Details of the Researcher

PHOTO

Kei Takase
Section
Graduate School of Medicine
Job title
Professor
Degree

  • 博士（医学）（東北大学）

e-Rad No.
60361094

Research History 12

  • 2023/04 - Present
    Tohoku University　School of Medicine　Department Chair, School of Medical Sciences

  • 2015 - Present
    東北大学病院　放射線診断科　科長

  • 2015 - Present
    Tohoku University　Graduate School of Medicine

  • 2010 - 2015
    Tohoku University　Faculty of Medicine

  • 2007 - 2010
    Tohoku University　Faculty of Medicine

  • 2003 - 2007
    Tohoku University　Faculty of Medicine

  • 2005 - 2006
    フンボルト大学シャリテ病院　放射線科　visiting scientist

  • 1997 - 2003
    石巻赤十字病院 放射線科　部長

  • 1994 - 1997
    国立循環器病センター　放射線診療部

  • 1993 - 1994
    公立佐沼総合病院　放射線科

  • 1992 - 1993
    仙台社会保険病院　放射線科

  • 1989 - 1991
    東北大学医学部付属病院　放射線科　研修医

Show all Show first 5

Education 2

  • Tohoku University　医学部　医学科

    1983 - 1989

  • 栃木県立佐野高校

    - 1983

Research Interests 2

  • Interventional Radiology

  • Diagnostic Radiology

Research Areas 2

  • Life sciences / Metabolism and endocrinology /

  • Life sciences / Radiology / Diagnostic Radiology

Awards 4

  1. Certificate of Merit

    2012/11　RSNA (Radiological Society of North America)　What Radiologists Should know and Do for Adrenal Hypertension -Disease Concept, Diagnostic Imaging, Venous Sampling and Interventional Radiological Treatment-

  2. Magna Cum Laude

    2012/03　ECR (European Congress of Radiology)　Adrenal venous sampling revisited - Crucial role in the management of primary aldosteronism patients

  3. Certificate of Merit

    2005　RSNA (Radiological Society of North America)　Non-thrombotic occlusion of hemodialysis access: Disease concept, Diagnosis, and Intervention.

  4. Certificate of Merit

    2003　RSNA (Radiological Society of North America)　How to utilize Color Doppler Ultrasound in IVR of Brescia-Cimino shunt

Papers 315

  1. Identification of Adamkiewicz artery by 4D flow MRI and intra-arterial ultra-high-resolution CT angiography in preoperative assessment of patients with chronic aortic dissection: A case report

    Satoshi Higuchi, Yuta Sato, Hideki Ota, Ryuichi Mori, Yuki Ichinoseki, Hitoshi Nemoto, Shingo Kayano, Kiichiro Kumagai, Yoshikatsu Saiki, Kei Takase

    Radiology Case Reports　20　(3)　1581-1585　2025/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.radcr.2024.12.001 　

    ISSN： 1930-0433

  2. Reduced 18F-FDG uptake in the basal interventricular septum as a predictor of fatal ventricular arrhythmic events in patients with cardiac sarcoidosis. International-journal

    Kouki Takeuchi, Hideaki Suzuki, Kentaro Takanami, Hideki Ota, Yoshitaka Tanaka, Fumiyoshi Fujishima, Hirofumi Watanabe, Kai Susukita, Takumi Inoue, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Takashi Suzuki, Kei Takase, Satoshi Yasuda

    International journal of cardiology　419　132686-132686　2025/01/15

    DOI： 10.1016/j.ijcard.2024.132686 　

    More details Close

    BACKGROUND: Patients with cardiac sarcoidosis (CS) are at an increased risk of fatal ventricular arrhythmic events (FVAE). However, the predictive value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in assessing the risk of FVAE in patients with CS remains uncertain. METHODS: We included data from 121 patients with CS (39 men and 82 women; mean age: 59.5 years) who underwent FDG-PET imaging between March 2008 and November 2020, with follow-ups completed in July 2023. Of these, 82 patients had available cardiac magnetic resonance imaging data, including late gadolinium enhancement (LGE). FDG-PET images were analysed using a polar-map model to determine the regional mean percentage uptake relative to the maximal cardiac 18F-FDG uptake in each of the 17 segments defined by the American Heart Association. RESULTS: Patients experiencing FVAE after FDG-PET (n = 43) showed lower percent uptake in the basal inferoseptal segment compared to those who did not (n = 78) (41.8 ± 15.2 % vs. 54.4 ± 13.8 %, P < 0.001). Patients with a basal inferoseptal percent uptake below the median had a lower FVAE-free survival rate than those with a higher percent uptake (58.1 % vs. 78 % at 5 years, P = 0.007), which was consistent in patients with LGE in the same regions with reduced 18F-FDG uptake. A Cox hazard model indicated that the FVAE risk decreased with a hazard ratio of 0.862 (95 % CI 0.770-0.964) for every 5 % increase in basal inferoseptal percent uptake (P = 0.009). CONCLUSION: Reduced 18F-FDG uptake in the basal interventricular septum, including the inferoseptal segment, may be a valuable predictor of future FVAE in patients with CS.

  3. Magnetic Resonance Imaging Texture Analysis Based on Intraosseous and Extraosseous Lesions to Predict Prognosis in Patients with Osteosarcoma

    Yu Mori, Hainan Ren, Naoko Mori, Munenori Watanuki, Shin Hitachi, Mika Watanabe, Shunji Mugikura, Kei Takase

    Diagnostics　2024/11/15

    DOI： 10.3390/diagnostics14222562 　

  4. Role of radiologists in the diagnosis and management of adrenal disorders.

    Sota Oguro, Hiromitsu Tannai, Hideki Ota, Kazumasa Seiji, Hiroki Kamada, Yoshitaka Toyama, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh, Sadayoshi Ito, Tetsuhiro Tanaka, Hideki Katagiri, Kei Takase

    Endocrine journal　2024/10/10

    DOI： 10.1507/endocrj.EJ24-0156 　

    More details Close

    This study aimed to focus on the role of radiologists in the diagnosis and management of adrenal lesions, particularly primary aldosteronism (PA) and secondary hypertension. As hypertension affects more than one-third of the population in Japan, identifying secondary causes such as PA and adrenal lesions is crucial. Establishing a radiological differential diagnosis of adrenal lesions using advanced imaging techniques, such as computed tomography and magnetic resonance imaging, is crucial. Knowledge of the imaging findings of various benign and malignant adrenal lesions, such as adrenocortical adenomas, cortisol-producing lesions, pheochromocytomas, adrenocortical carcinoma, malignant lymphoma, and metastatic tumors, is necessary. Adrenal venous sampling (AVS) plays a crucial role in accurately localizing aldosterone hypersecretion in PA, especially when imaging fails to provide a clear diagnosis. This paper details the technical aspects of AVS, emphasizing catheterization techniques, anatomical considerations, and the importance of preprocedural imaging for successful sampling. Furthermore, we explore segmental adrenal venous sampling (SAVS), a more refined technique that samples specific adrenal tributary veins, offering enhanced diagnostic accuracy, particularly for microadenomas or challenging cases that may be missed with conventional AVS. The methodology for performing SAVS, along with the interpretation criteria for successful sampling and lateralization, is also outlined. Furthermore, radiologists have initiated treatments for unilateral PA, such as radiofrequency ablation, and play an integral role in the management of adrenal lesions. Collaborative approaches across clinical departments are required to enhance patient management in medical care involving the adrenal gland.

  5. Introduction and evaluation of size-specific DLP for radiation dose estimation in CT examinations. International-journal

    Yutaka Dendo, Keisuke Abe, Shu Onodera, Shingo Kayano, Hideki Ota, Kei Takase

    Journal of radiological protection : official journal of the Society for Radiological Protection　2024/10/09

    DOI： 10.1088/1361-6498/ad8500 　

    More details Close

    The increased utilization of computed tomography (CT) has raised concerns about patient radiation exposure. Effective dose (ED), which requires precise estimation, is crucial for assessing and managing these risks. Traditional ED estimation methods, which are based on the dose-length product (DLP), often lack accuracy due to variations in patient size and anatomy. This study aims to evaluate the efficacy of size-specific DLP (SS-DLP), a novel metric that combines the size-specific dose estimate (SSDE) with scan length, to provide a more accurate estimation of radiation exposure from CT examinations. Focusing on adult chest-abdomen-pelvis (CAP) scans, we calculated SSDE and SS-DLP and utilized two simulation tools, Radimetrics and WAZA-ARI, for a detailed analysis. Our findings indicate that SS-DLP is highly correlated with EDs from Monte Carlo simulations, suggesting its reliability. Additionally, SS-DLP showed a moderate reduction in errors based on patient sex and body mass index compared to traditional DLP-based methods. Thus, SS-DLP offers a more accurate and personalized radiation exposure estimate, potentially enhancing patient safety.

  6. Improving Balloon Pulmonary Angioplasty Through Target Endpoint Optimization With Pressure Catheter and Angiographic Lung Perfusion

    Taijyu Satoh, Nobuhiro Yaoita, Satoshi Higuchi, Kotaro Nochioka, Saori Yamamoto, Haruka Sato, Kaito Yamada, Yusuke Yamada, Kohei Komaru, Naoki Chiba, Mitsuru Nakada, Satoshi Miyata, Hideki Ota, Kei Takase, Satoshi Yasuda

    JACC: Cardiovascular Interventions　17　(20)　2394-2407　2024/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.jcin.2024.08.045 　

    ISSN： 1936-8798

  7. Cost-effectiveness analysis of segmental adrenal venous sampling with radiofrequency ablation for primary aldosteronism in Japan

    Satoru Yanagaki, Kei Omata, Sota Oguro, Hideki Ota, Tomomi Sato, Hiroki Kamada, Hiromitsu Tannai, Yuta Tezuka, Yoshikiyo Ono, Miho Sato, Hiroyuki Ohbe, Kei Takase

    Japanese Journal of Radiology　2024/09/25

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11604-024-01665-6 　

    ISSN： 1867-1071

    eISSN： 1867-108X

    More details Close

    Abstract Purpose The purpose of this study was to evaluate the cost-effectiveness of comprehensive treatment strategy, including segmental adrenal venous sampling (sAVS) and radiofrequency ablation (RFA), versus medication-only strategy for primary aldosteronism. Materials and methods A Markov decision model was developed to compare the cost-effectiveness of a comprehensive treatment strategy and a medication-only strategy for 50-year-old men and women with stage I–III hypertension. The comprehensive treatment strategy included aldosterone/renin ratio measurement, two loading tests, computed tomography, sAVS, drugs, surgery, and RFA. We built a model with a yearly cycle over 32- and 38-year time horizons for men and women, respectively, and four health states: hypertension, heart failure, stroke, and death. The incremental cost-effectiveness ratio (ICER), expressed as Japanese yen per quality-adjusted life-years (QALYs), was estimated, and strategy preference was determined on the basis of 5 million Japanese yen per QALY societal willingness-to-pay threshold. Results The ICERs of the comprehensive treatment strategy over the medication-only strategy were 201,482 and 3,399 JPY per QALY for men and women, respectively. The resultant ICER was less than the 5 million JPY societal willingness-to-pay threshold. Deterministic sensitivity analysis and probabilistic sensitivity analysis revealed that the results varied with the input values, but the comprehensive strategy was likely to be more cost-effective than the medication-only strategy. Conclusion This cost-effectiveness study revealed that a comprehensive treatment strategy including sAVS and RFA was favorable compared with the medication-only strategy for managing stage I–III hypertension in 50-year-old men and women, with acceptable willingness-to-pay thresholds. Secondary abstract This cost-effectiveness study revealed that a comprehensive treatment strategy for primary aldosteronism that included segmental adrenal sampling and radiofrequency ablation was favorable compared with the medication-only strategy for managing stage I–III hypertension in 50-year-old men and women, with acceptable willingness-to-pay thresholds.

  8. Prophylactic splenic artery embolization using n-butyl-2-cyanoacrylate and coils prior to endoscopic necrosectomy in a patient with necrotizing pancreatitis: A case report. International-journal

    Hiroki Kamada, Sota Oguro, Tatsuro Fukushi, Hiromitsu Tannai, Hideki Ota, Kei Takase

    Radiology case reports　19　(8)　3483-3487　2024/08

    DOI： 10.1016/j.radcr.2024.05.027 　

    More details Close

    We present a case of prophylactic endovascular embolization in a 51-year-old man with necrotizing pancreatitis (NP) before undergoing endoscopic necrosectomy (EN). Contrast-enhanced CT imaging revealed the presence of a walled-off necrosis (WON) surrounding the pancreas, with the splenic artery coursing through the cavity. The splenic artery was embolized using n-butyl-2-cyanoacrylate (NBCA) and coils to mitigate the risk of massive bleeding in EN. A newly developed polytetrafluoroethylene (PTFE)-coated microcatheter was used to inject NBCA, enabling embolization of a long segment of the splenic artery without adhering to the vessel wall. Coils were placed distal and proximal to the embolized segment to optimize control. Over 5 sessions of EN, no massive bleeding was encountered. This report demonstrates the benefits of utilizing PTFE-coated microcatheters for enhanced safety and maneuverability during embolization with NBCA. Furthermore, it highlights the importance of prophylactic embolization during EN for managing NP.

  9. Two-session embolization of portosystemic shunt presenting with hepatic encephalopathy via transvenous and trans-paraumbilical approaches: A case report. International-journal

    Hiroki Kamada, Tomomi Sato, Sota Oguro, Hideki Ota, Kei Takase

    Radiology case reports　19　(6)　2112-2116　2024/06

    DOI： 10.1016/j.radcr.2024.02.057 　

    More details Close

    We describe the endovascular embolization of a 65-year-old man with chronic hepatic encephalopathy. A contrast-enhanced computed tomography demonstrated a splenorenal shunt and a recanalized paraumbilical vein as a continuous portal shunt connecting the left branch of the portal vein and the right common femoral vein. A 2-session embolization was performed for the splenorenal shunt. First, the transvenous approach was used for coil embolization of the splenorenal shunt. It was difficult to advance the catheter system to the embolization site, and it was unstable during coil placement. Second, the paraumbilical venous approach was used to place additional coils. The catheter system had good maneuverability and easily reached the embolization site. Additionally, the stable system allowed for densely packed additional coil implantations. This report demonstrated the paraumbilical venous approach's effectiveness in catheter maneuverability and system stability during coil embolization.

  10. Predicting isocitrate dehydrogenase status among adult patients with diffuse glioma using patient characteristics, radiomic features, and magnetic resonance imaging: Multi-modal analysis by variable vision transformer. International-journal

    Takuma Usuzaki, Ryusei Inamori, Takashi Shizukuishi, Yohei Morishita, Hidenobu Takagi, Mami Ishikuro, Taku Obara, Kei Takase

    Magnetic resonance imaging　2024/05/28

    DOI： 10.1016/j.mri.2024.05.012 　

    More details Close

    OBJECTIVES: To evaluate the performance of the multimodal model, termed variable Vision Transformer (vViT), in the task of predicting isocitrate dehydrogenase (IDH) status among adult patients with diffuse glioma. MATERIALS AND METHODS: vViT was designed to predict IDH status using patient characteristics (sex and age), radiomic features, and contrast-enhanced T1-weighted images (CE-T1WI). Radiomic features were extracted from each enhancing tumor (ET), necrotic tumor core (NCR), and peritumoral edematous/infiltrated tissue (ED). CE-T1WI were split into four images and input to vViT. In the training, internal test, and external test, 271 patients with 1070 images (535 IDH wildtype, 535 IDH mutant), 35 patients with 194 images (97 IDH wildtype, 97 IDH mutant), and 291 patients with 872 images (436 IDH wildtype, 436 IDH mutant) were analyzed, respectively. Metrics including accuracy and AUC-ROC were calculated for the internal and external test datasets. Permutation importance analysis combined with the Mann-Whitney U test was performed to compare inputs. RESULTS: For the internal test dataset, vViT correctly predicted IDH status for all patients. For the external test dataset, an accuracy of 0.935 (95% confidence interval; 0.913-0.945) and AUC-ROC of 0.887 (0.798-0.956) were obtained. For both internal and external test datasets, CE-T1WI ET radiomic features and patient characteristics had higher importance than other inputs (p < 0.05). CONCLUSIONS: The vViT has the potential to be a competent model in predicting IDH status among adult patients with diffuse glioma. Our results indicate that age, sex, and CE-T1WI ET radiomic features have key information in estimating IDH status.

  11. 右副腎皮質髄質混合腫瘍と左副腎腫瘍によるサブクリニカルクッシング症候群を合併した一例

    小林 雅幸, 小野 美澄, 宍戸 愛, 矢浦 一磨, 沼畑 貴生, 佐藤 俊宏, 黒澤 聡子, 久保 晴丸, 手塚 雄太, 尾股 慧, 山崎 有人, 高瀬 圭, 伊藤 明宏, 鈴木 貴, 片桐 秀樹

    日本内分泌学会雑誌　100　(1)　341-341　2024/05

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  12. Screening Cutoff Values for the Detection of Aldosterone-Producing Adenoma by LC-MS/MS and a Novel Noncompetitive CLEIA. International-journal

    Yoshikiyo Ono, Yuta Tezuka, Kei Omata, Ryo Morimoto, Yuto Yamazaki, Sota Oguro, Kei Takase, Akihiro Ito, Tatsunari Yoshimi, Satoshi Kojima, Sadayoshi Ito, Hironobu Sasano, Takashi Suzuki, Tetsuhiro Tanaka, Hideki Katagiri, Fumitoshi Satoh

    Journal of the Endocrine Society　8　(6)　bvae080　2024/04/06

    DOI： 10.1210/jendso/bvae080 　

    More details Close

    CONTEXT: Detecting patients with surgically curable aldosterone-producing adenoma (APA) among hypertensive individuals is clinically pivotal. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the ideal method of measuring plasma aldosterone concentration (PAC) because of the inaccuracy of conventional chemiluminescent enzyme immunoassay (CLEIA). However, LC-MS/MS is expensive and requires expertise. We have developed a novel noncompetitive CLEIA (NC-CLEIA) for measuring PAC in 30 minutes. OBJECTIVE: This work aimed to validate NC-CLEIA PAC measurements by comparing them with LC-MS/MS measurements and determining screening cutoffs for both measurements detecting APA. METHODS: We retrospectively measured PAC using LC-MS/MS and NC-CLEIA in 133 patients with APA, 100 with bilateral hyperaldosteronism, and 111 with essential hypertension to explore the accuracy of NC-CLEIA PAC measurements by comparing with LC-MS/MS measurements and determined the cutoffs for detecting APA. RESULTS: Passing-Bablok analysis revealed that the values by NC-CLEIA (the regression slope, intercept, and correlation coefficient were 0.962, -0.043, and 0.994, respectively) were significantly correlated and equivalent to those by LC-MS/MS. Bland-Altman plot analysis of NC-CLEIA and LC-MS/MS also demonstrated smaller systemic errors (a bias of -0.348 ng/dL with limits of agreement of -4.390 and 3.694 within a 95% CI) in NC-CLEIA than LC-MS/MS. The receiver operating characteristic analysis demonstrated that cutoff values for aldosterone/renin activity ratio obtained by LC-MS/MS and NC-CLEIA were 31.2 and 31.5 (ng/dL per ng/mL/hour), with a sensitivity of 91.0% and 90.2% and specificity of 75.4% and 76.8%, respectively, to differentiate APA from non-APA. CONCLUSION: This newly developed NC-CLEIA for measuring PAC could serve as a clinically reliable alternative to LC-MS/MS.

  13. 原発性アルドステロン症治療の衆知を集める(最適な治療の解は?) 腹腔鏡下副腎摘除術が原発性アルドステロン症患者のQOL、心機能に与える影響

    川崎 芳英, 祢津 晋久, 手塚 ゆうた, 小野 美澄, 尾股 慧, 小黒 草太, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 高瀬 圭, 佐藤 文俊, 片桐 秀樹, 伊藤 明宏

    日本内分泌外科学会雑誌　41　(Suppl.1)　S136-S136　2024/04

    Publisher: (一社)日本内分泌外科学会

    ISSN： 2434-6535

    eISSN： 2758-8785

  14. Identifying key factors for predicting O6-Methylguanine-DNA methyltransferase status in adult patients with diffuse glioma: a multimodal analysis of demographics, radiomics, and MRI by variable Vision Transformer. International-journal

    Takuma Usuzaki, Kengo Takahashi, Ryusei Inamori, Yohei Morishita, Takashi Shizukuishi, Hidenobu Takagi, Mami Ishikuro, Taku Obara, Kei Takase

    Neuroradiology　2024/03/12

    DOI： 10.1007/s00234-024-03329-8 　

    More details Close

    PURPOSE: This study aimed to perform multimodal analysis by vision transformer (vViT) in predicting O6-methylguanine-DNA methyl transferase (MGMT) promoter status among adult patients with diffuse glioma using demographics (sex and age), radiomic features, and MRI. METHODS: The training and test datasets contained 122 patients with 1,570 images and 30 patients with 484 images, respectively. The radiomic features were extracted from enhancing tumors (ET), necrotic tumor cores (NCR), and the peritumoral edematous/infiltrated tissues (ED) using contrast-enhanced T1-weighted images (CE-T1WI) and T2-weighted images (T2WI). The vViT had 9 sectors; 1 demographic sector, 6 radiomic sectors (CE-T1WI ET, CE-T1WI NCR, CE-T1WI ED, T2WI ET, T2WI NCR, and T2WI ED), 2 image sectors (CE-T1WI, and T2WI). Accuracy and area under the curve of receiver-operating characteristics (AUC-ROC) were calculated for the test dataset. The performance of vViT was compared with AlexNet, GoogleNet, VGG16, and ResNet by McNemar and Delong test. Permutation importance (PI) analysis with the Mann-Whitney U test was performed. RESULTS: The accuracy was 0.833 (95% confidence interval [95%CI]: 0.714-0.877) and the area under the curve of receiver-operating characteristics was 0.840 (0.650-0.995) in the patient-based analysis. The vViT had higher accuracy than VGG16 and ResNet, and had higher AUC-ROC than GoogleNet (p<0.05). The ED radiomic features extracted from the T2-weighted image demonstrated the highest importance (PI=0.239, 95%CI: 0.237-0.240) among all other sectors (p<0.0001). CONCLUSION: The vViT is a competent deep learning model in predicting MGMT status. The ED radiomic features of the T2-weighted image demonstrated the most dominant contribution.

  15. Investigating the cut-off values of captopril challenge test for primary aldosteronism using the novel chemiluminescent enzyme immunoassay method: a retrospective cohort study. International-journal

    Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kengo Kambara, Hiroki Kamada, Sota Oguro, Yuto Yamazaki, Celso E Gomez-Sanchez, Akihiro Ito, Hironobu Sasano, Kei Takase, Tetsuhiro Tanaka, Hideki Katagiri, Fumitoshi Satoh

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/03/08

    DOI： 10.1038/s41440-024-01594-x 　

    More details Close

    The measurement evolution enabled more accurate evaluation of aldosterone production in hypertensive patients. However, the cut-off values for novel assays have been not sufficiently validated. The present study was undertaken to validate the novel chemiluminescent enzyme immunoassay for aldosterone in conjunction with other methods. Moreover, we also aimed to establish a new cut-off value for primary aldosteronism in the captopril challenge test using the novel assay. First, we collected 390 plasma samples, in which aldosterone levels measured using liquid chromatography-mass spectrometry ranged between 0.18 and 1346 ng/dL. The novel chemiluminescent enzyme immunoassay showed identical correlation of plasma aldosterone with liquid chromatography-mass spectrometry, in contrast to conventional radioimmunoassay. Further, we enrolled 299 and 39 patients with primary aldosteronism and essential hypertension, respectively. Plasma aldosterone concentrations measured using the novel assay were lower than those measured by radioimmunoassay, which resulted in decreased aldosterone-to-renin ratios. Subsequently, positive results of the captopril challenge test based on radioimmunoassay turned into "negative" based on the novel assay in 45% patients with primary aldosteronism, using the conventional cut-off value (aldosterone-to-renin activity ratio > 20 ng/dL per ng/mL/h). Receiver operating characteristic curve analysis demonstrated that aldosterone-to-renin activity ratios > 8.2 ng/dL per ng/mL/h in the novel assay was compatible with the conventional diagnosis (sensitivity, 0.874; specificity, 0.980). Our study indicates the great measurement accuracy of the novel chemiluminescent enzyme immunoassay for aldosterone, and the importance of measurement-adjusted cut-offs in the diagnosis of primary aldosteronism.

  16. 心臓サルコイドーシス患者の致死的心室不整脈イベント予測における心筋18F-FDG PETの予後予測能(Prognostic Value of Cardiac 18F-fluorodeoxyglucose Positron Emission Tomography in Predicting Fatal Ventricular Arrhythmic Events among Patients with Cardiac Sarcoidosis)

    Takeuchi Kouki, Suzuki Hideaki, Takanami Kentaro, Tanaka Yoshitaka, Susukita Kai, Inoue Takumi, Arai Marina, Hayashi Hideka, Nochioka Kotaro, Takahama Hiroyuki, Takase Kei, Yasuda Satoshi

    日本循環器学会学術集会抄録集　88回　OE27-7　2024/03

    Publisher: (一社)日本循環器学会

  17. Verification of the effect of data-driven brain motion correction on PET imaging. International-journal

    Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Kazuma Akimoto, Akihito Usui, Hirofumi Kawakami, Akie Katsuki, Nozomu Uetake, Yutaka Dendo, Yoshitaka Tanaka, Hiroyasu Kodama, Kei Takase, Tomohiro Kaneta

    PloS one　19　(7)　e0301919　2024

    DOI： 10.1371/journal.pone.0301919 　

    More details Close

    INTRODUCTION: Brain positron emission tomography/computed tomography (PET/CT) scans are useful for identifying the cause of dementia by evaluating glucose metabolism in the brain with F-18-fluorodeoxyglucose or Aβ deposition with F-18-florbetaben. However, since imaging time ranges from 10 to 30 minutes, movements during the examination might result in image artifacts, which interfere with diagnosis. To solve this problem, data-driven brain motion correction (DDBMC) techniques are capable of performing motion corrected reconstruction using highly accurate motion estimates with high temporal resolution. In this study, we investigated the effectiveness of DDBMC techniques on PET/CT images using a Hoffman phantom, involving continuous rotational and tilting motion, each expanded up to approximately 20 degrees. MATERIALS AND METHODS: Listmode imaging was performed using a Hoffman phantom that reproduced rotational and tilting motions of the head. Brain motion correction processing was performed on the obtained data. Reconstructed images with and without brain motion correction processing were compared. Visual evaluations by a nuclear medicine specialist and quantitative parameters of images with correction and reference still images were compared. RESULTS: Normalized Mean Squared Error (NMSE) results demonstrated the effectiveness of DDBMC in compensating for rotational and tilting motions during PET imaging. In Cases 1 and 2 involving rotational motion, NMSE decreased from 0.15-0.2 to approximately 0.01 with DDBMC, indicating a substantial reduction in differences from the reference image across various brain regions. In the Structural Similarity Index (SSIM), DDBMC improved it to above 0.96 Contrast assessment revealed notable improvements with DDBMC. In continuous rotational motion, % contrast increased from 42.4% to 73.5%, In tilting motion, % contrast increased from 52.3% to 64.5%, eliminating significant differences from the static reference image. These findings underscore the efficacy of DDBMC in enhancing image contrast and minimizing motion induced variations across different motion scenarios. CONCLUSIONS: DDBMC processing can effectively compensate for continuous rotational and tilting motion of the head during PET, with motion angles of approximately 20 degrees. However, a significant limitation of this study is the exclusive validation of the proposed method using a Hoffman phantom; its applicability to the human brain has not been investigated. Further research involving human subjects is necessary to assess the generalizability and reliability of the presented motion correction technique in real clinical scenarios.

  18. Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis

    Shunji Mugikura, Naoko Mori, Miyeong Gang, Shigenori Kanno, Kazutaka Jin, Shin-Ichiro Osawa, Nobukazu Nakasato, Kei Takase

    Journal of Clinical Imaging Science　13　38-38　2023/12/22

    Publisher: Scientific Scholar

    DOI： 10.25259/jcis_77_2023 　

    ISSN： 2156-7514

    eISSN： 2156-5597

    More details Close

    Objectives: To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides. Material and Methods: Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox. Results: Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions. Conclusion: By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.

  19. Transvenous Radiofrequency Catheter Ablation for an Aldosterone-Producing Tumor of the Left Adrenal Gland: A First in Human Case Report. International-journal

    Sota Oguro, Hideki Ota, Satoru Yanagaki, Masahiro Kawabata, Hiroki Kamada, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Hiroaki Toyama, Kouta Tanimoto, Daisuke Konno, Masanori Yamauchi, Yuki Niwa, Hisao Miyamoto, Kenji Mori, Tetsuhiro Tanaka, Hiroshi Ishihata, Kei Takase

    Cardiovascular and interventional radiology　46　(12)　1666-1673　2023/12

    DOI： 10.1007/s00270-023-03584-x 　

    More details Close

    PURPOSE: To describe a novel technique of transvenous radiofrequency catheter ablation of an aldosterone-producing adenoma (APA) of the left adrenal gland using the GOS System (Japan Lifeline, Tokyo, Japan). Using the GOS system, a flexible radiofrequency tip catheter can be inserted into the adrenal central and tributary veins, the drainers for functional tumors. MATERIALS AND METHODS: An APA at the left adrenal gland, which was diagnosed by segmental adrenal venous sampling following administration of 0.25 mg cosyntropin, was ablated using the GOS catheter inserted into adrenal tributary veins via a right femoral vein 7-Fr sheath. The effect of radiofrequency ablation on APA was assessed using the international consensus on surgical outcomes for unilateral primary aldosteronism (PA). RESULTS: No device-related complications were observed. The patient was deeply sedated under blood pressure and heart rate control with continuous administration of β-blockers. Then, the tumor and surrounding adrenal gland were cauterized at 7000 J two times each in sequence. The output time was 7-11 min for each ablation and 80 min in total. For blood pressure and pulse rate control, esmolol hydrochloride and phentolamine mesylate were used. The contrast enhancement of APA disappeared on dynamic CT immediately after the procedure. PA was biochemically cured until 12 months after the procedure. CONCLUSION: Using the radiofrequency device with the GOS catheter and system is a method for cauterizing adrenal tumors from blood vessels. This approach resulted in a marked reduction in aldosterone concentrations and a complete biochemical cure of PA over the observation period.

  20. A case of percutaneous transhepatic portal vein stenting without using iodinated contrast media for post pancreatectomy portal vein obstruction. International-journal

    Hinano Anaba, Sota Oguro, Hideki Ota, Satoru Yanagaki, Tomomi Sato, Kei Nakagawa, Michiaki Unno, Kei Takase

    BJR case reports　9　(6)　20220116-20220116　2023/11

    DOI： 10.1259/bjrcr.20220116 　

    More details Close

    Postoperative portal vein obstruction could occur as a complication of portal vein reconstruction during hepatic lobectomy or pancreaticoduodenectomy. We report a case of patient with postoperative portal vein obstruction treated with percutaneous transhepatic portal vein stenting without using iodinated contrast media owing to a history of severe allergic reactions. Under ultrasound guidance, carbon dioxide angiography, and appropriate device selection, successful stenting was achieved without serious adverse events. After the operation, portal vein blood flow and clinical symptoms improved, enabling adjuvant chemotherapy. To the best of our knowledge, this is the first case report wherein percutaneous transhepatic portal vein stenting was successfully performed in a patient with an iodine allergy.

  21. 「ACSにおける画像診断/Imaging in Acute care surgery」 Hybrid ERでCTに基づいたacute care surgeryを遂行するには放射線部の協力が必要である

    谷河 篤, 藤田 基生, 小野 勝範, 勝田 賢, 大田 英揮, 高瀬 圭, 久志本 成樹

    Japanese Journal of Acute Care Surgery　13　(Suppl.)　95-95　2023/10

    Publisher: (一社)日本Acute Care Surgery学会

    eISSN： 2436-102X

  22. アキシャル加算平均画像を用いた胸部単純CT検査におけるSize-Specific Dose Estimatesの有用性

    田頭 豊, 安部 圭亮, 小野寺 崇, 茅野 伸吾, 大田 英揮, 高瀬 圭

    日本放射線技術学会雑誌　79　(9)　1038-1038　2023/09

    Publisher: (公社)日本放射線技術学会

    ISSN： 0369-4305

    eISSN： 1881-4883

  23. Size-Specific Dose Estimatesと撮影長による新たな実効線量換算係数の考案

    安部 圭亮, 田頭 豊, 小野寺 崇, 茅野 伸吾, 大田 英揮, 高瀬 圭

    日本放射線技術学会雑誌　79　(9)　1102-1102　2023/09

    Publisher: (公社)日本放射線技術学会

    ISSN： 0369-4305

    eISSN： 1881-4883

  24. MRI画像の前立腺癌セグメンテーションにおけるマルチシーケンス画像を用いたDeep Learningの有用性

    村上 弘晃, 河端 真広, 高屋 英知, 小林 智哉, 大田 英揮, 高瀬 圭, 植田 琢也

    日本放射線技術学会雑誌　79　(9)　1075-1075　2023/09

    Publisher: (公社)日本放射線技術学会

    ISSN： 0369-4305

    eISSN： 1881-4883

  25. Role of Magnetic Resonance Imaging in the Screening of Closed Spinal Dysraphism.

    Hidekazu Aoki, Shunji Mugikura, Reizo Shirane, Toshiaki Hayashi, Tomomi Kimiwada, Kiyohide Sakai, Keiko Ainoya, Hideki Ota, Kei Takase, Yoshihisa Shimanuki

    Neurologia medico-chirurgica　2023/08/30

    DOI： 10.2176/jns-nmc.2023-0002 　

    More details Close

    Closed spinal dysraphism (CSD) encompasses a heterogeneous group of spinal cord deformities, which can be accompanied by several types of skin stigmata. These skin stigmata may include inconspicuous features, such as sacral dimples and deformed gluteal clefts, but the association between such mild skin stigmata and CSD is uncertain. This study aimed to reevaluate the indication for magnetic resonance imaging (MRI) in patients with skin stigmata while considering the indication for surgery. A retrospective analysis was conducted on magnetic resonance images of 1255 asymptomatic children with skin stigmata between 2003 and 2015. Skin stigmata classification was based on medical chart data. All subtypes of CSDs except for filum terminale lipomas (FTL), FTL thicker than 2 mm or with low conus medullaris, were considered to meet the surgical indication. CSD prevalence was estimated while considering the surgical indications and assessed after excluding all FTL cases. Skin stigmata were classified into seven types, dimple, deformed gluteal cleft, hair, subcutaneous mass, appendage, discoloration, and protruding bone, and included 1056 isolated and 199 complex ones. The prevalence of CSD was 19.5%, 6.8%, and 0.5% among patients with isolated dimples (n = 881) and 13.9%, 5.8%, and 0.7% among those with isolated deformed gluteal clefts (n = 136) for all cases, surgical indications, and patients without FTL, respectively. Dimples and deformed gluteal clefts had a low prevalence of CSD requiring surgical intervention, and cases without FTL were rare. Asymptomatic patients with mild skin stigmata may not require immediate MRI.

  26. Utility of Carbon Dioxide Venography and Intraprocedural CT for Adrenal Venous Sampling in Patients with an Allergy to Iodinated Contrast Media. International-journal

    Hiroki Kamada, Kazumasa Seiji, Sota Oguro, Hideki Ota, Satoru Yanagaki, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

    Journal of vascular and interventional radiology : JVIR　2023/07/31

    DOI： 10.1016/j.jvir.2023.07.021 　

    More details Close

    PURPOSE: To assess the diagnostic performance of carbon dioxide (CO2) and intraprocedural unenhanced computed tomography (CT) for adrenal venous sampling (AVS) (CO2-intraprocedural unenhanced CT-AVS) in patients with primary aldosteronism (PA) and a history of iodine contrast medium allergy. MATERIALS AND METHODS: CO2-intraprocedural unenhanced CT-AVS was performed in 18 patients with iodine contrast media allergies at the authors' hospital between December 2015 and January 2021. CT and noncontrast magnetic resonance angiography were used to evaluate the preoperative adrenal vein anatomy. CO2 venography was performed to confirm adrenal vein catheterization. Additionally, intraprocedural unenhanced CT was also performed to confirm catheter position in the right adrenal gland. RESULTS: In all cases in which CO2-intraprocedural unenhanced CT-AVS was performed, the right and left adrenal veins were catheterized appropriately, leading to a localized diagnosis. Catheterization of the left adrenal vein was confirmed using CO2 venography in all cases. In 7 of the 18 cases, CO2 venography demonstrated selection of the right adrenal vein. In 15 of 18 cases, intraprocedural unenhanced CT demonstrated selection of the right adrenal vein. CONCLUSIONS: CO2-intraprocedural unenhanced CT-AVS demonstrated the same diagnostic ability for PA localization as conventional AVS with iodine contrast media. The proposed method is clinically feasible for AVS, in which iodine contrast media use is restricted.

  27. Type 2 Endoleak Detection After Endovascular Aneurysm Repair: Can Low-Flow Endoleaks Also Be Visualized in Silicon-Photomultiplier-Based Positron Emission Tomography/Computed Tomography Scans? International-journal

    Ayaka Harigai, Yoshitaka Toyama, Michihisa Umetsu, Kentaro Takanami, Kei Takase

    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists　15266028231185237-15266028231185237　2023/07/02

    DOI： 10.1177/15266028231185237 　

    More details Close

    PURPOSE: To present a novel clinical application of silicon-photomultiplier-based positron emission tomography (SiPM-based PET)/computed tomography (CT), detecting a type II endoleak 5 years after endovascular aneurysm repair (EVAR). TECHNIQUE: SiPM-based PET/CT scans with a standard whole-body protocol were performed for a 73-year-old man with a past medical history of abdominal aortic aneurysms treated with EVAR and currently under investigation of his duodenal papillary carcinoma. The PET/CT demonstrated 18F-fluorodeoxyglucose (FDG) accumulation outside the stent graft in the native sac of the aneurysm. The site of accumulation corresponded to that of the contrast enhancement depicted in the CT angiography taken 1 month earlier. Another CT scan performed 3 months later revealed enlargement of the aneurysm. CONCLUSION: SiPM-based PET/CT, with its superior sensitivity and spatial resolution over conventional PET/CT, can detect type II low-flow endoleaks. CLINICAL IMPACT: Abnormal intra-aneurysmal FDG activity incidentally detected on SiPM-based PET/CT is worthy of attention because it may be indicative of endoleaks. Additional imaging using different modalities should be considered so that the patient would not miss the additional treatment opportunity upon observing sac enlargement. For patients with contraindications for iodine CT contrast media, SiPM-based PET/CT would serve as a suitable alternative.

  28. Clinical impact of radiation-induced myocardial damage detected by cardiac magnetic resonance imaging and dose-volume histogram parameters of the left ventricle as prognostic factors of cardiac events after chemoradiotherapy for esophageal cancer. International-journal

    Rei Umezawa, Hideki Ota, Hidenobu Takagi, Noriyuki Kadoya, Yujiro Nakajima, Noriyoshi Takahashi, Takaya Yamamoto, Kei Takase, Keiichi Jingu

    Journal of radiation research　64　(4)　702-710　2023/06/12

    DOI： 10.1093/jrr/rrad040 　

    More details Close

    This prospective study aimed to evaluate whether radiation (RT)-induced myocardial damage by cardiac magnetic resonance (CMR) imaging could be a predictor of cardiac events after chemoradiotherapy (CRT) for esophageal cancer and determine the dose-volume histogram (DVH) parameters of the left ventricle (LV) in predicting cardiac events. CMR imaging was performed before and 6 months after CRT in patients receiving definitive CRT. RT-induced myocardial damage was defined as abnormal CMR findings indicating myocardial fibrosis corresponding to an isodose line of ≥30 Gy. The cutoff values of the LV DVH parameters were calculated using the receiver operating characteristic curve based on the presence of RT-induced myocardial damage. The prognostic factors related to cardiac events of Grade 3 or higher were examined. Twenty-three patients were enrolled in the study. RT-induced myocardial damage by late gadolinium enhancement and/or an increase of 100 ms or higher in native T1 post-CRT was detected in 10 of the 23 patients. LV V45 was the best predictive factor for RT-induced myocardial damage with a cutoff value of 2.1% and an area under the curve of 0.75. The median follow-up period was 82.1 months. The 5- and 7-year cumulative incidences of cardiac events of Grade 3 or higher were 14.7 and 22.4%, respectively. RT-induced myocardial damage and LV V45 were significant risk factors (P = 0.015 and P = 0.013, respectively). RT-induced myocardial damage is a significant predictor of cardiac events. LV V45 is associated with RT-induced myocardial damage and subsequent cardiac events.

  29. Erratum to "Carotid computed tomography angiography after cobalt-based alloy carotid artery stenting using ultra-high-resolution computed tomography with model-based iterative reconstruction" [Radiol Case Rep 2021;16:3721-8]. International-journal

    Shingo Kayano, Hideki Ota, Yoshimichi Sato, Toshiki Endo, Kuniyasu Niizuma, Ichiro Suzuki, Tsuyoshi Kawamura, Kei Takase

    Radiology case reports　18　(6)　2324-2324　2023/06

    DOI： 10.1016/j.radcr.2023.03.021 　

    More details Close

    [This corrects the article DOI: 10.1016/j.radcr.2021.09.003.].

  30. Improvement of Imaging Conditions to Improve the Detection Rate of Head and Neck Cancer by Positron Emission Tomography/Computed Tomography Examination. Peer-reviewed

    Hayato Odagiri, Kentaro Takanami, Tomohiro Kaneta, Akihito Usui, Ikuho Kojima, Hiroyasu Kodama, Shin Saitou, Yoshitaka Tanaka, Yutaka Dendo, Kei Takase

    The Tohoku journal of experimental medicine　260　(2)　141-147　2023/05/30

    DOI： 10.1620/tjem.2023.J026 　

    More details Close

    Positron emission tomography (PET)/computed tomography (CT) has improved sensitivity and resolution using silicon photomultiplier as a photosensor. Previously, only a fixed setting was available for the shooting time of 1 bed, but now, the shooting time can be changed for each bed. Time can be shortened or extended depending on the target area. A few studies reported on image reconstruction conditions for head and neck cancer in whole-body PET/CT examinations. Thus, this study aimed to optimize the imaging conditions of the head and neck region during whole-body imaging. A cylindrical acrylic container with a 200 mm diameter was used to simulate the head and neck area using a PET/CT system equipped with a semiconductor detector. Spheres of 6-30 mm in diameter were enclosed in the 200 mm diameter cylindrical acrylic vessel. Radioactivity in 18F solution (Hot:BG ratio 4:1) was enclosed in a phantom following the Japanese Society of Nuclear Medicine (JSNM) guidelines. Background radioactivity concentration was 2.53 kBq/mL. List mode acquisition of 1,800 s was collected at 60-1,800 s with the field of view of 700 mm and 350 mm. The image was reconstructed by resizing the matrix to 128 × 128, 192 × 192, 256 × 256, and 384 × 384, respectively. The imaging time per bed in the head and neck should be at least 180 s, and the reconstruction conditions should be a field of view (FOV) of 350 mm, matrix sizes of ≥ 192, and a Bayesian penalized likelihood (BPL) reconstruction with a β-value of 200. This allows detection of > 70% of the 8-mm spheres in the images.

  31. 保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

    高瀬 圭, 小黒 草太, 尾股 慧, 小野 美澄, 手塚 雄太, 森本 玲, 佐藤 文俊, 大田 英揮

    日本内分泌学会雑誌　99　(1)　317-317　2023/05

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  32. 経静脈的アブレーションによる原発性アルドステロン症の治療 First-in-Human

    高瀬 圭, 小黒 草太, 尾股 慧, 小野 美澄, 手塚 雄太, 森本 玲, 佐藤 文俊, 榊原 宏幸, 大田 英揮

    日本内分泌学会雑誌　99　(1)　317-317　2023/05

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  33. 保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

    高瀬 圭, 小黒 草太, 尾股 慧, 小野 美澄, 手塚 雄太, 森本 玲, 佐藤 文俊, 大田 英揮

    日本内分泌学会雑誌　99　(1)　317-317　2023/05

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  34. 経静脈的アブレーションによる原発性アルドステロン症の治療 First-in-Human

    高瀬 圭, 小黒 草太, 尾股 慧, 小野 美澄, 手塚 雄太, 森本 玲, 佐藤 文俊, 榊原 宏幸, 大田 英揮

    日本内分泌学会雑誌　99　(1)　317-317　2023/05

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  35. 無症候性の閉鎖性脊椎癒合不全のスクリーニングにおけるMRIの役割

    青木 英和, 麦倉 俊司, 白根 礼造, 林 俊哲, 君和田 友美, 坂井 清英, 相野谷 慶子, 大田 英揮, 高瀬 圭, 島貫 義久

    日本小児放射線学会雑誌　39　(Suppl.)　35-35　2023/05

    Publisher: (一社)日本小児放射線学会

    ISSN： 0918-8487

    eISSN： 2432-4388

  36. High-flow arteriovenous malformation in the finger with transvenous ethanolamine oleate sclerotherapy using an arterial tourniquet and microballoon occlusion: A case report

    Hiromitsu Tannai, Sota Oguro, Munetomo Nagao, Hideki Ota, Kei Takase

    Radiology Case Reports　18　(5)　1973-1977　2023/05

    Publisher: Elsevier BV

    DOI： 10.1016/j.radcr.2023.02.048 　

    ISSN： 1930-0433

  37. 18 F-FDG PET/CT Imaging Post Heart Transplantation Depicts High Accumulation at Sites of Previous Ventricular Assist Device Insertion. International-journal

    Yoshitaka Toyama, Masayuki Otani, Nobuhiro Yaoita, Kentaro Takanami, Kei Takase

    Clinical nuclear medicine　48　(4)　366-369　2023/04/01

    DOI： 10.1097/RLU.0000000000004580 　

    More details Close

    A 37-year-old man with previous heart transplantation for dilated cardiomyopathy underwent screening for malignancy under posttransplantation immunosuppression. 18 F-FDG PET/CT revealed uptake in 2 peritoneal sites of the pericardium that corresponded to the insertion sites of a left ventricular assist device that was used before transplantation. Additional abnormal uptake in the right axillary artery, aortic arch, and left femoral artery corresponded to the insertion sites for arterial inflow during cardiopulmonary bypass. Knowledge that FDG accumulation may occur at the insertion sites of an extracorporeal-circulation device enables unnecessary tests to be avoided.

  38. Principal component analysis of texture features for grading of meningioma: not effective from the peritumoral area but effective from the tumor area. International-journal

    Naoko Mori, Shunji Mugikura, Toshiki Endo, Hidenori Endo, Yo Oguma, Li Li, Akira Ito, Mika Watanabe, Masayuki Kanamori, Teiji Tominaga, Kei Takase

    Neuroradiology　65　(2)　257-274　2023/02

    DOI： 10.1007/s00234-022-03045-1 　

    More details Close

    PURPOSE: To investigate whether texture features from tumor and peritumoral areas based on sequence combinations can differentiate between low- and non-low-grade meningiomas. METHODS: Consecutive patients diagnosed with meningioma by surgery (77 low-grade and 28 non-low-grade meningiomas) underwent preoperative magnetic resonance imaging including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast-enhanced T1WI (CE-T1WI). Manual segmentation of the tumor area was performed to extract texture features. Segmentation of the peritumoral area was performed for peritumoral high-signal intensity (PHSI) on T2WI. Principal component analysis was performed to fuse the texture features to principal components (PCs), and PCs of each sequence of the tumor and peritumoral areas were compared between low- and non-low-grade meningiomas. Only PCs with statistical significance were used for the model construction using a support vector machine algorithm. k-fold cross-validation with receiver operating characteristic curve analysis was used to evaluate diagnostic performance. RESULTS: Two, one, and three PCs of T1WI, apparent diffusion coefficient (ADC), and CE-T1WI, respectively, for the tumor area, were significantly different between low- and non-low-grade meningiomas, while PCs of T2WI for the tumor area and PCs for the peritumoral area were not. No significant differences were observed in PHSI. Among models of sequence combination, the model with PCs of ADC and CE-T1WI for the tumor area showed the highest area under the curve (0.84). CONCLUSION: The model with PCs of ADC and CE-T1WI for the tumor area showed the highest diagnostic performance for differentiating between low- and non-low-grade meningiomas. Neither PHSI nor PCs in the peritumoral area showed added value.

  39. Individualized risk assessment of recanalization of visceral aneurysms using stagnation of intra-aneurysmal flow

    Hiroki Kamada, Masanori Nakamura, Hideki Ota, Sota Oguro, Satoshi Higuchi, Tomomi Sato, Kei Takase

    Journal of Biorheology　37　(2)　73-82　2023

    Publisher: Japanese Society of Biorheology

    DOI： 10.17106/jbr.37.73 　

    ISSN： 1867-0466

    eISSN： 1867-0474

  40. Bipolar Radiofrequency Ablation of the Adrenal Gland: &lt;i&gt;In Vivo&lt;/i&gt; and &lt;i&gt;Ex Vivo&lt;/i&gt; Experiments

    Tomo Kinoshita, Kazumasa Seiji, Sota Oguro, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

    The Tohoku Journal of Experimental Medicine　259　(2)　127-133　2023

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2022.j110 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  41. Clinical impact of cardiac magnetic resonance in patients with suspected coronary artery disease associated with chronic kidney disease (AQUAMARINE-CKD study): study protocol for a randomized controlled trial

    Teruo Noguchi, Hideki Ota, Naoya Matsumoto, Yoshiaki Morita, Akira Oshita, Eiji Kawasaki, Tomohiro Kawasaki, Kensuke Moriwaki, Shingo Kato, Kazuki Fukui, Tomoya Hoshi, Hiroaki Watabe, Tomoaki Kanaya, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Kensuke Takagi, Shuichi Yoneda, Kenichiro Sawada, Takamasa Iwai, Hideo Matama, Satoshi Honda, Masashi Fujino, Hiroyuki Miura, Kunihiro Nishimura, Kei Takase

    Trials　23　(1)　2022/12

    DOI： 10.1186/s13063-022-06820-w 　

    eISSN： 1745-6215

  42. Blood flow analysis with computational fluid dynamics and 4D-flow MRI for vascular diseases. International-journal

    Hiroki Kamada, Masanori Nakamura, Hideki Ota, Satoshi Higuchi, Kei Takase

    Journal of cardiology　80　(5)　386-396　2022/11

    DOI： 10.1016/j.jjcc.2022.05.007 　

    More details Close

    Both computational fluid dynamics (CFD) and time-resolved, three-dimensional, phase-contrast, magnetic resonance imaging (4D-flow MRI) enable visualization of time-varying blood flow structures and quantification of blood flow in vascular diseases. However, they are totally different. CFD is a method to calculate blood flow by solving the governing equations of fluid mechanics, so the obtained flow field is somewhat virtual. On the other hand, 4D-flow MRI measures blood flow in vivo, thus the flow is real. Recently, with the development and enhancement of computers, medical imaging techniques, and related software, blood flow analysis has become more accessible to clinicians and its usefulness in vascular diseases has been demonstrated. In this review, we have outlined the methods and characteristics of CFD and 4D-flow MRI, respectively. We have discussed the differences in the characteristics between both methods; reviewed the milestones achieved by blood flow analysis in various vascular diseases; and discussed the usefulness, challenges, and limitations of blood flow analysis. We have discussed the difficulties and limitations of current blood flow analysis. We have also discussed our views on future directions.

  43. 慢性大動脈解離症例における選択的真腔血管内造影CT検査を用いたAdamkiewicz動脈の同定

    大谷 将之, 伊藤 校輝, 樋口 慧, 板垣 皓大, 武富 龍一, 前田 恵, 鈴木 佑輔, 鈴木 智之, 片平 晋太郎, 高橋 悟朗, 熊谷 紀一郎, 大田 英揮, 高瀬 圭, 齋木 佳克

    日本胸部外科学会定期学術集会　75回　CCPA1-6　2022/10

    Publisher: (一社)日本胸部外科学会

  44. Usefulness of maximum intensity projection images of non-enhanced CT for detection of hyperdense middle cerebral artery sign in acute thromboembolic ischemic stroke

    Sota Oguro, Shunji Mugikura, Hideki Ota, Seiji Bito, Yuta Asami, Wataru Sotome, Yoshiaki Ito, Hideki Kaneko, Kazuyo Suzuki, Nobuya Higuchi, Kei Takase

    Japanese Journal of Radiology　40　(10)　1046-1052　2022/10

    DOI： 10.1007/s11604-022-01289-8 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  45. Usefulness of cardiac magnetic resonance for early detection of cancer therapeutics-related cardiac dysfunction in breast cancer patients. International-journal

    Yosuke Terui, Koichiro Sugimura, Hideki Ota, Hiroshi Tada, Kotaro Nochioka, Haruka Sato, Yuko Katsuta, Junko Fujiwara, Narumi Harada-Shoji, Akiko Sato-Tadano, Yoshiaki Morita, Wenyu Sun, Satoshi Higuchi, Shunsuke Tatebe, Shigefumi Fukui, Saori Miyamichi-Yamamoto, Hideaki Suzuki, Nobuhiro Yaoita, Nobuhiro Kikuchi, Miku Sakota, Satoshi Miyata, Yasuhiko Sakata, Takanori Ishida, Kei Takase, Satoshi Yasuda, Hiroaki Shimokawa

    International journal of cardiology　371　472-479　2022/09/14

    DOI： 10.1016/j.ijcard.2022.09.025 　

    More details Close

    BACKGROUND: Prognosis of breast cancer patients has been improved along with the progress in cancer therapies. However, cancer therapeutics-related cardiac dysfunction (CTRCD) has been an emerging issue. For early detection of CTRCD, we examined whether native T1 mapping and global longitudinal strain (GLS) using cardiac magnetic resonance (CMR) and biomarkers analysis are useful. METHODS: We prospectively enrolled 83 consecutive chemotherapy-naïve female patients with breast cancer (mean age, 56 ± 13 yrs.) between 2017 and 2020. CTRCD was defined based on echocardiography as left ventricular ejection fraction (LVEF) below 53% at any follow-up period with LVEF>10% points decrease from baseline after chemotherapy. To evaluate cardiac function, CMR (at baseline and 6 months), 12‑lead ECG, echocardiography, and biomarkers (at baseline and every 3 months) were evaluated. RESULTS: A total of 164 CMRs were performed in 83 patients. LVEF and GLS were significantly decreased after chemotherapy (LVEF, from 71.2 ± 4.4 to 67.6 ± 5.8%; GLS, from -27.9 ± 3.9 to -24.7 ± 3.5%, respectively, both P < 0.01). Native T1 value also significantly elevated after chemotherapy (from 1283 ± 36 to 1308 ± 39 msec, P < 0.01). Among the 83 patients, 7 (8.4%) developed CTRCD. Of note, native T1 value before chemotherapy was significantly higher in patients with CTRCD than in those without it (1352 ± 29 vs. 1278 ± 30 msec, P < 0.01). The multivariable logistic regression analysis revealed that native T1 value was an independent predictive factor for the development of CTRCD [OR 2.33; 95%CI 1.15-4.75, P = 0.02]. CONCLUSIONS: These results indicate that CMR is useful to detect chemotherapy-related myocardial damage and predict for the development of CTRCD in breast cancer patients.

  46. Safety and feasibility of radiofrequency ablation using bipolar electrodes for aldosterone-producing adenoma: a multicentric prospective clinical study. International-journal

    Sota Oguro, Ryo Morimoto, Kazumasa Seiji, Hideki Ota, Tomo Kinoshita, Masahiro Kawabata, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Fumitoshi Satoh, Sadayoshi Ito, Nobukazu Moriya, Seishi Matsui, Tetsuo Nishikawa, Masao Omura, Kazuki Nakai, Seishi Nakatsuka, Isao Kurihara, Kazutoshi Miyashita, Wataru Koda, Tetsuya Minami, Yoshiyu Takeda, Mitsuhiro Kometani, Yutaka Oki, Toshihiro Oishi, Takasuke Ushio, Satoshi Goshima, Kei Takase

    Scientific reports　12　(1)　14090-14090　2022/08/18

    DOI： 10.1038/s41598-022-18136-5 　

    More details Close

    Evaluation of feasibility and safety of percutaneous radiofrequency ablation using bipolar radiofrequency devices in a prospective multicenter cohort of patients with benign aldosterone-producing adenoma. A total of five institutions participated. CT-guided percutaneous RFA was performed for patients diagnosed as APA. The safety of the procedure was evaluated using the Common Terminology Criteria for Adverse Events. During the 84-day follow-up period, serial changes in plasma aldosterone concentration and plasma renin activity were measured. The percentage of patients with normalized hormonal activity after the procedure, was calculated with 95% confidence intervals. Forty patients were enrolled, and two patients were excluded for cerebral hemorrhage and no safe puncture root. In another patients, RFA was tried, but an intraprocedural intercostal arterial injury occurred. Consequently, RFA was completed in thirty-seven patients (20 men, 17 women; mean age, 50.4 ± 10.0 year). The tumor size was 14.8 ± 3.8 mm. The treatment success rate of the ablation was 94.6% (35/37), and a 2nd session was performed in 2.7% (1/37) patients. Grade 4 adverse events were observed in 4 out of 38 sessions (10.5%). The normalization of plasma aldosterone concentration or aldosterone-renin ratio was 86.5% (72.0-94.1: 95% confidence interval) on day 84. Percutaneous CT-guided RFA for APA using a bipolar radiofrequency system was safe and feasible with clinical success rate of 86.5% on day 84.

  47. Transvenous Radiofrequency Ablation of Adrenal Gland: Experimental Study. International-journal

    Hiroyuki Sakakibara, Kazumasa Seiji, Sota Oguro, Kenji Mori, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Takuya Masuda, Hisao Miyamoto, Takuya Hirao, Yuki Niwa, Yohei Suzuki, Yasutaka Baba, Fumitoshi Satoh, Kei Takase

    Cardiovascular and interventional radiology　45　(8)　1178-1185　2022/08

    DOI： 10.1007/s00270-022-03155-6 　

    More details Close

    PURPOSE: The aim was to evaluate a flexible device for transvenous adrenal gland radiofrequency ablation in vitro and in an in vivo animal model. MATERIALS AND METHODS: A flexible radiofrequency-tip catheter with an inner-cooling mechanism and a guidewire lumen was made. Then, using a polyvinyl alcohol gel model, the ablation diameter was evaluated and how much energy to deliver in vivo was determined. Finally, transvenous radiofrequency ablation of the left adrenal glands of two pigs was performed, delivering 5000 or 7000 J in a single dose to each. The ablation effects were also assessed by histological examination of hematoxylin-eosin-stained sections. RESULTS: The mean ablation diameters in the gel model were 20.2 and 21.9 mm in the short axis and 15 and 20 mm in the long axis for 5000 or 7000 J, respectively. The device was inserted into porcine left adrenal vein with no complications. The mean ablation diameters were 10 mm in the shorter axis (whole thickness of porcine left adrenal gland) in the porcine model for 7000 J. Transient increases in blood pressure and heart rate occurred during ablation. Histologically, the adrenal gland showed severe necrosis at ablated area. There was venous congestion upstream in a non-ablated area, and thermal damage to surrounding organs was not observed. CONCLUSIONS: A flexible radiofrequency-tip catheter could be inserted successfully into the left adrenal vein. The left adrenal gland was entirely ablated without any thermal damage to surrounding organs. We suggest transvenous adrenal ablation has potential as a therapeutic option for primary aldosteronism.

  48. 【アルドステロンをめぐる臨床課題】原発性アルドステロン症治療におけるラジオ波治療の意義

    柳垣 聡, 小黒 草太, 清治 和将, 高瀬 圭, 尾股 慧, 手塚 雄太, 小野 美澄, 森本 玲, 田中 哲洋, 佐藤 文俊

    糖尿病・内分泌代謝科　55　(2)　204-209　2022/08

    Publisher: (有)科学評論社

    ISSN： 2435-1946

  49. Multimodal imaging findings including high-resolution 3D T2-weighted imaging for COVID-19 vaccine-associated axillary lymphadenopathy in a patient with breast cancer

    Hiroaki Shimizu, Naoko Mori, Hainan Ren, Minoru Miyashita, Satoko Sato, Shunji Mugikura, Kei Takase

    Radiology Case Reports　17　(8)　2831-2836　2022/08

    DOI： 10.1016/j.radcr.2022.04.044 　

    eISSN： 1930-0433

  50. Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging

    Naoko Mori, Chihiro Inoue, Hajime Tamura, Tatsuo Nagasaka, Hainan Ren, Satoko Sato, Yu Mori, Minoru Miyashita, Shunji Mugikura, Kei Takase

    Magnetic Resonance Imaging　90　53-60　2022/07

    DOI： 10.1016/j.mri.2022.04.003 　

    ISSN： 0730-725X

    eISSN： 1873-5894

  51. Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment

    Simon Tupin, Kei Takase, Makoto Ohta

    Fluids　7　(7)　220-220　2022/06/30

    Publisher: MDPI AG

    DOI： 10.3390/fluids7070220 　

    eISSN： 2311-5521

    More details Close

    Decades after its introduction, endovascular aneurysm repair remains a challenging procedure with risks of collateral patency failure. Here, we investigate the ability of a porous stent, the Multilayer Flow Modulator (MFM), to maintain renal perfusion after a single or overlapping case. Silicone models representing an ideal infrarenal AAA geometry were used to analyze and compare three cases (control, single MFM and two overlapped MFMs). Micro-computed tomography was used to image the deployed MFM devices geometry and evaluate pore size and density along with porosity in both two (planimetric) and three dimensions (gravimetric). Laser particle image velocimetry (PIV) experiments were performed to image velocity and vorticity fields at the aorta-renal bifurcation. Flow experiments revealed renal arteries perfusion preservation in both single and overlapped cases. Microstructure analysis revealed an uneven distribution of wires in the MFM devices leading to local change in planimetric porosity and pore size. Overlap of a second MFM device led to a significant decrease in those 2D metrics but did not affect the gravimetric porosity and the branch perfusion. This first microstructure evaluation of MFM device combined with flow experiments revealed the ability of the device to preserve collateral flow thanks to a highly porous microstructure.

  52. The role of magnetic resonance imaging in prostate cancer patients on active surveillance

    Naoko Mori, Shunji Mugikura, Kei Takase

    The British Journal of Radiology　96　(1151)　20220140　2022/05/23

    DOI： 10.1259/bjr.20220140 　

    eISSN： 1748-880X

  53. Update on the roles of imaging in the management of chronic thromboembolic pulmonary hypertension. International-journal

    Satoshi Higuchi, Hideki Ota, Nobuhiro Yaoita, Hiroki Kamada, Hidenobu Takagi, Taiju Sato, Satoshi Yasuda, Kei Takase

    Journal of cardiology　81　(3)　297-306　2022/04/27

    DOI： 10.1016/j.jjcc.2022.03.001 　

    More details Close

    Chronic thromboembolic pulmonary hypertension (CTEPH), classified as group 4 pulmonary hypertension (PH), is caused by stenosis and obstruction of the pulmonary arteries by organized thrombi that are incompletely resolved after acute pulmonary embolism. The prognosis of patients with CTEPH is poor if untreated; however, in expert centers with multidisciplinary teams, a treatment strategy for CTEPH has been established, dramatically improving its prognosis. CTEPH is currently not a fatal disease and is the only curable form of PH. Despite these advances and the establishment of treatment approaches, early diagnosis is still challenging, especially for non-experts, for several reasons. One of the reasons for this is insufficient knowledge of the various diagnostic imaging modalities, which are essential in the clinical practice of CTEPH. Imaging modalities should detect the following pathological findings: lung perfusion defects, thromboembolic lesions in pulmonary arteries, and right ventricular remodeling and dysfunction. Perfusion lung scintigraphy and catheter angiography have long been considered gold standards for the detection of perfusion defects and assessment of vascular lesions, respectively. However, advances in imaging technology of computed tomography and magnetic resonance imaging have enabled the non-invasive detection of these abnormal findings in a single examination. Cardiac magnetic resonance (CMR) is the gold standard for evaluating the morphology and function of the right heart; however, state-of-the-art techniques in CMR allow the assessment of cardiac tissue characterization and hemodynamics in the pulmonary arteries. Comprehensive knowledge of the role of imaging in CTEPH enables appropriate use of imaging modalities and accurate image interpretation, resulting in early diagnosis, determination of treatment strategies, and appropriate evaluation of treatment efficacy. This review summarizes the current roles of imaging in the clinical practice for CTEPH, demonstrating the characteristic findings observed in each modality.

  54. 新規測定法によるアルドステロン症診断と高血圧症診療の精緻化

    佐藤 文俊, 小野 美澄, 手塚 雄太, 尾股 慧, 山崎 有人, 森本 玲, 高瀬 圭, 田中 哲洋, 笹野 公伸, 小島 哲

    日本内分泌学会雑誌　98　(1)　214-214　2022/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  55. Clinical Application of 4D Flow MR Imaging to Pulmonary Hypertension.

    Hideki Ota, Hiroki Kamada, Satoshi Higuchi, Kei Takase

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　21　(2)　309-318　2022/03/01

    DOI： 10.2463/mrms.rev.2021-0111 　

    More details Close

    Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure (PAP). Although right-heart catheterization is the gold standard method for the diagnosis of PH by definition, various less-invasive imaging tests have been used for screening, detection of underlying diseases-causing PH, and monitoring of diseases. Among them, 4D flow MRI is an emerging and unique imaging test that allows for comprehensive visualization of blood flow in the right heart and proximal pulmonary arteries. The characteristic blood flow pattern observed in patients with PH is vortical flow formation in the main pulmonary artery. Recent studies have proposed the use of these findings to determine not only the presence of PH but also estimate the mean PAP. Other applications of 4D flow MRI for PH include measurement of wall shear stress, helicity, and 3D flow balance in the pulmonary arteries. It is worth noting that 4D flow has also the potential for longitudinal follow-ups. In this review, the clinical definition of PH, summary of conventional imaging tests, characteristics of pulmonary arterial flow as shown by 4D flow MRI, and clinical application of 4D flow MRI in the management of patients with PH will be discussed.

  56. Novel technique for recanalization of severe hepaticojejunal obstruction using a transseptal needle in a pediatric liver transplant recipient

    Kengo Sasaki, Hideki Ota, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Yoshikatsu Saitoh, Norifumi Kanai, Hiroyasu Nishimaki, Kei Takase, Michiaki Unno, Takashi Kamei

    Pediatric Transplantation　26　(2)　2022/03

    DOI： 10.1111/petr.14160 　

    ISSN： 1397-3142

    eISSN： 1399-3046

  57. Quantification of vortex flow in pulmonary arteries of patients with chronic thromboembolic pulmonary hypertension

    Hiroki Kamada, Hideki Ota, Masanori Nakamura, Wenyu Sun, Tatsuo Aoki, Haruka Sato, Koichiro Sugimura, Kei Takase

    European Journal of Radiology　148　2022/03

    DOI： 10.1016/j.ejrad.2021.110142 　

    ISSN： 0720-048X

    eISSN： 1872-7727

  58. Grading of placental accrete spectrum using texture analysis of magnetic resonance imaging. International-journal

    Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

    Clinical imaging　85　8-9　2022/02/22

    DOI： 10.1016/j.clinimag.2022.02.018 　

  59. 関節リウマチ薬物治療効果判定に有効な手関節ダイナミックMRIのパラメータ検証

    森 菜緒子, 常陸 真, 麦倉 俊司, 高瀬 圭, 森 優, 井上 麻美

    Japanese Journal of Radiology　40　(Suppl.)　5-5　2022/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  60. Letter to the editor on "High signal intensity on diffusion-weighted magnetic resonance images is a useful finding for detecting early-stage pancreatic cancer". International-journal

    Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

    Abdominal radiology (New York)　47　(2)　905-906　2022/02

    DOI： 10.1007/s00261-021-03346-8 　

  61. Extra- or Peritumoral Hyperintensity on T2-weighted Images in Patients with Breast Cancer. International-journal

    Naoko Mori, Shunji Mugikura, Kei Takase

    Radiology　302　(2)　E7-E8　2022/02

    DOI： 10.1148/radiol.2021210939 　

  62. Longitudinal evaluation of apparent diffusion coefficient values as a predictor of Prostate Cancer Research International Active Surveillance reclassification. International-journal

    Eri Ota, Naoko Mori, Shinichi Yamashita, Shunji Mugikura, Akihiro Ito, Kei Takase

    Abdominal radiology (New York)　47　(2)　814-826　2022/02

    DOI： 10.1007/s00261-021-03372-6 　

    More details Close

    PURPOSE: This study aimed to evaluate the effectiveness of apparent diffusion coefficient (ADC) parameters in distinguishing between Prostate Cancer Research International Active Surveillance (PRIAS) non-reclassification and reclassification groups during active surveillance (AS) of prostate cancer. METHODS: We included 55 patients who fulfilled the PRIAS criteria and underwent ≥ 2 magnetic resonance imaging (MRI) including diffusion-weighted imaging with an interval of ≤ 3 years between baseline and second MRI. A mono-exponential fitting model was used to automatically create ADC maps with minimum b-values of 0 and maximum of 2000 s/mm2. For detectable lesions on ADC maps, the lesions were manually segmented on each slice of the ADC maps. For undetectable lesions, the corresponding normal-appearing zone of the lobe on each slice of ADC maps was segmented. The ADC data for each slice were summed to obtain the 25th, 50th, and 75th percentile ADC values of the histogram at baseline and second MRI. These ADC parameters at baseline and second MRI, and the changes of ADC parameters from baseline to second MRI were compared between PRIAS non-reclassification and reclassification groups. RESULTS: The PRIAS reclassification group had significantly lower 25th, 50th, and 75th percentile ADC values at second MRI compared to the non-reclassification group. The non-reclassification group had significantly lower changes in ADC values in these percentiles compared to the reclassification group. CONCLUSION: The ADC parameters at second MRI and the changes from baseline to second MRI may be effective distinguishing factors between PRIAS non-reclassification and reclassification groups.

  63. Application of cumulative summation (CUSUM) method and mathematical model to evaluate the learning effect in central venous catheter port implantation.

    Naoko Mori, Hiroaki Shimizu, Shunji Mugikura, Kei Takase

    Japanese journal of radiology　2022/01/22

    DOI： 10.1007/s11604-021-01242-1 　

  64. Quantitative assessment of microstructural evolution of intracranial aneurysm wall by vessel wall imaging. International-journal

    Hidenori Endo, Naoko Mori, Shunji Mugikura, Kuniyasu Niizuma, Shunsuke Omodaka, Kei Takase, Teiji Tominaga

    Neuroradiology　64　(7)　1343-1350　2022/01/08

    DOI： 10.1007/s00234-021-02877-7 　

    More details Close

    PURPOSE: This study aimed to evaluate new quantitative parameters of aneurysm wall enhancement (AWE) on magnetic resonance vessel wall imaging (VWI) in differentiating between the stable and evolving unruptured intracranial aneurysms (UIAs). METHODS: Thirty-eight consecutive patients with UIAs (27 stable and 11 evolving) underwent VWI with contrast-enhanced 3D T1 volume isotropic turbo spin echo acquisition. The voxel-based enhancement maps were created using pre- and post-contrast images. The aneurysmal lumen with signal suppression by black-blood method was segmented. Then, one voxel outer and inner layers of the lumen contour were automatically segmented. The shape features of the aneurysms and AWE of the two layers were compared between stable and evolving groups. RESULTS: The shape features, including aneurysm volume, surface, and compacity were significantly different between the stable and evolving groups (P = 0.024, 0.028, and 0.033, respectively). Stable and evolving groups also differed significantly in the AWE at the union of outer and inner layers of the aneurysm wall (P = 0.0082) but not in that of the outer or inner layer alone. Multivariate logistic regression analysis revealed significant differences in aneurysm volume, surface, and AWE at the union of outer and inner layers between the two groups (P = 0.0029, 0.0092, and 0.0033, respectively). Receiver operating characteristics curve analysis revealed that the area under the curve of the logistic regression model was 0.89. CONCLUSION: Quantitative combined analysis of aneurysm shape features and AWE of the union of outer and inner layers were effective for differentiating between stable and evolving UIAs.

  65. Prediction of the development of delirium after transcatheter aortic valve implantation using preoperative brain perfusion SPECT. International-journal

    Masashi Takeuchi, Hideaki Suzuki, Yasuharu Matsumoto, Yoku Kikuchi, Kentaro Takanami, Toshihiro Wagatsuma, Jun Sugisawa, Satoshi Tsuchiya, Kensuke Nishimiya, Kiyotaka Hao, Shigeo Godo, Tomohiko Shindo, Takashi Shiroto, Jun Takahashi, Kiichiro Kumagai, Masahiro Kohzuki, Kei Takase, Yoshikatsu Saiki, Satoshi Yasuda, Hiroaki Shimokawa

    PloS one　17　(11)　e0276447　2022

    DOI： 10.1371/journal.pone.0276447 　

    More details Close

    OBJECTIVES: Delirium is an important prognostic factor in postoperative patients undergoing cardiovascular surgery and intervention, including transcatheter aortic valve implantation (TAVI). However, delirium after transcatheter aortic valve implantation (DAT) is difficult to predict and its pathophysiology is still unclear. We aimed to investigate whether preoperative cerebral blood flow (CBF) is associated with DAT and, if so, whether CBF measurement is useful for predicting DAT. METHODS: We evaluated CBF in 50 consecutive patients before TAVI (84.7±4.5 yrs., 36 females) using 99mTc ethyl cysteinate dimer single-photon emission computed tomography. Preoperative CBF of the DAT group (N = 12) was compared with that of the non-DAT group (N = 38) using whole brain voxel-wise analysis with SPM12 and region of interest-based analysis with the easy-Z score imaging system. Multivariable logistic regression analysis with the presence of DAT was used to create its prediction model. RESULTS: The whole brain analysis showed that preoperative CBF in the insula was lower in the DAT than in the non-DAT group (P<0.05, family-wise error correction). Decrease extent ratio in the insula of the DAT group (17.6±11.5%) was also greater relative to that of the non-DAT group (7.0±11.3%) in the region of interest-based analysis (P = 0.007). A model that included preoperative CBF in the insula and conventional indicators (frailty index, short physical performance battery and mini-mental state examination) showed the best predictive power for DAT (AUC 0.882). CONCLUSIONS: These results suggest that preoperative CBF in the insula is associated with DAT and may be useful for its prediction.

  66. Systemic-pulmonary collateral supply associated with clinical severity of chronic thromboembolic pulmonary hypertension: a study using intra-aortic computed tomography angiography

    Wenyu Sun, Hideki Ota, Haruka Sato, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Koichiro Sugimura, Junya Tominaga, Hiroaki Shimokawa, Takuya Ueda, Kei Takase

    European Radiology　32　(11)　7668-7679　2022

    DOI： 10.1007/s00330-022-08768-6 　

    ISSN： 0938-7994

    eISSN： 1432-1084

  67. Significance of systolic-phase imaging on full-phase ECG-gated CT angiography to detect intimal tears in aortic dissection

    Satoru Yanagaki, Atsuro Masuda, Hideki Ota, Masatoshi Kojima, Takashi Hattori, Wahei Mihara, Kei Takase, Takuya Ueda

    Heart and Vessels　37　(11)　1947-1956　2022

    DOI： 10.1007/s00380-022-02093-0 　

    ISSN： 0910-8327

    eISSN： 1615-2573

  68. Clinical assessment of efficacy of poly-L-lactide sternal pin on sternal stability and post-operative pain: a prospective randomized trial in cardiovascular surgery. International-journal

    Shingo Takahara, Konosuke Sasaki, Takeshi Saito, Kei Sakuma, Hidenori Fujiwara, Ichiro Yoshioka, Kiichiro Kumagai, Wenyu Sun, Kei Takase, Yoshikatsu Saiki

    Journal of thoracic disease　14　(1)　76-89　2022/01

    DOI： 10.21037/jtd-21-1340 　

    More details Close

    BACKGROUND: Although the incident rate is low, sternal dislocation and dehiscence due to unstable sternal fixation after cardiovascular surgery could cause potentially lethal complications. Thus, to enforce the stability of closed sternum, the sternal pins have been utilized at surgeon's discretion. However, there is no randomized clinical trial to test whether these pins are effective to stabilize a sternum. Hence, this study aimed to examine the clinical efficacy of bioabsorbable poly-L-lactide (PLLA) sternal pins in reinforcing sternal stability and preventing instability of the sternum after full sternotomy. METHODS: We conducted a single institutional, prospective, randomized, single-blinded clinical study involving 100 patients who underwent an initial cardiovascular surgery via sternotomy. Patients were randomly allocated into two groups: with (group P) and without (group N) PLLA sternal pins, at 1:1 ratio from November 2013 to April 2016. Sternal deviation and stability were assessed with postoperative computed tomography (CT) at two postures to put shear stress on the sternum. Additionally, information on patient demographic indices was obtained prospectively, and patient's pain intensity was assessed with numerical rating scoring system during rehabilitation. Furthermore, propensity score matching was performed for further comparative sub-analysis. RESULTS: Ninety-one patients (43 in group P and 48 in group N) were analyzed using the intention-to-treat method. Group N had a significantly higher proportion of males (P=0.015) and ischemic disease as a primary diagnosis (P=0.040) than group P. Postoperative CT showed that the degree of sternal deviation and stability were comparable between the groups. Similarly, the numerical rating score of pain during rehabilitation showed no difference between the groups. Even after adjusting for patient characteristics using propensity score matching method, no significant differences in sternal gaps, stability, and numerical rating score of pain were observed. Of note, no material-related adverse event such as wound infection was found. CONCLUSIONS: We could not identify the efficacy of the sternal pin in enforcing sternal stability based on CT measurements with mild shear stress on sternum after cardiovascular surgery. Nevertheless, our results with no adverse events might encourage further investigations with a more specific cohort who is susceptible to infection but requires an additional sternal fixation. TRIAL REGISTRATION: This study was registered in University Hospital Medical Information Network Clinical Trial Registry (UMIN000017357).

  69. Reversible increase in stress-associated neurobiological activity in the acute phase of Takotsubo syndrome; a brain 18F-FDG-PET study. International-journal

    Hideaki Suzuki, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa, Satoshi Yasuda

    International journal of cardiology　344　31-33　2021/12/01

    DOI： 10.1016/j.ijcard.2021.09.057 　

    More details Close

    INTRODUCTION: Takotsubo syndrome (TTS) is triggered mostly by physical and/or emotional stress that is processed in stress-associated brain regions, including the amygdala. However, it remains unclear whether such stress-induced brain activity is associated with TTS onset. METHODS AND RESULTS: We acquired brain [18F]-2-fluoro-deoxy-d-glucose (18F-FDG) positron emission tomography in 4 TTS patients (44-82 yrs., 3 women) on days 2-4 (acute phase) and days 29-40 (recovery phase) after diagnosis of TTS was made by coronary angiography and left ventriculogram. The 18F-FDG uptake was measured globally and also in the pre-defined regions of interest of the bilateral amygdala on the common Montreal Neurological Institute space; all 18F-FDG images were normalized using automated image pre-processing. Amygdalar activity was calculated by dividing the 18F-FDG uptake of the amygdala by the global brain uptake. Left ventriculograms showed that apical ballooning was typical at diagnosis and was then relieved in the recovery phase. Amygdalar activity in the acute phase (0.872 ± 0.032) was higher than in the recovery phase (0.805 ± 0.037) (P = 0.013). CONCLUSIONS: We report here 4 cases of TTS showing higher amygdalar activity in the acute phase as compared with the recovery phase, suggesting that increased stress-induced neurobiological activity is associated with TTS onset.

  70. Fibromuscular dysplasia with recurrence after “long-term” following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients

    Shuntaro Oribe, Takafumi Toyohara, Eikan Mishima, Takehiro Suzuki, Koichi Kikuchi, Shun Watanabe, Yoshiaki Morita, Hideki Ota, Kazumasa Seiji, Mariko Miyazaki, Kei Takase, Takaaki Abe

    BMC Nephrology　22　(1)　2021/12

    DOI： 10.1186/s12882-021-02342-w 　

    eISSN： 1471-2369

  71. Carotid computed tomography angiography after cobalt-based alloy carotid artery stenting using ultra-high-resolution computed tomography with model-based iterative reconstruction

    Shingo Kayano, Hideki Ota, Yoshimichi Sato, Toshiki Endo, Kuniyasu Niizuma, Ichiro Suzuki, Tsuyoshi Kawamura, Kei Takase

    Radiology Case Reports　16　(12)　3721-3728　2021/12

    DOI： 10.1016/j.radcr.2021.09.003 　

    eISSN： 1930-0433

  72. Importance of ADC parameters from histogram analysis corresponding to histological components in endometrial cancer. International-journal

    Naoko Mori, Shunji Mugikura, Kei Takase

    European journal of radiology　144　110004-110004　2021/11

    DOI： 10.1016/j.ejrad.2021.110004 　

  73. Prediction of placenta accreta spectrum using texture analysis on coronal and sagittal T2-weighted imaging. International-journal

    Hainan Ren, Naoko Mori, Shunji Mugikura, Hiroaki Shimizu, Sakiko Kageyama, Masatoshi Saito, Kei Takase

    Abdominal radiology (New York)　46　(11)　5344-5352　2021/11

    DOI： 10.1007/s00261-021-03226-1 　

    More details Close

    PURPOSE: To separately perform visual and texture analyses of the axial, coronal, and sagittal planes of T2-weighted images and identify the optimal method for differentiating between the normal placenta and placenta accreta spectrum (PAS). METHODS: Eighty consecutive patients (normal group, n = 50; PAS group, n = 30) underwent preoperative MRI. A scoring system (0-2) was used to evaluate the degree of abnormality observed in visual analysis (bulging, abnormal vascularity, T2 dark band, placental heterogeneity). The axial, coronal, and sagittal planes were manually segmented separately to obtain texture features, and seven combinations were obtained: axial; coronal; sagittal; axial and coronal; axial and sagittal; coronal and sagittal; and axial, coronal, and sagittal. Feature selection using the least absolute shrinkage and selection operator method and model construction using a support vector machine algorithm with k-fold cross-validation were performed. AUC was used to evaluate diagnostic performance. RESULTS: The AUC of visual analysis was 0.75. The model 'coronal and sagittal' had the highest AUC (0.98) amongst the seven combinations. The fivefold cross-validation for the model 'coronal and sagittal' showed AUCs of 0.85 and 0.97 in training and validation sets, respectively. The AUC of the model 'coronal and sagittal' for all subjects was significantly higher than that of visual analysis (0.98 vs. 0.75; p < 0.0001). CONCLUSION: The model 'coronal and sagittal' can accurately differentiate between the normal placenta and PAS, with a significantly better diagnostic performance than visual analysis. Texture analysis is an optimal method for differentiating between the normal placenta and PAS.

  74. アルドステロン産生腺腫における18-oxocortisol産生機序の解明

    手塚 雄太, 山崎 有人, 尾股 慧, 小野 美澄, 森本 玲, 高瀬 圭, 川崎 芳英, 伊藤 明宏, 西川 潤, 朝井 典子, Gomez-Sanchez Celso E., 伊藤 貞嘉, 出澤 真里, 笹野 公伸, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　43回　219-219　2021/10

    Publisher: (NPO)日本高血圧学会

  75. 片側性原発性アルドステロン症の発症経過を捉え得た若年性高血圧症の一例

    手塚 雄太, 小野 美澄, 山崎 有人, 樋口 慧, 尾股 慧, 森本 玲, 大田 英揮, 川崎 芳英, 高瀬 圭, 伊藤 明宏, 笹野 公伸, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　43回　281-281　2021/10

    Publisher: (NPO)日本高血圧学会

  76. Indication of perfusion contrast-enhanced ultrasound for diagnosing lymph nodes.

    Naoko Mori, Shunji Mugikura, Kei Takase

    Japanese journal of radiology　39　(10)　1017-1018　2021/10

    DOI： 10.1007/s11604-021-01160-2 　

  77. Utility of histogram analysis for apparent diffusion coefficient values in evaluating the pathological characteristics of endometrial cancer. International-journal

    Naoko Mori, Shunji Mugikura, Kei Takase

    The British journal of radiology　20210928-20210928　2021/09/14

    DOI： 10.1259/bjr.20210928 　

  78. Cholangiojejunostomy assisted by techniques of interventional radiology for a patient with recurrent jaundice after Kasai portoenterostomy

    Ryuji Okubo, Hideyuki Sasaki, Hideki Ota, Motoshi Wada, Taichi Fukuzawa, Hironori Kudo, Ryo Ando, Yuki Endo, Masatoshi Hashimoto, Kosuke Sato, Kei Takase, Masaki Nio

    Journal of Pediatric Surgery Case Reports　72　2021/09

    DOI： 10.1016/j.epsc.2021.101961 　

    eISSN： 2213-5766

  79. Pancreatic foregut cystic malformation with a bifid pancreatic tail

    Yuki Endo, Motoshi Wada, Hideyuki Sasaki, Taichi Fukuzawa, Hironori Kudo, Ryo Ando, Satoshi Yamaki, Ryuji Okubo, Masatoshi Hashimoto, Yudai Nakajima, Kosuke Sato, Hidekazu Aoki, Hideki Ota, Kei Takase, Masaki Nio

    Journal of Pediatric Surgery Case Reports　72　101963-101963　2021/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.epsc.2021.101963 　

    ISSN： 2213-5766

  80. Experimental Analysis of Pressure and Flow Alterations During and After Insertion of a Multilayer Flow Modulator into an AAA Model with Incorporated Branch. International-journal

    Simon Tupin, Kei Takase, Makoto Ohta

    Cardiovascular and interventional radiology　44　(8)　1251-1259　2021/08

    DOI： 10.1007/s00270-021-02835-z 　

    More details Close

    PURPOSE: The multilayer flow modulator (MFM) device has been used for the treatment of abdominal aortic aneurysm (AAA) for over a decade. Although several clinical studies have been published, criticism and concern over the device efficacy remain, as no quantitative analysis that describes its mechanism has been performed yet. The aim of this study was to experimentally evaluate the effect of MFM device deployment on aneurysmal pressure and branch perfusion. MATERIALS AND METHODS: An experimental flow and pressure monitoring system was developed to analyze the MFM deployment procedure performed by a qualified radiologist in AAA geometries with and without side branch. Particle image velocimetry experiments were then conducted on models with and without MFM device to evaluate and compare flow patterns and local flow velocity and vorticity in the aneurysm. RESULTS: The experiments revealed no significant change in pressure and flow rate during and after deployment of the MFM device. The flow rate of the incorporated branch was fully preserved. On both models, the aneurysmal flow velocity was significantly reduced. In addition, the device modified local flow patterns, reducing vorticity and better feeding the incorporated branch. CONCLUSION: This experimental study provides the basis for a better understanding of the mechanism of the MFM device, which allows intra-aneurysmal flow to decrease while preserving incorporated branch flow and reducing the risk of type II endoleak. The experimental system developed for this study was effective in simulating an endovascular procedure and studying the safety and effectiveness of endovascular devices.

  81. Mathematical model for histogram analysis of dynamic contrast-enhanced MRI: A method to evaluate the drug treatment response in rheumatoid arthritis

    Yu Mori, Naoko Mori, Takuya Izumiyama, Asami Inoue, Kei Takase, Toshimi Aizawa

    European Journal of Radiology　141　109831-109831　2021/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.ejrad.2021.109831 　

    ISSN： 0720-048X

  82. Efficacy of cell proliferation imaging with 4DST PET/CT for predicting the prognosis of patients with esophageal cancer: a comparison study with FDG PET/CT

    Masatoshi Hotta, Ryogo Minamimoto, Jun Toyohara, Kyoko Nohara, Kazuhiko Nakajima, Kei Takase, Kazuhiko Yamada

    European Journal of Nuclear Medicine and Molecular Imaging　48　(8)　2615-2623　2021/07

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00259-020-05179-x 　

    ISSN： 1619-7070

    eISSN： 1619-7089

  83. Assessment of the sequential time–signal enhancement curve of dynamic contrast-enhanced MRI might be effective in diagnosing growth hormone-producing pituitary adenomas

    Naoko Mori, Shunji Mugikura, Kei Takase

    Japanese Journal of Radiology　2021/06/04

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11604-021-01146-0 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  84. 葛西手術後長期経過後の肝門部再閉塞に対してIVRが有用であった1例

    田中 拡, 大田 英揮, 佐々木 英之, 佐野 信行, 北見 昌広, 齋藤 美穂子, 和田 基, 福澤 太一, 中村 恵美, 工藤 博典, 安藤 亮, 山木 聡史, 大久保 龍二, 高瀬 圭, 仁尾 正記

    日本小児外科学会雑誌　57　(4)　791-791　2021/06

    Publisher: (一社)日本小児外科学会

    ISSN： 0288-609X

    eISSN： 2187-4247

  85. Ultrashort echo time time-spatial labeling inversion pulse magnetic resonance angiography with denoising deep learning reconstruction for the assessment of abdominal visceral arteries

    Ryuichi Mori, Yoshimori Kassai, Atsuro Masuda, Yoshiaki Morita, Tomoyoshi Kimura, Tatsuo Nagasaka, Takashi Nishina, Sho Tanaka, Mitsue Miyazaki, Kei Takase, Hideki Ota

    Journal of Magnetic Resonance Imaging　53　(6)　1926-1937　2021/06

    DOI： 10.1002/jmri.27481 　

    ISSN： 1053-1807

    eISSN： 1522-2586

  86. 【皮膚悪性腫瘍(第2版)上-基礎と臨床の最新研究動向-】メラノーマ メラノーマの検査・診断 画像診断 CT、MRI

    木下 知, 森下 陽平, 高瀬 圭

    日本臨床　79　(増刊2 皮膚悪性腫瘍(上))　225-228　2021/05

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  87. Discriminating low-grade ductal carcinoma in situ (DCIS) from non-low-grade DCIS or DCIS upgraded to invasive carcinoma: effective texture features on ultrafast dynamic contrast-enhanced magnetic resonance imaging

    Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yo Oguma, Minami Hirasawa, Satoko Sato, Kei Takase

    Breast Cancer　2021/04/26

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12282-021-01257-6 　

    ISSN： 1340-6868

    eISSN： 1880-4233

  88. Beneficial effects of exercise training on physical performance in patients with vasospastic angina. International-journal

    Jun Sugisawa, Yasuharu Matsumoto, Masashi Takeuchi, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Ohura, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

    International journal of cardiology　328　14-21　2021/04/01

    DOI： 10.1016/j.ijcard.2020.12.003 　

    More details Close

    AIMS: In vasospastic angina (VSA), coronary vasomotion abnormalities could develop not only in epicardial coronary arteries but also in coronary microvessels, where calcium channel blockers (CCBs) have limited efficacy. However, efficacy of exercise training for VSA remains to be elucidated. We thus aimed to examine whether vasodilator capacity of coronary microvessels is impaired in VSA patients, and if so, whether exercise exerts beneficial effects on the top of CCBs. METHODS: We performed 2 clinical protocols. In the protocol 1, we measured myocardial blood flow (MBF) using adenosine-stress dynamic computed tomography perfusion (CTP) in 38 consecutive VSA patients and 17 non-VSA controls. In the protocol 2, we conducted randomized controlled trial, where 20 VSA patients were randomly assigned to either 3-month exercise training group (Exercise group) or Non-Exercise group (n= 10 each). RESULTS: In the protocol 1, MBF on CTP was significantly decreased in the VSA group compared with the Non-VSA group (138 ± 6 vs 166 ± 10 ml/100 g/min, P = 0.02). In the protocol 2, exercise capacity was significantly increased in the Exercise group than in the Non-Exercise group (11.5 ± 0.5 to 15.4 ± 1.8 vs 12.6 ± 0.7 to 14.0 ± 0.8 ml/min/kg, P < 0.01). MBF was also significantly improved after 3 months only in the Exercise group (Exercise group, 145 ± 12 to 172 ± 8 ml/100 g/min, P < 0.04; Non-Exercise group, 143 ± 14 to 167 ± 8 ml/100 g/min, P = 0.11), although there were no significant between-group differences. CONCLUSIONS: These results provide the first evidence that, in VSA patients, exercise training on the top of CCBs treatment may be useful to improve physical performance, although its effect on MBF may be minimal.

  89. Value of ultrafast and standard dynamic contrast-enhanced magnetic resonance imaging in the evaluation of the presence and extension of residual disease after neoadjuvant chemotherapy in breast cancer

    Erina Kato, Naoko Mori, Shunji Mugikura, Satoko Sato, Takanori Ishida, Kei Takase

    Japanese Journal of Radiology　2021/03/20

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11604-021-01110-y 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  90. Usefulness of Native T1 Mapping for Prediction of Chemotherapeutics-related Cardiac Dysfunction in Breast Cancer Patients(和訳中)

    照井 洋輔, 杉村 宏一郎, 大田 英揮, 多田 寛, 勝田 祐子, 佐藤 遥, 後岡 広太郎, 建部 俊介, 宮田 敏, 坂田 泰彦, 石田 孝宜, 高瀬 圭, 安田 聡

    日本循環器学会学術集会抄録集　85回　OJ29-5　2021/03

    Publisher: (一社)日本循環器学会

  91. Correction to: Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. International-journal

    Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase

    European radiology　31　(3)　1780-1781　2021/03

    DOI： 10.1007/s00330-020-07144-6 　

  92. The Potential of Computed Tomography Volumetry for the Surgical Treatment in Bilateral Macronodular Adrenal Hyperplasia: A Case Report.

    Hiromu Matsunaga, Yuta Tezuka, Tomo Kinoshita, Hiroko Ogata, Yuto Yamazaki, Beata Shiratori, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Akihiro Ito, Hironobu Sasano, Hideo Harigae, Fumitoshi Satoh

    The Tohoku journal of experimental medicine　253　(2)　143-150　2021/02

    DOI： 10.1620/tjem.253.143 　

    More details Close

    Although adrenal resection is a major option to control hypercortisolemia in patients with bilateral macronodular adrenal hyperplasia, a predictive method for postoperative cortisol production has not been established. A 53-year-old man with ulcerative colitis was referred to our hospital for bilateral multiple adrenal nodules and hypertension. Physical and endocrinological examination revealed inappropriate cortisol production and suppressed secretion of adrenocorticotropic hormone with no typical signs of Cushing's syndrome. Imaging analysis revealed bilateral adrenal nodular enlargement, the nodules of which had the radiological features of adrenocortical adenomas without inter-nodular heterogeneity. In addition, computed tomography volumetry demonstrated that the left adrenal gland (70 mL) accounts for three quarters of the total adrenal volume (93 mL). The patient was diagnosed as subclinical Cushing's syndrome due to bilateral macronodular adrenal hyperplasia, and subsequently underwent a left laparoscopic adrenalectomy with the estimation of 75% decrease in the cortisol level based on the adrenal volume. The surgical treatment ultimately resulted in control of the cortisol level within the normal range, which was compatible to our preoperative prediction. However, regardless of the sufficient cortisol level, ulcerative colitis was exacerbated after the surgery, which needed a systemic therapy for remission. This case indicates successful surgical control of hypercortisolemia based on computed tomography volumetry in bilateral macronodular adrenal hyperplasia, as well as the perioperative exacerbation risk for inflammatory diseases in Cushing's syndrome. We report the potential utility of computed tomography volumetry as a quantitative method with retrospective evaluation of our historical cases.

  93. Treatment of Refractory Hypertension with Timely Angioplasty in Total Renal Artery Occlusion with Atrophic Kidney.

    Yuri Sasaki, Eikan Mishima, Koichi Kikuchi, Takafumi Toyohara, Takehiro Suzuki, Hideki Ota, Kazumasa Seiji, Mariko Miyazaki, Hideo Harigae, Sadayoshi Ito, Kei Takase, Takaaki Abe

    Internal medicine (Tokyo, Japan)　60　(2)　287-292　2021/01/15

    DOI： 10.2169/internalmedicine.5290-20 　

    More details Close

    Angioplasty for cases of chronic total occlusion of renal artery with/without atrophic kidney is generally not recommended. We herein report a 57-year-old man who presented with renin-mediated refractory hypertension caused by occlusion of a unilateral renal artery leading to kidney atrophy (length: 69 mm). Angioplasty favorably achieved blood pressure control with normalized renin secretion and enlargement of the atrophic kidney to 85 mm. Timely angioplasty can be beneficial in select patients, even with an atrophic kidney and total occlusion, especially in cases with deterioration of hypertension within six months and the presence of collateral perfusion to the affected kidney.

  94. Abnormal Findings on "T1WI or DWI or MRCP:" An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group. International-journal

    Hainan Ren, Naoko Mori, Minami Hirasawa, Shin Hamada, Shunji Mugikura, Atsushi Masamune, Kei Takase

    Journal of clinical imaging science　11　54-54　2021

    DOI： 10.25259/JCIS_158_2021 　

    More details Close

    Objectives: The objectives of the study was to evaluate the diagnostic performance of findings on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and magnetic resonance cholangiopancreatography (MRCP) separately and to identify an optimal Boolean interpretation model for discriminating patients with small pancreatic ductal adenocarcinoma (PDAC) from control groups in clinical practice. Material and Methods: We retrospectively enrolled 30 patients with surgery confirmed small PDAC (≤20 mm) and 302 patients without pancreatic abnormality between April 2008 and February 2020. The presence of masses was evaluated by T1WI, T2WI, and DWI. Abnormality of the main pancreatic duct (MPD) was evaluated by T2WI and MRCP. Multivariate logistic regression analysis was performed to select significant sequences for discriminating the small PDAC and control groups. Boolean operators "OR" or "AND" were used to construct sequence combinations. Diagnostic performances of these sequences and combinations were evaluated by X 2 tests. Results: The sensitivity of T2WI was lowest (20%) for detecting masses. For evaluating MPD abnormality, sensitivity was higher for MRCP than for T2WI (86.7% vs. 53.3%). Multivariate logistic regression analysis showed that T1WI and DWI for detecting the presence of masses and MRCP for evaluating MPD abnormality were significantly associated with differentiation between the two groups (P = 0.0002, P = 0.0484, and P < 0.0001, respectively). Seven combinations were constructed with T1WI, DWI, and MRCP. The combination of findings on "T1WI or DWI or MRCP" achieved the highest sensitivity of 96.7% and negative predictive value of 99.6%. Conclusion: The combination of findings on "T1WI or DWI or MRCP" might be an optimal interpretation model for discriminating small PDAC from control groups in clinical practice.

  95. Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. International-journal

    Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase

    European radiology　31　(1)　55-64　2021/01

    DOI： 10.1007/s00330-020-07047-6 　

    More details Close

    OBJECTIVES: The purpose of our study was to perform Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma, and to evaluate the relationship between histological grade and the ratios of the different clusters in each patient. METHODS: This retrospective study enrolled 122 patients (training: n = 63; and validation: n = 59) imaged between May 2015 and February 2020. In the training cohort, manual segmentation was performed on the ADC maps to obtain the ADC data of each patient, and these ADC data were summated to obtain the "All-patient" ADC data. Cluster analysis (three clusters) was performed on this All-patient ADC data, and the ADC ranges of each cluster were defined as follows: cluster 1, 490-699 × 10-6 mm2/s; cluster 2, 700-932 × 10-6 mm2/s; and cluster 3, over 933 × 10-6 mm2/s. In the training and validation cohorts, the ADC data of each patient was classified into three clusters according to these ADC ranges. The cluster ratios of each patient were calculated and compared with histological grade. RESULTS: In the training cohort, a significant positive correlation was found between the cluster 1 ratio and histological grade (ρ = 0.34, p = 0.0059). The cluster 1 ratios of high-grade lesions (grade 3) were significantly higher than those of low-grade lesions (grades 1 and 2) (p = 0.0084). A similar significant positive correlation was found between the cluster 1 ratio and histological grade in the validation cohort (ρ = 0.44, p = 0.0006). CONCLUSIONS: The cluster 1 ratio containing voxels with low ADC was significantly correlated with the histological grade of endometrioid carcinoma. KEY POINTS: • We performed Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma. • The cluster 1 ratio, which included low ADC values, was significantly positive correlated with histological grade in the training and validation cohorts. • The GMM-based cluster analysis of voxel-based ADC data was effective for grading endometrioid carcinoma.

  96. Aldosterone-induced cardiac damage in primary aldosteronism depends on its subtypes. International-journal

    Satoshi Higuchi, Hideki Ota, Yuta Tezuka, Kazumasa Seiji, Hidenobu Takagi, Jongmin Lee, Yi-Wei Lee, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, Kei Takase

    Endocrine connections　10　(1)　29-36　2021/01

    DOI： 10.1530/EC-20-0504 　

    More details Close

    Objectives: This study compared cardiac function, morphology, and tissue characteristics between two common subtypes of primary aldosteronism (PA) using a 3T MR scanner. Design: A retrospective, single-center, observational study. Methods: We retrospectively reviewed 143 consecutive patients with PA, who underwent both adrenal venous sampling and cardiac magnetic resonance. We acquired cine, late gadolinium enhancement, and pre- and postcontrast myocardial T1-mapping images. Results: PA was diagnosed as unilateral aldosterone-producing adenoma (APA) in 70 patients and bilateral hyperaldosteronism (BHA) in 73. The APA group showed significantly higher plasma aldosterone concentration (PAC) and aldosterone to renin rate (ARR) than the BHA group. After controlling for age, sex, antihypertensive drugs, systolic and diastolic blood pressure, and disease duration, the parameters independently associated with APA were: left ventricular end-diastolic volume index (EDVI: adjusted odds ratio (aOR) = 1.06 (95% CI: 1.030-1.096), P < 0.01), end-systolic volume index (ESVI: 1.06 (1.017-1.113), P < 0.01), stroke index (SI: 1.07 (1.020-1.121), P < 0.01), cardiac index (CI: 1.001 (1.000-1.001), P < 0.01), and native T1 (1.01 (1.000-1.019), P = 0.038). Weak positive correlations were found between PAC and EDVI (R = 0.28, P < 0.01), ESVI (0.26, P < 0.01), and SI (0.18, P = 0.03); and between ARR and EDVI (0.25, P < 0.01), ESVI (0.24, P < 0.01), and native T1 (0.17, P = 0.047). Conclusions: APA is associated with greater LV volumetric parameters and higher native T1 values, suggesting a higher risk of volume overload and myocardial damage.

  97. Embolization of a paraumbilical shunt by the transparaumbilical venous approach and one-sheath inverse method: A case report

    Hiroki Kamada, Hideki Ota, Kazumasa Seiji, Kei Takase

    Radiology Case Reports　15　(11)　2125-2128　2020/11

    DOI： 10.1016/j.radcr.2020.08.030 　

    eISSN： 1930-0433

  98. Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney. International-journal

    Tomoyuki Iwasaki, Eikan Mishima, Takehiro Suzuki, Koichi Kikuchi, Takafumi Toyohara, Kazumasa Seiji, Kei Takase, Mariko Miyazaki, Hideo Harigae, Sadayoshi Ito, Takaaki Abe

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(11)　1214-1221　2020/11

    DOI： 10.1038/s41440-020-0473-6 　

    More details Close

    Renal artery stenosis causes kidney ischemia, reducing the size of the affected kidney, which eventually results in atrophy. Although renal atrophy is considered irreversible, resolution of the ischemia occasionally restores kidney size when the cause is renal artery stenosis. Angioplasty is effective in patients with nonatherosclerotic renovascular diseases (non-ARVDs). Nevertheless, renal enlargement after angioplasty has not been fully examined. We conducted a retrospective study to examine this phenomenon in non-ARVD patients. Ten patients with a <100-mm pole-to-pole length of the poststenotic kidney were treated with angioplasty. Data were collected up to 12 months after angioplasty. The mean age was 28 years; the estimated glomerular filtration rate was 92 ± 7 mL/min/1.73 m2 (mean ± SEM); blood pressure was 150/99 mmHg; 80% were women; and fibromuscular dysplasia was present in 90% of the patients. All patients had hypertension. The lengths of the poststenotic and contralateral kidney before angioplasty were 91 ± 1 and 111 ± 3 mm, respectively. After angioplasty, the length of the poststenotic kidney gradually increased during the 3 months after treatment (+5.4 mm) and that of the contralateral kidney decreased over the same time course (-3.7 mm). Enlargement was also found in the moderate atrophy subgroup (length < 92 mm), and it was greater in the <30 years old group. In a noteworthy case, renal size in the poststenotic kidney recovered from 87 to 102 mm after angioplasty. Our findings demonstrated that reduced renal size can be reversed after optimal angioplasty in non-ARVD patients, especially young patients, suggesting reversibility of the ischemic kidney.

  99. 生体肝移植後の晩期胆道閉塞に対し超音波ガイド下に経皮的胆道空腸瘻形成を行った1例

    影山 咲子, 大田 英揮, 鎌田 裕基, 高瀬 圭, 宮城 重人

    超音波医学　47　(Suppl.)　S286-S286　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  100. Prognostic value of FDG-PET radiomics with machine learning in pancreatic cancer. International-journal

    Yoshitaka Toyama, Masatoshi Hotta, Fuyuhiko Motoi, Kentaro Takanami, Ryogo Minamimoto, Kei Takase

    Scientific reports　10　(1)　17024-17024　2020/10/12

    DOI： 10.1038/s41598-020-73237-3 　

    More details Close

    Patients with pancreatic cancer have a poor prognosis, therefore identifying particular tumor characteristics associated with prognosis is important. This study aims to investigate the utility of radiomics with machine learning using 18F-fluorodeoxyglucose (FDG)-PET in patients with pancreatic cancer. We enrolled 161 patients with pancreatic cancer underwent pretreatment FDG-PET/CT. The area of the primary tumor was semi-automatically contoured with a threshold of 40% of the maximum standardized uptake value, and 42 PET features were extracted. To identify relevant PET parameters for predicting 1-year survival, Gini index was measured using random forest (RF) classifier. Twenty-three patients were censored within 1 year of follow-up, and the remaining 138 patients were used for the analysis. Among the PET parameters, 10 features showed statistical significance for predicting overall survival. Multivariate analysis using Cox HR regression revealed gray-level zone length matrix (GLZLM) gray-level non-uniformity (GLNU) as the only PET parameter showing statistical significance. In RF model, GLZLM GLNU was the most relevant factor for predicting 1-year survival, followed by total lesion glycolysis (TLG). The combination of GLZLM GLNU and TLG stratified patients into three groups according to risk of poor prognosis. Radiomics with machine learning using FDG-PET in patients with pancreatic cancer provided useful prognostic information.

  101. Effective apparent diffusion coefficient parameters for differentiation between mass-forming autoimmune pancreatitis and pancreatic ductal adenocarcinoma

    Hainan Ren, Naoko Mori, Shin Hamada, Chiaki Takasawa, Shunji Mugikura, Atsushi Masamune, Kei Takase

    Abdominal Radiology　2020/10/10

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00261-020-02795-x 　

    ISSN： 2366-004X

    eISSN： 2366-0058

  102. Dose-dependent Radiation-induced Myocardial Damage in Esophageal Cancer Treated with Chemoradiotherapy: A Prospective Cardiac Magnetic Resonance Imaging Study Peer-reviewed

    Rei Umezawa, Noriyuki Kadoya, Hideki Ota, Yujiro Nakajima, Masahide Saito, Hidenobu Takagi, Kentaro Takanami, Noriyoshi Takahashi, Yojiro Ishikawa, Takaya Yamamoto, Haruo Matsushita, Ken Takeda, Kei Takase, Keiichi Jingu

    Advances in Radiation Oncology　5　(6)　1170-1178　2020/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.adro.2020.07.012 　

    ISSN： 2452-1094

  103. Detection of the intimal tear in aortic dissection and ulcer-like projection in intramural hematoma: usefulness of full-phase retrospective ECG-gated CT angiography

    Satoru Yanagaki, Takuya Ueda, Atsuro Masuda, Hideki Ota, Yuta Onaka, Masatoshi Kojima, Takashi Hattori, Wahei Mihara, Kei Takase

    Japanese Journal of Radiology　2020/07/24

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11604-020-01008-1 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  104. Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis. International-journal Peer-reviewed

    Michiko Kano, Cecilia Grinsvall, Qian Ran, Patrick Dupont, Joe Morishita, Tomohiko Muratsubaki, Shunji Mugikura, Huynh Giao Ly, Hans Törnblom, Maria Ljungberg, Kei Takase, Magnus Simrén, Lukas Van Oudenhove, Shin Fukudo

    Scientific reports　10　(1)　11015-11015　2020/07/03

    DOI： 10.1038/s41598-020-67048-9 　

    More details Close

    Irritable bowel syndrome (IBS) is a functional disorder of brain-gut interactions. Differential brain responses to rectal distention between IBS and healthy controls (HCs) have been demonstrated, particularly in the pain matrix and the default mode network. This study aims to compare resting-state functional properties of these networks between IBS patients and HCs using graph analysis in two independent cohorts. We used a weighted graph analysis of the adjacency matrix based on partial correlations between time series in the different regions in each subject to determine subject specific graph measures. These graph measures were normalized by values obtained in equivalent random networks. We did not find any significant differences between IBS patients and controls in global normalized graph measures, hubs, or modularity structure of the pain matrix and the DMN in any of our two independent cohorts. Furthermore, we did not find consistent associations between these global network measures and IBS symptom severity or GI-specific anxiety but we found a significant difference in the relationship between measures of psychological distress (anxiety and/or depressive symptoms) and normalized characteristic path length. The responses of these networks to visceral stimulation rather than their organisation at rest may be primarily disturbed in IBS.

  105. 乳癌患者における化学療法による心毒性が原因の局所左室変形に関する経時的変化(Longitudinal Change of Regional Left Ventricular Deformation by Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

    藤原 淳子, 後岡 広太郎, 杉村 宏一郎, 照井 洋輔, 佐藤 遥, 多田 寛, 大田 英揮, 船水 康陽, 三木 俊, 西條 芳文, 高瀬 圭, 石田 孝宜, 下川 宏明

    日本循環器学会学術集会抄録集　84回　OJ12-6　2020/07

    Publisher: (一社)日本循環器学会

  106. 乳癌患者における化学療法による心毒性が原因の局所左室変形に関する経時的変化(Longitudinal Change of Regional Left Ventricular Deformation by Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

    藤原 淳子, 後岡 広太郎, 杉村 宏一郎, 照井 洋輔, 佐藤 遥, 多田 寛, 大田 英揮, 船水 康陽, 三木 俊, 西條 芳文, 高瀬 圭, 石田 孝宜, 下川 宏明

    日本循環器学会学術集会抄録集　84回　OJ12-6　2020/07

    Publisher: (一社)日本循環器学会

  107. 18F-FDG PET/CT Imaging of Vasculitis Complicated With Relapsing Polychondritis. International-journal

    Hiroki Kamada, Kentaro Takanami, Yoshitaka Toyama, Mioko Saito, Kei Takase

    Clinical nuclear medicine　45　(7)　e327-e328　2020/07

    DOI： 10.1097/RLU.0000000000003060 　

    More details Close

    We present a case of a 38-year-old woman who complained with cough, fever, and back pain with a weight loss. F-FDG PET/CT to search fever origin revealed uptake in the tracheobronchial and the left auricular cartilage and wall of the thoracic aorta. She underwent biopsy of the left auricle and was diagnosed with relapsing polychondritis (RP) complicating vasculitis. After steroid therapy, FDG PET/CT demonstrated regression of inflammation, showing decreases in the uptakes. Vasculitis should be considered in case of RP with systemic manifestations. Our case demonstrated the utility of FDG PET/CT in evaluation of RP lesions including aortitis.

  108. Thrombosis of a basilar perforator aneurysm associated with pontine infarction in a patient with systemic lupus erythematosus

    Takaki Murata, Shuko Nomura, Eiko Yamamori, Shoki Takahashi, Kei Takase

    Radiology Case Reports　15　(6)　757-760　2020/06/01

    Publisher: Elsevier Inc

    DOI： 10.1016/j.radcr.2020.03.009 　

    ISSN： 1930-0433

  109. Clinical implication of myocardial FDG uptake pattern in oncologic PET: retrospective comparison study with stress myocardial perfusion imaging as the reference standard

    Kentaro Takanami, Mioko Saito, Yasuharu Matsumoto, Koichiro Sugimura, Kei Takase

    Annals of Nuclear Medicine　34　(4)　233-243　2020/04

    DOI： 10.1007/s12149-020-01437-y 　

    ISSN： 0914-7187

    eISSN： 1864-6433

  110. 【腎・泌尿器の画像診断update】原発性アルドステロン症の診断・治療

    清治 和将, 大田 英揮, 手塚 雄太, 尾股 慧, 小野 美澄, 森本 玲, 佐藤 文俊, 高瀬 圭

    画像診断　40　(6)　589-605　2020/04

    Publisher: (株)学研メディカル秀潤社

    ISSN： 0285-0524

    eISSN： 2432-1281

  111. Turbo Spin-echo Diffusion-weighted Imaging Compared with Single-shot Echo-planar Diffusion-weighted Imaging: Image Quality and Diagnostic Performance When Differentiating between Ductal Carcinoma in situ and Invasive Ductal Carcinoma. Peer-reviewed

    Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yui Maekawa, Tatsuo Nagasaka, Kei Takase

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　20　(1)　60-68　2020/03/06

    DOI： 10.2463/mrms.mp.2019-0195 　

    More details Close

    PURPOSE: To compare the image quality between turbo spin-echo (TSE)-diffusion weighted imaging (DWI) and single-shot echo-planar imaging (EPI)-DWI, and to verify the diagnostic performance of the apparent diffusion coefficient (ADC) parameters of the two techniques by using histogram analysis in terms of differentiation between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) lesions. METHODS: Ninety-four women with 94 lesions diagnosed as breast cancer by surgery underwent IRB-approved preoperative magnetic resonance imaging, including TSE and EPI-DWI with b-values of 50 and 850 s/mm2. Twenty lesions were identified as DCIS and 74 as IDC. Image quality [signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and geometric distortion] was evaluated quantitatively and compared between the TSE and EPI-DWI. A histogram analysis of the entire tumor voxel-based ADC data was performed, and the 10th, 25th, 50th, 75th, and 90th percentile values of each technique were compared between DCIS and IDC lesions. RESULTS: The SNR and CNR of TSE-DWI were significantly higher than those of EPI-DWI (P < 0.0001 and < 0.0001). The geometric distortion of TSE-DWI was significantly lower than that of EPI-DWI (P < 0.0001). In TSE-DWI, the 10th, 25th, 50th, and 75th percentile values were significantly different between the DCIS and IDC lesions (P = 0.0010, 0.0004, 0.0008, and 0.0044, respectively). In EPI-DWI, the 50th and 75th percentile values were significantly different between the two groups (P = 0.0009 and 0.0093). There was no significant difference in the area under the curve of the receiver operating characteristic analysis of the 10th, 25th, 50th, and 75th percentile values of TSE-DWI, and the 50th and 75th percentile values of EPI-DWI (P = 0.29). CONCLUSION: The image quality of TSE-DWI was better than that of EPI-DWI. DCIS lesions were distinguished from IDC lesions with a wider range of percentile values in TSE-DWI than in EPI-DWI, although diagnostic performance was not significantly different between the techniques.

  112. Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm Peer-reviewed

    Shunji Mugikura, Naoko Mori, Hirokazu Kikuchi, Etsuro Mori, Shoki Takahashi, Kei Takase

    Annals of Nuclear Medicine　34　(3)　220-227　2020/03

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12149-020-01436-z 　

    ISSN： 0914-7187

    eISSN： 1864-6433

    More details Close

    <title>Abstract</title><sec> <title>Objective</title> Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia. </sec><sec> <title>Methods</title> Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on 123I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. The Severity (average <italic>Z</italic> score of the voxels with a <italic>Z</italic> score that exceeds a threshold value of 2) was calculated. The cerebral lobes with rCBF exhibiting Severity &gt; 2 in all patients were identified. In these lobes, we then examined whether there was a gyrus exhibiting Severity that was negatively related to memory quotients (MQs). </sec><sec> <title>Results</title> In the right subcallosal gyrus, there was a significant negative correlation between Severity and visual MQ (<italic>ρ</italic>= −  0.884, <italic>p</italic> = 0.0007) or general MQ (<italic>ρ</italic> =− 0.853, <italic>p</italic> = 0.0017). In the right anterior cingulate gyrus, there was a significant negative correlation between Severity and verbal MQ (<italic>ρ</italic> = − 0.769, <italic>p</italic> = 0.0092). In the right rectal gyrus, there was a significant negative correlation between Severity and general MQ (<italic>ρ</italic> =  −  0.811, <italic>p</italic> = 0.0044). No significant correlations were found between Severity in other brain regions and verbal, visual, or general MQ. </sec><sec> <title>Conclusions</title> The decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia. </sec>

  113. Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm.

    Shunji Mugikura, Naoko Mori, Hirokazu Kikuchi, Etsuro Mori, Shoki Takahashi, Kei Takase

    Annals of nuclear medicine　34　(3)　220-227　2020/03

    DOI： 10.1007/s12149-020-01436-z 　

    More details Close

    OBJECTIVE: Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia. METHODS: Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on 123I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. The Severity (average Z score of the voxels with a Z score that exceeds a threshold value of 2) was calculated. The cerebral lobes with rCBF exhibiting Severity > 2 in all patients were identified. In these lobes, we then examined whether there was a gyrus exhibiting Severity that was negatively related to memory quotients (MQs). RESULTS: In the right subcallosal gyrus, there was a significant negative correlation between Severity and visual MQ (ρ= -  0.884, p = 0.0007) or general MQ (ρ =- 0.853, p = 0.0017). In the right anterior cingulate gyrus, there was a significant negative correlation between Severity and verbal MQ (ρ = - 0.769, p = 0.0092). In the right rectal gyrus, there was a significant negative correlation between Severity and general MQ (ρ =  -  0.811, p = 0.0044). No significant correlations were found between Severity in other brain regions and verbal, visual, or general MQ. CONCLUSIONS: The decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia.

  114. 4D-flow MRI assessment of blood flow before and after endovascular intervention in a patient with pulmonary hypertension due to isolated pulmonary artery involvement in large vessel vasculitis. International-journal

    Hiroki Kamada, Hideki Ota, Tatsuo Aoki, Koichiro Sugimura, Nobuhiro Yaoita, Hiroaki Shimokawa, Kei Takase

    Radiology case reports　15　(3)　190-194　2020/03

    DOI： 10.1016/j.radcr.2019.11.019 　

    More details Close

    A 43-year-old woman presented with dyspnea during exertion and lower leg edema. Contrast-enhanced computed tomography images demonstrated extensive proximal narrowing in the right main pulmonary artery with thickening and enhancement. Right heart catheterization revealed the presence of precapillary pulmonary hypertension with a mean pulmonary arterial pressure of 45 mm Hg. The patient was diagnosed with large-vessel vasculitis with isolated pulmonary artery involvement. Takayasu's arteritis was suspected, but histological examination was not performed. Several sessions of pulmonary arterial intervention were stratified for the right main pulmonary artery. After treatment, mean pulmonary arterial pressure had decreased to 22 mm Hg with improvement in symptoms. Thoracic 4D-flow magnetic resonance imaging was performed before and after intervention to evaluate the volume flow rates of pulmonary arteries. The rates increased at the inlet of the right pulmonary artery (before: 23 mL/s vs after: 47.5 mL/s) and the main pulmonary artery (before: 71.2 mL/s vs after: 82.5 mL/s), and decreased at the inlet of the left pulmonary artery (before: 46.2 mL/s vs after: 31.7 mL/s). The split ratio of volume flow rate between the right and left pulmonary arteries improved after treatment (before. right:left = 33.1:66.9; after, right:left = 60.0:40.0), approaching normal values. This report quantitatively describes perioperative hemodynamic changes in a patient with pulmonary hypertension using 4D-flow magnetic resonance imaging. Stent placement for stenosis in the right pulmonary artery resulted in an increase in overall pulmonary blood flow and also improved blood flow balance between the right and the left pulmonary arteries.

  115. 縦隔に発生したFollicular dendritic cell sarcomaの1例

    竹下 翔, 佐藤 嘉尚, 冨永 循哉, 高瀬 圭, 井上 千裕, 齊藤 涼子

    Japanese Journal of Radiology　38　(Suppl.)　6-6　2020/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  116. 中期経過観察された食道癌化学放射線療法後における心事故と心臓MRI所見の関連性

    梅澤 玲, 角谷 倫之, 松下 晴雄, 山本 貴也, 石川 陽二郎, 片桐 佑, 武田 一也, 福井 勝哉, 田坂 俊, 鈴木 友, 川端 広聖, 岸田 桂太, 寺村 聡司, 尾股 聡, 伊藤 謙吾, 高山 佳樹, 千葉 貴仁, 神宮 啓一, 大田 英揮, 高瀬 圭

    Japanese Journal of Radiology　38　(Suppl.)　9-9　2020/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  117. Three cases of pulmonary tumor thrombotic microangiopathy (PTTM): Challenge in antemortem diagnosis using lung perfusion blood volume images by dual-energy computed tomography. International-journal

    Hiroki Kamada, Hideki Ota, Yosuke Terui, Koichiro Sugimura, Shigefumi Fukui, Hiroaki Shimokawa, Kei Takase

    European journal of radiology open　7　100212-100212　2020

    DOI： 10.1016/j.ejro.2020.01.001 　

    More details Close

    Pulmonary tumor thrombotic microangiopathy (PTTM) is a specific type of tumor embolism in the small and medium pulmonary arteries, leading to rapid progressive pulmonary hypertension. Antemortem diagnosis of PTTM is extremely difficult. We encountered three patients who were histopathologically or clinically diagnosed with PTTM. In all cases, lung perfused blood volume (PBV) images on dual-energy computed tomography (CT) demonstrated multiple subpleural wedge-shaped defects with no evidence of pulmonary embolism on CT pulmonary angiography. The lung PBV images demonstrated small pulmonary arterial obstruction reflecting the pathology of PTTM. Therefore, lung PBV imaging would be useful for antemortem diagnosis of PTTM.

  118. 最新半導体PET/CTにおける上腹部病変への呼吸同期の有用性

    外山 由貴, 高浪 健太郎, 太田 瑛梨, 加賀谷 由里子, 前川 由依, 齊藤 美穂子, 高瀬 圭

    核医学　57　(1)　5-5　2020

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  119. 後腹膜腫瘍切除後椎骨動脈瘤破裂による気道閉塞から心肺停止をきたした神経線維腫症I型の1救命例

    三浦 孝之, 水間 正道, 元井 冬彦, 内藤 剛, 亀井 尚, 高瀬 圭, 海野 倫明

    Japanese Journal of Acute Care Surgery　9　(2)　254-257　2020/01

    Publisher: 日本Acute Care Surgery学会

    eISSN： 2436-102X

  120. Perioperative Hemodynamic Changes in the Thoracic Aorta in Patients With Aortic Valve Stenosis: A Prospective Serial 4D-Flow MRI Study. International-journal Peer-reviewed

    Hiroki Kamada, Hideki Ota, Masanori Nakamura, Yohsuke Imai, Shunichi Ishida, Wenyu Sun, Ko Sakatsume, Ichiro Yoshioka, Yoshikatsu Saiki, Kei Takase

    Seminars in thoracic and cardiovascular surgery　32　(1)　25-34　2020

    DOI： 10.1053/j.semtcvs.2019.07.006 　

    ISSN： 1043-0679

    More details Close

    This study investigated hemodynamic changes in the thoracic aorta and aortic arch branches before and after aortic valve replacement (AVR) by 4D-flow MRI in patients with aortic valve stenosis (AS). Thoracic 4D-flow MRI was performed in 10 AS patients before and after AVR (mean 27 ± 1.9 days). Fifteen aortic planes and 3 aortic arch branches planes were set to evaluate the mean volume flow rate in each plane during a cardiac cycle and the angle between the main flow direction in a specified plane and the axial direction of the aorta. We also focused on the distribution and magnitude of helicity density to evaluate the flow complexity. A significant increase in the volume flow rate after AVR was found in the ascending aorta (before 59.2 ± 8.7 mL/s vs after 77.3 ± 6.2 mL/s, P < 0.05) and the aortic arch branches (before 26.5 ± 2.8 mL/s vs after 35.8 ± 3.3 mL/s, P < 0.001). The flow angle significantly decreased in the ascending aorta (before 39.2 ± 2.7 degree vs after 25.2 ± 1.7°, P < 0.0001) and the arch aorta (before 19.3 ± 2.0 degree vs after 13.4 ± 0.9°, P < 0.001). The volume flow rate in the ascending aorta and the arch branches increased within 1 month after AVR, showing an increased blood supply to the upper body, including to the brain. The postoperative change was accompanied with an increased blood flow in the ascending aorta and a decreased flow complexity proximal to the arch branches.

  121. Insula Activity to Visceral Stimulation and Endocrine Stress Responses as Associated With Alexithymia in Patients With Irritable Bowel Syndrome. International-journal Peer-reviewed

    Michiko Kano, Tomohiko Muratsubaki, Mao Yagihashi, Joe Morishita, Shunji Mugikura, Patrick Dupont, Kei Takase, Motoyori Kanazawa, Lukas Van Oudenhove, Shin Fukudo

    Psychosomatic medicine　82　(1)　29-38　2020/01

    DOI： 10.1097/PSY.0000000000000729 　

    ISSN： 0033-3174

    More details Close

    OBJECTIVE: Few studies have investigated associations between alexithymia and physiological mechanisms in psychosomatic diseases. We examined associations between alexithymia and 1) perception and brain processing of visceral stimulation and 2) the endocrine responses to corticotrophin-releasing hormone (CRH) in healthy individuals and patients with irritable bowel syndrome (IBS). METHODS: The study included 29 patients with IBS and 35 age- and sex-matched healthy controls (HCs). Alexithymia was measured using the 20-item Toronto Alexithymia Scale (TAS-20). Brain responses to rectal distention and its anticipation were measured by functional magnetic resonance imaging and analyzed at a voxel-level threshold of puncorrected < .001 combined with a cluster-level threshold of pFWE-corrected < .05. On a different day, plasma adrenocorticotropic hormone and cortisol responses after intravenous CRH administration were measured. RESULTS: TAS-20 scores did not differ significantly between patients with IBS and HCs (p = .18). TAS-20 scores correlated positively with the individual rectal discomfort thresholds (βrobust = 0.49, p = .03) and negatively with the rating of fear before rectal distention (βrobust = -1.63, p = .04) in patients with IBS but not in HCs. Brain responses to rectal distention in the right insula and other brain regions were positively associated with TAS-20 scores to a greater extent in patients with IBS than in HCs. Individuals with higher TAS-20 scores (both patients with IBS and HCs) demonstrated stronger adrenocorticotropic hormone responses to CRH administration (F(4,224) = 3.54, p = .008). CONCLUSION: Higher alexithymia scores are associated with stronger physiological responses, but lower anticipatory fear ratings and higher discomfort thresholds, particularly in patients with IBS.

  122. Association of the incidence of venous air embolism on coronary computed tomography angiography with the intravenous access route preparation process. Peer-reviewed

    Kayano S, Ota H, Yamaguchi T, Ono K, Takase K

    Medicine　98　(45)　e17940　2019/11

    DOI： 10.1097/MD.0000000000017940 　

    ISSN： 0025-7974

    eISSN： 1536-5964

  123. CardioOncologyの現状と未来 当院データと本邦における多施設共同研究への発展

    杉村 宏一郎, 大田 英揮, 多田 寛, 照井 洋輔, 佐藤 遥, 後岡 広太郎, 石田 孝宣, 高瀬 圭, 下川 宏明

    日本心臓病学会学術集会抄録　67回　SS-3　2019/09

    Publisher: (一社)日本心臓病学会

  124. 肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 宮崎 勇希, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 大田 英揮, 高瀬 圭, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　200-200　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  125. 頭部CT Angiographyを想定するヒストグラム解析を用いた撮影タイミングの決定法に関する基礎的検証

    茅野 伸吾, 藤盛 陽介, 高野 博和, 高根 侑美, 大村 知己, 千葉 雄高, 大田 英揮, 高瀬 圭

    日本放射線技術学会雑誌　75　(9)　1075-1075　2019/09

    Publisher: (公社)日本放射線技術学会

    ISSN： 0369-4305

    eISSN： 1881-4883

  126. ちょっと気になる胆・膵画像 ティーチングファイルから(第42回) 肝内外に多発病変を認めた胆管内乳頭状腫瘍の1例

    影山 咲子, 大田 英揮, 前川 由依, 高浪 健太郎, 藤島 史喜, 高瀬 圭

    胆と膵　40　(8)　661-664　2019/08

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  127. 新型FDG PETで多数の神経節に集積を認めたNeurolymphomatosisの一例

    加藤 恵里奈, 外山 由貴, 太田 瑛梨, 高橋 梢, 前川 由依, 加賀谷 由里子, 村田 隆紀, 斎藤 美穂子, 高浪 健太郎, 高瀬 圭

    核医学　56　(1)　101-101　2019/07

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  128. Ultrafast Dynamic Contrast-Enhanced Breast MRI: Kinetic Curve Assessment Using Empirical Mathematical Model Validated with Histological Microvessel Density Peer-reviewed

    Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Chiaki Takasawa, Satoko Sato, Minoru Miyashita, Yu Mori, Federico D. Pineda, Gregory S. Karczmar, Hajime Tamura, Shoki Takahashi, Kei Takase

    Academic Radiology　26　(7)　e141-e149　2019/07

    DOI： 10.1016/j.acra.2018.08.016 　

    ISSN： 1076-6332

    eISSN： 1878-4046

  129. Effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling: a preliminary study using computational fluid dynamics. International-journal Peer-reviewed

    Tomo Kinoshita, Kazumasa Seiji, Narendra Kurnia Putra, Tomohito Watanabe, Sho Matsumoto, Makoto Ohta, Kei Takase

    Medical & biological engineering & computing　57　(7)　1425-1436　2019/07

    DOI： 10.1007/s11517-019-01968-1 　

    ISSN： 0140-0118

    More details Close

    This study aimed to evaluate the effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling. A three-dimensional fluid-structure interaction simulation was performed using commercial finite element software. A computational model of a vein with a catheter inserted into it was constructed. The outer and inner diameters of the vein were 0.9 mm and 0.6 mm, respectively, whereas those of the catheter were 0.6 mm and 0.5 mm, respectively. The velocity of the blood flow at the outlet was 85 mm/s. The pressure at the inlet was 0 Pa. The mesh consisted of approximately 660,000 elements. The effect of the number (0-4) and shape (no notch, 1/4 circular, 1/3 circular, semicircular, 2/3 circlecircular, and 3/4 circular) of the notches at the distal end of the microcatheter on the vein deformation when a suction pressure was applied was evaluated. The venous wall displacement was the smallest with the one-notch catheter, followed by the four-notch catheter, and was the smallest with the catheter having 1/4-circular notches, followed by the one with 1/3-circular notches. In conclusion, microcatheters having one notch and 1/4-circular notches reduce vein deformation and lead to successful segmental adrenal venous sampling. Graphical abstract Comparing catheters having different notch shapes.

  130. Changes in quality of life after laparoscopic adrenalectomy for patients with primary aldosteronism: Prospective 2-year longitudinal cohort study in a Japanese tertiary center. Peer-reviewed

    Ishidoya S, Kawasaki Y, Namiki S, Morimoto R, Takase K, Ito A

    International journal of urology : official journal of the Japanese Urological Association　26　(7)　752-753　2019/07

    DOI： 10.1111/iju.14016 　

    ISSN： 0919-8172

  131. Usefulness of Diffusion-Weighted Magnetic Resonance Imaging Using Apparent Diffusion Coefficient Values for Diagnosis of Infantile Hemangioma. Peer-reviewed

    Saito M, Kitami M, Takase K

    Journal of computer assisted tomography　43　(4)　563-567　2019/07

    DOI： 10.1097/RCT.0000000000000884 　

    ISSN： 0363-8715

    eISSN： 1532-3145

  132. Validating an Empirical Mathematical Model for Dynamic Contrast-enhanced MR Imaging of Hand and Wrist Synovitis in Rheumatoid Arthritis: Correlation of Model Parameters with Clinical Disease Activity. Peer-reviewed

    Ochi J, Mori N, Mori Y, Mugikura S, Hitachi S, Itoi E, Takase K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　19　(3)　176-183　2019/07

    DOI： 10.2463/mrms.mp.2019-0026 　

    ISSN： 1347-3182

    eISSN： 1880-2206

  133. 急速に進行したMyxoid型副腎皮質癌の一例

    手塚 雄太, 森本 玲, 白鳥 ベアタ, 尾股 慧, 小野 美澄, 工藤 正孝, 五十嵐 康宏, 大田 英揮, 高瀬 圭, 宮城 重人, 山崎 有人, 笹野 公伸, 伊藤 貞嘉, 佐藤 文俊

    日本内分泌学会雑誌　95　(Suppl.Update)　77-80　2019/06

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  134. A case of iatrogenic air bubbles in the left ventricle by coronary computed tomographic angiography. International-journal Peer-reviewed

    Kayano S, Takahashi A, Ota H, Takase K

    Radiology case reports　14　(6)　687-691　2019/06

    DOI： 10.1016/j.radcr.2019.03.017 　

    More details Close

    We report a case of asymptomatic iatrogenic air bubbles in the left ventricle observed by coronary computed tomographic angiography. Air bubbles are rarely found in the left ventricle and could prove fatal should they migrate to the brain or coronary arteries. We believe that the cause is micro air bubbles in the tubing system between the intravenous catheter and power injector.

  135. 18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status. International-journal Peer-reviewed

    Yuta Tezuka, Yuto Yamazaki, Masaaki Kitada, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Koji Mitsuzuka, Akihiro Ito, Jun Nishikawa, Noriko Asai, Yasuhiro Nakamura, Celso E Gomez-Sanchez, Sadayoshi Ito, Mari Dezawa, Hironobu Sasano, Fumitoshi Satoh

    Hypertension (Dallas, Tex. : 1979)　73　(6)　1283-1290　2019/06

    DOI： 10.1161/HYPERTENSIONAHA.118.12064 　

    ISSN： 0194-911X

    More details Close

    Peripheral 18-oxocortisol (18oxoF) level could contribute to the detection of aldosterone-producing adenoma (APA) in patients with primary aldosteronism. However, peripheral 18oxoF varies among such patients, which is a big drawback concerning its clinical application. We studied 48 cases of APA, 35 harboring KCNJ5 mutation, to clarify the significance of clinical and pathological parameters about peripheral 18oxoF. Peripheral 18oxoF concentration ranged widely from 0.50 to 183.13 ng/dL and correlated positively with intratumoral areas stained positively for steroidogenic enzymes ( P<0.0001). The peripheral 18oxoF level also correlated significantly with that of circulating aldosterone ( P<0.0001) but not with that of cortisol, a precursor of 18oxoF. However, a significant correlation was detected between peripheral 18oxoF and intratumoral glucocorticoids ( P<0.05). In addition, peripheral 18oxoF correlated positively with the number of hybrid cells double positive for 11β-hydroxylase and aldosterone synthase ( P<0.0001). Comparing between the cases with and those without KCNJ5 mutation, the KCNJ5-mutated group demonstrated a significantly higher concentration of peripheral 18oxoF (28.4±5.6 versus 3.0±0.9 ng/dL, P<0.0001) and a larger intratumoral environment including the hybrid cells ( P<0.001), possibly representing a deviation from normal aldosterone biosynthesis. After multivariate analysis, KCNJ5 mutation status turned out to be the most associated factor involved in 18oxoF synthesis in APA ( P<0.0001). Results of our present study first revealed that enhanced 18oxoF synthesis in APA could come from a functional deviation of aldosterone biosynthesis from the normal zona glomerulosa and the utility of peripheral 18oxoF measurement could be influenced by the prevalence of KCNJ5 mutation in an APA.

  136. Parasympathetic activity correlates with subjective and brain responses to rectal distension in healthy subjects but not in non-constipated patients with irritable bowel syndrome. International-journal Peer-reviewed

    Michiko Kano, Makoto Yoshizawa, Keiji Kono, Tomohiko Muratsubaki, Joe Morishita, Lukas Van Oudenhove, Mao Yagihashi, Shunji Mugikura, Patrick Dupont, Kei Takase, Motoyori Kanazawa, Shin Fukudo

    Scientific reports　9　(1)　7358-7358　2019/05/14

    DOI： 10.1038/s41598-019-43455-5 　

    More details Close

    The nociceptive and autonomic nervous systems (ANS) are significantly intertwined. Decoupling of these systems may occur in pathological pain conditions, including irritable bowel syndrome (IBS). We investigated ANS activity and its association with visceral perception and brain activity during rectal distention in 27 patients with non-constipated IBS and 33 controls by assessing heart rate variability (HRV) using electrocardiography at rest, before, and during colorectal distention. Brain responses to colorectal distention were measured using functional magnetic resonance imaging and correlated with individual ANS function parameters. The IBS group displayed blunted sympathovagal balance [low/high-frequency ratio (LF:HF) of HRV] in response to colorectal distention compared with controls (P = 0.003). In controls, basal parasympathetic tone (HF component of HRV) was significantly negatively correlated with toleration threshold to the rectal distention, but not in patients with IBS (group comparison P = 0.04). Further, a positive correlation between baseline HF values and neural responses to rectal distension was found in the right caudate, bilateral dorsolateral anterior cingulate cortex, and pregenual anterior cingulate cortex in the control group but not in the IBS group. The results indicate abnormal interactions between ANS activity and the brain mechanisms underlying visceral perception in patients with IBS.

  137. Atrophy of the ipsilateral mammillary body in unilateral hippocampal sclerosis shown by thin-slice-reconstructed volumetric analysis. International-journal Peer-reviewed

    Yohei Morishita, Shunji Mugikura, Naoko Mori, Hajime Tamura, Shiho Sato, Toshiaki Akashi, Kazutaka Jin, Nobukazu Nakasato, Kei Takase

    Neuroradiology　61　(5)　515-523　2019/05

    DOI： 10.1007/s00234-019-02158-4 　

    ISSN： 0028-3940

    More details Close

    PURPOSE: Conventional volumetric analysis could not detect ipsilateral atrophy of the mammillary body in patients with unilateral hippocampal sclerosis. By using thin-slice-reconstructed volumetric analysis, we investigated whether the mammillary body volume is smaller on the hippocampal sclerosis side than in healthy subjects or the non-hippocampal sclerosis side. METHODS: This retrospective study included 45 patients with unilateral hippocampal sclerosis and 30 healthy subjects. Three-dimensional T1WI of 1 mm thicknesses were oversampled to a thickness of 0.2 mm (thin-slice-reconstructed images), and the mammillary bodies were segmented manually to determine mammillary body volume on each side. Mammillary body volumes on the hippocampal sclerosis side were compared with those in healthy subjects or the non-hippocampal sclerosis side. RESULTS: In patients with right hippocampal sclerosis, right mammillary body volume was both significantly smaller than that in healthy subjects (30.3 ± 10.3 vs. 43.3 ± 8.07 mm3, P < 0.001) and significantly smaller than the left mammillary body volume in each patient (30.3 ± 10.3 vs. 41.4 ± 10.1 mm3, P < 0.001). Similarly, in patients with left hippocampal sclerosis, left mammillary body volume was both significantly smaller than that in healthy subjects (37.7 ± 11.2 vs. 47.0 ± 8.65 mm3, P < 0.001) and significantly smaller than right mammillary body volume in each patient (37.7 ± 11.2 vs. 42.5 ± 7.78 mm3, P = 0.044). CONCLUSIONS: In this study, thin-slice-reconstructed volumetric analysis showed that, in patients with unilateral hippocampal sclerosis, mammillary body volume on the hippocampal sclerosis side is smaller than that in healthy subjects and the non-hippocampal sclerosis side.

  138. 3T MRI evaluation of regional catecholamine-producing tumor-induced myocardial injury. International-journal Peer-reviewed

    Satoshi Higuchi, Hideki Ota, Takuya Ueda, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, Kei Takase

    Endocrine connections　8　(5)　454-461　2019/05/01

    DOI： 10.1530/EC-18-0553 　

    More details Close

    Objective: Regional differences in cardiac magnetic resonance, which can reveal catecholamine-induced myocardial injury in patients with pheochromocytoma, have not yet been assessed using 3T magnetic resonance imaging. We evaluated these differences using myocardial T1-mapping and strain analysis. Design and Methods: We retrospectively reviewed 16 patients newly diagnosed with catecholamine-producing tumors (CPT group) and 16 patients with essential hypertension (EH group), who underwent cardiac magnetic resonance imaging between May 2016 and March 2018. We acquired 3T magnetic resonance cine and native T1-mapping images and performed feature-tracking-based strain analysis in the former. Results: Global cardiac function, morphology, global strain and peak strain rate were similar, but end-diastolic wall thickness differed between groups (CPT vs EH: 10.5 ± 1.7 vs 12.6 ± 2.8 mm; P < 0.05). Basal, but not apical, circumferential strain was significantly higher in the CPT than the EH group (19.4 ± 3.2 vs 16.8 ± 3.6 %; P < 0.05). Native T1 values were significantly higher in CPT than in EH patients, in both the basal septum (1307 ± 48 vs 1241 ± 45 ms; P < 0.01) and the apical septum (1377 ± 59 vs 1265 ± 58 ms; P < 0.01) mid-walls. In the CPT, but not in the EH group, native T1 values in the apical wall were significantly higher than those in the basal wall (P < 0.01). Conclusion: 3T magnetic resonance-based T1-mapping can sensitively detect subclinical catecholamine-induced myocardial injury; the influence of catecholamines may be greater in the apical than in the basal wall.

  139. Diagnostic value of electric properties tomography (EPT) for differentiating benign from malignant breast lesions: comparison with standard dynamic contrast-enhanced MRI. Peer-reviewed

    Mori N, Tsuchiya K, Sheth D, Mugikura S, Takase K, Katscher U, Abe H

    European radiology　29　(4)　1778-1786　2019/04

    DOI： 10.1007/s00330-018-5708-4 　

    ISSN： 0938-7994

  140. Perfusion contrast-enhanced ultrasound to predict early lymph-node metastasis in breast cancer Peer-reviewed

    Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yumiko Kudo, Mikiko Suzuki, Li Li, Yu Mori, Shoki Takahashi, Kei Takase

    Japanese Journal of Radiology　37　(2)　145-153　2019/02/20

    DOI： 10.1007/s11604-018-0792-6 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  141. 慢性血栓塞栓性肺高血圧症の治療前後における肺野ヨードマップのヒストグラム解析

    大田 英揮, 高木 英誠, 冨永 循哉, 高瀬 圭, 杉村 宏一郎, 佐藤 遙, 高木 英誠

    Japanese Journal of Radiology　37　(Suppl.)　3-3　2019/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  142. Pulmonary Lymphatic Perfusion Syndrome. International-journal Peer-reviewed

    Hirano T, Fujino N, Takase K, Ota H, Tanaka R, Saito R, Suzuki A, Okutomo K, Sato T, Kageyama S, Tamada T, Sugiura H, Ichinose M

    American journal of respiratory and critical care medicine　199　(4)　529-530　2019/02

    DOI： 10.1164/rccm.201806-1125IM 　

    ISSN： 1073-449X

  143. Efficacy of 4'-[methyl-11C] thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal cancer: a pilot study. International-journal Peer-reviewed

    Masatoshi Hotta, Ryogo Minamimoto, Kazuhiko Yamada, Kyoko Nohara, Daisuke Soma, Kazuhiko Nakajima, Jun Toyohara, Kei Takase

    EJNMMI research　9　(1)　10-10　2019/01/30

    DOI： 10.1186/s13550-019-0478-9 　

    More details Close

    BACKGROUND: 4'-[Methyl-11C] thiothymidine (4DST) has been introduced as a new cell proliferation imaging PET tracer that incorporates into DNA directly. The aim of this prospective study was to evaluate the efficacy of 4DST PET/CT for predicting responses to neoadjuvant therapy in patients with esophageal cancer comparing with FDG PET/CT. METHODS: Twenty-six patients who had pre- and post-therapeutic 4DST and FDG PET/CT and underwent esophagectomy following neoadjuvant therapy were used for the analysis. Based on pathological findings, patients were divided into two groups: non-responders and responders. The maximum standardized uptake value (SUVmax), metabolic tumor volume, total lesion glycolysis, and total lesion proliferation of the primary lesion were measured for FDG and 4DST PET. RESULTS: The pathological diagnosis revealed 16 responders and 10 non-responders. Non-responders showed significantly higher 4DST post-therapeutic SUVmax (postSUVmax) than responders, whereas FDG postSUVmax showed no statistically significant difference (non-responders vs. responders: 4DST, 6.7 vs. 3.3, p = 0.001; FDG, 6.1 vs. 4.5, p = 0.11). Responders showed a greater reduction in percentage changes of 4DST and FDG SUVmax (ΔSUVmax) from baseline to post-therapeutic PET (non-responders vs. responders: 4DST, - 2.9% vs. - 56.7%, p < 0.001; FDG, - 36.3% vs. - 72.6%, p < 0.001). In ROC analysis, ΔSUVmax and postSUVmax with 4DST provided great diagnostic performance for predicting responses (area under the curve: 4DST ΔSUVmax = 0.92, 4DST postSUVmax = 0.88). CONCLUSIONS: 4DST PET/CT has a great potential for predicting pathologic response to neoadjuvant therapy in patients with esophageal cancer; it may be slightly superior to that with FDG PET/CT.

  144. A multicenter trial of extracorporeal cardiac shock wave therapy for refractory angina pectoris: report of the highly advanced medical treatment in Japan. Peer-reviewed

    Yoku Kikuchi, Kenta Ito, Tomohiko Shindo, Kiyotaka Hao, Takashi Shiroto, Yasuharu Matsumoto, Jun Takahashi, Takao Matsubara, Akira Yamada, Yukio Ozaki, Michiaki Hiroe, Kazuo Misumi, Hideki Ota, Kentaro Takanami, Tomomichi Hiraide, Kei Takase, Fumiya Tanji, Yasutake Tomata, Ichiro Tsuji, Hiroaki Shimokawa

    Heart and vessels　34　(1)　104-113　2019/01

    DOI： 10.1007/s00380-018-1215-4 　

    ISSN： 0910-8327

    More details Close

    We have previously demonstrated that cardiac shock wave therapy (CSWT) effectively improves myocardial ischemia through coronary neovascularization both in a porcine model of chronic myocardial ischemia and in patients with refractory angina pectoris (AP). In this study, we further addressed the efficacy and safety of CSWT in a single-arm multicenter study approved as a highly advanced medical treatment by the Japanese Ministry of Health, Labour and Welfare. Fifty patients with refractory AP [mean age 70.9 ± 12.6 (SD) years, M/F 38/12] without the indications of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were enrolled in 4 institutes in Japan. Ischemic myocardial regions in the left ventricle (LV) were identified by drug-induced stress myocardial perfusion imaging (MPI). Shock waves (200 shots/spot at 0.09 mJ/mm2) were applied to 40-60 spots in the ischemic myocardium 3 times in the first week. The patients were followed up for 3 months thereafter. Forty-one patients underwent CSWT and completed the follow-up at 3 months. CSWT markedly improved weekly nitroglycerin use [from 3.5 (IQR 2 to 6) to 0 (IQR 0 to 1)] and the symptoms [Canadian Cardiovascular Society functional class score, from 2 (IQR 2 to 3) to 1 (IQR 1 to 2)] (both P < 0.001). CSWT also significantly improved 6-min walking distance (from 384 ± 91 to 435 ± 122 m, P < 0.05). There were no significant changes in LV ejection fraction evaluated by echocardiography and LV stroke volume evaluated by cardiac magnetic resonance imaging (from 56.3 ± 14.7 to 58.8 ± 12.8%, P = 0.10, and from 52.3 ± 17.4 to 55.6 ± 15.7 mL, P = 0.15, respectively). Percent myocardium ischemia assessed by drug-induced stress MPI tended to be improved only in the treated segments (from 16.0 ± 11.1 to 12.1 ± 16.2%, P = 0.06), although no change was noted in the whole LV. No procedural complications or adverse effects related to the CSWT were noted. These results of the multicenter trial further indicate that CSWT is a useful and safe non-invasive strategy for patients with refractory AP with no options of PCI or CABG.

  145. Time to Face the Nightmare That Has Plagued Neurosurgeons for Years: Memory Impairment from Postsurgery Subcallosal Artery Infarction for Anterior Communicating Artery Aneurysms. International-journal Peer-reviewed

    Mugikura S, Takahashi S, Takase K

    World neurosurgery　121　280-281　2019/01

    DOI： 10.1016/j.wneu.2018.08.224 　

    ISSN： 1878-8750

  146. Correlation between the native lung volume change and postoperative pulmonary function after single lung transplantation for lymphangioleiomyomatosis: Evaluation of lung volume by three-dimensional computed tomography volumetry. International-journal Peer-reviewed

    Suzuki H, Oishi H, Noda M, Watanabe T, Matsuda Y, Tominaga J, Sado T, Sakurada A, Kurosawa H, Takase K, Okada Y

    PloS one　14　(2)　e0210975　2019

    DOI： 10.1371/journal.pone.0210975 　

    More details Close

    PURPOSE: Whereas native lung overinflation has been thought to happen in recipients of single lung transplantation for lymphangioleiomyomatosis because of its increased compliance, there is no study that has reported the details on the change of the native lung volume after single lung transplantation by three-dimensional computed tomography volumetry. The purpose of the present study was to evaluate the lung volume after single lung transplantation for lymphangioleiomyomatosis by three-dimensional computed tomography volumetry and investigate the correlation between the native lung volume change and postoperative pulmonary function. METHODS: We retrospectively reviewed the data of 17 patients who underwent single lung transplantation for lymphangioleiomyomatosis. We defined the ratio of the native lung volume to total lung volume (N/T ratio) as an indicator of overinflation of the native lung. In order to assess changes in the N/T ratio over time, we calculated the rate of change in the N/T ratio which is standardized by the N/T ratio at 1 year after single lung transplantation: rate of change in N/T ratio (%) = {(N/T ratio at a certain year)/(N/T ratio at 1 year)- 1}× 100. RESULTS: We investigated the correlations between the N/T ratio and the pulmonary function test parameters at 1 year and 5 years; however, there was no significant correlation between them. On the other hand, there was a significant negative correlation between the rate of change in the N/T ratio and that in forced expiratory volume in 1 second %predicted (%FEV1) at 5 years after single lung transplantation. CONCLUSION: The single lung transplantation recipients for lymphangioleiomyomatosis showed increased rate of change in the N/T ratio in the long-time course after lung transplantation with the decrease of %FEV1. We expect that these cases will probably cause the overinflation of the native lung in the future.

  147. Influence of renal function and demographic data on intrarenal Doppler ultrasonography. International-journal Peer-reviewed

    Michiaki Abe, Tetsuya Akaishi, Takashi Miki, Mika Miki, Yasuharu Funamizu, Kaori Araya, Kota Ishizawa, Shin Takayama, Kei Takase, Takaaki Abe, Tadashi Ishii, Sadayoshi Ito

    PloS one　14　(8)　e0221244　2019

    DOI： 10.1371/journal.pone.0221244 　

    More details Close

    Intrarenal Doppler ultrasonography is a non-invasive method to evaluate the renal blood flow in patients with renal arterial stenosis as well as chronic kidney diseases (CKD). Until recently, the relationship between ultrasonography findings and CKD stage has not been fully understood. Overall, 162 patients with CKD without apparent renal arterial stenosis were included in this study, and the pulsed-wave Doppler ultrasonography findings were evaluated in terms of the following parameters: peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) at the renal arterial trunk, hilum, segmental, and interlobar regions. Age showed a significant negative correlation with the estimated glomerular filtration rate (eGFR), kidney size, and aortic PSV. Additionally, age showed a significant positive correlation with RI in all 4 regions. The eGFR showed a positive correlation with the aortic PSV and kidney size, but a negative correlation with RI. Both age and eGFR were found to be independently associated with aortic blood flow. On the intrarenal ultrasound, EDV and RI showed stronger correlations with eGFR than PSV, suggesting that the former indices would be better markers of renal function. In particular, the interlobar EDV was found to be the best index that reflects renal function. Although the RI is also a good marker of renal function, it is confounded by age; thus, its utility would be weaker than that of the EDV. In conclusion, intrarenal pulsed-wave Doppler ultrasonography is a useful tool to estimate and evaluate the renal function; the interlobar EDV may be the best index to estimate the effective perfusion and filtration of the kidneys.

  148. 当院における塩化ラジウム(223Ra)の初期経験

    太田 瑛梨, 鎌田 裕基, 外山 由貴, 齋藤 美穂子, 高浪 健太郎, 高瀬 圭, 高橋 紀善, 石川 陽二郎, 山本 貴也, 梅澤 玲, 松下 晴雄, 神宮 啓一

    核医学　55　(1)　37-37　2018/12

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  149. FDG-PETで高集積を呈した稀な腹壁病変の一例

    樋口 慧, 外山 由貴, 前川 由衣, 齋藤 美穂子, 高浪 健太郎, 高瀬 圭, 植松 智海, 佐藤 聡子

    核医学　55　(1)　41-41　2018/12

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  150. 先端巨大症合併膝関節症に対して下垂体手術がもたらす効果 膝関節MRIを用いた22症例の解析

    祢津 昌広, 工藤 正孝, 森本 玲, 手塚 雄太, 小野 美澄, 尾股 慧, 五十嵐 康宏, 常陸 真, 高瀬 圭, 伊藤 貞嘉, 佐藤 文俊

    日本内分泌学会雑誌　94　(3)　873-873　2018/12

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  151. アルドステロン産生腺腫合併例における腎組織障害

    手塚 雄太, 尾形 博子, 森本 玲, 工藤 正孝, 五十嵐 康宏, 高瀬 圭, 荒井 陽一, 笹野 公伸, 伊藤 貞嘉, 佐藤 文俊

    日本内分泌学会雑誌　94　(4)　1572-1572　2018/12

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  152. 当科における転移性副腎腫瘍に対する診療実績

    工藤 正孝, 手塚 雄太, 森本 玲, 祢津 昌広, 五十嵐 康宏, 清治 和将, 高瀬 圭, 山崎 有人, 笹野 公伸, 伊藤 貞嘉, 佐藤 文俊

    日本内分泌学会雑誌　94　(4)　1597-1597　2018/12

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  153. 最新半導体PETにおける上腹部病変への呼吸同期の有用性

    外山 由貴, 高浪 健太郎, 太田 瑛梨, 加賀谷 由里子, 前川 由依, 齊藤 美穂子, 高瀬 圭

    核医学　55　(Suppl.)　S208-S208　2018/11

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  154. Traumatic midline subarachnoid hemorrhage on initial computed tomography as a marker of severe diffuse axonal injury. International-journal Peer-reviewed

    Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi, Kei Takase

    Journal of neurosurgery　129　(5)　1317-1324　2018/11/01

    DOI： 10.3171/2017.6.JNS17466 　

    ISSN： 0022-3085

    More details Close

    OBJECTIVEThe objective of this study was to test the hypothesis that midline (interhemispheric or perimesencephalic) traumatic subarachnoid hemorrhage (tSAH) on initial CT may implicate the same shearing mechanism that underlies severe diffuse axonal injury (DAI).METHODSThe authors enrolled 270 consecutive patients (mean age [± SD] 43 ± 23.3 years) with a history of head trauma who had undergone initial CT within 24 hours and brain MRI within 30 days. Six initial CT findings, including intraventricular hemorrhage (IVH) and tSAH, were used as candidate predictors of DAI. The presence of tSAH was determined at the cerebral convexities, sylvian fissures, sylvian vallecula, cerebellar folia, interhemispheric fissure, and perimesencephalic cisterns. Following MRI, patients were divided into negative and positive DAI groups, and were assigned to a DAI stage: 1) stage 0, negative DAI; 2) stage 1, DAI in lobar white matter or cerebellum; 3) stage 2, DAI involving the corpus callosum; and 4) stage 3, DAI involving the brainstem. Glasgow Outcome Scale-Extended (GOSE) scores were obtained in 232 patients.RESULTSOf 270 patients, 77 (28.5%) had DAI; tSAH and IVH were independently associated with DAI (p < 0.05). Of tSAH locations, midline tSAH was independently associated with both overall DAI and DAI stage 2 or 3 (severe DAI; p < 0.05). The midline tSAH on initial CT had sensitivity of 60.8%, specificity of 81.7%, and positive and negative predictive values of 43.7% and 89.9%, respectively, for severe DAI. When adjusted for admission Glasgow Coma Score, the midline tSAH independently predicted poor GOSE score at both hospital discharge and after 6 months.CONCLUSIONSMidline tSAH could implicate the same shearing mechanism that underlies severe DAI, for which midline tSAH on initial CT is a probable surrogate.

  155. Left Ventricular T1 Mapping during Chemotherapy-Radiation Therapy: Serial Assessment of Participants with Esophageal Cancer. International-journal Peer-reviewed

    Takagi H, Ota H, Umezawa R, Kimura T, Kadoya N, Higuchi S, Sun W, Nakajima Y, Saito M, Komori Y, Jingu K, Takase K

    Radiology　289　(2)　347-354　2018/11

    DOI： 10.1148/radiol.2018172076 　

    ISSN： 0033-8419

    More details Close

    Purpose To assess changes in left ventricular function and tissue composition by using MRI after chemotherapy-radiation therapy in participants with esophageal cancer. Materials and Methods Between January 2013 and April 2015, this prospective study enrolled 24 participants (42% women; mean age, 63 years; range, 49-73 years) scheduled for chemotherapy-radiation therapy. 3.0-T MRI examinations were performed before, at 0.5 year, and at 1.5 years after chemotherapy-radiation therapy. Myocardial native T1, postcontrast T1, and extracellular volume were measured in basal septum (as irradiated areas) and apical lateral wall (as nonirradiated areas). Left ventricular function, prevalence of late gadolinium enhancement, and T1 and extracellular volume values were compared over the follow-up period by using Friedman or Cochran Q tests, followed by Dunn test. Results In 14 participants who were followed up for 1.5 years, native T1 and extracellular volume in the septum were elevated at 0.5 year compared with baseline (1183 msec ± 46 [standard deviation] vs 1257 msec ± 35; 26% ± 3 vs 32% ± 3; adjusted P < .01 for both), but not in the lateral wall. Left ventricular stroke volume index and late gadolinium enhancement changed at 1.5 years compared with baseline (41 mL/m2 ± 11 vs 36 mL/m2 ± 9; P = .046; 7% [one of 14] vs 78% [11 of 14]; P < .01). Other measures of left ventricular function did not change during the follow-up period (P > .10 for all). Conclusion Native T1 and extracellular volume could detect early changes in myocardium at 0.5 year after chemotherapy-radiation therapy, whereas left ventricular stroke volume index and late gadolinium enhancement showed abnormality at 1.5 years. © RSNA, 2018 Online supplemental material is available for this article.

  156. Effects of surgical treatment for acromegaly on knee MRI structural features. Peer-reviewed

    Masahiro Nezu, Masataka Kudo, Ryo Morimoto, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Yasuhiro Igarashi, Shin Hitachi, Kei Takase, Sadayoshi Ito, Fumitoshi Satoh

    Endocrine journal　65　(10)　991-999　2018/10/29

    DOI： 10.1507/endocrj.EJ18-0108 　

    ISSN： 0918-8959

    More details Close

    Acromegalic arthropathy is a common complication of acromegaly and harms the quality of life of the patients even after acromegaly is in long-term remission. A recent study demonstrated by knee MRI the characteristic structural features of acromegalic arthropathy. However, the effects of treatment for acromegaly on such structural features are almost unknown. This study was undertaken to analyze the effects of transsphenoidal surgery (TSS) on acromegalic arthropathy and elucidate whether knee MRI findings are reversible or irreversible. We analyzed 22 patients with acromegaly (63.7% females, median age 58 years) by knee MRI at diagnosis. Out of these 22 patients, 16 who underwent TSS (68.9% female, median age 58 years) were also subjected to knee MRI 2 months after TSS. As for X-ray undetectable findings, MRI detected synovial thickening, bone marrow lesion, ligament injury and meniscus injury in 22.7%, 22.7%, 4.7% and 59.1% of the patients, respectively. With respect to the 16 patients who underwent TSS, clinical and structural improvements were observed respectively in 100%, 66.7% and 66.7% of the patients who showed knee joint pain, synovial thickening and bone marrow lesion before TSS. However, no patient showed structural improvement of meniscus injury after TSS. In acromegalic arthropathy, synovial thickening and bone marrow lesions are reversible while meniscus injury is irreversible. Because all those findings are associated with the exacerbation of arthropathy, they may be therapeutic targets for preventing the progression of arthropathy by endocrinological and orthopedic intervention.

  157. Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy. Peer-reviewed

    Kozumi M, Ota H, Yamamoto T, Umezawa R, Matsushita H, Ishikawa Y, Takahashi N, Matsuura T, Takase K, Jingu K

    European radiology　28　(10)　4296-4305　2018/10

    DOI： 10.1007/s00330-018-5439-6 　

    ISSN： 0938-7994

  158. 抗血栓療法を要する原発性アルドステロン症の臨床的特徴の解明

    工藤 正孝, 森本 玲, 手塚 雄太, 尾股 慧, 白鳥 ベアタ, 五十嵐 康弘, 清治 和将, 高瀬 圭, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　41回　OC05-06　2018/09

    Publisher: (NPO)日本高血圧学会

  159. Rapid Development of New Aneurysms in the Adjacent Pancreatic Arcade Arteries after Urgent Embolization of Pancreaticoduodenal Artery Aneurysms in Cases with Celiac Stenosis. Peer-reviewed

    Hasegawa T, Seiji K, Ota H, Matsuura T, Satani N, Sato T, Takase K

    Journal of vascular and interventional radiology : JVIR　29　(9)　1306-1308.e2　2018/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.jvir.2018.04.003 　

    ISSN： 1051-0443

  160. [Imaging Diagnosis and Interventional Radiology for Thoracic Surgery]. Peer-reviewed

    Takase K

    Kyobu geka. The Japanese journal of thoracic surgery　71　(10)　747-754　2018/09

    ISSN： 0021-5252

  161. 褐色細胞腫患者における心筋T1 mappingを用いたカテコラミン心筋障害の評価

    樋口 慧, 大田 英揮, 手塚 雄太, 祢津 昌広, 森本 玲, 高瀬 圭

    日独医報　63　(1)　81-81　2018/07

    Publisher: バイエル薬品(株)

    ISSN： 0912-0351

  162. Treatment Effect of Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension Quantified by Automatic Comparative Imaging in Computed Tomography Pulmonary Angiography Peer-reviewed

    Zhiwei Zhai, Hideki Ota, Marius Staring, Jan Stolk, Koichiro Sugimura, Kei Takase, Berend C. Stoel

    Investigative Radiology　53　(5)　286-292　2018/05/01

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1097/RLI.0000000000000441 　

    ISSN： 1536-0210 0020-9996

  163. Relationship Between Perforator Infarction and Patient Outcomes After Surgical Treatment of Ruptured Anterior Communicating Artery Aneurysms. Peer-reviewed

    Mugikura S, Fujimura M, Takahashi S, Takase K

    World neurosurgery　113　390-391　2018/05

    DOI： 10.1016/j.wneu.2018.01.161 　

    ISSN： 1878-8750

  164. Renovascular hypertension associated with JAK2 V617F positive myeloproliferative neoplasms treated with angioplasty: 2 cases and literature review. International-journal Peer-reviewed

    Eikan Mishima, Takehiro Suzuki, Yoichi Takeuchi, Kazumasa Seiji, Noriko Fukuhara, Kei Takase, Hideo Harigae, Takaaki Abe, Sadayoshi Ito

    Journal of clinical hypertension (Greenwich, Conn.)　20　(4)　798-804　2018/04

    DOI： 10.1111/jch.13257 　

    ISSN： 1524-6175

    More details Close

    Myeloproliferative neoplasms (MPNs) with Janus kinase 2 (JAK2) mutation are associated with a high risk for occlusive vascular diseases. We report 2 cases of renovascular hypertension associated with JAK2 V617F mutation-positive MPNs and provide a literature review. In Case 1, a 63-year-old woman had resistant hypertension, massive proteinuria, and erythrocytosis. Evaluations revealed right renal artery stenosis causing renovascular hypertension and polycythemia vera with JAK2 V617F mutation. Renin-angiotensin system inhibitors and subsequent angioplasty controlled the blood pressure and the proteinuria resolved. In Case 2, a 74-year-old woman had resistant hypertension and thrombocytosis. Evaluations confirmed left renal artery stenosis and essential thrombocythemia with JAK2 V617F. Angioplasty cured the hypertension. A literature review of 18 cases revealed the following as the most common characteristics of MPN-associated renovascular hypertension: manifests primarily in women; is associated with untreated polycythemia vera and essential thrombocythemia, concomitant leukocytosis, and JAK2 mutation positivity; and is responsive to angioplasty. This report demonstrates that JAK2 mutation-positive MPNs are a less common but important underlying cause of adult renovascular hypertension.

  165. Anthracycline系による治療を受けた癌患者の管理における心臓MRIの有用性 腫瘍循環器学の進歩(Usefulness of Cardiac MRI in the Management of Cancer Patients Treated with Anthracyclines: Progress in Cardiooncology)

    照井 洋輔, 杉村 宏一郎, 大田 英揮, 佐藤 遥, 後岡 広太郎, 建部 俊介, 青木 竜男, 山本 沙織, 神津 克也, 紺野 亮, 高瀬 圭, 下川 宏明

    日本循環器学会学術集会抄録集　82回　OJ02-4　2018/03

    Publisher: (一社)日本循環器学会

  166. 右鼠径部-大陰唇の膨隆を呈し、臨床的に鼠径ヘルニアや水腫が疑われた小児症例

    樋口 慧, 北見 昌広, 齋藤 美穂子, 高瀬 圭, 西 功太郎, 袴塚 崇, 古田 明美

    Japanese Journal of Radiology　36　(Suppl.)　14-14　2018/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  167. 縦隔の悪性Solitary Fibrous Tumorの1例

    村中 美千帆, 冨永 循哉, 高瀬 圭, 桜田 晃, 齊藤 涼子

    Japanese Journal of Radiology　36　(Suppl.)　16-16　2018/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  168. Usefulness of the S–O clip for gastric endoscopic submucosal dissection (with video) Peer-reviewed

    Rintaro Hashimoto, Dai Hirasawa, Tomoyuki Iwaki, Hajime Yamaoka, Kousuke Nihei, Ippei Tanaka, Akimichi Chonan, Kei Takase

    Surgical Endoscopy and Other Interventional Techniques　32　(2)　908-914　2018/02/01

    Publisher: Springer New York LLC

    DOI： 10.1007/s00464-017-5765-9 　

    ISSN： 1432-2218 0930-2794

  169. Subcallosal and Heubner artery infarcts following surgical repair of an anterior communicating artery aneurysm: a causal relationship with postoperative amnesia and long-term outcome Peer-reviewed

    Shunji Mugikura, Hirokazu Kikuchi, Miki Fujimura, Etsuro Mori, Shoki Takahashi, Kei Takase

    Japanese Journal of Radiology　36　(2)　81-89　2018/02/01

    Publisher: Springer Tokyo

    DOI： 10.1007/s11604-017-0703-2 　

    ISSN： 1867-108X 1867-1071

  170. Coronary Adventitial and Perivascular Adipose Tissue Inflammation in Patients With Vasospastic Angina. International-journal Peer-reviewed

    Kazuma Ohyama, Yasuharu Matsumoto, Kentaro Takanami, Hideki Ota, Kensuke Nishimiya, Jun Sugisawa, Satoshi Tsuchiya, Hirokazu Amamizu, Hironori Uzuka, Akira Suda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Hiroaki Shimokawa

    Journal of the American College of Cardiology　71　(4)　414-425　2018/01/30

    DOI： 10.1016/j.jacc.2017.11.046 　

    ISSN： 0735-1097

    More details Close

    BACKGROUND: Recent studies suggested that perivascular components, such as perivascular adipose tissue (PVAT) and adventitial vasa vasorum (VV), play an important role as a source of various inflammatory mediators in cardiovascular disease. OBJECTIVES: The authors tested their hypothesis that coronary artery spasm is associated with perivascular inflammation in patients with vasospastic angina (VSA) using 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). METHODS: This study prospectively examined 27 consecutive VSA patients with acetylcholine-induced diffuse spasm in the left anterior descending artery (LAD) and 13 subjects with suspected angina but without organic coronary lesions or coronary spasm. Using CT coronary angiography and electrocardiogram-gated 18F-FDG PET/CT, coronary PVAT volume and coronary perivascular FDG uptake in the LAD were examined. In addition, adventitial VV formation in the LAD was examined with optical coherence tomography, and Rho-kinase activity was measured in circulating leukocytes. RESULTS: Patient characteristics were comparable between the 2 groups. CT coronary angiography and ECG-gated 18F-FDG PET/CT showed that coronary PVAT volume and coronary perivascular FDG uptake significantly increased in the VSA group compared with the non-VSA group. Furthermore, optical coherence tomography showed that adventitial VV formation significantly increased in the VSA group compared with the non-VSA group, as did Rho-kinase activity. Importantly, during the follow-up period with medical treatment, both coronary perivascular FDG uptake and Rho-kinase activity significantly decreased in the VSA group. CONCLUSIONS: These results provide the first evidence that coronary spasm is associated with inflammation of coronary adventitia and PVAT, where 18F-FDG PET/CT could be useful for disease activity assessment. (Morphological and Functional Change of Coronary Perivascular Adipose Tissue in Vasospastic Angina [ADIPO-VSA Trial]; UMIN000016675).

  171. Image quality and radiation dose of low-tube-voltage CT with reduced contrast media for right adrenal vein imaging. International-journal Peer-reviewed

    Yuki Takahashi, Hideki Ota, Kensuke Omura, Yutaka Dendo, Katharina Otani, Tomonori Matsuura, Masahiro Kitami, Kazumasa Seiji, Yuta Tezuka, Masahiro Nezu, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

    European journal of radiology　98　150-157　2018/01

    DOI： 10.1016/j.ejrad.2017.11.017 　

    ISSN： 0720-048X

    More details Close

    OBJECTIVES: To compare image quality and radiation dose of right adrenal vein (RAV) imaging computed tomography (CT) among conventional, low kV, and low kV with reduced contrast medium protocols. METHODS: One-hundred-and-twenty patients undergoing adrenal CT were randomly assigned to one of three protocols: contrast dose of 600mgI/kg at 120-kV tube voltage setting (600-120 group), 600mgI/kg at 80kV (600-80 group), and 360mgI/kg at 80kV (360-80 group). Iterative reconstruction was used for 80-kV groups. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the RAV and size-specific dose estimates (SSDE) were measured. Three radiologists evaluated 4-point visualisation scores of RAV by consensus reading. RESULTS: The RAV detectability was 95%, 97.2%, and 97.3% for 600-120, 600-80, and 360-80 groups, respectively (p=1.000). Visualisation scores were not significantly different among the groups (p=0.152). There were no significant differences in CNR or SNR between the 600-120 and 360-80 groups. SSDE of the 360-80 group was significantly lower than that of the 600-120 group (5.86mGy±1.44 vs. 7.27mGy±1.81, p<0.001). CONCLUSIONS: 80-kV scans with 360 mgI/kg contrast media showed comparable detectability of RAV to conventional scans, while reducing 19% of SSDE.

  172. Influence of Uncertain Anticipation on Brain Responses to Aversive Rectal Distension in Patients With Irritable Bowel Syndrome Peer-reviewed

    Michiko Kano, Tomohiko Muratsubaki, Joe Morishita, Keiji Kono, Shunji Mugikura, Kei Takase, Huynh Giao Ly, Patrick Dupont, Lukas Van Oudenhove, Shin Fukudo

    PSYCHOSOMATIC MEDICINE　79　(9)　988-999　2017/11

    DOI： 10.1097/PSY.0000000000000484 　

    ISSN： 0033-3174

    eISSN： 1534-7796

  173. Fear of linear gadolinium-based contrast agents and the Japanese radiologist's choice Peer-reviewed

    Shunji Mugikura, Kei Takase

    JAPANESE JOURNAL OF RADIOLOGY　35　(11)　695-696　2017/11

    DOI： 10.1007/s11604-017-0682-3 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  174. The re-emerging importance of radiologic-pathologic correlation in reaching the pathology diagnosis Peer-reviewed

    Monica Sze Man Chan, Ryoko Saito, Kei Takase, Yasuhiro Nakamura, Hironobu Sasano

    PATHOLOGY INTERNATIONAL　67　(11)　537-538　2017/11

    DOI： 10.1111/pin.12599 　

    ISSN： 1320-5463

    eISSN： 1440-1827

  175. Clinical utility of texture analysis of 18F-FDG PET/CT in patients with Stage I lung cancer treated with stereotactic body radiotherapy Peer-reviewed

    Kazuya Takeda, Kentaro Takanami, Yuko Shirata, Takaya Yamamoto, Noriyoshi Takahashi, Kengo Ito, Kei Takase, Keiichi Jingu

    JOURNAL OF RADIATION RESEARCH　58　(6)　862-869　2017/11

    DOI： 10.1093/jrr/rrx050 　

    ISSN： 0449-3060

    eISSN： 1349-9157

  176. 無症候性原発性副甲状腺機能亢進症の一例

    手塚 雄太, 森本 玲, 祢津 昌広, 五十嵐 康宏, 工藤 正孝, 高瀬 圭, 中島 範昭, 山崎 有人, 笹野 公伸, 伊藤 貞嘉, 佐藤 文俊

    日本内分泌学会雑誌　93　(2)　565-565　2017/10

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  177. Selective embolization therapy for intrarenal artery stenosis causing renovascular hypertension: Efficacy and follow-up renal imaging Peer-reviewed

    Eikan Mishima, Takehiro Suzuki, Kazumasa Seiji, Yasutoshi Akiyama, Hideki Ota, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF CLINICAL HYPERTENSION　19　(10)　1028-1031　2017/10

    DOI： 10.1111/jch.13040 　

    ISSN： 1524-6175

    eISSN： 1751-7176

  178. Native T1値と細胞外容積分画を用いた放射線心筋障害の評価

    高木 英誠, 大田 英揮, 梅沢 玲, 神宮 啓一, 高瀬 圭

    日独医報　62　(1)　82-82　2017/09

    Publisher: バイエル薬品(株)

    ISSN： 0912-0351

  179. Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome Peer-reviewed

    Michiko Kano, Tomohiko Muratsubaki, Lukas Van Oudenhove, Joe Morishita, Makoto Yoshizawa, Keiji Kohno, Mao Yagihashi, Yukari Tanaka, Shunji Mugikura, Patrick Dupont, Huynh Giao Ly, Kei Takase, Motoyori Kanazawa, Shin Fukudo

    SCIENTIFIC REPORTS　7　(1)　12425　2017/09

    DOI： 10.1038/s41598-017-09635-x 　

    ISSN： 2045-2322

  180. Ischemic White Matter Lesions Associated With Medullary Arteries: Classification of MRI Findings Based on the Anatomic Arterial Distributions Peer-reviewed

    Toshiaki Akashi, Shoki Takahashi, Shunji Mugikura, Shiho Sato, Takaki Murata, Atsushi Umetsu, Kei Takase

    AMERICAN JOURNAL OF ROENTGENOLOGY　209　(3)　W160-W168　2017/08

    DOI： 10.2214/AJR.16.17231 　

    ISSN： 0361-803X

    eISSN： 1546-3141

  181. For Whom Should We Write a Radiology Report, an Attending Physician or a Patient? Peer-reviewed

    Shunji Mugikura, Keisei Fujimori, Kei Takase

    AMERICAN JOURNAL OF ROENTGENOLOGY　209　(3)　W199-W199　2017/08

    DOI： 10.2214/AJR.17.18150 　

    ISSN： 0361-803X

    eISSN： 1546-3141

  182. Further Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan. Peer-reviewed

    Mugikura S, Fujimura M, Takahashi S, Takase K

    Radiology　284　(1)　301-303　2017/07

    DOI： 10.1148/radiol.2017170252 　

    ISSN： 0033-8419

  183. 二次性高血圧を見逃さない 原発性アルドステロン症診断治療のUpdate

    佐藤 文俊, 森本 玲, 手塚 雄太, 尾股 慧, 祢津 昌広, 小野 美澄, 岩倉 芳倫, 五十嵐 康宏, 工藤 正孝, 高瀬 圭, 笹野 公伸, 伊藤 貞嘉

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　6回　103-103　2017/05

    Publisher: (NPO)日本高血圧学会

  184. 副腎静脈サンプリングにて片側副腎摘除の適応と判定したが、最終的に薬物療法での加療を選択された症例についての報告

    工藤 正孝, 森本 玲, 岩倉 芳倫, 小野 美澄, 手塚 雄太, 祢津 昌広, 五十嵐 康宏, 清治 和将, 高瀬 圭, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　6回　156-156　2017/05

    Publisher: (NPO)日本高血圧学会

  185. 生体肝移植後の肝静脈血栓閉塞に対し、バルーン拡張と経カテーテルウロキナーゼ投与が奏功した一例

    円城寺 康宏, 大田 英揮, 清治 和将, 高瀬 圭, 横沢 友樹, 中西 史, 宮城 重人

    IVR: Interventional Radiology　32　(Suppl.)　286-286　2017/04

    Publisher: (一社)日本インターベンショナルラジオロジー学会

    ISSN： 1340-4520

    eISSN： 2185-6451

  186. Coil embolization of left ventricular outflow tract pseudoaneurysms: techniques and 5-year results Peer-reviewed

    Hideki Ota, Yoshiaki Morita, Yoshikatsu Saiki, Kei Takase

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY　24　(4)　631-633　2017/04

    DOI： 10.1093/icvts/ivw394 　

    ISSN： 1569-9293

    eISSN： 1569-9285

  187. 早期治療にて日和見感染症を管理し得たCushing病の一例

    手塚 雄太, 森本 玲, 工藤 正孝, 祢津 昌広, 小野 美澄, 五十嵐 康宏, 高瀬 圭, 井下 尚子, 山田 正三, 伊藤 貞嘉, 佐藤 文俊

    ACTH RELATED PEPTIDES　28　8-10　2017/03

    Publisher: 間脳・下垂体・副腎系研究会

    ISSN： 1340-4512

  188. Anderson-Fabry病の患者における心臓病変に対する新たな診断戦略(Novel Diagnostic Strategy for Cardiac Involvement in Patients with Anderson-Fabry Disease)

    山本 沙織, 杉村 宏一郎, 鈴木 秀明, 建部 俊介, 青木 竜男, 矢尾板 信裕, 佐藤 遥, 神津 克也, 大田 英揮, 高浪 健太郎, 高瀬 圭, 佐藤 公雄, 下川 宏明

    日本循環器学会学術集会抄録集　81回　OJ-053　2017/03

    Publisher: (一社)日本循環器学会

  189. Quantitative Analysis of Contrast-Enhanced Ultrasound Imaging in Invasive Breast Cancer: A Novel Technique to Obtain Histopathologic Information of Microvessel Density Peer-reviewed

    Naoko Mori, Shunji Mugikura, Shoki Takahashi, Koichi Ito, Chiaki Takasawa, Li Li, Minoru Miyashita, Atsuko Kasajima, Yu Mori, Takanori Ishida, Tetsuya Kodama, Kei Takase

    Ultrasound in Medicine and Biology　43　(3)　607-614　2017/03/01

    DOI： 10.1016/j.ultrasmedbio.2016.11.009 　

    ISSN： 0301-5629

    eISSN： 1879-291X

  190. Anatomical Variations of the Right Adrenal Vein Concordance Between Multidetector Computed Tomography and Catheter Venography Peer-reviewed

    Kensuke Omura, Hideki Ota, Yuuki Takahashi, Tomonori Matsuura, Kazumasa Seiji, Yoichi Arai, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

    HYPERTENSION　69　(3)　428-+　2017/03

    DOI： 10.1161/HYPERTENSIONAHA.116.08375 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  191. 数年を経て確定診断に至った骨原発悪性リンパ腫の3例

    木下 知, 常陸 真, 榊原 宏幸, 森下 陽平, 高橋 祐輝, 野村 脩子, 加賀谷 由里子, 長谷川 哲也, 佐藤 嘉尚, 佐藤 友美, 嶋内 亜希子, 森 菜緒子, 松浦 智徳, 大田 英揮, 北見 昌広, 冨永 循哉, 清治 和将, 高瀬 圭

    Japanese Journal of Radiology　35　(Suppl.)　1-1　2017/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  192. 肝腫瘍への定位照射を目的としたCTガイド下金マーカー留置術における合併症の検討

    高橋 祐輝, 松浦 智徳, 榊原 宏幸, 森下 陽平, 加賀谷 由里子, 野村 脩子, 木下 知, 長谷川 哲也, 佐藤 嘉尚, 嶋内 亜希子, 森 菜緒子, 大田 英揮, 常陸 真, 北見 昌広, 冨永 循哉, 清治 和将, 高瀬 圭, 神宮 啓一, 小川 芳弘

    Japanese Journal of Radiology　35　(Suppl.)　2-2　2017/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  193. 自然縮小した胸腺腫の1例

    大山 翼, 袴塚 崇, 榊原 宏幸, 森下 陽平, 伊藤 幸, 高橋 祐輝, 野村 脩子, 大村 健介, 前川 由衣, 加賀谷 由里子, 長谷川 哲也, 木下 知, 佐藤 嘉尚, 外山 由貴, 冨永 循哉, 高瀬 圭

    Japanese Journal of Radiology　35　(Suppl.)　8-8　2017/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  194. 冠状動脈-肺動脈瘻に合併した動脈瘤に対する塞栓術の1例

    榊原 宏幸, 大田 英揮, 伊藤 幸, 森下 陽平, 高橋 祐輝, 大村 健介, 野村 脩子, 加賀谷 由里子, 前川 由依, 木下 知, 長谷川 哲也, 佐藤 嘉尚, 外山 由貴, 佐藤 友美, 嶋内 亜希子, 森 菜緒子, 松浦 智徳, 北見 昌広, 常陸 真, 齊藤 美穂子, 冨永 循哉, 清治 和将, 高瀬 圭

    Japanese Journal of Radiology　35　(Suppl.)　8-8　2017/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  195. 胆嚢悪性リンパ腫の1例

    森下 陽平, 長谷川 哲也, 伊藤 幸, 榊原 宏幸, 高橋 祐輝, 大村 健介, 野村 脩子, 加賀谷 由里子, 前川 由依, 木下 知, 佐藤 嘉尚, 外山 由貴, 佐藤 友美, 嶋内 亜希子, 森 菜緒子, 松浦 智徳, 大田 英揮, 北見 昌広, 常陸 真, 齊藤 美穂子, 冨永 循哉, 清治 和将, 高瀬 圭

    Japanese Journal of Radiology　35　(Suppl.)　10-10　2017/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  196. Endovascular Treatment of Hepatic Artery Pseudoaneurysm after Pancreaticoduodenectomy: Risk Factors Associated with Mortality and Complications Peer-reviewed

    Tetsuya Hasegawa, Hideki Ota, Tomonori Matsuura, Kazumasa Seiji, Shunji Mugikura, Fuyuhiko Motoi, Michiaki Unno, Kei Takase

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　28　(1)　50-59　2017/01

    DOI： 10.1016/j.jvir.2016.04.004 　

    ISSN： 1051-0443

    eISSN： 1535-7732

  197. Focal Reduction in Cardiac I-123-Metaiodobenzylguanidine Uptake in Patients With Anderson-Fabry Disease Peer-reviewed

    Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Shunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Haruka Sato, Katuya Kozu, Hideki Ota, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

    CIRCULATION JOURNAL　80　(12)　2550-+　2016/12

    DOI： 10.1253/circj.CJ-16-0690 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  198. 重症高Ca血症の是正に難渋した原発性副甲状腺機能亢進症の一例

    手塚 雄太, 森本 玲, 小野 美澄, 岩倉 芳倫, 工藤 正孝, 祢津 昌広, 尾股 慧, 五十嵐 康宏, 中島 範昭, 高瀬 圭, 山崎 有人, 笹野 公伸, 伊藤 貞嘉, 佐藤 文俊

    日本内分泌学会雑誌　92　(2)　507-507　2016/10

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  199. 透析中の血圧管理に難渋した副腎内傍神経節腫合併血液透析症例

    手塚 雄太, 森本 玲, 秋保 真穂, 藤倉 恵美, 祢津 昌広, 小野 美澄, 五十嵐 康宏, 工藤 正孝, 高瀬 圭, 荒井 陽一, 山崎 有人, 笹野 公伸, 伊藤 貞嘉, 佐藤 文俊

    日本内分泌学会雑誌　92　(2)　521-521　2016/10

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  200. T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus Peer-reviewed

    Shiho Sato, Masaki Iwasaki, Hiroyoshi Suzuki, Shunji Mugikura, Kazutaka Jin, Teiji Tominaga, Kei Takase, Shoki Takahashi, Nobukazu Nakasato

    EPILEPSY RESEARCH　126　1-9　2016/10

    DOI： 10.1016/j.eplepsyres.2016.06.001 　

    ISSN： 0920-1211

    eISSN： 1872-6844

  201. わずかな領域の腎虚血が高血圧の原因となった分枝型腎血管性高血圧の1例 高血圧の病態形成に限局性腎虚血が与える影響

    三島 英換, 鈴木 健弘, 菊地 晃一, 島 久登, 清治 和将, 高瀬 圭, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　39回　390-390　2016/09

    Publisher: (NPO)日本高血圧学会

  202. 腎動脈狭窄による腎虚血診断のためのDiffusion-weighted MRIの有用性と臨床応用性の検討

    三島 英換, 大田 英揮, 鈴木 健弘, 菊地 晃一, 島 久登, 橋本 潤一郎, 高瀬 圭, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　39回　358-358　2016/09

    Publisher: (NPO)日本高血圧学会

  203. 片側性原発性アルドステロン症における術後アウトカムの検討 lateralization indexによる層別化

    森本 玲, 小野 美澄, 祢津 昌広, 尾股 慧, 手塚 雄太, 五十嵐 康宏, 工藤 正孝, 高瀬 圭, 荒井 陽一, 笹野 公伸, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　39回　368-368　2016/09

    Publisher: (NPO)日本高血圧学会

  204. Dual-energy CT to estimate clinical severity of chronic thromboembolic pulmonary hypertension: Comparison with invasive right heart catheterization Peer-reviewed

    Hidenobu Takagi, Hideki Ota, Koichiro Sugimura, Katharina Otani, Junya Tominaga, Tatsuo Aoki, Shunsuke Tatebe, Masanobu Miura, Saori Yamamoto, Haruka Sato, Nobuhiro Yaoita, Hideaki Suzuki, Hiroaki Shimokawa, Kei Takase

    EUROPEAN JOURNAL OF RADIOLOGY　85　(9)　1574-1580　2016/09

    DOI： 10.1016/j.ejrad.2016.06.010 　

    ISSN： 0720-048X

    eISSN： 1872-7727

  205. Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension Peer-reviewed

    Haruka Sato, Hideki Ota, Koichiro Sugimura, Tatsuo Aoki, Shunsuke Tatebe, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Hideaki Suzuki, Kimio Satoh, Kei Takase, Hiroaki Shimokawa

    CIRCULATION JOURNAL　80　(6)　1470-1477　2016/06

    DOI： 10.1253/circj.CJ-15-1187 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  206. 中心静脈路確保困難に対しalternative central vein routeアプローチで中心静脈カテーテルを留置した3例

    榊原 宏幸, 清治 和将, 大山 翼, 森下 陽平, 高橋 祐輝, 野村 脩子, 加賀谷 由里子, 長谷川 哲也, 佐藤 嘉尚, 佐藤 友美, 松浦 智徳, 大田 英揮, 冨永 循哉, 高瀬 圭

    IVR: Interventional Radiology　31　(Suppl.)　160-160　2016/04

    Publisher: (一社)日本インターベンショナルラジオロジー学会

    ISSN： 1340-4520

    eISSN： 2185-6451

  207. Detection of Segmental Renal Ischemia by Diffusion-Weighted Magnetic Resonance Imaging: Clinical Utility for Diagnosis of Renovascular Hypertension Peer-reviewed

    Eikan Mishima, Koichi Kikuchi, Hideki Ota, Yasutoshi Akiyama, Takehiro Suzuki, Kazumasa Seiji, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF CLINICAL HYPERTENSION　18　(4)　364-365　2016/04

    DOI： 10.1111/jch.12675 　

    ISSN： 1524-6175

    eISSN： 1751-7176

  208. Association between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy: Prospective study using I-123 BMIPP SPECT/CT Peer-reviewed

    Kentaro Takanami, Akira Arai, Rei Umezawa, Takashi Takeuchi, Noriynki Kadoya, Yasuyuki Taki, Keiichi Jingu, Kei Takase

    RADIOTHERAPY AND ONCOLOGY　119　(1)　77-83　2016/04

    DOI： 10.1016/j.radonc.2016.01.024 　

    ISSN： 0167-8140

  209. Dynamic multidetector CT and non-contrast-enhanced MR for right adrenal vein imaging: comparison with catheter venography in adrenal venous sampling Peer-reviewed

    Hideki Ota, Kazumasa Seiji, Masahiro Kawabata, Nozomi Satani, Kei Omata, Yoshikiyo Ono, Yoshitsugu Iwakura, Ryo Morimoto, Tomonori Matsuura, Masataka Kudo, Junya Tominaga, Fumitoshi Satoh, Sadayoshi Ito, Kei Takase

    EUROPEAN RADIOLOGY　26　(3)　622-630　2016/03

    DOI： 10.1007/s00330-015-3872-3 　

    ISSN： 0938-7994

    eISSN： 1432-1084

  210. Impact of Small Renal Ischemia in Hypertension Development: Renovascular Hypertension Caused by Small Branch Artery Stenosis Peer-reviewed

    Eikan Mishima, Junichiro Hashimoto, Yasutoshi Akiyama, Hisato Shima, Kazumasa Seiji, Kei Takase, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF CLINICAL HYPERTENSION　18　(3)　248-249　2016/03

    DOI： 10.1111/jch.12661 　

    ISSN： 1524-6175

    eISSN： 1751-7176

  211. Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism Peer-reviewed

    Yoshitsugu Iwakura, Sadayoshi Ito, Ryo Morimoto, Masataka Kudo, Yoshikiyo Ono, Masahiro Nezu, Kei Takase, Kazumasa Seiji, Shigeto Ishidoya, Yoichi Arai, Yasuharu Funamizu, Takashi Miki, Yasuhiro Nakamura, Hironobu Sasano, Fumitoshi Satoh

    HYPERTENSION　67　(3)　654-660　2016/03

    DOI： 10.1161/HYPERTENSIONAHA.115.05924 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  212. Lipomatous hypertrophy of the interatrial septumが疑われた症例

    前川 由依, 外山 由貴, 荒井 晃, 高浪 健太郎, 高瀬 圭, 瀧 靖之

    核医学　53　(1)　509-509　2016/02

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  213. 弓部置換術後遠隔期リークとの鑑別を要した人工血管周囲血腫の1例

    大村 健介, 大田 英揮, 高瀬 圭, 松浦 智徳, 常陸 真, 冨永 循哉, 清治 和将, 田村 亮

    Japanese Journal of Radiology　34　(Suppl.)　14-14　2016/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  214. 嗄声を主訴に多発リンパ節転移が発見され、FDG-PET/CTにて指摘した前立腺癌の1例

    寺尾 千秋, 下村 英雄, 戸恒 智子, 舘脇 康子, 阿部 十也, 武藤 達士, 瀧 靖之, 荒井 晃, 高浪 健太郎, 高瀬 圭

    核医学　53　(1)　512-512　2016/02

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  215. 著明な腹水貯留を呈した原発不明癌に対してFDG-PET/CTを施行した一例

    小林 洋樹, 下村 英雄, 舘脇 康子, 阿部 十也, 武藤 達士, 瀧 靖之, 荒井 晃, 高浪 健太郎, 高瀬 圭

    核医学　53　(1)　512-512　2016/02

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  216. タルクによる胸膜癒着術を施行した1症例におけるFDG-PET所見

    榊原 宏幸, 荒井 晃, 高浪 健太郎, 高瀬 圭, 戸恒 智子, 下村 英雄, 舘脇 康子, 武藤 達士, 瀧 靖之, 渡辺 みか, 井上 健太郎

    核医学　53　(1)　568-568　2016/02

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  217. Erratum to: Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer [Eur Radiol, DOI 10.1007/s00330-015-3847-4] Peer-reviewed

    Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

    European Radiology　26　(2)　340-341　2016/02/01

    Publisher: Springer Verlag

    DOI： 10.1007/s00330-015-3888-8 　

    ISSN： 1432-1084 0938-7994

    eISSN： 1432-1084

  218. Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer Peer-reviewed

    Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

    EUROPEAN RADIOLOGY　26　(2)　331-339　2016/02

    DOI： 10.1007/s00330-015-3847-4 　

    ISSN： 0938-7994

    eISSN： 1432-1084

  219. Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer (vol 26, pg 331, 2016) Peer-reviewed

    Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

    EUROPEAN RADIOLOGY　26　(2)　340-341　2016/02

    DOI： 10.1007/s00330-015-3888-8 　

    ISSN： 0938-7994

    eISSN： 1432-1084

  220. Morphology evaluation of nonmass enhancement on breast MRI: Effect of a three-step interpretation model for readers' performances and biopsy recommendations Peer-reviewed

    Akiko Shimauchi, Hideki Ota, Youichi Machida, Tamiko Yoshida, Nozomi Satani, Naoko Mori, Kei Takase, Mitsuhiro Tozaki

    EUROPEAN JOURNAL OF RADIOLOGY　85　(2)　480-488　2016/02

    DOI： 10.1016/j.ejrad.2015.11.043 　

    ISSN： 0720-048X

    eISSN： 1872-7727

  221. Canadian CT head rule and New Orleans Criteria in mild traumatic brain injury: comparison at a tertiary referral hospital in Japan Peer-reviewed

    Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Kei Takase, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

    SPRINGERPLUS　5　176　2016/02

    DOI： 10.1186/s40064-016-1781-9 　

    ISSN： 2193-1801

  222. Intra-adrenal Aldosterone Secretion: Segmental Adrenal Venous Sampling for Localization Peer-reviewed

    Nozomi Satani, Hideki Ota, Kazumasa Seiji, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Masahiro Nezu, Kei Omata, Sadayoshi Ito, Fumitoshi Satoh, Kei Takase

    RADIOLOGY　278　(1)　265-274　2016/01

    DOI： 10.1148/radiol.2015142159 　

    ISSN： 0033-8419

  223. Pulmonary Arterial Hypertension Associated with Congenital Portosystemic Shunts Treated with Transcatheter Embolization and Pulmonary Vasodilators Peer-reviewed

    Haruka Sato, Masanobu Miura, Nobuhiro Yaoita, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Kimio Satoh, Hideki Ota, Kei Takase, Koichiro Sugimura, Hiroaki Shimokawa

    INTERNAL MEDICINE　55　(17)　2429-2432　2016

    DOI： 10.2169/internalmedicine.55.6557 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  224. Utility of diffusion tensor imaging parameters for diagnosis of hemimegalencephaly Peer-reviewed

    Tomomi Oikawa, Yasuko Tatewaki, Takaki Murata, Yumiko Kato, Shunji Mugikura, Kei Takase, Shoki Takahashi

    Neuroradiology Journal　28　(6)　628-633　2015/12/01

    Publisher: SAGE Publications Inc.

    DOI： 10.1177/1971400915609334 　

    ISSN： 1971-4009

  225. Identifying the Adamkiewicz artery using 3-T time-resolved magnetic resonance angiography: its role in addition to multidetector computed tomography angiography Peer-reviewed

    Hidenobu Takagi, Hideki Ota, Yutaka Natsuaki, Yoshiaki Komori, Koki Ito, Yoshikatsu Saiki, Kei Takase

    JAPANESE JOURNAL OF RADIOLOGY　33　(12)　749-756　2015/12

    DOI： 10.1007/s11604-015-0490-6 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  226. 二管球CTによる肺灌流画像を用いた慢性血栓塞栓性肺高血圧症の重症度評価

    高木 英誠, 大田 英揮, 佐藤 遙, 三浦 正暢, 青木 竜男, 建部 俊介, 杉村 宏一郎, 冨永 循哉, 下川 宏明, 高瀬 圭

    日独医報　60　(2)　238-238　2015/11

    Publisher: バイエル薬品(株)

    ISSN： 0912-0351

  227. A comparative study of the extent of cerebral microvascular injury following whole-brain irradiation versus reduced-field irradiation in long-term survivors of intracranial germ cell tumors Peer-reviewed

    Li Li, Shunji Mugikura, Toshihiro Kumabe, Takaki Murata, Etsuro Mori, Kei Takase, Keiichi Jingu, Shoki Takahashi

    RADIOTHERAPY AND ONCOLOGY　117　(2)　302-307　2015/11

    DOI： 10.1016/j.radonc.2015.09.017 　

    ISSN： 0167-8140

  228. A Case of Apparent Lung Adenocarcinoma Size Reduction During Steroid Therapy Peer-reviewed

    Yoshinao Sato, Katsunori Oikado, Junya Tominaga, Akira Sakurada, Ryoko Saito, Kei Takase

    JOURNAL OF THORACIC IMAGING　30　(6)　W80-W81　2015/11

    DOI： 10.1097/RTI.0000000000000178 　

    ISSN： 0883-5993

    eISSN： 1536-0237

  229. Is there a role for segmental adrenal venous sampling and adrenal sparing surgery in patients with primary aldosteronism? Peer-reviewed

    Fumitoshi Satoh, Ryo Morimoto, Kazumasa Seiji, Nozomi Satani, Hideki Ota, Yoshitsugu Iwakura, Yoshikiyo Ono, Masataka Kudo, Masahiro Nezu, Kei Omata, Yuta Tezuka, Yoshihide Kawasaki, Shigeto Ishidoya, Yoichi Arai, Kei Takase, Yasuhiro Nakamura, Keely McNamara, Hironobu Sasano, Sadayoshi Ito

    EUROPEAN JOURNAL OF ENDOCRINOLOGY　173　(4)　465-477　2015/10

    DOI： 10.1530/EJE-14-1161 　

    ISSN： 0804-4643

    eISSN： 1479-683X

  230. Posterior reversible encephalopathy syndrome treated with renin-angiotensin system blockade Peer-reviewed

    Eikan Mishima, Junichiro Hashimoto, Yasutoshi Akiyama, Kazumasa Seiji, Kei Takase, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF THE NEUROLOGICAL SCIENCES　355　(1-2)　219-221　2015/08

    DOI： 10.1016/j.jns.2015.06.007 　

    ISSN： 0022-510X

    eISSN： 1878-5883

  231. Spontaneous rupture of a renal angiomyolipoma at 25 weeks of pregnancy treated with transarterial embolization: A case report and review of the literature Peer-reviewed

    Shingo Myoen, Koji Mitsuzuka, Hideo Saito, Hideki Ota, Kei Takase, Yoichi Arai

    INTERNATIONAL JOURNAL OF UROLOGY　22　(7)　710-712　2015/07

    DOI： 10.1111/iju.12775 　

    ISSN： 0919-8172

    eISSN： 1442-2042

  232. Measurement of Peripheral Plasma 18-Oxocortisol Can Discriminate Unilateral Adenoma From Bilateral Diseases in Patients With Primary Aldosteronism Peer-reviewed

    Fumitoshi Satoh, Ryo Morimoto, Yoshikiyo Ono, Yoshitsugu Iwakura, Kei Omata, Masataka Kudo, Kei Takase, Kazumasa Seiji, Hidehiko Sasamoto, Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita, Celso E. Gomez-Sanchez, William E. Rainey, Yoichi Arai, Hironobu Sasano, Yasuhiro Nakamura, Sadayoshi Ito

    HYPERTENSION　65　(5)　1096-1102　2015/05

    DOI： 10.1161/HYPERTENSIONAHA.114.04453 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  233. Assessment of myocardial metabolic disorder associated with mediastinal radiotherapy for esophageal cancer -a pilot study- Peer-reviewed

    Rei Umezawa, Kentaro Takanami, Noriyuki Kadoya, Yujiro Nakajima, Masahide Saito, Hideki Ota, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Takaya Yamamoto, Yojiro Ishikawa, Ken Takeda, Yasuyuki Taki, Kei Takase, Keiichi Jingu

    RADIATION ONCOLOGY　10　96　2015/04

    DOI： 10.1186/s13014-015-0410-z 　

    ISSN： 1748-717X

  234. Intraventricular Hemorrhage on Initial Computed Tomography as Marker of Diffuse Axonal Injury after Traumatic Brain Injury Peer-reviewed

    Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Li Li, Kei Takase, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

    JOURNAL OF NEUROTRAUMA　32　(5)　359-365　2015/03

    DOI： 10.1089/neu.2014.3453 　

    ISSN： 0897-7151

    eISSN： 1557-9042

  235. Luminal-Type Breast Cancer: Correlation of Apparent Diffusion Coefficients with the Ki-67 Labeling Index Peer-reviewed

    Naoko Mori, Hideki Ota, Shunji Mugikura, Chiaki Takasawa, Takanori Ishida, Gou Watanabe, Hiroshi Tada, Mika Watanabe, Kei Takase, Shoki Takahashi

    RADIOLOGY　274　(1)　66-73　2015/01

    DOI： 10.1148/radiol.14140283 　

    ISSN： 0033-8419

  236. Regional Reliability of Quantitative Signal Targeting with Alternating Radiofrequency (STAR) Labeling of Arterial Regions (QUASAR) Peer-reviewed

    Yasuko Tatewaki, Shuichi Higano, Yasuyuki Taki, Benjamin Thyreau, Takaki Murata, Shunji Mugikura, Daisuke Ito, Kei Takase, Shoki Takahashi

    JOURNAL OF NEUROIMAGING　24　(6)　554-561　2014/11

    DOI： 10.1111/jon.12076 　

    ISSN： 1051-2284

    eISSN： 1552-6569

  237. Different Expression of 11 beta-Hydroxylase and Aldosterone Synthase Between Aldosterone-Producing Microadenomas and Macroadenomas Peer-reviewed

    Yoshikiyo Ono, Yasuhiro Nakamura, Takashi Maekawa, Saulo J. A. Felizola, Ryo Morimoto, Yoshitsugu Iwakura, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoichi Arai, Celso E. Gomez-Sanchez, Sadayoshi Ito, Hironobu Sasano, Fumitoshi Satoh

    HYPERTENSION　64　(2)　438-+　2014/08

    DOI： 10.1161/HYPERTENSIONAHA.113.02944 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  238. Predictors of Decreasing Glomerular Filtration Rate and Prevalence of Chronic Kidney Disease After Treatment of Primary Aldosteronism: Renal Outcome of 213 Cases Peer-reviewed

    Yoshitsugu Iwakura, Ryo Morimoto, Masataka Kudo, Yoshikiyo Ono, Kei Takase, Kazumasa Seiji, Yoichi Arai, Yasuhiro Nakamura, Hironobu Sasano, Sadayoshi Ito, Fumitoshi Satoh

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　99　(5)　1593-1598　2014/05

    DOI： 10.1210/jc.2013-2180 　

    ISSN： 0021-972X

    eISSN： 1945-7197

  239. Early CT Findings to Predict Early Death in Patients with Traumatic Brain Injury: Marshall and Rotterdam CT Scoring Systems Compared in the Major Academic Tertiary Care Hospital in Northeastern Japan Peer-reviewed

    Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Kiyoshi Ishii, Li Li, Kei Takase, Shigeki Kushimoto, Shoki Takahashi

    ACADEMIC RADIOLOGY　21　(5)　605-611　2014/05

    DOI： 10.1016/j.acra.2014.01.017 　

    ISSN： 1076-6332

    eISSN： 1878-4046

  240. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues Peer-reviewed

    Saulo J. A. Felizola, Yasuhiro Nakamura, Yoshikiyo Ono, Kanako Kitamura, Kumi Kikuchi, Yoshiaki Onodera, Kazue Ise, Kei Takase, Akira Sugawara, Namita Hattangady, William E. Rainey, Fumitoshi Satoh, Hironobu Sasano

    JOURNAL OF MOLECULAR ENDOCRINOLOGY　52　(2)　159-167　2014/04

    DOI： 10.1530/JME-13-0248 　

    ISSN： 0952-5041

  241. Characterization of lipid-rich adrenal tumors by FDG PET/CT: Are they hormone-secreting or not? Peer-reviewed

    Kentaro Takanami, Tomohiro Kaneta, Ryo Morimoto, Fumitoshi Satoh, Yasuhiro Nakamura, Kei Takase, Shoki Takahashi

    ANNALS OF NUCLEAR MEDICINE　28　(2)　145-153　2014/02

    DOI： 10.1007/s12149-013-0793-6 　

    ISSN： 0914-7187

    eISSN： 1864-6433

  242. Isoform-Specific Monoclonal Antibodies Against 3 beta-Hydroxysteroid Dehydrogenase/Isomerase Family Provide Markers for Subclassification of Human Primary Aldosteronism Peer-reviewed

    Masao Doi, Fumitoshi Satoh, Takashi Maekawa, Yasuhiro Nakamura, Jean-Michel Fustin, Motomi Tainaka, Yunhong Hotta, Yukari Takahashi, Ryo Morimoto, Kei Takase, Sadayoshi Ito, Hironobu Sasano, Hitoshi Okamura

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　99　(2)　E257-E262　2014/02

    DOI： 10.1210/jc.2013-3279 　

    ISSN： 0021-972X

    eISSN： 1945-7197

  243. Evaluation of Spinal cord ischemia with a retrievable stent graft is useful for determining the type of repair for a case of patch aneurysm Peer-reviewed

    Junetsu Akasaka, Kei Takase, Koichi Tabayashi

    Annals of Vascular Surgery　28　(5)　1313-e3　2014

    Publisher: Elsevier Inc.

    DOI： 10.1016/j.avsg.2013.08.024 　

    ISSN： 1615-5947 0890-5096

  244. Detection of invasive components in cases of breast ductal carcinoma in situ on biopsy by using apparent diffusion coefficient MR parameters Peer-reviewed

    Naoko Mori, Hideki Ota, Shunji Mugikura, Chiaki Takasawa, Junya Tominaga, Takanori Ishida, Mika Watanabe, Kei Takase, Shoki Takahashi

    European Radiology　23　(10)　2705-2712　2013/10

    DOI： 10.1007/s00330-013-2902-2 　

    ISSN： 0938-7994 1432-1084

    eISSN： 1432-1084

  245. Evaluation of radiation-induced myocardial damage using iodine-123 beta-methyl-iodophenyl pentadecanoic acid scintigraphy Peer-reviewed

    Rei Umezawa, Kei Takase, Keiichi Jingu, Kentaro Takanami, Hideki Ota, Tomohiro Kaneta, Ken Takeda, Haruo Matsushita, Hisanori Ariga, Shoki Takahashi, Shogo Yamada

    JOURNAL OF RADIATION RESEARCH　54　(5)　880-889　2013/09

    DOI： 10.1093/jrr/rrt011 　

    ISSN： 0449-3060

  246. Cardiac output obtained from test bolus injections as a factor in contrast injection rate revision of following coronary CT angiography Peer-reviewed

    Masahiko Konno, Yoshiyuki Hosokai, Akihito Usui, Mitsuya Abe, Toshiki Tateishi, Yusuke Kawasumi, Masashi Tsuda, Hideki Ota, Kei Takase, Haruo Saito

    ACTA RADIOLOGICA　53　(10)　1107-1111　2012/12

    DOI： 10.1258/ar.2012.120276 　

    ISSN： 0284-1851

  247. Properties of N-Butyl Cyanoacrylate-iodized Oil Mixtures for Arterial Embolization: In Vitro and In Vivo Experiments Peer-reviewed

    Chiaki Takasawa, Kazumasa Seiji, Kenichi Matsunaga, Toshio Matsuhashi, Makoto Ohta, Shuya Shida, Kei Takase, Shoki Takahashi

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　23　(9)　1215-1221　2012/09

    DOI： 10.1016/j.jvir.2012.06.022 　

    ISSN： 1051-0443

  248. Endovascular aneurysmal models at the external iliac artery of dogs Peer-reviewed

    Kenichi Matsunaga, Chiaki Takasawa, Kazumasa Seiji, Kei Takase, Shoki Takahashi, Toshio Matsuhashi, Yasuhiro Nakamura, Fumiyoshi Fujisihima

    JOURNAL OF VASCULAR SURGERY　55　(6)　1742-1748　2012/06

    DOI： 10.1016/j.jvs.2011.11.056 　

    ISSN： 0741-5214

  249. Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation Peer-reviewed

    Kentaro Takanami, Takayuki Yamada, Masashi Tsuda, Kei Takase, Kazuyuki Ishida, Yasuhiro Nakamura, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno, Shoki Takahashi

    ABDOMINAL IMAGING　36　(4)　447-456　2011/08

    DOI： 10.1007/s00261-010-9649-x 　

    ISSN： 0942-8925

  250. Additional value of FDG PET/CT to contrast-enhanced CT in the differentiation between benign and malignant intraductal papillary mucinous neoplasms of the pancreas with mural nodules Peer-reviewed

    Kentaro Takanami, Tomomichi Hiraide, Masashi Tsuda, Yasuhiro Nakamura, Tomohiro Kaneta, Kei Takase, Hiroshi Fukuda, Shoki Takahashi

    ANNALS OF NUCLEAR MEDICINE　25　(7)　501-510　2011/08

    DOI： 10.1007/s12149-011-0494-y 　

    ISSN： 0914-7187

    eISSN： 1864-6433

  251. 18-Oxocortisol Measurement in Adrenal Vein Sampling as a Biomarker for Subclassifying Primary Aldosteronism Peer-reviewed

    Yasuhiro Nakamura, Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Kei Takase, Celso E. Gomez-Sanchez, Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita, William E. Rainey, Hironobu Sasano, Sadayoshi Ito

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　96　(8)　E1272-E1278　2011/08

    DOI： 10.1210/jc.2010-2785 　

    ISSN： 0021-972X

  252. High-resolution magnetic resonance imaging of rotator cuff tears using a microscopy coil: noninvasive detection without intraarticular contrast material Peer-reviewed

    Shin Hitachi, Kei Takase, Minoru Tanaka, Yuichi Tojo, Shiro Tabata, Kazuhiro Majima, Shuichi Higano, Shoki Takahashi

    JAPANESE JOURNAL OF RADIOLOGY　29　(7)　466-474　2011/08

    DOI： 10.1007/s11604-011-0583-9 　

    ISSN： 1867-1071

  253. Primary aldosteronism A Japanese perspective Peer-reviewed

    Fumitoshi Satoh, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Masataka Kudo, Kei Takase, Sadayoshi Ito

    REVIEWS IN ENDOCRINE & METABOLIC DISORDERS　12　(1)　11-14　2011/03

    DOI： 10.1007/s11154-011-9161-9 　

    ISSN： 1389-9155

  254. The Fatal Risk in Hepatic Artery Embolization for Hemostasis after Pancreatic and Hepatic Surgery: Importance of Collateral Arterial Pathways Peer-reviewed

    Akihiro Sato, Takayuki Yamada, Kei Takase, Toshio Matsuhashi, Shuichi Higano, Tomohiro Kaneda, Shinichi Egawa, Kazunori Takeda, Tadashi Ishibashi, Shoki Takahashi

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　22　(3)　287-293　2011/03

    DOI： 10.1016/j.jvir.2010.11.023 　

    ISSN： 1051-0443

  255. Thoracic Duct Visualization: Combined Use of Multidetector-Row Computed Tomography and Magnetic Resonance Imaging Peer-reviewed

    Takumi Kato, Kei Takase, Hirofumi Ichikawa, Susumu Satomi, Shoki Takahashi

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　35　(2)　260-265　2011/03

    DOI： 10.1097/RCT.0b013e31820a0b0e 　

    ISSN： 0363-8715

  256. MDCT of the artery of Adamkiewicz Peer-reviewed

    Kei Takase, Shoki Takahashi

    Neurovascular Imaging: MRI and Microangiography　451-463　2011

    Publisher: Springer London

    DOI： 10.1007/978-1-84882-134-7_17 　

  257. Simultaneous Evaluation of the Whole Aorta and Artery of Adamkiewicz by MDCT. Peer-reviewed

    Takase K

    Annals of vascular diseases　4　(4)　286-292　2011

    DOI： 10.3400/avd.di.11.00725 　

    ISSN： 1881-641X

  258. Demonstration of the Anatomy of the Esophageal Artery Using Multidetector-Row Helical Computed Tomography Peer-reviewed

    Takumi Kato, Kei Takase, Hirofumi Ichikawa, Susumu Satomi, Shoki Takahashi

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　34　(6)　939-944　2010/11

    DOI： 10.1097/RCT.0b013e3181ed9cf4 　

    ISSN： 0363-8715

  259. Bronchial Artery Anatomy: Preoperative 3D Simulation with Multidetector CT Peer-reviewed

    Yoshiaki Morita, Kei Takase, Hirofumi Ichikawa, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Shoki Takahashi

    RADIOLOGY　255　(3)　934-943　2010/06

    DOI： 10.1148/radiol.10081220 　

    ISSN： 0033-8419

  260. Patient-specific morphological and blood flow analysis of pulmonary artery in the case of severe deformations of the lung due to pneumothorax Peer-reviewed

    Jean-Joseph Christophe, Takuji Ishikawa, Noriaki Matsuki, Yohsuke Imai, Kei Takase, Marc Thiriet, Takami Yamaguchi

    Journal of Biomechanical Science and Engineering　5　(5)　485-498　2010

    DOI： 10.1299/jbse.5.485 　

    ISSN： 1880-9863

  261. Treatment of in-stent restenosis with beraprost sodium: An experimental study of short- and intermediate-term effects in dogs Peer-reviewed

    Kazumasa Seiji, Masashi Tsuda, Toshio Matsuhashi, Kei Takase, Hideo Miyachi, Takayuki Yamada, Tadashi Ishibashi, Shuichi Higano, Shoki Takahashi

    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY　36　(12)　1164-1169　2009/12

    DOI： 10.1111/j.1440-1681.2009.05209.x 　

    ISSN： 0305-1870

  262. Differentiation of Femoral and Inguinal Hernias on the Basis of Anteroposterior Relationship to the Inguinal Ligament on Multidimensional Computed Tomography Peer-reviewed

    Masahiro Kitami, Kei Takase, Masahiro Tsuboi, Yuya Rikimaru, Takashi Hakamatsuka, Takayuki Yamada, Shoki Takahashi

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　33　(5)　678-681　2009/09

    DOI： 10.1097/RCT.0b013e3181977a0a 　

    ISSN： 0363-8715

  263. Tagged cine magnetic resonance imaging with a finite element model can predict the severity of retrosternal adhesions prior to redo cardiac surgery Peer-reviewed

    Ichiro Yoshioka, Yoshikatsu Saiki, Azusa Ichinose, Kei Takase, Shoki Takahashi, Toshiro Ohashi, Masaaki Sato, Koichi Tabayashi

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY　137　(4)　957-962　2009/04

    DOI： 10.1016/j.jtcvs.2008.10.036 　

    ISSN： 0022-5223

  264. Correct Diagnosis of Vascular Encasement and Longitudinal Extension of Hilar Cholangiocarcinoma by Four-Channel Multidetector-Row Computed Tomography Peer-reviewed

    Tadayuki Okumoto, Akihiro Sato, Takayuki Yamada, Kei Takase, Toshio Matsuhashi, Masashi Tsuda, Kazumasa Seiji, Tadashi Ishibashi, Shuichi Higano, Yu Katayose, Michiaki Unno, Shoki Takahashi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　217　(1)　1-8　2009/01

    DOI： 10.1620/tjem.217.1 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  265. [Use of the keyhole technique for 3.0T MRI dynamic imaging]. Peer-reviewed

    Itou D, Nagasaka T, Yanagawa I, Yoshida S, Takase K

    Nihon Hoshasen Gijutsu Gakkai zasshi　64　(12)　1562-1567　2008/12

    Publisher: Japanese Society of Radiological Technology (JSRT)

    DOI： 10.6009/jjrt.64.1562 　

    ISSN： 0369-4305

    More details Close

    We studied the feasibility of high spatial and temporally resolved imaging by a combination of keyhole imaging, which is a fast imaging method, and a 3.0T MRI system which inherently has a high signal-to-noise ratio (SNR). In keyhole imaging, full k-space reference data are collected, followed by repeated dynamic acquisition of the central low-frequency data alone, and this makes dynamic acquisition faster. The purpose of our article is to describe the effects of the reference data on the reconstructed dynamic images with the assumption of vessel visualization. For efficient use of keyhole imaging, it is important to optimize the keyhole percentage and timing of reference data acquisition for the object of interest.

  266. Differentiation of Pathologic Subtypes of Papillary Renal Cell Carcinoma on CT Peer-reviewed

    Takayuki Yamada, Mareyuki Endo, Masahiro Tsuboi, Toshio Matsuhashi, Kei Takase, Shuichi Higano, Shoki Takahashi

    AMERICAN JOURNAL OF ROENTGENOLOGY　191　(5)　1559-1563　2008/11

    DOI： 10.2214/AJR.07.3181 　

    ISSN： 0361-803X

  267. High-resolution monochrome liquid crystal display versus efficient household colour liquid crystal display: comparison of their diagnostic performance with unenhanced CT images in focal liver lesions Peer-reviewed

    Yusuke Kawasumi, Takayuki Yamada, Hideki Ota, Masahiro Tsuboi, Kei Takase, Akihiro Sato, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

    EUROPEAN RADIOLOGY　18　(10)　2148-2154　2008/10

    DOI： 10.1007/s00330-008-1008-8 　

    ISSN： 0938-7994

  268. MRI of cardiac sarcoidosis: Basal and subepicardial localization of myocardial lesions and their effect on left ventricular function Peer-reviewed

    Azusa Ichinose, Hiroki Otani, Minako Oikawa, Kei Takase, Haruo Saito, Hiroaki Shimokawa, Shoki Takahashi

    AMERICAN JOURNAL OF ROENTGENOLOGY　191　(3)　862-869　2008/09

    DOI： 10.2214/AJR.07.3089 　

    ISSN： 0361-803X

  269. Radiologic anatomy of the right adrenal vein: Preliminary experience with MDCT Peer-reviewed

    Tomonori Matsuura, Kei Takase, Hideki Ota, Takayuki Yamada, Akihiro Sato, Fumitoshi Satoh, Shoki Takahashi

    AMERICAN JOURNAL OF ROENTGENOLOGY　191　(2)　402-408　2008/08

    DOI： 10.2214/AJR.07.3338 　

    ISSN： 0361-803X

  270. Validation of the use of calibration factors between the iodine concentration and the computed tomography number measured outside the objects for estimation of iodine concentration inside the objects: phantom experiment Peer-reviewed

    Kentaro Takanami, Shuichi Higano, Kei Takase, Tomohiro Kaneta, Takayuki Yamada, Hiroki Ishiya, Issei Mori, Shoki Takahashi

    RADIATION MEDICINE　26　(4)　237-243　2008/05

    DOI： 10.1007/s11604-007-0220-9 　

    ISSN： 1862-5274

  271. Electrocardiographic characteristics of the variants of idiopathic left ventricular outflow tract ventricular tachyarrhythmias Peer-reviewed

    Koji Kumagai, Koji Fukuda, Yuji Wakayama, Yoshinao Sugai, Masanori Hirose, Nobuhiro Yamaguchi, Kei Takase, Yasuteru Yamauchi, Atsushi Takahashi, Kazutaka Aonuma, Hiroaki Shimokawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY　19　(5)　495-501　2008/05

    DOI： 10.1111/j.1540-8167.2007.01085.x 　

    ISSN： 1045-3873

  272. Validation of the use of calibration factors between the iodine concentration and the computed tomography number measured outside the objects for estimation of iodine concentration inside the objects: Phantom experiment Peer-reviewed

    Kentaro Takanami, Shuichi Higano, Kei Takase, Tomohiro Kaneta, Takayuki Yamada, Hiroki Ishiya, Issei Mori, Shoki Takahashi

    Radiation Medicine - Medical Imaging and Radiation Oncology　26　(4)　237-243　2008/05

    DOI： 10.1007/s11604-007-0220-9 　

    ISSN： 0288-2043 1862-5274

    eISSN： 1862-5274

  273. Perforated and nonperforated appendicitis: Defect in enhancing appendiceal wall - Depiction with multi-detector row CT Peer-reviewed

    Masahiro Tsuboi, Kei Takase, Iwao Kaneda, Tadashi Ishibashi, Takayuki Yamada, Masahiro Kitami, Shuichi Higano, Shoki Takahashi

    RADIOLOGY　246　(1)　142-147　2008/01

    DOI： 10.1148/radiol.2461051760 　

    ISSN： 0033-8419

  274. Virtual CT thoracoscopy: preoperative simulation for thoracoscopic surgery of esophageal cancer Peer-reviewed

    Yoshiaki Morita, Kei Takase, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Shoki Takahashi, Hirofumi Ichikawa

    ABDOMINAL IMAGING　32　(6)　679-687　2007/11

    DOI： 10.1007/s00261-006-9165-1 　

    ISSN： 0942-8925

  275. Localization of aldosterone-producing adrenocortical adenomas: significance of adrenal venous sampling. Peer-reviewed

    Satoh F, Abe T, Tanemoto M, Nakamura M, Abe M, Uruno A, Morimoto R, Sato A, Takase K, Ishidoya S, Arai Y, Suzuki T, Sasano H, Ishibashi T, Ito S

    Hypertension research : official journal of the Japanese Society of Hypertension　30　(11)　1083-1095　2007/11

    DOI： 10.1291/hypres.30.1083 　

    ISSN： 0916-9636

  276. Dilation of renal artery stenosis after administration of losartan. Peer-reviewed

    Tanemoto M, Takase K, Yamada T, Satoh A, Abe T, Ito S

    Hypertension research : official journal of the Japanese Society of Hypertension　30　(10)　999-1002　2007/10

    DOI： 10.1291/hypres.30.999 　

    ISSN： 0916-9636

  277. Primary aldosteronism: a pictorial essay Peer-reviewed

    Tadashi Ishibashi, Fumitoshi Satoh, Takayuki Yamada, Akihiro Sato, Toshio Matsuhashi, Kei Takase

    ABDOMINAL IMAGING　32　(4)　504-514　2007/08

    DOI： 10.1007/s00261-006-9151-7 　

    ISSN： 0942-8925

  278. [Cardiac CT and MRI]. Peer-reviewed

    Ichinose A, Takase K, Takahashi S, Kagaya Y, Shimokawa H

    Nihon rinsho. Japanese journal of clinical medicine　65 Suppl 4　406-411　2007/04

    ISSN： 0047-1852

  279. Peripheral Pulmonary Artery Aneurysms in Patients with Pulmonary Artery Hypertension Peer-reviewed

    Masahito Sakuma, Jun Demachi, Jun Suzuki, Jun Nawata, Tohru Takahashi, Koichiro Sugimura, Minako Oikawa, Kei Takase, Kenji Hoshino, Shinko Souma, Kunio Shirato

    INTERNAL MEDICINE　46　(13)　979-984　2007

    DOI： 10.2169/internalmedicine.46.6462 　

    ISSN： 0918-2918

  280. Preoperative MDCT evaluation of the artery of Adamkiewicz and its origin. Peer-reviewed

    Takase K, Akasaka J, Sawamura Y, Ota H, Sato A, Yamada T, Higano S, Igarashi K, Chiba Y, Takahashi S

    Journal of computer assisted tomography　30　(5)　716-722　2006/09

    DOI： 10.1097/01.rct.0000228150.35410.45 　

    ISSN： 0363-8715

  281. Comparison of MDCT and MRI for evaluating the intraductal component of breast cancer Peer-reviewed

    Akiko Shimauchi, Takayuki Yamada, Akihiro Sato, Kei Takase, Shin Usami, Takanori Ishida, Takuya Moriya, Shoki Takahashi

    AMERICAN JOURNAL OF ROENTGENOLOGY　187　(2)　322-329　2006/08

    DOI： 10.2214/AJR.05.0876 　

    ISSN： 0361-803X

  282. Diagnosis of aortic diseases using multidetector computed tomography Peer-reviewed

    Kei Takase, Hideki Ota, Hiroya Rikimaru, Akihiro Sato, Takayuki Yamada, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

    Radiation Medicine - Medical Imaging and Radiation Oncology　24　(5)　405-414　2006/06

    DOI： 10.1007/s11604-006-0046-x 　

    ISSN： 0288-2043

  283. Assessing the extent of breast cancer using multidetector row helical computed tomography Peer-reviewed

    K Takase, A Furuta, N Harada, T Takahashi, K Igarashi, Y Chiba, K Haga, S Takahashi

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　30　(3)　479-485　2006/05

    DOI： 10.1097/00004728-200605000-00021 　

    ISSN： 0363-8715

  284. Atlantoaxial osteoarthritis in rheumatoid arthritis: FDG PET/CT findings. Peer-reviewed

    Kaneta T, Hakamatsuka T, Yamada T, Takase K, Sato A, Higano S, Ito H, Fukuda H, Takahashi S, Yamada S

    Clinical nuclear medicine　31　(4)　209　2006/04

    DOI： 10.1097/01.rlu.0000204124.79497.bb 　

    ISSN： 0363-9762

  285. Evaluation of the relationship between physiological FDG uptake in the heart and age, blood glucose level, fasting period, and hospitalization Peer-reviewed

    T Kaneta, T Hakamatsuka, K Takanami, T Yamada, K Takase, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

    ANNALS OF NUCLEAR MEDICINE　20　(3)　203-208　2006/04

    DOI： 10.1007/bf03027431 　

    ISSN： 0914-7187

  286. FDG PET in solitary metastastic/secondary tumor of the kidney: A report of three cases and a review of the relevant literature

    T Kaneta, T Hakamatsuka, T Yamada, K Takasa, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

    ANNALS OF NUCLEAR MEDICINE　20　(1)　79-82　2006/01

    DOI： 10.1007/BF02985596 　

    ISSN： 0914-7187

  287. Types and frequencies of biliary tract variations associated with a major portal venous anomaly: Analysis with multi-detector row CT cholangiography Peer-reviewed

    M Kitami, K Takase, G Murakami, S Ko, M Tsuboi, H Saito, S Higano, Y Nakajima, S Takahashi

    RADIOLOGY　238　(1)　156-166　2006/01

    DOI： 10.1148/radiol.2381041783 　

    ISSN： 0033-8419

  288. FDG PET in solitary metastastic/secondary tumor of the kidney: A report of three cases and a review of the relevant literature Peer-reviewed

    T Kaneta, T Hakamatsuka, T Yamada, K Takasa, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

    ANNALS OF NUCLEAR MEDICINE　20　(1)　79-82　2006/01

    DOI： 10.1007/bf02985596 　

    ISSN： 0914-7187

  289. Time-related changes in computed tomographic appearance and pathologic findings after radiofrequency ablation of the rabbit lung: Preliminary experimental study Peer-reviewed

    J Tominaga, H Miyachi, K Takase, T Matsuhashi, T Yamada, A Sato, H Saito, T Ishibashi, M Endoh, S Higano, S Takahashi

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　16　(12)　1719-1726　2005/12

    DOI： 10.1097/01.RVI.0000182507.37324.3E 　

    ISSN： 1051-0443

  290. Quantitative vascular measurements in arterial occlusive disease Peer-reviewed

    Hideki Ota, Kei Takase, Hiroya Rikimaru, Masahiro Tsuboi, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

    Radiographics　25　(5)　1141-1158　2005/09

    DOI： 10.1148/rg.255055014 　

    ISSN： 1527-1323

  291. Quantitative vascular measurements in arterial occlusive disease. Peer-reviewed

    Ota H, Takase K, Rikimaru H, Tsuboi M, Yamada T, Sato A, Higano S, Ishibashi T, Takahashi S

    Radiographics : a review publication of the Radiological Society of North America, Inc　25　(5)　1141-1158　2005/09

    DOI： 10.1148/rg.255055014 　

    ISSN： 0271-5333

  292. Heterogeneity of subvesical ducts or the ducts of Luschka: A study using drip-infusion cholangiography-computed tomography in patients and cadaver specimens Peer-reviewed

    M Kitami, G Murakami, D Suzuki, K Takase, M Tsuboi, H Saito, S Takahashi

    WORLD JOURNAL OF SURGERY　29　(2)　217-223　2005/02

    DOI： 10.1007/s00268-004-7652-5 　

    ISSN： 0364-2313

  293. MDCT for vascular diseases; one stop shopping imaging

    Kei Takase, Y. Chiba

    Japanese Journal of Clinical Radiology　50　(1)　67-77　2005

    ISSN： 0009-9252

  294. Spiegel's lobe bile ducts often drain into the right hepatic duct or its branches: Study using drip-infusion cholangiography-computed tomography in 179 consecutive patients Peer-reviewed

    M Kitami, G Murakami, S Ko, K Takase, M Tuboi, H Saito, Y Nakajima, S Takahashi

    WORLD JOURNAL OF SURGERY　28　(10)　1001-1006　2004/10

    DOI： 10.1007/s00268-004-7483-4 　

    ISSN： 0364-2313

  295. Pseudoaneurysm of the inferior epigastric artery successfully treated by ultrasound-guided compression Peer-reviewed

    K Takase, T Kazama, K Abe, Y Chiba, H Saito, S Takahashi

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY　27　(5)　520-522　2004/09

    DOI： 10.1007/s00270-003-2767-x 　

    ISSN： 0174-1551

  296. MDCT compared with digital subtraction angiography for assessment of lower extremity arterial occlusive disease: Importance of reviewing cross-sectional images Peer-reviewed

    H Ota, K Takase, K Igarashi, Y Chiba, K Haga, H Saito, S Takahashi

    AMERICAN JOURNAL OF ROENTGENOLOGY　182　(1)　201-209　2004/01

    DOI： 10.2214/ajr.182.1.1820201 　

    ISSN： 0361-803X

  297. Another blood supply to Adamkiewicz's artery Peer-reviewed

    Junetsu Akasaka, Masahiro Sakurai, Kei Takase, Kiichiro Kumagai, Koichi Tabayashi

    Japanese Journal of Thoracic and Cardiovascular Surgery　52　(9)　432-434　2004

    Publisher: Japanese Association for Thoracic Surgery

    DOI： 10.1007/s11748-004-0039-6 　

    ISSN： 1344-4964

  298. Surgical Repair for Tracheo-Innominate Artery Fistula with a Muscle Flap Peer-reviewed

    Yoshihiro Sawamura, Kei Takase, Norio Higuchi, Sekinori Kikuchi, Takashi Ito, Koichi Tabayashi

    Japanese Journal of Thoracic and Cardiovascular Surgery　51　(11)　630-633　2003

    Publisher: Japanese Association for Thoracic Surgery

    DOI： 10.1007/BF02736707 　

    ISSN： 1344-4964

  299. 急性虫垂炎の診断と治療方針決定におけるCTの有用性

    工藤 博典, 金田 巌, 樋口 則男, 古田 昭彦, 石橋 悟, 初貝 和明, 庄子 成美, 高瀬 圭, 高橋 徹

    東北医学雑誌　114　(1)　146-146　2002/08

    Publisher: 東北医学会

    ISSN： 0040-8700

  300. マルチスライスヘリカルCTを用いた乳癌の広がり診断

    庄子 成美, 金田 巌, 樋口 則男, 古田 昭彦, 石橋 悟, 初貝 和明, 中川 有, 工藤 博典, 高瀬 圭, 高橋 徹

    東北医学雑誌　114　(1)　155-155　2002/08

    Publisher: 東北医学会

    ISSN： 0040-8700

  301. 虫垂炎診断及び手術適応決定におけるマルチスライスヘリカルCTの有用性

    工藤 博典, 金田 巖, 樋口 則男, 古田 昭彦, 石橋 悟, 初貝 和明, 庄子 成美, 高瀬 圭, 高橋 徹

    日本消化器外科学会雑誌　35　(7)　1142-1142　2002/07

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  302. Three-dimensional imaging of coronary artery bypass grafts. Peer-reviewed

    Sawamura Y, Takase K, Saito H, Kikuchi S, Ito T

    The Annals of thoracic surgery　73　(5)　1655　2002/05

    DOI： 10.1016/s0003-4975(01)02741-2 　

    ISSN： 0003-4975

  303. Demonstration of the artery of Adamkiewicz at multi-detector row helical CT Peer-reviewed

    K Takase, Y Sawamura, K Igarashi, Y Chiba, K Haba, H Saito, S Takahashi

    RADIOLOGY　223　(1)　39-45　2002/04

    DOI： 10.1148/radiol.2231010513 　

    ISSN： 0033-8419

  304. Pericardiectomy for post-coronary artery bypass grafting constrictive pericarditis; strategy for safe and complete pericardiectomy

    T. Shibuya, M. Ohmi, S. Kawamoto, M. Shimizu, M. Ohuchi, Y. Sawamura, S. Kikuchi, T. Ito, K. Takase

    Kyobu geka. The Japanese journal of thoracic surgery　55　1149-1152　2002/01/01

    ISSN： 0021-5252

  305. Three-dimensional imaging of coronary artery bypass grafts

    Yoshihiro Sawamura, Kei Takase, Haruo Saito, Sekinori Kikuchi, Takashi Ito

    Annals of Thoracic Surgery　73　(5)　1655　2002

    DOI： 10.1016/S0003-4975(01)02741-2 　

    ISSN： 0003-4975

  306. Noninvasive postoperative angiography for internal mammary artery grafts

    Y Sawamura, K Takase, H Saito, S Kikuchi, T Ito

    CIRCULATION　104　(3)　373-374　2001/07

    DOI： 10.1161/01.CIR.104.3.373 　

    ISSN： 0009-7322

  307. Obturator herniation visualized by multislice helical CT

    Kei Takase, Akihiko Furuta, Hiroyoshi Akama

    Journal of the American College of Surgeons　192　411　2001/03/24

    DOI： 10.1016/S1072-7515(00)00804-8 　

    ISSN： 1072-7515

  308. Multislice helical computed tomography for minimally invasive cardiac surgery

    Yoshihiro Sawamura, Kei Takase, Sekinori Kikuchi, Takashi Ito

    Annals of Thoracic Surgery　71　(5)　1707　2001

    DOI： 10.1016/S0003-4975(00)02013-0 　

    ISSN： 0003-4975

  309. Bronchial artery aneurysm treated with percutaneous transluminal coil embolization

    Kei Sakuma, Kei Takase, Haruo Saito, Masayuki Zuguchi, Koichi Tabayashi

    The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi　49　(5)　330-332　2001

    DOI： 10.1007/BF02913144 　

    ISSN： 1344-4964

  310. A pitfall of reusing disposable apparatus for endoscopic surgery [2] (multiple letters)

    Y. Sawamura, K. Takase, H. Saito, S. Kikuchi, T. Ito, A. S. Wechsler

    Journal of Thoracic and Cardiovascular Surgery　120　617　2000/09/18

    ISSN： 0022-5223

  311. Relationship between the pixel value in digital subtraction angiography and iodine concentration: Study in high iodine concentration with original phantom

    Koichi Chida, Sai Masahiro, Haruo Saito, Kei Takase, Masayuki Zuguchi, Masatoshi Sasaki, Tokutaro Sato

    Tohoku Journal of Experimental Medicine　190　(3)　169-176　2000

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.190.169 　

    ISSN： 0040-8727

  312. Popliteal artery entrapment syndrome: Aberrant origin of gastrocnemius muscle shown by 3D CT

    K Takase, S Imakita, S Kuribayashi, Y Onishi, M Takamiya

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　21　(4)　523-528　1997/07

    DOI： 10.1097/00004728-199707000-00003 　

    ISSN： 0363-8715

    eISSN： 1532-3145

  313. Psychiatric wandering behaviour in dementia patients correlated with increased striatal dopamine D2 receptor as shown by [11C]YM-09151-2 and positron emission tomography

    K. Meguro, M. Itoh, K. Yanai, K. Takase, S. Yamaguchi, T. Ido, A. Yamadori

    European Journal of Neurology　4　(3)　221-226　1997

    Publisher: Blackwell Publishing Ltd

    DOI： 10.1111/j.1468-1331.1997.tb00338.x 　

    ISSN： 1351-5101

  314. MR findings of avulsive cortical irregularity of the distal femur

    Tetsuro Yamazaki, Shin Maruoka, Shoki Takahashi, Haruo Saito, Kei Takase, Mamoru Nakamura, Kiyohiko Sakamoto

    Skeletal Radiology: A Journal of Radiology, Pathology and Orthopedics　24　43-46　1995/01/01

    DOI： 10.1007/BF02425946 　

    ISSN： 0364-2348

  315. Renal cell carcinoma associated with chronic renal failure: Evaluation with sonographic angiography

    Kei Takase, Shoki Takahashi, Satoru Tazawa, Yoshio Terasawa, Kiyohiko Sakamoto

    Radiology　192　(3)　787-792　1994

    Publisher: Radiological Society of North America Inc.

    DOI： 10.1148/radiology.192.3.8058948 　

    ISSN： 0033-8419

Show all ︎Show first 5

Misc. 46

  1. 右副腎皮質髄質混合腫瘍と左副腎腫瘍によるサブクリニカルクッシング症候群を合併した一例

    小林 雅幸, 小野 美澄, 宍戸 愛, 矢浦 一磨, 沼畑 貴生, 佐藤 俊宏, 黒澤 聡子, 久保 晴丸, 手塚 雄太, 尾股 慧, 山崎 有人, 高瀬 圭, 伊藤 明宏, 鈴木 貴, 片桐 秀樹

    日本内分泌学会雑誌　100　(1)　341-341　2024/05

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  2. 初診時に高レニン高アルドステロン血症を呈した片側性原発性アルドステロン症の一例

    手塚 雄太, 矢浦 一磨, 久保 晴丸, 尾股 慧, 小野 美澄, 菅原 明, 高瀬 圭, 伊藤 明宏, 山崎 有人, 鈴木 貴, 片桐 秀樹

    日本内分泌学会雑誌　99　(5)　1501-1501　2024/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  3. ロボット支援下副腎手術の衆知を集める(標準化を目指して) 原発性アルドステロン症に対するロボット支援下副腎部分切除術

    川崎 芳英, 手塚 雄太, 小野 美澄, 尾股 慧, 佐藤 友紀, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 小黒 草太, 高瀬 圭, 片桐 秀樹, 伊藤 明宏

    日本内分泌外科学会雑誌　41　(Suppl.1)　S152-S152　2024/04

    Publisher: (一社)日本内分泌外科学会

    ISSN： 2434-6535

    eISSN： 2758-8785

  4. CT画像を用いたvViTと畳込みニューラルネットワークの腎癌組織型鑑別性能の比較

    臼崎琢磨, 高木英誠, 高木英誠, 佐藤友美, 小黒草太, 高瀬圭

    泌尿器画像診断・治療技術研究会プログラム・抄録集　10th　2023

  5. Medical students’ education and radiology

    Naoko Mori, Kei Takase

    Japanese Journal of Radiology　40　(11)　1210-1211　2022/11

    DOI： 10.1007/s11604-022-01310-0 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  6. Letter to the editor on “Second‑opinion reads in prostate MRI: added value of subspecialty interpretation and review at multidisciplinary rounds”

    Naoko Mori, Shunji Mugikura, Kei Takase

    Abdominal Radiology　47　(11)　3958-3960　2022/11

    DOI： 10.1007/s00261-022-03653-8 　

    ISSN： 2366-004X

    eISSN： 2366-0058

  7. Letter to the editor on “The MRI estimations of placental thickness and cervical length correlate with postpartum hemorrhage (PPH) in patients with risk for placenta accreta spectrum (PAS) disorders”

    Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

    Placenta　128　72　2022/10

    DOI： 10.1016/j.placenta.2022.08.008 　

    ISSN： 0143-4004

    eISSN： 1532-3102

  8. Diffusion kurtosis imaging: An effective method to evaluate the grade of glioma based on the assessment of histological nuclear size and entropy

    Naoko Mori, Shunji Mugikura, Kei Takase

    Clinical Neurology and Neurosurgery　221　2022/10

    DOI： 10.1016/j.clineuro.2022.107415 　

    ISSN： 0303-8467

    eISSN： 1872-6968

  9. Risk Prediction Modeling for Thymic Tumor: Validation of MR Sequence Combination using Imputation and Machine Learning Techniques

    SHIMIZU Hiroaki, MORI Naoko, REN Hainan, MUGIKURA Shunji, TAKASE Kei

    日本医学放射線学会総会抄録集　81st　2022

    ISSN： 0048-0428

  10. American College of Rheumatology and the European League Against Rheumatism classification criteria for IgG4-related disease: an update for radiologists

    Hainan Ren, Naoko Mori, Satoko Sato, Shunji Mugikura, Atsushi Masamune, Kei Takase

    Japanese Journal of Radiology　40　(9)　876-893　2022

    DOI： 10.1007/s11604-022-01282-1 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  11. Less contrast-enhanced areas within lymph nodes in the delayed phase of contrast-enhanced MRI: a suspicious finding for lymph node metastases

    Naoko Mori, Shunji Mugikura, Kei Takase

    Clinical and Experimental Metastasis　39　(5)　713-714　2022

    DOI： 10.1007/s10585-022-10161-y 　

    ISSN： 0262-0898

    eISSN： 1573-7276

  12. 外科におけるAI利用の現状と展開 AIによる食道癌術前リンパ節診断

    高橋 梢, 大村 和元, 高浪 健太郎, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 福富 俊明, 八嶋 嘉之, 石田 孝宣, 海野 倫明, 高瀬 圭, 亀井 尚

    日本外科学会定期学術集会抄録集　121回　NES-6　2021/04

    Publisher: (一社)日本外科学会

  13. 心臓核医学による心機能解析 現在の成果と将来展望(Cardiac Functional Analysis by Nuclear Cardiology: Current Achievements and Future Prospects)

    木曽 啓祐, 樋口 慧, 大田 英揮, 安田 聡, 高瀬 圭

    日本循環器学会学術集会抄録集　85回　ME02-3　2021/03

    Publisher: (一社)日本循環器学会

  14. Texture Analysis of High-Resolution 3D T2-Weighted Images for Diagnosis of Lymph Node Metastasis of Breast Cancer

    SHIMIZU Hiroaki, MORI Naoko, MUGIKURA Shunji, OGUMA Yo, SATO Satoko, TAKASE Kei

    日本医学放射線学会総会抄録集　80th　2021

    ISSN： 0048-0428

  15. 当院でのリンパ漏・乳糜漏に対する超音波ガイド下リンパ管造影の検討

    影山 咲子, 大田 英揮, 益田 淳朗, 佐藤 友美, 森田 佳明, 高瀬 圭

    超音波医学　47　(Suppl.)　S461-S461　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  16. 非虚血心血管疾患の核医学イメージング 循環器領域のデバイス・グラフト感染診断における核医学の有用性と限界

    木曽 啓祐, 立石 恵実, 井元 晃, 寺川 裕介, 太田 靖利, 西井 達矢, 堀之内 宏樹, 樋口 慧, 村川 圭三, 福田 哲也, 高瀬 圭

    核医学　57　(Suppl.)　S101-S101　2020/10

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  17. Ultrasound-guided intranodal lymphangiography for lymphorrhea or chylorrhea

    影山咲子, 大田英揮, 益田淳朗, 佐藤友美, 森田佳明, 高瀬圭

    超音波医学 Supplement　47　2020

    ISSN： 1881-9311

  18. 重症大動脈弁狭窄症に対する経カテーテル弁置換術はBNPと左室肥大の軽減に相関して冠血流予備能を改善する

    土屋聡, 松本泰治, 大田英揮, 菊池翼, 杉澤潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 鈴木祐輔, 高橋潤, 熊谷紀一郎, 斎木佳克, 高瀬圭, 下川宏明

    日本心血管画像動態学会プログラム・抄録集　30th　2020

  19. 乳がん患者における化学療法前後のマルチモダリティを用いた心機能評価

    杉村宏一郎, 照井洋輔, 大田英揮, 多田寛, 佐藤遥, 後岡広太郎, 石田孝宣, 高瀬圭, 下川宏明

    日本性差医学・医療学会学術集会プログラム・抄録集　13th　2020

  20. A case of ultrasound-guided percutaneous transhepatic treatment for occluded choledocho-jejunostomy after living liver transplantation

    影山咲子, 大田英揮, 鎌田裕基, 高瀬圭, 宮城重人

    超音波医学 Supplement　47　2020

    ISSN： 1881-9311

  21. Exercise Training Ameliorates Vasodilator Capacity of Coronary Microvessels in Patients With Vasospastic Angina -A New Therapeutic Approach for the Coronary Functional Disorder

    Jun Sugisawa, Yasuharu Matsumoto, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Masashi Takeuchi, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Kajitani, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

    CIRCULATION　140　2019/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  22. コイル塞栓術後の再開通評価に対する造影MRIの有用性

    鎌田裕基, 佐藤友美, 大田英揮, 清治和将, 高瀬圭

    Japanese Journal of Radiology　37　(Supplement)　2019

    ISSN： 1867-1071

  23. 慢性血栓塞栓性肺高血圧症に対する4D flow MRI:肺動脈拡張術前後に於る血流動態解析

    大田英揮, 孫文羽, 佐藤遥, 杉村宏一郎, 高瀬圭

    日本心血管画像動態学会プログラム・抄録集　29th　2019

  24. 超高齢者に発症した左胃大網動脈瘤破裂の1例

    千葉和治, 水間正道, 林洋毅, 畠達夫, 伊関雅裕, 高舘達之, 川口桂, 大塚英郎, 森川孝則, 中川圭, 元井冬彦, 亀井尚, 内藤剛, 高瀬圭, 海野倫明

    日本臨床外科学会雑誌　80　2019

    ISSN： 1345-2843

  25. Focal Decrease in Cardiac 123I-Meta-Iodobenzylguanidine Uptake in Patients with Anderson-Fabry Disease

    Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Syunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

    JOURNAL OF CARDIAC FAILURE　22　(9)　S178-S178　2016/09

    ISSN： 1071-9164

    eISSN： 1532-8414

  26. Association between radiation dosimetry of the heart and the myocardial fatty acid metabolic impairment due to chemoradiation-therapy : Prospective study using I-123 BMIPP SPECT/CT

    K. Takanami, R. Umezawa, N. Kadoya, A. Arai, K. Jingu, K. Takase

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　42　S284-S285　2015/10

    ISSN： 1619-7070

    eISSN： 1619-7089

  27. Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus surgery-first for resectable pancreatic carcer (Prep-02/JSAP05).

    Michiaki Unno, Fuyuhiko Motoi, Tomoo Kosuge, Hideki Ueno, Hiroki Yamaue, Sohei Satoi, Masayuki Sho, Goro Honda, Ippei Matsumoto, Keita Wada, Junji Furuse, Tohru Furukawa, Kazuyuki Ishida, Kei Takase, Yutaka Matsuyama, Kei Nakagawa, Yu Katayose

    JOURNAL OF CLINICAL ONCOLOGY　33　(15)　2015/05

    ISSN： 0732-183X

    eISSN： 1527-7755

  28. IN PRIMARY ALDOSTERONISM WITH BILATERAL ADRENAL ADNOMAS, LAPAROSCOPIC BILATERAL ADRENAL SURGERY COULD BE AN OPTIONAL TREATMENT UNDER SELECTIVE ADRENAL VENOUS SAMPLING

    Yoshihide Kawasaki, Shigeto Ishidoya, Akihiro Ito, Yasuhiro Kaiho, Ryo Morimoto, Kei Takase, Yoichi Arai

    JOURNAL OF UROLOGY　193　(4)　E81-E81　2015/04

    ISSN： 0022-5347

    eISSN： 1527-3792

  29. Measurement of Peripheral Blood 18-Oxocortisol as the Diagnostic Method of Primary Aldosteronism and Its Subtypes

    Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Ken Matsuda, Kei Takase, Celso E. Gomez-Sanchez, William E. Rainey, Hironobu Sasano, Yoshihiro Nakamura, Sadayoshi Ito

    HYPERTENSION　62　(3)　2013/09

    ISSN： 0194-911X

    eISSN： 1524-4563

  30. Measurement of Peripheral Blood 18-Oxo-Cortisol Levels Can Discriminate Surgically Curable Primary Aldosteronism Among Hypertensive Patients, Omitting Many Steps of Diagnostic Workup

    Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Ken Matsuda, Kazumasa Seiji, Kei Takase, Hironobu Sasano, Yasuhiro Nakamura, Sadayoshi Ito

    AMERICAN JOURNAL OF HYPERTENSION　25　(12)　1318-1319　2012/12

    ISSN： 0895-7061

  31. Preliminary experience of laparoscopic simultaneous bilateral adrenalectomy for patients with aldosterone-producing adenoma

    S. Ishidoya, A. Ito, Y. Kawasaki, M. Miyazato, Y. Kaiho, F. Satoh, R. Morimoto, K. Takase, Y. Arai

    EUROPEAN UROLOGY SUPPLEMENTS　11　(1)　E1110-U309　2012/02

    ISSN： 1569-9056

  32. 胸部大動脈瘤術後患者に対するカンデサルタン投与による遠隔期の大動脈径変化の検討(パイロット・スタディより)

    鈴木佑輔, 川本俊輔, 本吉直孝, 秋山正年, 熊谷紀一郎, 安達理, 齋藤武志, 増田信也, 渋谷拓見, 佐藤真一, 齋木佳克, 高瀬圭, 大田英揮, 辻一郎, 菅原由美

    General Thoracic and Cardiovascular Surgery　59　(Supplement)　2011

    ISSN： 1863-6705

  33. Evaluation of right adrenal vein by MDCT-for accurate localization of aldosterone hypersecretion by selective adrenal venous sampling

    Kei Takase, Fumitoshi Satoh, Ryo Morimoto, Kazumasa Seiji, Masashi Tsuda, Takayuki Yamada, Sadayoshi Ito, Shoki Takahashi

    ENDOCRINE JOURNAL　57　S636-S636　2010/03

    ISSN： 0918-8959

  34. Endocrinological evaluation of successful sampling from right adrenal veins in patients with primary aldosteronism

    Ryo Morimoto, Fumitoshi Satoh, Masataka Kudo, Osamu Murakami, Yoshitsugu Iwakura, Kei Takase, Tadashi Ishibashi, Shoki Takahashi, Shigeto Ishidoya, Yoichi Arai, Yasuhiro Nakamura, Takashi Suzuki, Hironobu Sasano, Sadayoshi Ito

    ENDOCRINE JOURNAL　57　S627-S627　2010/03

    ISSN： 0918-8959

  35. Recommendation of adrenal venous sampling before surgical treatments for the patients of primary aldosteronism with adrenal nodules on CT: the differential diagnosis of 329 patients with primary aldosteronism in comparison with their computed tomographic findings

    Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshinori Iwakura, Osamu Murakami, Kei Takase, Shoki Takahashi, Yoichi Arai, Yoshihiro Nakamura, Takashi Suzuki, Hironobu Sasano, Sadayoshi Ito

    ENDOCRINE JOURNAL　57　S552-S552　2010/03

    ISSN： 0918-8959

  36. Renal outcome in patients with primary aldosteronism: manifestation of "masked" CKD by correction of aldosterone-induced glomerular hyperfiltration and one-year follow-up with aldosterone blockade or unilateral adrenalectomy

    Yoshitsugu Iwakura, Ryo Morimoto, Masataka Kudo, Osamu Murakami, Kei Takase, Shigeto Ishidoya, Yoichi Arai, Hironobu Sasano, Hiroshi Sato, Fumitoshi Satoh, Sadayoshi Ito

    ENDOCRINE JOURNAL　57　S647-S647　2010/03

    ISSN： 0918-8959

  37. ECG-gated MDCT of the patent ductus arteriosus in adult cases. Imaging findings and impact on management

    K. Takase, S. Matsumoto, S. Yoshida, Y. Morita, H. Saito, S. Takahashi

    EUROPEAN HEART JOURNAL　30　490-490　2009/09

    ISSN： 0195-668X

  38. Evaluation of cardiac dyssynchrony in patients with chronic heart failure using cardiacmagnetic resonance imaging

    Yuji Wakayama, Koji Fukida, Masanori Hirose, Nobuhiro Yamaguchi, Minako Oikawa, Azusa Ichinose, Kei Takase, Yutaka Kagaya, Hiroaki Shimokawa

    JOURNAL OF CARDIAC FAILURE　14　(7)　S164-S164　2008/09

    ISSN： 1071-9164

  39. PE-319 Usefulness of Three-Dimensional Analysis with Multi-Detector Row Computed Tomography in the Treatment of Atrial Fibrillation(CT/DSA-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Ichinose Azusa, Kumagai Koji, Takase Kei, Morita Yoshiaki, Kagaya Yutaka, Takahashi Shoki, Shimokawa Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society　71　404-404　2007/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  40. 【血管炎 その臨床所見と画像診断】 大動脈疾患

    大田 英揮, 高瀬 圭, 高橋 昭喜

    臨床画像　21　(8)　840-848　2005/08

    Publisher: (株)メジカルビュー社

    ISSN： 0911-1069

  41. Fogarty法およびバルーン血管形成・ステント留置を併用して治療し得た広範囲腸骨大腿動脈閉塞の1例

    力丸 裕哉, 後藤 均, 初貝 和明, 石井 正, 金田 巌, 高瀬 圭

    日独医報　49　(4)　747-747　2005/02

    Publisher: バイエル薬品(株)

    ISSN： 0912-0351

  42. 【MDCT利用による診断】 大血管,末梢血管領域におけるMultidetector CTの有用性

    大田 英揮, 高瀬 圭, 高橋 昭喜

    断層映像研究会雑誌　31　(1)　10-14　2004/03

    Publisher: 断層映像研究会

    ISSN： 0914-8663

  43. CTで診断しえた閉鎖孔ヘルニアの3例

    横山 元昭, 金田 巌, 古田 昭彦, 石井 正, 石橋 悟, 初貝 和明, 後藤 均, 檜 顕成, 工藤 博典, 高瀬 圭, 力丸 裕也

    東北医学雑誌　115　(2)　186-187　2003/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  44. Assessing the extent of breast cancer by multislice helical CT

    K Takase, A Furuta, N Shouji, T Takahashi, K Haga, K Igarashi

    RADIOLOGY　225　117-117　2002/11

    ISSN： 0033-8419

  45. Evaluation of the artery of Adamkiewicz by multislice helical CT

    K Takase, Y Sawamura, K Igarashi, Y Chiba, K Haga

    RADIOLOGY　217　136-136　2000/11

    ISSN： 0033-8419

  46. A pitfall of reusing disposable apparatus for endoscopic surgery

    Y Sawamura, K Takase, H Saito, S Kikuchi, T Ito

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY　120　(3)　617-617　2000/09

    ISSN： 0022-5223

Show all ︎Show first 5

Books and Other Publications 21

  1. 月刊新医療2025年4月号(第52巻第4号) 巻頭言 第84回日本医学放射線学会総会 開催にあたって─Radiology for Everyone 高瀬 圭［第84 回日本医学放射線学会総会 会長］

    高瀬 圭

    株式会社エム・イー振興協会　2025/04/01

    More details Close

    刊行日2025/3/21 ISSN0910--7991

  2. 副腎腫瘍取扱い規約 第４版

    (作成委員会)日本泌尿器科学会・日本病理学会・日本医学放射線学会・日本内分泌学会・日本内分泌外科学会

    メディカルレビュー社　2025/03/31

    ISBN: 9784779228124

  3. 画像診断 2025年1月号 Vol.45 No.1 ビギナーのための胸部画像診断 ―Q&A アプローチ― 2025 すとらびすむす

    株式会社Gakkenメディカル出版事業部　2024/12/25

    ISBN: 405520115X

  4. 原発性アルドステロン症診療マニュアル 改訂第4版

    編集顧問, 平田 結喜緒, 編集, 成瀬光栄, 田辺晶代, 方波見卓行

    診断と治療社　2024/06/20

    ISBN: 9784787826626

  5. 保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

    高瀬 圭, 小黒 草太, 尾股 慧, 小野 美澄, 手塚 雄太, 森本 玲, 佐藤 文俊, 大田 英揮

    日本内分泌学会雑誌 99(1)　2023/05

  6. 経静脈的アブレーションによる原発性アルドステロン症の治療;First-in-Human

    高瀬 圭, 小黒 草太, 尾股 慧, 小野 美澄, 手塚 雄太, 森本 玲, 佐藤 文俊, 榊原 宏幸, 大田 英揮

    日本内分泌学会雑誌 99(1)　2023/05

  7. 画像診断2022年12月号 Vol.42 No.14 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第6回(全6回)最終回 薬事承認後から保険収載まで その2

    株式会社Gakkenメディカル出版事業部　2022/11/25

    ISBN: 4780905591

  8. 画像診断2022年11月号 Vol.42 No.13 新連載 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第5回(全6回) 薬事承認から保険収載に向けて

    株式会社学研メディカル秀潤社　2022/10/25

    ISBN: 4780905583

  9. 臨床画像2022年10月号 Vol.38 No.10 特別連載 沸騰放射線 原発性アルドステロン症のラジオ波焼灼治療 疾患の基本, 医師主導治験から保険収載まで [第3回] 治験結果から申請, 承認まで

    高瀬 圭

    株式会社メジカルビュー社　2022/09/26

  10. 画像診断2022年10月号 Vol.42 No.12 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第4回(全6回)医療機器開発の3つの障壁

    高瀬 圭

    株式会社学研メディカル秀潤社　2022/09/25

    ISBN: 4780905575

  11. 画像診断2022年9月号 Vol.42 No.10 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第3回(全6回)医療機器開発の自験例と課題

    高瀬 圭

    株式会社学研メディカル秀潤社　2022/08/25

    ISBN: 4780905567

  12. 【アルドステロンをめぐる臨床課題】原発性アルドステロン症治療におけるラジオ波治療の意義

    柳垣 聡, 小黒 草太, 清治 和将, 高瀬 圭, 尾股 慧, 手塚 雄太, 小野 美澄, 森本 玲, 田中 哲洋, 佐藤 文俊

    糖尿病・内分泌代謝科 55(2)　2022/08

  13. 臨床画像2022年8月号 Vol.38 No.8 特別連載 沸騰放射線 原発性アルドステロン症のラジオ波焼灼治療 疾患の基本, 医師主導治験から保険収載まで [第2回] 開発から医師主導治験までの経緯

    高瀬 圭

    株式会社メジカルビュー社　2022/07/26

  14. 画像診断2022年8月号 Vol.42 No.9 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第2回(全6回)Schopenhauerの言葉に学ぶ医療機器開発の3段階

    高瀬 圭

    株式会社学研メディカル秀潤社　2022/07/25

    ISBN: 4780905559

  15. 画像診断2022年7月号 Vol.42 No.8 新連載 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第1回(全6回) Shopenhauer(ショーペンハウアー)の思想と医療機器開発の目的

    高瀬 圭

    株式会社学研メディカル秀潤社　2022/06/25

    ISBN: 4780905540

  16. 臨床画像 2022年6月号 Vol.38 No.6 特別掲載 沸騰放射線：原発性アルドステロン症のラジオ波焼灼治療 疾患の基本，医師主導治験から保険収載まで［第1回］疾患概念と治療の実際

    高瀬 圭

    株式会社メジカルビュー社　2022/05/26

  17. これから始めるIVR

    小黒草太, 鎌田裕基, 高瀬圭

    株式会社メジカルビュー社　2022/03/30

    ISBN: 4758321116

  18. IVRのすべて

    小黒草太, 鎌田裕基, 高瀬圭

    メジカルビュー社　2021/03/28

  19. 人体のメカニズムから学ぶ画像診断技術学

    高瀬圭, 佐藤友美

    メジカルビュー社　2020/03/10

    More details Close

    -執筆部分- 1章 画像解剖学の基礎 6 泌尿器・生殖器 P. 60-66 4章 腹部（消化器、泌尿器、生殖器）の画像診断技術 7 腎・尿路疾患の病態と画像 P. 372-385 8 生殖器疾患の病態と画像 P.386-403 9 その他の病変の病態と画像 P. 404-407

  20. 原発性アルドステロン症診療マニュアル

    高瀬 圭

    診断と治療社　2007/11

    ISBN: 9784787815804

  21. 3次元医用画像作成秘法マニュアル - Zio M900の基礎から臨床での活用法まで

    高瀬 圭

    メジカルビュー社　2004/10

Show all Show first 5

Industrial Property Rights 8

  1. 原発性アルドステロン症の検出方法及びモノクローナル抗体

    岡村 均, 土居 雅夫, 佐藤 文俊, 笹野 公伸, 森本 玲, 伊藤 貞嘉, 中村 保宏, 高瀬 圭

    特許第6345596号

    Property Type: Patent

  2. 高周波治療用カテーテル

    高瀬 圭, 清治 和将, 日本ライフライン株式会社 森 謙二, 光宗 倫彦

    Property Type: Patent

  3. 診断画像システム

    高瀬 圭、株式会社島津製作所 加治木 駿介、能登原 大介

    Property Type: Patent

  4. 診断画像システムおよび診断用情報処理装置

    高瀬 圭、株式会社島津製作所 加治木 駿介、能登原 大介

    Property Type: Patent

  5. バルーンカテーテル、副腎腫瘍のケミカルアブレーション治療装置および副腎静脈採血装置

    高瀬 圭, 清治 和将, 日本ライフライン株式会社 森 謙二, 光宗 倫彦

    Property Type: Patent

  6. 振動針装置及び針の挿入方法

    菊地謙次, 杉山航二郎, 石川拓司, 高瀬圭

    Property Type: Patent

  7. 診断画像システム、レポート⽣成装置およびレポート⽣成⽅法

    高瀬 圭、株式会社島津製作所 加治木 駿介、能登原 大介

    Property Type: Patent

  8. 診断画像システム

    高瀬 圭、株式会社島津製作所 加治木 駿介、能登原 大介

    Property Type: Patent

Show all Show first 5

Research Projects 29

  1. Elucidation of the pathophysiology of Alzheimer's disease by a novel tau-specific PET tracer, [F18]SNFT-1

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  2. Pathophysiology of Alzheimer's disease using a novel tau-specific PET tracer, [F18]SNFT-1

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  3. 慢性関節炎の微小血管塞栓術に関する基礎実験

    小黒 草太, 高瀬 圭, 石幡 浩志, 権田 幸祐, 太田 信, 中村 保宏, 大田 英揮, 佐藤 友美, 鎌田 裕基

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  4. Quantitative MAO-B imaging of human brain and whole-body organs using [18F]SMBT-1 PET

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2025/03/31

  5. Quantitative brain and whole-body MAO-B imaging with [18F]SMBT-1 and PET

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2025/03/31

  6. Balloon expandable radiofrequency ablation catheter to treat primary aldosteronism

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2020/04/01 - 2023/03/31

  7. 蚊の口針と吸血機構を応用した副腎静脈サンプリングおける超選択的採血システムの開発

    清治 和将, 高瀬 圭, 森本 玲, 小野 美澄

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

  8. Development of imaging diagnosis support system for emergency patients by artificial intelligence

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2019/04/01 - 2023/03/31

  9. Early diagnosis of atherosclerosis by accurate ultrasonic measurement of surface roughness of internal elastic membrane

    Kanai Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Institution: Tohoku University

    2019/10/07 - 2022/03/31

    More details Close

    We have developed a method to exclude unnatural shapes at both ends of the surface shape measured for each beam by limiting the analysis range to the monotonically increasing part of the lateral displacement when measuring the surface shape for each beam. Furthermore, by interpolating the surface shape measured for each beam for each 1-micron lateral position, the error power is calculated with equal weight at all lateral positions of the surface shape measured for each beam, and the height is adjusted appropriately. We also developed a method. As a result, it became possible to obtain carotid artery surface roughness in vivo by reducing the beam-to-beam variation after adjusting the height of the surface shape measured for every single beam. These results were obtained by referring to Professor Wilhjelm's many years of research.

  10. Ultrasonic visualization of propagation of electrical excitation causing contraction by measuring human myocardial response

    Kanai Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2019/06/28 - 2022/03/31

    More details Close

    In the early stage of ischemic heart disease, the ischemic region can avoid myocardial necrosis by rapidly reperfusing the coronary arteries. Therefore, rapid identification of the ischemic region is important, and local and highly accurate velocity estimation is the key to the evaluation of local myocardial contraction characteristics using ultrasound. In this study, we analyzed the received ultrasonic signal at multiple frequencies and proposed a speed estimation method using ultrasonic phase differences at multiple different frequencies. This proposed method can reduce the effects of attenuation and interference as described above without performing spatial averaging, and local velocity estimation is possible. The proposed method can estimate the velocity with a shorter window width than the conventional method, and can measure the local velocity distribution and the local myocardial strain rate.

  11. MRIアーティファクトフリーとX線視認性を両立させた新規医療用形状記憶合金の創製

    金高 弘恭, 細田 秀樹, 高瀬 圭, 沼野 智一, 古谷 真衣子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(B)

    Category: 基盤研究(B)

    Institution: 東北大学

    2019/04/01 - 2022/03/31

    More details Close

    近年、形状記憶効果と超弾性特性を併せ持つ形状記憶合金が着目されるようになった。しかしながら、現在、唯一実用化されているNiTi合金は、生体安全性への懸念、MRI撮影やX線CT撮影時の金属アーティファクト、さらに、血管X線撮影では低い視認性など、臨床的な問題が指摘されている。そこで本研究では、人体と同じ体積磁化率を有し、かつ重元素で構成される形状記憶合金としてAuCuAl合金を作製する。材料特性および生体適合性についての評価結果を材料作製段階までフィードバックしながらMRIアーティファクトフリーとX線視認性を両立させた合金を開発し、その生物学的安全性と臨床的有効性を検証する。 本研究では、最新の材料学技術に基づく合金設計および組成制御により、MRIアーティファクトフリーとX線視認性を両立させた新規医療用形状記憶合金を創製することを目的とした。具体的には、人体と同じ体積磁化率を有し、かつ重元素で構成される形状記憶合金としてAuCuAl合金を作製する。材料特性および生体適合性についての評価結果を材料作製段階までフィードバックしながらMRIアーティファクトフリーとX線視認性を両立させた合金を開発し、その生物学的安全性と臨床的有効性を検証した。 本年度の研究成果として、開発したAuCuAl合金に対する性能評価を行った。具体的には、①形状可変機能（形状記憶・超弾性）および機械的特性評価、②MRIアーティファクト評価、③X線視認性評価、④生体適合性評価により開発合金の性能評価を行った。

  12. Development of diagnostic method for breast cancer axillary lymph node micrometastasis by three-dimensional ultrahigh-frequency contrast ultrasound

    TAKASAWA CHIAKI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

    More details Close

    Breast axillary lymph node metastasis is divided into coarse metastasis with a lesion size of 2 mm or more and micrometastasis with a size of less than 2 mm. Since the treatment methods differ between the two, it is important to determine whether the metastasis is micrometastasis or gross metastasis in order to select an appropriate treatment and maintain the patient's QOL. We (1) compare one-to-one correspondence images with intraoperative contrast-enhanced ultrasound and pathological findings, (2) develop three-dimensional ultrahigh-frequency contrast-enhanced ultrasound imaging and perfusion defect detection methods for lymph nodes, and (3) preoperative three-dimensional ultra-high-frequency contrast-enhanced. We confirmed the ability to detect lymph node micrometastasis by ultrasound, and established a method for detecting lymph node micrometastasis by contrast-enhanced ultrasound.

  13. Development of MRI diffusion-weighted imaging technology for rapid intraoperative stump diagnosis of breast cancer

    Mori Naoko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

    More details Close

    Using the latest clinical MRI system, MRI imaging including diffusion-weighted imaging was performed preoperatively, and the images and pathology were compared in about 46 cases. The visual signal and diffusion coefficient of the sample diffusion-weighted images of the lesions of normal mammary gland, ductal carcinoma in situ and invasive cancer were obtained, and it was verified whether the tumor part could be correctly discriminated compared with the normal mammary gland. The diffusion coefficient was higher in the order of invasive cancer, non-invasive cancer, and normal mammary gland. The area ratio of the pathological interstitium was significantly correlated with the diffusion coefficient, but the area ratio of cytoplasm and nucleus did not correlate with the diffusion coefficient. The number of cells and nuclei did not correlate with the diffusion coefficient.

  14. Fluid mechanical basic research for the treatment of dissecting aortic aneurysms with multi-layered blood flow control stents

    YUSUKE SUZUKI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

    More details Close

    A dissected blood vessel model was created. We designed a pulsatile flow circulation circuit incorporating a pseudo-dissected blood vessel model. Hemodynamic analysis was performed before and after placing the MFM stent in the true lumen. As a result, a pulsating water flow was observed in the false lumen before the MFM stent was placed, and an accelerated water flow was observed in the entry part. On the other hand, after the MFM stent was placed, the laminar flow was almost laminar, and no accelerated water flow was observed. From the above, it was considered that the water flow into the false lumen remains, but the water flow flowing into the false lumen through this MFM stent is rectified, the turbulence is reduced, and the shear stress applied to the false lumen wall is reduced. These results indicate that the MFM stent may be useful as a treatment for dissecting aortic aortic aneurysm.

  15. Radiation cognitive impairment: Elucidation of onset mechanism by Advanced MR and verification by animal model

    Mugikura Shunji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/04/01 - 2021/03/31

    More details Close

    In this study, we will elucidate the onset mechanism of radiation cognitive impairment using Advanced MRI in long-term survivors of childhood cancer and verify it in post-irradiation cognitive impairment mice. In childhood cancer long-term survivors, microstructural changes and brain activity changes were quantified using Advanced MR including T2 star. In addition, the same subject was subjected to an adult function test and a function test, which are cognitive function tests, and the test results were quantified and analyzed. At the same time, a QOL evaluation was performed on the same subject using a questionnaire. In addition to the above cognitive function test and QOL evaluation, data including basic patient information was organized.

  16. A study on noninvasive ultrasonic measurement of visco-elastic property between blood pressure and strain

    KANAI Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

    More details Close

    To establish an evaluation index for vascular endothelial function, we developed an ultrasonic probe that can measure changes in blood pressure and blood vessel diameter at the same position in the radial artery. Based on phantom experiments, the pressure waveforms measured using the piezoelectric effect of the ultrasonic probe element and those using a pressure sensor exhibited a high correlation. We confirmed the continuous measurement of the relationship between changes in blood pressure and diameter to estimate the changes in viscoelasticity by calibrating the output from the probe element to the absolute blood pressure values in advance. We measured the changes in the viscoelastic moduli of several subjects at rest and examined the accuracy of the estimated values. This study demonstrated the possibility of measuring changes in the viscoelastic moduli of the radial arterial wall due to flow-mediated dilation using the developed ultrasonic probe.

  17. Transvenous radiofrequency ablation system for the treatment of primary aldosteronism.

    Kei Takase

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

    More details Close

    We initially developed flexible type metallic ablation catheter with coop-tip system which can be inserted via a guiding sheath using over-the-wire technique. We evaluated electrical and mechanical safety, reachability to left adrenal vein via femoral vein, and ablative volume to make improvement of the system. The ablation performance was evaluated by gel-model study and ex-vivo ablation of bovine adrenal gland to establish dosimetry table. Ablation volume under blood perfusion to adrenal gland will be evaluated by in-vivo ablation of porcine adrenal grand, in which protocol of blood pressure stabilization during the ablation should also be established. Reachability of the system to human adrenal gland was also evaluated by using a real-size vascular model based on 3D-CT data. After development of this system, most of the primary aldosteronism patients will be treated low-invasively leading to reduction of severe cardiovascular complications and medical cost.

  18. Development of minimally invasive treatment of primary aldosteronism using adrenal vein sampling technique

    SEIJI KAZUMASA

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2020/03/31

    More details Close

    We developed a micro-balloon catheter that can be inserted and placed in the adrenal vein and can be occluded the adrenal vein. First, the operation performance of the micro-balloon catheter was evaluated using a 3D blood vessel model, and then the adrenal vein closure performance by balloon and the necrosis range of the adrenal tissue by intravenous infusion of absolute ethanol were measured using porcine adrenal glands, and the effects on surrounding tissues were evaluated. Most of the adrenal tissue was found to have coagulated necrosis with congestion and bleeding. Little damage was observed in the peri-adrenal tissues. Evaluation of small-sized microcatheter designed to obstruct the adrenal tributary vein using porcine adrenal glands revealed damage to the small-diameter vein due to balloon dilatation and absolute ethanol leakage from the damaged site. Therefore, we were unable to stably necrotic adrenal tissue.

  19. Primary aldosteronism: Establishment of tissue-sparing adrenalectomy according to the results of segmental adrenal venous sampling

    ISHIDOYA SHIGETO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

    More details Close

    We evaluated whether laparoscopic adrenalectomy (ADX) would improve general health-related quality of life (HRQOL) and nocturia for patients with primary aldosteronism (PA). A total of 173 patients were asked to fill out the HRQOL questionnaires RAND 36-Item Health Survey (SF-36) and International Prostate Symptom Score (I-PSS) preoperatively. Patients were associated with significantly low score of General Health domain compared with normal Japanese population. Among 4 physical domains, General Health scored significantly higher throughout the post-operative period. Among 4 mental domains, scores of Vitality, Social Function, and Mental Health significantly increased after ADX. Patients with PA were suffered from average 2.6 times of urination per night, which significantly decreased after ADX. ADX for PA patients generally improved HRQOL for 2 years. Patients with PA were associated with nocturia which was significantly recovered by ADX.

  20. Installation and utilization situation of MRI in Japan

    Sato Miho, TAKASE Kei, INABA Yohei, MORI Naoko, NAGASAKA Tatsuo, HIKICHI Takeo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

    More details Close

    Even though it is frequently cited that Japan has the highest number of MRIs per person, we rarely find studies evaluated those utilities and installations. This study aims to survey MRI installation and utilities in Japan. We mailed questionnaire to 5,437 facilities have MRI(s) and we received 2,272 responses (41.8% response rate). Questions include the type of facility, the detail information about their installed MRI, and their utilization such as operation rate per day, target of scans, scan protocol, staffing, etc. From a statistical analysis of the collected data, many of the clinics and the hospitals with a small number of beds did not have a full-time radiologist or a radiographer. This data will be effective for future discussion of MRI installation in Japan.

  21. Recommended protocol for breast diffusion weighted images and standardization of ADC values

    Maekawa Yui

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

    More details Close

    Although the correlation with the prognostic factor of breast cancer is known as the improvement of the specificity in the discrimination between benign and malignant as the usefulness of diffusion weighted images in breast cancer, it is stated that the sequence is expected at the research level in the future Only. In the background, DWI believes that standardization is difficult, distortion in the breast region by EPI method, noise, magnetic susceptibility artifacts. In this research, DWI imaging of the TSE method was taken as a new method against the conventional EPI method, and the image quality and the diagnostic ability were compared. As a result, the TSE method is superior to the EPI method in terms of improving SNR and distortion, and imaging of DWI using the TSE method is considered to be an imaging method leading to standardization.

  22. Development of early diagnosis and treatment for lymph node metastasis

    Kodama Tetsuya

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

    More details Close

    There are few pre-clinical studies of early diagnosis and treatment for lymph node (LNM). The reasons mainly are due to the lack of a noninvasive imaging system capable of monitoring metastasis over time in an appropriate animal model. We developed MXH10/Mo/lpr mice, which develop systemic swelling of LNs up to 10 mm in diameter. Here we show using MXH10/Mo/lpr mice that we developed an ultrasound/micro-CT system which consists of a high-frequency ultrasound system and a micro-CT system, and a lymphatic drug delivery system (LDDS) using acoustic liposomes (ALs) and ultrasound (US). Vascular distribution in the metastatic LNs can qualitatively expressed by the ultrasound/micro-CT system at the early stage of LNM. While, the LDDS using US and ALs delivered doxorubicin into metastatic LNs, resulting in an effective treatment for early metastatic LNs. We anticipate that our methodology could be applied clinically for early metastatic LNs.

  23. A Study on Ultrasound Accurate Measurement of Luminal Surface Roughness of Human Carotid Artery for Early Diagnosis of Atherosclerosis

    Kanai Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

    More details Close

    The diagnosis of atherosclerosis in the early stage is crucial for preventing degeneration of arteries. In the early stage of atherosclerosis, the arterial wall becomes rough due to endothelial cell proliferation and degeneration of the internal elastic layer. For the early diagnosis of atherosclerosis, our group has proposed a method to estimate the micron-order luminal surface roughness of the carotid artery. In the present study, a technique was developed that suppresses error in estimating surface roughness caused by the movement of a carotid artery during one cardiac cycle. The average surface roughness of the carotid artery estimated by the proposed method was 2.33 μm in three young subjects (from 20 to 30 years old) and 3.36 μm in three older subjects (from 50 to 65 years old). These results show the high potential of the proposed method for accurate estimation of the minute surface roughness of the carotid artery.

  24. Quantification of breast cancer microenvironment by three dimensional integration of micro bubble contrast ultrasound and MRI image

    Takasawa Chiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

    More details Close

    The quantitative method of contrast ultrasound is currently equipped with time intensity curve analysis in clinical models. Peak intensity and area under the curve are calculated as parameters, and it is reported that these correlate with MVD. As a new method, we focus on a certain pixel, measure how the color of pixel changes in the time axis direction, divide one with a large degree of change and one with a small change by threshold．We developed a method to detect things as detected pixels of the contrast agent. Finally, an area ratio (enhancement area ratio) of the region where the contrast medium is detected is calculated with respect to the region of interest. In this study, we clarified that the enhancement area ratio correlates with the pathological MVD of invasive cancer.

  25. Primary aldosteronism: Assessment of tissue-sparing adrenalectomy according to the results of segmental adrenal venous sampling

    ISHIDOYA SHIGETO, KAWASAKI YOSHIHIDE, TAKASE KEI, KAIHO YASUHIRO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

    More details Close

    We investigated whether tissue-sparing laparoscopic bilateral adrenal surgery was applicable or not for patients with bilateral primary aldosteronism (PA). Endocrinological examination was conducted for patients with hypertension and PA patients were selected. Segmental adrenal venous sampling (sAVS) was performed for PA patients. Then bilateral intara-adrenal venous map has become apparent which enabled us to recognize the aldosterone-hypersecreting regions. Urologists performed laparoscopic bilateral adrenal surgery with partial conservation (LBASpc) for selected 42 patients with bilateral PA disease. All patients were normalized plasma aldosterone concentration (PAC) and 98 % achieved reduction of antihypertensive medication after LBASpc. Moreover, 72% of patients has become free from corticoid replacement therapy (CRT) after surgery. Preoperative PAC was the risk factor for persistent CRT. The study indicated that LBASpc could be applicable for selected patients with bilateral PA.

  26. Development of a new catheter for segmental adrenal venous sampling

    Seiji Kazumasa, Takase Kei, Morimoto Rei, Oota Makoto, Haga Yoichi, Nakamura Yasuhiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

    More details Close

    Segmental venous sampling is essential for diagnosis and localization of aldosterone producing adenomas. In segmental adrenal venous sampling (S-AVS), blood samples are obtained with microcatheters inserted into the target venous tributary. However, it sometimes happen that blood samples cannot be obtained through catheters. In such cases, it is assumed that suction pressure deforms venous wall, then catheter tip is considered to be occluded. To our knowledge, there has been no study concerning hemodynamics in venous catheter blood sampling. The purpose of this study is to simulate the blood flow in venous blood sampling using synthetic very small blood vessel or Computational Fluid Dynamics method and to search the catheter tip shape suitable for the procedure. The prototype of microcatheter whose tip was shaped suitable for S-AVS was created. And then, the performance of the microcatheter was evaluated in an animal study.

  27. Cost-Effectiveness Analysis of the Hypertension Treatment; pursuing cost reduction of national health expenditure

    SATO MIHO, KAKIHARA Hiroaki, TAKASE Kei, SEIJI Kazumasa, MORIMOTO Ryo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

    More details Close

    Approximately 10% of cases of hypertension in Japan are caused by primary aldosteronism (PA), amounting to about 4 million patients in total. Primary aldosteronism due to unilateral aldosterone hypersecretion is potentially curable by adrenalectomy. The clinical benefits of identifying and treating PA have been reported internationally, but its cost-effectiveness is unclear. We examined whether diagnosing and treating hidden PA in hypertensive population was cost-effective compared with suboptimal treatment. We established a Markov decision model based on plausible clinical pathways and prognoses of PA. The result was cost-effective, but our findings were sensitive to the outcomes of screening and treatment, and the costs of continuous or periodic medication for hypertension and the treatment of stroke and its complications.

  28. Development of minimally-invasive interventional radiological therapy of primary aldosteronism based on adrenal venous sampling.

    TAKASE KEI, OOTA Makoto, MORIMOTO Ryou, SEIJI Kazumasa, SATOU Fumitoshi, SATOU Miho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2011/04/01 - 2014/03/31

    More details Close

    Real-size vascular model including adrenal venous tributaries was generated, which was utilized for simulation of catheterization. Experimental study using bovine adrenal gland showed that 3 insertion patterns of bipolar needles enables complete ablation of adrenal adenoma with 10 to 25-mm in diameter. Adjacent organ with 5-mm intervening adipose tissue was preserved. Initial clinical interventional radiological treatment achieved normalization of plasma aldosterone level and amount in 24-hour urine specimen. Cost-effectiveness of this treatment was also proven.

  29. Preoperative evaluation of the artery of Adamkiewicz of Japa ese and European patients using MDCT and MRI

    TAKASE Kei

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2007 - 2010

    More details Close

    Accurate localization of the artery of Adamkiewicz (AKA)is important in planning treatment of patients with thoracoabdominal aortic disease. We assessed the usefulness of three-dimensional imaging devices such as multi-detector-row helical computed tomography (MDCT)and 3 Tesla (T)MRI in the preoperative evaluation of the artery of Adamkiewicz (AKA)and its parent artery. 3T-MRA was also performed in patients whose AKA was difficult to visualize because of artifact from bony structures.

Show all Show first 5

Media Coverage 51

  1. 第84回日本医学放射線学会総会の開催にあたって

    病院新聞社　病院新聞第2840号　1

    2025/04/10

    Type: Newspaper, magazine

  2. 放射線医療現場市民講座で体験

    河北新報社　河北新報　みやぎワイド（14）

    2024/11/17

    Type: Newspaper, magazine

  3. 第84回日本医学放射線学会「レントゲンの日記念」市民公開講座が開催 ——「来て見て触ってみよう！放射線医療」をテーマに，中高生らが体験会に参加

    株式会社インナービジョン　インナビネット　取材報告 >新製品発表・学会などの通常取材

    2024/11/01

    Type: Internet

  4. 放射線診断を分かりやすく説明 10月27日 仙台・アエルで市民講座

    河北新報社　河北新報　6右下 経済&暮らし情報 河北Bizナビ ピックアップ

    2024/10/10

    Type: Newspaper, magazine

  5. 放射線診断を分かりやすく説明 10月27日 仙台・アエルで市民講座

    河北新報社　河北 Biz ナビ　ピックアップ

    2024/10/10

    Type: Promotional material

  6. 第84回 日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』開催のお知らせ（10/27開催）

    東北大学病院　新着情報>イベント

    2024/09/30

    Type: Other

  7. 第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』開催のお知らせ（10/27開催）

    東北大学大学院医学系研究科・医学部　イベント

    2024/09/30

    Type: Other

  8. 第84回日本医学放射線学会「レントゲンの日記念」市民公開講座 「来て見て触ってみよう！放射線医療」

    河北新報社　こども新聞 週刊かほピョンプレス　8下段

    2024/09/29

    Type: Promotional material

  9. 第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』（10/27開催）

    東北大学　2024年のイベント

    2024/09/20

    Type: Other

  10. 第84回日本医学放射線学会「レントゲンの日記念」市民公開講座 「来て見て触ってみよう！放射線医療」

    河北新報社　河北ウイークリーせんだい別冊ジュニアr.2024年秋号　9

    2024/09/19

    Type: Promotional material

  11. 第84回日本医学放射線学会「レントゲンの日記念」市民公開講座 「来て見て触ってみよう！放射線医療」

    河北新報社　河北ウイークリーせんだい2024.9.19　9下段

    2024/09/19

    Type: Promotional material

  12. 河北新報「気になる症状すっきり診断」に放射線診断科 科長 高瀬 圭教授の記事が掲載されました

    東北大学病院　お知らせ

    2024/05/24

    Type: Other

  13. 気になる症状 すっきり診断（１６９）なかなか治らない高血圧／特別な治療、必要な例も

    河北新報社　河北新報　朝刊 くらし総合（18）

    2024/05/24

    Type: Newspaper, magazine

  14. 血圧に関する様々な情報を提供する「高血圧チャンネル」

    株式会社デイリースポーツ案内広告社（日本経済新聞）　Biz Life Style仙台版　P7（左上）

    2024/02/23

    Type: Promotional material

  15. 「読売新聞教育ネットワーク主催の高校生向けオンラインセミナー」が読売新聞朝刊に掲載されました

    東北大学大学院医学系研究科・医学部　ニュース

    2024/01/16

    Type: Other

  16. 医療、医師の本質に迫る 高校生向けオンラインセミナー 6大学で

    読売新聞東京本社　読売新聞　27 特別面

    2024/01/15

    Type: Newspaper, magazine

  17. 【宮城】AIの発展と共に放射線科医のニーズはますます高まる‐高瀬圭・東北大学病院放射線診断科教授に聞く◆ Vol.2溝部鈴の『東北大学病院／医学部の現在』

    エムスリー株式会社　m3.com ニュース・医療維新　地域情報（県別）地域ニュース

    2022/12/02

    Type: Internet

  18. 【宮城】放射線診断医が難治性高血圧症の新治療法を開発‐高瀬圭・東北大学病院放射線診断科教授に聞く◆ Vol.1溝部鈴の『東北大学病院／医学部の現在』

    エムスリー株式会社　m3.com ニュース・医療維新　地域ニュース 地域情報（県別）

    2022/11/25

    Type: Internet

    More details Close

    共同研究・競争的資金等の研究課題：経静脈的ラジオ波焼灼による原発性アルドステロン症の低侵襲治療法

  19. 「外科的手術をしなくて済む」 体への負担少ない高血圧の新治療法 東北大学病院

    Yahoo! JAPAN　Yahoo! ニュース

    2022/05/23

    Type: Internet

  20. 「外科的手術をしなくて済む」 体への負担少ない高血圧の新治療法 東北大学病院

    TBS　NEWS DIG(JNN DIG)

    2022/05/23

    Type: Internet

  21. 「外科的手術をしなくて済む」 体への負担少ない高血圧の新治療法 東北大学病院

    tbc東北放送　Nスタみやぎ（TBS NEWS DIG）

    2022/05/23

    Type: Internet

  22. 東北大学大学院医学系研究科放射線診断学分野 高血圧引き起こす疾患の低侵襲治療開発

    関東医事新報社　医事新報　第693号 21 宮城 講座クローズアップ

    2022/02/20

    Type: Newspaper, magazine

  23. 気になる症状 すっきり診断 東北大病院専門ドクターに聞く 113原発性アルドステロン症 副腎の腫瘍 電流で焼灼 ホルモン過剰に

    河北新報社　河北新報（19）くらし

    2021/11/26

    Type: Newspaper, magazine

  24. 難治性高血圧に新治療法 原発性アルドステロン症 原因の腫瘍焼き 根治へ

    長崎新聞社　長崎新聞　健康 10

    2021/10/10

    Type: Newspaper, magazine

  25. 難治性高血圧に新治療法 原発性アルドステロン症で保険適用 東北大教授開発 原因腫瘍を電流で焼く

    株式会社高知新聞社　高知新聞　（17）

    2021/09/17

    Type: Newspaper, magazine

  26. 原発性アルドステロン症 難治性高血圧に新治療法 原因腫瘍 電流で焼き切る

    宮崎日日新聞社　宮崎日日新聞　くらし 21

    2021/09/14

    Type: Newspaper, magazine

  27. 難治性高血圧に新治療法 原発性アルドステロン症 原因の腫瘍を電流で焼く

    埼玉新聞社　埼玉新聞　生活情報 医療 サイエンス（13）

    2021/09/08

    Type: Newspaper, magazine

  28. 原因の腫瘍を電流で焼く 難治性高血圧に新治療法 原発性アルドステロン症 医療保険適用に

    株式会社中日新聞社　東京新聞　健康 2（夕刊）

    2021/09/08

    Type: Newspaper, magazine

  29. 【研究成果】難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ−

    東北大学大学院医学系研究科・医学部　ニュース

    2021/09/08

    Type: Other

  30. 難治性の高血圧症 原発性アルドステロン症 新治療法に保険適用 原因の腫瘍 電流で焼く

    株式会社下野新聞社　下野新聞　くらし 18

    2021/09/07

    Type: Newspaper, magazine

  31. 根治期待の新治療法 原発性アルドステロン症 6月から保険適用 腫瘍を高周波電流で焼く

    株式会社茨城新聞社　茨城新聞　健康生活（16）

    2021/09/02

    Type: Newspaper, magazine

  32. 難治性高血圧に新治療法 原因の腫瘍を電流で除去 原発性アルドステロン症

    新日本海新聞社　日本海新聞　くらし（11）

    2021/09/02

    Type: Newspaper, magazine

  33. 体の負担軽い「高血圧」の新たな治療法

    Yahoo! JAPAN　Yahoo! ニュース

    2021/09/02

    Type: Internet

  34. 特集 高血圧治療の最前線『体の負担軽い「高血圧」の新たな治療法』

    tbc東北放送　Nスタみやぎ

    2021/09/02

    Type: TV or radio program

  35. 難治性高血圧に新治療法 針刺し腫瘍を電流で焼く 原発性アルドステロン症

    千葉日報社　千葉日報（日刊）　健康（12）

    2021/08/29

    Type: Newspaper, magazine

  36. 難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ −

    東北大学病院臨床研究推進センター　プレスリリース

    2021/08/24

    Type: Other

  37. 難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ −

    東北大学　2021年 | プレスリリース・研究成果

    2021/08/24

    Type: Other

  38. 難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ−

    東北大学病院　プレスリリース

    2021/08/24

    Type: Other

  39. ここまで進んだ最新治療「原発性アルドステロン症」のラジオ波焼灼療法

    産経新聞社　夕刊フジ　（8）

    2021/08/17

    Type: Newspaper, magazine

  40. 気になる症状 すっきり診断 東北大病院専門ドクターに聞く 67子宮筋腫と言われたら

    河北新報社　河北新報（20）

    2019/12/06

    Type: Newspaper, magazine

  41. “がんの疑い見落とし”再発防止策進まず その背景は

    NHK　首都圏ネットワーク

    2019/01/21

    Type: TV or radio program

  42. 【気になる症状 すっきり診断 東北大病院専門ドクターに聞く】⑱健診で「腎臓に腫瘍の疑い」

    河北新報社　河北新報（25）

    2017/11/17

    Type: Newspaper, magazine

  43. 河北新報・東北大「東北みらいプロジェクト」高血圧早めの治療を-薬の効かない高血圧に立ち向かう

    河北新報社　河北新報

    2017/03/31

    Type: Newspaper, magazine

  44. 医療機器開発産業の最前線

    東北放送

    2016/10/11

    Type: TV or radio program

  45. みちのくワイド 東北の医療機器製造、好調 復興予算背景に医師と企業連携 福島県、参入・海外進出も支援

    朝日新聞社　朝日新聞　第2宮城 28

    2015/03/03

    Type: Newspaper, magazine

  46. 薬が効かない高血圧への挑戦

    TBS　報道特集

    2014/10/11

    Type: TV or radio program

  47. くらしナビ ライフスタイル「ホルモン原因」高血圧に新治療

    毎日新聞社　毎日新聞　くらしナビ 15

    2014/05/27

    Type: Newspaper, magazine

  48. 高血圧を引き起こす “原発性アルドステロン症” の新たな治療法

    NHK仙台　てれまさむね

    2014/05/20

    Type: TV or radio program

  49. 原発性アルドステロン症の新しい治療

    NHK　ニュース7

    2014/05/18

    Type: TV or radio program

  50. 高血圧症に新治療法 東北大病院 患者の負担減に期待

    讀賣新聞社　讀賣新聞　宮城2 30

    2014/04/18

    Type: Newspaper, magazine

  51. 高血圧引き起こす「原発性アルドステロン症」 東北大新治療法2例臨床

    河北新報社　河北新報

    2014/04/15

    Type: Newspaper, magazine

Show all Show first 5

Academic Activities 4

  1. 第84回 日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』

    AER5階多目的ホール（中小企業活性化センター）

    2024/10/27 - 2024/10/27

    Activity type: Other

    More details Close

    共催 公益社団法人日本医学放射線学会、 東北大学大学院医学系研究科 放射線診断学分野、東北大学病院 後援 宮城県教育委員会、仙台市教育委員会、河北新報社 協賛 アミン株式会社、キヤノンメディカルシステムズ株式会社、コニカミノルタ ジャパン株式会社、テルモ株式会社、株式会社フィリップス・ジャパン、 富士フイルムメディカル株式会社、GEヘルスケア・ジャパン株式会社 協力 公益財団法人 仙台観光国際協会

  2. 東北みらいプロジェクトレクチャーシリーズ「血圧管理で健康長寿」. 薬の効かない高血圧に立ち向かう～放射線診断科医とIVRの挑戦～

    東北大学川内キャンパス

    2017/03/18 - 2017/03/18

  3. 第51回ドクターサーチみやぎ健康セミナー市民公開講座「高血圧～3つのチェックポイント～」

    仙台メディアテーク

    2015/07/12 - 2015/07/12

  4. 高校生向け医療体験プログラム 大学プログラム 未来の医療を創る君へ オンラインセミナー 第1回 東北大学 画像で病気を診て、針と管で治療する―放射線診断医の世界―

    2023/10/07 -

    Activity type: Other

Other 6

  1. 日本核医学会 PET核医学認定医

  2. 心臓血管放射線研究会（幹事）

  3. 日本脈管学会脈管専門医（評議委員）

  4. 日本インターベンショナルラディオロジー学会IVR専門医

  5. 日本超音波医学会専門・指導医

  6. 日本医学放射線学会放射線診断専門・指導医（理事）

Show all Show first 5