサルタン投与による遠隔期の大動脈径変化の検討(パイロット・スタディより)

鈴木佑輔, 川本俊輔, 本吉直孝, 秋山正年, 熊谷紀一郎, 安達理, 齋藤武志, 増田信也, 渋谷拓見, 佐藤真一, 齋木佳克, 高瀬圭, 大田英揮, 辻一郎, 菅原由美

General Thoracic and Cardiovascular Surgery　59　(Supplement)　2011年

ISSN： 1863-6705
Evaluation of right adrenal vein by MDCT-for accurate localization of aldosterone hypersecretion by selective adrenal venous sampling

Kei Takase, Fumitoshi Satoh, Ryo Morimoto, Kazumasa Seiji, Masashi Tsuda, Takayuki Yamada, Sadayoshi Ito, Shoki Takahashi

ENDOCRINE JOURNAL　57　S636-S636　2010年3月

ISSN： 0918-8959
Endocrinological evaluation of successful sampling from right adrenal veins in patients with primary aldosteronism

Ryo Morimoto, Fumitoshi Satoh, Masataka Kudo, Osamu Murakami, Yoshitsugu Iwakura, Kei Takase, Tadashi Ishibashi, Shoki Takahashi, Shigeto Ishidoya, Yoichi Arai, Yasuhiro Nakamura, Takashi Suzuki, Hironobu Sasano, Sadayoshi Ito

ENDOCRINE JOURNAL　57　S627-S627　2010年3月

ISSN： 0918-8959
Recommendation of adrenal venous sampling before surgical treatments for the patients of primary aldosteronism with adrenal nodules on CT: the differential diagnosis of 329 patients with primary aldosteronism in comparison with their computed tomographic findings

Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshinori Iwakura, Osamu Murakami, Kei Takase, Shoki Takahashi, Yoichi Arai, Yoshihiro Nakamura, Takashi Suzuki, Hironobu Sasano, Sadayoshi Ito

ENDOCRINE JOURNAL　57　S552-S552　2010年3月

ISSN： 0918-8959
Renal outcome in patients with primary aldosteronism: manifestation of "masked" CKD by correction of aldosterone-induced glomerular hyperfiltration and one-year follow-up with aldosterone blockade or unilateral adrenalectomy

Yoshitsugu Iwakura, Ryo Morimoto, Masataka Kudo, Osamu Murakami, Kei Takase, Shigeto Ishidoya, Yoichi Arai, Hironobu Sasano, Hiroshi Sato, Fumitoshi Satoh, Sadayoshi Ito

ENDOCRINE JOURNAL　57　S647-S647　2010年3月

ISSN： 0918-8959
ECG-gated MDCT of the patent ductus arteriosus in adult cases. Imaging findings and impact on management

K. Takase, S. Matsumoto, S. Yoshida, Y. Morita, H. Saito, S. Takahashi

EUROPEAN HEART JOURNAL　30　490-490　2009年9月

ISSN： 0195-668X
Evaluation of cardiac dyssynchrony in patients with chronic heart failure using cardiacmagnetic resonance imaging

Yuji Wakayama, Koji Fukida, Masanori Hirose, Nobuhiro Yamaguchi, Minako Oikawa, Azusa Ichinose, Kei Takase, Yutaka Kagaya, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　14　(7)　S164-S164　2008年9月

ISSN： 1071-9164
PE-319 Usefulness of Three-Dimensional Analysis with Multi-Detector Row Computed Tomography in the Treatment of Atrial Fibrillation(CT/DSA-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Ichinose Azusa, Kumagai Koji, Takase Kei, Morita Yoshiaki, Kagaya Yutaka, Takahashi Shoki, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　71　404-404　2007年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
【血管炎その臨床所見と画像診断】大動脈疾患

大田英揮, 高瀬圭, 高橋昭喜

臨床画像　21　(8)　840-848　2005年8月
出版者・発行元： (株)メジカルビュー社
ISSN： 0911-1069
Fogarty法およびバルーン血管形成・ステント留置を併用して治療し得た広範囲腸骨大腿動脈閉塞の1例

力丸裕哉, 後藤均, 初貝和明, 石井正, 金田巌, 高瀬圭

日独医報　49　(4)　747-747　2005年2月
出版者・発行元：バイエル薬品(株)
ISSN： 0912-0351
【MDCT利用による診断】大血管,末梢血管領域におけるMultidetector CTの有用性

大田英揮, 高瀬圭, 高橋昭喜

断層映像研究会雑誌　31　(1)　10-14　2004年3月
出版者・発行元：断層映像研究会
ISSN： 0914-8663
CTで診断しえた閉鎖孔ヘルニアの3例

横山元昭, 金田巌, 古田昭彦, 石井正, 石橋悟, 初貝和明, 後藤均, 檜顕成, 工藤博典, 高瀬圭, 力丸裕也

東北医学雑誌　115　(2)　186-187　2003年12月
出版者・発行元：東北医学会
ISSN： 0040-8700
Assessing the extent of breast cancer by multislice helical CT

K Takase, A Furuta, N Shouji, T Takahashi, K Haga, K Igarashi

RADIOLOGY　225　117-117　2002年11月

ISSN： 0033-8419
Evaluation of the artery of Adamkiewicz by multislice helical CT

K Takase, Y Sawamura, K Igarashi, Y Chiba, K Haga

RADIOLOGY　217　136-136　2000年11月

ISSN： 0033-8419
A pitfall of reusing disposable apparatus for endoscopic surgery

Y Sawamura, K Takase, H Saito, S Kikuchi, T Ito

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY　120　(3)　617-617　2000年9月

ISSN： 0022-5223

︎全件表示 ︎最初の5件までを表示

書籍等出版物 21

月刊新医療2025年4月号(第52巻第4号) 巻頭言第84回日本医学放射線学会総会開催にあたって─Radiology for Everyone 高瀬圭［第84 回日本医学放射線学会総会会長］

高瀬圭

株式会社エム・イー振興協会　2025年4月1日

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刊行日2025/3/21 ISSN0910--7991
副腎腫瘍取扱い規約第４版

(作成委員会)日本泌尿器科学会・日本病理学会・日本医学放射線学会・日本内分泌学会・日本内分泌外科学会

メディカルレビュー社　2025年3月31日

ISBN: 9784779228124
画像診断 2025年1月号 Vol.45 No.1 ビギナーのための胸部画像診断 ―Q&A アプローチ― 2025 すとらびすむす

株式会社Gakkenメディカル出版事業部　2024年12月25日

ISBN: 405520115X
原発性アルドステロン症診療マニュアル改訂第4版

編集顧問, 平田結喜緒, 編集, 成瀬光栄, 田辺晶代, 方波見卓行

診断と治療社　2024年6月20日

ISBN: 9784787826626
保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 大田英揮

日本内分泌学会雑誌 99(1)　2023年5月
経静脈的アブレーションによる原発性アルドステロン症の治療;First-in-Human

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 榊原宏幸, 大田英揮

日本内分泌学会雑誌 99(1)　2023年5月
画像診断2022年12月号 Vol.42 No.14 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第6回(全6回)最終回薬事承認後から保険収載までその2

株式会社Gakkenメディカル出版事業部　2022年11月25日

ISBN: 4780905591
画像診断2022年11月号 Vol.42 No.13 新連載人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第5回(全6回) 薬事承認から保険収載に向けて

株式会社学研メディカル秀潤社　2022年10月25日

ISBN: 4780905583
臨床画像2022年10月号 Vol.38 No.10 特別連載沸騰放射線原発性アルドステロン症のラジオ波焼灼治療疾患の基本, 医師主導治験から保険収載まで [第3回] 治験結果から申請, 承認まで

高瀬圭

株式会社メジカルビュー社　2022年9月26日
画像診断2022年10月号 Vol.42 No.12 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第4回(全6回)医療機器開発の3つの障壁

高瀬圭

株式会社学研メディカル秀潤社　2022年9月25日

ISBN: 4780905575
画像診断2022年9月号 Vol.42 No.10 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第3回(全6回)医療機器開発の自験例と課題

高瀬圭

株式会社学研メディカル秀潤社　2022年8月25日

ISBN: 4780905567
【アルドステロンをめぐる臨床課題】原発性アルドステロン症治療におけるラジオ波治療の意義

柳垣聡, 小黒草太, 清治和将, 高瀬圭, 尾股慧, 手塚雄太, 小野美澄, 森本玲, 田中哲洋, 佐藤文俊

糖尿病・内分泌代謝科 55(2)　2022年8月
臨床画像2022年8月号 Vol.38 No.8 特別連載沸騰放射線原発性アルドステロン症のラジオ波焼灼治療疾患の基本, 医師主導治験から保険収載まで [第2回] 開発から医師主導治験までの経緯

高瀬圭

株式会社メジカルビュー社　2022年7月26日
画像診断2022年8月号 Vol.42 No.9 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第2回(全6回)Schopenhauerの言葉に学ぶ医療機器開発の3段階

高瀬圭

株式会社学研メディカル秀潤社　2022年7月25日

ISBN: 4780905559
画像診断2022年7月号 Vol.42 No.8 新連載人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第1回(全6回) Shopenhauer(ショーペンハウアー)の思想と医療機器開発の目的

高瀬圭

株式会社学研メディカル秀潤社　2022年6月25日

ISBN: 4780905540
臨床画像 2022年6月号 Vol.38 No.6 特別掲載沸騰放射線：原発性アルドステロン症のラジオ波焼灼治療疾患の基本，医師主導治験から保険収載まで［第1回］疾患概念と治療の実際

高瀬圭

株式会社メジカルビュー社　2022年5月26日
これから始めるIVR

小黒草太, 鎌田裕基, 高瀬圭

株式会社メジカルビュー社　2022年3月30日

ISBN: 4758321116
IVRのすべて

小黒草太, 鎌田裕基, 高瀬圭

メジカルビュー社　2021年3月28日
人体のメカニズムから学ぶ画像診断技術学

高瀬圭, 佐藤友美

メジカルビュー社　2020年3月10日

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-執筆部分- 1章画像解剖学の基礎 6 泌尿器・生殖器 P. 60-66 4章腹部（消化器、泌尿器、生殖器）の画像診断技術 7 腎・尿路疾患の病態と画像 P. 372-385 8 生殖器疾患の病態と画像 P.386-403 9 その他の病変の病態と画像 P. 404-407
原発性アルドステロン症診療マニュアル

高瀬圭

診断と治療社　2007年11月

ISBN: 9784787815804
3次元医用画像作成秘法マニュアル - Zio M900の基礎から臨床での活用法まで

高瀬圭

メジカルビュー社　2004年10月

︎全件表示 ︎最初の5件までを表示

産業財産権 8

原発性アルドステロン症の検出方法及びモノクローナル抗体

岡村均, 土居雅夫, 佐藤文俊, 笹野公伸, 森本玲, 伊藤貞嘉, 中村保宏, 高瀬圭

特許第6345596号

産業財産権の種類: 特許権
高周波治療用カテーテル

高瀬圭, 清治和将, 日本ライフライン株式会社森謙二, 光宗倫彦

産業財産権の種類: 特許権
診断画像システム

高瀬圭、株式会社島津製作所加治木駿介、能登原大介

産業財産権の種類: 特許権
診断画像システムおよび診断用情報処理装置

高瀬圭、株式会社島津製作所加治木駿介、能登原大介

産業財産権の種類: 特許権
バルーンカテーテル、副腎腫瘍のケミカルアブレーション治療装置および副腎静脈採血装置

高瀬圭, 清治和将, 日本ライフライン株式会社森謙二, 光宗倫彦

産業財産権の種類: 特許権
振動針装置及び針の挿入方法

菊地謙次, 杉山航二郎, 石川拓司, 高瀬圭

産業財産権の種類: 特許権
診断画像システム、レポート⽣成装置およびレポート⽣成⽅法

高瀬圭、株式会社島津製作所加治木駿介、能登原大介

産業財産権の種類: 特許権
診断画像システム

高瀬圭、株式会社島津製作所加治木駿介、能登原大介

産業財産権の種類: 特許権

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 29

新規タウ特異的PET薬剤[F18]SNFT-1によるアルツハイマー病の病態解明

金田朋洋, 古本祥三, 岡村信行, 高瀬圭, 原田龍一

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2023年4月1日～ 2026年3月31日
新規タウ特異的PET薬剤[F18]SNFT-1によるアルツハイマー病の病態解明

金田朋洋, 古本祥三, 岡村信行, 高瀬圭, 原田龍一

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2023年4月1日～ 2026年3月31日
慢性関節炎の微小血管塞栓術に関する基礎実験

小黒草太, 高瀬圭, 石幡浩志, 権田幸祐, 太田信, 中村保宏, 大田英揮, 佐藤友美, 鎌田裕基

2022年4月1日～ 2025年3月31日
[18F]SMBT-1 PETによるMAO-Bの全身・脳の定量イメージングの展開

田代学, 藤本敏彦, 古本祥三, 外山由貴, 渡部浩司, 高瀬圭, 原田龍一, 平岡宏太良, 菊池昭夫, 高浪健太郎

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2021年4月1日～ 2025年3月31日

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SMBT-1の脳における定量計算法に関しては、2コンパートメントモデルを用いた解析法やLogan法が適用できることが確認でき、参照領域として小脳白質や大脳皮質下白質が利用可能であることが再確認できた。健常高齢者とアルツハイマー病(AD)症例の比較においては、AD症例集積が高くなる傾向が示されたが、小脳白質で補正したSUVRを用いた場合のほうが両者の差の検出感度が高くなる傾向があることが示された。進行性核上性麻痺(PSP)症例の脳についても調べたところ、小脳白質で補正した場合よりも大脳皮質白質で補正した場合のほうが、PSP症例の中脳および橋の高集積所見が強調される傾向が示された。本研究課題で開発した「全身・脳hybridプロトコル」を実際に用いてパーキンソン病(PD)症例のPETデータ9例を対象として、脳および全身の解析評価を進めたところ、全身に関してはPD症例の心臓と肝臓の集積が相対的に高い傾向を示し、腎臓への集積が低い傾向を示した。ただ、年齢の違いを補正したところ、心臓および肝臓の高集積所見は弱くなったことから、今後の詳細な検討が必要と考えられた。腫瘍研究に関しては、グリオブラストーマ(GBM)、アストロサイトーマ(Ast)、オリゴデンドログリオーマ(Olg)等を含む病理検体にオートラジオグラフィ(ARG)および抗MAO-B抗体を用いた免疫組織化学染色(IHC)を行い、ARGでは上記の疾患間で目立った差はなかったものの、IHCの視覚的評価ではGBMのうち多くで強陽性となることがわかった。Ast、Olg症例では陽性例が見られたものの、強陽性はみられなかった。全身・脳hybridプロトコルの検証ができ、全身所見が健常者と一部の神経変性疾患患者では異なっている傾向が示された。また、腫瘍診断におけるSMBT-1の有用性も示唆され、引き続き検討が必要であると考えられた。
[18F]SMBT-1 PETによるMAO-Bの全身・脳の定量イメージングの展開

田代学, 藤本敏彦, 古本祥三, 渡部浩司, 高瀬圭, 菊池昭夫, 高浪健太郎

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2021年4月1日～ 2025年3月31日
バルーン拡張型ラジオ波焼灼カテーテルによる原発性アルドステロン症治療

高瀬圭, 森本玲, 石幡浩志, 尾股慧, 小黒草太, 清治和将, 小野美澄, 曽根正人, 西村涼

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2020年4月1日～ 2023年3月31日

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本研究の目指す経血管的病変焼灼のためには、病変部到達のためのカテーテル柔軟性と細径性が求められる一方で、広範囲焼灼のためには大径のデバイスが必要であり、その二律背反の解決が従来は困難であった。その解決手法として、カテーテルの先端に設けたバルーンに導電性を付与し、バルーンを膨張させて直径を増した状態で高周波電流を通電することで、バルーン周辺の組織を加熱焼灼により不活化する方法の確立を目指している。バルーン導電性付与のためには、血管内でバルーンを進める際に剥がれ落ちず、かつ、導電性の良い安定したコーティングが必要であるが、今年度新たに試みたバルーン用素材のメッキ処理法が有用である事が判明した。バルーン素材として折り畳み可能なポリマー材料に、電極機能を付与する特殊導電化処理を実施した。製作した素材の電気的特性と共に、折り畳みからバルーンへの形状変化に対する耐久性を評価した。大径バルーンと小径バルーンでは被覆特性に変化が見られた。並行して、既開発コーティングバルーンによるブタ生体到達性試験を行なった。経静脈的に大腿静脈から左副腎静脈を経由して、副腎中心静脈にデバイス挿入が可能であった。カテーテル管腔冷却下での焼灼により、十分な焼灼性能があると考えられたが、冷却法の最適化と焼灼性能のさらなる向上は課題である。焼灼中のカテコラミン遊離による血圧上昇と頻脈が認められ、交感神経遮断薬を要した。さらに操作性と柔軟性の向上を行ない、副腎静脈の全支脈に選択的に到達して自在に副腎部分焼灼可能なデバイス開発を目指す。完成すれば，既存開発品との使い分けにより、多くのサブタイプの原発性アルドステロン症に対してIVR治療が可能になると考えられる。
蚊の口針と吸血機構を応用した副腎静脈サンプリングおける超選択的採血システムの開発

清治和将, 高瀬圭, 森本玲, 小野美澄

2020年4月1日～ 2023年3月31日
人工知能による救急傷病患者の画像診断支援システム開発研究

工藤大介, 早川峰司, 中川敦寛, 麦倉俊司, 植田琢也, 久志本成樹, 高瀬圭

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2019年4月1日～ 2023年3月31日

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2019年度に東北大学および北海道大学の画像保管サーバにあるCT画像を選択して、50症例分ほど取り出し、本研究用の中央サーバに移管した。その画像を用いて、頭部CTの各解剖学的部位の位置情報均一化アルゴリズムを試みた。位置情報均一化アルゴリズムの開発の具体的方法として以下を行った。脳内各領域の分類は、既存の画像処理技術に加えて、Random walk やRegion proposal (物体検出)で画像の中の区分（臓器や骨の領域など）を判定する（Random walk、Region proposalは顔認証などに使用する技術で、これを改変応用する。試行錯誤したが、直接に位置情報を均一化するのは困難であった。そのため、まずは機械が頭部CT各スライスの正常像を学習して、異常所見を異常だと認識できるように学習させ、アルゴリズムを確立することを目指した。位置情報を均一化しなくても異常所見を指摘できるという形を目指すこととした。これにはGAN(敵対的生成ネットワーク)の技術を用いて学習させて機械に正常像を把握させる方法を使った。つまり機械が正解（正常像）にたどり着くまで、ひたすら学習を繰り返すという方法である。令和2年度中には、機械がある程度正常像を把握できる段階まで進んだ。あるスライスの一部を欠損した画像を機械に提示すると、複数回計算を繰り返した後、正常像を補うことができるというものである。しかし、十分な精度には至っておらず、スライス内の部位によっては、骨を十分に再現できなかったり、実質像や脳室などがぼやけたりという問題がある。これを解決するためには、さらなる学習が必要と考えられ、正常画像を追加で収集する必要が生じた。北海道大学病院から画像データを追加した。現在学習を繰り返すことで精度向上を図っている段階である。
内膜弾性板の表面粗さの高精度超音波計測による動脈硬化症の極早期診断法

金井浩, 荒川元孝, 森翔平, 高瀬圭

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

研究種目：Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

研究機関：Tohoku University

2019年10月7日～ 2022年3月31日

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前年度において，拍動による半径方向の変位を相殺して，血管内膜の粗さをサブミクロンオーダで計測できる手法の原理検討を行い，ファントム実験によって精度を評価した。その成果に基づき，本年度は，以下のように，頸動脈の内弾性板の表面粗さを超音波で非侵襲的に計測するための研究の実施を行った。（１）前年度には計測する超音波ビームが１本であったが，それを多数本に拡大し，内膜表面（内弾性板）に沿った2次元曲面上の粗さを推定するための方法と，そのための計測システムを構築し，さらに精密に作られたファントムと血管によって，その計測の限界がどこにあるかに関する検討を行った。具体的には，超音波ビーム間隔(150ミクロン)は，1拍内で血管が自ら移動する距離（少なくとも数 mm）よりも小さいため，隣り合った超音波ビームを用いて計測された結果の重なりを利用することによって，超音波プローブの範囲(30mm)という広い範囲にわたって表面粗さを一度に計測することが可能となる。これらの原理をファントム実験により確認し修正しながら精度向上を目指した。精巧なファントムを作製し，実験によって評価を行うとともに，計測限界を明らかにした。さらに摘出したブタの動脈に適用したが，ブタの動脈がホルマリン固定で変形しないように，ホルマリン固定の前に固定具に固定する必要がある。そのために必要となる精緻な固定具も，Wilhjelm 教授の長年の研究に基づいて作製することができた。（２）血管が傾いている場合，および血管の軸方向の動きが超音波ビームに垂直でない場合への原理的検討を行った。具体的には，長軸方向変位を推定するブロックマッチングの精度を含め，壁の２次元的な動きを高精度に計測するための原理を検討した。
ヒト心筋の収縮応答性の計測による心臓収縮を引起こす電気的興奮伝導の非侵襲的可視化

金井浩, 荒川元孝, 森翔平, 高瀬圭

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

研究種目：Grant-in-Aid for Challenging Research (Exploratory)

研究機関：Tohoku University

2019年6月28日～ 2022年3月31日

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虚血性心疾患の初期段階である虚血部は，速やかに冠動脈を再灌流させることで心筋の壊死を回避できる。そのため虚血性心疾患の診断・治療では，虚血部の迅速な同定が重要となる．我々は動物実験において虚血部では心筋収縮の伝播速度が正常部に比べて低下することを超音波で計測し報告してきた。しかし心電図R波付近で，どのような現象が起きているかまでは評価されて来なかった。この現象は，心筋虚血部を検出する診断法を確立するためには必要である。そこで本年度，次の研究を行った。まず，正常心筋と虚血心筋の速度波形を超音波計測し比較した。そのため開胸ブタ心臓の心室中隔壁に対し，約400Hzの高フレームレートでの超音波計測を行ないつつ，約３秒後に，左前下行枝を圧迫駆血することで虚血状態の中隔壁を生成し，数秒間にわたり超音波計測を継続した。それぞれの計測で取得したRF信号に位相差トラッキング法を適用し，壁内の多数点で微小振動速度を得た。13本の各ビーム上の中隔壁内の代表点における微小振動速度波形を並べ表示した。その結果を，駆血前から駆血後まで並べ，特に心電図R波周囲において現れる変化を調べた。その結果，各ビーム上の中隔壁内の代表点における微小振動速度波形において，駆血前の健常な状態において次のことがわかった。(1)心房収縮期には，中隔壁は左室側への速度成分をもつ。(2)心電図R波より約25ms前から右心室側の速度をもつ。(3)心電図R波から約25ms後から約25ms間は，左室側への速度成分をもつ（前駆出期）。(4)その後，約50ms間，収縮を休むように，右心室側の成分をもつ。(5)その後，本格的な収縮が始まり，左心室側への速度をもつ。一方，駆血後の虚血部における大きな変化は，上記(3)の前駆出期での左室側への速度成分の継続時間が，2倍近く伸長している。それに伴って上記(4)(5)の期間も後方へ移動している。
MRIアーティファクトフリーとX線視認性を両立させた新規医療用形状記憶合金の創製

金高弘恭, 細田秀樹, 高瀬圭, 沼野智一, 古谷真衣子

2019年4月1日～ 2022年3月31日

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近年、形状記憶効果と超弾性特性を併せ持つ形状記憶合金が着目されるようになった。しかしながら、現在、唯一実用化されているNiTi合金は、生体安全性への懸念、MRI撮影やX線CT撮影時の金属アーティファクト、さらに、血管X線撮影では低い視認性など、臨床的な問題が指摘されている。そこで本研究では、人体と同じ体積磁化率を有し、かつ重元素で構成される形状記憶合金としてAuCuAl合金を作製する。材料特性および生体適合性についての評価結果を材料作製段階までフィードバックしながらMRIアーティファクトフリーとX線視認性を両立させた合金を開発し、その生物学的安全性と臨床的有効性を検証する。本研究では、最新の材料学技術に基づく合金設計および組成制御により、MRIアーティファクトフリーとX線視認性を両立させた新規医療用形状記憶合金を創製することを目的とした。具体的には、人体と同じ体積磁化率を有し、かつ重元素で構成される形状記憶合金としてAuCuAl合金を作製する。材料特性および生体適合性についての評価結果を材料作製段階までフィードバックしながらMRIアーティファクトフリーとX線視認性を両立させた合金を開発し、その生物学的安全性と臨床的有効性を検証した。本年度の研究成果として、開発したAuCuAl合金に対する性能評価を行った。具体的には、①形状可変機能（形状記憶・超弾性）および機械的特性評価、②MRIアーティファクト評価、③X線視認性評価、④生体適合性評価により開発合金の性能評価を行った。
3次元超高周波造影超音波による乳癌腋窩リンパ節微小転移診断法の開発

高澤千晶, 佐藤聡子, 高瀬圭, 伊藤康一, 森菜緒子, 李麗

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2018年4月1日～ 2021年3月31日

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乳癌腋窩リンパ節転移は，転移巣の大きさが2mm以上の粗大転移と2mm未満の微小転移に分けられている．両者では治療方法が異なるため、微小転移なのか粗大転移なのかを判別することが，適切な治療の選択，患者のQOLを保つ上で重要である．我々は①術中造影超音波による1対1対応の画像と病理所見の対比，②リンパ節の3次元超高周波造影超音波撮像法とperfusion defect検出法の開発，③術前3次元超高周波造影超音波によるリンパ節微小転移検出能の確認，を行い，造影超音波によるリンパ節微小転移検出法を確立した。
乳癌術中迅速断端診断のためのMRI拡散強調画像撮像技術の開発

森菜緒子, 田村元, 町田好男, 佐藤聡子, 高瀬圭, 渡部剛

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2018年4月1日～ 2021年3月31日

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臨床用最新MRIシステムを用いて，拡散強調画像を含むMRI撮像を術前に行い、46例程度で画像と病理の比較を行った．正常乳腺，非浸潤性乳管癌および浸潤癌の病変部の標本拡散強調画像の視覚的信号および拡散係数を求め，正常乳腺と比べ腫瘍部を正しく判別できるかを検証した．拡散係数は，浸潤癌，非浸潤癌，正常乳腺の順に高値となった．病理学的な間質の面積比は拡散係数と有意に相関したが、細胞質，核の面積比は拡散係数とは相関しなかった．細胞，核の個数も拡散係数との相関は認めなかった．
多層性血流制御ステントによる解離性大動脈瘤治療のための流体力学的基礎研究

鈴木佑輔, 太田信, 齋木佳克, 高瀬圭, 熊谷紀一郎

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2018年4月1日～ 2021年3月31日

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解離血管モデルを作成した。疑似解離血管モデルを組み込んだ拍動流循環回路を設計した。真腔内にMFMステントを留置する前後で血行動態の解析を行なった。その結果、MFMステント留置前の偽腔では拍動した水流を認め、エントリー部では加速水流を認めた。一方、MFMステント留置後は、ほぼ層流となり、加速水流を認めなかった。以上より偽腔内への水流は残存するが、このMFMステントを通して偽腔内へ流入する水流が整流化され乱流が減少し、偽腔壁へかかるずり応力が減少するだろうと考えられた。この結果より解離性大動脈瘤に対する治療としてMFMステントは有用である可能性が示された。
放射線認知障害：Advanced MR による発症機構解明と動物モデルによる検証

麦倉俊司, 神宮啓一, 森悦朗, 高瀬圭, 金森政之, 高橋昭喜, 森菜緒子, 飯塚統

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2017年4月1日～ 2021年3月31日

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本研究では，小児がん長期生存者を対象に，Advanced MRIを用いて放射線認知障害の発症機構を解明し，照射後認知障害マウスで検証する．小児がん長期生存者において，T2スターを含むAdvanced MRを用いて微細構造変化および脳活動変化を定量化した．また，同被験者に対して認知機能検査である成人機能検査および機能検査を実施し，検査結果を数値化と解析を行った．同時に，同被験者に対して質問紙を用いてQOL評価を実施した．上記認知機能検査とQOL評価に併せて，患者の基本情報を含むデータ整理を行った．
超音波による動脈壁の血圧－歪みヒステリシスと粘弾性特性の非侵襲的計測に関する研究

金井浩, 高瀬圭

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2017年4月1日～ 2020年3月31日

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本研究では，血圧と血管径を同時に計測できる超音波プローブを開発し，血圧－血管径特性から動脈壁の機械的特性と粘弾性率を評価した．さらにこの特別な超音波プローブにより，圧と歪みを血管上の厳密に同じ個所で計測することで，従来法よりも高精度かつ簡便に動脈壁粘弾性の計測を可能とした。本研究を通し，従来の超音波診断検査などで血管壁に異常が発見できない無徴候性で早期の被験者の内皮機能反応性が，健康体に比較して差が現れることが期待できる．また，得られた応力-歪みのヒステリシス特性から，血管壁の弾性特性だけでなく，粘性特性に関する過渡応答に差異が現れることを示したことは今後の医学応用が期待できる。
原発性アルドステロン症治療のための経静脈的焼灼システム開発

高瀬圭, 清治和将, 中村保宏, 佐藤文俊, 森本玲

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2017年4月1日～ 2020年3月31日

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脚の付け根の静脈から副腎静脈に到達して、高血圧の原因となるアルドステロンというホルモンを過剰産生している部位を焼いて治療する柔軟型のラジオ波焼灼カテーテルを開発した。電気的・物理的安全性、目的部位への到達性および有効な焼灼性能を確立した上で、ゲルモデルやウシ摘出副腎、さらにブタ生体での動物実験にて安全で有効な治療が可能な医療機器に改良を重ねた。実寸大ヒト静脈モデルにて最適化させ、安全に経静脈的に病変を治療可能なシステムを基本構築した。
副腎静脈サンプリング技術を応用した原発性アルドステロン症の低侵襲的治療法の開発

清治和将, 高瀬圭, 森本玲

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2016年4月1日～ 2020年3月31日

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副腎静脈内に挿入・留置して閉塞可能なマイクロバルーンカテーテルとガイディングカテーテルを開発した。はじめに3次元血管モデルで操作性を評価し、次にブタ生体副腎を用いて副腎静脈の閉鎖性能とエタノールの静脈内注入による副腎組織の壊死範囲の測定、周囲組織への影響について評価を行った。副腎組織の大部分はうっ血と出血を伴う凝固壊死に陥っていることを確認した。副腎周囲組織にはほとんど損傷を認めなかった。副腎内支脈の閉塞を企図した細径のマイクロバルーンカテーテルによる生体ブタ副腎を用いた評価では、バルーン拡張による細径静脈の損傷と同部からのエタノール漏出を認め、副腎組織の安定した壊死を得ることができなかった。
原発性アルドステロン症：超選択的副腎静脈サンプリングに基づく機能温存手術の完成

石戸谷滋人, 海法康裕, 森本玲, 高瀬圭, 伊藤明宏, 三塚浩二, 川崎芳英

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2016年4月1日～ 2019年3月31日

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原発性アルドステロン症（PA）患者に対する腹腔鏡手術のもたらす生活の質(QOL)改善効果について、RAND 36-Item Health Survey (SF-36)とInternational Prostate Symptom Score (IPSS)を用いて探索した。日本人PA患者は健常者に比べて全体的健康感（GH）が損なわれていた。4つの身体的健康ドメインにおいては、GHは術後に有意に改善が見られた。4つの精神的健康ドメインにおいては、活力、社会生活機能、心の健康が術後有意に改善した。PA患者は夜間頻尿に煩わされていたが、手術介入により有意に改善した。
MRIの普及と利用調査に基づいた医療技術評価分析モデルとガイドラインの作成

佐藤美帆, 町田好男, 別所俊一郎, 高瀬圭, 稲葉洋平, 森菜緒子, 永坂竜男, 引地健生

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2015年4月1日～ 2018年3月31日

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日本は人口当たりで見たMRI保有台数が最も高いものの、その設置と利用が適切であるかの評価を行った報告は少ない。本研究は、国内におけるMRIの設置および利用状況を把握することを目的とした。医療機関の属性、設置機器の詳細、機器の利用状況を問うアンケート調査票を作成し、国内のMRIを保有する施設に対し郵送調査をおこなった。返送された調査票のデータベース化を行い集計を行った。5,437施設中2,272施設からの回答を得られ、回収率は41.8%であった。調査結果から、無床診療所や床数の少ない施設では、常勤の放射線科医や診療放射線技師が在籍していない施設が多いことがわかった。
乳房拡散強調画像推奨プロトコール作成とADC値標準化に関する研究

前川由依, 石橋忠司, 高瀬圭, 高澤千晶, 伊藤康一, 森菜緒子

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2015年4月1日～ 2018年3月31日

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乳癌における拡散強調画像の有用性として良悪性の鑑別における特異度の改善，乳癌のprognostic factorとの相関が知られているが，ガイドラインでは研究レベルで今後が期待されるシーケンスであると記載されるのみである．背景に、DWIは標準化が難しいこと，EPI法による乳房領域での歪み、ノイズ、磁化率アーチファクトがあると考えている．本研究では従来から行われているEPI法に対し，新法としてTSE法のDWI撮像を撮像し，画質と診断能を比較した．結果としてはTSE法は，SNRと歪みを改善するという点でEPI法と比べ優れており，TSE法を用いたDWIの撮像は標準化につながる撮像法と考えられる．
超早期リンパ節転移診断・治療システムの開発

小玉哲也, 宮澤正顯, 高瀬圭, 森士朗, 青木孝文

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

研究種目：Grant-in-Aid for Scientific Research (A)

研究機関：Tohoku University

2014年4月1日～ 2017年3月31日

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リンパ節転移の早期診断・治療という非臨床試験は少なく，この理由として正常マウスのリンパ節の大きさが1-2 mmであるためにリンパ節を肉眼的に同定することが困難であり, かつこの微小なリンパ節を高精度に検出し得る診断機器の開発の遅れに起因しているものと考えられる. 本研究では, ヒトのリンパ節の大きさまでリンパ節が腫脹するマウスを用いて,転移リンパ節に対するマクロCTと造影高周波超音波との画像を融合した超音波/CT高精度診断システム, ならびに転移リンパ節を治療するために,ナノ・マイクロバブルと超音波を用いたリンパ行性薬剤送達法を開発した. 本手法は今後の臨床応用に展開されるものと期待される.
動脈壁内膜側粗さの超音波高精度計測による動脈硬化症の極早期診断の応用に関する研究

金井浩, 長谷川英之, 高瀬圭, 瀧宏文

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2014年4月1日～ 2017年3月31日

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循環器系の疾患の主因は動脈硬化症と考えられている。血圧が高い状態が続くと，血管内腔側表面が粗くなり，動脈硬化症の極早期段階となることが報告されている．表面粗さは10-20μm程度のオーダであるが，従来の超音波診断装置における超音波ビーム方向の空間分解能は超音波の波長である150μm程度であり，空間分解能が不足している．そのため，ミクロンオーダの空間分解能を持つ超音波計測手法が必要とされる．本研究では，超音波信号の位相情報を用いた高空間分解能な表面形状計測手法を開発し，年齢の異なる2グループの被験者の血管表面形状を計測し，得られた表面形状を定量的に比較することで本手法の有効性を評価した。
マイクロバブル造影超音波とMRI画像の3次元的融合による乳癌微小環境の定量化

高澤千晶, 森菜緒子, 高瀬圭, 小玉哲也, 石田孝宣, 宮下穣

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2014年4月1日～ 2017年3月31日

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造影超音波の定量法は、現在臨床の機種ではtime intensity curve解析が搭載されている。Peak intensityやarea under the curveがパラメータとして算出され、これらがMVDと相関することが報告される。我々は、新法としてあるピクセルに着目して、このピクセルの色味が時間軸方向にどのように変化しているのか計測し、変化の度合いの大きいものと小さいものを閾値で分け、変化の大きいものを造影剤の検出されたピクセルとしてdetectするという方法を開発した。今回、新法の定量値が浸潤癌の病理学的MVDと相関することを明らかにした。
原発性アルドステロン症:超選択的副腎静脈サンプリングに基づく機能温存手術の探求

石戸谷滋人, 川崎芳英, 高瀬圭, 海法康裕

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2013年4月1日～ 2016年3月31日

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原発性アルドステロン症患者に対して副腎部分切除術の適応はあるか、両側性原発性アルドステロン症患者を対象に解析した。超選択的副腎静脈サンプリングを施行後、腹腔鏡下両側副腎摘除術（部分温存）を施行した。その結果副腎内の静脈分布図が明らかになった。その結果を基に42例に腹腔鏡下両側副腎摘除術（LBASpc)を施行した。全症例でアルドステロン濃度は正常化した。98％の症例で降圧剤の減量が達成された。ステロイド補充からの離脱率は72%であった。LBASpcは適切な症例選択により、両側副腎腺腫による原発性アルドステロン症の治療オプションとなり得る。
副腎静脈サンプリングにおける超選択的採血システムの開発

清治和将, 高瀬圭, 森本玲, 太田信, 芳賀洋一, 中村保宏

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2012年4月1日～ 2016年3月31日

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原発性アルドステロン症での選択的副腎静脈支脈サンプリングにおいて副腎静脈の各支脈からの採血を容易かつ可能にする最適なデバイス（マイクロカテーテル等）の開発を目的として研究を行った。人工血管モデルやワークステーションを用いたシミュレーション環境下で、マイクロカテーテルの先端形状の相違による吸引時の副腎静脈およびマイクロカテーテルの変形や血流の変化について解析を行った。これらの結果を基に、副腎静脈の各支脈からの採血を容易かつ可能にする最適なマイクロカテーテルの試作品を作成し、実験動物を用いてその性能評価を行った。
高血圧治療における費用効用分析－国民医療費の低下を目指して－

佐藤美帆, 柿原浩明, 高瀬圭, 清治和将, 森本玲

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2012年4月1日～ 2015年3月31日

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日本人の国民病とも言える高血圧は、その合併症も含めると日本の医療費増大の一因と考えられ、そのうちの約１０％と言われる原発性アルドステロン症(PA)は外科的治療により根治可能である。これらを積極的に診断し治療することは社会経済効果が大きいと考え、本研究ではそれらの診断から治療、起こりうる合併症をマルコフモデルを用いてシミュレーションし、費用対効果分析を行った。
副腎静脈サンプリングを応用した原発性アルドステロン症の低侵襲根治術用器具開発

高瀬圭, 太田信, 森本玲, 清治和将, 佐藤文俊, 佐藤美帆, 芳賀洋一, 山内清

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2011年4月1日～ 2014年3月31日

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３DCTデータを基に、実際のカテーテル手技訓練の実用に耐える副腎内静脈分枝を含んだ実物大副腎静脈血管モデルが作成された。バイポーラーラジオ波焼灼針では、10-25mmの副腎腺腫は、３通りの穿刺パターンにて完全焼灼可能であることと、脂肪組織介在下での周辺臓器安全性が示された。IVR臨床治療を施行し、主要評価項目である血中および蓄尿中アルドステロンを正常化が得られ、研究当初の臨床応用目標が達成された。モデル解析にて医療経済的にも有利であるとの結果を得た。
欧米人、日本人でのAdamkiewicz動脈術前MDCT, MRI評価法の最適化

高瀬圭

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2007年～ 2010年

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胸部下行大動脈、胸腹部大動脈の開胸手術およびステントグラフト留置術前には基本的に全例でMDCTによるAdamkiewicz動脈描出を行い、肋間動脈再検および手術法選択に応用した。MDCTでのAdamkiewicz動脈描出能が良好であり、日本人ではMRIはMDCT描出不良例に補助的に使用することが妥当と考えられた。大動脈瘤、解離症例ではAdamkiewicz動脈を栄養する肋間、腰動脈は狭窄、閉塞を合併していることが多くCT、MRIにて同定されたAdamkiewicz動脈近傍の分節動脈が責任血管となっている場合があることが分かった。胸部大動脈瘤手術時に術中冷却液環流と脊髄温度測定により脊髄動脈への側副血行動態が評価できるようになり、これらの情報を追加しさらに研究を発展させる予定である。

︎全件表示 ︎最初の5件までを表示

メディア報道 51

第84回日本医学放射線学会総会の開催にあたって

病院新聞社　病院新聞第2840号　1

2025年4月10日

メディア報道種別: 新聞・雑誌
放射線医療現場市民講座で体験

河北新報社　河北新報　みやぎワイド（14）

2024年11月17日

メディア報道種別: 新聞・雑誌
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座が開催 ——「来て見て触ってみよう！放射線医療」をテーマに，中高生らが体験会に参加

株式会社インナービジョン　インナビネット　取材報告 >新製品発表・学会などの通常取材

2024年11月1日

メディア報道種別: インターネットメディア
放射線診断を分かりやすく説明 10月27日仙台・アエルで市民講座

河北新報社　河北新報　6右下経済&暮らし情報河北Bizナビピックアップ

2024年10月10日

メディア報道種別: 新聞・雑誌
放射線診断を分かりやすく説明 10月27日仙台・アエルで市民講座

河北新報社　河北 Biz ナビ　ピックアップ

2024年10月10日

メディア報道種別: 会誌・広報誌
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』開催のお知らせ（10/27開催）

東北大学病院　新着情報>イベント

2024年9月30日

メディア報道種別: その他
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』開催のお知らせ（10/27開催）

東北大学大学院医学系研究科・医学部　イベント

2024年9月30日

メディア報道種別: その他
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座「来て見て触ってみよう！放射線医療」

河北新報社　こども新聞週刊かほピョンプレス　8下段

2024年9月29日

メディア報道種別: 会誌・広報誌
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』（10/27開催）

東北大学　2024年のイベント

2024年9月20日

メディア報道種別: その他
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座「来て見て触ってみよう！放射線医療」

河北新報社　河北ウイークリーせんだい別冊ジュニアr.2024年秋号　9

2024年9月19日

メディア報道種別: 会誌・広報誌
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座「来て見て触ってみよう！放射線医療」

河北新報社　河北ウイークリーせんだい2024.9.19　9下段

2024年9月19日

メディア報道種別: 会誌・広報誌
河北新報「気になる症状すっきり診断」に放射線診断科科長高瀬圭教授の記事が掲載されました

東北大学病院　お知らせ

2024年5月24日

メディア報道種別: その他
気になる症状すっきり診断（１６９）なかなか治らない高血圧／特別な治療、必要な例も

河北新報社　河北新報　朝刊くらし総合（18）

2024年5月24日

メディア報道種別: 新聞・雑誌
血圧に関する様々な情報を提供する「高血圧チャンネル」

株式会社デイリースポーツ案内広告社（日本経済新聞）　Biz Life Style仙台版　P7（左上）

2024年2月23日

メディア報道種別: 会誌・広報誌
「読売新聞教育ネットワーク主催の高校生向けオンラインセミナー」が読売新聞朝刊に掲載されました

東北大学大学院医学系研究科・医学部　ニュース

2024年1月16日

メディア報道種別: その他
医療、医師の本質に迫る高校生向けオンラインセミナー 6大学で

読売新聞東京本社　読売新聞　27 特別面

2024年1月15日

メディア報道種別: 新聞・雑誌
【宮城】AIの発展と共に放射線科医のニーズはますます高まる‐高瀬圭・東北大学病院放射線診断科教授に聞く◆ Vol.2溝部鈴の『東北大学病院／医学部の現在』

エムスリー株式会社　m3.com ニュース・医療維新　地域情報（県別）地域ニュース

2022年12月2日

メディア報道種別: インターネットメディア
【宮城】放射線診断医が難治性高血圧症の新治療法を開発‐高瀬圭・東北大学病院放射線診断科教授に聞く◆ Vol.1溝部鈴の『東北大学病院／医学部の現在』

エムスリー株式会社　m3.com ニュース・医療維新　地域ニュース地域情報（県別）

2022年11月25日

メディア報道種別: インターネットメディア

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共同研究・競争的資金等の研究課題：経静脈的ラジオ波焼灼による原発性アルドステロン症の低侵襲治療法
「外科的手術をしなくて済む」体への負担少ない高血圧の新治療法東北大学病院

Yahoo! JAPAN　Yahoo! ニュース

2022年5月23日

メディア報道種別: インターネットメディア
「外科的手術をしなくて済む」体への負担少ない高血圧の新治療法東北大学病院

TBS　NEWS DIG(JNN DIG)

2022年5月23日

メディア報道種別: インターネットメディア
「外科的手術をしなくて済む」体への負担少ない高血圧の新治療法東北大学病院

tbc東北放送　Nスタみやぎ（TBS NEWS DIG）

2022年5月23日

メディア報道種別: インターネットメディア
東北大学大学院医学系研究科放射線診断学分野高血圧引き起こす疾患の低侵襲治療開発

関東医事新報社　医事新報　第693号 21 宮城講座クローズアップ

2022年2月20日

メディア報道種別: 新聞・雑誌
気になる症状すっきり診断東北大病院専門ドクターに聞く 113原発性アルドステロン症副腎の腫瘍電流で焼灼ホルモン過剰に

河北新報社　河北新報（19）くらし

2021年11月26日

メディア報道種別: 新聞・雑誌
難治性高血圧に新治療法原発性アルドステロン症原因の腫瘍焼き根治へ

長崎新聞社　長崎新聞　健康 10

2021年10月10日

メディア報道種別: 新聞・雑誌
難治性高血圧に新治療法原発性アルドステロン症で保険適用東北大教授開発原因腫瘍を電流で焼く

株式会社高知新聞社　高知新聞　（17）

2021年9月17日

メディア報道種別: 新聞・雑誌
原発性アルドステロン症難治性高血圧に新治療法原因腫瘍電流で焼き切る

宮崎日日新聞社　宮崎日日新聞　くらし 21

2021年9月14日

メディア報道種別: 新聞・雑誌
難治性高血圧に新治療法原発性アルドステロン症原因の腫瘍を電流で焼く

埼玉新聞社　埼玉新聞　生活情報医療サイエンス（13）

2021年9月8日

メディア報道種別: 新聞・雑誌
原因の腫瘍を電流で焼く難治性高血圧に新治療法原発性アルドステロン症医療保険適用に

株式会社中日新聞社　東京新聞　健康 2（夕刊）

2021年9月8日

メディア報道種別: 新聞・雑誌
【研究成果】難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ−

東北大学大学院医学系研究科・医学部　ニュース

2021年9月8日

メディア報道種別: その他
難治性の高血圧症原発性アルドステロン症新治療法に保険適用原因の腫瘍電流で焼く

株式会社下野新聞社　下野新聞　くらし 18

2021年9月7日

メディア報道種別: 新聞・雑誌
根治期待の新治療法原発性アルドステロン症 6月から保険適用腫瘍を高周波電流で焼く

株式会社茨城新聞社　茨城新聞　健康生活（16）

2021年9月2日

メディア報道種別: 新聞・雑誌
難治性高血圧に新治療法原因の腫瘍を電流で除去原発性アルドステロン症

新日本海新聞社　日本海新聞　くらし（11）

2021年9月2日

メディア報道種別: 新聞・雑誌
体の負担軽い「高血圧」の新たな治療法

Yahoo! JAPAN　Yahoo! ニュース

2021年9月2日

メディア報道種別: インターネットメディア
特集高血圧治療の最前線『体の負担軽い「高血圧」の新たな治療法』

tbc東北放送　Nスタみやぎ

2021年9月2日

メディア報道種別: テレビ・ラジオ番組
難治性高血圧に新治療法針刺し腫瘍を電流で焼く原発性アルドステロン症

千葉日報社　千葉日報（日刊）　健康（12）

2021年8月29日

メディア報道種別: 新聞・雑誌
難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ −

東北大学病院臨床研究推進センター　プレスリリース

2021年8月24日

メディア報道種別: その他
難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ −

東北大学　2021年 | プレスリリース・研究成果

2021年8月24日

メディア報道種別: その他
難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ−

東北大学病院　プレスリリース

2021年8月24日

メディア報道種別: その他
ここまで進んだ最新治療「原発性アルドステロン症」のラジオ波焼灼療法

産経新聞社　夕刊フジ　（8）

2021年8月17日

メディア報道種別: 新聞・雑誌
気になる症状すっきり診断東北大病院専門ドクターに聞く 67子宮筋腫と言われたら

河北新報社　河北新報（20）

2019年12月6日

メディア報道種別: 新聞・雑誌
“がんの疑い見落とし”再発防止策進まずその背景は

NHK　首都圏ネットワーク

2019年1月21日

メディア報道種別: テレビ・ラジオ番組
【気になる症状すっきり診断東北大病院専門ドクターに聞く】⑱健診で「腎臓に腫瘍の疑い」

河北新報社　河北新報（25）

2017年11月17日

メディア報道種別: 新聞・雑誌
河北新報・東北大「東北みらいプロジェクト」高血圧早めの治療を-薬の効かない高血圧に立ち向かう

河北新報社　河北新報

2017年3月31日

メディア報道種別: 新聞・雑誌
医療機器開発産業の最前線

東北放送

2016年10月11日

メディア報道種別: テレビ・ラジオ番組
みちのくワイド東北の医療機器製造、好調復興予算背景に医師と企業連携福島県、参入・海外進出も支援

朝日新聞社　朝日新聞　第2宮城 28

2015年3月3日

メディア報道種別: 新聞・雑誌
薬が効かない高血圧への挑戦

TBS　報道特集

2014年10月11日

メディア報道種別: テレビ・ラジオ番組
くらしナビライフスタイル「ホルモン原因」高血圧に新治療

毎日新聞社　毎日新聞　くらしナビ 15

2014年5月27日

メディア報道種別: 新聞・雑誌
高血圧を引き起こす “原発性アルドステロン症” の新たな治療法

NHK仙台　てれまさむね

2014年5月20日

メディア報道種別: テレビ・ラジオ番組
原発性アルドステロン症の新しい治療

NHK　ニュース7

2014年5月18日

メディア報道種別: テレビ・ラジオ番組
高血圧症に新治療法東北大病院患者の負担減に期待

讀賣新聞社　讀賣新聞　宮城2 30

2014年4月18日

メディア報道種別: 新聞・雑誌
高血圧引き起こす「原発性アルドステロン症」東北大新治療法2例臨床

河北新報社　河北新報

2014年4月15日

メディア報道種別: 新聞・雑誌

︎全件表示 ︎最初の5件までを表示

学術貢献活動 4

第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』

AER5階多目的ホール（中小企業活性化センター）

2024年10月27日～ 2024年10月27日

学術貢献活動種別: その他

詳細を見る詳細を閉じる

共催公益社団法人日本医学放射線学会、東北大学大学院医学系研究科放射線診断学分野、東北大学病院後援宮城県教育委員会、仙台市教育委員会、河北新報社協賛アミン株式会社、キヤノンメディカルシステムズ株式会社、コニカミノルタジャパン株式会社、テルモ株式会社、株式会社フィリップス・ジャパン、富士フイルムメディカル株式会社、GEヘルスケア・ジャパン株式会社協力公益財団法人仙台観光国際協会
東北みらいプロジェクトレクチャーシリーズ「血圧管理で健康長寿」. 薬の効かない高血圧に立ち向かう～放射線診断科医とIVRの挑戦～

東北大学川内キャンパス

2017年3月18日～ 2017年3月18日
第51回ドクターサーチみやぎ健康セミナー市民公開講座「高血圧～3つのチェックポイント～」

仙台メディアテーク

2015年7月12日～ 2015年7月12日
高校生向け医療体験プログラム大学プログラム未来の医療を創る君へオンラインセミナー第1回東北大学画像で病気を診て、針と管で治療する―放射線診断医の世界―

2023年10月7日～

学術貢献活動種別: その他

その他 6

日本核医学会 PET核医学認定医
心臓血管放射線研究会（幹事）
日本脈管学会脈管専門医（評議委員）
日本インターベンショナルラディオロジー学会IVR専門医
日本超音波医学会専門・指導医
日本医学放射線学会放射線診断専門・指導医（理事）

︎全件表示 ︎最初の5件までを表示