東北大学研究者紹介

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アイザワ　トシミ

相澤　俊峰

Toshimi Aizawa

所属

大学院医学系研究科　医科学専攻　外科病態学講座（整形外科学分野）

職名

教授

学位

医学博士（東北大学）

researchmap

https://researchmap.jp/read0052212

J-GLOBAL ID

200901051229097360

委員歴 10

日本整形外科学会　理事

2025年5月～継続中
日本運動器学会　評議員

2022年7月～継続中
日本腰痛学会　評議員

2021年10月～継続中
東日本整形災害外科学会　理事

2021年5月～継続中
東北整形災害外科学会　幹事

2021年4月～継続中
日本整形外科学会　代議員

2017年5月～継続中
東日本整形災害外科学会　評議員

2015年9月～継続中
日本脊椎脊髄病学会　評議員

2011年4月～継続中
東北整形災害外科学会　事務局長

2004年1月～ 2011年12月
日本脊椎脊髄病学会　理事

2024年4月～

︎全件表示 ︎最初の5件までを表示

所属学協会 3

日本脊椎脊髄病学会(2010/04-2014/04 評議員)
日本整形外科学会(2008/07- 脊椎内視鏡下手術医療安全対策小委員会委員)
日本整形外科学会(2006/05-2008/05 脊椎内視鏡下手術インシデントワーキンググループメンバー)

研究キーワード 4

脊椎手術
胸椎後縦靱帯骨化症
軟骨細胞
成長軟骨板

研究分野 1

ライフサイエンス / 整形外科学 / 脊椎手術

論文 368

Smoking increases the risk of early postoperative infection after elective total hip arthroplasty: Evidence from a Nationwide Japanese database. 国際誌

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Hideki Fukuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

International orthopaedics　2026年2月11日

DOI： 10.1007/s00264-026-06747-w 　

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PURPOSE: Smoking is a potentially modifiable risk factor for adverse outcomes after total hip arthroplasty (THA), but evidence on early postoperative complications in Asian populations remains limited. This study examined the association between smoking and early postoperative complications after elective THA using a nationwide inpatient database in Japan. METHODS: This retrospective cohort study analysed data from the Japanese Diagnosis Procedure Combination (DPC) database between December 2011 and March 2023. Patients undergoing elective primary THA for osteoarthritis, osteonecrosis of the femoral head, or rheumatoid arthritis were included. Smoking status was identified using administrative codes. One-to-one propensity score matching was used to balance baseline characteristics between smokers and non-smokers. Primary outcomes were early postoperative surgical complications, medical complications, and in-hospital mortality. Dose-dependent effects were assessed using the Brinkman Index, with heavy smoking defined as ≥ 600. RESULTS: After propensity score matching, 52,551 patients were included in each group. Smoking was associated with a higher risk of postoperative infection (odds ratio [OR] 1.31; 95% confidence interval [CI] 1.15-1.49; p < 0.001) and a lower likelihood of blood transfusion (OR 0.83; 95% CI 0.80-0.85; p < 0.001). No significant associations were observed with dislocation, periprosthetic fracture, wound dehiscence, reoperation, major medical complications, or in-hospital mortality. Heavy smoking (Brinkman Index ≥ 600) was not associated with postoperative complications. CONCLUSIONS: Smoking was associated with an increased risk of early postoperative infection following elective THA, but not with other major complications or in-hospital mortality. Smoking cessation should be considered an important component of perioperative optimisation.
JP1.4 A biomechanical evaluation of hip joint stability after transverse versus longitudinal capsulotomy: a cadaveric analysis

Hidetatsu Tanaka, Kazuyoshi Baba, Yu Mori, Yasuaki Kuriyama, Ryuichi Kanabuchi, Toshimi Aizawa

Journal of Hip Preservation Surgery　12　(Supplement_2)　ii38-ii39　2025年12月22日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/jhps/hnaf069.118 　

eISSN：2054-8397

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Abstract Introduction The biomechanical effects of transverse and longitudinal capsulotomy on hip joint stability in arthroscopy have not been thoroughly investigated. This study used fresh-frozen cadavers to evaluate whether rotational stability and traction resistance differ between these two capsulotomy orientations. Methods Twelve hips from six fresh-frozen cadavers with intact femurs and pelvises were tested under three conditions: intact, post-capsulotomy, and post-repair. Two capsulotomy patterns were created: a 4 cm transverse capsulotomy assuming inter-portal capsulotomy and a longitudinal capsulotomy. Six hips underwent a transverse capsulotomy, and six underwent a longitudinal capsulotomy. The pelvis was fixed using a wooden plate, and an intramedullary nail was inserted into the femur. To assess rotational stability, internal and external torques of 5 Nm were applied at hip extension angles of 15° and 0°, and at hip flexion angles of 15°, 30°, 45°, and 60°. To evaluate traction resistance, a 200 N axial traction force was applied at flexion angles of 0°, 30°, 45°, and 60°. Results External rotation laxity increased significantly at all flexion angles following transverse capsulotomy, and only at 0° after longitudinal capsulotomy. The change in external rotation laxity was significantly greater in transverse capsulotomy at 15° of hip extension and 0° than longitudinal capsulotomies in post-capsulotomy compared to intact conditions. Internal rotation laxity did not significantly increase after the both types of capsulotomies and following capsular repair. Separation distance under traction force increased significantly after both types of capsulotomies. The separation distance with post-capsulotomy and post-repair at 0° flexion, and with post-repair at 30° flexion was significantly greater in the transverse group, but no significant differences observed in other positions or conditions. Conclusions This cadaveric study demonstrated that vertical (longitudinal) capsulotomy results in less external rotation and traction laxity - particularly at 15° extension and 0° flexion - than horizontal (transverse) capsulotomy. These differences were partially retained even after capsular repair. While standard repair improves overall joint stability, surgeons should note that the longitudinal incision tends to be more stable at lower levels of hip flexion.
Computer-assisted total hip arthroplasty reduces early complications based on Japanese nationwide medical claims data

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Hiroaki Kurishima, Hiroki Kawamata, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Archives of Orthopaedic and Trauma Surgery　145　(1)　2025年11月12日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s00402-025-06116-z 　

eISSN：1434-3916

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Abstract Introduction: Computer-assisted (CA) surgery is increasingly adopted in total hip arthroplasty (THA) to enhance implant positioning accuracy. However, robust evidence regarding its impact on postoperative complications compared with manual THA (M-THA) remains limited. This study evaluated the association between CA-THA and early postoperative complications using a large Japanese database. Materials and Methods: We analyzed 336,624 THA cases recorded in the Japanese Diagnosis Procedure Combination (DPC) database between December 2011 and March 2023. Of these, 242,067 underwent M-THA and 94,557 underwent CA-THA. One-to-one propensity score matching was performed to adjust for age, sex, body mass index, comorbidities, and diagnosis. Outcomes included surgical complications, medical complications, and in-hospital mortality. Results: After matching, 93,887 patient pairs were analyzed. Compared with M-THA, CA-THA was associated with lower odds of dislocation (OR 0.667, 95% CI 0.556–0.786, p < 0.001), infection (OR 0.763, 95% CI 0.687–0.848, p < 0.001), and re-operation (OR 0.822, 95% CI 0.732–0.922, p < 0.001), but higher odds of periprosthetic fracture (OR 1.301, 95% CI 1.118–1.514, p < 0.001). No significant differences were found in medical complications or mortality. Conclusions: In this nationwide cohort, CA-THA was associated with reduced risks of dislocation, infection, and reoperation, but an increased risk of periprosthetic fracture compared with M-THA. Further research should clarify optimal indications and refine patient selection criteria for CA-THA. In this nationwide cohort, CA-THA was associated with reduced risks of dislocation, infection, and reoperation, but an increased risk of periprosthetic fracture compared with M-THA. Further research should clarify optimal indications and refine patient selection criteria for CA-THA.
Letter to the Editor. Enhancing safety in anterior sliding decompression osteotomy: concerns and technical considerations. 国際誌

Junya Kusakabe, Ko Hashimoto, Kohei Takahashi, Kenichiro Yahata, Takahiro Onoki, Toshimi Aizawa

Journal of neurosurgery. Spine　1-4　2025年10月3日

DOI： 10.3171/2025.7.SPINE251032 　
Preoperative coronal alignment and tibial implant positioning affect condylar lift‐off in BCS‐TKA

Kento Harada, Masayuki Kamimura, Yu Mori, Takashi Aki, Shunsuke Utsumi, Tomokazu Tanita, Toshiya Uehara, Toshimi Aizawa

Journal of Experimental Orthopaedics　12　(4)　2025年10月
出版者・発行元： Wiley
DOI： 10.1002/jeo2.70609 　

ISSN：2197-1153

eISSN：2197-1153

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Abstract Purpose Condylar lift‐off is the phenomenon in which the femoral component lifts off from the polyethylene insert. In some cases, the mechanical hip–knee–ankle angle (mHKAA) appears more varus than the arithmetic hip–knee–ankle angle (aHKAA) in a standing position, which is thought to be related to lift‐off. This study analyzed factors influencing the difference between postoperative aHKAA and mHKAA in bi‐cruciate‐stabilized total knee arthroplasty (BCS‐TKA). Methods This study included 100 knees that underwent BCS‐TKA. Full‐length standing radiographs of both lower extremities were obtained preoperatively and 1‐year postoperatively. The mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA), and mHKAA were measured and aHKAA (mMPTA−mLDFA) was calculated. The difference between postoperative aHKAA (post‐aHKAA) and post‐mHKAA was defined as post‐ΔHKAA (post‐mHKAA−post‐aHKAA). Correlations between post‐ΔHKAA and the measured parameters were analyzed, and multivariable linear regression analyses were performed to identify independent predictors of post‐ΔHKAA. Results Post‐ΔHKAA was significantly correlated with preoperative mLDFA (pre‐mLDFA, r = −0.30, p < 0.001), pre‐aHKAA ( r = 0.22, p = 0.02), pre‐mHKAA ( r = 0.21, p = 0.03) and post‐mMPTA ( r = −0.29, p = 0.004). Multivariable linear regression analyses revealed that pre‐mLDFA ( β = −0.20, p = 0.02) and post‐mMPTA ( β = −0.32, p = 0.01) were independently associated with post‐ΔHKAA. These results indicate that performing TKA in cases with severe femoral varus alignment and placing the tibial implant in valgus relative to the original joint surface leads to increased postoperative coronal varus alignment in the standing position. Conclusion In BCS‐type TKA, postoperative condylar lift‐off in standing positions is more likely to occur in cases with severe preoperative femoral varus alignment or with valgus tibial implant placement. Level of Evidence Level Ⅳ.
Nationwide Comparison of Cemented versus Uncemented Hemiarthroplasty for Femoral Neck Fractures in the Elderly: A Propensity Score-Matched Analysis Using Japan’s Diagnosis Procedure Combination Database

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Takehiro Sugaya, Hideki Fukuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

The Journal of Arthroplasty　2025年10月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.arth.2025.10.061 　

ISSN：0883-5403
Thromboembolic risks after knee arthroplasty in patients with severe obesity: A large-scale analysis using Japanese medical claims data.

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2025年9月5日

DOI： 10.1016/j.jos.2025.08.007 　

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BACKGROUND: Obesity is associated with an increased risk of complications after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA), particularly in Western populations. However, the effect of severe obesity (body mass index [BMI] ≥ 35 kg/m2) on postoperative complications in Japanese patients remains unclear. METHODS: We conducted a retrospective cohort study using Japan's Diagnosis Procedure Combination (DPC) database, including patients who underwent TKA or UKA between April 2016 and March 2023. Patients were classified into severely obese (BMI ≥35 kg/m2) and non-severely obese (BMI <35 kg/m2) groups. After 1:1 propensity score matching for age, sex, comorbidities, surgical method, and Charlson Comorbidity Index, postoperative complications were compared using chi-square tests and multivariate logistic regression analyses. RESULTS: A total of 7832 matched pairs were analyzed. The incidence of deep vein thrombosis (odds ratio [OR], 1.16; 95 % confidence interval [CI], 1.03-1.29; p = 0.011) and pulmonary embolism (OR, 1.79; 95 % CI, 1.03-3.10; p = 0.037) was significantly higher in the severely obese group. Simultaneous bilateral surgery was also an independent risk factor for venous thromboembolism (VTE). No significant differences were observed in surgical site infection, length of hospital stay, or transfusion volume between the two groups. CONCLUSIONS: Severe obesity and simultaneous bilateral surgery are independent risk factors for VTE following knee arthroplasty in Japanese patients. These findings highlight the need for careful perioperative management in this high-risk population.
Proposal of a new indicator of hip compensation for spinopelvic-hip mismatch: a retrospective study in Japan. 国際誌

Ryo Fujita, Kohei Takahashi, Ko Hashimoto, Kazuyoshi Baba, Kenichiro Yahata, Takahiro Onoki, Takashi Aki, Keisuke Ishikawa, Toshimi Aizawa

Asian spine journal　2025年8月11日

DOI： 10.31616/asj.2024.0475 　

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STUDY DESIGN: retrospective study. PURPOSE: This study aimed to develop an indicator of the compensatory capacity of hip joints in response to spinopelvic mismatch using standard radiographs. OVERVIEW OF LITERATURE: EOS imaging has enabled detailed analysis of hip and lower extremity compensation in sagittal malalignment. However, its high cost and limited availability hinder widespread clinical use. Currently, there are no established indicators to assess hip compensation for spinopelvic mismatch using standard radiographs. METHODS: A total of 209 patients with osteoporosis and 54 with adult spinal deformities were included. Patients were divided into two groups based on pelvic incidence-lumbar lordosis (PI-LL): <20° and ≥20° groups. The sagittal vertical axis (SVA), thoracic kyphosis, PI, pelvic tilt (PT), LL, sacral slope, and pelvic femoral angle (PFA) were measured. Health-related quality of life (HRQOL) was assessed in 86 patients using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ). A new index, PFA-(PI-LL), was defined as spinopelvic-hip mismatch. Correlation coefficients were calculated for each radiographic parameter, and the coefficient of determination (R2) for the relationship of each parameter with SVA was evaluated in both groups. The correlations between SVA, PT, PI-LL, PFA-(PI-LL), and JOABPEQ domain scores were also analyzed. RESULTS: PI-LL correlated with PFA in the PI-LL <20° group (r=0.56, p<0.001) but not in the PI-LL ≥20° group. Among all parameters, PFA-(PI-LL) demonstrated the strongest association with SVA, indicating its superior ability to explain variations in sagittal alignment in both groups and across all patients (all patients, R2=0.77). Significant correlations were observed between the radiographic parameters and JOABPEQ scores across all domains. CONCLUSIONS: PFA-(PI-LL), which represented spinopelvic-hip mismatch, was a reliable indicator of hip compensatory function in terms of anterior trunk inclination and HRQOL.
Skip metastasis of intradural Ewing's sarcoma in the lumbar spine: illustrative case. 国際誌

Junya Kusakabe, Ko Hashimoto, Takahiro Onoki, Kohei Takahashi, Kenichiro Yahata, Tomonori Kawaharada, Toshimi Aizawa

Journal of neurosurgery. Case lessons　10　(5)　2025年8月4日

DOI： 10.3171/CASE25361 　

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BACKGROUND: Ewing's sarcoma in the intradural and extramedullary space is exceedingly rare. Here, the authors report a rare case of skip metastasis of intradural extramedullary Ewing's sarcoma in the lumbar spine. OBSERVATIONS: A 73-year-old man underwent surgery at another hospital for an intradural extramedullary spinal tumor at the L4 level, initially suspected to be a schwannoma. However, postoperative histopathological examination revealed Ewing's sarcoma; subsequently, he received local radiotherapy and chemotherapy. Thirty-eight months postoperatively, the patient developed severe low back pain and bilateral leg pain, accompanied by urinary retention and bowel dysfunction. MRI showed a new intradural extramedullary tumor at the L1 level. Gross-total resection was performed, and histopathological examination confirmed Ewing's sarcoma. Four months after the second surgery, MRI of the lumbar spine revealed tumor recurrence. The patient remained asymptomatic and was treated with additional radiotherapy and chemotherapy, resulting in significant tumor size reduction. LESSONS: This case highlights the aggressive nature of intradural extramedullary Ewing's sarcoma and its propensity for early recurrence and metastasis. Although this presentation is extremely rare, postoperative adjuvant radiotherapy and chemotherapy, including craniospinal irradiation, should be considered to reduce recurrence risk. Frequent follow-up imaging is essential for the early detection of metastatic disease. https://thejns.org/doi/10.3171/CASE25361.
Comparison of Cup Position and Perioperative Characteristics in Total Hip Arthroplasty Following Three Types of Pelvic Osteotomy. 国際誌

Ryuichi Kanabuchi, Yu Mori, Kazuyoshi Baba, Hidetatsu Tanaka, Hiroaki Kurishima, Yasuaki Kuriyama, Hideki Fukuchi, Hiroki Kawamata, Toshimi Aizawa

Medicina (Kaunas, Lithuania)　61　(8)　2025年8月2日

DOI： 10.3390/medicina61081407 　

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Background and Objectives: Total hip arthroplasty (THA) following pelvic osteotomy for developmental dysplasia of the hip (DDH) is technically challenging due to altered acetabular morphology. This study aimed to compare radiographic cup position and perioperative characteristics of THA after three common pelvic osteotomies-periacetabular osteotomy (PAO), shelf procedure, and Chiari osteotomy-with primary THA in Crowe type I DDH. Methods: A retrospective review identified 25 hips that underwent conversion THA after pelvic osteotomy (PAO = 12, shelf = 8, Chiari = 5) and 25 primary THAs without prior osteotomy. One-to-one matching was performed based on sex (exact match), age (within 5 years), and BMI (within 2 kg/m2) without the use of propensity scores. Cup inclination, radiographic anteversion, center-edge (CE) angle, and cup height were measured on standardized anteroposterior radiographs (ICC = 0.91). Operative time, estimated blood loss, and use of bulk bone grafts or reinforcement rings were reviewed. One-way ANOVA with Dunnett's post hoc test and chi-square test were used for statistical comparison. Results: Cup inclination, anteversion, and CE angle did not differ significantly among groups. Cup height was significantly greater in the PAO group than in controls (29.0 mm vs. 21.8 mm; p = 0.0075), indicating a more proximal hip center. The Chiari and shelf groups showed upward trends, though not significant. Mean operative time tended to be longer after PAO (123 min vs. 93 min; p = 0.078). Bulk bone grafts and reinforcement rings were more frequently required in the PAO group (17%; p = 0.036 vs. control), and occasionally in Chiari cases, but not in shelf or control groups. Conclusions: THA after PAO is associated with higher cup placement and greater need for reconstructive devices, indicating increased technical complexity. In contrast, shelf and Chiari conversions more closely resemble primary THA. Preoperative planning should consider hip center translation and bone-stock restoration in post-osteotomy THA.
大腿骨転子部骨折の骨折型はHidden Blood Loss増加のリスク因子となるか?

金谷淳平, 馬場一慈, 相澤利武, 笹島功一, 伊勢福修司, 森優, 田中秀達, 金淵龍一, 相澤俊峰

東日本整形災害外科学会雑誌　37　(3)　209-209　2025年8月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
術前骨粗鬆症治療が人工股関節全置換の術後成績に与える影響

金淵龍一, 森優, 馬場一慈, 田中秀達, 栗山恭明, 畠山拡, 川又裕輝, 福地英輝, 相澤俊峰

東日本整形災害外科学会雑誌　37　(3)　288-288　2025年8月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
Japanese 2021 nationwide survey on complications from spine surgery. 国際誌

Sadayuki Ito, Shiro Imagama, Hiroaki Nakashima, Masaaki Machino, Toshinori Sakai, Toshimi Aizawa, Hideyuki Arima, Hideaki Hamanaka, Yuyu Ishimoto, Satoshi Kato, Yoshiharu Kawaguchi, Hiroaki Konishi, Naohisa Miyakoshi, Hideki Murakami, Yukitaka Nagamoto, Kazuo Nakanishi, Kotaro Nishida, Tetsuro Ohba, Shinya Okuda, Koji Otani, Kota Suda, Nobuyuki Suzuki, Eiji Takasawa, Hidetomi Terai, Fumitake Tezuka, Yu Yamato, Yasutsugu Yukawa, Tokumi Kanemura, Masashi Takaso, Hiroshi Takahashi

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　34　(8)　3095-3105　2025年8月

DOI： 10.1007/s00586-025-08981-z 　

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PURPOSE: To provide an updated analysis of perioperative complications, patient demographics, and surgical techniques in spinal surgeries across Japan and examine their impact on risk management. METHODS: Data were collected prospectively from 739 of 1,106 registered facilities across Japan using the JSSR database. All spinal surgeries conducted in November 2021 were included, capturing complications within 1 month post-surgery. Data analyzed included patient demographics, disease classification, surgical techniques, site, approach, and complications. Descriptive statistics determined complication rates and trends. RESULTS: The survey included 11,559 surgeries (average patient age: 67.0 years). Degenerative diseases comprised 71.0% of cases. Posterior surgical approaches were predominant (87.9%), and minimally invasive techniques were widely adopted. The overall complication rate was 8.8%, with dural tears (2.4%) being the most common. Minimally invasive techniques improved outcomes but posed technical challenges, highlighting the need for advanced training and equipment. CONCLUSION: Japan's aging surgical population and the adoption of minimally invasive techniques are evident. While complication rates remain stable, specific complications such as dural tears require targeted management. These findings underscore tailored surgical strategies for older patients and innovation in techniques, providing critical evidence for improving outcomes and informing healthcare policy in Japan.
Three-dimensional motion analysis of upright bipedal walking android model. 国際誌

Kouji Sanaka, Yusuke Sekiguchi, Daisuke Kurosawa, Seiichi Sugimura, Ko Hashimoto, Kohei Takahashi, Satoru Ebihara, Eiichi Murakami, Toshimi Aizawa

Clinical biomechanics (Bristol, Avon)　129　106620-106620　2025年7月28日

DOI： 10.1016/j.clinbiomech.2025.106620 　

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BACKGROUND: We previously developed a bipedal android model driven by trunk motion via psoas major contractions. A mechanically stabilized principle model was created to preserve gait mechanics, enabling autonomous bipedal walking and reliable center of pressure measurement by addressing knee and foot-ankle joint instability. This study investigated whether the center of pressure trajectory generated by the trunk-driven model approximates that of humans using a three-dimensional gait analysis system. METHODS: Thirty-five markers were attached to healthy subjects versus 24 markers to the principle model. Ground reaction force data were captured at 1200 Hz and analyzed using motion analysis and numerical software. The center of pressure trajectory of the right foot during the stance phase was compared between the principle model and healthy subjects. FINDINGS: Center of pressure trajectories were generally similar during the double-limb stance and single-limb support phases. The principle model showed differences such as a backward deviation of the center of pressure in the direction opposite to walking progression during the single-limb support phase, especially between 47.5 % and 61.5 % of the phase. The trajectory did not extend toward the forefoot, likely due to the shorter stride length, slower walking speed, and prolonged single-limb support duration (0.91 ± 0.05 s vs. 0.41 ± 0.05 s in healthy subjects). INTERPRETATION: Conventional gait analysis assumes passive trunk motion following lower-limb activity. In contrast, the principle model demonstrates trunk-driven motion with passive leg swing, partially replicating human center of pressure trajectories. This suggests a trunk-driven approach may offer insights for gait analysis.
Resection of C2 chordoma after failed ion-beam radiotherapy: illustrative case. 国際誌

Takahiro Onoki, Ko Hashimoto, Kohei Takahashi, Ken-Ichiro Yahata, Junya Kusakabe, Tomonori Kawaharada, Haruo Kanno, Toshimi Aizawa

Journal of neurosurgery. Case lessons　10　(4)　2025年7月28日

DOI： 10.3171/CASE25241 　

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BACKGROUND: Chordomas of the upper cervical spine are rare. Recently, a relatively good long-term prognosis was reported for ion-beam radiotherapy. However, in a few cases, the tumor showed regrowth after radiotherapy. Resection is the treatment of choice in such cases, and spine surgery following ion-beam radiotherapy is associated with multiple complications. Here, the authors present a unique case of a C2 chordoma that showed regrowth after ion-beam radiotherapy. OBSERVATIONS: A 49-year-old man was diagnosed with a C2 chordoma and treated with ion-beam radiotherapy and posterior occipitocervical fusion. Five years later, the tumor showed regrowth, and complete macroscopic resection was successfully performed through mandibular splitting and the transoral approach under O-arm navigation assistance. However, wound healing of the posterior pharyngeal wall was unfavorable, and plastic surgeons created an osteocutaneous radial forearm free flap. Four years after surgery, no obvious local recurrence was observed. LESSONS: This case highlights a unique scenario in which chordoma regrowth occurs after ion-beam radiotherapy. An anterior approach and complete tumor removal may result in a good outcome, but the surgical incision close to the irradiated field may fail to fuse. Therefore, spine surgeons and plastic surgeons should closely coordinate for proper wound closure in patients after ion-beam radiotherapy. https://thejns.org/doi/10.3171/CASE25241.
Impact of ongoing glucocorticoid use on postoperative complications following Total knee arthroplasty: a Japanese Nationwide propensity score-matched cohort study. 国際誌

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Ryuichi Kanabuchi, Hiroshi Hatakeyama, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Modern rheumatology　2025年7月20日

DOI： 10.1093/mr/roaf067 　

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BACKGROUND: Glucocorticoid use poses perioperative concerns in orthopaedic surgery, but its impact on postoperative outcomes following total knee arthroplasty (TKA) remains unclear. METHODS: This retrospective cohort study utilized the Japanese Diagnosis Procedure Combination (DPC) database to examine postoperative complications in patients undergoing TKA between April 2016 and March 2023. Patients receiving continuous glucocorticoid therapy (≥5 mg/day prednisolone equivalent) were identified and matched 1:1 with non-glucocorticoid users using propensity score matching based on age, sex, body mass index, anaesthesia type, simultaneous bilateral surgery, and Charlson Comorbidity Index. Postoperative complications, including pneumonia, surgical site infection, venous thromboembolism, cerebrovascular events, and in-hospital mortality, were compared. RESULTS: A total of 12 212 patients (6 106 per group) were analysed after matching. The glucocorticoid group showed significantly higher incidences of pneumonia (OR: 3.70, 95% CI: 1.89-7.26, p = 0.0001) and in-hospital mortality (OR: 3.59, 95% CI: 1.47-8.73, p = 0.005). No significant differences were observed in the incidence of deep vein thrombosis, pulmonary embolism, or surgical site infection, possibly due to short in-hospital observation and widespread use of prophylactic protocols. Male sex also emerged as an independent risk factor for mortality. CONCLUSIONS: Ongoing glucocorticoid use is associated with an increased risk of postoperative pneumonia and in-hospital mortality following TKA. These findings highlight the need for careful perioperative management in this high-risk population. Further prospective studies are warranted to assess long-term outcomes and clarify the effects of glucocorticoid dosage and duration.
Response to the letter regarding "Increased complications of proximal femur fractures during the COVID-19 pandemic".

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Journal of bone and mineral metabolism　2025年7月18日

DOI： 10.1007/s00774-025-01628-5 　
Increased Risks of Surgical Site Infection and In-Hospital Mortality Following Knee Arthroplasty in Dialysis Patients: Insights From a Japanese Nationwide Cohort. 国際誌

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Tomoki Koyama, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

The Journal of arthroplasty　2025年7月12日

DOI： 10.1016/j.arth.2025.07.010 　

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BACKGROUND: Dialysis patients often develop advanced knee osteoarthritis, necessitating knee arthroplasty. Although total knee arthroplasty is commonly performed, limited data exist on perioperative complications among Japanese dialysis patients. This study uses a Japanese nationwide medical claims database to investigate the incidence of perioperative complications and mortality in dialysis versus nondialysis patients undergoing knee arthroplasty. METHODS: A retrospective analysis was conducted using data from a Japanese nationwide database (April 2016 to March 2023). Propensity score matching was used to balance confounding variables, including age, sex, body mass index, surgical procedures, and comorbidities. A 1:1 propensity score-matched cohort of 1,923 dialysis and 1,923 nondialysis patients was analyzed. Outcomes included in-hospital mortality, surgical site infections, and other complications. Multivariate logistic regression identified risk factors. RESULTS: Dialysis patients exhibited significantly higher in-hospital mortality and surgical site infection risks. The odds ratio (OR) for surgical site infection in dialysis patients was 2.17 (95% confidence interval: 1.31 to 3.61). The dialysis group demonstrated a significantly higher in-hospital mortality risk compared to the nondialysis group (P < 0.0001). No in-hospital deaths were observed among nondialysis patients postmatching, precluding the calculation of an OR. Bilateral simultaneous surgery emerged as an additional independent risk factor, with an OR of 9.94 (95% confidence interval: 1.95 to 50.74) in dialysis patients. CONCLUSIONS: This propensity score-matched study highlights significantly elevated surgical site infection and in-hospital mortality risks for dialysis patients undergoing knee arthroplasty. These findings underscore the necessity for careful perioperative management and the avoidance of high-risk procedures, such as bilateral simultaneous surgeries, in dialysis patients.
High risk of postoperative complications in dialysis patients undergoing total hip arthroplasty: a database study of Japanese nationwide medical claims. 国際誌

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kazuyoshi Baba, Hideki Fukuchi, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Scientific reports　15　(1)　24211-24211　2025年7月7日

DOI： 10.1038/s41598-025-02829-8 　

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Dialysis patients who develop degenerative hip disease or femoral neck fractures may require total hip arthroplasty, and their comorbidities predispose them to complications. This study aimed to evaluate whether dialysis was associated with early postoperative complications using a large database of Japanese. In this cohort study, using the Japanese National Administrative Diagnosis Procedure Combination database on THA for patients on hemodialysis or not from December 2011 to March 2023, we assessed the surgical-related complications, medical complications, and mortality during hospitalization after propensity score matching by age, sex, BMI, and comorbidities. A total of 2,111 pairs of patients on hemodialysis and non-dialysis were included. In THA for patients on hemodialysis, the significant odds ratios for various complications were as follows: dislocation (2.616, 95% CI: 1.282 to 5.338, p < 0.01), reoperation (2.104, 95% CI: 1.222 to 3.623, p < 0.01), deep vein thrombosis (0.407, 95% CI: 0.286 to 0.579, p < 0.01), cerebrovascular events (4.426, 95% CI: 1.495 to 13.10, p < 0.01). These findings help identify postoperative THA risks for patients on dialysis, suggesting that more attention should be paid to preoperative planning and postoperative care.
Postoperative risks of type 2 diabetes in elderly hip fracture patients: a propensity score-matched study.

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Journal of bone and mineral metabolism　2025年7月1日

DOI： 10.1007/s00774-025-01624-9 　

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INTRODUCTION: Type 2 diabetes is associated with an increased risk of fragility fractures, even in individuals with normal or high bone mineral density. However, the impact of type 2 diabetes on postoperative outcomes after hip fracture surgery in elderly Japanese patients remains unclear. This study evaluated the association between type 2 diabetes and postoperative complications, including in-hospital mortality, using a nationwide database in Japan. MATERIALS AND METHODS: A retrospective cohort study was conducted using the Diagnosis Procedure Combination (DPC) database from April 2016 to March 2022. Patients aged ≥ 65 years who underwent hip fracture surgery were included. Propensity score matching (1:1) was performed to adjust for confounders. Logistic regression analyses were used to assess associations between type 2 diabetes and outcomes. RESULTS: Of the 474,293 eligible patients included in this study, 18.5% were identified as having comorbid type 2 diabetes. Following 1:1 propensity score matching, the final analytic cohorts each comprised 83,283 patients. Although statistically significant, the presence of type 2 diabetes was associated with only modest increases in the risks of postoperative myocardial infarction (risk difference [RD]: 0.0007), cognitive dysfunction (RD: 0.0029), and in-hospital mortality (RD: 0.0045), with all comparisons yielding p-values of less than 0.0001. Additionally, the length of hospital stay was longer among patients with type 2 diabetes. CONCLUSIONS: Although the absolute risk differences were small, type 2 diabetes remains an independent risk factor for adverse postoperative outcomes following hip fracture surgery in elderly Japanese patients. Tailored perioperative strategies may help optimize outcomes in this vulnerable population.
Spontaneous Dural Tear Caused by Grade-I Isthmus Spondylolisthesis: A Case Report. 国際誌

Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Yoshito Onoda, Kenichiro Yahata, Ryo Fujita, Keisuke Ishikawa, Junya Kusakabe, Mishio Chiba, Toshimi Aizawa

JBJS case connector　15　(3)　2025年7月1日

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CASE: A 47-year-old woman presented with severe left-sided sciatica and urinary retention. Computed tomography myelography revealed spondylolysis of the second lumbar vertebra with cerebrospinal fluid leakage. The patient underwent surgery; the 2 cauda equina filaments that had prolapsed from the dural tube were repositioned, along with the repair of the dura mater, followed by instrumented lumbar fusion. Postoperatively, the patient's leg pain was completely relieved; however, her urinary retention persisted. CONCLUSION: Computed tomography myelography is important for the early diagnosis and detailed preoperative assessment of spontaneous dural tears, which are caused by osteophytes that form in areas of spondylosis.
Nationwide analysis of spinal surgery in Japan from 1994 to 2021. 国際誌

Sadayuki Ito, Shiro Imagama, Hiroaki Nakashima, Masaaki Machino, Toshinori Sakai, Toshimi Aizawa, Hideyuki Arima, Hideaki Hamanaka, Yuyu Ishimoto, Satoshi Kato, Yoshiharu Kawaguchi, Hiroaki Konishi, Naohisa Miyakoshi, Hideki Murakami, Yukitaka Nagamoto, Kazuo Nakanishi, Kotaro Nishida, Tetsuro Ohba, Shinya Okuda, Koji Otani, Kota Suda, Nobuyuki Suzuki, Eiji Takasawa, Hidetomi Terai, Fumitake Tezuka, Yu Yamato, Yasutsugu Yukawa, Tokumi Kanemura, Masashi Takaso, Hiroshi Takahashi

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　2025年6月13日

DOI： 10.1007/s00586-025-08999-3 　

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PURPOSE: In this study, we aimed to compare the latest 2021 survey data with findings from 1994, 2001, and 2011 to elucidate the trends and transformations in spinal surgery over the past quarter-century. METHODS: Data from the 2021 survey were compared with retrospective data from previous surveys. The 2021 survey collected data on patient demographics, surgical techniques, and perioperative complications of spinal surgeries performed in November 2021 from 739 facilities. Trends in patient age, disease type, surgical approach, and complication rates were analyzed over time. RESULTS: The most common age group shifted from 40 to 59 years in 1994 to the 70s by 2011 and 2021. Degenerative diseases, particularly lumbar spinal stenosis, remain prevalent with an increase in trauma and osteoporotic fractures. Surgical techniques have evolved with a decline in anterior approaches and an increase in minimally invasive and posterior surgeries. Complication rates remained stable, ranging from 8.6 to 10.4%, with a slight increase by 2021 (8.8%). However, dural tears have become more common, likely because of the technical demands of minimally invasive and instrumented surgeries. CONCLUSIONS: The aging population of Japan has influenced spinal surgery demographics, and minimally invasive techniques have become more common, underscoring the need for enhanced training, improved techniques, and strategies tailored to older patients to improve future spinal surgery outcomes and support policy development.
Increased risk of deep vein thrombosis and surgical site infection in cemented total knee arthroplasty: A nationwide propensity score-matched study in Japan. 国際誌

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Kento Harada, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Archives of orthopaedic and trauma surgery　145　(1)　327-327　2025年6月2日

DOI： 10.1007/s00402-025-05943-4 　

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INTRODUCTION: Total knee arthroplasty (TKA) is a widely used treatment for advanced knee osteoarthritis. While cemented fixation is the standard technique, cementless fixation has demonstrated comparable long-term outcomes. However, the association between cement use and postoperative complications, including venous thromboembolism and surgical site infections, remains unclear, particularly in Japanese patients. This study aimed to investigate the incidence of postoperative complications in cemented and cementless TKA using a nationwide database. METHODS: A nationwide cohort study was conducted using Japan's DPC database from April 2016 to March 2023. Patients who underwent TKA were identified, and postoperative complications, including deep vein thrombosis, pulmonary embolism, pneumonia, cerebrovascular events, postoperative cognitive dysfunction, and surgical site infection, were analyzed. One-to-one propensity score (PS) matching was performed based on age, sex, body mass index, type of anesthesia, simultaneous bilateral surgery, Charlson comorbidity index, and comorbidities to ensure comparability. Statistical analyses included χ² tests, Student's t-tests, and multivariate logistic regression analysis. RESULTS: A total of 228,595 patients met the eligibility criteria, with 21,906 matched pairs in the cemented and cementless groups after PS matching. The incidence of deep vein thrombosis (OR: 1.231, 95% CI: 1.151-1.316, p < 0.0001) and surgical site infection (OR: 1.716, 95% CI: 1.420-2.073, p < 0.0001) was significantly higher in the cemented group. No significant differences were observed in pulmonary embolism or other complications. CONCLUSION: Cement application was associated with an increased risk of deep vein thrombosis and surgical site infection. These findings suggest that careful perioperative management may be warranted in patients undergoing cemented TKA.
Case Report: Xanthogranulomatous Osteomyelitis of the Femur: A Rare Mimic of Malignant Bone Tumors. 国際誌

Hiroshi Hatakeyama, Yu Mori, Shinichirou Yoshida, Jun Iwatsu, Hirotaka Kurata, Shin Hitachi, Mika Watanabe, Toshimi Aizawa

International journal of rheumatic diseases　28　(6)　e70313　2025年6月

DOI： 10.1111/1756-185X.70313 　
Postoperative paralysis following the surgery for thoracic ossification of the posterior longitudinal ligament: perioperative and intraoperative management strategies. Illustrative case. 国際誌

Kohei Takahashi, Ko Hashimoto, Kenichiro Yahata, Takahiro Onoki, Junya Kusakabe, Tomonori Kawaharada, Toshimi Aizawa

Journal of neurosurgery. Case lessons　9　(20)　2025年5月19日

DOI： 10.3171/CASE25195 　

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BACKGROUND: The treatment of thoracic ossification of the posterior longitudinal ligament (OPLL) remains a significant challenge, with a postoperative paralysis rate exceeding 30%. The underlying mechanisms of postoperative paralysis are still unclear, necessitating further investigation into potential risk factors and preventive strategies. OBSERVATIONS: The authors report the case of a 42-year-old male with diabetes and hypertension who developed complete lower limb paralysis after surgery for thoracic myelopathy due to OPLL. Intraoperative monitoring showed absent motor evoked potentials until the posterior longitudinal ligament was severed, after which they became detectable. The surgery lasted more than 13 hours, with mean arterial pressure maintained between 44 and 91 mm Hg. Postoperative MRI revealed extensive spinal cord edema without severe compression. The exact cause of postoperative paralysis in this case remains unclear; however, possible causes include white cord syndrome or spinal cord ischemia. LESSONS: Postoperative paralysis in thoracic OPLL surgery remains poorly understood. Identifying and addressing risk factors for spinal cord ischemia and reperfusion injury are crucial. The authors propose strategies to reduce risk, including prone and supine position tests, the use of an ultrasonic surgical aspirator to prevent heat-induced spinal cord damage, shortening surgical duration, and meticulous blood pressure management. https://thejns.org/doi/10.3171/CASE25195.
Thromboembolic and infectious complication risks in TKA and UKA: evidence from a Japanese nationwide cohort. 国際誌

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Kento Harada, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Knee surgery & related research　37　(1)　19-19　2025年5月8日

DOI： 10.1186/s43019-025-00273-6 　

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INTRODUCTION: Total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) are widely used to treat knee osteoarthritis. TKA significantly contributes to long-term pain relief and joint function improvement, while UKA offers faster recovery and reduced early complications. However, TKA and UKA complication risks, aside from conditions such as deep vein thrombosis, have not been thoroughly investigated. This study compares the in-hospital complication risks of TKA and UKA using a nationwide Japanese database. METHODS: A retrospective cohort study was conducted using data from the Japanese Diagnosis Procedure Combination (DPC) database, spanning from April 2016 to March 2023. A total of 259,319 knee arthroplasty cases (TKA: 228,595; UKA: 30,724) were analyzed. Propensity score matching (1:1) was used to adjust for age, sex, comorbidities, and surgical factors, resulting in 30,591 matched pairs. Multivariable logistic regression analyses assessed the risks of complications, including deep vein thrombosis, pulmonary embolism, and surgical site infections. RESULTS: Deep vein thrombosis is frequently observed as a complication with a high incidence rate. Even after propensity score matching, the incidence remained significantly higher in the TKA group (8.8%) compared with the UKA group (6.1%) (p < 0.0001). TKA was associated with significantly higher risks of deep vein thrombosis (odds ratio (OR): 1.467, 95% confidence interval (CI) 1.380-1.560, p < 0.0001), pulmonary embolism (OR: 1.709, 95% CI 1.182-2.470, p = 0.0044), and surgical site infection (OR: 1.512, 95% CI 1.277-1.790, p < 0.0001) compared with UKA. UKA showed lower risks of cognitive dysfunction, pneumonia, transfusion requirements, and shorter hospital stays. However, patients who underwent UKA had a higher risk of periprosthetic fractures. CONCLUSIONS: This study highlights the distinct risk profiles of TKA and UKA, emphasizing the need for tailored surgical decision-making. UKA offers advantages in reducing complications for specific patient populations. Strengthening prophylactic measures is crucial for effectively managing thromboembolic and infectious complications in patients undergoing TKA.
Biomechanical Comparison of Transverse Capsulotomy Versus Longitudinal Capsulotomy of the Hip: A Cadaveric Study. 国際誌

Hidetatsu Tanaka, Kazuyoshi Baba, Yu Mori, Yasuaki Kuriyama, Ryuichi Kanabuchi, Eiji Itoi, Toshimi Aizawa

Orthopaedic journal of sports medicine　13　(5)　23259671251334145-23259671251334145　2025年5月

DOI： 10.1177/23259671251334145 　

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BACKGROUND: Biomechanical effect on hip joint stability between the transverse interportal capsulotomy and the longitudinal capsulotomy in arthroscopy has not been fully investigated. PURPOSE: To evaluate whether rotational stability and distraction resistance differ between the 2 capsulotomy directions using fresh-frozen cadavers. STUDY DESIGN: Controlled laboratory study. METHODS: Twelve hips of 6 fresh-frozen cadavers, including intact femur and pelvis, were tested in 3 conditions: intact, capsulotomy, and repaired. Two capsulotomy patterns were made: a 4-cm transverse capsular resection based on a transverse interportal capsulotomy, and longitudinal capsulotomy. Six hips were transverse capsulotomy and 6 hips were longitudinal capsulotomy. The pelvis was fixed to a wooden plate, and the intramedullary nail was inserted into the femur. To evaluate rotational stability, internal and external torques of 5 N·m were applied at 15° of hip extension and 0°, 15°, 30°, 45°, and 60° of hip flexion, respectively. To test for distraction, the specimens were axially loaded from 0- to 150-N distraction forces at different flexion angles (0°, 30°, 45°, 60°). RESULTS: The external rotation laxity increased significantly after the transverse capsulotomy at all flexion angles and longitudinal capsulotomy only at 0°. The separation distance increased significantly after the transverse and longitudinal capsulotomies. The change in external rotation laxity was significantly greater in transverse capsulotomy at 15° of hip extension and 0° than longitudinal capsulotomies in unrepaired conditions compared with intact conditions. With distraction loads, the transverse capsulotomy resulted in a significantly greater separation distance than the longitudinal capsulotomy at all flexion angles with 100 N, and at 0° and 60° with 50 N. Significant differences were observed after capsular repaired compared with intact for external rotation angle at 15° extension and 0°, and separation distance at 60° flexion with 150 N and 100 N between capsulotomy directions. CONCLUSION: This cadaveric study demonstrated that the hips with the longitudinal capsulotomy resulted in less external rotation laxity, especially at 15° extension and 0°, and less distraction laxity compared with those with the transverse capsulotomy; and these differences remained after repair of capsulotomy. CLINICAL RELEVANCE: Either capsulotomy direction is effective if the capsular repair is performed properly because the standard capsular repair improves capsular stability. However, surgeons should note that the longitudinal incision tends to be more stable at lower levels of hip flexion.
Effectiveness of Stress Shielding Prevention Using a Low Young's Modulus Ti-33.6Nb-4Sn Stem: A 7-Year Follow-Up Study. 国際誌

Kazuyoshi Baba, Yu Mori, Hidetatsu Tanaka, Ryuichi Kanabuchi, Yasuaki Kuriyama, Hiroaki Kurishima, Kentaro Ito, Masayuki Kamimura, Daisuke Chiba, Toshimi Aizawa

Medical sciences (Basel, Switzerland)　13　(2)　2025年5月1日

DOI： 10.3390/medsci13020051 　

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BACKGROUND: Stress shielding (SS) after total hip arthroplasty (THA) leads to proximal femoral bone loss and increases the risk of complications such as implant loosening and periprosthetic fracture. While various low-stiffness stems have been developed to prevent SS, they often compromise mechanical stability. A novel femoral stem composed of Ti-33.6Nb-4Sn (TNS) alloy offers a gradually decreasing Young's modulus from proximal to distal regions, potentially improving load distribution and reducing SS. This study aimed to evaluate the mid-term clinical and radiographic outcomes of the TNS stem, with a particular focus on its effectiveness in suppressing SS. METHODS: A prospective clinical study was conducted involving 35 patients who underwent THA using the TNS stem, with a minimum follow-up of 7 years. Twenty-one patients with Ti6Al4V metaphyseal-filling stems served as controls. Clinical outcomes were assessed using Japanese Orthopaedic Association (JOA) scores, and radiographic SS was graded using Engh's classification and analyzed in Gruen zones. Inter-examiner reliability and statistical comparisons between groups were performed using appropriate tests. RESULTS: The TNS group showed significantly higher preoperative JOA scores than the control group, but no significant difference in final scores. Both groups demonstrated significant improvement postoperatively. Third-degree SS occurred in the TNS group, although the overall SS grade distribution was significantly lower than in the control group (p = 0.03). SS frequency was significantly reduced in Gruen Zones 2, 3, and 6 in the TNS group. CONCLUSIONS: The TNS stem demonstrated a significant reduction in SS progression compared to conventional titanium stems over a 7-year period, with comparable clinical outcomes. However, the occurrence of third-degree SS indicates that material optimization alone may be insufficient, highlighting the need for further design improvements.
Comparison of outcomes and cost-effectiveness of simultaneous and staged total hip arthroplasty using the anterolateral-supine approach. 国際誌

Hiroaki Kurishima, Norikazu Yamada, Atsushi Noro, Hidetatsu Tanaka, Yu Mori, Toshimi Aizawa

Journal of orthopaedic surgery and research　20　(1)　424-424　2025年4月29日

DOI： 10.1186/s13018-025-05840-x 　

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BACKGROUND: To date, no study has compared simultaneous bilateral total hip arthroplasty (simBTHA) with staged BTHA (stgBTHA) using the anterolateral-supine approach (ALSA). This study compared the outcomes and cost-effectiveness of simBTHA and stgBTHA using ALSA. METHODS: This retrospective cohort study was conducted on patients who required bilateral ALSA THA at the time of their initial medical evaluation between August 2015 and January 2023. Patients were divided into two groups: simBTHA and stgBTHA. Demographic data, including age, sex, body mass index (BMI), and American Society of Anesthesiologists Physical Status (ASA-PS) scores, were collected. Operative outcomes such as surgical time, blood loss, autologous and allogeneic blood transfusions, and time to ambulation were compared. Clinical outcomes were assessed using the Japanese Orthopaedic Association (JOA) hip score, Japanese Orthopaedic Association Hip-disease Evaluation Questionnaire (JHEQ), and Forgotten Joint score-12 (FJS-12). Postoperative complications, revisions, readmissions, and mortality within 90 days were also recorded. The total cost, length of stay (LOS), and time interval between surgeries in the stgBTHA group were analyzed. RESULTS: A total of 129 patients were included: 104 in the simBTHA group and 25 in the stgBTHA group. The preoperative ASA-PS significantly differed between the two groups (P < 0.01), but other demographic data were not significantly different. The simBTHA group had significantly shorter surgical times (156 min) compared to the stgBTHA group (175 min) (p = 0.02). Blood loss was similar between the two groups (670 mL for simBTHA and 629 mL for stgBTHA). There were no significant differences in the time to ambulation, postoperative complications, or clinical outcomes between the two groups. However, the simBTHA group had a significantly lower total cost (83.2%, p < 0.01) and shorter LOS (20.5 days) compared to the stgBTHA group (30 days) (p < 0.01). No significant differences in complication rates, revisions, or readmissions were observed between the groups. CONCLUSIONS: SimBTHA with ALSA provides comparable clinical outcomes to stgBTHA while offering significant advantages in terms of reduced costs and shorter hospital stays. For patients with suitable health conditions, simBTHA is a preferable choice due to its faster recovery and greater cost-effectiveness.
Limited effect of preoperative dental clearance on infection prevention in primary or revision hip arthroplasty for high- and low-risk groups

Kazuyoshi Baba, Hidetatsu Tanaka, Ryuichi Kanabuchi, Yasuaki Kuriyama, Daisuke Chiba, Yu Mori, Toshimi Aizawa

Journal of Orthopaedic Reports　2025年4月

DOI： 10.1016/j.jorep.2025.100565 　
A novel, easy-to-use scoring system for the diagnosis of extraforaminal stenosis of lumbosacral transition using X-ray and CT scan.

Kohei Takahashi, Myo Min Latt, Takumi Tsubakino, Manabu Suzuki, Takeshi Nakamura, Takeshi Hoshikawa, Tomowaki Nakagawa, Ko Hashimoto, Takahiro Onoki, Toshimi Aizawa, Yasuhisa Tanaka

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2025年3月24日

DOI： 10.1016/j.jos.2025.03.001 　

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BACKGROUND: The diagnosis of extraforaminal stenosis of the lumbosacral transition (ESLT) using conventional two-dimensional (2D) magnetic resonance imaging (MRI) (2D-MRI) is challenging, with some overlooking of ESLT. It is desirable to have criteria for determining whether patients require additional three-dimensional MRI (3D-MRI). In this study, we created a simple scoring system to screen for ESLT using X-rays and computed tomography (CT). METHODS: Ninety-two cases with unilateral L5 radiculopathy were recruited. We used 3D-MRI to determine the presence of ESLT. X-rays and CT were assessed by two examiners. X-rays were assessed for "vertebral inclination", "lumbosacral overlap sign", "lordosis angle", "disc height", and "vacuum phenomenon". Axial CT slices were assessed for "transverse process drooping," "nearthrosis" between transverse process and sacral ala, "osteosclerosis" of L5 endplate, and "osteophyte". Correlation between ESLT and each radiological variable was assessed. Reproducible variables were defined as >0.6 for both intra- and interobserver agreement. Multivariate logistic regression analysis was performed using the radiological variables that were correlated with ESLT and judged to be reproducible. Finally, a score was assigned to each selected variable considering the odds ratio (OR), and a radiological index for screening the extraforaminal stenosis (RISE) score was established. The receiver operating characteristic (ROC) curve analysis was performed for external validation. RESULTS: Vertebral inclination (>3°) (OR: 4.8, p = 0.003), nearthrosis (OR: 10.2, p < 0.001), and osteophyte (OR: 5.2, p = 0.002) were selected. Considering the OR, 1 point was assigned to vertebral inclination and osteophyte, and 2 points were assigned to nearthrosis, obtaining RISE score (0-4 points). The area under the ROC curve was 0.91. CONCLUSIONS: The RISE score accurately predicted the presence of ESLT, allowing aids in the selection of cases that require 3D-MRI.
腰椎変性すべり症に対する全内視鏡下腰椎椎体間固定術術後3年の治療成績と課題の検討

山屋誠司, 橋本功, 古泉豊, 矢部裕, 須田英明, 小城繁明, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本整形外科学会雑誌　99　(2)　S406-S406　2025年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
不眠と肩こりの関連東日本大震災被災地における3年の縦断調査

矢部裕, 辻一郎, 菅原由美, 相澤俊峰

日本整形外科学会雑誌　99　(3)　S695-S695　2025年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
腰部脊柱管狭窄症に対するUBE/BESS複数ポータル式灌流型脊椎内視鏡手術 CUSUM法を用いたラーニングカーブの検討

山屋誠司, 吉水隆貴, 佐々木寛二, 橋本功, 古泉豊, 矢部裕, 須田英明, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本整形外科学会雑誌　99　(3)　S1157-S1157　2025年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
全国DPCデータベース分析による関節リウマチ併存高齢患者の大腿骨近位部骨折術後合併症リスクの検討

金淵龍一, 森優, 馬場一慈, 田中秀達, 栗山恭明, 畠山拡, 千葉美詩央, 相澤俊峰

日本整形外科学会雑誌　99　(3)　S606-S606　2025年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
新型コロナウイルス感染症パンデミックが大腿骨近位部骨折患者の合併症に与える影響日本におけるDPCデータベースからの研究

田中秀達, たら澤邦男, 森優, 伏見清秀, 藤森研司, 相澤俊峰

日本整形外科学会雑誌　99　(3)　S638-S638　2025年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
骨粗鬆症患者における腰痛と脊柱・骨盤・下肢アライメントの相互関係の検討

藤田涼, 高橋康平, 大野木孝嘉, 八幡健一郎, 小野田祥人, 森優, 橋本功, 相澤俊峰

日本整形外科学会雑誌　99　(3)　S745-S745　2025年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
Stage 1大腿骨頭壊死患者の予後に関する検討

田中秀達, 馬場一慈, 金淵龍一, 栗山恭明, 川又裕輝, 福地英輝, 森優, 相澤俊峰

日本整形外科学会雑誌　99　(3)　S1040-S1040　2025年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
The dural deviation ratio: a novel indicator for preoperative differentiation of intradural extension in spinal dumbbell schwannomas using Axial T2-weighted MRI. 国際誌

Rei Kimura, Ko Hashimoto, Kohei Takahashi, Takahiro Onoki, Kenichiro Yahata, Toshimi Aizawa

The spine journal : official journal of the North American Spine Society　2025年2月22日

DOI： 10.1016/j.spinee.2025.02.003 　

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OBJECTIVE: This study investigates the potential of using dural deviation in axial T2-weighted MRI to differentiate between Eden type-2 and type-3 spinal dumbbell schwannomas preoperatively. METHODS: A retrospective analysis of 43 patients with spinal dumbbell Schwannomas was conducted. Tumors were classified into Eden type-2 or type-3 based on the need for dural incision during surgery. The dural deviation ratio (D-ratio) was measured using axial T2-weighted MRI. Statistical significance and diagnostic accuracy were assessed with Mann-Whitney U test and receiver operating characteristic (ROC) analysis. The authors declare no conflicts of interest and no funding sources for this study. RESULTS: The D-ratio was significantly higher in type-2 tumors (median: 0.904) than in type-3 tumors (median: 0.585) (p<.001). ROC analysis showed an AUC of 0.950, with a cut-off value of 0.746, 92.4% sensitivity, and 91.2% specificity. CONCLUSIONS: The D-ratio is a reliable indicator for distinguishing between type-2 and type-3 Schwannomas, with a cut-off value of 0.746.
Preoperative Osteoporosis Treatment Reduces Stress Shielding in Total Hip Arthroplasty

Ryuichi Kanabuchi, Yu Mori, Kazuyoshi Baba, Hidetatsu Tanaka, Yasuaki Kuriyama, Hideki Fukuchi, Hiroki Kawamata, Toshimi Aizawa

Medical Sciences　2025年1月28日

DOI： 10.3390/medsci13010010 　
Does Osteonecrosis of the Femoral Head Increase Early Complication Rates After Total Hip Arthroplasty? A Japanese Nationwide Medical Claims Database Study

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Yasuaki Kuriyama, Hiroki Kawamata, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

The Journal of Arthroplasty　2025年1月23日

DOI： 10.1016/j.arth.2025.01.029 　

ISSN：0883-5403
O-Arm Navigated En Bloc Resection of a Paraspinal Malignant Peripheral Nerve Sheath Tumor Involving the Thoracic Spine: A Case Report

Keisuke Ishikawa, Takahiro Onoki, Ko Hashimoto, Kohei Takahashi, Ken-ichiro Yahata, Junya Kusakabe, Tomonori Kawaharada, Haruo Kanno, Mika Watanabe, Shin Hitachi, Toshimi Aizawa

Spine Surgery and Related Research　2025年
出版者・発行元： Japanese Society for Spine Surgery and Related Research
DOI： 10.22603/ssrr.2025-0201 　

eISSN：2432-261X
A Predictive Formula for Sagittal Vertical Axis in Japanese Women Using Spinopelvic-Hip Mismatch

Kohei Takahashi, Ryo Fujita, Ko Hashimoto, Yu Mori, Kenichiro Yahata, Kazuyoshi Baba, Takahiro Onoki, Keisuke Ishikawa, Junya Kusakabe, Michiyoshi Sato, Takeshi Nakamura, Ryo Sugawara, Kyoichi Handa, Haruo Kanno, Hiroshi Ozawa, Yasuhisa Tanaka, Toshimi Aizawa

Spine Surgery and Related Research　2025年
出版者・発行元： Japanese Society for Spine Surgery and Related Research
DOI： 10.22603/ssrr.2025-0291 　

eISSN：2432-261X
High-accuracy spinal alignment monitoring using the head angle and visual distance in computer users. 国際誌

Ko Hashimoto, Yusuke Sekiguchi, Kaho Matsuda, Masataka Hori, Yutaka Mizuno, Ryosuke Shibuya, Kohei Takahashi, Takahiro Onoki, Kenichiro Yahata, Shin-Ichi Izumi, Toshimi Aizawa

PloS one　20　(6)　e0326431　2025年

DOI： 10.1371/journal.pone.0326431 　

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STUDY DESIGN: A Prospective Validation Study. OBJECTIVES: To validate a novel, noninvasive method for estimating the spinal sagittal alignment during seated computer work, using the head angle (HA) and visual distance (VD) as primary parameters. METHODS: A 3D motion analysis system measured HA and VD in 21 healthy volunteers. The relationship between these parameters and spinal sagittal alignment, as determined by body surface markers, was investigated. To validate this method, radiographic measurements were taken in a separate group of 32 patients to confirm the link between body surface landmarks and actual spinal alignment. Additional variables, including gender, age, height, and weight, were incorporated into the model to improve accuracy. RESULTS: HA and VD showed significant correlations with spinal sagittal alignment, particularly for the cervical spine (C2-C7). Incorporating demographic factors further enhanced the predictive accuracy. Radiological validation confirmed that body surface marker-based measurements are closely aligned with standard radiographic indices widely used in spine surgery. CONCLUSIONS: This study introduces a reliable and practical method for continuously monitoring spinal sagittal alignment in seated computer users. The approach demonstrates high accuracy, particularly for the cervical spine and holds promise for the development of posture-monitoring technologies to help prevent neck and back pain associated with prolonged computer use.
Limited impact of weekend admissions on hip fracture outcomes in elderly patients: A study from a Japanese nationwide medical claims database.

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Geriatrics & gerontology international　2024年12月4日

DOI： 10.1111/ggi.15041 　

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AIM: The effectiveness of early surgery in preventing complications in elderly Japanese hip fracture patients and the impact of weekend hospitalization need further investigation. The purpose of this study was to determine whether weekend hospitalization affects the incidence of various sequelae and death during hospitalization in elderly hip fracture patients using a comprehensive Japanese hip fracture case database. METHODS: We retrospectively analyzed the Japanese National Administrative DPC (Diagnosis Procedure Combination) database from April 2016 to March 2022. During this period, approximately 1100 DPC-affiliated hospitals consistently provided medical records with consent for the study. The study focused on weekend hospitalizations and investigated the associations with postoperative pneumonia, pulmonary embolism, myocardial infarction, urinary tract infection, acute renal dysfunction, dementia, and in-hospital mortality after propensity score matching. Owing to the large population size of the study, significance levels were strictly enforced, and a P-value < 0.001 was considered statistically significant. RESULTS: After performing propensity score matching based on age, sex, and comorbidities, 111 035 patient pairs were identified, comparing those admitted on weekends versus weekdays. The analysis showed no heightened risk of sequelae for those admitted during the weekend compared with weekdays. Additionally, there was a slight trend toward higher mortality risk during weekend hospital stays; however, the increase was insignificant, with a hazard ratio of 1.071 (95% confidence interval: 1.005-1.140, P = 0.03). CONCLUSION: The results of this study indicate that weekend hospitalization for elderly patients with hip fractures is not definitively associated with an increase in various sequelae or in-hospital mortality and that the importance of early surgery for elderly patients with hip fractures may be recognized and promoted in Japan. Geriatr Gerontol Int 2024; ••: ••-••.
Destructive spondyloarthropathy of the lumbar spine in patients on long-term haemodialysis: a computed tomography-based study. 国際誌

Yutaka Yabe, Keisuke Ishikawa, Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　2024年11月26日

DOI： 10.1007/s00586-024-08578-y 　

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PURPOSE: Destructive spondyloarthropathy (DSA) is a serious complication of long-term haemodialysis; it commonly occurs in the cervical spine and has been investigated in cervical lesions. Although DSA of the lumbar spine has been reported, only few studies have investigated this, and the characteristics of patients with lumbar DSA are unclear. The present study aimed to elucidate the prevalence of DSA and its clinical characteristics in patients with DSA in the lumbar spine using computed tomography (CT) images of the patients who underwent lumbar spine surgery. METHODS: Consecutive patients undergoing haemodialysis who underwent lumbar spine surgery (n = 67) were assessed. DSA was diagnosed using CT images, and the patients were divided into non-DSA and DSA groups. The differences in the clinical characteristics of the patients in the two groups were analysed. RESULTS: The prevalence of patients diagnosed with DSA was 31.3%. The mean intra- and inter-observer kappa values of DSA classification using CT images were 0.68 and 0.53, respectively. Although there were no significant differences in the age, sex, body mass index, reason for lumbar surgery, disease causing haemodialysis, age at the start of haemodialysis, or duration of haemodialysis between the non-DSA and DSA groups, the duration of haemodialysis tended to be longer in the DSA group. CONCLUSION: Among patients on haemodialysis who underwent lumbar spine surgery, the prevalence of patients with DSA was 31.3%. Classification of DSA using CT showed moderate-to-substantial agreement. Patients with DSA tended to have a longer haemodialysis duration.
Total Knee Arthroplasty in Patients With Ankle Osteoarthritis Affects Contralateral Ankle Alignment and Postoperative Outcome of Total Knee Arthroplasty. 国際誌

Tomoki Koyama, Yu Mori, Shunsuke Utsumi, Kento Harada, Kentaro Ito, Hidetatsu Tanaka, Takashi Aki, Hideaki Nagamoto, Masayuki Kamimura, Toshimi Aizawa

Foot & ankle international　10711007241283783-10711007241283783　2024年11月6日

DOI： 10.1177/10711007241283783 　

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BACKGROUND: This study investigated the impact of total knee arthroplasty (TKA) on the alignment of the ankle joint, focusing on changes in coronal alignment of both ankles. METHODS: This retrospective study, conducted at our hospital, included 64 patients older than 70 years who underwent TKA for varus knee osteoarthritis (OA). Using full-length standing radiographs of both lower extremities taken preoperatively and 6 months postoperatively, we assessed ankle OA grading based on the Takakura-Tanaka classification and measured mechanical hip-knee-ankle (mHKA) and the tibiotalar angle (TTA) on both the surgical and contralateral side. Additionally, we examined the impact of ankle OA on postoperative clinical scores, the Knee injury and Osteoarthritis Outcome Score, following TKA. RESULTS: Based on the classification, ankle OA stage 2 or higher was present in 13 cases on the surgical side and 13 cases on the contralateral side. On the surgical side, mHKA changed from 12.2 to 1.8 degrees varus (P < .001) and TTA from 1.7 to 1.0 degrees varus (P = .002). On the contralateral side, mHKA changed from 4.0 to 5.4 degrees varus (P = .04), and TTA from 2.7 to 3.0 degrees varus (P < .001). In ankle OA stage 2 or higher patients, contralateral TTA changed from 5.2 to 6.5 degrees varus (P < .001) and unchanged in stage 1 patients. Ankle OA stage 2 or higher patients had worse ADL outcomes than stage 1 patients (score: 67.2 and 78.3, respectively, P = .03). CONCLUSION: This study suggests an apparent interrelationship between knee and ankle OA and the potential negative influence of TKA on ankle OA.
TiNbSn Alloy Plates with Low Young's Modulus Modulates Interfragmentary Movement and Promote Osteosynthesis in Rat Femur

Tomoki Koyama, Yu Mori, Masayuki Kamimura, Hidetatsu Tanaka, Rui Tome, Ketaro Ito, Masashi Koguchi, Naoko Mori, Toshimi Aizawa

Journal of the Mechanical Behavior of Biomedical Materials　106820-106820　2024年11月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.jmbbm.2024.106820 　

ISSN：1751-6161
Impact of Aging and Knee Osteoarthritis on Lower Limb Alignment and CPAK Classification: Gender Differences in a Japanese Cohort

Kento Harada, Yu Mori, Masayuki Kamimura, Takashi Aki, Tomoki Koyama, Toshimi Aizawa

Journal of Clinical Medicine　2024年10月19日

DOI： 10.3390/jcm13206250 　
Validating the Definition of Lumbar Instability-A Cross-Sectional Study with 420 Healthy Volunteers. 国際誌

Manabu Suzuki, Yasuhisa Tanaka, Ko Hashimoto, Takumi Tsubakino, Takeshi Hoshikawa, Kohei Takahashi, Myo Min Latt, Toshimi Aizawa

Journal of clinical medicine　13　(20)　2024年10月14日

DOI： 10.3390/jcm13206116 　

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Background/Objectives: Low back pain is thought to be caused by lumbar instability. To date, multiple definitions of radiological lumbar instability have been used without verifying the "normal range" of the lumbar segmental mobility. Ideally, normative data for lumbar mobility in healthy individuals are required to establish an acceptable threshold for lumbar instability. This study aims to elucidate (i) the prevalence of so-called radiological lumbar instability at each lumbar spine level in conventional criteria and (ii) a practical radiological threshold for lumbar instability in healthy individuals. Methods: Participants completed a questionnaire and underwent standard active dynamic radiography of the lumbar spine in the standing position. Intervertebral range of motion (IROM) and sagittal translation distance (ΔST) were measured at each intervertebral level. Nachemson's criteria of radiological lumbar instability were applied. Results: This study involved four hundred and twenty participants (249 males and 171 females); 76% (320/420) met the criteria for radiological lumbar instability. The definition of lumbar instability based on IROM and ΔST was achieved by 0.2% and 1.7% of participants at the L5-sacrum (L5-S) level, respectively. Conclusions: The normative data of lumbar mobility were obtained from a large number of participants who had less LBP-related ADL disability. The widely accepted criteria for lumbar instability were not applicable except for the L5-S level. Further studies of lumbar mobility, including patients with severe LBP, might prove the relationship between hypermobility of the lumbar spine and LBP.
Modulation of osteoblastogenesis by NRF2: NRF2 activation suppresses osteogenic differentiation and enhances mineralization in human bone marrow-derived mesenchymal stromal cells. 国際誌

Takahiro Onoki, Janos Kanczler, Andrew Rawlings, Melanie Smith, Yang-Hee Kim, Ko Hashimoto, Toshimi Aizawa, Richard O C Oreffo

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　38　(17)　e23892　2024年9月15日

DOI： 10.1096/fj.202400602R 　

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Mesenchymal stromal stem cells (MSCs) or skeletal stem cells (SSCs) play a major role in tissue repair due to their robust ability to differentiate into osteoblasts, chondrocytes, and adipocytes. Complex cell signaling cascades tightly regulate this differentiation. In osteogenic differentiation, Runt-related transcription factor 2 (RUNX2) and ALP activity are essential. Furthermore, during the latter stages of osteogenic differentiation, mineral formation mediated by the osteoblast occurs with the secretion of a collagenous extracellular matrix and calcium deposition. Activation of nuclear factor erythroid 2-related factor 2 (NRF2), an important transcription factor against oxidative stress, inhibits osteogenic differentiation and mineralization via modulation of RUNX2 function; however, the exact role of NRF2 in osteoblastogenesis remains unclear. Here, we demonstrate that NRF2 activation in human bone marrow-derived stromal cells (HBMSCs) suppressed osteogenic differentiation. NRF2 activation increased the expression of STRO-1 and KITLG (stem cell markers), indicating NRF2 protects HBMSCs stemness against osteogenic differentiation. In contrast, NRF2 activation enhanced mineralization, which is typically linked to osteogenic differentiation. We determined that these divergent results were due in part to the modulation of cellular calcium flux genes by NRF2 activation. The current findings demonstrate a dual role for NRF2 as a HBMSC maintenance factor as well as a central factor in mineralization, with implications therein for elucidation of bone formation and cellular Ca2+ kinetics, dystrophic calcification and, potentially, application in the modulation of bone formation.
Rheumatoid arthritis increases complication risks in elderly hip fracture patients.: A Japanese nationwide medical claims database study. 国際誌

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Ryuichi Kanabuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Modern rheumatology　2024年9月5日

DOI： 10.1093/mr/roae088 　

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OBJECTIVES: Rheumatoid arthritis (RA) is a common autoimmune disorder characterized by chronic inflammation and periarticular bone loss, leading to systemic osteoporosis and heightened fracture susceptibility, especially hip fractures among the elderly. This study aimed to evaluate the outcomes and complications associated with hip fractures in patients with RA relative to those without RA. METHODS: Using the Japanese National Administrative Diagnosis Procedure Combination (DPC) database, we examined cases of femoral neck fractures from April 2016 to March 2023. After one to three propensity score matching for age, sex, and complications, we examined the association between RA, complications, and mortality during hospitalization in elderly patients with hip fractures. RESULTS: The findings revealed that elderly Japanese RA patients with hip fractures had significantly higher complications of pneumonia than elderly hip fracture patients without RA, with a ratio of 1.232 (95% CI: 1.065-1.426, p=0.0056), and pulmonary embolism, with a ratio of 1.155 (95% CI: 1.036-1.287, p=0.009) in multivariate logistic regression analyses. Although not significantly elevated, it also found a trend toward higher mortality during hospitalization, with a ratio of 1.179 (95% CI: 0.973-1.429, p=0.096). CONCLUSIONS: A substantial study based on the Japanese DPC database revealed a significant association between RA and increased complications, including pneumonia and pulmonary embolism. On the other hand, there was a nonsignificant but higher trend for risk of mortality during hospitalization for hip fracture in elderly RA patients. Implementing preventive strategies is essential to minimizing complications in the treatment of hip fractures in patients with RA.
低弾性率チタン(TiNbSn)合金製ロッキングプレートはラット大腿骨骨切り部の骨癒合を促進する

古山和樹, 森優, 上村雅之, 田中秀達, 伊東健太郎, 古口昌志, 原田健登, 内海峻輔, 畠山拡, 正橋直哉, 相澤俊峰

日本整形外科学会雑誌　98　(8)　S1803-S1803　2024年9月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
低弾性率チタン(TiNbSn)合金製ロッキングプレートはラット大腿骨骨切り部の骨癒合を促進する

古山和樹, 森優, 上村雅之, 田中秀達, 伊東健太郎, 古口昌志, 原田健登, 内海峻輔, 畠山拡, 正橋直哉, 相澤俊峰

日本整形外科学会雑誌　98　(8)　S1803-S1803　2024年9月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
Preserving medial iliofemoral ligament avoids excessive leg lengthening in total hip arthroplasty using anterolateral-supine approach

Kurishima Hiroaki, Yamada Norikazu, Noro Atsushi, Tanaka Hidetatsu, Takahashi Shusuke, Tsuchida Kyota, Mori Yu, Aizawa Toshimi

Journal of Orthopaedics　2024年9月

DOI： 10.1016/j.jor.2024.09.004 　
Surgery on admission and following day reduces hip fracture complications: a Japanese DPC study.

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Journal of bone and mineral metabolism　2024年7月11日

DOI： 10.1007/s00774-024-01534-2 　

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INTRODUCTION: The efficacy of early surgery in preventing complications among Japanese elderly patients with hip fractures requires further investigation. This study aims to use a comprehensive Japanese hip fracture case database to determine whether surgery within the day of admission and the following day reduces the incidence of complications and mortality during hospitalization in elderly hip fracture patients. MATERIALS AND METHODS: We retrospectively analyzed the Japanese National Administrative DPC (Diagnosis Procedure Combination) database from April 2016 to March 2022. Approximately 1100 DPC-affiliated hospitals consistently provided medical records with consent for research. The study investigated the association between postoperative pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization after propensity score matching, focusing on surgeries conducted on the day of admission and the following day. RESULTS: After one-to-one propensity score matching for age, gender, and comorbidity, we identified 146,441 pairs of patients who underwent surgery either within the day of admission and the following day or after the third day of admission. Surgery on the third day or later was independently associated with increased risks of pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization with risk ratios of 1.367 (95% CI 1.307-1.426), 1.328 (95% CI 1.169-1.508), 1.338 (95% CI 1.289-1.388), and 1.167 (95% CI 1.103-1.234), respectively. CONCLUSION: A comprehensive study of elderly Japanese patients with hip fractures in the DPC database showed that surgery on admission and the following day is crucial for preventing complications like pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization.
Harmony between spinopelvic mismatch and sagittal hip alignment contributes to upright standing in females: a cross-sectional study. 国際誌

Kazuyoshi Baba, Kohei Takahashi, Ko Hashimoto, Takahiro Onoki, Takashi Aki, Ryo Fujita, Keisuke Ishikawa, Toshimi Aizawa

Journal of spine surgery (Hong Kong)　10　(2)　244-254　2024年6月21日

DOI： 10.21037/jss-23-145 　

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BACKGROUND: In upright standing, spinopelvic mismatch is compensated by hip extension. However, few studies have investigated the reciprocal relationship between the sagittal alignment of the hip joints and spinopelvic mismatch during upright standing in humans. Our study aims to investigate (I) the relationship between spinopelvic mismatch and hip extension and (II) whether insufficient hip extension against spinopelvic mismatch, i.e., pelvic incidence (PI)-lumbar lordosis (LL), affects trunk inclination in upright standing. METHODS: This study was a retrospective cross-sectional study. We included 398 consecutive female patients treated for osteoporosis at our outpatient department between November 2017 and June 2022. Patients with any of the following were excluded from the study: (I) those whose plain whole-spine radiographs did not cover the femurs, (II) those with fractures in the vertebrae or lower extremities, (III) those with a history of surgery of the spine or of the lower extremities, (IV) those with scoliosis with a Cobb angle ≥10° in the anteroposterior radiograph, and (V) those with transitional vertebrae. Sixty-two patients were divided into normal and malalignment groups based on their sagittal spinal alignment. The patients underwent plain whole-spine radiography as a routine examination. A linear approximation between the pelvic femoral angle (PFA), representing hip extension, and PI-LL was obtained in both groups. The optimal PFA of each patient was obtained by substituting the PI-LL into the linear approximation of the normal group. The difference between the optimal and measured PFA was defined as the ΔPFA for each patient. The correlation between the ΔPFA and sagittal vertical axis (SVA) was evaluated in both groups. RESULTS: The PFA and PI-LL were correlated in both groups. The malalignment group had a significantly greater ΔPFA than the normal group. ΔPFA was correlated with SVA only in the malalignment group. CONCLUSIONS: The magnitude of the ΔPFA indicated insufficient hip extension to compensate for the spinopelvic mismatch during upright standing.
Acetabular coverage exerts minimal influence on femoral head collapse and the necessity for surgical intervention in patients with osteonecrosis of femoral head

Yasuaki Kuriyama, Hidetatsu Tanaka, Kazuyoshi Baba, Ryuichi Kanabuchi, Yu Mori, Toshimi Aizawa

International Orthopaedics　2024年6月20日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s00264-024-06238-w 　

ISSN：0341-2695

eISSN：1432-5195

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Abstract Purpose The acetabular coverage in osteonecrosis of the femoral head (ONFH) affects the need for surgical intervention, and the collapse of the femoral head remains unclear. This study aimed to evaluate the relation between the acetabular coverage and the need for surgical treatment and femoral head collapse. Methods The study included 158 patients with 252 hips with glucocorticoid administration and idiopathic ONHF without osteoarthritis changes. The mean age at the first visit was 45.2 years, and the mean follow-up period was 92.2 months. All ONFH hips were subsequently divided into two groups: those needing surgical intervention and those without surgery. Additionally, it divided 167 initially non-collapsed hips into those that either later collapsed or not. Radiographic parameters with the centre-edge angle, acetabular roof obliquity, sharp angle, and necrotic location, following the guidelines of the Japanese Investigation Committee, were evaluated. Results There were no significant differences in radiographic parameters between the 106 hips that underwent surgery and the 146 hips without surgery. Among the 167 hips without initial collapse, 91 eventually collapsed while 76 did not; their radiographic findings have no significant differences. The necrotic locations were significantly larger in hips requiring surgical intervention or femoral head collapse. Furthermore, 21.8% (55 out of 252 hips) had acetabular dysplasia, which did not significantly correlate with the necessity for surgical treatment or the incidence of femoral head collapse. Conclusions Acetabular coverage has little effect on the necessity for surgical treatment and femoral head collapse in ONFH patients over a long-term follow-up.
Location and Size of the Reverse Hill-Sachs Lesion in Patients with Traumatic Posterior Shoulder Instability. 国際誌

Kaijia Yang, Nobuyuki Yamamoto, Norimasa Takahashi, Hideki Kamijo, Kenji Okamura, Teruhisa Mihata, Hiroyuki Sugaya, Tadanao Funakoshi, Arino Atsushi, Jun Kawakami, Toshimi Aizawa, Eiji Itoi

Journal of shoulder and elbow surgery　2024年4月18日

DOI： 10.1016/j.jse.2024.03.017 　

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BACKGROUND: In patients with traumatic posterior shoulder instability, little is known about the precise location and size of the reverse Hill-Sachs lesion. METHODS: Forty-nine shoulders of 47 patients with traumatic posterior instability were included in this study based on the following inclusion criteria: 1) a primary or recurrent traumatic posterior shoulder dislocation, and 2) the initial event was caused by trauma. Patients were excluded if they had: 1) no history of trauma, 2) prior shoulder surgery, 3) no CT examination, or 4) seizure cases. Three-dimensional images of the humerus reconstructed from CT images were reviewed using an image analysis software. The location and size of the reverse Hill-Sachs lesion were measured and described on a clock face on the humeral head. RESULTS: The reverse Hill-Sachs lesion was observed in 25 of 49 shoulders (51%). The reverse Hill-Sachs lesions were located between 1:37 and 2:48. The depth of the reverse Hill-Sachs lesion (mean ± SD) was 5.8 ± 2.2 mm. The extent of the reverse Hill-Sachs lesion was 35° ± 12°. The average orientation of the reverse Hill-Sachs lesion, represented by an angle measured from the 12 o'clock position, was 64° ± 12° and pointing towards 2:09 on a clock face. Length and width of reverse Hill-Sachs lesions were 9.7 ± 4.7 mm, 11.1 ± 3.6 mm, respectively. CONCLUSION: The reverse Hill-Sachs lesion was a semicircular compression fracture located on the anteromedial aspect of the humeral head. Compared with shoulders with anterior shoulder instability, the humeral defect was smaller and located more inferiorly in shoulders with posterior instability.
A Review of the Impacts of Implant Stiffness on Fracture Healing

Yu Mori, Masayuki Kamimura, Kentaro Ito, Masashi Koguchi, Hidetatsu Tanaka, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Toshimi Aizawa

Applied Sciences　2024年3月7日

DOI： 10.3390/app14062259 　
Anterolateral supine approach THAにおける内閉鎖筋共同腱の解離が臨床転帰および股関節周囲筋筋力に与える影響は限定的である

田中秀達, 山田則一, 栗島宏明, 馬場一慈, 森優, 相澤俊峰

日本整形外科学会雑誌　98　(2)　S403-S403　2024年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
Clinical Outcomes of Bipolar Hemiarthroplasty with a Conjoined Tendon-Preserving Posterior Approach for Femoral Neck Fractures

Tanaka, H., Mori, Y., Noro, A., Yano, T., Aizawa, T., Masuda, K.

Medicina (Lithuania)　60　(3)　2024年2月21日

DOI： 10.3390/medicina60030356 　

ISSN：1648-9144 1010-660X
Efficacy of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite Implantation for Miniature Swine Lumbar Interbody Fusion

Yu Mori, Ryo Hamai, Ryuichi Kanabuchi, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa, Osamu Suzuki

The Tohoku Journal of Experimental Medicine　2024年
出版者・発行元： Tohoku University Medical Press
DOI： 10.1620/tjem.2024.j138 　

ISSN：0040-8727

eISSN：1349-3329
どこへいく?どうなる?脊椎内視鏡の教育脊椎内視鏡下手術がゴールドスタンダードになるために新時代の教育・普及活動

山屋誠司, 橋本功, 古泉豊, 矢部裕, 須田英明, 千葉美詩央, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本内視鏡外科学会雑誌　28　(7)　1054-1054　2023年12月
出版者・発行元： (一社)日本内視鏡外科学会
ISSN：1344-6703

eISSN：2186-6643
Reliability of Conventional Two-Dimensional Magnetic Resonance Imaging for Diagnosing Extraforaminal Stenosis in Lumbosacral Transition.

Kohei Takahashi, Myo Min Latt, Takumi Tsubakino, Manabu Suzuki, Takeshi Nakamura, Takeshi Hoshikawa, Tomowaki Nakagawa, Ko Hashimoto, Takahiro Onoki, Toshimi Aizawa, Yasuhisa Tanaka

Spine surgery and related research　7　(6)　526-532　2023年11月27日

DOI： 10.22603/ssrr.2023-0110 　

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INTRODUCTION: Three-dimensional (3D) magnetic resonance imaging (MRI) is reportedly superior to two-dimensional (2D) MRI for diagnosing lumbar foraminal stenosis at L5-S1. In this study, we strictly distinguished the intra- and extraforaminal regions and compared the diagnostic reliability and accuracy of 2D and 3D MRI in each region. METHODS: A total of 92 surgical cases of unilateral L5 radiculopathy were selected for imaging analysis, including 46 of foraminal stenosis at L5-S1 (Group F) and 46 of intraspinal canal stenosis at L4-5 (Group C) (48 men, 44 women; mean age, 66 years). The 2D and 3D MRI sets were assessed twice by two examiners. They were informed only of the laterality of the lesion in each case and asked to select among the following for each modality: "absence of foraminal stenosis," "intraforaminal stenosis," "extraforaminal stenosis," and "coincident intraforaminal and extraforaminal stenosis." The intra- and interobserver reliabilities were evaluated using kappa (κ) statistics for the intra- and extraforaminal regions and compared between 2D and 3D MRI. For each case, disagreements between examiners were resolved through discussion to obtain a diagnostic judgment for each modality. Subsequently, the final diagnosis of intra- and/or extraforaminal stenosis in Group F was made using multiple modalities and intraoperative findings. A comparison between 2D and 3D MRI in terms of diagnostic accuracy was performed for the intra- and extraforaminal regions. RESULTS: No significant difference was observed in the κ statistics between 2D and 3D MRI for the intraforaminal region, whereas 3D MRI had significantly larger κ statistic than 2D MRI for the extraforaminal region. Ultimately, 3D MRI perfectly judged the extraforaminal region, whereas 2D MRI detected only 44.8% of the cases of extraforaminal stenosis. CONCLUSIONS: More than half of extraforaminal stenosis was overlooked by 2D MRI, suggesting that it is unreliable for diagnosing extraforaminal stenosis at L5-S1.
Are T1-Weighted Three-Dimensional Magnetic Resonance Images Inferior to T2-Weighted Images for Diagnosing Lumbar Foraminal Stenosis in the Fifth Lumbar Nerve Root? A Prospective, Comparative Study in Identical Patients.

Ko Hashimoto, Yasuhisa Tanaka, Takumi Tsubakino, Takeshi Hoshikawa, Chikashi Kawahara, Tomowaki Nakagawa, Satoshi Tateda, Kohei Takahashi, Manabu Suzuki, Takahiro Onoki, Haruo Kanno, Naoki Morozumi, Yutaka Koizumi, Masahito Honda, Takashi Kusakabe, Masaru Suda, Shoichi Kokubun, Toshimi Aizawa

Spine surgery and related research　7　(5)　436-442　2023年9月27日

DOI： 10.22603/ssrr.2023-0026 　

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INTRODUCTION: Imaging analysis of foraminal stenosis in the fifth lumbar (L5) nerve root remains to be a challenge because of the anatomical complexity of the lumbosacral transition. T2-weighted three-dimensional (3D) magnetic resonance images (MRI) have been dominantly used for diagnosis of lumbar foraminal stenosis, while the reliability of T1-weighted images (WI) has also been proven. In this study, we aim to compare the reliability and reproducibility of T1- and T2-weighted 3D MRI in diagnosing lumbar foraminal stenosis (LFS) of the L5 nerve root. METHODS: In this study, 39 patients with unilateral L5 radiculopathy (20 had L4-L5 intracanal stenosis; 19 had L5-S foraminal stenosis) were enrolled, prospectively. T1- and T2-weighted 3D lumbar MRI were obtained from each patient. T1WI and T2WI were blinded and then separately reviewed twice by four examiners randomly. The examiners were instructed to answer the side of LFS or absence of LFS. The correct answer rate, sensitivity, specificity, and area under the curve were analyzed and compared between T1WI and T2WI. Also, intra- and interobserver agreements were calculated using kappa (κ)-statistics and compared in the same manner. RESULTS: The average correct answer rate, sensitivity, specificity, and area under the curve of the T1WI/T2WI were 84.6%/80.1%, 82.9%/80.3%, 86.3%/81.3%, and 0.846/0.801, respectively. The intraobserver κ-values of the four examiners ranged from 0.692 to 0.916 (average: 0.762) and from 0.669 to 0.801 (average: 0.720) for T1WI and T2WI, respectively. The interobserver κ-values calculated in a round-robin manner (24 combinations in total) ranged from 0.544 to 0.790 (average: 0.657) and from 0.524 to 0.828 (average: 0.652), respectively. CONCLUSIONS: As per our findings, T1- and T2-weighted 3D MRI were determined to have nearly equivalent reliability and reproducibility in terms of diagnosing LFS of the L5 nerve root.
Radical decompression without fusion for L5 radiculopathy due to foraminal stenosis. 国際誌

Kohei Takahashi, Ajay Yadav, Takumi Tsubakino, Takeshi Hoshikawa, Tomowaki Nakagawa, Ko Hashimoto, Manabu Suzuki, Toshimi Aizawa, Yasuhisa Tanaka

Journal of spine surgery (Hong Kong)　9　(3)　278-287　2023年9月22日

DOI： 10.21037/jss-23-62 　

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BACKGROUND: The highest incidence of lumbar foraminal stenosis (LFS) occurs in the L5-S1 segment and its anatomical features differ from those of other segments. Few previous reports have exhaustively assessed surgical outcomes after decompression surgery, limiting the materials to patients with LFS at the L5-S1 segment. We aimed to prospectively investigate instability and neurological improvement following our novel surgical technique for LFS at L5-S1, named "radical decompression" of the nerve root. METHODS: Patients with foraminal stenosis at L5-S1 who underwent surgery using our technique were prospectively evaluated two years postoperatively. The Japanese Orthopaedic Association (JOA) score and the JOA Back Pain Evaluation Questionnaire (JOABPEQ) were evaluated preoperatively and two years postoperatively. The following radiological parameters at L5-S1 were measured: lateral translation, sagittal translation, the difference in sagittal translation (DST) between flexion and extension, disc wedging angle, lordotic angle, the difference in lordotic angle (DLA) between flexion and extension, and disc height. Pre- and postoperative data were compared using paired t-tests. In addition, the patients were classified into a disc group (Group D) and a non-disc group (Group ND) according to whether a discectomy was performed intraoperatively. Changes in each parameter before and after surgery were compared between the groups. RESULTS: Twenty-eight patients were included in this analysis. The JOA scores improved in all patients. The mean preoperative and two-year postoperative JOA scores were 14.5±3.2 (range, 8-21) and 24.3±3.3 (range, 18-29), respectively (P<0.01). All JOABPEQ categories improved two years postoperatively (P<0.05). None of the patients underwent revision surgery. No significant changes were observed in any of the radiological parameters. No significant differences in the changes in each parameter before and after surgery were found between groups D and ND. CONCLUSIONS: Our surgical technique resulted in good neurological recovery and was associated with a low risk of postoperative segmental instability, regardless of additional discectomy.
鏡視下上方関節包再建術後の外旋改善は三角筋後部線維による

有野敦司, 山本宣幸, 佐々木一真, 木村礼, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　50回・20回　189-189　2023年9月
出版者・発行元： (一社)日本肩関節学会
鏡視下上方関節包再建術後の外旋改善は三角筋後部線維による

有野敦司, 山本宣幸, 佐々木一真, 木村礼, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　50回・20回　189-189　2023年9月
出版者・発行元： (一社)日本肩関節学会
MR画像を用いた軌跡外損傷評価の改善

木村礼, 山本宣幸, 有野敦司, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　50回・20回　293-293　2023年9月
出版者・発行元： (一社)日本肩関節学会
Primary Malignant Lymphoma of the Cauda Equina Diagnosed after Decompression for Lumbar Spinal Stenosis: A Case Report.

Manabu Suzuki, Kohei Takahashi, Mika Watanabe, Ko Hashimoto, Takahiro Onoki, Kyoichi Handa, Toshimi Aizawa

The Tohoku journal of experimental medicine　260　(4)　341-346　2023年8月23日

DOI： 10.1620/tjem.2023.J047 　

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Primary malignant lymphoma confinement to the cauda equina is rare. Only 14 cases of primary malignant lymphoma in the cauda equina have been reported. In these cases, the clinical features were similar to those of lumbar spinal canal stenosis (LSCS). This report describes a case of diffuse large B-cell lymphoma of the cauda equina that was diagnosed after decompression surgery for LSCS. An 80-year-old man presented with gait disturbance due to progressive muscle weakness in the lower extremities over the previous two months. He was diagnosed with LSCS, and decompression surgery was performed. However, the muscle weakness worsened after surgery; therefore, he was referred to our department. Plain magnetic resonance imaging (MRI) revealed swelling of the cauda equina. It demonstrated marked homogenous enhancement by gadolinium-diethylenetriamine pentaacetic acid. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) revealed diffuse accumulation of 18F-FDG in the cauda equina. These imaging findings were consistent with those of cauda equina lymphomas. To confirm the diagnosis, we performed an open biopsy of the cauda equina. Histological examination indicated diffuse large B-cell lymphoma. Considering the patient's age and activities of daily living, further treatment was not performed. The patient died four months after the first surgery. Rapid progression of muscle weakness, which cannot be prevented by decompression surgery, and swollen cauda equina on MRI may be signs of this disorder. Gadolinium-enhanced MRI, 18F-FDG PET, and histological investigation of the cauda equina should be performed for diagnosing primary malignant lymphoma of the cauda equina.
人工股関節全置換術前の口腔ケアは全例で必要か? 口腔ケアが必要な感染高リスク症例の抽出法の検討

馬塲一慈, 千葉大介, 森優, 金淵龍一, 栗山恭明, 栗島宏明, 鈴木貴之, 濱田壮志, 相澤俊峰

Hip Joint　49　(1)　57-59　2023年8月
出版者・発行元：日本股関節学会
ISSN：0389-3634

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当院整形外科では2018年からTHA患者には手術前に当院歯科を受診してもらい、歯科治療が必要であればTHA前に治療を行う「口腔ケア」を導入し、2020年以降は再置換術例も含むTHA全例に口腔ケアを実施しているが、全例のケアは患者・医療者とも負担がかかる。そこで、口腔ケアが必要な感染高リスク症例を術前に選定できれば負担を軽減できると考え、選定するツールとして、2018年に報告された「人工関節置換術前に関節周囲感染の発生を予測するスコアリングシステム」が有用であるか検討した。口腔ケア導入前の2017年度のTHA患者50例と、口腔ケアを全例に実施した2020年度の患者68例のデータをもとに検討した結果、口腔ケアが必要な患者の選定に同スコアリングシステムは有用でないことが示唆された。
腱板断裂患者における脂肪化と筋萎縮平均6年の前向き調査

有野敦司, 山本宣幸, 川上純, 木村礼, 藍澤一穂, 永元英明, 佐野博高, 相澤俊峰, 井樋栄二

東日本整形災害外科学会雑誌　35　(3)　335-335　2023年8月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
脊椎後彎症患者の変形矯正術前後で股関節の運動学的特性はどう変化するか? 三次元動作解析装置を用いた歩行解析による検討

藤田涼, 高橋康平, 関口雄介, 鎌田久美, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　97　(8)　S1841-S1841　2023年8月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
TiNbSn stems with gradient changes of Young’s modulus and stiffness reduce stress shielding compared to the standard fit-and-fill stems

Kazuyoshi Baba, Yu Mori, Daisuke Chiba, Yoshiyuki Kuwahara, Hiroaki Kurishima, Hidetatsu Tanaka, Atsushi Kogure, Masayuki Kamimura, Norikazu Yamada, Susumu Ohtsu, Masamizu Oyama, Naoya Masahashi, Shuji Hanada, Eiji Itoi, Toshimi Aizawa

European Journal of Medical Research　28　(1)　2023年7月3日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/s40001-023-01199-z 　

eISSN：2047-783X

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Abstract Background The difference between Young’s moduli of the femur and the stem causes stress shielding (SS). TiNbSn (TNS) stem has a low Young’s modulus and strength with gradient functional properties during the change in elastic modulus with heat treatment. The aim of this study was to investigate the inhibitory effect of TNS stems on SS and their clinical outcomes compared to conventional stems. Methods This study was a clinical trial. Primary THA was performed using a TNS stem from April 2016 to September 2017 for patients in the TNS group. Unilateral THA was performed using a Ti6Al4V alloy stem from January 2007 to February 2011 for patients in the control group. The TNS and Ti6Al4V stems were matched in shape. Radiographs were obtained at the 1- and 3-year follow-ups. Two surgeons independently checked the SS grade and appearance of cortical hypertrophy (CH). The Japanese Orthopaedic Association (JOA) scores before and 1 year after surgery were assessed as clinical scores. Results None of the patients in the TNS group had grade 3 or 4 SS. In contrast, in the control group, 24% and 40% of patients had grade 3 and 4 SS at the 1- and 3-year follow-ups, respectively. The SS grade was lower in the TNS group than in the control group at the 1- and 3-year follow-ups (p < 0.001). The frequencies of CH in both groups were no significant difference at the 1- and 3-year follow-ups. The JOA scores of the TNS group significantly improved at 1 year after surgery and were comparable to control group. Conclusion The TNS stem reduced SS at 1 and 3 years after THA compared to the proximal-engaging cementless stem, although the shapes of the stems matched. The TNS stem could reduce SS, stem loosening, and periprosthetic fractures. Trial registration: Current Controlled Trials. ISRCTN21241251. https://www.isrctn.com/search?q=21241251. The date of registration was October 26, 2021. Retrospectively registered.
THREE-COLUMN OSTEOTOMY WITH COMBINATION OF COMPRESSION HOOK AND PEDICLE SCREW FIXATION FOR ADULT SPINAL DEFORMITY IN PATIENTS WITH PARKINSON’S DISEASE

Haruo Kanno, Ko Hashimoto, Kohei Takahashi, Kyoichi Handa, Toshimi Aizawa, Hiroshi Ozawa

Journal of Musculoskeletal Research　26　(02)　2023年6月30日
出版者・発行元： World Scientific Pub Co Pte Ltd
DOI： 10.1142/s0218957723400055 　

ISSN：0218-9577

eISSN：1793-6497

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Purpose: Surgical treatment for adult spinal deformity (ASD) in patients with Parkinson’s disease (PD) is challenging and is associated with a significant risk of postoperative mechanical complications, such as rod breakage, pseudoarthrosis and proximal junctional failure. We herein report the surgical results of three-column osteotomy with pedicle screw fixation combined with compression hook for ASD associated with PD. Methods: We retrospectively investigated four patients with ASD due to PD who underwent three-column osteotomy with posterior instrumentation. The compression hook system placed on the laminae was used for closure of the osteotomy site during surgery and reinforcement of pedicle screw fixation. Surgical outcomes and radiographical parameters were analyzed. Results: Lumbar lordosis was improved from [Formula: see text] preoperatively to [Formula: see text] postoperatively, and [Formula: see text] at the final follow-up examination. The sagittal vertical axis was restored from 297 ± 104 mm preoperatively to 41 ± 13 mm postoperatively, and 72 ± 23 mm at the final follow-up examination. The preoperative VAS (88 ± 14 mm) for low back pain was significantly improved at the final follow-up examination (14 ± 28 mm). Walking disturbance due to low back pain was improved in all patients. No patients had mechanical failure (e.g. rod fracture, pseudarthrosis, or junctional failure) after surgery. Conclusion: The use of compression hooks to supplement pedicle screw fixation is beneficial for performing safe osteotomy closure during surgery and preventing postoperative mechanical failures, and may be a useful option when performing three-column osteotomy for ASD associated with PD.
PJI 人工関節周囲感染診断におけるalpha-defensin検査の有用性について

森優, 千葉大介, 上村雅之, 金淵龍一, 馬場一慈, 相澤俊峰

日本骨・関節感染症学会プログラム・抄録集　46回　108-108　2023年6月
出版者・発行元： (一社)日本骨・関節感染症学会
関節鏡視下に切除を行った上腕骨頭発生類骨骨腫の一例

有野敦司, 吉田新一郎, 岩津潤, 綿貫宗則, 山本宣幸, 相澤俊峰, 常陸真, 渡邉みか

東北整形災害外科学会雑誌　66　(1)　166-167　2023年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
Long-term results of Chiari pelvic osteotomy on the preservation of hip function with mean follow-up of more than 30 years and its prognostic factors

Hiroaki Kurishima, Daisuke Chiba, Kazuyoshi Baba, Soshi Hamada, Takayuki Suzuki, Ryuichi Kanabuchi, Genji Fujii, Masamizu Oyama, Tatsuhiro Ochiai, Yu Mori, Toshimi Aizawa

Journal of Orthopaedic Science　2023年6月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.jos.2023.05.013 　

ISSN：0949-2658
Facet cysts in the subaxial cervical spine: Case series focused on radiological and histopathological findings with a scoping review.

Takashi Kusakabe, Takeshi Nakamura, Naoki Morozumi, Fumio Kasama, Shigetsune Matsuya, Takahiro Onoki, Toshimi Aizawa

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　28　(3)　521-528　2023年5月

DOI： 10.1016/j.jos.2022.01.017 　

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BACKGROUND: Facet cysts in the subaxial cervical spine are a relatively rare cause of neuropathy. This case series aimed to investigate the radiological and histopathological features and surgical results of these lesions, and provide possible mechanisms of cyst development. METHODS: Thirteen subaxial cervical facet cysts in 12 patients were diagnosed on the basis of magnetic resonance imaging and computed tomography with facet arthrography. Surgical outcomes were evaluated according to the Japanese Orthopaedic Association scores for cervical myelopathy, or Tanaka's scores for cervical radiculopathy. These results were presented in combination with a scoping review of the literature. RESULTS: Seven cysts were found in the posteromedial region, and six in the posterolateral portion of the spinal canal. Computed tomography revealed degeneration of all involved facet joints. All patients underwent decompression, and the mean recovery rates of Japanese Orthopaedic Association scores and Tanaka's scores were 57.1% and 87.5%, respectively. Histopathologically, all cysts were continuous with the degenerated ligamentum flavum. In the scoping review, the patients' mean age was 65.1 years. The cysts were distributed as follows: 3.6% at C2-3, 10.7% at C3-4, 14.3% at C4-5, 5.4% at C5-6, 7.1% at C6-7, and 58.9% at C7-T1. The presenting symptoms were myelopathy (49.4%) and radiculopathy (50.0%). Radiologically, 55% and 45% of the cysts were of the posteromedial and posterolateral types. Of the patients, 76.9% underwent decompression only, and 23.1% had concomitant fusion. Cyst recurrence was not observed in the mean follow-up period of 15.1 months. CONCLUSIONS: The pathogenesis of cysts is closely related to degenerative changes in the facet joint and ligamentum flavum, and rupture in degenerated ligaments can develop into a cavity, which contributes to cyst formation. The scoping review suggests that cyst resection generally results in positive outcomes without recurrence in either decompression alone or concomitant fusion.
【人工関節における進歩】バイオマテリアル金属素材と表面加工チタン合金・低弾性チタン合金低弾性チタン合金,チタン-ニオブ-スズ合金で開発した人工股関節ステムの成績と今後の展望

千葉大介, 山田則一, 森優, 馬場一慈, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

別冊整形外科　(83)　9-12　2023年4月
出版者・発行元： (株)南江堂
ISSN：0287-1645

eISSN：2433-4316

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セメントレスステムの問題点の一つに応力遮蔽がある。現在もっともよく使用されているセメントレスステムはTi-6Al-4V合金で作られており、同合金は生体適合性がよく、耐食性にも優れている一方、Young率が110GPaと高く、これが応力遮蔽の原因の一つと考えられている。本学金属材料研究所で開発されたチタン-ニオブ-スズ合金(以下TNS合金)は、熱を加えることで強度やYoung率を変化させることのできる画期的な新合金であり、生体材料としての安全性と有用性については基礎実験で確認されている。今回、TNS合金の臨床応用を始めて術後平均3年が経過したので、その成績を報告した。対象は40例40関節で、放射線学的評価の方法は、術後3ヵ月・6ヵ月・1年・3年時に股関節X線撮影を行い、Engh分類に従って応力遮蔽の評価を行った。臨床学的評価は術前と術後6週・3ヵ月・6ヵ月・1年時にJOAスコアとJHEQによる評価を行った。放射線学的評価の結果、術後3年で応力遮断を26関節(65%)に認めたが、その程度はgrade 1が16関節、grade 2が10関節であり、grade 3以上はなかった。臨床学的評価の結果、JOAスコアは術前平均47.4±9.6点が術後1年時84.9±8.6点に改善し、JHEQスコアは術前平均18.1±9.5点が術後1年時57.5±11.7点に改善した。
【人工関節における進歩】バイオマテリアル金属素材と表面加工チタン合金・低弾性チタン合金低弾性チタン合金,チタン-ニオブ-スズ合金で開発した人工股関節ステムの成績と今後の展望

千葉大介, 山田則一, 森優, 馬場一慈, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

別冊整形外科　(83)　9-12　2023年4月
出版者・発行元： (株)南江堂
ISSN：0287-1645

eISSN：2433-4316
Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway

Yu Mori, Kazuko Ueno, Daisuke Chiba, Ko Hashimoto, Yosuke Kawai, Kazuyoshi Baba, Hidetatsu Tanaka, Takashi Aki, Masanori Ogasawara, Naoto Shibasaki, Katsushi Tokunaga, Toshimi Aizawa, Masao Nagasaki

International Journal of Molecular Sciences　24　(5)　5019-5019　2023年3月6日
出版者・発行元： MDPI AG
DOI： 10.3390/ijms24055019 　

eISSN：1422-0067

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This study examined the association between developmental dysplasia of the hip (DDH) and disease-associated loci in a Japanese cohort. A genome-wide association study (GWAS) of 238 Japanese patients with DDH and 2044 healthy individuals was performed. As a replicate, GWAS was also conducted on the UK Biobank data with 3315 cases and matched 74,038 controls. Gene set enrichment analyses (GSEAs) of both the genetics and transcriptome of DDH were performed. Transcriptome analysis of cartilage specimens from DDH-associated osteoarthritis and femoral neck fractures was performed as a control. Most of the lead variants were very low-frequency ones in the UK, and variants in the Japanese GWAS could not be replicated with the UK GWAS. We assigned DDH-related candidate variants to 42 and 81 genes from the Japanese and UK GWASs, respectively, using functional mapping and annotation. GSEA of gene ontology, disease ontology, and canonical pathways identified the most enriched pathway to be the ferroptosis signaling pathway, both in the Japanese gene set as well as the Japanese and UK merged set. Transcriptome GSEA also identified significant downregulation of genes in the ferroptosis signaling pathway. Thus, the ferroptosis signaling pathway may be associated with the pathogenic mechanism of DDH.
若年スポーツ選手における腰痛の頻度競技種目ごとの検討

矢部裕, 萩原嘉廣, 大野木孝嘉, 石川圭佑, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S73-S73　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
網羅的なタンパク解析による黄色靱帯肥厚の病態解明

矢部裕, 萩原嘉廣, 大野木孝嘉, 石川圭佑, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S318-S318　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 千葉大介, 橋本功, 馬場一慈, 田中秀達, 植野和子, 長崎正朗, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S115-S115　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 綿貫宗則, 吉田新一郎, 森菜緒子, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S888-S888　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
新規に開発した同一stem内で剛性が変化するstem(TiNbSn stem)のstress shielding予防効果

馬場一慈, 千葉大介, 森優, 田中秀達, 小暮敦史, 桑原功行, 山田則一, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S1114-S1114　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
腱板断裂患者における脂肪化と筋萎縮平均6年の前向き調査

有野敦司, 山本宣幸, 木村礼, 藍澤一穂, 川上純, 永元英明, 佐野博高, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　97　(2)　S147-S147　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
肩関節外科に必要な解剖学関節唇および関節包靱帯の解剖および機能

山本宣幸, 有野敦司, 藍澤一穂, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　97　(2)　S515-S515　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
症候性腱板断裂患者の関節軟骨の変化平均6年の前向き研究

川上純, 山本宣幸, 有野敦司, 木村礼, 藍澤一穂, 佐野博高, 永元英明, 常陸真, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　97　(3)　S816-S816　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
関節窩骨欠損とHill-Sachs損傷の大きさの関係

高橋忠久, 山本宣幸, 有野敦司, 藍澤一穂, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　97　(3)　S1051-S1051　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
TiNbSn合金で開発した人工股関節ステムの5年以上経過例の中期成績

千葉大介, 山田則一, 大山正瑞, 大津進, 桑原功行, 馬場一慈, 田中秀達, 花田修治, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S219-S219　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
若年スポーツ選手における腰痛の頻度競技種目ごとの検討

矢部裕, 萩原嘉廣, 大野木孝嘉, 石川圭佑, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S73-S73　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
網羅的なタンパク解析による黄色靱帯肥厚の病態解明

矢部裕, 萩原嘉廣, 大野木孝嘉, 石川圭佑, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S318-S318　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
脊椎後彎症患者の立位静止時および歩行時の体幹前傾と股関節肢位の関係 3D動作解析装置とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S794-S794　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 千葉大介, 橋本功, 馬場一慈, 田中秀達, 植野和子, 長崎正朗, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S115-S115　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 綿貫宗則, 吉田新一郎, 森菜緒子, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S888-S888　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
新規に開発した同一stem内で剛性が変化するstem(TiNbSn stem)のstress shielding予防効果

馬場一慈, 千葉大介, 森優, 田中秀達, 小暮敦史, 桑原功行, 山田則一, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S1114-S1114　2023年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
Two-stage revision knee arthroplasty for metallosis in a patient with rheumatoid arthritis: A case report

Tomoki Koyama, Yu Mori, Masayuki Kamimura, Takashi Aki, Takuya Izumiyama, Naoko Mori, Daisuke Chiba, Ko Hashimoto, Nobuyuki Yamamoto, Toshimi Aizawa

SAGE Open Medical Case Reports　2023年1月

DOI： 10.1177/2050313X231177752 　
Anterior shift of the ventral dura mater: A novel concept of the posterior surgery for ossification of the posterior longitudinal ligament in thoracic spine. 国際誌

Kohei Takahashi, Ko Hashimoto, Takahiro Onoki, Haruo Kanno, Hiroshi Ozawa, Toshimi Aizawa

Frontiers in surgery　10　1120069-1120069　2023年

DOI： 10.3389/fsurg.2023.1120069 　

詳細を見る詳細を閉じる

BACKGROUND: Thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) remains one of the most difficult disorders to treat. The Ohtsuka procedure, extirpation, or anterior floating of the OPLL through a posterior approach, has shown great surgical outcomes after several modifications. However, these procedures are technically demanding and pose a significant risk of neurological deterioration. We have developed a novel modified Ohtsuka procedure in which removal or minimization of the OPLL mass is unnecessary; instead, the ventral dura mater is shifted anteriorly with the posterior part of the vertebral bodies and targeted OPLL. SURGICAL PROCEDURE: First, pedicle screws were inserted at more than three spinal levels above and below the spinal level where pediculectomies were performed. After laminectomies and total pediculectomies, partial osteotomy of the posterior vertebra adjacent to the targeted OPLL was performed by using a curved air drill. Then, the PLL is completely resected at the cranial and caudal sites of the OPLL using special rongeurs or a threadwire saw with a diameter of 0.36 mm. The nerve roots were not resected during surgery. METHODS: Eighteen patients (follow-up ≥1 year) treated with our modified Ohtsuka procedure were assessed clinically, including the Japanese Orthopaedic Association (JOA) score for thoracic myelopathy and radiographically. RESULTS: The average follow-up period was 3.2 years (range, 1.3-6.1 years). The preoperative JOA score was 2.7 ± 1.7, which improved to 8.2 ± 1.8 at 1 year postoperatively; therefore, the recovery rate was 65.8 ± 19.8%. The CT scan at 1 year after surgery revealed the anterior shift of the OPLL averaged 3.1 ± 1.7 mm and the ossification-kyphosis angle of the anterior decompression site decreased at an average of 7.2 ± 6.8 degrees. Three patients demonstrated temporary neurological deterioration, all of whom completely recovered within 4 weeks postoperatively. DISCUSSION: The concept of our modified Ohtsuka procedure is 1) not OPLL extirpation or minimization but only the creation of space between the OPLL and spinal cord by an anterior shift of the ventral dura mater, which is achieved by complete resection of the PLL at the cranial and caudal sites of the OPLL; and 2) no nerve roots are sacrificed to prevent ischemic spinal cord injury. This procedure is not technically demanding and safe and provides secure decompression for thoracic OPLL. The anterior shift of the OPLL was smaller than expected, but it resulted in a relatively good surgical outcome with a recovery rate ≥65%. CONCLUSION: Our modified Ohtsuka procedure is quite secure and is not technically demanding, with a recovery rate of 65.8%.
A modified minimally invasive surgery for thoracic pyogenic spondylitis: Percutaneous pedicle screw fixation in combination with a vertebral debridement in a separate posterolateral approach—A case report

Yuki Sato, Ko Hashimoto, Michiharu Matsuda, Takahiro Onoki, Masayuki Kamimura, Kohei Takahashi, Yoshito Onoda, Daisuke Chiba, Yu Mori, Haruo Kanno, Nobuyuki Yamamoto, Toshimi Aizawa

Clinical Case Reports　10　(12)　2022年12月
出版者・発行元： Wiley
DOI： 10.1002/ccr3.6710 　

ISSN：2050-0904

eISSN：2050-0904
Impacts of external rotators and the ischiofemoral ligament on preventing excessive internal hip rotation: a cadaveric study

Kazuyoshi Baba, Daisuke Chiba, Yu Mori, Yoshiyuki Kuwahara, Atsushi Kogure, Takehiro Sugaya, Kumi Kamata, Itsuki Oizumi, Takayuki Suzuki, Hiroaki Kurishima, Soshi Hamada, Eiji Itoi, Toshimi Aizawa

Journal of Orthopaedic Surgery and Research　17　(1)　2022年12月
出版者・発行元： Springer Science and Business Media {LLC}
DOI： 10.1186/s13018-021-02873-w 　

ISSN：1749-799X

詳細を見る詳細を閉じる

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>This study examined the biomechanics of preventing excessive internal hip joint rotation related to the hip flexion angle.</jats:p> </jats:sec><jats:sec> <jats:title>Method</jats:title> <jats:p>An intramedullary nail with a circular plate equipped with a protractor was installed in the femur of nine normal hips. The circular plate was pulled by 3.15 Nm of force in the internal rotation direction. The external rotators were individually resected, finally cutting the ischiofemoral ligament. The cutting order of the external rotators differed on each side to individually determine the internal rotation resistance. The external rotators were resected from the piriformis to the obturator externus in the right hips and the reverse order in the left hips. Traction was performed after excising each muscle and ischiofemoral ligament. Measurements were taken at 0°, 30°, and 60° of hip flexion, and the differences from baseline were calculated.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>For the right hip measurements, the piriformis and ischiofemoral ligament resection significantly differed at 0° of flexion (p = 0.02), each external rotator and the ischiofemoral ligament resections significantly differed at 30° of flexion (p < 0.01), and the ischiofemoral ligament and piriformis and inferior gemellus resections significantly differed at 60° of flexion (p = 0.04 and p = 0.02, respectively). In the left hips, the ischiofemoral ligament and obturator externus, inferior gemellus, and obturator internus resections significantly differed at 0° of flexion (p < 0.01, p < 0.01, and p = 0.01, respectively), as did each external rotator and the ischiofemoral ligament resections at 30° of flexion (p < 0.01).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The ischiofemoral ligament primarily restricted the internal rotation of the hip joint. The piriformis and obturator internus may restrict internal rotation at 0° and 60° of flexion.</jats:p> </jats:sec>
How much force is acting on the shoulder joint to create a Hill-Sachs Lesion or reverse Hill-Sachs Lesion?

Toshimitsu Etoh, Nobuyuki Yamamoto, Jun Kawakami, Masayuki Kamimura, Daisuke Chiba, Yu Mori, Ko Hashimoto, Toshimi Aizawa, Eiji Itoi

Journal of Orthopaedic Science　2022年10月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.jos.2022.09.016 　

ISSN：0949-2658
体外衝撃波による膝関節拘縮の予防効果ラット拘縮モデルを用いた検討

岩津潤, 萩原嘉廣, 矢部裕, 金澤憲治, 板谷信行, 曽木靖仁, 西條芳文, 相澤俊峰

日本整形外科学会雑誌　96　(8)　S1668-S1668　2022年9月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325

eISSN：2758-7479
関節窩骨欠損とHill-Sachs損傷の大きさの関係

高橋忠久, 山本宣幸, 有野敦司, 藍澤一穂, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　135-135　2022年9月
出版者・発行元： (一社)日本肩関節学会
Latarjet法術後の移植骨の形態変化骨欠損の大小による比較

山本宣幸, 有野敦司, 藍澤一穂, 高橋忠久, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　140-140　2022年9月
出版者・発行元： (一社)日本肩関節学会
症候性腱板断裂患者の関節軟骨の変化平均6年の前向き研究

川上純, 山本宣幸, 有野敦司, 木村礼, 藍澤一穂, 永元英明, 佐野博高, 常陸真, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　149-149　2022年9月
出版者・発行元： (一社)日本肩関節学会
腱板断裂患者における脂肪化と筋萎縮平均6年の前向き調査

有野敦司, 山本宣幸, 川上純, 木村礼, 藍澤一穂, 永元英明, 佐野博高, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　150-150　2022年9月
出版者・発行元： (一社)日本肩関節学会
早期腱板断裂性関節症の調査 MRIによる軟骨の厚さの評価

木村礼, 山本宣幸, 有野敦司, 藍澤一穂, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　163-163　2022年9月
出版者・発行元： (一社)日本肩関節学会
β-type TiNbSn Alloy Plates with Low Young Modulus Accelerates Osteosynthesis in Rabbit Tibiae

Kentaro Ito, Yu Mori, Masayuki Kamimura, Masashi Koguchi, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Shuji Hanada, Eiji Itoi, Toshimi Aizawa

Clinical Orthopaedics and Related Research　480　(9)　1817-1832　2022年9月1日

DOI： 10.1097/CORR.0000000000002240 　

ISSN：0009-921X

eISSN：1528-1132
Extracorporeal shockwave therapy in an immobilized knee model in rats prevents progression of joint contracture. 国際誌

Jun Iwatsu, Yutaka Yabe, Kenji Kanazawa, Nobuyuki Itaya, Yasuhito Sogi, Yoshihumi Saijo, Toshimi Aizawa, Yoshihiro Hagiwara

Journal of orthopaedic research : official publication of the Orthopaedic Research Society　41　(5)　951-961　2022年8月28日

DOI： 10.1002/jor.25433 　

詳細を見る詳細を閉じる

Joint immobilization, which ensures rest and accelerates tissue recovery in musculoskeletal disorders, often causes joint contracture, for which there is still no effective prevention. To address this, we investigated the effects of extracorporeal shockwave therapy (ESWT) in preventing joint contracture, in a unilaterally immobilized knee rat model. Under general anesthesia, ESWT (0.25 mJ/mm2 , 3000 shot, 4 Hz, 3 d/week) was administered from one day after immobilization up to 2, 4, and 6 weeks. The immobilized control group received general anesthesia without ESWT. We evaluated joint angle, tissue elasticity, and gene and protein expression related to fibrosis, inflammation, and angiogenesis in the joint capsule. Relative to the control, the ESWT group had greater joint angle at 4 and 6 weeks, and lower posterior-capsule elasticity at 6 weeks. In the ESWT group, at 6 weeks, gene expression of collagen type I (col1α1), connective tissue growth factor (CTGF), and α-smooth muscle actin (α-SMA) was significantly downregulated, whereas interleukin-6 (IL-6) and hypoxia inducible factor-1α (HIF-1α) gene expression was upregulated, relative to that in the control. Compared with that in the control, at 4 and 6 weeks, the ratio of CTGF+ cells were significantly lower in the ESWT group; at 4 weeks, the ESWT group had significantly fewer CD68+ cells in the adhesion area, and at 6 weeks, significantly more blood vessels. This article is protected by copyright. All rights reserved.
Destructive Spondyloarthropathy due to Congenital Insensitivity to Pain with Anhidrosis: A Case Report of Long-Term Follow-Up.

Ko Hashimoto, Kohei Takahashi, Takahiro Onoki, Haruo Kanno, Naoki Morozumi, Shin Yamazaki, Ken-Ichiro Yahata, Toshimi Aizawa

The Tohoku journal of experimental medicine　258　(2)　91-95　2022年8月26日

DOI： 10.1620/tjem.2022.J060 　

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Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal-recessive hereditary neuropathy causing congenital loss of pain sensation, thermoception, and perspiration. CIPA sometimes causes destructive spondyloarthropathy, the so-called Charcot spine, because of insensitivity to pain stimuli. Herein, we report a case of CIPA with severe spinal destruction treated by multiple spinal reconstructive surgeries and over 15 years of follow-up. A 15-year-old male patient who had been diagnosed with CIPA at the age of 17 months presented to his previous spine clinic with gait disturbance due to muscle weakness in his lower extremities. Imaging studies revealed that collapsed L3 and L4 vertebral bodies involved the spinal canal, and it was treated by L3-L4 instrumented posterior fusion. Fourteen years after surgery, the patient became unable to walk again due to spinal canal stenosis at the proximal fusion segment. An L2-L3 posterior interbody fusion alleviated his gait ability for 2 years; however, he became unable to stand again because of the collapsed fusion segment that caused severe lumbar kyphosis. Subsequently, a two-staged posterior and anterior fusion surgery from the lower thoracic spine to the pelvis was performed, and spinal fusion and neurological recovery were achieved 3 years after surgery. A kyphotic deformity in patients with CIPA-associated Charcot spine could be favorably treated by a long spinal fusion in combination with a reconstruction of an anterior spinal column. This case report provides a significant lesson for a treatment of CIPA-associated Charcot spine.
首下がり・腰曲がり治療の最前線-現状と今後の展望- 成人脊柱後彎症の病態における骨盤傾斜の重要性

小澤浩司, 鎌田久美, 関口雄介, 菅野晴夫, 高橋康平, 相澤俊峰

東日本整形災害外科学会雑誌　34　(3)　190-190　2022年8月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
外反型変形性膝関節症に対する遠位大腿骨骨切り術3例4膝の治療成績

有野敦司, 秋貴史, 上村雅之, 伊東健太郎, 阿部高久, 古口昌志, 佐藤宏陽, 藤盛理子, 相澤俊峰

東北膝関節研究会会誌　30　27-31　2022年7月
出版者・発行元：東北膝関節研究会
ISSN：0917-5164

eISSN：2433-5614

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症例1は46歳男で、30歳頃から右膝の外反変形と疼痛を自覚し、徐々に左膝痛も自覚するようになった。今回、両膝の疼痛が増悪し、手術目的で当科に紹介された。単純X線で両膝ともKL分類grade 4の外反型OAを呈しており、%MAは105%/70%、FTAは160°/168°、mLDFAは81°/82°であった。手術は初めに右膝へDFOを行い、1年後に左膝へDFOを施行した。術後アライメントの矯正目標を%MA 50%とし、矯正角が右13°、左8°のMedial biplane closed wedge osteotomyを行った。右は術後4.5ヵ月で骨癒合が得られ、左は術後9.5ヵ月で骨癒合が得られた。最終観察時の%MAは33%/40%、FTAは180°/178°、mLDFAは92°/91°であった。症例2は69歳女で、53歳時から左膝痛を自覚し、近医で保存療法を受けていたが痛みは改善しないため手術目的で当科に紹介された。KL分類grade 4の外反型OAを認め、%MAは104%、FTAは156°、mLDFAは74°であった。矯正角度15°としてDFOを施行し、術後3ヵ月で骨癒合が得られ、最終観察時の%MAは38%、FTAは178°、mLDFAは89°であった。症例3は60歳女で、56歳時から右膝痛を自覚し、徐々に増悪したため手術目的で当科に紹介された。KL分類grade 3の外反型OAを認め、%MAは61%、FTAは168°、mLDFAは83°であった。矯正角度8°としてDFOを施行し、最終観察時の%MAは25%、FTAは180°、mLDFAは91°であった。
Foraminal Stenosis at L5-S1 as an Overlooked Pathology of Bilateral Radiculopathy: A Case Series. 国際誌

Kohei Takahashi, Ajay Kumar Yadav, Ko Hashimoto, Takumi Tsubakino, Toshimi Aizawa, Yasuhisa Tanaka

Journal of orthopaedic case reports　12　(6)　13-18　2022年6月

DOI： 10.13107/jocr.2022.v12.i06.2846 　

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INTRODUCTION: The classical symptom of foraminal stenosis is unilateral radiculopathy. Bilateral radiculopathy caused purely by foraminal stenosis is rare. Here, we report five cases of bilateral L5 radiculopathy caused purely by L5-S1 foraminal stenosis and describe the clinical and radiological features of these patients in detail. CASE PRESENTATION: Among the five patients, two were men and three were women with an average age of 69 years. Four patients had undergone surgeries at L4-5 level, previously. All the patients showed an improvement in symptoms in the post-operative period. After a certain period, the patients complained of bilateral leg pain and numbness. An additional surgery was performed in two patients; however, there was no improvement in symptoms. One patient, who did not undergo surgery, was treated conservatively for 3 years. All the patients had been suffering from bilateral leg symptoms before their first visit to our hospital. The neurological findings in these patients were consistent with bilateral L5 radiculopathy. The average pre-operative Japanese Orthopedic Association (JOA) score was 13 out of 29 points. Bilateral foraminal stenosis at L5-S1 level was confirmed using a three-dimensional magnetic resonance imaging or computed tomography. Posterior lumbar interbody fusion was performed in one patient and bilateral lateral fenestration using Wiltse's approach was performed in four patients. The neurological symptoms recovered immediately after surgery. The average JOA score at 2-year follow-up was 25 points. CONCLUSIONS: Spine surgeons may overlook the pathology of foraminal stenosis, particularly in patients with bilateral radiculopathy. Familiarity with the clinical and radiological features of symptomatic lumbar foraminal stenosis is necessary to properly diagnose bilateral foraminal stenosis at L5-S1 level.
「若年に見られる膝外傷後変形性膝関節症のマネジメント」 ACL再建術後に生じるOA変化の実態 KOACADを用いた定量評価

秋貴史, 上村雅之, 伊東健太郎, 阿部高久, 古口昌志, 佐藤宏陽, 藤盛理子, 井樋栄二, 相澤俊峰, 曽木靖仁

東北整形災害外科学会雑誌　65　(1)　173-174　2022年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
硬膜内髄外腫瘍における神経鞘腫と髄膜腫のMRI鑑別アルゴリズムの有効性

村上大史, 半田恭一, 大野木孝嘉, 鈴木学, 高橋康平, 小野田祥人, 矢部裕, 橋本功, 小澤浩司, 相澤俊峰

東北整形災害外科学会雑誌　65　(1)　258-258　2022年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
Post-laminectomy cervical flexion myelopathy and its possible pathomechanism: A case report.

Kohei Takahashi, Shinji Ogawa, Shuji Isefuku, Ko Hashimoto, Toshimi Aizawa

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2022年5月24日

DOI： 10.1016/j.jos.2022.05.002 　
Innovation of Surgical Techniques for Screw Fixation in Patients with Osteoporotic Spine. 国際誌

Haruo Kanno, Yoshito Onoda, Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa

Journal of clinical medicine　11　(9)　2022年5月4日

DOI： 10.3390/jcm11092577 　

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Osteoporosis is a common disease in elderly populations and is a major public health problem worldwide. It is not uncommon for spine surgeons to perform spinal instrumented fusion surgeries for osteoporotic patients. However, in patients with severe osteoporosis, instrumented fusion may result in screw loosening, implant failure or nonunion because of a poor bone quality and decreased pedicle screw stability as well as increased graft subsidence risk. In addition, revision surgeries to correct failed instrumentation are becoming increasingly common in patients with osteoporosis. Therefore, techniques to enhance the fixation of pedicle screws are required in spinal surgeries for osteoporotic patients. To date, various instrumentation methods, such as a supplemental hook, sublaminar taping and sacral alar iliac screws, and modified screwing techniques have been available for reinforcing pedicle screw fixation. In addition, several materials, including polymethylmethacrylate and hydroxyapatite stick/granules, for insertion into prepared screw holes, can be used to enhance screw fixation. Many biomechanical tests support the effectiveness of these augmentation methods. We herein review the current therapeutic strategies for screw fixation and augmentation methods in the surgical treatment of patients with an osteoporotic spine.
The psoas major muscle is essential for bipedal walking - An analysis using a novel upright bipedal-walking android model. 国際誌

Kouji Sanaka, Ko Hashimoto, Daisuke Kurosawa, Eiichi Murakami, Hiroshi Ozawa, Kohei Takahashi, Takahiro Onoki, Toshimi Aizawa

Gait & posture　94　15-18　2022年5月

DOI： 10.1016/j.gaitpost.2022.02.018 　

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BACKGROUND: Bipedalism is a unique function in humans. Various investigations in bipedal walking have assessed the kinetic chain from the pelvis to the lower limbs. However, few studies have investigated the functions of the upper body including the psoas major muscles. In the present study, a bipedal-walking human full-body skeletal model, "the bipedal android model", was generated by attaching air cylinder devices to simulate the contraction and relaxation of various muscles required for bipedal walking, including the psoas major muscles. The bipedal-walking principle was discussed using the model. METHODS: Every part of a human full-body skeletal model was connected by wires or cables to retain the mobility of each joint. Then the psoas major (PM), gluteus minimus (GM), long head of biceps femoris (BF), quadriceps femoris (QF), and semimembranosus (SM) muscles were simulated in the skeletal model using air cylinders. The gait pattern was observed by synchronizing the contraction of PM, GM, QF and SM, and relaxation of BF of the ipsilateral side together with the reversed patterns in the contralateral side, and then switching the phase by every step. The gait pattern in dysfunction of PM or GM muscles was also observed by disconnecting the corresponding air cylinders. RESULTS: The synchronized contraction of PM, GM, QF and SM generates the force to tilt the upper body to ipsilateral side, followed by elevation of the lower limb together with the forward rotation of the pelvis in the contralateral side to swing the leg forward. The next step was generated by reversing the contraction phase at the landing of the swung leg. The dysfunction of PM muscle disabled effective gait in the model, while GM did not. SIGNIFICANCE: The bipedal android model indicated that the psoas major muscles play a crucial role in bipedal walking in human.
Reinforcement of Percutaneous Pedicle Screw Fixation with Hydroxyapatite Granules in Patients with Osteoporotic Spine: Biomechanical Performance and Clinical Outcomes. 国際誌

Haruo Kanno, Yoshito Onoda, Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa

Medicina (Kaunas, Lithuania)　58　(5)　2022年4月23日

DOI： 10.3390/medicina58050579 　

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In percutaneous pedicle screw (PPS) fixation of the osteoporotic spine, rigid screw fixation obtaining strong stabilization is important for achieving successful treatment outcomes. However, in patients with severe osteoporosis, it is difficult to obtain PPS fixation with sufficient stability. PPS fixation has potential disadvantages with respect to maintaining secure stabilization in comparison to conventional pedicle screw fixation. In PPS fixation, bone grafting to achieve posterior spine fusion is generally not applicable and transverse connectors between the rods cannot be used to reinforce the fixation. Various augmentation methods, including additional hooks, sublaminar bands, and hydroxyapatite (HA) sticks, are available for conventional pedicle screw fixation. On the other hand, there has been no established augmentation method for PPS fixation. Recently, we developed a novel augmentation technique for PPS fixation using HA granules. This technique allows the percutaneous insertion of HA granules into the screw hole along the guidewire prior to insertion of the PPS. We have used this augmentation technique for PPS fixation in various spine surgeries in patients with osteoporosis. In our previous studies, biomechanical analyses demonstrated that PPS fixation was significantly enhanced by augmentation with HA granules in the osteoporotic lumbar spine. Furthermore, augmentation with HA granules was considered to decrease the incidence of screw loosening and implant failure following PPS fixation in patients with osteoporotic spine. In this article, we describe the surgical procedures of the augmentation method using HA granules and summarize our data from the biomechanical analysis of augmentation for PPS fixation. We also review the surgical outcomes of PPS fixation with augmentation using HA granules.
Clinical outcome of porous hydroxyapatite/collagen graft on bone defects following curettage of bone tumors. 国際誌

Jun Iwatsu, Munenori Watanuki, Shinichirou Yoshida, Shin Hitachi, Mika Watanabe, Toshimi Aizawa

Journal of biomedical materials research. Part B, Applied biomaterials　110　(10)　2211-2216　2022年4月19日

DOI： 10.1002/jbm.b.35070 　

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Hydroxyapatite/collagen (HAp/col) has been reported to be a highly useful bone-like nanocomposite. This study included 33 human patients to investigate the details of the clinical outcomes, which are (1) onset of timing of bone regeneration, (2) replacement by regenerated bone of HAp/col and (3) complications, in human cases grafting HAp/col in large bone defects, following curettage of bone tumors. Porous HAp/col initiated bone regeneration approximately 59 days following the surgery. In 15 cases (45%), complete replacement by newly formed bone was observed 12 months after surgery. On the other hand, incomplete replacement of HAp/col at the final follow-up was observed in 13 cases (39%). In these cases, HAp/col could not be detected in the transparent area of postoperative plain radiographs owing to quick absorption; moreover, it was difficult to distinguish whether the transparent area in plain radiographs was remaining HAp/col, recurrence, or remaining tumor. In addition, larger HAp/col implantation volume (≧15 cm3 ) was associated with poorer result of complete replacement (log-rank, p = .005). Further studies are warranted for the construction of a new artificial bone graft substitute that is more quickly and surely regenerated by newly formed bone in large bone defects.
Chaperone-Mediated Autophagy in Neurodegenerative Diseases and Acute Neurological Insults in the Central Nervous System. 国際誌

Haruo Kanno, Kyoichi Handa, Taishi Murakami, Toshimi Aizawa, Hiroshi Ozawa

Cells　11　(7)　2022年4月2日

DOI： 10.3390/cells11071205 　

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Autophagy is an important function that mediates the degradation of intracellular proteins and organelles. Chaperone-mediated autophagy (CMA) degrades selected proteins and has a crucial role in cellular proteostasis under various physiological and pathological conditions. CMA dysfunction leads to the accumulation of toxic protein aggregates in the central nervous system (CNS) and is involved in the pathogenic process of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Previous studies have suggested that the activation of CMA to degrade aberrant proteins can provide a neuroprotective effect in the CNS. Recent studies have shown that CMA activity is upregulated in damaged neural tissue following acute neurological insults, such as cerebral infarction, traumatic brain injury, and spinal cord injury. It has been also suggested that various protein degradation mechanisms are important for removing toxic aberrant proteins associated with secondary damage after acute neurological insults in the CNS. Therefore, enhancing the CMA pathway may induce neuroprotective effects not only in neurogenerative diseases but also in acute neurological insults. We herein review current knowledge concerning the biological mechanisms involved in CMA and highlight the role of CMA in neurodegenerative diseases and acute neurological insults. We also discuss the possibility of developing CMA-targeted therapeutic strategies for effective treatments.
Lumbar radiculopathy due to Bertolotti's syndrome: Alternative method to reveal the "hidden zone" - A report of two cases and review of literature.

Shigeaki Kojo, Kohei Takahashi, Takumi Tsubakino, Ko Hashimoto, Toshimi Aizawa, Yasuhisa Tanaka

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2022年3月16日

DOI： 10.1016/j.jos.2022.02.004 　
人工股関節置換術の術中関節可動域と術後の靴下の着脱・爪切り動作の満足度についての検討

田中秀達, 山田則一, 栗島宏明, 坂本敬, 森優, 大沼正宏, 大山正瑞, 相澤俊峰, 北純

日本整形外科学会雑誌　96　(3)　S565-S565　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
反復性肩関節前方脱臼に合併する関節窩骨欠損各骨欠損型の特徴

藍澤一穂, 山本宣幸, 川上純, 木村礼, 品川清嗣, 永元英明, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　96　(2)　S243-S243　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
股関節内旋制動における外旋筋や後方関節包の機能が、股関節屈曲角度で異なるか Cadaverを用いた研究

馬場一慈, 千葉大介, 森優, 桑原功行, 小暮敦史, 菅谷岳広, 鈴木貴之, 栗島宏明, 浜田壮志, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S805-S805　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
脊椎後彎症患者の歩行時と立位時の股関節肢位三次元動作解析装置を用いた歩行解析とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S754-S754　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
脊椎矢状面アライメントと股関節矢状面アライメントの関係

馬場一慈, 高橋康平, 石川圭佑, 藤田涼, 秋貴史, 大野木孝嘉, 橋本功, 関口雄介, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(2)　S193-S193　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
脊椎後彎症患者の歩行時と立位時の股関節肢位三次元動作解析装置を用いた歩行解析とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S754-S754　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
前額断MRIによる腰椎椎間孔部狭窄の診断の信頼性と再現性 T1・T2強調画像の信頼性・再現性の比較

橋本功, 田中靖久, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 古泉豊, 国分正一, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S762-S762　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の除圧効果に関連する因子の検討

高橋康平, 橋本功, 大野木孝嘉, 菅野晴夫, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S1046-S1046　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
術前MRIによるEden分類2型と3型の脊髄砂時計腫の鑑別

木村礼, 橋本功, 大野木孝嘉, 高橋康平, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S1135-S1135　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
視距離と頭部傾斜角による脊柱矢状面アライメントの推定情報端末作業時のメガネ装着型姿勢モニタリング装置開発にむけて

橋本功, 高橋佑生, 高橋康平, 大野木孝嘉, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S1183-S1183　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
メタローシスに対して二期的に人工膝関節再置換術を行った関節リウマチの一例

古山和樹, 森優, 上村雅之, 相澤俊峰

日本リウマチ学会北海道・東北支部学術集会抄録集　31回　56-56　2022年1月
出版者・発行元： (一社)日本リウマチ学会-北海道・東北支部
Evaluation of the usefulness of the Synovasure alpha-defensin lateral flow test kit for the diagnosis of periprosthetic joint infection in Japanese patients

Yu Mori, Ryuichi Kanabuchi, Kazayoshi Baba, Daisuke Chiba, Masayuki Kamimura, Naoko Mori, Toshimi Aizawa

Journal of Orthopaedic Science　27　(4)　935-938　2022年

DOI： 10.1016/j.jos.2022.05.001 　

ISSN：0949-2658

eISSN：1436-2023
Adolescent-onset Local Kyphosis with Anterior Column Hypoplasia and Subluxation of the Facet Joints of the Lumbar Spine: A Case Report. 国際誌

Kohei Takahashi, Ko Hashimoto, Takahiro Onoki, Kyoichi Handa, Haruo Kanno, Toshimi Aizawa

Journal of orthopaedic case reports　12　(1)　50-53　2022年1月

DOI： 10.13107/jocr.2022.v12.i01.2614 　

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Introduction: Hypoplasia of the anterior portion of the vertebral body is a relatively rare subtype of juvenile vertebral deformity. The common manifestations of this type of deformity are scoliosis and kyphoscoliosis, while kyphosis without scoliosis is rare. Here, we present a very rare case of adolescent-onset local kyphosis with anterior column hypoplasia and subluxation of the facet joints of the lumbar spine, as demonstrated by dynamic lateral radiograms, which was successfully treated by spine-shortening osteotomy. Case Report: A 16-year-old male adolescent presented with low back pain with progressive protrusion of the lumbar spinous process 3 years before the first visit. The protrusion was not found in his back until the age of 13 years. His chief complaint was lower back pain and a protruding spinous process in the upper lumbar spine. The anteroposterior radiogram of the whole spine revealed no obvious scoliosis. The lateral radiogram showed hypoplasia of the anterior portion of the L2 vertebral body with local kyphosis at L1-3 of 23°. The global alignment was posteriorly shifted, with hypokyphosis of the thoracic spine and hyperlordosis of the lower lumbar spine. In the dynamic lateral radiograms, the facet joints at the L2-3 spinal level were subluxated in the flexed position. Computed tomography showed symmetrical hypoplasia of the anterior portion of the vertebral body of L2. Spine-shortening osteotomy at L2 and L1-3 posterior fusion was performed for local stabilization and correction of sagittal malalignment. The lateral radiogram at the 2-year post-operative follow-up demonstrated that the global alignment was normal, with local kyphosis at L1-3 of -2°. The improvement of hypokyphosis of the thoracic spine and hyperlordosis of the lower lumbar spine was achieved. Conclusions: Adolescent-onset local lumbar kyphosis with anterior column hypoplasia and segmental subluxation of the facet joints is very rare. Local correction by spine-shortening osteotomy with short fusion can also improve the global alignment.
Imaging diagnosis of lumbar foraminal stenosis in the fifth lumbar nerve root: reliability and reproducibility of T1-weighted three-dimensional lumbar MRI. 国際誌

Ko Hashimoto, Yasuhisa Tanaka, Takumi Tsubakino, Takeshi Hoshikawa, Tomowaki Nakagawa, Takashi Inawashiro, Kohei Takahashi, Masaru Suda, Toshimi Aizawa

Journal of spine surgery (Hong Kong)　7　(4)　502-509　2021年12月

DOI： 10.21037/jss-21-63 　

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BACKGROUND: Various magnetic resonance imaging (MRI) techniques have been reported in detection of lumbar foraminal stenosis (LFS), especially for T2-weighted three-dimensional MRI (3D-MRI) describing the shape of nerve roots. The detection of LFS in the fifth lumbar nerve root (L5 root), however, is still less reliable compared to other lumbar nerve roots. Then we have been using T1-weighted 3D-MRI aiming to depict the shape of, and also pathology affecting the L5 root. The aim of this study is to evaluate our T1-weighted 3D-MRI in diagnosing LFS of the L5 root. METHODS: This retrospective study included 24 patients with intracanal stenosis (ICS) at L4-5, and 30 patients with LFS at L5-S causing unilateral L5 root lesion. The pre-operative T1-weighted 3D-MRI aiming bilateral L5 nerve roots of each patient were blinded and reviewed twice by five spine surgeons, independently. The image evaluation was performed in two conditions: (I) the symptomatic side was judged in 30 patients of LFS patients, and (II) the symptomatic side or the absence of LFS was judged in images of all the 54 patients including LFS and ICS patients. The correct-answer-rate, sensitivity and specificity of the imaging study were calculated. Also, the intra- and interobserver agreement of the imaging study by five spine surgeons were evaluated by the kappa (κ) statistics. RESULTS: For conditions (I) and (II) above, the mean correct-answer-rate was 92.3% and 69.8%, respectively. The sensitivity and specificity of the imaging study was 72.6% and 66.3%, respectively. The average of intraobserver κ-value of five examiners was 0.874 and 0.708, and the average of interobserver κ-value was 0.837 and 0.578, respectively. CONCLUSIONS: As well as previously reported T2-weighted 3D-MRI, our T1-weighted 3D-MRI was found to be reliable in diagnosing LFS of the L5 root.
Anterior decompression through a posterior approach for thoracic myelopathy caused by ossification of the posterior longitudinal ligament: a novel concept in anterior decompression and technical notes with the preliminary outcomes. 国際誌

Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa

Journal of neurosurgery. Spine　1-11　2021年9月24日

DOI： 10.3171/2021.4.SPINE213 　

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OBJECTIVE: Various surgical procedures are used to manage thoracic myelopathy due to ossification of the posterior longitudinal ligament (OPLL). However, the outcomes of surgery for thoracic OPLL are generally unfavorable in comparison to surgery for cervical OPLL. Previous studies have shown a significant risk of perioperative complications in surgery for thoracic OPLL. Thus, a safe and secure surgical method to ensure better neurological recovery with less perioperative complications is needed. The authors report a novel concept of anterior decompression through a posterior approach aimed at anterior shift of the OPLL during surgery rather than extirpation or size reduction of the OPLL. This surgical technique can securely achieve anterior shift of the OPLL using a curved drill, threadwire saw, and curved rongeur. The preliminary outcomes were investigated to evaluate the safety and efficacy of this technique. METHODS: This study included 10 consecutive patients who underwent surgery for thoracic OPLL. Surgical outcomes, including the ambulatory status, Japanese Orthopaedic Association (JOA) score, and perioperative complications, were investigated retrospectively. In this surgery, pedicle screws are introduced at least three levels above and below the corresponding levels. The laminae, facet joints, transverse processes, and pedicles are then removed bilaterally at levels wherein subsequent anterior decompression is performed. For anterior decompression, the OPLL and posterior portion of the vertebral bodies are partially resected using a high-speed drill with a curved burr, enabling the removal of osseous tissues just ventral to the spinal cord without retracting the dural sac. To securely shift the OPLL anteriorly, the intact PLL and posterior portion of the vertebral bodies cranial and caudal to the lesion are completely resected using a threadwire saw and/or curved rongeur. Rods are connected to the screws, and bone grafting is performed for posterolateral fusion. RESULTS: Five patients were nonambulatory before surgery, but all were able to walk at the final follow-up. The average JOA score before surgery and at the final follow-up was 3.2 and 8.8 points, respectively. Notably, the mean recovery rate of JOA score was 72%. Furthermore, no patients showed neurological deterioration postoperatively. CONCLUSIONS: The surgical technique is a useful alternative for safely achieving sufficient anterior decompression through a posterior approach and may consequently reduce the risk of postoperative neurological deterioration and improve surgical outcomes in patients with thoracic OPLL.
ビスフォスフォネートから治療変更したデノスマブの抗CCP抗体陽性関節リウマチ症例における骨関節破壊の抑制効果の検討

森優, 泉山拓也, 井樋栄二, 相澤俊峰

日本骨粗鬆症学会雑誌　7　(Suppl.1)　339-339　2021年9月
出版者・発行元： (一社)日本骨粗鬆症学会
ISSN：2189-8383
反復性肩関節前方脱臼に合併する関節窩骨欠損各骨欠損型の特徴

藍澤一穂, 山本宣幸, 川上純, 井樋栄二, 木村礼, 品川清嗣, 永元英明, 相澤俊峰

東日本整形災害外科学会雑誌　33　(3)　454-454　2021年8月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
低弾性率チタン合金製プレートによるウサギ脛骨骨切り部の骨癒合促進効果

伊東健太郎, 森優, 國井知典, 栗島宏明, 古口昌志, 藤盛理子, 正橋直哉, 花田修治, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　95　(8)　S1813-S1813　2021年8月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
筋・筋膜痛における好中球細胞外トラップの関与

鈴木一瑛, 土谷昌広, 神崎展, 吉田新一郎, 綿貫宗則, 矢部裕, 藤田涼, 高橋忠久, 萩原嘉廣, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　95　(8)　S1778-S1778　2021年8月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
胸腰椎緊急手術器械セットによる術前待機時間の短縮化

小野田祥人, 久志本成樹, 矢部裕, 橋本功, 相澤俊峰, 井樋栄二, 菅野晴夫

東北整形災害外科学会雑誌　64　(1)　189-189　2021年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
胸椎OPLLに対する彎曲型ドリルとT-sawを用いた新たな後方進入前方除圧安全・確実な除圧による手術成績の向上

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 高橋康平, 半田恭一, 井樋栄二

東北整形災害外科学会雑誌　64　(1)　193-193　2021年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
Mid- to Long-Term Outcomes After Resection of Thoracic Dumbbell Tumors Managed by Laminectomy and Unilateral Total Facetectomy Without Instrumented Fusion. 国際誌

Yuya Ishikawa, Masayuki Ohashi, Toru Hirano, Michiharu Matsuda, Takeru Akabane, Haruo Kanno, Ko Hashimoto, Kyoichi Handa, Toshimi Aizawa, Tomoto Suzuki, Yukihide Shimamura, Kei Watanabe

Global spine journal　21925682211008836-21925682211008836　2021年5月11日

DOI： 10.1177/21925682211008836 　

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STUDY DESIGN: Retrospective multicenter study. OBJECTIVE: To evaluate mid- to long-term surgical outcomes of thoracic dumbbell tumors managed by laminectomy and unilateral total facetectomy without instrumented fusion. METHODS: A total of 15 patients with thoracic dumbbell tumors who underwent primary resection by laminectomy and unilateral total facetectomy without spinal instrumented fusion between 2000 and 2015 were reviewed. Patient characteristics, surgical outcomes (including spinal alignment and stability), disc degeneration, pain, disability, and health-related quality of life were evaluated. Additionally, to analyze the impact of the affected levels on these outcomes, we divided the patients into 2 groups: a middle thoracic group and a thoracolumbar group. RESULTS: The mean duration of follow-up was 100.5 months (range, 36-190 months). The affected level was T3-T4 or below in all patients. Although the local kyphosis angle (8.1° to 12.7°), thoracic kyphosis angle (25.6° to 33.9°), and coronal Cobb angle (6.6° to 9.5°) significantly increased from preoperative to the final visit (P ≤ .02), no patient demonstrated spinal instability. From magnetic resonance imaging, no patient had a worse grade of disc degeneration in the affected level than those in the adjacent levels. The percentage of patients who presented with an Oswestry disability index ≤ 22% was 80%. Moreover, the surgical region did not adversely affect the outcomes. No patient required additional surgery due to spinal instability or deformity. CONCLUSIONS: Unilateral total facetectomy without fusion to resect thoracic dumbbell tumors caused neither spinal deformity nor instability requiring additional surgery at the mid- to long-term follow-up.
Randomized trial of granulocyte colony-stimulating factor for spinal cord injury. 国際誌

Masao Koda, Hideki Hanaoka, Yasuhisa Fujii, Michiko Hanawa, Yohei Kawasaki, Yoshihito Ozawa, Tadami Fujiwara, Takeo Furuya, Yasushi Ijima, Junya Saito, Mitsuhiro Kitamura, Takuya Miyamoto, Seiji Ohtori, Yukei Matsumoto, Tetsuya Abe, Hiroshi Takahashi, Kei Watanabe, Toru Hirano, Masayuki Ohashi, Hirokazu Shoji, Tatsuki Mizouchi, Norio Kawahara, Masahito Kawaguchi, Yugo Orita, Takeshi Sasamoto, Masahito Yoshioka, Masafumi Fujii, Katsutaka Yonezawa, Daisuke Soma, Hiroshi Taneichi, Daisaku Takeuchi, Satoshi Inami, Hiroshi Moridaira, Haruki Ueda, Futoshi Asano, Yosuke Shibao, Ikuo Aita, Yosuke Takeuchi, Masaya Mimura, Jun Shimbo, Yukio Someya, Sumio Ikenoue, Hiroaki Sameda, Kan Takase, Yoshikazu Ikeda, Fumitake Nakajima, Mitsuhiro Hashimoto, Fumio Hasue, Takayuki Fujiyoshi, Koshiro Kamiya, Masahiko Watanabe, Hiroyuki Katoh, Yukihiro Matsuyama, Tomohiko Hasegawa, Go Yoshida, Hideyuki Arima, Yu Yamato, Shin Oe, Daisuke Togawa, Sho Kobayashi, Koji Akeda, Eiji Kawamoto, Hiroshi Imai, Toshihiko Sakakibara, Akihiro Sudo, Yasuo Ito, Takeshi Kikuchi, Tomoyuki Takigawa, Takuya Morita, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Shinji Kotaka, Hideo Baba, Tsuyoshi Okudaira, Hiroaki Konishi, Takayuki Yamaguchi, Keigo Ito, Yoshito Katayama, Taro Matsumoto, Tomohiro Matsumoto, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Toshimitsu Eto, Takehiro Sugaya, Michiharu Matsuda, Kazunari Fushimi, Satoshi Nozawa, Chizuo Iwai, Toshihiko Taguchi, Tsukasa Kanchiku, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Takashi Sakai, Yasuaki Imajo, Masashi Yamazaki

Brain : a journal of neurology　144　(3)　789-799　2021年4月12日

DOI： 10.1093/brain/awaa466 　

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Attenuation of the secondary injury of spinal cord injury (SCI) can suppress the spread of spinal cord tissue damage, possibly resulting in spinal cord sparing that can improve functional prognoses. Granulocyte colony-stimulating factor (G-CSF) is a haematological cytokine commonly used to treat neutropenia. Previous reports have shown that G-CSF promotes functional recovery in rodent models of SCI. Based on preclinical results, we conducted early phase clinical trials, showing safety/feasibility and suggestive efficacy. These lines of evidence demonstrate that G-CSF might have therapeutic benefits for acute SCI in humans. To confirm this efficacy and to obtain strong evidence for pharmaceutical approval of G-CSF therapy for SCI, we conducted a phase 3 clinical trial designed as a prospective, randomized, double-blinded and placebo-controlled comparative trial. The current trial included cervical SCI [severity of American Spinal Injury Association (ASIA) Impairment Scale (AIS) B or C] within 48 h after injury. Patients are randomly assigned to G-CSF and placebo groups. The G-CSF group was administered 400 μg/m2/day × 5 days of G-CSF in normal saline via intravenous infusion for five consecutive days. The placebo group was similarly administered a placebo. Allocation was concealed between blinded evaluators of efficacy/safety and those for laboratory data, as G-CSF markedly increases white blood cell counts that can reveal patient treatment. Efficacy and safety were evaluated by blinded observer. Our primary end point was changes in ASIA motor scores from baseline to 3 months after drug administration. Each group includes 44 patients (88 total patients). Our protocol was approved by the Pharmaceuticals and Medical Device Agency in Japan and this trial is funded by the Center for Clinical Trials, Japan Medical Association. There was no significant difference in the primary end point between the G-CSF and the placebo control groups. In contrast, one of the secondary end points showed that the ASIA motor score 6 months (P = 0.062) and 1 year (P = 0.073) after drug administration tend to be higher in the G-CSF group compared with the placebo control group. Moreover, in patients aged over 65 years old, motor recovery 6 months after drug administration showed a strong trend towards a better recovery in the G-CSF treated group (P = 0.056) compared with the control group. The present trial failed to show a significant effect of G-CSF in primary end point although the subanalyses of the present trial suggested potential G-CSF benefits for specific population.
A Right Angle Guide for Distal Tuberosity Osteotomy With Medial Open Wedge High Tibial Osteotomy for Varus Knee Osteoarthritis. 国際誌

Akira Sasaki, Takehiko Sugita, Nobuyuki Itaya, Toshimi Aizawa, Naohisa Miyatake, Seiya Miyamoto, Ikuo Maeda, Masayuki Kamimura, Atsushi Takahashi, Hideaki Nagamoto

Arthroscopy techniques　10　(4)　e1007-e1016　2021年4月

DOI： 10.1016/j.eats.2020.11.017 　

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Medial open wedge high tibial osteotomy (OWHTO) is usually performed with proximal tuberosity osteotomy or setting the osteotomy line proximal to the tuberosity. However, OWHTO can result in patellofemoral complications due to postoperative patella infera. A new OWHTO technique, biplanar osteotomy with a distal tuberosity osteotomy, was reported in 2004 to prevent postoperative patella infera. To ensure that the 2 osteotomy lines maintain perpendicular, we describe the OWHTO procedure with a distal tuberosity osteotomy technique using a TriS Medial HTO Plate System (Olympus Terumo Biomaterials Corp., Tokyo, Japan) and a right angle guide we developed. In this Technical Note, we describe the procedure and advantages, risks, and limitations, as well as the pearls and pitfalls based on our experience.
胸椎後縦靱帯骨化症に対する後方進入前方除圧術(大塚変法)の手術成績とCTによる除圧の検証

高橋康平, 相澤俊峰, 橋本功, 小野田祥人, 半田恭一, 大野木孝嘉, 菅野晴夫, 小澤浩司

Journal of Spine Research　12　(3)　96-96　2021年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
胸椎OPLLに対する彎曲型ドリルとT-sawを用いた新たな後方進入前方除圧安全・確実な除圧が術後の麻痺悪化を回避し早期離床を可能にする

菅野晴夫, 相澤俊峰, 橋本功, 高橋康平, 半田恭一, 井樋栄二, 小澤浩司

Journal of Spine Research　12　(3)　179-179　2021年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
前額断MRIによる腰椎椎間孔部狭窄の診断 T1・T2強調画像の信頼性・再現性と読影傾向の比較検証

橋本功, 田中靖久, 相澤俊峰, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 両角直樹, 古泉豊, 佐藤哲朗, 小澤浩司, 菅野晴夫, 国分正一, 井樋栄二

Journal of Spine Research　12　(3)　359-359　2021年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
成人脊柱変形に対するdynamic compression hookを併用した脊柱短縮骨切り術変形矯正効果とロッド折損予防の検討

菅野晴夫, 相澤俊峰, 橋本功, 小澤浩司

Journal of Spine Research　12　(3)　394-394　2021年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
脊髄神経鞘腫摘出術における神経根切離後の神経脱落症状の検討

半田恭一, 相澤俊峰, 村上大史, 大野木孝嘉, 高橋康平, 橋本功, 小澤浩司, 井樋栄二

Journal of Spine Research　12　(3)　429-429　2021年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
硬膜内髄外腫瘍における神経鞘腫と髄膜腫のMRI鑑別アルゴリズムの有効性

村上大史, 相澤俊峰, 半田恭一, 大野木孝嘉, 鈴木学, 高橋康平, 小野田祥人, 橋本功, 小澤浩司, 井樋栄二

Journal of Spine Research　12　(3)　433-433　2021年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の成績後方除圧固定術との比較

相澤俊峰, 橋本功, 高橋康平, 大野木孝嘉, 半田恭一, 菅野晴夫, 小澤浩司

Journal of Spine Research　12　(3)　592-592　2021年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
脊椎手術における温風式加温装置の術中使用はSSI発生リスクか傾向スコアマッチング法を用いた検討

半田恭一, 菅野晴夫, 松谷重恒, 大野木孝嘉, 高橋康平, 橋本功, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　95　(3)　S705-S705　2021年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
前額断MRIによる腰椎椎間孔部狭窄の診断 T1・T2強調画像の信頼性・再現性と読影傾向の比較検証

橋本功, 田中靖久, 相澤俊峰, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 両角直樹, 古泉豊, 佐藤哲朗, 小澤浩司, 菅野晴夫, 国分正一, 井樋栄二

Journal of Spine Research　12　(3)　359-359　2021年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
Retrospective comparison of the surgical results for patients with thoracic myelopathy caused by ossification of the posterior longitudinal ligament: Posterior decompression with instrumented spinal fusion versus modified anterior decompression through a posterior approach.

Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Kyoichi Handa, Kohei Takahashi, Takahiro Onoki, Eiji Itoi, Hiroshi Ozawa

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　27　(2)　323-329　2021年2月7日

DOI： 10.1016/j.jos.2021.01.001 　

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BACKGROUND: In Japan, approximately 75% of patients with thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) are treated by posterior decompression with instrumented spinal fusion (PDF) because of its efficacy and safety. To achieve more effective decompression of the spinal cord using a posterior approach, anterior decompression through a posterior approach was developed. However, this technique has a high risk of postoperative paralysis. We have added a couple of ingenuities to this procedure (modified Ohtsuka procedure). This study was performed to report the surgical results of our modified Ohtsuka procedure and to compare them with the results of PDF. METHODS: This was a retrospective case series. From 2008 to 2018, we surgically treated 32 patients: 20 patients treated by PDF (PDF group) and 12 patients by our modified Ohtsuka procedure (modified Ohtsuka group) as the initial surgery. All patients were followed up for at least 12 months. The degree of surgical invasion and patients' neurological condition were assessed. RESULTS: The operative duration and intraoperative blood loss indicated no significant differences (PDF vs. Ohtuska: 507 ± 103 vs. 534 ± 99 min, 1022 ± 675 vs. 1160 ± 685 ml, respectively). The preoperative Japanese Orthopaedic Association (JOA) score was 4.5 ± 2.0 in the PDF group and 3.3 ± 1.4 in the modified Ohtsuka group (p < 0.05). However, the latest JOA score and recovery rate were significantly better in the modified Ohtsuka group than in the PDF group (8.9 ± 1.2 vs. 7.4 ± 2.5 and 70.8 ± 17.6% vs. 44.5 ± 40.2%, respectively). Postoperative paralysis did not occur in the modified Ohtsuka group while four patients had it in the PDF group. CONCLUSIONS: The present study clearly indicated the modified Ohtsuka group showed significantly better surgical outcomes than the PDF group with the recovery rate ≥70%.
Posterior osteotomy and reconstruction for osteoporotic vertebral collapse

Hiroshi Ozawa, Yasuhisa Tanaka, Toshimi Aizawa, Haruo Kanno, Shoichi Kokubun

Osteoporosis Of The Spine: Asian Perspectives　582-590　2021年1月19日
出版者・発行元： World Scientific Publishing Co.
DOI： 10.1142/9789811220814_0025 　
Surgical management of facet cysts in the thoracic spine: Radiological manifestations and results of fenestration

Takashi Kusakabe, Toshimi Aizawa, Fumio Kasama, Takeshi Nakamura, Akira Sekiguchi, Takeshi Hoshikawa, Yutaka Koizumi

Journal of Orthopaedic Science　2021年
出版者・発行元： Elsevier B.V.
DOI： 10.1016/j.jos.2021.07.007 　

ISSN：1436-2023 0949-2658
Surgical outcomes of patients with sacroiliac joint pain: An analysis of patients with poor results regarding activities of daily living

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa, Takashi Watanabe

Spine Surgery and Related Research　5　(3)　189-195　2021年
出版者・発行元： Japanese Society for Spine Surgery and Related Research
DOI： 10.22603/SSRR.2020-0214 　

ISSN：2432-261X
Novel augmentation technique of percutaneous pedicle screw fixation using hydroxyapatite granules in the osteoporotic lumbar spine: a cadaveric biomechanical analysis. 国際誌

Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　30　(1)　71-78　2021年1月

DOI： 10.1007/s00586-020-06451-2 　

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PURPOSE: Percutaneous pedicle screw (PPS) fixation has been commonly used for various spine surgeries. Rigid PPS fixation is necessary to decrease the incidence of screw loosening in osteoporotic spine. Recently, we have reported biomechanical advantages of augmentation technique using hydroxyapatite (HA) granules for PPS fixation in synthetic bone. However, its biomechanical performance in augmenting PPS fixation for osteoporotic spine has not been fully elucidated. The aim of the present study is to perform a cadaveric biomechanical analysis of PPS fixation augmented with HA granules. METHODS: Thirty osteoporotic lumbar vertebrae (L1-L5) were obtained from 6 cadavers (3 men and 3 women; age 80 ± 9 years; bone mineral density 73 ± 9 mg/cm3). The maximal pullout strength and maximal insertion torque were compared between the screws inserted into the vertebrae with and without augmentation. In toggle testing, the number of craniocaudal toggle cycles and maximal load required to achieve the 2-mm screw head displacement were also compared. RESULTS: The maximal pullout strength in the screws augmented with HA granules was significantly greater compared to those without augmentation (p < 0.05). The augmentation significantly increased the maximal insertion torque of the screws (p < 0.05). Moreover, the number of toggle cycles and the maximal load required to reach 2 mm of displacement were significantly higher in the augmented screws (p < 0.05). CONCLUSION: The PPS fixation was significantly enhanced by the augmentation with HA granules in the osteoporotic lumbar spine. The PPS fixation augmented with HA granules might decrease the incidence of screw loosening and implant failure in patients with osteoporotic spine.
Surgical results of nonambulatory patients caused by ossification of the posterior longitudinal ligaments in the thoracic spine: retrospective comparative study between posterior decompression and instrumented spinal fusion versus anterior decompression through a posterior approach. 国際誌

Toshimi Aizawa, Toshimitsu Eto, Ko Hashimoto, Haruo Kanno, Eiji Itoi, Hiroshi Ozawa

Journal of neurosurgery. Spine　34　(3)　1-6　2020年12月11日

DOI： 10.3171/2020.7.SPINE20411 　

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OBJECTIVE: Thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) remains one of the most difficult-to-treat disorders for spine surgeons. In Japan, approximately 75% of patients with this condition are treated using posterior decompression with instrumented spinal fusion (PDF). In contrast, anterior decompression is the most effective method for relieving spinal cord compression. The authors treated nonambulatory patients with thoracic OPLL by either PDF or by their technique using anterior decompression through a posterior approach. In this study the surgical results of these procedures are compared. METHODS: This was a retrospective case series. From 2008 to 2018, 9 patients with thoracic OPLL who could not walk preoperatively were treated surgically. Three patients were treated by PDF (the PDF group) and 6 patients were treated by anterior decompression through a posterior approach (the modified Ohtsuka group). The degree of surgical invasion and the neurological conditions of the patients were assessed. RESULTS: The PDF group had a shorter operative duration (mean 477 ± 122 vs 569 ± 92 minutes) and less intraoperative blood loss (mean 613 ± 380 vs 1180 ± 614 ml), although the differences were not statistically significant. The preoperative Japanese Orthopaedic Association (JOA) score was almost identical between the two groups; however, the latest JOA score and the recovery rate were significantly better in the modified Ohtsuka group than in the PDF group (8.8 ± 1.5 vs 5.0 ± 1.7 and 71.3% ± 23.7% vs 28.3% ± 5.7%, respectively). The walking ability was evaluated using the modified Frankel scale. According to this scale, 3 patients showed three grade improvements, 2 patients showed two grade improvements, and 1 patient showed one grade improvement in the modified Ohtsuka group. Three patients in the modified Ohtsuka group could walk without any support at the final follow-up. CONCLUSIONS: The present study clearly indicated that the surgical outcomes of the authors' modified Ohtsuka procedure were significantly better than those of PDF for patients who could not walk preoperatively.
Rate of spinal surgery in a rapidly aging society: the 27-year changes in Miyagi prefecture, Japan. 国際誌

Toshimi Aizawa, Shoichi Kokubun, Takashi Kusakabe, Hiroshi Ozawa, Yasuhisa Tanaka, Takeshi Hoshikawa, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yutaka Koizumi, Chikashi Kawahara, Tetsuro Sato, Hironori Hyodo, Shinji Ogawa, Eiichi Murakami, Eiji Itoi

Journal of neurosurgical sciences　64　(6)　525-530　2020年12月

DOI： 10.23736/S0390-5616.18.04251-0 　

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BACKGROUND: Japan has had a rapidly aging population during the past 30 years. This study aimed to investigate longitudinal changes in the surgical rate for spinal disorders in Miyagi Prefecture (2.35 million inhabitants) with a similar population composition to Japan. METHODS: Data of spinal surgeries were collected using the spine registry by Tohoku University Spine Society. Data on the annual number of spinal surgeries between 1988 and 2014 of all populations, in those aged ≥65 years old, in those aged ≥75 years old, and for each pathology were collected. The annual surgical rate per 100,000 inhabitants was calculated. RESULTS: The surgical rate in 2010-2014 in total, at ≥65 years old, and at ≥75 years old showed 3.2-, 3.8- and 7.1-fold increases, respectively, compared with that in 1988-1989. Degenerative spinal disorders, spinal trauma and pyogenic spondylitis markedly increased, while metastatic spinal tumor and tuberculous spondylitis decreased over time. The surgical rate at ≥75 years with lumbar spinal stenosis showed a 12.6-time increase. CONCLUSIONS: During a rapid period of aging, the rate of spinal surgeries has markedly increased, particularly, that for degenerative disorders. This is the first report on the long-term longitudinal changes in the rate of spinal surgery.
Anterior Decompression and Fusion Versus Laminoplasty for Cervical Myelopathy Caused by Soft Disk Herniation: A Long-term Prospective Multicenter Study. 国際誌

Tomoaki Koakutsu, Toshimi Aizawa, Morichika Sasaki, Akira Sekiguchi, Naoki Morozumi, Yushin Ishii, Shoichi Kokubun, Ko Hashimoto, Fumio Kasama, Yasuhisa Tanaka, Tetsuro Sato, Eiji Itoi, Shin Yamazaki

Clinical spine surgery　33　(10)　E478-E485　2020年12月

DOI： 10.1097/BSD.0000000000000986 　

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STUDY DESIGN: A prospective multicenter study. OBJECTIVE: The purpose of this study was to determine whether laminoplasty (LP) is comparable for myelopathy caused by cervical disk herniation (CDH). SUMMARY OF BACKGROUND DATA: Anterior decompression and fusion (ADF) has conventionally been used for myelopathy caused by CDH with stable outcomes. However, recurrence of myelopathy due to adjacent segment degeneration are its drawbacks. The efficacy of LP without discectomy has been sporadically reported, but no long-term prospective study has been conducted to verify it. MATERIALS AND METHODS: Patients with cervical myelopathy caused by CDH were studied. The first 30 patients and the next 30 patients were treated with ADF and LP, respectively. The outcomes were compared between the 22 ADF patients and the 20 LP patients who had completed the follow-up examination scheduled 10 years after surgery. RESULTS: There was no statistically significant difference in the postoperative severity or recovery rate of myelopathy between the 2 groups 10 years after surgery. One patient in the ADF group underwent LP for secondary myelopathy due to adjacent segment degeneration 2 years after the surgery. Reoperation was not required for patients in the LP group. Postoperative neck pain was significantly more severe in the LP group than in the ADF group. CONCLUSIONS: ADF and LP for cervical myelopathy caused by CDH achieve similarly favorable outcomes. Recurrence of myelopathy caused by adjacent segment degeneration is a disadvantage of ADF while residual neck pain is a disadvantage of LP.
Obesity is a risk factor for osteoarthritis progression and spontaneous osteoporosis is a risk for the development of spontaneous osteonecrosis in patients with medial meniscus posterior root tear.

Atsushi Takahashi, Jutaro Umehara, Masayuki Kamimura, Toshimi Aizawa, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2020年10月5日

DOI： 10.1016/j.jos.2020.09.001 　

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BACKGROUND: Obesity is a representative risk factor for osteoarthritis (OA). The relationship between osteoporosis and executed osteonecrosis has been reported. The primary aim of this study was to determine the influence of obesity and osteoporosis on disease progression in patients with medial meniscus posterior root tear (MMPRT). METHODS: We included 41 knees with MMPRT in this study. MMPRT was diagnosed based on the presence of both a meniscus ghost sign and a vertical linear defect on MRI. OA progression and development of osteonecrosis were evaluated using plain radiographs obtained at the initial visit and the final follow-up. The follow-up period for all knees was 30 ± 8 (mean ± standard deviation) months. Patients' physical attributes were assessed at initial visits; these attributes included body mass index (BMI) and the clinical risk for osteoporotic fracture, as determined by the World Health Organization fracture risk assessment tool (FRAX). Patients with a BMI ≥25 kg/m2 were classified in the obesity group and those with a BMI <25 kg/m2 in the control group. Patients with a FRAX score of ≥10% were classified in the high FRAX group and those with a FRAX score of <10% in the low FRAX group. RESULTS: OA progression evaluated by Kellgren-Lawrence grading scale was observed in 75% patients in the obesity group (1 grade in 38%, 2 grades in 31%, and 3 grades in 6%) and 58% in the control group (1 grade in 58%). Patients in the obesity group showed significantly greater OA progression. Spontaneous osteonecrosis was observed in no knees at the initial visit and six knees at the final follow-up. All six lesions were observed in the high FRAX group, which was statistically significant. CONCLUSIONS: OA progression and development of osteonecrosis were the two representative deterioration patterns in patients with MMPRT. High BMI was related with OA progression, and FRAX score of ≥10% with the development of osteonecrosis.
化膿性脊椎炎術後に非閉塞性腸管虚血症を発症した1例

佐藤宏陽, 相澤俊峰, 橋本功, 菅野晴夫, 衛藤俊光, 半田恭一, 井樋栄二

臨床整形外科　55　(10)　1177-1180　2020年10月
出版者・発行元： (株)医学書院
ISSN：0557-0433

eISSN：1882-1286
Criteria for Identifying Technically Difficult Cases when Performing Sacroiliac Intraarticular Injections Based on the Grade of Sacroiliac Arthrogram. 国際誌

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa, Takashi Watanabe, Yutaka Yabe

Pain medicine (Malden, Mass.)　21　(10)　2105-2110　2020年10月1日

DOI： 10.1093/pm/pnaa120 　

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OBJECTIVE: An intraarticular sacroiliac joint (SIJ) injection cannot always be performed successfully. Based on the patterns of the sacroiliac arthrogram, we explored possible indicators of technically difficult and technically easy injections into the SIJ including demographic features and anatomical features evident on preprocedural imaging. DESIGN: Observational study. METHODS: We evaluated 76 patients with painful SIJ (total 108 joints) diagnosed by SIJ injections. The sacroiliac arthrogram was graded as follows: Grade (G) 0 = the margin of the joint was partially outlined; G1 = the margin was completely outlined; G2 = intraarticular space was substantially outlined; and G3 = intraarticular space was fully outlined. Two multivariable ordered logistic regression analyses were performed to test the relationships between gender, age, and Grade, as well as between computed tomography (CT) findings and grade. RESULTS: In men, the totals by Grade were G0 = 8 (joints); G1 = 33; G2 = 3; and G3 = 0. In women, these were G0 = 4; G1 = 28; G2 = 22; and G3 = 10. The Grade was significantly higher in women and was also higher with age (P < 0.05). Regarding morphological features in CT, minor osteophytes increased the odds in favor of better Grades of arthrogram (odds ratio = 3.50). Substantial vacuum phenomena strongly increased the odds of better arthrograms (20.52). CONCLUSIONS: Outlining the SIJ cavity fully is significantly more difficult in male patients of any age than in aged female patients. The presence of minor osteophytes and substantial vacuum phenomena on preprocedure CT scans can be reasonably reassuring to the practitioner that they are unlikely to encounter difficulties during injection.
腰痛のない健常中高年者229名における腰椎不安定性

鈴木学, 田中靖久, 橋本功, 相澤俊峰, 椿野巧, 星川健, 高橋康平, 三宅公太, 小城繁明, 金城英傑, 井樋栄二

日本整形外科学会雑誌　94　(8)　S1910-S1910　2020年9月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
自然縮小した胸椎部砂時計腫の1例

鈴木学, 相澤俊峰, 橋本功, 菅野晴夫, 小野田祥人, 井樋栄二

東日本整形災害外科学会雑誌　32　(2)　198-201　2020年6月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の手術成績

相澤俊峰, 橋本功, 菅野晴夫, 半田恭一, 小野田祥人, 井樋栄二, 小澤浩司

Journal of Spine Research　11　(3)　217-217　2020年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の新たな工夫彎曲型ドリルとT-sawによる安全・確実な前方除圧

菅野晴夫, 相澤俊峰, 橋本功, 衛藤俊光, 井樋栄二

Journal of Spine Research　11　(3)　219-219　2020年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
固定術を併用しない胸椎砂時計腫摘出術の中長期成績多施設研究

石川裕也, 大橋正幸, 平野徹, 松田倫治, 赤羽武, 菅野晴夫, 橋本功, 半田恭一, 相澤俊峰, 鈴木智人, 嶋村之秀, 渡辺慶

Journal of Spine Research　11　(3)　517-517　2020年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
腰椎不安定性と腰痛の関連 189例の健常者による前向き研究

鈴木学, 田中靖久, 橋本功, 相澤俊峰, 椿野巧, 星川健, 高橋康平, 三宅公太, 小城繁明, 金城英傑, 井樋栄二

日本整形外科学会雑誌　94　(2)　S118-S118　2020年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
胸椎後縦靱帯骨化症の手術成績後方除圧固定術と後方進入前方除圧術の比較

相澤俊峰, 橋本功, 菅野晴夫, 衛藤俊光, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　94　(3)　S936-S936　2020年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
Spontaneous Resorption of Intradural Lumbar Disc Herniation: A Rare Case Report.

Naoki Morozumi, Toshimi Aizawa, Morichika Sasaki, Yutaka Koizumi, Shoichi Kokubun

Spine surgery and related research　4　(3)　277-279　2020年

DOI： 10.22603/ssrr.2019-0074 　
Accurate and Minimally Invasive Cervical Pedicle Screw Insertion Procedure Using the Bone Biopsy Needle as Drill Guide.

Tomoaki Koakutsu, Toshimi Aizawa, Eiji Itoi

Spine surgery and related research　4　(4)　358-364　2020年

DOI： 10.22603/ssrr.2019-0114 　

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Introduction: Cervical pedicle screw (CPS) fixation provides the strongest mechanical stability. It needs, however, wide soft tissue detachment to expose the entry point and carries the potential risk of iatrogenic damage to neurovascular structures. Malposition of the CPS cannot be completely avoided even using the navigation system. Technical Note: Using the bone biopsy needle as drill guide, we developed a novel accurate CPS insertion technique. (1) The entry point of CPS was exposed using Southwick's technique for anterior fixation or Tokioka's technique for posterior fixation. (2) A 13G bone biopsy needle was inserted from the entry point established by the fluoroscopy-assisted pedicle axis view technique described by Yukawa et al. to within a few millimeters of the pedicle. (3) The external sleeve of the bone biopsy needle was left in place as a drill guide, and the 1.25 mm guidewire for a 4.0 mm cannulated screw was then inserted into the pedicle cavity. (4) The external sleeve of the bone biopsy needle was removed, and the screw trajectory was created by a 2.7 mm cannulated drill bit over the guidewire. (5) Tapping was conducted prior to CPS insertion. Using this method, 29 CPSs in nine patients were inserted. Postoperative computed tomography scans revealed that all the CPSs were placed accurately. Conclusions: Utilizing the bone biopsy needle as drill guide, our procedure enables accurate positioning of CPS without expensive instruments.
Quality of life after staged bilateral total knee arthroplasty: a minimum five-year follow-up study of seventy-eight patients. 国際誌査読有り

Takehiko Sugita, Naohisa Miyatake, Toshimi Aizawa, Akira Sasaki, Masayuki Kamimura, Atsushi Takahashi

International orthopaedics　43　(10)　2309-2314　2019年10月

DOI： 10.1007/s00264-018-4196-0 　

ISSN：0341-2695

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PURPOSE: Although many studies have been performed to evaluate the quality of life (QOL) and patient satisfaction after total knee arthroplasty (TKA), almost all evaluations were performed in patients after unilateral TKA or in patients after mixed unilateral and bilateral TKA. Accordingly, this study aimed to evaluate QOL after staged bilateral TKA. METHODS: A total of 78 patients who underwent staged bilateral TKA for varus knee osteoarthritis were included in this study. All patients had longitudinal follow-up evaluations for at least five years. QOL was assessed by the Japanese Knee Osteoarthritis Measure (JKOM), a disease-specific and patient-derived QOL measure for Japanese patients. Conventional objective outcome scales, including the Knee Society Score and the Timed Up and Go test, were also assessed. In addition, QOL and objective outcomes were compared between the younger (≤ 80 years, average 75.8 years) and older (> 80 years, average 84.7 years) age groups at the final follow-up. RESULTS: Improvements in both JKOM and objective outcomes reached a plateau one year after staged bilateral TKA. Improvements were prolonged for more than five years. There were no statistically significant differences in JKOM or objective outcomes between the younger and older age groups, despite an 8.9-year difference in the average age. CONCLUSIONS: This was the first longitudinal study to evaluate QOL and objective outcomes after staged bilateral TKA for a period of at least five years. Improvements in QOL and objective outcomes reached a plateau one year after staged bilateral TKA and were prolonged for more than five years. No significant differences were observed in outcome scores between the younger and older age groups.
Several pathologies cause delayed postoperative paralysis following posterior decompression and spinal fusion for thoracic myelopathy caused by ossification of the posterior longitudinal ligament. 査読有り

Toshimitsu Eto, Toshimi Aizawa, Haruo Kanno, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　27　(3)　725-733　2019年9月12日

DOI： 10.1016/j.jos.2019.08.004 　

ISSN：0949-2658
Spino-pelvic- lower extremity balance during walking in elderly patients with spinal kyphosis. 査読有り

Kumi Kamata, Hiroshi Ozawa, Yusuke Sekiguchi, Toshimi Aizawa, Shinichi Izumi, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　24　(5)　793-797　2019年9月

DOI： 10.1016/j.jos.2019.01.005 　

ISSN：0949-2658

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BACK GROUND: Patients with spinal kyphosis were radiographically evaluated while standing. However, the spino-pelvic alignment during walking is different. This study examined the spino-pelvic-lower extremity alignment during walking by a three-dimensional (3D) motion analysis. METHODS: Twenty-six patients with a sagittal vertical axis of ≥4 cm (male: female, 5:21; average age, 66 years) were evaluated. Using a 3D motion capture system, the trunk and pelvic anterior inclination angles, hip and knee joint angles were measured during a 3-min walk. The correlation coefficient between the change of the trunk anterior inclination angle and each parameter at the beginning of walking was calculated, and those parameters were compared with radiographic measurements. RESULTS: The patients were divided into two groups according to the change of the trunk anterior inclination angle: the large change group included 14 patients with an increase of ≥5° between the beginning and end of the 3-min walk; the small change group included 12 patients with an increase of <5°. The pelvic anterior inclination angle showed a significant difference between the two groups at the first gait cycles. The pelvic anterior inclination angle and the hip joint angle in the large change group showed a significant difference between the first and last cycles. The correlation coefficient revealed a significant association between the change in the trunk anterior inclination angle and the pelvic anterior inclination angle at the beginning of walking. There were no significant differences between the two groups in any radiographic spino-pelvic parameters. CONCLUSIONS: There were two types of patients with spinal kyphosis: patients with a small pelvic anterior inclination angle at the beginning of walking showed slight progression in their trunk anterior inclination, whereas those with a large pelvic angle showed a large degree of progression in their pelvic and trunk inclination during walking.
Surgical Management of Giant Sacral Schwannoma: A Case Series and Literature Review. 国際誌査読有り

Kyoichi Handa, Hiroshi Ozawa, Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Satoshi Tateda, Eiji Itoi

World neurosurgery　129　e216-e223-e223　2019年9月

DOI： 10.1016/j.wneu.2019.05.113 　

ISSN：1878-8750

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OBJECTIVE: Giant sacral schwannomas are rare and difficult to treat. Unexpected neurologic deficits after surgery and tumor recurrence should be considered when surgery is performed. We attempt to remove the tumors via piecemeal total or subtotal excision, leaving parts of the capsule adjacent to nerves to preserve the nerves. This study aimed to present the cases of giant sacral schwannoma at our institutions as well as review the relevant literature and to discuss surgical management. METHODS: This study included 11 patients (5 male and 6 female, mean age 53 years) with giant sacral schwannoma who were treated surgically. The clinical features, surgical details, and outcomes were investigated retrospectively. RESULTS: The tumors were intraosseous type in 4 cases, dumb-bell type in 3 cases, and retroperitoneal type in 4 cases. The surgeries were performed by a combined anterior and posterior approach in 4 cases, a posterior approach in 4 cases, and an anterior approach in 3 cases. The tumors were removed via piecemeal total or subtotal excision in 7 cases, partial excision in 3 cases, and enucleation in 1 case. After surgery, symptoms improved in all cases. The tumor recurred in 2 patients after partial excision. No patients receiving piecemeal total or subtotal excision showed recurrence. One patient developed motor weakness after piecemeal subtotal excision, but the symptoms resolved. CONCLUSIONS: Adopting an appropriate surgical approach based on the location of the tumor is important. Piecemeal total or subtotal excision, with parts of the capsule adjacent to nerves left behind may help achieve a good outcome, avoiding a postoperative neurologic deficit.
自然縮小傾向を示した胸椎部砂時計腫の1例

鈴木学, 相澤俊峰, 橋本功, 菅野晴夫, 小野田祥人, 衛藤俊光, 半田恭一, 大野木孝嘉, 井樋栄二

東日本整形災害外科学会雑誌　31　(3)　371-371　2019年8月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
Destructive discovertebral degenerative diseaseの1例

松田倫治, 相澤俊峰, 橋本功, 菅野晴夫, 山屋誠司, 衛藤俊光, 半田恭一, 井樋栄二

東北整形災害外科学会雑誌　62　(1)　154-154　2019年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
東北大学脊椎外科懇話会手術登録

相澤俊峰, 国分正一, 佐藤哲朗, 田中靖久, 笠間史夫, 村上栄一, 小澤浩司, 兵藤弘訓, 古泉豊, 両角直樹, 星川健, 川原央, 小川真司, 日下部隆, 中川智刀, 橋本功, 菅野晴夫, 東北大学脊椎外科懇話会

東北整形災害外科学会雑誌　62　(1)　201-201　2019年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
Adjacent segment degeneration after fusion spinal surgery-a systematic review. 国際誌査読有り

Ko Hashimoto, Toshimi Aizawa, Haruo Kanno, Eiji Itoi

International orthopaedics　43　(4)　987-993　2019年4月

DOI： 10.1007/s00264-018-4241-z 　

ISSN：0341-2695

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PURPOSE: Adjacent segment degeneration (ASDeg) and disease (ASDis) have become major concerns after fusion surgery. However, there is no definitive data or knowledge about the incidence or risk factors. The review discusses the incidence and risk factors and prevention of ASDeg and ASDis in the relevant literature. METHODS: We performed a systematic review of meta-analyses, randomized control trials, and cohort studies published in English to provide evidence-based information about ASDeg and ASDis. RESULTS: According to a meta-analysis, the pooled incidence of ASDeg after lumbar and cervical fusion surgery was 26.6% and 32.8%, respectively. Approximately 1/4-1/3 of ASDeg progressed to ASDis. Risk factors after cervical fusion surgery were young age, pre-existing disc degeneration, short fusion segment, high T1 slope, disruption of adjacent soft tissue, and plate placement close to the adjacent disc. The risk factors of ASDeg and ASDis after lumbar fusion surgery were age, genetic factors, high body mass index, pre-existing adjacent segment degeneration, laminectomy at the adjacent level of fusion, excessive distraction of the fusion level, insufficient lumbar lordosis, multilevel fixation, floating fusion, coronal wedging of L5-S disc, pelvic tilt, and osteoporosis. Motion-preserving surgeries seem to have less risk of ASDeg and ASDis than conventional fusion surgery both in the lumbar and cervical spine. CONCLUSIONS: The existent literature points out variables involved in ASDeg and ASDis. High evidence-level studies should provide more relevant data to guide strategies for avoiding ASDeg and ASDis.
Minimally invasive discectomy for lumbar disc herniation: current concepts, surgical techniques, and outcomes. 国際誌査読有り

Haruo Kanno, Toshimi Aizawa, Ko Hahimoto, Eiji Itoi

International orthopaedics　43　(4)　917-922　2019年4月

DOI： 10.1007/s00264-018-4256-5 　

ISSN：0341-2695

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PURPOSE: To date, various minimally invasive surgeries for lumbar disc herniation (LDH) have been performed in many countries, including microendoscopic discectomy (MED) and percutaneous endoscopic discectomy (PED). We herein report the surgical indications, current concepts, and techniques of minimally invasive discectomy for LDH, including MED and PED. The postoperative outcomes and risks of complications compared with conventional discectomy are also discussed. METHODS: By reviewing past literatures, the current concepts, surgical techniques, and clinical outcomes were described. RESULTS: Minimally invasive discectomy is generally performed using a transmuscular approach with an endoscopic technique and can reduce muscle and soft tissue damage. The minimal invasiveness can also reduce the severity of postoperative pain and improve patient satisfaction compared with conventional open discectomy. Based on the data of previous systematic reviews and meta-analyses, minimally invasive lumbar discectomy, such as MED and PED, appears to be safe and effective alternatives to open discectomy for patients with symptomatic LDH. These minimally invasive surgeries can provide beneficial effects to shorten the hospital stay and time to return to work. However, minimally invasive discectomy has a demanding learning curve. Only a well-trained surgeon and support team should perform these less invasive procedures. CONCLUSIONS: Clinical evidence supporting the superiority of MED and PED is still limited. Well-designed prospective multicentered randomized controlled trials with large samples are therefore needed in order to draw a convincing conclusion.
脊椎・脊髄外科手術に関係した遠隔脳出血の発生頻度 11年間の前向き研究

相澤俊峰, 小澤浩司, 菅野晴夫, 橋本功, 小野田祥人, 松田倫治, 井樋栄二

日本整形外科学会雑誌　93　(3)　S873-S873　2019年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
Pitfalls during Sacroiliac Joint Arthrodesis for Patients with Severe Sacroiliac Joint Pain: Report of Three Cases with Sacral Dysmorphism Induced by Lumbosacral Transitional Vertebrae. 国際誌

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa, Takashi Watanabe, Hiroshi Ozawa

Journal of orthopaedic case reports　10　(1)　54-57　2019年

DOI： 10.13107/jocr.2019.v10.i01.1634 　

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Introduction: Lumbosacral transitional vertebrae (LSTV) can cause sacral dysmorphism. Sacroiliac joint (SIJ) arthrodesis has been widely performed as the last resort for severe SIJ pain. We report three kinds of technical pitfalls identified in the surgical records of SIJ arthrodesis for the patients with sacral dysmorphism induced by LSTV. Case Report: For the cases of a 34-year-old man with LSTV Castellvi's Type IV, anterior SIJ arthrodesis using a plate and screws was performed. The most cranial sacral foramen was larger and irregularly round, and the nerve root ran to the lateral side from the deformed foramen more than usual. A firm medial traction of the nerve root together with the psoas major muscle for the purpose of attaching a plate and inserting screws on the sacrum side could cause the temporary radiculopathy. For a 26-year-old woman with a thin sacral alar due to IIIb, SIJ arthrodesis using multi screws with the posterolateral approach was performed. The most cranial screw penetrated the anterior margin of the sacrum and caused nerve root injury. For a 35-year-old man with Ib, posterior SIJ arthrodesis was attempted using screws and cylinder cages. The insertion of the implants using the posterior approach was technically challenging due to the small size of the sacrum. Conclusions: Pre-surgical planning for SIJ arthrodesis, including a surgical approach, is particularly important when we see patients with sacral dysmorphism induced by each type of LSTV. The presented surgical pitfalls will be valuable when surgeons perform SIJ arthrodesis for patients with LSTV.
Reoperation Rates after Laminoplasty for Cervical Disorders: A 26-Year Period Survival Function Method Analysis.

Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa, Yasuhisa Tanaka, Takashi Kusakabe, Naoki Morozumi, Yutaka Koizumi, Tetsuro Sato, Hironori Hyodo, Tomowaki Nakagawa, Eiji Takahashi, Takeshi Hoshikawa, Hideki Imaizumi, Shinji Ogawa, Fumio Kasama, Haruo Kanno, Eiji Itoi, Shoichi Kokubun

Spine surgery and related research　3　(4)　304-311　2019年

DOI： 10.22603/ssrr.2019-0028 　

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Introduction: Laminoplasty is a common surgery for cervical myelopathy. Previous studies have analyzed the reoperation rates in posterior decompression surgeries of the cervical spine. However, few studies have solely focused on midline-splitting laminoplasty (MSL) using a large number of patients. This aims to analyze the reoperation rates after MSL using the survival function method. Methods: Between 1988 and 2013, 4,208 MSLs were performed as a primary operation for cervical myelopathy and enrolled in our spinal surgery registration system. The Kaplan-Meier survival function method was used to analyze the rates of reoperation. Results: Of 4,208 patients with primary MSL, 40 underwent reoperation for neurological complications. The overall reoperation rate was 0.26%, 0.64%, 0.83%, 0.93%, and 0.95% at 1, 5, 10, 20, and >20 years, respectively. The causes of reoperation were postoperative cervical radiculopathy in 10 patients, stenosis at an adjacent level in 8, stenosis due to failed "open-door" lamina in 6, instability of the cervical spine in 4, cervical disc herniation in 3, elongation of ossification of the posterior longitudinal ligament in 3, spinal cord injury in 1, fracture of the cervical spine in 1, postoperative scar formation in 1, ossification of anterior longitudinal ligament in 1, and unknown in 2. The number of patients with surgical site infection (SSI) who needed surgical debridement was 34 (0.81%). Conclusions: Excluding reoperations for SSI, the reoperation rate of MSL was approximately 1.0% at the maximum of 26 years after surgery. MSL was determined to be a reliable surgical procedure regarding postoperative complications requiring additional surgeries.
Enhancing percutaneous pedicle screw fixation with hydroxyapatite granules: A biomechanical study using an osteoporotic bone model. 国際誌査読有り

Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi

PloS one　14　(9)　e0223106　2019年

DOI： 10.1371/journal.pone.0223106 　

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INTRODUCTION: Percutaneous pedicle screw (PPS) can provide internal fixation of the thoracolumbar spine through a minimally invasive surgical procedure. PPS fixation has been widely used to treat various spinal diseases. Rigid fixation of PPS is essential for managing osteoporotic spine in order to prevent the risks of screw loosening and implant failure. We recently developed a novel augmentation method using hydroxyapatite (HA) granules for PPS fixation. The aim of this study was to evaluate the strength and stiffness of PPS fixation augmented with HA granules using an osteoporotic bone model. METHODS: Screws were inserted into uniform synthetic bone (sawbones) with and without augmentation. The uniaxial pullout strength and insertion torque of the screws were evaluated. In addition, each screw underwent cyclic toggling under incrementally increasing physiological loads until 2 mm of screwhead displacement occurred. The maximal pullout strength (N), maximal insertion torque (N·cm), number of toggle cycles and maximal load (N) required to achieve 2-mm screwhead displacement were compared between the screws with and without augmentation. RESULTS: The maximal pullout strength was significantly stronger for screws with augmentation than for those without augmentation (302 ± 19 N vs. 254 ± 17 N, p < 0.05). In addition, the maximal insertion torque was significantly increased in screws with augmentation compared to those without augmentation (48 ± 4 N·cm vs. 26 ± 5 N·cm, p < 0.05). Furthermore, the number of toggle cycles and the maximal load required to reach 2 mm of displacement were significantly greater in screws with augmentation than in those without augmentation (106 ± 9 vs. 52 ± 10 cycles; 152 ± 4 N vs. 124 ± 5 N, p < 0.05). CONCLUSIONS: Augmentation using HA granules significantly enhanced the rigidity of PPS fixation in the osteoporotic bone model. The present study suggested that novel augmentation with HA granules may be a useful technique for PPS fixation in patients with osteoporotic spine.
Perioperative Complications After Surgery for Thoracic Ossification of Posterior Longitudinal Ligament: A Nationwide Multicenter Prospective Study. 国際誌

Shiro Imagama, Kei Ando, Kazuhiro Takeuchi, Satoshi Kato, Hideki Murakami, Toshimi Aizawa, Hiroshi Ozawa, Tomohiko Hasegawa, Yukihiro Matsuyama, Masao Koda, Masashi Yamazaki, Hirotaka Chikuda, Shigeo Shindo, Yukihiro Nakagawa, Atsushi Kimura, Katsushi Takeshita, Kanichiro Wada, Hiroyuki Katoh, Masahiko Watanabe, Kei Yamada, Takeo Furuya, Takashi Tsuji, Shunsuke Fujibayashi, Kanji Mori, Yoshiharu Kawaguchi, Kota Watanabe, Morio Matsumoto, Toshitaka Yoshii, Atsushi Okawa

Spine　43　(23)　E1389-E1397　2018年12月1日

DOI： 10.1097/BRS.0000000000002703 　

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STUDY DESIGN: Prospective, multicenter, nationwide study. OBJECTIVE: To investigate perioperative complications and risk factors in surgery for thoracic ossification of the posterior longitudinal ligament (T-OPLL) using data from the registry of the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. SUMMARY OF BACKGROUND DATA: There is no prospective multicenter study of surgical complications and risk factors for T-OPLL, and previous multicenter retrospective studies have lacked details. METHODS: Surgical methods, preoperative radiographic findings, pre- and postoperative thoracic myelopathy (Japanese Orthopaedic Association [JOA] score), prone and supine position test (PST), intraoperative ultrasonography, and intraoperative neurophysiological monitoring (IONM) were investigated prospectively in 115 cases (males: 55, females: 60, average age 53.1 y). Factors related to perioperative complications and risk factors for postoperative motor palsy were identified. RESULTS: Posterior decompression and fusion with instrumentation with or without dekyphosis was performed in 85 cases (74%). The JOA recovery rate at 1 year after surgery in all cases was 55%. Motor palsy occurred postoperatively in 37 cases (32.2%), with a mean recovery period of 2.7 months. A long recovery period for postoperative motor palsy was significantly associated with a high number of T-OPLL levels (P < 0.0001), lower preoperative JOA score (P < 0.05), and greater estimated blood loss (P < 0.05). Perioperative complications or postoperative motor palsy were significantly related to a higher number of T-OPLL levels, comorbid ossification of ligamentum flavum rate, lower preoperative JOA score, higher preoperative positive PST rate, more surgical invasiveness, a lower rate of intraoperative spinal cord floating in ultrasonography, and higher rate of deterioration of IONM. CONCLUSION: This study firstly demonstrated the perioperative complications with high postoperative motor palsy rate in a nationwide multicenter prospective study. Surgical outcomes for T-OPLL should be improved by identifying and preventing perioperative complications with significant risk factors. LEVEL OF EVIDENCE: 3.
Sacroiliac joint arthrodesis for chronic sacroiliac joint pain: an anterior approach and clinical outcomes with a minimum 5-year follow-up. 国際誌査読有り

Eiichi Murakami, Daisuke Kurosawa, Toshimi Aizawa

Journal of neurosurgery. Spine　29　(3)　279-285　2018年9月

DOI： 10.3171/2018.1.SPINE17115 　

ISSN：1547-5654

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OBJECTIVE The authors evaluated the outcomes of sacroiliac joint (SIJ) arthrodesis via an original anterior approach to the upper anterior surface of the SIJ in patients with a minimum of 5 years' follow-up. METHODS The authors performed anterior SIJ arthrodesis in 45 patients between 2001 and 2015. Of these patients, 27 (11 men and 16 women; mean age at surgery 49 [24-86] years) were followed up for a minimum of 5 years (average 113 months, range 61-157 months). In the 14 patients in the earlier period of this study, the authors used an anterior approach to expose the SIJ by separating the iliac muscle from the iliac bone and performed internal fixation. In the 13 patients later in the study, the authors changed to a pararectal approach, which involved an incision along the lateral border of the rectus abdominal muscle. Then, extraperitoneally, the upper anterior surface of the SIJ was exposed between the psoas major muscle and the iliac muscle. RESULTS Among the 27 patients, 21 had unilateral anterior arthrodesis alone, 4 required additional posterior arthrodesis, and 2 required pelvic ring arthrodesis because of later pain on the opposite side. In the 21 patients with a unilateral anterior arthrodesis, outcome according to the modified Macnab criteria was excellent in 7, good in 11, and fair in 3. Outcomes were excellent, good, fair, and poor in 1 patient each among the 4 with additional posterior fusion. Outcomes were good and poor for 1 patient each among those with pelvic ring arthrodesis. All 27 patients demonstrated bone union of the SIJ on CT. Lateral femoral cutaneous neuralgia developed in 7 of the 27 patients; 6 patients had undergone the initial anterior method and 1 the later method. CONCLUSIONS Anterior SIJ arthrodesis was effective in most patients with severe SIJ pain resistant to conservative therapy. This approach has the advantage of direct curettage and bone graft into the wide area of the SIJ, which result in good bone union. In particular, the authors' current pararectal approach could decrease the potential risk of lateral cutaneous injury.
The effect of morphine added to periarticular multimodal drug injection or spinal anesthesia on pain management and functional recovery after total knee arthroplasty. 査読有り

Seiya Miyamoto, Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Akira Sasaki, Ikuo Maeda, Masayuki Kamimura, Atsushi Takahashi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　23　(5)　801-806　2018年9月

DOI： 10.1016/j.jos.2018.04.013 　

ISSN：0949-2658

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BACKGROUND: The efficacy of morphine added to periarticular multimodal drug injection (PMDI) for pain management after total knee arthroplasty (TKA) is controversial. Adding morphine to spinal anesthesia has reportedly improved pain relief for the first 24 h. We examined the effect of morphine added to PMDI or spinal anesthesia on pain management and functional recovery after TKA. METHODS: A total of 97 patients were randomized into three groups: in Group A (34 patients), 10 mg morphine was added to PMDI; Group B (31 patients), 0.1 mg morphine was added to spinal anesthesia; and Group C (32 patients), morphine was added to neither the PMDI nor spinal anesthetic. To evaluate the efficacy of added morphine for pain management, we assessed rest pain, the number of times analgesics were used, and the time period until the first analgesic use. The adverse effects of morphine were assessed by counting the numbers of times vomiting occurred and antiemetics were used. Functional recovery was evaluated by recording the range of motion of the knee and the date of ability to walk. RESULTS: Rest pain was the least in Group B at 6 and 12 h after operation. The number of times analgesics were used was the least in Group B. The time period until the first analgesic use was the longest in Group B. The number of vomiting episodes was the least in Group C. The number of times antiemetics were used was higher in Group A than in Group C. There were no significant differences in the range of motion and date of ability to walk among the three groups. CONCLUSIONS: The efficacy of morphine added to PMDI was limited, and that of morphine added to spinal anesthesia disappeared within 20 h postoperatively. Adding morphine to PMDI or spinal anesthesia did not improve functional recovery and caused some adverse effects.
Spinal Cord Swelling After Surgery in Cervical Spondylotic Myelopathy: Relationship With Intramedullary Gd-DTPA Enhancement on MRI. 国際誌査読有り

Hiroshi Ozawa, Toshimi Aizawa, Satoshi Tateda, Ko Hashimoto, Haruo Kanno, Masato Ishizuka

Clinical spine surgery　31　(7)　E363-E367-E367　2018年8月

DOI： 10.1097/BSD.0000000000000664 　

ISSN：2380-0186

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STUDY DESIGN: This is a prospective multicenter study. SUMMARY OF BACKGROUND DATA: Postoperative spinal cord swelling has been reported in patients with cervical spondylotic myelopathy. In the cases of the spinal cord swelling, the involvement in the intramedullary gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) enhancement on magnetic resonance imaging (MRI) was referred. OBJECTIVE: The prevalence and clinical relevance of postoperative spinal cord swelling and its relationship with intramedullary Gd-DTPA enhancement in patients with cervical spondylotic myelopathy were investigated. SUBJECTS AND METHODS: A total of 683 consecutive patients with cervical spondylotic myelopathy who underwent laminoplasty were examined. T1, T2, and Gd-DTPA-enhanced MRI were performed before surgery. Patients with intramedullary Gd-DTPA enhancement were allocated to the enhancement group. Fifty consecutive cases who did not exhibit intramedullary Gd-DTPA enhancement were allocated to the nonenhancement group. Both groups underwent MRI examinations at 1 month and 1 year after surgery. RESULTS: The prevalence of spinal cord swelling in the enhancement group (26%) was significantly higher than that in the nonenhancement group (4%) (P=0.0038). At 1 year after surgery, spinal cord swelling had resolved in all patients in the nonenhancement group, while it persisted in 3 of 13 patients (23%) in the enhancement group. On multiple regression analysis, intramedullary Gd-DTPA enhancement rather than the spinal cord swelling showed a significant influence in terms of recovery of the Japanese Orthopedic Association score. CONCLUSIONS: Surgical outcomes of patients with postoperative swelling should be evaluated separately according to the presence or absence of intramedullary Gd-DTPA enhancement on MRI. Spinal cord swelling associated with intramedullary Gd-DTPA enhancement was indicative of poor prognosis.
Recurrence of ossification of ligamentum flavum at the same intervertebral level in the thoracic spine: a report of two cases and review of the literature. 国際誌査読有り

Haruo Kanno, Tadahisa Takahashi, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　27　(Suppl 3)　359-367　2018年7月

DOI： 10.1007/s00586-017-5281-6 　

ISSN：0940-6719

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PURPOSE: Ossification of the ligamentum flavum (OLF) is a possible cause of thoracic myelopathy. We report two rare cases with recurrent thoracic myelopathy caused by OLF markedly re-extended at the same intervertebral level after the primary surgery. METHODS: Both patients had thoracic myelopathy caused by OLF and underwent decompressive laminectomy and resection of the OLF in the primary surgery. However, the neurological conditions gradually deteriorated following recovery after the primary surgery due to the recurrent OLF at the same intervertebral level. RESULTS: These patients were successfully treated by revision surgery via resection of the recurrent OLF and posterior spinal fusion with instrumentation. Two years after the second surgery, the neurological disturbance was resolved satisfactorily, and re-growth of the resected ossified lesion was not observed. CONCLUSIONS: The recurrence of OLF following resection of the ossified lesions is exceedingly rare but should be noted in patients treated surgically for thoracic myelopathy due to OLF.
Recurrent primary osseous hemangiopericytoma in the thoracic spine: a case report and literature review. 国際誌査読有り

Takahiro Onoki, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　27　(Suppl 3)　386-392　2018年7月

DOI： 10.1007/s00586-017-5322-1 　

ISSN：0940-6719

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PURPOSE: Primary osseous hemangiopericytoma (HPC) of the spine is exceedingly rare. HPC has malignant potential and has the capacity for metastasis and local recurrence. We herein present the first case of recurrent primary osseous HPC in the thoracic spine that was successfully treated by total spondylectomy at three vertebral levels and spinal reconstruction. METHODS: We performed a two-stage operation for recurrent HPC using anterior and posterior approaches at the T5-T7 vertebrae. The preoperative embolization of the tumor was performed to prevent massive intraoperative bleeding. Then, total spondylectomy was performed (T5-T7) to resect the tumor. Anterior spinal reconstruction and posterior instrumentation were performed, with abundant bone autograft and allograft used to achieve sufficient boney fusion following the removal of the tumor. RESULTS: At 2 years after surgery, the patient had made a sufficient recovery from his symptoms. The bone union was complete without tumor recurrence or implant failure. CONCLUSIONS: Total spondylectomy and spinal reconstruction with instrumentation might be useful for performing the safe and adequate excision of recurrent HPC of the spine. However, patients should be closely monitored to detect local recurrence and the malignant degeneration of the tumor after surgery.
再発した硬膜内髄外血管腫の2例

半田恭一, 相澤俊峰, 橋本功, 菅野晴夫, 山屋誠司, 松田倫治, 衛藤俊光, 小澤浩司

東北整形災害外科学会雑誌　61　(1)　234-234　2018年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
Study protocol for the G-SPIRIT trial: a randomised, placebo-controlled, double-blinded phase III trial of granulocyte colony-stimulating factor-mediated neuroprotection for acute spinal cord injury. 国際誌

Masao Koda, Hideki Hanaoka, Takatoshi Sato, Yasuhisa Fujii, Michiko Hanawa, Sho Takahashi, Takeo Furuya, Yasushi Ijima, Junya Saito, Mitsuhiro Kitamura, Seiji Ohtori, Yukei Matsumoto, Tetsuya Abe, Kei Watanabe, Toru Hirano, Masayuki Ohashi, Hirokazu Shoji, Tatsuki Mizouchi, Ikuko Takahashi, Norio Kawahara, Masahito Kawaguchi, Yugo Orita, Takeshi Sasamoto, Masahito Yoshioka, Masafumi Fujii, Katsutaka Yonezawa, Daisuke Soma, Hiroshi Taneichi, Daisaku Takeuchi, Satoshi Inami, Hiroshi Moridaira, Haruki Ueda, Futoshi Asano, Yosuke Shibao, Ikuo Aita, Yosuke Takeuchi, Masaya Mimura, Jun Shimbo, Yukio Someya, Sumio Ikenoue, Hiroaki Sameda, Kan Takase, Yoshikazu Ikeda, Fumitake Nakajima, Mitsuhiro Hashimoto, Tomoyuki Ozawa, Fumio Hasue, Takayuki Fujiyoshi, Koshiro Kamiya, Masahiko Watanabe, Hiroyuki Katoh, Yukihiro Matsuyama, Yu Yamamoto, Daisuke Togawa, Tomohiko Hasegawa, Sho Kobayashi, Go Yoshida, Shin Oe, Tomohiro Banno, Hideyuki Arima, Koji Akeda, Eiji Kawamoto, Hiroshi Imai, Toshihiko Sakakibara, Akihiro Sudo, Yasuo Ito, Tsuyoshi Kikuchi, Shuhei Osaki, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Shinji Kotaka, Hideo Baba, Tsuyoshi Okudaira, Hiroaki Konishi, Takayuki Yamaguchi, Keigo Ito, Yoshito Katayama, Taro Matsumoto, Tomohiro Matsumoto, Masaru Idota, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Toshimitsu Eto, Takehiro Sugaya, Michiharu Matsuda, Kazunari Fushimi, Satoshi Nozawa, Chizuo Iwai, Toshihiko Taguchi, Tsukasa Kanchiku, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Masashi Yamazaki

BMJ open　8　(5)　e019083　2018年5月5日

DOI： 10.1136/bmjopen-2017-019083 　

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INTRODUCTION: Granulocyte colony-stimulating factor (G-CSF) is generally used for neutropaenia. Previous experimental studies revealed that G-CSF promoted neurological recovery after spinal cord injury (SCI). Next, we moved to early phase of clinical trials. In a phase I/IIa trial, no adverse events were observed. Next, we conducted a non-randomised, non-blinded, comparative trial, which suggested the efficacy of G-CSF for promoting neurological recovery. Based on those results, we are now performing a phase III trial. METHODS AND ANALYSIS: The objective of this study is to evaluate the efficacy of G-CSF for acute SCI. The study design is a prospective, multicentre, randomised, double-blinded, placebo-controlled comparative study. The current trial includes cervical SCI (severity of American Spinal Injury Association (ASIA) Impairment Scale B/C) within 48 hours after injury. Patients are randomly assigned to G-CSF and placebo groups. The G-CSF group is administered 400 µg/m2/day×5 days of G-CSF in normal saline via intravenous infusion for 5 consecutive days. The placebo group is similarly administered a placebo. Our primary endpoint is changes in ASIA motor scores from baseline to 3 months. Each group includes 44 patients (88 total patients). ETHICS AND DISSEMINATION: The study will be conducted according to the principles of the World Medical Association Declaration of Helsinki and in accordance with the Japanese Medical Research Involving Human Subjects Act and other guidelines, regulations and Acts. Results of the clinical study will be submitted to the head of the respective clinical study site as a report after conclusion of the clinical study by the sponsor-investigator. Even if the results are not favourable despite conducting the clinical study properly, the data will be published as a paper. TRIAL REGISTRATION NUMBER: UMIN000018752.
An increase in the degree of olisthesis during axial loading reduces the dural sac size and worsens clinical symptoms in patients with degenerative spondylolisthesis. 国際誌査読有り

Haruo Kanno, Toshimi Aizawa, Hiroshi Ozawa, Yutaka Koizumi, Naoki Morozumi, Eiji Itoi

The spine journal : official journal of the North American Spine Society　18　(5)　726-733　2018年5月

DOI： 10.1016/j.spinee.2017.08.251 　

ISSN：1529-9430

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BACKGROUND CONTEXT: Previous studies have shown that axial loading during magnetic resonance imaging (MRI) significantly reduces the size of the dural sac compared with conventional MRI in patients with degenerative lumbar disease. In our previous study, axial-loaded MRI showed a significantly larger degree of olisthesis than conventional MRI in patients with degenerative spondylolisthesis (DS). Furthermore, the degree of olisthesis on axial-loaded MRI correlated more strongly with that observed on X-ray in the upright position. However, no study has investigated whether or not the increase in the degree of olisthesis during axial loading correlates with the reduction in the dural sac size and affects the severity of clinical symptoms in patients with DS. PURPOSE: The objective of this study was to determine whether or not the increase in the degree of olisthesis correlates with the reduction of the dural sac cross-sectional area (DCSA) detected on axial-loaded MRI and worsens the severity of clinical symptoms in patients with DS. STUDY DESIGN/SETTING: This is an imaging cohort study. PATIENT SAMPLE: A total of 41 consecutive patients with DS were prospectively evaluated in this study. OUTCOME MEASURES: The outcome measures include the degree of olisthesis, the DCSA, the Pearson correlation coefficient, and the severity of clinical symptoms. MATERIALS AND METHODS: The differences in the degree of olisthesis and the DCSA between conventional and axial-loaded MRIs were determined. The Pearson correlation coefficient of the increase in the degree of olisthesis with the reduction in the DCSA during axial loading was calculated. The reduction in the DCSA and the severity of clinical symptoms in patients exhibiting a ≥2-mm increase in the degree of olisthesis were compared with those in patients exhibiting a <2-mm increase. RESULTS: The increase in the degree of olisthesis was significantly correlated with the reduction in the DCSA during axial loading (Pearson correlation coefficient=0.63, p<.001). The reduction in the DCSA during axial loading in patients with a ≥2-mm increase in the degree of olisthesis (26±3 mm2) was significantly greater than in those with a <2-mm increase (13±2 mm2) (p<.01). Clinical symptoms such as walking distance and activity of daily living evaluated using the Japanese Orthopaedic Association score were significantly worse in patients with a ≥2-mm increase in the degree of olisthesis (117±19 m and 6.7±0.5 points, respectively) than in those with a <2-mm increase (236±36 m and 8.4±0.4 points, respectively) (p<.05). CONCLUSIONS: The present study demonstrated that the increase in the degree of olisthesis was significantly correlated with the reduction in the dural sac size detected on axial-loaded MRI and worsened the severity of clinical symptoms in patients with DS. These results suggest that axial-loaded MRI may be a useful imaging study for detecting dynamic changes in the degree of olisthesis during axial loading to the lumbar spine related to the narrowing of the spinal canal and the severity of clinical symptoms in the assessment of patients with DS.
HA顆粒による経皮的椎弓根スクリューの新たな補強法の検討生体力学的解析による骨粗鬆症脊椎への有効性の解析

菅野晴夫, 相澤俊峰, 橋本功, 山屋誠司, 井樋栄二

日本整形外科学会雑誌　92　(2)　S43-S43　2018年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
仙椎部巨大神経鞘腫の治療成績

半田恭一, 小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 舘田聡, 井樋栄二

日本整形外科学会雑誌　92　(3)　S791-S791　2018年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
腰椎MRIのnerve root sedimentation signとredundant nerve rootの有無による脊柱管狭窄・臨床症状の比較

菅野晴夫, 相澤俊峰, 橋本功, 山屋誠司, 井樋栄二

日本整形外科学会雑誌　92　(3)　S1069-S1069　2018年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
3D fusion imagingを応用した頸椎内視鏡下後方除圧術の3次元手術シミュレーションの有用性と課題

山屋誠司, 野村和教, 中村陽介, 中尾慎一, 中尾裕次, 綿貫匡則, 綿貫昭則, 菅野晴夫, 橋本功, 相澤俊峰, 井樋栄二, 山田宏, 吉田宗人

Journal of Spine Research　9　(3)　236-236　2018年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
HA顆粒を用いた経皮的椎弓根スクリュー固定の補強法骨粗鬆症脊椎への有効性の生体力学的解析

菅野晴夫, 相澤俊峰, 橋本功, 山屋誠司, 井樋栄二

Journal of Spine Research　9　(3)　383-383　2018年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
片側椎弓切除による脊髄腫瘍摘出術の検証脊髄腫瘍約900手術症例の解析

橋本功, 相澤俊峰, 菅野晴夫, 山屋誠司, 小澤浩司, 国分正一

Journal of Spine Research　9　(3)　554-554　2018年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
腰椎MRIにおけるnerve root sedimentation signとredundant nerve rootの検討脊柱管狭窄・臨床症状との関連

菅野晴夫, 相澤俊峰, 橋本功, 山屋誠司, 井樋栄二

Journal of Spine Research　9　(3)　577-577　2018年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
超高齢化に伴う脊椎外科手術数の変化

相澤俊峰, 田中靖久, 日下部隆, 橋本功, 菅野晴夫, 両角直樹, 古泉豊, 小川真司, 星川健, 兵藤弘訓, 村上栄一, 笠間忠夫, 佐藤哲朗, 小澤浩司, 国分正一

Journal of Spine Research　9　(2)　125-130　2018年2月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
Treatment strategy for sacroiliac joint-related pain at or around the posterior superior iliac spine. 国際誌査読有り

Eiichi Murakami, Daisuke Kurosawa, Toshimi Aizawa

Clinical neurology and neurosurgery　165　43-46　2018年2月
出版者・発行元： Elsevier B.V.
DOI： 10.1016/j.clineuro.2017.12.017 　

ISSN：1872-6968 0303-8467
Diagnosis of benign notochordal cell tumor of the spine: is a biopsy necessary? 国際誌

Satoshi Tateda, Ko Hashimoto, Toshimi Aizawa, Haruo Kanno, Shin Hitachi, Eiji Itoi, Hiroshi Ozawa

Clinical case reports　6　(1)　63-67　2018年1月

DOI： 10.1002/ccr3.1287 　

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Benign notochordal cell tumor is a benign intraosseous lesion, demonstrates characteristic imaging features. The lesion demonstrates low-signal intensity in T1-weighted images, high-signal intensity in T2-weighted images, and no enhancement with contrast medium in MRI and slight osteosclerosis in CT. If typical imaging findings are identified, biopsy is not necessary.
Femoral footprint of the popliteus tendon may be at the risk of damage during total knee arthroplasty. 国際誌査読有り

Takashi Aki, Takehiko Sugita, Atsushi Takahashi, Toshimi Aizawa, Masayuki Kamimura, Akira Sasaki, Naohisa Miyatake, Eiji Itoi

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA　25　(12)　3718-3722　2017年12月

DOI： 10.1007/s00167-016-4177-z 　

ISSN：0942-2056

eISSN：1433-7347
Groin pain associated with sacroiliac joint dysfunction and lumbar disorders. 国際誌査読有り

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa

Clinical neurology and neurosurgery　161　104-109　2017年10月
出版者・発行元： Elsevier B.V.
DOI： 10.1016/j.clineuro.2017.08.018 　

ISSN：1872-6968 0303-8467
HA顆粒を用いた経皮的椎弓根スクリュー固定に対する新たなaugmentation法生体力学的解析による骨粗鬆症脊椎への有効性の解析

菅野晴夫, 相澤俊峰, 橋本功, 井樋栄二

日本整形外科学会雑誌　91　(8)　S1638-S1638　2017年8月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
Body Mass Index 35kg/m2以上の患者の脊椎手術における問題点

八幡健一郎, 相澤俊峰, 橋本功, 菅野晴夫, 舘田聡, 井樋栄二, 小澤浩司

東北整形災害外科学会雑誌　60　(1)　191-191　2017年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
同一椎間に再発した胸椎黄色靱帯骨化症の2例

高橋忠久, 菅野晴夫, 相澤俊峰, 橋本功, 井樋栄二, 小澤浩司

東北整形災害外科学会雑誌　60　(1)　101-105　2017年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694

詳細を見る詳細を閉じる

症例1(58歳女性)。前医にて黄色靱帯骨化症(OLF)による胸髄症に対し、T9-12椎弓およびOLFの切除が施行されたが、術後11年で両下肢の脱力としびれが再燃したため紹介となった。精査の結果、同一椎間に再発したOLFによる胸髄症と診断され、再発OLF切除およびT8-L2後方固定術を施行した。術後は両下肢のしびれ、筋力が改善し、術後2年でJOAスコアは5/11点まで改善した。症例2(58歳男性)。前医にてOLFによる胸髄症と腰部脊柱管狭窄症に対し、T9-11椎弓切除とL1-5の椎弓切除・後方固定術を施行されたが、術後4年目に両下肢の脱力としびれが再燃し、歩行障害が出現したため紹介となった。精査の結果、OLFの再発とOPLLの増大による胸髄症と診断され、T10/11のOLF切除と大塚法によるOPLL切除、T9-L1後方固定術を行った。術後は症状が改善し、術後1年でJOAスコアは10/11点まで改善した。
Leg symptoms associated with sacroiliac joint disorder and related pain. 国際誌査読有り

Eiichi Murakami, Toshimi Aizawa, Daisuke Kurosawa, Kyoko Noguchi

Clinical neurology and neurosurgery　157　55-58　2017年6月
出版者・発行元： Elsevier B.V.
DOI： 10.1016/j.clineuro.2017.03.020 　

ISSN：1872-6968 0303-8467
Preliminary results of managing large medial tibial defects in primary total knee arthroplasty: autogenous morcellised bone graft. 国際誌査読有り

Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Akira Sasaki, Masayuki Kamimura, Atsushi Takahashi

International orthopaedics　41　(5)　931-937　2017年5月

DOI： 10.1007/s00264-016-3339-4 　

ISSN：0341-2695

eISSN：1432-5195
Successful Management of Gorham-Stout Disease in the Cervical Spine by Combined Conservative and Surgical Treatments: A Case Report. 査読有り

Satoshi Tateda, Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Susumu Ohtsu, Eiji Itoi, Hiroshi Ozawa

The Tohoku journal of experimental medicine　241　(4)　249-254　2017年4月

DOI： 10.1620/tjem.241.249 　

ISSN：0040-8727

eISSN：1349-3329
脊椎手術後の遠隔脳出血発生頻度の前向き研究

相澤俊峰, 小澤浩司, 橋本功, 菅野晴夫, 井樋栄二

日本整形外科学会雑誌　91　(2)　S40-S40　2017年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
片側椎弓切除による脊髄腫瘍摘出術の検証

橋本功, 相澤俊峰, 菅野晴夫, 小澤浩司, 国分正一

日本整形外科学会雑誌　91　(3)　S662-S662　2017年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
腰部脊柱管狭窄症におけるnerve root sedimentation signと臨床症状の重症度の関連

菅野晴夫, 相澤俊峰, 橋本功, 井樋栄二

日本整形外科学会雑誌　91　(3)　S742-S742　2017年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
腰椎椎間孔内・外狭窄病変に対して3D fusion imagingを用いた内視鏡下手術シミュレーションの有用性

山屋誠司, 菅野晴夫, 中村聡, 高橋伸光, 橋本功, 相澤俊峰, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　91　(3)　S829-S829　2017年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
経皮的椎弓根スクリュー固定に対するHA顆粒を用いた新たなaugmentation法

菅野晴夫, 相澤俊峰, 橋本功, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　91　(3)　S837-S837　2017年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
小児脊髄腫瘍に対する片側椎弓切除による腫瘍摘出後脊柱変形

松田倫治, 相澤俊峰, 橋本功, 菅野晴夫, 衛藤俊光, 井樋栄二

Journal of Spine Research　8　(3)　366-366　2017年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
経皮的内視鏡下椎間板摘出術に対する3D fusion imagingを用いた新しい3次元術前計画 exiting nerve injuryを防ぐためのシミュレーション手術

山屋誠司, 菅野晴夫, 中村聡, 高橋伸光, 橋本功, 相澤俊峰, 井樋栄二

Journal of Spine Research　8　(3)　491-491　2017年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
超高齢社会に伴う脊椎疾患の手術数の変化

相澤俊峰, 国分正一, 橋本功, 菅野晴夫, 小澤浩司, 田中靖久, 日下部隆, 両角直樹, 古泉豊, 井樋栄二

Journal of Spine Research　8　(3)　749-749　2017年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
腰部脊柱管狭窄症におけるnerve root sedimentation sign 脊柱管狭窄の程度・臨床症状の重症度との関連

菅野晴夫, 相澤俊峰, 橋本功, 衛藤俊光, 井樋栄二, 小澤浩司

Journal of Spine Research　8　(3)　759-759　2017年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
高齢者脊椎手術(80歳以上)の疫学東北大学脊椎外科懇話会・27年間の脊椎手術登録から

橋本功, 相澤俊峰, 菅野晴夫, 佐藤哲朗, 田中靖久, 両角直樹, 古泉豊, 日下部隆, 小澤浩司, 兵藤弘訓, 井樋栄二, 国分正一

Journal of Spine Research　8　(3)　775-775　2017年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
術後創傷感染症と手術侵襲による炎症反応はどう違うのかダメージ関連分子パターンに着目した検討査読有り

小圷知明, 山田充啓, 相澤俊峰, 橋本功, 井樋栄二, 久志本成樹

日本整形外科学会雑誌　91　(2)　S77-S77　2017年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
脊椎外科周術期におけるダメージ関連分子パターンの動態術後創傷感染症と手術侵襲による炎症反応はどう違うのか? 査読有り

小圷知明, 山田充啓, 相澤俊峰, 橋本功, 井樋栄二, 久志本成樹

Journal of Spine Research　8　(3)　560-560　2017年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
Evaluation of the size and position of the insertion of the anterior medial meniscus root in varus osteoarthritic knees. 国際誌査読有り

Akira Sasaki, Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Masayuki Kamimura, Hirokazu Fujisawa, Atsushi Takahashi

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA　25　(2)　362-367　2017年2月

DOI： 10.1007/s00167-015-3963-3 　

ISSN：0942-2056

eISSN：1433-7347
Comparison of intraoperative anthropometric measurements of the proximal tibia and tibial component in total knee arthroplasty. 査読有り

Naohisa Miyatake, Takehiko Sugita, Toshimi Aizawa, Akira Sasaki, Ikuo Maeda, Masayuki Kamimura, Hirokazu Fujisawa, Atsushi Takahashi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　21　(5)　635-9　2016年9月

DOI： 10.1016/j.jos.2016.06.003 　

ISSN：0949-2658

eISSN：1436-2023
New Diagnostic Support Tool for Patients with Leg Symptoms Caused by Lumbar Spinal Stenosis and Lumbar Intervertebral Disc Herniation: a Self-administered, Self-reported history questionnaire

Aizawa T, Tanaka Y, Yokoyama T, Shimada Y, Yamazaki K, Takei H, Konno S, Kawahara C, Itoi E, Kokubun S

Journal of Orthopaedic Science　21　(5)　579-85　2016年9月

DOI： 10.1016/j.jos.2016.07.012 　
治療に成功した頸椎Gorham病の一例

舘田聡, 相澤俊峰, 橋本功, 菅野晴夫, 井樋栄二, 小澤浩司

東日本整形災害外科学会雑誌　28　(3)　401-401　2016年8月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
骨粗鬆症脊椎に対する経皮的椎弓根スクリューの固定性の生体力学的研究 HA顆粒を用いた新たなaugmentation法の開発と有効性の検討

菅野晴夫, 相澤俊峰, 橋本功, 衛藤俊光, 井樋栄二

日本整形外科学会雑誌　90　(8)　S1710-S1710　2016年8月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
当院におけるBenign notochordal cell tumorの経験

舘田聡, 相澤俊峰, 小澤浩司, 橋本功, 菅野晴夫, 八幡健一郎, 常陸真

東北整形災害外科学会雑誌　59　(1)　235-235　2016年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
良性脊索細胞腫(benign notochordal cell tumor)の臨床的画像的特徴

舘田聡, 小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 八幡健一郎, 井樋栄二, 常陸真

日本整形外科学会雑誌　90　(6)　S1397-S1397　2016年6月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
Comparative study of treatment for distal radius fractures with two different palmar locking plates. 査読有り

Tanaka H, Hatta T, Sasajima K, Itoi E, Aizawa T

The Journal of hand surgery, European volume　41　(5)　536-542　2016年6月

DOI： 10.1177/1753193415625830 　

ISSN：1753-1934
腰部脊柱管狭窄症の保存療法 2年以上手術しなかった症例の検討査読有り

相澤俊峰, 小澤, 浩司, 日下部, 隆, 橋本功, 菅野, 晴夫, 両角, 直樹, 古泉, 豊, 佐藤, 哲朗, 兵藤, 弘訓, 小川, 真司, 笠間, 史夫, 星川, 健, 国分, 正一, 舘田, 聡八幡, 健一郎, 谷, 正太郎, 井樋栄二

東北整形災害外科学会雑誌　59　(1)　20-23　2016年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694

詳細を見る詳細を閉じる

東北大学および関連病院で腰部脊柱管狭窄症(LSS)と診断され、2年以上手術せずに保存療法を施行された32例(男性19例、女性13例、初診時平均71歳(49〜89歳))を対象に、保存療法の実際を調査した。平均観察期間は4.5年(2〜13年)で、これらの症例の責任高位、症状分類、MRIでの狭窄程度、併存症、初診時間欠跛行、治療法、最終経過観察時間欠跛行、治療成績、手術に至らなかった理由を後方視的に検討した。責任高位はL4/5が27例と最多を占め、L3/4が3例、L2/3が2例、L5/Sが1例であった。症状は馬尾型と神経根型が14例、15例と約半数を占め、混合型が3例であった。MRI狭窄率は重度4例、中等度20例、軽度8例であった。併存症は24例75%で、高血圧6例、糖尿病と気管支喘息や睡眠時無呼吸症候群などの呼吸器疾患各5例、狭心症や心不全などの循環器疾患や腎不全など、腎疾患が各4例、癌3例などであった。全例に薬物療法が行われていた。使用された薬剤は非ステロイド性消炎鎮痛剤17例、プロスタグランジンE1が16例、ビタミンB12が13例、プレガバリン12例であった。間欠跛行距離は初診時100m以下12例、100〜500m 9例、500m以上11例が、最終経過観察時は100m以下7例、100〜500m 21例と多くが改善していた。治療成績は改善あるいはやや改善が75%と多くの症状が改善していた。手術に至らなかった理由として症状の他、全身合併症や社会的な問題、医師側の判断などがあった。
Increased facet fluid predicts dynamic changes in the dural sac size on Axial-loaded MRi in patients with lumbar spinal canal stenosis 査読有り

H. Kanno, H. Ozawa, Y. Koizumi, N. Morozumi, T. Aizawa, E. Itoi

American Journal of Neuroradiology　37　(4)　730-735　2016年4月1日
出版者・発行元： American Society of Neuroradiology
DOI： 10.3174/ajnr.A4582 　

ISSN：1936-959X 0195-6108
脊椎外科周術期におけるプレセプシンの動態―術後創傷感染症早期診断における有用性―

小圷知明, 佐藤哲哉, 桑原功行, 工藤大介, 相澤俊峰, 橋本功, 井樋栄二, 久志本成樹

Journal of Spine Research　7　(3)　409　2016年3月25日

ISSN：1884-7137
腰部脊柱管狭窄症におけるnerve root sedimentation signと臨床症状の関係

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

日本整形外科学会雑誌　90　(2)　S201-S201　2016年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
腰部脊柱管狭窄症におけるnerve root sedimentation signと臨床症状の関係

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

Journal of Spine Research　7　(3)　550-550　2016年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
脊椎手術後の遠隔小脳出血後ろ向き研究と前向き研究

相澤俊峰, 芦名善博, 橋本功, 菅野晴夫, 井樋栄二, 小澤浩司

Journal of Spine Research　7　(3)　581-581　2016年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
頸椎前方除圧固定術と椎弓形成術の再手術率生存分析を用いた最長26年間の検討

橋本功, 小澤浩司, 相澤俊峰, 菅野晴夫, 舘田聡, 八幡健一郎, 井樋栄二, 国分正一

Journal of Spine Research　7　(3)　730-730　2016年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
Increasing Incidence of Degenerative Spinal Diseases in Japan during 25 Years: The Registration System of Spinal Surgery in Tohoku University Spine Society. 査読有り

Toshimi Aizawa, Shoichi Kokubun, Hiroshi Ozawa, Takashi Kusakabe, Yasuhisa Tanaka, Takeshi Hoshikawa, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yutaka Koizumi, Tetsuro Sato, Hironori Hyodo, Fumio Kasama, Shinji Ogawa, Eiichi Murakami, Chikashi Kawahara, Jun-Ichiro Yahata, Yushin Ishii, Eiji Itoi

The Tohoku journal of experimental medicine　238　(2)　153-63　2016年2月

DOI： 10.1620/tjem.238.153 　

ISSN：0040-8727

eISSN：1349-3329
Potential risk of excising the femoral insertion of the popliteus tendon during primary total knee arthroplasty: a biometric study. 査読有り

Atsushi Takahashi, Takehiko Sugita, Toshimi Aizawa, Daisuke Chiba, Masayuki Kamimura, Takashi Aki, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　20　(6)　1030-5　2015年11月

DOI： 10.1007/s00776-015-0773-x 　

ISSN：0949-2658

eISSN：1436-2023
高齢者の転倒と認知機能障害大腿骨近位部骨折患者の予備的検討

葛西真理, 目黒謙一, 小澤浩司, 相澤俊峰, 熊居慶一, 今泉秀樹, 大泉晶, 峯岸英絵, 山口智, 井樋栄二

Dementia Japan　29　(3)　410-410　2015年9月
出版者・発行元： (一社)日本認知症学会
ISSN：1342-646X
Autologous morselised bone grafting for medial tibial defects in total knee arthroplasty. 国際誌査読有り

Takehiko Sugita, Toshimi Aizawa, Akira Sasaki, Naohisa Miyatake, Hirokazu Fujisawa, Masayuki Kamimura

Journal of orthopaedic surgery (Hong Kong)　23　(2)　185-9　2015年8月

DOI： 10.1177/230949901502300214 　

ISSN：1022-5536

eISSN：2309-4990
Tumor-induced osteomalacia caused by phosphaturic mesenchymal tumor of the cervical spine. 査読有り

Takeshi Nakamura, Toshimi Aizawa, Takeshi Hoshikawa, Hiroshi Ozawa, Nobuaki Ito, Seiji Fukumoto, Eiji Itoi, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　20　(4)　765-71　2015年7月

DOI： 10.1007/s00776-014-0540-4 　

ISSN：0949-2658
緊急手術を要した胸椎から仙骨にわたる広範囲の術後胸腰椎硬膜下膿瘍の1例

八幡健一郎, 小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 舘田聡, 井樋栄二, 高橋良正, 佐藤哲朗

東北整形災害外科学会雑誌　58　(1)　196-196　2015年6月
出版者・発行元：東北整形災害外科学会
ISSN：1348-8694
Changes in lumbar spondylolisthesis on axial-loaded MRI: do they reproduce the positional changes in the degree of olisthesis observed on X-ray images in the standing position? 国際誌査読有り

Haruo Kanno, Hiroshi Ozawa, Yutaka Koizumi, Naoki Morozumi, Toshimi Aizawa, Yushin Ishii, Eiji Itoi

The spine journal : official journal of the North American Spine Society　15　(6)　1255-62　2015年6月1日

DOI： 10.1016/j.spinee.2015.02.016 　

ISSN：1529-9430

eISSN：1878-1632
頸髄症におけるMRI髄内T2高輝度領域のパターンと病理像の関係について

小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 井樋栄二

日本整形外科学会雑誌　89　(2)　S107-S107　2015年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
荷重MRIによる腰椎変性すべりの動的変化の検討荷重によるすべりの増大と臨床症状の関係

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

Journal of Spine Research　6　(3)　553-553　2015年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
荷重MRIにおける腰部脊柱管狭窄の検討荷重による動的狭窄のリスク因子の解析

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

日本整形外科学会雑誌　89　(3)　S638-S638　2015年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
Referred pain location depends on the affected section of the sacroiliac joint. 国際誌査読有り

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　24　(3)　521-7　2015年3月
出版者・発行元： Springer Verlag
DOI： 10.1007/s00586-014-3604-4 　

ISSN：1432-0932 0940-6719
胸椎砂時計腫の手術成績脊椎固定は必要か? 査読有り

相澤俊峰, 小澤, 浩司, 橋本, 功, 菅野, 晴夫, 舘田, 聡, 矢部, 裕, 八幡, 健一郎, 井樋栄二

Journal of Spine Research　6　(3)　528-528　2015年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
腰椎2大疾患の再手術率脊柱管狭窄症と椎間板ヘルニア再手術率の生存分析査読有り

相澤俊峰, 小澤, 浩司, 橋本, 功, 菅野, 晴夫, 日下部, 隆, 関口, 玲, 佐藤, 哲朗, 高橋, 永次, 両角, 直樹, 国分, 正一, 井樋栄二

日本整形外科学会雑誌　89　(2)　S61-S61　2015年3月
Reoperation rates after fenestration for lumbar spinal canal stenosis: a 20-year period survival function method analysis. 国際誌査読有り

Toshimi Aizawa, Hiroshi Ozawa, Takashi Kusakabe, Yasuhisa Tanaka, Akira Sekiguchi, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yushin Ishii, Tetsuro Sato, Eiji Takahashi, Shoichi Kokubun, Eiji Itoi

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　24　(2)　381-7　2015年2月
出版者・発行元： Maik Nauka-Interperiodica Publishing
DOI： 10.1007/s00586-014-3479-4 　

ISSN：1555-6174 0031-0301
Reoperation rates after fenestration for lumbar spinal canal stenosis: a 20-year period survival function method analysis 査読有り

Toshimi Aizawa, Hiroshi Ozawa, Takashi Kusakabe, Yasuhisa Tanaka, Akira Sekiguchi, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yushin Ishii, Tetsuro Sato, Eiji Takahashi, Shoichi Kokubun, Eiji Itoi

EUROPEAN SPINE JOURNAL　24　(2)　381-387　2015年2月

DOI： 10.1007/s00586-014-3479-4 　

ISSN：0940-6719

eISSN：1432-0932
Quality of life after bilateral total knee arthroplasty determined by a 3-year longitudinal evaluation using the Japanese knee osteoarthritis measure. 査読有り

Takehiko Sugita, Yasuhiro Kikuchi, Toshimi Aizawa, Akira Sasaki, Naohisa Miyatake, Ikuo Maeda

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　20　(1)　137-42　2015年1月

DOI： 10.1007/s00776-014-0645-9 　

ISSN：0949-2658

eISSN：1436-2023
Medial meniscus tear morphology and related clinical symptoms in patients with medial knee osteoarthritis. 国際誌査読有り

Masayuki Kamimura, Jutaro Umehara, Atsushi Takahashi, Toshimi Aizawa, Eiji Itoi

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA　23　(1)　158-63　2015年1月

DOI： 10.1007/s00167-014-2939-z 　

ISSN：0942-2056

eISSN：1433-7347
硬膜内髄外腫瘍との鑑別が問題となるidiopathic hypertrophic pachymeningitisの1例

品川清嗣, 小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 園淵和明, 井樋栄二

東日本整形災害外科学会雑誌　26　(3)　408-408　2014年8月
出版者・発行元：東日本整形災害外科学会
ISSN：1342-7784

eISSN：2433-569X
脊柱後彎症に対する新しい股装具の開発

小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 井樋栄二

運動器リハビリテーション　25　(2)　187-187　2014年6月
出版者・発行元：日本運動器科学会
ISSN：2187-8420
腰椎変性すべり症に対する開窓術の限界同一椎間再手術例の検討

相澤俊峰, 小澤浩司, 橋本功, 菅野晴夫, 両角直樹, 日下部隆, 川原央, 高橋永次, 佐藤哲朗, 国分正一, 井樋栄二

日本整形外科学会雑誌　88　(2)　S181-S181　2014年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
荷重MRIによる腰部脊柱管狭窄の画像診断立位の脊髄造影像における狭窄椎間の同定

菅野晴夫, 小澤浩司, 相澤俊峰, 古泉豊, 両角直樹, 橋本功, 石井祐信, 井樋栄二

日本整形外科学会雑誌　88　(2)　S202-S202　2014年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
頸髄症における術後脊髄腫脹の出現と画像の特徴について

小澤浩司, 佐藤哲朗, 相澤俊峰, 菅野晴夫, 橋本功, 井樋栄二, 国分正一

日本整形外科学会雑誌　88　(3)　S976-S976　2014年3月
出版者・発行元： (公社)日本整形外科学会
ISSN：0021-5325
荷重MRIによる腰部脊柱管狭窄症の画像診断脊髄造影像における狭窄をどこまで捉えるか

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

Journal of Spine Research　5　(3)　436-436　2014年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN：1884-7137

eISSN：2435-1563
Atypical findings on magnetic resonance imaging in the patients with active pyogenic spondylitis in Japanese university hospitals. 査読有り

Toshimi Aizawa, Hiroshi Ozawa, Tomoaki Koakutsu, Takeshi Nakamura, Haruo Kanno, Toru Hirano, Atsuki Sano, Takui Ito, Eiji Itoi

The Tohoku journal of experimental medicine　231　(1)　13-9　2013年9月

DOI： 10.1620/tjem.231.13 　

ISSN：0040-8727

eISSN：1349-3329
Bone formation within the articular cartilage of the lateral compartment of varus osteoarthritic knees. 査読有り

Takehiko Sugita, Toshimi Aizawa, Tomomaro Kawamata, Akira Sasaki, Mitsuhiro Kashiwaba, Atsushi Takahashi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　18　(4)　543-6　2013年7月

DOI： 10.1007/s00776-013-0396-z 　

ISSN：0949-2658
Effect of medial tibial torsion on the sagittal alignment of lower legs in patients with medial knee osteoarthritis. 国際誌査読有り

Atsushi Takahashi, Toshimi Aizawa, Takashi Aki, Mitsuhiro Kashiwaba, Masayuki Kamimura, Shin Hitachi, Eiji Itoi

Surgical and radiologic anatomy : SRA　35　(3)　205-10　2013年4月

DOI： 10.1007/s00276-012-1011-2 　

ISSN：0930-1038 1279-8517
X線診断Q&A 招待有り

相澤俊峰

整形外科　64　73-74　2013年4月1日
Visualization of torn anterior cruciate ligament using 3-dimensional computed tomography. 国際誌査読有り

Hiroaki Uozumi, Toshimi Aizawa, Takehiko Sugita, Tomonori Kunii, Shun Abe, Eiji Itoi

Orthopedic reviews　5　(3)　e22-102　2013年

DOI： 10.4081/or.2013.e22 　

詳細を見る詳細を閉じる

Recently, a remnant-preserving anterior cruciate ligament (ACL) reconstruction technique has been developed. However, the preoperative condition of remnant ACL is occasionally difficult to evaluate by magnetic resonance imaging. The purpose of this study is to evaluate the accuracy of pre-operative visualization of remnant ACL using three-dimensional computed tomography (3D-CT). The remnant ACL in 25 patients was examined by 3DCT before ACL reconstruction surgery. Findings on 3D-CT images and arthroscopy were compared. The 3D-CT images were classified into 4 groups: Group A, remnant fibers attached to the posterior cruciate ligament (PCL); Group B, those located between the PCL and the lateral wall; Group C, those attached to the lateral wall; and Group D, no identifiable remnant fibers on the tibial side. These groups were made up of 4, 3, 9 and 9 patients, respectively. Findings on 3D-CT images were identical to those during arthroscopy in 20 of 25 cases (80%). Remnant ACL can be accurately evaluated using 3D-CT in 80% of cases of torn ACL. This novel method is a useful technique for pre-operative assessment of remnant ACL.
Epidemiology of surgically treated primary spinal cord tumors in Miyagi, Japan. 国際誌査読有り

Hiroshi Ozawa, Toshimi Aizawa, Haruo Kanno, Hirotaka Sano, Eiji Itoi

Neuroepidemiology　41　(3-4)　156-60　2013年

DOI： 10.1159/000353561 　

ISSN：0251-5350 1423-0208
Tumors at the lateral portion of the C1-2 interlaminar space compressing the spinal cord by rotation of the atlantoaxial joint: new aspects of spinal cord compression. 国際誌査読有り

Hiroshi Ozawa, Takashi Kusakabe, Toshimi Aizawa, Takeshi Nakamura, Yushin Ishii, Eiji Itoi

Journal of neurosurgery. Spine　17　(6)　552-5　2012年12月

DOI： 10.3171/2012.9.SPINE12562 　

ISSN：1547-5654
Natural history of intradural-extramedullary spinal cord tumors. 国際誌査読有り

Hiroshi Ozawa, Yoshito Onoda, Toshimi Aizawa, Takeshi Nakamura, Tomoaki Koakutsu, Eiji Itoi

Acta neurologica Belgica　112　(3)　265-70　2012年9月

DOI： 10.1007/s13760-012-0048-7 　

ISSN：0300-9009
Neuroprotective therapy using granulocyte colony-stimulating factor for patients with worsening symptoms of thoracic myelopathy: a multicenter prospective controlled trial. 国際誌

Tsuyoshi Sakuma, Masashi Yamazaki, Akihiko Okawa, Hiroshi Takahashi, Kei Kato, Mitsuhiro Hashimoto, Koichi Hayashi, Takeo Furuya, Takayuki Fujiyoshi, Junko Kawabe, Chikato Mannoji, Tomohiro Miyashita, Ryo Kadota, Yukio Someya, Osamu Ikeda, Tomonori Yamauchi, Masayuki Hashimoto, Toshimi Aizawa, Atsushi Ono, Shiro Imagama, Tokumi Kanemura, Hideki Hanaoka, Kazuhisa Takahashi, Masao Koda

Spine　37　(17)　1475-8　2012年8月1日

eISSN：1528-1159

詳細を見る詳細を閉じる

STUDY DESIGN: An open-labeled multicenter prospective controlled clinical trial. OBJECTIVE: To confirm the feasibility of granulocyte colony-stimulating factor (G-CSF) administration for patients with thoracic myelopathy. SUMMARY OF BACKGROUND DATA: Although G-CSF is best known as an important cytokine commonly used to treat neutropenia, it also has nonhematopoietic functions. Previous experimental studies have shown that G-CSF can enhance tissue regeneration of several organs, such as the heart and the brain. We previously reported that G-CSF promotes functional recovery after spinal cord injury in rodents. On the basis of those findings, we started a clinical trial of neuroprotective therapy, using G-CSF for patients with worsening symptoms of thoracic myelopathy. METHODS: Patients whose Japanese Orthopaedic Association (JOA) score for thoracic myelopathy had decreased 2 points or more during a recent 1-month period were eligible for entry. After giving informed consent, patients were assigned to G-CSF and control groups. The G-CSF group (n = 10) received G-CSF 10 μg/kg per day intravenously for 5 consecutive days. The control group (n = 14) received similar treatments as the G-CSF group except for G-CSF administration. The primary outcome was JOA recovery rate at 1 month after G-CSF administration or initial treatment. RESULTS: There was greater improvement in neurological functioning between baseline and 1-month follow-up in the G-CSF group (JOA recovery rate: 29.1 ± 20.5%) than in the control group (JOA recovery rate: 1.1 ± 4.2%) (P < 0.01). No serious adverse events occurred during or after the G-CSF administration. CONCLUSION: The results provide evidence that G-CSF administration caused neurological recovery in patients with worsening symptoms of thoracic compression myelopathy.
Response to the editorial comments by Dr. Vincent C. Traynelis on the article entitled “Spine-Shortening Osteotomy for Patients with Tethered Cord Syndrome Caused by Lipomyelomeningocele.” 査読有り

Kokubun S Aizawa T

J Neurosurg Spine　15　19-20　2012年7月
Prevalence of reoperation for perioperative complications in lumbar spinal surgery. 招待有り査読有り

Aizawa T Ozawa, H, Kusakabe, T, Nakamura T, Sekiguchi A, Koakutsu, T, Takahashi, K Morozumi, N, Koizumi Y, Itoi E

J Spine Res　3　149-153　2012年7月
Dynamic changes in the dural Sac cross-sectional area on axial loaded MR imaging: Is there a difference between degenerative spondylolisthesis and spinal stenosis? 査読有り

H. Ozawa, Haruo Kanno, Y. Koizumi, N. Morozumi, T. Aizawa, T. Kusakabe, Y. Ishii, E. Itoi

American Journal of Neuroradiology　33　(6)　1191-1197　2012年6月

DOI： 10.3174/ajnr.A2920 　

ISSN：0195-6108 1936-959X
Osteochondritis dissecans of the knee in identical twins: a report of two cases. 国際誌査読有り

Satsuki Onoda, Takehiko Sugita, Toshimi Aizawa, Masahiro Ohnuma, Atsushi Takahashi

Journal of orthopaedic surgery (Hong Kong)　20　(1)　108-10　2012年4月

ISSN：1022-5536

eISSN：2309-4990
Reoperation for recurrent lumbar disc herniation: a study over a 20-year period in a Japanese population. 査読有り

Toshimi Aizawa, Hiroshi Ozawa, Takashi Kusakabe, Takeshi Nakamura, Akira Sekiguchi, Atsushi Takahashi, Tatsuro Sasaji, Shigeyuki Tokunaga, Tomonori Chiba, Naoki Morozumi, Yutaka Koizumi, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　17　(2)　107-13　2012年3月

DOI： 10.1007/s00776-011-0184-6 　

ISSN：0949-2658
Dynamic change of dural sac cross-sectional area in axial loaded magnetic resonance imaging correlates with the severity of clinical symptoms in patients with lumbar spinal canal stenosis. 国際誌査読有り

Haruo Kanno, Hiroshi Ozawa, Yutaka Koizumi, Naoki Morozumi, Toshimi Aizawa, Takashi Kusakabe, Yushin Ishii, Eiji Itoi

Spine　37　(3)　207-13　2012年2月1日

DOI： 10.1097/BRS.0b013e3182134e73 　

ISSN：0362-2436

eISSN：1528-1159
Fracture and contralateral dislocation of the twin facet joints of the lower cervical spine. 国際誌査読有り

Ly Minh Ngo, Toshimi Aizawa, Takeshi Hoshikawa, Yasuhisa Tanaka, Tetsuro Sato, Yushin Ishii, Shoichi Kokubun

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　21　(2)　282-8　2012年2月

DOI： 10.1007/s00586-011-1956-6 　

ISSN：0940-6719
Remodeling capacity of malunited odontoid process fractures in kyphotic angulation in infancy: an observation up to maturity in three patients. 国際誌査読有り

Shigeyuki Tokunaga, Yushin Ishii, Toshimi Aizawa, Yutaka Koizumi, Jun Kawai, Shoichi Kokubun

Spine　36　(23)　E1515-8-E1518　2011年11月1日

DOI： 10.1097/BRS.0b013e31820f6da6 　

ISSN：0362-2436
Incidence of medial plica in 3,889 knee joints in the Japanese population. 国際誌査読有り

Akari Nakayama, Takehiko Sugita, Toshimi Aizawa, Atsushi Takahashi, Tetsuo Honma

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association　27　(11)　1523-7　2011年11月

DOI： 10.1016/j.arthro.2011.06.022 　

ISSN：0749-8063
最近の知見、新たな疾患概念の画像所見―脊髄ヘルニア招待有り

相澤俊峰, 小澤浩司, 日下部隆, 中村豪, 井樋栄二

脊椎脊髄　23　447-450　2011年10月
腰部脊柱管狭窄症の膀胱機能評価―JOAスコアと国際前立腺肥大症状スコア、尿流動態検査との比較. 査読有り

高橋康平, 神尾一彦, 相澤俊峰, 佐藤信, 中川晴彦, 松下真史

整形災害外科　53　179-185　2011年10月
環軸関節回旋により脊髄圧迫が生じたC2神経根腫瘍―2例報告査読有り

日下部隆, 小澤浩司, 相澤俊峰, 中村豪, 石井祐信, 井樋栄二

東日本整災会誌　22　125-130　2011年10月
仙腸関節障害に伴う下肢症状査読有り

村上栄一, 野口京子, 黒澤大輔, 相澤俊峰

臨床整形外科　45　711-714　2011年10月

DOI： 10.11477/mf.1408101777 　
腰部脊柱管狭窄症の膀胱機能評価―JOAスコアと国際前立腺肥大症状スコア、尿流動態検査との比較査読有り

高橋康平, 神尾一彦, 相澤俊峰, 佐藤信, 中川晴彦, 松下真史

整形災害外科　53　179-185　2011年10月
Can the fragment stability of osteochondritis dissecans be interpreted by arthroscopic findings alone? 国際誌査読有り

Takehiko Sugita, Toshimi Aizawa, Hiroaki Uozumi

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association　27　(9)　1171-2　2011年9月

DOI： 10.1016/j.arthro.2011.06.039 　

ISSN：0749-8063
Response 査読有り

Shoichi Kokubun, Toshimi Aizawa

Journal of Neurosurgery: Spine　15　(1)　20　2011年7月

DOI： 10.3171/2010.12.SPINE10725 　

ISSN：1547-5654 1547-5646
Spine-shortening osteotomy for patients with tethered cord syndrome caused by lipomyelomeningocele 査読有り

Shoichi Kokubun, Hiroshi Ozawa, Toshimi Aizawa, Ngo Minh Ly, Yasuhisa Tanaka

JOURNAL OF NEUROSURGERY-SPINE　15　(1)　21-27　2011年7月

DOI： 10.3171/2011.2.SPINE10114 　

ISSN：1547-5654

eISSN：1547-5646
Response to the editorial comments by Dr. Vincent C. Traynelis on the article entitled “Spine-Shortening Osteotomy for Patients with Tethered Cord Syndrome Caused by Lipomyelomeningocele.” 査読有り

Kokubun S Aizawa T

J Neurosurg Spine　15　19-20　2011年7月
骨組織球症―臨床・画像上の特徴と悪性腫瘍との鑑別― 査読有り

保坂正美, 羽鳥正仁, 常陸真, 綿貫宗則, 相澤俊峰, 井樋栄二

整形災害外科　54　1159-1170　2011年7月
Spine-shortening osteotomy for patients with tethered cord syndrome caused by lipomyelomeningocele. 国際誌査読有り

Shoichi Kokubun, Hiroshi Ozawa, Toshimi Aizawa, Ngo Minh Ly, Yasuhisa Tanaka

Journal of neurosurgery. Spine　15　(1)　21-7　2011年7月

DOI： 10.3171/2011.2.SPINE10114 　

ISSN：1547-5654

eISSN：1547-5646
Bony island within the articular cartilage of the knee in a child: a rare condition for early osteoarthritis. 国際誌査読有り

Taku Hatta, Takehiko Sugita, Toshimi Aizawa, Masahiro Ohnuma, Atsushi Takahashi, Eiji Itoi

Orthopedic reviews　3　(1)　e7-29　2011年3月17日

DOI： 10.4081/or.2011.e7 　

詳細を見る詳細を閉じる

Articular cartilage is a specific type of connective tissue composed of hydrated proteoglycans within a matrix of collagen fibrils. In the elderly population, it shows degenerative changes that may results in osteoarthritis. The more severe form of osteoarthritis occasionally demonstrates bone formation within the cartilage, which is designated as a bony protuberance, however, such lesions are rare in children. This report presents the case of a 10-year-old boy with a bony protuberance within the articular cartilage of the knee. The patient initially complained of knee pain and he subsequently developed flexion contracture. Radiological and arthroscopic examinations revealed a bony protuberance in the articular cartilage and degenerative changes of the cartilage above it. He was successfully treated by the removal of the bony protuberance and osteochondral grafting. The bony protuberance may have caused cartilage degradation since the thickness of the cartilage above it was thinner than that around the lesion. The bony protuberance within the articular cartilage formed in the younger population may be a possible cause of osteoarthritis. This case is a noteworthy with regard to the pathogenesis of osteoarthritis.
腰部脊柱管狭窄症の膀胱機能評価―JOAスコアと国際前立腺肥大症状スコア、尿流動態検査との比較査読有り

高橋康平, 神尾一彦, 相澤俊峰, 佐藤信, 中川晴彦, 松下真史

整形災害外科　53　179-185　2010年11月
環軸関節回旋により脊髄圧迫が生じたC2神経根腫瘍―2例報告査読有り

日下部隆, 小澤浩司, 相澤俊峰, 中村豪, 石井祐信, 井樋栄二

東日本整災会誌　22　125-130　2010年10月
仙腸関節障害に伴う下肢症状査読有り

村上栄一, 野口京子, 黒澤大輔, 相澤俊峰

臨床整形外科　45　711-714　2010年10月

DOI： 10.11477/mf.1408101777 　
脊椎巨細胞腫12例の検討査読有り

関口玲, 小澤浩司, 相澤俊峰, 日下部隆, 中村豪, 保坂正美, 井樋栄二

東日本整形災害外科学会雑誌　22　(3)　466-466　2010年8月
原発性脊椎腫瘍の手術成績査読有り

山屋誠司, 小澤浩司, 相澤俊峰, 日下部隆, 中村豪, 関口玲, 保坂正美, 井樋栄二

東日本整形災害外科学会雑誌　22　(3)　465-465　2010年8月
傍脊柱筋・大腰筋における脊柱支持機能の比較査読有り

富谷明人, リチャード・リーバー, 相澤俊峰, 井樋栄二

日本整形外科スポーツ医学会雑誌　30　(4)　387-387　2010年8月
C1/2 facet cyst revealed by facet joint arthrography. 査読有り

Toshimi Aizawa, Hiroshi Ozawa, Takashi Kusakabe, Takeshi Nakamura, Pongsthorn Chanplakorn, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　15　(4)　603-7　2010年7月

DOI： 10.1007/s00776-009-1472-2 　

ISSN：0949-2658
最近の知見、新たな疾患概念の画像所見―脊髄ヘルニア招待有り

相澤俊峰, 小澤浩司, 日下部隆, 中村豪, 井樋栄二

脊椎脊髄　23　447-450　2010年6月
Clinical significance of intramedullary Gd-DTPA enhancement in cervical myelopathy. 査読有り

Ozawa H, Sato T, Hyodo H, Ishii Y, Morozumi N, Koizumi Y, Matsumoto F, Kasama F, Aizawa T, Itoi E, Kokubun S

Spinal Cord　48　(5)　415-422　2010年5月

DOI： 10.1038/sc.2009.152 　
Giant sacral schwannoma: a report of six cases. 国際誌査読有り

Chanplakorn Pongsthorn, Hiroshi Ozawa, Toshimi Aizawa, Takashi Kusakabe, Takeshi Nakamura, Eiji Itoi

Upsala journal of medical sciences　115　(2)　146-52　2010年5月

DOI： 10.3109/03009730903359674 　

ISSN：0300-9734
Incidence of complications associated with spinal endoscopic surgery: nationwide survey in 2007 by the Committee on Spinal Endoscopic Surgical Skill Qualification of Japanese Orthopaedic Association. 招待有り査読有り

Morio Matsumoto, Toru Hasegawa, Manabu Ito, Toshimi Aizawa, Shinichi Konno, Masatsune Yamagata, Sohei Ebara, Yudo Hachiya, Hiroaki Nakamura, Shoji Yagi, Kimiaki Sato, Akira Dezawa, Muneto Yoshida, Kenichi Shinomiya, Yoshiaki Toyama, Katsuji Shimizu, Kensei Nagata

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　15　(1)　92-6　2010年1月

DOI： 10.1007/s00776-009-1428-6 　

ISSN：0949-2658
Comparison of cervical spinal canal diameter between younger and elder generations of Japanese. 査読有り

Shin-ichi Goto, Jutaro Umehara, Toshimi Aizawa, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　15　(1)　97-103　2010年1月

DOI： 10.1007/s00776-009-1427-7 　

ISSN：0949-2658
Histologic findings and possible causes of osteochondritis dissecans of the knee. 国際誌査読有り

Hiroaki Uozumi, Takehiko Sugita, Toshimi Aizawa, Atsushi Takahashi, Masahiro Ohnuma, Eiji Itoi

The American journal of sports medicine　37　(10)　2003-8　2009年10月

DOI： 10.1177/0363546509346542 　

ISSN：0363-5465
脊椎内視鏡下手術の現状ー2007年1月〜12月手術施行状況調査・インシデント報告集計結果ー. 査読有り

松本守雄, 長谷川徹, 相澤俊峰, 猪川輪哉, 伊東学, 江原宗平, 岡治道, 加藤圭彦, 川上守, 川原範夫, 古賀公明, 紺野慎一, 西良浩一, 坂本直俊, 佐藤公治, 佐藤公昭, 高野裕一, 高橋誠, 田中雅人, 出沢明, 中野恵介, 中村博亮, 夏山元伸, 長谷川和宏, 蜂谷裕道, 平泉裕, 藤本吉範, 前川慎吾, 前田健, 松本守雄, 三上靖夫, 望月眞人, 八木省次, 山縣正庸, 山元拓哉, 湯澤洋平, 清水克時, 四宮謙一, 戸山芳昭, 吉田宗人

日本整形外科学会雑誌　83　56-61　2009年10月
胸部脊髄症の現況招待有り

佐藤哲朗, 相澤俊峰

脊椎脊髄ジャーナル　22　136-141　2009年10月
脊椎内視鏡下手術の現状-2008年1月〜12月手術施行状況調査・インシデント報告集計結果- 査読有り

松本守雄, 長谷川徹, 伊藤学, 相澤俊峰, 紺野慎一, 山縣正庸, 江原宗平, 蜂谷裕道, 中村博亮, 八木省次, 佐藤公昭, 出沢明, 吉田宗人, 戸山芳昭, 清水克時, 永田見生

日本整形外科学会雑誌　83　1022-1027　2009年10月
離断性骨軟骨炎に対する組織学的検討査読有り

高橋敦, 相澤俊峰, 大沼正宏, 井樋栄二, 杉田健彦, 魚住弘明, 田代茂義

東北膝関節研究会会誌　19　53-57　2009年10月
Facet cyst hematoma in the lumbar spine: hematoma produced by bleeding into a pre-existing juxtafacet cyst. 査読有り

Miyatake N Aizawa T, Hyodo, H, Sasaki H, Kusakabe, T, Sato T

J Orthop Surg　17　80-84　2009年4月1日
T1 radiculopathy caused by intervertebral disc herniation: symptomatic and neurological features. 査読有り

Haruo Kanno, Toshimi Aizawa, Yasuhisa Tanaka, Takeshi Hoshikawa, Hiroshi Ozawa, Eiji Itoi, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　14　(1)　103-6　2009年1月

DOI： 10.1007/s00776-008-1276-9 　

ISSN：0949-2658
Severe facet joint arthrosis caused c7/t1 myelopathy: a case report. 国際誌査読有り

Toshimi Aizawa, Hiroshi Ozawa, Takeshi Hoshikawa, Takashi Kusakabe, Eiji Itoi

Case reports in medicine　2009　481459-481459　2009年

DOI： 10.1155/2009/481459 　

詳細を見る詳細を閉じる

Cervical myelopathy is caused by degenerative processes of the spine including intervertebral disc herniation and posterior spur usually developing at C3/4 to C5/6. C7/T1 single level myelopathy is very rare because of the anatomical characteristics. Facet joint arthrosis can be a cause of cervical myelopathy but only a few cases have been reported. The authors report an extremely rare case of C7/T1 myelopathy caused by facet joint arthrosis. A 58-year-old male presented with hand and gait clumsiness. The radiological examinations revealed severe C7/T1 facet joint arthrosis with bony spur extending into the spinal canal, which compressed the spinal cord laterally. The T1 spinous process indicated nonunion of a "clay-shoveler's" fracture, which suggested that his cervico-thoracic spine had been frequently moved, and thus severe arthrosis had occurred in the facet joints. A right hemilaminectomy of C7 and C7/T1 facetectomy with single level spinal fusion led to complete neurological improvement.
Diagram specific to sacroiliac joint pain site indicated by one-finger test. 査読有り

Eiichi Murakami, Toshimi Aizawa, Kyoko Noguchi, Haruo Kanno, Hiroshi Okuno, Hiroaki Uozumi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　13　(6)　492-7　2008年11月
出版者・発行元： Springer Japan
DOI： 10.1007/s00776-008-1280-0 　

ISSN：0949-2658
黄色靭帯骨化による胸部脊髄症招待有り

相澤俊峰

整形外科　59　1277-1280　2008年9月
Spine-shortening vertebral osteotomy in a patient with tethered cord syndrome and a vertebral fracture. Case report. 国際誌査読有り

Haruo Kanno, Toshimi Aizawa, Hiroshi Ozawa, Takeshi Hoshikawa, Eiji Itoi, Shoichi Kokubun

Journal of neurosurgery. Spine　9　(1)　62-6　2008年7月

DOI： 10.3171/SPI/2008/9/7/062 　

ISSN：1547-5654
Sagittal alignment changes after thoracic laminectomy in adults. 国際誌査読有り

Toshimi Aizawa, Tetsuro Sato, Hiroshi Ozawa, Naoki Morozumi, Fujio Matsumoto, Hirotoshi Sasaki, Takeshi Hoshikawa, Chikashi Kawahara, Shoichi Kokubun, Eiji Itoi

Journal of neurosurgery. Spine　8　(6)　510-6　2008年6月

DOI： 10.3171/SPI/2008/8/6/510 　

ISSN：1547-5654
Normal bone growth requires optimal estrogen levels: negative effects of both high and low dose estrogen on the number of growth plate chondrocytes. 査読有り

Hiroyuki Takano, Toshimi Aizawa, Taichi Irie, Eiji Itoi, Shoichi Kokubun, Helmtrud I Roach

The Tohoku journal of experimental medicine　214　(3)　269-80　2008年3月

DOI： 10.1620/tjem.214.269 　

ISSN：0040-8727

eISSN：1349-3329
腰部脊柱管狭窄症における荷重MRIの検討. 査読有り

菅野晴夫, 小澤浩司, 相澤俊峰, 星川健, 川原央, 井樋栄二

東日本整災誌　20　(1)　60-64　2008年

ISSN：1342-7784
Response to the letter from Dr. Kong and Wang. 査読有り

Aizawa T, Sato T, J Neurosurg

J Neurosurg (spine)　6　377-378　2007年12月
Crowned Dens syndrome. 国際誌査読有り

Shinichi Goto, Jutaro Umehara, Toshimi Aizawa, Shoichi Kokubun

The Journal of bone and joint surgery. American volume　89　(12)　2732-6　2007年12月

DOI： 10.2106/JBJS.F01322 　

ISSN：0021-9355

eISSN：1535-1386
Spinal dumbbell tumors: an analysis of a series of 118 cases. 国際誌査読有り

Hiroshi Ozawa, Shoichi Kokubun, Toshimi Aizawa, Takeshi Hoshikawa, Chikashi Kawahara

Journal of neurosurgery. Spine　7　(6)　587-93　2007年12月

DOI： 10.3171/SPI-07/12/587 　

ISSN：1547-5654
慢性仙腸関節性疼痛に対する仙腸関節前方固定術査読有り

村上栄一, 菅野晴夫, 相澤俊峰, 奥野洋史, 野口京子

日本腰痛会誌　13　(1)　197-203　2007年11月
出版者・発行元：日本腰痛学会
DOI： 10.3753/yotsu.13.197 　

ISSN：1345-9074

詳細を見る詳細を閉じる

仙腸関節ブロックや骨盤ベルトなどの保存療法の効果が持続せず，日常生活や就労に著しい障害のある仙腸関節性疼痛例に対して仙腸関節前方固定術を行った．男6例，女9例の15例で，年齢は平均49歳（30～86歳），罹病期間は平均3.9年（1～7年），術後経過期間は平均2.3年（6カ月～5年）であった．片側前方固定術を14例に，両側固定術（骨盤輪固定術）を1例に施行した．これらの症例について，関節癒合をCTで，また臨床症状をJOAスコア，VASによる疼痛の変化，Roland-Morris disability questionnaire（RDQ）で評価した．関節癒合は15例全例で得られていた．JOAスコアが術前平均5.6点（4～9点）から術後平均18点（7～24点）に，VASが84（70～93）から40（10～75）に，RDQ得点が21.1（17～23）から6.9（1～14）に改善した．仙腸関節前方固定術の成績は良好であり，保存療法に抵抗する症例には有効な治療法と考えられる．
下垂手（drop finger）をきたす頚部神経根症. 査読有り

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

臨整外　39　475-480　2007年10月
Results of surgical treatment for thoracic myelopathy: minimum 2-year follow-up study in 132 patients. 国際誌査読有り

Toshimi Aizawa, Tetsuro Sato, Hirotoshi Sasaki, Fujio Matsumoto, Naoki Morozumi, Takashi Kusakabe, Eiji Itoi, Shoichi Kokubun

Journal of neurosurgery. Spine　7　(1)　13-20　2007年7月

DOI： 10.3171/SPI-07/07/013 　

ISSN：1547-5654
Estrogen deficiency leads to decrease in chondrocyte numbers in the rabbit growth plate. 査読有り

Hiroyuki Takano, Toshimi Aizawa, Taichi Irie, Shoichi Kokubun, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　12　(4)　366-74　2007年7月

DOI： 10.1007/s00776-007-1145-y 　

ISSN：0949-2658
Effect of periarticular and intraarticular lidocaine injections for sacroiliac joint pain: prospective comparative study. 査読有り

Eiichi Murakami, Yasuhisa Tanaka, Toshimi Aizawa, Masato Ishizuka, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　12　(3)　274-80　2007年5月

DOI： 10.1007/s00776-007-1126-1 　

ISSN：0949-2658
医療費からみた内視鏡下腰椎椎間板ヘルニア摘出術の評価査読有り

相澤俊峰, 佐々木祐肇, 佐藤哲朗

整形外科　58　217-219　2007年4月
Ki-67標識率による脊髄神経鞘腫の増殖能の検討査読有り

小澤浩司, 渡辺みか, 菅野晴夫, 川原央, 星川健, 相澤俊峰

日本脊椎脊髄病学会雑誌　18　(2)　559-559　2007年3月
Effect of resting interval for muscle regeneration in mice. 国際誌査読有り

Aizawa Sasaki, Toshimi Aizawa, Akihito Tomiya, Yoshihiro Matsubara, Shoichi Kokubun, Eiji Itoi

Upsala journal of medical sciences　112　(2)　175-81　2007年

ISSN：0300-9734

eISSN：2000-1967
Thoracic myelopathy caused by ossification of the ligamentum flavum: clinical features and surgical results in the Japanese population. 国際誌査読有り

Toshimi Aizawa, Tetsuro Sato, Hirotoshi Sasaki, Takashi Kusakabe, Naoki Morozumi, Shoichi Kokubun

Journal of neurosurgery. Spine　5　(6)　514-9　2006年12月

DOI： 10.3171/spi.2006.5.6.514 　

ISSN：1547-5654
Facet cyst in the lumbar spine: radiological and histopathological findings and possible pathogenesis. 国際誌査読有り

Takashi Kusakabe, Fumio Kasama, Toshimi Aizawa, Tetsuro Sato, Shoichi Kokubun

Journal of neurosurgery. Spine　5　(5)　398-403　2006年11月

DOI： 10.3171/spi.2006.5.5.398 　

ISSN：1547-5654
Thoracic myelopathy in Japan: epidemiological retrospective study in Miyagi Prefecture during 15 years. 査読有り

Toshimi Aizawa, Tetsuro Sato, Yasuhisa Tanaka, Hiroshi Ozawa, Takeshi Hoshikawa, Yushin Ishii, Naoki Morozumi, Kentaro Ishibashi, Fumio Kasama, Hironori Hyodo, Eiichi Murakami, Takeshi Nishihira, Shoichi Kokubun

The Tohoku journal of experimental medicine　210　(3)　199-208　2006年11月
出版者・発行元： Tohoku University Medical Press
DOI： 10.1620/tjem.210.199 　

ISSN：0040-8727
One-stage lateral rhachotomy and posterior spinal fusion with compression hooks for Pott’s paralysis in the elderly. 査読有り

Wang B Ozawa, H, Tanaka Y, Matsumoto, F Aizawa T, Kokubun S

J Orthop Surg.　14　310-314　2006年10月
日本整形外科学会脊椎内視鏡下手術・技術認定制度委員会: 日本の内視鏡下手術技術認定制度と脊椎内視鏡下手術の現状. 査読有り

谷川徹, 相澤俊峰, 猪川輪哉, 伊東学, 江原宗平, 岡治道, 加藤真介, 加藤圭彦, 川上守, 川原範夫, 古賀公明, 紺野慎一, 坂本直俊, 佐藤公治, 佐藤公昭, 高野裕一, 高橋誠, 田中雅人, 出沢明, 中野恵介, 中村博亮, 夏山元伸, 長谷川和宏, 蜂谷裕道, 平泉裕, 藤本吉範, 前川慎吾, 前田健, 松本守雄, 三上靖夫, 望月眞人, 八木省次, 山縣正庸, 山元拓哉, 湯澤洋平, 吉田宗人, 四宮謙一, 戸山芳昭

日整会誌　80　754-761　2006年10月
脊髄ヘルニアと脊髄嚢腫性病変の治療戦略ー方針決定に必要な情報とその提供ー. 招待有り査読有り

相澤俊峰, 田中靖久, 星川健, 日下部隆, 中條悟, 国分正一

脊椎脊髄ジャーナル　19　717-724　2006年10月
Surgery for ossification of the ligamentum flavum 査読有り

Yasuhisa Tanaka, Tetsuro Sato, Toshimi Aizawa

OPLL: Ossification of the Posterior Longitudinal Ligament　265-269　2006年
出版者・発行元： Springer Japan
DOI： 10.1007/978-4-431-32563-5_37 　
Lumbar discal cyst followed by intervertebral disc herniation: MRI findings of two cases. 査読有り

Masako Tokunaga, Toshimi Aizawa, Hironori Hyodo, Hirotoshi Sasaki, Yasuhisa Tanaka, Tetsuro Sato

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　11　(1)　81-4　2006年1月

DOI： 10.1007/s00776-005-0961-1 　

ISSN：0949-2658
筋性斜頚成長終了例と胸鎖乳突筋筋腹切離術. 査読有り

星川健, 国分正一, 相澤俊峰, 田中靖久, 北純

整形災害外科　48　233-239　2005年10月
脊髄係留症候群に対する脊柱短縮術. 査読有り

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

臨整外　40　633-637　2005年10月

DOI： 10.11477/mf.1408100118 　
The role of sex hormones in the kinetics of chondrocytes in the growth plate - A study in the rabbit 査読有り

T Irie, T Aizawa, S Kokubun

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME　87B　(9)　1278-1284　2005年9月

DOI： 10.1302/0301-620X.87B9.15583 　

ISSN：0301-620X
Signal intensity changes on MRI during the healing process of spinal Langerhans cell granulomatosis: report of two cases. 国際誌査読有り

Toshimi Aizawa, Tetsuro Sato, Yasuhisa Tanaka, Shoichi Kokubun

Journal of spinal disorders & techniques　18　(1)　98-101　2005年2月

DOI： 10.1097/01.bsd.0000112040.70321.c1 　

ISSN：1536-0652
Gorham disease of the spine: a case report and treatment strategies for this enigmatic bone disease. 査読有り

Toshimi Aizawa, Tetsuro Sato, Shoichi Kokubun

The Tohoku journal of experimental medicine　205　(2)　187-96　2005年2月

DOI： 10.1620/tjem.205.187 　

ISSN：0040-8727
下垂手（drop finger）をきたす頚部神経根症. 査読有り

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

臨整外　39　475-480　2004年10月

DOI： 10.11477/mf.1408100419 　
Kummell病に対する後方進入脊柱短縮術. 査読有り

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

日整会誌　78　265-269　2004年10月
Myofibers express IL-6 after eccentric exercise 査読有り

A Tomiya, T Aizawa, R Nagatomi, H Sensui, S Kokubun

AMERICAN JOURNAL OF SPORTS MEDICINE　32　(2)　503-508　2004年3月

DOI： 10.1177/0095399703258788 　

ISSN：0363-5465
Myofibers express IL-6 after eccentric exercise. 国際誌査読有り

Akihito Tomiya, Toshimi Aizawa, Ryoichi Nagatomi, Hiroomi Sensui, Shoichi Kokubun

The American journal of sports medicine　32　(2)　503-8　2004年3月

DOI： 10.1177/0095399703258788 　

ISSN：0363-5465
Impaired fracture healing in the absence of TNF-alpha signaling: The role of TNF-alpha in endochondral cartilage resorption 査読有り

LC Gerstenfeld, TJ Cho, T Kon, T Aizawa, A Tsay, J Fitch, GL Barnes, DT Graves, TA Einhorn

JOURNAL OF BONE AND MINERAL RESEARCH　18　(9)　1584-1592　2003年9月

DOI： 10.1359/jbmr.2003.18.9.1584 　

ISSN：0884-0431
Successful treatment for rhabdomyosarcoma by total spondylectomy in a child. 査読有り

Takeshi Saito, Toshimi Aizawa, Osamu Kashimoto, Tetsuro Sato, Shoichi Kokubun

The Tohoku journal of experimental medicine　198　(4)　251-8　2002年12月

DOI： 10.1620/tjem.198.251 　

ISSN：0040-8727

eISSN：1349-3329
終糸発生傍神経節腫の一例査読有り

渡辺みか, 相澤俊峰, 森谷卓也, 笹野公伸

日本内分泌学会雑誌　78　(2)　494-494　2002年9月
Intramedullary plasma cell granuloma in the cervicothoracic spine. Case report. 国際誌査読有り

Toshimi Aizawa, Tetsuro Sato, Yasuhisa Tanaka, Koshi Kishimoto, Mika Watanabe, Shoichi Kokubun

Journal of neurosurgery　97　(2 Suppl)　235-8　2002年9月

ISSN：0022-3085
Medial superior cluneal nerve entrapment neuropathy in teenagers: a report of two cases. 査読有り

Tarek A Aly, Yasuhisa Tanaka, Toshimi Aizawa, Hiroshi Ozawa, Shoichi Kokubun

The Tohoku journal of experimental medicine　197　(4)　229-31　2002年8月

DOI： 10.1620/tjem.197.229 　

ISSN：0040-8727

eISSN：1349-3329
Idiopathic herniation of the thoracic spinal cord: report of three cases. 査読有り

Aizawa T, Sato T, Tanaka Y, Kotajima S, Sekiya M, Kokubun S

Spine　26　(20)　E488-91　2001年10月15日
Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha 査読有り

T Aizawa, T Kon, TA Einhorn, LC Gerstenfeld

JOURNAL OF ORTHOPAEDIC RESEARCH　19　(5)　785-796　2001年9月

DOI： 10.1016/S0736-0266(00)00078-4 　

ISSN：0736-0266
髄内形質細胞肉芽腫(Plasma cell granuloma)の1例査読有り

相澤俊峰, 佐藤哲朗, 田仲靖久, 国分正一, 渡辺みか

東北整形災害外科紀要　45　(1)　150-150　2001年6月
Expression of osteoprotegerin, receptor activator of NF-kappa B ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing 査読有り

T Kon, TJ Cho, T Aizawa, M Yamazaki, N Nooh, D Graves, LC Gerstenfeld, TA Einhorn

JOURNAL OF BONE AND MINERAL RESEARCH　16　(6)　1004-1014　2001年6月

ISSN：0884-0431
Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling 査読有り

LC Gerstenfeld, TJ Cho, T Kon, T Aizawa, J Cruceta, BD Graves, TA Einhorn

CELLS TISSUES ORGANS　169　(3)　285-294　2001年

DOI： 10.1159/000047893 　

ISSN：1422-6405
c-Myc protein in the rabbit growth plate - Changes in immunolocalisation with age and possible roles from proliferation to apoptosis 査読有り

T Aizawa, S Kokubun, T Kawamata, Y Tanaka, HI Roach

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME　81B　(5)　921-925　1999年9月

DOI： 10.1302/0301-620X.81B5.9492 　

ISSN：0301-620X
脊髄サルコイドーシスの1例査読有り

古泉豊, 佐藤哲朗, 相澤俊峰, 国分正一, 高橋俊明

東北整形災害外科紀要　42　(2)　277-277　1998年12月
出版者・発行元：東北整形災害外科学会
ISSN：0040-8751
Changes in the expression of Fas, osteonectin and osteocalcin with age in the rabbit growth plate 査読有り

T Aizawa, HI Roach, S Kokubun, Y Tanaka

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME　80B　(5)　880-887　1998年9月

DOI： 10.1302/0301-620X.80B5.8430 　

ISSN：0301-620X
Paraparesis associated with mild congenital kyphoscoliosis in an adult 査読有り

T Sato, S Kokubun, Y Tanaka, T Aizawa

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　183　(4)　303-308　1997年12月

DOI： 10.1620/tjem.183.303 　

ISSN：0040-8727

eISSN：1349-3329
Apoptosis and proliferation of growth plate chondrocytes in rabbits 査読有り

T Aizawa, S Kokubun, Y Tanaka

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME　79B　(3)　483-486　1997年5月

DOI： 10.1302/0301-620X.79B3.7221 　

ISSN：0301-620X
Extradural granulocytic sarcoma of the thoracic spine in acute myelogenous leukemia with 8;21 chromosome translocation 査読有り

T Aizawa, S Kokubun, M Hatori, O Kashimoto, R Ichinohasama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　178　(4)　431-436　1996年4月

DOI： 10.1620/tjem.178.431 　

ISSN：0040-8727

eISSN：1349-3329

︎全件表示 ︎最初の5件までを表示

MISC 178

脊椎外科専門医不在施設における脊椎がんロコモのマネジメント

日下部詢弥, 日下部詢弥, 保坂正美, 鈴木一史, 鈴木一史, 橋本功, 高橋康平, 八幡健一郎, 大野木孝嘉, 相澤俊峰

臨床整形外科　60　(9)　2025年

ISSN： 0557-0433
大腿骨頭壊死症は人工股関節全置換術後の早期合併症率を高めるか?:日本における全国医療費請求データベース調査日本のDPC調査

田中秀達, たら澤邦男, 森優, 栗山恭明, 川又裕輝, 伏見清秀, 藤森研司, 相澤俊峰

日本人工関節学会プログラム・抄録集　55th (CD-ROM)　2025年
高齢者大腿骨頸部骨折に対する人工骨頭置換術と人工股関節置換術の合併症をの比較-日本のDPC研究-

田中秀達, たら澤邦男, 森優, 馬場一慈, 福地英輝, 伏見清秀, 藤森研司, 相澤俊峰

日本人工関節学会プログラム・抄録集　55th (CD-ROM)　2025年
腰椎変性後弯症のゲノムワイド関連解析-東北6大学による多施設共同研究-

橋本功, 長崎正朗, 植野和子, 大橋正幸, 鈴木智人, 菅野晴夫, 渡邉和之, 山部大輔, 森優, 徳永勝士, 相澤俊峰

日本整形外科学会雑誌(CD-ROM)　99　(2)　2025年

ISSN： 0021-5325
Type C1およびC2の大腿骨頭壊死症患者の寛骨臼形態が骨頭圧壊と股関節機能に与える影響に関する後ろ向き調査

川又裕輝, 田中秀達, 馬場一慈, 栗山恭明, 金淵龍一, 福地英輝, 森優, 相澤俊峰

日本整形外科学会雑誌(CD-ROM)　99　(2)　2025年

ISSN： 0021-5325
股関節矢状面アライメントを含む指標であるPFA-(PI-LL)は,腰痛による障害を予測しうる-Spinopelvic-hip mismatchという新しい指標の提案-

藤田涼, 高橋康平, 石川圭佑, 大野木孝嘉, 秋貴史, 馬場一慈, 森優, 橋本功, 相澤俊峰

Journal of Spine Research (Web)　16　(3)　2025年

ISSN： 2435-1563
後弯症の歩行速度と関連する因子-大腰筋角という新たな指標の提案-

石川圭佑, 高橋康平, 関口雄介, 日下部詢也, 大野木孝嘉, 八幡健一郎, 藤田涼, 橋本功, 海老原覚, 小澤浩司, 相澤俊峰

Journal of Spine Research (Web)　15　(3)　2024年

ISSN： 2435-1563
後弯症患者におけるdouble knee actionと体幹前傾の関係

石川圭佑, 高橋康平, 関口雄介, 八幡健一郎, 橋本功, 海老原覚, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌(CD-ROM)　98　(8)　2024年

ISSN： 0021-5325
全身アライメントで考える変形性関節症脊椎後弯症患者の歩行に変形性股関節症が与える影響-脊椎後弯症患者の歩行解析からの予測-

石川圭佑, 石川圭佑, 高橋康平, 相澤俊峰

Monthly Book Orthopaedics　37　(13)　2024年

ISSN： 0914-8124
Stage1・2の大腿骨頭壊死患者の骨形態と骨頭圧潰に関する後ろ向き調査

栗山恭明, 田中秀達, 馬場一慈, 金淵龍一, 森優, 相澤俊峰

日本股関節学会学術集会プログラム・抄録集　51st　2024年
人工股関節全置換術術前の骨粗鬆症治療導入が術後成績に与える影響

金淵龍一, 森優, 馬場一慈, 田中秀達, 栗山恭明, 畠山拡, 川又裕輝, 福地英輝, 相澤俊峰

日本股関節学会学術集会プログラム・抄録集　51st　2024年
腸骨大腿靭帯を含む股関節包切開方向が股関節安定性に与える影響の検討-新鮮凍結屍体を用いて

田中秀達, 馬場一慈, 金淵龍一, 栗山恭明, 森優, 相澤俊峰

日本股関節学会学術集会プログラム・抄録集　51st　2024年
骨折の有無で比較検討した骨粗鬆症治療中の関節リウマチ患者の特徴

泉山拓也, 森優, 金淵龍一, 相澤俊峰

日本骨粗鬆症学会雑誌　10　(Suppl.1 (CD-ROM))　2024年

ISSN： 2189-8383
Latarjet法の治療成績向上のための私の工夫

山本宣幸, 鯉淵優介, 佐々木一真, 有野敦司, 木村礼, 永元英明, 永元英明, 相澤俊峰

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　51st-21st　2024年
逆Hill-Sachs損傷の手術適応-逆関節窩軌跡の提唱-

石津敦玄, 山本宣幸, 鯉淵優介, 佐々木一真, 有野敦司, 木村礼, 川上純, 長友英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　51st-21st　2024年
鏡視下Bankart修復術の平均10年の術後成績

菅原渉瑚, 山本宣幸, 鯉淵優介, 佐々木一真, 有野敦司, 木村礼, 川上純, 永元英明, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　51st-21st　2024年
ImageJを用いた腱板脂肪変化の新しい定量化手法の提案

有野敦司, 山本宣幸, 鯉淵優介, 佐々木一真, 木村礼, 永元英明, 相澤俊峰

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　51st-21st　2024年
近軌跡損傷(near track lesion)は辺縁軌跡損傷を過大評価する

鯉淵優介, 山本宣幸, 佐々木一真, 有野敦司, 木村礼, 川上純, 永元英明, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　51st-21st　2024年
肩脱臼時に下関節上腕靱帯は20%伸びる

木村礼, 山本宣幸, 鯉淵優介, 佐々木一真, 有野敦司, 川上純, 永元英明, 永元英明, 相澤俊峰

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　51st-21st　2024年
当院で行われた反転型人工肩関節置換術の術後合併症

佐々木一真, 山本宣幸, 鯉淵優介, 有野敦司, 木村礼, 川上純, 永元英明, 永元英明, 相澤俊峰

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　51st-21st　2024年
肩関節痛患者に合併する神経障害性疼痛の頻度 - PainDETECTを用いた調査 -

佐々木一真, 山本宣幸, 有野敦司, 木村礼, 川上純, 永元英明, 永元英明, 相澤俊峰

肩関節(Web)　48　(2)　2024年

ISSN： 1881-6363
東北大学脊椎外科懇話会34年間の脊椎手術全例登録からみた高齢者脊椎手術の疫学的変遷

橋本功, 椿野巧, 川原央, 甲川昌和, 中川智刀, 小川真司, 日下部隆, 高橋永次, 菅野晴夫, 舘田聡, 中村豪, 高橋康平, 山屋誠司, 黒澤大輔, 国分正一, 相澤俊峰

東北整形災害外科学会雑誌　67　(1)　2024年

ISSN： 1348-8694
骨粗鬆症性椎体骨折による神経障害の疫学的特徴-前向き多施設共同研究-

菅野晴夫, 小澤浩司, 橋本功, 高橋康平, 相澤俊峰, 兵藤弘訓, 徳永雅子, 佐藤哲朗, 田中靖久, 中村聡, 両角直樹, 国分正一, 関口玲, 小川真司

東北整形災害外科学会雑誌　67　(1)　2024年

ISSN： 1348-8694
視距離と頭部傾斜角による頚椎アライメントの推定-推定精度に影響を与える因子は何か-

橋本功, 高橋佑生, 高橋康平, 大野木孝嘉, 相澤俊峰

日本整形外科学会雑誌　98　(2)　2024年

ISSN： 0021-5325
胸椎後縦靱帯骨化症に対する後方進入前方除圧術後の麻痺増悪に関する検討

高橋康平, 橋本功, 八幡健一郎, 大野木孝嘉, 菅野晴夫, 小澤浩司, 相澤俊峰

Journal of Spine Research (Web)　15　(5)　2024年

ISSN： 2435-1563
ヒトの直立には脊椎骨盤と股関節の協調が必要である

藤田涼, 高橋康平, 石川圭佑, 大野木孝嘉, 秋貴史, 馬場一慈, 八幡健一郎, 橋本功, 相澤俊峰

日本整形外科学会雑誌　98　(2)　2024年

ISSN： 0021-5325
脊柱変形矯正手術後の体幹前傾遺残には股関節代償機能が影響する

高橋康平, 橋本功, 石川圭佑, 八幡健一郎, 大野木孝嘉, 半田恭一, 菅野晴夫, 中村豪, 小澤浩司, 田中靖久, 相澤俊峰

日本整形外科学会雑誌　98　(3)　2024年

ISSN： 0021-5325
骨粗鬆症性椎体骨折による神経障害の疫学的特徴-多施設前向き研究-

菅野晴夫, 兵藤弘訓, 田中靖久, 中村聡, 橋本功, 両角直樹, 関口玲, 佐藤哲朗, 国分正一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　98　(3)　2024年

ISSN： 0021-5325
腰椎分離部の骨棘により自然発症したと考えられる硬膜損傷・馬尾嵌頓の1例

大野木孝嘉, 高橋康平, 橋本功, 八幡健一郎, 石川圭佑, 日下部詢弥, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　121st　2024年
脊椎専門医不在施設における脊椎がんロコモのマネージメント

日下部詢弥, 日下部詢弥, 鈴木一史, 大野木孝嘉, 八幡健一郎, 高橋康平, 橋本功, 相澤俊峰, 保坂正美

東北整形災害外科学会プログラム・抄録集　121st　2024年
下肢痛の伴わない腰痛を主訴としたBertolotti症候群の4例

千葉美詩央, 高橋康平, 八幡健一郎, 馬場一慈, 大野木孝嘉, 橋本功, 中村豪, 椿野巧, 川原央, 両角直樹, 田中靖久, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　121st　2024年
上位頚椎高位に生じた椎間関節嚢腫

日下部隆, 松谷重恒, 橋本功, 大野木孝嘉, 相澤俊峰

Journal of Spine Research (Web)　15　(3)　2024年

ISSN： 2435-1563
胸椎後縦靱帯骨化症における術後麻痺増悪には術式間で違いがあるか-後方除圧固定術と後方進入前方除圧術の比較-

高橋康平, 橋本功, 八幡健一郎, 大野木孝嘉, 菅野晴夫, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　98　(3)　2024年

ISSN： 0021-5325
Kambinアプローチ全内視鏡下腰椎椎体間固定術術後3年の治療成績と課題:新cage挿入器(Yスライダー)の開発

山屋誠司, 橋本功, 古泉豊, 矢部裕, 小城繁明, 須田英明, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本内視鏡外科学会総会(Web)　37th　2024年
骨粗鬆症性椎体骨折による神経障害の疫学的特徴:前向き多施設共同研究

菅野晴夫, 兵藤弘訓, 田中靖久, 中村聡, 橋本功, 高橋康平, 両角直樹, 関口玲, 徳永雅子, 半田恭一, 佐藤哲朗, 国分正一, 小澤浩司, 相澤俊峰

Journal of Spine Research (Web)　15　(3)　2024年

ISSN： 2435-1563
Kambinアプローチ全内視鏡下腰椎椎体間固定術術後3年の治療成績と課題:新cage挿入器(Yスライダー)の開発

山屋誠司, 橋本功, 古泉豊, 矢部裕, 小城繁明, 須田英明, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本低侵襲脊椎外科学会学術集会プログラム・抄録集　27th　2024年
腰部脊柱管狭窄症に対するUBE/BESS複数ポータル式灌流型内視鏡下椎弓形成術UBEL:CUSUM法を用いたラーニングカーブの検討

山屋誠司, 吉水隆貴, 佐々木寛二, 橋本功, 古泉豊, 矢部裕, 小城繁明, 須田英明, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本低侵襲脊椎外科学会学術集会プログラム・抄録集　27th　2024年
脊椎後弯症患者の立位静止時と歩行時における体幹前傾と股関節肢位の関係

石川圭佑, 関口雄介, 高橋康平, 日下部詢弥, 馬場一慈, 八幡健一郎, 藤田涼, 橋本功, 海老原覚, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　98　(3)　2024年

ISSN： 0021-5325
後弯症において歩行速度と関連する因子は何か-大腰筋角という新たな指標の提案-

石川圭佑, 高橋康平, 関口雄介, 日下部詢弥, 馬場一慈, 八幡健一郎, 藤田涼, 橋本功, 海老原覚, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　98　(3)　2024年

ISSN： 0021-5325
β2ミクログロブリンアミロイドとRAGE関連炎症カスケードが透析患者の黄色靱帯に与える影響

石川圭佑, 矢部裕, 矢部裕, 萩原嘉廣, 萩原嘉廣, 相澤俊峰

日本整形外科学会雑誌　97　(8)　2023年

ISSN： 0021-5325
胸椎後縦靭帯骨化症に対する後方除圧固定術と後方進入前方除圧固定術の比較

渋谷洋平, 渋谷洋平, 大橋正幸, 渡辺慶, 橋本功, 高橋康平, 大野木孝嘉, 相澤俊峰, 菅野晴夫, 小澤浩司, 鈴木智人, 赤羽武

東北整形災害外科学会雑誌　66　(1)　2023年

ISSN： 1348-8694
単一の馬尾から数珠状に多発した神経鞘腫の4例

村上大史, 大野木孝嘉, 石川圭佑, 藤田涼, 高橋康平, 橋本功, 相澤俊峰

東北整形災害外科学会雑誌　66　(1)　2023年

ISSN： 1348-8694
当院における骨転移診療ボードの取り組みとその効果

吉田新一郎, 岩津潤, 大野木孝嘉, 高橋康平, 橋本功, 相澤俊峰, 柳垣聡, 常陸真, 高瀬圭

日本整形外科学会雑誌　97　(3)　2023年

ISSN： 0021-5325
鼡径部痛を伴う仙腸関節障害例での股関節疾患合併頻度

黒澤大輔, 黒澤大輔, 村上栄一, 村上栄一, 野口森幸, 佐々木健, 橋本功, 相澤俊峰

日本整形外科学会雑誌　97　(3)　2023年

ISSN： 0021-5325
重度胸髄症を呈した胸椎後縦靱帯骨化症における後方除圧固定術と後方進入前方除圧固定術の比較-4大学共同研究-

渋谷洋平, 渋谷洋平, 大橋正幸, 橋本功, 高橋康平, 菅野晴夫, 鈴木智人, 赤羽武, 小澤浩司, 相澤俊峰, 渡辺慶, 川島寛之

日本整形外科学会雑誌　97　(2)　2023年

ISSN： 0021-5325
腰椎後弯症患者の立位保持には十分な股関節伸展が必要である

藤田涼, 高橋康平, 石川圭佑, 大野木孝嘉, 秋貴史, 馬場一慈, 菅野晴夫, 橋本功, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　97　(3)　2023年

ISSN： 0021-5325
頭部傾斜角と視距離による脊柱矢状面アライメントの推定-坐位・情報端末作業時の継続的姿勢モニタリングにむけて-

橋本功, 高橋佑生, 高橋康平, 大野木孝嘉, 相澤俊峰

日本整形外科学会雑誌　97　(3)　2023年

ISSN： 0021-5325
脊椎-骨盤ミスマッチに対する股関節代償機能の検討-PI-LLと股関節伸展の関連-

馬場一慈, 高橋康平, 秋貴史, 石川圭佑, 藤田涼, 大野木孝嘉, 橋本功, 相澤俊峰

日本整形外科学会雑誌　97　(3)　2023年

ISSN： 0021-5325
当院における骨転移診療ボードによる臨床面および若手教育面での効果

吉田新一郎, 岩津潤, 大野木孝嘉, 高橋康平, 橋本功, 相澤俊峰, 柳垣聡, 常陸真, 小黒草太, 高瀬圭

日本整形外科学会雑誌　97　(6)　2023年

ISSN： 0021-5325
胸椎後縦靱帯骨化症における後方除圧固定術と後方進入前方除圧固定術の比較-4大学共同研究-

渋谷洋平, 渋谷洋平, 大橋正幸, 橋本功, 高橋康平, 大野木孝嘉, 菅野晴夫, 鈴木智人, 赤羽武, 小澤浩司, 相澤俊峰, 渡辺慶

Journal of Spine Research (Web)　14　(3)　2023年

ISSN： 2435-1563
骨粗鬆症性椎体骨折による神経障害:多施設前向き研究

菅野晴夫, 兵藤弘訓, 徳永雅子, 橋本功, 高橋康平, 田中靖久, 中村聡, 小川真司, 古泉豊, 両角直樹, 関口玲, 相澤俊峰, 小澤浩司, 佐藤哲朗, 国分正一

東北整形災害外科学会プログラム・抄録集　120th　2023年
東北大学脊椎外科懇話会34年間の脊椎手術全例登録からみた脊椎手術の疫学的変遷とこれから

橋本功, 椿野巧, 川原央, 甲川昌和, 中川智刀, 小川真司, 日下部隆, 高橋永次, 菅野晴夫, 舘田聡, 中村豪, 高橋康平, 山屋誠司, 黒澤大輔, 国分正一, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　120th　2023年
頭部傾斜角と視距離による脊柱矢状面アライメントの推定とその精度向上因子-継続的姿勢モニタリングにむけて-

橋本功, 相澤俊峰

東日本整形災害外科学会雑誌(Web)　35　(3)　2023年

ISSN： 2433-569X
データに基づくsacroiliac-spine syndrome

村上栄一, 黒澤大輔, 高田哲史, 橋本功, 相澤俊峰

日本整形外科学会雑誌　97　(8)　2023年

ISSN： 0021-5325
全内視鏡下腰椎椎体間固定術(Full-endoscopic trans-Kambin lumbar interbody fusion:FE-KLIF)-術後3年の治療成績-

山屋誠司, 山屋誠司, 橋本功, 古泉豊, 矢部裕, 須田英明, 千葉美詩央, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本低侵襲脊椎外科学会学術集会プログラム・抄録集　26th　2023年
HIZ,toxic annular tearとModic type1に対する経椎間孔アプローチ全内視鏡下椎間板内治療-椎間板性腰痛,病態別術後成績の比較

山屋誠司, 橋本功, 古泉豊, 矢部裕, 須田英明, 千葉美詩央, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本低侵襲脊椎外科学会学術集会プログラム・抄録集　26th　2023年
頚椎椎弓形成術の新たな低侵襲化

菅野晴夫, 中村聡, 橋本功, 半田恭一, 小澤浩司, 相澤俊峰

日本低侵襲脊椎外科学会学術集会プログラム・抄録集　26th　2023年
腰部脊柱管狭窄症に対する新しい内視鏡下椎弓形成術-UBEL/a-FELとSYNCHA-MELの可能性-

山屋誠司, 橋本功, 古泉豊, 矢部裕, 須田英明, 千葉美詩央, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本低侵襲脊椎外科学会学術集会プログラム・抄録集　26th　2023年
サルコペニアと後弯症:後弯症患者の歩行速度に関与する因子-三次元動作解析装置を用いた歩行解析とレントゲン計測による検討-

石川圭佑, 高橋康平, 関口雄介, 大野木孝嘉, 馬塲一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本骨粗鬆症学会雑誌　9　(Suppl.1 (CD-ROM))　2023年

ISSN： 2189-8383
TiNbSn合金で開発した人工股関節ステムの5年以上経過例の中期成績

千葉大介, 山田則一, 大山正瑞, 大津進, 桑原功行, 馬場一慈, 田中秀達, 花田修治, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(2)　2023年

ISSN： 0021-5325
投球障害肩・肘を有する選手とdeep squat testとの関連性(The relationship between deep squat test and players with disabled throwing shoulder/elbow)

Nagamoto Hideaki, Muraki Takayuki, Abe Masaya, Kimura Rei, Shinagawa Kiyotsugu, Yaguchi Haruki, Kurokawa Daisuke, Takahashi Hiroyuki, Yamamoto Nobuyuki, Aizawa Toshimi, Kumai Tsukasa

日本整形外科学会雑誌　96　(3)　S739-S739　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
投球肩および/あるいは投球肘に障害を有する選手は蹴り足のheel raise testで有意な陽性反応を示す(Players with disabled throwing shoulder and/or elbow show significant positive heel raise test of their kicking leg)

Nagamoto Hideaki, Muraki Takayuki, Abe Masaya, Kimura Rei, Shinagawa Kiyotsugu, Yaguchi Haruki, Kurokawa Daisuke, Takahashi Hiroyuki, Yamamoto Nobuyuki, Aizawa Toshimi, Kumai Tsukasa

日本整形外科学会雑誌　96　(3)　S742-S742　2022年3月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
頚髄症に対する棘突起縦割式椎弓形成術の低侵襲化

菅野晴夫, 中村聡, 橋本功, 高橋康平, 大野木孝嘉, 半田恭一, 小澤浩司, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　119th　2022年
腰椎変性すべり症に対する腰椎後方除圧術に腰椎不安定性が与える影響

那波康隆, 高橋康平, 椿野巧, 星川健, 中川智刀, 中村豪, 三宅公太, 金城英傑, 小城繁明, 橋本功, 相澤俊峰, 田中靖久

Journal of Spine Research (Web)　13　(3)　2022年

ISSN： 2435-1563
前額断MRIによる腰椎椎間孔部狭窄の診断の信頼性と再現性-T1・T2強調画像の信頼性・再現性の比較-

橋本功, 田中靖久, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 古泉豊, 国分正一, 相澤俊峰

Journal of Spine Research (Web)　13　(3)　2022年

ISSN： 2435-1563
Mitochonic acid-5(MA-5)による高齢マウスのサルコペニア抑制効果

阿部高久, 橋本功, 大野木孝嘉, 佐藤宏陽, 芝崎真人, 阿部高明, 相澤俊峰

日本整形外科学会雑誌　96　(8)　2022年

ISSN： 0021-5325
新規化合物mitochonic acid(MA-5)は運動機能と骨格筋ミトコンドリア機能を向上させる

佐藤宏陽, 橋本功, 大野木孝嘉, 阿部高久, 芝崎真人, 相澤俊峰

日本整形外科学会雑誌　96　(8)　2022年

ISSN： 0021-5325
胸椎OPLLに対する弯曲型ドリルとT-sawを用いた新たな後方進入前方除圧-安全かつ確実な除圧が手術成績を向上させる-

菅野晴夫, 橋本功, 高橋康平, 大野木孝嘉, 小澤浩司, 相澤俊峰

日本脊椎インストゥルメンテーション学会抄録集　31st　2022年
脊椎後弯症患者の歩行時の下肢関節肢位-三次元動作解析装置を用いた歩行解析-

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 藤田涼, 大野木孝嘉, 馬塲一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

Journal of Spine Research (Web)　13　(3)　2022年

ISSN： 2435-1563
局所麻酔・意識下,全内視鏡下腰椎手術と合併症回避の意義

山屋誠司, 橋本功, 古泉豊, 鈴木学, 須田英明, 八幡健一郎, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本整形外科学会雑誌　96　(2)　2022年

ISSN： 0021-5325
全内視鏡除圧からKLIF固定まで:教育システムの提言

山屋誠司, 橋本功, 古泉豊, 鈴木学, 須田英明, 八幡健一郎, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本整形外科学会雑誌　96　(2)　2022年

ISSN： 0021-5325
アンドロイドモデルを用いた二足歩行時の仙腸関節面の荷重伝達部位とタイミング

佐中孝二, 黒澤大輔, 村上栄一, 橋本功, 相澤俊峰

整形外科　73　(3)　2022年

ISSN： 0030-5901
仙腸関節固定術後の仙結節靱帯部痛の頻度と経過

黒澤大輔, 黒澤大輔, 佐々木健, 村上栄一, 村上栄一, 橋本功, 相澤俊峰

日本整形外科学会雑誌　96　(3)　2022年

ISSN： 0021-5325
Hip-sacroiliac syndrome(仮称)の検討(FAIS股関節鏡視下手術例)

野口森幸, 村上栄一, 橋本功, 黒澤大輔, 相澤俊峰

日本整形外科学会雑誌　96　(3)　2022年

ISSN： 0021-5325
前額断MRIによる腰椎椎間孔部狭窄の診断の信頼性と再現性-T1・T2強調画像の信頼性・再現性の比較-

橋本功, 橋本功, 田中靖久, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 高橋康平, 鈴木学, 大野木孝嘉, 古泉豊, 国分正一, 相澤俊峰

日本整形外科学会雑誌　96　(3)　2022年

ISSN： 0021-5325
軽微な外傷で生じたアキレス腱部分断裂の一例

佐藤宏陽, 永元英明, 藍澤一穂, 品川清嗣, 相澤俊峰

日本足の外科学会雑誌　42　(Suppl.)　S246-S246　2021年10月
出版者・発行元： (一社)日本足の外科学会
ISSN： 0916-7927
高校生アスリートに対する鏡視下足関節外側靱帯修復術の治療成績

永元英明, 木村礼, 畠英里, 相澤俊峰, 熊井司

日本足の外科学会雑誌　42　(Suppl.)　S346-S346　2021年10月
出版者・発行元： (一社)日本足の外科学会
ISSN： 0916-7927
脊柱靭帯骨化症に関する調査研究胸椎OPLLに対する後方除圧固定術と後方進入前方除圧固定術の術後成績

相澤俊峰, 橋本功, 高橋康平, 半田恭一, 小澤浩司, 菅野晴夫

脊柱靭帯骨化症に関する調査研究令和2年度総括・分担研究報告書(Web)　2021年
TiNbSn合金で開発した人工股関節ステムの3年以上経過例の短期成績

千葉大介, 山田則一, 大山正瑞, 大津進, 桑原功行, 馬場一慈, 田中秀達, 花田修治, 井樋栄二, 相澤俊峰

日本股関節学会学術集会プログラム・抄録集　48th　2021年
馬尾に発生した悪性リンパ腫の1例

鈴木学, 相澤俊峰, 橋本功, 高橋康平, 半田恭一, 井樋栄二

東北整形災害外科学会プログラム・抄録集　118th　2021年
全身性疾患に伴う脊椎病変~腫瘍性疾患(脊椎転移など)と脊椎病変~

大野木孝嘉, 高橋康平, 橋本功, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　118th　2021年
思春期に診断されたposterior hemivertebraに対して短縮骨切り術を施行した1例

高橋康平, 半田恭一, 大野木孝嘉, 橋本功, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　118th　2021年
MRIによるEden分類2型と3型の脊髄砂時計腫の鑑別

木村礼, 橋本功, 高橋正樹, 半田恭一, 鈴木学, 高橋康平, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　118th　2021年
胸椎後縦靭帯骨化症に対する後方進入前方除圧術(大塚変法)の手術成績とCTによる除圧の検証

高橋康平, 相澤俊峰, 橋本功, 小野田祥人, 半田恭一, 大野木孝嘉, 菅野晴夫, 小澤浩司

Journal of Spine Research (Web)　12　(3)　2021年

ISSN： 2435-1563
成人脊柱変形に対するdynamic compression hookを併用した脊柱短縮骨切り術-変形矯正効果とロッド折損予防の検討-

菅野晴夫, 菅野晴夫, 相澤俊峰, 橋本功, 小澤浩司

Journal of Spine Research (Web)　12　(3)　2021年

ISSN： 2435-1563
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の成績-後方除圧固定術との比較-

相澤俊峰, 橋本功, 高橋康平, 大野木孝嘉, 半田恭一, 菅野晴夫, 小澤浩司

Journal of Spine Research (Web)　12　(3)　2021年

ISSN： 2435-1563
脊髄神経鞘腫摘出術における神経根切離後の神経脱落症状の検討

半田恭一, 相澤俊峰, 村上大史, 大野木孝嘉, 高橋康平, 橋本功, 小澤浩司, 井樋栄二

Journal of Spine Research (Web)　12　(3)　2021年

ISSN： 2435-1563
硬膜内髄外腫瘍における神経鞘腫と髄膜腫のMRI鑑別アルゴリズムの有効性

村上大史, 相澤俊峰, 半田恭一, 大野木孝嘉, 鈴木学, 高橋康平, 小野田祥人, 橋本功, 小澤浩司, 井樋栄二

Journal of Spine Research (Web)　12　(3)　2021年

ISSN： 2435-1563
胸椎OPLLに対する弯曲型ドリルとT-sawを用いた新たな後方進入前方除圧-安全・確実な除圧が術後の麻痺悪化を回避し早期離床を可能にする-

菅野晴夫, 菅野晴夫, 相澤俊峰, 橋本功, 高橋康平, 半田恭一, 井樋栄二, 小澤浩司

Journal of Spine Research (Web)　12　(3)　2021年

ISSN： 2435-1563
胸椎OPLLに対する弯曲型ドリルとT-sawを用いた安全・確実な後方進入前方除圧-術後の麻痺悪化の回避と早期離床の促進-

菅野晴夫, 相澤俊峰, 橋本功, 小澤浩司, 小澤浩司

日本脊椎インストゥルメンテーション学会抄録集　30th　2021年
腰椎変性すべり症に対する全内視鏡下トランスカンビン腰椎椎体間固定術(KLIF)の有用性と課題

山屋誠司, 橋本功, 古泉豊, 鈴木学, 須田英明, 八幡健一郎, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本内視鏡外科学会総会(Web)　34th　2021年
前額断MRIによる腰椎椎間孔部狭窄の診断-T1・T2強調画像の信頼性・再現性と読影傾向の比較検証-

橋本功, 田中靖久, 相澤俊峰, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 両角直樹, 古泉豊, 佐藤哲朗, 小澤浩司, 菅野晴夫, 国分正一, 井樋栄二

Journal of Spine Research (Web)　12　(3)　2021年

ISSN： 2435-1563
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の手術成績

相澤俊峰, 橋本功, 菅野晴夫, 半田恭一, 小野田祥人, 井樋栄二, 小澤浩司

Journal of Spine Research (Web)　11　(3)　2020年

ISSN： 2435-1563
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の新たな工夫-弯曲型ドリルとT-sawによる安全・確実な前方除圧-

菅野晴夫, 相澤俊峰, 橋本功, 衛藤俊光, 井樋栄二

Journal of Spine Research (Web)　11　(3)　2020年

ISSN： 2435-1563
片側椎間関節切除に固定術を併用しない胸椎砂時計腫摘出術の中長期成績:多施設研究

石川裕也, 大橋正幸, 平野徹, 渡辺慶, 松田倫治, 菅野晴夫, 橋本功, 半田恭一, 相澤俊峰, 赤羽武, 鈴木智人, 嶋村之秀

東北整形災害外科学会雑誌　63　(1)　2020年

ISSN： 1348-8694
自然縮小した胸椎部砂時計腫の1例

鈴木学, 相澤俊峰, 橋本功, 菅野晴夫, 小野田祥人, 井樋栄二

東日本整形災害外科学会雑誌(Web)　32　(2)　2020年

ISSN： 2433-569X
Surgical Approach to Pigmented Villonodular Synovitis and Synovial Osteochondromatosis in Pathological Expansion of the Popliteus Bursa. 国際誌

Takehiko Sugita, Nobuyuki Itaya, Toshimi Aizawa, Masayuki Kamimura, Atsushi Takahashi, Naohisa Miyatake

Arthroscopy techniques　8　(12)　e1495-e1499　2019年12月

DOI： 10.1016/j.eats.2019.07.028 　

詳細を見る詳細を閉じる

We orthopaedic surgeons are not familiar with the popliteus bursa. It is defined as the expansion in the synovial membrane of the posterolateral part of the knee that lies between the lateral meniscus and the tendon of the popliteus muscle. The popliteus bursa extends approximately 1 cm distal to the joint line and has 4 borders; the medial border is the peripheral margin of the lateral meniscus, the lateral border is the popliteus tendon, and the superior and inferior borders are formed by 2 fascicles. We very rarely observe cystic lesions that expand more distally, such as pigmented villonodular synovitis (PVNS) and synovial osteochondromatosis. We consider the distally expanded bursa as the pathologic expansion of the popliteus bursa. When this expansion is involved with PVNS, it may be the cause of recurrence of PVNS in the knee joint. Synovial osteochondromatosis in this expansion may cause pain in the posterolateral corner of the knee and may become a source of free bodies in the knee joint. In such conditions, these lesions should be surgically excised. The purpose of this Technical Note is to describe a surgical approach to the pathologic expansion of the popliteus bursa.
不安定型骨盤輪骨折に対するDual‐SAI screwsを用いた整復固定術―Extended tab screwによるreduction technique―

小野田祥人, 小野田祥人, 菅野晴夫, 相澤俊峰, 橋本功, 大柳琢, 大柳琢, 久志本成樹, 井樋栄二

東日本整形災害外科学会雑誌　31　(3)　435-435　2019年8月5日
出版者・発行元：東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
Destructive discovertebral degenerative diseaseの1例

松田倫治, 相澤俊峰, 橋本功, 菅野晴夫, 山屋誠司, 衛藤俊光, 半田恭一, 井樋栄二

東北整形災害外科学会雑誌　62　(1)　154-154　2019年6月
出版者・発行元：東北整形災害外科学会
ISSN： 1348-8694
除圧固定術後に麻痺が増悪した胸椎OPLLの検討

相澤俊峰, 衛藤俊光, 菅野晴夫, 小野田祥人, 橋本功, 半田恭一, 半田恭一, 小澤浩司

Journal of Spine Research　10　(3)　2019年

ISSN： 1884-7137
脊柱靭帯骨化症に関する調査研究胸椎OPLLに対する手術成績の検討-後方進入前方除圧術と後方除圧術の比較-

小澤浩司, 衛藤俊光, 相澤俊峰, 菅野晴夫, 橋本功

脊柱靭帯骨化症に関する調査研究平成30年度総括・分担研究報告書(Web)　2019年
Postoperative Changes in Presepsin Level and Values Predictive of Surgical Site Infection After Spinal Surgery: A Single-Center, Prospective Observational Study. 国際誌

Tomoaki Koakutsu, Tetsuya Sato, Toshimi Aizawa, Eiji Itoi, Shigeki Kushimoto

Spine　43　(8)　578-584　2018年4月15日

DOI： 10.1097/BRS.0000000000002376 　

ISSN： 0362-2436
胸椎後縦靱帯骨化症手術の多施設前向き研究術後運動麻痺リスク因子の解析

今釜史郎, 安藤圭, 竹内一裕, 加藤仁志, 相澤俊峰, 松山幸弘, 渡邉航太, 松本守雄, 吉井俊貴, 大川淳

日本整形外科学会雑誌　92　(2)　S124-S124　2018年3月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
プレセプシンの整形外科周術期における動態と基準値策定の試み単一施設前向き観察研究

小圷知明, 佐藤哲哉, 相澤俊峰, 井樋栄二, 久志本成樹

日本整形外科学会雑誌　92　(3)　S774-S774　2018年3月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
悪性腫瘍との鑑別が問題となった胸壁熱傷の1例

越智純子, 常陸真, 綿貫宗則, 保坂正美, 相澤俊峰, 渡辺みか

Japanese Journal of Radiology　36　(Supplement)　14　2018年2月25日

ISSN： 1867-1071
脊髄係留症候群に対し一期的に脊髄係留解除術と脊柱短縮骨切り術を行った1例

藤井駿, 菅野晴夫, 相澤俊峰, 橋本功, 井樋栄二, 小澤浩司

東北整形災害外科学会プログラム・抄録集　115th　2018年
胸腰椎部meningeal cystの手術治療

日下部隆, 中村豪, 関口玲, 衛藤俊光, 菅野晴夫, 橋本功, 相澤俊峰

東北整形災害外科学会雑誌　61　(1)　2018年

ISSN： 1348-8694
術後評価 9)頚髄症における術後脊髄腫脹の検討-MRI Gd-DTPA増強効果との関係

小澤浩司, 相澤俊峰, 舘田聡, 橋本功, 菅野晴夫, 佐藤哲朗

整形外科　69　(6)　2018年

ISSN： 0030-5901
Fluoroscopy-Guided Sacroiliac Intraarticular Injection via the Middle Portion of the Joint. 国際誌

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa

Pain medicine (Malden, Mass.)　18　(9)　1642-1648　2017年9月1日
出版者・発行元： Oxford University Press
DOI： 10.1093/pm/pnw297 　

ISSN： 1526-4637 1526-2375
成人脊柱変形の病態と治療後彎症患者はなぜ歩行中に体幹が傾くのか? 3次元動作解析による体幹-骨盤-下肢アライメントの検討

鎌田久美, 相澤俊峰, 井樋栄二, 小澤浩司, 関口雄介, 出江紳一

東北整形災害外科学会雑誌　60　(1)　176-176　2017年6月
出版者・発行元：東北整形災害外科学会
ISSN： 1348-8694
脊柱後弯症患者における歩行時の体幹前傾化の要因

鎌田久美, 小澤浩司, 関口雄介, 相澤俊峰, 出江紳一, 井樋栄二

日本整形外科学会雑誌　91　(2)　S158　2017年3月13日

ISSN： 0021-5325
胸椎後縦靱帯骨化症手術における術後運動麻痺関連因子多施設前向き研究

今釜史郎, 安藤圭, 竹内一裕, 加藤仁志, 相澤俊峰, 松山幸弘, 渡邉航太, 松本守雄, 吉井俊貴, 大川淳, 厚労科研, AMED班研究胸椎AM, 手術多施設研究グループ

日本整形外科学会雑誌　91　(3)　S738-S738　2017年3月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
脊柱靭帯骨化症に関する調査研究強直性脊椎病変の画像所見に関する研究

衛藤俊光, 相澤俊峰, 菅野晴夫, 橋本功, 小澤浩司

脊柱靭帯骨化症に関する調査研究平成28年度総括研究報告書(Web)　2017年
整形外科周術期におけるmitochondrial DNAの動態

小圷知明, 山田充啓, 工藤大介, 桑原功行, 橋本功, 相澤俊峰, 井樋栄二, 久志本成樹

日本整形外科学会雑誌　90　(8)　S1717　2016年8月31日

ISSN： 0021-5325
脊柱後彎症患者における歩行時の脊柱-骨盤-下肢関節アライメントの検討

鎌田久美, 小澤浩司, 関口雄介, 相澤俊峰, 出江紳一, 井樋栄二

日本整形外科学会雑誌　90　(8)　S1505-S1505　2016年8月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
Lumbar artery injury from which the Adamkiewicz artery originated associated with lumbar spine injury: successfully treated by transcatheter arterial embolization. 国際誌

Tomoaki Koakutsu, Toshimi Aizawa, Hironao Yuzawa, Eiji Itoi, Shigeki Kushimoto

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　25 Suppl 1　124-8　2016年5月

DOI： 10.1007/s00586-015-4225-2 　

ISSN： 0940-6719
脊椎手術後のプレセプシン値の推移―術後創傷感染症早期診断における有用性―

小圷知明, 佐藤哲哉, 桑原功行, 工藤大介, 相澤俊峰, 橋本功, 井樋栄二, 久志本成樹

日本整形外科学会雑誌　90　(2)　S86　2016年3月4日

ISSN： 0021-5325
Benign thoracic dumbbell tumor can be removed through hemilaminectomy and facetectomy without spinal reconstruction. 国際誌

Toshimi Aizawa, Hiroshi Ozawa, Ko Hashimoto, Haruo Kanno, Shoichi Kokubun, Eiji Itoi

Journal of neurosurgical sciences　60　(1)　145-8　2016年3月

ISSN： 0390-5616

eISSN： 1827-1855
腰部脊柱管狭窄症に対する内視鏡下椎弓切除術と棘突起縦割式椎弓切除術の前向き比較試験

山屋誠司, 中村聡, 千田香織, 菅野晴夫, 橋本功, 相澤俊峰, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　90　(3)　2016年

ISSN： 0021-5325
脊柱後彎症における歩行時姿勢の検討

鎌田久美, 小澤浩司, 関口雄介, 相澤俊峰, 出江紳一, 井樋栄二

日本整形外科学会雑誌　89　(8)　S1637-S1637　2015年9月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
T1神経根症とその特徴的症候

田中靖久, 椿野巧, 星川健, 高橋康平, 鈴木学, 松田倫治, 橋本功, 菅野晴夫, 相澤俊峰

Journal of Spine Research　6　(3)　2015年

ISSN： 1884-7137
中高齢者脊柱後弯症における歩行時姿勢の検討

鎌田久美, 小澤浩司, 関口雄介, 相澤俊峰, 出江紳一, 井樋栄二

運動器リハビリテーション = The journal of musculoskeletal medicine : 日本運動器科学会誌　26　(4)　414-418　2015年
出版者・発行元：日本運動器科学会
ISSN： 2187-8420
動脈塞栓術が奏効した仙骨骨巨細胞腫の2例

常陸真, 高橋昭喜, 綿貫宗則, 保坂正美, 相澤俊峰, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　88　(6)　S1280-S1280　2014年6月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
最近10年間の当科におけるLuque SSI法の経験

吉田新一郎, 小澤浩司, 相澤俊峰, 中村豪, 菅野晴夫, 小圷知明, 井樋栄二

東北整形災害外科学会雑誌　57　(1)　15-19　2014年6月
出版者・発行元：東北整形災害外科学会
ISSN： 1348-8694

詳細を見る詳細を閉じる

最近10年間に当科でLuque SSI法を行った12例について検討した。疾患の内訳は、転移性脊椎腫瘍が5例、頸胸椎脱臼骨折が3例、原発性脊椎腫瘍が2例、破裂骨折後の遅発性麻痺が2例であった。Luque SSI法を用いた理由は、椎弓根が細いためが5例、転移性脊椎腫瘍のためが4例、頸椎のためが3例であった。固定範囲はSegmental sublaminar wiringを頭尾側各3に椎弓を行った例が9例、頸椎で各2に椎弓を行った例が3例であった。11例で最終経過観察時まで良好な固定が維持された。術後合併症は、1例で術後一時的に麻痺の増悪を認めたが、術後1ヵ月以内に改善した。また、1例でワイヤーの折損による後彎変形を認め、再手術を要した。
自家骨移植により骨欠損部を再建し人工膝関節置換術を行ったCharcot関節の1例

佐々木毅志, 杉田健彦, 佐々木啓, 前田郁雄, 本間哲夫, 大沼正宏, 相沢俊峰, 柏葉光宏, 高橋敦, 藤澤博一, 上村雅之

東北整形災害外科学会雑誌　57　(1)　133-136　2014年6月
出版者・発行元：東北整形災害外科学会
ISSN： 1348-8694

詳細を見る詳細を閉じる

症例は57歳女性で、50歳時よりCharcot膝関節の経過観察中であったが、56歳より左膝関節の内反変形、特に脛骨内側顆部の骨欠損が急速に進行した。今回、関節破壊の進行を懸念して、脛骨内側顆部に大きな骨欠損を伴ったCharcot左膝関節に対し自家骨移植を用いた人工膝関節置換術(TKA)を行った。術後1年で移植骨内側部に骨梁が確認され、術後3年で移植骨は周囲と同化し、経過良好であった。
頚椎椎間板ヘルニアに対する脊柱管拡大術の長期成績-多施設前向き研究による前方除圧固定術との比較-

小圷知明, 佐々木盛力, 両角直樹, 石井祐信, 国分正一, 関口玲, 橋本功, 相澤俊峰, 井樋栄二, 笠間史夫, 田中靖久, 佐藤哲朗, 山崎伸

Journal of Spine Research　5　(3)　2014年

ISSN： 1884-7137
脊柱後弯症に対する短期集中型のリハビリテーション訓練の効果について-介入の前後を比較した予備的研究-

関口雄介, 関口雄介, 小澤浩司, 金子雅明, 相澤俊峰, 橋本功, 菅野晴夫, 出江紳一, 井樋栄二

運動器リハビリテーション　25　(2)　2014年

ISSN： 2187-8420
腰部脊柱管狭窄症における荷重MRIと脊髄造影の比較

菅野晴夫, 遠藤俊毅, 小澤浩司, 相澤俊峰, 古泉豊, 両角直樹, 石井祐信, 井樋栄二

Journal of Spine Research　3　(3)　215-215　2012年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN： 1884-7137
【炎症など悪性骨・軟部腫瘍と見まちがう疾患-診断のポイント】骨組織球症臨床・画像上の特徴と悪性腫瘍との鑑別

保坂正美, 羽鳥正仁, 常陸真, 綿貫宗則, 相沢俊峰, 井樋栄二

整形・災害外科　54　(10)　1159-1170　2011年9月
出版者・発行元：金原出版(株)
ISSN： 0387-4095
鎖骨骨幹部骨折に対する骨接合術における成績不良例の検討

峯田光能, 相澤利武, 笹島功一, 八田卓久

骨折　32　(1)　77-79　2010年2月25日

ISSN： 0287-2285
責任高位による胸部脊髄症の診断の問題点上位と下位罹患例の診断過程の比較

中村豪, 相澤俊峰, 小澤浩司, 日下部隆, 井樋栄二

Journal of Spine Research　1　(4)　1014-1014　2010年
宮城県住民における腰椎椎間板ヘルニア手術の疫学調査

日下部隆, 小澤浩司, 相澤俊峰, 小川真司, 松本不二夫, 村上栄一, 笠間史夫, 田中靖久, 石井祐信, 佐藤哲朗, 井樋栄二, 国分正一

Journal of Spine Research　1　(4)　827-827　2010年
骨粗鬆性椎体骨折偽関節に対する椎弓根スクリューとフックを併用した脊柱短縮術

小澤浩司, 田中靖久, 星川健, 相澤俊峰, 日下部隆, 中村豪, 井樋栄二, 国分正一

Journal of Spine Research　1　(3)　290-290　2010年
脂肪髄膜瘤による脊髄係留症候群に対する脊柱短縮骨切り術の手術成績

相澤俊峰, 小澤浩司, 日下部隆, 中村豪, 井樋栄二, 星川健, 田中靖久, 国分正一

日本整形外科学会雑誌　84　(4)　S671-S671　2010年
仙骨前面巨大神経鞘腫の治療

小澤浩司, 相澤俊峰, 日下部隆, 中村豪, 井樋栄二

日本整形外科学会雑誌　84　(4)　S420-S420　2010年
脊髄髄膜腫の臨床症状、手術成績について神経鞘腫との比較

中村豪, 小澤浩司, 相澤俊峰, 日下部隆, 井樋栄二

日本整形外科学会雑誌　84　(4)　S418-S418　2010年
特発性胸髄硬膜外脂肪腫の1例

篠崎晋久, 小津浩司, 相澤俊峰, 星川健, 川原央, 千葉大介, 井樋栄二

東北整形災害外科学会雑誌　53　(1)　188-189　2009年6月
出版者・発行元：東北整形災害外科学会
ISSN： 1348-8694
両下肢麻痺で発症したdumbbell型ユーイング肉腫ファミリー腫瘍(ESFT)の1例

森谷邦彦, 熊谷直憲, 松本幸子, 新妻秀剛, 小沼正栄, 力石健, 笹原洋二, 久間木悟, 土屋滋, 相沢俊峰, 保坂正美

日本小児科学会雑誌　113　(4)　751-751　2009年4月
出版者・発行元： (公社)日本小児科学会
ISSN： 0001-6543
脊髄神経鞘腫の臨床症状、手術成績について

小澤浩司, 相澤俊峰, 星川健, 日下部隆, 井樋栄二

日本脊椎脊髄病学会雑誌　20　(2)　577-577　2009年
胸椎連続型OPLLに対する後方除圧術の限界

小澤浩司, 武井寛, 伊藤拓緯, 相澤俊峰, 星川健, 日下部隆, 菅野晴夫, 石井祐信, 佐藤哲朗, 井樋栄二

日本脊椎脊髄病学会雑誌　20　(2)　370-370　2009年
【変性腰椎の治療戦略】変性腰椎(脊柱管狭窄症)の画像診断腰部脊柱管狭窄症の荷重MRI

菅野晴夫, 小澤浩司, 相澤俊峰, 星川健, 日下部隆, 井樋栄二, 石井祐信, 国分正一

関節外科　28　(5)　580-587　2009年
原発性骨盤腫瘍に対し動脈塞栓術とビスフォスフォネート製剤を用いた治療経験

保坂正美, 羽鳥正仁, 綿貫宗則, 星川健, 相澤俊峰, 日下部隆, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　83　(6)　S864-S864　2009年
腰部脊柱管狭窄症における荷重MRIの検討

菅野晴夫, 小澤浩司, 相澤俊峰, 星川健, 川原央, 井樋栄二

東北整形災害外科学会雑誌　53　(1)　237-237　2009年
銃弾による胸髄損傷の1例

星川健, 千葉大介, 菅野晴夫, 橋本功, 川原央, 相澤俊峰, 小澤浩司

東北整形災害外科学会雑誌　53　(1)　232-232　2009年
環軸関節回旋により脊髄圧迫が生じた脊髄砂時計腫 2例報告

日下部隆, 小澤浩司, 相澤俊峰, 星川健, 中村豪, 石井祐信, 井樋栄二

東日本整形災害外科学会雑誌　21　(3)　386-386　2009年
前仙骨シュワン腫の外科的治療 5症例報告

PongsthornChanplakorn, 小澤浩司, 相澤俊峰, 日下部隆, 中村豪, 井樋栄二

東日本整形災害外科学会雑誌　21　(3)　282-282　2009年
頭痛を契機に発見されたC1/C2椎間関節嚢腫の1例

中嶋信人, 野本達也, 水越元気, 上田雅之, 橋本功, 相澤俊峰, 小澤浩司, 永山寛, 山崎峰雄, 片山泰朗

日本頭痛学会誌　35　(2)　79-79　2008年11月
出版者・発行元： (一社)日本頭痛学会
ISSN： 1345-6547
両下肢麻痺で発症したdumbbell型ユーイング肉腫ファミリー腫瘍(ESFT)の1例

森谷邦彦, 熊谷直憲, 松本幸子, 新妻秀剛, 小沼正栄, 力石健, 笹原洋二, 久間木悟, 土谷滋, 相沢俊峰, 保坂正美

小児がん　45　(プログラム・総会号)　318-318　2008年11月
出版者・発行元： (NPO)日本小児がん学会
ISSN： 0389-4525
腰部脊柱管狭窄症における荷重MRI

菅野晴夫, 小澤浩司, 相澤俊峰, 星川健, 川原央, 井樋栄二

日本脊椎脊髄病学会雑誌 = The journal of the Japan Spine Research Society　19　(2)　415-415　2008年3月20日

ISSN： 1346-4876
頚髄症MRIにおける髄内増強病巣について

小澤浩司, 佐藤哲朗, 兵藤弘訓, 佐々木祐筆, 両角直樹, 小泉豊, 松谷重恒, 松本不二夫, 中村豪, 相澤俊峰, 星川健, 川原央, 笠間史夫, 田中靖久, 石井祐信, 国分正一

日本脊椎脊髄病学会雑誌 = The journal of the Japan Spine Research Society　19　(1)　26-26　2008年3月20日

ISSN： 1346-4876
脊椎内視鏡下手術の現状ー2006年1月〜12月手術施行状況調査・インシデント報告集計結果ー (日整会誌)

長谷川徹, 相澤俊峰, 猪川輪哉, 伊東学, 江原宗平, 岡治道, 加藤真介, 加藤圭彦, 川上守, 川原範夫, 古賀公明, 紺野慎一, 坂本直俊, 佐藤公治, 佐藤公昭, 高野裕一, 高橋誠, 田中雅人, 出沢明, 中野恵介, 中村博亮, 夏山元伸, 長谷川和宏, 蜂谷裕道, 平泉裕, 藤本吉範, 前川慎吾, 前田健, 松本守雄, 三上靖夫, 望月眞人, 八木省次, 山縣正庸, 山元拓哉, 湯澤洋平, 吉田宗人, 四宮謙一, 戸山芳昭

日整会誌　81　1072-1077　2007年12月
エストロゲンの欠如は成長軟骨板軟骨細胞を減少させる

高野広之, 相澤俊峰, 入江太一, 国分正一, 井樋栄二

日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association　81　(9)　732-732　2007年9月25日

ISSN： 0021-5325
仙腸関節性疼痛に対する関節内外ブロック療法の効果について

村上栄一, 田中靖久, 相澤俊峰, 石塚正人, 国分正一

日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association　81　(7)　601-601　2007年7月25日

ISSN： 0021-5325
黄色靱帯骨化. (脊椎脊髄ジャーナル)

相澤俊峰, 田中靖久, 星川健, 小澤浩司, 川原央, 井樋栄二

脊椎脊髄ジャーナル　20　117-124　2007年5月
脊椎類骨骨腫に伴う側彎の本態傍脊柱筋の筋融解

川原央, 小澤浩司, 田中靖久, 相沢俊峰, 星川健, 石井祐信, 佐藤哲朗, 国分正一

日本脊椎脊髄病学会雑誌　18　(1)　62-62　2007年3月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN： 1346-4876
脊椎骨切り術による胸椎・肋骨近位部軟骨肉腫の治療

小澤浩司, 川原央, 星川健, 相澤俊峰, 松本不二夫, 田中靖久, 国分正一

日本脊椎脊髄病学会雑誌 = The journal of the Japan Spine Research Society　17　(1)　243-243　2006年3月20日

ISSN： 1346-4876
特発性脊髄ヘルニアの神経症候. (脊椎脊髄ジャーナル)

相澤俊峰, 田中靖久, 国分正一

脊椎脊髄ジャーナル　18　535-539　2005年10月
頚椎前方除圧固定術（ASF）のクリティカルパス. (整形災害外科)

相澤俊峰, 富谷明人, 国分正一, 菅野知恵, 小綿瑞恵

整形災害外科　47　553-561　2004年10月
【内分泌病理学最近の進歩 2003】終糸発生傍神経節腫の1例 (ホルモンと臨床)

渡辺みか, 森谷卓也, 笹野公伸, 相澤俊峰

ホルモンと臨床　51　(臨増)　158-161　2003年8月
脊椎好酸球性肉芽腫の MRI 所見の経時的変化

相澤俊峰, 田中靖久, 小澤浩司, 松本不二夫, 星川健, 国分正一

日本脊椎脊髄病学会雑誌 = The journal of the Japan Spine Research Society　14　(1)　390-390　2003年2月20日

ISSN： 1346-4876
下垂指(drop finger)をきたす頚部神経根症

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

日本脊椎脊髄病学会雑誌 = The journal of the Japan Spine Research Society　14　(1)　345-345　2003年2月20日

ISSN： 1346-4876
運動負荷と骨格筋細胞のIL-6

富山明人, 相澤俊峰, 川又朋麿, 国分正一, 永富良一, 泉水宏臣

日本整形外科学会雑誌　76　(8)　S957-S957　2002年8月
出版者・発行元： (公社)日本整形外科学会
ISSN： 0021-5325
第1肋骨に発生し脊椎に浸潤した骨巨細胞腫の1手術例

樋口和東, 田中靖久, 星川健, 相沢俊峰, 両角直樹, 後藤均, 佐藤哲朗, 国分正一

東北整形災害外科紀要　46　(1)　132-132　2002年6月
出版者・発行元：東北整形災害外科学会
ISSN： 0040-8751
胸椎部特発性脊髄ヘルニア

相澤俊峰, 佐藤哲朗, 田中靖久, 松本不二夫, 両角直樹, 星川健, 国分正一

日本脊椎脊髄病学会雑誌 = The journal of the Japan Spine Research Society　13　(1)　53-53　2002年4月26日

ISSN： 1346-4876
第1肋骨に発生し脊椎に浸潤した骨巨細胞腫の1手術例

樋口和東, 田中靖久, 星川健, 相沢俊峰, 両角直樹, 佐藤哲朗, 国分正一

日本脊椎脊髄病学会雑誌　13　(1)　63-63　2002年4月
出版者・発行元： (一社)日本脊椎脊髄病学会
ISSN： 1346-4876
遠心性運動負荷と骨格筋細胞のIL-6 : その発現と経時的変化について

富谷明人, 相澤俊峰, 川又朋麿, 国分正一, 永富良一, 泉水宏臣, 上住聡芳

日本整形外科スポーツ医学会雑誌 = Japanese journal of orthopaedic sports medicine　22　(1)　86-86　2002年2月28日

ISSN： 1340-8577
【頸椎後彎症】先天性頸椎後彎症

国分正一, 田中靖久, 小澤浩司, 相澤俊峰, 佐藤哲朗, 石井祐信

脊椎脊髄ジャーナル　14　(1)　16-21　2001年
【脊椎外科最近の進歩】髄内腫瘍の診断と摘出術における課題

佐藤哲朗, 田中靖久, 小澤浩司, 相澤俊峰, 国分正一

臨床整形外科　36　(4)　379-385　2001年

DOI： 10.11477/mf.1408903245 　
【小児整形外科最近の動向】小児脊髄腫瘍と片側望椎弓切除による摘出術

国分正一, 佐藤哲朗, 田中靖久, 小澤浩司, 相澤俊峰

整形・災害外科　44　(9)　1101-1109　2001年
多数回手術を要した多発性脊柱靱帯骨化症の1例

中條悟, 佐藤哲朗, 田中靖久, 小澤浩司, 後藤均, 相沢俊峰, 石塚正人, 綿貫宗則, 国分正一

東北整形災害外科紀要　44　(2)　259-259　2000年12月
出版者・発行元：東北整形災害外科学会
ISSN： 0040-8751
骨折治癒過程の内軟骨骨化における軟骨細胞のアポトーシス

相澤俊峰, 川又明麿, 国分正一, 金民世, GERSTENFELD LC., EINHORN TA.

日本整形外科學會雜誌　74　(8)　S1724　2000年8月25日

ISSN： 0021-5325
脊髄髄内腫瘍の診断と摘出術における課題

佐藤哲朗, 田中靖久, 小澤浩司, 相澤俊峰, 中条悟, 国分正一

日本脊椎外科学会雑誌 = The journal of the Japan Spine Research Society　11　(1)　3-3　2000年4月28日

ISSN： 0915-6496
腰部変性後弯症に対する後方侵入楔状骨切り術術式の開発と成績

国分正一, 佐藤哲朗, 田中靖久, 相沢俊峰, 古泉豊

日本脊椎外科学会雑誌 = The journal of the Japan Spine Research Society　9　(1)　29-29　1998年5月22日

ISSN： 0915-6496
【黄色靱帯骨化症】胸椎部黄色靱帯骨化症の手術法と合併症

佐藤哲朗, 田中靖久, 相沢俊峰

脊椎脊髄ジャーナル　11　(5)　505-510　1998年5月
出版者・発行元： (株)三輪書店
ISSN： 0914-4412
成長軟骨板におけるアポトーシス関連蛋白の局在と役割

相澤俊峰, 国分正一, 田中靖久, ROACH H. I.

日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association　71　(8)　S1583　1997年8月25日

ISSN： 0021-5325
成長軟骨板における Fas 抗原と非コラーゲン蛋白の発現

相澤俊峰, 国分正一, 田中靖久

日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association　70　(8)　S1528　1996年8月25日

ISSN： 0021-5325
成長軟骨板におけるPCNAの発現とアポトーシス : 成長停止のメカニズムを考える

相澤俊峰, 国分正一, 樫本修, 高松克哉, 松村康弘, 田中靖久

日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association　69　(8)　S1554　1995年8月25日

ISSN： 0021-5325
第6頸椎分離症の1例

相沢俊峰, 神尾一彦, 鈴木寛

東北整形災害外科紀要　37　(1)　21-23　1993年5月
出版者・発行元：東北整形災害外科学会
ISSN： 0040-8751

︎全件表示 ︎最初の5件までを表示

書籍等出版物 4

スキル関節鏡下手術アトラス脊椎内視鏡下手術.

相澤俊峰

2013年4月1日
アトラス骨・関節画像診断. 5. 脊椎・脊髄

山下敏彦, 相澤俊峰, 小澤浩司

中外医学社　2011年7月
最新整形外科学大系第１巻運動器の生物学と生体力学

越智隆弘, 相澤俊峰, 杉田健彦

中山書店　2008年9月
Ossification of the Posterior Longitudinal Ligament

Tanaka Y, Sato, T, Aizawa T

Springer　2006年10月

講演・口頭発表等 16

最近の大学病院における化膿性脊椎炎の臨床症状、画像所見の特徴

日整会学術総会　2013年5月23日
腰部脊柱管狭窄症に対する開窓術後再手術例の検討

日本脊椎脊髄病学会　2013年4月25日
Thoracic myelopathy in Japan 国際会議

Annual meeting of Taiwan Spine Society　2013年3月21日
生存解析を用いた腰椎椎間板ヘルニア再発手術率の検討.

相澤俊峰ほか

日本脊椎脊髄病学会　2012年4月19日
腰椎椎間板ヘルニア再発手術例の疫学的検討

相澤俊峰ほか

日本整形外科学会総会　2011年5月15日
合併症による腰椎再手術：東北大学脊椎外科懇話会手術登録14046手術の検討.

相澤俊峰ほか

日本脊椎脊髄病学会　2011年4月20日
脂肪髄膜瘤による脊髄係留症候群に対する脊柱短縮骨切り術の手術成績

相澤俊峰, 小澤浩司, 日下部隆, 中村豪, 国分正一, 田中靖久, 井樋栄二

日本整形外科学会総会　2010年5月17日
10. Spine-shortening Vertebral Osteotomy for the Patients with Tethered Cord Syndrome Caused by Spinal Lipoma. 国際会議

Aizawa T, Kokubun S, Ozawa H, Kusakabe T, Itoi E

European Federation of National Associations of Orthopaedics and Traumatology,　2009年6月3日
成人では胸髄症に対する椎弓切除術後に局所後弯がどれくらい進行するか

相澤俊峰, 佐藤哲朗, 小澤浩司, 星川健, 松本不二夫, 国分正一

第81回日整会学術総会　2008年5月22日
胸部脊髄症134例の手術成績の検討

相澤俊峰, 佐藤哲朗, 佐々木祐肇, 松本不二夫, 両角直樹, 日下部隆, 川原央, 星川健, 小澤浩司, 田中靖久, 国分正一

日本脊椎脊髄病学会　2007年4月26日
Results of surgery for thoracic myelopathy 国際会議

Aizawa T, Sato T

American Academy of Orthopaedic Surgeons　2007年2月14日
脊柱靱帯骨化症による脊髄症手術症例の疫学的研究

相澤俊峰, 田中靖久, 小澤浩司ほか

日本整形外科学会総会　2006年4月20日
Analysis of 139 patients with thoracic myelopathy caused by ossification of the ligamentum flavum. 国際会議

Aizawa T, Sato T, Kokubun S, Kusakabe T, Morozumi K

American Academy of Orthopaedic Surgeons　2006年3月22日
5. Analysis of 139 patients with thoracic myelopathy caused by ossification of the ligamentum flavum. 国際会議

Aizawa T, Sato T

American Academy of Orthopaedic Surgeons　2006年3月22日
Ananysis of 139 patients with thoracic myelopathy caused by ossofocatoin of the ligamentum flavum 国際会議

Aizawa T, Sato T

American Academy of Orthopaedic Surgeons　2006年3月22日
Analysis of 139 patients with thoracic myelopathy caused by ossification of the ligamentum flavum 国際会議

Aizawa T, Sato T

American Academy of Orthopaedic Surgeons　2006年3月22日

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 3

胸椎後縦靭帯骨化症による脊髄圧迫障害を脊髄内応力マッピングで可視化・定量化する

高橋康平, 橋本功, 相澤俊峰, 大野木孝嘉

2023年4月1日～ 2026年3月31日

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先行研究として行っていた胸椎後縦靭帯骨化症に対する新しい術式である後方進入前方除圧術の手術成績の論文「Anterior shift of the ventral dura mater: A novel concept of the posterior surgery for ossification of the posterior longitudinal ligament in thoracic spine」が2023年4月にFrontiers in Surgeryに採択された。また、2023年に行われた日本脊椎脊髄病学会（札幌）、Eurospine(フランクフルト)で胸椎後縦靭帯骨化症に関する研究の報告を行った。これらの報告では、胸椎後縦靭帯の画像上の重症度と手術成績などの関連を報告している。有限要素法による応力解析を行うために十分な機能を有するパソコンを購入し、のソフトウェアをインストールした。解析するためのプログラミングを、東京都立大学工学部の坂元氏に依頼している。解析するための症例はすでに蓄積されており、画像上の計測（骨化後弯角、脊柱占拠率、OPLLの形態の解析）をおこなった。臨床症状と比較し、責任椎間を同定した。ソフトウェアが使用可能になった時点で、脊髄応力解析を開始し、画像上の計測値や臨床症状との関連を調べる計画となっている。9月頃から画像の解析に着手する予定としている。
成長軟骨板軟骨細胞に対する性ホルモンの影響

山田則一, 相澤俊峰, 大沼正宏, 川又朋麿, 山田則一

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2002年～ 2004年

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ネンブタール静脈麻酔下に、8週齢の雄の日本白色家兎から精巣を摘出した。10,15,20,25週で安楽死させた。すなわち精巣摘出-屠殺時期で,8-10,8-15,8-20,8-25週群の4グループを作った。またコントロールとして、10,15,20,25週齢の正常なウサギのグループを作った。屠殺時に採血し、テストステロン濃度が、精巣摘出群では、検出閾値(0.1ng/ml)以下であることを確認した。大腿骨頚部の成長軟骨板を観察するため、脱灰、パラフィン包埋後、2.5μmの薄切スライドを作成し、HE染色、PCNA、Caspase-3、Osteopontinなどの免疫染色を行った。精巣摘出群では、成長軟骨板の高さが減少し、増殖細胞層の柱状構造が正常家兎より早く乱れ、また増殖細胞層の軟骨細胞の形状が肥大化する傾向がみられた。また、免疫染色からは精巣摘出によって軟骨細胞の増殖能の低下、細胞死が増加する傾向がみられた。次いで、in vitroで軟骨細胞に対する性ホルモン負荷に対する影響を知るため、軟骨細胞の分離培養を行った.胎生17日の鶏の胸骨を摘出し、HE染色で頭側1/4が肥大細胞で、尾側1/2が非肥大細胞で構成されていることを確認した。胸骨の頭側5mm尾側8mmを採取し、Gerstenfeldらの方法に準じて培養した。培養した細胞からRNAを抽出し、reversetranscription-polymerase chain reaction(RT-PCR)法を行った。頭側の軟骨細胞ではX型コラーゲンを、尾側はII型コラーゲンを産生していた。すなわち、mRNAレベルで、前者が成熟した肥大細胞、後者が未熟な非肥大細胞であることが確認された。この培養系を用いて、性ホルモンの負荷実験を行った。テストステロン、エストロゲンを10-10,10-9,10-8,10-7,10-6mol/lの濃度勾配をつけ負荷した。APL活性、増殖能、細胞死、コラーゲンII、XなどのmRNA発現の変化を観察した。テストステロンでは、細胞増殖能の増加、エストロゲンでは、細胞死が増加する傾向がみられた
内軟骨骨化での軟骨細胞に対する腫瘍壊死因子(TNF)の働き

相澤俊峰, 大沼正宏, 川又朋麿, 川又朋磨

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2000年～ 2001年

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長管骨の伸長を司る成長軟骨板や、骨折治癒過程では内軟骨骨化がみられる。この骨化過程において軟骨細胞は増殖、成熟、肥大、そしてプログラム細胞死=アポトーシス細胞という連続した変化を示す。プログラム細胞死を惹起する因子はdeath factorと呼ばれ、腫瘍壊死因子(TNF)ファミリーに属するTNF-α、Fasリガンド、TRAILや酸化窒素(NO)などが知られる。本研究では骨折治癒過程におけるTNFの働きを、この軟骨細胞に対するアポトーシスの観点から捉えるとともに、他のdeath factorについても発現を観察した。 BALB/Cマウスの脛骨の横骨折モデルを用いた。術後1、2、3週でマウスを安楽死させ、RNase protection assay(RPA)で脛骨中のcaspase-8、TNF-αとその受容体であるp55、FasリガンドとFas受容体、TRAILのmRNAを同定した。また、これらの蛋白の発現を免疫染色により検討した。ボストン大字から提供されたTNF-α受容体のノックアウトマウス(TNF-α-KO)でも同様に骨折モデルを作製し、RPAで仮骨中のcaspase-8の発現を観察した。 BALB/Cマウスでは骨折後1週で骨折部付近では内軟骨骨化により作られた軟骨仮骨が骨折部を架橋していた。骨折後2週では軟骨細胞や軟骨性仮骨はまだ確認できたが、骨折後3週で骨折部はprimary spongiosaにより完全に癒合された。一方、TNF-α-KOでは、骨折後2週、3週で骨折仮骨が大量に残存し、骨折治癒過程が遅れる傾向にあった。 RPAでは、BALB/Cマウスでcaspase-8、TNF-αとp55、Fasリガンドと受容体、TRAILの発現が各群で認められた。これらの抗体を用いた免疫染色では、主に軟骨細胞で発現が認められた。またp55^-/p75^-マウスではcaspase-8のmRNAがほとんど同定できなかった。本研究から骨折治癒過程にある軟骨細胞では、少なくとも3種傾の異なったdeath factor、TNF-α、Fasリガンド、TRAILが発現していた。軟骨仮骨が新生骨に変わるためには、軟骨細胞が除去されなければならない。この過程において軟骨細胞はこれらのdeath factorを発現し、オートクリン/パラクリン機序で"自殺"する可能性が考えられる。TNF-α受容体ノックアウトマウスでcaspase-8がほとんど発現していなかったことから、中でもTNF-αがその中心的な役割を担っている可能性が示唆された。

その他 2

急性脊髄損傷に対する顆粒球コロニー刺激因子を用いた神経保護療法

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急性脊髄損傷に対する顆粒球コロニー刺激因子を用いた神経保護療法
大学病院における化膿性脊椎炎の最近の動向

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大学病院における化膿性脊椎炎の最近の動向