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Kei Takase

Section

Graduate School of Medicine

Job title

Professor

Degree

Doctor of Medicine (Tohoku University)
Doctor of Philosophy (Tohoku University)

researchmap

https://researchmap.jp/rad-kei

J-GLOBAL ID

201801002721607420

e-Rad No.

60361094

Research History 12

2023/04 - Present

Tohoku University　School of Medicine　Department Chair, School of Medical Sciences
2015 - Present

東北大学病院　放射線診断科　科長
2015 - Present

Tohoku University　Graduate School of Medicine
2010 - 2015

Tohoku University　Faculty of Medicine
2007 - 2010

Tohoku University　Faculty of Medicine
2003 - 2007

Tohoku University　Faculty of Medicine
2005 - 2006

フンボルト大学シャリテ病院　放射線科　visiting scientist
1997 - 2003

石巻赤十字病院放射線科　部長
1994 - 1997

国立循環器病センター　放射線診療部
1993 - 1994

公立佐沼総合病院　放射線科
1992 - 1993

仙台社会保険病院　放射線科
1989 - 1991

東北大学医学部付属病院　放射線科　研修医

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Education 2

Tohoku University　医学部　医学科

1983 - 1989
栃木県立佐野高校

- 1983

Research Interests 2

Interventional Radiology
Diagnostic Radiology

Research Areas 2

Life sciences / Metabolism and endocrinology /
Life sciences / Radiology / Diagnostic Radiology

Awards 4

Certificate of Merit

2012/11　RSNA (Radiological Society of North America)　What Radiologists Should know and Do for Adrenal Hypertension -Disease Concept, Diagnostic Imaging, Venous Sampling and Interventional Radiological Treatment-
Magna Cum Laude

2012/03　ECR (European Congress of Radiology)　Adrenal venous sampling revisited - Crucial role in the management of primary aldosteronism patients
Certificate of Merit

2005　RSNA (Radiological Society of North America)　Non-thrombotic occlusion of hemodialysis access: Disease concept, Diagnosis, and Intervention.
Certificate of Merit

2003　RSNA (Radiological Society of North America)　How to utilize Color Doppler Ultrasound in IVR of Brescia-Cimino shunt

Papers 421

Partial Pressure of Oxygen-Guided Adrenal Venous Sampling in Primary Aldosteronism. International-journal

Kei Omata, Yuta Tezuka, Hiromitsu Tannai, Yoshikiyo Ono, Hiroshi Ishihata, Hiroki Kamada, Sota Oguro, Yoshihide Kawasaki, Akihiro Ito, Yuto Yamazaki, Hironobu Sasano, Takashi Suzuki, Tetsuhiro Tanaka, Kei Takase, Hideki Katagiri, Fumitoshi Satoh

The Journal of clinical endocrinology and metabolism　2026/03/06

DOI： 10.1210/clinem/dgag089 　

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BACKGROUND: Adrenal venous sampling (AVS) plays a pivotal role in treatment optimization for primary aldosteronism (PA) to minimize the cardiovascular risks. However, technical difficulties often hinder accurate cannulation to the adrenal veins (AVs). This study aimed to explore the distribution of partial pressure of oxygen (pO2) in the adrenal and neighboring veins, inspired by our awareness of lighter red color of adrenal venous blood than the others. METHODS: We enrolled 179 PA patients who underwent AVS from 2021 to 2024. During AVS, we collected residual blood samples from bilateral adrenal, hepatic, inferior phrenic and external iliac veins for blood gas analysis. Statistical analysis was conducted to evaluate pO2 distributions and its associations with clinical parameters. RESULTS: Among 179 patients examined, 168 received oxygen supplementation during AVS and in those cases, the pO2 levels were significantly higher in the bilateral AVs than in the hepatic and inferior phrenic veins at baseline, whereas the levels of partial pressure of carbon dioxide were lower. Following cosyntropin stimulation, the pO2 levels in the AVs decreased but distribution patterns across the examined veins remained similar. The pO2 evaluation provided highly accurate identification of AVs both before and after cosyntropin stimulation. CONCLUSION: This is the first study to examine the pO2 dynamics in the human adrenal and non-adrenal veins, demonstrating its potential to improve AVS cannulation success rates. Our findings also presented the oxygen consumption in the adrenal glands for steroidogenesis. The pO2 measurement is a faster, easier and less-expensive tool enhancing AVS techniques.
Microarteriovenous Fistulas Causing Refractory Skin Ulcers: Feasibility and Safety of Transcatheter Embolization. International-journal

Sota Oguro, Akira Endo, Hiromitsu Tannai, Hideki Ota, Tomomi Sato, Tomoki Sato, Hiroki Kamada, Yosuke Miyachi, Masato Ito, Hiroaki Furukawa, Yumi Kambayashi, Yoshihide Asano, Fukashi Serizawa, Daijirou Akamatsu, Kei Takase, Shigeki Imai

Cardiovascular and interventional radiology　49　(1)　126-132　2026/01

DOI： 10.1007/s00270-025-04234-0 　

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PURPOSE: Microarteriovenous fistulas (m-AVFs) have been proposed as a potential cause of lower limb ulcers that are refractory to standard therapies. This study evaluated the feasibility and safety of transcatheter arterial embolization (TAE) using imipenem/cilastatin sodium (IPM/CS) in patients with m-AVF-related refractory skin ulcers. METHODS: This retrospective study included 17 patients with lower limb refractory skin ulcers treated with TAE from 2013 to 2023. M-AVFs were diagnosed via Doppler and confirmed by angiography. Embolizations were done under local anesthesia through femoral artery access, using imipenem/cilastatin mixed with contrast, injected until flow stagnation or a 0.5 g max. Technical success was defined as the elimination of early venous shunting on angiography. Clinical success was defined as a ≥ 50% reduction in ulcer size. Repeated TAE procedures were performed at 1-2-month intervals when clinical improvement was deemed insufficient, primarily based on physician judgment regarding ulcer size and pain. While no strict quantitative threshold was used, the decision to proceed with additional sessions beyond three was based on discussion between the patient and physician. The outcome evaluation included assessments of ulceration and pain severity. RESULTS: We performed 41 embolizations on 17 patients, with repeat sessions every 1-2 months if needed. Technical success was achieved in all cases (100%). No major complications occurred; minor pain was reported in ~ 20% of cases. Over an average 11.5-month follow-up, clinical success was observed in 88% of patients. CONCLUSION: TAE with IPM/CS is a feasible and safe treatment option for refractory lower limb skin ulcers caused by m-AVFs.
Insular abnormalities in 18F-fluorodeoxyglucose positron emission tomography and risk of fatal ventricular arrhythmic events in patients with cardiac sarcoidosis. International-journal

Yui Chonan, Hideaki Suzuki, Kouki Takeuchi, Kentaro Takanami, Kei Takase, Satoshi Yasuda

International journal of cardiology　441　133814-133814　2025/12/15

DOI： 10.1016/j.ijcard.2025.133814 　

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INTRODUCTION: A clinical significance of extra-cardiac uptake of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET), particularly in the brain, is unclear in cardiac sarcoidosis (CS). METHODS AND RESULTS: We analysed data from 84 CS patients (mean age 58.3 years, 70.2 % woman) who underwent 18F-FDG-PET scans, including brain imaging, between May 2008 and December 2021, with follow-ups completed in July 2023. Brain 18F-FDG-PET images were processed using SPM12 software, with regional brain 18F-FDG uptake normalised to whole-brain uptake. Voxel-wise analysis identified the left insula, whose 18F-FDG uptake was lower in patients who experienced fatal ventricular arrhythmic events (FVAE) (N = 30) compared to those without FVAE (N = 54) (1.15 ± 0.06 vs. 1.20 ± 0.06, P < 0.001). Kaplan-Meier curve analysis showed that patients with lower left-insular 18F-FDG uptake (<1.18) had a higher FVAE incidence compared to those with higher uptake (≥1.18) (P = 0.003). Cox proportional hazard analysis demonstrated that the FVAE risk decreased with a hazard ratio of 0.538 (95 % confidence interval 0.359-0.808) for every 1 standard deviation increase in left-insular 18F-FDG uptake (P = 0.003). Combining both cardiac and brain 18F-FDG uptakes allowed a better discrimination of FVAE risk. CONCLUSIONS: Brain 18F-FDG-PET, particularly evaluating the left insular cortex involved in parasympathetic regulation, may help to assess the FVAE risk in CS patients.
Synthetic X-Q space learning for diffusion MRI parameter estimation: a pilot study in breast DKI. International-journal

Yoshitaka Masutani, Kousei Konya, Erina Kato, Naoko Mori, Hideki Ota, Shunji Mugikura, Kei Takase, Yuki Ichinoseki

International journal of computer assisted radiology and surgery　20　(12)　2423-2435　2025/12

DOI： 10.1007/s11548-025-03550-7 　

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PURPOSE: For diffusion MRI (dMRI) parameter estimation, machine-learning approaches have shown promising results so far including the synthetic Q-space learning (synQSL) based on regressor training with only synthetic data. In this study, we aimed at the development of a new method named synthetic X-Q space learning (synXQSL) to improve robustness and investigated the basic characteristics. METHODS: For training data, local parameter patterns of 3 × 3 voxels were synthesized by a linear combination of six bases, in which parameters are estimated at the center voxel. We prepared three types of local patterns by choosing the number of bases: flat, linear and quadratic. Then, at each location of 3 × 3 voxels, signal values of the diffusion-weighted image were computed by the signal model equation for diffusional kurtosis imaging and Rician noise simulation. The multi-layer perceptron was used for parameter estimation and was trained for each parameter with various noise levels. The level is controlled by a noise ratio defined as a fraction of the standard deviation in the Rician noise distribution normalized by the average b = 0 signal values. Experiments for visual and quantitative validation were performed with synthetic data, a digital phantom and clinical breast datasets in comparison with the previous methods. RESULTS: By using synthetic datasets, synXQSL outperformed synQSL in the parameter estimation of noisy data sets. Through the digital phantom experiments, the combination of synXQSL bases yields different results and a quadratic pattern could be the reasonable choice. The clinical data experiments indicate that synXQSL suppresses noises in estimated parameter maps and consequently brings higher contrast. CONCLUSION: The basic characteristics of synXQSL were investigated by using various types of datasets. The results indicate that synXQSL with the appropriate choice of bases in training data synthesis has the potential to improve dMRI parameters in noisy datasets.
A practical slice averaged image method for precise CT size specific dose estimates. International-journal

Yutaka Dendo, Keisuke Abe, Shu Onodera, Shingo Kayano, Hideki Ota, Kei Takase

Scientific reports　15　(1)　42870-42870　2025/12/01

DOI： 10.1038/s41598-025-27035-4 　

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Computed tomography (CT) is a widely used diagnostic tool, but variations in patient anatomy make accurate radiation dose estimation challenging. While size-specific dose estimates (SSDE) can serve as a more effective tool for dose prediction than conventional indices like CTDIvol and DLP, calculating the water-equivalent diameter (Dw) for each slice is time-consuming and often impractical. To address this, we propose a novel method, the SSDE slice-averaged image (SSDESAI), which calculates Dw from a single image generated by averaging CT values across all slices. This approach captures anatomical variability while reducing calculation effort. We retrospectively analyzed CT data from 282 adult patients in three scan regions: chest, abdomen-pelvis, and chest-abdomen-pelvis (CAP). SSDESAI was compared with SSDEcenter and the reference mean SSDE using regression analysis and root mean square error (RMSE). SSDESAI showed stronger agreement with mean SSDE than SSDEcenter across all regions, achieving R2 values up to 0.991 and lower RMSE. These results suggest that SSDESAI is a more advanced approach for dose prediction and may serve as a practical alternative for routine clinical use.
Detectability of subsegmental lesions in patients with inoperable CTEPH: Comparison between ultra-high-resolution vs. conventional CT. International-journal

Satoshi Higuchi, Taijyu Satoh, Hidenobu Takagi, Mitsuru Nakada, Takuya Kawahara, Nobuhiro Yaoita, Shuhei Sugiyama, Tomoya Onuma, Kenta Shirata, Shingo Kayano, Hideki Ota, Satoshi Yasuda, Kei Takase

JHLT open　10　100344-100344　2025/11

DOI： 10.1016/j.jhlto.2025.100344 　

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BACKGROUND: CT pulmonary angiography (CTPA) plays a critical role in guiding balloon pulmonary angioplasty (BPA) for patients with chronic thromboembolic pulmonary hypertension (CTEPH). However, conventional CT (cCT) has limited sensitivity in detecting peripheral lesions, which is critical for avoiding complications. This study compared ultra-high-resolution CT (UHRCT; 0.25 mm detector elements) and conventional CT (cCT; 0.6 mm detector elements) in identifying and classifying segmental and subsegmental lesions, using invasive selective angiography during BPA as the reference standard. METHODS: This single-center retrospective study included 42 patients with newly diagnosed CTEPH who underwent CT pulmonary angiography (CTPA) with either cCT or UHRCT and subsequently completed BPA. The morphology and location of lesions were independently assessed using selective angiography and CTPA. Sensitivity, specificity, and lesion classification accuracy were assessed using selective angiography as the reference standard. RESULTS: A total of 1687 branches in 42 patients (male/female 11/31, mean age 66 years) were analyzed. The sensitivity and specificity of cCT were 54.6% (95% CI: 48.2-60.8) and 85.2% (95% CI: 75.6-91.4), respectively. In contrast, UHRCT demonstrated significantly higher sensitivity (94.3%, 95% CI: 91.9-96.1) but lower specificity (60.2%, 95% CI: 46.7-72.2). The sensitivity difference was more prominent in subsegmental branches (p for interaction = 0.11). UHRCT more accurately classified lesion types in 83.7% of cases (95% CI: 76.7-88.9), versus 69.1% (95% CI: 58.3-78.1) with cCT. Web lesions remained the most difficult to detect. CONCLUSION: Higher-spatial-resolution CTPA provides a higher lesion detection sensitivity, particularly in subsegmental branches, and more accurately classified lesion type in patients with CTEPH treated with BPA, potentially aiding procedural planning and guidance.
Lipiodol marking for CT-guided radiofrequency ablation of adrenal aldosterone-producing adenomas: a case series. International-journal

Hiromitsu Tannai, Sota Oguro, Hiroyuki Sakakibara, Yumi Nakajima, Hiroki Kamada, Yuta Tezuka, Yoshikiyo Ono, Hideki Ota, Kei Takase

CVIR endovascular　8　(1)　95-95　2025/10/28

DOI： 10.1186/s42155-025-00614-2 　

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BACKGROUND: Tumor visualization during computed tomography (CT)-guided radiofrequency ablation (RFA) of adrenal adenomas is often limited by the small size of the lesion and needle-induced artifacts. These limitations can impair accurate needle placement and increase the risk of incomplete ablation. This report shows four adrenal RFA procedures in which iodized oil (Lipiodol®) marking enhanced lesion visibility. CASE PRESENTATION: CT imaging and adrenal venous sampling showed unilateral right aldosterone-producing adenomas measuring 10-20 mm in patients with primary aldosteronism. Contrast enhancement of the nodules was confirmed via CT angiography after microcatheter insertion into the adrenal artery. Transarterial embolization was performed utilizing a 1:1 mixture of Lipiodol and iohexol. In three cases, Lipiodol deposition within the adenomas was confirmed on CT immediately post-embolization and persisted on the following day. Despite needle-induced artifacts during RFA, nodule visibility significantly improved. RFA was completed without major complications, which resulted in the resolution of primary aldosteronism and hypertension. In one case, although Lipiodol marking was discontinued due to the extravasation from the adrenal artery branch, RFA was completed on the following day. CONCLUSIONS: CT-guided RFA with Lipiodol marking facilitated the effective treatment of aldosterone-producing adrenal adenomas in three patients by significantly enhancing lesion visibility. Adrenal arterial embolization should be addressed with caution to avoid damaging the small blood vessels of the adrenal gland.
ステントグラフト遠位端の解離がretrograde type A dissectionに至った1例

佐藤章広, 高木英誠, 熊谷紀一郎, 齋木佳克, 大田英揮, 高瀬圭

日本医学放射線学会秋季臨床大会抄録集　61回　S530-S530　2025/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Case series: Occlusion using gelatin sponge in modified coil-assisted retrograde transvenous obliteration (Og-CARTO) for the treatment of portal hypertensive varices

Shin Chibana, Hiroyuki Sakakibara, Sota Oguro, Takuma Usuzaki, Hiroki Kamada, Hiromitsu Tannai, Kei Takase

Radiology Case Reports　20　(8)　3666-3674　2025/08
Publisher: Elsevier BV
DOI： 10.1016/j.radcr.2025.04.073 　

ISSN： 1930-0433
The Utility of a Modified Data-Driven Motion Correction Method Incorporating Computed Tomography Positional Data for Positron Emission Tomography.

Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Nao Yamaguchi, Hirofumi Kawakami, Akie Katsuki, Yoshitaka Tanaka, Takashi Takeuchi, Hiroyasu Kodama, Akihito Usui, Kei Takase, Tomohiro Kaneta

The Tohoku journal of experimental medicine　2025/06/12

DOI： 10.1620/tjem.2025.J072 　
Case Report: Anomalous drainage vein sampling for diagnosing aldosterone-producing lesions undetectable by segmental adrenal venous sampling in a two-case series

Hiromitsu Tannai, Sota Oguro, Hiroki Kamada, Yuta Tezuka, Yoshikiyo Ono, Kei Omata, Kei Takase

FRONTIERS IN RADIOLOGY　5　2025/06/10

DOI： 10.3389/fradi.2025.1567779 　

eISSN： 2673-8740
An Indolent Aldosterone-Producing Adenoma in a Young Hypertensive Patient Manifested during 7-Year Follow-up.

Yuta Tezuka, Yoshikiyo Ono, Yuto Yamazaki, Satoshi Higuchi, Jun Nishikawa, Kei Omata, Sota Oguro, Hideki Ota, Kei Takase, Yoshihide Kawasaki, Akihiro Ito, Takashi Suzuki, Hironobu Sasano, Tetsuhiro Tanaka, Fumitoshi Satoh

The Tohoku journal of experimental medicine　2025/05/29

DOI： 10.1620/tjem.2025.J060 　
PlaNet-S: an Automatic Semantic Segmentation Model for Placenta Using U-Net and SegNeXt. International-journal

Isso Saito, Shinnosuke Yamamoto, Eichi Takaya, Ayaka Harigai, Tomomi Sato, Tomoya Kobayashi, Kei Takase, Takuya Ueda

Journal of imaging informatics in medicine　2025/05/27

DOI： 10.1007/s10278-025-01549-9 　

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This study aimed to develop a fully automated semantic placenta segmentation model that integrates the U-Net and SegNeXt architectures through ensemble learning. A total of 218 pregnant women with suspected placental abnormalities who underwent magnetic resonance imaging (MRI) were enrolled, yielding 1090 annotated images for developing a deep learning model for placental segmentation. The images were standardized and divided into training and test sets. The performance of Placental Segmentation Network (PlaNet-S), which integrates U-Net and SegNeXt within an ensemble framework, was assessed using Intersection over Union (IoU) and counting connected components (CCC) against the U-Net, U-Net + + , and DS-transUNet. PlaNet-S had significantly higher IoU (0.78, SD = 0.10) than that of U-Net (0.73, SD = 0.13) (p < 0.005) and DS-transUNet (0.64, SD = 0.16) (p < 0.005), while the difference with U-Net + + (0.77, SD = 0.12) was not statistically significant. The CCC for PlaNet-S was significantly higher than that for U-Net (p < 0.005), U-Net + + (p < 0.005), and DS-transUNet (p < 0.005), matching the ground truth in 86.0%, 56.7%, 67.9%, and 20.9% of the cases, respectively. PlaNet-S achieved higher IoU than U-Net and DS-transUNet, and comparable IoU to U-Net + + . Moreover, PlaNet-S significantly outperformed all three models in CCC, indicating better agreement with the ground truth. This model addresses the challenges of time-consuming physician-assisted manual segmentation and offers the potential for diverse applications in placental imaging analyses.
Imaging of cerebrospinal fluid leakage from the cribriform plate. International-journal

Tomoki Sato, Yohei Morishita, Jun Suzuki, Ryu Narita, Keisei Uehara, Erina Kato, Kei Takase

Radiology case reports　20　(4)　1920-1924　2025/04

DOI： 10.1016/j.radcr.2025.01.004 　

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Cerebrospinal fluid leakage from the skull base occurs when the subarachnoid space communicates with the extracranial space. Cerebrospinal fluid leakage from the cribriform plate is often difficult to diagnose because the fistula is small. If the fistula can be identified before surgery, this can contribute greatly to treatment. We present 2 cases of cerebrospinal fluid leakage from the cribriform plate with tiny fistulas, which we were able to diagnose before surgery with CT and MRI.
Diagnosis and Treatment of Postoperative Hepatic Lymphorrhea.

Tetsuya Hasegawa, Masanori Inoue, Masahiro Tsuboi, Kei Takase

Interventional radiology (Higashimatsuyama-shi (Japan)　10　e20230042　2025/03/28

DOI： 10.22575/interventionalradiology.2023-0042 　

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Postoperative hepatic lymphorrhea is a rare complication that can lead to refractory ascites. During surgery with lymph node dissection of the hepatoduodenal ligament, leakage of liver lymph into the abdominal cavity can occur. Due to the development of interventional radiology for various lymphatic leaks in recent years, the pathogenesis of hepatic lymphatic leakage has become more evident. Percutaneous transhepatic lymphangiography is important for the diagnosis of hepatic lymphorrhea. Although there have been case reports of percutaneous embolization and sclerotherapy treatments for hepatic lymphorrhea in recent years, there have been no case studies. However, the standard treatment for this condition remains unknown. This study discusses the anatomy of hepatic lymphatics and the pathogenesis, diagnosis, and treatment of hepatic lymphorrhea, including the latest literature on interventional radiology.
原発性アルドステロン症における副腎静脈サンプリングの成功に対する血液ガス分析の有用性(Utility of Blood Gas Analysis for Successful Adrenal Venous Sampling in PrimaryAldosteronism)

Tannai Hiromitsu, Tezuka Yuta, Omata Kei, Ono Yoshikiyo, Kamada Hiroki, Sota Oguro, Ota Hideki, Sato Fumitoshi, Katagiri Hideki, Takase Kei

日本医学放射線学会学術集会抄録集　84回　S239-S239　2025/03
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Identification of Adamkiewicz artery by 4D flow MRI and intra-arterial ultra-high-resolution CT angiography in preoperative assessment of patients with chronic aortic dissection: A case report

Satoshi Higuchi, Yuta Sato, Hideki Ota, Ryuichi Mori, Yuki Ichinoseki, Hitoshi Nemoto, Shingo Kayano, Kiichiro Kumagai, Yoshikatsu Saiki, Kei Takase

Radiology Case Reports　20　(3)　1581-1585　2025/03
Publisher: Elsevier BV
DOI： 10.1016/j.radcr.2024.12.001 　

ISSN： 1930-0433
Reduced 18F-FDG uptake in the basal interventricular septum as a predictor of fatal ventricular arrhythmic events in patients with cardiac sarcoidosis. International-journal

Kouki Takeuchi, Hideaki Suzuki, Kentaro Takanami, Hideki Ota, Yoshitaka Tanaka, Fumiyoshi Fujishima, Hirofumi Watanabe, Kai Susukita, Takumi Inoue, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Takashi Suzuki, Kei Takase, Satoshi Yasuda

International journal of cardiology　419　132686-132686　2025/01/15

DOI： 10.1016/j.ijcard.2024.132686 　

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BACKGROUND: Patients with cardiac sarcoidosis (CS) are at an increased risk of fatal ventricular arrhythmic events (FVAE). However, the predictive value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in assessing the risk of FVAE in patients with CS remains uncertain. METHODS: We included data from 121 patients with CS (39 men and 82 women; mean age: 59.5 years) who underwent FDG-PET imaging between March 2008 and November 2020, with follow-ups completed in July 2023. Of these, 82 patients had available cardiac magnetic resonance imaging data, including late gadolinium enhancement (LGE). FDG-PET images were analysed using a polar-map model to determine the regional mean percentage uptake relative to the maximal cardiac 18F-FDG uptake in each of the 17 segments defined by the American Heart Association. RESULTS: Patients experiencing FVAE after FDG-PET (n = 43) showed lower percent uptake in the basal inferoseptal segment compared to those who did not (n = 78) (41.8 ± 15.2 % vs. 54.4 ± 13.8 %, P < 0.001). Patients with a basal inferoseptal percent uptake below the median had a lower FVAE-free survival rate than those with a higher percent uptake (58.1 % vs. 78 % at 5 years, P = 0.007), which was consistent in patients with LGE in the same regions with reduced 18F-FDG uptake. A Cox hazard model indicated that the FVAE risk decreased with a hazard ratio of 0.862 (95 % CI 0.770-0.964) for every 5 % increase in basal inferoseptal percent uptake (P = 0.009). CONCLUSION: Reduced 18F-FDG uptake in the basal interventricular septum, including the inferoseptal segment, may be a valuable predictor of future FVAE in patients with CS.
Case Report: Anomalous drainage vein sampling for diagnosing aldosterone-producing lesions undetectable by segmental adrenal venous sampling in a two-case series. International-journal

Hiromitsu Tannai, Sota Oguro, Hiroki Kamada, Yuta Tezuka, Yoshikiyo Ono, Kei Omata, Kei Takase

Frontiers in radiology　5　1567779-1567779　2025

DOI： 10.3389/fradi.2025.1567779 　

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Adrenal vein sampling (AVS) is the gold standard for subtyping primary aldosteronism (PA). However, through conventional AVS, unilateral PA may be misdiagnosed as bilateral PA. Compared with conventional AVS, segmental AVS with additional sampling in adrenal tributaries can detect aldosterone-producing adenomas (APAs) with higher sensitivity. Herein, we describe two cases wherein high aldosterone levels were not detected through initial segmental AVS but were identified in anomalous drainage veins during the second AVS session. In Case 1, computed tomography (CT) during left adrenal arteriovenography revealed a fine renal capsular vein connecting an adrenal nodule to the third lumbar vein. Sampling in this vein during the second AVS revealed high aldosterone levels. The surgical specimen showed the presence of an 11 mm APA. Furthermore, Case 2 presented with bilateral small adrenal nodules; bilateral renal capsular vein sampling was performed during the second AVS session. The samples from the renal capsular vein connected to the renal vein revealed considerably high aldosterone levels. Left adrenalectomy revealed the presence of a 6 mm aldosterone-producing nodule. These cases highlight the importance of anomalous drainage vein sampling, the limitation of conventional and segmental AVS in diagnosing PA, and the utility of CT during adrenal arteriovenography for estimating the drainage route.
Magnetic Resonance Imaging Texture Analysis Based on Intraosseous and Extraosseous Lesions to Predict Prognosis in Patients with Osteosarcoma

Yu Mori, Hainan Ren, Naoko Mori, Munenori Watanuki, Shin Hitachi, Mika Watanabe, Shunji Mugikura, Kei Takase

Diagnostics　2024/11/15

DOI： 10.3390/diagnostics14222562 　
Role of radiologists in the diagnosis and management of adrenal disorders.

Sota Oguro, Hiromitsu Tannai, Hideki Ota, Kazumasa Seiji, Hiroki Kamada, Yoshitaka Toyama, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh, Sadayoshi Ito, Tetsuhiro Tanaka, Hideki Katagiri, Kei Takase

Endocrine journal　2024/10/10

DOI： 10.1507/endocrj.EJ24-0156 　

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This study aimed to focus on the role of radiologists in the diagnosis and management of adrenal lesions, particularly primary aldosteronism (PA) and secondary hypertension. As hypertension affects more than one-third of the population in Japan, identifying secondary causes such as PA and adrenal lesions is crucial. Establishing a radiological differential diagnosis of adrenal lesions using advanced imaging techniques, such as computed tomography and magnetic resonance imaging, is crucial. Knowledge of the imaging findings of various benign and malignant adrenal lesions, such as adrenocortical adenomas, cortisol-producing lesions, pheochromocytomas, adrenocortical carcinoma, malignant lymphoma, and metastatic tumors, is necessary. Adrenal venous sampling (AVS) plays a crucial role in accurately localizing aldosterone hypersecretion in PA, especially when imaging fails to provide a clear diagnosis. This paper details the technical aspects of AVS, emphasizing catheterization techniques, anatomical considerations, and the importance of preprocedural imaging for successful sampling. Furthermore, we explore segmental adrenal venous sampling (SAVS), a more refined technique that samples specific adrenal tributary veins, offering enhanced diagnostic accuracy, particularly for microadenomas or challenging cases that may be missed with conventional AVS. The methodology for performing SAVS, along with the interpretation criteria for successful sampling and lateralization, is also outlined. Furthermore, radiologists have initiated treatments for unilateral PA, such as radiofrequency ablation, and play an integral role in the management of adrenal lesions. Collaborative approaches across clinical departments are required to enhance patient management in medical care involving the adrenal gland.
Introduction and evaluation of size-specific DLP for radiation dose estimation in CT examinations. International-journal

Yutaka Dendo, Keisuke Abe, Shu Onodera, Shingo Kayano, Hideki Ota, Kei Takase

Journal of radiological protection : official journal of the Society for Radiological Protection　2024/10/09

DOI： 10.1088/1361-6498/ad8500 　

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The increased utilization of computed tomography (CT) has raised concerns about patient radiation exposure. Effective dose (ED), which requires precise estimation, is crucial for assessing and managing these risks. Traditional ED estimation methods, which are based on the dose-length product (DLP), often lack accuracy due to variations in patient size and anatomy. This study aims to evaluate the efficacy of size-specific DLP (SS-DLP), a novel metric that combines the size-specific dose estimate (SSDE) with scan length, to provide a more accurate estimation of radiation exposure from CT examinations. Focusing on adult chest-abdomen-pelvis (CAP) scans, we calculated SSDE and SS-DLP and utilized two simulation tools, Radimetrics and WAZA-ARI, for a detailed analysis. Our findings indicate that SS-DLP is highly correlated with EDs from Monte Carlo simulations, suggesting its reliability. Additionally, SS-DLP showed a moderate reduction in errors based on patient sex and body mass index compared to traditional DLP-based methods. Thus, SS-DLP offers a more accurate and personalized radiation exposure estimate, potentially enhancing patient safety.
Improving Balloon Pulmonary Angioplasty Through Target Endpoint Optimization With Pressure Catheter and Angiographic Lung Perfusion

Taijyu Satoh, Nobuhiro Yaoita, Satoshi Higuchi, Kotaro Nochioka, Saori Yamamoto, Haruka Sato, Kaito Yamada, Yusuke Yamada, Kohei Komaru, Naoki Chiba, Mitsuru Nakada, Satoshi Miyata, Hideki Ota, Kei Takase, Satoshi Yasuda

JACC: Cardiovascular Interventions　17　(20)　2394-2407　2024/10
Publisher: Elsevier BV
DOI： 10.1016/j.jcin.2024.08.045 　

ISSN： 1936-8798
Cost-effectiveness analysis of segmental adrenal venous sampling with radiofrequency ablation for primary aldosteronism in Japan

Satoru Yanagaki, Kei Omata, Sota Oguro, Hideki Ota, Tomomi Sato, Hiroki Kamada, Hiromitsu Tannai, Yuta Tezuka, Yoshikiyo Ono, Miho Sato, Hiroyuki Ohbe, Kei Takase

Japanese Journal of Radiology　2024/09/25
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11604-024-01665-6 　

ISSN： 1867-1071

eISSN： 1867-108X

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Abstract Purpose The purpose of this study was to evaluate the cost-effectiveness of comprehensive treatment strategy, including segmental adrenal venous sampling (sAVS) and radiofrequency ablation (RFA), versus medication-only strategy for primary aldosteronism. Materials and methods A Markov decision model was developed to compare the cost-effectiveness of a comprehensive treatment strategy and a medication-only strategy for 50-year-old men and women with stage I–III hypertension. The comprehensive treatment strategy included aldosterone/renin ratio measurement, two loading tests, computed tomography, sAVS, drugs, surgery, and RFA. We built a model with a yearly cycle over 32- and 38-year time horizons for men and women, respectively, and four health states: hypertension, heart failure, stroke, and death. The incremental cost-effectiveness ratio (ICER), expressed as Japanese yen per quality-adjusted life-years (QALYs), was estimated, and strategy preference was determined on the basis of 5 million Japanese yen per QALY societal willingness-to-pay threshold. Results The ICERs of the comprehensive treatment strategy over the medication-only strategy were 201,482 and 3,399 JPY per QALY for men and women, respectively. The resultant ICER was less than the 5 million JPY societal willingness-to-pay threshold. Deterministic sensitivity analysis and probabilistic sensitivity analysis revealed that the results varied with the input values, but the comprehensive strategy was likely to be more cost-effective than the medication-only strategy. Conclusion This cost-effectiveness study revealed that a comprehensive treatment strategy including sAVS and RFA was favorable compared with the medication-only strategy for managing stage I–III hypertension in 50-year-old men and women, with acceptable willingness-to-pay thresholds. Secondary abstract This cost-effectiveness study revealed that a comprehensive treatment strategy for primary aldosteronism that included segmental adrenal sampling and radiofrequency ablation was favorable compared with the medication-only strategy for managing stage I–III hypertension in 50-year-old men and women, with acceptable willingness-to-pay thresholds.
Prophylactic splenic artery embolization using n-butyl-2-cyanoacrylate and coils prior to endoscopic necrosectomy in a patient with necrotizing pancreatitis: A case report. International-journal

Hiroki Kamada, Sota Oguro, Tatsuro Fukushi, Hiromitsu Tannai, Hideki Ota, Kei Takase

Radiology case reports　19　(8)　3483-3487　2024/08

DOI： 10.1016/j.radcr.2024.05.027 　

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We present a case of prophylactic endovascular embolization in a 51-year-old man with necrotizing pancreatitis (NP) before undergoing endoscopic necrosectomy (EN). Contrast-enhanced CT imaging revealed the presence of a walled-off necrosis (WON) surrounding the pancreas, with the splenic artery coursing through the cavity. The splenic artery was embolized using n-butyl-2-cyanoacrylate (NBCA) and coils to mitigate the risk of massive bleeding in EN. A newly developed polytetrafluoroethylene (PTFE)-coated microcatheter was used to inject NBCA, enabling embolization of a long segment of the splenic artery without adhering to the vessel wall. Coils were placed distal and proximal to the embolized segment to optimize control. Over 5 sessions of EN, no massive bleeding was encountered. This report demonstrates the benefits of utilizing PTFE-coated microcatheters for enhanced safety and maneuverability during embolization with NBCA. Furthermore, it highlights the importance of prophylactic embolization during EN for managing NP.
Two-session embolization of portosystemic shunt presenting with hepatic encephalopathy via transvenous and trans-paraumbilical approaches: A case report. International-journal

Hiroki Kamada, Tomomi Sato, Sota Oguro, Hideki Ota, Kei Takase

Radiology case reports　19　(6)　2112-2116　2024/06

DOI： 10.1016/j.radcr.2024.02.057 　

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We describe the endovascular embolization of a 65-year-old man with chronic hepatic encephalopathy. A contrast-enhanced computed tomography demonstrated a splenorenal shunt and a recanalized paraumbilical vein as a continuous portal shunt connecting the left branch of the portal vein and the right common femoral vein. A 2-session embolization was performed for the splenorenal shunt. First, the transvenous approach was used for coil embolization of the splenorenal shunt. It was difficult to advance the catheter system to the embolization site, and it was unstable during coil placement. Second, the paraumbilical venous approach was used to place additional coils. The catheter system had good maneuverability and easily reached the embolization site. Additionally, the stable system allowed for densely packed additional coil implantations. This report demonstrated the paraumbilical venous approach's effectiveness in catheter maneuverability and system stability during coil embolization.
Predicting isocitrate dehydrogenase status among adult patients with diffuse glioma using patient characteristics, radiomic features, and magnetic resonance imaging: Multi-modal analysis by variable vision transformer. International-journal

Takuma Usuzaki, Ryusei Inamori, Takashi Shizukuishi, Yohei Morishita, Hidenobu Takagi, Mami Ishikuro, Taku Obara, Kei Takase

Magnetic resonance imaging　2024/05/28

DOI： 10.1016/j.mri.2024.05.012 　

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OBJECTIVES: To evaluate the performance of the multimodal model, termed variable Vision Transformer (vViT), in the task of predicting isocitrate dehydrogenase (IDH) status among adult patients with diffuse glioma. MATERIALS AND METHODS: vViT was designed to predict IDH status using patient characteristics (sex and age), radiomic features, and contrast-enhanced T1-weighted images (CE-T1WI). Radiomic features were extracted from each enhancing tumor (ET), necrotic tumor core (NCR), and peritumoral edematous/infiltrated tissue (ED). CE-T1WI were split into four images and input to vViT. In the training, internal test, and external test, 271 patients with 1070 images (535 IDH wildtype, 535 IDH mutant), 35 patients with 194 images (97 IDH wildtype, 97 IDH mutant), and 291 patients with 872 images (436 IDH wildtype, 436 IDH mutant) were analyzed, respectively. Metrics including accuracy and AUC-ROC were calculated for the internal and external test datasets. Permutation importance analysis combined with the Mann-Whitney U test was performed to compare inputs. RESULTS: For the internal test dataset, vViT correctly predicted IDH status for all patients. For the external test dataset, an accuracy of 0.935 (95% confidence interval; 0.913-0.945) and AUC-ROC of 0.887 (0.798-0.956) were obtained. For both internal and external test datasets, CE-T1WI ET radiomic features and patient characteristics had higher importance than other inputs (p < 0.05). CONCLUSIONS: The vViT has the potential to be a competent model in predicting IDH status among adult patients with diffuse glioma. Our results indicate that age, sex, and CE-T1WI ET radiomic features have key information in estimating IDH status.
右副腎皮質髄質混合腫瘍と左副腎腫瘍によるサブクリニカルクッシング症候群を合併した一例

小林雅幸, 小野美澄, 宍戸愛, 矢浦一磨, 沼畑貴生, 佐藤俊宏, 黒澤聡子, 久保晴丸, 手塚雄太, 尾股慧, 山崎有人, 高瀬圭, 伊藤明宏, 鈴木貴, 片桐秀樹

日本内分泌学会雑誌　100　(1)　341-341　2024/05
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
Grading diffuse glioma based on 2021 WHO grade using self-attention-base deep learning architecture: variable Vision Transformer (vViT)

Takuma Usuzaki, Kengo Takahashi, Ryusei Inamori, Yohei Morishita, Hidenobu Takagi, Takashi Shizukuishi, Yoshitaka Toyama, Mirei Abe, Mami Ishikuro, Taku Obara, Kazuhiro Majima, Kei Takase

Biomedical Signal Processing and Control　91　2024/05

DOI： 10.1016/j.bspc.2024.106001 　

ISSN： 1746-8094

eISSN： 1746-8108
Screening Cutoff Values for the Detection of Aldosterone-Producing Adenoma by LC-MS/MS and a Novel Noncompetitive CLEIA. International-journal

Yoshikiyo Ono, Yuta Tezuka, Kei Omata, Ryo Morimoto, Yuto Yamazaki, Sota Oguro, Kei Takase, Akihiro Ito, Tatsunari Yoshimi, Satoshi Kojima, Sadayoshi Ito, Hironobu Sasano, Takashi Suzuki, Tetsuhiro Tanaka, Hideki Katagiri, Fumitoshi Satoh

Journal of the Endocrine Society　8　(6)　bvae080　2024/04/06

DOI： 10.1210/jendso/bvae080 　

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CONTEXT: Detecting patients with surgically curable aldosterone-producing adenoma (APA) among hypertensive individuals is clinically pivotal. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the ideal method of measuring plasma aldosterone concentration (PAC) because of the inaccuracy of conventional chemiluminescent enzyme immunoassay (CLEIA). However, LC-MS/MS is expensive and requires expertise. We have developed a novel noncompetitive CLEIA (NC-CLEIA) for measuring PAC in 30 minutes. OBJECTIVE: This work aimed to validate NC-CLEIA PAC measurements by comparing them with LC-MS/MS measurements and determining screening cutoffs for both measurements detecting APA. METHODS: We retrospectively measured PAC using LC-MS/MS and NC-CLEIA in 133 patients with APA, 100 with bilateral hyperaldosteronism, and 111 with essential hypertension to explore the accuracy of NC-CLEIA PAC measurements by comparing with LC-MS/MS measurements and determined the cutoffs for detecting APA. RESULTS: Passing-Bablok analysis revealed that the values by NC-CLEIA (the regression slope, intercept, and correlation coefficient were 0.962, -0.043, and 0.994, respectively) were significantly correlated and equivalent to those by LC-MS/MS. Bland-Altman plot analysis of NC-CLEIA and LC-MS/MS also demonstrated smaller systemic errors (a bias of -0.348 ng/dL with limits of agreement of -4.390 and 3.694 within a 95% CI) in NC-CLEIA than LC-MS/MS. The receiver operating characteristic analysis demonstrated that cutoff values for aldosterone/renin activity ratio obtained by LC-MS/MS and NC-CLEIA were 31.2 and 31.5 (ng/dL per ng/mL/hour), with a sensitivity of 91.0% and 90.2% and specificity of 75.4% and 76.8%, respectively, to differentiate APA from non-APA. CONCLUSION: This newly developed NC-CLEIA for measuring PAC could serve as a clinically reliable alternative to LC-MS/MS.
原発性アルドステロン症治療の衆知を集める(最適な治療の解は?) 腹腔鏡下副腎摘除術が原発性アルドステロン症患者のQOL、心機能に与える影響

川崎芳英, 祢津晋久, 手塚ゆうた, 小野美澄, 尾股慧, 小黒草太, 方山博路, 佐竹洋平, 佐藤琢磨, 川守田直樹, 山下慎一, 高瀬圭, 佐藤文俊, 片桐秀樹, 伊藤明宏

日本内分泌外科学会雑誌　41　(Suppl.1)　S136-S136　2024/04
Publisher: (一社)日本内分泌外科学会
ISSN： 2434-6535

eISSN： 2758-8785
初診時に高レニン高アルドステロン血症を呈した片側性原発性アルドステロン症の一例

手塚雄太, 矢浦一磨, 久保晴丸, 尾股慧, 小野美澄, 菅原明, 高瀬圭, 伊藤明宏, 山崎有人, 鈴木貴, 片桐秀樹

日本内分泌学会雑誌　99　(5)　1501-1501　2024/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
Identifying key factors for predicting O6-Methylguanine-DNA methyltransferase status in adult patients with diffuse glioma: a multimodal analysis of demographics, radiomics, and MRI by variable Vision Transformer. International-journal

Takuma Usuzaki, Kengo Takahashi, Ryusei Inamori, Yohei Morishita, Takashi Shizukuishi, Hidenobu Takagi, Mami Ishikuro, Taku Obara, Kei Takase

Neuroradiology　2024/03/12

DOI： 10.1007/s00234-024-03329-8 　

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PURPOSE: This study aimed to perform multimodal analysis by vision transformer (vViT) in predicting O6-methylguanine-DNA methyl transferase (MGMT) promoter status among adult patients with diffuse glioma using demographics (sex and age), radiomic features, and MRI. METHODS: The training and test datasets contained 122 patients with 1,570 images and 30 patients with 484 images, respectively. The radiomic features were extracted from enhancing tumors (ET), necrotic tumor cores (NCR), and the peritumoral edematous/infiltrated tissues (ED) using contrast-enhanced T1-weighted images (CE-T1WI) and T2-weighted images (T2WI). The vViT had 9 sectors; 1 demographic sector, 6 radiomic sectors (CE-T1WI ET, CE-T1WI NCR, CE-T1WI ED, T2WI ET, T2WI NCR, and T2WI ED), 2 image sectors (CE-T1WI, and T2WI). Accuracy and area under the curve of receiver-operating characteristics (AUC-ROC) were calculated for the test dataset. The performance of vViT was compared with AlexNet, GoogleNet, VGG16, and ResNet by McNemar and Delong test. Permutation importance (PI) analysis with the Mann-Whitney U test was performed. RESULTS: The accuracy was 0.833 (95% confidence interval [95%CI]: 0.714-0.877) and the area under the curve of receiver-operating characteristics was 0.840 (0.650-0.995) in the patient-based analysis. The vViT had higher accuracy than VGG16 and ResNet, and had higher AUC-ROC than GoogleNet (p<0.05). The ED radiomic features extracted from the T2-weighted image demonstrated the highest importance (PI=0.239, 95%CI: 0.237-0.240) among all other sectors (p<0.0001). CONCLUSION: The vViT is a competent deep learning model in predicting MGMT status. The ED radiomic features of the T2-weighted image demonstrated the most dominant contribution.
Investigating the cut-off values of captopril challenge test for primary aldosteronism using the novel chemiluminescent enzyme immunoassay method: a retrospective cohort study. International-journal

Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kengo Kambara, Hiroki Kamada, Sota Oguro, Yuto Yamazaki, Celso E Gomez-Sanchez, Akihiro Ito, Hironobu Sasano, Kei Takase, Tetsuhiro Tanaka, Hideki Katagiri, Fumitoshi Satoh

Hypertension research : official journal of the Japanese Society of Hypertension　2024/03/08

DOI： 10.1038/s41440-024-01594-x 　

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The measurement evolution enabled more accurate evaluation of aldosterone production in hypertensive patients. However, the cut-off values for novel assays have been not sufficiently validated. The present study was undertaken to validate the novel chemiluminescent enzyme immunoassay for aldosterone in conjunction with other methods. Moreover, we also aimed to establish a new cut-off value for primary aldosteronism in the captopril challenge test using the novel assay. First, we collected 390 plasma samples, in which aldosterone levels measured using liquid chromatography-mass spectrometry ranged between 0.18 and 1346 ng/dL. The novel chemiluminescent enzyme immunoassay showed identical correlation of plasma aldosterone with liquid chromatography-mass spectrometry, in contrast to conventional radioimmunoassay. Further, we enrolled 299 and 39 patients with primary aldosteronism and essential hypertension, respectively. Plasma aldosterone concentrations measured using the novel assay were lower than those measured by radioimmunoassay, which resulted in decreased aldosterone-to-renin ratios. Subsequently, positive results of the captopril challenge test based on radioimmunoassay turned into "negative" based on the novel assay in 45% patients with primary aldosteronism, using the conventional cut-off value (aldosterone-to-renin activity ratio > 20 ng/dL per ng/mL/h). Receiver operating characteristic curve analysis demonstrated that aldosterone-to-renin activity ratios > 8.2 ng/dL per ng/mL/h in the novel assay was compatible with the conventional diagnosis (sensitivity, 0.874; specificity, 0.980). Our study indicates the great measurement accuracy of the novel chemiluminescent enzyme immunoassay for aldosterone, and the importance of measurement-adjusted cut-offs in the diagnosis of primary aldosteronism.
心臓サルコイドーシス患者の致死的心室不整脈イベント予測における心筋18F-FDG PETの予後予測能(Prognostic Value of Cardiac 18F-fluorodeoxyglucose Positron Emission Tomography in Predicting Fatal Ventricular Arrhythmic Events among Patients with Cardiac Sarcoidosis)

Takeuchi Kouki, Suzuki Hideaki, Takanami Kentaro, Tanaka Yoshitaka, Susukita Kai, Inoue Takumi, Arai Marina, Hayashi Hideka, Nochioka Kotaro, Takahama Hiroyuki, Takase Kei, Yasuda Satoshi

日本循環器学会学術集会抄録集　88回　OE27-7　2024/03
Publisher: (一社)日本循環器学会
当院で経験したlymphomatosis cerebriの画像所見に関する検討

阿部未玲, 森下陽平, 遠藤成, 山森瑛子, 加藤恵里奈, 李麗, 佐藤志帆, 梅津篤司, 麦倉俊司, 高瀬圭

Japanese Journal of Radiology　42　(Suppl.)　9-9　2024/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
治療困難が予想される肝性脳症に対し,複数回IVRを行い奏功した2例

中山愛子, 佐藤友美, 鎌田裕基, 青木英和, 大田英揮, 小黒草太, 高瀬圭, 穴場比奈野

Japanese Journal of Radiology　42　(Suppl.)　9-9　2024/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
Verification of the effect of data-driven brain motion correction on PET imaging. International-journal

Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Kazuma Akimoto, Akihito Usui, Hirofumi Kawakami, Akie Katsuki, Nozomu Uetake, Yutaka Dendo, Yoshitaka Tanaka, Hiroyasu Kodama, Kei Takase, Tomohiro Kaneta

PloS one　19　(7)　e0301919　2024

DOI： 10.1371/journal.pone.0301919 　

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INTRODUCTION: Brain positron emission tomography/computed tomography (PET/CT) scans are useful for identifying the cause of dementia by evaluating glucose metabolism in the brain with F-18-fluorodeoxyglucose or Aβ deposition with F-18-florbetaben. However, since imaging time ranges from 10 to 30 minutes, movements during the examination might result in image artifacts, which interfere with diagnosis. To solve this problem, data-driven brain motion correction (DDBMC) techniques are capable of performing motion corrected reconstruction using highly accurate motion estimates with high temporal resolution. In this study, we investigated the effectiveness of DDBMC techniques on PET/CT images using a Hoffman phantom, involving continuous rotational and tilting motion, each expanded up to approximately 20 degrees. MATERIALS AND METHODS: Listmode imaging was performed using a Hoffman phantom that reproduced rotational and tilting motions of the head. Brain motion correction processing was performed on the obtained data. Reconstructed images with and without brain motion correction processing were compared. Visual evaluations by a nuclear medicine specialist and quantitative parameters of images with correction and reference still images were compared. RESULTS: Normalized Mean Squared Error (NMSE) results demonstrated the effectiveness of DDBMC in compensating for rotational and tilting motions during PET imaging. In Cases 1 and 2 involving rotational motion, NMSE decreased from 0.15-0.2 to approximately 0.01 with DDBMC, indicating a substantial reduction in differences from the reference image across various brain regions. In the Structural Similarity Index (SSIM), DDBMC improved it to above 0.96 Contrast assessment revealed notable improvements with DDBMC. In continuous rotational motion, % contrast increased from 42.4% to 73.5%, In tilting motion, % contrast increased from 52.3% to 64.5%, eliminating significant differences from the static reference image. These findings underscore the efficacy of DDBMC in enhancing image contrast and minimizing motion induced variations across different motion scenarios. CONCLUSIONS: DDBMC processing can effectively compensate for continuous rotational and tilting motion of the head during PET, with motion angles of approximately 20 degrees. However, a significant limitation of this study is the exclusive validation of the proposed method using a Hoffman phantom; its applicability to the human brain has not been investigated. Further research involving human subjects is necessary to assess the generalizability and reliability of the presented motion correction technique in real clinical scenarios.
Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis

Shunji Mugikura, Naoko Mori, Miyeong Gang, Shigenori Kanno, Kazutaka Jin, Shin-Ichiro Osawa, Nobukazu Nakasato, Kei Takase

Journal of Clinical Imaging Science　13　38-38　2023/12/22
Publisher: Scientific Scholar
DOI： 10.25259/jcis_77_2023 　

ISSN： 2156-7514

eISSN： 2156-5597

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Objectives: To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides. Material and Methods: Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox. Results: Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions. Conclusion: By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.
Transvenous Radiofrequency Catheter Ablation for an Aldosterone-Producing Tumor of the Left Adrenal Gland: A First in Human Case Report. International-journal

Sota Oguro, Hideki Ota, Satoru Yanagaki, Masahiro Kawabata, Hiroki Kamada, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Hiroaki Toyama, Kouta Tanimoto, Daisuke Konno, Masanori Yamauchi, Yuki Niwa, Hisao Miyamoto, Kenji Mori, Tetsuhiro Tanaka, Hiroshi Ishihata, Kei Takase

Cardiovascular and interventional radiology　46　(12)　1666-1673　2023/12

DOI： 10.1007/s00270-023-03584-x 　

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PURPOSE: To describe a novel technique of transvenous radiofrequency catheter ablation of an aldosterone-producing adenoma (APA) of the left adrenal gland using the GOS System (Japan Lifeline, Tokyo, Japan). Using the GOS system, a flexible radiofrequency tip catheter can be inserted into the adrenal central and tributary veins, the drainers for functional tumors. MATERIALS AND METHODS: An APA at the left adrenal gland, which was diagnosed by segmental adrenal venous sampling following administration of 0.25 mg cosyntropin, was ablated using the GOS catheter inserted into adrenal tributary veins via a right femoral vein 7-Fr sheath. The effect of radiofrequency ablation on APA was assessed using the international consensus on surgical outcomes for unilateral primary aldosteronism (PA). RESULTS: No device-related complications were observed. The patient was deeply sedated under blood pressure and heart rate control with continuous administration of β-blockers. Then, the tumor and surrounding adrenal gland were cauterized at 7000 J two times each in sequence. The output time was 7-11 min for each ablation and 80 min in total. For blood pressure and pulse rate control, esmolol hydrochloride and phentolamine mesylate were used. The contrast enhancement of APA disappeared on dynamic CT immediately after the procedure. PA was biochemically cured until 12 months after the procedure. CONCLUSION: Using the radiofrequency device with the GOS catheter and system is a method for cauterizing adrenal tumors from blood vessels. This approach resulted in a marked reduction in aldosterone concentrations and a complete biochemical cure of PA over the observation period.
A case of percutaneous transhepatic portal vein stenting without using iodinated contrast media for post pancreatectomy portal vein obstruction. International-journal

Hinano Anaba, Sota Oguro, Hideki Ota, Satoru Yanagaki, Tomomi Sato, Kei Nakagawa, Michiaki Unno, Kei Takase

BJR case reports　9　(6)　20220116-20220116　2023/11

DOI： 10.1259/bjrcr.20220116 　

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Postoperative portal vein obstruction could occur as a complication of portal vein reconstruction during hepatic lobectomy or pancreaticoduodenectomy. We report a case of patient with postoperative portal vein obstruction treated with percutaneous transhepatic portal vein stenting without using iodinated contrast media owing to a history of severe allergic reactions. Under ultrasound guidance, carbon dioxide angiography, and appropriate device selection, successful stenting was achieved without serious adverse events. After the operation, portal vein blood flow and clinical symptoms improved, enabling adjuvant chemotherapy. To the best of our knowledge, this is the first case report wherein percutaneous transhepatic portal vein stenting was successfully performed in a patient with an iodine allergy.
「ACSにおける画像診断/Imaging in Acute care surgery」 Hybrid ERでCTに基づいたacute care surgeryを遂行するには放射線部の協力が必要である

谷河篤, 藤田基生, 小野勝範, 勝田賢, 大田英揮, 高瀬圭, 久志本成樹

Japanese Journal of Acute Care Surgery　13　(Suppl.)　95-95　2023/10
Publisher: (一社)日本Acute Care Surgery学会
eISSN： 2436-102X
アキシャル加算平均画像を用いた胸部単純CT検査におけるSize-Specific Dose Estimatesの有用性

田頭豊, 安部圭亮, 小野寺崇, 茅野伸吾, 大田英揮, 高瀬圭

日本放射線技術学会雑誌　79　(9)　1038-1038　2023/09
Publisher: (公社)日本放射線技術学会
ISSN： 0369-4305

eISSN： 1881-4883
Size-Specific Dose Estimatesと撮影長による新たな実効線量換算係数の考案

安部圭亮, 田頭豊, 小野寺崇, 茅野伸吾, 大田英揮, 高瀬圭

日本放射線技術学会雑誌　79　(9)　1102-1102　2023/09
Publisher: (公社)日本放射線技術学会
ISSN： 0369-4305

eISSN： 1881-4883
MRI画像の前立腺癌セグメンテーションにおけるマルチシーケンス画像を用いたDeep Learningの有用性

村上弘晃, 河端真広, 高屋英知, 小林智哉, 大田英揮, 高瀬圭, 植田琢也

日本放射線技術学会雑誌　79　(9)　1075-1075　2023/09
Publisher: (公社)日本放射線技術学会
ISSN： 0369-4305

eISSN： 1881-4883
Role of Magnetic Resonance Imaging in the Screening of Closed Spinal Dysraphism.

Hidekazu Aoki, Shunji Mugikura, Reizo Shirane, Toshiaki Hayashi, Tomomi Kimiwada, Kiyohide Sakai, Keiko Ainoya, Hideki Ota, Kei Takase, Yoshihisa Shimanuki

Neurologia medico-chirurgica　2023/08/30

DOI： 10.2176/jns-nmc.2023-0002 　

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Closed spinal dysraphism (CSD) encompasses a heterogeneous group of spinal cord deformities, which can be accompanied by several types of skin stigmata. These skin stigmata may include inconspicuous features, such as sacral dimples and deformed gluteal clefts, but the association between such mild skin stigmata and CSD is uncertain. This study aimed to reevaluate the indication for magnetic resonance imaging (MRI) in patients with skin stigmata while considering the indication for surgery. A retrospective analysis was conducted on magnetic resonance images of 1255 asymptomatic children with skin stigmata between 2003 and 2015. Skin stigmata classification was based on medical chart data. All subtypes of CSDs except for filum terminale lipomas (FTL), FTL thicker than 2 mm or with low conus medullaris, were considered to meet the surgical indication. CSD prevalence was estimated while considering the surgical indications and assessed after excluding all FTL cases. Skin stigmata were classified into seven types, dimple, deformed gluteal cleft, hair, subcutaneous mass, appendage, discoloration, and protruding bone, and included 1056 isolated and 199 complex ones. The prevalence of CSD was 19.5%, 6.8%, and 0.5% among patients with isolated dimples (n = 881) and 13.9%, 5.8%, and 0.7% among those with isolated deformed gluteal clefts (n = 136) for all cases, surgical indications, and patients without FTL, respectively. Dimples and deformed gluteal clefts had a low prevalence of CSD requiring surgical intervention, and cases without FTL were rare. Asymptomatic patients with mild skin stigmata may not require immediate MRI.
Utility of Carbon Dioxide Venography and Intraprocedural CT for Adrenal Venous Sampling in Patients with an Allergy to Iodinated Contrast Media. International-journal

Hiroki Kamada, Kazumasa Seiji, Sota Oguro, Hideki Ota, Satoru Yanagaki, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

Journal of vascular and interventional radiology : JVIR　2023/07/31

DOI： 10.1016/j.jvir.2023.07.021 　

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PURPOSE: To assess the diagnostic performance of carbon dioxide (CO2) and intraprocedural unenhanced computed tomography (CT) for adrenal venous sampling (AVS) (CO2-intraprocedural unenhanced CT-AVS) in patients with primary aldosteronism (PA) and a history of iodine contrast medium allergy. MATERIALS AND METHODS: CO2-intraprocedural unenhanced CT-AVS was performed in 18 patients with iodine contrast media allergies at the authors' hospital between December 2015 and January 2021. CT and noncontrast magnetic resonance angiography were used to evaluate the preoperative adrenal vein anatomy. CO2 venography was performed to confirm adrenal vein catheterization. Additionally, intraprocedural unenhanced CT was also performed to confirm catheter position in the right adrenal gland. RESULTS: In all cases in which CO2-intraprocedural unenhanced CT-AVS was performed, the right and left adrenal veins were catheterized appropriately, leading to a localized diagnosis. Catheterization of the left adrenal vein was confirmed using CO2 venography in all cases. In 7 of the 18 cases, CO2 venography demonstrated selection of the right adrenal vein. In 15 of 18 cases, intraprocedural unenhanced CT demonstrated selection of the right adrenal vein. CONCLUSIONS: CO2-intraprocedural unenhanced CT-AVS demonstrated the same diagnostic ability for PA localization as conventional AVS with iodine contrast media. The proposed method is clinically feasible for AVS, in which iodine contrast media use is restricted.
Type 2 Endoleak Detection After Endovascular Aneurysm Repair: Can Low-Flow Endoleaks Also Be Visualized in Silicon-Photomultiplier-Based Positron Emission Tomography/Computed Tomography Scans? International-journal

Ayaka Harigai, Yoshitaka Toyama, Michihisa Umetsu, Kentaro Takanami, Kei Takase

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists　15266028231185237-15266028231185237　2023/07/02

DOI： 10.1177/15266028231185237 　

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PURPOSE: To present a novel clinical application of silicon-photomultiplier-based positron emission tomography (SiPM-based PET)/computed tomography (CT), detecting a type II endoleak 5 years after endovascular aneurysm repair (EVAR). TECHNIQUE: SiPM-based PET/CT scans with a standard whole-body protocol were performed for a 73-year-old man with a past medical history of abdominal aortic aneurysms treated with EVAR and currently under investigation of his duodenal papillary carcinoma. The PET/CT demonstrated 18F-fluorodeoxyglucose (FDG) accumulation outside the stent graft in the native sac of the aneurysm. The site of accumulation corresponded to that of the contrast enhancement depicted in the CT angiography taken 1 month earlier. Another CT scan performed 3 months later revealed enlargement of the aneurysm. CONCLUSION: SiPM-based PET/CT, with its superior sensitivity and spatial resolution over conventional PET/CT, can detect type II low-flow endoleaks. CLINICAL IMPACT: Abnormal intra-aneurysmal FDG activity incidentally detected on SiPM-based PET/CT is worthy of attention because it may be indicative of endoleaks. Additional imaging using different modalities should be considered so that the patient would not miss the additional treatment opportunity upon observing sac enlargement. For patients with contraindications for iodine CT contrast media, SiPM-based PET/CT would serve as a suitable alternative.
原発性アルドステロン症診断のpitfall 診断結果はいつまで有効か

手塚雄太, 尾股慧, 小野美澄, 小黒草太, 大田英揮, 高瀬圭, 川崎芳英, 伊藤明宏, 山崎有人, 鈴木貴, 佐藤文俊

日本内分泌学会雑誌　99　(3)　719-719　2023/07
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
Clinical impact of radiation-induced myocardial damage detected by cardiac magnetic resonance imaging and dose-volume histogram parameters of the left ventricle as prognostic factors of cardiac events after chemoradiotherapy for esophageal cancer. International-journal

Rei Umezawa, Hideki Ota, Hidenobu Takagi, Noriyuki Kadoya, Yujiro Nakajima, Noriyoshi Takahashi, Takaya Yamamoto, Kei Takase, Keiichi Jingu

Journal of radiation research　64　(4)　702-710　2023/06/12

DOI： 10.1093/jrr/rrad040 　

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This prospective study aimed to evaluate whether radiation (RT)-induced myocardial damage by cardiac magnetic resonance (CMR) imaging could be a predictor of cardiac events after chemoradiotherapy (CRT) for esophageal cancer and determine the dose-volume histogram (DVH) parameters of the left ventricle (LV) in predicting cardiac events. CMR imaging was performed before and 6 months after CRT in patients receiving definitive CRT. RT-induced myocardial damage was defined as abnormal CMR findings indicating myocardial fibrosis corresponding to an isodose line of ≥30 Gy. The cutoff values of the LV DVH parameters were calculated using the receiver operating characteristic curve based on the presence of RT-induced myocardial damage. The prognostic factors related to cardiac events of Grade 3 or higher were examined. Twenty-three patients were enrolled in the study. RT-induced myocardial damage by late gadolinium enhancement and/or an increase of 100 ms or higher in native T1 post-CRT was detected in 10 of the 23 patients. LV V45 was the best predictive factor for RT-induced myocardial damage with a cutoff value of 2.1% and an area under the curve of 0.75. The median follow-up period was 82.1 months. The 5- and 7-year cumulative incidences of cardiac events of Grade 3 or higher were 14.7 and 22.4%, respectively. RT-induced myocardial damage and LV V45 were significant risk factors (P = 0.015 and P = 0.013, respectively). RT-induced myocardial damage is a significant predictor of cardiac events. LV V45 is associated with RT-induced myocardial damage and subsequent cardiac events.
Erratum to "Carotid computed tomography angiography after cobalt-based alloy carotid artery stenting using ultra-high-resolution computed tomography with model-based iterative reconstruction" [Radiol Case Rep 2021;16:3721-8]. International-journal

Shingo Kayano, Hideki Ota, Yoshimichi Sato, Toshiki Endo, Kuniyasu Niizuma, Ichiro Suzuki, Tsuyoshi Kawamura, Kei Takase

Radiology case reports　18　(6)　2324-2324　2023/06

DOI： 10.1016/j.radcr.2023.03.021 　

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[This corrects the article DOI: 10.1016/j.radcr.2021.09.003.].
Improvement of Imaging Conditions to Improve the Detection Rate of Head and Neck Cancer by Positron Emission Tomography/Computed Tomography Examination. Peer-reviewed

Hayato Odagiri, Kentaro Takanami, Tomohiro Kaneta, Akihito Usui, Ikuho Kojima, Hiroyasu Kodama, Shin Saitou, Yoshitaka Tanaka, Yutaka Dendo, Kei Takase

The Tohoku journal of experimental medicine　260　(2)　141-147　2023/05/30

DOI： 10.1620/tjem.2023.J026 　

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Positron emission tomography (PET)/computed tomography (CT) has improved sensitivity and resolution using silicon photomultiplier as a photosensor. Previously, only a fixed setting was available for the shooting time of 1 bed, but now, the shooting time can be changed for each bed. Time can be shortened or extended depending on the target area. A few studies reported on image reconstruction conditions for head and neck cancer in whole-body PET/CT examinations. Thus, this study aimed to optimize the imaging conditions of the head and neck region during whole-body imaging. A cylindrical acrylic container with a 200 mm diameter was used to simulate the head and neck area using a PET/CT system equipped with a semiconductor detector. Spheres of 6-30 mm in diameter were enclosed in the 200 mm diameter cylindrical acrylic vessel. Radioactivity in 18F solution (Hot:BG ratio 4:1) was enclosed in a phantom following the Japanese Society of Nuclear Medicine (JSNM) guidelines. Background radioactivity concentration was 2.53 kBq/mL. List mode acquisition of 1,800 s was collected at 60-1,800 s with the field of view of 700 mm and 350 mm. The image was reconstructed by resizing the matrix to 128 × 128, 192 × 192, 256 × 256, and 384 × 384, respectively. The imaging time per bed in the head and neck should be at least 180 s, and the reconstruction conditions should be a field of view (FOV) of 350 mm, matrix sizes of ≥ 192, and a Bayesian penalized likelihood (BPL) reconstruction with a β-value of 200. This allows detection of > 70% of the 8-mm spheres in the images.
保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 大田英揮

日本内分泌学会雑誌　99　(1)　317-317　2023/05
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
経静脈的アブレーションによる原発性アルドステロン症の治療 First-in-Human

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 榊原宏幸, 大田英揮

日本内分泌学会雑誌　99　(1)　317-317　2023/05
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 大田英揮

日本内分泌学会雑誌　99　(1)　317-317　2023/05
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
経静脈的アブレーションによる原発性アルドステロン症の治療 First-in-Human

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 榊原宏幸, 大田英揮

日本内分泌学会雑誌　99　(1)　317-317　2023/05
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
無症候性の閉鎖性脊椎癒合不全のスクリーニングにおけるMRIの役割

青木英和, 麦倉俊司, 白根礼造, 林俊哲, 君和田友美, 坂井清英, 相野谷慶子, 大田英揮, 高瀬圭, 島貫義久

日本小児放射線学会雑誌　39　(Suppl.)　35-35　2023/05
Publisher: (一社)日本小児放射線学会
ISSN： 0918-8487

eISSN： 2432-4388
High-flow arteriovenous malformation in the finger with transvenous ethanolamine oleate sclerotherapy using an arterial tourniquet and microballoon occlusion: A case report

Hiromitsu Tannai, Sota Oguro, Munetomo Nagao, Hideki Ota, Kei Takase

Radiology Case Reports　18　(5)　1973-1977　2023/05
Publisher: Elsevier BV
DOI： 10.1016/j.radcr.2023.02.048 　

ISSN： 1930-0433
18 F-FDG PET/CT Imaging Post Heart Transplantation Depicts High Accumulation at Sites of Previous Ventricular Assist Device Insertion. International-journal

Yoshitaka Toyama, Masayuki Otani, Nobuhiro Yaoita, Kentaro Takanami, Kei Takase

Clinical nuclear medicine　48　(4)　366-369　2023/04/01

DOI： 10.1097/RLU.0000000000004580 　

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A 37-year-old man with previous heart transplantation for dilated cardiomyopathy underwent screening for malignancy under posttransplantation immunosuppression. 18 F-FDG PET/CT revealed uptake in 2 peritoneal sites of the pericardium that corresponded to the insertion sites of a left ventricular assist device that was used before transplantation. Additional abnormal uptake in the right axillary artery, aortic arch, and left femoral artery corresponded to the insertion sites for arterial inflow during cardiopulmonary bypass. Knowledge that FDG accumulation may occur at the insertion sites of an extracorporeal-circulation device enables unnecessary tests to be avoided.
胃静脈瘤に対するEthanolamine Oleate Foam B-RTO 当科の治療成績

榊原宏幸, 小黒草太, 柳垣聡, 鎌田裕基, 佐藤友美, 大田英揮, 高瀬圭

Japanese Journal of Radiology　41　(Suppl.)　6-6　2023/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
Shepherd hook形状ハイフロー型マイクロカテーテルの使用経験

小黒草太, 穴場比奈野, 柳垣聡, 鎌田裕基, 樋口慧, 榊原宏幸, 佐藤友美, 影山咲子, 大田英揮, 常陸真, 高瀬圭

Japanese Journal of Radiology　41　(Suppl.)　9-9　2023/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
The Clinical Significance of Preoperative 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Predicting Distant Recurrence in Thymoma

H. Niikawa, T. Watanabe, H. Notsuda, S. Shibata, K. Onodera, Y. Watanabe, T. Hirama, T. Suzuki, H. Oishi, M. Noda, K. Takanami, K. Takase, Y. Okada

Clinical Oncology　35　(2)　e153-e162　2023/02
Publisher: Elsevier BV
DOI： 10.1016/j.clon.2022.10.006 　

ISSN： 0936-6555
Principal component analysis of texture features for grading of meningioma: not effective from the peritumoral area but effective from the tumor area. International-journal

Naoko Mori, Shunji Mugikura, Toshiki Endo, Hidenori Endo, Yo Oguma, Li Li, Akira Ito, Mika Watanabe, Masayuki Kanamori, Teiji Tominaga, Kei Takase

Neuroradiology　65　(2)　257-274　2023/02

DOI： 10.1007/s00234-022-03045-1 　

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PURPOSE: To investigate whether texture features from tumor and peritumoral areas based on sequence combinations can differentiate between low- and non-low-grade meningiomas. METHODS: Consecutive patients diagnosed with meningioma by surgery (77 low-grade and 28 non-low-grade meningiomas) underwent preoperative magnetic resonance imaging including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast-enhanced T1WI (CE-T1WI). Manual segmentation of the tumor area was performed to extract texture features. Segmentation of the peritumoral area was performed for peritumoral high-signal intensity (PHSI) on T2WI. Principal component analysis was performed to fuse the texture features to principal components (PCs), and PCs of each sequence of the tumor and peritumoral areas were compared between low- and non-low-grade meningiomas. Only PCs with statistical significance were used for the model construction using a support vector machine algorithm. k-fold cross-validation with receiver operating characteristic curve analysis was used to evaluate diagnostic performance. RESULTS: Two, one, and three PCs of T1WI, apparent diffusion coefficient (ADC), and CE-T1WI, respectively, for the tumor area, were significantly different between low- and non-low-grade meningiomas, while PCs of T2WI for the tumor area and PCs for the peritumoral area were not. No significant differences were observed in PHSI. Among models of sequence combination, the model with PCs of ADC and CE-T1WI for the tumor area showed the highest area under the curve (0.84). CONCLUSION: The model with PCs of ADC and CE-T1WI for the tumor area showed the highest diagnostic performance for differentiating between low- and non-low-grade meningiomas. Neither PHSI nor PCs in the peritumoral area showed added value.
PlaNet-S: Automatic Semantic Segmentation of Placenta.

Shinnosuke Yamamoto, Isso Saito, Eichi Takaya, Ayaka Harigai, Tomomi Sato, Tomoya Kobayashi, Kei Takase, Takuya Ueda

CoRR　abs/2312.11580　2023

DOI： 10.48550/arXiv.2312.11580 　
Individualized risk assessment of recanalization of visceral aneurysms using stagnation of intra-aneurysmal flow

Hiroki Kamada, Masanori Nakamura, Hideki Ota, Sota Oguro, Satoshi Higuchi, Tomomi Sato, Kei Takase

Journal of Biorheology　37　(2)　73-82　2023
Publisher: Japanese Society of Biorheology
DOI： 10.17106/jbr.37.73 　

ISSN： 1867-0466

eISSN： 1867-0474
Bipolar Radiofrequency Ablation of the Adrenal Gland: In Vivo and Ex Vivo Experiments

Tomo Kinoshita, Kazumasa Seiji, Sota Oguro, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

The Tohoku Journal of Experimental Medicine　259　(2)　127-133　2023
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j110 　

ISSN： 0040-8727

eISSN： 1349-3329
Clinical impact of cardiac magnetic resonance in patients with suspected coronary artery disease associated with chronic kidney disease (AQUAMARINE-CKD study): study protocol for a randomized controlled trial

Teruo Noguchi, Hideki Ota, Naoya Matsumoto, Yoshiaki Morita, Akira Oshita, Eiji Kawasaki, Tomohiro Kawasaki, Kensuke Moriwaki, Shingo Kato, Kazuki Fukui, Tomoya Hoshi, Hiroaki Watabe, Tomoaki Kanaya, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Kensuke Takagi, Shuichi Yoneda, Kenichiro Sawada, Takamasa Iwai, Hideo Matama, Satoshi Honda, Masashi Fujino, Hiroyuki Miura, Kunihiro Nishimura, Kei Takase

Trials　23　(1)　2022/12

DOI： 10.1186/s13063-022-06820-w 　

eISSN： 1745-6215
Blood flow analysis with computational fluid dynamics and 4D-flow MRI for vascular diseases. International-journal

Hiroki Kamada, Masanori Nakamura, Hideki Ota, Satoshi Higuchi, Kei Takase

Journal of cardiology　80　(5)　386-396　2022/11

DOI： 10.1016/j.jjcc.2022.05.007 　

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Both computational fluid dynamics (CFD) and time-resolved, three-dimensional, phase-contrast, magnetic resonance imaging (4D-flow MRI) enable visualization of time-varying blood flow structures and quantification of blood flow in vascular diseases. However, they are totally different. CFD is a method to calculate blood flow by solving the governing equations of fluid mechanics, so the obtained flow field is somewhat virtual. On the other hand, 4D-flow MRI measures blood flow in vivo, thus the flow is real. Recently, with the development and enhancement of computers, medical imaging techniques, and related software, blood flow analysis has become more accessible to clinicians and its usefulness in vascular diseases has been demonstrated. In this review, we have outlined the methods and characteristics of CFD and 4D-flow MRI, respectively. We have discussed the differences in the characteristics between both methods; reviewed the milestones achieved by blood flow analysis in various vascular diseases; and discussed the usefulness, challenges, and limitations of blood flow analysis. We have discussed the difficulties and limitations of current blood flow analysis. We have also discussed our views on future directions.
慢性大動脈解離症例における選択的真腔血管内造影CT検査を用いたAdamkiewicz動脈の同定

大谷将之, 伊藤校輝, 樋口慧, 板垣皓大, 武富龍一, 前田恵, 鈴木佑輔, 鈴木智之, 片平晋太郎, 高橋悟朗, 熊谷紀一郎, 大田英揮, 高瀬圭, 齋木佳克

日本胸部外科学会定期学術集会　75回　CCPA1-6　2022/10
Publisher: (一社)日本胸部外科学会
Usefulness of maximum intensity projection images of non-enhanced CT for detection of hyperdense middle cerebral artery sign in acute thromboembolic ischemic stroke

Sota Oguro, Shunji Mugikura, Hideki Ota, Seiji Bito, Yuta Asami, Wataru Sotome, Yoshiaki Ito, Hideki Kaneko, Kazuyo Suzuki, Nobuya Higuchi, Kei Takase

Japanese Journal of Radiology　40　(10)　1046-1052　2022/10

DOI： 10.1007/s11604-022-01289-8 　

ISSN： 1867-1071

eISSN： 1867-108X
Usefulness of cardiac magnetic resonance for early detection of cancer therapeutics-related cardiac dysfunction in breast cancer patients. International-journal

Yosuke Terui, Koichiro Sugimura, Hideki Ota, Hiroshi Tada, Kotaro Nochioka, Haruka Sato, Yuko Katsuta, Junko Fujiwara, Narumi Harada-Shoji, Akiko Sato-Tadano, Yoshiaki Morita, Wenyu Sun, Satoshi Higuchi, Shunsuke Tatebe, Shigefumi Fukui, Saori Miyamichi-Yamamoto, Hideaki Suzuki, Nobuhiro Yaoita, Nobuhiro Kikuchi, Miku Sakota, Satoshi Miyata, Yasuhiko Sakata, Takanori Ishida, Kei Takase, Satoshi Yasuda, Hiroaki Shimokawa

International journal of cardiology　371　472-479　2022/09/14

DOI： 10.1016/j.ijcard.2022.09.025 　

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BACKGROUND: Prognosis of breast cancer patients has been improved along with the progress in cancer therapies. However, cancer therapeutics-related cardiac dysfunction (CTRCD) has been an emerging issue. For early detection of CTRCD, we examined whether native T1 mapping and global longitudinal strain (GLS) using cardiac magnetic resonance (CMR) and biomarkers analysis are useful. METHODS: We prospectively enrolled 83 consecutive chemotherapy-naïve female patients with breast cancer (mean age, 56 ± 13 yrs.) between 2017 and 2020. CTRCD was defined based on echocardiography as left ventricular ejection fraction (LVEF) below 53% at any follow-up period with LVEF>10% points decrease from baseline after chemotherapy. To evaluate cardiac function, CMR (at baseline and 6 months), 12‑lead ECG, echocardiography, and biomarkers (at baseline and every 3 months) were evaluated. RESULTS: A total of 164 CMRs were performed in 83 patients. LVEF and GLS were significantly decreased after chemotherapy (LVEF, from 71.2 ± 4.4 to 67.6 ± 5.8%; GLS, from -27.9 ± 3.9 to -24.7 ± 3.5%, respectively, both P < 0.01). Native T1 value also significantly elevated after chemotherapy (from 1283 ± 36 to 1308 ± 39 msec, P < 0.01). Among the 83 patients, 7 (8.4%) developed CTRCD. Of note, native T1 value before chemotherapy was significantly higher in patients with CTRCD than in those without it (1352 ± 29 vs. 1278 ± 30 msec, P < 0.01). The multivariable logistic regression analysis revealed that native T1 value was an independent predictive factor for the development of CTRCD [OR 2.33; 95%CI 1.15-4.75, P = 0.02]. CONCLUSIONS: These results indicate that CMR is useful to detect chemotherapy-related myocardial damage and predict for the development of CTRCD in breast cancer patients.
Safety and feasibility of radiofrequency ablation using bipolar electrodes for aldosterone-producing adenoma: a multicentric prospective clinical study. International-journal

Sota Oguro, Ryo Morimoto, Kazumasa Seiji, Hideki Ota, Tomo Kinoshita, Masahiro Kawabata, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Fumitoshi Satoh, Sadayoshi Ito, Nobukazu Moriya, Seishi Matsui, Tetsuo Nishikawa, Masao Omura, Kazuki Nakai, Seishi Nakatsuka, Isao Kurihara, Kazutoshi Miyashita, Wataru Koda, Tetsuya Minami, Yoshiyu Takeda, Mitsuhiro Kometani, Yutaka Oki, Toshihiro Oishi, Takasuke Ushio, Satoshi Goshima, Kei Takase

Scientific reports　12　(1)　14090-14090　2022/08/18

DOI： 10.1038/s41598-022-18136-5 　

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Evaluation of feasibility and safety of percutaneous radiofrequency ablation using bipolar radiofrequency devices in a prospective multicenter cohort of patients with benign aldosterone-producing adenoma. A total of five institutions participated. CT-guided percutaneous RFA was performed for patients diagnosed as APA. The safety of the procedure was evaluated using the Common Terminology Criteria for Adverse Events. During the 84-day follow-up period, serial changes in plasma aldosterone concentration and plasma renin activity were measured. The percentage of patients with normalized hormonal activity after the procedure, was calculated with 95% confidence intervals. Forty patients were enrolled, and two patients were excluded for cerebral hemorrhage and no safe puncture root. In another patients, RFA was tried, but an intraprocedural intercostal arterial injury occurred. Consequently, RFA was completed in thirty-seven patients (20 men, 17 women; mean age, 50.4 ± 10.0 year). The tumor size was 14.8 ± 3.8 mm. The treatment success rate of the ablation was 94.6% (35/37), and a 2nd session was performed in 2.7% (1/37) patients. Grade 4 adverse events were observed in 4 out of 38 sessions (10.5%). The normalization of plasma aldosterone concentration or aldosterone-renin ratio was 86.5% (72.0-94.1: 95% confidence interval) on day 84. Percutaneous CT-guided RFA for APA using a bipolar radiofrequency system was safe and feasible with clinical success rate of 86.5% on day 84.
Transvenous Radiofrequency Ablation of Adrenal Gland: Experimental Study. International-journal

Hiroyuki Sakakibara, Kazumasa Seiji, Sota Oguro, Kenji Mori, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Takuya Masuda, Hisao Miyamoto, Takuya Hirao, Yuki Niwa, Yohei Suzuki, Yasutaka Baba, Fumitoshi Satoh, Kei Takase

Cardiovascular and interventional radiology　45　(8)　1178-1185　2022/08

DOI： 10.1007/s00270-022-03155-6 　

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PURPOSE: The aim was to evaluate a flexible device for transvenous adrenal gland radiofrequency ablation in vitro and in an in vivo animal model. MATERIALS AND METHODS: A flexible radiofrequency-tip catheter with an inner-cooling mechanism and a guidewire lumen was made. Then, using a polyvinyl alcohol gel model, the ablation diameter was evaluated and how much energy to deliver in vivo was determined. Finally, transvenous radiofrequency ablation of the left adrenal glands of two pigs was performed, delivering 5000 or 7000 J in a single dose to each. The ablation effects were also assessed by histological examination of hematoxylin-eosin-stained sections. RESULTS: The mean ablation diameters in the gel model were 20.2 and 21.9 mm in the short axis and 15 and 20 mm in the long axis for 5000 or 7000 J, respectively. The device was inserted into porcine left adrenal vein with no complications. The mean ablation diameters were 10 mm in the shorter axis (whole thickness of porcine left adrenal gland) in the porcine model for 7000 J. Transient increases in blood pressure and heart rate occurred during ablation. Histologically, the adrenal gland showed severe necrosis at ablated area. There was venous congestion upstream in a non-ablated area, and thermal damage to surrounding organs was not observed. CONCLUSIONS: A flexible radiofrequency-tip catheter could be inserted successfully into the left adrenal vein. The left adrenal gland was entirely ablated without any thermal damage to surrounding organs. We suggest transvenous adrenal ablation has potential as a therapeutic option for primary aldosteronism.
【アルドステロンをめぐる臨床課題】原発性アルドステロン症治療におけるラジオ波治療の意義

柳垣聡, 小黒草太, 清治和将, 高瀬圭, 尾股慧, 手塚雄太, 小野美澄, 森本玲, 田中哲洋, 佐藤文俊

糖尿病・内分泌代謝科　55　(2)　204-209　2022/08
Publisher: (有)科学評論社
ISSN： 2435-1946
Multimodal imaging findings including high-resolution 3D T2-weighted imaging for COVID-19 vaccine-associated axillary lymphadenopathy in a patient with breast cancer

Hiroaki Shimizu, Naoko Mori, Hainan Ren, Minoru Miyashita, Satoko Sato, Shunji Mugikura, Kei Takase

Radiology Case Reports　17　(8)　2831-2836　2022/08

DOI： 10.1016/j.radcr.2022.04.044 　

eISSN： 1930-0433
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging

Naoko Mori, Chihiro Inoue, Hajime Tamura, Tatsuo Nagasaka, Hainan Ren, Satoko Sato, Yu Mori, Minoru Miyashita, Shunji Mugikura, Kei Takase

Magnetic Resonance Imaging　90　53-60　2022/07

DOI： 10.1016/j.mri.2022.04.003 　

ISSN： 0730-725X

eISSN： 1873-5894
Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment

Simon Tupin, Kei Takase, Makoto Ohta

Fluids　7　(7)　220-220　2022/06/30
Publisher: MDPI AG
DOI： 10.3390/fluids7070220 　

eISSN： 2311-5521

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Decades after its introduction, endovascular aneurysm repair remains a challenging procedure with risks of collateral patency failure. Here, we investigate the ability of a porous stent, the Multilayer Flow Modulator (MFM), to maintain renal perfusion after a single or overlapping case. Silicone models representing an ideal infrarenal AAA geometry were used to analyze and compare three cases (control, single MFM and two overlapped MFMs). Micro-computed tomography was used to image the deployed MFM devices geometry and evaluate pore size and density along with porosity in both two (planimetric) and three dimensions (gravimetric). Laser particle image velocimetry (PIV) experiments were performed to image velocity and vorticity fields at the aorta-renal bifurcation. Flow experiments revealed renal arteries perfusion preservation in both single and overlapped cases. Microstructure analysis revealed an uneven distribution of wires in the MFM devices leading to local change in planimetric porosity and pore size. Overlap of a second MFM device led to a significant decrease in those 2D metrics but did not affect the gravimetric porosity and the branch perfusion. This first microstructure evaluation of MFM device combined with flow experiments revealed the ability of the device to preserve collateral flow thanks to a highly porous microstructure.
The role of magnetic resonance imaging in prostate cancer patients on active surveillance

Naoko Mori, Shunji Mugikura, Kei Takase

The British Journal of Radiology　96　(1151)　20220140　2022/05/23

DOI： 10.1259/bjr.20220140 　

eISSN： 1748-880X
Update on the roles of imaging in the management of chronic thromboembolic pulmonary hypertension. International-journal

Satoshi Higuchi, Hideki Ota, Nobuhiro Yaoita, Hiroki Kamada, Hidenobu Takagi, Taiju Sato, Satoshi Yasuda, Kei Takase

Journal of cardiology　81　(3)　297-306　2022/04/27

DOI： 10.1016/j.jjcc.2022.03.001 　

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Chronic thromboembolic pulmonary hypertension (CTEPH), classified as group 4 pulmonary hypertension (PH), is caused by stenosis and obstruction of the pulmonary arteries by organized thrombi that are incompletely resolved after acute pulmonary embolism. The prognosis of patients with CTEPH is poor if untreated; however, in expert centers with multidisciplinary teams, a treatment strategy for CTEPH has been established, dramatically improving its prognosis. CTEPH is currently not a fatal disease and is the only curable form of PH. Despite these advances and the establishment of treatment approaches, early diagnosis is still challenging, especially for non-experts, for several reasons. One of the reasons for this is insufficient knowledge of the various diagnostic imaging modalities, which are essential in the clinical practice of CTEPH. Imaging modalities should detect the following pathological findings: lung perfusion defects, thromboembolic lesions in pulmonary arteries, and right ventricular remodeling and dysfunction. Perfusion lung scintigraphy and catheter angiography have long been considered gold standards for the detection of perfusion defects and assessment of vascular lesions, respectively. However, advances in imaging technology of computed tomography and magnetic resonance imaging have enabled the non-invasive detection of these abnormal findings in a single examination. Cardiac magnetic resonance (CMR) is the gold standard for evaluating the morphology and function of the right heart; however, state-of-the-art techniques in CMR allow the assessment of cardiac tissue characterization and hemodynamics in the pulmonary arteries. Comprehensive knowledge of the role of imaging in CTEPH enables appropriate use of imaging modalities and accurate image interpretation, resulting in early diagnosis, determination of treatment strategies, and appropriate evaluation of treatment efficacy. This review summarizes the current roles of imaging in the clinical practice for CTEPH, demonstrating the characteristic findings observed in each modality.
新規測定法によるアルドステロン症診断と高血圧症診療の精緻化

佐藤文俊, 小野美澄, 手塚雄太, 尾股慧, 山崎有人, 森本玲, 高瀬圭, 田中哲洋, 笹野公伸, 小島哲

日本内分泌学会雑誌　98　(1)　214-214　2022/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
原発性アルドステロン症のラジオ波焼灼治療医師主導治験から保険収載までの経験

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 清治和将, 大田英揮, 森本玲

日本内分泌学会雑誌　98　(1)　383-383　2022/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
Clinical Application of 4D Flow MR Imaging to Pulmonary Hypertension.

Hideki Ota, Hiroki Kamada, Satoshi Higuchi, Kei Takase

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　21　(2)　309-318　2022/03/01

DOI： 10.2463/mrms.rev.2021-0111 　

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Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure (PAP). Although right-heart catheterization is the gold standard method for the diagnosis of PH by definition, various less-invasive imaging tests have been used for screening, detection of underlying diseases-causing PH, and monitoring of diseases. Among them, 4D flow MRI is an emerging and unique imaging test that allows for comprehensive visualization of blood flow in the right heart and proximal pulmonary arteries. The characteristic blood flow pattern observed in patients with PH is vortical flow formation in the main pulmonary artery. Recent studies have proposed the use of these findings to determine not only the presence of PH but also estimate the mean PAP. Other applications of 4D flow MRI for PH include measurement of wall shear stress, helicity, and 3D flow balance in the pulmonary arteries. It is worth noting that 4D flow has also the potential for longitudinal follow-ups. In this review, the clinical definition of PH, summary of conventional imaging tests, characteristics of pulmonary arterial flow as shown by 4D flow MRI, and clinical application of 4D flow MRI in the management of patients with PH will be discussed.
Novel technique for recanalization of severe hepaticojejunal obstruction using a transseptal needle in a pediatric liver transplant recipient

Kengo Sasaki, Hideki Ota, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Yoshikatsu Saitoh, Norifumi Kanai, Hiroyasu Nishimaki, Kei Takase, Michiaki Unno, Takashi Kamei

Pediatric Transplantation　26　(2)　2022/03

DOI： 10.1111/petr.14160 　

ISSN： 1397-3142

eISSN： 1399-3046
Quantification of vortex flow in pulmonary arteries of patients with chronic thromboembolic pulmonary hypertension

Hiroki Kamada, Hideki Ota, Masanori Nakamura, Wenyu Sun, Tatsuo Aoki, Haruka Sato, Koichiro Sugimura, Kei Takase

European Journal of Radiology　148　2022/03

DOI： 10.1016/j.ejrad.2021.110142 　

ISSN： 0720-048X

eISSN： 1872-7727
Grading of placental accrete spectrum using texture analysis of magnetic resonance imaging. International-journal

Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

Clinical imaging　85　8-9　2022/02/22

DOI： 10.1016/j.clinimag.2022.02.018 　
未破裂動脈瘤の造影MRI vessel wall imaging stableとunstableの分別に有用な定量的パラメータの分析

森菜緒子, 麦倉俊司, 高瀬圭, 遠藤英徳

Japanese Journal of Radiology　40　(Suppl.)　2-2　2022/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
肺線維症を来たし,肺移植を施行した自己免疫性肺胞蛋白症の1例

冨永循哉, 高瀬圭, 平間崇, 岡田克典, 齊藤涼子

Japanese Journal of Radiology　40　(Suppl.)　2-2　2022/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
関節リウマチ薬物治療効果判定に有効な手関節ダイナミックMRIのパラメータ検証

森菜緒子, 常陸真, 麦倉俊司, 高瀬圭, 森優, 井上麻美

Japanese Journal of Radiology　40　(Suppl.)　5-5　2022/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
Letter to the editor on "High signal intensity on diffusion-weighted magnetic resonance images is a useful finding for detecting early-stage pancreatic cancer". International-journal

Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

Abdominal radiology (New York)　47　(2)　905-906　2022/02

DOI： 10.1007/s00261-021-03346-8 　
Extra- or Peritumoral Hyperintensity on T2-weighted Images in Patients with Breast Cancer. International-journal

Naoko Mori, Shunji Mugikura, Kei Takase

Radiology　302　(2)　E7-E8　2022/02

DOI： 10.1148/radiol.2021210939 　
Longitudinal evaluation of apparent diffusion coefficient values as a predictor of Prostate Cancer Research International Active Surveillance reclassification. International-journal

Eri Ota, Naoko Mori, Shinichi Yamashita, Shunji Mugikura, Akihiro Ito, Kei Takase

Abdominal radiology (New York)　47　(2)　814-826　2022/02

DOI： 10.1007/s00261-021-03372-6 　

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PURPOSE: This study aimed to evaluate the effectiveness of apparent diffusion coefficient (ADC) parameters in distinguishing between Prostate Cancer Research International Active Surveillance (PRIAS) non-reclassification and reclassification groups during active surveillance (AS) of prostate cancer. METHODS: We included 55 patients who fulfilled the PRIAS criteria and underwent ≥ 2 magnetic resonance imaging (MRI) including diffusion-weighted imaging with an interval of ≤ 3 years between baseline and second MRI. A mono-exponential fitting model was used to automatically create ADC maps with minimum b-values of 0 and maximum of 2000 s/mm2. For detectable lesions on ADC maps, the lesions were manually segmented on each slice of the ADC maps. For undetectable lesions, the corresponding normal-appearing zone of the lobe on each slice of ADC maps was segmented. The ADC data for each slice were summed to obtain the 25th, 50th, and 75th percentile ADC values of the histogram at baseline and second MRI. These ADC parameters at baseline and second MRI, and the changes of ADC parameters from baseline to second MRI were compared between PRIAS non-reclassification and reclassification groups. RESULTS: The PRIAS reclassification group had significantly lower 25th, 50th, and 75th percentile ADC values at second MRI compared to the non-reclassification group. The non-reclassification group had significantly lower changes in ADC values in these percentiles compared to the reclassification group. CONCLUSION: The ADC parameters at second MRI and the changes from baseline to second MRI may be effective distinguishing factors between PRIAS non-reclassification and reclassification groups.
Application of cumulative summation (CUSUM) method and mathematical model to evaluate the learning effect in central venous catheter port implantation.

Naoko Mori, Hiroaki Shimizu, Shunji Mugikura, Kei Takase

Japanese journal of radiology　2022/01/22

DOI： 10.1007/s11604-021-01242-1 　
Quantitative assessment of microstructural evolution of intracranial aneurysm wall by vessel wall imaging. International-journal

Hidenori Endo, Naoko Mori, Shunji Mugikura, Kuniyasu Niizuma, Shunsuke Omodaka, Kei Takase, Teiji Tominaga

Neuroradiology　64　(7)　1343-1350　2022/01/08

DOI： 10.1007/s00234-021-02877-7 　

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PURPOSE: This study aimed to evaluate new quantitative parameters of aneurysm wall enhancement (AWE) on magnetic resonance vessel wall imaging (VWI) in differentiating between the stable and evolving unruptured intracranial aneurysms (UIAs). METHODS: Thirty-eight consecutive patients with UIAs (27 stable and 11 evolving) underwent VWI with contrast-enhanced 3D T1 volume isotropic turbo spin echo acquisition. The voxel-based enhancement maps were created using pre- and post-contrast images. The aneurysmal lumen with signal suppression by black-blood method was segmented. Then, one voxel outer and inner layers of the lumen contour were automatically segmented. The shape features of the aneurysms and AWE of the two layers were compared between stable and evolving groups. RESULTS: The shape features, including aneurysm volume, surface, and compacity were significantly different between the stable and evolving groups (P = 0.024, 0.028, and 0.033, respectively). Stable and evolving groups also differed significantly in the AWE at the union of outer and inner layers of the aneurysm wall (P = 0.0082) but not in that of the outer or inner layer alone. Multivariate logistic regression analysis revealed significant differences in aneurysm volume, surface, and AWE at the union of outer and inner layers between the two groups (P = 0.0029, 0.0092, and 0.0033, respectively). Receiver operating characteristics curve analysis revealed that the area under the curve of the logistic regression model was 0.89. CONCLUSION: Quantitative combined analysis of aneurysm shape features and AWE of the union of outer and inner layers were effective for differentiating between stable and evolving UIAs.
Post-ISCHEMIA Trial Era: Reconsideration of the Role of Nuclear Cardiology in Patients with Chronic Coronary Artery Disease.

Keisuke Kiso, Atsuro Masuda, Kentaro Takanami, Tomohiro Kaneta, Kei Takase

Annals of nuclear cardiology　8　(1)　86-90　2022

DOI： 10.17996/anc.22-00168 　

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The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial has had a great impact on the management of chronic coronary artery disease (CAD). One of the implications of this trial is the importance of close patient follow-up. To improve patient prognosis, evaluation of the residual extent of ischemia after treatment may be important because several studies have shown a close relationship between residual ischemia and cardiac events. For this assessment, myocardial perfusion single-photon emission computed tomography (MPS) has been utilized and is almost the only modality. Among the participants in the ISCHEMIA trial, more than 10% were excluded due to the absence of obstructive CAD. The pathophysiology of ischemia without non-obstructive coronary artery disease (INOCA) is gaining recognition; however, diagnosis is difficult, except for the assessment of myocardial flow reserve (MFR). Myocardial perfusion positron emission tomography (PET) is the most common modality for noninvasive evaluation of MFR; however, its availability in Japan is limited. For a breakthrough in this situation, a novel gamma camera with a cadmium zinc telluride (CZT) semiconductor might be one of the solutions that enables the evaluation of MFR with a commercially available perfusion tracer, similar to PET. Another solution is a novel PET tracer with a longer half-life. Clinical trials with 18F labeled perfusion agents have been initiated in Japan, and in a few years, delivery of this perfusion tracer will result in more frequent and easier assessment of MFR.
Prediction of the development of delirium after transcatheter aortic valve implantation using preoperative brain perfusion SPECT. International-journal

Masashi Takeuchi, Hideaki Suzuki, Yasuharu Matsumoto, Yoku Kikuchi, Kentaro Takanami, Toshihiro Wagatsuma, Jun Sugisawa, Satoshi Tsuchiya, Kensuke Nishimiya, Kiyotaka Hao, Shigeo Godo, Tomohiko Shindo, Takashi Shiroto, Jun Takahashi, Kiichiro Kumagai, Masahiro Kohzuki, Kei Takase, Yoshikatsu Saiki, Satoshi Yasuda, Hiroaki Shimokawa

PloS one　17　(11)　e0276447　2022

DOI： 10.1371/journal.pone.0276447 　

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OBJECTIVES: Delirium is an important prognostic factor in postoperative patients undergoing cardiovascular surgery and intervention, including transcatheter aortic valve implantation (TAVI). However, delirium after transcatheter aortic valve implantation (DAT) is difficult to predict and its pathophysiology is still unclear. We aimed to investigate whether preoperative cerebral blood flow (CBF) is associated with DAT and, if so, whether CBF measurement is useful for predicting DAT. METHODS: We evaluated CBF in 50 consecutive patients before TAVI (84.7±4.5 yrs., 36 females) using 99mTc ethyl cysteinate dimer single-photon emission computed tomography. Preoperative CBF of the DAT group (N = 12) was compared with that of the non-DAT group (N = 38) using whole brain voxel-wise analysis with SPM12 and region of interest-based analysis with the easy-Z score imaging system. Multivariable logistic regression analysis with the presence of DAT was used to create its prediction model. RESULTS: The whole brain analysis showed that preoperative CBF in the insula was lower in the DAT than in the non-DAT group (P<0.05, family-wise error correction). Decrease extent ratio in the insula of the DAT group (17.6±11.5%) was also greater relative to that of the non-DAT group (7.0±11.3%) in the region of interest-based analysis (P = 0.007). A model that included preoperative CBF in the insula and conventional indicators (frailty index, short physical performance battery and mini-mental state examination) showed the best predictive power for DAT (AUC 0.882). CONCLUSIONS: These results suggest that preoperative CBF in the insula is associated with DAT and may be useful for its prediction.
Systemic-pulmonary collateral supply associated with clinical severity of chronic thromboembolic pulmonary hypertension: a study using intra-aortic computed tomography angiography

Wenyu Sun, Hideki Ota, Haruka Sato, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Koichiro Sugimura, Junya Tominaga, Hiroaki Shimokawa, Takuya Ueda, Kei Takase

European Radiology　32　(11)　7668-7679　2022

DOI： 10.1007/s00330-022-08768-6 　

ISSN： 0938-7994

eISSN： 1432-1084
Significance of systolic-phase imaging on full-phase ECG-gated CT angiography to detect intimal tears in aortic dissection

Satoru Yanagaki, Atsuro Masuda, Hideki Ota, Masatoshi Kojima, Takashi Hattori, Wahei Mihara, Kei Takase, Takuya Ueda

Heart and Vessels　37　(11)　1947-1956　2022

DOI： 10.1007/s00380-022-02093-0 　

ISSN： 0910-8327

eISSN： 1615-2573
Clinical assessment of efficacy of poly-L-lactide sternal pin on sternal stability and post-operative pain: a prospective randomized trial in cardiovascular surgery. International-journal

Shingo Takahara, Konosuke Sasaki, Takeshi Saito, Kei Sakuma, Hidenori Fujiwara, Ichiro Yoshioka, Kiichiro Kumagai, Wenyu Sun, Kei Takase, Yoshikatsu Saiki

Journal of thoracic disease　14　(1)　76-89　2022/01

DOI： 10.21037/jtd-21-1340 　

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BACKGROUND: Although the incident rate is low, sternal dislocation and dehiscence due to unstable sternal fixation after cardiovascular surgery could cause potentially lethal complications. Thus, to enforce the stability of closed sternum, the sternal pins have been utilized at surgeon's discretion. However, there is no randomized clinical trial to test whether these pins are effective to stabilize a sternum. Hence, this study aimed to examine the clinical efficacy of bioabsorbable poly-L-lactide (PLLA) sternal pins in reinforcing sternal stability and preventing instability of the sternum after full sternotomy. METHODS: We conducted a single institutional, prospective, randomized, single-blinded clinical study involving 100 patients who underwent an initial cardiovascular surgery via sternotomy. Patients were randomly allocated into two groups: with (group P) and without (group N) PLLA sternal pins, at 1:1 ratio from November 2013 to April 2016. Sternal deviation and stability were assessed with postoperative computed tomography (CT) at two postures to put shear stress on the sternum. Additionally, information on patient demographic indices was obtained prospectively, and patient's pain intensity was assessed with numerical rating scoring system during rehabilitation. Furthermore, propensity score matching was performed for further comparative sub-analysis. RESULTS: Ninety-one patients (43 in group P and 48 in group N) were analyzed using the intention-to-treat method. Group N had a significantly higher proportion of males (P=0.015) and ischemic disease as a primary diagnosis (P=0.040) than group P. Postoperative CT showed that the degree of sternal deviation and stability were comparable between the groups. Similarly, the numerical rating score of pain during rehabilitation showed no difference between the groups. Even after adjusting for patient characteristics using propensity score matching method, no significant differences in sternal gaps, stability, and numerical rating score of pain were observed. Of note, no material-related adverse event such as wound infection was found. CONCLUSIONS: We could not identify the efficacy of the sternal pin in enforcing sternal stability based on CT measurements with mild shear stress on sternum after cardiovascular surgery. Nevertheless, our results with no adverse events might encourage further investigations with a more specific cohort who is susceptible to infection but requires an additional sternal fixation. TRIAL REGISTRATION: This study was registered in University Hospital Medical Information Network Clinical Trial Registry (UMIN000017357).
Reversible increase in stress-associated neurobiological activity in the acute phase of Takotsubo syndrome; a brain 18F-FDG-PET study. International-journal

Hideaki Suzuki, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa, Satoshi Yasuda

International journal of cardiology　344　31-33　2021/12/01

DOI： 10.1016/j.ijcard.2021.09.057 　

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INTRODUCTION: Takotsubo syndrome (TTS) is triggered mostly by physical and/or emotional stress that is processed in stress-associated brain regions, including the amygdala. However, it remains unclear whether such stress-induced brain activity is associated with TTS onset. METHODS AND RESULTS: We acquired brain [18F]-2-fluoro-deoxy-d-glucose (18F-FDG) positron emission tomography in 4 TTS patients (44-82 yrs., 3 women) on days 2-4 (acute phase) and days 29-40 (recovery phase) after diagnosis of TTS was made by coronary angiography and left ventriculogram. The 18F-FDG uptake was measured globally and also in the pre-defined regions of interest of the bilateral amygdala on the common Montreal Neurological Institute space; all 18F-FDG images were normalized using automated image pre-processing. Amygdalar activity was calculated by dividing the 18F-FDG uptake of the amygdala by the global brain uptake. Left ventriculograms showed that apical ballooning was typical at diagnosis and was then relieved in the recovery phase. Amygdalar activity in the acute phase (0.872 ± 0.032) was higher than in the recovery phase (0.805 ± 0.037) (P = 0.013). CONCLUSIONS: We report here 4 cases of TTS showing higher amygdalar activity in the acute phase as compared with the recovery phase, suggesting that increased stress-induced neurobiological activity is associated with TTS onset.
Fibromuscular dysplasia with recurrence after “long-term” following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients

Shuntaro Oribe, Takafumi Toyohara, Eikan Mishima, Takehiro Suzuki, Koichi Kikuchi, Shun Watanabe, Yoshiaki Morita, Hideki Ota, Kazumasa Seiji, Mariko Miyazaki, Kei Takase, Takaaki Abe

BMC Nephrology　22　(1)　2021/12

DOI： 10.1186/s12882-021-02342-w 　

eISSN： 1471-2369
Carotid computed tomography angiography after cobalt-based alloy carotid artery stenting using ultra-high-resolution computed tomography with model-based iterative reconstruction

Shingo Kayano, Hideki Ota, Yoshimichi Sato, Toshiki Endo, Kuniyasu Niizuma, Ichiro Suzuki, Tsuyoshi Kawamura, Kei Takase

Radiology Case Reports　16　(12)　3721-3728　2021/12

DOI： 10.1016/j.radcr.2021.09.003 　

eISSN： 1930-0433
未破裂脳動脈瘤におけるVessel wall imagingの新規定量評価法

遠藤英徳, 森菜緒子, 麦倉俊司, 新妻邦泰, 面高俊介, 高瀬圭, 冨永悌二

脳血管内治療　6　(Suppl.)　S39-S39　2021/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Importance of ADC parameters from histogram analysis corresponding to histological components in endometrial cancer. International-journal

Naoko Mori, Shunji Mugikura, Kei Takase

European journal of radiology　144　110004-110004　2021/11

DOI： 10.1016/j.ejrad.2021.110004 　
Prediction of placenta accreta spectrum using texture analysis on coronal and sagittal T2-weighted imaging. International-journal

Hainan Ren, Naoko Mori, Shunji Mugikura, Hiroaki Shimizu, Sakiko Kageyama, Masatoshi Saito, Kei Takase

Abdominal radiology (New York)　46　(11)　5344-5352　2021/11

DOI： 10.1007/s00261-021-03226-1 　

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PURPOSE: To separately perform visual and texture analyses of the axial, coronal, and sagittal planes of T2-weighted images and identify the optimal method for differentiating between the normal placenta and placenta accreta spectrum (PAS). METHODS: Eighty consecutive patients (normal group, n = 50; PAS group, n = 30) underwent preoperative MRI. A scoring system (0-2) was used to evaluate the degree of abnormality observed in visual analysis (bulging, abnormal vascularity, T2 dark band, placental heterogeneity). The axial, coronal, and sagittal planes were manually segmented separately to obtain texture features, and seven combinations were obtained: axial; coronal; sagittal; axial and coronal; axial and sagittal; coronal and sagittal; and axial, coronal, and sagittal. Feature selection using the least absolute shrinkage and selection operator method and model construction using a support vector machine algorithm with k-fold cross-validation were performed. AUC was used to evaluate diagnostic performance. RESULTS: The AUC of visual analysis was 0.75. The model 'coronal and sagittal' had the highest AUC (0.98) amongst the seven combinations. The fivefold cross-validation for the model 'coronal and sagittal' showed AUCs of 0.85 and 0.97 in training and validation sets, respectively. The AUC of the model 'coronal and sagittal' for all subjects was significantly higher than that of visual analysis (0.98 vs. 0.75; p < 0.0001). CONCLUSION: The model 'coronal and sagittal' can accurately differentiate between the normal placenta and PAS, with a significantly better diagnostic performance than visual analysis. Texture analysis is an optimal method for differentiating between the normal placenta and PAS.
観測者モデルによる心臓サルコイドーシスPET画像診断能の評価

直井純一郎, 高浪健太郎, 志田原美保, 酒井大輔, 小田桐逸人, 高瀬圭

核医学　58　(Suppl.)　S200-S200　2021/10
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
アルドステロン産生腺腫における18-oxocortisol産生機序の解明

手塚雄太, 山崎有人, 尾股慧, 小野美澄, 森本玲, 高瀬圭, 川崎芳英, 伊藤明宏, 西川潤, 朝井典子, Gomez-Sanchez Celso E., 伊藤貞嘉, 出澤真里, 笹野公伸, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　43回　219-219　2021/10
Publisher: (NPO)日本高血圧学会
片側性原発性アルドステロン症の発症経過を捉え得た若年性高血圧症の一例

手塚雄太, 小野美澄, 山崎有人, 樋口慧, 尾股慧, 森本玲, 大田英揮, 川崎芳英, 高瀬圭, 伊藤明宏, 笹野公伸, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　43回　281-281　2021/10
Publisher: (NPO)日本高血圧学会
Indication of perfusion contrast-enhanced ultrasound for diagnosing lymph nodes.

Naoko Mori, Shunji Mugikura, Kei Takase

Japanese journal of radiology　39　(10)　1017-1018　2021/10

DOI： 10.1007/s11604-021-01160-2 　
Utility of histogram analysis for apparent diffusion coefficient values in evaluating the pathological characteristics of endometrial cancer. International-journal

Naoko Mori, Shunji Mugikura, Kei Takase

The British journal of radiology　20210928-20210928　2021/09/14

DOI： 10.1259/bjr.20210928 　
Cholangiojejunostomy assisted by techniques of interventional radiology for a patient with recurrent jaundice after Kasai portoenterostomy

Ryuji Okubo, Hideyuki Sasaki, Hideki Ota, Motoshi Wada, Taichi Fukuzawa, Hironori Kudo, Ryo Ando, Yuki Endo, Masatoshi Hashimoto, Kosuke Sato, Kei Takase, Masaki Nio

Journal of Pediatric Surgery Case Reports　72　2021/09

DOI： 10.1016/j.epsc.2021.101961 　

eISSN： 2213-5766
Pancreatic foregut cystic malformation with a bifid pancreatic tail

Yuki Endo, Motoshi Wada, Hideyuki Sasaki, Taichi Fukuzawa, Hironori Kudo, Ryo Ando, Satoshi Yamaki, Ryuji Okubo, Masatoshi Hashimoto, Yudai Nakajima, Kosuke Sato, Hidekazu Aoki, Hideki Ota, Kei Takase, Masaki Nio

Journal of Pediatric Surgery Case Reports　72　101963-101963　2021/09
Publisher: Elsevier BV
DOI： 10.1016/j.epsc.2021.101963 　

ISSN： 2213-5766
Experimental Analysis of Pressure and Flow Alterations During and After Insertion of a Multilayer Flow Modulator into an AAA Model with Incorporated Branch. International-journal

Simon Tupin, Kei Takase, Makoto Ohta

Cardiovascular and interventional radiology　44　(8)　1251-1259　2021/08

DOI： 10.1007/s00270-021-02835-z 　

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PURPOSE: The multilayer flow modulator (MFM) device has been used for the treatment of abdominal aortic aneurysm (AAA) for over a decade. Although several clinical studies have been published, criticism and concern over the device efficacy remain, as no quantitative analysis that describes its mechanism has been performed yet. The aim of this study was to experimentally evaluate the effect of MFM device deployment on aneurysmal pressure and branch perfusion. MATERIALS AND METHODS: An experimental flow and pressure monitoring system was developed to analyze the MFM deployment procedure performed by a qualified radiologist in AAA geometries with and without side branch. Particle image velocimetry experiments were then conducted on models with and without MFM device to evaluate and compare flow patterns and local flow velocity and vorticity in the aneurysm. RESULTS: The experiments revealed no significant change in pressure and flow rate during and after deployment of the MFM device. The flow rate of the incorporated branch was fully preserved. On both models, the aneurysmal flow velocity was significantly reduced. In addition, the device modified local flow patterns, reducing vorticity and better feeding the incorporated branch. CONCLUSION: This experimental study provides the basis for a better understanding of the mechanism of the MFM device, which allows intra-aneurysmal flow to decrease while preserving incorporated branch flow and reducing the risk of type II endoleak. The experimental system developed for this study was effective in simulating an endovascular procedure and studying the safety and effectiveness of endovascular devices.
Mathematical model for histogram analysis of dynamic contrast-enhanced MRI: A method to evaluate the drug treatment response in rheumatoid arthritis

Yu Mori, Naoko Mori, Takuya Izumiyama, Asami Inoue, Kei Takase, Toshimi Aizawa

European Journal of Radiology　141　109831-109831　2021/08
Publisher: Elsevier BV
DOI： 10.1016/j.ejrad.2021.109831 　

ISSN： 0720-048X
Efficacy of cell proliferation imaging with 4DST PET/CT for predicting the prognosis of patients with esophageal cancer: a comparison study with FDG PET/CT

Masatoshi Hotta, Ryogo Minamimoto, Jun Toyohara, Kyoko Nohara, Kazuhiko Nakajima, Kei Takase, Kazuhiko Yamada

European Journal of Nuclear Medicine and Molecular Imaging　48　(8)　2615-2623　2021/07
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00259-020-05179-x 　

ISSN： 1619-7070

eISSN： 1619-7089
Assessment of the sequential time–signal enhancement curve of dynamic contrast-enhanced MRI might be effective in diagnosing growth hormone-producing pituitary adenomas

Naoko Mori, Shunji Mugikura, Kei Takase

Japanese Journal of Radiology　2021/06/04
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11604-021-01146-0 　

ISSN： 1867-1071

eISSN： 1867-108X
葛西手術後長期経過後の肝門部再閉塞に対してIVRが有用であった1例

田中拡, 大田英揮, 佐々木英之, 佐野信行, 北見昌広, 齋藤美穂子, 和田基, 福澤太一, 中村恵美, 工藤博典, 安藤亮, 山木聡史, 大久保龍二, 高瀬圭, 仁尾正記

日本小児外科学会雑誌　57　(4)　791-791　2021/06
Publisher: (一社)日本小児外科学会
ISSN： 0288-609X

eISSN： 2187-4247
Ultrashort echo time time-spatial labeling inversion pulse magnetic resonance angiography with denoising deep learning reconstruction for the assessment of abdominal visceral arteries

Ryuichi Mori, Yoshimori Kassai, Atsuro Masuda, Yoshiaki Morita, Tomoyoshi Kimura, Tatsuo Nagasaka, Takashi Nishina, Sho Tanaka, Mitsue Miyazaki, Kei Takase, Hideki Ota

Journal of Magnetic Resonance Imaging　53　(6)　1926-1937　2021/06

DOI： 10.1002/jmri.27481 　

ISSN： 1053-1807

eISSN： 1522-2586
【皮膚悪性腫瘍(第2版)上-基礎と臨床の最新研究動向-】メラノーマメラノーマの検査・診断画像診断 CT、MRI

木下知, 森下陽平, 高瀬圭

日本臨床　79　(増刊2 皮膚悪性腫瘍(上))　225-228　2021/05
Publisher: (株)日本臨床社
ISSN： 0047-1852
Discriminating low-grade ductal carcinoma in situ (DCIS) from non-low-grade DCIS or DCIS upgraded to invasive carcinoma: effective texture features on ultrafast dynamic contrast-enhanced magnetic resonance imaging

Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yo Oguma, Minami Hirasawa, Satoko Sato, Kei Takase

Breast Cancer　2021/04/26
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12282-021-01257-6 　

ISSN： 1340-6868

eISSN： 1880-4233
Beneficial effects of exercise training on physical performance in patients with vasospastic angina. International-journal

Jun Sugisawa, Yasuharu Matsumoto, Masashi Takeuchi, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Ohura, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

International journal of cardiology　328　14-21　2021/04/01

DOI： 10.1016/j.ijcard.2020.12.003 　

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AIMS: In vasospastic angina (VSA), coronary vasomotion abnormalities could develop not only in epicardial coronary arteries but also in coronary microvessels, where calcium channel blockers (CCBs) have limited efficacy. However, efficacy of exercise training for VSA remains to be elucidated. We thus aimed to examine whether vasodilator capacity of coronary microvessels is impaired in VSA patients, and if so, whether exercise exerts beneficial effects on the top of CCBs. METHODS: We performed 2 clinical protocols. In the protocol 1, we measured myocardial blood flow (MBF) using adenosine-stress dynamic computed tomography perfusion (CTP) in 38 consecutive VSA patients and 17 non-VSA controls. In the protocol 2, we conducted randomized controlled trial, where 20 VSA patients were randomly assigned to either 3-month exercise training group (Exercise group) or Non-Exercise group (n= 10 each). RESULTS: In the protocol 1, MBF on CTP was significantly decreased in the VSA group compared with the Non-VSA group (138 ± 6 vs 166 ± 10 ml/100 g/min, P = 0.02). In the protocol 2, exercise capacity was significantly increased in the Exercise group than in the Non-Exercise group (11.5 ± 0.5 to 15.4 ± 1.8 vs 12.6 ± 0.7 to 14.0 ± 0.8 ml/min/kg, P < 0.01). MBF was also significantly improved after 3 months only in the Exercise group (Exercise group, 145 ± 12 to 172 ± 8 ml/100 g/min, P < 0.04; Non-Exercise group, 143 ± 14 to 167 ± 8 ml/100 g/min, P = 0.11), although there were no significant between-group differences. CONCLUSIONS: These results provide the first evidence that, in VSA patients, exercise training on the top of CCBs treatment may be useful to improve physical performance, although its effect on MBF may be minimal.
Value of ultrafast and standard dynamic contrast-enhanced magnetic resonance imaging in the evaluation of the presence and extension of residual disease after neoadjuvant chemotherapy in breast cancer

Erina Kato, Naoko Mori, Shunji Mugikura, Satoko Sato, Takanori Ishida, Kei Takase

Japanese Journal of Radiology　2021/03/20
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11604-021-01110-y 　

ISSN： 1867-1071

eISSN： 1867-108X
乳癌患者における化学療法関連心機能障害の予測におけるNative T1 Mappingの有用性(Usefulness of Native T1 Mapping for Prediction of Chemotherapeutics-related Cardiac Dysfunction in Breast Cancer Patients)

照井洋輔, 杉村宏一郎, 大田英揮, 多田寛, 勝田祐子, 佐藤遥, 後岡広太郎, 建部俊介, 宮田敏, 坂田泰彦, 石田孝宜, 高瀬圭, 安田聡

日本循環器学会学術集会抄録集　85回　OJ29-5　2021/03
Publisher: (一社)日本循環器学会
Usefulness of Native T1 Mapping for Prediction of Chemotherapeutics-related Cardiac Dysfunction in Breast Cancer Patients(和訳中)

照井洋輔, 杉村宏一郎, 大田英揮, 多田寛, 勝田祐子, 佐藤遥, 後岡広太郎, 建部俊介, 宮田敏, 坂田泰彦, 石田孝宜, 高瀬圭, 安田聡

日本循環器学会学術集会抄録集　85回　OJ29-5　2021/03
Publisher: (一社)日本循環器学会
Correction to: Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. International-journal

Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase

European radiology　31　(3)　1780-1781　2021/03

DOI： 10.1007/s00330-020-07144-6 　
The Potential of Computed Tomography Volumetry for the Surgical Treatment in Bilateral Macronodular Adrenal Hyperplasia: A Case Report.

Hiromu Matsunaga, Yuta Tezuka, Tomo Kinoshita, Hiroko Ogata, Yuto Yamazaki, Beata Shiratori, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Akihiro Ito, Hironobu Sasano, Hideo Harigae, Fumitoshi Satoh

The Tohoku journal of experimental medicine　253　(2)　143-150　2021/02

DOI： 10.1620/tjem.253.143 　

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Although adrenal resection is a major option to control hypercortisolemia in patients with bilateral macronodular adrenal hyperplasia, a predictive method for postoperative cortisol production has not been established. A 53-year-old man with ulcerative colitis was referred to our hospital for bilateral multiple adrenal nodules and hypertension. Physical and endocrinological examination revealed inappropriate cortisol production and suppressed secretion of adrenocorticotropic hormone with no typical signs of Cushing's syndrome. Imaging analysis revealed bilateral adrenal nodular enlargement, the nodules of which had the radiological features of adrenocortical adenomas without inter-nodular heterogeneity. In addition, computed tomography volumetry demonstrated that the left adrenal gland (70 mL) accounts for three quarters of the total adrenal volume (93 mL). The patient was diagnosed as subclinical Cushing's syndrome due to bilateral macronodular adrenal hyperplasia, and subsequently underwent a left laparoscopic adrenalectomy with the estimation of 75% decrease in the cortisol level based on the adrenal volume. The surgical treatment ultimately resulted in control of the cortisol level within the normal range, which was compatible to our preoperative prediction. However, regardless of the sufficient cortisol level, ulcerative colitis was exacerbated after the surgery, which needed a systemic therapy for remission. This case indicates successful surgical control of hypercortisolemia based on computed tomography volumetry in bilateral macronodular adrenal hyperplasia, as well as the perioperative exacerbation risk for inflammatory diseases in Cushing's syndrome. We report the potential utility of computed tomography volumetry as a quantitative method with retrospective evaluation of our historical cases.
Treatment of Refractory Hypertension with Timely Angioplasty in Total Renal Artery Occlusion with Atrophic Kidney.

Yuri Sasaki, Eikan Mishima, Koichi Kikuchi, Takafumi Toyohara, Takehiro Suzuki, Hideki Ota, Kazumasa Seiji, Mariko Miyazaki, Hideo Harigae, Sadayoshi Ito, Kei Takase, Takaaki Abe

Internal medicine (Tokyo, Japan)　60　(2)　287-292　2021/01/15

DOI： 10.2169/internalmedicine.5290-20 　

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Angioplasty for cases of chronic total occlusion of renal artery with/without atrophic kidney is generally not recommended. We herein report a 57-year-old man who presented with renin-mediated refractory hypertension caused by occlusion of a unilateral renal artery leading to kidney atrophy (length: 69 mm). Angioplasty favorably achieved blood pressure control with normalized renin secretion and enlargement of the atrophic kidney to 85 mm. Timely angioplasty can be beneficial in select patients, even with an atrophic kidney and total occlusion, especially in cases with deterioration of hypertension within six months and the presence of collateral perfusion to the affected kidney.
Abnormal Findings on "T1WI or DWI or MRCP:" An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group. International-journal

Hainan Ren, Naoko Mori, Minami Hirasawa, Shin Hamada, Shunji Mugikura, Atsushi Masamune, Kei Takase

Journal of clinical imaging science　11　54-54　2021

DOI： 10.25259/JCIS_158_2021 　

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Objectives: The objectives of the study was to evaluate the diagnostic performance of findings on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and magnetic resonance cholangiopancreatography (MRCP) separately and to identify an optimal Boolean interpretation model for discriminating patients with small pancreatic ductal adenocarcinoma (PDAC) from control groups in clinical practice. Material and Methods: We retrospectively enrolled 30 patients with surgery confirmed small PDAC (≤20 mm) and 302 patients without pancreatic abnormality between April 2008 and February 2020. The presence of masses was evaluated by T1WI, T2WI, and DWI. Abnormality of the main pancreatic duct (MPD) was evaluated by T2WI and MRCP. Multivariate logistic regression analysis was performed to select significant sequences for discriminating the small PDAC and control groups. Boolean operators "OR" or "AND" were used to construct sequence combinations. Diagnostic performances of these sequences and combinations were evaluated by X 2 tests. Results: The sensitivity of T2WI was lowest (20%) for detecting masses. For evaluating MPD abnormality, sensitivity was higher for MRCP than for T2WI (86.7% vs. 53.3%). Multivariate logistic regression analysis showed that T1WI and DWI for detecting the presence of masses and MRCP for evaluating MPD abnormality were significantly associated with differentiation between the two groups (P = 0.0002, P = 0.0484, and P < 0.0001, respectively). Seven combinations were constructed with T1WI, DWI, and MRCP. The combination of findings on "T1WI or DWI or MRCP" achieved the highest sensitivity of 96.7% and negative predictive value of 99.6%. Conclusion: The combination of findings on "T1WI or DWI or MRCP" might be an optimal interpretation model for discriminating small PDAC from control groups in clinical practice.
Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. International-journal

Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase

European radiology　31　(1)　55-64　2021/01

DOI： 10.1007/s00330-020-07047-6 　

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OBJECTIVES: The purpose of our study was to perform Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma, and to evaluate the relationship between histological grade and the ratios of the different clusters in each patient. METHODS: This retrospective study enrolled 122 patients (training: n = 63; and validation: n = 59) imaged between May 2015 and February 2020. In the training cohort, manual segmentation was performed on the ADC maps to obtain the ADC data of each patient, and these ADC data were summated to obtain the "All-patient" ADC data. Cluster analysis (three clusters) was performed on this All-patient ADC data, and the ADC ranges of each cluster were defined as follows: cluster 1, 490-699 × 10-6 mm2/s; cluster 2, 700-932 × 10-6 mm2/s; and cluster 3, over 933 × 10-6 mm2/s. In the training and validation cohorts, the ADC data of each patient was classified into three clusters according to these ADC ranges. The cluster ratios of each patient were calculated and compared with histological grade. RESULTS: In the training cohort, a significant positive correlation was found between the cluster 1 ratio and histological grade (ρ = 0.34, p = 0.0059). The cluster 1 ratios of high-grade lesions (grade 3) were significantly higher than those of low-grade lesions (grades 1 and 2) (p = 0.0084). A similar significant positive correlation was found between the cluster 1 ratio and histological grade in the validation cohort (ρ = 0.44, p = 0.0006). CONCLUSIONS: The cluster 1 ratio containing voxels with low ADC was significantly correlated with the histological grade of endometrioid carcinoma. KEY POINTS: • We performed Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma. • The cluster 1 ratio, which included low ADC values, was significantly positive correlated with histological grade in the training and validation cohorts. • The GMM-based cluster analysis of voxel-based ADC data was effective for grading endometrioid carcinoma.
Aldosterone-induced cardiac damage in primary aldosteronism depends on its subtypes. International-journal

Satoshi Higuchi, Hideki Ota, Yuta Tezuka, Kazumasa Seiji, Hidenobu Takagi, Jongmin Lee, Yi-Wei Lee, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, Kei Takase

Endocrine connections　10　(1)　29-36　2021/01

DOI： 10.1530/EC-20-0504 　

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Objectives: This study compared cardiac function, morphology, and tissue characteristics between two common subtypes of primary aldosteronism (PA) using a 3T MR scanner. Design: A retrospective, single-center, observational study. Methods: We retrospectively reviewed 143 consecutive patients with PA, who underwent both adrenal venous sampling and cardiac magnetic resonance. We acquired cine, late gadolinium enhancement, and pre- and postcontrast myocardial T1-mapping images. Results: PA was diagnosed as unilateral aldosterone-producing adenoma (APA) in 70 patients and bilateral hyperaldosteronism (BHA) in 73. The APA group showed significantly higher plasma aldosterone concentration (PAC) and aldosterone to renin rate (ARR) than the BHA group. After controlling for age, sex, antihypertensive drugs, systolic and diastolic blood pressure, and disease duration, the parameters independently associated with APA were: left ventricular end-diastolic volume index (EDVI: adjusted odds ratio (aOR) = 1.06 (95% CI: 1.030-1.096), P < 0.01), end-systolic volume index (ESVI: 1.06 (1.017-1.113), P < 0.01), stroke index (SI: 1.07 (1.020-1.121), P < 0.01), cardiac index (CI: 1.001 (1.000-1.001), P < 0.01), and native T1 (1.01 (1.000-1.019), P = 0.038). Weak positive correlations were found between PAC and EDVI (R = 0.28, P < 0.01), ESVI (0.26, P < 0.01), and SI (0.18, P = 0.03); and between ARR and EDVI (0.25, P < 0.01), ESVI (0.24, P < 0.01), and native T1 (0.17, P = 0.047). Conclusions: APA is associated with greater LV volumetric parameters and higher native T1 values, suggesting a higher risk of volume overload and myocardial damage.
Embolization of a paraumbilical shunt by the transparaumbilical venous approach and one-sheath inverse method: A case report

Hiroki Kamada, Hideki Ota, Kazumasa Seiji, Kei Takase

Radiology Case Reports　15　(11)　2125-2128　2020/11

DOI： 10.1016/j.radcr.2020.08.030 　

eISSN： 1930-0433
Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney. International-journal

Tomoyuki Iwasaki, Eikan Mishima, Takehiro Suzuki, Koichi Kikuchi, Takafumi Toyohara, Kazumasa Seiji, Kei Takase, Mariko Miyazaki, Hideo Harigae, Sadayoshi Ito, Takaaki Abe

Hypertension research : official journal of the Japanese Society of Hypertension　43　(11)　1214-1221　2020/11

DOI： 10.1038/s41440-020-0473-6 　

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Renal artery stenosis causes kidney ischemia, reducing the size of the affected kidney, which eventually results in atrophy. Although renal atrophy is considered irreversible, resolution of the ischemia occasionally restores kidney size when the cause is renal artery stenosis. Angioplasty is effective in patients with nonatherosclerotic renovascular diseases (non-ARVDs). Nevertheless, renal enlargement after angioplasty has not been fully examined. We conducted a retrospective study to examine this phenomenon in non-ARVD patients. Ten patients with a <100-mm pole-to-pole length of the poststenotic kidney were treated with angioplasty. Data were collected up to 12 months after angioplasty. The mean age was 28 years; the estimated glomerular filtration rate was 92 ± 7 mL/min/1.73 m2 (mean ± SEM); blood pressure was 150/99 mmHg; 80% were women; and fibromuscular dysplasia was present in 90% of the patients. All patients had hypertension. The lengths of the poststenotic and contralateral kidney before angioplasty were 91 ± 1 and 111 ± 3 mm, respectively. After angioplasty, the length of the poststenotic kidney gradually increased during the 3 months after treatment (+5.4 mm) and that of the contralateral kidney decreased over the same time course (-3.7 mm). Enlargement was also found in the moderate atrophy subgroup (length < 92 mm), and it was greater in the <30 years old group. In a noteworthy case, renal size in the poststenotic kidney recovered from 87 to 102 mm after angioplasty. Our findings demonstrated that reduced renal size can be reversed after optimal angioplasty in non-ARVD patients, especially young patients, suggesting reversibility of the ischemic kidney.
生体肝移植後の晩期胆道閉塞に対し超音波ガイド下に経皮的胆道空腸瘻形成を行った1例

影山咲子, 大田英揮, 鎌田裕基, 高瀬圭, 宮城重人

超音波医学　47　(Suppl.)　S286-S286　2020/11
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
Prognostic value of FDG-PET radiomics with machine learning in pancreatic cancer. International-journal

Yoshitaka Toyama, Masatoshi Hotta, Fuyuhiko Motoi, Kentaro Takanami, Ryogo Minamimoto, Kei Takase

Scientific reports　10　(1)　17024-17024　2020/10/12

DOI： 10.1038/s41598-020-73237-3 　

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Patients with pancreatic cancer have a poor prognosis, therefore identifying particular tumor characteristics associated with prognosis is important. This study aims to investigate the utility of radiomics with machine learning using 18F-fluorodeoxyglucose (FDG)-PET in patients with pancreatic cancer. We enrolled 161 patients with pancreatic cancer underwent pretreatment FDG-PET/CT. The area of the primary tumor was semi-automatically contoured with a threshold of 40% of the maximum standardized uptake value, and 42 PET features were extracted. To identify relevant PET parameters for predicting 1-year survival, Gini index was measured using random forest (RF) classifier. Twenty-three patients were censored within 1 year of follow-up, and the remaining 138 patients were used for the analysis. Among the PET parameters, 10 features showed statistical significance for predicting overall survival. Multivariate analysis using Cox HR regression revealed gray-level zone length matrix (GLZLM) gray-level non-uniformity (GLNU) as the only PET parameter showing statistical significance. In RF model, GLZLM GLNU was the most relevant factor for predicting 1-year survival, followed by total lesion glycolysis (TLG). The combination of GLZLM GLNU and TLG stratified patients into three groups according to risk of poor prognosis. Radiomics with machine learning using FDG-PET in patients with pancreatic cancer provided useful prognostic information.
Effective apparent diffusion coefficient parameters for differentiation between mass-forming autoimmune pancreatitis and pancreatic ductal adenocarcinoma

Hainan Ren, Naoko Mori, Shin Hamada, Chiaki Takasawa, Shunji Mugikura, Atsushi Masamune, Kei Takase

Abdominal Radiology　2020/10/10
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00261-020-02795-x 　

ISSN： 2366-004X

eISSN： 2366-0058
【研修医に教える画像診断のABC】検査時のポイント CT検査

小黒草太, 柳垣聡, 高瀬圭

臨床画像　36　(10月増刊)　6-17　2020/10
Publisher: (株)メジカルビュー社
ISSN： 0911-1069
【内分泌腺腫瘍(第2版)-基礎・臨床研究のアップデート-】副腎腫瘍副腎腫瘍の検査・診断画像診断

木下知, 清治和将, 高瀬圭

日本臨床　78　(増刊4 内分泌腺腫瘍)　635-641　2020/09
Publisher: (株)日本臨床社
ISSN： 0047-1852
リンパ管造影を施行した原発性乳糜心膜症の一例

影山咲子, 大田英揮, 高浪健太郎, 矢尾板信裕, 高瀬圭

日本インターベンショナルラジオロジー学会雑誌　35　(Suppl.)　290-291　2020/08
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520

eISSN： 2185-6451
Dose-dependent Radiation-induced Myocardial Damage in Esophageal Cancer Treated with Chemoradiotherapy: A Prospective Cardiac Magnetic Resonance Imaging Study Peer-reviewed

Rei Umezawa, Noriyuki Kadoya, Hideki Ota, Yujiro Nakajima, Masahide Saito, Hidenobu Takagi, Kentaro Takanami, Noriyoshi Takahashi, Yojiro Ishikawa, Takaya Yamamoto, Haruo Matsushita, Ken Takeda, Kei Takase, Keiichi Jingu

Advances in Radiation Oncology　5　(6)　1170-1178　2020/08
Publisher: Elsevier BV
DOI： 10.1016/j.adro.2020.07.012 　

ISSN： 2452-1094
Detection of the intimal tear in aortic dissection and ulcer-like projection in intramural hematoma: usefulness of full-phase retrospective ECG-gated CT angiography

Satoru Yanagaki, Takuya Ueda, Atsuro Masuda, Hideki Ota, Yuta Onaka, Masatoshi Kojima, Takashi Hattori, Wahei Mihara, Kei Takase

Japanese Journal of Radiology　2020/07/24
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11604-020-01008-1 　

ISSN： 1867-1071

eISSN： 1867-108X
Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis. International-journal Peer-reviewed

Michiko Kano, Cecilia Grinsvall, Qian Ran, Patrick Dupont, Joe Morishita, Tomohiko Muratsubaki, Shunji Mugikura, Huynh Giao Ly, Hans Törnblom, Maria Ljungberg, Kei Takase, Magnus Simrén, Lukas Van Oudenhove, Shin Fukudo

Scientific reports　10　(1)　11015-11015　2020/07/03

DOI： 10.1038/s41598-020-67048-9 　

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Irritable bowel syndrome (IBS) is a functional disorder of brain-gut interactions. Differential brain responses to rectal distention between IBS and healthy controls (HCs) have been demonstrated, particularly in the pain matrix and the default mode network. This study aims to compare resting-state functional properties of these networks between IBS patients and HCs using graph analysis in two independent cohorts. We used a weighted graph analysis of the adjacency matrix based on partial correlations between time series in the different regions in each subject to determine subject specific graph measures. These graph measures were normalized by values obtained in equivalent random networks. We did not find any significant differences between IBS patients and controls in global normalized graph measures, hubs, or modularity structure of the pain matrix and the DMN in any of our two independent cohorts. Furthermore, we did not find consistent associations between these global network measures and IBS symptom severity or GI-specific anxiety but we found a significant difference in the relationship between measures of psychological distress (anxiety and/or depressive symptoms) and normalized characteristic path length. The responses of these networks to visceral stimulation rather than their organisation at rest may be primarily disturbed in IBS.
乳癌患者における化学療法による心毒性が原因の局所左室変形に関する経時的変化(Longitudinal Change of Regional Left Ventricular Deformation by Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

藤原淳子, 後岡広太郎, 杉村宏一郎, 照井洋輔, 佐藤遥, 多田寛, 大田英揮, 船水康陽, 三木俊, 西條芳文, 高瀬圭, 石田孝宜, 下川宏明

日本循環器学会学術集会抄録集　84回　OJ12-6　2020/07
Publisher: (一社)日本循環器学会
乳癌患者における化学療法による心毒性が原因の局所左室変形に関する経時的変化(Longitudinal Change of Regional Left Ventricular Deformation by Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

藤原淳子, 後岡広太郎, 杉村宏一郎, 照井洋輔, 佐藤遥, 多田寛, 大田英揮, 船水康陽, 三木俊, 西條芳文, 高瀬圭, 石田孝宜, 下川宏明

日本循環器学会学術集会抄録集　84回　OJ12-6　2020/07
Publisher: (一社)日本循環器学会
18F-FDG PET/CT Imaging of Vasculitis Complicated With Relapsing Polychondritis. International-journal

Hiroki Kamada, Kentaro Takanami, Yoshitaka Toyama, Mioko Saito, Kei Takase

Clinical nuclear medicine　45　(7)　e327-e328　2020/07

DOI： 10.1097/RLU.0000000000003060 　

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We present a case of a 38-year-old woman who complained with cough, fever, and back pain with a weight loss. F-FDG PET/CT to search fever origin revealed uptake in the tracheobronchial and the left auricular cartilage and wall of the thoracic aorta. She underwent biopsy of the left auricle and was diagnosed with relapsing polychondritis (RP) complicating vasculitis. After steroid therapy, FDG PET/CT demonstrated regression of inflammation, showing decreases in the uptakes. Vasculitis should be considered in case of RP with systemic manifestations. Our case demonstrated the utility of FDG PET/CT in evaluation of RP lesions including aortitis.
Thrombosis of a basilar perforator aneurysm associated with pontine infarction in a patient with systemic lupus erythematosus

Takaki Murata, Shuko Nomura, Eiko Yamamori, Shoki Takahashi, Kei Takase

Radiology Case Reports　15　(6)　757-760　2020/06/01
Publisher: Elsevier Inc
DOI： 10.1016/j.radcr.2020.03.009 　

ISSN： 1930-0433
Clinical implication of myocardial FDG uptake pattern in oncologic PET: retrospective comparison study with stress myocardial perfusion imaging as the reference standard

Kentaro Takanami, Mioko Saito, Yasuharu Matsumoto, Koichiro Sugimura, Kei Takase

Annals of Nuclear Medicine　34　(4)　233-243　2020/04

DOI： 10.1007/s12149-020-01437-y 　

ISSN： 0914-7187

eISSN： 1864-6433
【腎・泌尿器の画像診断update】原発性アルドステロン症の診断・治療

清治和将, 大田英揮, 手塚雄太, 尾股慧, 小野美澄, 森本玲, 佐藤文俊, 高瀬圭

画像診断　40　(6)　589-605　2020/04
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
Turbo Spin-echo Diffusion-weighted Imaging Compared with Single-shot Echo-planar Diffusion-weighted Imaging: Image Quality and Diagnostic Performance When Differentiating between Ductal Carcinoma in situ and Invasive Ductal Carcinoma. Peer-reviewed

Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yui Maekawa, Tatsuo Nagasaka, Kei Takase

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　20　(1)　60-68　2020/03/06

DOI： 10.2463/mrms.mp.2019-0195 　

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PURPOSE: To compare the image quality between turbo spin-echo (TSE)-diffusion weighted imaging (DWI) and single-shot echo-planar imaging (EPI)-DWI, and to verify the diagnostic performance of the apparent diffusion coefficient (ADC) parameters of the two techniques by using histogram analysis in terms of differentiation between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) lesions. METHODS: Ninety-four women with 94 lesions diagnosed as breast cancer by surgery underwent IRB-approved preoperative magnetic resonance imaging, including TSE and EPI-DWI with b-values of 50 and 850 s/mm2. Twenty lesions were identified as DCIS and 74 as IDC. Image quality [signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and geometric distortion] was evaluated quantitatively and compared between the TSE and EPI-DWI. A histogram analysis of the entire tumor voxel-based ADC data was performed, and the 10th, 25th, 50th, 75th, and 90th percentile values of each technique were compared between DCIS and IDC lesions. RESULTS: The SNR and CNR of TSE-DWI were significantly higher than those of EPI-DWI (P < 0.0001 and < 0.0001). The geometric distortion of TSE-DWI was significantly lower than that of EPI-DWI (P < 0.0001). In TSE-DWI, the 10th, 25th, 50th, and 75th percentile values were significantly different between the DCIS and IDC lesions (P = 0.0010, 0.0004, 0.0008, and 0.0044, respectively). In EPI-DWI, the 50th and 75th percentile values were significantly different between the two groups (P = 0.0009 and 0.0093). There was no significant difference in the area under the curve of the receiver operating characteristic analysis of the 10th, 25th, 50th, and 75th percentile values of TSE-DWI, and the 50th and 75th percentile values of EPI-DWI (P = 0.29). CONCLUSION: The image quality of TSE-DWI was better than that of EPI-DWI. DCIS lesions were distinguished from IDC lesions with a wider range of percentile values in TSE-DWI than in EPI-DWI, although diagnostic performance was not significantly different between the techniques.
Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm Peer-reviewed

Shunji Mugikura, Naoko Mori, Hirokazu Kikuchi, Etsuro Mori, Shoki Takahashi, Kei Takase

Annals of Nuclear Medicine　34　(3)　220-227　2020/03
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12149-020-01436-z 　

ISSN： 0914-7187

eISSN： 1864-6433

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<title>Abstract</title><sec> <title>Objective</title> Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia. </sec><sec> <title>Methods</title> Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on ¹²³I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. The Severity (average <italic>Z</italic> score of the voxels with a <italic>Z</italic> score that exceeds a threshold value of 2) was calculated. The cerebral lobes with rCBF exhibiting Severity > 2 in all patients were identified. In these lobes, we then examined whether there was a gyrus exhibiting Severity that was negatively related to memory quotients (MQs). </sec><sec> <title>Results</title> In the right subcallosal gyrus, there was a significant negative correlation between Severity and visual MQ (<italic>ρ</italic>= − 0.884, <italic>p</italic> = 0.0007) or general MQ (<italic>ρ</italic> =− 0.853, <italic>p</italic> = 0.0017). In the right anterior cingulate gyrus, there was a significant negative correlation between Severity and verbal MQ (<italic>ρ</italic> = − 0.769, <italic>p</italic> = 0.0092). In the right rectal gyrus, there was a significant negative correlation between Severity and general MQ (<italic>ρ</italic> = − 0.811, <italic>p</italic> = 0.0044). No significant correlations were found between Severity in other brain regions and verbal, visual, or general MQ. </sec><sec> <title>Conclusions</title> The decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia. </sec>
Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm.

Shunji Mugikura, Naoko Mori, Hirokazu Kikuchi, Etsuro Mori, Shoki Takahashi, Kei Takase

Annals of nuclear medicine　34　(3)　220-227　2020/03

DOI： 10.1007/s12149-020-01436-z 　

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OBJECTIVE: Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia. METHODS: Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on 123I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. The Severity (average Z score of the voxels with a Z score that exceeds a threshold value of 2) was calculated. The cerebral lobes with rCBF exhibiting Severity > 2 in all patients were identified. In these lobes, we then examined whether there was a gyrus exhibiting Severity that was negatively related to memory quotients (MQs). RESULTS: In the right subcallosal gyrus, there was a significant negative correlation between Severity and visual MQ (ρ= - 0.884, p = 0.0007) or general MQ (ρ =- 0.853, p = 0.0017). In the right anterior cingulate gyrus, there was a significant negative correlation between Severity and verbal MQ (ρ = - 0.769, p = 0.0092). In the right rectal gyrus, there was a significant negative correlation between Severity and general MQ (ρ = - 0.811, p = 0.0044). No significant correlations were found between Severity in other brain regions and verbal, visual, or general MQ. CONCLUSIONS: The decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia.
4D-flow MRI assessment of blood flow before and after endovascular intervention in a patient with pulmonary hypertension due to isolated pulmonary artery involvement in large vessel vasculitis. International-journal

Hiroki Kamada, Hideki Ota, Tatsuo Aoki, Koichiro Sugimura, Nobuhiro Yaoita, Hiroaki Shimokawa, Kei Takase

Radiology case reports　15　(3)　190-194　2020/03

DOI： 10.1016/j.radcr.2019.11.019 　

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A 43-year-old woman presented with dyspnea during exertion and lower leg edema. Contrast-enhanced computed tomography images demonstrated extensive proximal narrowing in the right main pulmonary artery with thickening and enhancement. Right heart catheterization revealed the presence of precapillary pulmonary hypertension with a mean pulmonary arterial pressure of 45 mm Hg. The patient was diagnosed with large-vessel vasculitis with isolated pulmonary artery involvement. Takayasu's arteritis was suspected, but histological examination was not performed. Several sessions of pulmonary arterial intervention were stratified for the right main pulmonary artery. After treatment, mean pulmonary arterial pressure had decreased to 22 mm Hg with improvement in symptoms. Thoracic 4D-flow magnetic resonance imaging was performed before and after intervention to evaluate the volume flow rates of pulmonary arteries. The rates increased at the inlet of the right pulmonary artery (before: 23 mL/s vs after: 47.5 mL/s) and the main pulmonary artery (before: 71.2 mL/s vs after: 82.5 mL/s), and decreased at the inlet of the left pulmonary artery (before: 46.2 mL/s vs after: 31.7 mL/s). The split ratio of volume flow rate between the right and left pulmonary arteries improved after treatment (before. right:left = 33.1:66.9; after, right:left = 60.0:40.0), approaching normal values. This report quantitatively describes perioperative hemodynamic changes in a patient with pulmonary hypertension using 4D-flow magnetic resonance imaging. Stent placement for stenosis in the right pulmonary artery resulted in an increase in overall pulmonary blood flow and also improved blood flow balance between the right and the left pulmonary arteries.
大脳表在静脈への還流障害を来したサルコイドーシスの1例

竹下翔, 明石敏昭, 佐藤志帆, 北見昌広, 村田隆紀, 梅津篤司, 麦倉俊司, 高瀬圭

Japanese Journal of Radiology　38　(Suppl.)　1-1　2020/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
肝胆膵領域術後出血に対する治療戦略膵頭十二指腸切除術術後出血の治療戦略

森川孝則, 水間正道, 青木修一, 畠達夫, 三浦孝之, 高舘達之, 有明恭平, 川口桂, 益田邦洋, 石田晶玄, 大塚英郎, 中川圭, 林洋毅, 元井冬彦, 亀井尚, 内藤剛, 高瀬圭, 海野倫明

日本腹部救急医学会雑誌　40　(2)　266-266　2020/02
Publisher: (一社)日本腹部救急医学会
ISSN： 1340-2242

eISSN： 1882-4781
肝胆膵領域術後出血に対する治療戦略膵頭十二指腸切除術術後出血の治療戦略 Peer-reviewed

森川孝則, 水間正道, 青木修一, 畠達夫, 三浦孝之, 高舘達之, 有明恭平, 川口桂, 益田邦洋, 石田晶玄, 大塚英郎, 中川圭, 林洋毅, 元井冬彦, 亀井尚, 内藤剛, 高瀬圭, 海野倫明

日本腹部救急医学会雑誌　40　(2)　266-266　2020/02
Publisher: (一社)日本腹部救急医学会
ISSN： 1340-2242

eISSN： 1882-4781
縦隔に発生したFollicular dendritic cell sarcomaの1例

竹下翔, 佐藤嘉尚, 冨永循哉, 高瀬圭, 井上千裕, 齊藤涼子

Japanese Journal of Radiology　38　(Suppl.)　6-6　2020/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
中期経過観察された食道癌化学放射線療法後における心事故と心臓MRI所見の関連性

梅澤玲, 角谷倫之, 松下晴雄, 山本貴也, 石川陽二郎, 片桐佑, 武田一也, 福井勝哉, 田坂俊, 鈴木友, 川端広聖, 岸田桂太, 寺村聡司, 尾股聡, 伊藤謙吾, 高山佳樹, 千葉貴仁, 神宮啓一, 大田英揮, 高瀬圭

Japanese Journal of Radiology　38　(Suppl.)　9-9　2020/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
Unique Sex Steroid Profiles in Estrogen-Producing Adrenocortical Adenoma Associated With Bilateral Hyperaldosteronism. International-journal Peer-reviewed

Yuta Tezuka, Yuto Yamazaki, Yoshikiyo Ono, Ryo Morimoto, Kei Omata, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Akihiro Ito, Yasuhiro Nakamura, Hideo Harigae, Hironobu Sasano, Fumitoshi Satoh

Journal of the Endocrine Society　4　(2)　bvaa004　2020/02/01

DOI： 10.1210/jendso/bvaa004 　

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Because of its rarity, our understanding of steroidogenesis in estrogen-producing adrenocortical adenoma, including the response to adrenocorticotropic hormone (ACTH) stimulation, remains limited. A 65-year-old man was referred to us because of primary aldosteronism and a right adrenal tumor. Endocrinological evaluations revealed secondary hypogonadism due to hyperestrogenemia. Adrenal venous sampling (AVS) and subsequent liquid chromatography-tandem mass spectrometry (LC-MS/MS) indicated bilateral hyperaldosteronism and a right estrogen-producing adrenocortical tumor. He subsequently underwent right unilateral adrenalectomy, which resulted in clinical remission of hypogonadism. Subsequent histopathological analysis identified a right estrogen-producing adrenocortical adenoma and multiple, concomitant adrenocortical micronodules. Sequential evaluation of steroid profiles using LC-MS/MS revealed unique hormone production, including adrenal androgens, and less responsiveness to ACTH in the right estrogen-producing adrenocortical adenoma as compared to the nonneoplastic adrenal cortex. This case study revealed unique profiles of steroid production in estrogen-producing adrenocortical adenoma associated with concomitant primary aldosteronism. Sequential steroid profiling analysis using LC-MS/MS in combination with AVS can contribute to the diagnosis of various adrenal disorders.
Apparent Diffusion Coefficient in the Resolution of Renal Ischemia after Angioplasty on Diffusion-weighted Imaging: A Case of Renal Artery Stenosis Caused by Progressive Thrombosis in Residual Chronic Aortic Dissection. Peer-reviewed

Eikan Mishima, Hideki Ota, Takehiro Suzuki, Takafumi Toyohara, Kazumasa Seiji, Sadayoshi Ito, Yoshikatsu Saiki, Kei Takase, Takaaki Abe

Internal medicine (Tokyo, Japan)　2020/01/17

DOI： 10.2169/internalmedicine.3855-19 　

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We report a case in which diffusion-weighted magnetic resonance imaging (DWI) demonstrated renal artery stenosis-related renal ischemia and the therapeutic efficacy of revascularization. The patient was a 73-year-old man, who underwent descending thoracic aortic replacement due to DeBakey IIIb chronic aortic dissection, and who showed progressive renal dysfunction due to right renal artery stenosis caused by false lumen thrombosis. DWI demonstrated a decreased apparent diffusion coefficient (ADC) in the right kidney, indicating renal ischemia. Angioplasty with stenting restored renal perfusion and improved the renal function, resulting in the normalization of the decreased ADC in the treated kidney. Thus, DWI can be used to monitor renal ischemia in cases involving advanced renal artery stenosis.
Three cases of pulmonary tumor thrombotic microangiopathy (PTTM): Challenge in antemortem diagnosis using lung perfusion blood volume images by dual-energy computed tomography. International-journal

Hiroki Kamada, Hideki Ota, Yosuke Terui, Koichiro Sugimura, Shigefumi Fukui, Hiroaki Shimokawa, Kei Takase

European journal of radiology open　7　100212-100212　2020

DOI： 10.1016/j.ejro.2020.01.001 　

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Pulmonary tumor thrombotic microangiopathy (PTTM) is a specific type of tumor embolism in the small and medium pulmonary arteries, leading to rapid progressive pulmonary hypertension. Antemortem diagnosis of PTTM is extremely difficult. We encountered three patients who were histopathologically or clinically diagnosed with PTTM. In all cases, lung perfused blood volume (PBV) images on dual-energy computed tomography (CT) demonstrated multiple subpleural wedge-shaped defects with no evidence of pulmonary embolism on CT pulmonary angiography. The lung PBV images demonstrated small pulmonary arterial obstruction reflecting the pathology of PTTM. Therefore, lung PBV imaging would be useful for antemortem diagnosis of PTTM.
結腸癌に連続するFDG高集積のPET/CT所見と病理所見の比較検討

加賀谷由里子, 外山由貴, 太田瑛梨, 前川由依, 齊藤美穂子, 高浪健太郎, 高瀬圭, 渡辺みか, 藤島史喜

核医学　57　(1)　4-5　2020
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
FDG-PETで指摘し得た顕微鏡的多発血管炎(MPA)の1症例

太田瑛梨, 加賀谷由里子, 前川由依, 外山由貴, 齊藤美穂子, 高浪健太郎, 高瀬圭

核医学　57　(1)　5-5　2020
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
当院における半導体PET/CTの初期経験

高浪健太郎, 外山由貴, 太田瑛梨, 加賀谷由里子, 前川由依, 齊藤美穂子, 高瀬圭

核医学　57　(1)　5-5　2020
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
最新半導体PET/CTにおける上腹部病変への呼吸同期の有用性

外山由貴, 高浪健太郎, 太田瑛梨, 加賀谷由里子, 前川由依, 齊藤美穂子, 高瀬圭

核医学　57　(1)　5-5　2020
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
後腹膜腫瘍切除後椎骨動脈瘤破裂による気道閉塞から心肺停止をきたした神経線維腫症I型の1救命例

三浦孝之, 水間正道, 元井冬彦, 内藤剛, 亀井尚, 高瀬圭, 海野倫明

Japanese Journal of Acute Care Surgery　9　(2)　254-257　2020/01
Publisher: 日本Acute Care Surgery学会
eISSN： 2436-102X
Perioperative Hemodynamic Changes in the Thoracic Aorta in Patients With Aortic Valve Stenosis: A Prospective Serial 4D-Flow MRI Study. International-journal Peer-reviewed

Hiroki Kamada, Hideki Ota, Masanori Nakamura, Yohsuke Imai, Shunichi Ishida, Wenyu Sun, Ko Sakatsume, Ichiro Yoshioka, Yoshikatsu Saiki, Kei Takase

Seminars in thoracic and cardiovascular surgery　32　(1)　25-34　2020

DOI： 10.1053/j.semtcvs.2019.07.006 　

ISSN： 1043-0679

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This study investigated hemodynamic changes in the thoracic aorta and aortic arch branches before and after aortic valve replacement (AVR) by 4D-flow MRI in patients with aortic valve stenosis (AS). Thoracic 4D-flow MRI was performed in 10 AS patients before and after AVR (mean 27 ± 1.9 days). Fifteen aortic planes and 3 aortic arch branches planes were set to evaluate the mean volume flow rate in each plane during a cardiac cycle and the angle between the main flow direction in a specified plane and the axial direction of the aorta. We also focused on the distribution and magnitude of helicity density to evaluate the flow complexity. A significant increase in the volume flow rate after AVR was found in the ascending aorta (before 59.2 ± 8.7 mL/s vs after 77.3 ± 6.2 mL/s, P < 0.05) and the aortic arch branches (before 26.5 ± 2.8 mL/s vs after 35.8 ± 3.3 mL/s, P < 0.001). The flow angle significantly decreased in the ascending aorta (before 39.2 ± 2.7 degree vs after 25.2 ± 1.7°, P < 0.0001) and the arch aorta (before 19.3 ± 2.0 degree vs after 13.4 ± 0.9°, P < 0.001). The volume flow rate in the ascending aorta and the arch branches increased within 1 month after AVR, showing an increased blood supply to the upper body, including to the brain. The postoperative change was accompanied with an increased blood flow in the ascending aorta and a decreased flow complexity proximal to the arch branches.
Insula Activity to Visceral Stimulation and Endocrine Stress Responses as Associated With Alexithymia in Patients With Irritable Bowel Syndrome. International-journal Peer-reviewed

Michiko Kano, Tomohiko Muratsubaki, Mao Yagihashi, Joe Morishita, Shunji Mugikura, Patrick Dupont, Kei Takase, Motoyori Kanazawa, Lukas Van Oudenhove, Shin Fukudo

Psychosomatic medicine　82　(1)　29-38　2020/01

DOI： 10.1097/PSY.0000000000000729 　

ISSN： 0033-3174

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OBJECTIVE: Few studies have investigated associations between alexithymia and physiological mechanisms in psychosomatic diseases. We examined associations between alexithymia and 1) perception and brain processing of visceral stimulation and 2) the endocrine responses to corticotrophin-releasing hormone (CRH) in healthy individuals and patients with irritable bowel syndrome (IBS). METHODS: The study included 29 patients with IBS and 35 age- and sex-matched healthy controls (HCs). Alexithymia was measured using the 20-item Toronto Alexithymia Scale (TAS-20). Brain responses to rectal distention and its anticipation were measured by functional magnetic resonance imaging and analyzed at a voxel-level threshold of puncorrected < .001 combined with a cluster-level threshold of pFWE-corrected < .05. On a different day, plasma adrenocorticotropic hormone and cortisol responses after intravenous CRH administration were measured. RESULTS: TAS-20 scores did not differ significantly between patients with IBS and HCs (p = .18). TAS-20 scores correlated positively with the individual rectal discomfort thresholds (βrobust = 0.49, p = .03) and negatively with the rating of fear before rectal distention (βrobust = -1.63, p = .04) in patients with IBS but not in HCs. Brain responses to rectal distention in the right insula and other brain regions were positively associated with TAS-20 scores to a greater extent in patients with IBS than in HCs. Individuals with higher TAS-20 scores (both patients with IBS and HCs) demonstrated stronger adrenocorticotropic hormone responses to CRH administration (F(4,224) = 3.54, p = .008). CONCLUSION: Higher alexithymia scores are associated with stronger physiological responses, but lower anticipatory fear ratings and higher discomfort thresholds, particularly in patients with IBS.
Association of the incidence of venous air embolism on coronary computed tomography angiography with the intravenous access route preparation process. Peer-reviewed

Kayano S, Ota H, Yamaguchi T, Ono K, Takase K

Medicine　98　(45)　e17940　2019/11

DOI： 10.1097/MD.0000000000017940 　

ISSN： 0025-7974

eISSN： 1536-5964
【肝胆膵の救急疾患とその最新の治療現場】肝胆膵領域疾患への新しいmodality Stent-assisted coil embolizationによる臓器血流温存下塞栓術

長谷川哲也, 高瀬圭

肝胆膵　79　(4)　747-753　2019/10
Publisher: (株)アークメディア
ISSN： 0389-4991
CardioOncologyの現状と未来当院データと本邦における多施設共同研究への発展

杉村宏一郎, 大田英揮, 多田寛, 照井洋輔, 佐藤遥, 後岡広太郎, 石田孝宣, 高瀬圭, 下川宏明

日本心臓病学会学術集会抄録　67回　SS-3　2019/09
Publisher: (一社)日本心臓病学会
非典型的な臨床経過と画像を示した器質化肺炎の1例

佐藤嘉尚, 冨永循哉, 齊藤涼子, 高瀬圭

日本医学放射線学会秋季臨床大会抄録集　55回　S541-S541　2019/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

佐々木健吾, 宮城重人, 笹嶋秀憲, 宮崎勇希, 藤尾淳, 西村隆一, 中西渉, 戸子台和哲, 大田英揮, 高瀬圭, 亀井尚, 海野倫明

移植　54　(総会臨時)　200-200　2019/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
頭部CT Angiographyを想定するヒストグラム解析を用いた撮影タイミングの決定法に関する基礎的検証

茅野伸吾, 藤盛陽介, 高野博和, 高根侑美, 大村知己, 千葉雄高, 大田英揮, 高瀬圭

日本放射線技術学会雑誌　75　(9)　1075-1075　2019/09
Publisher: (公社)日本放射線技術学会
ISSN： 0369-4305

eISSN： 1881-4883
ちょっと気になる胆・膵画像ティーチングファイルから(第42回) 肝内外に多発病変を認めた胆管内乳頭状腫瘍の1例

影山咲子, 大田英揮, 前川由依, 高浪健太郎, 藤島史喜, 高瀬圭

胆と膵　40　(8)　661-664　2019/08
Publisher: 医学図書出版(株)
ISSN： 0388-9408
新型FDG PETで多数の神経節に集積を認めたNeurolymphomatosisの一例

加藤恵里奈, 外山由貴, 太田瑛梨, 高橋梢, 前川由依, 加賀谷由里子, 村田隆紀, 斎藤美穂子, 高浪健太郎, 高瀬圭

核医学　56　(1)　101-101　2019/07
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
当院でのLHIAS(心房中隔の脂肪腫様過形成)のFDG PET所見の検討

前川由依, 高浪健太郎, 太田瑛梨, 高橋梢, 加賀谷由里子, 外山由貴, 斎藤美穂子, 高瀬圭

核医学　56　(1)　101-101　2019/07
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Ultrafast Dynamic Contrast-Enhanced Breast MRI: Kinetic Curve Assessment Using Empirical Mathematical Model Validated with Histological Microvessel Density Peer-reviewed

Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Chiaki Takasawa, Satoko Sato, Minoru Miyashita, Yu Mori, Federico D. Pineda, Gregory S. Karczmar, Hajime Tamura, Shoki Takahashi, Kei Takase

Academic Radiology　26　(7)　e141-e149　2019/07

DOI： 10.1016/j.acra.2018.08.016 　

ISSN： 1076-6332

eISSN： 1878-4046
Effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling: a preliminary study using computational fluid dynamics. International-journal Peer-reviewed

Tomo Kinoshita, Kazumasa Seiji, Narendra Kurnia Putra, Tomohito Watanabe, Sho Matsumoto, Makoto Ohta, Kei Takase

Medical & biological engineering & computing　57　(7)　1425-1436　2019/07

DOI： 10.1007/s11517-019-01968-1 　

ISSN： 0140-0118

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This study aimed to evaluate the effect of a notch at the distal end of a microcatheter on vein deformation in segmental adrenal venous sampling. A three-dimensional fluid-structure interaction simulation was performed using commercial finite element software. A computational model of a vein with a catheter inserted into it was constructed. The outer and inner diameters of the vein were 0.9 mm and 0.6 mm, respectively, whereas those of the catheter were 0.6 mm and 0.5 mm, respectively. The velocity of the blood flow at the outlet was 85 mm/s. The pressure at the inlet was 0 Pa. The mesh consisted of approximately 660,000 elements. The effect of the number (0-4) and shape (no notch, 1/4 circular, 1/3 circular, semicircular, 2/3 circlecircular, and 3/4 circular) of the notches at the distal end of the microcatheter on the vein deformation when a suction pressure was applied was evaluated. The venous wall displacement was the smallest with the one-notch catheter, followed by the four-notch catheter, and was the smallest with the catheter having 1/4-circular notches, followed by the one with 1/3-circular notches. In conclusion, microcatheters having one notch and 1/4-circular notches reduce vein deformation and lead to successful segmental adrenal venous sampling. Graphical abstract Comparing catheters having different notch shapes.
Changes in quality of life after laparoscopic adrenalectomy for patients with primary aldosteronism: Prospective 2-year longitudinal cohort study in a Japanese tertiary center. Peer-reviewed

Ishidoya S, Kawasaki Y, Namiki S, Morimoto R, Takase K, Ito A

International journal of urology : official journal of the Japanese Urological Association　26　(7)　752-753　2019/07

DOI： 10.1111/iju.14016 　

ISSN： 0919-8172
Usefulness of Diffusion-Weighted Magnetic Resonance Imaging Using Apparent Diffusion Coefficient Values for Diagnosis of Infantile Hemangioma. Peer-reviewed

Saito M, Kitami M, Takase K

Journal of computer assisted tomography　43　(4)　563-567　2019/07

DOI： 10.1097/RCT.0000000000000884 　

ISSN： 0363-8715

eISSN： 1532-3145
Validating an Empirical Mathematical Model for Dynamic Contrast-enhanced MR Imaging of Hand and Wrist Synovitis in Rheumatoid Arthritis: Correlation of Model Parameters with Clinical Disease Activity. Peer-reviewed

Ochi J, Mori N, Mori Y, Mugikura S, Hitachi S, Itoi E, Takase K

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　19　(3)　176-183　2019/07

DOI： 10.2463/mrms.mp.2019-0026 　

ISSN： 1347-3182

eISSN： 1880-2206
急速に進行したMyxoid型副腎皮質癌の一例

手塚雄太, 森本玲, 白鳥ベアタ, 尾股慧, 小野美澄, 工藤正孝, 五十嵐康宏, 大田英揮, 高瀬圭, 宮城重人, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　95　(Suppl.Update)　77-80　2019/06
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X

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60歳女性。全身の浮腫を主訴とした。健康診断で高血圧を指摘され、2ヵ月後に浮腫が出現した。前医で左副腎腫瘍、ACTH分泌抑制を伴う高コルチゾール血症と診断され、精査目的に当科紹介受診となった。造影CT、MRIで肝臓と右肺野に腫瘤性病変を認め、前医との比較で肝病変の増大、新規病変が出現していた。左副腎皮質癌Stage IVに伴うCushing症候群と診断し、metyraponeを投与した。しかし、前医から当院紹介までの短期間に高コルチゾール血症の増悪、転移性腫瘤の増大を認めており、metyraponeでの管理が困難であった。開腹左副腎摘除術を施行し、病理診断はMyxoid型副腎皮質癌であった。術後1ヵ月後にEtoposide-Doxorubicin-Cisplatin(EDP)療法を行ったが、コルチゾール値の上昇、肝病変の増大、多数の新規病変の出現を認めた。EDP療法は無効と判断し、緩和医療へ移行した。肝転移の増大と肝不全で前医初診後1年に死亡した。
A case of iatrogenic air bubbles in the left ventricle by coronary computed tomographic angiography. International-journal Peer-reviewed

Kayano S, Takahashi A, Ota H, Takase K

Radiology case reports　14　(6)　687-691　2019/06

DOI： 10.1016/j.radcr.2019.03.017 　

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We report a case of asymptomatic iatrogenic air bubbles in the left ventricle observed by coronary computed tomographic angiography. Air bubbles are rarely found in the left ventricle and could prove fatal should they migrate to the brain or coronary arteries. We believe that the cause is micro air bubbles in the tubing system between the intravenous catheter and power injector.
18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status. International-journal Peer-reviewed

Yuta Tezuka, Yuto Yamazaki, Masaaki Kitada, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Koji Mitsuzuka, Akihiro Ito, Jun Nishikawa, Noriko Asai, Yasuhiro Nakamura, Celso E Gomez-Sanchez, Sadayoshi Ito, Mari Dezawa, Hironobu Sasano, Fumitoshi Satoh

Hypertension (Dallas, Tex. : 1979)　73　(6)　1283-1290　2019/06

DOI： 10.1161/HYPERTENSIONAHA.118.12064 　

ISSN： 0194-911X

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Peripheral 18-oxocortisol (18oxoF) level could contribute to the detection of aldosterone-producing adenoma (APA) in patients with primary aldosteronism. However, peripheral 18oxoF varies among such patients, which is a big drawback concerning its clinical application. We studied 48 cases of APA, 35 harboring KCNJ5 mutation, to clarify the significance of clinical and pathological parameters about peripheral 18oxoF. Peripheral 18oxoF concentration ranged widely from 0.50 to 183.13 ng/dL and correlated positively with intratumoral areas stained positively for steroidogenic enzymes ( P<0.0001). The peripheral 18oxoF level also correlated significantly with that of circulating aldosterone ( P<0.0001) but not with that of cortisol, a precursor of 18oxoF. However, a significant correlation was detected between peripheral 18oxoF and intratumoral glucocorticoids ( P<0.05). In addition, peripheral 18oxoF correlated positively with the number of hybrid cells double positive for 11β-hydroxylase and aldosterone synthase ( P<0.0001). Comparing between the cases with and those without KCNJ5 mutation, the KCNJ5-mutated group demonstrated a significantly higher concentration of peripheral 18oxoF (28.4±5.6 versus 3.0±0.9 ng/dL, P<0.0001) and a larger intratumoral environment including the hybrid cells ( P<0.001), possibly representing a deviation from normal aldosterone biosynthesis. After multivariate analysis, KCNJ5 mutation status turned out to be the most associated factor involved in 18oxoF synthesis in APA ( P<0.0001). Results of our present study first revealed that enhanced 18oxoF synthesis in APA could come from a functional deviation of aldosterone biosynthesis from the normal zona glomerulosa and the utility of peripheral 18oxoF measurement could be influenced by the prevalence of KCNJ5 mutation in an APA.
Parasympathetic activity correlates with subjective and brain responses to rectal distension in healthy subjects but not in non-constipated patients with irritable bowel syndrome. International-journal Peer-reviewed

Michiko Kano, Makoto Yoshizawa, Keiji Kono, Tomohiko Muratsubaki, Joe Morishita, Lukas Van Oudenhove, Mao Yagihashi, Shunji Mugikura, Patrick Dupont, Kei Takase, Motoyori Kanazawa, Shin Fukudo

Scientific reports　9　(1)　7358-7358　2019/05/14

DOI： 10.1038/s41598-019-43455-5 　

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The nociceptive and autonomic nervous systems (ANS) are significantly intertwined. Decoupling of these systems may occur in pathological pain conditions, including irritable bowel syndrome (IBS). We investigated ANS activity and its association with visceral perception and brain activity during rectal distention in 27 patients with non-constipated IBS and 33 controls by assessing heart rate variability (HRV) using electrocardiography at rest, before, and during colorectal distention. Brain responses to colorectal distention were measured using functional magnetic resonance imaging and correlated with individual ANS function parameters. The IBS group displayed blunted sympathovagal balance [low/high-frequency ratio (LF:HF) of HRV] in response to colorectal distention compared with controls (P = 0.003). In controls, basal parasympathetic tone (HF component of HRV) was significantly negatively correlated with toleration threshold to the rectal distention, but not in patients with IBS (group comparison P = 0.04). Further, a positive correlation between baseline HF values and neural responses to rectal distension was found in the right caudate, bilateral dorsolateral anterior cingulate cortex, and pregenual anterior cingulate cortex in the control group but not in the IBS group. The results indicate abnormal interactions between ANS activity and the brain mechanisms underlying visceral perception in patients with IBS.
腎動脈狭窄や腎内レニン産生の局在を認めない高レニン性高血圧の一例

菅原典子, 内田奈生, 木越隆晶, 佐々木太郎, 木村正人, 鈴木健弘, 阿部高明, 高瀬圭, 呉繁夫

日本小児腎臓病学会雑誌　32　(1Suppl.)　178-178　2019/05
Publisher: (一社)日本小児腎臓病学会
ISSN： 0915-2245

eISSN： 1881-3933
リンパ管造影が有効であったPulmonary lymphatic perfusion syndromeによる難治性乳び胸の一例

影山咲子, 大田英輝, 外山由貴, 高浪健太郎, 平野泰三, 藤野直也, 一ノ瀬正和, 高瀬圭

日本インターベンショナルラジオロジー学会雑誌　34　(Suppl.)　396-396　2019/05
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520

eISSN： 2185-6451
Atrophy of the ipsilateral mammillary body in unilateral hippocampal sclerosis shown by thin-slice-reconstructed volumetric analysis. International-journal Peer-reviewed

Yohei Morishita, Shunji Mugikura, Naoko Mori, Hajime Tamura, Shiho Sato, Toshiaki Akashi, Kazutaka Jin, Nobukazu Nakasato, Kei Takase

Neuroradiology　61　(5)　515-523　2019/05

DOI： 10.1007/s00234-019-02158-4 　

ISSN： 0028-3940

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PURPOSE: Conventional volumetric analysis could not detect ipsilateral atrophy of the mammillary body in patients with unilateral hippocampal sclerosis. By using thin-slice-reconstructed volumetric analysis, we investigated whether the mammillary body volume is smaller on the hippocampal sclerosis side than in healthy subjects or the non-hippocampal sclerosis side. METHODS: This retrospective study included 45 patients with unilateral hippocampal sclerosis and 30 healthy subjects. Three-dimensional T1WI of 1 mm thicknesses were oversampled to a thickness of 0.2 mm (thin-slice-reconstructed images), and the mammillary bodies were segmented manually to determine mammillary body volume on each side. Mammillary body volumes on the hippocampal sclerosis side were compared with those in healthy subjects or the non-hippocampal sclerosis side. RESULTS: In patients with right hippocampal sclerosis, right mammillary body volume was both significantly smaller than that in healthy subjects (30.3 ± 10.3 vs. 43.3 ± 8.07 mm3, P < 0.001) and significantly smaller than the left mammillary body volume in each patient (30.3 ± 10.3 vs. 41.4 ± 10.1 mm3, P < 0.001). Similarly, in patients with left hippocampal sclerosis, left mammillary body volume was both significantly smaller than that in healthy subjects (37.7 ± 11.2 vs. 47.0 ± 8.65 mm3, P < 0.001) and significantly smaller than right mammillary body volume in each patient (37.7 ± 11.2 vs. 42.5 ± 7.78 mm3, P = 0.044). CONCLUSIONS: In this study, thin-slice-reconstructed volumetric analysis showed that, in patients with unilateral hippocampal sclerosis, mammillary body volume on the hippocampal sclerosis side is smaller than that in healthy subjects and the non-hippocampal sclerosis side.
3T MRI evaluation of regional catecholamine-producing tumor-induced myocardial injury. International-journal Peer-reviewed

Satoshi Higuchi, Hideki Ota, Takuya Ueda, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, Kei Takase

Endocrine connections　8　(5)　454-461　2019/05/01

DOI： 10.1530/EC-18-0553 　

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Objective: Regional differences in cardiac magnetic resonance, which can reveal catecholamine-induced myocardial injury in patients with pheochromocytoma, have not yet been assessed using 3T magnetic resonance imaging. We evaluated these differences using myocardial T1-mapping and strain analysis. Design and Methods: We retrospectively reviewed 16 patients newly diagnosed with catecholamine-producing tumors (CPT group) and 16 patients with essential hypertension (EH group), who underwent cardiac magnetic resonance imaging between May 2016 and March 2018. We acquired 3T magnetic resonance cine and native T1-mapping images and performed feature-tracking-based strain analysis in the former. Results: Global cardiac function, morphology, global strain and peak strain rate were similar, but end-diastolic wall thickness differed between groups (CPT vs EH: 10.5 ± 1.7 vs 12.6 ± 2.8 mm; P < 0.05). Basal, but not apical, circumferential strain was significantly higher in the CPT than the EH group (19.4 ± 3.2 vs 16.8 ± 3.6 %; P < 0.05). Native T1 values were significantly higher in CPT than in EH patients, in both the basal septum (1307 ± 48 vs 1241 ± 45 ms; P < 0.01) and the apical septum (1377 ± 59 vs 1265 ± 58 ms; P < 0.01) mid-walls. In the CPT, but not in the EH group, native T1 values in the apical wall were significantly higher than those in the basal wall (P < 0.01). Conclusion: 3T magnetic resonance-based T1-mapping can sensitively detect subclinical catecholamine-induced myocardial injury; the influence of catecholamines may be greater in the apical than in the basal wall.
Diagnostic value of electric properties tomography (EPT) for differentiating benign from malignant breast lesions: comparison with standard dynamic contrast-enhanced MRI. Peer-reviewed

Mori N, Tsuchiya K, Sheth D, Mugikura S, Takase K, Katscher U, Abe H

European radiology　29　(4)　1778-1786　2019/04

DOI： 10.1007/s00330-018-5708-4 　

ISSN： 0938-7994
Perfusion contrast-enhanced ultrasound to predict early lymph-node metastasis in breast cancer Peer-reviewed

Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yumiko Kudo, Mikiko Suzuki, Li Li, Yu Mori, Shoki Takahashi, Kei Takase

Japanese Journal of Radiology　37　(2)　145-153　2019/02/20

DOI： 10.1007/s11604-018-0792-6 　

ISSN： 1867-1071

eISSN： 1867-108X
膵切除後仮性動脈瘤の治療戦略膵頭十二指腸切除術術後出血の治療とその成績

森川孝則, 畠達夫, 伊関雅裕, 高舘達之, 有明恭平, 川口桂, 益田邦洋, 石田晶玄, 大塚英郎, 水間正道, 中川圭, 林洋毅, 元井冬彦, 亀井尚, 内藤剛, 高瀬圭, 海野倫明

日本腹部救急医学会雑誌　39　(2)　323-323　2019/02
Publisher: (一社)日本腹部救急医学会
ISSN： 1340-2242

eISSN： 1882-4781
側頭葉てんかんにおける乳頭体萎縮の意義

森下陽平, 麦倉俊司, 佐藤志帆, 明石敏昭, 高瀬圭

Japanese Journal of Radiology　37　(Suppl.)　8-8　2019/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
NETの局在診断 SACIテストとオクトレオスキャンの比較

井上麻美, 外山由貴, 佐藤友美, 柳垣聡, 村中美千帆, 前川由依, 齊藤美穂子, 高浪健太郎, 高瀬圭

Japanese Journal of Radiology　37　(Suppl.)　10-10　2019/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
慢性血栓塞栓性肺高血圧症の治療前後における肺野ヨードマップのヒストグラム解析

大田英揮, 高木英誠, 冨永循哉, 高瀬圭, 杉村宏一郎, 佐藤遙, 高木英誠

Japanese Journal of Radiology　37　(Suppl.)　3-3　2019/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
Pulmonary Lymphatic Perfusion Syndrome. International-journal Peer-reviewed

Hirano T, Fujino N, Takase K, Ota H, Tanaka R, Saito R, Suzuki A, Okutomo K, Sato T, Kageyama S, Tamada T, Sugiura H, Ichinose M

American journal of respiratory and critical care medicine　199　(4)　529-530　2019/02

DOI： 10.1164/rccm.201806-1125IM 　

ISSN： 1073-449X
Efficacy of 4'-[methyl-11C] thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal cancer: a pilot study. International-journal Peer-reviewed

Masatoshi Hotta, Ryogo Minamimoto, Kazuhiko Yamada, Kyoko Nohara, Daisuke Soma, Kazuhiko Nakajima, Jun Toyohara, Kei Takase

EJNMMI research　9　(1)　10-10　2019/01/30

DOI： 10.1186/s13550-019-0478-9 　

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BACKGROUND: 4'-[Methyl-11C] thiothymidine (4DST) has been introduced as a new cell proliferation imaging PET tracer that incorporates into DNA directly. The aim of this prospective study was to evaluate the efficacy of 4DST PET/CT for predicting responses to neoadjuvant therapy in patients with esophageal cancer comparing with FDG PET/CT. METHODS: Twenty-six patients who had pre- and post-therapeutic 4DST and FDG PET/CT and underwent esophagectomy following neoadjuvant therapy were used for the analysis. Based on pathological findings, patients were divided into two groups: non-responders and responders. The maximum standardized uptake value (SUVmax), metabolic tumor volume, total lesion glycolysis, and total lesion proliferation of the primary lesion were measured for FDG and 4DST PET. RESULTS: The pathological diagnosis revealed 16 responders and 10 non-responders. Non-responders showed significantly higher 4DST post-therapeutic SUVmax (postSUVmax) than responders, whereas FDG postSUVmax showed no statistically significant difference (non-responders vs. responders: 4DST, 6.7 vs. 3.3, p = 0.001; FDG, 6.1 vs. 4.5, p = 0.11). Responders showed a greater reduction in percentage changes of 4DST and FDG SUVmax (ΔSUVmax) from baseline to post-therapeutic PET (non-responders vs. responders: 4DST, - 2.9% vs. - 56.7%, p < 0.001; FDG, - 36.3% vs. - 72.6%, p < 0.001). In ROC analysis, ΔSUVmax and postSUVmax with 4DST provided great diagnostic performance for predicting responses (area under the curve: 4DST ΔSUVmax = 0.92, 4DST postSUVmax = 0.88). CONCLUSIONS: 4DST PET/CT has a great potential for predicting pathologic response to neoadjuvant therapy in patients with esophageal cancer; it may be slightly superior to that with FDG PET/CT.
Validating an Empirical Mathematical Model for Dynamic Contrast-enhanced MR Imaging of Hand and Wrist Synovitis in Rheumatoid Arthritis: Correlation of Model Parameters with Clinical Disease Activity Peer-reviewed

Ochi J, Mori N, Mori Y, Mugikura S, Hitachi S, Itoi E, Takase K

Magnetic Resonance in Medical Sciences　2019

DOI： 10.2463/mrms.mp.2019-0026 　

ISSN： 1880-2206
A multicenter trial of extracorporeal cardiac shock wave therapy for refractory angina pectoris: report of the highly advanced medical treatment in Japan. Peer-reviewed

Yoku Kikuchi, Kenta Ito, Tomohiko Shindo, Kiyotaka Hao, Takashi Shiroto, Yasuharu Matsumoto, Jun Takahashi, Takao Matsubara, Akira Yamada, Yukio Ozaki, Michiaki Hiroe, Kazuo Misumi, Hideki Ota, Kentaro Takanami, Tomomichi Hiraide, Kei Takase, Fumiya Tanji, Yasutake Tomata, Ichiro Tsuji, Hiroaki Shimokawa

Heart and vessels　34　(1)　104-113　2019/01

DOI： 10.1007/s00380-018-1215-4 　

ISSN： 0910-8327

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We have previously demonstrated that cardiac shock wave therapy (CSWT) effectively improves myocardial ischemia through coronary neovascularization both in a porcine model of chronic myocardial ischemia and in patients with refractory angina pectoris (AP). In this study, we further addressed the efficacy and safety of CSWT in a single-arm multicenter study approved as a highly advanced medical treatment by the Japanese Ministry of Health, Labour and Welfare. Fifty patients with refractory AP [mean age 70.9 ± 12.6 (SD) years, M/F 38/12] without the indications of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were enrolled in 4 institutes in Japan. Ischemic myocardial regions in the left ventricle (LV) were identified by drug-induced stress myocardial perfusion imaging (MPI). Shock waves (200 shots/spot at 0.09 mJ/mm2) were applied to 40-60 spots in the ischemic myocardium 3 times in the first week. The patients were followed up for 3 months thereafter. Forty-one patients underwent CSWT and completed the follow-up at 3 months. CSWT markedly improved weekly nitroglycerin use [from 3.5 (IQR 2 to 6) to 0 (IQR 0 to 1)] and the symptoms [Canadian Cardiovascular Society functional class score, from 2 (IQR 2 to 3) to 1 (IQR 1 to 2)] (both P < 0.001). CSWT also significantly improved 6-min walking distance (from 384 ± 91 to 435 ± 122 m, P < 0.05). There were no significant changes in LV ejection fraction evaluated by echocardiography and LV stroke volume evaluated by cardiac magnetic resonance imaging (from 56.3 ± 14.7 to 58.8 ± 12.8%, P = 0.10, and from 52.3 ± 17.4 to 55.6 ± 15.7 mL, P = 0.15, respectively). Percent myocardium ischemia assessed by drug-induced stress MPI tended to be improved only in the treated segments (from 16.0 ± 11.1 to 12.1 ± 16.2%, P = 0.06), although no change was noted in the whole LV. No procedural complications or adverse effects related to the CSWT were noted. These results of the multicenter trial further indicate that CSWT is a useful and safe non-invasive strategy for patients with refractory AP with no options of PCI or CABG.
Time to Face the Nightmare That Has Plagued Neurosurgeons for Years: Memory Impairment from Postsurgery Subcallosal Artery Infarction for Anterior Communicating Artery Aneurysms. International-journal Peer-reviewed

Mugikura S, Takahashi S, Takase K

World neurosurgery　121　280-281　2019/01

DOI： 10.1016/j.wneu.2018.08.224 　

ISSN： 1878-8750
Correlation between the native lung volume change and postoperative pulmonary function after single lung transplantation for lymphangioleiomyomatosis: Evaluation of lung volume by three-dimensional computed tomography volumetry. International-journal Peer-reviewed

Suzuki H, Oishi H, Noda M, Watanabe T, Matsuda Y, Tominaga J, Sado T, Sakurada A, Kurosawa H, Takase K, Okada Y

PloS one　14　(2)　e0210975　2019

DOI： 10.1371/journal.pone.0210975 　

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PURPOSE: Whereas native lung overinflation has been thought to happen in recipients of single lung transplantation for lymphangioleiomyomatosis because of its increased compliance, there is no study that has reported the details on the change of the native lung volume after single lung transplantation by three-dimensional computed tomography volumetry. The purpose of the present study was to evaluate the lung volume after single lung transplantation for lymphangioleiomyomatosis by three-dimensional computed tomography volumetry and investigate the correlation between the native lung volume change and postoperative pulmonary function. METHODS: We retrospectively reviewed the data of 17 patients who underwent single lung transplantation for lymphangioleiomyomatosis. We defined the ratio of the native lung volume to total lung volume (N/T ratio) as an indicator of overinflation of the native lung. In order to assess changes in the N/T ratio over time, we calculated the rate of change in the N/T ratio which is standardized by the N/T ratio at 1 year after single lung transplantation: rate of change in N/T ratio (%) = {(N/T ratio at a certain year)/(N/T ratio at 1 year)- 1}× 100. RESULTS: We investigated the correlations between the N/T ratio and the pulmonary function test parameters at 1 year and 5 years; however, there was no significant correlation between them. On the other hand, there was a significant negative correlation between the rate of change in the N/T ratio and that in forced expiratory volume in 1 second %predicted (%FEV1) at 5 years after single lung transplantation. CONCLUSION: The single lung transplantation recipients for lymphangioleiomyomatosis showed increased rate of change in the N/T ratio in the long-time course after lung transplantation with the decrease of %FEV1. We expect that these cases will probably cause the overinflation of the native lung in the future.
Influence of renal function and demographic data on intrarenal Doppler ultrasonography. International-journal Peer-reviewed

Michiaki Abe, Tetsuya Akaishi, Takashi Miki, Mika Miki, Yasuharu Funamizu, Kaori Araya, Kota Ishizawa, Shin Takayama, Kei Takase, Takaaki Abe, Tadashi Ishii, Sadayoshi Ito

PloS one　14　(8)　e0221244　2019

DOI： 10.1371/journal.pone.0221244 　

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Intrarenal Doppler ultrasonography is a non-invasive method to evaluate the renal blood flow in patients with renal arterial stenosis as well as chronic kidney diseases (CKD). Until recently, the relationship between ultrasonography findings and CKD stage has not been fully understood. Overall, 162 patients with CKD without apparent renal arterial stenosis were included in this study, and the pulsed-wave Doppler ultrasonography findings were evaluated in terms of the following parameters: peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) at the renal arterial trunk, hilum, segmental, and interlobar regions. Age showed a significant negative correlation with the estimated glomerular filtration rate (eGFR), kidney size, and aortic PSV. Additionally, age showed a significant positive correlation with RI in all 4 regions. The eGFR showed a positive correlation with the aortic PSV and kidney size, but a negative correlation with RI. Both age and eGFR were found to be independently associated with aortic blood flow. On the intrarenal ultrasound, EDV and RI showed stronger correlations with eGFR than PSV, suggesting that the former indices would be better markers of renal function. In particular, the interlobar EDV was found to be the best index that reflects renal function. Although the RI is also a good marker of renal function, it is confounded by age; thus, its utility would be weaker than that of the EDV. In conclusion, intrarenal pulsed-wave Doppler ultrasonography is a useful tool to estimate and evaluate the renal function; the interlobar EDV may be the best index to estimate the effective perfusion and filtration of the kidneys.
ソマトスタチン受容体シンチの生理的集積と偽陽性・偽陰性

鎌田裕基, 外山由貴, 齊藤美穂子, 高浪健太郎, 高瀬圭

核医学　55　(1)　38-38　2018/12
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
当院における塩化ラジウム(223Ra)の初期経験

太田瑛梨, 鎌田裕基, 外山由貴, 齋藤美穂子, 高浪健太郎, 高瀬圭, 高橋紀善, 石川陽二郎, 山本貴也, 梅澤玲, 松下晴雄, 神宮啓一

核医学　55　(1)　37-37　2018/12
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
FDG-PETで高集積を呈した稀な腹壁病変の一例

樋口慧, 外山由貴, 前川由衣, 齋藤美穂子, 高浪健太郎, 高瀬圭, 植松智海, 佐藤聡子

核医学　55　(1)　41-41　2018/12
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
先端巨大症合併膝関節症に対して下垂体手術がもたらす効果膝関節MRIを用いた22症例の解析

祢津昌広, 工藤正孝, 森本玲, 手塚雄太, 小野美澄, 尾股慧, 五十嵐康宏, 常陸真, 高瀬圭, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　94　(3)　873-873　2018/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
アルドステロン産生腺腫合併例における腎組織障害

手塚雄太, 尾形博子, 森本玲, 工藤正孝, 五十嵐康宏, 高瀬圭, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　94　(4)　1572-1572　2018/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
当科における転移性副腎腫瘍に対する診療実績

工藤正孝, 手塚雄太, 森本玲, 祢津昌広, 五十嵐康宏, 清治和将, 高瀬圭, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　94　(4)　1597-1597　2018/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
最新半導体PETにおける上腹部病変への呼吸同期の有用性

外山由貴, 高浪健太郎, 太田瑛梨, 加賀谷由里子, 前川由依, 齊藤美穂子, 高瀬圭

核医学　55　(Suppl.)　S208-S208　2018/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
最新型半導体PETと従来型PETにおける下垂体FDG集積と視認性の比較検討

加賀谷由里子, 外山由貴, 太田瑛梨, 前川由依, 斎藤美穂子, 高浪健太郎, 高瀬圭

核医学　55　(Suppl.)　S208-S208　2018/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Traumatic midline subarachnoid hemorrhage on initial computed tomography as a marker of severe diffuse axonal injury. International-journal Peer-reviewed

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi, Kei Takase

Journal of neurosurgery　129　(5)　1317-1324　2018/11/01

DOI： 10.3171/2017.6.JNS17466 　

ISSN： 0022-3085

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OBJECTIVEThe objective of this study was to test the hypothesis that midline (interhemispheric or perimesencephalic) traumatic subarachnoid hemorrhage (tSAH) on initial CT may implicate the same shearing mechanism that underlies severe diffuse axonal injury (DAI).METHODSThe authors enrolled 270 consecutive patients (mean age [± SD] 43 ± 23.3 years) with a history of head trauma who had undergone initial CT within 24 hours and brain MRI within 30 days. Six initial CT findings, including intraventricular hemorrhage (IVH) and tSAH, were used as candidate predictors of DAI. The presence of tSAH was determined at the cerebral convexities, sylvian fissures, sylvian vallecula, cerebellar folia, interhemispheric fissure, and perimesencephalic cisterns. Following MRI, patients were divided into negative and positive DAI groups, and were assigned to a DAI stage: 1) stage 0, negative DAI; 2) stage 1, DAI in lobar white matter or cerebellum; 3) stage 2, DAI involving the corpus callosum; and 4) stage 3, DAI involving the brainstem. Glasgow Outcome Scale-Extended (GOSE) scores were obtained in 232 patients.RESULTSOf 270 patients, 77 (28.5%) had DAI; tSAH and IVH were independently associated with DAI (p < 0.05). Of tSAH locations, midline tSAH was independently associated with both overall DAI and DAI stage 2 or 3 (severe DAI; p < 0.05). The midline tSAH on initial CT had sensitivity of 60.8%, specificity of 81.7%, and positive and negative predictive values of 43.7% and 89.9%, respectively, for severe DAI. When adjusted for admission Glasgow Coma Score, the midline tSAH independently predicted poor GOSE score at both hospital discharge and after 6 months.CONCLUSIONSMidline tSAH could implicate the same shearing mechanism that underlies severe DAI, for which midline tSAH on initial CT is a probable surrogate.
Left Ventricular T1 Mapping during Chemotherapy-Radiation Therapy: Serial Assessment of Participants with Esophageal Cancer. International-journal Peer-reviewed

Takagi H, Ota H, Umezawa R, Kimura T, Kadoya N, Higuchi S, Sun W, Nakajima Y, Saito M, Komori Y, Jingu K, Takase K

Radiology　289　(2)　347-354　2018/11

DOI： 10.1148/radiol.2018172076 　

ISSN： 0033-8419

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Purpose To assess changes in left ventricular function and tissue composition by using MRI after chemotherapy-radiation therapy in participants with esophageal cancer. Materials and Methods Between January 2013 and April 2015, this prospective study enrolled 24 participants (42% women; mean age, 63 years; range, 49-73 years) scheduled for chemotherapy-radiation therapy. 3.0-T MRI examinations were performed before, at 0.5 year, and at 1.5 years after chemotherapy-radiation therapy. Myocardial native T1, postcontrast T1, and extracellular volume were measured in basal septum (as irradiated areas) and apical lateral wall (as nonirradiated areas). Left ventricular function, prevalence of late gadolinium enhancement, and T1 and extracellular volume values were compared over the follow-up period by using Friedman or Cochran Q tests, followed by Dunn test. Results In 14 participants who were followed up for 1.5 years, native T1 and extracellular volume in the septum were elevated at 0.5 year compared with baseline (1183 msec ± 46 [standard deviation] vs 1257 msec ± 35; 26% ± 3 vs 32% ± 3; adjusted P < .01 for both), but not in the lateral wall. Left ventricular stroke volume index and late gadolinium enhancement changed at 1.5 years compared with baseline (41 mL/m2 ± 11 vs 36 mL/m2 ± 9; P = .046; 7% [one of 14] vs 78% [11 of 14]; P < .01). Other measures of left ventricular function did not change during the follow-up period (P > .10 for all). Conclusion Native T1 and extracellular volume could detect early changes in myocardium at 0.5 year after chemotherapy-radiation therapy, whereas left ventricular stroke volume index and late gadolinium enhancement showed abnormality at 1.5 years. © RSNA, 2018 Online supplemental material is available for this article.
Effects of surgical treatment for acromegaly on knee MRI structural features. Peer-reviewed

Masahiro Nezu, Masataka Kudo, Ryo Morimoto, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Yasuhiro Igarashi, Shin Hitachi, Kei Takase, Sadayoshi Ito, Fumitoshi Satoh

Endocrine journal　65　(10)　991-999　2018/10/29

DOI： 10.1507/endocrj.EJ18-0108 　

ISSN： 0918-8959

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Acromegalic arthropathy is a common complication of acromegaly and harms the quality of life of the patients even after acromegaly is in long-term remission. A recent study demonstrated by knee MRI the characteristic structural features of acromegalic arthropathy. However, the effects of treatment for acromegaly on such structural features are almost unknown. This study was undertaken to analyze the effects of transsphenoidal surgery (TSS) on acromegalic arthropathy and elucidate whether knee MRI findings are reversible or irreversible. We analyzed 22 patients with acromegaly (63.7% females, median age 58 years) by knee MRI at diagnosis. Out of these 22 patients, 16 who underwent TSS (68.9% female, median age 58 years) were also subjected to knee MRI 2 months after TSS. As for X-ray undetectable findings, MRI detected synovial thickening, bone marrow lesion, ligament injury and meniscus injury in 22.7%, 22.7%, 4.7% and 59.1% of the patients, respectively. With respect to the 16 patients who underwent TSS, clinical and structural improvements were observed respectively in 100%, 66.7% and 66.7% of the patients who showed knee joint pain, synovial thickening and bone marrow lesion before TSS. However, no patient showed structural improvement of meniscus injury after TSS. In acromegalic arthropathy, synovial thickening and bone marrow lesions are reversible while meniscus injury is irreversible. Because all those findings are associated with the exacerbation of arthropathy, they may be therapeutic targets for preventing the progression of arthropathy by endocrinological and orthopedic intervention.
抗血栓療法を要する原発性アルドステロン症の臨床的特徴の解明

工藤正孝, 森本玲, 手塚雄太, 尾股慧, 白鳥ベアタ, 五十嵐康弘, 清治和将, 高瀬圭, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　41回　OC05-06　2018/09
Publisher: (NPO)日本高血圧学会
Rapid Development of New Aneurysms in the Adjacent Pancreatic Arcade Arteries after Urgent Embolization of Pancreaticoduodenal Artery Aneurysms in Cases with Celiac Stenosis. Peer-reviewed

Hasegawa T, Seiji K, Ota H, Matsuura T, Satani N, Sato T, Takase K

Journal of vascular and interventional radiology : JVIR　29　(9)　1306-1308.e2　2018/09
Publisher: Elsevier BV
DOI： 10.1016/j.jvir.2018.04.003 　

ISSN： 1051-0443
[Imaging Diagnosis and Interventional Radiology for Thoracic Surgery]. Peer-reviewed

Takase K

Kyobu geka. The Japanese journal of thoracic surgery　71　(10)　747-754　2018/09

ISSN： 0021-5252
褐色細胞腫患者における心筋T1 mappingを用いたカテコラミン心筋障害の評価

樋口慧, 大田英揮, 手塚雄太, 祢津昌広, 森本玲, 高瀬圭

日独医報　63　(1)　81-81　2018/07
Publisher: バイエル薬品(株)
ISSN： 0912-0351
Suppressive effect of pitavastatin on aortic arch dilatation in acute stanford type B aortic dissection: analysis of STANP trial

Naoki Masaki, Kiichiro Kumagai, Konosuke Sasaki, Satoshi Matsuo, Naotaka Motoyoshi, Osamu Adachi, Masatoshi Akiyama, Shunsuke Kawamoto, Koichi Tabayashi, Yoshikatsu Saiki, Yumi Sugawara, Hidenobu Takagi, Satoshi Higuchi, Hideki Ota, Kei Takase, Kazuyuki Daitoku, Ikuo Fukuda, Hiroyuki Itaya, Suguru Watanabe, Seijiro Yoshida, Masaki Hata, Norio Tada, Koichi Nagaya, Katsuhiko Oda, Kei Sakuma, Tetsuo Watanabe

General Thoracic and Cardiovascular Surgery　66　334-343　2018/06/01

DOI： 10.1007/s11748-018-0916-z 　

ISSN： 1863-6705
Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy Peer-reviewed

Maiko Kozumi, Hideki Ota, Takaya Yamamoto, Rei Umezawa, Haruo Matsushita, Yojiro Ishikawa, Noriyoshi Takahashi, Tomonori Matsuura, Kei Takase, Keiichi Jingu

European Radiology　28　(10)　1-10　2018/05/03
Publisher: Springer Verlag
DOI： 10.1007/s00330-018-5439-6 　

ISSN： 1432-1084 0938-7994
Treatment Effect of Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension Quantified by Automatic Comparative Imaging in Computed Tomography Pulmonary Angiography Peer-reviewed

Zhiwei Zhai, Hideki Ota, Marius Staring, Jan Stolk, Koichiro Sugimura, Kei Takase, Berend C. Stoel

Investigative Radiology　53　(5)　286-292　2018/05/01
Publisher: Lippincott Williams and Wilkins
DOI： 10.1097/RLI.0000000000000441 　

ISSN： 1536-0210 0020-9996
Relationship Between Perforator Infarction and Patient Outcomes After Surgical Treatment of Ruptured Anterior Communicating Artery Aneurysms. Peer-reviewed

Mugikura S, Fujimura M, Takahashi S, Takase K

World neurosurgery　113　390-391　2018/05

DOI： 10.1016/j.wneu.2018.01.161 　

ISSN： 1878-8750
Relationship between ischemic injury and patient outcomes after surgical or endovascular treatment of ruptured anterior communicating artery aneurysms

S. Mugikura, S. Takahashi, K. Takase

American Journal of Neuroradiology　39　2018/04/01

DOI： 10.3174/ajnr.A5564 　

ISSN： 0195-6108
Renovascular hypertension associated with JAK2 V617F positive myeloproliferative neoplasms treated with angioplasty: 2 cases and literature review. International-journal Peer-reviewed

Eikan Mishima, Takehiro Suzuki, Yoichi Takeuchi, Kazumasa Seiji, Noriko Fukuhara, Kei Takase, Hideo Harigae, Takaaki Abe, Sadayoshi Ito

Journal of clinical hypertension (Greenwich, Conn.)　20　(4)　798-804　2018/04

DOI： 10.1111/jch.13257 　

ISSN： 1524-6175

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Myeloproliferative neoplasms (MPNs) with Janus kinase 2 (JAK2) mutation are associated with a high risk for occlusive vascular diseases. We report 2 cases of renovascular hypertension associated with JAK2 V617F mutation-positive MPNs and provide a literature review. In Case 1, a 63-year-old woman had resistant hypertension, massive proteinuria, and erythrocytosis. Evaluations revealed right renal artery stenosis causing renovascular hypertension and polycythemia vera with JAK2 V617F mutation. Renin-angiotensin system inhibitors and subsequent angioplasty controlled the blood pressure and the proteinuria resolved. In Case 2, a 74-year-old woman had resistant hypertension and thrombocytosis. Evaluations confirmed left renal artery stenosis and essential thrombocythemia with JAK2 V617F. Angioplasty cured the hypertension. A literature review of 18 cases revealed the following as the most common characteristics of MPN-associated renovascular hypertension: manifests primarily in women; is associated with untreated polycythemia vera and essential thrombocythemia, concomitant leukocytosis, and JAK2 mutation positivity; and is responsive to angioplasty. This report demonstrates that JAK2 mutation-positive MPNs are a less common but important underlying cause of adult renovascular hypertension.
Anthracycline系による治療を受けた癌患者の管理における心臓MRIの有用性腫瘍循環器学の進歩(Usefulness of Cardiac MRI in the Management of Cancer Patients Treated with Anthracyclines: Progress in Cardiooncology)

照井洋輔, 杉村宏一郎, 大田英揮, 佐藤遥, 後岡広太郎, 建部俊介, 青木竜男, 山本沙織, 神津克也, 紺野亮, 高瀬圭, 下川宏明

日本循環器学会学術集会抄録集　82回　OJ02-4　2018/03
Publisher: (一社)日本循環器学会
右鼠径部-大陰唇の膨隆を呈し、臨床的に鼠径ヘルニアや水腫が疑われた小児症例

樋口慧, 北見昌広, 齋藤美穂子, 高瀬圭, 西功太郎, 袴塚崇, 古田明美

Japanese Journal of Radiology　36　(Suppl.)　14-14　2018/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
縦隔の悪性Solitary Fibrous Tumorの1例

村中美千帆, 冨永循哉, 高瀬圭, 桜田晃, 齊藤涼子

Japanese Journal of Radiology　36　(Suppl.)　16-16　2018/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
肺癌SRT症例の治療前PETにおけるテクスチャ解析の有用性

武田一也, 松下晴雄, 久保園正樹, 田邊隆哉, 石川陽二郎, 山本貴也, 古積麻衣子, 高橋紀善, 片桐佑, 田坂俊, 福井勝哉, 鈴木友, 角谷倫之, 伊藤謙吾, 千葉瑞己, 神宮啓一, 武田賢, 土橋卓, 高浪健太郎, 高瀬圭, 瀧靖之

Japanese Journal of Radiology　36　11-11　2018/02
Usefulness of the S–O clip for gastric endoscopic submucosal dissection (with video) Peer-reviewed

Rintaro Hashimoto, Dai Hirasawa, Tomoyuki Iwaki, Hajime Yamaoka, Kousuke Nihei, Ippei Tanaka, Akimichi Chonan, Kei Takase

Surgical Endoscopy and Other Interventional Techniques　32　(2)　908-914　2018/02/01
Publisher: Springer New York LLC
DOI： 10.1007/s00464-017-5765-9 　

ISSN： 1432-2218 0930-2794
Subcallosal and Heubner artery infarcts following surgical repair of an anterior communicating artery aneurysm: a causal relationship with postoperative amnesia and long-term outcome Peer-reviewed

Shunji Mugikura, Hirokazu Kikuchi, Miki Fujimura, Etsuro Mori, Shoki Takahashi, Kei Takase

Japanese Journal of Radiology　36　(2)　81-89　2018/02/01
Publisher: Springer Tokyo
DOI： 10.1007/s11604-017-0703-2 　

ISSN： 1867-108X 1867-1071
Coronary Adventitial and Perivascular Adipose Tissue Inflammation in Patients With Vasospastic Angina. International-journal Peer-reviewed

Kazuma Ohyama, Yasuharu Matsumoto, Kentaro Takanami, Hideki Ota, Kensuke Nishimiya, Jun Sugisawa, Satoshi Tsuchiya, Hirokazu Amamizu, Hironori Uzuka, Akira Suda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Hiroaki Shimokawa

Journal of the American College of Cardiology　71　(4)　414-425　2018/01/30

DOI： 10.1016/j.jacc.2017.11.046 　

ISSN： 0735-1097

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BACKGROUND: Recent studies suggested that perivascular components, such as perivascular adipose tissue (PVAT) and adventitial vasa vasorum (VV), play an important role as a source of various inflammatory mediators in cardiovascular disease. OBJECTIVES: The authors tested their hypothesis that coronary artery spasm is associated with perivascular inflammation in patients with vasospastic angina (VSA) using 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). METHODS: This study prospectively examined 27 consecutive VSA patients with acetylcholine-induced diffuse spasm in the left anterior descending artery (LAD) and 13 subjects with suspected angina but without organic coronary lesions or coronary spasm. Using CT coronary angiography and electrocardiogram-gated 18F-FDG PET/CT, coronary PVAT volume and coronary perivascular FDG uptake in the LAD were examined. In addition, adventitial VV formation in the LAD was examined with optical coherence tomography, and Rho-kinase activity was measured in circulating leukocytes. RESULTS: Patient characteristics were comparable between the 2 groups. CT coronary angiography and ECG-gated 18F-FDG PET/CT showed that coronary PVAT volume and coronary perivascular FDG uptake significantly increased in the VSA group compared with the non-VSA group. Furthermore, optical coherence tomography showed that adventitial VV formation significantly increased in the VSA group compared with the non-VSA group, as did Rho-kinase activity. Importantly, during the follow-up period with medical treatment, both coronary perivascular FDG uptake and Rho-kinase activity significantly decreased in the VSA group. CONCLUSIONS: These results provide the first evidence that coronary spasm is associated with inflammation of coronary adventitia and PVAT, where 18F-FDG PET/CT could be useful for disease activity assessment. (Morphological and Functional Change of Coronary Perivascular Adipose Tissue in Vasospastic Angina [ADIPO-VSA Trial]; UMIN000016675).
Four-Dimensional Flow Magnetic Resonance Imaging for Cardiovascular Imaging: from Basic Concept to Clinical Application Peer-reviewed

Hideki Ota, Satoshi Higuchi, Wenyu Sun, Takuya Ueda, Kei Takase, Hajime Tamura

Cardiovascular Imaging Asia　2　(2)　85　2018
Publisher: Asian Society of Cardiovascular Imaging
DOI： 10.22468/cvia.2018.00045 　

ISSN： 2508-707X
Computational Fluid Dynamics Modeling in Aortic Diseases Peer-reviewed

Takuya Ueda, Hiroshi Suito, Hideki Ota, Kei Takase

Cardiovascular Imaging Asia　2　(2)　58　2018
Publisher: Asian Society of Cardiovascular Imaging
DOI： 10.22468/cvia.2018.00073 　

ISSN： 2508-707X
Image quality and radiation dose of low-tube-voltage CT with reduced contrast media for right adrenal vein imaging. International-journal Peer-reviewed

Yuki Takahashi, Hideki Ota, Kensuke Omura, Yutaka Dendo, Katharina Otani, Tomonori Matsuura, Masahiro Kitami, Kazumasa Seiji, Yuta Tezuka, Masahiro Nezu, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

European journal of radiology　98　150-157　2018/01

DOI： 10.1016/j.ejrad.2017.11.017 　

ISSN： 0720-048X

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OBJECTIVES: To compare image quality and radiation dose of right adrenal vein (RAV) imaging computed tomography (CT) among conventional, low kV, and low kV with reduced contrast medium protocols. METHODS: One-hundred-and-twenty patients undergoing adrenal CT were randomly assigned to one of three protocols: contrast dose of 600mgI/kg at 120-kV tube voltage setting (600-120 group), 600mgI/kg at 80kV (600-80 group), and 360mgI/kg at 80kV (360-80 group). Iterative reconstruction was used for 80-kV groups. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the RAV and size-specific dose estimates (SSDE) were measured. Three radiologists evaluated 4-point visualisation scores of RAV by consensus reading. RESULTS: The RAV detectability was 95%, 97.2%, and 97.3% for 600-120, 600-80, and 360-80 groups, respectively (p=1.000). Visualisation scores were not significantly different among the groups (p=0.152). There were no significant differences in CNR or SNR between the 600-120 and 360-80 groups. SSDE of the 360-80 group was significantly lower than that of the 600-120 group (5.86mGy±1.44 vs. 7.27mGy±1.81, p<0.001). CONCLUSIONS: 80-kV scans with 360 mgI/kg contrast media showed comparable detectability of RAV to conventional scans, while reducing 19% of SSDE.
Influence of Uncertain Anticipation on Brain Responses to Aversive Rectal Distension in Patients With Irritable Bowel Syndrome Peer-reviewed

Michiko Kano, Tomohiko Muratsubaki, Joe Morishita, Keiji Kono, Shunji Mugikura, Kei Takase, Huynh Giao Ly, Patrick Dupont, Lukas Van Oudenhove, Shin Fukudo

PSYCHOSOMATIC MEDICINE　79　(9)　988-999　2017/11

DOI： 10.1097/PSY.0000000000000484 　

ISSN： 0033-3174

eISSN： 1534-7796
Fear of linear gadolinium-based contrast agents and the Japanese radiologist's choice Peer-reviewed

Shunji Mugikura, Kei Takase

JAPANESE JOURNAL OF RADIOLOGY　35　(11)　695-696　2017/11

DOI： 10.1007/s11604-017-0682-3 　

ISSN： 1867-1071

eISSN： 1867-108X
The re-emerging importance of radiologic-pathologic correlation in reaching the pathology diagnosis Peer-reviewed

Monica Sze Man Chan, Ryoko Saito, Kei Takase, Yasuhiro Nakamura, Hironobu Sasano

PATHOLOGY INTERNATIONAL　67　(11)　537-538　2017/11

DOI： 10.1111/pin.12599 　

ISSN： 1320-5463

eISSN： 1440-1827
Clinical utility of texture analysis of 18F-FDG PET/CT in patients with Stage I lung cancer treated with stereotactic body radiotherapy Peer-reviewed

Kazuya Takeda, Kentaro Takanami, Yuko Shirata, Takaya Yamamoto, Noriyoshi Takahashi, Kengo Ito, Kei Takase, Keiichi Jingu

JOURNAL OF RADIATION RESEARCH　58　(6)　862-869　2017/11

DOI： 10.1093/jrr/rrx050 　

ISSN： 0449-3060

eISSN： 1349-9157
無症候性原発性副甲状腺機能亢進症の一例

手塚雄太, 森本玲, 祢津昌広, 五十嵐康宏, 工藤正孝, 高瀬圭, 中島範昭, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　93　(2)　565-565　2017/10
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
Selective embolization therapy for intrarenal artery stenosis causing renovascular hypertension: Efficacy and follow-up renal imaging Peer-reviewed

Eikan Mishima, Takehiro Suzuki, Kazumasa Seiji, Yasutoshi Akiyama, Hideki Ota, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito

JOURNAL OF CLINICAL HYPERTENSION　19　(10)　1028-1031　2017/10

DOI： 10.1111/jch.13040 　

ISSN： 1524-6175

eISSN： 1751-7176
Native T1値と細胞外容積分画を用いた放射線心筋障害の評価

高木英誠, 大田英揮, 梅沢玲, 神宮啓一, 高瀬圭

日独医報　62　(1)　82-82　2017/09
Publisher: バイエル薬品(株)
ISSN： 0912-0351
Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome Peer-reviewed

Michiko Kano, Tomohiko Muratsubaki, Lukas Van Oudenhove, Joe Morishita, Makoto Yoshizawa, Keiji Kohno, Mao Yagihashi, Yukari Tanaka, Shunji Mugikura, Patrick Dupont, Huynh Giao Ly, Kei Takase, Motoyori Kanazawa, Shin Fukudo

SCIENTIFIC REPORTS　7　(1)　12425　2017/09

DOI： 10.1038/s41598-017-09635-x 　

ISSN： 2045-2322
心臓核医学のessence

外山由貴, 高浪健太郎, 太田瑛梨, 齊藤美穂子, 高瀬圭

日本医学放射線学会秋季臨床大会抄録集　53回　S505-S505　2017/08
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Ischemic White Matter Lesions Associated With Medullary Arteries: Classification of MRI Findings Based on the Anatomic Arterial Distributions Peer-reviewed

Toshiaki Akashi, Shoki Takahashi, Shunji Mugikura, Shiho Sato, Takaki Murata, Atsushi Umetsu, Kei Takase

AMERICAN JOURNAL OF ROENTGENOLOGY　209　(3)　W160-W168　2017/08

DOI： 10.2214/AJR.16.17231 　

ISSN： 0361-803X

eISSN： 1546-3141
For Whom Should We Write a Radiology Report, an Attending Physician or a Patient? Peer-reviewed

Shunji Mugikura, Keisei Fujimori, Kei Takase

AMERICAN JOURNAL OF ROENTGENOLOGY　209　(3)　W199-W199　2017/08

DOI： 10.2214/AJR.17.18150 　

ISSN： 0361-803X

eISSN： 1546-3141
Further Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan. Peer-reviewed

Mugikura S, Fujimura M, Takahashi S, Takase K

Radiology　284　(1)　301-303　2017/07

DOI： 10.1148/radiol.2017170252 　

ISSN： 0033-8419
二次性高血圧を見逃さない原発性アルドステロン症診断治療のUpdate

佐藤文俊, 森本玲, 手塚雄太, 尾股慧, 祢津昌広, 小野美澄, 岩倉芳倫, 五十嵐康宏, 工藤正孝, 高瀬圭, 笹野公伸, 伊藤貞嘉

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　6回　103-103　2017/05
Publisher: (NPO)日本高血圧学会
副腎静脈サンプリングにて片側副腎摘除の適応と判定したが、最終的に薬物療法での加療を選択された症例についての報告

工藤正孝, 森本玲, 岩倉芳倫, 小野美澄, 手塚雄太, 祢津昌広, 五十嵐康宏, 清治和将, 高瀬圭, 伊藤貞嘉, 佐藤文俊

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　6回　156-156　2017/05
Publisher: (NPO)日本高血圧学会
新しいIVRの薬事承認医師主導医療機器治験非臨床試験、PMDA相談から治験完了までの道のり

高瀬圭, 清治和将, 森本玲, 佐藤文俊, 木下知, 伊藤貞嘉

IVR: Interventional Radiology　32　(Suppl.)　143-143　2017/04
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520

eISSN： 2185-6451
生体肝移植後の肝静脈血栓閉塞に対し、バルーン拡張と経カテーテルウロキナーゼ投与が奏功した一例

円城寺康宏, 大田英揮, 清治和将, 高瀬圭, 横沢友樹, 中西史, 宮城重人

IVR: Interventional Radiology　32　(Suppl.)　286-286　2017/04
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520

eISSN： 2185-6451
Coil embolization of left ventricular outflow tract pseudoaneurysms: techniques and 5-year results Peer-reviewed

Hideki Ota, Yoshiaki Morita, Yoshikatsu Saiki, Kei Takase

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY　24　(4)　631-633　2017/04

DOI： 10.1093/icvts/ivw394 　

ISSN： 1569-9293

eISSN： 1569-9285
【Q&Aでおさえるvascular imaging最重要ポイント】腹部線維筋性異形成(FMD)の本態、臨床像、特徴的な画像について教えてください

長谷川哲也, 津田雅視, 高瀬圭

臨床画像　33　(3)　348-349　2017/03
Publisher: (株)メジカルビュー社
ISSN： 0911-1069
早期治療にて日和見感染症を管理し得たCushing病の一例

手塚雄太, 森本玲, 工藤正孝, 祢津昌広, 小野美澄, 五十嵐康宏, 高瀬圭, 井下尚子, 山田正三, 伊藤貞嘉, 佐藤文俊

ACTH RELATED PEPTIDES　28　8-10　2017/03
Publisher: 間脳・下垂体・副腎系研究会
ISSN： 1340-4512

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症例は33歳男性で、31歳時より体重増加、体型変化を自覚した。満月様顔貌を認め、ACTH 54.0pgmL、Cortisol 26.9μg/dLと高値であり、ACTH依存性Cushing症候群の精査加療目的に当科紹介に至った。Cushing病の可能性について精査を進めていたが、精査中の入院第8病日に38℃台の発熱が出現し、CT検査で多発性肺炎が確認された。CRP、βDグルカンの軽度上昇を認め、多発する肺野病変からは、高コルチゾル血症を背景としたニューモシスチス肺炎などの日和見感染症が原因と考え、抗菌薬、抗真菌薬、抗ウイルス薬による治療を速やかに開始した。肺炎軽快後に行った全身の画像検査では下垂体以外に腫瘍性病変を認めず、トルコ鞍左上方の造影不領域の指摘、CRH負荷への反応性などから、総合的にCushing病と診断した。感染症を合併した背景から早期治療が必要と判断し、降圧薬を4剤へ増量、経鼻的持続陽圧呼吸療法導入にて高血圧症、睡眠時無呼吸症候群を管理した上で下垂体手術を行った後、初診時より3ヵ月後に経蝶形骨洞下垂体手術を施行した。術中、止血操作難渋し、下垂体腫瘍摘除は困難であった。術後、内分泌学的評価は不変であり、MRIにてトルコ鞍に残存病変が確認され、初診から約8ヵ月後に経蝶形骨洞下垂体手術を施行した。海綿静脈洞への明らかな浸潤はみられず、腫瘍部及び腫瘍内側の正常下垂体を十分に含む形で全摘された。摘出検体の所見より、densely type ACTH産生腺腫(Ki67標識率2.5%)と診断された。術後、MRI上は残存病変を認めず、ACTH、コルチゾル分泌も低下した。
Anderson-Fabry病の患者における心臓病変に対する新たな診断戦略(Novel Diagnostic Strategy for Cardiac Involvement in Patients with Anderson-Fabry Disease)

山本沙織, 杉村宏一郎, 鈴木秀明, 建部俊介, 青木竜男, 矢尾板信裕, 佐藤遥, 神津克也, 大田英揮, 高浪健太郎, 高瀬圭, 佐藤公雄, 下川宏明

日本循環器学会学術集会抄録集　81回　OJ-053　2017/03
Publisher: (一社)日本循環器学会
Quantitative Analysis of Contrast-Enhanced Ultrasound Imaging in Invasive Breast Cancer: A Novel Technique to Obtain Histopathologic Information of Microvessel Density Peer-reviewed

Naoko Mori, Shunji Mugikura, Shoki Takahashi, Koichi Ito, Chiaki Takasawa, Li Li, Minoru Miyashita, Atsuko Kasajima, Yu Mori, Takanori Ishida, Tetsuya Kodama, Kei Takase

Ultrasound in Medicine and Biology　43　(3)　607-614　2017/03/01

DOI： 10.1016/j.ultrasmedbio.2016.11.009 　

ISSN： 0301-5629

eISSN： 1879-291X
Anatomical Variations of the Right Adrenal Vein Concordance Between Multidetector Computed Tomography and Catheter Venography Peer-reviewed

Kensuke Omura, Hideki Ota, Yuuki Takahashi, Tomonori Matsuura, Kazumasa Seiji, Yoichi Arai, Ryo Morimoto, Fumitoshi Satoh, Kei Takase

HYPERTENSION　69　(3)　428-+　2017/03

DOI： 10.1161/HYPERTENSIONAHA.116.08375 　

ISSN： 0194-911X

eISSN： 1524-4563
数年を経て確定診断に至った骨原発悪性リンパ腫の3例

木下知, 常陸真, 榊原宏幸, 森下陽平, 高橋祐輝, 野村脩子, 加賀谷由里子, 長谷川哲也, 佐藤嘉尚, 佐藤友美, 嶋内亜希子, 森菜緒子, 松浦智徳, 大田英揮, 北見昌広, 冨永循哉, 清治和将, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　1-1　2017/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
肝腫瘍への定位照射を目的としたCTガイド下金マーカー留置術における合併症の検討

高橋祐輝, 松浦智徳, 榊原宏幸, 森下陽平, 加賀谷由里子, 野村脩子, 木下知, 長谷川哲也, 佐藤嘉尚, 嶋内亜希子, 森菜緒子, 大田英揮, 常陸真, 北見昌広, 冨永循哉, 清治和将, 高瀬圭, 神宮啓一, 小川芳弘

Japanese Journal of Radiology　35　(Suppl.)　2-2　2017/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
自然縮小した胸腺腫の1例

大山翼, 袴塚崇, 榊原宏幸, 森下陽平, 伊藤幸, 高橋祐輝, 野村脩子, 大村健介, 前川由衣, 加賀谷由里子, 長谷川哲也, 木下知, 佐藤嘉尚, 外山由貴, 冨永循哉, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　8-8　2017/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
冠状動脈-肺動脈瘻に合併した動脈瘤に対する塞栓術の1例

榊原宏幸, 大田英揮, 伊藤幸, 森下陽平, 高橋祐輝, 大村健介, 野村脩子, 加賀谷由里子, 前川由依, 木下知, 長谷川哲也, 佐藤嘉尚, 外山由貴, 佐藤友美, 嶋内亜希子, 森菜緒子, 松浦智徳, 北見昌広, 常陸真, 齊藤美穂子, 冨永循哉, 清治和将, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　8-8　2017/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
胆嚢悪性リンパ腫の1例

森下陽平, 長谷川哲也, 伊藤幸, 榊原宏幸, 高橋祐輝, 大村健介, 野村脩子, 加賀谷由里子, 前川由依, 木下知, 佐藤嘉尚, 外山由貴, 佐藤友美, 嶋内亜希子, 森菜緒子, 松浦智徳, 大田英揮, 北見昌広, 常陸真, 齊藤美穂子, 冨永循哉, 清治和将, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　10-10　2017/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
123I-MIBG心筋シンチグラフィと123I-FP-CIT SPECTを用いたLewy小体病とその類縁疾患の鑑別方法

外山由貴, 高浪健太郎, 森下陽平, 高瀬圭

臨床放射線　62　(1)　189-198　2017/01
Publisher: 金原出版(株)
ISSN： 0009-9252

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Lewy小体病は、その他パーキンソニズムを呈する神経変性疾患やアルツハイマー病などと区別されるが、その鑑別は難しい。鑑別に当っては画像診断の果たす役割は大きく、その中でも核医学分野の機能画像診断は有用である。123I-FP-CIT SPECTと123I-MIBG心筋シンチグラフィーを組み合わせることで、Lewy小体病の診断精度が上がるだけでなく、その類縁疾患などを診断する助けになる。その二つの検査を使った鑑別法を「4分割法」とし、理論と運用法を紹介した。
Endovascular Treatment of Hepatic Artery Pseudoaneurysm after Pancreaticoduodenectomy: Risk Factors Associated with Mortality and Complications Peer-reviewed

Tetsuya Hasegawa, Hideki Ota, Tomonori Matsuura, Kazumasa Seiji, Shunji Mugikura, Fuyuhiko Motoi, Michiaki Unno, Kei Takase

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　28　(1)　50-59　2017/01

DOI： 10.1016/j.jvir.2016.04.004 　

ISSN： 1051-0443

eISSN： 1535-7732
Focal Reduction in Cardiac I-123-Metaiodobenzylguanidine Uptake in Patients With Anderson-Fabry Disease Peer-reviewed

Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Shunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Haruka Sato, Katuya Kozu, Hideki Ota, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

CIRCULATION JOURNAL　80　(12)　2550-+　2016/12

DOI： 10.1253/circj.CJ-16-0690 　

ISSN： 1346-9843

eISSN： 1347-4820
重症高Ca血症の是正に難渋した原発性副甲状腺機能亢進症の一例

手塚雄太, 森本玲, 小野美澄, 岩倉芳倫, 工藤正孝, 祢津昌広, 尾股慧, 五十嵐康宏, 中島範昭, 高瀬圭, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　92　(2)　507-507　2016/10
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
透析中の血圧管理に難渋した副腎内傍神経節腫合併血液透析症例

手塚雄太, 森本玲, 秋保真穂, 藤倉恵美, 祢津昌広, 小野美澄, 五十嵐康宏, 工藤正孝, 高瀬圭, 荒井陽一, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　92　(2)　521-521　2016/10
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus Peer-reviewed

Shiho Sato, Masaki Iwasaki, Hiroyoshi Suzuki, Shunji Mugikura, Kazutaka Jin, Teiji Tominaga, Kei Takase, Shoki Takahashi, Nobukazu Nakasato

EPILEPSY RESEARCH　126　1-9　2016/10

DOI： 10.1016/j.eplepsyres.2016.06.001 　

ISSN： 0920-1211

eISSN： 1872-6844
わずかな領域の腎虚血が高血圧の原因となった分枝型腎血管性高血圧の1例高血圧の病態形成に限局性腎虚血が与える影響

三島英換, 鈴木健弘, 菊地晃一, 島久登, 清治和将, 高瀬圭, 阿部高明, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　39回　390-390　2016/09
Publisher: (NPO)日本高血圧学会
PTRA施行困難な分枝型腎血管性高血圧の治療オプションとしての選択的腎動脈塞栓術の有用性

新沢賢樹, 三島英換, 鈴木健弘, 菊地晃一, 島久登, 清治和将, 高瀬圭, 阿部高明, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　39回　390-390　2016/09
Publisher: (NPO)日本高血圧学会
腎動脈狭窄による腎虚血診断のためのDiffusion-weighted MRIの有用性と臨床応用性の検討

三島英換, 大田英揮, 鈴木健弘, 菊地晃一, 島久登, 橋本潤一郎, 高瀬圭, 阿部高明, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　39回　358-358　2016/09
Publisher: (NPO)日本高血圧学会
片側性原発性アルドステロン症における術後アウトカムの検討 lateralization indexによる層別化

森本玲, 小野美澄, 祢津昌広, 尾股慧, 手塚雄太, 五十嵐康宏, 工藤正孝, 高瀬圭, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　39回　368-368　2016/09
Publisher: (NPO)日本高血圧学会
Dual-energy CT to estimate clinical severity of chronic thromboembolic pulmonary hypertension: Comparison with invasive right heart catheterization Peer-reviewed

Hidenobu Takagi, Hideki Ota, Koichiro Sugimura, Katharina Otani, Junya Tominaga, Tatsuo Aoki, Shunsuke Tatebe, Masanobu Miura, Saori Yamamoto, Haruka Sato, Nobuhiro Yaoita, Hideaki Suzuki, Hiroaki Shimokawa, Kei Takase

EUROPEAN JOURNAL OF RADIOLOGY　85　(9)　1574-1580　2016/09

DOI： 10.1016/j.ejrad.2016.06.010 　

ISSN： 0720-048X

eISSN： 1872-7727
Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension Peer-reviewed

Haruka Sato, Hideki Ota, Koichiro Sugimura, Tatsuo Aoki, Shunsuke Tatebe, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Hideaki Suzuki, Kimio Satoh, Kei Takase, Hiroaki Shimokawa

CIRCULATION JOURNAL　80　(6)　1470-1477　2016/06

DOI： 10.1253/circj.CJ-15-1187 　

ISSN： 1346-9843

eISSN： 1347-4820
中心静脈路確保困難に対しalternative central vein routeアプローチで中心静脈カテーテルを留置した3例

榊原宏幸, 清治和将, 大山翼, 森下陽平, 高橋祐輝, 野村脩子, 加賀谷由里子, 長谷川哲也, 佐藤嘉尚, 佐藤友美, 松浦智徳, 大田英揮, 冨永循哉, 高瀬圭

IVR: Interventional Radiology　31　(Suppl.)　160-160　2016/04
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520

eISSN： 2185-6451
MP12-06 MEDIUM-TERM OUTCOMES AFTER LAPAROSCOPIC ADRENALECTOMY FOR PRIMARY ALDOSTERONISM Peer-reviewed

Yoshihide Kawasaki, Yasuhiro Kaiho, Akihiro Ito, Koji Mitsuzuka, Fumitoshi Satoh, Ryo Morimoto, Yoshikiyo Ono, Shigeto Ishidoya, Tomonori Matsuura, Hideki Ota, Kei Takase, Yoichi Arai

The Journal of Urology　195　(4)　e127　2016/04
Publisher: Elsevier {BV}
DOI： 10.1016/j.juro.2016.02.2446 　

ISSN： 0022-5347
Detection of Segmental Renal Ischemia by Diffusion-Weighted Magnetic Resonance Imaging: Clinical Utility for Diagnosis of Renovascular Hypertension Peer-reviewed

Eikan Mishima, Koichi Kikuchi, Hideki Ota, Yasutoshi Akiyama, Takehiro Suzuki, Kazumasa Seiji, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito

JOURNAL OF CLINICAL HYPERTENSION　18　(4)　364-365　2016/04

DOI： 10.1111/jch.12675 　

ISSN： 1524-6175

eISSN： 1751-7176
Association between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy: Prospective study using I-123 BMIPP SPECT/CT Peer-reviewed

Kentaro Takanami, Akira Arai, Rei Umezawa, Takashi Takeuchi, Noriynki Kadoya, Yasuyuki Taki, Keiichi Jingu, Kei Takase

RADIOTHERAPY AND ONCOLOGY　119　(1)　77-83　2016/04

DOI： 10.1016/j.radonc.2016.01.024 　

ISSN： 0167-8140
Dynamic multidetector CT and non-contrast-enhanced MR for right adrenal vein imaging: comparison with catheter venography in adrenal venous sampling Peer-reviewed

Hideki Ota, Kazumasa Seiji, Masahiro Kawabata, Nozomi Satani, Kei Omata, Yoshikiyo Ono, Yoshitsugu Iwakura, Ryo Morimoto, Tomonori Matsuura, Masataka Kudo, Junya Tominaga, Fumitoshi Satoh, Sadayoshi Ito, Kei Takase

EUROPEAN RADIOLOGY　26　(3)　622-630　2016/03

DOI： 10.1007/s00330-015-3872-3 　

ISSN： 0938-7994

eISSN： 1432-1084
Impact of Small Renal Ischemia in Hypertension Development: Renovascular Hypertension Caused by Small Branch Artery Stenosis Peer-reviewed

Eikan Mishima, Junichiro Hashimoto, Yasutoshi Akiyama, Hisato Shima, Kazumasa Seiji, Kei Takase, Takaaki Abe, Sadayoshi Ito

JOURNAL OF CLINICAL HYPERTENSION　18　(3)　248-249　2016/03

DOI： 10.1111/jch.12661 　

ISSN： 1524-6175

eISSN： 1751-7176
Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism Peer-reviewed

Yoshitsugu Iwakura, Sadayoshi Ito, Ryo Morimoto, Masataka Kudo, Yoshikiyo Ono, Masahiro Nezu, Kei Takase, Kazumasa Seiji, Shigeto Ishidoya, Yoichi Arai, Yasuharu Funamizu, Takashi Miki, Yasuhiro Nakamura, Hironobu Sasano, Fumitoshi Satoh

HYPERTENSION　67　(3)　654-660　2016/03

DOI： 10.1161/HYPERTENSIONAHA.115.05924 　

ISSN： 0194-911X

eISSN： 1524-4563
Lipomatous hypertrophy of the interatrial septumが疑われた症例

前川由依, 外山由貴, 荒井晃, 高浪健太郎, 高瀬圭, 瀧靖之

核医学　53　(1)　509-509　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
弓部置換術後遠隔期リークとの鑑別を要した人工血管周囲血腫の1例

大村健介, 大田英揮, 高瀬圭, 松浦智徳, 常陸真, 冨永循哉, 清治和将, 田村亮

Japanese Journal of Radiology　34　(Suppl.)　14-14　2016/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
FDG PET/CTを用いた脂肪を含有する副腎incidentalomaのホルモン産生能評価

高浪健太郎, 野村脩子, 高瀬圭, 金田朋洋, 荒井晃

Japanese Journal of Radiology　34　(Suppl.)　8-8　2016/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
嗄声を主訴に多発リンパ節転移が発見され、FDG-PET/CTにて指摘した前立腺癌の1例

寺尾千秋, 下村英雄, 戸恒智子, 舘脇康子, 阿部十也, 武藤達士, 瀧靖之, 荒井晃, 高浪健太郎, 高瀬圭

核医学　53　(1)　512-512　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
著明な腹水貯留を呈した原発不明癌に対してFDG-PET/CTを施行した一例

小林洋樹, 下村英雄, 舘脇康子, 阿部十也, 武藤達士, 瀧靖之, 荒井晃, 高浪健太郎, 高瀬圭

核医学　53　(1)　512-512　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
タルクによる胸膜癒着術を施行した1症例におけるFDG-PET所見

榊原宏幸, 荒井晃, 高浪健太郎, 高瀬圭, 戸恒智子, 下村英雄, 舘脇康子, 武藤達士, 瀧靖之, 渡辺みか, 井上健太郎

核医学　53　(1)　568-568　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Erratum to: Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer [Eur Radiol, DOI 10.1007/s00330-015-3847-4] Peer-reviewed

Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

European Radiology　26　(2)　340-341　2016/02/01
Publisher: Springer Verlag
DOI： 10.1007/s00330-015-3888-8 　

ISSN： 1432-1084 0938-7994

eISSN： 1432-1084
Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer Peer-reviewed

Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

EUROPEAN RADIOLOGY　26　(2)　331-339　2016/02

DOI： 10.1007/s00330-015-3847-4 　

ISSN： 0938-7994

eISSN： 1432-1084
Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer (vol 26, pg 331, 2016) Peer-reviewed

Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

EUROPEAN RADIOLOGY　26　(2)　340-341　2016/02

DOI： 10.1007/s00330-015-3888-8 　

ISSN： 0938-7994

eISSN： 1432-1084
Morphology evaluation of nonmass enhancement on breast MRI: Effect of a three-step interpretation model for readers' performances and biopsy recommendations Peer-reviewed

Akiko Shimauchi, Hideki Ota, Youichi Machida, Tamiko Yoshida, Nozomi Satani, Naoko Mori, Kei Takase, Mitsuhiro Tozaki

EUROPEAN JOURNAL OF RADIOLOGY　85　(2)　480-488　2016/02

DOI： 10.1016/j.ejrad.2015.11.043 　

ISSN： 0720-048X

eISSN： 1872-7727
Canadian CT head rule and New Orleans Criteria in mild traumatic brain injury: comparison at a tertiary referral hospital in Japan Peer-reviewed

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Kei Takase, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

SPRINGERPLUS　5　176　2016/02

DOI： 10.1186/s40064-016-1781-9 　

ISSN： 2193-1801
Standard method for ultrasound evaluation of renal arterial lesions Peer-reviewed

Yoshiki Hirooka, Hiroshi Matsuo, Michiaki Abe, Yoshio Iwashima, Keita Odashiro, Hiroshi Sato, Kei Takase, Toshiko Hirai, Makoto Matsumura, Takashi Miki

JOURNAL OF MEDICAL ULTRASONICS　43　(1)　145-162　2016/01

DOI： 10.1007/s10396-015-0651-3 　

ISSN： 1346-4523

eISSN： 1613-2254
A case of bilateral aldosterone-producing adenomas differentiated by segmental adrenal venous sampling for bilateral adrenal sparing surgery. Peer-reviewed

Morimoto R, Satani N, Iwakura Y, Ono Y, Kudo M, Nezu M, Omata K, Tezuka Y, Seiji K, Ota H, Kawasaki Y, Ishidoya S, Nakamura Y, Arai Y, Takase K, Sasano H, Ito S, Satoh F

J Hum Hypertens　30　(6)　379-385　2016

DOI： 10.1038/jhh.2015.100 　
Intra-adrenal Aldosterone Secretion: Segmental Adrenal Venous Sampling for Localization Peer-reviewed

Nozomi Satani, Hideki Ota, Kazumasa Seiji, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Masahiro Nezu, Kei Omata, Sadayoshi Ito, Fumitoshi Satoh, Kei Takase

RADIOLOGY　278　(1)　265-274　2016/01

DOI： 10.1148/radiol.2015142159 　

ISSN： 0033-8419
Pulmonary Arterial Hypertension Associated with Congenital Portosystemic Shunts Treated with Transcatheter Embolization and Pulmonary Vasodilators Peer-reviewed

Haruka Sato, Masanobu Miura, Nobuhiro Yaoita, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Kimio Satoh, Hideki Ota, Kei Takase, Koichiro Sugimura, Hiroaki Shimokawa

INTERNAL MEDICINE　55　(17)　2429-2432　2016

DOI： 10.2169/internalmedicine.55.6557 　

ISSN： 0918-2918

eISSN： 1349-7235
Utility of diffusion tensor imaging parameters for diagnosis of hemimegalencephaly Peer-reviewed

Tomomi Oikawa, Yasuko Tatewaki, Takaki Murata, Yumiko Kato, Shunji Mugikura, Kei Takase, Shoki Takahashi

Neuroradiology Journal　28　(6)　628-633　2015/12/01
Publisher: SAGE Publications Inc.
DOI： 10.1177/1971400915609334 　

ISSN： 1971-4009
Identifying the Adamkiewicz artery using 3-T time-resolved magnetic resonance angiography: its role in addition to multidetector computed tomography angiography Peer-reviewed

Hidenobu Takagi, Hideki Ota, Yutaka Natsuaki, Yoshiaki Komori, Koki Ito, Yoshikatsu Saiki, Kei Takase

JAPANESE JOURNAL OF RADIOLOGY　33　(12)　749-756　2015/12

DOI： 10.1007/s11604-015-0490-6 　

ISSN： 1867-1071

eISSN： 1867-108X
二管球CTによる肺灌流画像を用いた慢性血栓塞栓性肺高血圧症の重症度評価

高木英誠, 大田英揮, 佐藤遙, 三浦正暢, 青木竜男, 建部俊介, 杉村宏一郎, 冨永循哉, 下川宏明, 高瀬圭

日独医報　60　(2)　238-238　2015/11
Publisher: バイエル薬品(株)
ISSN： 0912-0351
A comparative study of the extent of cerebral microvascular injury following whole-brain irradiation versus reduced-field irradiation in long-term survivors of intracranial germ cell tumors Peer-reviewed

Li Li, Shunji Mugikura, Toshihiro Kumabe, Takaki Murata, Etsuro Mori, Kei Takase, Keiichi Jingu, Shoki Takahashi

RADIOTHERAPY AND ONCOLOGY　117　(2)　302-307　2015/11

DOI： 10.1016/j.radonc.2015.09.017 　

ISSN： 0167-8140
A Case of Apparent Lung Adenocarcinoma Size Reduction During Steroid Therapy Peer-reviewed

Yoshinao Sato, Katsunori Oikado, Junya Tominaga, Akira Sakurada, Ryoko Saito, Kei Takase

JOURNAL OF THORACIC IMAGING　30　(6)　W80-W81　2015/11

DOI： 10.1097/RTI.0000000000000178 　

ISSN： 0883-5993

eISSN： 1536-0237
Is there a role for segmental adrenal venous sampling and adrenal sparing surgery in patients with primary aldosteronism? Peer-reviewed

Fumitoshi Satoh, Ryo Morimoto, Kazumasa Seiji, Nozomi Satani, Hideki Ota, Yoshitsugu Iwakura, Yoshikiyo Ono, Masataka Kudo, Masahiro Nezu, Kei Omata, Yuta Tezuka, Yoshihide Kawasaki, Shigeto Ishidoya, Yoichi Arai, Kei Takase, Yasuhiro Nakamura, Keely McNamara, Hironobu Sasano, Sadayoshi Ito

EUROPEAN JOURNAL OF ENDOCRINOLOGY　173　(4)　465-477　2015/10

DOI： 10.1530/EJE-14-1161 　

ISSN： 0804-4643

eISSN： 1479-683X
骨髄移植後に閉塞性細気管支炎と肺胞蛋白症を発症し特異な画像所見と経過を呈した1例

佐藤嘉尚, 冨永循哉, 齊藤涼子, 笹原洋二, 岡田克典, 高瀬圭

日本医学放射線学会秋季臨床大会抄録集　51回　S547-S547　2015/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Posterior reversible encephalopathy syndrome treated with renin-angiotensin system blockade Peer-reviewed

Eikan Mishima, Junichiro Hashimoto, Yasutoshi Akiyama, Kazumasa Seiji, Kei Takase, Takaaki Abe, Sadayoshi Ito

JOURNAL OF THE NEUROLOGICAL SCIENCES　355　(1-2)　219-221　2015/08

DOI： 10.1016/j.jns.2015.06.007 　

ISSN： 0022-510X

eISSN： 1878-5883
【知っておきたい循環器疾患のCT・MRI(2)-胸部・腹部・末梢血管疾患Case Review-】腹部腸間膜動脈閉塞症

長谷川哲也, 木下知, 高瀬圭

画像診断　35　(9)　1100-1101　2015/07
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
【知っておきたい循環器疾患のCT・MRI(2)-胸部・腹部・末梢血管疾患Case Review-】腹部非閉塞性腸間膜虚血

長谷川哲也, 木下知, 高瀬圭

画像診断　35　(9)　1102-1103　2015/07
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
【知っておきたい循環器疾患のCT・MRI(2)-胸部・腹部・末梢血管疾患Case Review-】腹部消化管出血

木下知, 長谷川哲也, 松浦智徳, 高瀬圭

画像診断　35　(9)　1104-1105　2015/07
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
【知っておきたい循環器疾患のCT・MRI(2)-胸部・腹部・末梢血管疾患Case Review-】腹部結節性多発動脈炎

木下知, 長谷川哲也, 高瀬圭

画像診断　35　(9)　1106-1107　2015/07
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
【知っておきたい循環器疾患のCT・MRI(2)-胸部・腹部・末梢血管疾患Case Review-】腹部腎動脈狭窄症(動脈硬化性)

長谷川哲也, 木下知, 高瀬圭

画像診断　35　(9)　1108-1109　2015/07
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
【知っておきたい循環器疾患のCT・MRI(2)-胸部・腹部・末梢血管疾患Case Review-】腹部線維筋性異形成

長谷川哲也, 木下知, 高瀬圭

画像診断　35　(9)　1110-1111　2015/07
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
【知っておきたい循環器疾患のCT・MRI(2)-胸部・腹部・末梢血管疾患Case Review-】腹部 nutcracker症候群(左腎静脈捕捉症候群)

木下知, 長谷川哲也, 松浦智徳, 高瀬圭

画像診断　35　(9)　1112-1113　2015/07
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
Spontaneous rupture of a renal angiomyolipoma at 25 weeks of pregnancy treated with transarterial embolization: A case report and review of the literature Peer-reviewed

Shingo Myoen, Koji Mitsuzuka, Hideo Saito, Hideki Ota, Kei Takase, Yoichi Arai

INTERNATIONAL JOURNAL OF UROLOGY　22　(7)　710-712　2015/07

DOI： 10.1111/iju.12775 　

ISSN： 0919-8172

eISSN： 1442-2042
87歳肝血管腫自然破裂の1例 Peer-reviewed

志村充広, 水間正道, 元井冬彦, 片寄友, 高瀬圭, 海野倫明

日本臨床外科学会雑誌　76　(6)　1469-1473　2015/06

DOI： 10.3919/jjsa.76.1469 　
Measurement of Peripheral Plasma 18-Oxocortisol Can Discriminate Unilateral Adenoma From Bilateral Diseases in Patients With Primary Aldosteronism Peer-reviewed

Fumitoshi Satoh, Ryo Morimoto, Yoshikiyo Ono, Yoshitsugu Iwakura, Kei Omata, Masataka Kudo, Kei Takase, Kazumasa Seiji, Hidehiko Sasamoto, Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita, Celso E. Gomez-Sanchez, William E. Rainey, Yoichi Arai, Hironobu Sasano, Yasuhiro Nakamura, Sadayoshi Ito

HYPERTENSION　65　(5)　1096-1102　2015/05

DOI： 10.1161/HYPERTENSIONAHA.114.04453 　

ISSN： 0194-911X

eISSN： 1524-4563
CTガイド下ラジオ波焼灼によるアルドステロン産生腺腫の低侵襲治療医師主導探索的治験報告

高瀬圭, 清治和将, 森本玲, 佐藤文俊, 小野美澄, 岩倉芳倫, 尾股慧, 木下知, 伊藤貞嘉

日本内分泌学会雑誌　91　(1)　265-265　2015/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
Assessment of myocardial metabolic disorder associated with mediastinal radiotherapy for esophageal cancer -a pilot study- Peer-reviewed

Rei Umezawa, Kentaro Takanami, Noriyuki Kadoya, Yujiro Nakajima, Masahide Saito, Hideki Ota, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Takaya Yamamoto, Yojiro Ishikawa, Ken Takeda, Yasuyuki Taki, Kei Takase, Keiichi Jingu

RADIATION ONCOLOGY　10　96　2015/04

DOI： 10.1186/s13014-015-0410-z 　

ISSN： 1748-717X
Intraventricular Hemorrhage on Initial Computed Tomography as Marker of Diffuse Axonal Injury after Traumatic Brain Injury Peer-reviewed

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Li Li, Kei Takase, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

JOURNAL OF NEUROTRAUMA　32　(5)　359-365　2015/03

DOI： 10.1089/neu.2014.3453 　

ISSN： 0897-7151

eISSN： 1557-9042
Successful transcatheter closure of a congenital portsystemic shunt with interlocking detachable coils in a 3-year-old girl

佐藤信一, 木村正人, 川野研悟, 和田基, 高瀬圭, 坂本修, 呉繁夫

日本小児放射線学会雑誌　30　(2)　110-115　2015/02/20
Publisher: 日本小児放射線学会
ISSN： 0918-8487

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3歳9ヵ月女児。切迫早産のため2絨毛膜2羊膜双胎1児として帝王切開で出生した。出生後、呼吸障害と黄疸のため、酸素投与及び光線療法を施行した。日齢7のガラクトースは正常であったが、日齢48には高値を認め、持続した。生後6ヵ月に腹部CTを施行し、先天性肝外門脈体外循環短縮症と診断した。ガラクトース制限食を導入し、血中ガラクトースは正常化した。1歳7ヵ月時に施行した123I-IMP経直腸門脈血流シンチグラフィでは門脈から体循環へのシャント率は76%で、頭部MRI T1強調画像で淡蒼球に高信号を認め、マンガンの沈着を疑った。3歳を過ぎた頃から双胎同胞に比べ明らかに発語の不明瞭さが目立つようになってきたため、基底核へのマンガンの沈着による構音障害の進行を考慮し、精査およびカテーテルによる閉鎖目的で入院した。コイル塞栓術1年後において構音障害に明らかな改善は認めなかったが、淡蒼球の高信号はほぼ消失した。
Cost-Effectiveness Analysis of the Diagnosis and Treatment of Primary Aldosteronim in Japan. Peer-reviewed

Sato M, Morimoto R, Seiji K, Iwakura Y, Ono Y, Kudo M, Satoh F, Ito S, Ishibashi T, Takase K

Horm Metab Res　47　(11)　826-832　2015

DOI： 10.1055/s-0035-1559645 　
Luminal-Type Breast Cancer: Correlation of Apparent Diffusion Coefficients with the Ki-67 Labeling Index Peer-reviewed

Naoko Mori, Hideki Ota, Shunji Mugikura, Chiaki Takasawa, Takanori Ishida, Gou Watanabe, Hiroshi Tada, Mika Watanabe, Kei Takase, Shoki Takahashi

RADIOLOGY　274　(1)　66-73　2015/01

DOI： 10.1148/radiol.14140283 　

ISSN： 0033-8419
Regional Reliability of Quantitative Signal Targeting with Alternating Radiofrequency (STAR) Labeling of Arterial Regions (QUASAR) Peer-reviewed

Yasuko Tatewaki, Shuichi Higano, Yasuyuki Taki, Benjamin Thyreau, Takaki Murata, Shunji Mugikura, Daisuke Ito, Kei Takase, Shoki Takahashi

JOURNAL OF NEUROIMAGING　24　(6)　554-561　2014/11

DOI： 10.1111/jon.12076 　

ISSN： 1051-2284

eISSN： 1552-6569
従来型および新しい方式による胸管イメージング機序、技術、臨床応用(Thoracic duct imaging by conventional and new modalities: Mechanisms, techniques and clinical applications)

高浪健太郎, 高瀬圭

日本医学放射線学会秋季臨床大会抄録集　50回　S692-S692　2014/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Different Expression of 11 beta-Hydroxylase and Aldosterone Synthase Between Aldosterone-Producing Microadenomas and Macroadenomas Peer-reviewed

Yoshikiyo Ono, Yasuhiro Nakamura, Takashi Maekawa, Saulo J. A. Felizola, Ryo Morimoto, Yoshitsugu Iwakura, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoichi Arai, Celso E. Gomez-Sanchez, Sadayoshi Ito, Hironobu Sasano, Fumitoshi Satoh

HYPERTENSION　64　(2)　438-+　2014/08

DOI： 10.1161/HYPERTENSIONAHA.113.02944 　

ISSN： 0194-911X

eISSN： 1524-4563
Predictors of Decreasing Glomerular Filtration Rate and Prevalence of Chronic Kidney Disease After Treatment of Primary Aldosteronism: Renal Outcome of 213 Cases Peer-reviewed

Yoshitsugu Iwakura, Ryo Morimoto, Masataka Kudo, Yoshikiyo Ono, Kei Takase, Kazumasa Seiji, Yoichi Arai, Yasuhiro Nakamura, Hironobu Sasano, Sadayoshi Ito, Fumitoshi Satoh

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　99　(5)　1593-1598　2014/05

DOI： 10.1210/jc.2013-2180 　

ISSN： 0021-972X

eISSN： 1945-7197
Early CT Findings to Predict Early Death in Patients with Traumatic Brain Injury: Marshall and Rotterdam CT Scoring Systems Compared in the Major Academic Tertiary Care Hospital in Northeastern Japan Peer-reviewed

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Kiyoshi Ishii, Li Li, Kei Takase, Shigeki Kushimoto, Shoki Takahashi

ACADEMIC RADIOLOGY　21　(5)　605-611　2014/05

DOI： 10.1016/j.acra.2014.01.017 　

ISSN： 1076-6332

eISSN： 1878-4046
PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues Peer-reviewed

Saulo J. A. Felizola, Yasuhiro Nakamura, Yoshikiyo Ono, Kanako Kitamura, Kumi Kikuchi, Yoshiaki Onodera, Kazue Ise, Kei Takase, Akira Sugawara, Namita Hattangady, William E. Rainey, Fumitoshi Satoh, Hironobu Sasano

JOURNAL OF MOLECULAR ENDOCRINOLOGY　52　(2)　159-167　2014/04

DOI： 10.1530/JME-13-0248 　

ISSN： 0952-5041
Characterization of lipid-rich adrenal tumors by FDG PET/CT: Are they hormone-secreting or not? Peer-reviewed

Kentaro Takanami, Tomohiro Kaneta, Ryo Morimoto, Fumitoshi Satoh, Yasuhiro Nakamura, Kei Takase, Shoki Takahashi

ANNALS OF NUCLEAR MEDICINE　28　(2)　145-153　2014/02

DOI： 10.1007/s12149-013-0793-6 　

ISSN： 0914-7187

eISSN： 1864-6433
Isoform-Specific Monoclonal Antibodies Against 3 beta-Hydroxysteroid Dehydrogenase/Isomerase Family Provide Markers for Subclassification of Human Primary Aldosteronism Peer-reviewed

Masao Doi, Fumitoshi Satoh, Takashi Maekawa, Yasuhiro Nakamura, Jean-Michel Fustin, Motomi Tainaka, Yunhong Hotta, Yukari Takahashi, Ryo Morimoto, Kei Takase, Sadayoshi Ito, Hironobu Sasano, Hitoshi Okamura

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　99　(2)　E257-E262　2014/02

DOI： 10.1210/jc.2013-3279 　

ISSN： 0021-972X

eISSN： 1945-7197
保存療法中B型大動脈解離に対するスタチン効果臨床研究(中間解析報告)

松尾諭志, 熊谷, 紀一郎, 本吉, 直孝, 菅原, 由美, 福田, 幾夫, 大徳, 和之, 板谷, 博幸, 三浦, 誠, 渡辺, 卓, 吉田, 聖二郎, 多田, 憲生, 高木, 英誠, 大田, 英揮, 高瀬, 圭, 齋木佳克

日本心臓血管外科学会雑誌　43　(Suppl.)　383-383　2014/01
Publisher:
ISSN： 0285-1474

eISSN： 1883-4108
MRI findings of-radiation-induced myocardial damage in patients with oesophageal cancer Peer-reviewed

Umezawa R, Ota H, Takanami K, Ichinose A, Matsushita H, Saito H, Takase K, Jingu K

Clinical Radiology　69　(12)　1273-1279　2014

DOI： 10.1016/j.crad.2014.08.010 　
Assessment of Myocardial Metabolic Disorder Associated With Mediastinal Radiation Therapy for Esophageal Cancer Peer-reviewed

Umezawa R, Takanami K, Ota H, Kaneta T, Kadoya N, Fujita Y, Arai A, Arai K, Matsushita H, Takase K, Jingu K

International Journal of Radiation Oncology Biology Physics　90　S205　2014

DOI： 10.1016/j.ijrobp.2014.05.762 　
Evaluation of Spinal cord ischemia with a retrievable stent graft is useful for determining the type of repair for a case of patch aneurysm Peer-reviewed

Junetsu Akasaka, Kei Takase, Koichi Tabayashi

Annals of Vascular Surgery　28　(5)　1313-e3　2014
Publisher: Elsevier Inc.
DOI： 10.1016/j.avsg.2013.08.024 　

ISSN： 1615-5947 0890-5096
Magnetic Resonance Imaging Findings of Radiation-Induced Myocardial Damage in Patients With Esophageal Cancer Peer-reviewed

R. Umezawa, K. Jingu, K. Takase, H. Ota, K. Takanami, T. Kaneta, K. Takeda, H. Matsushita, S. Takahashi

Int J Radiat Oncol Biol Phys　87　(2)　S291-S292　2013/10
Detection of invasive components in cases of breast ductal carcinoma in situ on biopsy by using apparent diffusion coefficient MR parameters Peer-reviewed

Naoko Mori, Hideki Ota, Shunji Mugikura, Chiaki Takasawa, Junya Tominaga, Takanori Ishida, Mika Watanabe, Kei Takase, Shoki Takahashi

European Radiology　23　(10)　2705-2712　2013/10

DOI： 10.1007/s00330-013-2902-2 　

ISSN： 0938-7994 1432-1084

eISSN： 1432-1084
Evaluation of radiation-induced myocardial damage using iodine-123 beta-methyl-iodophenyl pentadecanoic acid scintigraphy Peer-reviewed

Rei Umezawa, Kei Takase, Keiichi Jingu, Kentaro Takanami, Hideki Ota, Tomohiro Kaneta, Ken Takeda, Haruo Matsushita, Hisanori Ariga, Shoki Takahashi, Shogo Yamada

JOURNAL OF RADIATION RESEARCH　54　(5)　880-889　2013/09

DOI： 10.1093/jrr/rrt011 　

ISSN： 0449-3060
Cardiac output obtained from test bolus injections as a factor in contrast injection rate revision of following coronary CT angiography Peer-reviewed

Masahiko Konno, Yoshiyuki Hosokai, Akihito Usui, Mitsuya Abe, Toshiki Tateishi, Yusuke Kawasumi, Masashi Tsuda, Hideki Ota, Kei Takase, Haruo Saito

ACTA RADIOLOGICA　53　(10)　1107-1111　2012/12

DOI： 10.1258/ar.2012.120276 　

ISSN： 0284-1851
Size Validation of an Adrenal Vein Model for Development of an In Vitro Model with Realistic Geometrical Structure

Yusuke Hoshino, Kei Takase, Kazumasa Seiji, Makoto Ohta

Proceedings Ninth International Conference on Flow Dynamics　620-622　2012/09
Properties of N-Butyl Cyanoacrylate-iodized Oil Mixtures for Arterial Embolization: In Vitro and In Vivo Experiments Peer-reviewed

Chiaki Takasawa, Kazumasa Seiji, Kenichi Matsunaga, Toshio Matsuhashi, Makoto Ohta, Shuya Shida, Kei Takase, Shoki Takahashi

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　23　(9)　1215-1221　2012/09

DOI： 10.1016/j.jvir.2012.06.022 　

ISSN： 1051-0443
Hemodynamics in the pulmonary artery of a patient with pneumothorax Peer-reviewed

J. J. Christophe, T. Ishikawa, Y. Imai, K. Takase, M. Thiriet, T. Yamaguchi

Medical Engineering and Physics　34　(6)　725-732　2012/07

DOI： 10.1016/j.medengphy.2011.09.016 　

ISSN： 1350-4533 1873-4030
Patient-specific modelling of pulmonary airflow using GPU cluster for the application in medical practice Peer-reviewed

T. Miki, X. Wang, T. Aoki, Y. Imai, T. Ishikawa, K. Takase, T. Yamaguchi

Computer Methods in Biomechanics and Biomedical Engineering　15　(7)　771-778　2012/07

DOI： 10.1080/10255842.2011.560842 　

ISSN： 1025-5842 1476-8259
Endovascular aneurysmal models at the external iliac artery of dogs Peer-reviewed

Kenichi Matsunaga, Chiaki Takasawa, Kazumasa Seiji, Kei Takase, Shoki Takahashi, Toshio Matsuhashi, Yasuhiro Nakamura, Fumiyoshi Fujisihima

JOURNAL OF VASCULAR SURGERY　55　(6)　1742-1748　2012/06

DOI： 10.1016/j.jvs.2011.11.056 　

ISSN： 0741-5214
Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation Peer-reviewed

Kentaro Takanami, Takayuki Yamada, Masashi Tsuda, Kei Takase, Kazuyuki Ishida, Yasuhiro Nakamura, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno, Shoki Takahashi

ABDOMINAL IMAGING　36　(4)　447-456　2011/08

DOI： 10.1007/s00261-010-9649-x 　

ISSN： 0942-8925
Additional value of FDG PET/CT to contrast-enhanced CT in the differentiation between benign and malignant intraductal papillary mucinous neoplasms of the pancreas with mural nodules Peer-reviewed

Kentaro Takanami, Tomomichi Hiraide, Masashi Tsuda, Yasuhiro Nakamura, Tomohiro Kaneta, Kei Takase, Hiroshi Fukuda, Shoki Takahashi

ANNALS OF NUCLEAR MEDICINE　25　(7)　501-510　2011/08

DOI： 10.1007/s12149-011-0494-y 　

ISSN： 0914-7187

eISSN： 1864-6433
18-Oxocortisol Measurement in Adrenal Vein Sampling as a Biomarker for Subclassifying Primary Aldosteronism Peer-reviewed

Yasuhiro Nakamura, Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Kei Takase, Celso E. Gomez-Sanchez, Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita, William E. Rainey, Hironobu Sasano, Sadayoshi Ito

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　96　(8)　E1272-E1278　2011/08

DOI： 10.1210/jc.2010-2785 　

ISSN： 0021-972X
High-resolution magnetic resonance imaging of rotator cuff tears using a microscopy coil: noninvasive detection without intraarticular contrast material Peer-reviewed

Shin Hitachi, Kei Takase, Minoru Tanaka, Yuichi Tojo, Shiro Tabata, Kazuhiro Majima, Shuichi Higano, Shoki Takahashi

JAPANESE JOURNAL OF RADIOLOGY　29　(7)　466-474　2011/08

DOI： 10.1007/s11604-011-0583-9 　

ISSN： 1867-1071
骨盤内発症Castleman病を合併した右副腎褐色細胞腫の一例 Peer-reviewed

岩倉芳倫, 森本玲, 小野美澄, 工藤正孝, 村上治, 石澤賢一, 張替秀郎, 清治和将, 高瀬圭, 高橋昭喜, 石戸谷滋人, 荒井陽一, 渡辺みか, 笹野公伸, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　87　(1)　318-318　2011/04
Primary aldosteronism A Japanese perspective Peer-reviewed

Fumitoshi Satoh, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Masataka Kudo, Kei Takase, Sadayoshi Ito

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS　12　(1)　11-14　2011/03

DOI： 10.1007/s11154-011-9161-9 　

ISSN： 1389-9155
The Fatal Risk in Hepatic Artery Embolization for Hemostasis after Pancreatic and Hepatic Surgery: Importance of Collateral Arterial Pathways Peer-reviewed

Akihiro Sato, Takayuki Yamada, Kei Takase, Toshio Matsuhashi, Shuichi Higano, Tomohiro Kaneda, Shinichi Egawa, Kazunori Takeda, Tadashi Ishibashi, Shoki Takahashi

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　22　(3)　287-293　2011/03

DOI： 10.1016/j.jvir.2010.11.023 　

ISSN： 1051-0443
Thoracic Duct Visualization: Combined Use of Multidetector-Row Computed Tomography and Magnetic Resonance Imaging Peer-reviewed

Takumi Kato, Kei Takase, Hirofumi Ichikawa, Susumu Satomi, Shoki Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　35　(2)　260-265　2011/03

DOI： 10.1097/RCT.0b013e31820a0b0e 　

ISSN： 0363-8715
MDCT of the artery of Adamkiewicz Peer-reviewed

Kei Takase, Shoki Takahashi

Neurovascular Imaging: MRI and Microangiography　451-463　2011
Publisher: Springer London
DOI： 10.1007/978-1-84882-134-7_17 　
Difficult-to-control hypertension due to bilateral aldosterone-producing adrenocortical microadenomas associated with a cortisol-producing adrenal macroadenoma.

Morimoto R, Kudo M, Murakami O, Takase K, Ishidoya S, Nakamura Y, Ishibashi T, Takahashi S, Arai Y, Suzuki T, Sasano H, Ito S, Satoh F

J Hum Hypertens　25　(2)　114-121　2011

DOI： 10.1038/jhh.2010.35 　
Simultaneous Evaluation of the Whole Aorta and Artery of Adamkiewicz by MDCT. Peer-reviewed

Takase K

Annals of vascular diseases　4　(4)　286-292　2011

DOI： 10.3400/avd.di.11.00725 　

ISSN： 1881-641X
Demonstration of the Anatomy of the Esophageal Artery Using Multidetector-Row Helical Computed Tomography Peer-reviewed

Takumi Kato, Kei Takase, Hirofumi Ichikawa, Susumu Satomi, Shoki Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　34　(6)　939-944　2010/11

DOI： 10.1097/RCT.0b013e3181ed9cf4 　

ISSN： 0363-8715
Bronchial Artery Anatomy: Preoperative 3D Simulation with Multidetector CT Peer-reviewed

Yoshiaki Morita, Kei Takase, Hirofumi Ichikawa, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Shoki Takahashi

RADIOLOGY　255　(3)　934-943　2010/06

DOI： 10.1148/radiol.10081220 　

ISSN： 0033-8419
左側腹部痛を契機に診断された無症候性褐色細胞腫の一例

岩倉芳倫, 森本玲, 工藤正孝, 村上治, 高瀬圭, 高橋昭喜, 石戸谷滋人, 荒井陽一, 笹野公伸, 木村伯子, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　86　(1)　153-153　2010/03
多発性内分泌腫瘍2b型に発生した副腎髄質過形成を伴う両側褐色細胞腫の一例

森本玲, 工藤正孝, 村上治, 高瀬圭, 高橋昭喜, 石戸谷滋人, 荒井陽一, 笹野公伸, 葛西伸彦, 佐藤文俊, 木村伯子, 伊藤貞嘉

日本内分泌学会雑誌　86　(1)　137-137　2010/03
Patient-specific morphological and blood flow analysis of pulmonary artery in the case of severe deformations of the lung due to pneumothorax Peer-reviewed

Jean-Joseph Christophe, Takuji Ishikawa, Noriaki Matsuki, Yohsuke Imai, Kei Takase, Marc Thiriet, Takami Yamaguchi

Journal of Biomechanical Science and Engineering　5　(5)　485-498　2010

DOI： 10.1299/jbse.5.485 　

ISSN： 1880-9863
肺動脈血栓弁の診断にMDCT(multi-detector CT)が有用であった1例 Peer-reviewed

柿崎周平, 田澤, 星一, 大野, 忠行, 土屋, 滋, 新田, 能郎, 齋木, 佳克, 高瀬圭

日本小児科学会雑誌　113　(12)　1880-1880　2009/12
Treatment of in-stent restenosis with beraprost sodium: An experimental study of short- and intermediate-term effects in dogs Peer-reviewed

Kazumasa Seiji, Masashi Tsuda, Toshio Matsuhashi, Kei Takase, Hideo Miyachi, Takayuki Yamada, Tadashi Ishibashi, Shuichi Higano, Shoki Takahashi

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY　36　(12)　1164-1169　2009/12

DOI： 10.1111/j.1440-1681.2009.05209.x 　

ISSN： 0305-1870
Differentiation of Femoral and Inguinal Hernias on the Basis of Anteroposterior Relationship to the Inguinal Ligament on Multidimensional Computed Tomography Peer-reviewed

Masahiro Kitami, Kei Takase, Masahiro Tsuboi, Yuya Rikimaru, Takashi Hakamatsuka, Takayuki Yamada, Shoki Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　33　(5)　678-681　2009/09

DOI： 10.1097/RCT.0b013e3181977a0a 　

ISSN： 0363-8715
アルドステロン自律過剰分泌を合併するクッシング症候群の診断と治療

森本玲, 佐藤文俊, 工藤正孝, 村上治, 松田謙, 高瀬圭, 石橋忠司, 高橋昭喜, 石戸谷滋人, 荒井陽一, 鈴木貴, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　85　(1)　269-269　2009/04
アルドステロン産生腫瘍の診断の進歩 MDCT副腎静脈造影マップ法副腎静脈サンプリングの成功率と診断精度アルドステロン産生腺腫の局在診断の精度と判定基準の検討

佐藤文俊, 森本玲, 工藤正孝, 松田謙, 宇留野晃, 高瀬圭, 石橋忠司, 荒井陽一, 鈴木貴, 笹野公伸, 村上治, 伊藤貞嘉

日本内分泌学会雑誌　85　(1)　190-190　2009/04
Tagged cine magnetic resonance imaging with a finite element model can predict the severity of retrosternal adhesions prior to redo cardiac surgery Peer-reviewed

Ichiro Yoshioka, Yoshikatsu Saiki, Azusa Ichinose, Kei Takase, Shoki Takahashi, Toshiro Ohashi, Masaaki Sato, Koichi Tabayashi

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY　137　(4)　957-962　2009/04

DOI： 10.1016/j.jtcvs.2008.10.036 　

ISSN： 0022-5223
MORPHOLOGY AND BLOOD FLOW ANALYSIS OF PULMONARY ARTERIES UNDER RESPIRATORY DISORDERS Peer-reviewed

Jean-Joseph Christophe, Takuji Ishikawa, Yohsuke Imai, Noriaki Matsuki, Kei Takase, Takami Yamaguchi

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B　1037-1038　2009
術後下垂体機能が回復したACTH産生下垂体macroadenomaによるCushing病の一例

岩倉芳倫, 森本玲, 工藤正孝, 村上治, 高瀬圭, 日向野修一, 高橋昭喜, 池田秀敏, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　85Suppl.　10-13　2009
Correct Diagnosis of Vascular Encasement and Longitudinal Extension of Hilar Cholangiocarcinoma by Four-Channel Multidetector-Row Computed Tomography Peer-reviewed

Tadayuki Okumoto, Akihiro Sato, Takayuki Yamada, Kei Takase, Toshio Matsuhashi, Masashi Tsuda, Kazumasa Seiji, Tadashi Ishibashi, Shuichi Higano, Yu Katayose, Michiaki Unno, Shoki Takahashi

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　217　(1)　1-8　2009/01

DOI： 10.1620/tjem.217.1 　

ISSN： 0040-8727

eISSN： 1349-3329
対側副腎にアルドステロン産生腺腫を伴ったCushing症候群の一例 Peer-reviewed

山田友里恵, 森本玲, 佐藤文俊, 工藤正孝, 村上治, 高瀬圭, 石橋忠司, 高橋昭喜, 石戸谷滋人, 荒井陽一, 鈴木貴, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　84　(3)　864-864　2008/12
[Use of the keyhole technique for 3.0T MRI dynamic imaging]. Peer-reviewed

Itou D, Nagasaka T, Yanagawa I, Yoshida S, Takase K

Nihon Hoshasen Gijutsu Gakkai zasshi　64　(12)　1562-1567　2008/12
Publisher: Japanese Society of Radiological Technology (JSRT)
DOI： 10.6009/jjrt.64.1562 　

ISSN： 0369-4305

More details Close

We studied the feasibility of high spatial and temporally resolved imaging by a combination of keyhole imaging, which is a fast imaging method, and a 3.0T MRI system which inherently has a high signal-to-noise ratio (SNR). In keyhole imaging, full k-space reference data are collected, followed by repeated dynamic acquisition of the central low-frequency data alone, and this makes dynamic acquisition faster. The purpose of our article is to describe the effects of the reference data on the reconstructed dynamic images with the assumption of vessel visualization. For efficient use of keyhole imaging, it is important to optimize the keyhole percentage and timing of reference data acquisition for the object of interest.
Differentiation of Pathologic Subtypes of Papillary Renal Cell Carcinoma on CT Peer-reviewed

Takayuki Yamada, Mareyuki Endo, Masahiro Tsuboi, Toshio Matsuhashi, Kei Takase, Shuichi Higano, Shoki Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　191　(5)　1559-1563　2008/11

DOI： 10.2214/AJR.07.3181 　

ISSN： 0361-803X
High-resolution monochrome liquid crystal display versus efficient household colour liquid crystal display: comparison of their diagnostic performance with unenhanced CT images in focal liver lesions Peer-reviewed

Yusuke Kawasumi, Takayuki Yamada, Hideki Ota, Masahiro Tsuboi, Kei Takase, Akihiro Sato, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

EUROPEAN RADIOLOGY　18　(10)　2148-2154　2008/10

DOI： 10.1007/s00330-008-1008-8 　

ISSN： 0938-7994
特発性器質化肺炎(COP)と細気管支肺胞上皮癌(BAC)が合併し、画像上鑑別が困難であった1例 Peer-reviewed

森菜緒子, 山田隆之, 清治和将, 高瀬圭, 松橋俊夫, 津田雅視, 奥本忠之, 川住祐介, 高橋昭喜, 渡辺みか

日本医学放射線学会秋季臨床大会抄録集　44回　S553-S553　2008/09
MRI of cardiac sarcoidosis: Basal and subepicardial localization of myocardial lesions and their effect on left ventricular function Peer-reviewed

Azusa Ichinose, Hiroki Otani, Minako Oikawa, Kei Takase, Haruo Saito, Hiroaki Shimokawa, Shoki Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　191　(3)　862-869　2008/09

DOI： 10.2214/AJR.07.3089 　

ISSN： 0361-803X
Radiologic anatomy of the right adrenal vein: Preliminary experience with MDCT Peer-reviewed

Tomonori Matsuura, Kei Takase, Hideki Ota, Takayuki Yamada, Akihiro Sato, Fumitoshi Satoh, Shoki Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　191　(2)　402-408　2008/08

DOI： 10.2214/AJR.07.3338 　

ISSN： 0361-803X
Validation of the use of calibration factors between the iodine concentration and the computed tomography number measured outside the objects for estimation of iodine concentration inside the objects: phantom experiment Peer-reviewed

Kentaro Takanami, Shuichi Higano, Kei Takase, Tomohiro Kaneta, Takayuki Yamada, Hiroki Ishiya, Issei Mori, Shoki Takahashi

RADIATION MEDICINE　26　(4)　237-243　2008/05

DOI： 10.1007/s11604-007-0220-9 　

ISSN： 1862-5274
Electrocardiographic characteristics of the variants of idiopathic left ventricular outflow tract ventricular tachyarrhythmias Peer-reviewed

Koji Kumagai, Koji Fukuda, Yuji Wakayama, Yoshinao Sugai, Masanori Hirose, Nobuhiro Yamaguchi, Kei Takase, Yasuteru Yamauchi, Atsushi Takahashi, Kazutaka Aonuma, Hiroaki Shimokawa

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY　19　(5)　495-501　2008/05

DOI： 10.1111/j.1540-8167.2007.01085.x 　

ISSN： 1045-3873
Validation of the use of calibration factors between the iodine concentration and the computed tomography number measured outside the objects for estimation of iodine concentration inside the objects: Phantom experiment Peer-reviewed

Kentaro Takanami, Shuichi Higano, Kei Takase, Tomohiro Kaneta, Takayuki Yamada, Hiroki Ishiya, Issei Mori, Shoki Takahashi

Radiation Medicine - Medical Imaging and Radiation Oncology　26　(4)　237-243　2008/05

DOI： 10.1007/s11604-007-0220-9 　

ISSN： 0288-2043 1862-5274

eISSN： 1862-5274
Perforated and nonperforated appendicitis: Defect in enhancing appendiceal wall - Depiction with multi-detector row CT Peer-reviewed

Masahiro Tsuboi, Kei Takase, Iwao Kaneda, Tadashi Ishibashi, Takayuki Yamada, Masahiro Kitami, Shuichi Higano, Shoki Takahashi

RADIOLOGY　246　(1)　142-147　2008/01

DOI： 10.1148/radiol.2461051760 　

ISSN： 0033-8419
Virtual CT thoracoscopy: preoperative simulation for thoracoscopic surgery of esophageal cancer Peer-reviewed

Yoshiaki Morita, Kei Takase, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Shoki Takahashi, Hirofumi Ichikawa

ABDOMINAL IMAGING　32　(6)　679-687　2007/11

DOI： 10.1007/s00261-006-9165-1 　

ISSN： 0942-8925
Localization of aldosterone-producing adrenocortical adenomas: Significance of adrenal venous sampling Peer-reviewed

Fumitoshi Satoh, Takaaki Abe, Masayuki Tanemoto, Masahiro Nakamura, Michiaki Abe, Akira Uruno, Ryo Morimoto, Akihiro Sato, Kei Takase, Shigeto Ishidoya, Yoichi Arai, Takashi Suzuki, Hironobu Sasano, Tadashi Ishibashi, Sadayoshi Ito

HYPERTENSION RESEARCH　30　(11)　1083-1095　2007/11

DOI： 10.1291/hypres.30.1083 　

ISSN： 0916-9636
Dilation of renal artery stenosis after administration of losartan Peer-reviewed

Masayuki Tanemoto, Kei Takase, Takayuki Yamada, Akihiro Satoh, Takaaki Abe, Sadayoshi Ito

HYPERTENSION RESEARCH　30　(10)　999-1002　2007/10

DOI： 10.1291/hypres.30.999 　

ISSN： 0916-9636
術前MDCTにて副腎結節性病変を認めなかった原発性アルドステロン症の自験例に関する検討

森本玲, 佐藤文俊, 村上治, 宇留野晃, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉, 高瀬圭, 山田隆之, 石橋忠司, 高橋昭喜, 石戸谷滋人, 佐藤信, 荒井陽一, 鈴木貴, 笹野公伸

日本内分泌学会雑誌　83　(2)　460-460　2007/09
Primary aldosteronism: a pictorial essay Peer-reviewed

Tadashi Ishibashi, Fumitoshi Satoh, Takayuki Yamada, Akihiro Sato, Toshio Matsuhashi, Kei Takase

ABDOMINAL IMAGING　32　(4)　504-514　2007/08

DOI： 10.1007/s00261-006-9151-7 　

ISSN： 0942-8925
[Cardiac CT and MRI]. Peer-reviewed

Ichinose A, Takase K, Takahashi S, Kagaya Y, Shimokawa H

Nihon rinsho. Japanese journal of clinical medicine　65 Suppl 4　406-411　2007/04

ISSN： 0047-1852
Tagged cine MRIを用いた再手術症例胸骨後面の癒着評価の有用性

吉岡一朗, 齋木, 佳克, 井口, 篤志, 一瀬あずさ, 高瀬, 圭, 田林晄一

日本心臓血管外科学会雑誌　36　(Suppl.)　277-277　2007/01
Publisher:
ISSN： 0285-1474

eISSN： 1883-4108
Peripheral Pulmonary Artery Aneurysms in Patients with Pulmonary Artery Hypertension Peer-reviewed

Masahito Sakuma, Jun Demachi, Jun Suzuki, Jun Nawata, Tohru Takahashi, Koichiro Sugimura, Minako Oikawa, Kei Takase, Kenji Hoshino, Shinko Souma, Kunio Shirato

INTERNAL MEDICINE　46　(13)　979-984　2007

DOI： 10.2169/internalmedicine.46.6462 　

ISSN： 0918-2918
Preoperative multidetector computed tomography evaluation of the artery of Adamkiewicz and its origin Peer-reviewed

Kei Takase, Junetsu Akasaka, Yoshihiro Sawamura, Hideki Ota, Akihiro Sato, Takayuki Yamada, Shuichi Higano, Kazumasa Igarashi, Yoshihiro Chiba, Shoki Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　30　(5)　716-722　2006/09

DOI： 10.1097/01.rct.0000228150.35410.45 　

ISSN： 0363-8715

eISSN： 1532-3145
Comparison of MDCT and MRI for evaluating the intraductal component of breast cancer Peer-reviewed

Akiko Shimauchi, Takayuki Yamada, Akihiro Sato, Kei Takase, Shin Usami, Takanori Ishida, Takuya Moriya, Shoki Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　187　(2)　322-329　2006/08

DOI： 10.2214/AJR.05.0876 　

ISSN： 0361-803X
Diagnosis of aortic diseases using multidetector computed tomography Peer-reviewed

Kei Takase, Hideki Ota, Hiroya Rikimaru, Akihiro Sato, Takayuki Yamada, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

Radiation Medicine - Medical Imaging and Radiation Oncology　24　(5)　405-414　2006/06

DOI： 10.1007/s11604-006-0046-x 　

ISSN： 0288-2043
Assessing the extent of breast cancer using multidetector row helical computed tomography Peer-reviewed

K Takase, A Furuta, N Harada, T Takahashi, K Igarashi, Y Chiba, K Haga, S Takahashi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　30　(3)　479-485　2006/05

DOI： 10.1097/00004728-200605000-00021 　

ISSN： 0363-8715
Atlantoaxial osteoarthritis in rheumatoid arthritis: FDG PET/CT findings Peer-reviewed

T Kaneta, T Kakamatsuka, T Yamada, K Takase, A Sato, S Higano, H Ito, H Fukuda, S Takahashi, S Yamada

CLINICAL NUCLEAR MEDICINE　31　(4)　209-209　2006/04

DOI： 10.1097/01.rlu.0000204124.79497.bb 　

ISSN： 0363-9762
Evaluation of the relationship between physiological FDG uptake in the heart and age, blood glucose level, fasting period, and hospitalization Peer-reviewed

T Kaneta, T Hakamatsuka, K Takanami, T Yamada, K Takase, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

ANNALS OF NUCLEAR MEDICINE　20　(3)　203-208　2006/04

DOI： 10.1007/bf03027431 　

ISSN： 0914-7187
FDG PET in solitary metastastic/secondary tumor of the kidney: A report of three cases and a review of the relevant literature

T Kaneta, T Hakamatsuka, T Yamada, K Takasa, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

ANNALS OF NUCLEAR MEDICINE　20　(1)　79-82　2006/01

DOI： 10.1007/BF02985596 　

ISSN： 0914-7187
Types and frequencies of biliary tract variations associated with a major portal venous anomaly: Analysis with multi-detector row CT cholangiography Peer-reviewed

M Kitami, K Takase, G Murakami, S Ko, M Tsuboi, H Saito, S Higano, Y Nakajima, S Takahashi

RADIOLOGY　238　(1)　156-166　2006/01

DOI： 10.1148/radiol.2381041783 　

ISSN： 0033-8419
FDG PET in solitary metastastic/secondary tumor of the kidney: A report of three cases and a review of the relevant literature Peer-reviewed

T Kaneta, T Hakamatsuka, T Yamada, K Takasa, A Sato, S Higano, S Kinomura, H Fukuda, S Takahashi, S Yamada

ANNALS OF NUCLEAR MEDICINE　20　(1)　79-82　2006/01

DOI： 10.1007/bf02985596 　

ISSN： 0914-7187
Time-related changes in computed tomographic appearance and pathologic findings after radiofrequency ablation of the rabbit lung: Preliminary experimental study Peer-reviewed

J Tominaga, H Miyachi, K Takase, T Matsuhashi, T Yamada, A Sato, H Saito, T Ishibashi, M Endoh, S Higano, S Takahashi

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　16　(12)　1719-1726　2005/12

DOI： 10.1097/01.RVI.0000182507.37324.3E 　

ISSN： 1051-0443
【癌取扱い規約からみた悪性腫瘍の病期診断と画像診断】泌尿器科癌腎・尿管 Invited

石橋忠司, 佐藤明弘, 山田隆之, 松橋俊夫, 高瀬圭

臨床放射線　50　(11)　1546-1554　2005/10
Quantitative vascular measurements in arterial occlusive disease Peer-reviewed

Hideki Ota, Kei Takase, Hiroya Rikimaru, Masahiro Tsuboi, Takayuki Yamada, Akihiro Sato, Shuichi Higano, Tadashi Ishibashi, Shoki Takahashi

Radiographics　25　(5)　1141-1158　2005/09

DOI： 10.1148/rg.255055014 　

ISSN： 1527-1323
原発性アルドステロン症の局在診断における副腎静脈サンプリングと最新型16列MDCTの有用性 Invited Peer-reviewed

佐藤文俊, 種本雅之, 中村匡宏, 阿部倫明, 宇留野晃, 森本玲, 佐藤明弘, 高瀬圭, 石戸谷滋人, 荒井陽一, 鈴木貴, 笹野公伸, 石橋忠司, 阿部高明, 伊藤貞嘉

日本高血圧学会総会28回プログラム・抄録集　59-59　2005/09
Quantitative vascular measurements in arterial occlusive disease Peer-reviewed

H Ota, K Takase, H Rikimaru, M Tsuboi, T Yamada, A Sato, S Higano, T Ishibashi, S Takahashi

RADIOGRAPHICS　25　(5)　1141-1158　2005/09

DOI： 10.1143/rg.255055014 　

ISSN： 0271-5333
原発性アルドステロン症の局在診断における副腎静脈サンプリングの意義 Peer-reviewed

佐藤文俊, 種本雅之, 中村匡宏, 鈴木恵綾, 茶木辰治, 森本玲, 宇留野晃, 佐藤明弘, 高瀬圭, 石戸谷滋人, 荒井洋一, 鈴木貴, 笹野公伸, 石橋忠司, 阿部高明, 伊藤貞嘉

日本内分泌学会雑誌　81　(1)　177-177　2005/04
Heterogeneity of subvesical ducts or the ducts of Luschka: A study using drip-infusion cholangiography-computed tomography in patients and cadaver specimens Peer-reviewed

M Kitami, G Murakami, D Suzuki, K Takase, M Tsuboi, H Saito, S Takahashi

WORLD JOURNAL OF SURGERY　29　(2)　217-223　2005/02

DOI： 10.1007/s00268-004-7652-5 　

ISSN： 0364-2313
MDCT for vascular diseases; one stop shopping imaging

Kei Takase, Y. Chiba

Japanese Journal of Clinical Radiology　50　(1)　67-77　2005

ISSN： 0009-9252
Spiegel's lobe bile ducts often drain into the right hepatic duct or its branches: Study using drip-infusion cholangiography-computed tomography in 179 consecutive patients Peer-reviewed

M Kitami, G Murakami, S Ko, K Takase, M Tuboi, H Saito, Y Nakajima, S Takahashi

WORLD JOURNAL OF SURGERY　28　(10)　1001-1006　2004/10

DOI： 10.1007/s00268-004-7483-4 　

ISSN： 0364-2313
Pseudoaneurysm of the inferior epigastric artery successfully treated by ultrasound-guided compression Peer-reviewed

K Takase, T Kazama, K Abe, Y Chiba, H Saito, S Takahashi

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY　27　(5)　520-522　2004/09

DOI： 10.1007/s00270-003-2767-x 　

ISSN： 0174-1551
MDCT compared with digital subtraction angiography for assessment of lower extremity arterial occlusive disease: Importance of reviewing cross-sectional images Peer-reviewed

H Ota, K Takase, K Igarashi, Y Chiba, K Haga, H Saito, S Takahashi

AMERICAN JOURNAL OF ROENTGENOLOGY　182　(1)　201-209　2004/01

DOI： 10.2214/ajr.182.1.1820201 　

ISSN： 0361-803X
Another blood supply to Adamkiewicz's artery Peer-reviewed

Junetsu Akasaka, Masahiro Sakurai, Kei Takase, Kiichiro Kumagai, Koichi Tabayashi

Japanese Journal of Thoracic and Cardiovascular Surgery　52　(9)　432-434　2004
Publisher: Japanese Association for Thoracic Surgery
DOI： 10.1007/s11748-004-0039-6 　

ISSN： 1344-4964
膜様構造物を伴った動脈管開存症(PDA)の一例:心電同期3D-CTの有用性

大田英揮, 高瀬圭, 高山真, 祐川博康

血栓と循環　11　(4)　385-385　2003/12
Publisher:
ISSN： 0919-7036
Surgical Repair for Tracheo-Innominate Artery Fistula with a Muscle Flap Peer-reviewed

Yoshihiro Sawamura, Kei Takase, Norio Higuchi, Sekinori Kikuchi, Takashi Ito, Koichi Tabayashi

Japanese Journal of Thoracic and Cardiovascular Surgery　51　(11)　630-633　2003
Publisher: Japanese Association for Thoracic Surgery
DOI： 10.1007/BF02736707 　

ISSN： 1344-4964
急性虫垂炎の診断と治療方針決定におけるCTの有用性

工藤博典, 金田巌, 樋口則男, 古田昭彦, 石橋悟, 初貝和明, 庄子成美, 高瀬圭, 高橋徹

東北医学雑誌　114　(1)　146-146　2002/08
Publisher: 東北医学会
ISSN： 0040-8700
マルチスライスヘリカルCTを用いた乳癌の広がり診断

庄子成美, 金田巌, 樋口則男, 古田昭彦, 石橋悟, 初貝和明, 中川有, 工藤博典, 高瀬圭, 高橋徹

東北医学雑誌　114　(1)　155-155　2002/08
Publisher: 東北医学会
ISSN： 0040-8700
虫垂炎診断及び手術適応決定におけるマルチスライスヘリカルCTの有用性

工藤博典, 金田巖, 樋口則男, 古田昭彦, 石橋悟, 初貝和明, 庄子成美, 高瀬圭, 高橋徹

日本消化器外科学会雑誌　35　(7)　1142-1142　2002/07
Publisher: (一社)日本消化器外科学会
ISSN： 0386-9768

eISSN： 1348-9372
Three-dimensional Imaging of coronary artery bypass grafts Peer-reviewed

Y Sawamura, K Takase, H Saito, S Kikuchi, T Ito

ANNALS OF THORACIC SURGERY　73　(5)　1655-1655　2002/05

DOI： 10.1016/s0003-4975(01)02741-2 　

ISSN： 0003-4975
Demonstration of the artery of Adamkiewicz at multi-detector row helical CT Peer-reviewed

K Takase, Y Sawamura, K Igarashi, Y Chiba, K Haba, H Saito, S Takahashi

RADIOLOGY　223　(1)　39-45　2002/04

DOI： 10.1148/radiol.2231010513 　

ISSN： 0033-8419
Pericardiectomy for post-coronary artery bypass grafting constrictive pericarditis; strategy for safe and complete pericardiectomy

T. Shibuya, M. Ohmi, S. Kawamoto, M. Shimizu, M. Ohuchi, Y. Sawamura, S. Kikuchi, T. Ito, K. Takase

Kyobu geka. The Japanese journal of thoracic surgery　55　1149-1152　2002/01/01

ISSN： 0021-5252
Three-dimensional imaging of coronary artery bypass grafts

Yoshihiro Sawamura, Kei Takase, Haruo Saito, Sekinori Kikuchi, Takashi Ito

Annals of Thoracic Surgery　73　(5)　1655　2002

DOI： 10.1016/S0003-4975(01)02741-2 　

ISSN： 0003-4975
Noninvasive postoperative angiography for internal mammary artery grafts

Y Sawamura, K Takase, H Saito, S Kikuchi, T Ito

CIRCULATION　104　(3)　373-374　2001/07

DOI： 10.1161/01.CIR.104.3.373 　

ISSN： 0009-7322
Obturator herniation visualized by multislice helical CT

K Takase, A Furuta, H Akama

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS　192　(3)　411-411　2001/03

DOI： 10.1016/S1072-7515(00)00804-8 　

ISSN： 1072-7515
Multislice helical computed tomography for minimally invasive cardiac surgery

Yoshihiro Sawamura, Kei Takase, Sekinori Kikuchi, Takashi Ito

Annals of Thoracic Surgery　71　(5)　1707　2001

DOI： 10.1016/S0003-4975(00)02013-0 　

ISSN： 0003-4975
Bronchial artery aneurysm treated with percutaneous transluminal coil embolization

Kei Sakuma, Kei Takase, Haruo Saito, Masayuki Zuguchi, Koichi Tabayashi

The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi　49　(5)　330-332　2001

DOI： 10.1007/BF02913144 　

ISSN： 1344-4964
A pitfall of reusing disposable apparatus for endoscopic surgery [2] (multiple letters)

Y. Sawamura, K. Takase, H. Saito, S. Kikuchi, T. Ito, A. S. Wechsler

Journal of Thoracic and Cardiovascular Surgery　120　617　2000/09/18

ISSN： 0022-5223
Relationship between the pixel value in digital subtraction angiography and iodine concentration: Study in high iodine concentration with original phantom

Koichi Chida, Sai Masahiro, Haruo Saito, Kei Takase, Masayuki Zuguchi, Masatoshi Sasaki, Tokutaro Sato

Tohoku Journal of Experimental Medicine　190　(3)　169-176　2000
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.190.169 　

ISSN： 0040-8727
Popliteal artery entrapment syndrome: Aberrant origin of gastrocnemius muscle shown by 3D CT

K Takase, S Imakita, S Kuribayashi, Y Onishi, M Takamiya

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　21　(4)　523-528　1997/07

DOI： 10.1097/00004728-199707000-00003 　

ISSN： 0363-8715

eISSN： 1532-3145
Psychiatric wandering behaviour in dementia patients correlated with increased striatal dopamine D2 receptor as shown by [11C]YM-09151-2 and positron emission tomography

K. Meguro, M. Itoh, K. Yanai, K. Takase, S. Yamaguchi, T. Ido, A. Yamadori

European Journal of Neurology　4　(3)　221-226　1997
Publisher: Blackwell Publishing Ltd
DOI： 10.1111/j.1468-1331.1997.tb00338.x 　

ISSN： 1351-5101
MR FINDINGS OF AVULSIVE CORTICAL IRREGULARITY OF THE DISTAL FEMUR

T YAMAZAKI, S MARUOKA, S TAKAHASHI, H SAITO, K TAKASE, M NAKAMURA, K SAKAMOTO

SKELETAL RADIOLOGY　24　(1)　43-46　1995/01

DOI： 10.1007/BF02425946 　

ISSN： 0364-2348
Renal cell carcinoma associated with chronic renal failure: Evaluation with sonographic angiography

Kei Takase, Shoki Takahashi, Satoru Tazawa, Yoshio Terasawa, Kiyohiko Sakamoto

Radiology　192　(3)　787-792　1994
Publisher: Radiological Society of North America Inc.
DOI： 10.1148/radiology.192.3.8058948 　

ISSN： 0033-8419

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Misc. 397

静脈血酸素分圧は副腎静脈サンプリング中の副腎静脈同定に有用である

手塚雄太, 尾股慧, 小野美澄, 丹内啓允, 鎌田裕基, 小黒草太, 高瀬圭, 佐藤文俊, 片桐秀樹

日本内分泌学会雑誌　101　(1)　2025

ISSN： 0029-0661
右副腎皮質髄質混合腫瘍と左副腎腫瘍によるサブクリニカルクッシング症候群を合併した一例

小林雅幸, 小野美澄, 宍戸愛, 矢浦一磨, 沼畑貴生, 佐藤俊宏, 黒澤聡子, 久保晴丸, 手塚雄太, 尾股慧, 山崎有人, 高瀬圭, 伊藤明宏, 鈴木貴, 片桐秀樹

日本内分泌学会雑誌　100　(1)　341-341　2024/05
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
初診時に高レニン高アルドステロン血症を呈した片側性原発性アルドステロン症の一例

手塚雄太, 矢浦一磨, 久保晴丸, 尾股慧, 小野美澄, 菅原明, 高瀬圭, 伊藤明宏, 山崎有人, 鈴木貴, 片桐秀樹

日本内分泌学会雑誌　99　(5)　1501-1501　2024/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
ロボット支援下副腎手術の衆知を集める(標準化を目指して) 原発性アルドステロン症に対するロボット支援下副腎部分切除術

川崎芳英, 手塚雄太, 小野美澄, 尾股慧, 佐藤友紀, 方山博路, 佐竹洋平, 佐藤琢磨, 川守田直樹, 山下慎一, 小黒草太, 高瀬圭, 片桐秀樹, 伊藤明宏

日本内分泌外科学会雑誌　41　(Suppl.1)　S152-S152　2024/04
Publisher: (一社)日本内分泌外科学会
ISSN： 2434-6535

eISSN： 2758-8785
術後合併症に対するIVR・内視鏡的ドレナージ治療消化器外科術後合併症に対するVIABAHNステントグラフトの治療成績

三浦孝之, 日下彬子, 井上亨悦, 青木修一, 伊関雅裕, 堂地大輔, 中山瞬, 石田晶玄, 大塚英郎, 水間正道, 中川圭, 森川孝則, 高瀬圭, 亀井尚, 海野倫明

日本腹部救急医学会雑誌　43　(2)　357-357　2023/02
Publisher: (一社)日本腹部救急医学会
ISSN： 1340-2242

eISSN： 1882-4781
CT画像を用いたvViTと畳込みニューラルネットワークの腎癌組織型鑑別性能の比較

臼崎琢磨, 高木英誠, 高木英誠, 佐藤友美, 小黒草太, 高瀬圭

泌尿器画像診断・治療技術研究会プログラム・抄録集　10th　2023
Medical students’ education and radiology

Naoko Mori, Kei Takase

Japanese Journal of Radiology　40　(11)　1210-1211　2022/11

DOI： 10.1007/s11604-022-01310-0 　

ISSN： 1867-1071

eISSN： 1867-108X
Letter to the editor on “Second‑opinion reads in prostate MRI: added value of subspecialty interpretation and review at multidisciplinary rounds”

Naoko Mori, Shunji Mugikura, Kei Takase

Abdominal Radiology　47　(11)　3958-3960　2022/11

DOI： 10.1007/s00261-022-03653-8 　

ISSN： 2366-004X

eISSN： 2366-0058
2回目のAVSを要した原発性アルドステロン症の一例

高橋成輝, 尾股慧, 玉懸直人, 手塚雄太, 小野美澄, 森本玲, 小黒草太, 高瀬圭, 田中哲洋, 佐藤文俊

日本内分泌学会雑誌　98　(2)　556-556　2022/10
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
Letter to the editor on “The MRI estimations of placental thickness and cervical length correlate with postpartum hemorrhage (PPH) in patients with risk for placenta accreta spectrum (PAS) disorders”

Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

Placenta　128　72　2022/10

DOI： 10.1016/j.placenta.2022.08.008 　

ISSN： 0143-4004

eISSN： 1532-3102
Diffusion kurtosis imaging: An effective method to evaluate the grade of glioma based on the assessment of histological nuclear size and entropy

Naoko Mori, Shunji Mugikura, Kei Takase

Clinical Neurology and Neurosurgery　221　2022/10

DOI： 10.1016/j.clineuro.2022.107415 　

ISSN： 0303-8467

eISSN： 1872-6968
【アルドステロンをめぐる臨床課題】原発性アルドステロン症治療におけるラジオ波治療の意義

柳垣聡, 小黒草太, 清治和将, 高瀬圭, 尾股慧, 手塚雄太, 小野美澄, 森本玲, 田中哲洋, 佐藤文俊

糖尿病・内分泌代謝科　55　(2)　204-209　2022/08
Publisher: (有)科学評論社
ISSN： 2435-1946
当院における亜全胃温存膵頭十二指腸切除術後腹腔内出血の治療成績

井上亨悦, 石田晶玄, 大塚英郎, 水間正道, 中川圭, 森川孝則, 大沼忍, 亀井尚, 高瀬圭, 海野倫明

日本消化器外科学会総会　77回　RS19-3　2022/07
Publisher: (一社)日本消化器外科学会
心電図同期心筋血流SPECTによる心機能解析:その原理と臨床的有用性

木曽啓祐, 高浪健太郎, 齊藤美穂子, 外山由貴, 前川由依, 益田淳朗, 高瀬圭

日本医学放射線学会秋季臨床大会抄録集　58th　2022

ISSN： 0048-0428
Risk Prediction Modeling for Thymic Tumor: Validation of MR Sequence Combination using Imputation and Machine Learning Techniques

SHIMIZU Hiroaki, MORI Naoko, REN Hainan, MUGIKURA Shunji, TAKASE Kei

日本医学放射線学会総会抄録集　81st　2022

ISSN： 0048-0428
American College of Rheumatology and the European League Against Rheumatism classification criteria for IgG4-related disease: an update for radiologists

Hainan Ren, Naoko Mori, Satoko Sato, Shunji Mugikura, Atsushi Masamune, Kei Takase

Japanese Journal of Radiology　40　(9)　876-893　2022

DOI： 10.1007/s11604-022-01282-1 　

ISSN： 1867-1071

eISSN： 1867-108X
Less contrast-enhanced areas within lymph nodes in the delayed phase of contrast-enhanced MRI: a suspicious finding for lymph node metastases

Naoko Mori, Shunji Mugikura, Kei Takase

Clinical and Experimental Metastasis　39　(5)　713-714　2022

DOI： 10.1007/s10585-022-10161-y 　

ISSN： 0262-0898

eISSN： 1573-7276
外科におけるAI利用の現状と展開 AIによる食道癌術前リンパ節診断

高橋梢, 大村和元, 高浪健太郎, 谷山裕亮, 佐藤千晃, 高屋快, 岡本宏史, 福富俊明, 八嶋嘉之, 石田孝宣, 海野倫明, 高瀬圭, 亀井尚

日本外科学会定期学術集会抄録集　121回　NES-6　2021/04
Publisher: (一社)日本外科学会
心臓核医学による心機能解析現在の成果と将来展望(Cardiac Functional Analysis by Nuclear Cardiology: Current Achievements and Future Prospects)

木曽啓祐, 樋口慧, 大田英揮, 安田聡, 高瀬圭

日本循環器学会学術集会抄録集　85回　ME02-3　2021/03
Publisher: (一社)日本循環器学会
観測者モデルによる心臓サルコイドーシスPET画像診断能の評価

直井純一郎, 高浪健太郎, 志田原美保, 酒井大輔, 小田桐逸人, 高瀬圭, 高瀬圭

核医学(Web)　58　(Supplement)　2021

ISSN： 2189-9932
Texture Analysis of High-Resolution 3D T2-Weighted Images for Diagnosis of Lymph Node Metastasis of Breast Cancer

SHIMIZU Hiroaki, MORI Naoko, MUGIKURA Shunji, OGUMA Yo, SATO Satoko, TAKASE Kei

日本医学放射線学会総会抄録集　80th　2021

ISSN： 0048-0428
Effective Quantitative Parameters of Vessel Wall Imaging in Distinguishing Unstable from Stable Intracranial Aneurysms

MORI Naoko, MUGIKURA Shunji, ENDO Hidenori, SHIMIZU Hiroaki, HIGUCHI Kenichi, TAKAHASHI Shoki, TAKASE Kei

日本医学放射線学会総会抄録集　80th　2021

ISSN： 0048-0428
Effective Texture Features for Predicting Placenta Accreta Spectrum using T2-weighted Images

REN Hainan, MORI Naoko, KAGEYAMA Sakiko, OGUMA Yo, SHIMIZU Hiroaki, MUGIKURA Shunji, TAKASE Kei

日本医学放射線学会総会抄録集　80th　2021

ISSN： 0048-0428
AIによる食道癌術前リンパ節診断

高橋梢, 大村和元, 高浪健太郎, 谷山裕亮, 佐藤千晃, 高屋快, 岡本宏史, 福富俊明, 高瀬圭, 亀井尚

日本食道学会学術集会プログラム・抄録集　74回　99-99　2020/12
Publisher: (NPO)日本食道学会
当院でのリンパ漏・乳糜漏に対する超音波ガイド下リンパ管造影の検討

影山咲子, 大田英揮, 益田淳朗, 佐藤友美, 森田佳明, 高瀬圭

超音波医学　47　(Suppl.)　S461-S461　2020/11
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
非虚血心血管疾患の核医学イメージング循環器領域のデバイス・グラフト感染診断における核医学の有用性と限界

木曽啓祐, 立石恵実, 井元晃, 寺川裕介, 太田靖利, 西井達矢, 堀之内宏樹, 樋口慧, 村川圭三, 福田哲也, 高瀬圭

核医学　57　(Suppl.)　S101-S101　2020/10
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Ultrasound-guided intranodal lymphangiography for lymphorrhea or chylorrhea

影山咲子, 大田英揮, 益田淳朗, 佐藤友美, 森田佳明, 高瀬圭

超音波医学 Supplement　47　2020

ISSN： 1881-9311
Quantitative analysis of high-resolution 3D-T2 weighted images for the diagnosis of lymph node metastasis of breast cancer

SHIMIZU Hiroaki, MORI Naoko, TAKASAWA Chiaki, MUGIKURA Shunji, TAKASE Kei

日本医学放射線学会総会抄録集　79th　2020

ISSN： 0048-0428
重症大動脈弁狭窄症に対する経カテーテル弁置換術はBNPと左室肥大の軽減に相関して冠血流予備能を改善する

土屋聡, 松本泰治, 大田英揮, 菊池翼, 杉澤潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 鈴木祐輔, 高橋潤, 熊谷紀一郎, 斎木佳克, 高瀬圭, 下川宏明

日本心血管画像動態学会プログラム・抄録集　30th　2020
乳がん患者における化学療法前後のマルチモダリティを用いた心機能評価

杉村宏一郎, 照井洋輔, 大田英揮, 多田寛, 佐藤遥, 後岡広太郎, 石田孝宣, 高瀬圭, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　13th　2020
3T MRIを用いた原発性アルドステロン症のサブタイプにおける心形態,機能,組織性状の検討

樋口慧, 大田英揮, 清治和将, 手塚雄太, 森本玲, 西井達矢, 福田哲也, 高瀬圭

日本心血管画像動態学会プログラム・抄録集　30th　2020
A case of ultrasound-guided percutaneous transhepatic treatment for occluded choledocho-jejunostomy after living liver transplantation

影山咲子, 大田英揮, 鎌田裕基, 高瀬圭, 宮城重人

超音波医学 Supplement　47　2020

ISSN： 1881-9311
Exercise Training Ameliorates Vasodilator Capacity of Coronary Microvessels in Patients With Vasospastic Angina -A New Therapeutic Approach for the Coronary Functional Disorder

Jun Sugisawa, Yasuharu Matsumoto, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Masashi Takeuchi, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Kajitani, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

CIRCULATION　140　2019/11

ISSN： 0009-7322

eISSN： 1524-4539
CardioOncologyの現状と未来当院データと本邦における多施設共同研究への発展

杉村宏一郎, 大田英揮, 多田寛, 照井洋輔, 佐藤遥, 後岡広太郎, 石田孝宣, 高瀬圭, 下川宏明

日本心臓病学会学術集会抄録　67回　SS-B10　2019/09
Publisher: (一社)日本心臓病学会
肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

佐々木健吾, 宮城重人, 笹嶋秀憲, 宮崎勇希, 藤尾淳, 西村隆一, 中西渉, 戸子台和哲, 大田英揮, 高瀬圭, 亀井尚, 海野倫明

移植　54　(総会臨時)　200-200　2019/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947
Fetal or Prenatal Magnetic Resonance Imaging Invited

Tomomi Sato, Masahiro Kitami, Hideki Ota, Kei Takase

Japanese Journal of Imaging Diagnosis　39　(7)　756-767　2019/06
腎動脈狭窄や腎内レニン産生の局在を認めない高レニン性高血圧の一例

菅原典子, 内田奈生, 木越隆晶, 佐々木太郎, 木村正人, 鈴木健弘, 阿部高明, 高瀬圭, 呉繁夫

日本小児腎臓病学会雑誌　32　(1Suppl.)　178-178　2019/05
Publisher: (一社)日本小児腎臓病学会
ISSN： 0915-2245
血管エコー標準的評価法の作成で何が変わったか? 当院における腎動脈エコーガイドラインの活用検査法および教育体制を中心に

船水康陽, 三木俊, 三木未佳, 伊藤記彦, 阿部倫明, 高瀬圭

超音波検査技術　44　(Suppl.)　S94-S94　2019/04
Publisher: (一社)日本超音波検査学会
ISSN： 1881-4506
Segmental AVSから考えるアルドステロン分泌動態の多様性;PA Sendai Studyレジストリーの解析より

森本玲, 手塚雄太, 手塚雄太, 尾股慧, 小野美澄, 清治和将, 川崎芳英, 山崎有人, 伊藤明宏, 高瀬圭, 笹野公伸, 佐藤文俊

日本内分泌学会雑誌　95　(1)　194　2019/04/01

ISSN： 0029-0661
癌患者における潜在性化学療法関連心機能障害早期検出に対する心臓MRIの有用性(Usefulness of Cardiac Magnetic Resonance Imaging for Early Detection of Subclinical Chemotherapy-related Cardiac Dysfunction in Cancer Patients)

照井洋輔, 杉村宏一郎, 大田英揮, 多田寛, 佐藤遥, 後岡広太郎, 建部俊介, 宮田敏, 坂田泰彦, 石田孝宜, 高瀬圭, 下川宏明

日本循環器学会学術集会抄録集　83回　OJ33-3　2019/03
Publisher: (一社)日本循環器学会
乳癌患者における化学療法による心毒性を早期発見するための2D speckle tracking心エコーの有用性(Usefulness of 2D Speckle Tracking Echocardiography for Early Detection of Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

後岡広太郎, 杉村宏一郎, 藤原淳子, 照井洋輔, 佐藤遥, 多田寛, 太田英揮, 船水康陽, 三木俊, 高瀬圭, 石田孝宣, 下川宏明

日本循環器学会学術集会抄録集　83回　PJ022-1　2019/03
Publisher: (一社)日本循環器学会
コイル塞栓術後の再開通評価に対する造影MRIの有用性

鎌田裕基, 佐藤友美, 大田英揮, 清治和将, 高瀬圭

Japanese Journal of Radiology　37　(Supplement)　2019

ISSN： 1867-1071
慢性血栓塞栓性肺高血圧症に対する4D flow MRI:肺動脈拡張術前後に於る血流動態解析

大田英揮, 孫文羽, 佐藤遥, 杉村宏一郎, 高瀬圭

日本心血管画像動態学会プログラム・抄録集　29th　2019
超高齢者に発症した左胃大網動脈瘤破裂の1例

千葉和治, 水間正道, 林洋毅, 畠達夫, 伊関雅裕, 高舘達之, 川口桂, 大塚英郎, 森川孝則, 中川圭, 元井冬彦, 亀井尚, 内藤剛, 高瀬圭, 海野倫明

日本臨床外科学会雑誌　80　2019

ISSN： 1345-2843
I-123 BMIPP経口投与による胸管シンチグラフィの基礎的検討

高浪健太郎, 小田桐逸人, 志田原美保, 高瀬圭

核医学　55　(Suppl.)　S172-S172　2018/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
MRIの設置および利用状況調査

佐藤美帆, 別所俊一郎, 稲葉洋平, 町田好男, 高瀬圭

日本放射線技術学会雑誌　74　(9)　976-976　2018/09
Publisher: (公社)日本放射線技術学会
ISSN： 0369-4305

eISSN： 1881-4883
Experimental analysis of AAA treatment by multi-layer stent and fate of abdominal aortic branches Peer-reviewed

Simon Tupin, Kei Takase, Makoto Ohta

8th World Congress of Biomechanics　2018/07
神経線維腫症1型に高血圧を合併した2症例

山口祐樹, 木村正人, 川野研悟, 大田千晴, 呉繁夫, 大浦敏博, 小林朋子, 高瀬圭

日本小児科学会雑誌　122　(6)　1106-1106　2018/06
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
慢性腎臓病合併原発性アルドステロン症症例における患側副腎摘除の意義

手塚雄太, 祢津昌広, 森本玲, 工藤正孝, 五十嵐康宏, 清治和将, 高瀬圭, 荒井陽一, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　94　(1)　336-336　2018/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
当科における転移性副腎腫瘍に対する診療実績

工藤正孝, 手塚雄太, 森本玲, 祢津昌広, 五十嵐康宏, 清治和将, 高瀬圭, 山崎有人, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　94　(1)　429-429　2018/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
産道出血の血管塞栓術後に側副血行路の塞栓を要した1例

佐藤友美, 松浦智徳, 清治和将, 高瀬圭, 西郡秀和, 星合哲郎, 岩間憲之, 濱田裕貴, 齋藤昌利

Japanese Journal of Radiology　36　(Supplement)　1　2018/02/25

ISSN： 1867-1071
副鼻腔に進展したくも膜嚢胞の1例

大山翼, 村田隆起, 麦倉俊司, 北見昌広, 明石敏昭, 佐藤志帆, 外山由貴, Mata-Mbemba Daddy, 李麗, 田村元, 高橋昭喜, 高瀬圭

Japanese Journal of Radiology　36　(Suppl.)　3-3　2018/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
癌性髄膜炎との鑑別が困難であった静脈洞血栓症の1例

村田隆紀, 梅津篤司, 麦倉俊司, 北見昌広, 明石敏昭, 佐藤志帆, 樋口慧, 李麗, 田村元, 高橋昭喜, 高瀬圭

Japanese Journal of Radiology　36　(Suppl.)　13-13　2018/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
Native T1値と細胞外容積分画を用いた放射線心筋傷害の評価

高木英誠, 大田英揮, 高瀬圭, 梅沢玲, 神宮啓一

Japanese Journal of Radiology　36　(Suppl.)　2-2　2018/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
I-123BMIPP経口投与による胸管シンチグラフィの基礎的検討

高浪健太郎, 小田桐逸人, 志田原美保, 高瀬圭

核医学(Web)　55　(Supplement)　2018

ISSN： 2189-9932
当院における塩化ラジウム(²²³Ra)の初期経験

太田瑛梨, 鎌田裕基, 外山由貴, 齋藤美穂子, 高浪健太郎, 高瀬圭, 高橋紀善, 石川陽二郎, 山本貴也, 梅澤玲, 松下晴雄, 神宮啓一

核医学(Web)　55　(1)　2018

ISSN： 2189-9932
Imaging findings of the chemoradiation-therapy related cardiac complications for thoracic malignancies

高浪健太郎, 梅澤玲, 神宮啓一, 高瀬圭

臨床放射線　63　(1)　53-60　2018/01
Publisher: 金原出版
DOI： 10.18888/rp.0000000308 　

ISSN： 0009-9252
初発時と再発時にカテコラミン産生能の差異を認めた悪性傍神経節腫の一例

手塚雄太, 山崎有人, 森本玲, 祢津昌広, 工藤正孝, 五十嵐康宏, 高瀬圭, 宮城重人, 伊藤貞嘉, 笹野公伸, 佐藤文俊

日本内分泌学会雑誌　93　(4)　1463-1463　2017/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
泌尿器の画像診断と放射線治療画像診断機能性副腎疾患(原発性アルドステロン症など) Invited

大村健介, 高橋祐輝, 大田英揮, 壷井匡浩, 高瀬圭

臨床放射線　62　(11)　1401‐1407　2017/10

DOI： 10.18888/rp.0000000153 　

ISSN： 0009-9252
心臓MRI検査を用いた食道癌化学放射線療法後の心筋障害に対する前向き研究

梅澤玲, 角谷倫之, 大田英揮, 中島祐二朗, 齋藤正英, 高橋紀善, 高瀬圭, 神宮啓一

日本癌治療学会学術集会抄録集　55回　P127-3　2017/10
Publisher: (一社)日本癌治療学会
心嚢内に発生したmalignant peripheral nerve sheath tumor(MPNST)の1例

樋口慧, 大田英揮, 川本俊輔, 齋木佳克, 山内康太, 石岡千加史, 渡辺みか, 谷内真司, 高瀬圭

日独医報　62　(1)　80-80　2017/09
Publisher: バイエル薬品(株)
ISSN： 0912-0351
Further Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan

Shunji Mugikura, Miki Fujimura, Shoki Takahashi, Kei Takase

RADIOLOGY　284　(1)　301-302　2017/07

DOI： 10.1148/radiol.2017170252 　

ISSN： 0033-8419
心臓MRI検査を用いた食道癌化学放射線療法後の心筋障害に対する前向き研究

梅澤玲, 角谷倫之, 大田英揮, 高橋紀善, 高瀬圭, 神宮啓一

日本食道学会学術集会プログラム・抄録集　71回　P27-7　2017/06
Publisher: (NPO)日本食道学会
動脈・静脈疾患の臨床研究動向動脈硬化の新規イメージング MRIプラークイメージング Invited

森下陽平, 大田英揮, 高瀬圭

日本臨床　75　231‐234　2017/05

ISSN： 0047-1852
先天性肝外門脈体循環シャントに対してInterventional Radiology(IVR)による治療を行った2例

橋本昌俊, 田中拡, 北見昌広, 高瀬圭, 和田基, 佐々木英之, 風間理郎, 工藤博典, 中村恵美, 櫻井毅, 遠藤悠紀, 仁尾正記

日本小児外科学会雑誌　53　(3)　709-709　2017/05
Publisher: (NPO)日本小児外科学会
ISSN： 0288-609X
腎動脈狭窄による腎虚血評価のための拡散強調MRIの有用性と臨床応用性

三島英換, 大田英揮, 鈴木健弘, 秋山由雅子, 高瀬圭, 阿部高明, 伊藤貞嘉

日本腎臓学会誌　59　(3)　232　2017/04/25

ISSN： 0385-2385
アルドステロン産生腺腫における18-oxocortisol合成の意義

手塚雄太, 中村保宏, 北田容章, 祢津昌広, 小野美澄, 岩倉芳倫, 森本玲, 工藤正孝, 清治和将, 高瀬圭, 荒井陽一, 伊勢和恵, 山崎有人, 伊藤貞嘉, 出澤真理, 笹野公伸, 佐藤文俊

日本内分泌学会雑誌　93　(1)　297-297　2017/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
二管球CTによる肺灌流画像を用いた慢性血栓塞栓性肺高血圧症の重症度評価

高木英誠, 大田英揮, 高瀬圭

Japanese Journal of Radiology　35　(Supplement)　1-1　2017/02/25
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
基底核萎縮と尿崩症で発症したoccult germinomaの1例

野村脩子, 明石敏昭, 麦倉俊司, 佐藤志帆, 舘脇康子, 村田隆紀, 加藤裕美子, Mbemba Mata, 李麗, 高瀬圭

Japanese Journal of Radiology　35　(Suppl.)　7-7　2017/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
後縦隔原発悪性リンパ腫の1例

片桐佑, 冨永循哉, 榊原宏幸, 森下陽平, 高橋祐輝, 野村脩子, 加賀谷由里子, 長谷川哲也, 木下知, 佐藤嘉尚, 嶋内亜希子, 森菜緒子, 松浦智徳, 大田英揮, 常陸真, 北見昌広, 清治和将, 高瀬圭, 中村保宏, 岡田克典

Japanese Journal of Radiology　35　(Suppl.)　1-1　2017/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
経皮的肺動脈拡張術の慢性血栓塞栓性肺高血圧症患者での両心機能・肺動脈内血流への効果心臓MRIでの検討

佐藤遥, 大田英揮, 杉村宏一郎, 建部俊介, 青木竜男, 山本沙織, 矢尾板信裕, 神津克也, 紺野亮, 佐藤公雄, 高瀬圭, 下川宏明

日本心血管画像動態学会プログラム・抄録集　27th　66　2017
Segmental AVSにて片側複数病変が示唆された原発性アルドステロン症の一例

手塚雄太, 山崎有人, 中村保宏, 岩倉芳倫, 森本玲, 工藤正孝, 高瀬圭, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　92　(3)　798-798　2017/01
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
原発性アルドステロン症を伴ったエストロゲン産生副腎皮質腺腫の一例

手塚雄太, 山崎有人, 森本玲, 北脇優子, 中村保宏, 小野美澄, 岩倉芳倫, 工藤正孝, 尾股慧, 祢津昌広, 五十嵐康宏, 清治和将, 高瀬圭, 荒井陽一, 伊藤貞嘉, 笹野公伸, 佐藤文俊

日本内分泌学会雑誌　92　(3)　1007-1008　2017/01
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
Prediction of symptomatic cardiac toxicity in the patients who underwent chemoradiotherapy for esophageal cancer by myocardial fatty acid metabolic imaging using I-123 BMIPP SPECT/CT

K. Takanami, A. Arai, R. Umezawa, K. Jingu, K. Takase

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　43　S545-S546　2016/10

ISSN： 1619-7070

eISSN： 1619-7089
【副腎腫瘍診療Update】原発性アルドステロン症の診断と治療

川崎芳英, 石戸谷滋人, 森本玲, 松浦智徳, 清治将司, 海法康裕, 伊藤明宏, 高瀬圭, 荒井陽一

泌尿器外科　29　(10)　1507-1511　2016/10
Publisher: 医学図書出版(株)
ISSN： 0914-6180
アルドステロン産生腺腫における18‐oxocortisol産生についての免疫組織化学的検討

手塚雄太, 手塚雄太, 中村保宏, 伊勢和恵, 山崎有人, 祢津昌広, 小野美澄, 岩倉芳倫, 森本玲, 工藤正孝, 五十嵐康宏, 高瀬圭, 荒井陽一, 伊藤貞嘉, 笹野公伸, 佐藤文俊, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　39th　331　2016/09/30
腹腔内出血を伴う外傷性膵・十二指腸損傷に対してIVRを先行し一期的に膵頭十二指腸切除を施行した1例

遠山慎吾, 前田晋平, 有明恭平, 益田邦洋, 工藤克昌, 深瀬耕二, 林洋毅, 元井冬彦, 内藤剛, 高瀬圭, 海野倫明

Japanese Journal of Acute Care Surgery　6　(2)　219-219　2016/09
Publisher: 日本Acute Care Surgery学会
Focal Decrease in Cardiac 123I-Meta-Iodobenzylguanidine Uptake in Patients with Anderson-Fabry Disease

Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Syunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　22　(9)　S178-S178　2016/09

ISSN： 1071-9164

eISSN： 1532-8414
脳卒中発症後に原発性アルドステロン症の診断に至った症例の臨床的特徴の解明

工藤正孝, 森本玲, 岩倉芳倫, 小野美澄, 祢津昌広, 手塚雄太, 五十嵐康宏, 清治和将, 麦倉俊司, 高瀬圭, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　39回　355-355　2016/09
Publisher: (NPO)日本高血圧学会
アルドステロンと原発性アルドステロン症の新知見病態生理、チャンネル変異、診断そして治療原発性アルドステロン症の診断と治療 update

森本玲, 小野美澄, 祢津昌広, 尾股慧, 手塚雄太, 五十嵐康宏, 工藤正孝, 岩倉芳倫, 中村保宏, 清治和将, 高瀬圭, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　39回　245-245　2016/09
Publisher: (NPO)日本高血圧学会
褐色細胞腫・傍神経節腫患者における心臓超音波所見の手術前後の変化

尾股慧, 森本玲, 高瀬圭, 大内憲明, 渡辺みか, 中村保宏, 笹野公伸, 佐藤文俊, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　39回　420-420　2016/09
Publisher: (NPO)日本高血圧学会
原発性アルドステロン症患者における夜間頻尿の検討

川崎芳英, 伊藤明宏, 海法康裕, 森本玲, 高瀬圭, 石戸谷滋人, 荒井陽一

泌尿器外科　29　(臨増)　906-906　2016/05
Publisher: 医学図書出版(株)
ISSN： 0914-6180
治療抵抗性高血圧の治療戦略治療抵抗性高血圧症の治療戦略原発性アルドステロン症

佐藤文俊, 森本玲, 小野美澄, 岩倉芳倫, 祢津昌広, 尾股慧, 手塚雄太, 五十嵐康宏, 工藤正孝, 清治和将, 高瀬圭, 山崎有人, 笹野公伸, 伊藤貞嘉

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　5回　128-128　2016/05
Publisher: (NPO)日本高血圧学会
腹腔鏡下副腎摘除術が施行された原発性アルドステロン症患者の中期的な予後の検討

川崎芳英, 石戸谷滋人, 海法康裕, 森本玲, 小野美澄, 松浦智徳, 清治和将, 山下慎一, 伊藤明宏, 高瀬圭, 荒井陽一

日本泌尿器科学会総会　104回　PP2-171　2016/04
Publisher: (一社)日本泌尿器科学会総会事務局
副腎腫瘍診療に求められるパートナーシップ機能性副腎腫瘍の外科治療に際して内科医に期待される役割原発性アルドステロン症とクッシング症候群

森本玲, 川崎芳英, 石戸谷滋人, 清治和将, 中村保宏, 笹野公伸, 高瀬圭, 荒井陽一, 佐藤文俊, 伊藤貞嘉

日本泌尿器科学会総会　104回　PPS14-1　2016/04
Publisher: (一社)日本泌尿器科学会総会事務局
ニューモシスチス肺炎を発症し,診断・治療に難渋した重症ACTH依存性クッシング症候群の一例

手塚雄太, 森本玲, 工藤正孝, 小野美澄, 岩倉芳倫, 五十嵐康宏, 清治和将, 高瀬圭, 福原紀章, 堀口健太郎, 西岡宏, 山田正三, 伊藤貞嘉, 佐藤文俊

間脳・下垂体・副腎系研究会プログラム・抄録集　27th　14-32　2016/03/12
Publisher: 間脳・下垂体・副腎系研究会
ISSN： 1340-4512

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症例は62歳女性で、高血圧症は内服管理で良好であった。下腿浮腫、満月様顔貌が出現し、低K血症を指摘され、加療を開始したが改善なく、紹介受診した。精査で高血圧増悪、低K血症、代謝性アルカローシスを指摘された。CTで左副腎に長径20mmの結節を認め、高コルチゾール血症を伴うことからクッシング症候群と診断された。ペラミビルを開始し、同時にメチラポンを開始し背景にある高コルチゾール血症の是正を図った。経蝶形骨洞下垂体手術を施行した。初診より13ヵ月後に両側副腎摘除術を施行した。病状は安定し、経過は良好である。
妊娠25週に自然破裂した腎血管筋脂肪腫に対して待機的に低線量率透視下経動脈的塞栓術を施行した1例

明円真吾, 三塚浩二, 村川裕希, 今野将人, 江里口智大, 方山博路, 佐竹洋平, 並木俊一, 齋藤英郎, 伊藤明宏, 荒井陽一, 大田英揮, 高瀬圭

泌尿器外科　29　(2)　189　2016/02/15

ISSN： 0914-6180
MRIの保有状況と利用に関する全国調査

佐藤美帆, 町田好男, 別所俊一郎, 稲葉洋平, 高瀬圭

日本放射線技術学会総会学術大会予稿集　72回　267-267　2016/02
Publisher: (公社)日本放射線技術学会
ISSN： 1884-7846
動脈塞栓術にて止血し得た膵仮性嚢胞内出血によるhemosuccus pancreaticusの1例

相澤卓, 前田晋平, 唐澤秀明, 石田晶玄, 深瀬耕二, 水間正道, 坂田直昭, 大塚英郎, 森川孝則, 中川圭, 林洋毅, 菅野敦, 元井冬彦, 内藤剛, 高瀬圭, 海野倫明

日本腹部救急医学会雑誌　36　(2)　478-478　2016/02
Publisher: (一社)日本腹部救急医学会
ISSN： 1340-2242
卵巣原発が疑われる類上皮血管肉腫の1例

高橋祐輝, 松浦智徳, 大村健介, 前川由依, 野村脩子, 加賀谷由里子, 長谷川哲也, 木下知, 佐谷望, 佐藤嘉尚, 越智純子, 嶋内亜希子, 森菜緒子, 大田英揮, 北見昌広, 常陸真, 冨永循哉, 清治和将, 田村亮, 高瀬圭, 高橋昭喜, 新倉仁, 八重樫伸生

Japanese Journal of Radiology　34　(Suppl.)　2-2　2016/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
異所性胸腺腫の1例

佐藤嘉尚, 冨永循哉, 高橋祐輝, 大村健介, 前川由依, 野村脩子, 加賀谷由里子, 長谷川哲也, 木下知, 佐谷望, 越智純子, 嶋内亜希子, 森菜緒子, 松浦智徳, 大田英揮, 北見昌広, 常陸真, 清治和将, 田村亮, 高瀬圭, 高橋昭喜, 佐渡哲, 齋藤涼子

Japanese Journal of Radiology　34　(Suppl.)　3-3　2016/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
短期間に腹部内臓動脈病変による出血を繰り返しsegmental arterial mediolysis(SAM)が疑われた1例

長谷川哲也, 清治和将, 高橋祐輝, 大村健介, 前川由依, 野村脩子, 加賀谷由里子, 木下知, 佐谷望, 佐藤嘉尚, 松浦智徳, 大田英揮, 常陸真, 冨永循哉, 田村亮, 高瀬圭, 高橋昭喜, 高木英誠

Japanese Journal of Radiology　34　(Suppl.)　3-3　2016/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
側頭葉てんかんの術前評価における海馬VolumetryとT2 Relaxometryの有用性

佐藤志帆, 麦倉俊司, 舘脇康子, 加藤裕美子, 村田隆紀, 高瀬圭, 高橋昭喜, 岩崎真樹, 冨永悌二, 神一敬, 中里信和, 鈴木博義

Japanese Journal of Radiology　34　(Suppl.)　11-11　2016/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
低血糖脳症の予後とMRI所見の検討

鈴木美樹子, 加藤裕美子, 舘脇康子, 村田隆紀, 麦倉俊司, 高瀬圭, 高橋昭喜, 栗原紀子

Japanese Journal of Radiology　34　(Suppl.)　14-14　2016/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
重症びまん性軸索損傷のマーカーとしての初回CTにおける正中くも膜下出血(Traumatic midline subarachnoid hemorrhages on initial CT as markers of severe diffuse axonal injury)

マタ・ムメンバ・ダディ, 麦倉俊司, 中川敦寛, 村田隆紀, 石井清, 久志本成樹, 冨永悌二, 高橋昭喜, 高瀬圭

日本脳神経外傷学会プログラム・抄録集　39回　86-86　2016/02
Publisher: (一社)日本脳神経外傷学会
心嚢液貯留に集積亢進を認めたFDG-PET/CTの1例

福永久典, 下村英雄, 舘脇康子, 寺尾千秋, 戸恒智子, 阿部十也, 武藤達士, 瀧靖之, 荒井晃, 高浪健太郎, 高瀬圭

核医学(Web)　53　(1)　2016

ISSN： 2189-9932
ニューモシスチス肺炎を発症し,診断・治療に難渋した重症ACTH依存性クッシング症候群の一例

手塚雄太, 森本玲, 工藤正孝, 小野美澄, 岩倉芳倫, 五十嵐康宏, 清治和将, 高瀬圭, 福原紀章, 堀口健太郎, 西岡宏, 山田正三, 伊藤貞嘉, 佐藤文俊

ACTH Related Peptides　27　30‐32　2016

ISSN： 1340-4512
【副腎の病理】原発性アルドステロン症を呈する副腎皮質病変の病理

小野美澄, 笹野公伸, 森本玲, 岩倉芳倫, 祢津昌広, 尾股慧, 手塚雄太, 五十嵐康宏, 工藤正孝, 清治和将, 山崎有人, 深谷佐智子, 中村保宏, 高瀬圭, 荒井陽一, 伊藤貞嘉, 佐藤文俊

病理と臨床　33　(12)　1309-1314　2015/12
Publisher: (株)文光堂
ISSN： 0287-3745
4D Flow MRIを用いた慢性血栓塞栓性肺高血圧症に対する経皮的肺動脈形成術前後の評価

大田英揮, 杉村宏一郎, 佐藤遥, 青木竜男, 建部俊介, 三浦正暢, 矢尾板信裕, 下川宏明, 高瀬圭

日独医報　60　(2)　239　2015/11/25

ISSN： 0912-0351
食道癌化学放射線療法における心臓照射線量と心筋脂肪酸代謝障害の関連 BMIPP SPECT/CTによる経時的評価

高浪健太郎, 荒井晃, 梅澤玲, 角谷倫之, 竹内孝至, 神宮啓一, 高瀬圭

日独医報　60　(2)　240-240　2015/11
Publisher: バイエル薬品(株)
ISSN： 0912-0351
腹部急性大動脈症候群大動脈瘤破裂・切迫破裂 Invited

高木英誠, 大田英揮, 津田雅視, 高瀬圭

臨床放射線　60　(11)　1774-1780　2015/11

ISSN： 0009-9252
神経線維腫症1型に合併した椎骨動脈破裂の一例

高木英誠, 大田英揮, 村田隆紀, 橋本宗敬, 後藤均, 高瀬圭

日独医報　60　(2)　226-226　2015/11
Publisher: バイエル薬品(株)
ISSN： 0912-0351
Association between radiation dosimetry of the heart and the myocardial fatty acid metabolic impairment due to chemoradiation-therapy : Prospective study using I-123 BMIPP SPECT/CT

K. Takanami, R. Umezawa, N. Kadoya, A. Arai, K. Jingu, K. Takase

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　42　S284-S285　2015/10

ISSN： 1619-7070

eISSN： 1619-7089
脳死小腸移植後中心静脈アクセス困難例に対し、CTガイド下留置術を施行した1例

山木聡史, 和田基, 工藤博典, 佐々木英之, 風間理郎, 田中拡, 中村恵美, 鹿股利一郎, 渡邊智彦, 大田英揮, 高瀬圭, 仁尾正記

移植　50　(4-5)　449-449　2015/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947
今、イメージングで見えているものは何か? 医療現場での未来の応用を考える造影超音波定量解析による乳癌早期リンパ節転移診断

森菜緒子, 嶋内亜希子, 宮下穣, 石田孝宣, 伊藤康一, 工藤由美子, 三木美香, 小玉哲也, 高瀬圭

日本癌学会総会記事　74回　S4-6　2015/10
Publisher: 日本癌学会
ISSN： 0546-0476
原発性アルドステロン症診療の問題点ガイドラインと実地診療時間的及び経済的に効率的な原発性アルドステロン症の診療を考えるスクリーニングからサブタイプ診断まで

佐藤文俊, 森本玲, 小野美澄, 岩倉芳倫, 袮津昌広, 尾股慧, 手塚雄太, 工藤正孝, 清治和將, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　38回　245-245　2015/10
Publisher: (NPO)日本高血圧学会
血漿アルドステロン及び活性型レニン濃度迅速測定系を用いた原発性アルドステロン症診断の研究

小野美澄, 森本玲, 岩倉芳倫, 手塚雄太, 五十嵐康宏, 工藤正孝, 祢津昌広, 清治和将, 中村保宏, 笹野公伸, 荒井陽一, 高瀬圭, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　38回　390-390　2015/10
Publisher: (NPO)日本高血圧学会
原発性アルドステロン症患者の下部尿路症状の評価

川崎芳英, 海法康裕, 伊藤明宏, 川守田直樹, 山下慎一, 石戸谷滋人, 森本玲, 高瀬圭, 荒井陽一

日本排尿機能学会誌　26　(1)　155-155　2015/09
Publisher: (一社)日本排尿機能学会
ISSN： 1347-6513
アルドステロン・コルチゾール分泌異常の新展開原発性アルドステロン症診断の新展開時間とコストを節約する新規デバイスと病理診断

佐藤文俊, 森本玲, 小野美澄, 岩倉芳倫, 祢津昌広, 尾股慧, 手塚雄太, 五十嵐康宏, 工藤正孝, 清治和将, 高瀬圭, 中村保宏, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　91　(2)　548-548　2015/09
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
乳頭状腎細胞癌のsubtypeに対する造影CTのヒストグラム解析

田村亮, 松浦智徳, 大田英揮, 清治和将, 高瀬圭, 荒井陽一, 笹野公伸

東北医学雑誌　127　(1)　74　2015/06/25

ISSN： 0040-8700
Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus surgery-first for resectable pancreatic carcer (Prep-02/JSAP05).

Michiaki Unno, Fuyuhiko Motoi, Tomoo Kosuge, Hideki Ueno, Hiroki Yamaue, Sohei Satoi, Masayuki Sho, Goro Honda, Ippei Matsumoto, Keita Wada, Junji Furuse, Tohru Furukawa, Kazuyuki Ishida, Kei Takase, Yutaka Matsuyama, Kei Nakagawa, Yu Katayose

JOURNAL OF CLINICAL ONCOLOGY　33　(15)　2015/05

ISSN： 0732-183X

eISSN： 1527-7755
乳癌内微小環境の観察

工藤由美子, 三木未佳, 船水康陽, 三木俊, 森菜緒子, 嶋内亜希子, 高瀬圭, 宮下穣, 笠島敦子

超音波医学　42　(3)　369-370　2015/05
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
テタニーを契機に診断された、ビタミンD欠乏合併原発性アルドステロン症の1例

村上隆亮, 加藤朋子, 松田優樹, 南部拓央, 米光新, 武呂誠司, 隠岐尚吾, 森本玲, 佐藤文俊, 伊藤貞嘉, 清治和将, 高瀬圭

日本内分泌学会雑誌　91　(1)　359-359　2015/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
IN PRIMARY ALDOSTERONISM WITH BILATERAL ADRENAL ADNOMAS, LAPAROSCOPIC BILATERAL ADRENAL SURGERY COULD BE AN OPTIONAL TREATMENT UNDER SELECTIVE ADRENAL VENOUS SAMPLING

Yoshihide Kawasaki, Shigeto Ishidoya, Akihiro Ito, Yasuhiro Kaiho, Ryo Morimoto, Kei Takase, Yoichi Arai

JOURNAL OF UROLOGY　193　(4)　E81-E81　2015/04

ISSN： 0022-5347

eISSN： 1527-3792
副腎皮質腫瘍の診断と治療両側副腎病変に対する両側切除(一部温存)術後の残存副腎機能の検討

川崎芳英, 海法康裕, 伊藤明宏, 石戸谷滋人, 森本玲, 佐藤文俊, 高瀬圭, 荒井陽一

日本内分泌・甲状腺外科学会雑誌　32　(Suppl.1)　S73-S73　2015/04
Publisher: 日本内分泌外科学会・日本甲状腺外科学会
ISSN： 2186-9545
難治性副腎疾患の研究と診断の進歩アルドステロン産生腺腫の診断と治療のNew Method

佐藤文俊, 森本玲, 小野美澄, 岩倉芳倫, 尾股慧, 祢津昌広, 工藤正孝, 清治和将, 高瀬圭, 中村保宏, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　91　(1)　185-185　2015/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
超音波による腎動脈病変の標準的評価法

廣岡芳樹, 松尾汎, 阿部倫明, 岩嶋義雄, 小田代敬太, 佐藤洋, 高瀬圭, 平井都始子, 松村誠, 三木俊, 日本超音波医学会用語, 診断基準委員会, 腎動脈超音波診断ガイドライン小委員会

超音波医学　42　(2)　185-200　2015/03
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
興味深い経過をたどった筋腫合併子宮憩室の1例

長谷川哲也, 松浦智徳, 清治和将, 高澤千晶, 森菜緒子, 大田英揮, 常陸真, 冨永循哉, 負門克典, 田村亮, 高瀬圭, 高橋昭喜, 佐藤いずみ, 豊島将文, 永瀬智, 八重樫伸生

Japanese Journal of Radiology　33　(Suppl.)　3-3　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
アルドステロン産生腫瘍と周囲臓器・組織との位置関係に関する考察原発性アルドステロン症に対する新しいRFA治療に向けて

木下知, 清治和将, 松浦智徳, 高澤千晶, 森菜緒子, 大田英揮, 常陸真, 冨永循哉, 負門克典, 田村亮, 高橋昭喜, 高瀬圭, 佐藤文俊, 森本玲

Japanese Journal of Radiology　33　(Suppl.)　7-7　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
産褥心筋症の1例

長谷川哲也, 大田英揮, 高澤千晶, 森菜緒子, 嶋内亜希子, 松浦智徳, 常陸真, 冨永循哉, 負門克典, 清治和将, 田村亮, 高瀬圭, 高橋昭喜

Japanese Journal of Radiology　33　(Suppl.)　10-10　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
腫瘍との鑑別が困難であった腫瘤形成性慢性膵炎の1例

佐谷望, 松浦智徳, 高澤千晶, 森菜緒子, 大田英揮, 常陸真, 冨永循哉, 負門克典, 清治和将, 田村亮, 高瀬圭, 高橋昭喜

Japanese Journal of Radiology　33　(Suppl.)　11-11　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
中年男性に発症したSolid pseudopapillary neoplasmの1例

高橋紀善, 田村亮, 木下知, 長谷川哲也, 及川朋美, 高澤千晶, 森奈緒子, 嶋内亜希子, 松浦智徳, 大田英揮, 常陸真, 富永循哉, 負門克典, 清治和将, 高瀬圭, 高橋昭喜, 藤島史喜

Japanese Journal of Radiology　33　(Suppl.)　11-11　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
頭蓋骨に発生した傍骨性骨肉腫の1例

及川朋美, 常陸真, 長谷川哲也, 館脇康子, 李麗, 麦倉俊司, 高澤千晶, 森菜緒子, 松浦智徳, 大田英揮, 冨永循哉, 負門克典, 清治和将, 田村亮, 高瀬圭, 高橋昭喜, 遠藤俊毅, 綿貫宗則, 保坂正美, 渡邊みか

Japanese Journal of Radiology　33　(Suppl.)　1-1　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
原発性アルドステロン症患者における夜間頻尿の検討

川崎芳英, 伊藤明宏, 海法康裕, 森本玲, 高瀬圭, 石戸谷滋人, 荒井陽一

日本泌尿器科学会東部総会プログラム・抄録集　80th　264　2015
繰り返す腎血管筋脂肪腫の腫瘍内出血の末に両側腎摘出術に至った結節性硬化症の1症例

米谷重俊, 川崎芳英, 三塚浩二, 大田英揮, 松浦智徳, 清治和将, 高瀬圭, 荒井陽一

泌尿器画像診断・治療技術研究会プログラム・抄録　3rd　50　2015
胸部大動脈瘤術後の大動脈径変化へのカンデサルタンによる影響 CAPTAIN study中間報告

片平晋太郎, 熊谷紀一郎, 佐々木康之輔, 鈴木満里奈, 川本俊輔, 齋木佳克, 大田英揮, 高瀬圭, 菅原由美, 辻一郎, 永谷公一, 長嶺進, 三浦誠, 高橋悟朗, 篠崎滋, CAPTAIN study group

日本心臓血管外科学会雑誌　44　(Suppl.)　341-341　2015/01
Publisher: (NPO)日本心臓血管外科学会
ISSN： 0285-1474
MR imaging of subcallosal artery infarct causing amnesia after surgery for anterior communicating artery aneurysm

S. Mugikura, S. Mugikura, H. Kikuchi, T. Fujii, T. Murata, K. Takase, E. Mori, S. Marinković, S. Takahashi

American Journal of Neuroradiology　35　2293-2301　2014/12/01

DOI： 10.3174/ajnr.A4057 　

ISSN： 0195-6108
【高血圧をめぐる最新の話題】臨床二次性高血圧原発性アルドステロン症

佐藤文俊, 森本玲, 岩倉芳倫, 小野美澄, 祢津昌広, 松田謙, 尾股慧, 工藤正孝, 高瀬圭, 中村保宏, 笹野公伸, 伊藤貞嘉

最新医学　69　(11月増刊)　2389-2398　2014/11
Publisher: (株)最新医学社
ISSN： 0370-8241
超高齢者に発症した肝血管腫自然破裂の1救命例

志村充広, 水間正道, 岡田良, 阿部友哉, 谷口肇, 岡田恭穂, 益田邦洋, 深瀬耕二, 元井冬彦, 内藤剛, 片寄友, 高瀬圭, 海野倫明

日本臨床外科学会雑誌　75　(増刊)　482-482　2014/10
Publisher: 日本臨床外科学会
ISSN： 1345-2843
原発性アルドステロン症における眼底血流評価の臨床的意義について

工藤正孝, 國方彦志, 相澤奈帆子, 麦倉俊司, 新田文彦, 小野美澄, 岩倉芳倫, 尾股慧, 森本玲, 清治和将, 高瀬圭, 高橋秀肇, 中澤徹, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　37回　368-368　2014/10
Publisher: (NPO)日本高血圧学会
微小腺腫を含むアルドステロン産生腺腫におけるCYP11B1、CYP11B2発現の臨床病理学的検討

小野美澄, 中村保宏, 前川尚志, 森本玲, 岩倉芳倫, 尾股慧, 祢津昌広, 工藤正孝, 清治和将, 高瀬圭, 荒井陽一, Gomez-Sanchez Celso E, 伊藤貞嘉, 笹野公伸, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　37回　394-394　2014/10
Publisher: (NPO)日本高血圧学会
原発性アルドステロン症の新規病理鑑別診断とステロイド合成の病態生理

佐藤文俊, 小野美澄, 森本玲, 岩倉芳倫, 尾股慧, 工藤正孝, 清治和将, 高瀬圭, 中村保宏, 土居雅夫, 岡村均, 笹野公伸, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　37回　394-394　2014/10
Publisher: (NPO)日本高血圧学会
初期の病理組織標本が得られた強皮症関連間質性肺炎の1例

佐藤嘉尚, 冨永循哉, 佐谷望, 負門克典, 高瀬圭, 大河内眞也, 齊藤涼子

日本医学放射線学会秋季臨床大会抄録集　50th　S713　2014/09/05

ISSN： 0048-0428
Novel Pathological Diagnosis Between Aldosterone Producing Adenoma And Idiopathic Hyperaldosteronism

Fumitoshi Satoh, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Kei Omata, Kazumasa Seiji, Kei Takase, Yasuhiro Nakamura, Masao Doi, Hitoshi Okamura, Celso Gomez-Sanchez, Hironobu Sasano, Sadayoshi Ito

HYPERTENSION　64　2014/09

ISSN： 0194-911X

eISSN： 1524-4563
再発性、多発性の心臓粘液腫を呈したCarney complexの一例

高木英誠, 大田英揮, 渡辺みか, 高瀬圭, 齋木佳克, 高橋昭喜

日独医報　59　(2)　279-279　2014/09
Publisher: バイエル薬品(株)
ISSN： 0912-0351
胸腹部大動脈手術後いかに脊髄虚血合併症を避けるか:最新のコンセプト,技術,および放射線イメージング

高木英誠, 大田英揮, 伊藤校輝, 高瀬圭, 齋木佳克, 高橋昭喜

東北医学雑誌　126　(1)　97　2014/06/25

ISSN： 0040-8700
Histopathology and Steroidogenesis of Microadenomas Associated with Primary Aldosteronism

Yoshikiyo Ono, Yasuhiro Nakamura, Ryo Morimoto, Yoshitsugu Iwakura, Masahiro Nezu, Kei Omata, Ken Matsuda, Masataka Kudo, Takashi Maekawa, Saulo J. A. Felizola, Kazumasa Seiji, Kei Takase, Yoichi Arai, Celso E. Comez-Sanchez, Hironobu Sasano, Sadayoshi Ito, Fumitoshi Satoh

ENDOCRINE REVIEWS　35　(3)　2014/06

ISSN： 0163-769X

eISSN： 1945-7189
先天性門脈体循環短絡症に対してコイル塞栓を施行した3歳女児例

木村正人, 佐藤信一, 高瀬圭, 和田基, 坂本修, 呉繁夫

日本小児放射線学会雑誌　30　39　2014/06/01

ISSN： 0918-8487
64列MDCT angiographyと3T MR angiographyを用いたAdamkiewicz動脈の術前同定

高木英誠, 大田英揮, 高瀬圭, 齋木佳克, 高橋昭喜

日独医報　59　(1)　113-113　2014/06
Publisher: バイエル薬品(株)
ISSN： 0912-0351
心臓MRI検査を用いた放射線治療後の心筋変化の検出

梅澤玲, 高瀬圭, 大田英揮, 高浪健太郎, 金田朋洋, 神宮啓一, 高橋昭喜

日独医報　59　(1)　114-114　2014/06
Publisher: バイエル薬品(株)
ISSN： 0912-0351
【腹部の最新画像情報2014】出血を伴う嚢胞状病変を呈し、術前診断が困難であった膵腺房細胞癌の1例

森菜緒子, 松浦智徳, 大田英揮, 常陸真, 清治和将, 田村亮, 高瀬圭, 高橋昭喜

臨床放射線　59　(6)　822-827　2014/06
Publisher: 金原出版(株)
ISSN： 0009-9252

More details Close

症例は50歳代の男性で、急性膵炎後に指摘された膵頭部腫瘤の精査目的で当院紹介となった。初診時のUSでは径35mmの低エコー腫瘤を認めたが、約1ヵ月後のCTで病変は20mmと前医CT所見より縮小していた。急性膵炎に伴う仮性嚢胞として経過観察を行ったところ、1年後の造影EUSで造影効果を認め、充実性腫瘍が疑われた。その後、持続性の上腹部痛を認め入院となり、MRIやPET/CT所見、臨床経過からacinar cell carcinomaなどを疑い、1年4ヵ月の経過で膵頭十二指腸切除術が施行された。病理組織学的に膵頭部腺房細胞癌であった。
超音波による腎動脈病変の標準的評価法(案)

廣岡芳樹, 松尾汎, 阿部倫明, 岩嶋義雄, 小田代敬太, 佐藤洋, 高瀬圭, 平井都始子, 松村誠, 三木俊, 日本超音波医学会用語, 診断基準委員会, 腎動脈超音波診断ガイドライン小委員会

超音波医学　41　(3)　389-404　2014/05
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
副腎静脈サンプリングにおいて左下横隔静脈または左腎被膜静脈からの採血が局在診断に有用であった症例

清治和将, 高瀬圭, 田村亮, 冨永循哉, 常陸真, 大田英揮, 松浦智徳, 木下知, 長谷川哲也, 高木英誠, 小野美澄, 岩倉芳倫, 森本玲, 佐藤文俊, 高橋昭喜

IVR: Interventional Radiology　29　(Suppl.)　284-284　2014/05
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
当院における産褥晩期出血の検討

長谷川哲也, 清治和将, 高木英誠, 大田英揮, 松浦智徳, 常陸真, 冨永循哉, 田村亮, 高瀬圭, 高橋昭喜, 杉山隆, 新倉仁

IVR: Interventional Radiology　29　(Suppl.)　313-313　2014/05
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
原発性アルドステロン症の診断と治療高齢アルドステロン症患者に対する腹腔鏡下副腎摘除術

川崎芳英, 海法康裕, 石戸谷滋人, 森本玲, 佐藤文俊, 高瀬圭, 荒井陽一

日本内分泌・甲状腺外科学会雑誌　31　(Suppl.1)　S72-S72　2014/04
Publisher: 日本内分泌外科学会・日本甲状腺外科学会
ISSN： 2186-9545
原発性アルドステロン症のIVR治療に向けての基礎的検討バイポーラーアブレーション針を用いた副腎腺腫焼灼術に向けて

高瀬圭, 清治和将, 佐藤文俊, 森本玲, 小野美澄, 岩倉芳倫, 伊藤貞嘉, 高橋昭喜

日本内分泌学会雑誌　90　(1)　326-326　2014/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
必ず成功させる副腎静脈サンプリングの方法論 MDCTによる右副腎静脈描出と5つのカテーテル

佐藤文俊, 高瀬圭, 森本玲, 工藤正孝, 岩倉芳倫, 小野美澄, 松田謙, 祢津昌広, 尾股慧, 清治和将, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　90　(1)　282-282　2014/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
アルドステロン研究Update 原発性アルドステロン症Update 臨床診断と病理診断の進歩

佐藤文俊, 森本玲, 工藤正孝, 岩倉芳倫, 小野美澄, 尾股慧, 高瀬圭, 清治和将, 土居雅夫, 岡村均, 中村保宏, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　90　(1)　161-161　2014/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
small size APAにおけるCYP11B1およびCYP11B2発現の特徴

小野美澄, 中村保宏, 前川尚志, 森本玲, 岩倉芳倫, 松田謙, 工藤正孝, 祢津昌広, 尾股慧, 清治和将, 高瀬圭, 荒井陽一, Gomez-Sanchez Celso E, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　90　(1)　326-326　2014/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
術前CTで診断し得た大網裂孔ヘルニアの1例

高木英誠, 大田英揮, 高澤千晶, 森奈緒子, 松浦智徳, 常陸真, 冨永循哉, 清治和将, 田村亮, 高瀬圭, 高橋昭喜, 関口悟, 浅野直喜

Japanese Journal of Radiology　32　(Suppl.)　2-2　2014/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
中手骨に発生した骨肉腫の1例

佐藤志帆, 常陸真, 高澤千晶, 森菜緒子, 松浦智徳, 大田英揮, 冨永循哉, 清治和将, 高瀬圭, 高橋昭喜, 保坂正美, 綿貫宗則, 渡邉みか

Japanese Journal of Radiology　32　(Suppl.)　3-3　2014/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
意識消失発作で発症した再発腎癌の1例

田村亮, 松浦智徳, 大田英揮, 常陸真, 冨永循哉, 清治和将, 高瀬圭, 高橋昭喜

Japanese Journal of Radiology　32　(Suppl.)　11-11　2014/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
Schmorl結節を合併した形質細胞腫の1例

佐藤志帆, 常陸真, 麦倉俊司, 高澤千晶, 森菜緒子, 松浦智徳, 大田英揮, 冨永循哉, 清治和将, 田村亮, 高瀬圭, 高橋昭喜

Japanese Journal of Radiology　32　(Suppl.)　15-15　2014/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
類骨骨腫のRFA前後の画像所見

佐谷望, 常陸真, 高澤千晶, 森菜緒子, 松浦智徳, 大田英揮, 冨永循哉, 清治和将, 田村亮, 高瀬圭, 高橋昭喜, 加藤健一, 江原茂

Japanese Journal of Radiology　32　(Suppl.)　15-15　2014/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
治療に難渋したFMDの1例

長谷川哲也, 大田英揮, 松浦智徳, 常陸真, 冨永循哉, 清治和将, 田村亮, 高瀬圭, 高橋昭喜, 鈴木健弘, 阿部高明

Japanese Journal of Radiology　32　(Suppl.)　15-15　2014/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
副腎部分切除術~adrenal‐sparing surgery~の可能性の探索

石戸谷滋人, 川崎芳英, 海法康裕, 荒井陽一, 高瀬圭

泌尿器画像診断・治療技術研究会プログラム・抄録　2nd　25　2014
呼吸によるCT urographyへの影響:吸気撮影と尿管屈曲との関連

松浦智徳, 田村亮, 大田英揮, 清治和将, 高瀬圭

泌尿器画像診断・治療技術研究会プログラム・抄録　2nd　55　2014
Hemorrhagic cystic lesion of pancreatic head: A case of acinar cell carcinoma which was difficult to diagnose preoperatively

Naoko Mori, T. Matsuura, H. Ota, S. Hitachi, K. Seiji, R. Tamura, K. Takase, S. Takahashi

Japanese Journal of Clinical Radiology　59　822-827　2014/01/01

ISSN： 0009-9252
副腎静脈サンプリングを考える：東北大学病院 Invited

森本玲, 清治和将, 伊藤貞嘉, 高瀬圭, 佐藤文俊

ホルモンと臨床　62　(6)　443-449　2014
副腎ホルモン産生異常に関する調査研究 17.small size APAにおけるCYP11B1およびCYP11B2発現の特徴

小野美澄, 岩倉芳倫, 森本玲, 祢津昌広, 松田謙, 工藤正孝, 尾股慧, 伊藤貞嘉, 佐藤文俊, 中村保宏, 笹野公伸, 高瀬圭, 清治和将, 荒井陽一

副腎ホルモン産生異常に関する調査研究平成25年度総括・分担研究報告書　182　2014
副腎ホルモン産生異常に関する調査研究原発性アルドステロン症の病態に関する研究「small size APAにおけるCYP11B1およびCYP11B2発現の特徴」に関する研究

佐藤文俊, 小野美澄, 森本玲, 岩倉芳倫, 祢津昌広, 松田謙, 尾股慧, 工藤正孝, 伊藤貞嘉, 中村保宏, 笹野公伸, 高瀬圭, 清治和将, 荒井陽一

副腎ホルモン産生異常に関する調査研究平成25年度総括・分担研究報告書　107-109　2014
SLE加療中、片側副腎腫瘍を指摘、治療選択に苦慮したPAの一例

小野美澄, 岩倉芳倫, 森本玲, 松田謙, 祢津昌広, 尾股慧, 清治和将, 高瀬圭, 中村やすひろ, 高橋昭喜, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　89　(3)　958-958　2013/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
原発性アルドステロン症の診断治療Update

森本玲, 工藤正孝, 岩倉芳倫, 松田謙, 小野美澄, 祢津昌広, 尾股慧, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　89　(3)　887-887　2013/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
【解剖がわかれば走査がわかる決定版超音波検査テクニックマスター腹部・下肢編】 (第3章)症例編膝窩動脈外膜嚢腫・膝窩動脈捕捉症候群

高木英誠, 高瀬圭

Vascular Lab　10　(増刊)　226-231　2013/10
Publisher: (株)メディカ出版
ISSN： 1349-4023
原発性副甲状腺機能亢進症の術後に心不全を呈し、心臓にび漫性の石灰化を認めた1例

高木英誠, 大田英揮, 青木竜夫, 杉村宏一郎, 福本義宏, 高瀬圭, 下川宏明, 高橋昭喜

日独医報　58　(1)　135-136　2013/10
Publisher: バイエル薬品(株)
ISSN： 0912-0351
FDG-PETで集積が見られた胸椎骨棘近傍線維化の2症例

負門克典, 冨永循哉, 高浪健太郎, 金田朋洋, 高瀬圭, 高橋昭喜

肺癌　53　(5)　506-506　2013/10
Publisher: (NPO)日本肺癌学会
ISSN： 0386-9628
Measurement of Peripheral Blood 18-Oxocortisol as the Diagnostic Method of Primary Aldosteronism and Its Subtypes

Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Ken Matsuda, Kei Takase, Celso E. Gomez-Sanchez, William E. Rainey, Hironobu Sasano, Yoshihiro Nakamura, Sadayoshi Ito

HYPERTENSION　62　(3)　2013/09

ISSN： 0194-911X

eISSN： 1524-4563
水腎症を契機に発見されたintrinsic typeの尿管子宮内膜症の1例

松浦智徳, 清治和将, 松永賢一, 間島一浩, 大田英揮, 田村亮, 高瀬圭, 松岡俊光, 細井隆之, 金彰午, 高橋昭喜

日本医学放射線学会秋季臨床大会抄録集　49回　S555-S555　2013/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
乳腺良悪性境界病変のMRIとその意義

森菜緒子, 高澤千晶, 松浦智徳, 大田英揮, 常陸真, 冨永循哉, 清治和将, 田村亮, 高瀬圭, 高橋昭喜

日本医学放射線学会秋季臨床大会抄録集　49回　S576-S576　2013/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
気管Glomus腫瘍の1例

木下知, 冨永循哉, 負門克典, 大田英揮, 松浦智徳, 金田朋洋, 高瀬圭, 高橋昭喜, 中村保宏, 遠藤千顕

日本医学放射線学会秋季臨床大会抄録集　49回　S598-S598　2013/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
術後8年の経過を経て対側副腎に再発を認めた原発性アルドステロン症の一例

松田謙, 工藤正孝, 小野美澄, 岩倉芳倫, 祢津昌広, 森本玲, 清治和将, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　2回　166-166　2013/05
Publisher: (NPO)日本高血圧学会
副腎腫瘍の良悪性と臨床予後は現在どこまで判るのか? 画像診断でどこまで判るのか?

清治和将, 高瀬圭, 高橋昭喜, 荒井陽一, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　89　(1)　164-164　2013/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
原発性アルドステロン症の画像診断と副腎静脈サンプリング

高瀬圭, 清治和将, 佐藤文俊, 森本玲, 大田英揮, 伊藤貞嘉, 高橋昭喜

日本内分泌学会雑誌　89　(1)　209-209　2013/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
外傷のIVRを考える高度救命救急センターにおける緊急IVR症例から考える処置中のリスクマネジメント

佐藤武揚, 高瀬圭, 清治和将, 高橋昭喜, 久志本成樹

IVR: Interventional Radiology　28　(Suppl.)　91-91　2013/04
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
肝動脈塞栓術により救命しえた肝被膜下血腫を来したHELLP症候群の1例

田村亮, 高瀬圭, 清治和将, 大田英揮, 松浦智徳, 常陸真, 高橋昭喜

IVR: Interventional Radiology　28　(Suppl.)　157-157　2013/04
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
治療に難渋した腎動脈線維筋性異形性の1例

清治和将, 長谷川哲也, 松浦智徳, 大田英揮, 常陸真, 冨永循哉, 田村亮, 高瀬圭, 高橋昭喜, 鈴木健弘, 阿部高明

IVR: Interventional Radiology　28　(Suppl.)　207-207　2013/04
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
EVAR後Type II endoleakに対する治療戦略

深山紀幸, 佐藤成, 後藤均, 橋本宗敬, 赤松大二朗, 清水拓也, 土田憲, 高瀬圭, 清治和将, 大田英揮, 大内憲明

日本血管外科学会雑誌　22　(2)　455-455　2013/04
Publisher: (NPO)日本血管外科学会
ISSN： 0918-6778
コイル塞栓にて治療した大動脈人工血管置換術後吻合部リークの1例

高瀬圭, 大田英揮, 佐藤嘉尚, 清治和将, 津田雅視, 常陸真, 松浦智徳, 高橋昭喜, 斎木佳克, 後藤均, 佐藤成

IVR: Interventional Radiology　28　(Suppl.)　184-184　2013/04
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
原発性アルドステロン症診断・治療の問題点効率的スクリーニングと地域連携

佐藤文俊, 森本玲, 工藤正孝, 岩倉芳倫, 松田謙, 小野美澄, 祢津昌広, 清治和将, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　89　(1)　172-172　2013/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
臨床アウトカムから検証するAVSを巡る諸課題に対するアプローチ PA Sendai Studyレジストリーの検討

森本玲, 工藤正孝, 岩倉芳倫, 松田謙, 小野美澄, 祢津昌広, 中村保宏, 清治和将, 高瀬圭, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　89　(1)　209-209　2013/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
アルドステロン産生微小腺腫における免疫組織化学的検討

小野美澄, 中村保宏, 森本玲, 岩倉芳倫, 祢津昌広, 松田謙, 工藤正孝, 清治和将, 高瀬圭, 前川尚志, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　89　(1)　226-226　2013/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
経皮的椎体形成術後の続発性骨折の検討

鈴木雅也, 常陸真, 松浦智徳, 大田英揮, 清治和将, 津田雅視, 高瀬圭, 高橋昭喜

Japanese Journal of Radiology　31　(Suppl.I)　8-8　2013/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
冠動脈疾患を有する患者群における、頸動脈プラーク性状の人種差

大田英揮, DeMarco J. Kevin, Zhu David C, 高瀬圭, 高橋昭喜

日独医報　57　(2)　211-211　2013/02
Publisher: バイエル薬品(株)
ISSN： 0912-0351
副腎静脈の非造影MR venography 副腎静脈血サンプリングの術前検査として

佐谷望, 大田英揮, 清治和将, 高瀬圭, 高橋昭喜, 木村智圭, 永坂竜男

日本医学放射線学会学術集会抄録集　72回　S196-S196　2013/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
経皮的椎体形成術後の続発性骨折の検討

常陸真, 鈴木雅也, 松浦智徳, 大田英揮, 冨永循哉, 清治和将, 田村亮, 高瀬圭, 高橋昭喜

日本医学放射線学会学術集会抄録集　72回　S310-S310　2013/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
腎類上皮性血管筋脂肪腫の2例

松浦智徳, 清治和将, 田村亮, 高瀬圭, 中村保宏, 深谷佐智子, 渡辺みか, 斎藤英郎, 伊藤明宏, 荒井陽一, 高橋昭喜

泌尿器画像診断・治療技術研究会プログラム・抄録　1st　63　2013
Measurement of Peripheral Blood 18-Oxo-Cortisol Levels Can Discriminate Surgically Curable Primary Aldosteronism Among Hypertensive Patients, Omitting Many Steps of Diagnostic Workup

Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Yoshikiyo Ono, Ken Matsuda, Kazumasa Seiji, Kei Takase, Hironobu Sasano, Yasuhiro Nakamura, Sadayoshi Ito

AMERICAN JOURNAL OF HYPERTENSION　25　(12)　1318-1319　2012/12

ISSN： 0895-7061
Cardiac output obtained from test bolus injections as a factor in contrast injection rate revision of following coronary CT angiography

Masahiko Konno, Masahiko Konno, Yoshiyuki Hosokai, Akihito Usui, Mitsuya Abe, Toshiki Tateishi, Yusuke Kawasumi, Masashi Tsuda, Hideki Ota, Kei Takase, Haruo Saito

Acta Radiologica　10　(1258)　1-5　2012/12/01

DOI： 10.1258/ar.2012.120276 　

ISSN： 0284-1851
原発性アルドステロン症の治療正確な局在診断と外科治療

佐藤文俊, 森本玲, 工藤正孝, 岩倉芳倫, 小野美澄, 高瀬圭, 中村保宏, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　88　(3)　973-973　2012/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
単副腎に再発したPAの一例超選択的AVSと正常副腎温存手術の意義

小野美澄, 岩倉芳倫, 森本玲, 祢津昌広, 松田謙, 工藤正孝, 清治和将, 高瀬圭, 石戸谷滋人, 中村保宏, 荒井陽一, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　88　(3)　1007-1007　2012/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
栄養動脈塞栓術の上、腫瘍摘出手術に挑んだ巨大傍神経節種の1例

祢津昌広, 岩倉芳倫, 小野美澄, 松田謙, 森本玲, 工藤正孝, 清治和将, 高瀬圭, 関口悟, 中村保宏, 笹野公伸, 高畠恭介, 太田耕造, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　88　(3)　1008-1008　2012/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
超選択的AVSが治療方針決定に有用であったPAの一例

松田謙, 工藤正孝, 森本玲, 岩倉芳倫, 祢津昌広, 小野美澄, 清治和将, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　88　(3)　1028-1028　2012/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
原発性アルドステロン症における無症候性脳梗塞の合併を予測する新たなスコアの設定 CHA2DS2-VAScスコアとの比較検討

工藤正孝, 麦倉俊司, 小野美澄, 岩倉芳倫, 松田謙, 森本玲, 高瀬圭, 清治和将, 高橋昭喜, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　35回　392-392　2012/09
Publisher: (NPO)日本高血圧学会
脈管疾患の診療に直結する画像診断閉塞性動脈硬化症の画像診断

高瀬圭, 大田英揮, 高橋昭喜, 後藤均, 佐藤成

脈管学　52　(Suppl.)　S80-S80　2012/09
Publisher: (一社)日本脈管学会
ISSN： 0387-1126
原発性アルドステロン症screeningの際にレニンアンジオテンシン系阻害薬が与える影響当科自験296例の解析結果から

岩倉芳倫, 森本玲, 工藤正孝, 小野美澄, 松田謙, 高瀬圭, 清治和将, 石戸谷滋人, 荒井陽一, 中村保宏, 笹野公伸, 佐藤文俊, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　35回　452-452　2012/09
Publisher: (NPO)日本高血圧学会
手術及び術後ミトタン療法にて寛解を維持した性ホルモン産生副腎皮質癌の1剖検例

森本玲, 宮澤恵実子, 岩倉芳倫, 小野美澄, 祢津昌広, 松田謙, 工藤正孝, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　88　(2)　892-892　2012/09
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
超選択的副腎静脈採血に基づき片側副腎手術の適応と診断、寛解した両側副腎腫瘍を伴う重症クッシング症候群の一例

祢津昌広, 小野美澄, 松田謙, 岩倉芳倫, 森本玲, 工藤正孝, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　88　(2)　892-892　2012/09
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
原発性アルドステロン症の長期薬物治療経過中にクッシング徴候が顕在化した両側副腎腫瘍の一例

岩倉芳倫, 森本玲, 工藤正孝, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　88　(2)　893-893　2012/09
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
心筋脂肪酸シンチグラフィーによる照射野に含まれた心筋代謝変化に関する検討

梅澤玲, 高瀬圭, 高浪健太郎, 大田英揮, 神宮啓一, 金田朋洋, 高橋昭喜

日独医報　57　(1)　105　2012/08/03

ISSN： 0912-0351
EVAR後type II endoleakに対して、炭酸ガス造影超音波ガイド下に塞栓術を施行した1例

大田英揮, 高瀬圭, 佐藤志帆, 高橋昭喜, 赤松大二郎, 後藤均, 佐藤成

日独医報　57　(1)　108-108　2012/08
Publisher: バイエル薬品(株)
ISSN： 0912-0351
今月の症例 Segmental arterial mediolysis(SAM)

津田雅視, 高瀬圭, 高橋昭喜

臨床放射線　57　(5)　731-733　2012/05
Publisher: 金原出版(株)
ISSN： 0009-9252
左室流出路仮性瘤に対してコイル塞栓術を施行した3例

大田英揮, 松浦智徳, 常陸真, 清治和将, 津田雅視, 高瀬圭, 高橋昭喜, 熊谷紀一郎, 斎木佳克

IVR: Interventional Radiology　27　(2)　219-219　2012/05
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
経皮的椎体形成術後の続発性骨折の検討

鈴木雅也, 常陸真, 松浦智徳, 大田英揮, 清治和将, 津田雅視, 高瀬圭, 高橋昭喜

IVR: Interventional Radiology　27　(2)　220-220　2012/05
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
コイル塞栓にて治療した大動脈人工血管置換術後吻合部リークの1例

高瀬圭, 大田英揮, 佐藤嘉尚, 清治和将, 津田雅視, 常陸真, 松浦智徳, 高橋昭喜, 斎木佳克, 後藤均, 佐藤成

IVR: Interventional Radiology　27　(2)　219-219　2012/05
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
原発性アルドステロン症のupdate 原発性アルドステロン症の局在診断における副腎静脈サンプリングと末梢血18-oxo-cortisol

佐藤文俊, 森本玲, 工藤正孝, 岩倉芳倫, 小野美澄, 高瀬圭, 中村保宏, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　88　(1)　186-186　2012/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
アルドステロン産生微小腺腫の臨床的特徴についての検討

小野美澄, 森本玲, 岩倉芳倫, 工藤正孝, 高瀬圭, 石戸谷滋人, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　88　(1)　259-259　2012/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
アルドステロン産生腺腫の診断に於ける迅速ACTH負荷試験の有用性低レニン性本態性高血圧症との鑑別

森本玲, 工藤正孝, 岩倉芳倫, 小野美澄, 高瀬圭, 石戸谷滋人, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　88　(1)　300-300　2012/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
TEVAR術前の左鎖骨下動脈閉塞試験は有用か? 術後脳SPECTからの示唆

伊藤校輝, 熊谷紀一郎, 齋藤武志, 高瀬圭, 大田英揮, 松尾諭志, 早津幸弘, 鈴木佑輔, 渋谷拓見, 増田信也, 安達理, 秋山正年, 本吉直孝, 川本俊輔, 齋木佳克

日本心臓血管外科学会雑誌　41　(Suppl.)　524-524　2012/03
Publisher: (NPO)日本心臓血管外科学会
ISSN： 0285-1474
MDCT、MRIによる微細脈管構造描出・臨床応用および医療経済効果解析

高瀬圭, 李麗, 高橋昭喜

ナノ医工学年報　5　(1)　101-110　2012/03
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
Preliminary experience of laparoscopic simultaneous bilateral adrenalectomy for patients with aldosterone-producing adenoma

S. Ishidoya, A. Ito, Y. Kawasaki, M. Miyazato, Y. Kaiho, F. Satoh, R. Morimoto, K. Takase, Y. Arai

EUROPEAN UROLOGY SUPPLEMENTS　11　(1)　E1110-U309　2012/02

ISSN： 1569-9056
ビーグル成犬の外腸骨動脈における動脈瘤モデル作成法の検討

松永賢一, 高澤千晶, 清治和将, 高瀬圭, 高橋昭喜, 松橋俊夫

Japanese Journal of Radiology　30　(Suppl.I)　9-9　2012/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
0.052コイルによるPDA塞栓術

鈴木雅也, 高瀬圭, 津田雅視, 清治和将, 冨永循哉, 高橋昭喜, 小澤晃

Japanese Journal of Radiology　30　(Suppl.I)　12-12　2012/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
AVSにおける右副腎静脈カニュレーションの成功判定

森本玲, 佐藤文俊, 工藤正孝, 高瀬圭, 清治和将, 伊藤貞嘉

原発性アルドステロン症診断のための副腎静脈採血(AVS)のコツと判定法　21-24　2012
AVSにおける左副腎静脈のサンプリングポイントについて

工藤正孝, 佐藤文俊, 森本玲, 高瀬圭, 伊藤貞嘉

原発性アルドステロン症診断のための副腎静脈採血(AVS)のコツと判定法　25-29　2012
原発性アルドステロン症の長期薬物治療経過中にクッシング徴候が顕在化した両側副腎腫瘍の一例

岩倉芳倫, 森本玲, 工藤正孝, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌病理学会学術総会プログラム・抄録集　16th　15　2012
手術及び術後ミトタン療法にて寛解を維持した性ホルモン産生副腎皮質癌の1剖検例

森本玲, 宮澤恵実子, 岩倉芳倫, 小野美澄, 祢津昌広, 松田謙, 工藤正孝, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌病理学会学術総会プログラム・抄録集　16th　10　2012
超選択的副腎静脈採血に基づき片側副腎手術の適応と診断,寛解した両側副腎腫瘍を伴う重症クッシング症候群の一例

祢津昌広, 小野美澄, 松田謙, 岩倉芳倫, 森本玲, 工藤正孝, 高瀬圭, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌病理学会学術総会プログラム・抄録集　16th　14　2012
食道癌放射線治療後に放射線心筋障害が疑われた症例の画像所見

高浪健太郎, 梅澤玲, 高瀬圭, 高橋昭喜

日独医報　56　(2)　264-264　2011/12
Publisher: バイエル薬品(株)
ISSN： 0912-0351
2腔解離から3腔解離に進展した慢性大動脈解離の1例

大田英揮, 高瀬圭, 津田雅視, 熊谷紀一郎, 齋木佳克, 高橋昭喜

日独医報　56　(2)　270-270　2011/12
Publisher: バイエル薬品(株)
ISSN： 0912-0351
【副腎疾患の画像診断のポイント】クッシング症候群の画像診断

小野美澄, 高瀬圭, 森本玲, 高橋昭喜, 伊藤貞嘉, 佐藤文俊

ホルモンと臨床　59　(11)　983-989　2011/11
Publisher: (有)医学の世界社
ISSN： 0045-7167
原発性アルドステロン症の局在診断及び治療選択における副腎静脈サンプリングの意義と重要性<当科におけるCTとAVSの局在一致に関する最新の解析結果及び症例報告から>

岩倉芳倫, 森本玲, 工藤正孝, 小野美澄, 清治和将, 高瀬圭, 石戸谷滋人, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　34回　496-496　2011/10
Publisher: (NPO)日本高血圧学会
東日本大震災における宮城県内三次救急施設の放射線診断業務

湯澤寛尚, 高橋昭喜, 高瀬圭, 石井清, 山田隆之, 佐藤明弘, 袴塚崇

日本医学放射線学会秋季臨床大会抄録集　47回　S532-S532　2011/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
初診時CKDを合併したPA症例の臨床上特徴及び治療予後に関する検討

岩倉芳倫, 森本玲, 工藤正孝, 村上治, 小野美澄, 柳澤紀子, 清元秀泰, 高瀬圭, 清治和将, 高橋昭喜, 石戸谷滋人, 荒井陽一, 中村保宏, 鈴木貴, 笹野公伸, 伊藤貞嘉, 佐藤文俊

日本内分泌学会雑誌　87(Suppl.)　(Suppl.)　56-58　2011/06
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

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初診時慢性腎臓病(CKD)を合併した原発性アルドステロン症(PA)症例の臨床上特徴及び治療予後について検討した。既に推定糸球体濾過量(eGFR)が60ml/min/1.73m2未満のCKD-PA群、eGFR 60ml/min/1.73m2以上のnonCKD-PA群とし比較対象とした。CKD-PA群は、nonCKD-PA群に比べ、初診時のPRA及びPACが有意に高値であった。初診時のPRAはBaselineに比べ有意に上昇した。アルドステロン/レニン比(ARR)は初診時、Baseline及びカプトプリル投与後のいずれも20以上であった。しかし、30例中7例は初診時でARR20以上を満たさず、うち4例は鏡病理学的検討にてアルドステロン産生腺腫と診断した。また、4例はカプトプリル投与後ARR20以上を満たさなかった。Baselineでは30例全てARR20以上を満した。
左副腎偶発腫瘍を契機に診断へ至った原発性アルドステロン症の一例

森本玲, 佐藤文俊, 岩倉芳倫, 小野美澄, 工藤正孝, 村上治, 高瀬圭, 高橋昭喜, 石戸谷滋人, 荒井陽一, 中村保宏, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　87　(1)　249-249　2011/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
正常副腎温存両側副腎手術を施行し治癒した両側副腎アルドステロン産生腺腫の一例

岩倉芳倫, 森本玲, 工藤正孝, 村上治, 小野美澄, 清治和将, 高瀬圭, 石戸谷滋人, 荒井陽一, 中村保宏, 笹野公伸, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　87　(1)　355-355　2011/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
MDCT、MRIによる微細脈管構造描出・臨床応用および医療経済効果解析

高瀬圭, 李麗, 高橋昭喜

ナノ医工学年報　4　(1)　99-108　2011/03
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
3T MRIにおける頸動脈複雑プラーク(AHA type VI)と冠動脈病変との関連についての検討

大田英揮, 及川美奈子, 武田守彦, 安田聡, 高橋潤, 伊藤愛剛, 福本義弘, 高瀬圭, 下川宏明, 高橋昭喜

日独医報　55　(3-4)　315-315　2011/02
Publisher: バイエル薬品(株)
ISSN： 0912-0351
F-18 FDG・I-123 BMIPP・心臓MRIで放射線心筋障害が疑われた3症例

梅澤玲, 高瀬圭, 高浪健太郎, 神宮啓一, 有賀久哲, 金田朋洋, 大田英揮, 高橋昭喜, 山田章吾

日本医学放射線学会学術集会抄録集　70回　S209-S209　2011/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
NBCA-Lipiodol混合液による動脈塞栓効果の基礎的検討

高澤千晶, 清治和将, 松永賢一, 高瀬圭, 高橋昭喜, 松橋俊夫, 信太宗也, 太田信

日本医学放射線学会学術集会抄録集　70回　S316-S316　2011/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
ビーグル成犬の外腸骨動脈における動脈瘤モデル作成法の検討

松永賢一, 高澤千晶, 清治和将, 松橋俊夫, 高瀬圭, 高橋昭喜

日本医学放射線学会学術集会抄録集　70回　S318-S318　2011/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
胸部大動脈瘤術後患者に対するカンデサルタン投与による遠隔期の大動脈径変化の検討(パイロット・スタディより)

鈴木佑輔, 川本俊輔, 本吉直孝, 秋山正年, 熊谷紀一郎, 安達理, 齋藤武志, 増田信也, 渋谷拓見, 佐藤真一, 齋木佳克, 高瀬圭, 大田英揮, 辻一郎, 菅原由美

General Thoracic and Cardiovascular Surgery　59　(Supplement)　2011

ISSN： 1863-6705
喫煙関連肺疾患(DIPまたはRB)と診断された1例

荒井晃, 山田隆之, 津田雅視, 奥本忠之, 森菜緒子, 高瀬圭, 清治和将, 常陸真, 高橋昭喜

Japanese Journal of Radiology　29　(Suppl.I)　8-8　2011/01
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
当院での3T乳腺MRSの現状

山田隆之, 津田雅視, 奥本忠之, 高瀬圭, 森菜緒子, 清治和将, 常陸真, 高橋昭喜

Japanese Journal of Radiology　29　(Suppl.I)　8-8　2011/01
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
副腎ホルモン産生異常に関する調査研究 9.原発性アルドステロン症症例での副腎静脈サンプリング血中の18‐oxocortisol濃度測定の臨床的意義と課題

佐藤文俊, 中村保宏, 森本玲, 工藤正孝, 岩倉芳倫, 小野美澄, 村上治, 高瀬圭, 笹野公伸, 伊藤貞嘉

副腎ホルモン産生異常に関する調査研究平成22年度総括・分担研究報告書　145　2011
【副腎疾患最近の話題】原発性アルドステロン症診療の新たな流れ各科連携の成果

石戸谷滋人, 荒井陽一, 佐藤文俊, 伊藤貞嘉, 高瀬圭, 石橋忠司, 中村保宏, 笹野公伸

内分泌外科　27　(4)　235-240　2010/12
Publisher: (株)インターメルク
ISSN： 0914-9953
22歳で診断に至ったKallmann症候群の男性症例

工藤正孝, 村上治, 森本玲, 岩倉芳倫, 小野美澄, 高瀬圭, 高橋昭喜, 石戸谷滋人, 荒井陽一, 佐藤直子, 緒方勤, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　86　(3)　721-721　2010/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
初診時にCKDを合併したPAの臨床上特徴及び治療予後に関する検討

岩倉芳倫, 森本玲, 工藤正孝, 村上治, 小野美澄, 佐藤博, 高瀬圭, 高橋昭喜, 石戸谷滋人, 荒井陽一, 中村保宏, 笹野公伸, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　86　(3)　694-694　2010/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
原発性アルドステロン症における無症候性脳梗塞の発症と、eGFRおよびアルブミン尿との関連についての検討

工藤正孝, 佐藤文俊, 森本玲, 岩倉芳倫, 小野美澄, 高瀬圭, 日向野修一, 高橋昭喜, 村上治, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　33回　360-360　2010/10
Publisher: (NPO)日本高血圧学会
原発性アルドステロン症における尿中アルドステロンレベルの検討

森本玲, 佐藤文俊, 工藤正孝, 岩倉芳倫, 小野美澄, 高瀬圭, 石戸谷滋人, 中村保宏, 高橋昭喜, 荒井陽一, 笹野公伸, 村上治, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　33回　325-325　2010/10
Publisher: (NPO)日本高血圧学会
アルドステロン産生腺腫(APA)と特発性アルドステロン症は副腎静脈血18-oxocortisol(18-oxoF)で鑑別可能である

佐藤文俊, 中村保宏, 森本玲, 工藤正孝, 岩倉芳倫, 小野美澄, 村上治, 高瀬圭, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　86　(2)　402-402　2010/09
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
【IVRの最新デバイス(Part1)】副腎静脈サンプリング用カテーテル「アドセレクト」 (Rad Fan)

高瀬圭, 清治和将, 佐藤文俊, 森本玲

Rad Fan　8　(9)　66-67　2010/08
右副腎静脈の呼吸性上下変動の検討

北見昌広, 高瀬圭, 高橋昭喜

日本医学放射線学会秋季臨床大会抄録集　46回　S520-S520　2010/08
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
【肝門部の解剖を極める適切な手術とインターベンション治療のために】肝門部胆管解剖 CT-cholangiographyから

北見昌広, 高瀬圭, 高橋昭喜

胆と膵　31　(7)　711-715　2010/07
Publisher: 医学図書出版(株)
ISSN： 0388-9408
下肢AVMの治療経験

松永賢一, 高瀬圭, 清治和将, 松橋俊夫, 津田雅視, 山田隆之, 奥本忠之, 川住祐介, 高橋昭喜

Japanese Journal of Radiology　28　(Suppl.I)　6-6　2010/07
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
EOB・プリモビストを使用したMRIにおける3.0Tと1.5T MRIの比較

松永賢一, 津田雅視, 山田隆之, 奥本忠之, 清治和将, 松橋俊夫, 高瀬圭, 高橋昭喜

Japanese Journal of Radiology　28　(Suppl.I)　10-10　2010/07
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
Evaluation of right adrenal vein by MDCT-for accurate localization of aldosterone hypersecretion by selective adrenal venous sampling

Kei Takase, Fumitoshi Satoh, Ryo Morimoto, Kazumasa Seiji, Masashi Tsuda, Takayuki Yamada, Sadayoshi Ito, Shoki Takahashi

ENDOCRINE JOURNAL　57　S636-S636　2010/03

ISSN： 0918-8959
Endocrinological evaluation of successful sampling from right adrenal veins in patients with primary aldosteronism

Ryo Morimoto, Fumitoshi Satoh, Masataka Kudo, Osamu Murakami, Yoshitsugu Iwakura, Kei Takase, Tadashi Ishibashi, Shoki Takahashi, Shigeto Ishidoya, Yoichi Arai, Yasuhiro Nakamura, Takashi Suzuki, Hironobu Sasano, Sadayoshi Ito

ENDOCRINE JOURNAL　57　S627-S627　2010/03

ISSN： 0918-8959
Recommendation of adrenal venous sampling before surgical treatments for the patients of primary aldosteronism with adrenal nodules on CT: the differential diagnosis of 329 patients with primary aldosteronism in comparison with their computed tomographic findings

Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Yoshinori Iwakura, Osamu Murakami, Kei Takase, Shoki Takahashi, Yoichi Arai, Yoshihiro Nakamura, Takashi Suzuki, Hironobu Sasano, Sadayoshi Ito

ENDOCRINE JOURNAL　57　S552-S552　2010/03

ISSN： 0918-8959
Renal outcome in patients with primary aldosteronism: manifestation of "masked" CKD by correction of aldosterone-induced glomerular hyperfiltration and one-year follow-up with aldosterone blockade or unilateral adrenalectomy

Yoshitsugu Iwakura, Ryo Morimoto, Masataka Kudo, Osamu Murakami, Kei Takase, Shigeto Ishidoya, Yoichi Arai, Hironobu Sasano, Hiroshi Sato, Fumitoshi Satoh, Sadayoshi Ito

ENDOCRINE JOURNAL　57　S647-S647　2010/03

ISSN： 0918-8959
下垂体術後にアルドステロン分泌とアルブミン尿の低下を認めた先端巨大症の一例

宮澤恵実子, 森本玲, 松村美樹子, 工藤正孝, 村上治, 高瀬圭, 日向野修一, 高橋昭喜, 佐藤博, 池田秀敏, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　86　(1)　106-106　2010/03
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
GH/PRL/ACTHの染色を認めたTSH産生下垂体腺腫の一例

工藤正孝, 森本玲, 村上治, 中川芳則, 森弘毅, 高瀬圭, 日向野修一, 高橋昭喜, 池田秀敏, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　86　(1)　119-119　2010/03
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
プロラクチン産生下垂体腺腫を合併した原発性アルドステロン症の一例

尾股慧, 岩倉芳倫, 森本玲, 工藤正孝, 村上治, 高瀬圭, 石橋忠司, 日向野修一, 高橋昭喜, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　86　(1)　161-161　2010/03
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
マルチディテクターCT(MDCT)、MRIによる微細脈管構造描出とその臨床応用

高瀬圭, 李麗, 高橋昭喜

ナノ医工学年報　3　(1)　103-112　2010/03
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
Spironolactone body陽性の両側副腎アルドステロン産生微小腺腫による治療抵抗性高血圧症の一例

森本玲, 工藤正孝, 村上治, 岩倉芳倫, 宮沢恵実子, 高瀬圭, 石橋忠司, 高橋昭喜, 石戸谷滋人, 荒井陽一, 中村保宏, 鈴木貴, 笹野公伸, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　86　(1)　161-161　2010/03
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
Dual energy CTを用いた低電圧による乳癌病変の描出についての検討

森菜緒子, 山田隆之, 津田雅視, 奥本忠之, 高瀬圭, 清治和将, 高橋昭喜

日本医学放射線学会学術集会抄録集　69回　S258-S258　2010/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
【肝門部の解剖を極める適切な手術とインターベンション治療のために】肝門部胆管解剖 CT-cholangiographyから (胆と膵)

北見昌広, 高瀬圭, 高橋昭喜

胆と膵　31　(7)　711-715　2010
副腎ホルモン産生異常に関する調査研究(6)副腎癌の診断・治療法の検討 18F‐FDG PET/CTによる副腎腫瘍の鑑別診断

佐藤文俊, 森本玲, 工藤正孝, 村上治, 岩倉芳倫, 宮澤恵実子, 松田謙, 伊藤貞嘉, 高浪健太郎, 高瀬圭, 石橋忠司, 高橋昭喜, 伊藤明宏, 石戸谷滋人, 荒井陽一, 中村保宏, 鈴木貴, 笹野公伸

副腎ホルモン産生異常に関する調査研究平成21年度総括・分担研究報告書　107-112　2010
【副腎疾患最近の話題】原発性アルドステロン症診療の新たな流れ各科連携の成果 (内分泌外科(0914-9953))

石戸谷滋人, 荒井陽一, 佐藤文俊, 伊藤貞嘉, 高瀬圭, 石橋忠司, 中村保宏, 笹野公伸

内分泌外科(0914-9953)　27　(4)　235　2010
画像診断とIVRのための腹部血管解剖肝・胆・膵・脾肝臓(その2) 肝門部胆管と門脈の関係

北見昌広, 高瀬圭, 高橋昭喜

日独医報　54　(3-4)　369-372　2009/12
Publisher: バイエル薬品(株)
ISSN： 0912-0351
Radiological Anatomy of the Right Adrenal Vein: Preliminary Experience with Multi-detector Row Computed Tomography

Tomonori Matsuura, K. Takase, S. Takahashi

IFMBE Proceedings　23　2250-2253　2009/12/01

DOI： 10.1007/978-3-540-92841-6_564 　

ISSN： 1680-0737
64列MDCTによる左房容積測定 persistent Af、Paroxysmal Af、Sinus rhysmの比較

松本世津, 高瀬圭, 森田佳明, 一瀬あずさ, 高橋昭喜

日独医報　54　(3-4)　391-391　2009/12
Publisher: バイエル薬品(株)
ISSN： 0912-0351
MRIによる心筋炎の画像所見の検討

森田佳明, 齋藤春夫, 及川美奈子, 吉田さやか, 松本世津, 高瀬圭, 高橋昭喜

日独医報　54　(3-4)　393-393　2009/12
Publisher: バイエル薬品(株)
ISSN： 0912-0351
cine MRIによるLeft ventricular dyssynchronyの評価

一瀬あずさ, 高瀬圭, 松本世津, 吉田さやか, 若山裕司, 下川宏明, 高橋昭喜

日独医報　54　(3-4)　400-400　2009/12
Publisher: バイエル薬品(株)
ISSN： 0912-0351
Evaluating Spinal Vessels and the Artery of Adamkiewicz Using 3-Dimensional Imaging

Kei Takase, Sayaka Yoshida, Shoki Takahashi

IFMBE Proceedings　23　2215-2218　2009/12/01

DOI： 10.1007/978-3-540-92841-6_555 　

ISSN： 1680-0737
進行性臓器障害を伴った原発性アルドステロン症の治療をどう考えるか?【長期スピロノラクトン療法中に臓器障害が進展した重症原発性アルドステロン症の一例の検討】

岩倉芳倫, 佐藤文俊, 森本玲, 工藤正孝, 松田謙, 村上治, 高瀬圭, 山田隆之, 高橋昭喜, 伊藤昭宏, 石戸谷滋人, 荒井陽一, 鈴木貴, 笹野公伸, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　32回　316-316　2009/10
Publisher: (NPO)日本高血圧学会
重症高血圧症を呈するACTH非依存性クッシング症候群におけるアルドステロンの関与 ACTH負荷副腎静脈サンプリングにより明らかにされた病態

森本玲, 佐藤文俊, 工藤正孝, 岩倉芳倫, 宮澤恵美子, 松田謙, 村上治, 高瀬圭, 高橋昭喜, 伊藤明宏, 石戸谷滋人, 荒井陽一, 鈴木貴, 笹野公伸, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　32回　316-316　2009/10
Publisher: (NPO)日本高血圧学会
ECG-gated MDCT of the patent ductus arteriosus in adult cases. Imaging findings and impact on management

K. Takase, S. Matsumoto, S. Yoshida, Y. Morita, H. Saito, S. Takahashi

EUROPEAN HEART JOURNAL　30　490-490　2009/09

ISSN： 0195-668X
肺塞栓症に伴うparadoxical embolism疑い症例

北見昌広, 高瀬圭, 山田隆之, 高橋昭喜

日本医学放射線学会秋季臨床大会抄録集　45回　S531-S531　2009/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
急性心不全を契機に診断したコルチゾル・テストステロン産生副腎皮質腺腫の一例

宮澤恵実子, 森本玲, 工藤正孝, 村上治, 高瀬圭, 石戸谷滋人, 中村保宏, 高橋昭喜, 荒井陽一, 鈴木貴, 笹野公伸, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　85　(Suppl.)　120-122　2009/08/20
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

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55歳女。呼吸困難、下腿浮腫、歩行困難を主訴とした。前医にて心不全、高血圧緊急症の診断で加療され、腹部CTにて長径55mmの右副腎腫瘍を指摘された。一般検査、内分泌検査、副腎造影CT・MRI、FDG/PET-CT、アドステロールシンチグラフィー各所見より、コルチゾル産生右副腎腫瘍によるクッシング症候群と診断し、鏡下右副腎摘出術を行った。心不全は高コルチゾル血症による心筋障害や重症高血圧症の複合による発症で、内分泌検査結果より右副腎腫瘍由来のアンドロゲン産生を疑った。摘出腫瘍は病理所見より副腎皮質腺腫と診断し、ステロイド合成酵素に対する免疫組織化学法では、本腫瘍によるコルチゾル、DHEA-S、テストステロン産生を示した。術後、血中テストステロンレベル低下、ゴナドトロピン分泌回復を認め、高血圧症は寛解した。術後4ヵ月現在、トリアムシノロンによる補充療法中である。
両側副腎にアルドステロン産生微小腺腫を伴ったクッシング症候群の一例

高橋(山田, 友里恵, 森本玲, 工藤正孝, 村上治, 高瀬圭, 石戸谷滋人, 中村保宏, 石橋忠司, 高橋昭喜, 荒井陽一, 鈴木貴, 笹野公伸, 佐藤文俊, 伊藤貞嘉

日本内分泌学会雑誌　85　(Suppl.)　123-125　2009/08/20
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

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64歳女。満月様顔貌、中心性肥満、野牛様肩、下腿浮腫を主訴とした。多系統萎縮症、高血圧症、2型糖尿病の既往がある。胸部単純X線、心臓超音波、一般血液検査、副腎造影CT、副腎アドステロールシンチ各検査所見より、コルチゾール産生右副腎腫瘍によるクッシング症候群と診断した。また、内分泌検査、ACTH負荷副腎静脈サンプリング検査の結果、右副腎由来のコルチゾール過剰分泌、両側副腎由来のアルドステロン過剰分泌と診断した。高コルチゾール血症に対してmetyraponeを投与し、鏡視下で一期的に右副腎部分切除・左副腎全摘術を行った。術後、臓器障害の進行は止まり、高血圧症は寛解した。病理所見にてコルチゾール産生右副腎腺腫によるDHEA-S産生を認め、右付随副腎及び左副腎にアルドステロン産生微小腺腫を認めたことより、両側副腎のアルドステロン産生微小腺腫による原発性アルドステロン症を伴ったクッシング症候群と診断した。
BILATERAL ALDOSTERONE PRODUCING ADENOMA - ROLE OF ADRENAL VENOUS SAMPLING AND BILATERAL SUBTOTAL ADRENALECTOMY

F. Satoh, R. Morimoto, M. Kudo, O. Murakami, K. Takase, T. Ishibashi, Y. Arai, H. Sasano, S. Ito

JOURNAL OF HYPERTENSION　27　S342-S342　2009/06

ISSN： 0263-6352
Image Analysis Software Next Advances 次世代の画像解析ソフトウェア肝臓解析ソフトによる術前門脈塞栓術前後の肝容積測定経静脈性造影CTによる解析

奥本忠之, 山田隆之, 津田雅視, 清治和将, 松橋俊夫, 高瀬圭, 高橋昭喜

INNERVISION　24　(6付録)　18-19　2009/05
Publisher: (株)インナービジョン
ISSN： 0913-8919
外傷性下横隔動脈損傷に対しTAEを施行し救命しえた一例

湯澤寛尚, 松橋俊夫, 津田雅視, 清治和将, 高瀬圭, 奥本忠之, 山田隆之, 高橋昭喜, 小林道生, 工藤大介, 山内聡, 篠澤洋太郎

Radiat Med　27　(Supplement 1)　2　2009/04/25

ISSN： 0288-2043
肺結節検出用CADシステムの診断性能比較放射線科医vs.Lung VCAR vs.Lung CARE

川住祐介, 山田隆之, 高瀬圭, 松橋俊夫, 津田雅視, 清治和将, 奥本忠之, 金田朋洋, 高橋昭喜

Japanese Journal of Radiology　27　(Suppl.)　1-1　2009/04
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
外傷性下横隔動脈損傷に対しTAEを施行し救命しえた一例

湯澤寛尚, 松橋俊夫, 津田雅視, 清治和将, 高瀬圭, 奥本忠之, 山田隆之, 高橋昭喜, 小林道生, 工藤大介, 山内聡, 篠澤洋太郎

Japanese Journal of Radiology　27　(Suppl.)　2-2　2009/04
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
Dual-energy CT(DECT)によるLung perfusionの初期経験

森田佳明, 山田隆之, 高瀬圭, 松橋俊夫, 津田雅視, 清治和将, 奥本忠之, 高橋昭喜

Japanese Journal of Radiology　27　(Suppl.)　8-8　2009/04
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
Dual source CTとMRIを用いたLeft ventricular dyssynchronyの評価

一瀬あずさ, 高瀬圭, 森田佳明, 松本世津, 高橋昭喜, 若山裕司, 下川宏明

Japanese Journal of Radiology　27　(Suppl.)　8-8　2009/04
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
多孔性covered SENDAI stent ビーグル犬の腸骨動脈を利用した生物学的検討

佐藤幸子, 松橋俊夫, 清治和将, 高瀬圭, 山田隆之, 日向野修一, 高橋昭喜, 石橋忠司, 植田初江, 周粤びん, 中山泰秀, 岡本吉弘

Japanese Journal of Radiology　27　(Suppl.)　10-10　2009/04
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
AVR術前に冠動脈・気管支動脈肺動脈瘻塞栓を施行した1例

松永賢一, 高瀬圭, 森田佳明, 山田隆之, 松橋俊夫, 津田雅視, 清治和将, 奥本忠之, 高橋昭喜, 齋藤春夫

Japanese Journal of Radiology　27　(Suppl.)　14-14　2009/04
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
マルチディテクターCT(MDCT)による細血管構造描出の臨床応用

高瀬圭, 李麗, 高橋昭喜

ナノ医工学年報　2　(1)　99-107　2009/03
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
MDCTによるCardiac Resynchronization Therapy(CRT)前の冠静脈評価

松本世津, 高瀬圭, 森田佳明, 一瀬あずさ, 高橋昭喜, 若山祐司

日独医報　54　(1)　72-72　2009/02
Publisher: バイエル薬品(株)
ISSN： 0912-0351
原発性アルドステロン症診療の最前線と放射線科医の役割高頻度存在する原発性アルドステロン症での放射線医の果たす決定的役割

佐藤文俊, 森本玲, 工藤正孝, 村上治, 高瀬圭, 石橋忠司, 高橋昭喜, 石戸谷滋人, 荒井陽一, 笹野公伸, 伊藤貞嘉

日本医学放射線学会学術集会抄録集　68回　S76-S76　2009/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
Image Analysis Software Next Advances 次世代の画像解析ソフトウェア肝臓解析ソフトによる術前門脈塞栓術前後の肝容積測定経静脈性造影CTによる解析 (INNERVISION)

奥本忠之, 山田隆之, 津田雅視, 清治和将, 松橋俊夫, 高瀬圭, 高橋昭喜

INNERVISION　24　(6付録)　18-19　2009
【造影CTにおける至適造影剤投与方法を探る】 Dual Source CTにおける心臓CTの実際 (映像情報Medical)

一瀬あずさ, 高瀬圭, 森田佳明, 高橋昭喜

映像情報Medical　41　(8)　728-731　2009
画像診断とIVRのための腹部血管解剖肝・胆・膵・脾肝臓(その2) 肝門部胆管と門脈の関係 (日独医報)

北見昌広, 高瀬圭, 高橋昭喜

日独医報　54　(3月4日)　369-372　2009
肺塞栓症を合併した肺動脈原発血管肉腫の1剖検例

清水亨, 杉村宏一郎, 福本義弘, 及川美奈子, 佐藤公雄, 中野誠, 下川宏明, 高瀬圭, 伊藤しげみ, 中村保宏

日本循環器学会東北地方会(Web)　149th　TOHOKU149,5 (WEB ONLY)　2009
【副腎腫瘍Update】原発性アルドステロン症副腎静脈サンプリングの手技と有用性 (Urology View)

石橋忠司, 高瀬圭, 山田隆之, 松橋俊夫, 津田雅視, 佐藤文俊, 伊藤貞嘉, 石戸谷滋人, 荒井陽一

Urology View　6　(6)　75-79　2008/12
次世代の画像解析ソフトウェア肝臓解析ソフトによる術前門脈塞栓術前後の肝容積測定経静脈性造影CTによる解析

奥本忠之, 山田隆之, 津田雅視, 清治和将, 松橋俊夫, 高瀬圭, 高橋昭喜

INNERVISION　23　(12)　82-83　2008/11
Publisher: (株)インナービジョン
ISSN： 0913-8919
Evaluation of cardiac dyssynchrony in patients with chronic heart failure using cardiacmagnetic resonance imaging

Yuji Wakayama, Koji Fukida, Masanori Hirose, Nobuhiro Yamaguchi, Minako Oikawa, Azusa Ichinose, Kei Takase, Yutaka Kagaya, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　14　(7)　S164-S164　2008/09

ISSN： 1071-9164
CT findings of "reduction en masse" of an inguinal hernia

Masahiro Kitami, Takayuki Yamada, Tadashi Ishii, Masahiro Tsuboi, Takashi Hakamatsuka, Kei Takase, Shoki Takahashi

European Journal of Radiology Extra　67　2008/09/01

DOI： 10.1016/j.ejrex.2008.05.014 　

ISSN： 1571-4675
副腎静脈サンプリング意義、解剖、手技

高瀬圭, 森本玲, 佐藤文俊

画像診断　28　(9)　972-984　2008/07
MDCTによる左房容積測定の検討

松本世津, 高瀬圭, 森田佳明, 一瀬あずさ, 高橋昭喜

日独医報　53　(1)　160-160　2008/06
Publisher: バイエル薬品(株)
ISSN： 0912-0351
AVR術前に冠動脈・気管支動脈-肺動脈瘻塞栓を施行した一例

松永賢一, 高瀬圭, 森田佳明, 山田隆之, 松橋俊夫, 津田雅視, 清治和将, 奥本忠之, 高橋昭喜, 齋藤春夫

核医学　45　(2)　142-142　2008/05
Publisher: (一社)日本核医学会
ISSN： 0022-7854
16列MDCTによる食道癌リンパ節転移の評価

森田佳明, 高瀬圭, 山田隆之, 佐藤明弘, 松橋俊夫, 金田朋洋, 日向野修一, 高橋昭喜, 市川宏文

Radiation Medicine　26　(Suppl.I)　2-2　2008/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
心電図同期CTを用いた動脈管開存症の診断

森田佳明, 高瀬圭, 高橋昭喜, 斎藤春夫

Radiation Medicine　26　(Suppl.I)　7-7　2008/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
dual energy CTによる副腎結節病変の単純CT値の検討

山田隆之, 高瀬圭, 松橋俊夫, 津田雅視, 清治和将, 奥本忠之, 金田朋洋, 高橋昭喜

日本医学放射線学会学術集会抄録集　67回　S214-S214　2008/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
ヘルニア偽還納のCT所見

北見昌広, 石井正, 大原勝人, 壷井匡浩, 高瀬圭, 山田隆之, 高橋昭喜

日本医学放射線学会学術集会抄録集　67回　S332-S332　2008/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
急性上腸間膜動脈閉塞に対する血栓吸引除去カテーテル使用の初期経験

津田雅視, 山田隆之, 奥本忠之, 清治和将, 松橋俊夫, 高瀬圭, 力丸裕哉, 栗原紀子, 佐藤明弘, 高橋昭喜

日本医学放射線学会学術集会抄録集　67回　S362-S362　2008/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
Analysis of vascular structure using dual MDCT: Evaluation of 3 and 4 dimensional morphology of vascular structure and analysis of organic blood perfusion. (Annals of nanoBME)

Shoki Takahashi, Kei Takase, Yoshiaki Morita, Tomonori Matsuura

Annals of nanoBME　1　93-102　2008
次世代の画像解析ソフトウェア肝臓解析ソフトによる術前門脈塞栓術前後の肝容積測定経静脈性造影CTによる解析 (INNERVISION)

奥本忠之, 山田隆之, 津田雅視, 清治和将, 松橋俊夫, 高瀬圭, 高橋昭喜

INNERVISION　23　(12)　82-83　2008
【Cardiac Imaging 2008】心臓CTの検査法の実際 (臨床画像)

森田佳明, 壷井匡浩, 高瀬圭, 高橋昭喜

臨床画像　24　(11月増刊)　17-25　2008
【MRIでなにがどこまでわかるか 2008年の現状】肝 (臨床画像)

津田雅視, 山田隆之, 奥本忠之, 清治和将, 松橋俊夫, 高瀬圭, 高橋昭喜

臨床画像　24　(12)　1440-1446　2008
AVSによるコルチゾル・アルドステロン同時過剰分泌の局在診断

森本玲, 佐藤文俊, 村上治, 高瀬圭, 山田隆之, 石戸谷滋人, 齋藤誠一, 鈴木貴, 石橋忠司, 高橋昭喜, 荒井陽一, 笹野公伸, 伊藤貞嘉

日本内分泌学会雑誌　83　(3)　733-733　2007/12
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661
CTにおけるヨード造影剤投与法のトレンド大血管と分枝・骨盤・下肢

大田英揮, 高瀬圭

臨床画像　23　(10)　1224-1226　2007/10/26

ISSN： 0911-1069
2管球CTによる心臓CTの初期経験

森田佳明, 高瀬圭, 松本世津, 一瀬あずさ, 高橋昭喜

日独医報　52　(3)　431-431　2007/09
Publisher: バイエル薬品(株)
ISSN： 0912-0351
MDCTを用いた心房細動アブレーション治療後における左房リモデリングの検討

一瀬あずさ, 高瀬圭, 熊谷浩司, 森田佳明, 松本世津, 下川宏明, 高橋昭喜

日独医報　52　(3)　435-435　2007/09
Publisher: バイエル薬品(株)
ISSN： 0912-0351
【モダリティの高機能化と3D画像】 CTによる3D画像の可能性臨床の場で不可欠な存在となった3D画像 (新医療)

森田佳明, 高瀬圭, 山田隆之, 松本世津, 大下亮介, 町井祐輔, 大田英揮, 壺井匡浩

新医療　34　(8)　116-119　2007/08
血管エコー検査の標準化をめざして透析シャント診断とインターベンションのための血管エコー

高瀬圭, 力丸裕哉, 阿部香代子, 高橋昭喜

超音波医学　34　(Suppl.)　S227-S227　2007/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
MRIを用いた心サルコイドーシスにおける心筋障害の検討

一瀬あずさ, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 斎藤春夫, 大谷宏紀, 加賀谷豊

Radiation Medicine　25　(Suppl.I)　3-3　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
門脈分岐異常の有無時の胆管合流形態の検討

北見昌広, 高瀬圭, 齋藤春夫, 壺井匡宏, 高橋昭喜, 村上弦, 高済峯, 中島祥介

Radiation Medicine　25　(Suppl.I)　4-4　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
Papillary RCCの画像診断

壷井匡浩, 清治和将, 遠藤希之, 高瀬圭, 石橋忠司, 高橋昭喜, 齋藤春夫

Radiation Medicine　25　(Suppl.I)　4-4　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
尿膜管膿瘍の画像的検討

森田佳明, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜

Radiation Medicine　25　(Suppl.I)　4-4　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
兎正常肺に対するラジオ波焼灼後のCT所見と病理組織像との対比特に「治療効果範囲」について

冨永循哉, 宮地秀夫, 石橋忠司, 佐藤明弘, 山田隆之, 高瀬圭, 高橋昭喜

Radiation Medicine　25　(Suppl.I)　5-5　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
MDCT cholangiographyを用いた門脈分岐変異と胆管形態の関連性の検討右葉移植に関連して

北見昌広, 高瀬圭, 齋藤春夫, 壺井匡宏, 日向野修一, 高橋昭喜, 高済峯, 中島祥介

Radiation Medicine　25　(Suppl.I)　11-11　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
民生用液晶モニタは診断モニタとして十分か? AAPM TG18テストパターンを用いた検証

川住祐介, 壷井匡浩, 石橋忠司, 高瀬圭, 山田隆之, 佐藤明弘, 高橋昭喜

Radiation Medicine　25　(Suppl.I)　13-13　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
遅延造影MRIを用いた拡張型心筋症における心筋障害の検討

一瀬あずさ, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 齋藤春夫, 大谷宏紀, 及川美奈子, 加賀谷豊

Radiation Medicine　25　(Suppl.I)　14-14　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
原発性肺高血圧症に合併した肺動脈仮性瘤の1例

峰村出, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 相馬真子

Radiation Medicine　25　(Suppl.I)　21-21　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
Bronchial atresiaのCT診断

佐藤幸子, 山田隆之, 高瀬圭, 佐藤明弘, 金田朋洋, 常陸真, 石橋忠司, 高橋昭喜

Radiation Medicine　25　(Suppl.I)　23-23　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
MDCTにおける右副腎静脈描出についての検討

松浦智徳, 高瀬圭, 松橋俊夫, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜

Radiation Medicine　25　(Suppl.I)　26-26　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
MDCTによる胸腔鏡下食道癌手術の3D simulation

森田佳明, 高瀬圭, 松橋俊夫, 山田隆之, 佐藤明弘, 高橋昭喜, 市川宏文

Radiation Medicine　25　(Suppl.I)　27-27　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
【心不全最新の基礎・臨床研究の進歩】診断学・検査の進歩 CT,MRI検査 (日本臨床)

一瀬あずさ, 高瀬圭, 加賀谷豊, 下川宏明, 高橋昭喜

日本臨床　65　(増刊4 心不全(上))　406-411　2007/04/01
PE-319 Usefulness of Three-Dimensional Analysis with Multi-Detector Row Computed Tomography in the Treatment of Atrial Fibrillation(CT/DSA-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Ichinose Azusa, Kumagai Koji, Takase Kei, Morita Yoshiaki, Kagaya Yutaka, Takahashi Shoki, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　71　404-404　2007/03/01
Publisher: Japanese Circulation Society
ISSN： 1346-9843
IVRにおける患者および術者の被曝低減法

千田浩一, 齋藤春夫, 洞口正之, 高瀬圭, 梁川功, 加賀谷豊, 石橋忠司, 高井良尋, 高橋昭喜, 山田章吾

日本医学放射線学会学術集会抄録集　66回　S96-S96　2007/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
心電図同期CTによる先天性心疾患IVRの術前simulation

森田佳明, 高瀬圭, 松橋俊夫, 山田隆之, 佐藤明弘, 日向野修一, 高橋昭喜

日本医学放射線学会学術集会抄録集　66回　S166-S166　2007/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
乳頭状腎細胞癌の病理学的サブタイプとCT画像との比較

山田隆之, 佐藤明弘, 松橋俊夫, 高瀬圭, 奥本忠之, 常陸真, 金田朋洋, 高橋昭喜, 遠藤希之

日本医学放射線学会学術集会抄録集　66回　S199-S200　2007/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
MDCTによる大腿ヘルニア、鼠径ヘルニアの鑑別鼠径靱帯に着目して

北見昌広, 高瀬圭, 間島一浩, 壺井匡浩, 力丸裕哉, 大田英揮, 山田隆之, 佐藤明弘, 高橋昭喜

日本医学放射線学会学術集会抄録集　66回　S339-S339　2007/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
下肢静脈疾患と超音波検査の進め方―いかに深部静脈血栓症・下肢静脈瘤をエコーで診るか―1 種々の画像診断の特徴を知る Invited

大田英揮, 高瀬圭, 星俊子

Med Technol　113-122　2007/01

ISSN： 0389-1887
【膵・胆道周囲の腫瘤性病変後腹膜を中心に】膵・胆道周囲の腫瘤性病変の画像血管造影 (消化器画像)

石橋忠司, 佐藤明弘, 山田隆之, 松橋俊夫, 高瀬圭

消化器画像　8　(6)　687-691　2006/11

DOI： 10.11477/mf.1427100219 　
【Interventional Radiologyのコツ】胆道・膵・脾急性膵炎動注療法

佐藤明弘, 石橋忠司, 山田隆之, 高瀬圭, 松橋俊夫, 清治和将, 常陸真, 奥本忠之, 金田朋洋, 日向野修, 武田和憲, 高橋昭喜

臨床放射線　51　(11)　1525-1528　2006/10
Publisher: 金原出版(株)
ISSN： 0009-9252
16列MDCTによる食道癌リンパ節転移の評価

森田佳明, 高瀬圭, 山田隆之, 佐藤明弘, 日向野修一, 高橋昭喜, 市川宏文

断層映像研究会雑誌　33　(2)　74-75　2006/08
Publisher: 断層映像研究会
ISSN： 0914-8663
肝左葉における胆管合流形態と走行形態の関連性:MDCT cholangiography 500例での検討

北見昌広, 高瀬圭, 壷井匡浩, 齋藤春夫, 間島一浩, 山田隆之, 日向野修一, 高橋昭喜

日本医学放射線学会学術集会抄録集　65回　S138-S138　2006/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
MDCTによる右副腎静脈の描出能,解剖学的形態の検討

松浦智徳, 高瀬圭, 松橋俊夫, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜

日本医学放射線学会学術集会抄録集　65回　S188-S188　2006/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
MDCTによる胸腔鏡下食道癌手術の3D simulation

森田佳明, 高瀬圭, 松橋俊夫, 山田隆之, 佐藤明弘, 高橋昭喜, 市川宏文

日本医学放射線学会学術集会抄録集　65回　S297-S297　2006/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
医療用高精細液晶モニタと民生用液晶モニタでの診断能の違い肝臓単純CTによる検証

川住祐介, 山田隆之, 大田英揮, 壺井匡浩, 高瀬圭, 佐藤明弘, 石橋忠司, 高橋昭喜

日本医学放射線学会学術集会抄録集　65回　S302-S302　2006/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
兎正常肺に対するラジオ波焼灼後のCT所見と病理組織像の経時的変化

冨永循哉, 宮地秀夫, 高瀬圭, 松橋俊夫, 山田隆之, 佐藤明弘, 斎藤春夫, 石橋忠司, 日向野修一, 高橋昭喜

日本医学放射線学会学術集会抄録集　65回　S336-S336　2006/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
Covered stentが有効であった膵頭十二指腸切除術後出血の1例

佐藤幸子, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜

IVR: Interventional Radiology　21　(1)　86-86　2006/01
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
RFAが奏効したosteoid osteomaの2例

目時隆博, 高瀬圭, 北見昌広, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜

IVR: Interventional Radiology　21　(1)　87-87　2006/01
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
【肝区域の新しい見方】画像から見た肝区域 CT cholangiography(DIC-CT) (消化器画像)

北見昌広, 高瀬圭, 村上弦, 壷井匡宏, 齋藤春夫, 間島一浩, 佐藤明弘, 山田隆之, 日向野修一, 高橋昭喜

消化器画像　8　(3)　305-312　2006

DOI： 10.11477/mf.1427100157 　
【血管炎その臨床所見と画像診断】大動脈疾患

大田英揮, 高瀬圭, 高橋昭喜

臨床画像　21　(8)　840-848　2005/08
Publisher: (株)メジカルビュー社
ISSN： 0911-1069
腎原発Primitive Neuroectodermal Tumorの1例

壺井匡浩, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 遠藤希之

日独医報　50　(2)　386-387　2005/06
Publisher: バイエル薬品(株)
ISSN： 0912-0351
遅延造影MRIを用いた拡張型心筋症における心筋障害の検討

一瀬あずさ, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 齋藤春夫, 大谷宏紀, 及川美奈子, 加賀谷豊

日独医報　50　(2)　414-414　2005/06
Publisher: バイエル薬品(株)
ISSN： 0912-0351
【3D PACS ネットワーク対応リアルタイム3Dイメージング】 3D PACS運用の実際大規模〜小規模システムの構築例(海外事例も含めて) 読影スタイルと画像データ配信の現状 (INNERVISION)

川住祐介, 高瀬圭, 石橋忠司, 壺井匡浩

INNERVISION　20　(5)　112-114　2005/04
Radiographic and CT findings of the paraquat lung

Azusa Ichinose, K. Takase, M. Tsuboi, T. Yamada, A. Sato, T. Ishibashi, S. Takahashi, K. Kimura, M. Hayashi

Japanese Journal of Clinical Radiology　50　27-32　2005/02/21

ISSN： 0009-9252
Fogarty法およびバルーン血管形成・ステント留置を併用して治療し得た広範囲腸骨大腿動脈閉塞の1例

力丸裕哉, 後藤均, 初貝和明, 石井正, 金田巌, 高瀬圭

日独医報　49　(4)　747-747　2005/02
Publisher: バイエル薬品(株)
ISSN： 0912-0351
心血管インターベンションにおける患者皮膚最大線量と,透視時間,面積線量,患者BMIの関係

千田浩一, 齋藤春夫, 洞口正之, 大谷宏紀, 志村浩孝, 高瀬圭, 佐々木正寿, 高橋昭喜, 山田章吾, 白土邦男

日本医学放射線学会学術集会抄録集　64回　S103-S103　2005/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
胸腹部大動脈CT-Angiographyにおける造影濃度均一性の評価

力丸裕哉, 千葉美洋, 高瀬圭, 石橋忠司, 高橋昭喜

日本医学放射線学会学術集会抄録集　64回　S173-S173　2005/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
遅延造影MRIを用いた拡張型心筋症における心筋障害の検討

一瀬あずさ, 大谷宏紀, 及川美奈子, 高瀬圭, 山田隆之, 佐藤明弘, 加賀谷豊, 斎藤春夫, 石橋忠司, 高橋昭喜

日本医学放射線学会学術集会抄録集　64回　S221-S221　2005/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
MDCT cholangiographyを用いた門脈分岐変異と胆管形態の関連性の検討

北見昌広, 村上弦, 高済峯, 高瀬圭, 壷井匡宏, 齋藤春夫, 日向野修一, 中島祥介, 高橋昭喜

日本医学放射線学会学術集会抄録集　64回　S272-S272　2005/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
参照・教育用イメージマネージメントシステムによる画像データベースの構築・運用

川住祐介, 石橋忠司, 山田隆之, 佐藤明弘, 高瀬圭, 高橋昭喜

日本医学放射線学会学術集会抄録集　64回　S401-S401　2005/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
グラフトシャントIVR中に動脈側遠位塞栓をきたした1例

大田英揮, 高瀬圭, 高橋昭喜

日独医報　49　(4)　747-747　2005/02
Publisher: バイエル薬品(株)
ISSN： 0912-0351
MRIを用いた心サルコイドーシスにおける心筋障害の検討

一瀬あずさ, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 齋藤春夫, 大谷宏紀, 及川美奈子, 加賀谷豊

日独医報　49　(4)　751-751　2005/02
Publisher: バイエル薬品(株)
ISSN： 0912-0351
肺癌定位照射用金マーカー留置に伴う合併症の検討

松浦智徳, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 根本健二, 高井良尋, 壷井匡浩

IVR: Interventional Radiology　20　(2)　221-221　2005/02
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
膵頭十二指腸切除後に術後出血を繰り返し,治療に難渋した1例

三浦由啓, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜

IVR: Interventional Radiology　20　(2)　223-223　2005/02
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
腎動脈完全閉塞をPTRAで治療しえたFMDの1例

嶋内亜希子, 高瀬圭, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜

IVR: Interventional Radiology　20　(2)　223-224　2005/02
Publisher: (一社)日本インターベンショナルラジオロジー学会
ISSN： 1340-4520
MDCTによる虫垂炎の画像診断

壺井匡浩, 高瀬圭, 高橋昭喜

画像診断　25　(2)　214-223　2005/01
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524
後腹膜鏡視下腎部分切除術におけるvirtual laparoscopic 3Dイメージの有用性 (Japanese Journal of Endourology and ESWL)

加藤正典, 伊藤明宏, 佐藤信, 荒井陽一, 新宅一郎, 高瀬圭, 加藤裕美子

Japanese Journal of Endourology and ESWL　18　(3)　218-218　2005
パラコート中毒の胸部画像

一瀬あずさ, 高瀬圭, 壺井匡浩, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 木村啓二, 林雅人, 斎藤昌宏, 高橋さつき

臨床放射線　50　(1)　27-32　2005/01
Publisher: 金原出版(株)
ISSN： 0009-9252
MDCTによる虫垂炎の画像診断 (画像診断)

壺井匡浩, 高瀬圭, 高橋昭喜

画像診断　25　(2)　214-223　2005
【血管炎その臨床所見と画像診断】大動脈疾患 (臨床画像)

大田英揮, 高瀬圭, 高橋昭喜

臨床画像　21　(8)　840-848　2005
Simultaneous Evaluation of Whole Aorta and the Artery of Adamkiewicz by MDCT

TAKASE Kei

44　(11)　693-699　2004/11/25

ISSN： 0387-1126
MDCTとMRIによる乳癌の局所進展診断

嶋内亜希子, 高瀬圭, 壺井匡浩, 松橋俊夫, 佐藤明弘, 齋藤春夫, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(8)　579-579　2004/11
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
経静脈造影MDCTにおける正常虫垂の性状・同定率の検討

壺井匡浩, 高瀬圭, 大田英揮, 川住祐介, 力丸裕哉, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(8)　581-581　2004/11
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
血管腫様の形状を示した門脈-肝静脈短絡の1例

松浦智徳, 松橋俊夫, 高瀬圭, 佐藤明弘, 齋藤春夫, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(8)　583-583　2004/11
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
重症心サルコイドーシスの1例

目時隆博, 壺井匡浩, 松橋俊夫, 高瀬圭, 佐藤明弘, 齋藤春夫, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(8)　584-584　2004/11
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
A clinical pass for the diagnosis of primary aldosteronism localization by adrenal venous sampling with ACTH stimulation(Significance of ACTH-loaded adrenal venous sampling in adrenal primary aldosteronism,Proceedings of the 2nd Conference on Adrenal Veno

SATOH Fumitoshi, ABE Takaaki, TANEMOTO Masayuki, NAKAMURA Masahiro, ABE Michiaki, SUZUKI Saya, MORIMOTO Ryo, CHIAKI Tatsuji, SATO Akihiro, TAKASE Kei, ISHIDOYA Shigeto, SUZUKI Takashi, ARAI Yoichi, SASANO Hironobu, ISHIBASHI Tadashi, ITO Sadayoshi

Journal of Tokyo Women's Medical College　74　(9)　598-598　2004/10
Publisher: Tokyo Women's Medical University
ISSN： 0040-9022
急性肺塞栓症の画像診断,その利点と限界ヘリカルCT

齋藤春夫, 石橋忠司, 佐藤明弘, 山田隆之, 高瀬圭, 松橋俊夫, 壺井匡浩, 高橋昭喜

Therapeutic Research　25　(6)　1283-1284　2004/06
Publisher: ライフサイエンス出版(株)
ISSN： 0289-8020
CTAPで肝S2,3に非定型的pseudolesionsを生じた1例

川住祐介, 佐藤明弘, 松橋俊夫, 高瀬圭, 斉藤春夫, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(4)　258-259　2004/05
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
急性膵炎を繰り返したALL膵浸潤の1例

湯沢寛尚, 松橋俊夫, 高瀬圭, 佐藤明弘, 斉藤春夫, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(4)　259-259　2004/05
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
MDCTによる消化管穿孔の評価

高瀬圭, 大田英揮, 斉藤春夫, 佐藤明弘, 松橋俊夫, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(4)　259-260　2004/05
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
膜様構造物を伴った動脈管開存症(PDA)の1例心電同期3D-CTの有用性

大田英揮, 高瀬圭, 松橋俊夫, 佐藤明弘, 斉藤春夫, 石橋忠司, 高橋昭喜, 高山真, 祐川博康

日本医学放射線学会雑誌　64　(4)　261-261　2004/05
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
MDCTによる下肢動脈閉塞性疾患の評価血管走行に垂直な連続断面を用いて

大田英揮, 高瀬圭, 千葉美洋, 五十嵐和正, 齋藤春夫, 高橋昭喜

日独医報　49　(1)　171-171　2004/04
Publisher: バイエル薬品(株)
ISSN： 0912-0351
高度屈曲可能な新しい血管内ステント"SENDAI stent"の開発

半田和義, 松橋俊夫, 宮地秀雄, 佐藤明弘, 齋藤春夫, 高瀬圭, 石橋忠司, 高橋昭喜

日独医報　49　(1)　172-172　2004/04
Publisher: バイエル薬品(株)
ISSN： 0912-0351
CO2をコントラストに用いて施行したPTRAの2例

高瀬圭, 石橋忠司, 齋藤春夫, 佐藤明弘, 松橋俊夫, 高橋昭喜, 阿部高明, 伊藤貞嘉

日独医報　49　(1)　172-172　2004/04
Publisher: バイエル薬品(株)
ISSN： 0912-0351
【MDCT利用による診断】大血管,末梢血管領域におけるMultidetector CTの有用性

大田英揮, 高瀬圭, 高橋昭喜

断層映像研究会雑誌　31　(1)　10-14　2004/03
Publisher: 断層映像研究会
ISSN： 0914-8663

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Multidetector CT(MDCT)の空間分解能及び時間分解能の飛躍的な向上によって,大血管,及び末梢血管領域にCTAの有用性が大きく高まった.一方,MDCTを十分に活かすためには適切なプロトコールや,患者協力などの撮影に対する工夫が欠かせない.そこで,著者等の施設で通常行われている血管系の撮影法を部位毎に分けて紹介した.読影においては,3D画像を参考にしながら元画像やmultiplanar reformation像の観察をpaging法で丹念に行うことが大切である
【3D image Normals and Abnormalities】心臓 (臨床画像)

壺井匡浩, 高瀬圭, 齋藤春夫, 石橋忠司

臨床画像　20　(3)　309-321　2004/03
MDCTによる消化管穿孔の評価

高瀬圭, 大田英揮, 壺井匡浩, 力丸裕哉, 斉藤春夫, 松橋俊夫, 佐藤明弘, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(2)　S131-S131　2004/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
パラコート中毒47例の胸部画像の検討

一瀬あずさ, 木村啓二, 壺井匡浩, 松橋俊夫, 高瀬圭, 佐藤明弘, 齋藤春夫, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(2)　S164-S164　2004/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
MDCTによる下肢動脈閉塞性疾患の評価 crosssectional MPR imageを中心にして

大田英揮, 高瀬圭, 斉藤春夫, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(2)　S186-S186　2004/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
乳癌の広がり診断におけるMDCTとMRIの比較

嶋内亜希子, 石橋忠司, 齋藤春夫, 佐藤明弘, 山田隆之, 高瀬圭, 松橋俊夫, 壺井匡浩, 高橋昭喜

日本医学放射線学会雑誌　64　(2)　S259-S259　2004/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
Multi-detector Row Computed Tomographyを用いた虫垂炎穿孔の診断能向上についての検討

壺井匡浩, 高瀬圭, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　64　(2)　S286-S286　2004/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
デジタルシネ心血管撮影装置によって皮膚被曝は低減したか?

齋藤春夫, 千田浩一, 高瀬圭, 石橋忠司, 佐藤明弘, 山田隆之, 松橋俊夫, 洞口正之, 高橋昭喜

日本医学放射線学会雑誌　64　(2)　S289-S289　2004/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
膵頭十二指腸及び肝切除術後の大量出血に対する肝動脈塞栓療法の検討

佐藤明弘, 石橋忠司, 齋藤春夫, 高瀬圭, 松橋俊夫, 高橋昭喜

日本医学放射線学会雑誌　64　(2)　S297-S297　2004/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
【胸部・腹部のMRI】心大血管系 (小児科診療)

齋藤春夫, 高瀬圭, 松橋俊夫, 山田隆之, 佐藤明弘, 石橋忠司, 高橋昭喜, 洞口正之, 田中高志

小児科診療　67　(1)　63-71　2004
【重症急性肺血栓塞栓症を考える】 CT・MRI・肺シンチグラフィーの診断価値と限界 (ICUとCCU)

高瀬圭, 斉藤春夫, 石橋忠司, 高橋昭喜

ICUとCCU　28　(3)　167-174　2004
【MDCT利用による診断】大血管,末梢血管領域におけるMultidetector CTの有用性 (断層映像研究会雑誌)

大田英揮, 高瀬圭, 高橋昭喜

断層映像研究会雑誌　31　(1)　10-14　2004
急性肺塞栓症の画像診断,その利点と限界ヘリカルCT (Therapeutic Research)

齋藤春夫, 石橋忠司, 佐藤明弘, 山田隆之, 高瀬圭, 松橋俊夫, 壺井匡浩, 高橋昭喜

Therapeutic Research　25　(6)　1283-1284　2004
【テラバイト時代における大容量画像データへの挑戦】 3D画像を含む大規模画像配信の現状 (映像情報Medical)

川住祐介, 壺井匡浩, 高瀬圭, 石橋忠司, 高橋昭喜

映像情報Medical　36　(9)　962-965　2004
CTで診断しえた閉鎖孔ヘルニアの3例

横山元昭, 金田巌, 古田昭彦, 石井正, 石橋悟, 初貝和明, 後藤均, 檜顕成, 工藤博典, 高瀬圭, 力丸裕也

東北医学雑誌　115　(2)　186-187　2003/12
Publisher: 東北医学会
ISSN： 0040-8700
MDCTによるAdamkiewicz Arteryの術前術後評価親動脈の評価も含めて

高瀬圭, 大田英揮, 齋藤春夫, 高橋昭喜, 赤坂純悦

日独医報　48　(3)　471-471　2003/10
Publisher: バイエル薬品(株)
ISSN： 0912-0351
膜様構造物を伴った動脈管開存症の1例心電同期MDCTの有用性

大田英揮, 高瀬圭, 高山真, 祐川博康, 齋藤春夫, 洞口正之, 高橋昭喜

日独医報　48　(3)　475-475　2003/10
Publisher: バイエル薬品(株)
ISSN： 0912-0351
Assessing the extent of breast cancer by multislice helical CT

K Takase, A Furuta, N Shouji, T Takahashi, K Haga, K Igarashi

RADIOLOGY　225　117-117　2002/11

ISSN： 0033-8419
MDCTを用いた冠動脈の評価

高瀬圭

MDCT徹底攻略マニュアル　156-163　2002
Publisher: メジカルビュー社
Evaluation of the artery of Adamkiewicz by multislice helical CT

K Takase, Y Sawamura, K Igarashi, Y Chiba, K Haga

RADIOLOGY　217　136-136　2000/11

ISSN： 0033-8419
A pitfall of reusing disposable apparatus for endoscopic surgery

Y Sawamura, K Takase, H Saito, S Kikuchi, T Ito

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY　120　(3)　617-617　2000/09

ISSN： 0022-5223
Budd-Chiali syndromeのCT所見

間島一浩, 石橋忠司, 田村亮, 津田雅視, 清治和将, 高橋昭喜, 山田章吾, 高瀬圭, 佐藤明弘

日本医学放射線学会雑誌　60　(2)　S89-S90　2000/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
Bone metastases from carcinoma of the esophagus; their scintigraphic findings

T. Yamazaki, S. Maruoka, S. Takahashi, K. Takase, H. Matsushita, K. Sakamoto, M. Nakamura

Japanese Journal of Clinical Radiology　38　559-564　1993/01/01

ISSN： 0009-9252
Usefulness of magnetic resonance imaging for the diagnosis of aneurysm of sinus of Valsalva

T. Matsuhashi, M. Zuguchi, S. Takahashi, K. Takase, K. Sakamoto, Y. Shoji, K. Niibori, H. Mouri

Japanese Journal of Clinical Radiology　38　391-394　1993/01/01

ISSN： 0009-9252

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Books and Other Publications 21

月刊新医療2025年4月号(第52巻第4号) 巻頭言第84回日本医学放射線学会総会開催にあたって─Radiology for Everyone 高瀬圭［第84 回日本医学放射線学会総会会長］

高瀬圭

株式会社エム・イー振興協会　2025/04/01

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刊行日2025/3/21 ISSN0910--7991
副腎腫瘍取扱い規約第４版

(作成委員会)日本泌尿器科学会・日本病理学会・日本医学放射線学会・日本内分泌学会・日本内分泌外科学会

メディカルレビュー社　2025/03/31

ISBN: 9784779228124
画像診断 2025年1月号 Vol.45 No.1 ビギナーのための胸部画像診断 ―Q&A アプローチ― 2025 すとらびすむす

株式会社Gakkenメディカル出版事業部　2024/12/25

ISBN: 405520115X
原発性アルドステロン症診療マニュアル改訂第4版

編集顧問, 平田結喜緒, 編集, 成瀬光栄, 田辺晶代, 方波見卓行

診断と治療社　2024/06/20

ISBN: 9784787826626
保険収載後の原発性アルドステロン症の経皮的CTガイド下ラジオ波焼灼治療

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 大田英揮

日本内分泌学会雑誌 99(1)　2023/05
経静脈的アブレーションによる原発性アルドステロン症の治療;First-in-Human

高瀬圭, 小黒草太, 尾股慧, 小野美澄, 手塚雄太, 森本玲, 佐藤文俊, 榊原宏幸, 大田英揮

日本内分泌学会雑誌 99(1)　2023/05
画像診断2022年12月号 Vol.42 No.14 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第6回(全6回)最終回薬事承認後から保険収載までその2

株式会社Gakkenメディカル出版事業部　2022/11/25

ISBN: 4780905591
画像診断2022年11月号 Vol.42 No.13 新連載人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第5回(全6回) 薬事承認から保険収載に向けて

株式会社学研メディカル秀潤社　2022/10/25

ISBN: 4780905583
臨床画像2022年10月号 Vol.38 No.10 特別連載沸騰放射線原発性アルドステロン症のラジオ波焼灼治療疾患の基本, 医師主導治験から保険収載まで [第3回] 治験結果から申請, 承認まで

高瀬圭

株式会社メジカルビュー社　2022/09/26
画像診断2022年10月号 Vol.42 No.12 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第4回(全6回)医療機器開発の3つの障壁

高瀬圭

株式会社学研メディカル秀潤社　2022/09/25

ISBN: 4780905575
画像診断2022年9月号 Vol.42 No.10 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第3回(全6回)医療機器開発の自験例と課題

高瀬圭

株式会社学研メディカル秀潤社　2022/08/25

ISBN: 4780905567
【アルドステロンをめぐる臨床課題】原発性アルドステロン症治療におけるラジオ波治療の意義

柳垣聡, 小黒草太, 清治和将, 高瀬圭, 尾股慧, 手塚雄太, 小野美澄, 森本玲, 田中哲洋, 佐藤文俊

糖尿病・内分泌代謝科 55(2)　2022/08
臨床画像2022年8月号 Vol.38 No.8 特別連載沸騰放射線原発性アルドステロン症のラジオ波焼灼治療疾患の基本, 医師主導治験から保険収載まで [第2回] 開発から医師主導治験までの経緯

高瀬圭

株式会社メジカルビュー社　2022/07/26
画像診断2022年8月号 Vol.42 No.9 人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第2回(全6回)Schopenhauerの言葉に学ぶ医療機器開発の3段階

高瀬圭

株式会社学研メディカル秀潤社　2022/07/25

ISBN: 4780905559
画像診断2022年7月号 Vol.42 No.8 新連載人を幸せにする医療機器開発-Schopenhauerの哲学に学ぶ- 第1回(全6回) Shopenhauer(ショーペンハウアー)の思想と医療機器開発の目的

高瀬圭

株式会社学研メディカル秀潤社　2022/06/25

ISBN: 4780905540
臨床画像 2022年6月号 Vol.38 No.6 特別掲載沸騰放射線：原発性アルドステロン症のラジオ波焼灼治療疾患の基本，医師主導治験から保険収載まで［第1回］疾患概念と治療の実際

高瀬圭

株式会社メジカルビュー社　2022/05/26
これから始めるIVR

小黒草太, 鎌田裕基, 高瀬圭

株式会社メジカルビュー社　2022/03/30

ISBN: 4758321116
IVRのすべて

小黒草太, 鎌田裕基, 高瀬圭

メジカルビュー社　2021/03/28
人体のメカニズムから学ぶ画像診断技術学

高瀬圭, 佐藤友美

メジカルビュー社　2020/03/10

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-執筆部分- 1章画像解剖学の基礎 6 泌尿器・生殖器 P. 60-66 4章腹部（消化器、泌尿器、生殖器）の画像診断技術 7 腎・尿路疾患の病態と画像 P. 372-385 8 生殖器疾患の病態と画像 P.386-403 9 その他の病変の病態と画像 P. 404-407
原発性アルドステロン症診療マニュアル

高瀬圭

診断と治療社　2007/11

ISBN: 9784787815804
3次元医用画像作成秘法マニュアル - Zio M900の基礎から臨床での活用法まで

高瀬圭

メジカルビュー社　2004/10

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Industrial Property Rights 8

原発性アルドステロン症の検出方法及びモノクローナル抗体

岡村均, 土居雅夫, 佐藤文俊, 笹野公伸, 森本玲, 伊藤貞嘉, 中村保宏, 高瀬圭

特許第6345596号

Property Type: Patent
高周波治療用カテーテル

高瀬圭, 清治和将, 日本ライフライン株式会社森謙二, 光宗倫彦

Property Type: Patent
診断画像システム

高瀬圭、株式会社島津製作所加治木駿介、能登原大介

Property Type: Patent
診断画像システムおよび診断用情報処理装置

高瀬圭、株式会社島津製作所加治木駿介、能登原大介

Property Type: Patent
バルーンカテーテル、副腎腫瘍のケミカルアブレーション治療装置および副腎静脈採血装置

高瀬圭, 清治和将, 日本ライフライン株式会社森謙二, 光宗倫彦

Property Type: Patent
振動針装置及び針の挿入方法

菊地謙次, 杉山航二郎, 石川拓司, 高瀬圭

Property Type: Patent
診断画像システム、レポート⽣成装置およびレポート⽣成⽅法

高瀬圭、株式会社島津製作所加治木駿介、能登原大介

Property Type: Patent
診断画像システム

高瀬圭、株式会社島津製作所加治木駿介、能登原大介

Property Type: Patent

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Research Projects 30

Elucidation of the pathophysiology of Alzheimer's disease by a novel tau-specific PET tracer, [F18]SNFT-1

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2023/04/01 - 2026/03/31
Pathophysiology of Alzheimer's disease using a novel tau-specific PET tracer, [F18]SNFT-1

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2023/04/01 - 2026/03/31
慢性関節炎の微小血管塞栓術に関する基礎実験

小黒草太, 鎌田裕基, 太田信, 石幡浩志, 大田英揮, 高瀬圭, 権田幸祐, 中村保宏, 佐藤友美

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2022/04/01 - 2025/03/31

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アイビーテック(千葉県成田市)において、コンプライアンスを遵守しながら、獣医師が実験を補佐できる環境で、ブタ2匹の試験を行った。動物用麻酔器による全身管理を行い、デジタルサブトラクションシステムを有する血管造影システムで実験を行った。まず、事前に準備したブタ慢性関節炎モデルに対して、血管造影にて異常血管を確認後,マイクロカテーテルを用いて責任病変となる血管を選択し,バリウムで作成したマイクロ粒子を注入し造影した。その後、高分解能マイクロX線CTを用いて,新生微小血管の三次元的構造のデジタル情報を取得した。3次元的デジタル情報をもとに、Ansys fluentを用いて3次元の流体モデルを作成することに成功した。30個までの塞栓物質を注入したときのシミュレーションを行うこおができた。 同時に、小粒子径金ナノ粒子(Φ2nm)でチエナムへの標識ができることに成功した。高分解能マイクロX線CTを用いて、チエナムへ含有する金ナノ粒子の量によるCT値の違いを確認した。物質の安定性に関して、実験を繰り返した。 また、微小動静脈奇形へのチエナムの有効性に関する検討を含んだ論文を発表した。 Tannai H, Oguro S, Nagao M, Ota H, Takase K. High-flow arteriovenous malformation in the finger with transvenous ethanolamine oleate sclerotherapy using an arterial tourniquet and microballoon occlusion: A case report. Radiol Case Rep. 2023 Mar 20;18(5):1973-1977.
慢性関節炎の微小血管塞栓術に関する基礎実験

小黒草太, 高瀬圭, 石幡浩志, 権田幸祐, 太田信, 中村保宏, 大田英揮, 佐藤友美, 鎌田裕基

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2022/04/01 - 2025/03/31
Quantitative MAO-B imaging of human brain and whole-body organs using [18F]SMBT-1 PET

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2021/04/01 - 2025/03/31
Quantitative brain and whole-body MAO-B imaging with [18F]SMBT-1 and PET

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2021/04/01 - 2025/03/31
Balloon expandable radiofrequency ablation catheter to treat primary aldosteronism

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2020/04/01 - 2023/03/31
蚊の口針と吸血機構を応用した副腎静脈サンプリングおける超選択的採血システムの開発

清治和将, 高瀬圭, 森本玲, 小野美澄

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2020/04/01 - 2023/03/31
Development of imaging diagnosis support system for emergency patients by artificial intelligence

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2019/04/01 - 2023/03/31
Early diagnosis of atherosclerosis by accurate ultrasonic measurement of surface roughness of internal elastic membrane

Kanai Hiroshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Institution: Tohoku University

2019/10/07 - 2022/03/31

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We have developed a method to exclude unnatural shapes at both ends of the surface shape measured for each beam by limiting the analysis range to the monotonically increasing part of the lateral displacement when measuring the surface shape for each beam. Furthermore, by interpolating the surface shape measured for each beam for each 1-micron lateral position, the error power is calculated with equal weight at all lateral positions of the surface shape measured for each beam, and the height is adjusted appropriately. We also developed a method. As a result, it became possible to obtain carotid artery surface roughness in vivo by reducing the beam-to-beam variation after adjusting the height of the surface shape measured for every single beam. These results were obtained by referring to Professor Wilhjelm's many years of research.
Ultrasonic visualization of propagation of electrical excitation causing contraction by measuring human myocardial response

Kanai Hiroshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2019/06/28 - 2022/03/31

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In the early stage of ischemic heart disease, the ischemic region can avoid myocardial necrosis by rapidly reperfusing the coronary arteries. Therefore, rapid identification of the ischemic region is important, and local and highly accurate velocity estimation is the key to the evaluation of local myocardial contraction characteristics using ultrasound. In this study, we analyzed the received ultrasonic signal at multiple frequencies and proposed a speed estimation method using ultrasonic phase differences at multiple different frequencies. This proposed method can reduce the effects of attenuation and interference as described above without performing spatial averaging, and local velocity estimation is possible. The proposed method can estimate the velocity with a shorter window width than the conventional method, and can measure the local velocity distribution and the local myocardial strain rate.
MRIアーティファクトフリーとX線視認性を両立させた新規医療用形状記憶合金の創製

金高弘恭, 細田秀樹, 高瀬圭, 沼野智一, 古谷真衣子

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(B)

Category: 基盤研究(B)

Institution: 東北大学

2019/04/01 - 2022/03/31

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近年、形状記憶効果と超弾性特性を併せ持つ形状記憶合金が着目されるようになった。しかしながら、現在、唯一実用化されているNiTi合金は、生体安全性への懸念、MRI撮影やX線CT撮影時の金属アーティファクト、さらに、血管X線撮影では低い視認性など、臨床的な問題が指摘されている。そこで本研究では、人体と同じ体積磁化率を有し、かつ重元素で構成される形状記憶合金としてAuCuAl合金を作製する。材料特性および生体適合性についての評価結果を材料作製段階までフィードバックしながらMRIアーティファクトフリーとX線視認性を両立させた合金を開発し、その生物学的安全性と臨床的有効性を検証する。本研究では、最新の材料学技術に基づく合金設計および組成制御により、MRIアーティファクトフリーとX線視認性を両立させた新規医療用形状記憶合金を創製することを目的とした。具体的には、人体と同じ体積磁化率を有し、かつ重元素で構成される形状記憶合金としてAuCuAl合金を作製する。材料特性および生体適合性についての評価結果を材料作製段階までフィードバックしながらMRIアーティファクトフリーとX線視認性を両立させた合金を開発し、その生物学的安全性と臨床的有効性を検証した。本年度の研究成果として、開発したAuCuAl合金に対する性能評価を行った。具体的には、①形状可変機能（形状記憶・超弾性）および機械的特性評価、②MRIアーティファクト評価、③X線視認性評価、④生体適合性評価により開発合金の性能評価を行った。
Development of diagnostic method for breast cancer axillary lymph node micrometastasis by three-dimensional ultrahigh-frequency contrast ultrasound

TAKASAWA CHIAKI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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Breast axillary lymph node metastasis is divided into coarse metastasis with a lesion size of 2 mm or more and micrometastasis with a size of less than 2 mm. Since the treatment methods differ between the two, it is important to determine whether the metastasis is micrometastasis or gross metastasis in order to select an appropriate treatment and maintain the patient's QOL. We (1) compare one-to-one correspondence images with intraoperative contrast-enhanced ultrasound and pathological findings, (2) develop three-dimensional ultrahigh-frequency contrast-enhanced ultrasound imaging and perfusion defect detection methods for lymph nodes, and (3) preoperative three-dimensional ultra-high-frequency contrast-enhanced. We confirmed the ability to detect lymph node micrometastasis by ultrasound, and established a method for detecting lymph node micrometastasis by contrast-enhanced ultrasound.
Development of MRI diffusion-weighted imaging technology for rapid intraoperative stump diagnosis of breast cancer

Mori Naoko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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Using the latest clinical MRI system, MRI imaging including diffusion-weighted imaging was performed preoperatively, and the images and pathology were compared in about 46 cases. The visual signal and diffusion coefficient of the sample diffusion-weighted images of the lesions of normal mammary gland, ductal carcinoma in situ and invasive cancer were obtained, and it was verified whether the tumor part could be correctly discriminated compared with the normal mammary gland. The diffusion coefficient was higher in the order of invasive cancer, non-invasive cancer, and normal mammary gland. The area ratio of the pathological interstitium was significantly correlated with the diffusion coefficient, but the area ratio of cytoplasm and nucleus did not correlate with the diffusion coefficient. The number of cells and nuclei did not correlate with the diffusion coefficient.
Fluid mechanical basic research for the treatment of dissecting aortic aneurysms with multi-layered blood flow control stents

YUSUKE SUZUKI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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A dissected blood vessel model was created. We designed a pulsatile flow circulation circuit incorporating a pseudo-dissected blood vessel model. Hemodynamic analysis was performed before and after placing the MFM stent in the true lumen. As a result, a pulsating water flow was observed in the false lumen before the MFM stent was placed, and an accelerated water flow was observed in the entry part. On the other hand, after the MFM stent was placed, the laminar flow was almost laminar, and no accelerated water flow was observed. From the above, it was considered that the water flow into the false lumen remains, but the water flow flowing into the false lumen through this MFM stent is rectified, the turbulence is reduced, and the shear stress applied to the false lumen wall is reduced. These results indicate that the MFM stent may be useful as a treatment for dissecting aortic aortic aneurysm.
Radiation cognitive impairment: Elucidation of onset mechanism by Advanced MR and verification by animal model

Mugikura Shunji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2017/04/01 - 2021/03/31

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In this study, we will elucidate the onset mechanism of radiation cognitive impairment using Advanced MRI in long-term survivors of childhood cancer and verify it in post-irradiation cognitive impairment mice. In childhood cancer long-term survivors, microstructural changes and brain activity changes were quantified using Advanced MR including T2 star. In addition, the same subject was subjected to an adult function test and a function test, which are cognitive function tests, and the test results were quantified and analyzed. At the same time, a QOL evaluation was performed on the same subject using a questionnaire. In addition to the above cognitive function test and QOL evaluation, data including basic patient information was organized.
A study on noninvasive ultrasonic measurement of visco-elastic property between blood pressure and strain

KANAI Hiroshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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To establish an evaluation index for vascular endothelial function, we developed an ultrasonic probe that can measure changes in blood pressure and blood vessel diameter at the same position in the radial artery. Based on phantom experiments, the pressure waveforms measured using the piezoelectric effect of the ultrasonic probe element and those using a pressure sensor exhibited a high correlation. We confirmed the continuous measurement of the relationship between changes in blood pressure and diameter to estimate the changes in viscoelasticity by calibrating the output from the probe element to the absolute blood pressure values in advance. We measured the changes in the viscoelastic moduli of several subjects at rest and examined the accuracy of the estimated values. This study demonstrated the possibility of measuring changes in the viscoelastic moduli of the radial arterial wall due to flow-mediated dilation using the developed ultrasonic probe.
Transvenous radiofrequency ablation system for the treatment of primary aldosteronism.

Kei Takase

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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We initially developed flexible type metallic ablation catheter with coop-tip system which can be inserted via a guiding sheath using over-the-wire technique. We evaluated electrical and mechanical safety, reachability to left adrenal vein via femoral vein, and ablative volume to make improvement of the system. The ablation performance was evaluated by gel-model study and ex-vivo ablation of bovine adrenal gland to establish dosimetry table. Ablation volume under blood perfusion to adrenal gland will be evaluated by in-vivo ablation of porcine adrenal grand, in which protocol of blood pressure stabilization during the ablation should also be established. Reachability of the system to human adrenal gland was also evaluated by using a real-size vascular model based on 3D-CT data. After development of this system, most of the primary aldosteronism patients will be treated low-invasively leading to reduction of severe cardiovascular complications and medical cost.
Development of minimally invasive treatment of primary aldosteronism using adrenal vein sampling technique

SEIJI KAZUMASA

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2016/04/01 - 2020/03/31

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We developed a micro-balloon catheter that can be inserted and placed in the adrenal vein and can be occluded the adrenal vein. First, the operation performance of the micro-balloon catheter was evaluated using a 3D blood vessel model, and then the adrenal vein closure performance by balloon and the necrosis range of the adrenal tissue by intravenous infusion of absolute ethanol were measured using porcine adrenal glands, and the effects on surrounding tissues were evaluated. Most of the adrenal tissue was found to have coagulated necrosis with congestion and bleeding. Little damage was observed in the peri-adrenal tissues. Evaluation of small-sized microcatheter designed to obstruct the adrenal tributary vein using porcine adrenal glands revealed damage to the small-diameter vein due to balloon dilatation and absolute ethanol leakage from the damaged site. Therefore, we were unable to stably necrotic adrenal tissue.
Primary aldosteronism: Establishment of tissue-sparing adrenalectomy according to the results of segmental adrenal venous sampling

ISHIDOYA SHIGETO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2016/04/01 - 2019/03/31

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We evaluated whether laparoscopic adrenalectomy (ADX) would improve general health-related quality of life (HRQOL) and nocturia for patients with primary aldosteronism (PA). A total of 173 patients were asked to fill out the HRQOL questionnaires RAND 36-Item Health Survey (SF-36) and International Prostate Symptom Score (I-PSS) preoperatively. Patients were associated with significantly low score of General Health domain compared with normal Japanese population. Among 4 physical domains, General Health scored significantly higher throughout the post-operative period. Among 4 mental domains, scores of Vitality, Social Function, and Mental Health significantly increased after ADX. Patients with PA were suffered from average 2.6 times of urination per night, which significantly decreased after ADX. ADX for PA patients generally improved HRQOL for 2 years. Patients with PA were associated with nocturia which was significantly recovered by ADX.
Installation and utilization situation of MRI in Japan

Sato Miho, TAKASE Kei, INABA Yohei, MORI Naoko, NAGASAKA Tatsuo, HIKICHI Takeo

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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Even though it is frequently cited that Japan has the highest number of MRIs per person, we rarely find studies evaluated those utilities and installations. This study aims to survey MRI installation and utilities in Japan. We mailed questionnaire to 5,437 facilities have MRI(s) and we received 2,272 responses (41.8% response rate). Questions include the type of facility, the detail information about their installed MRI, and their utilization such as operation rate per day, target of scans, scan protocol, staffing, etc. From a statistical analysis of the collected data, many of the clinics and the hospitals with a small number of beds did not have a full-time radiologist or a radiographer. This data will be effective for future discussion of MRI installation in Japan.
Recommended protocol for breast diffusion weighted images and standardization of ADC values

Maekawa Yui

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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Although the correlation with the prognostic factor of breast cancer is known as the improvement of the specificity in the discrimination between benign and malignant as the usefulness of diffusion weighted images in breast cancer, it is stated that the sequence is expected at the research level in the future Only. In the background, DWI believes that standardization is difficult, distortion in the breast region by EPI method, noise, magnetic susceptibility artifacts. In this research, DWI imaging of the TSE method was taken as a new method against the conventional EPI method, and the image quality and the diagnostic ability were compared. As a result, the TSE method is superior to the EPI method in terms of improving SNR and distortion, and imaging of DWI using the TSE method is considered to be an imaging method leading to standardization.
Development of early diagnosis and treatment for lymph node metastasis

Kodama Tetsuya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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There are few pre-clinical studies of early diagnosis and treatment for lymph node (LNM). The reasons mainly are due to the lack of a noninvasive imaging system capable of monitoring metastasis over time in an appropriate animal model. We developed MXH10/Mo/lpr mice, which develop systemic swelling of LNs up to 10 mm in diameter. Here we show using MXH10/Mo/lpr mice that we developed an ultrasound/micro-CT system which consists of a high-frequency ultrasound system and a micro-CT system, and a lymphatic drug delivery system (LDDS) using acoustic liposomes (ALs) and ultrasound (US). Vascular distribution in the metastatic LNs can qualitatively expressed by the ultrasound/micro-CT system at the early stage of LNM. While, the LDDS using US and ALs delivered doxorubicin into metastatic LNs, resulting in an effective treatment for early metastatic LNs. We anticipate that our methodology could be applied clinically for early metastatic LNs.
A Study on Ultrasound Accurate Measurement of Luminal Surface Roughness of Human Carotid Artery for Early Diagnosis of Atherosclerosis

Kanai Hiroshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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The diagnosis of atherosclerosis in the early stage is crucial for preventing degeneration of arteries. In the early stage of atherosclerosis, the arterial wall becomes rough due to endothelial cell proliferation and degeneration of the internal elastic layer. For the early diagnosis of atherosclerosis, our group has proposed a method to estimate the micron-order luminal surface roughness of the carotid artery. In the present study, a technique was developed that suppresses error in estimating surface roughness caused by the movement of a carotid artery during one cardiac cycle. The average surface roughness of the carotid artery estimated by the proposed method was 2.33 μm in three young subjects (from 20 to 30 years old) and 3.36 μm in three older subjects (from 50 to 65 years old). These results show the high potential of the proposed method for accurate estimation of the minute surface roughness of the carotid artery.
Quantification of breast cancer microenvironment by three dimensional integration of micro bubble contrast ultrasound and MRI image

Takasawa Chiaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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The quantitative method of contrast ultrasound is currently equipped with time intensity curve analysis in clinical models. Peak intensity and area under the curve are calculated as parameters, and it is reported that these correlate with MVD. As a new method, we focus on a certain pixel, measure how the color of pixel changes in the time axis direction, divide one with a large degree of change and one with a small change by threshold．We developed a method to detect things as detected pixels of the contrast agent. Finally, an area ratio (enhancement area ratio) of the region where the contrast medium is detected is calculated with respect to the region of interest. In this study, we clarified that the enhancement area ratio correlates with the pathological MVD of invasive cancer.
Primary aldosteronism: Assessment of tissue-sparing adrenalectomy according to the results of segmental adrenal venous sampling

ISHIDOYA SHIGETO, KAWASAKI YOSHIHIDE, TAKASE KEI, KAIHO YASUHIRO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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We investigated whether tissue-sparing laparoscopic bilateral adrenal surgery was applicable or not for patients with bilateral primary aldosteronism (PA). Endocrinological examination was conducted for patients with hypertension and PA patients were selected. Segmental adrenal venous sampling (sAVS) was performed for PA patients. Then bilateral intara-adrenal venous map has become apparent which enabled us to recognize the aldosterone-hypersecreting regions. Urologists performed laparoscopic bilateral adrenal surgery with partial conservation (LBASpc) for selected 42 patients with bilateral PA disease. All patients were normalized plasma aldosterone concentration (PAC) and 98 % achieved reduction of antihypertensive medication after LBASpc. Moreover, 72% of patients has become free from corticoid replacement therapy (CRT) after surgery. Preoperative PAC was the risk factor for persistent CRT. The study indicated that LBASpc could be applicable for selected patients with bilateral PA.
Development of a new catheter for segmental adrenal venous sampling

Seiji Kazumasa, Takase Kei, Morimoto Rei, Oota Makoto, Haga Yoichi, Nakamura Yasuhiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04/01 - 2016/03/31

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Segmental venous sampling is essential for diagnosis and localization of aldosterone producing adenomas. In segmental adrenal venous sampling (S-AVS), blood samples are obtained with microcatheters inserted into the target venous tributary. However, it sometimes happen that blood samples cannot be obtained through catheters. In such cases, it is assumed that suction pressure deforms venous wall, then catheter tip is considered to be occluded. To our knowledge, there has been no study concerning hemodynamics in venous catheter blood sampling. The purpose of this study is to simulate the blood flow in venous blood sampling using synthetic very small blood vessel or Computational Fluid Dynamics method and to search the catheter tip shape suitable for the procedure. The prototype of microcatheter whose tip was shaped suitable for S-AVS was created. And then, the performance of the microcatheter was evaluated in an animal study.
Cost-Effectiveness Analysis of the Hypertension Treatment; pursuing cost reduction of national health expenditure

SATO MIHO, KAKIHARA Hiroaki, TAKASE Kei, SEIJI Kazumasa, MORIMOTO Ryo

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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Approximately 10% of cases of hypertension in Japan are caused by primary aldosteronism (PA), amounting to about 4 million patients in total. Primary aldosteronism due to unilateral aldosterone hypersecretion is potentially curable by adrenalectomy. The clinical benefits of identifying and treating PA have been reported internationally, but its cost-effectiveness is unclear. We examined whether diagnosing and treating hidden PA in hypertensive population was cost-effective compared with suboptimal treatment. We established a Markov decision model based on plausible clinical pathways and prognoses of PA. The result was cost-effective, but our findings were sensitive to the outcomes of screening and treatment, and the costs of continuous or periodic medication for hypertension and the treatment of stroke and its complications.
Development of minimally-invasive interventional radiological therapy of primary aldosteronism based on adrenal venous sampling.

TAKASE KEI, OOTA Makoto, MORIMOTO Ryou, SEIJI Kazumasa, SATOU Fumitoshi, SATOU Miho

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2011/04/01 - 2014/03/31

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Real-size vascular model including adrenal venous tributaries was generated, which was utilized for simulation of catheterization. Experimental study using bovine adrenal gland showed that 3 insertion patterns of bipolar needles enables complete ablation of adrenal adenoma with 10 to 25-mm in diameter. Adjacent organ with 5-mm intervening adipose tissue was preserved. Initial clinical interventional radiological treatment achieved normalization of plasma aldosterone level and amount in 24-hour urine specimen. Cost-effectiveness of this treatment was also proven.
Preoperative evaluation of the artery of Adamkiewicz of Japa ese and European patients using MDCT and MRI

TAKASE Kei

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2007 - 2010

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Accurate localization of the artery of Adamkiewicz (AKA)is important in planning treatment of patients with thoracoabdominal aortic disease. We assessed the usefulness of three-dimensional imaging devices such as multi-detector-row helical computed tomography (MDCT)and 3 Tesla (T)MRI in the preoperative evaluation of the artery of Adamkiewicz (AKA)and its parent artery. 3T-MRA was also performed in patients whose AKA was difficult to visualize because of artifact from bony structures.

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Media Coverage 51

第84回日本医学放射線学会総会の開催にあたって

病院新聞社　病院新聞第2840号　1

2025/04/10

Type: Newspaper, magazine
放射線医療現場市民講座で体験

河北新報社　河北新報　みやぎワイド（14）

2024/11/17

Type: Newspaper, magazine
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座が開催 ——「来て見て触ってみよう！放射線医療」をテーマに，中高生らが体験会に参加

株式会社インナービジョン　インナビネット　取材報告 >新製品発表・学会などの通常取材

2024/11/01

Type: Internet
放射線診断を分かりやすく説明 10月27日仙台・アエルで市民講座

河北新報社　河北新報　6右下経済&暮らし情報河北Bizナビピックアップ

2024/10/10

Type: Newspaper, magazine
放射線診断を分かりやすく説明 10月27日仙台・アエルで市民講座

河北新報社　河北 Biz ナビ　ピックアップ

2024/10/10

Type: Promotional material
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』開催のお知らせ（10/27開催）

東北大学病院　新着情報>イベント

2024/09/30

Type: Other
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』開催のお知らせ（10/27開催）

東北大学大学院医学系研究科・医学部　イベント

2024/09/30

Type: Other
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座「来て見て触ってみよう！放射線医療」

河北新報社　こども新聞週刊かほピョンプレス　8下段

2024/09/29

Type: Promotional material
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』（10/27開催）

東北大学　2024年のイベント

2024/09/20

Type: Other
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座「来て見て触ってみよう！放射線医療」

河北新報社　河北ウイークリーせんだい別冊ジュニアr.2024年秋号　9

2024/09/19

Type: Promotional material
第84回日本医学放射線学会「レントゲンの日記念」市民公開講座「来て見て触ってみよう！放射線医療」

河北新報社　河北ウイークリーせんだい2024.9.19　9下段

2024/09/19

Type: Promotional material
河北新報「気になる症状すっきり診断」に放射線診断科科長高瀬圭教授の記事が掲載されました

東北大学病院　お知らせ

2024/05/24

Type: Other
気になる症状すっきり診断（１６９）なかなか治らない高血圧／特別な治療、必要な例も

河北新報社　河北新報　朝刊くらし総合（18）

2024/05/24

Type: Newspaper, magazine
血圧に関する様々な情報を提供する「高血圧チャンネル」

株式会社デイリースポーツ案内広告社（日本経済新聞）　Biz Life Style仙台版　P7（左上）

2024/02/23

Type: Promotional material
「読売新聞教育ネットワーク主催の高校生向けオンラインセミナー」が読売新聞朝刊に掲載されました

東北大学大学院医学系研究科・医学部　ニュース

2024/01/16

Type: Other
医療、医師の本質に迫る高校生向けオンラインセミナー 6大学で

読売新聞東京本社　読売新聞　27 特別面

2024/01/15

Type: Newspaper, magazine
【宮城】AIの発展と共に放射線科医のニーズはますます高まる‐高瀬圭・東北大学病院放射線診断科教授に聞く◆ Vol.2溝部鈴の『東北大学病院／医学部の現在』

エムスリー株式会社　m3.com ニュース・医療維新　地域情報（県別）地域ニュース

2022/12/02

Type: Internet
【宮城】放射線診断医が難治性高血圧症の新治療法を開発‐高瀬圭・東北大学病院放射線診断科教授に聞く◆ Vol.1溝部鈴の『東北大学病院／医学部の現在』

エムスリー株式会社　m3.com ニュース・医療維新　地域ニュース地域情報（県別）

2022/11/25

Type: Internet

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共同研究・競争的資金等の研究課題：経静脈的ラジオ波焼灼による原発性アルドステロン症の低侵襲治療法
「外科的手術をしなくて済む」体への負担少ない高血圧の新治療法東北大学病院

Yahoo! JAPAN　Yahoo! ニュース

2022/05/23

Type: Internet
「外科的手術をしなくて済む」体への負担少ない高血圧の新治療法東北大学病院

TBS　NEWS DIG(JNN DIG)

2022/05/23

Type: Internet
「外科的手術をしなくて済む」体への負担少ない高血圧の新治療法東北大学病院

tbc東北放送　Nスタみやぎ（TBS NEWS DIG）

2022/05/23

Type: Internet
東北大学大学院医学系研究科放射線診断学分野高血圧引き起こす疾患の低侵襲治療開発

関東医事新報社　医事新報　第693号 21 宮城講座クローズアップ

2022/02/20

Type: Newspaper, magazine
気になる症状すっきり診断東北大病院専門ドクターに聞く 113原発性アルドステロン症副腎の腫瘍電流で焼灼ホルモン過剰に

河北新報社　河北新報（19）くらし

2021/11/26

Type: Newspaper, magazine
難治性高血圧に新治療法原発性アルドステロン症原因の腫瘍焼き根治へ

長崎新聞社　長崎新聞　健康 10

2021/10/10

Type: Newspaper, magazine
難治性高血圧に新治療法原発性アルドステロン症で保険適用東北大教授開発原因腫瘍を電流で焼く

株式会社高知新聞社　高知新聞　（17）

2021/09/17

Type: Newspaper, magazine
原発性アルドステロン症難治性高血圧に新治療法原因腫瘍電流で焼き切る

宮崎日日新聞社　宮崎日日新聞　くらし 21

2021/09/14

Type: Newspaper, magazine
難治性高血圧に新治療法原発性アルドステロン症原因の腫瘍を電流で焼く

埼玉新聞社　埼玉新聞　生活情報医療サイエンス（13）

2021/09/08

Type: Newspaper, magazine
原因の腫瘍を電流で焼く難治性高血圧に新治療法原発性アルドステロン症医療保険適用に

株式会社中日新聞社　東京新聞　健康 2（夕刊）

2021/09/08

Type: Newspaper, magazine
【研究成果】難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ−

東北大学大学院医学系研究科・医学部　ニュース

2021/09/08

Type: Other
難治性の高血圧症原発性アルドステロン症新治療法に保険適用原因の腫瘍電流で焼く

株式会社下野新聞社　下野新聞　くらし 18

2021/09/07

Type: Newspaper, magazine
根治期待の新治療法原発性アルドステロン症 6月から保険適用腫瘍を高周波電流で焼く

株式会社茨城新聞社　茨城新聞　健康生活（16）

2021/09/02

Type: Newspaper, magazine
難治性高血圧に新治療法原因の腫瘍を電流で除去原発性アルドステロン症

新日本海新聞社　日本海新聞　くらし（11）

2021/09/02

Type: Newspaper, magazine
体の負担軽い「高血圧」の新たな治療法

Yahoo! JAPAN　Yahoo! ニュース

2021/09/02

Type: Internet
特集高血圧治療の最前線『体の負担軽い「高血圧」の新たな治療法』

tbc東北放送　Nスタみやぎ

2021/09/02

Type: TV or radio program
難治性高血圧に新治療法針刺し腫瘍を電流で焼く原発性アルドステロン症

千葉日報社　千葉日報（日刊）　健康（12）

2021/08/29

Type: Newspaper, magazine
難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ −

東北大学病院臨床研究推進センター　プレスリリース

2021/08/24

Type: Other
難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ −

東北大学　2021年 | プレスリリース・研究成果

2021/08/24

Type: Other
難治性高血圧症の新治療法が保険適用に −高血圧の原因ホルモンを手術なしで直接断つ−

東北大学病院　プレスリリース

2021/08/24

Type: Other
ここまで進んだ最新治療「原発性アルドステロン症」のラジオ波焼灼療法

産経新聞社　夕刊フジ　（8）

2021/08/17

Type: Newspaper, magazine
気になる症状すっきり診断東北大病院専門ドクターに聞く 67子宮筋腫と言われたら

河北新報社　河北新報（20）

2019/12/06

Type: Newspaper, magazine
“がんの疑い見落とし”再発防止策進まずその背景は

NHK　首都圏ネットワーク

2019/01/21

Type: TV or radio program
【気になる症状すっきり診断東北大病院専門ドクターに聞く】⑱健診で「腎臓に腫瘍の疑い」

河北新報社　河北新報（25）

2017/11/17

Type: Newspaper, magazine
河北新報・東北大「東北みらいプロジェクト」高血圧早めの治療を-薬の効かない高血圧に立ち向かう

河北新報社　河北新報

2017/03/31

Type: Newspaper, magazine
医療機器開発産業の最前線

東北放送

2016/10/11

Type: TV or radio program
みちのくワイド東北の医療機器製造、好調復興予算背景に医師と企業連携福島県、参入・海外進出も支援

朝日新聞社　朝日新聞　第2宮城 28

2015/03/03

Type: Newspaper, magazine
薬が効かない高血圧への挑戦

TBS　報道特集

2014/10/11

Type: TV or radio program
くらしナビライフスタイル「ホルモン原因」高血圧に新治療

毎日新聞社　毎日新聞　くらしナビ 15

2014/05/27

Type: Newspaper, magazine
高血圧を引き起こす “原発性アルドステロン症” の新たな治療法

NHK仙台　てれまさむね

2014/05/20

Type: TV or radio program
原発性アルドステロン症の新しい治療

NHK　ニュース7

2014/05/18

Type: TV or radio program
高血圧症に新治療法東北大病院患者の負担減に期待

讀賣新聞社　讀賣新聞　宮城2 30

2014/04/18

Type: Newspaper, magazine
高血圧引き起こす「原発性アルドステロン症」東北大新治療法2例臨床

河北新報社　河北新報

2014/04/15

Type: Newspaper, magazine

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Academic Activities 4

第84回日本医学放射線学会「レントゲンの日記念」市民公開講座『来て見て触ってみよう！放射線医療』

AER5階多目的ホール（中小企業活性化センター）

2024/10/27 - 2024/10/27

Activity type: Other

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共催公益社団法人日本医学放射線学会、東北大学大学院医学系研究科放射線診断学分野、東北大学病院後援宮城県教育委員会、仙台市教育委員会、河北新報社協賛アミン株式会社、キヤノンメディカルシステムズ株式会社、コニカミノルタジャパン株式会社、テルモ株式会社、株式会社フィリップス・ジャパン、富士フイルムメディカル株式会社、GEヘルスケア・ジャパン株式会社協力公益財団法人仙台観光国際協会
東北みらいプロジェクトレクチャーシリーズ「血圧管理で健康長寿」. 薬の効かない高血圧に立ち向かう～放射線診断科医とIVRの挑戦～

東北大学川内キャンパス

2017/03/18 - 2017/03/18
第51回ドクターサーチみやぎ健康セミナー市民公開講座「高血圧～3つのチェックポイント～」

仙台メディアテーク

2015/07/12 - 2015/07/12
高校生向け医療体験プログラム大学プログラム未来の医療を創る君へオンラインセミナー第1回東北大学画像で病気を診て、針と管で治療する―放射線診断医の世界―

2023/10/07 -

Activity type: Other

Other 6

日本核医学会 PET核医学認定医
心臓血管放射線研究会（幹事）
日本脈管学会脈管専門医（評議委員）
日本インターベンショナルラディオロジー学会IVR専門医
日本超音波医学会専門・指導医
日本医学放射線学会放射線診断専門・指導医（理事）

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