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Toshimi Aizawa

Section

Graduate School of Medicine

Job title

Professor

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/read0052212

J-GLOBAL ID

200901051229097360

Committee Memberships 10

日本整形外科学会　理事

2025/05 - Present
日本運動器学会　評議員

2022/07 - Present
日本腰痛学会　評議員

2021/10 - Present
東日本整形災害外科学会　理事

2021/05 - Present
東北整形災害外科学会　幹事

2021/04 - Present
日本整形外科学会　代議員

2017/05 - Present
東日本整形災害外科学会　評議員

2015/09 - Present
日本脊椎脊髄病学会　評議員

2011/04 - Present
東北整形災害外科学会　事務局長

2004/01 - 2011/12
日本脊椎脊髄病学会　理事

2024/04 -

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Professional Memberships 3

日本脊椎脊髄病学会(2010/04-2014/04 評議員)
日本整形外科学会(2008/07- 脊椎内視鏡下手術医療安全対策小委員会委員)
日本整形外科学会(2006/05-2008/05 脊椎内視鏡下手術インシデントワーキンググループメンバー)

Research Interests 4

spine surgery
ossification of the posterior longitudinal ligament of thoracic spine
chondrocyte
growth plate

Research Areas 1

Life sciences / Orthopedics / spine surgery

Papers 319

Limited effect of preoperative dental clearance on infection prevention in primary or revision hip arthroplasty for high- and low-risk groups

Kazuyoshi Baba, Hidetatsu Tanaka, Ryuichi Kanabuchi, Yasuaki Kuriyama, Daisuke Chiba, Yu Mori, Toshimi Aizawa

Journal of Orthopaedic Reports　2025/04

DOI： 10.1016/j.jorep.2025.100565 　
Preoperative Osteoporosis Treatment Reduces Stress Shielding in Total Hip Arthroplasty

Ryuichi Kanabuchi, Yu Mori, Kazuyoshi Baba, Hidetatsu Tanaka, Yasuaki Kuriyama, Hideki Fukuchi, Hiroki Kawamata, Toshimi Aizawa

Medical Sciences　2025/01/28

DOI： 10.3390/medsci13010010 　
Does Osteonecrosis of the Femoral Head Increase Early Complication Rates After Total Hip Arthroplasty? A Japanese Nationwide Medical Claims Database Study

Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Yasuaki Kuriyama, Hiroki Kawamata, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

The Journal of Arthroplasty　2025/01/23

DOI： 10.1016/j.arth.2025.01.029 　

ISSN： 0883-5403
Limited impact of weekend admissions on hip fracture outcomes in elderly patients: A study from a Japanese nationwide medical claims database.

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Geriatrics & gerontology international　2024/12/04

DOI： 10.1111/ggi.15041 　

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AIM: The effectiveness of early surgery in preventing complications in elderly Japanese hip fracture patients and the impact of weekend hospitalization need further investigation. The purpose of this study was to determine whether weekend hospitalization affects the incidence of various sequelae and death during hospitalization in elderly hip fracture patients using a comprehensive Japanese hip fracture case database. METHODS: We retrospectively analyzed the Japanese National Administrative DPC (Diagnosis Procedure Combination) database from April 2016 to March 2022. During this period, approximately 1100 DPC-affiliated hospitals consistently provided medical records with consent for the study. The study focused on weekend hospitalizations and investigated the associations with postoperative pneumonia, pulmonary embolism, myocardial infarction, urinary tract infection, acute renal dysfunction, dementia, and in-hospital mortality after propensity score matching. Owing to the large population size of the study, significance levels were strictly enforced, and a P-value < 0.001 was considered statistically significant. RESULTS: After performing propensity score matching based on age, sex, and comorbidities, 111 035 patient pairs were identified, comparing those admitted on weekends versus weekdays. The analysis showed no heightened risk of sequelae for those admitted during the weekend compared with weekdays. Additionally, there was a slight trend toward higher mortality risk during weekend hospital stays; however, the increase was insignificant, with a hazard ratio of 1.071 (95% confidence interval: 1.005-1.140, P = 0.03). CONCLUSION: The results of this study indicate that weekend hospitalization for elderly patients with hip fractures is not definitively associated with an increase in various sequelae or in-hospital mortality and that the importance of early surgery for elderly patients with hip fractures may be recognized and promoted in Japan. Geriatr Gerontol Int 2024; ••: ••-••.
Destructive spondyloarthropathy of the lumbar spine in patients on long-term haemodialysis: a computed tomography-based study. International-journal

Yutaka Yabe, Keisuke Ishikawa, Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　2024/11/26

DOI： 10.1007/s00586-024-08578-y 　

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PURPOSE: Destructive spondyloarthropathy (DSA) is a serious complication of long-term haemodialysis; it commonly occurs in the cervical spine and has been investigated in cervical lesions. Although DSA of the lumbar spine has been reported, only few studies have investigated this, and the characteristics of patients with lumbar DSA are unclear. The present study aimed to elucidate the prevalence of DSA and its clinical characteristics in patients with DSA in the lumbar spine using computed tomography (CT) images of the patients who underwent lumbar spine surgery. METHODS: Consecutive patients undergoing haemodialysis who underwent lumbar spine surgery (n = 67) were assessed. DSA was diagnosed using CT images, and the patients were divided into non-DSA and DSA groups. The differences in the clinical characteristics of the patients in the two groups were analysed. RESULTS: The prevalence of patients diagnosed with DSA was 31.3%. The mean intra- and inter-observer kappa values of DSA classification using CT images were 0.68 and 0.53, respectively. Although there were no significant differences in the age, sex, body mass index, reason for lumbar surgery, disease causing haemodialysis, age at the start of haemodialysis, or duration of haemodialysis between the non-DSA and DSA groups, the duration of haemodialysis tended to be longer in the DSA group. CONCLUSION: Among patients on haemodialysis who underwent lumbar spine surgery, the prevalence of patients with DSA was 31.3%. Classification of DSA using CT showed moderate-to-substantial agreement. Patients with DSA tended to have a longer haemodialysis duration.
Total Knee Arthroplasty in Patients With Ankle Osteoarthritis Affects Contralateral Ankle Alignment and Postoperative Outcome of Total Knee Arthroplasty. International-journal

Tomoki Koyama, Yu Mori, Shunsuke Utsumi, Kento Harada, Kentaro Ito, Hidetatsu Tanaka, Takashi Aki, Hideaki Nagamoto, Masayuki Kamimura, Toshimi Aizawa

Foot & ankle international　10711007241283783-10711007241283783　2024/11/06

DOI： 10.1177/10711007241283783 　

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BACKGROUND: This study investigated the impact of total knee arthroplasty (TKA) on the alignment of the ankle joint, focusing on changes in coronal alignment of both ankles. METHODS: This retrospective study, conducted at our hospital, included 64 patients older than 70 years who underwent TKA for varus knee osteoarthritis (OA). Using full-length standing radiographs of both lower extremities taken preoperatively and 6 months postoperatively, we assessed ankle OA grading based on the Takakura-Tanaka classification and measured mechanical hip-knee-ankle (mHKA) and the tibiotalar angle (TTA) on both the surgical and contralateral side. Additionally, we examined the impact of ankle OA on postoperative clinical scores, the Knee injury and Osteoarthritis Outcome Score, following TKA. RESULTS: Based on the classification, ankle OA stage 2 or higher was present in 13 cases on the surgical side and 13 cases on the contralateral side. On the surgical side, mHKA changed from 12.2 to 1.8 degrees varus (P < .001) and TTA from 1.7 to 1.0 degrees varus (P = .002). On the contralateral side, mHKA changed from 4.0 to 5.4 degrees varus (P = .04), and TTA from 2.7 to 3.0 degrees varus (P < .001). In ankle OA stage 2 or higher patients, contralateral TTA changed from 5.2 to 6.5 degrees varus (P < .001) and unchanged in stage 1 patients. Ankle OA stage 2 or higher patients had worse ADL outcomes than stage 1 patients (score: 67.2 and 78.3, respectively, P = .03). CONCLUSION: This study suggests an apparent interrelationship between knee and ankle OA and the potential negative influence of TKA on ankle OA.
TiNbSn Alloy Plates with Low Young's Modulus Modulates Interfragmentary Movement and Promote Osteosynthesis in Rat Femur

Tomoki Koyama, Yu Mori, Masayuki Kamimura, Hidetatsu Tanaka, Rui Tome, Ketaro Ito, Masashi Koguchi, Naoko Mori, Toshimi Aizawa

Journal of the Mechanical Behavior of Biomedical Materials　106820-106820　2024/11
Publisher: Elsevier BV
DOI： 10.1016/j.jmbbm.2024.106820 　

ISSN： 1751-6161
Impact of Aging and Knee Osteoarthritis on Lower Limb Alignment and CPAK Classification: Gender Differences in a Japanese Cohort

Kento Harada, Yu Mori, Masayuki Kamimura, Takashi Aki, Tomoki Koyama, Toshimi Aizawa

Journal of Clinical Medicine　2024/10/19

DOI： 10.3390/jcm13206250 　
Rheumatoid arthritis increases complication risks in elderly hip fracture patients.: A Japanese nationwide medical claims database study. International-journal

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Ryuichi Kanabuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Modern rheumatology　2024/09/05

DOI： 10.1093/mr/roae088 　

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OBJECTIVES: Rheumatoid arthritis (RA) is a common autoimmune disorder characterized by chronic inflammation and periarticular bone loss, leading to systemic osteoporosis and heightened fracture susceptibility, especially hip fractures among the elderly. This study aimed to evaluate the outcomes and complications associated with hip fractures in patients with RA relative to those without RA. METHODS: Using the Japanese National Administrative Diagnosis Procedure Combination (DPC) database, we examined cases of femoral neck fractures from April 2016 to March 2023. After one to three propensity score matching for age, sex, and complications, we examined the association between RA, complications, and mortality during hospitalization in elderly patients with hip fractures. RESULTS: The findings revealed that elderly Japanese RA patients with hip fractures had significantly higher complications of pneumonia than elderly hip fracture patients without RA, with a ratio of 1.232 (95% CI: 1.065-1.426, p=0.0056), and pulmonary embolism, with a ratio of 1.155 (95% CI: 1.036-1.287, p=0.009) in multivariate logistic regression analyses. Although not significantly elevated, it also found a trend toward higher mortality during hospitalization, with a ratio of 1.179 (95% CI: 0.973-1.429, p=0.096). CONCLUSIONS: A substantial study based on the Japanese DPC database revealed a significant association between RA and increased complications, including pneumonia and pulmonary embolism. On the other hand, there was a nonsignificant but higher trend for risk of mortality during hospitalization for hip fracture in elderly RA patients. Implementing preventive strategies is essential to minimizing complications in the treatment of hip fractures in patients with RA.
低弾性率チタン(TiNbSn)合金製ロッキングプレートはラット大腿骨骨切り部の骨癒合を促進する

古山和樹, 森優, 上村雅之, 田中秀達, 伊東健太郎, 古口昌志, 原田健登, 内海峻輔, 畠山拡, 正橋直哉, 相澤俊峰

日本整形外科学会雑誌　98　(8)　S1803-S1803　2024/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325

eISSN： 2758-7479
Preserving medial iliofemoral ligament avoids excessive leg lengthening in total hip arthroplasty using anterolateral-supine approach

Kurishima Hiroaki, Yamada Norikazu, Noro Atsushi, Tanaka Hidetatsu, Takahashi Shusuke, Tsuchida Kyota, Mori Yu, Aizawa Toshimi

Journal of Orthopaedics　2024/09

DOI： 10.1016/j.jor.2024.09.004 　
Surgery on admission and following day reduces hip fracture complications: a Japanese DPC study.

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Kenji Fujimori, Toshimi Aizawa

Journal of bone and mineral metabolism　2024/07/11

DOI： 10.1007/s00774-024-01534-2 　

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INTRODUCTION: The efficacy of early surgery in preventing complications among Japanese elderly patients with hip fractures requires further investigation. This study aims to use a comprehensive Japanese hip fracture case database to determine whether surgery within the day of admission and the following day reduces the incidence of complications and mortality during hospitalization in elderly hip fracture patients. MATERIALS AND METHODS: We retrospectively analyzed the Japanese National Administrative DPC (Diagnosis Procedure Combination) database from April 2016 to March 2022. Approximately 1100 DPC-affiliated hospitals consistently provided medical records with consent for research. The study investigated the association between postoperative pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization after propensity score matching, focusing on surgeries conducted on the day of admission and the following day. RESULTS: After one-to-one propensity score matching for age, gender, and comorbidity, we identified 146,441 pairs of patients who underwent surgery either within the day of admission and the following day or after the third day of admission. Surgery on the third day or later was independently associated with increased risks of pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization with risk ratios of 1.367 (95% CI 1.307-1.426), 1.328 (95% CI 1.169-1.508), 1.338 (95% CI 1.289-1.388), and 1.167 (95% CI 1.103-1.234), respectively. CONCLUSION: A comprehensive study of elderly Japanese patients with hip fractures in the DPC database showed that surgery on admission and the following day is crucial for preventing complications like pneumonia, deep vein thrombosis, pulmonary embolism, and mortality during hospitalization.
Acetabular coverage exerts minimal influence on femoral head collapse and the necessity for surgical intervention in patients with osteonecrosis of femoral head

Yasuaki Kuriyama, Hidetatsu Tanaka, Kazuyoshi Baba, Ryuichi Kanabuchi, Yu Mori, Toshimi Aizawa

International Orthopaedics　2024/06/20
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00264-024-06238-w 　

ISSN： 0341-2695

eISSN： 1432-5195

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Abstract Purpose The acetabular coverage in osteonecrosis of the femoral head (ONFH) affects the need for surgical intervention, and the collapse of the femoral head remains unclear. This study aimed to evaluate the relation between the acetabular coverage and the need for surgical treatment and femoral head collapse. Methods The study included 158 patients with 252 hips with glucocorticoid administration and idiopathic ONHF without osteoarthritis changes. The mean age at the first visit was 45.2 years, and the mean follow-up period was 92.2 months. All ONFH hips were subsequently divided into two groups: those needing surgical intervention and those without surgery. Additionally, it divided 167 initially non-collapsed hips into those that either later collapsed or not. Radiographic parameters with the centre-edge angle, acetabular roof obliquity, sharp angle, and necrotic location, following the guidelines of the Japanese Investigation Committee, were evaluated. Results There were no significant differences in radiographic parameters between the 106 hips that underwent surgery and the 146 hips without surgery. Among the 167 hips without initial collapse, 91 eventually collapsed while 76 did not; their radiographic findings have no significant differences. The necrotic locations were significantly larger in hips requiring surgical intervention or femoral head collapse. Furthermore, 21.8% (55 out of 252 hips) had acetabular dysplasia, which did not significantly correlate with the necessity for surgical treatment or the incidence of femoral head collapse. Conclusions Acetabular coverage has little effect on the necessity for surgical treatment and femoral head collapse in ONFH patients over a long-term follow-up.
Location and Size of the Reverse Hill-Sachs Lesion in Patients with Traumatic Posterior Shoulder Instability. International-journal

Kaijia Yang, Nobuyuki Yamamoto, Norimasa Takahashi, Hideki Kamijo, Kenji Okamura, Teruhisa Mihata, Hiroyuki Sugaya, Tadanao Funakoshi, Arino Atsushi, Jun Kawakami, Toshimi Aizawa, Eiji Itoi

Journal of shoulder and elbow surgery　2024/04/18

DOI： 10.1016/j.jse.2024.03.017 　

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BACKGROUND: In patients with traumatic posterior shoulder instability, little is known about the precise location and size of the reverse Hill-Sachs lesion. METHODS: Forty-nine shoulders of 47 patients with traumatic posterior instability were included in this study based on the following inclusion criteria: 1) a primary or recurrent traumatic posterior shoulder dislocation, and 2) the initial event was caused by trauma. Patients were excluded if they had: 1) no history of trauma, 2) prior shoulder surgery, 3) no CT examination, or 4) seizure cases. Three-dimensional images of the humerus reconstructed from CT images were reviewed using an image analysis software. The location and size of the reverse Hill-Sachs lesion were measured and described on a clock face on the humeral head. RESULTS: The reverse Hill-Sachs lesion was observed in 25 of 49 shoulders (51%). The reverse Hill-Sachs lesions were located between 1:37 and 2:48. The depth of the reverse Hill-Sachs lesion (mean ± SD) was 5.8 ± 2.2 mm. The extent of the reverse Hill-Sachs lesion was 35° ± 12°. The average orientation of the reverse Hill-Sachs lesion, represented by an angle measured from the 12 o'clock position, was 64° ± 12° and pointing towards 2:09 on a clock face. Length and width of reverse Hill-Sachs lesions were 9.7 ± 4.7 mm, 11.1 ± 3.6 mm, respectively. CONCLUSION: The reverse Hill-Sachs lesion was a semicircular compression fracture located on the anteromedial aspect of the humeral head. Compared with shoulders with anterior shoulder instability, the humeral defect was smaller and located more inferiorly in shoulders with posterior instability.
A Review of the Impacts of Implant Stiffness on Fracture Healing

Yu Mori, Masayuki Kamimura, Kentaro Ito, Masashi Koguchi, Hidetatsu Tanaka, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Toshimi Aizawa

Applied Sciences　2024/03/07

DOI： 10.3390/app14062259 　
Anterolateral supine approach THAにおける内閉鎖筋共同腱の解離が臨床転帰および股関節周囲筋筋力に与える影響は限定的である

田中秀達, 山田則一, 栗島宏明, 馬場一慈, 森優, 相澤俊峰

日本整形外科学会雑誌　98　(2)　S403-S403　2024/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325

eISSN： 2758-7479
Clinical Outcomes of Bipolar Hemiarthroplasty with a Conjoined Tendon-Preserving Posterior Approach for Femoral Neck Fractures

Tanaka, H., Mori, Y., Noro, A., Yano, T., Aizawa, T., Masuda, K.

Medicina (Lithuania)　60　(3)　2024/02/21

DOI： 10.3390/medicina60030356 　

ISSN： 1648-9144 1010-660X
Efficacy of Octacalcium Phosphate/Gelatin (OCP/Gel) Composite Implantation for Miniature Swine Lumbar Interbody Fusion

Yu Mori, Ryo Hamai, Ryuichi Kanabuchi, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa, Osamu Suzuki

The Tohoku Journal of Experimental Medicine　2024
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2024.j138 　

ISSN： 0040-8727

eISSN： 1349-3329
どこへいく?どうなる?脊椎内視鏡の教育脊椎内視鏡下手術がゴールドスタンダードになるために新時代の教育・普及活動

山屋誠司, 橋本功, 古泉豊, 矢部裕, 須田英明, 千葉美詩央, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本内視鏡外科学会雑誌　28　(7)　1054-1054　2023/12
Publisher: (一社)日本内視鏡外科学会
ISSN： 1344-6703

eISSN： 2186-6643
Reliability of Conventional Two-Dimensional Magnetic Resonance Imaging for Diagnosing Extraforaminal Stenosis in Lumbosacral Transition.

Kohei Takahashi, Myo Min Latt, Takumi Tsubakino, Manabu Suzuki, Takeshi Nakamura, Takeshi Hoshikawa, Tomowaki Nakagawa, Ko Hashimoto, Takahiro Onoki, Toshimi Aizawa, Yasuhisa Tanaka

Spine surgery and related research　7　(6)　526-532　2023/11/27

DOI： 10.22603/ssrr.2023-0110 　

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INTRODUCTION: Three-dimensional (3D) magnetic resonance imaging (MRI) is reportedly superior to two-dimensional (2D) MRI for diagnosing lumbar foraminal stenosis at L5-S1. In this study, we strictly distinguished the intra- and extraforaminal regions and compared the diagnostic reliability and accuracy of 2D and 3D MRI in each region. METHODS: A total of 92 surgical cases of unilateral L5 radiculopathy were selected for imaging analysis, including 46 of foraminal stenosis at L5-S1 (Group F) and 46 of intraspinal canal stenosis at L4-5 (Group C) (48 men, 44 women; mean age, 66 years). The 2D and 3D MRI sets were assessed twice by two examiners. They were informed only of the laterality of the lesion in each case and asked to select among the following for each modality: "absence of foraminal stenosis," "intraforaminal stenosis," "extraforaminal stenosis," and "coincident intraforaminal and extraforaminal stenosis." The intra- and interobserver reliabilities were evaluated using kappa (κ) statistics for the intra- and extraforaminal regions and compared between 2D and 3D MRI. For each case, disagreements between examiners were resolved through discussion to obtain a diagnostic judgment for each modality. Subsequently, the final diagnosis of intra- and/or extraforaminal stenosis in Group F was made using multiple modalities and intraoperative findings. A comparison between 2D and 3D MRI in terms of diagnostic accuracy was performed for the intra- and extraforaminal regions. RESULTS: No significant difference was observed in the κ statistics between 2D and 3D MRI for the intraforaminal region, whereas 3D MRI had significantly larger κ statistic than 2D MRI for the extraforaminal region. Ultimately, 3D MRI perfectly judged the extraforaminal region, whereas 2D MRI detected only 44.8% of the cases of extraforaminal stenosis. CONCLUSIONS: More than half of extraforaminal stenosis was overlooked by 2D MRI, suggesting that it is unreliable for diagnosing extraforaminal stenosis at L5-S1.
Are T1-Weighted Three-Dimensional Magnetic Resonance Images Inferior to T2-Weighted Images for Diagnosing Lumbar Foraminal Stenosis in the Fifth Lumbar Nerve Root? A Prospective, Comparative Study in Identical Patients.

Ko Hashimoto, Yasuhisa Tanaka, Takumi Tsubakino, Takeshi Hoshikawa, Chikashi Kawahara, Tomowaki Nakagawa, Satoshi Tateda, Kohei Takahashi, Manabu Suzuki, Takahiro Onoki, Haruo Kanno, Naoki Morozumi, Yutaka Koizumi, Masahito Honda, Takashi Kusakabe, Masaru Suda, Shoichi Kokubun, Toshimi Aizawa

Spine surgery and related research　7　(5)　436-442　2023/09/27

DOI： 10.22603/ssrr.2023-0026 　

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INTRODUCTION: Imaging analysis of foraminal stenosis in the fifth lumbar (L5) nerve root remains to be a challenge because of the anatomical complexity of the lumbosacral transition. T2-weighted three-dimensional (3D) magnetic resonance images (MRI) have been dominantly used for diagnosis of lumbar foraminal stenosis, while the reliability of T1-weighted images (WI) has also been proven. In this study, we aim to compare the reliability and reproducibility of T1- and T2-weighted 3D MRI in diagnosing lumbar foraminal stenosis (LFS) of the L5 nerve root. METHODS: In this study, 39 patients with unilateral L5 radiculopathy (20 had L4-L5 intracanal stenosis; 19 had L5-S foraminal stenosis) were enrolled, prospectively. T1- and T2-weighted 3D lumbar MRI were obtained from each patient. T1WI and T2WI were blinded and then separately reviewed twice by four examiners randomly. The examiners were instructed to answer the side of LFS or absence of LFS. The correct answer rate, sensitivity, specificity, and area under the curve were analyzed and compared between T1WI and T2WI. Also, intra- and interobserver agreements were calculated using kappa (κ)-statistics and compared in the same manner. RESULTS: The average correct answer rate, sensitivity, specificity, and area under the curve of the T1WI/T2WI were 84.6%/80.1%, 82.9%/80.3%, 86.3%/81.3%, and 0.846/0.801, respectively. The intraobserver κ-values of the four examiners ranged from 0.692 to 0.916 (average: 0.762) and from 0.669 to 0.801 (average: 0.720) for T1WI and T2WI, respectively. The interobserver κ-values calculated in a round-robin manner (24 combinations in total) ranged from 0.544 to 0.790 (average: 0.657) and from 0.524 to 0.828 (average: 0.652), respectively. CONCLUSIONS: As per our findings, T1- and T2-weighted 3D MRI were determined to have nearly equivalent reliability and reproducibility in terms of diagnosing LFS of the L5 nerve root.
Radical decompression without fusion for L5 radiculopathy due to foraminal stenosis. International-journal

Kohei Takahashi, Ajay Yadav, Takumi Tsubakino, Takeshi Hoshikawa, Tomowaki Nakagawa, Ko Hashimoto, Manabu Suzuki, Toshimi Aizawa, Yasuhisa Tanaka

Journal of spine surgery (Hong Kong)　9　(3)　278-287　2023/09/22

DOI： 10.21037/jss-23-62 　

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BACKGROUND: The highest incidence of lumbar foraminal stenosis (LFS) occurs in the L5-S1 segment and its anatomical features differ from those of other segments. Few previous reports have exhaustively assessed surgical outcomes after decompression surgery, limiting the materials to patients with LFS at the L5-S1 segment. We aimed to prospectively investigate instability and neurological improvement following our novel surgical technique for LFS at L5-S1, named "radical decompression" of the nerve root. METHODS: Patients with foraminal stenosis at L5-S1 who underwent surgery using our technique were prospectively evaluated two years postoperatively. The Japanese Orthopaedic Association (JOA) score and the JOA Back Pain Evaluation Questionnaire (JOABPEQ) were evaluated preoperatively and two years postoperatively. The following radiological parameters at L5-S1 were measured: lateral translation, sagittal translation, the difference in sagittal translation (DST) between flexion and extension, disc wedging angle, lordotic angle, the difference in lordotic angle (DLA) between flexion and extension, and disc height. Pre- and postoperative data were compared using paired t-tests. In addition, the patients were classified into a disc group (Group D) and a non-disc group (Group ND) according to whether a discectomy was performed intraoperatively. Changes in each parameter before and after surgery were compared between the groups. RESULTS: Twenty-eight patients were included in this analysis. The JOA scores improved in all patients. The mean preoperative and two-year postoperative JOA scores were 14.5±3.2 (range, 8-21) and 24.3±3.3 (range, 18-29), respectively (P<0.01). All JOABPEQ categories improved two years postoperatively (P<0.05). None of the patients underwent revision surgery. No significant changes were observed in any of the radiological parameters. No significant differences in the changes in each parameter before and after surgery were found between groups D and ND. CONCLUSIONS: Our surgical technique resulted in good neurological recovery and was associated with a low risk of postoperative segmental instability, regardless of additional discectomy.
鏡視下上方関節包再建術後の外旋改善は三角筋後部線維による

有野敦司, 山本宣幸, 佐々木一真, 木村礼, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　50回・20回　189-189　2023/09
Publisher: (一社)日本肩関節学会
鏡視下上方関節包再建術後の外旋改善は三角筋後部線維による

有野敦司, 山本宣幸, 佐々木一真, 木村礼, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　50回・20回　189-189　2023/09
Publisher: (一社)日本肩関節学会
MR画像を用いた軌跡外損傷評価の改善

木村礼, 山本宣幸, 有野敦司, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　50回・20回　293-293　2023/09
Publisher: (一社)日本肩関節学会
Primary Malignant Lymphoma of the Cauda Equina Diagnosed after Decompression for Lumbar Spinal Stenosis: A Case Report.

Manabu Suzuki, Kohei Takahashi, Mika Watanabe, Ko Hashimoto, Takahiro Onoki, Kyoichi Handa, Toshimi Aizawa

The Tohoku journal of experimental medicine　260　(4)　341-346　2023/08/23

DOI： 10.1620/tjem.2023.J047 　

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Primary malignant lymphoma confinement to the cauda equina is rare. Only 14 cases of primary malignant lymphoma in the cauda equina have been reported. In these cases, the clinical features were similar to those of lumbar spinal canal stenosis (LSCS). This report describes a case of diffuse large B-cell lymphoma of the cauda equina that was diagnosed after decompression surgery for LSCS. An 80-year-old man presented with gait disturbance due to progressive muscle weakness in the lower extremities over the previous two months. He was diagnosed with LSCS, and decompression surgery was performed. However, the muscle weakness worsened after surgery; therefore, he was referred to our department. Plain magnetic resonance imaging (MRI) revealed swelling of the cauda equina. It demonstrated marked homogenous enhancement by gadolinium-diethylenetriamine pentaacetic acid. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) revealed diffuse accumulation of 18F-FDG in the cauda equina. These imaging findings were consistent with those of cauda equina lymphomas. To confirm the diagnosis, we performed an open biopsy of the cauda equina. Histological examination indicated diffuse large B-cell lymphoma. Considering the patient's age and activities of daily living, further treatment was not performed. The patient died four months after the first surgery. Rapid progression of muscle weakness, which cannot be prevented by decompression surgery, and swollen cauda equina on MRI may be signs of this disorder. Gadolinium-enhanced MRI, 18F-FDG PET, and histological investigation of the cauda equina should be performed for diagnosing primary malignant lymphoma of the cauda equina.
人工股関節全置換術前の口腔ケアは全例で必要か? 口腔ケアが必要な感染高リスク症例の抽出法の検討

馬塲一慈, 千葉大介, 森優, 金淵龍一, 栗山恭明, 栗島宏明, 鈴木貴之, 濱田壮志, 相澤俊峰

Hip Joint　49　(1)　57-59　2023/08
Publisher: 日本股関節学会
ISSN： 0389-3634
腱板断裂患者における脂肪化と筋萎縮平均6年の前向き調査

有野敦司, 山本宣幸, 川上純, 木村礼, 藍澤一穂, 永元英明, 佐野博高, 相澤俊峰, 井樋栄二

東日本整形災害外科学会雑誌　35　(3)　335-335　2023/08
Publisher: 東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
脊椎後彎症患者の変形矯正術前後で股関節の運動学的特性はどう変化するか? 三次元動作解析装置を用いた歩行解析による検討

藤田涼, 高橋康平, 関口雄介, 鎌田久美, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　97　(8)　S1841-S1841　2023/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
TiNbSn stems with gradient changes of Young’s modulus and stiffness reduce stress shielding compared to the standard fit-and-fill stems

Kazuyoshi Baba, Yu Mori, Daisuke Chiba, Yoshiyuki Kuwahara, Hiroaki Kurishima, Hidetatsu Tanaka, Atsushi Kogure, Masayuki Kamimura, Norikazu Yamada, Susumu Ohtsu, Masamizu Oyama, Naoya Masahashi, Shuji Hanada, Eiji Itoi, Toshimi Aizawa

European Journal of Medical Research　28　(1)　2023/07/03
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s40001-023-01199-z 　

eISSN： 2047-783X

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Abstract Background The difference between Young’s moduli of the femur and the stem causes stress shielding (SS). TiNbSn (TNS) stem has a low Young’s modulus and strength with gradient functional properties during the change in elastic modulus with heat treatment. The aim of this study was to investigate the inhibitory effect of TNS stems on SS and their clinical outcomes compared to conventional stems. Methods This study was a clinical trial. Primary THA was performed using a TNS stem from April 2016 to September 2017 for patients in the TNS group. Unilateral THA was performed using a Ti6Al4V alloy stem from January 2007 to February 2011 for patients in the control group. The TNS and Ti6Al4V stems were matched in shape. Radiographs were obtained at the 1- and 3-year follow-ups. Two surgeons independently checked the SS grade and appearance of cortical hypertrophy (CH). The Japanese Orthopaedic Association (JOA) scores before and 1 year after surgery were assessed as clinical scores. Results None of the patients in the TNS group had grade 3 or 4 SS. In contrast, in the control group, 24% and 40% of patients had grade 3 and 4 SS at the 1- and 3-year follow-ups, respectively. The SS grade was lower in the TNS group than in the control group at the 1- and 3-year follow-ups (p < 0.001). The frequencies of CH in both groups were no significant difference at the 1- and 3-year follow-ups. The JOA scores of the TNS group significantly improved at 1 year after surgery and were comparable to control group. Conclusion The TNS stem reduced SS at 1 and 3 years after THA compared to the proximal-engaging cementless stem, although the shapes of the stems matched. The TNS stem could reduce SS, stem loosening, and periprosthetic fractures. Trial registration: Current Controlled Trials. ISRCTN21241251. https://www.isrctn.com/search?q=21241251. The date of registration was October 26, 2021. Retrospectively registered.
THREE-COLUMN OSTEOTOMY WITH COMBINATION OF COMPRESSION HOOK AND PEDICLE SCREW FIXATION FOR ADULT SPINAL DEFORMITY IN PATIENTS WITH PARKINSON’S DISEASE

Haruo Kanno, Ko Hashimoto, Kohei Takahashi, Kyoichi Handa, Toshimi Aizawa, Hiroshi Ozawa

Journal of Musculoskeletal Research　26　(02)　2023/06/30
Publisher: World Scientific Pub Co Pte Ltd
DOI： 10.1142/s0218957723400055 　

ISSN： 0218-9577

eISSN： 1793-6497

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Purpose: Surgical treatment for adult spinal deformity (ASD) in patients with Parkinson’s disease (PD) is challenging and is associated with a significant risk of postoperative mechanical complications, such as rod breakage, pseudoarthrosis and proximal junctional failure. We herein report the surgical results of three-column osteotomy with pedicle screw fixation combined with compression hook for ASD associated with PD. Methods: We retrospectively investigated four patients with ASD due to PD who underwent three-column osteotomy with posterior instrumentation. The compression hook system placed on the laminae was used for closure of the osteotomy site during surgery and reinforcement of pedicle screw fixation. Surgical outcomes and radiographical parameters were analyzed. Results: Lumbar lordosis was improved from [Formula: see text] preoperatively to [Formula: see text] postoperatively, and [Formula: see text] at the final follow-up examination. The sagittal vertical axis was restored from 297 ± 104 mm preoperatively to 41 ± 13 mm postoperatively, and 72 ± 23 mm at the final follow-up examination. The preoperative VAS (88 ± 14 mm) for low back pain was significantly improved at the final follow-up examination (14 ± 28 mm). Walking disturbance due to low back pain was improved in all patients. No patients had mechanical failure (e.g. rod fracture, pseudarthrosis, or junctional failure) after surgery. Conclusion: The use of compression hooks to supplement pedicle screw fixation is beneficial for performing safe osteotomy closure during surgery and preventing postoperative mechanical failures, and may be a useful option when performing three-column osteotomy for ASD associated with PD.
PJI 人工関節周囲感染診断におけるalpha-defensin検査の有用性について

森優, 千葉大介, 上村雅之, 金淵龍一, 馬場一慈, 相澤俊峰

日本骨・関節感染症学会プログラム・抄録集　46回　108-108　2023/06
Publisher: (一社)日本骨・関節感染症学会
関節鏡視下に切除を行った上腕骨頭発生類骨骨腫の一例

有野敦司, 吉田新一郎, 岩津潤, 綿貫宗則, 山本宣幸, 相澤俊峰, 常陸真, 渡邉みか

東北整形災害外科学会雑誌　66　(1)　166-167　2023/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Long-term results of Chiari pelvic osteotomy on the preservation of hip function with mean follow-up of more than 30 years and its prognostic factors

Hiroaki Kurishima, Daisuke Chiba, Kazuyoshi Baba, Soshi Hamada, Takayuki Suzuki, Ryuichi Kanabuchi, Genji Fujii, Masamizu Oyama, Tatsuhiro Ochiai, Yu Mori, Toshimi Aizawa

Journal of Orthopaedic Science　2023/06
Publisher: Elsevier BV
DOI： 10.1016/j.jos.2023.05.013 　

ISSN： 0949-2658
【人工関節における進歩】バイオマテリアル金属素材と表面加工チタン合金・低弾性チタン合金低弾性チタン合金,チタン-ニオブ-スズ合金で開発した人工股関節ステムの成績と今後の展望

千葉大介, 山田則一, 森優, 馬場一慈, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

別冊整形外科　(83)　9-12　2023/04
Publisher: (株)南江堂
ISSN： 0287-1645

eISSN： 2433-4316
【人工関節における進歩】バイオマテリアル金属素材と表面加工チタン合金・低弾性チタン合金低弾性チタン合金,チタン-ニオブ-スズ合金で開発した人工股関節ステムの成績と今後の展望

千葉大介, 山田則一, 森優, 馬場一慈, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

別冊整形外科　(83)　9-12　2023/04
Publisher: (株)南江堂
ISSN： 0287-1645

eISSN： 2433-4316
Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway

Yu Mori, Kazuko Ueno, Daisuke Chiba, Ko Hashimoto, Yosuke Kawai, Kazuyoshi Baba, Hidetatsu Tanaka, Takashi Aki, Masanori Ogasawara, Naoto Shibasaki, Katsushi Tokunaga, Toshimi Aizawa, Masao Nagasaki

International Journal of Molecular Sciences　24　(5)　5019-5019　2023/03/06
Publisher: MDPI AG
DOI： 10.3390/ijms24055019 　

eISSN： 1422-0067

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This study examined the association between developmental dysplasia of the hip (DDH) and disease-associated loci in a Japanese cohort. A genome-wide association study (GWAS) of 238 Japanese patients with DDH and 2044 healthy individuals was performed. As a replicate, GWAS was also conducted on the UK Biobank data with 3315 cases and matched 74,038 controls. Gene set enrichment analyses (GSEAs) of both the genetics and transcriptome of DDH were performed. Transcriptome analysis of cartilage specimens from DDH-associated osteoarthritis and femoral neck fractures was performed as a control. Most of the lead variants were very low-frequency ones in the UK, and variants in the Japanese GWAS could not be replicated with the UK GWAS. We assigned DDH-related candidate variants to 42 and 81 genes from the Japanese and UK GWASs, respectively, using functional mapping and annotation. GSEA of gene ontology, disease ontology, and canonical pathways identified the most enriched pathway to be the ferroptosis signaling pathway, both in the Japanese gene set as well as the Japanese and UK merged set. Transcriptome GSEA also identified significant downregulation of genes in the ferroptosis signaling pathway. Thus, the ferroptosis signaling pathway may be associated with the pathogenic mechanism of DDH.
日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 千葉大介, 橋本功, 馬場一慈, 田中秀達, 植野和子, 長崎正朗, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S115-S115　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 綿貫宗則, 吉田新一郎, 森菜緒子, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S888-S888　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
新規に開発した同一stem内で剛性が変化するstem(TiNbSn stem)のstress shielding予防効果

馬場一慈, 千葉大介, 森優, 田中秀達, 小暮敦史, 桑原功行, 山田則一, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S1114-S1114　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
腱板断裂患者における脂肪化と筋萎縮平均6年の前向き調査

有野敦司, 山本宣幸, 木村礼, 藍澤一穂, 川上純, 永元英明, 佐野博高, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　97　(2)　S147-S147　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
肩関節外科に必要な解剖学関節唇および関節包靱帯の解剖および機能

山本宣幸, 有野敦司, 藍澤一穂, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　97　(2)　S515-S515　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
症候性腱板断裂患者の関節軟骨の変化平均6年の前向き研究

川上純, 山本宣幸, 有野敦司, 木村礼, 藍澤一穂, 佐野博高, 永元英明, 常陸真, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　97　(3)　S816-S816　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
関節窩骨欠損とHill-Sachs損傷の大きさの関係

高橋忠久, 山本宣幸, 有野敦司, 藍澤一穂, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　97　(3)　S1051-S1051　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
TiNbSn合金で開発した人工股関節ステムの5年以上経過例の中期成績

千葉大介, 山田則一, 大山正瑞, 大津進, 桑原功行, 馬場一慈, 田中秀達, 花田修治, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S219-S219　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
若年スポーツ選手における腰痛の頻度競技種目ごとの検討

矢部裕, 萩原嘉廣, 大野木孝嘉, 石川圭佑, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S73-S73　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
網羅的なタンパク解析による黄色靱帯肥厚の病態解明

矢部裕, 萩原嘉廣, 大野木孝嘉, 石川圭佑, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S318-S318　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊椎後彎症患者の立位静止時および歩行時の体幹前傾と股関節肢位の関係 3D動作解析装置とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S794-S794　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
日本人股関節形成不全患者の発症機序におけるフェロトーシスシグナルの関連

森優, 千葉大介, 橋本功, 馬場一慈, 田中秀達, 植野和子, 長崎正朗, 相澤俊峰

日本整形外科学会雑誌　97　(2)　S115-S115　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
SAPHO症候群の放射線学的特徴と臨床的多様性の検討

森優, 泉山拓也, 綿貫宗則, 吉田新一郎, 森菜緒子, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S888-S888　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
新規に開発した同一stem内で剛性が変化するstem(TiNbSn stem)のstress shielding予防効果

馬場一慈, 千葉大介, 森優, 田中秀達, 小暮敦史, 桑原功行, 山田則一, 大津進, 大山正瑞, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S1114-S1114　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Two-stage revision knee arthroplasty for metallosis in a patient with rheumatoid arthritis: A case report

Tomoki Koyama, Yu Mori, Masayuki Kamimura, Takashi Aki, Takuya Izumiyama, Naoko Mori, Daisuke Chiba, Ko Hashimoto, Nobuyuki Yamamoto, Toshimi Aizawa

SAGE Open Medical Case Reports　2023/01

DOI： 10.1177/2050313X231177752 　
Anterior shift of the ventral dura mater: A novel concept of the posterior surgery for ossification of the posterior longitudinal ligament in thoracic spine. International-journal

Kohei Takahashi, Ko Hashimoto, Takahiro Onoki, Haruo Kanno, Hiroshi Ozawa, Toshimi Aizawa

Frontiers in surgery　10　1120069-1120069　2023

DOI： 10.3389/fsurg.2023.1120069 　

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BACKGROUND: Thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) remains one of the most difficult disorders to treat. The Ohtsuka procedure, extirpation, or anterior floating of the OPLL through a posterior approach, has shown great surgical outcomes after several modifications. However, these procedures are technically demanding and pose a significant risk of neurological deterioration. We have developed a novel modified Ohtsuka procedure in which removal or minimization of the OPLL mass is unnecessary; instead, the ventral dura mater is shifted anteriorly with the posterior part of the vertebral bodies and targeted OPLL. SURGICAL PROCEDURE: First, pedicle screws were inserted at more than three spinal levels above and below the spinal level where pediculectomies were performed. After laminectomies and total pediculectomies, partial osteotomy of the posterior vertebra adjacent to the targeted OPLL was performed by using a curved air drill. Then, the PLL is completely resected at the cranial and caudal sites of the OPLL using special rongeurs or a threadwire saw with a diameter of 0.36 mm. The nerve roots were not resected during surgery. METHODS: Eighteen patients (follow-up ≥1 year) treated with our modified Ohtsuka procedure were assessed clinically, including the Japanese Orthopaedic Association (JOA) score for thoracic myelopathy and radiographically. RESULTS: The average follow-up period was 3.2 years (range, 1.3-6.1 years). The preoperative JOA score was 2.7 ± 1.7, which improved to 8.2 ± 1.8 at 1 year postoperatively; therefore, the recovery rate was 65.8 ± 19.8%. The CT scan at 1 year after surgery revealed the anterior shift of the OPLL averaged 3.1 ± 1.7 mm and the ossification-kyphosis angle of the anterior decompression site decreased at an average of 7.2 ± 6.8 degrees. Three patients demonstrated temporary neurological deterioration, all of whom completely recovered within 4 weeks postoperatively. DISCUSSION: The concept of our modified Ohtsuka procedure is 1) not OPLL extirpation or minimization but only the creation of space between the OPLL and spinal cord by an anterior shift of the ventral dura mater, which is achieved by complete resection of the PLL at the cranial and caudal sites of the OPLL; and 2) no nerve roots are sacrificed to prevent ischemic spinal cord injury. This procedure is not technically demanding and safe and provides secure decompression for thoracic OPLL. The anterior shift of the OPLL was smaller than expected, but it resulted in a relatively good surgical outcome with a recovery rate ≥65%. CONCLUSION: Our modified Ohtsuka procedure is quite secure and is not technically demanding, with a recovery rate of 65.8%.
A modified minimally invasive surgery for thoracic pyogenic spondylitis: Percutaneous pedicle screw fixation in combination with a vertebral debridement in a separate posterolateral approach—A case report

Yuki Sato, Ko Hashimoto, Michiharu Matsuda, Takahiro Onoki, Masayuki Kamimura, Kohei Takahashi, Yoshito Onoda, Daisuke Chiba, Yu Mori, Haruo Kanno, Nobuyuki Yamamoto, Toshimi Aizawa

Clinical Case Reports　10　(12)　2022/12
Publisher: Wiley
DOI： 10.1002/ccr3.6710 　

ISSN： 2050-0904

eISSN： 2050-0904
Impacts of external rotators and the ischiofemoral ligament on preventing excessive internal hip rotation: a cadaveric study

Kazuyoshi Baba, Daisuke Chiba, Yu Mori, Yoshiyuki Kuwahara, Atsushi Kogure, Takehiro Sugaya, Kumi Kamata, Itsuki Oizumi, Takayuki Suzuki, Hiroaki Kurishima, Soshi Hamada, Eiji Itoi, Toshimi Aizawa

Journal of Orthopaedic Surgery and Research　17　(1)　2022/12
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1186/s13018-021-02873-w 　

ISSN： 1749-799X

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<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>This study examined the biomechanics of preventing excessive internal hip joint rotation related to the hip flexion angle.</jats:p> </jats:sec><jats:sec> <jats:title>Method</jats:title> <jats:p>An intramedullary nail with a circular plate equipped with a protractor was installed in the femur of nine normal hips. The circular plate was pulled by 3.15 Nm of force in the internal rotation direction. The external rotators were individually resected, finally cutting the ischiofemoral ligament. The cutting order of the external rotators differed on each side to individually determine the internal rotation resistance. The external rotators were resected from the piriformis to the obturator externus in the right hips and the reverse order in the left hips. Traction was performed after excising each muscle and ischiofemoral ligament. Measurements were taken at 0°, 30°, and 60° of hip flexion, and the differences from baseline were calculated.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>For the right hip measurements, the piriformis and ischiofemoral ligament resection significantly differed at 0° of flexion (p = 0.02), each external rotator and the ischiofemoral ligament resections significantly differed at 30° of flexion (p < 0.01), and the ischiofemoral ligament and piriformis and inferior gemellus resections significantly differed at 60° of flexion (p = 0.04 and p = 0.02, respectively). In the left hips, the ischiofemoral ligament and obturator externus, inferior gemellus, and obturator internus resections significantly differed at 0° of flexion (p < 0.01, p < 0.01, and p = 0.01, respectively), as did each external rotator and the ischiofemoral ligament resections at 30° of flexion (p < 0.01).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The ischiofemoral ligament primarily restricted the internal rotation of the hip joint. The piriformis and obturator internus may restrict internal rotation at 0° and 60° of flexion.</jats:p> </jats:sec>
How much force is acting on the shoulder joint to create a Hill-Sachs Lesion or reverse Hill-Sachs Lesion?

Toshimitsu Etoh, Nobuyuki Yamamoto, Jun Kawakami, Masayuki Kamimura, Daisuke Chiba, Yu Mori, Ko Hashimoto, Toshimi Aizawa, Eiji Itoi

Journal of Orthopaedic Science　2022/10
Publisher: Elsevier BV
DOI： 10.1016/j.jos.2022.09.016 　

ISSN： 0949-2658
関節窩骨欠損とHill-Sachs損傷の大きさの関係

高橋忠久, 山本宣幸, 有野敦司, 藍澤一穂, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　135-135　2022/09
Publisher: (一社)日本肩関節学会
Latarjet法術後の移植骨の形態変化骨欠損の大小による比較

山本宣幸, 有野敦司, 藍澤一穂, 高橋忠久, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　140-140　2022/09
Publisher: (一社)日本肩関節学会
症候性腱板断裂患者の関節軟骨の変化平均6年の前向き研究

川上純, 山本宣幸, 有野敦司, 木村礼, 藍澤一穂, 永元英明, 佐野博高, 常陸真, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　149-149　2022/09
Publisher: (一社)日本肩関節学会
腱板断裂患者における脂肪化と筋萎縮平均6年の前向き調査

有野敦司, 山本宣幸, 川上純, 木村礼, 藍澤一穂, 永元英明, 佐野博高, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　150-150　2022/09
Publisher: (一社)日本肩関節学会
早期腱板断裂性関節症の調査 MRIによる軟骨の厚さの評価

木村礼, 山本宣幸, 有野敦司, 藍澤一穂, 川上純, 永元英明, 相澤俊峰, 井樋栄二

日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集　49回・19回　163-163　2022/09
Publisher: (一社)日本肩関節学会
β-type TiNbSn Alloy Plates with Low Young Modulus Accelerates Osteosynthesis in Rabbit Tibiae

Kentaro Ito, Yu Mori, Masayuki Kamimura, Masashi Koguchi, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Shuji Hanada, Eiji Itoi, Toshimi Aizawa

Clinical Orthopaedics and Related Research　480　(9)　1817-1832　2022/09/01

DOI： 10.1097/CORR.0000000000002240 　

ISSN： 0009-921X

eISSN： 1528-1132
Extracorporeal shockwave therapy in an immobilized knee model in rats prevents progression of joint contracture. International-journal

Jun Iwatsu, Yutaka Yabe, Kenji Kanazawa, Nobuyuki Itaya, Yasuhito Sogi, Yoshihumi Saijo, Toshimi Aizawa, Yoshihiro Hagiwara

Journal of orthopaedic research : official publication of the Orthopaedic Research Society　41　(5)　951-961　2022/08/28

DOI： 10.1002/jor.25433 　

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Joint immobilization, which ensures rest and accelerates tissue recovery in musculoskeletal disorders, often causes joint contracture, for which there is still no effective prevention. To address this, we investigated the effects of extracorporeal shockwave therapy (ESWT) in preventing joint contracture, in a unilaterally immobilized knee rat model. Under general anesthesia, ESWT (0.25 mJ/mm2 , 3000 shot, 4 Hz, 3 d/week) was administered from one day after immobilization up to 2, 4, and 6 weeks. The immobilized control group received general anesthesia without ESWT. We evaluated joint angle, tissue elasticity, and gene and protein expression related to fibrosis, inflammation, and angiogenesis in the joint capsule. Relative to the control, the ESWT group had greater joint angle at 4 and 6 weeks, and lower posterior-capsule elasticity at 6 weeks. In the ESWT group, at 6 weeks, gene expression of collagen type I (col1α1), connective tissue growth factor (CTGF), and α-smooth muscle actin (α-SMA) was significantly downregulated, whereas interleukin-6 (IL-6) and hypoxia inducible factor-1α (HIF-1α) gene expression was upregulated, relative to that in the control. Compared with that in the control, at 4 and 6 weeks, the ratio of CTGF+ cells were significantly lower in the ESWT group; at 4 weeks, the ESWT group had significantly fewer CD68+ cells in the adhesion area, and at 6 weeks, significantly more blood vessels. This article is protected by copyright. All rights reserved.
Destructive Spondyloarthropathy due to Congenital Insensitivity to Pain with Anhidrosis: A Case Report of Long-Term Follow-Up.

Ko Hashimoto, Kohei Takahashi, Takahiro Onoki, Haruo Kanno, Naoki Morozumi, Shin Yamazaki, Ken-Ichiro Yahata, Toshimi Aizawa

The Tohoku journal of experimental medicine　258　(2)　91-95　2022/08/26

DOI： 10.1620/tjem.2022.J060 　

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Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal-recessive hereditary neuropathy causing congenital loss of pain sensation, thermoception, and perspiration. CIPA sometimes causes destructive spondyloarthropathy, the so-called Charcot spine, because of insensitivity to pain stimuli. Herein, we report a case of CIPA with severe spinal destruction treated by multiple spinal reconstructive surgeries and over 15 years of follow-up. A 15-year-old male patient who had been diagnosed with CIPA at the age of 17 months presented to his previous spine clinic with gait disturbance due to muscle weakness in his lower extremities. Imaging studies revealed that collapsed L3 and L4 vertebral bodies involved the spinal canal, and it was treated by L3-L4 instrumented posterior fusion. Fourteen years after surgery, the patient became unable to walk again due to spinal canal stenosis at the proximal fusion segment. An L2-L3 posterior interbody fusion alleviated his gait ability for 2 years; however, he became unable to stand again because of the collapsed fusion segment that caused severe lumbar kyphosis. Subsequently, a two-staged posterior and anterior fusion surgery from the lower thoracic spine to the pelvis was performed, and spinal fusion and neurological recovery were achieved 3 years after surgery. A kyphotic deformity in patients with CIPA-associated Charcot spine could be favorably treated by a long spinal fusion in combination with a reconstruction of an anterior spinal column. This case report provides a significant lesson for a treatment of CIPA-associated Charcot spine.
首下がり・腰曲がり治療の最前線-現状と今後の展望- 成人脊柱後彎症の病態における骨盤傾斜の重要性

小澤浩司, 鎌田久美, 関口雄介, 菅野晴夫, 高橋康平, 相澤俊峰

東日本整形災害外科学会雑誌　34　(3)　190-190　2022/08
Publisher: 東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
外反型変形性膝関節症に対する遠位大腿骨骨切り術3例4膝の治療成績

有野敦司, 秋貴史, 上村雅之, 伊東健太郎, 阿部高久, 古口昌志, 佐藤宏陽, 藤盛理子, 相澤俊峰

東北膝関節研究会会誌　30　27-31　2022/07
Publisher: 東北膝関節研究会
ISSN： 0917-5164

eISSN： 2433-5614
Foraminal Stenosis at L5-S1 as an Overlooked Pathology of Bilateral Radiculopathy: A Case Series. International-journal

Kohei Takahashi, Ajay Kumar Yadav, Ko Hashimoto, Takumi Tsubakino, Toshimi Aizawa, Yasuhisa Tanaka

Journal of orthopaedic case reports　12　(6)　13-18　2022/06

DOI： 10.13107/jocr.2022.v12.i06.2846 　

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INTRODUCTION: The classical symptom of foraminal stenosis is unilateral radiculopathy. Bilateral radiculopathy caused purely by foraminal stenosis is rare. Here, we report five cases of bilateral L5 radiculopathy caused purely by L5-S1 foraminal stenosis and describe the clinical and radiological features of these patients in detail. CASE PRESENTATION: Among the five patients, two were men and three were women with an average age of 69 years. Four patients had undergone surgeries at L4-5 level, previously. All the patients showed an improvement in symptoms in the post-operative period. After a certain period, the patients complained of bilateral leg pain and numbness. An additional surgery was performed in two patients; however, there was no improvement in symptoms. One patient, who did not undergo surgery, was treated conservatively for 3 years. All the patients had been suffering from bilateral leg symptoms before their first visit to our hospital. The neurological findings in these patients were consistent with bilateral L5 radiculopathy. The average pre-operative Japanese Orthopedic Association (JOA) score was 13 out of 29 points. Bilateral foraminal stenosis at L5-S1 level was confirmed using a three-dimensional magnetic resonance imaging or computed tomography. Posterior lumbar interbody fusion was performed in one patient and bilateral lateral fenestration using Wiltse's approach was performed in four patients. The neurological symptoms recovered immediately after surgery. The average JOA score at 2-year follow-up was 25 points. CONCLUSIONS: Spine surgeons may overlook the pathology of foraminal stenosis, particularly in patients with bilateral radiculopathy. Familiarity with the clinical and radiological features of symptomatic lumbar foraminal stenosis is necessary to properly diagnose bilateral foraminal stenosis at L5-S1 level.
「若年に見られる膝外傷後変形性膝関節症のマネジメント」 ACL再建術後に生じるOA変化の実態 KOACADを用いた定量評価

秋貴史, 上村雅之, 伊東健太郎, 阿部高久, 古口昌志, 佐藤宏陽, 藤盛理子, 井樋栄二, 相澤俊峰, 曽木靖仁

東北整形災害外科学会雑誌　65　(1)　173-174　2022/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
硬膜内髄外腫瘍における神経鞘腫と髄膜腫のMRI鑑別アルゴリズムの有効性

村上大史, 半田恭一, 大野木孝嘉, 鈴木学, 高橋康平, 小野田祥人, 矢部裕, 橋本功, 小澤浩司, 相澤俊峰

東北整形災害外科学会雑誌　65　(1)　258-258　2022/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Post-laminectomy cervical flexion myelopathy and its possible pathomechanism: A case report.

Kohei Takahashi, Shinji Ogawa, Shuji Isefuku, Ko Hashimoto, Toshimi Aizawa

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2022/05/24

DOI： 10.1016/j.jos.2022.05.002 　
Innovation of Surgical Techniques for Screw Fixation in Patients with Osteoporotic Spine. International-journal

Haruo Kanno, Yoshito Onoda, Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa

Journal of clinical medicine　11　(9)　2022/05/04

DOI： 10.3390/jcm11092577 　

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Osteoporosis is a common disease in elderly populations and is a major public health problem worldwide. It is not uncommon for spine surgeons to perform spinal instrumented fusion surgeries for osteoporotic patients. However, in patients with severe osteoporosis, instrumented fusion may result in screw loosening, implant failure or nonunion because of a poor bone quality and decreased pedicle screw stability as well as increased graft subsidence risk. In addition, revision surgeries to correct failed instrumentation are becoming increasingly common in patients with osteoporosis. Therefore, techniques to enhance the fixation of pedicle screws are required in spinal surgeries for osteoporotic patients. To date, various instrumentation methods, such as a supplemental hook, sublaminar taping and sacral alar iliac screws, and modified screwing techniques have been available for reinforcing pedicle screw fixation. In addition, several materials, including polymethylmethacrylate and hydroxyapatite stick/granules, for insertion into prepared screw holes, can be used to enhance screw fixation. Many biomechanical tests support the effectiveness of these augmentation methods. We herein review the current therapeutic strategies for screw fixation and augmentation methods in the surgical treatment of patients with an osteoporotic spine.
The psoas major muscle is essential for bipedal walking - An analysis using a novel upright bipedal-walking android model. International-journal

Kouji Sanaka, Ko Hashimoto, Daisuke Kurosawa, Eiichi Murakami, Hiroshi Ozawa, Kohei Takahashi, Takahiro Onoki, Toshimi Aizawa

Gait & posture　94　15-18　2022/05

DOI： 10.1016/j.gaitpost.2022.02.018 　

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BACKGROUND: Bipedalism is a unique function in humans. Various investigations in bipedal walking have assessed the kinetic chain from the pelvis to the lower limbs. However, few studies have investigated the functions of the upper body including the psoas major muscles. In the present study, a bipedal-walking human full-body skeletal model, "the bipedal android model", was generated by attaching air cylinder devices to simulate the contraction and relaxation of various muscles required for bipedal walking, including the psoas major muscles. The bipedal-walking principle was discussed using the model. METHODS: Every part of a human full-body skeletal model was connected by wires or cables to retain the mobility of each joint. Then the psoas major (PM), gluteus minimus (GM), long head of biceps femoris (BF), quadriceps femoris (QF), and semimembranosus (SM) muscles were simulated in the skeletal model using air cylinders. The gait pattern was observed by synchronizing the contraction of PM, GM, QF and SM, and relaxation of BF of the ipsilateral side together with the reversed patterns in the contralateral side, and then switching the phase by every step. The gait pattern in dysfunction of PM or GM muscles was also observed by disconnecting the corresponding air cylinders. RESULTS: The synchronized contraction of PM, GM, QF and SM generates the force to tilt the upper body to ipsilateral side, followed by elevation of the lower limb together with the forward rotation of the pelvis in the contralateral side to swing the leg forward. The next step was generated by reversing the contraction phase at the landing of the swung leg. The dysfunction of PM muscle disabled effective gait in the model, while GM did not. SIGNIFICANCE: The bipedal android model indicated that the psoas major muscles play a crucial role in bipedal walking in human.
Reinforcement of Percutaneous Pedicle Screw Fixation with Hydroxyapatite Granules in Patients with Osteoporotic Spine: Biomechanical Performance and Clinical Outcomes. International-journal

Haruo Kanno, Yoshito Onoda, Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa

Medicina (Kaunas, Lithuania)　58　(5)　2022/04/23

DOI： 10.3390/medicina58050579 　

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In percutaneous pedicle screw (PPS) fixation of the osteoporotic spine, rigid screw fixation obtaining strong stabilization is important for achieving successful treatment outcomes. However, in patients with severe osteoporosis, it is difficult to obtain PPS fixation with sufficient stability. PPS fixation has potential disadvantages with respect to maintaining secure stabilization in comparison to conventional pedicle screw fixation. In PPS fixation, bone grafting to achieve posterior spine fusion is generally not applicable and transverse connectors between the rods cannot be used to reinforce the fixation. Various augmentation methods, including additional hooks, sublaminar bands, and hydroxyapatite (HA) sticks, are available for conventional pedicle screw fixation. On the other hand, there has been no established augmentation method for PPS fixation. Recently, we developed a novel augmentation technique for PPS fixation using HA granules. This technique allows the percutaneous insertion of HA granules into the screw hole along the guidewire prior to insertion of the PPS. We have used this augmentation technique for PPS fixation in various spine surgeries in patients with osteoporosis. In our previous studies, biomechanical analyses demonstrated that PPS fixation was significantly enhanced by augmentation with HA granules in the osteoporotic lumbar spine. Furthermore, augmentation with HA granules was considered to decrease the incidence of screw loosening and implant failure following PPS fixation in patients with osteoporotic spine. In this article, we describe the surgical procedures of the augmentation method using HA granules and summarize our data from the biomechanical analysis of augmentation for PPS fixation. We also review the surgical outcomes of PPS fixation with augmentation using HA granules.
Clinical outcome of porous hydroxyapatite/collagen graft on bone defects following curettage of bone tumors. International-journal

Jun Iwatsu, Munenori Watanuki, Shinichirou Yoshida, Shin Hitachi, Mika Watanabe, Toshimi Aizawa

Journal of biomedical materials research. Part B, Applied biomaterials　110　(10)　2211-2216　2022/04/19

DOI： 10.1002/jbm.b.35070 　

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Hydroxyapatite/collagen (HAp/col) has been reported to be a highly useful bone-like nanocomposite. This study included 33 human patients to investigate the details of the clinical outcomes, which are (1) onset of timing of bone regeneration, (2) replacement by regenerated bone of HAp/col and (3) complications, in human cases grafting HAp/col in large bone defects, following curettage of bone tumors. Porous HAp/col initiated bone regeneration approximately 59 days following the surgery. In 15 cases (45%), complete replacement by newly formed bone was observed 12 months after surgery. On the other hand, incomplete replacement of HAp/col at the final follow-up was observed in 13 cases (39%). In these cases, HAp/col could not be detected in the transparent area of postoperative plain radiographs owing to quick absorption; moreover, it was difficult to distinguish whether the transparent area in plain radiographs was remaining HAp/col, recurrence, or remaining tumor. In addition, larger HAp/col implantation volume (≧15 cm3 ) was associated with poorer result of complete replacement (log-rank, p = .005). Further studies are warranted for the construction of a new artificial bone graft substitute that is more quickly and surely regenerated by newly formed bone in large bone defects.
Chaperone-Mediated Autophagy in Neurodegenerative Diseases and Acute Neurological Insults in the Central Nervous System. International-journal

Haruo Kanno, Kyoichi Handa, Taishi Murakami, Toshimi Aizawa, Hiroshi Ozawa

Cells　11　(7)　2022/04/02

DOI： 10.3390/cells11071205 　

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Autophagy is an important function that mediates the degradation of intracellular proteins and organelles. Chaperone-mediated autophagy (CMA) degrades selected proteins and has a crucial role in cellular proteostasis under various physiological and pathological conditions. CMA dysfunction leads to the accumulation of toxic protein aggregates in the central nervous system (CNS) and is involved in the pathogenic process of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Previous studies have suggested that the activation of CMA to degrade aberrant proteins can provide a neuroprotective effect in the CNS. Recent studies have shown that CMA activity is upregulated in damaged neural tissue following acute neurological insults, such as cerebral infarction, traumatic brain injury, and spinal cord injury. It has been also suggested that various protein degradation mechanisms are important for removing toxic aberrant proteins associated with secondary damage after acute neurological insults in the CNS. Therefore, enhancing the CMA pathway may induce neuroprotective effects not only in neurogenerative diseases but also in acute neurological insults. We herein review current knowledge concerning the biological mechanisms involved in CMA and highlight the role of CMA in neurodegenerative diseases and acute neurological insults. We also discuss the possibility of developing CMA-targeted therapeutic strategies for effective treatments.
Lumbar radiculopathy due to Bertolotti's syndrome: Alternative method to reveal the "hidden zone" - A report of two cases and review of literature.

Shigeaki Kojo, Kohei Takahashi, Takumi Tsubakino, Ko Hashimoto, Toshimi Aizawa, Yasuhisa Tanaka

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2022/03/16

DOI： 10.1016/j.jos.2022.02.004 　
人工股関節置換術の術中関節可動域と術後の靴下の着脱・爪切り動作の満足度についての検討

田中秀達, 山田則一, 栗島宏明, 坂本敬, 森優, 大沼正宏, 大山正瑞, 相澤俊峰, 北純

日本整形外科学会雑誌　96　(3)　S565-S565　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
反復性肩関節前方脱臼に合併する関節窩骨欠損各骨欠損型の特徴

藍澤一穂, 山本宣幸, 川上純, 木村礼, 品川清嗣, 永元英明, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　96　(2)　S243-S243　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
股関節内旋制動における外旋筋や後方関節包の機能が、股関節屈曲角度で異なるか Cadaverを用いた研究

馬場一慈, 千葉大介, 森優, 桑原功行, 小暮敦史, 菅谷岳広, 鈴木貴之, 栗島宏明, 浜田壮志, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S805-S805　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊椎後彎症患者の歩行時と立位時の股関節肢位三次元動作解析装置を用いた歩行解析とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S754-S754　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊椎矢状面アライメントと股関節矢状面アライメントの関係

馬場一慈, 高橋康平, 石川圭佑, 藤田涼, 秋貴史, 大野木孝嘉, 橋本功, 関口雄介, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(2)　S193-S193　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊椎後彎症患者の歩行時と立位時の股関節肢位三次元動作解析装置を用いた歩行解析とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S754-S754　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
前額断MRIによる腰椎椎間孔部狭窄の診断の信頼性と再現性 T1・T2強調画像の信頼性・再現性の比較

橋本功, 田中靖久, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 古泉豊, 国分正一, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S762-S762　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の除圧効果に関連する因子の検討

高橋康平, 橋本功, 大野木孝嘉, 菅野晴夫, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S1046-S1046　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
術前MRIによるEden分類2型と3型の脊髄砂時計腫の鑑別

木村礼, 橋本功, 大野木孝嘉, 高橋康平, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S1135-S1135　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
視距離と頭部傾斜角による脊柱矢状面アライメントの推定情報端末作業時のメガネ装着型姿勢モニタリング装置開発にむけて

橋本功, 高橋佑生, 高橋康平, 大野木孝嘉, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S1183-S1183　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
メタローシスに対して二期的に人工膝関節再置換術を行った関節リウマチの一例

古山和樹, 森優, 上村雅之, 相澤俊峰

日本リウマチ学会北海道・東北支部学術集会抄録集　31回　56-56　2022/01
Publisher: (一社)日本リウマチ学会-北海道・東北支部
Evaluation of the usefulness of the Synovasure alpha-defensin lateral flow test kit for the diagnosis of periprosthetic joint infection in Japanese patients

Yu Mori, Ryuichi Kanabuchi, Kazayoshi Baba, Daisuke Chiba, Masayuki Kamimura, Naoko Mori, Toshimi Aizawa

Journal of Orthopaedic Science　27　(4)　935-938　2022

DOI： 10.1016/j.jos.2022.05.001 　

ISSN： 0949-2658

eISSN： 1436-2023
Adolescent-onset Local Kyphosis with Anterior Column Hypoplasia and Subluxation of the Facet Joints of the Lumbar Spine: A Case Report. International-journal

Kohei Takahashi, Ko Hashimoto, Takahiro Onoki, Kyoichi Handa, Haruo Kanno, Toshimi Aizawa

Journal of orthopaedic case reports　12　(1)　50-53　2022/01

DOI： 10.13107/jocr.2022.v12.i01.2614 　

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Introduction: Hypoplasia of the anterior portion of the vertebral body is a relatively rare subtype of juvenile vertebral deformity. The common manifestations of this type of deformity are scoliosis and kyphoscoliosis, while kyphosis without scoliosis is rare. Here, we present a very rare case of adolescent-onset local kyphosis with anterior column hypoplasia and subluxation of the facet joints of the lumbar spine, as demonstrated by dynamic lateral radiograms, which was successfully treated by spine-shortening osteotomy. Case Report: A 16-year-old male adolescent presented with low back pain with progressive protrusion of the lumbar spinous process 3 years before the first visit. The protrusion was not found in his back until the age of 13 years. His chief complaint was lower back pain and a protruding spinous process in the upper lumbar spine. The anteroposterior radiogram of the whole spine revealed no obvious scoliosis. The lateral radiogram showed hypoplasia of the anterior portion of the L2 vertebral body with local kyphosis at L1-3 of 23°. The global alignment was posteriorly shifted, with hypokyphosis of the thoracic spine and hyperlordosis of the lower lumbar spine. In the dynamic lateral radiograms, the facet joints at the L2-3 spinal level were subluxated in the flexed position. Computed tomography showed symmetrical hypoplasia of the anterior portion of the vertebral body of L2. Spine-shortening osteotomy at L2 and L1-3 posterior fusion was performed for local stabilization and correction of sagittal malalignment. The lateral radiogram at the 2-year post-operative follow-up demonstrated that the global alignment was normal, with local kyphosis at L1-3 of -2°. The improvement of hypokyphosis of the thoracic spine and hyperlordosis of the lower lumbar spine was achieved. Conclusions: Adolescent-onset local lumbar kyphosis with anterior column hypoplasia and segmental subluxation of the facet joints is very rare. Local correction by spine-shortening osteotomy with short fusion can also improve the global alignment.
Imaging diagnosis of lumbar foraminal stenosis in the fifth lumbar nerve root: reliability and reproducibility of T1-weighted three-dimensional lumbar MRI. International-journal

Ko Hashimoto, Yasuhisa Tanaka, Takumi Tsubakino, Takeshi Hoshikawa, Tomowaki Nakagawa, Takashi Inawashiro, Kohei Takahashi, Masaru Suda, Toshimi Aizawa

Journal of spine surgery (Hong Kong)　7　(4)　502-509　2021/12

DOI： 10.21037/jss-21-63 　

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BACKGROUND: Various magnetic resonance imaging (MRI) techniques have been reported in detection of lumbar foraminal stenosis (LFS), especially for T2-weighted three-dimensional MRI (3D-MRI) describing the shape of nerve roots. The detection of LFS in the fifth lumbar nerve root (L5 root), however, is still less reliable compared to other lumbar nerve roots. Then we have been using T1-weighted 3D-MRI aiming to depict the shape of, and also pathology affecting the L5 root. The aim of this study is to evaluate our T1-weighted 3D-MRI in diagnosing LFS of the L5 root. METHODS: This retrospective study included 24 patients with intracanal stenosis (ICS) at L4-5, and 30 patients with LFS at L5-S causing unilateral L5 root lesion. The pre-operative T1-weighted 3D-MRI aiming bilateral L5 nerve roots of each patient were blinded and reviewed twice by five spine surgeons, independently. The image evaluation was performed in two conditions: (I) the symptomatic side was judged in 30 patients of LFS patients, and (II) the symptomatic side or the absence of LFS was judged in images of all the 54 patients including LFS and ICS patients. The correct-answer-rate, sensitivity and specificity of the imaging study were calculated. Also, the intra- and interobserver agreement of the imaging study by five spine surgeons were evaluated by the kappa (κ) statistics. RESULTS: For conditions (I) and (II) above, the mean correct-answer-rate was 92.3% and 69.8%, respectively. The sensitivity and specificity of the imaging study was 72.6% and 66.3%, respectively. The average of intraobserver κ-value of five examiners was 0.874 and 0.708, and the average of interobserver κ-value was 0.837 and 0.578, respectively. CONCLUSIONS: As well as previously reported T2-weighted 3D-MRI, our T1-weighted 3D-MRI was found to be reliable in diagnosing LFS of the L5 root.
Anterior decompression through a posterior approach for thoracic myelopathy caused by ossification of the posterior longitudinal ligament: a novel concept in anterior decompression and technical notes with the preliminary outcomes. International-journal

Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa

Journal of neurosurgery. Spine　1-11　2021/09/24

DOI： 10.3171/2021.4.SPINE213 　

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OBJECTIVE: Various surgical procedures are used to manage thoracic myelopathy due to ossification of the posterior longitudinal ligament (OPLL). However, the outcomes of surgery for thoracic OPLL are generally unfavorable in comparison to surgery for cervical OPLL. Previous studies have shown a significant risk of perioperative complications in surgery for thoracic OPLL. Thus, a safe and secure surgical method to ensure better neurological recovery with less perioperative complications is needed. The authors report a novel concept of anterior decompression through a posterior approach aimed at anterior shift of the OPLL during surgery rather than extirpation or size reduction of the OPLL. This surgical technique can securely achieve anterior shift of the OPLL using a curved drill, threadwire saw, and curved rongeur. The preliminary outcomes were investigated to evaluate the safety and efficacy of this technique. METHODS: This study included 10 consecutive patients who underwent surgery for thoracic OPLL. Surgical outcomes, including the ambulatory status, Japanese Orthopaedic Association (JOA) score, and perioperative complications, were investigated retrospectively. In this surgery, pedicle screws are introduced at least three levels above and below the corresponding levels. The laminae, facet joints, transverse processes, and pedicles are then removed bilaterally at levels wherein subsequent anterior decompression is performed. For anterior decompression, the OPLL and posterior portion of the vertebral bodies are partially resected using a high-speed drill with a curved burr, enabling the removal of osseous tissues just ventral to the spinal cord without retracting the dural sac. To securely shift the OPLL anteriorly, the intact PLL and posterior portion of the vertebral bodies cranial and caudal to the lesion are completely resected using a threadwire saw and/or curved rongeur. Rods are connected to the screws, and bone grafting is performed for posterolateral fusion. RESULTS: Five patients were nonambulatory before surgery, but all were able to walk at the final follow-up. The average JOA score before surgery and at the final follow-up was 3.2 and 8.8 points, respectively. Notably, the mean recovery rate of JOA score was 72%. Furthermore, no patients showed neurological deterioration postoperatively. CONCLUSIONS: The surgical technique is a useful alternative for safely achieving sufficient anterior decompression through a posterior approach and may consequently reduce the risk of postoperative neurological deterioration and improve surgical outcomes in patients with thoracic OPLL.
ビスフォスフォネートから治療変更したデノスマブの抗CCP抗体陽性関節リウマチ症例における骨関節破壊の抑制効果の検討

森優, 泉山拓也, 井樋栄二, 相澤俊峰

日本骨粗鬆症学会雑誌　7　(Suppl.1)　339-339　2021/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
反復性肩関節前方脱臼に合併する関節窩骨欠損各骨欠損型の特徴

藍澤一穂, 山本宣幸, 川上純, 井樋栄二, 木村礼, 品川清嗣, 永元英明, 相澤俊峰

東日本整形災害外科学会雑誌　33　(3)　454-454　2021/08
Publisher: 東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
低弾性率チタン合金製プレートによるウサギ脛骨骨切り部の骨癒合促進効果

伊東健太郎, 森優, 國井知典, 栗島宏明, 古口昌志, 藤盛理子, 正橋直哉, 花田修治, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　95　(8)　S1813-S1813　2021/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
筋・筋膜痛における好中球細胞外トラップの関与

鈴木一瑛, 土谷昌広, 神崎展, 吉田新一郎, 綿貫宗則, 矢部裕, 藤田涼, 高橋忠久, 萩原嘉廣, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　95　(8)　S1778-S1778　2021/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
胸腰椎緊急手術器械セットによる術前待機時間の短縮化

小野田祥人, 久志本成樹, 矢部裕, 橋本功, 相澤俊峰, 井樋栄二, 菅野晴夫

東北整形災害外科学会雑誌　64　(1)　189-189　2021/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
胸椎OPLLに対する彎曲型ドリルとT-sawを用いた新たな後方進入前方除圧安全・確実な除圧による手術成績の向上

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 高橋康平, 半田恭一, 井樋栄二

東北整形災害外科学会雑誌　64　(1)　193-193　2021/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Mid- to Long-Term Outcomes After Resection of Thoracic Dumbbell Tumors Managed by Laminectomy and Unilateral Total Facetectomy Without Instrumented Fusion. International-journal

Yuya Ishikawa, Masayuki Ohashi, Toru Hirano, Michiharu Matsuda, Takeru Akabane, Haruo Kanno, Ko Hashimoto, Kyoichi Handa, Toshimi Aizawa, Tomoto Suzuki, Yukihide Shimamura, Kei Watanabe

Global spine journal　21925682211008836-21925682211008836　2021/05/11

DOI： 10.1177/21925682211008836 　

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STUDY DESIGN: Retrospective multicenter study. OBJECTIVE: To evaluate mid- to long-term surgical outcomes of thoracic dumbbell tumors managed by laminectomy and unilateral total facetectomy without instrumented fusion. METHODS: A total of 15 patients with thoracic dumbbell tumors who underwent primary resection by laminectomy and unilateral total facetectomy without spinal instrumented fusion between 2000 and 2015 were reviewed. Patient characteristics, surgical outcomes (including spinal alignment and stability), disc degeneration, pain, disability, and health-related quality of life were evaluated. Additionally, to analyze the impact of the affected levels on these outcomes, we divided the patients into 2 groups: a middle thoracic group and a thoracolumbar group. RESULTS: The mean duration of follow-up was 100.5 months (range, 36-190 months). The affected level was T3-T4 or below in all patients. Although the local kyphosis angle (8.1° to 12.7°), thoracic kyphosis angle (25.6° to 33.9°), and coronal Cobb angle (6.6° to 9.5°) significantly increased from preoperative to the final visit (P ≤ .02), no patient demonstrated spinal instability. From magnetic resonance imaging, no patient had a worse grade of disc degeneration in the affected level than those in the adjacent levels. The percentage of patients who presented with an Oswestry disability index ≤ 22% was 80%. Moreover, the surgical region did not adversely affect the outcomes. No patient required additional surgery due to spinal instability or deformity. CONCLUSIONS: Unilateral total facetectomy without fusion to resect thoracic dumbbell tumors caused neither spinal deformity nor instability requiring additional surgery at the mid- to long-term follow-up.
Randomized trial of granulocyte colony-stimulating factor for spinal cord injury. International-journal

Masao Koda, Hideki Hanaoka, Yasuhisa Fujii, Michiko Hanawa, Yohei Kawasaki, Yoshihito Ozawa, Tadami Fujiwara, Takeo Furuya, Yasushi Ijima, Junya Saito, Mitsuhiro Kitamura, Takuya Miyamoto, Seiji Ohtori, Yukei Matsumoto, Tetsuya Abe, Hiroshi Takahashi, Kei Watanabe, Toru Hirano, Masayuki Ohashi, Hirokazu Shoji, Tatsuki Mizouchi, Norio Kawahara, Masahito Kawaguchi, Yugo Orita, Takeshi Sasamoto, Masahito Yoshioka, Masafumi Fujii, Katsutaka Yonezawa, Daisuke Soma, Hiroshi Taneichi, Daisaku Takeuchi, Satoshi Inami, Hiroshi Moridaira, Haruki Ueda, Futoshi Asano, Yosuke Shibao, Ikuo Aita, Yosuke Takeuchi, Masaya Mimura, Jun Shimbo, Yukio Someya, Sumio Ikenoue, Hiroaki Sameda, Kan Takase, Yoshikazu Ikeda, Fumitake Nakajima, Mitsuhiro Hashimoto, Fumio Hasue, Takayuki Fujiyoshi, Koshiro Kamiya, Masahiko Watanabe, Hiroyuki Katoh, Yukihiro Matsuyama, Tomohiko Hasegawa, Go Yoshida, Hideyuki Arima, Yu Yamato, Shin Oe, Daisuke Togawa, Sho Kobayashi, Koji Akeda, Eiji Kawamoto, Hiroshi Imai, Toshihiko Sakakibara, Akihiro Sudo, Yasuo Ito, Takeshi Kikuchi, Tomoyuki Takigawa, Takuya Morita, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Shinji Kotaka, Hideo Baba, Tsuyoshi Okudaira, Hiroaki Konishi, Takayuki Yamaguchi, Keigo Ito, Yoshito Katayama, Taro Matsumoto, Tomohiro Matsumoto, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Toshimitsu Eto, Takehiro Sugaya, Michiharu Matsuda, Kazunari Fushimi, Satoshi Nozawa, Chizuo Iwai, Toshihiko Taguchi, Tsukasa Kanchiku, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Takashi Sakai, Yasuaki Imajo, Masashi Yamazaki

Brain : a journal of neurology　144　(3)　789-799　2021/04/12

DOI： 10.1093/brain/awaa466 　

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Attenuation of the secondary injury of spinal cord injury (SCI) can suppress the spread of spinal cord tissue damage, possibly resulting in spinal cord sparing that can improve functional prognoses. Granulocyte colony-stimulating factor (G-CSF) is a haematological cytokine commonly used to treat neutropenia. Previous reports have shown that G-CSF promotes functional recovery in rodent models of SCI. Based on preclinical results, we conducted early phase clinical trials, showing safety/feasibility and suggestive efficacy. These lines of evidence demonstrate that G-CSF might have therapeutic benefits for acute SCI in humans. To confirm this efficacy and to obtain strong evidence for pharmaceutical approval of G-CSF therapy for SCI, we conducted a phase 3 clinical trial designed as a prospective, randomized, double-blinded and placebo-controlled comparative trial. The current trial included cervical SCI [severity of American Spinal Injury Association (ASIA) Impairment Scale (AIS) B or C] within 48 h after injury. Patients are randomly assigned to G-CSF and placebo groups. The G-CSF group was administered 400 μg/m2/day × 5 days of G-CSF in normal saline via intravenous infusion for five consecutive days. The placebo group was similarly administered a placebo. Allocation was concealed between blinded evaluators of efficacy/safety and those for laboratory data, as G-CSF markedly increases white blood cell counts that can reveal patient treatment. Efficacy and safety were evaluated by blinded observer. Our primary end point was changes in ASIA motor scores from baseline to 3 months after drug administration. Each group includes 44 patients (88 total patients). Our protocol was approved by the Pharmaceuticals and Medical Device Agency in Japan and this trial is funded by the Center for Clinical Trials, Japan Medical Association. There was no significant difference in the primary end point between the G-CSF and the placebo control groups. In contrast, one of the secondary end points showed that the ASIA motor score 6 months (P = 0.062) and 1 year (P = 0.073) after drug administration tend to be higher in the G-CSF group compared with the placebo control group. Moreover, in patients aged over 65 years old, motor recovery 6 months after drug administration showed a strong trend towards a better recovery in the G-CSF treated group (P = 0.056) compared with the control group. The present trial failed to show a significant effect of G-CSF in primary end point although the subanalyses of the present trial suggested potential G-CSF benefits for specific population.
A Right Angle Guide for Distal Tuberosity Osteotomy With Medial Open Wedge High Tibial Osteotomy for Varus Knee Osteoarthritis. International-journal

Akira Sasaki, Takehiko Sugita, Nobuyuki Itaya, Toshimi Aizawa, Naohisa Miyatake, Seiya Miyamoto, Ikuo Maeda, Masayuki Kamimura, Atsushi Takahashi, Hideaki Nagamoto

Arthroscopy techniques　10　(4)　e1007-e1016　2021/04

DOI： 10.1016/j.eats.2020.11.017 　

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Medial open wedge high tibial osteotomy (OWHTO) is usually performed with proximal tuberosity osteotomy or setting the osteotomy line proximal to the tuberosity. However, OWHTO can result in patellofemoral complications due to postoperative patella infera. A new OWHTO technique, biplanar osteotomy with a distal tuberosity osteotomy, was reported in 2004 to prevent postoperative patella infera. To ensure that the 2 osteotomy lines maintain perpendicular, we describe the OWHTO procedure with a distal tuberosity osteotomy technique using a TriS Medial HTO Plate System (Olympus Terumo Biomaterials Corp., Tokyo, Japan) and a right angle guide we developed. In this Technical Note, we describe the procedure and advantages, risks, and limitations, as well as the pearls and pitfalls based on our experience.
胸椎後縦靱帯骨化症に対する後方進入前方除圧術(大塚変法)の手術成績とCTによる除圧の検証

高橋康平, 相澤俊峰, 橋本功, 小野田祥人, 半田恭一, 大野木孝嘉, 菅野晴夫, 小澤浩司

Journal of Spine Research　12　(3)　96-96　2021/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
胸椎OPLLに対する彎曲型ドリルとT-sawを用いた新たな後方進入前方除圧安全・確実な除圧が術後の麻痺悪化を回避し早期離床を可能にする

菅野晴夫, 相澤俊峰, 橋本功, 高橋康平, 半田恭一, 井樋栄二, 小澤浩司

Journal of Spine Research　12　(3)　179-179　2021/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
前額断MRIによる腰椎椎間孔部狭窄の診断 T1・T2強調画像の信頼性・再現性と読影傾向の比較検証

橋本功, 田中靖久, 相澤俊峰, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 両角直樹, 古泉豊, 佐藤哲朗, 小澤浩司, 菅野晴夫, 国分正一, 井樋栄二

Journal of Spine Research　12　(3)　359-359　2021/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
成人脊柱変形に対するdynamic compression hookを併用した脊柱短縮骨切り術変形矯正効果とロッド折損予防の検討

菅野晴夫, 相澤俊峰, 橋本功, 小澤浩司

Journal of Spine Research　12　(3)　394-394　2021/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
脊髄神経鞘腫摘出術における神経根切離後の神経脱落症状の検討

半田恭一, 相澤俊峰, 村上大史, 大野木孝嘉, 高橋康平, 橋本功, 小澤浩司, 井樋栄二

Journal of Spine Research　12　(3)　429-429　2021/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
硬膜内髄外腫瘍における神経鞘腫と髄膜腫のMRI鑑別アルゴリズムの有効性

村上大史, 相澤俊峰, 半田恭一, 大野木孝嘉, 鈴木学, 高橋康平, 小野田祥人, 橋本功, 小澤浩司, 井樋栄二

Journal of Spine Research　12　(3)　433-433　2021/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の成績後方除圧固定術との比較

相澤俊峰, 橋本功, 高橋康平, 大野木孝嘉, 半田恭一, 菅野晴夫, 小澤浩司

Journal of Spine Research　12　(3)　592-592　2021/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
脊椎手術における温風式加温装置の術中使用はSSI発生リスクか傾向スコアマッチング法を用いた検討

半田恭一, 菅野晴夫, 松谷重恒, 大野木孝嘉, 高橋康平, 橋本功, 相澤俊峰, 井樋栄二

日本整形外科学会雑誌　95　(3)　S705-S705　2021/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
前額断MRIによる腰椎椎間孔部狭窄の診断 T1・T2強調画像の信頼性・再現性と読影傾向の比較検証

橋本功, 田中靖久, 相澤俊峰, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 両角直樹, 古泉豊, 佐藤哲朗, 小澤浩司, 菅野晴夫, 国分正一, 井樋栄二

Journal of Spine Research　12　(3)　359-359　2021/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
Retrospective comparison of the surgical results for patients with thoracic myelopathy caused by ossification of the posterior longitudinal ligament: Posterior decompression with instrumented spinal fusion versus modified anterior decompression through a posterior approach.

Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Kyoichi Handa, Kohei Takahashi, Takahiro Onoki, Eiji Itoi, Hiroshi Ozawa

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　27　(2)　323-329　2021/02/07

DOI： 10.1016/j.jos.2021.01.001 　

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BACKGROUND: In Japan, approximately 75% of patients with thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) are treated by posterior decompression with instrumented spinal fusion (PDF) because of its efficacy and safety. To achieve more effective decompression of the spinal cord using a posterior approach, anterior decompression through a posterior approach was developed. However, this technique has a high risk of postoperative paralysis. We have added a couple of ingenuities to this procedure (modified Ohtsuka procedure). This study was performed to report the surgical results of our modified Ohtsuka procedure and to compare them with the results of PDF. METHODS: This was a retrospective case series. From 2008 to 2018, we surgically treated 32 patients: 20 patients treated by PDF (PDF group) and 12 patients by our modified Ohtsuka procedure (modified Ohtsuka group) as the initial surgery. All patients were followed up for at least 12 months. The degree of surgical invasion and patients' neurological condition were assessed. RESULTS: The operative duration and intraoperative blood loss indicated no significant differences (PDF vs. Ohtuska: 507 ± 103 vs. 534 ± 99 min, 1022 ± 675 vs. 1160 ± 685 ml, respectively). The preoperative Japanese Orthopaedic Association (JOA) score was 4.5 ± 2.0 in the PDF group and 3.3 ± 1.4 in the modified Ohtsuka group (p < 0.05). However, the latest JOA score and recovery rate were significantly better in the modified Ohtsuka group than in the PDF group (8.9 ± 1.2 vs. 7.4 ± 2.5 and 70.8 ± 17.6% vs. 44.5 ± 40.2%, respectively). Postoperative paralysis did not occur in the modified Ohtsuka group while four patients had it in the PDF group. CONCLUSIONS: The present study clearly indicated the modified Ohtsuka group showed significantly better surgical outcomes than the PDF group with the recovery rate ≥70%.
Posterior osteotomy and reconstruction for osteoporotic vertebral collapse

Hiroshi Ozawa, Yasuhisa Tanaka, Toshimi Aizawa, Haruo Kanno, Shoichi Kokubun

Osteoporosis Of The Spine: Asian Perspectives　582-590　2021/01/19
Publisher: World Scientific Publishing Co.
DOI： 10.1142/9789811220814_0025 　
Surgical management of facet cysts in the thoracic spine: Radiological manifestations and results of fenestration

Takashi Kusakabe, Toshimi Aizawa, Fumio Kasama, Takeshi Nakamura, Akira Sekiguchi, Takeshi Hoshikawa, Yutaka Koizumi

Journal of Orthopaedic Science　2021
Publisher: Elsevier B.V.
DOI： 10.1016/j.jos.2021.07.007 　

ISSN： 1436-2023 0949-2658
Surgical outcomes of patients with sacroiliac joint pain: An analysis of patients with poor results regarding activities of daily living

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa, Takashi Watanabe

Spine Surgery and Related Research　5　(3)　189-195　2021
Publisher: Japanese Society for Spine Surgery and Related Research
DOI： 10.22603/SSRR.2020-0214 　

ISSN： 2432-261X
Novel augmentation technique of percutaneous pedicle screw fixation using hydroxyapatite granules in the osteoporotic lumbar spine: a cadaveric biomechanical analysis. International-journal

Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　30　(1)　71-78　2021/01

DOI： 10.1007/s00586-020-06451-2 　

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PURPOSE: Percutaneous pedicle screw (PPS) fixation has been commonly used for various spine surgeries. Rigid PPS fixation is necessary to decrease the incidence of screw loosening in osteoporotic spine. Recently, we have reported biomechanical advantages of augmentation technique using hydroxyapatite (HA) granules for PPS fixation in synthetic bone. However, its biomechanical performance in augmenting PPS fixation for osteoporotic spine has not been fully elucidated. The aim of the present study is to perform a cadaveric biomechanical analysis of PPS fixation augmented with HA granules. METHODS: Thirty osteoporotic lumbar vertebrae (L1-L5) were obtained from 6 cadavers (3 men and 3 women; age 80 ± 9 years; bone mineral density 73 ± 9 mg/cm3). The maximal pullout strength and maximal insertion torque were compared between the screws inserted into the vertebrae with and without augmentation. In toggle testing, the number of craniocaudal toggle cycles and maximal load required to achieve the 2-mm screw head displacement were also compared. RESULTS: The maximal pullout strength in the screws augmented with HA granules was significantly greater compared to those without augmentation (p < 0.05). The augmentation significantly increased the maximal insertion torque of the screws (p < 0.05). Moreover, the number of toggle cycles and the maximal load required to reach 2 mm of displacement were significantly higher in the augmented screws (p < 0.05). CONCLUSION: The PPS fixation was significantly enhanced by the augmentation with HA granules in the osteoporotic lumbar spine. The PPS fixation augmented with HA granules might decrease the incidence of screw loosening and implant failure in patients with osteoporotic spine.
Surgical results of nonambulatory patients caused by ossification of the posterior longitudinal ligaments in the thoracic spine: retrospective comparative study between posterior decompression and instrumented spinal fusion versus anterior decompression through a posterior approach. International-journal

Toshimi Aizawa, Toshimitsu Eto, Ko Hashimoto, Haruo Kanno, Eiji Itoi, Hiroshi Ozawa

Journal of neurosurgery. Spine　34　(3)　1-6　2020/12/11

DOI： 10.3171/2020.7.SPINE20411 　

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OBJECTIVE: Thoracic myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) remains one of the most difficult-to-treat disorders for spine surgeons. In Japan, approximately 75% of patients with this condition are treated using posterior decompression with instrumented spinal fusion (PDF). In contrast, anterior decompression is the most effective method for relieving spinal cord compression. The authors treated nonambulatory patients with thoracic OPLL by either PDF or by their technique using anterior decompression through a posterior approach. In this study the surgical results of these procedures are compared. METHODS: This was a retrospective case series. From 2008 to 2018, 9 patients with thoracic OPLL who could not walk preoperatively were treated surgically. Three patients were treated by PDF (the PDF group) and 6 patients were treated by anterior decompression through a posterior approach (the modified Ohtsuka group). The degree of surgical invasion and the neurological conditions of the patients were assessed. RESULTS: The PDF group had a shorter operative duration (mean 477 ± 122 vs 569 ± 92 minutes) and less intraoperative blood loss (mean 613 ± 380 vs 1180 ± 614 ml), although the differences were not statistically significant. The preoperative Japanese Orthopaedic Association (JOA) score was almost identical between the two groups; however, the latest JOA score and the recovery rate were significantly better in the modified Ohtsuka group than in the PDF group (8.8 ± 1.5 vs 5.0 ± 1.7 and 71.3% ± 23.7% vs 28.3% ± 5.7%, respectively). The walking ability was evaluated using the modified Frankel scale. According to this scale, 3 patients showed three grade improvements, 2 patients showed two grade improvements, and 1 patient showed one grade improvement in the modified Ohtsuka group. Three patients in the modified Ohtsuka group could walk without any support at the final follow-up. CONCLUSIONS: The present study clearly indicated that the surgical outcomes of the authors' modified Ohtsuka procedure were significantly better than those of PDF for patients who could not walk preoperatively.
Rate of spinal surgery in a rapidly aging society: the 27-year changes in Miyagi prefecture, Japan. International-journal

Toshimi Aizawa, Shoichi Kokubun, Takashi Kusakabe, Hiroshi Ozawa, Yasuhisa Tanaka, Takeshi Hoshikawa, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yutaka Koizumi, Chikashi Kawahara, Tetsuro Sato, Hironori Hyodo, Shinji Ogawa, Eiichi Murakami, Eiji Itoi

Journal of neurosurgical sciences　64　(6)　525-530　2020/12

DOI： 10.23736/S0390-5616.18.04251-0 　

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BACKGROUND: Japan has had a rapidly aging population during the past 30 years. This study aimed to investigate longitudinal changes in the surgical rate for spinal disorders in Miyagi Prefecture (2.35 million inhabitants) with a similar population composition to Japan. METHODS: Data of spinal surgeries were collected using the spine registry by Tohoku University Spine Society. Data on the annual number of spinal surgeries between 1988 and 2014 of all populations, in those aged ≥65 years old, in those aged ≥75 years old, and for each pathology were collected. The annual surgical rate per 100,000 inhabitants was calculated. RESULTS: The surgical rate in 2010-2014 in total, at ≥65 years old, and at ≥75 years old showed 3.2-, 3.8- and 7.1-fold increases, respectively, compared with that in 1988-1989. Degenerative spinal disorders, spinal trauma and pyogenic spondylitis markedly increased, while metastatic spinal tumor and tuberculous spondylitis decreased over time. The surgical rate at ≥75 years with lumbar spinal stenosis showed a 12.6-time increase. CONCLUSIONS: During a rapid period of aging, the rate of spinal surgeries has markedly increased, particularly, that for degenerative disorders. This is the first report on the long-term longitudinal changes in the rate of spinal surgery.
Anterior Decompression and Fusion Versus Laminoplasty for Cervical Myelopathy Caused by Soft Disk Herniation: A Long-term Prospective Multicenter Study. International-journal

Tomoaki Koakutsu, Toshimi Aizawa, Morichika Sasaki, Akira Sekiguchi, Naoki Morozumi, Yushin Ishii, Shoichi Kokubun, Ko Hashimoto, Fumio Kasama, Yasuhisa Tanaka, Tetsuro Sato, Eiji Itoi, Shin Yamazaki

Clinical spine surgery　33　(10)　E478-E485　2020/12

DOI： 10.1097/BSD.0000000000000986 　

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STUDY DESIGN: A prospective multicenter study. OBJECTIVE: The purpose of this study was to determine whether laminoplasty (LP) is comparable for myelopathy caused by cervical disk herniation (CDH). SUMMARY OF BACKGROUND DATA: Anterior decompression and fusion (ADF) has conventionally been used for myelopathy caused by CDH with stable outcomes. However, recurrence of myelopathy due to adjacent segment degeneration are its drawbacks. The efficacy of LP without discectomy has been sporadically reported, but no long-term prospective study has been conducted to verify it. MATERIALS AND METHODS: Patients with cervical myelopathy caused by CDH were studied. The first 30 patients and the next 30 patients were treated with ADF and LP, respectively. The outcomes were compared between the 22 ADF patients and the 20 LP patients who had completed the follow-up examination scheduled 10 years after surgery. RESULTS: There was no statistically significant difference in the postoperative severity or recovery rate of myelopathy between the 2 groups 10 years after surgery. One patient in the ADF group underwent LP for secondary myelopathy due to adjacent segment degeneration 2 years after the surgery. Reoperation was not required for patients in the LP group. Postoperative neck pain was significantly more severe in the LP group than in the ADF group. CONCLUSIONS: ADF and LP for cervical myelopathy caused by CDH achieve similarly favorable outcomes. Recurrence of myelopathy caused by adjacent segment degeneration is a disadvantage of ADF while residual neck pain is a disadvantage of LP.
Obesity is a risk factor for osteoarthritis progression and spontaneous osteoporosis is a risk for the development of spontaneous osteonecrosis in patients with medial meniscus posterior root tear.

Atsushi Takahashi, Jutaro Umehara, Masayuki Kamimura, Toshimi Aizawa, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2020/10/05

DOI： 10.1016/j.jos.2020.09.001 　

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BACKGROUND: Obesity is a representative risk factor for osteoarthritis (OA). The relationship between osteoporosis and executed osteonecrosis has been reported. The primary aim of this study was to determine the influence of obesity and osteoporosis on disease progression in patients with medial meniscus posterior root tear (MMPRT). METHODS: We included 41 knees with MMPRT in this study. MMPRT was diagnosed based on the presence of both a meniscus ghost sign and a vertical linear defect on MRI. OA progression and development of osteonecrosis were evaluated using plain radiographs obtained at the initial visit and the final follow-up. The follow-up period for all knees was 30 ± 8 (mean ± standard deviation) months. Patients' physical attributes were assessed at initial visits; these attributes included body mass index (BMI) and the clinical risk for osteoporotic fracture, as determined by the World Health Organization fracture risk assessment tool (FRAX). Patients with a BMI ≥25 kg/m2 were classified in the obesity group and those with a BMI <25 kg/m2 in the control group. Patients with a FRAX score of ≥10% were classified in the high FRAX group and those with a FRAX score of <10% in the low FRAX group. RESULTS: OA progression evaluated by Kellgren-Lawrence grading scale was observed in 75% patients in the obesity group (1 grade in 38%, 2 grades in 31%, and 3 grades in 6%) and 58% in the control group (1 grade in 58%). Patients in the obesity group showed significantly greater OA progression. Spontaneous osteonecrosis was observed in no knees at the initial visit and six knees at the final follow-up. All six lesions were observed in the high FRAX group, which was statistically significant. CONCLUSIONS: OA progression and development of osteonecrosis were the two representative deterioration patterns in patients with MMPRT. High BMI was related with OA progression, and FRAX score of ≥10% with the development of osteonecrosis.
化膿性脊椎炎術後に非閉塞性腸管虚血症を発症した1例

佐藤宏陽, 相澤俊峰, 橋本功, 菅野晴夫, 衛藤俊光, 半田恭一, 井樋栄二

臨床整形外科　55　(10)　1177-1180　2020/10
Publisher: (株)医学書院
ISSN： 0557-0433

eISSN： 1882-1286
Criteria for Identifying Technically Difficult Cases when Performing Sacroiliac Intraarticular Injections Based on the Grade of Sacroiliac Arthrogram. International-journal

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa, Takashi Watanabe, Yutaka Yabe

Pain medicine (Malden, Mass.)　21　(10)　2105-2110　2020/10/01

DOI： 10.1093/pm/pnaa120 　

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OBJECTIVE: An intraarticular sacroiliac joint (SIJ) injection cannot always be performed successfully. Based on the patterns of the sacroiliac arthrogram, we explored possible indicators of technically difficult and technically easy injections into the SIJ including demographic features and anatomical features evident on preprocedural imaging. DESIGN: Observational study. METHODS: We evaluated 76 patients with painful SIJ (total 108 joints) diagnosed by SIJ injections. The sacroiliac arthrogram was graded as follows: Grade (G) 0 = the margin of the joint was partially outlined; G1 = the margin was completely outlined; G2 = intraarticular space was substantially outlined; and G3 = intraarticular space was fully outlined. Two multivariable ordered logistic regression analyses were performed to test the relationships between gender, age, and Grade, as well as between computed tomography (CT) findings and grade. RESULTS: In men, the totals by Grade were G0 = 8 (joints); G1 = 33; G2 = 3; and G3 = 0. In women, these were G0 = 4; G1 = 28; G2 = 22; and G3 = 10. The Grade was significantly higher in women and was also higher with age (P < 0.05). Regarding morphological features in CT, minor osteophytes increased the odds in favor of better Grades of arthrogram (odds ratio = 3.50). Substantial vacuum phenomena strongly increased the odds of better arthrograms (20.52). CONCLUSIONS: Outlining the SIJ cavity fully is significantly more difficult in male patients of any age than in aged female patients. The presence of minor osteophytes and substantial vacuum phenomena on preprocedure CT scans can be reasonably reassuring to the practitioner that they are unlikely to encounter difficulties during injection.
腰痛のない健常中高年者229名における腰椎不安定性

鈴木学, 田中靖久, 橋本功, 相澤俊峰, 椿野巧, 星川健, 高橋康平, 三宅公太, 小城繁明, 金城英傑, 井樋栄二

日本整形外科学会雑誌　94　(8)　S1910-S1910　2020/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
自然縮小した胸椎部砂時計腫の1例

鈴木学, 相澤俊峰, 橋本功, 菅野晴夫, 小野田祥人, 井樋栄二

東日本整形災害外科学会雑誌　32　(2)　198-201　2020/06
Publisher: 東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の手術成績

相澤俊峰, 橋本功, 菅野晴夫, 半田恭一, 小野田祥人, 井樋栄二, 小澤浩司

Journal of Spine Research　11　(3)　217-217　2020/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
胸椎後縦靱帯骨化症に対する後方進入前方除圧術の新たな工夫彎曲型ドリルとT-sawによる安全・確実な前方除圧

菅野晴夫, 相澤俊峰, 橋本功, 衛藤俊光, 井樋栄二

Journal of Spine Research　11　(3)　219-219　2020/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
固定術を併用しない胸椎砂時計腫摘出術の中長期成績多施設研究

石川裕也, 大橋正幸, 平野徹, 松田倫治, 赤羽武, 菅野晴夫, 橋本功, 半田恭一, 相澤俊峰, 鈴木智人, 嶋村之秀, 渡辺慶

Journal of Spine Research　11　(3)　517-517　2020/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
腰椎不安定性と腰痛の関連 189例の健常者による前向き研究

鈴木学, 田中靖久, 橋本功, 相澤俊峰, 椿野巧, 星川健, 高橋康平, 三宅公太, 小城繁明, 金城英傑, 井樋栄二

日本整形外科学会雑誌　94　(2)　S118-S118　2020/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
胸椎後縦靱帯骨化症の手術成績後方除圧固定術と後方進入前方除圧術の比較

相澤俊峰, 橋本功, 菅野晴夫, 衛藤俊光, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　94　(3)　S936-S936　2020/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Spontaneous Resorption of Intradural Lumbar Disc Herniation: A Rare Case Report.

Naoki Morozumi, Toshimi Aizawa, Morichika Sasaki, Yutaka Koizumi, Shoichi Kokubun

Spine surgery and related research　4　(3)　277-279　2020

DOI： 10.22603/ssrr.2019-0074 　
Accurate and Minimally Invasive Cervical Pedicle Screw Insertion Procedure Using the Bone Biopsy Needle as Drill Guide.

Tomoaki Koakutsu, Toshimi Aizawa, Eiji Itoi

Spine surgery and related research　4　(4)　358-364　2020

DOI： 10.22603/ssrr.2019-0114 　

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Introduction: Cervical pedicle screw (CPS) fixation provides the strongest mechanical stability. It needs, however, wide soft tissue detachment to expose the entry point and carries the potential risk of iatrogenic damage to neurovascular structures. Malposition of the CPS cannot be completely avoided even using the navigation system. Technical Note: Using the bone biopsy needle as drill guide, we developed a novel accurate CPS insertion technique. (1) The entry point of CPS was exposed using Southwick's technique for anterior fixation or Tokioka's technique for posterior fixation. (2) A 13G bone biopsy needle was inserted from the entry point established by the fluoroscopy-assisted pedicle axis view technique described by Yukawa et al. to within a few millimeters of the pedicle. (3) The external sleeve of the bone biopsy needle was left in place as a drill guide, and the 1.25 mm guidewire for a 4.0 mm cannulated screw was then inserted into the pedicle cavity. (4) The external sleeve of the bone biopsy needle was removed, and the screw trajectory was created by a 2.7 mm cannulated drill bit over the guidewire. (5) Tapping was conducted prior to CPS insertion. Using this method, 29 CPSs in nine patients were inserted. Postoperative computed tomography scans revealed that all the CPSs were placed accurately. Conclusions: Utilizing the bone biopsy needle as drill guide, our procedure enables accurate positioning of CPS without expensive instruments.
Quality of life after staged bilateral total knee arthroplasty: a minimum five-year follow-up study of seventy-eight patients. International-journal Peer-reviewed

Takehiko Sugita, Naohisa Miyatake, Toshimi Aizawa, Akira Sasaki, Masayuki Kamimura, Atsushi Takahashi

International orthopaedics　43　(10)　2309-2314　2019/10

DOI： 10.1007/s00264-018-4196-0 　

ISSN： 0341-2695

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PURPOSE: Although many studies have been performed to evaluate the quality of life (QOL) and patient satisfaction after total knee arthroplasty (TKA), almost all evaluations were performed in patients after unilateral TKA or in patients after mixed unilateral and bilateral TKA. Accordingly, this study aimed to evaluate QOL after staged bilateral TKA. METHODS: A total of 78 patients who underwent staged bilateral TKA for varus knee osteoarthritis were included in this study. All patients had longitudinal follow-up evaluations for at least five years. QOL was assessed by the Japanese Knee Osteoarthritis Measure (JKOM), a disease-specific and patient-derived QOL measure for Japanese patients. Conventional objective outcome scales, including the Knee Society Score and the Timed Up and Go test, were also assessed. In addition, QOL and objective outcomes were compared between the younger (≤ 80 years, average 75.8 years) and older (> 80 years, average 84.7 years) age groups at the final follow-up. RESULTS: Improvements in both JKOM and objective outcomes reached a plateau one year after staged bilateral TKA. Improvements were prolonged for more than five years. There were no statistically significant differences in JKOM or objective outcomes between the younger and older age groups, despite an 8.9-year difference in the average age. CONCLUSIONS: This was the first longitudinal study to evaluate QOL and objective outcomes after staged bilateral TKA for a period of at least five years. Improvements in QOL and objective outcomes reached a plateau one year after staged bilateral TKA and were prolonged for more than five years. No significant differences were observed in outcome scores between the younger and older age groups.
Several pathologies cause delayed postoperative paralysis following posterior decompression and spinal fusion for thoracic myelopathy caused by ossification of the posterior longitudinal ligament. Peer-reviewed

Toshimitsu Eto, Toshimi Aizawa, Haruo Kanno, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　27　(3)　725-733　2019/09/12

DOI： 10.1016/j.jos.2019.08.004 　

ISSN： 0949-2658
Spino-pelvic- lower extremity balance during walking in elderly patients with spinal kyphosis. Peer-reviewed

Kumi Kamata, Hiroshi Ozawa, Yusuke Sekiguchi, Toshimi Aizawa, Shinichi Izumi, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　24　(5)　793-797　2019/09

DOI： 10.1016/j.jos.2019.01.005 　

ISSN： 0949-2658

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BACK GROUND: Patients with spinal kyphosis were radiographically evaluated while standing. However, the spino-pelvic alignment during walking is different. This study examined the spino-pelvic-lower extremity alignment during walking by a three-dimensional (3D) motion analysis. METHODS: Twenty-six patients with a sagittal vertical axis of ≥4 cm (male: female, 5:21; average age, 66 years) were evaluated. Using a 3D motion capture system, the trunk and pelvic anterior inclination angles, hip and knee joint angles were measured during a 3-min walk. The correlation coefficient between the change of the trunk anterior inclination angle and each parameter at the beginning of walking was calculated, and those parameters were compared with radiographic measurements. RESULTS: The patients were divided into two groups according to the change of the trunk anterior inclination angle: the large change group included 14 patients with an increase of ≥5° between the beginning and end of the 3-min walk; the small change group included 12 patients with an increase of <5°. The pelvic anterior inclination angle showed a significant difference between the two groups at the first gait cycles. The pelvic anterior inclination angle and the hip joint angle in the large change group showed a significant difference between the first and last cycles. The correlation coefficient revealed a significant association between the change in the trunk anterior inclination angle and the pelvic anterior inclination angle at the beginning of walking. There were no significant differences between the two groups in any radiographic spino-pelvic parameters. CONCLUSIONS: There were two types of patients with spinal kyphosis: patients with a small pelvic anterior inclination angle at the beginning of walking showed slight progression in their trunk anterior inclination, whereas those with a large pelvic angle showed a large degree of progression in their pelvic and trunk inclination during walking.
Surgical Management of Giant Sacral Schwannoma: A Case Series and Literature Review. International-journal Peer-reviewed

Kyoichi Handa, Hiroshi Ozawa, Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Satoshi Tateda, Eiji Itoi

World neurosurgery　129　e216-e223-e223　2019/09

DOI： 10.1016/j.wneu.2019.05.113 　

ISSN： 1878-8750

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OBJECTIVE: Giant sacral schwannomas are rare and difficult to treat. Unexpected neurologic deficits after surgery and tumor recurrence should be considered when surgery is performed. We attempt to remove the tumors via piecemeal total or subtotal excision, leaving parts of the capsule adjacent to nerves to preserve the nerves. This study aimed to present the cases of giant sacral schwannoma at our institutions as well as review the relevant literature and to discuss surgical management. METHODS: This study included 11 patients (5 male and 6 female, mean age 53 years) with giant sacral schwannoma who were treated surgically. The clinical features, surgical details, and outcomes were investigated retrospectively. RESULTS: The tumors were intraosseous type in 4 cases, dumb-bell type in 3 cases, and retroperitoneal type in 4 cases. The surgeries were performed by a combined anterior and posterior approach in 4 cases, a posterior approach in 4 cases, and an anterior approach in 3 cases. The tumors were removed via piecemeal total or subtotal excision in 7 cases, partial excision in 3 cases, and enucleation in 1 case. After surgery, symptoms improved in all cases. The tumor recurred in 2 patients after partial excision. No patients receiving piecemeal total or subtotal excision showed recurrence. One patient developed motor weakness after piecemeal subtotal excision, but the symptoms resolved. CONCLUSIONS: Adopting an appropriate surgical approach based on the location of the tumor is important. Piecemeal total or subtotal excision, with parts of the capsule adjacent to nerves left behind may help achieve a good outcome, avoiding a postoperative neurologic deficit.
自然縮小傾向を示した胸椎部砂時計腫の1例

鈴木学, 相澤俊峰, 橋本功, 菅野晴夫, 小野田祥人, 衛藤俊光, 半田恭一, 大野木孝嘉, 井樋栄二

東日本整形災害外科学会雑誌　31　(3)　371-371　2019/08
Publisher: 東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
Destructive discovertebral degenerative diseaseの1例

松田倫治, 相澤俊峰, 橋本功, 菅野晴夫, 山屋誠司, 衛藤俊光, 半田恭一, 井樋栄二

東北整形災害外科学会雑誌　62　(1)　154-154　2019/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
東北大学脊椎外科懇話会手術登録

相澤俊峰, 国分正一, 佐藤哲朗, 田中靖久, 笠間史夫, 村上栄一, 小澤浩司, 兵藤弘訓, 古泉豊, 両角直樹, 星川健, 川原央, 小川真司, 日下部隆, 中川智刀, 橋本功, 菅野晴夫, 東北大学脊椎外科懇話会

東北整形災害外科学会雑誌　62　(1)　201-201　2019/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Adjacent segment degeneration after fusion spinal surgery-a systematic review. International-journal Peer-reviewed

Ko Hashimoto, Toshimi Aizawa, Haruo Kanno, Eiji Itoi

International orthopaedics　43　(4)　987-993　2019/04

DOI： 10.1007/s00264-018-4241-z 　

ISSN： 0341-2695

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PURPOSE: Adjacent segment degeneration (ASDeg) and disease (ASDis) have become major concerns after fusion surgery. However, there is no definitive data or knowledge about the incidence or risk factors. The review discusses the incidence and risk factors and prevention of ASDeg and ASDis in the relevant literature. METHODS: We performed a systematic review of meta-analyses, randomized control trials, and cohort studies published in English to provide evidence-based information about ASDeg and ASDis. RESULTS: According to a meta-analysis, the pooled incidence of ASDeg after lumbar and cervical fusion surgery was 26.6% and 32.8%, respectively. Approximately 1/4-1/3 of ASDeg progressed to ASDis. Risk factors after cervical fusion surgery were young age, pre-existing disc degeneration, short fusion segment, high T1 slope, disruption of adjacent soft tissue, and plate placement close to the adjacent disc. The risk factors of ASDeg and ASDis after lumbar fusion surgery were age, genetic factors, high body mass index, pre-existing adjacent segment degeneration, laminectomy at the adjacent level of fusion, excessive distraction of the fusion level, insufficient lumbar lordosis, multilevel fixation, floating fusion, coronal wedging of L5-S disc, pelvic tilt, and osteoporosis. Motion-preserving surgeries seem to have less risk of ASDeg and ASDis than conventional fusion surgery both in the lumbar and cervical spine. CONCLUSIONS: The existent literature points out variables involved in ASDeg and ASDis. High evidence-level studies should provide more relevant data to guide strategies for avoiding ASDeg and ASDis.
Minimally invasive discectomy for lumbar disc herniation: current concepts, surgical techniques, and outcomes. International-journal Peer-reviewed

Haruo Kanno, Toshimi Aizawa, Ko Hahimoto, Eiji Itoi

International orthopaedics　43　(4)　917-922　2019/04

DOI： 10.1007/s00264-018-4256-5 　

ISSN： 0341-2695

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PURPOSE: To date, various minimally invasive surgeries for lumbar disc herniation (LDH) have been performed in many countries, including microendoscopic discectomy (MED) and percutaneous endoscopic discectomy (PED). We herein report the surgical indications, current concepts, and techniques of minimally invasive discectomy for LDH, including MED and PED. The postoperative outcomes and risks of complications compared with conventional discectomy are also discussed. METHODS: By reviewing past literatures, the current concepts, surgical techniques, and clinical outcomes were described. RESULTS: Minimally invasive discectomy is generally performed using a transmuscular approach with an endoscopic technique and can reduce muscle and soft tissue damage. The minimal invasiveness can also reduce the severity of postoperative pain and improve patient satisfaction compared with conventional open discectomy. Based on the data of previous systematic reviews and meta-analyses, minimally invasive lumbar discectomy, such as MED and PED, appears to be safe and effective alternatives to open discectomy for patients with symptomatic LDH. These minimally invasive surgeries can provide beneficial effects to shorten the hospital stay and time to return to work. However, minimally invasive discectomy has a demanding learning curve. Only a well-trained surgeon and support team should perform these less invasive procedures. CONCLUSIONS: Clinical evidence supporting the superiority of MED and PED is still limited. Well-designed prospective multicentered randomized controlled trials with large samples are therefore needed in order to draw a convincing conclusion.
脊椎・脊髄外科手術に関係した遠隔脳出血の発生頻度 11年間の前向き研究

相澤俊峰, 小澤浩司, 菅野晴夫, 橋本功, 小野田祥人, 松田倫治, 井樋栄二

日本整形外科学会雑誌　93　(3)　S873-S873　2019/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Pitfalls during Sacroiliac Joint Arthrodesis for Patients with Severe Sacroiliac Joint Pain: Report of Three Cases with Sacral Dysmorphism Induced by Lumbosacral Transitional Vertebrae. International-journal

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa, Takashi Watanabe, Hiroshi Ozawa

Journal of orthopaedic case reports　10　(1)　54-57　2019

DOI： 10.13107/jocr.2019.v10.i01.1634 　

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Introduction: Lumbosacral transitional vertebrae (LSTV) can cause sacral dysmorphism. Sacroiliac joint (SIJ) arthrodesis has been widely performed as the last resort for severe SIJ pain. We report three kinds of technical pitfalls identified in the surgical records of SIJ arthrodesis for the patients with sacral dysmorphism induced by LSTV. Case Report: For the cases of a 34-year-old man with LSTV Castellvi's Type IV, anterior SIJ arthrodesis using a plate and screws was performed. The most cranial sacral foramen was larger and irregularly round, and the nerve root ran to the lateral side from the deformed foramen more than usual. A firm medial traction of the nerve root together with the psoas major muscle for the purpose of attaching a plate and inserting screws on the sacrum side could cause the temporary radiculopathy. For a 26-year-old woman with a thin sacral alar due to IIIb, SIJ arthrodesis using multi screws with the posterolateral approach was performed. The most cranial screw penetrated the anterior margin of the sacrum and caused nerve root injury. For a 35-year-old man with Ib, posterior SIJ arthrodesis was attempted using screws and cylinder cages. The insertion of the implants using the posterior approach was technically challenging due to the small size of the sacrum. Conclusions: Pre-surgical planning for SIJ arthrodesis, including a surgical approach, is particularly important when we see patients with sacral dysmorphism induced by each type of LSTV. The presented surgical pitfalls will be valuable when surgeons perform SIJ arthrodesis for patients with LSTV.
Reoperation Rates after Laminoplasty for Cervical Disorders: A 26-Year Period Survival Function Method Analysis.

Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa, Yasuhisa Tanaka, Takashi Kusakabe, Naoki Morozumi, Yutaka Koizumi, Tetsuro Sato, Hironori Hyodo, Tomowaki Nakagawa, Eiji Takahashi, Takeshi Hoshikawa, Hideki Imaizumi, Shinji Ogawa, Fumio Kasama, Haruo Kanno, Eiji Itoi, Shoichi Kokubun

Spine surgery and related research　3　(4)　304-311　2019

DOI： 10.22603/ssrr.2019-0028 　

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Introduction: Laminoplasty is a common surgery for cervical myelopathy. Previous studies have analyzed the reoperation rates in posterior decompression surgeries of the cervical spine. However, few studies have solely focused on midline-splitting laminoplasty (MSL) using a large number of patients. This aims to analyze the reoperation rates after MSL using the survival function method. Methods: Between 1988 and 2013, 4,208 MSLs were performed as a primary operation for cervical myelopathy and enrolled in our spinal surgery registration system. The Kaplan-Meier survival function method was used to analyze the rates of reoperation. Results: Of 4,208 patients with primary MSL, 40 underwent reoperation for neurological complications. The overall reoperation rate was 0.26%, 0.64%, 0.83%, 0.93%, and 0.95% at 1, 5, 10, 20, and >20 years, respectively. The causes of reoperation were postoperative cervical radiculopathy in 10 patients, stenosis at an adjacent level in 8, stenosis due to failed "open-door" lamina in 6, instability of the cervical spine in 4, cervical disc herniation in 3, elongation of ossification of the posterior longitudinal ligament in 3, spinal cord injury in 1, fracture of the cervical spine in 1, postoperative scar formation in 1, ossification of anterior longitudinal ligament in 1, and unknown in 2. The number of patients with surgical site infection (SSI) who needed surgical debridement was 34 (0.81%). Conclusions: Excluding reoperations for SSI, the reoperation rate of MSL was approximately 1.0% at the maximum of 26 years after surgery. MSL was determined to be a reliable surgical procedure regarding postoperative complications requiring additional surgeries.
Enhancing percutaneous pedicle screw fixation with hydroxyapatite granules: A biomechanical study using an osteoporotic bone model. International-journal Peer-reviewed

Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi

PloS one　14　(9)　e0223106　2019

DOI： 10.1371/journal.pone.0223106 　

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INTRODUCTION: Percutaneous pedicle screw (PPS) can provide internal fixation of the thoracolumbar spine through a minimally invasive surgical procedure. PPS fixation has been widely used to treat various spinal diseases. Rigid fixation of PPS is essential for managing osteoporotic spine in order to prevent the risks of screw loosening and implant failure. We recently developed a novel augmentation method using hydroxyapatite (HA) granules for PPS fixation. The aim of this study was to evaluate the strength and stiffness of PPS fixation augmented with HA granules using an osteoporotic bone model. METHODS: Screws were inserted into uniform synthetic bone (sawbones) with and without augmentation. The uniaxial pullout strength and insertion torque of the screws were evaluated. In addition, each screw underwent cyclic toggling under incrementally increasing physiological loads until 2 mm of screwhead displacement occurred. The maximal pullout strength (N), maximal insertion torque (N·cm), number of toggle cycles and maximal load (N) required to achieve 2-mm screwhead displacement were compared between the screws with and without augmentation. RESULTS: The maximal pullout strength was significantly stronger for screws with augmentation than for those without augmentation (302 ± 19 N vs. 254 ± 17 N, p < 0.05). In addition, the maximal insertion torque was significantly increased in screws with augmentation compared to those without augmentation (48 ± 4 N·cm vs. 26 ± 5 N·cm, p < 0.05). Furthermore, the number of toggle cycles and the maximal load required to reach 2 mm of displacement were significantly greater in screws with augmentation than in those without augmentation (106 ± 9 vs. 52 ± 10 cycles; 152 ± 4 N vs. 124 ± 5 N, p < 0.05). CONCLUSIONS: Augmentation using HA granules significantly enhanced the rigidity of PPS fixation in the osteoporotic bone model. The present study suggested that novel augmentation with HA granules may be a useful technique for PPS fixation in patients with osteoporotic spine.
Perioperative Complications After Surgery for Thoracic Ossification of Posterior Longitudinal Ligament: A Nationwide Multicenter Prospective Study. International-journal

Shiro Imagama, Kei Ando, Kazuhiro Takeuchi, Satoshi Kato, Hideki Murakami, Toshimi Aizawa, Hiroshi Ozawa, Tomohiko Hasegawa, Yukihiro Matsuyama, Masao Koda, Masashi Yamazaki, Hirotaka Chikuda, Shigeo Shindo, Yukihiro Nakagawa, Atsushi Kimura, Katsushi Takeshita, Kanichiro Wada, Hiroyuki Katoh, Masahiko Watanabe, Kei Yamada, Takeo Furuya, Takashi Tsuji, Shunsuke Fujibayashi, Kanji Mori, Yoshiharu Kawaguchi, Kota Watanabe, Morio Matsumoto, Toshitaka Yoshii, Atsushi Okawa

Spine　43　(23)　E1389-E1397　2018/12/01

DOI： 10.1097/BRS.0000000000002703 　

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STUDY DESIGN: Prospective, multicenter, nationwide study. OBJECTIVE: To investigate perioperative complications and risk factors in surgery for thoracic ossification of the posterior longitudinal ligament (T-OPLL) using data from the registry of the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. SUMMARY OF BACKGROUND DATA: There is no prospective multicenter study of surgical complications and risk factors for T-OPLL, and previous multicenter retrospective studies have lacked details. METHODS: Surgical methods, preoperative radiographic findings, pre- and postoperative thoracic myelopathy (Japanese Orthopaedic Association [JOA] score), prone and supine position test (PST), intraoperative ultrasonography, and intraoperative neurophysiological monitoring (IONM) were investigated prospectively in 115 cases (males: 55, females: 60, average age 53.1 y). Factors related to perioperative complications and risk factors for postoperative motor palsy were identified. RESULTS: Posterior decompression and fusion with instrumentation with or without dekyphosis was performed in 85 cases (74%). The JOA recovery rate at 1 year after surgery in all cases was 55%. Motor palsy occurred postoperatively in 37 cases (32.2%), with a mean recovery period of 2.7 months. A long recovery period for postoperative motor palsy was significantly associated with a high number of T-OPLL levels (P < 0.0001), lower preoperative JOA score (P < 0.05), and greater estimated blood loss (P < 0.05). Perioperative complications or postoperative motor palsy were significantly related to a higher number of T-OPLL levels, comorbid ossification of ligamentum flavum rate, lower preoperative JOA score, higher preoperative positive PST rate, more surgical invasiveness, a lower rate of intraoperative spinal cord floating in ultrasonography, and higher rate of deterioration of IONM. CONCLUSION: This study firstly demonstrated the perioperative complications with high postoperative motor palsy rate in a nationwide multicenter prospective study. Surgical outcomes for T-OPLL should be improved by identifying and preventing perioperative complications with significant risk factors. LEVEL OF EVIDENCE: 3.
Sacroiliac joint arthrodesis for chronic sacroiliac joint pain: an anterior approach and clinical outcomes with a minimum 5-year follow-up. International-journal Peer-reviewed

Eiichi Murakami, Daisuke Kurosawa, Toshimi Aizawa

Journal of neurosurgery. Spine　29　(3)　279-285　2018/09

DOI： 10.3171/2018.1.SPINE17115 　

ISSN： 1547-5654

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OBJECTIVE The authors evaluated the outcomes of sacroiliac joint (SIJ) arthrodesis via an original anterior approach to the upper anterior surface of the SIJ in patients with a minimum of 5 years' follow-up. METHODS The authors performed anterior SIJ arthrodesis in 45 patients between 2001 and 2015. Of these patients, 27 (11 men and 16 women; mean age at surgery 49 [24-86] years) were followed up for a minimum of 5 years (average 113 months, range 61-157 months). In the 14 patients in the earlier period of this study, the authors used an anterior approach to expose the SIJ by separating the iliac muscle from the iliac bone and performed internal fixation. In the 13 patients later in the study, the authors changed to a pararectal approach, which involved an incision along the lateral border of the rectus abdominal muscle. Then, extraperitoneally, the upper anterior surface of the SIJ was exposed between the psoas major muscle and the iliac muscle. RESULTS Among the 27 patients, 21 had unilateral anterior arthrodesis alone, 4 required additional posterior arthrodesis, and 2 required pelvic ring arthrodesis because of later pain on the opposite side. In the 21 patients with a unilateral anterior arthrodesis, outcome according to the modified Macnab criteria was excellent in 7, good in 11, and fair in 3. Outcomes were excellent, good, fair, and poor in 1 patient each among the 4 with additional posterior fusion. Outcomes were good and poor for 1 patient each among those with pelvic ring arthrodesis. All 27 patients demonstrated bone union of the SIJ on CT. Lateral femoral cutaneous neuralgia developed in 7 of the 27 patients; 6 patients had undergone the initial anterior method and 1 the later method. CONCLUSIONS Anterior SIJ arthrodesis was effective in most patients with severe SIJ pain resistant to conservative therapy. This approach has the advantage of direct curettage and bone graft into the wide area of the SIJ, which result in good bone union. In particular, the authors' current pararectal approach could decrease the potential risk of lateral cutaneous injury.
The effect of morphine added to periarticular multimodal drug injection or spinal anesthesia on pain management and functional recovery after total knee arthroplasty. Peer-reviewed

Seiya Miyamoto, Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Akira Sasaki, Ikuo Maeda, Masayuki Kamimura, Atsushi Takahashi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　23　(5)　801-806　2018/09

DOI： 10.1016/j.jos.2018.04.013 　

ISSN： 0949-2658

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BACKGROUND: The efficacy of morphine added to periarticular multimodal drug injection (PMDI) for pain management after total knee arthroplasty (TKA) is controversial. Adding morphine to spinal anesthesia has reportedly improved pain relief for the first 24 h. We examined the effect of morphine added to PMDI or spinal anesthesia on pain management and functional recovery after TKA. METHODS: A total of 97 patients were randomized into three groups: in Group A (34 patients), 10 mg morphine was added to PMDI; Group B (31 patients), 0.1 mg morphine was added to spinal anesthesia; and Group C (32 patients), morphine was added to neither the PMDI nor spinal anesthetic. To evaluate the efficacy of added morphine for pain management, we assessed rest pain, the number of times analgesics were used, and the time period until the first analgesic use. The adverse effects of morphine were assessed by counting the numbers of times vomiting occurred and antiemetics were used. Functional recovery was evaluated by recording the range of motion of the knee and the date of ability to walk. RESULTS: Rest pain was the least in Group B at 6 and 12 h after operation. The number of times analgesics were used was the least in Group B. The time period until the first analgesic use was the longest in Group B. The number of vomiting episodes was the least in Group C. The number of times antiemetics were used was higher in Group A than in Group C. There were no significant differences in the range of motion and date of ability to walk among the three groups. CONCLUSIONS: The efficacy of morphine added to PMDI was limited, and that of morphine added to spinal anesthesia disappeared within 20 h postoperatively. Adding morphine to PMDI or spinal anesthesia did not improve functional recovery and caused some adverse effects.
Spinal Cord Swelling After Surgery in Cervical Spondylotic Myelopathy: Relationship With Intramedullary Gd-DTPA Enhancement on MRI. International-journal Peer-reviewed

Hiroshi Ozawa, Toshimi Aizawa, Satoshi Tateda, Ko Hashimoto, Haruo Kanno, Masato Ishizuka

Clinical spine surgery　31　(7)　E363-E367-E367　2018/08

DOI： 10.1097/BSD.0000000000000664 　

ISSN： 2380-0186

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STUDY DESIGN: This is a prospective multicenter study. SUMMARY OF BACKGROUND DATA: Postoperative spinal cord swelling has been reported in patients with cervical spondylotic myelopathy. In the cases of the spinal cord swelling, the involvement in the intramedullary gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) enhancement on magnetic resonance imaging (MRI) was referred. OBJECTIVE: The prevalence and clinical relevance of postoperative spinal cord swelling and its relationship with intramedullary Gd-DTPA enhancement in patients with cervical spondylotic myelopathy were investigated. SUBJECTS AND METHODS: A total of 683 consecutive patients with cervical spondylotic myelopathy who underwent laminoplasty were examined. T1, T2, and Gd-DTPA-enhanced MRI were performed before surgery. Patients with intramedullary Gd-DTPA enhancement were allocated to the enhancement group. Fifty consecutive cases who did not exhibit intramedullary Gd-DTPA enhancement were allocated to the nonenhancement group. Both groups underwent MRI examinations at 1 month and 1 year after surgery. RESULTS: The prevalence of spinal cord swelling in the enhancement group (26%) was significantly higher than that in the nonenhancement group (4%) (P=0.0038). At 1 year after surgery, spinal cord swelling had resolved in all patients in the nonenhancement group, while it persisted in 3 of 13 patients (23%) in the enhancement group. On multiple regression analysis, intramedullary Gd-DTPA enhancement rather than the spinal cord swelling showed a significant influence in terms of recovery of the Japanese Orthopedic Association score. CONCLUSIONS: Surgical outcomes of patients with postoperative swelling should be evaluated separately according to the presence or absence of intramedullary Gd-DTPA enhancement on MRI. Spinal cord swelling associated with intramedullary Gd-DTPA enhancement was indicative of poor prognosis.
Recurrence of ossification of ligamentum flavum at the same intervertebral level in the thoracic spine: a report of two cases and review of the literature. International-journal Peer-reviewed

Haruo Kanno, Tadahisa Takahashi, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　27　(Suppl 3)　359-367　2018/07

DOI： 10.1007/s00586-017-5281-6 　

ISSN： 0940-6719

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PURPOSE: Ossification of the ligamentum flavum (OLF) is a possible cause of thoracic myelopathy. We report two rare cases with recurrent thoracic myelopathy caused by OLF markedly re-extended at the same intervertebral level after the primary surgery. METHODS: Both patients had thoracic myelopathy caused by OLF and underwent decompressive laminectomy and resection of the OLF in the primary surgery. However, the neurological conditions gradually deteriorated following recovery after the primary surgery due to the recurrent OLF at the same intervertebral level. RESULTS: These patients were successfully treated by revision surgery via resection of the recurrent OLF and posterior spinal fusion with instrumentation. Two years after the second surgery, the neurological disturbance was resolved satisfactorily, and re-growth of the resected ossified lesion was not observed. CONCLUSIONS: The recurrence of OLF following resection of the ossified lesions is exceedingly rare but should be noted in patients treated surgically for thoracic myelopathy due to OLF.
Recurrent primary osseous hemangiopericytoma in the thoracic spine: a case report and literature review. International-journal Peer-reviewed

Takahiro Onoki, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　27　(Suppl 3)　386-392　2018/07

DOI： 10.1007/s00586-017-5322-1 　

ISSN： 0940-6719

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PURPOSE: Primary osseous hemangiopericytoma (HPC) of the spine is exceedingly rare. HPC has malignant potential and has the capacity for metastasis and local recurrence. We herein present the first case of recurrent primary osseous HPC in the thoracic spine that was successfully treated by total spondylectomy at three vertebral levels and spinal reconstruction. METHODS: We performed a two-stage operation for recurrent HPC using anterior and posterior approaches at the T5-T7 vertebrae. The preoperative embolization of the tumor was performed to prevent massive intraoperative bleeding. Then, total spondylectomy was performed (T5-T7) to resect the tumor. Anterior spinal reconstruction and posterior instrumentation were performed, with abundant bone autograft and allograft used to achieve sufficient boney fusion following the removal of the tumor. RESULTS: At 2 years after surgery, the patient had made a sufficient recovery from his symptoms. The bone union was complete without tumor recurrence or implant failure. CONCLUSIONS: Total spondylectomy and spinal reconstruction with instrumentation might be useful for performing the safe and adequate excision of recurrent HPC of the spine. However, patients should be closely monitored to detect local recurrence and the malignant degeneration of the tumor after surgery.
再発した硬膜内髄外血管腫の2例

半田恭一, 相澤俊峰, 橋本功, 菅野晴夫, 山屋誠司, 松田倫治, 衛藤俊光, 小澤浩司

東北整形災害外科学会雑誌　61　(1)　234-234　2018/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Study protocol for the G-SPIRIT trial: a randomised, placebo-controlled, double-blinded phase III trial of granulocyte colony-stimulating factor-mediated neuroprotection for acute spinal cord injury. International-journal

Masao Koda, Hideki Hanaoka, Takatoshi Sato, Yasuhisa Fujii, Michiko Hanawa, Sho Takahashi, Takeo Furuya, Yasushi Ijima, Junya Saito, Mitsuhiro Kitamura, Seiji Ohtori, Yukei Matsumoto, Tetsuya Abe, Kei Watanabe, Toru Hirano, Masayuki Ohashi, Hirokazu Shoji, Tatsuki Mizouchi, Ikuko Takahashi, Norio Kawahara, Masahito Kawaguchi, Yugo Orita, Takeshi Sasamoto, Masahito Yoshioka, Masafumi Fujii, Katsutaka Yonezawa, Daisuke Soma, Hiroshi Taneichi, Daisaku Takeuchi, Satoshi Inami, Hiroshi Moridaira, Haruki Ueda, Futoshi Asano, Yosuke Shibao, Ikuo Aita, Yosuke Takeuchi, Masaya Mimura, Jun Shimbo, Yukio Someya, Sumio Ikenoue, Hiroaki Sameda, Kan Takase, Yoshikazu Ikeda, Fumitake Nakajima, Mitsuhiro Hashimoto, Tomoyuki Ozawa, Fumio Hasue, Takayuki Fujiyoshi, Koshiro Kamiya, Masahiko Watanabe, Hiroyuki Katoh, Yukihiro Matsuyama, Yu Yamamoto, Daisuke Togawa, Tomohiko Hasegawa, Sho Kobayashi, Go Yoshida, Shin Oe, Tomohiro Banno, Hideyuki Arima, Koji Akeda, Eiji Kawamoto, Hiroshi Imai, Toshihiko Sakakibara, Akihiro Sudo, Yasuo Ito, Tsuyoshi Kikuchi, Shuhei Osaki, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Shinji Kotaka, Hideo Baba, Tsuyoshi Okudaira, Hiroaki Konishi, Takayuki Yamaguchi, Keigo Ito, Yoshito Katayama, Taro Matsumoto, Tomohiro Matsumoto, Masaru Idota, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Toshimitsu Eto, Takehiro Sugaya, Michiharu Matsuda, Kazunari Fushimi, Satoshi Nozawa, Chizuo Iwai, Toshihiko Taguchi, Tsukasa Kanchiku, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Masashi Yamazaki

BMJ open　8　(5)　e019083　2018/05/05

DOI： 10.1136/bmjopen-2017-019083 　

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INTRODUCTION: Granulocyte colony-stimulating factor (G-CSF) is generally used for neutropaenia. Previous experimental studies revealed that G-CSF promoted neurological recovery after spinal cord injury (SCI). Next, we moved to early phase of clinical trials. In a phase I/IIa trial, no adverse events were observed. Next, we conducted a non-randomised, non-blinded, comparative trial, which suggested the efficacy of G-CSF for promoting neurological recovery. Based on those results, we are now performing a phase III trial. METHODS AND ANALYSIS: The objective of this study is to evaluate the efficacy of G-CSF for acute SCI. The study design is a prospective, multicentre, randomised, double-blinded, placebo-controlled comparative study. The current trial includes cervical SCI (severity of American Spinal Injury Association (ASIA) Impairment Scale B/C) within 48 hours after injury. Patients are randomly assigned to G-CSF and placebo groups. The G-CSF group is administered 400 µg/m2/day×5 days of G-CSF in normal saline via intravenous infusion for 5 consecutive days. The placebo group is similarly administered a placebo. Our primary endpoint is changes in ASIA motor scores from baseline to 3 months. Each group includes 44 patients (88 total patients). ETHICS AND DISSEMINATION: The study will be conducted according to the principles of the World Medical Association Declaration of Helsinki and in accordance with the Japanese Medical Research Involving Human Subjects Act and other guidelines, regulations and Acts. Results of the clinical study will be submitted to the head of the respective clinical study site as a report after conclusion of the clinical study by the sponsor-investigator. Even if the results are not favourable despite conducting the clinical study properly, the data will be published as a paper. TRIAL REGISTRATION NUMBER: UMIN000018752.
An increase in the degree of olisthesis during axial loading reduces the dural sac size and worsens clinical symptoms in patients with degenerative spondylolisthesis. International-journal Peer-reviewed

Haruo Kanno, Toshimi Aizawa, Hiroshi Ozawa, Yutaka Koizumi, Naoki Morozumi, Eiji Itoi

The spine journal : official journal of the North American Spine Society　18　(5)　726-733　2018/05

DOI： 10.1016/j.spinee.2017.08.251 　

ISSN： 1529-9430

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BACKGROUND CONTEXT: Previous studies have shown that axial loading during magnetic resonance imaging (MRI) significantly reduces the size of the dural sac compared with conventional MRI in patients with degenerative lumbar disease. In our previous study, axial-loaded MRI showed a significantly larger degree of olisthesis than conventional MRI in patients with degenerative spondylolisthesis (DS). Furthermore, the degree of olisthesis on axial-loaded MRI correlated more strongly with that observed on X-ray in the upright position. However, no study has investigated whether or not the increase in the degree of olisthesis during axial loading correlates with the reduction in the dural sac size and affects the severity of clinical symptoms in patients with DS. PURPOSE: The objective of this study was to determine whether or not the increase in the degree of olisthesis correlates with the reduction of the dural sac cross-sectional area (DCSA) detected on axial-loaded MRI and worsens the severity of clinical symptoms in patients with DS. STUDY DESIGN/SETTING: This is an imaging cohort study. PATIENT SAMPLE: A total of 41 consecutive patients with DS were prospectively evaluated in this study. OUTCOME MEASURES: The outcome measures include the degree of olisthesis, the DCSA, the Pearson correlation coefficient, and the severity of clinical symptoms. MATERIALS AND METHODS: The differences in the degree of olisthesis and the DCSA between conventional and axial-loaded MRIs were determined. The Pearson correlation coefficient of the increase in the degree of olisthesis with the reduction in the DCSA during axial loading was calculated. The reduction in the DCSA and the severity of clinical symptoms in patients exhibiting a ≥2-mm increase in the degree of olisthesis were compared with those in patients exhibiting a <2-mm increase. RESULTS: The increase in the degree of olisthesis was significantly correlated with the reduction in the DCSA during axial loading (Pearson correlation coefficient=0.63, p<.001). The reduction in the DCSA during axial loading in patients with a ≥2-mm increase in the degree of olisthesis (26±3 mm2) was significantly greater than in those with a <2-mm increase (13±2 mm2) (p<.01). Clinical symptoms such as walking distance and activity of daily living evaluated using the Japanese Orthopaedic Association score were significantly worse in patients with a ≥2-mm increase in the degree of olisthesis (117±19 m and 6.7±0.5 points, respectively) than in those with a <2-mm increase (236±36 m and 8.4±0.4 points, respectively) (p<.05). CONCLUSIONS: The present study demonstrated that the increase in the degree of olisthesis was significantly correlated with the reduction in the dural sac size detected on axial-loaded MRI and worsened the severity of clinical symptoms in patients with DS. These results suggest that axial-loaded MRI may be a useful imaging study for detecting dynamic changes in the degree of olisthesis during axial loading to the lumbar spine related to the narrowing of the spinal canal and the severity of clinical symptoms in the assessment of patients with DS.
HA顆粒による経皮的椎弓根スクリューの新たな補強法の検討生体力学的解析による骨粗鬆症脊椎への有効性の解析

菅野晴夫, 相澤俊峰, 橋本功, 山屋誠司, 井樋栄二

日本整形外科学会雑誌　92　(2)　S43-S43　2018/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
仙椎部巨大神経鞘腫の治療成績

半田恭一, 小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 舘田聡, 井樋栄二

日本整形外科学会雑誌　92　(3)　S791-S791　2018/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
腰椎MRIのnerve root sedimentation signとredundant nerve rootの有無による脊柱管狭窄・臨床症状の比較

菅野晴夫, 相澤俊峰, 橋本功, 山屋誠司, 井樋栄二

日本整形外科学会雑誌　92　(3)　S1069-S1069　2018/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
3D fusion imagingを応用した頸椎内視鏡下後方除圧術の3次元手術シミュレーションの有用性と課題

山屋誠司, 野村和教, 中村陽介, 中尾慎一, 中尾裕次, 綿貫匡則, 綿貫昭則, 菅野晴夫, 橋本功, 相澤俊峰, 井樋栄二, 山田宏, 吉田宗人

Journal of Spine Research　9　(3)　236-236　2018/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
HA顆粒を用いた経皮的椎弓根スクリュー固定の補強法骨粗鬆症脊椎への有効性の生体力学的解析

菅野晴夫, 相澤俊峰, 橋本功, 山屋誠司, 井樋栄二

Journal of Spine Research　9　(3)　383-383　2018/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
片側椎弓切除による脊髄腫瘍摘出術の検証脊髄腫瘍約900手術症例の解析

橋本功, 相澤俊峰, 菅野晴夫, 山屋誠司, 小澤浩司, 国分正一

Journal of Spine Research　9　(3)　554-554　2018/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
腰椎MRIにおけるnerve root sedimentation signとredundant nerve rootの検討脊柱管狭窄・臨床症状との関連

菅野晴夫, 相澤俊峰, 橋本功, 山屋誠司, 井樋栄二

Journal of Spine Research　9　(3)　577-577　2018/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
超高齢化に伴う脊椎外科手術数の変化

相澤俊峰, 田中靖久, 日下部隆, 橋本功, 菅野晴夫, 両角直樹, 古泉豊, 小川真司, 星川健, 兵藤弘訓, 村上栄一, 笠間忠夫, 佐藤哲朗, 小澤浩司, 国分正一

Journal of Spine Research　9　(2)　125-130　2018/02
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
Treatment strategy for sacroiliac joint-related pain at or around the posterior superior iliac spine. International-journal Peer-reviewed

Eiichi Murakami, Daisuke Kurosawa, Toshimi Aizawa

Clinical neurology and neurosurgery　165　43-46　2018/02
Publisher: Elsevier B.V.
DOI： 10.1016/j.clineuro.2017.12.017 　

ISSN： 1872-6968 0303-8467
Diagnosis of benign notochordal cell tumor of the spine: is a biopsy necessary? International-journal

Satoshi Tateda, Ko Hashimoto, Toshimi Aizawa, Haruo Kanno, Shin Hitachi, Eiji Itoi, Hiroshi Ozawa

Clinical case reports　6　(1)　63-67　2018/01

DOI： 10.1002/ccr3.1287 　

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Benign notochordal cell tumor is a benign intraosseous lesion, demonstrates characteristic imaging features. The lesion demonstrates low-signal intensity in T1-weighted images, high-signal intensity in T2-weighted images, and no enhancement with contrast medium in MRI and slight osteosclerosis in CT. If typical imaging findings are identified, biopsy is not necessary.
Femoral footprint of the popliteus tendon may be at the risk of damage during total knee arthroplasty. International-journal Peer-reviewed

Takashi Aki, Takehiko Sugita, Atsushi Takahashi, Toshimi Aizawa, Masayuki Kamimura, Akira Sasaki, Naohisa Miyatake, Eiji Itoi

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA　25　(12)　3718-3722　2017/12

DOI： 10.1007/s00167-016-4177-z 　

ISSN： 0942-2056

eISSN： 1433-7347
Groin pain associated with sacroiliac joint dysfunction and lumbar disorders. International-journal Peer-reviewed

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa

Clinical neurology and neurosurgery　161　104-109　2017/10
Publisher: Elsevier B.V.
DOI： 10.1016/j.clineuro.2017.08.018 　

ISSN： 1872-6968 0303-8467
HA顆粒を用いた経皮的椎弓根スクリュー固定に対する新たなaugmentation法生体力学的解析による骨粗鬆症脊椎への有効性の解析

菅野晴夫, 相澤俊峰, 橋本功, 井樋栄二

日本整形外科学会雑誌　91　(8)　S1638-S1638　2017/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Body Mass Index 35kg/m2以上の患者の脊椎手術における問題点

八幡健一郎, 相澤俊峰, 橋本功, 菅野晴夫, 舘田聡, 井樋栄二, 小澤浩司

東北整形災害外科学会雑誌　60　(1)　191-191　2017/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
同一椎間に再発した胸椎黄色靱帯骨化症の2例

高橋忠久, 菅野晴夫, 相澤俊峰, 橋本功, 井樋栄二, 小澤浩司

東北整形災害外科学会雑誌　60　(1)　101-105　2017/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Leg symptoms associated with sacroiliac joint disorder and related pain. International-journal Peer-reviewed

Eiichi Murakami, Toshimi Aizawa, Daisuke Kurosawa, Kyoko Noguchi

Clinical neurology and neurosurgery　157　55-58　2017/06
Publisher: Elsevier B.V.
DOI： 10.1016/j.clineuro.2017.03.020 　

ISSN： 1872-6968 0303-8467
Preliminary results of managing large medial tibial defects in primary total knee arthroplasty: autogenous morcellised bone graft. International-journal Peer-reviewed

Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Akira Sasaki, Masayuki Kamimura, Atsushi Takahashi

International orthopaedics　41　(5)　931-937　2017/05

DOI： 10.1007/s00264-016-3339-4 　

ISSN： 0341-2695

eISSN： 1432-5195
Successful Management of Gorham-Stout Disease in the Cervical Spine by Combined Conservative and Surgical Treatments: A Case Report. Peer-reviewed

Satoshi Tateda, Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Susumu Ohtsu, Eiji Itoi, Hiroshi Ozawa

The Tohoku journal of experimental medicine　241　(4)　249-254　2017/04

DOI： 10.1620/tjem.241.249 　

ISSN： 0040-8727

eISSN： 1349-3329
脊椎手術後の遠隔脳出血発生頻度の前向き研究

相澤俊峰, 小澤浩司, 橋本功, 菅野晴夫, 井樋栄二

日本整形外科学会雑誌　91　(2)　S40-S40　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
片側椎弓切除による脊髄腫瘍摘出術の検証

橋本功, 相澤俊峰, 菅野晴夫, 小澤浩司, 国分正一

日本整形外科学会雑誌　91　(3)　S662-S662　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
腰部脊柱管狭窄症におけるnerve root sedimentation signと臨床症状の重症度の関連

菅野晴夫, 相澤俊峰, 橋本功, 井樋栄二

日本整形外科学会雑誌　91　(3)　S742-S742　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
腰椎椎間孔内・外狭窄病変に対して3D fusion imagingを用いた内視鏡下手術シミュレーションの有用性

山屋誠司, 菅野晴夫, 中村聡, 高橋伸光, 橋本功, 相澤俊峰, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　91　(3)　S829-S829　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
経皮的椎弓根スクリュー固定に対するHA顆粒を用いた新たなaugmentation法

菅野晴夫, 相澤俊峰, 橋本功, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　91　(3)　S837-S837　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
小児脊髄腫瘍に対する片側椎弓切除による腫瘍摘出後脊柱変形

松田倫治, 相澤俊峰, 橋本功, 菅野晴夫, 衛藤俊光, 井樋栄二

Journal of Spine Research　8　(3)　366-366　2017/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
経皮的内視鏡下椎間板摘出術に対する3D fusion imagingを用いた新しい3次元術前計画 exiting nerve injuryを防ぐためのシミュレーション手術

山屋誠司, 菅野晴夫, 中村聡, 高橋伸光, 橋本功, 相澤俊峰, 井樋栄二

Journal of Spine Research　8　(3)　491-491　2017/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
超高齢社会に伴う脊椎疾患の手術数の変化

相澤俊峰, 国分正一, 橋本功, 菅野晴夫, 小澤浩司, 田中靖久, 日下部隆, 両角直樹, 古泉豊, 井樋栄二

Journal of Spine Research　8　(3)　749-749　2017/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
腰部脊柱管狭窄症におけるnerve root sedimentation sign 脊柱管狭窄の程度・臨床症状の重症度との関連

菅野晴夫, 相澤俊峰, 橋本功, 衛藤俊光, 井樋栄二, 小澤浩司

Journal of Spine Research　8　(3)　759-759　2017/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
高齢者脊椎手術(80歳以上)の疫学東北大学脊椎外科懇話会・27年間の脊椎手術登録から

橋本功, 相澤俊峰, 菅野晴夫, 佐藤哲朗, 田中靖久, 両角直樹, 古泉豊, 日下部隆, 小澤浩司, 兵藤弘訓, 井樋栄二, 国分正一

Journal of Spine Research　8　(3)　775-775　2017/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
術後創傷感染症と手術侵襲による炎症反応はどう違うのかダメージ関連分子パターンに着目した検討 Peer-reviewed

小圷知明, 山田充啓, 相澤俊峰, 橋本功, 井樋栄二, 久志本成樹

日本整形外科学会雑誌　91　(2)　S77-S77　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊椎外科周術期におけるダメージ関連分子パターンの動態術後創傷感染症と手術侵襲による炎症反応はどう違うのか? Peer-reviewed

小圷知明, 山田充啓, 相澤俊峰, 橋本功, 井樋栄二, 久志本成樹

Journal of Spine Research　8　(3)　560-560　2017/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
Evaluation of the size and position of the insertion of the anterior medial meniscus root in varus osteoarthritic knees. International-journal Peer-reviewed

Akira Sasaki, Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Masayuki Kamimura, Hirokazu Fujisawa, Atsushi Takahashi

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA　25　(2)　362-367　2017/02

DOI： 10.1007/s00167-015-3963-3 　

ISSN： 0942-2056

eISSN： 1433-7347
Comparison of intraoperative anthropometric measurements of the proximal tibia and tibial component in total knee arthroplasty. Peer-reviewed

Naohisa Miyatake, Takehiko Sugita, Toshimi Aizawa, Akira Sasaki, Ikuo Maeda, Masayuki Kamimura, Hirokazu Fujisawa, Atsushi Takahashi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　21　(5)　635-9　2016/09

DOI： 10.1016/j.jos.2016.06.003 　

ISSN： 0949-2658

eISSN： 1436-2023
New diagnostic support tool for patients with leg symptoms caused by lumbar spinal stenosis and lumbar intervertebral disc herniation: A self-administered, self-reported history questionnaire.

Toshimi Aizawa, Yasuhisa Tanaka, Toru Yokoyama, Yoichi Shimada, Ken Yamazaki, Hiroshi Takei, Shin-Ichi Konno, Chikashi Kawahara, Eiji Itoi, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　21　(5)　579-85　2016/09

DOI： 10.1016/j.jos.2016.07.012 　

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BACKGROUND: There are no diagnostic support tools composed of a simple, single-sheet, self-administered, self-reported history questionnaire (SSHQ) for patients with leg symptoms caused by either lumbar spinal stenosis (LSS) or lumbar disc herniation (LDH), at the same time, can discriminate the two diseases. METHODS: We conducted retrospective and prospective derivation studies and a prospective validation study. Based on data from 137 patients with LSS and 206 with LDH, we identified key prediction factors to establish the diagnosis of LSS and LDH, which became the basis of a temporary SSHQ. Next, we performed a prospective derivation study in which 296 patients with LSS or LDH completed preoperatively this temporary SSHQ. After univariate and multivariate analyses of each question, questions on both diseases in addition to age factor were selected, providing the final version of the SSHQ. A validation study was subsequently performed with 342 consecutive patients with leg symptoms. The sensitivity, specificity and likelihood ratio of this SSHQ were calculated to determine the cut-off points for LSS and LDH. RESULTS: A SSHQ with 15 questions was developed from retrospective and prospective derivation studies. The score of each question was weighted based on the multivariate analysis and then, it was approximated to integer value. According to assessment of the discriminatory performance of the clinical prediction rule of the SSHQ, the cut-off point for LSS was ≥13 and that for LDH was ≥11. The sensitivity, specificity, and positive and negative likelihood ratios of this SSHQ at those cut-off points were, respectively, 92.7%, 84.7%, 6.07, and 0.09 for LSS, and 91.0%, 85.2%, 6.15, and 0.11 for LDH. CONCLUSIONS: This is the first report of a diagnostic support tool for patients with LSS- or LDH-induced leg symptoms combined in a single SSHQ that could help establish diagnosis of the two diseases in the daily clinical practice.
治療に成功した頸椎Gorham病の一例

舘田聡, 相澤俊峰, 橋本功, 菅野晴夫, 井樋栄二, 小澤浩司

東日本整形災害外科学会雑誌　28　(3)　401-401　2016/08
Publisher: 東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
骨粗鬆症脊椎に対する経皮的椎弓根スクリューの固定性の生体力学的研究 HA顆粒を用いた新たなaugmentation法の開発と有効性の検討

菅野晴夫, 相澤俊峰, 橋本功, 衛藤俊光, 井樋栄二

日本整形外科学会雑誌　90　(8)　S1710-S1710　2016/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
当院におけるBenign notochordal cell tumorの経験

舘田聡, 相澤俊峰, 小澤浩司, 橋本功, 菅野晴夫, 八幡健一郎, 常陸真

東北整形災害外科学会雑誌　59　(1)　235-235　2016/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
良性脊索細胞腫(benign notochordal cell tumor)の臨床的画像的特徴

舘田聡, 小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 八幡健一郎, 井樋栄二, 常陸真

日本整形外科学会雑誌　90　(6)　S1397-S1397　2016/06
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Comparative study of treatment for distal radius fractures with two different palmar locking plates. Peer-reviewed

Tanaka H, Hatta T, Sasajima K, Itoi E, Aizawa T

The Journal of hand surgery, European volume　41　(5)　536-542　2016/06

DOI： 10.1177/1753193415625830 　

ISSN： 1753-1934
腰部脊柱管狭窄症の保存療法 2年以上手術しなかった症例の検討 Peer-reviewed

相澤俊峰, 小澤, 浩司, 日下部, 隆, 橋本功, 菅野, 晴夫, 両角, 直樹, 古泉, 豊, 佐藤, 哲朗, 兵藤, 弘訓, 小川, 真司, 笠間, 史夫, 星川, 健, 国分, 正一, 舘田, 聡八幡, 健一郎, 谷, 正太郎, 井樋栄二

東北整形災害外科学会雑誌　59　(1)　20-23　2016/06
Publisher:
ISSN： 1348-8694
Increased facet fluid predicts dynamic changes in the dural sac size on Axial-loaded MRi in patients with lumbar spinal canal stenosis Peer-reviewed

H. Kanno, H. Ozawa, Y. Koizumi, N. Morozumi, T. Aizawa, E. Itoi

American Journal of Neuroradiology　37　(4)　730-735　2016/04/01
Publisher: American Society of Neuroradiology
DOI： 10.3174/ajnr.A4582 　

ISSN： 1936-959X 0195-6108
脊椎外科周術期におけるプレセプシンの動態―術後創傷感染症早期診断における有用性―

小圷知明, 佐藤哲哉, 桑原功行, 工藤大介, 相澤俊峰, 橋本功, 井樋栄二, 久志本成樹

Journal of Spine Research　7　(3)　409　2016/03/25

ISSN： 1884-7137
腰部脊柱管狭窄症におけるnerve root sedimentation signと臨床症状の関係

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

日本整形外科学会雑誌　90　(2)　S201-S201　2016/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
腰部脊柱管狭窄症におけるnerve root sedimentation signと臨床症状の関係

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

Journal of Spine Research　7　(3)　550-550　2016/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
脊椎手術後の遠隔小脳出血後ろ向き研究と前向き研究

相澤俊峰, 芦名善博, 橋本功, 菅野晴夫, 井樋栄二, 小澤浩司

Journal of Spine Research　7　(3)　581-581　2016/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
頸椎前方除圧固定術と椎弓形成術の再手術率生存分析を用いた最長26年間の検討

橋本功, 小澤浩司, 相澤俊峰, 菅野晴夫, 舘田聡, 八幡健一郎, 井樋栄二, 国分正一

Journal of Spine Research　7　(3)　730-730　2016/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
Increasing Incidence of Degenerative Spinal Diseases in Japan during 25 Years: The Registration System of Spinal Surgery in Tohoku University Spine Society. Peer-reviewed

Toshimi Aizawa, Shoichi Kokubun, Hiroshi Ozawa, Takashi Kusakabe, Yasuhisa Tanaka, Takeshi Hoshikawa, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yutaka Koizumi, Tetsuro Sato, Hironori Hyodo, Fumio Kasama, Shinji Ogawa, Eiichi Murakami, Chikashi Kawahara, Jun-Ichiro Yahata, Yushin Ishii, Eiji Itoi

The Tohoku journal of experimental medicine　238　(2)　153-63　2016/02

DOI： 10.1620/tjem.238.153 　

ISSN： 0040-8727

eISSN： 1349-3329
Potential risk of excising the femoral insertion of the popliteus tendon during primary total knee arthroplasty: a biometric study. Peer-reviewed

Atsushi Takahashi, Takehiko Sugita, Toshimi Aizawa, Daisuke Chiba, Masayuki Kamimura, Takashi Aki, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　20　(6)　1030-5　2015/11

DOI： 10.1007/s00776-015-0773-x 　

ISSN： 0949-2658

eISSN： 1436-2023
高齢者の転倒と認知機能障害大腿骨近位部骨折患者の予備的検討

葛西真理, 目黒謙一, 小澤浩司, 相澤俊峰, 熊居慶一, 今泉秀樹, 大泉晶, 峯岸英絵, 山口智, 井樋栄二

Dementia Japan　29　(3)　410-410　2015/09
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
Autologous morselised bone grafting for medial tibial defects in total knee arthroplasty. International-journal Peer-reviewed

Takehiko Sugita, Toshimi Aizawa, Akira Sasaki, Naohisa Miyatake, Hirokazu Fujisawa, Masayuki Kamimura

Journal of orthopaedic surgery (Hong Kong)　23　(2)　185-9　2015/08

DOI： 10.1177/230949901502300214 　

ISSN： 1022-5536

eISSN： 2309-4990
Tumor-induced osteomalacia caused by phosphaturic mesenchymal tumor of the cervical spine. Peer-reviewed

Takeshi Nakamura, Toshimi Aizawa, Takeshi Hoshikawa, Hiroshi Ozawa, Nobuaki Ito, Seiji Fukumoto, Eiji Itoi, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　20　(4)　765-71　2015/07

DOI： 10.1007/s00776-014-0540-4 　

ISSN： 0949-2658
緊急手術を要した胸椎から仙骨にわたる広範囲の術後胸腰椎硬膜下膿瘍の1例

八幡健一郎, 小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 舘田聡, 井樋栄二, 高橋良正, 佐藤哲朗

東北整形災害外科学会雑誌　58　(1)　196-196　2015/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Changes in lumbar spondylolisthesis on axial-loaded MRI: do they reproduce the positional changes in the degree of olisthesis observed on X-ray images in the standing position? International-journal Peer-reviewed

Haruo Kanno, Hiroshi Ozawa, Yutaka Koizumi, Naoki Morozumi, Toshimi Aizawa, Yushin Ishii, Eiji Itoi

The spine journal : official journal of the North American Spine Society　15　(6)　1255-62　2015/06/01

DOI： 10.1016/j.spinee.2015.02.016 　

ISSN： 1529-9430

eISSN： 1878-1632
頸髄症におけるMRI髄内T2高輝度領域のパターンと病理像の関係について

小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 井樋栄二

日本整形外科学会雑誌　89　(2)　S107-S107　2015/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
荷重MRIによる腰椎変性すべりの動的変化の検討荷重によるすべりの増大と臨床症状の関係

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

Journal of Spine Research　6　(3)　553-553　2015/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
荷重MRIにおける腰部脊柱管狭窄の検討荷重による動的狭窄のリスク因子の解析

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

日本整形外科学会雑誌　89　(3)　S638-S638　2015/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Referred pain location depends on the affected section of the sacroiliac joint. International-journal Peer-reviewed

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　24　(3)　521-7　2015/03
Publisher: Springer Verlag
DOI： 10.1007/s00586-014-3604-4 　

ISSN： 1432-0932 0940-6719
胸椎砂時計腫の手術成績脊椎固定は必要か? Peer-reviewed

相澤俊峰, 小澤, 浩司, 橋本, 功, 菅野, 晴夫, 舘田, 聡, 矢部, 裕, 八幡, 健一郎, 井樋栄二

Journal of Spine Research　6　(3)　528-528　2015/03
Publisher:
ISSN： 1884-7137

eISSN： 2435-1563
腰椎2大疾患の再手術率脊柱管狭窄症と椎間板ヘルニア再手術率の生存分析 Peer-reviewed

相澤俊峰, 小澤, 浩司, 橋本, 功, 菅野, 晴夫, 日下部, 隆, 関口, 玲, 佐藤, 哲朗, 高橋, 永次, 両角, 直樹, 国分, 正一, 井樋栄二

日本整形外科学会雑誌　89　(2)　S61-S61　2015/03
Reoperation rates after fenestration for lumbar spinal canal stenosis: a 20-year period survival function method analysis. International-journal Peer-reviewed

Toshimi Aizawa, Hiroshi Ozawa, Takashi Kusakabe, Yasuhisa Tanaka, Akira Sekiguchi, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yushin Ishii, Tetsuro Sato, Eiji Takahashi, Shoichi Kokubun, Eiji Itoi

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　24　(2)　381-7　2015/02
Publisher: Maik Nauka-Interperiodica Publishing
DOI： 10.1007/s00586-014-3479-4 　

ISSN： 1555-6174 0031-0301
Reoperation rates after fenestration for lumbar spinal canal stenosis: a 20-year period survival function method analysis Peer-reviewed

Toshimi Aizawa, Hiroshi Ozawa, Takashi Kusakabe, Yasuhisa Tanaka, Akira Sekiguchi, Ko Hashimoto, Haruo Kanno, Naoki Morozumi, Yushin Ishii, Tetsuro Sato, Eiji Takahashi, Shoichi Kokubun, Eiji Itoi

EUROPEAN SPINE JOURNAL　24　(2)　381-387　2015/02

DOI： 10.1007/s00586-014-3479-4 　

ISSN： 0940-6719

eISSN： 1432-0932
Quality of life after bilateral total knee arthroplasty determined by a 3-year longitudinal evaluation using the Japanese knee osteoarthritis measure. Peer-reviewed

Takehiko Sugita, Yasuhiro Kikuchi, Toshimi Aizawa, Akira Sasaki, Naohisa Miyatake, Ikuo Maeda

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　20　(1)　137-42　2015/01

DOI： 10.1007/s00776-014-0645-9 　

ISSN： 0949-2658

eISSN： 1436-2023
Medial meniscus tear morphology and related clinical symptoms in patients with medial knee osteoarthritis. International-journal Peer-reviewed

Masayuki Kamimura, Jutaro Umehara, Atsushi Takahashi, Toshimi Aizawa, Eiji Itoi

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA　23　(1)　158-63　2015/01

DOI： 10.1007/s00167-014-2939-z 　

ISSN： 0942-2056

eISSN： 1433-7347
硬膜内髄外腫瘍との鑑別が問題となるidiopathic hypertrophic pachymeningitisの1例

品川清嗣, 小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 園淵和明, 井樋栄二

東日本整形災害外科学会雑誌　26　(3)　408-408　2014/08
Publisher: 東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
脊柱後彎症に対する新しい股装具の開発

小澤浩司, 相澤俊峰, 橋本功, 菅野晴夫, 井樋栄二

運動器リハビリテーション　25　(2)　187-187　2014/06
Publisher: 日本運動器科学会
ISSN： 2187-8420
腰椎変性すべり症に対する開窓術の限界同一椎間再手術例の検討

相澤俊峰, 小澤浩司, 橋本功, 菅野晴夫, 両角直樹, 日下部隆, 川原央, 高橋永次, 佐藤哲朗, 国分正一, 井樋栄二

日本整形外科学会雑誌　88　(2)　S181-S181　2014/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
荷重MRIによる腰部脊柱管狭窄の画像診断立位の脊髄造影像における狭窄椎間の同定

菅野晴夫, 小澤浩司, 相澤俊峰, 古泉豊, 両角直樹, 橋本功, 石井祐信, 井樋栄二

日本整形外科学会雑誌　88　(2)　S202-S202　2014/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
頸髄症における術後脊髄腫脹の出現と画像の特徴について

小澤浩司, 佐藤哲朗, 相澤俊峰, 菅野晴夫, 橋本功, 井樋栄二, 国分正一

日本整形外科学会雑誌　88　(3)　S976-S976　2014/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
荷重MRIによる腰部脊柱管狭窄症の画像診断脊髄造影像における狭窄をどこまで捉えるか

菅野晴夫, 小澤浩司, 相澤俊峰, 橋本功, 井樋栄二

Journal of Spine Research　5　(3)　436-436　2014/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
Atypical findings on magnetic resonance imaging in the patients with active pyogenic spondylitis in Japanese university hospitals. Peer-reviewed

Toshimi Aizawa, Hiroshi Ozawa, Tomoaki Koakutsu, Takeshi Nakamura, Haruo Kanno, Toru Hirano, Atsuki Sano, Takui Ito, Eiji Itoi

The Tohoku journal of experimental medicine　231　(1)　13-9　2013/09

DOI： 10.1620/tjem.231.13 　

ISSN： 0040-8727

eISSN： 1349-3329
Bone formation within the articular cartilage of the lateral compartment of varus osteoarthritic knees. Peer-reviewed

Takehiko Sugita, Toshimi Aizawa, Tomomaro Kawamata, Akira Sasaki, Mitsuhiro Kashiwaba, Atsushi Takahashi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　18　(4)　543-6　2013/07

DOI： 10.1007/s00776-013-0396-z 　

ISSN： 0949-2658
Effect of medial tibial torsion on the sagittal alignment of lower legs in patients with medial knee osteoarthritis. International-journal Peer-reviewed

Atsushi Takahashi, Toshimi Aizawa, Takashi Aki, Mitsuhiro Kashiwaba, Masayuki Kamimura, Shin Hitachi, Eiji Itoi

Surgical and radiologic anatomy : SRA　35　(3)　205-10　2013/04

DOI： 10.1007/s00276-012-1011-2 　

ISSN： 0930-1038 1279-8517
X線診断Q&A Invited

相澤俊峰

整形外科　64　73-74　2013/04/01
Visualization of torn anterior cruciate ligament using 3-dimensional computed tomography. International-journal Peer-reviewed

Hiroaki Uozumi, Toshimi Aizawa, Takehiko Sugita, Tomonori Kunii, Shun Abe, Eiji Itoi

Orthopedic reviews　5　(3)　e22-102　2013

DOI： 10.4081/or.2013.e22 　

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Recently, a remnant-preserving anterior cruciate ligament (ACL) reconstruction technique has been developed. However, the preoperative condition of remnant ACL is occasionally difficult to evaluate by magnetic resonance imaging. The purpose of this study is to evaluate the accuracy of pre-operative visualization of remnant ACL using three-dimensional computed tomography (3D-CT). The remnant ACL in 25 patients was examined by 3DCT before ACL reconstruction surgery. Findings on 3D-CT images and arthroscopy were compared. The 3D-CT images were classified into 4 groups: Group A, remnant fibers attached to the posterior cruciate ligament (PCL); Group B, those located between the PCL and the lateral wall; Group C, those attached to the lateral wall; and Group D, no identifiable remnant fibers on the tibial side. These groups were made up of 4, 3, 9 and 9 patients, respectively. Findings on 3D-CT images were identical to those during arthroscopy in 20 of 25 cases (80%). Remnant ACL can be accurately evaluated using 3D-CT in 80% of cases of torn ACL. This novel method is a useful technique for pre-operative assessment of remnant ACL.
Epidemiology of surgically treated primary spinal cord tumors in Miyagi, Japan. International-journal Peer-reviewed

Hiroshi Ozawa, Toshimi Aizawa, Haruo Kanno, Hirotaka Sano, Eiji Itoi

Neuroepidemiology　41　(3-4)　156-60　2013

DOI： 10.1159/000353561 　

ISSN： 0251-5350 1423-0208
Tumors at the lateral portion of the C1-2 interlaminar space compressing the spinal cord by rotation of the atlantoaxial joint: new aspects of spinal cord compression. International-journal Peer-reviewed

Hiroshi Ozawa, Takashi Kusakabe, Toshimi Aizawa, Takeshi Nakamura, Yushin Ishii, Eiji Itoi

Journal of neurosurgery. Spine　17　(6)　552-5　2012/12

DOI： 10.3171/2012.9.SPINE12562 　

ISSN： 1547-5654
Natural history of intradural-extramedullary spinal cord tumors. International-journal Peer-reviewed

Hiroshi Ozawa, Yoshito Onoda, Toshimi Aizawa, Takeshi Nakamura, Tomoaki Koakutsu, Eiji Itoi

Acta neurologica Belgica　112　(3)　265-70　2012/09

DOI： 10.1007/s13760-012-0048-7 　

ISSN： 0300-9009
Neuroprotective therapy using granulocyte colony-stimulating factor for patients with worsening symptoms of thoracic myelopathy: a multicenter prospective controlled trial. International-journal

Tsuyoshi Sakuma, Masashi Yamazaki, Akihiko Okawa, Hiroshi Takahashi, Kei Kato, Mitsuhiro Hashimoto, Koichi Hayashi, Takeo Furuya, Takayuki Fujiyoshi, Junko Kawabe, Chikato Mannoji, Tomohiro Miyashita, Ryo Kadota, Yukio Someya, Osamu Ikeda, Tomonori Yamauchi, Masayuki Hashimoto, Toshimi Aizawa, Atsushi Ono, Shiro Imagama, Tokumi Kanemura, Hideki Hanaoka, Kazuhisa Takahashi, Masao Koda

Spine　37　(17)　1475-8　2012/08/01

eISSN： 1528-1159

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STUDY DESIGN: An open-labeled multicenter prospective controlled clinical trial. OBJECTIVE: To confirm the feasibility of granulocyte colony-stimulating factor (G-CSF) administration for patients with thoracic myelopathy. SUMMARY OF BACKGROUND DATA: Although G-CSF is best known as an important cytokine commonly used to treat neutropenia, it also has nonhematopoietic functions. Previous experimental studies have shown that G-CSF can enhance tissue regeneration of several organs, such as the heart and the brain. We previously reported that G-CSF promotes functional recovery after spinal cord injury in rodents. On the basis of those findings, we started a clinical trial of neuroprotective therapy, using G-CSF for patients with worsening symptoms of thoracic myelopathy. METHODS: Patients whose Japanese Orthopaedic Association (JOA) score for thoracic myelopathy had decreased 2 points or more during a recent 1-month period were eligible for entry. After giving informed consent, patients were assigned to G-CSF and control groups. The G-CSF group (n = 10) received G-CSF 10 μg/kg per day intravenously for 5 consecutive days. The control group (n = 14) received similar treatments as the G-CSF group except for G-CSF administration. The primary outcome was JOA recovery rate at 1 month after G-CSF administration or initial treatment. RESULTS: There was greater improvement in neurological functioning between baseline and 1-month follow-up in the G-CSF group (JOA recovery rate: 29.1 ± 20.5%) than in the control group (JOA recovery rate: 1.1 ± 4.2%) (P < 0.01). No serious adverse events occurred during or after the G-CSF administration. CONCLUSION: The results provide evidence that G-CSF administration caused neurological recovery in patients with worsening symptoms of thoracic compression myelopathy.
Response to the editorial comments by Dr. Vincent C. Traynelis on the article entitled “Spine-Shortening Osteotomy for Patients with Tethered Cord Syndrome Caused by Lipomyelomeningocele.” Peer-reviewed

Kokubun S Aizawa T

J Neurosurg Spine　15　19-20　2012/07
Prevalence of reoperation for perioperative complications in lumbar spinal surgery. Invited Peer-reviewed

Aizawa T Ozawa, H, Kusakabe, T, Nakamura T, Sekiguchi A, Koakutsu, T, Takahashi, K Morozumi, N, Koizumi Y, Itoi E

J Spine Res　3　149-153　2012/07
Dynamic changes in the dural Sac cross-sectional area on axial loaded MR imaging: Is there a difference between degenerative spondylolisthesis and spinal stenosis? Peer-reviewed

H. Ozawa, Haruo Kanno, Y. Koizumi, N. Morozumi, T. Aizawa, T. Kusakabe, Y. Ishii, E. Itoi

American Journal of Neuroradiology　33　(6)　1191-1197　2012/06

DOI： 10.3174/ajnr.A2920 　

ISSN： 0195-6108 1936-959X
Osteochondritis dissecans of the knee in identical twins: a report of two cases. International-journal Peer-reviewed

Satsuki Onoda, Takehiko Sugita, Toshimi Aizawa, Masahiro Ohnuma, Atsushi Takahashi

Journal of orthopaedic surgery (Hong Kong)　20　(1)　108-10　2012/04

ISSN： 1022-5536

eISSN： 2309-4990
Reoperation for recurrent lumbar disc herniation: a study over a 20-year period in a Japanese population. Peer-reviewed

Toshimi Aizawa, Hiroshi Ozawa, Takashi Kusakabe, Takeshi Nakamura, Akira Sekiguchi, Atsushi Takahashi, Tatsuro Sasaji, Shigeyuki Tokunaga, Tomonori Chiba, Naoki Morozumi, Yutaka Koizumi, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　17　(2)　107-13　2012/03

DOI： 10.1007/s00776-011-0184-6 　

ISSN： 0949-2658
Dynamic change of dural sac cross-sectional area in axial loaded magnetic resonance imaging correlates with the severity of clinical symptoms in patients with lumbar spinal canal stenosis. International-journal Peer-reviewed

Haruo Kanno, Hiroshi Ozawa, Yutaka Koizumi, Naoki Morozumi, Toshimi Aizawa, Takashi Kusakabe, Yushin Ishii, Eiji Itoi

Spine　37　(3)　207-13　2012/02/01

DOI： 10.1097/BRS.0b013e3182134e73 　

ISSN： 0362-2436

eISSN： 1528-1159
Fracture and contralateral dislocation of the twin facet joints of the lower cervical spine. International-journal Peer-reviewed

Ly Minh Ngo, Toshimi Aizawa, Takeshi Hoshikawa, Yasuhisa Tanaka, Tetsuro Sato, Yushin Ishii, Shoichi Kokubun

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　21　(2)　282-8　2012/02

DOI： 10.1007/s00586-011-1956-6 　

ISSN： 0940-6719
Remodeling capacity of malunited odontoid process fractures in kyphotic angulation in infancy: an observation up to maturity in three patients. International-journal Peer-reviewed

Shigeyuki Tokunaga, Yushin Ishii, Toshimi Aizawa, Yutaka Koizumi, Jun Kawai, Shoichi Kokubun

Spine　36　(23)　E1515-8-E1518　2011/11/01

DOI： 10.1097/BRS.0b013e31820f6da6 　

ISSN： 0362-2436
Incidence of medial plica in 3,889 knee joints in the Japanese population. International-journal Peer-reviewed

Akari Nakayama, Takehiko Sugita, Toshimi Aizawa, Atsushi Takahashi, Tetsuo Honma

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association　27　(11)　1523-7　2011/11

DOI： 10.1016/j.arthro.2011.06.022 　

ISSN： 0749-8063
最近の知見、新たな疾患概念の画像所見―脊髄ヘルニア Invited

相澤俊峰, 小澤浩司, 日下部隆, 中村豪, 井樋栄二

脊椎脊髄　23　447-450　2011/10
腰部脊柱管狭窄症の膀胱機能評価―JOAスコアと国際前立腺肥大症状スコア、尿流動態検査との比較. Peer-reviewed

高橋康平, 神尾一彦, 相澤俊峰, 佐藤信, 中川晴彦, 松下真史

整形災害外科　53　179-185　2011/10
環軸関節回旋により脊髄圧迫が生じたC2神経根腫瘍―2例報告 Peer-reviewed

日下部隆, 小澤浩司, 相澤俊峰, 中村豪, 石井祐信, 井樋栄二

東日本整災会誌　22　125-130　2011/10
仙腸関節障害に伴う下肢症状 Peer-reviewed

村上栄一, 野口京子, 黒澤大輔, 相澤俊峰

臨床整形外科　45　711-714　2011/10

DOI： 10.11477/mf.1408101777 　
腰部脊柱管狭窄症の膀胱機能評価―JOAスコアと国際前立腺肥大症状スコア、尿流動態検査との比較 Peer-reviewed

高橋康平, 神尾一彦, 相澤俊峰, 佐藤信, 中川晴彦, 松下真史

整形災害外科　53　179-185　2011/10
Can the fragment stability of osteochondritis dissecans be interpreted by arthroscopic findings alone? International-journal Peer-reviewed

Takehiko Sugita, Toshimi Aizawa, Hiroaki Uozumi

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association　27　(9)　1171-2　2011/09

DOI： 10.1016/j.arthro.2011.06.039 　

ISSN： 0749-8063
Response Peer-reviewed

Shoichi Kokubun, Toshimi Aizawa

Journal of Neurosurgery: Spine　15　(1)　20　2011/07

DOI： 10.3171/2010.12.SPINE10725 　

ISSN： 1547-5654 1547-5646
Spine-shortening osteotomy for patients with tethered cord syndrome caused by lipomyelomeningocele Peer-reviewed

Shoichi Kokubun, Hiroshi Ozawa, Toshimi Aizawa, Ngo Minh Ly, Yasuhisa Tanaka

JOURNAL OF NEUROSURGERY-SPINE　15　(1)　21-27　2011/07

DOI： 10.3171/2011.2.SPINE10114 　

ISSN： 1547-5654

eISSN： 1547-5646
Response to the editorial comments by Dr. Vincent C. Traynelis on the article entitled “Spine-Shortening Osteotomy for Patients with Tethered Cord Syndrome Caused by Lipomyelomeningocele.” Peer-reviewed

Kokubun S Aizawa T

J Neurosurg Spine　15　19-20　2011/07
骨組織球症―臨床・画像上の特徴と悪性腫瘍との鑑別― Peer-reviewed

保坂正美, 羽鳥正仁, 常陸真, 綿貫宗則, 相澤俊峰, 井樋栄二

整形災害外科　54　1159-1170　2011/07
Spine-shortening osteotomy for patients with tethered cord syndrome caused by lipomyelomeningocele. International-journal Peer-reviewed

Shoichi Kokubun, Hiroshi Ozawa, Toshimi Aizawa, Ngo Minh Ly, Yasuhisa Tanaka

Journal of neurosurgery. Spine　15　(1)　21-7　2011/07

DOI： 10.3171/2011.2.SPINE10114 　

ISSN： 1547-5654

eISSN： 1547-5646
Bony island within the articular cartilage of the knee in a child: a rare condition for early osteoarthritis. International-journal Peer-reviewed

Taku Hatta, Takehiko Sugita, Toshimi Aizawa, Masahiro Ohnuma, Atsushi Takahashi, Eiji Itoi

Orthopedic reviews　3　(1)　e7-29　2011/03/17

DOI： 10.4081/or.2011.e7 　

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Articular cartilage is a specific type of connective tissue composed of hydrated proteoglycans within a matrix of collagen fibrils. In the elderly population, it shows degenerative changes that may results in osteoarthritis. The more severe form of osteoarthritis occasionally demonstrates bone formation within the cartilage, which is designated as a bony protuberance, however, such lesions are rare in children. This report presents the case of a 10-year-old boy with a bony protuberance within the articular cartilage of the knee. The patient initially complained of knee pain and he subsequently developed flexion contracture. Radiological and arthroscopic examinations revealed a bony protuberance in the articular cartilage and degenerative changes of the cartilage above it. He was successfully treated by the removal of the bony protuberance and osteochondral grafting. The bony protuberance may have caused cartilage degradation since the thickness of the cartilage above it was thinner than that around the lesion. The bony protuberance within the articular cartilage formed in the younger population may be a possible cause of osteoarthritis. This case is a noteworthy with regard to the pathogenesis of osteoarthritis.
腰部脊柱管狭窄症の膀胱機能評価―JOAスコアと国際前立腺肥大症状スコア、尿流動態検査との比較 Peer-reviewed

高橋康平, 神尾一彦, 相澤俊峰, 佐藤信, 中川晴彦, 松下真史

整形災害外科　53　179-185　2010/11
環軸関節回旋により脊髄圧迫が生じたC2神経根腫瘍―2例報告 Peer-reviewed

日下部隆, 小澤浩司, 相澤俊峰, 中村豪, 石井祐信, 井樋栄二

東日本整災会誌　22　125-130　2010/10
仙腸関節障害に伴う下肢症状 Peer-reviewed

村上栄一, 野口京子, 黒澤大輔, 相澤俊峰

臨床整形外科　45　711-714　2010/10

DOI： 10.11477/mf.1408101777 　
脊椎巨細胞腫12例の検討 Peer-reviewed

関口玲, 小澤浩司, 相澤俊峰, 日下部隆, 中村豪, 保坂正美, 井樋栄二

東日本整形災害外科学会雑誌　22　(3)　466-466　2010/08
原発性脊椎腫瘍の手術成績 Peer-reviewed

山屋誠司, 小澤浩司, 相澤俊峰, 日下部隆, 中村豪, 関口玲, 保坂正美, 井樋栄二

東日本整形災害外科学会雑誌　22　(3)　465-465　2010/08
傍脊柱筋・大腰筋における脊柱支持機能の比較 Peer-reviewed

富谷明人, リチャード・リーバー, 相澤俊峰, 井樋栄二

日本整形外科スポーツ医学会雑誌　30　(4)　387-387　2010/08
C1/2 facet cyst revealed by facet joint arthrography. Peer-reviewed

Toshimi Aizawa, Hiroshi Ozawa, Takashi Kusakabe, Takeshi Nakamura, Pongsthorn Chanplakorn, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　15　(4)　603-7　2010/07

DOI： 10.1007/s00776-009-1472-2 　

ISSN： 0949-2658
最近の知見、新たな疾患概念の画像所見―脊髄ヘルニア Invited

相澤俊峰, 小澤浩司, 日下部隆, 中村豪, 井樋栄二

脊椎脊髄　23　447-450　2010/06
Clinical significance of intramedullary Gd-DTPA enhancement in cervical myelopathy. Peer-reviewed

Ozawa H, Sato T, Hyodo H, Ishii Y, Morozumi N, Koizumi Y, Matsumoto F, Kasama F, Aizawa T, Itoi E, Kokubun S

Spinal Cord　48　(5)　415-422　2010/05

DOI： 10.1038/sc.2009.152 　
Giant sacral schwannoma: a report of six cases. International-journal Peer-reviewed

Chanplakorn Pongsthorn, Hiroshi Ozawa, Toshimi Aizawa, Takashi Kusakabe, Takeshi Nakamura, Eiji Itoi

Upsala journal of medical sciences　115　(2)　146-52　2010/05

DOI： 10.3109/03009730903359674 　

ISSN： 0300-9734
Incidence of complications associated with spinal endoscopic surgery: nationwide survey in 2007 by the Committee on Spinal Endoscopic Surgical Skill Qualification of Japanese Orthopaedic Association. Invited Peer-reviewed

Morio Matsumoto, Toru Hasegawa, Manabu Ito, Toshimi Aizawa, Shinichi Konno, Masatsune Yamagata, Sohei Ebara, Yudo Hachiya, Hiroaki Nakamura, Shoji Yagi, Kimiaki Sato, Akira Dezawa, Muneto Yoshida, Kenichi Shinomiya, Yoshiaki Toyama, Katsuji Shimizu, Kensei Nagata

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　15　(1)　92-6　2010/01

DOI： 10.1007/s00776-009-1428-6 　

ISSN： 0949-2658
Comparison of cervical spinal canal diameter between younger and elder generations of Japanese. Peer-reviewed

Shin-ichi Goto, Jutaro Umehara, Toshimi Aizawa, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　15　(1)　97-103　2010/01

DOI： 10.1007/s00776-009-1427-7 　

ISSN： 0949-2658
Histologic findings and possible causes of osteochondritis dissecans of the knee. International-journal Peer-reviewed

Hiroaki Uozumi, Takehiko Sugita, Toshimi Aizawa, Atsushi Takahashi, Masahiro Ohnuma, Eiji Itoi

The American journal of sports medicine　37　(10)　2003-8　2009/10

DOI： 10.1177/0363546509346542 　

ISSN： 0363-5465
脊椎内視鏡下手術の現状ー2007年1月〜12月手術施行状況調査・インシデント報告集計結果ー. Peer-reviewed

松本守雄, 長谷川徹, 相澤俊峰, 猪川輪哉, 伊東学, 江原宗平, 岡治道, 加藤圭彦, 川上守, 川原範夫, 古賀公明, 紺野慎一, 西良浩一, 坂本直俊, 佐藤公治, 佐藤公昭, 高野裕一, 高橋誠, 田中雅人, 出沢明, 中野恵介, 中村博亮, 夏山元伸, 長谷川和宏, 蜂谷裕道, 平泉裕, 藤本吉範, 前川慎吾, 前田健, 松本守雄, 三上靖夫, 望月眞人, 八木省次, 山縣正庸, 山元拓哉, 湯澤洋平, 清水克時, 四宮謙一, 戸山芳昭, 吉田宗人

日本整形外科学会雑誌　83　56-61　2009/10
胸部脊髄症の現況 Invited

佐藤哲朗, 相澤俊峰

脊椎脊髄ジャーナル　22　136-141　2009/10
脊椎内視鏡下手術の現状-2008年1月〜12月手術施行状況調査・インシデント報告集計結果- Peer-reviewed

松本守雄, 長谷川徹, 伊藤学, 相澤俊峰, 紺野慎一, 山縣正庸, 江原宗平, 蜂谷裕道, 中村博亮, 八木省次, 佐藤公昭, 出沢明, 吉田宗人, 戸山芳昭, 清水克時, 永田見生

日本整形外科学会雑誌　83　1022-1027　2009/10
離断性骨軟骨炎に対する組織学的検討 Peer-reviewed

高橋敦, 相澤俊峰, 大沼正宏, 井樋栄二, 杉田健彦, 魚住弘明, 田代茂義

東北膝関節研究会会誌　19　53-57　2009/10
Facet cyst hematoma in the lumbar spine: hematoma produced by bleeding into a pre-existing juxtafacet cyst. Peer-reviewed

Miyatake N Aizawa T, Hyodo, H, Sasaki H, Kusakabe, T, Sato T

J Orthop Surg　17　80-84　2009/04/01
T1 radiculopathy caused by intervertebral disc herniation: symptomatic and neurological features. Peer-reviewed

Haruo Kanno, Toshimi Aizawa, Yasuhisa Tanaka, Takeshi Hoshikawa, Hiroshi Ozawa, Eiji Itoi, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　14　(1)　103-6　2009/01

DOI： 10.1007/s00776-008-1276-9 　

ISSN： 0949-2658
Severe facet joint arthrosis caused c7/t1 myelopathy: a case report. International-journal Peer-reviewed

Toshimi Aizawa, Hiroshi Ozawa, Takeshi Hoshikawa, Takashi Kusakabe, Eiji Itoi

Case reports in medicine　2009　481459-481459　2009

DOI： 10.1155/2009/481459 　

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Cervical myelopathy is caused by degenerative processes of the spine including intervertebral disc herniation and posterior spur usually developing at C3/4 to C5/6. C7/T1 single level myelopathy is very rare because of the anatomical characteristics. Facet joint arthrosis can be a cause of cervical myelopathy but only a few cases have been reported. The authors report an extremely rare case of C7/T1 myelopathy caused by facet joint arthrosis. A 58-year-old male presented with hand and gait clumsiness. The radiological examinations revealed severe C7/T1 facet joint arthrosis with bony spur extending into the spinal canal, which compressed the spinal cord laterally. The T1 spinous process indicated nonunion of a "clay-shoveler's" fracture, which suggested that his cervico-thoracic spine had been frequently moved, and thus severe arthrosis had occurred in the facet joints. A right hemilaminectomy of C7 and C7/T1 facetectomy with single level spinal fusion led to complete neurological improvement.
Diagram specific to sacroiliac joint pain site indicated by one-finger test. Peer-reviewed

Eiichi Murakami, Toshimi Aizawa, Kyoko Noguchi, Haruo Kanno, Hiroshi Okuno, Hiroaki Uozumi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　13　(6)　492-7　2008/11
Publisher: Springer Japan
DOI： 10.1007/s00776-008-1280-0 　

ISSN： 0949-2658
黄色靭帯骨化による胸部脊髄症 Invited

相澤俊峰

整形外科　59　1277-1280　2008/09
Spine-shortening vertebral osteotomy in a patient with tethered cord syndrome and a vertebral fracture. Case report. International-journal Peer-reviewed

Haruo Kanno, Toshimi Aizawa, Hiroshi Ozawa, Takeshi Hoshikawa, Eiji Itoi, Shoichi Kokubun

Journal of neurosurgery. Spine　9　(1)　62-6　2008/07

DOI： 10.3171/SPI/2008/9/7/062 　

ISSN： 1547-5654
Sagittal alignment changes after thoracic laminectomy in adults. International-journal Peer-reviewed

Toshimi Aizawa, Tetsuro Sato, Hiroshi Ozawa, Naoki Morozumi, Fujio Matsumoto, Hirotoshi Sasaki, Takeshi Hoshikawa, Chikashi Kawahara, Shoichi Kokubun, Eiji Itoi

Journal of neurosurgery. Spine　8　(6)　510-6　2008/06

DOI： 10.3171/SPI/2008/8/6/510 　

ISSN： 1547-5654
Normal bone growth requires optimal estrogen levels: negative effects of both high and low dose estrogen on the number of growth plate chondrocytes. Peer-reviewed

Hiroyuki Takano, Toshimi Aizawa, Taichi Irie, Eiji Itoi, Shoichi Kokubun, Helmtrud I Roach

The Tohoku journal of experimental medicine　214　(3)　269-80　2008/03

DOI： 10.1620/tjem.214.269 　

ISSN： 0040-8727

eISSN： 1349-3329
腰部脊柱管狭窄症における荷重MRIの検討. Peer-reviewed

菅野晴夫, 小澤浩司, 相澤俊峰, 星川健, 川原央, 井樋栄二

東日本整災誌　20　(1)　60-64　2008

ISSN： 1342-7784
Response to the letter from Dr. Kong and Wang. Peer-reviewed

Aizawa T, Sato T, J Neurosurg

J Neurosurg (spine)　6　377-378　2007/12
Crowned Dens syndrome. International-journal Peer-reviewed

Shinichi Goto, Jutaro Umehara, Toshimi Aizawa, Shoichi Kokubun

The Journal of bone and joint surgery. American volume　89　(12)　2732-6　2007/12

DOI： 10.2106/JBJS.F01322 　

ISSN： 0021-9355

eISSN： 1535-1386
Spinal dumbbell tumors: an analysis of a series of 118 cases. International-journal Peer-reviewed

Hiroshi Ozawa, Shoichi Kokubun, Toshimi Aizawa, Takeshi Hoshikawa, Chikashi Kawahara

Journal of neurosurgery. Spine　7　(6)　587-93　2007/12

DOI： 10.3171/SPI-07/12/587 　

ISSN： 1547-5654
慢性仙腸関節性疼痛に対する仙腸関節前方固定術 Peer-reviewed

村上栄一, 菅野晴夫, 相澤俊峰, 奥野洋史, 野口京子

日本腰痛会誌　13　(1)　197-203　2007/11
Publisher: The Japanese Society of Lumbar Spine Disorders
DOI： 10.3753/yotsu.13.197 　

ISSN： 1345-9074

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Sacroiliac joint (SIJ) arthrodesis through anterior approach was performed for 15 patients with severe SIJ pain. All patients were not adequately responsive to the conservative treatments including sacroiliac joint injection and stabilization by pelvic belts, and were markedly restricted their activity of daily living and working. They were 6 males and 9 females and the averaged age at surgery was 49 years old (range; 30-86). The mean duration of preoperative symptoms was 3.9 years (range; 1-7) and the postoperative follow-up period was averaged 2.3 years (6 months-5 years). Unilateral SIJ arthrodesis was performed for 14 patients and bilateral for 1 patient. CT scan confirmed that the SIJ were completely fused in all cases. The preoperative JOA score was 5.6 (4-9, full mark is 29 points) and improved to 18 (7-24). Visual analogue scale of pain (VAS) was 84 (70-93) preoperatively and decreased to 40 (10-75) after surgery. Roland-Morris disability questionnaire (RDQ) score was also improved from 21.1 (17-23, worst is 24 ) to 6.9 (1-14). The surgical outcome of SIJ arthrodesis through anterior approach was relatively good but the indication and timing of surgery still need some discussions.
下垂手（drop finger）をきたす頚部神経根症. Peer-reviewed

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

臨整外　39　475-480　2007/10
Results of surgical treatment for thoracic myelopathy: minimum 2-year follow-up study in 132 patients. International-journal Peer-reviewed

Toshimi Aizawa, Tetsuro Sato, Hirotoshi Sasaki, Fujio Matsumoto, Naoki Morozumi, Takashi Kusakabe, Eiji Itoi, Shoichi Kokubun

Journal of neurosurgery. Spine　7　(1)　13-20　2007/07

DOI： 10.3171/SPI-07/07/013 　

ISSN： 1547-5654
Estrogen deficiency leads to decrease in chondrocyte numbers in the rabbit growth plate. Peer-reviewed

Hiroyuki Takano, Toshimi Aizawa, Taichi Irie, Shoichi Kokubun, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　12　(4)　366-74　2007/07

DOI： 10.1007/s00776-007-1145-y 　

ISSN： 0949-2658
Effect of periarticular and intraarticular lidocaine injections for sacroiliac joint pain: prospective comparative study. Peer-reviewed

Eiichi Murakami, Yasuhisa Tanaka, Toshimi Aizawa, Masato Ishizuka, Shoichi Kokubun

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　12　(3)　274-80　2007/05

DOI： 10.1007/s00776-007-1126-1 　

ISSN： 0949-2658
医療費からみた内視鏡下腰椎椎間板ヘルニア摘出術の評価 Peer-reviewed

相澤俊峰, 佐々木祐肇, 佐藤哲朗

整形外科　58　217-219　2007/04
Ki-67標識率による脊髄神経鞘腫の増殖能の検討 Peer-reviewed

小澤浩司, 渡辺みか, 菅野晴夫, 川原央, 星川健, 相澤俊峰

日本脊椎脊髄病学会雑誌　18　(2)　559-559　2007/03
Effect of resting interval for muscle regeneration in mice. International-journal Peer-reviewed

Aizawa Sasaki, Toshimi Aizawa, Akihito Tomiya, Yoshihiro Matsubara, Shoichi Kokubun, Eiji Itoi

Upsala journal of medical sciences　112　(2)　175-81　2007

ISSN： 0300-9734

eISSN： 2000-1967
Thoracic myelopathy caused by ossification of the ligamentum flavum: clinical features and surgical results in the Japanese population. International-journal Peer-reviewed

Toshimi Aizawa, Tetsuro Sato, Hirotoshi Sasaki, Takashi Kusakabe, Naoki Morozumi, Shoichi Kokubun

Journal of neurosurgery. Spine　5　(6)　514-9　2006/12

DOI： 10.3171/spi.2006.5.6.514 　

ISSN： 1547-5654
Facet cyst in the lumbar spine: radiological and histopathological findings and possible pathogenesis. International-journal Peer-reviewed

Takashi Kusakabe, Fumio Kasama, Toshimi Aizawa, Tetsuro Sato, Shoichi Kokubun

Journal of neurosurgery. Spine　5　(5)　398-403　2006/11

DOI： 10.3171/spi.2006.5.5.398 　

ISSN： 1547-5654
Thoracic myelopathy in Japan: epidemiological retrospective study in Miyagi Prefecture during 15 years. Peer-reviewed

Toshimi Aizawa, Tetsuro Sato, Yasuhisa Tanaka, Hiroshi Ozawa, Takeshi Hoshikawa, Yushin Ishii, Naoki Morozumi, Kentaro Ishibashi, Fumio Kasama, Hironori Hyodo, Eiichi Murakami, Takeshi Nishihira, Shoichi Kokubun

The Tohoku journal of experimental medicine　210　(3)　199-208　2006/11
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.210.199 　

ISSN： 0040-8727
One-stage lateral rhachotomy and posterior spinal fusion with compression hooks for Pott’s paralysis in the elderly. Peer-reviewed

Wang B Ozawa, H, Tanaka Y, Matsumoto, F Aizawa T, Kokubun S

J Orthop Surg.　14　310-314　2006/10
日本整形外科学会脊椎内視鏡下手術・技術認定制度委員会: 日本の内視鏡下手術技術認定制度と脊椎内視鏡下手術の現状. Peer-reviewed

谷川徹, 相澤俊峰, 猪川輪哉, 伊東学, 江原宗平, 岡治道, 加藤真介, 加藤圭彦, 川上守, 川原範夫, 古賀公明, 紺野慎一, 坂本直俊, 佐藤公治, 佐藤公昭, 高野裕一, 高橋誠, 田中雅人, 出沢明, 中野恵介, 中村博亮, 夏山元伸, 長谷川和宏, 蜂谷裕道, 平泉裕, 藤本吉範, 前川慎吾, 前田健, 松本守雄, 三上靖夫, 望月眞人, 八木省次, 山縣正庸, 山元拓哉, 湯澤洋平, 吉田宗人, 四宮謙一, 戸山芳昭

日整会誌　80　754-761　2006/10
脊髄ヘルニアと脊髄嚢腫性病変の治療戦略ー方針決定に必要な情報とその提供ー. Invited Peer-reviewed

相澤俊峰, 田中靖久, 星川健, 日下部隆, 中條悟, 国分正一

脊椎脊髄ジャーナル　19　717-724　2006/10
Surgery for ossification of the ligamentum flavum Peer-reviewed

Yasuhisa Tanaka, Tetsuro Sato, Toshimi Aizawa

OPLL: Ossification of the Posterior Longitudinal Ligament　265-269　2006
Publisher: Springer Japan
DOI： 10.1007/978-4-431-32563-5_37 　
Lumbar discal cyst followed by intervertebral disc herniation: MRI findings of two cases. Peer-reviewed

Masako Tokunaga, Toshimi Aizawa, Hironori Hyodo, Hirotoshi Sasaki, Yasuhisa Tanaka, Tetsuro Sato

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　11　(1)　81-4　2006/01

DOI： 10.1007/s00776-005-0961-1 　

ISSN： 0949-2658
筋性斜頚成長終了例と胸鎖乳突筋筋腹切離術. Peer-reviewed

星川健, 国分正一, 相澤俊峰, 田中靖久, 北純

整形災害外科　48　233-239　2005/10
脊髄係留症候群に対する脊柱短縮術. Peer-reviewed

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

臨整外　40　633-637　2005/10

DOI： 10.11477/mf.1408100118 　
The role of sex hormones in the kinetics of chondrocytes in the growth plate - A study in the rabbit Peer-reviewed

T Irie, T Aizawa, S Kokubun

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME　87B　(9)　1278-1284　2005/09

DOI： 10.1302/0301-620X.87B9.15583 　

ISSN： 0301-620X
Signal intensity changes on MRI during the healing process of spinal Langerhans cell granulomatosis: report of two cases. International-journal Peer-reviewed

Toshimi Aizawa, Tetsuro Sato, Yasuhisa Tanaka, Shoichi Kokubun

Journal of spinal disorders & techniques　18　(1)　98-101　2005/02

DOI： 10.1097/01.bsd.0000112040.70321.c1 　

ISSN： 1536-0652
Gorham disease of the spine: a case report and treatment strategies for this enigmatic bone disease. Peer-reviewed

Toshimi Aizawa, Tetsuro Sato, Shoichi Kokubun

The Tohoku journal of experimental medicine　205　(2)　187-96　2005/02

DOI： 10.1620/tjem.205.187 　

ISSN： 0040-8727
下垂手（drop finger）をきたす頚部神経根症. Peer-reviewed

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

臨整外　39　475-480　2004/10

DOI： 10.11477/mf.1408100419 　
Kummell病に対する後方進入脊柱短縮術. Peer-reviewed

田中靖久, 国分正一, 小澤浩司, 松本不二夫, 相澤俊峰, 星川健

日整会誌　78　265-269　2004/10
Myofibers express IL-6 after eccentric exercise Peer-reviewed

A Tomiya, T Aizawa, R Nagatomi, H Sensui, S Kokubun

AMERICAN JOURNAL OF SPORTS MEDICINE　32　(2)　503-508　2004/03

DOI： 10.1177/0095399703258788 　

ISSN： 0363-5465
Myofibers express IL-6 after eccentric exercise. International-journal Peer-reviewed

Akihito Tomiya, Toshimi Aizawa, Ryoichi Nagatomi, Hiroomi Sensui, Shoichi Kokubun

The American journal of sports medicine　32　(2)　503-8　2004/03

DOI： 10.1177/0095399703258788 　

ISSN： 0363-5465
Impaired fracture healing in the absence of TNF-alpha signaling: The role of TNF-alpha in endochondral cartilage resorption Peer-reviewed

LC Gerstenfeld, TJ Cho, T Kon, T Aizawa, A Tsay, J Fitch, GL Barnes, DT Graves, TA Einhorn

JOURNAL OF BONE AND MINERAL RESEARCH　18　(9)　1584-1592　2003/09

DOI： 10.1359/jbmr.2003.18.9.1584 　

ISSN： 0884-0431
Successful treatment for rhabdomyosarcoma by total spondylectomy in a child. Peer-reviewed

Takeshi Saito, Toshimi Aizawa, Osamu Kashimoto, Tetsuro Sato, Shoichi Kokubun

The Tohoku journal of experimental medicine　198　(4)　251-8　2002/12

DOI： 10.1620/tjem.198.251 　

ISSN： 0040-8727

eISSN： 1349-3329
終糸発生傍神経節腫の一例 Peer-reviewed

渡辺みか, 相澤俊峰, 森谷卓也, 笹野公伸

日本内分泌学会雑誌　78　(2)　494-494　2002/09
Intramedullary plasma cell granuloma in the cervicothoracic spine. Case report. International-journal Peer-reviewed

Toshimi Aizawa, Tetsuro Sato, Yasuhisa Tanaka, Koshi Kishimoto, Mika Watanabe, Shoichi Kokubun

Journal of neurosurgery　97　(2 Suppl)　235-8　2002/09

ISSN： 0022-3085
Medial superior cluneal nerve entrapment neuropathy in teenagers: a report of two cases. Peer-reviewed

Tarek A Aly, Yasuhisa Tanaka, Toshimi Aizawa, Hiroshi Ozawa, Shoichi Kokubun

The Tohoku journal of experimental medicine　197　(4)　229-31　2002/08

DOI： 10.1620/tjem.197.229 　

ISSN： 0040-8727

eISSN： 1349-3329
Idiopathic herniation of the thoracic spinal cord: report of three cases. Peer-reviewed

Aizawa T, Sato T, Tanaka Y, Kotajima S, Sekiya M, Kokubun S

Spine　26　(20)　E488-91　2001/10/15
Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha Peer-reviewed

T Aizawa, T Kon, TA Einhorn, LC Gerstenfeld

JOURNAL OF ORTHOPAEDIC RESEARCH　19　(5)　785-796　2001/09

DOI： 10.1016/S0736-0266(00)00078-4 　

ISSN： 0736-0266
髄内形質細胞肉芽腫(Plasma cell granuloma)の1例 Peer-reviewed

相澤俊峰, 佐藤哲朗, 田仲靖久, 国分正一, 渡辺みか

東北整形災害外科紀要　45　(1)　150-150　2001/06
Expression of osteoprotegerin, receptor activator of NF-kappa B ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing Peer-reviewed

T Kon, TJ Cho, T Aizawa, M Yamazaki, N Nooh, D Graves, LC Gerstenfeld, TA Einhorn

JOURNAL OF BONE AND MINERAL RESEARCH　16　(6)　1004-1014　2001/06

ISSN： 0884-0431
Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling Peer-reviewed

LC Gerstenfeld, TJ Cho, T Kon, T Aizawa, J Cruceta, BD Graves, TA Einhorn

CELLS TISSUES ORGANS　169　(3)　285-294　2001

DOI： 10.1159/000047893 　

ISSN： 1422-6405
c-Myc protein in the rabbit growth plate - Changes in immunolocalisation with age and possible roles from proliferation to apoptosis Peer-reviewed

T Aizawa, S Kokubun, T Kawamata, Y Tanaka, HI Roach

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME　81B　(5)　921-925　1999/09

DOI： 10.1302/0301-620X.81B5.9492 　

ISSN： 0301-620X
脊髄サルコイドーシスの1例 Peer-reviewed

古泉豊, 佐藤哲朗, 相澤俊峰, 国分正一, 高橋俊明

東北整形災害外科紀要　42　(2)　277-277　1998/12
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
Changes in the expression of Fas, osteonectin and osteocalcin with age in the rabbit growth plate Peer-reviewed

T Aizawa, HI Roach, S Kokubun, Y Tanaka

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME　80B　(5)　880-887　1998/09

DOI： 10.1302/0301-620X.80B5.8430 　

ISSN： 0301-620X
Paraparesis associated with mild congenital kyphoscoliosis in an adult Peer-reviewed

T Sato, S Kokubun, Y Tanaka, T Aizawa

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　183　(4)　303-308　1997/12

DOI： 10.1620/tjem.183.303 　

ISSN： 0040-8727

eISSN： 1349-3329
Apoptosis and proliferation of growth plate chondrocytes in rabbits Peer-reviewed

T Aizawa, S Kokubun, Y Tanaka

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME　79B　(3)　483-486　1997/05

DOI： 10.1302/0301-620X.79B3.7221 　

ISSN： 0301-620X
Extradural granulocytic sarcoma of the thoracic spine in acute myelogenous leukemia with 8;21 chromosome translocation Peer-reviewed

T Aizawa, S Kokubun, M Hatori, O Kashimoto, R Ichinohasama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　178　(4)　431-436　1996/04

DOI： 10.1620/tjem.178.431 　

ISSN： 0040-8727

eISSN： 1349-3329

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Misc. 115

脊椎後弯症患者の立位静止時と歩行時における体幹前傾と股関節肢位の関係

石川圭佑, 関口雄介, 高橋康平, 日下部詢弥, 馬場一慈, 八幡健一郎, 藤田涼, 橋本功, 海老原覚, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　98　(3)　2024

ISSN： 0021-5325
後弯症において歩行速度と関連する因子は何か-大腰筋角という新たな指標の提案-

石川圭佑, 高橋康平, 関口雄介, 日下部詢弥, 馬場一慈, 八幡健一郎, 藤田涼, 橋本功, 海老原覚, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　98　(3)　2024

ISSN： 0021-5325
サルコペニアと後弯症:後弯症患者の歩行速度に関与する因子-三次元動作解析装置を用いた歩行解析とレントゲン計測による検討-

石川圭佑, 高橋康平, 関口雄介, 大野木孝嘉, 馬塲一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本骨粗鬆症学会雑誌　9　(Suppl.1 (CD-ROM))　2023

ISSN： 2189-8383
TiNbSn合金で開発した人工股関節ステムの5年以上経過例の中期成績

千葉大介, 山田則一, 大山正瑞, 大津進, 桑原功行, 馬場一慈, 田中秀達, 花田修治, 井樋栄二, 相澤俊峰

日本整形外科学会雑誌　97　(2)　2023

ISSN： 0021-5325
投球障害肩・肘を有する選手とdeep squat testとの関連性(The relationship between deep squat test and players with disabled throwing shoulder/elbow)

Nagamoto Hideaki, Muraki Takayuki, Abe Masaya, Kimura Rei, Shinagawa Kiyotsugu, Yaguchi Haruki, Kurokawa Daisuke, Takahashi Hiroyuki, Yamamoto Nobuyuki, Aizawa Toshimi, Kumai Tsukasa

日本整形外科学会雑誌　96　(3)　S739-S739　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
投球肩および/あるいは投球肘に障害を有する選手は蹴り足のheel raise testで有意な陽性反応を示す(Players with disabled throwing shoulder and/or elbow show significant positive heel raise test of their kicking leg)

Nagamoto Hideaki, Muraki Takayuki, Abe Masaya, Kimura Rei, Shinagawa Kiyotsugu, Yaguchi Haruki, Kurokawa Daisuke, Takahashi Hiroyuki, Yamamoto Nobuyuki, Aizawa Toshimi, Kumai Tsukasa

日本整形外科学会雑誌　96　(3)　S742-S742　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Hip and knee position in patients with spinal kyphosis: Gait analysis with three-dimensional motion capture system

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 藤田涼, 大野木孝嘉, 馬塲一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

Journal of Spine Research (Web)　13　(3)　2022

ISSN： 2435-1563
局所麻酔・意識下,全内視鏡下腰椎手術と合併症回避の意義

山屋誠司, 橋本功, 古泉豊, 鈴木学, 須田英明, 八幡健一郎, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本整形外科学会雑誌　96　(2)　2022

ISSN： 0021-5325
全内視鏡除圧からKLIF固定まで:教育システムの提言

山屋誠司, 橋本功, 古泉豊, 鈴木学, 須田英明, 八幡健一郎, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本整形外科学会雑誌　96　(2)　2022

ISSN： 0021-5325
Investigation of load transfer site and timing of the sacroiliac joint surface during bipedal walking using an android model

佐中孝二, 黒澤大輔, 村上栄一, 橋本功, 相澤俊峰

整形外科　73　(3)　2022

ISSN： 0030-5901
仙腸関節固定術後の仙結節靱帯部痛の頻度と経過

黒澤大輔, 黒澤大輔, 佐々木健, 村上栄一, 村上栄一, 橋本功, 相澤俊峰

日本整形外科学会雑誌　96　(3)　2022

ISSN： 0021-5325
Hip-sacroiliac syndrome(仮称)の検討(FAIS股関節鏡視下手術例)

野口森幸, 村上栄一, 橋本功, 黒澤大輔, 相澤俊峰

日本整形外科学会雑誌　96　(3)　2022

ISSN： 0021-5325
前額断MRIによる腰椎椎間孔部狭窄の診断の信頼性と再現性-T1・T2強調画像の信頼性・再現性の比較-

橋本功, 橋本功, 田中靖久, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 高橋康平, 鈴木学, 大野木孝嘉, 古泉豊, 国分正一, 相澤俊峰

日本整形外科学会雑誌　96　(3)　2022

ISSN： 0021-5325
軽微な外傷で生じたアキレス腱部分断裂の一例

佐藤宏陽, 永元英明, 藍澤一穂, 品川清嗣, 相澤俊峰

日本足の外科学会雑誌　42　(Suppl.)　S246-S246　2021/10
Publisher: (一社)日本足の外科学会
ISSN： 0916-7927
高校生アスリートに対する鏡視下足関節外側靱帯修復術の治療成績

永元英明, 木村礼, 畠英里, 相澤俊峰, 熊井司

日本足の外科学会雑誌　42　(Suppl.)　S346-S346　2021/10
Publisher: (一社)日本足の外科学会
ISSN： 0916-7927
TiNbSn合金で開発した人工股関節ステムの3年以上経過例の短期成績

千葉大介, 山田則一, 大山正瑞, 大津進, 桑原功行, 馬場一慈, 田中秀達, 花田修治, 井樋栄二, 相澤俊峰

日本股関節学会学術集会プログラム・抄録集　48th　2021
馬尾に発生した悪性リンパ腫の1例

鈴木学, 相澤俊峰, 橋本功, 高橋康平, 半田恭一, 井樋栄二

東北整形災害外科学会プログラム・抄録集　118th　2021
全身性疾患に伴う脊椎病変~腫瘍性疾患(脊椎転移など)と脊椎病変~

大野木孝嘉, 高橋康平, 橋本功, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　118th　2021
思春期に診断されたposterior hemivertebraに対して短縮骨切り術を施行した1例

高橋康平, 半田恭一, 大野木孝嘉, 橋本功, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　118th　2021
MRIによるEden分類2型と3型の脊髄砂時計腫の鑑別

木村礼, 橋本功, 高橋正樹, 半田恭一, 鈴木学, 高橋康平, 相澤俊峰

東北整形災害外科学会プログラム・抄録集　118th　2021
Anterior decompression through a posterior approach for the patients with thoracic myelopathy caused by ossification of posterior longitudinal ligament: Surgical outcomes and validation of decompression using CT scan

高橋康平, 相澤俊峰, 橋本功, 小野田祥人, 半田恭一, 大野木孝嘉, 菅野晴夫, 小澤浩司

Journal of Spine Research (Web)　12　(3)　2021

ISSN： 2435-1563
Spinal shortening osteotomy using dynamic compression hook system for adult spinal deformity

菅野晴夫, 菅野晴夫, 相澤俊峰, 橋本功, 小澤浩司

Journal of Spine Research (Web)　12　(3)　2021

ISSN： 2435-1563
Surgical outcome of the patients with ossification of posterior longitudinal ligament in the thoracic spine: Retrospective comparison of surgical outcomes between posterior decompression and instrumented spinal fusion and anterior decompression through posterior approach for patients with ossification of posterior longitudinal ligament in thoracic spine

相澤俊峰, 橋本功, 高橋康平, 大野木孝嘉, 半田恭一, 菅野晴夫, 小澤浩司

Journal of Spine Research (Web)　12　(3)　2021

ISSN： 2435-1563
Neurological deficits after nerve root sacrifice on schwannoma extirpation

半田恭一, 相澤俊峰, 村上大史, 大野木孝嘉, 高橋康平, 橋本功, 小澤浩司, 井樋栄二

Journal of Spine Research (Web)　12　(3)　2021

ISSN： 2435-1563
Validation study for MRI-based diagnostic algorithm to differentiate between meningiomas and schwannomas

村上大史, 相澤俊峰, 半田恭一, 大野木孝嘉, 鈴木学, 高橋康平, 小野田祥人, 橋本功, 小澤浩司, 井樋栄二

Journal of Spine Research (Web)　12　(3)　2021

ISSN： 2435-1563
Novel anterior decompression technique through a posterior approach using a curved drill and T-saw for ossification of posterior longitudinal ligament in the thoracic spine: Safe and secure decompression prevents postoperative neurological deterioration and enables early postoperative ambulation

菅野晴夫, 菅野晴夫, 相澤俊峰, 橋本功, 高橋康平, 半田恭一, 井樋栄二, 小澤浩司

Journal of Spine Research (Web)　12　(3)　2021

ISSN： 2435-1563
胸椎OPLLに対する弯曲型ドリルとT-sawを用いた安全・確実な後方進入前方除圧-術後の麻痺悪化の回避と早期離床の促進-

菅野晴夫, 相澤俊峰, 橋本功, 小澤浩司, 小澤浩司

日本脊椎インストゥルメンテーション学会抄録集　30th　2021
腰椎変性すべり症に対する全内視鏡下トランスカンビン腰椎椎体間固定術(KLIF)の有用性と課題

山屋誠司, 橋本功, 古泉豊, 鈴木学, 須田英明, 八幡健一郎, 川原央, 両角直樹, 国分正一, 相澤俊峰

日本内視鏡外科学会総会(Web)　34th　2021
Coronal MRI for diagnosis of lumbar foraminal stenosis: A comparative study of reliability, reproducibility and interpretation between T1 and T2-weighted images

橋本功, 田中靖久, 相澤俊峰, 椿野巧, 中川智刀, 舘田聡, 高橋康平, 鈴木学, 大野木孝嘉, 両角直樹, 古泉豊, 佐藤哲朗, 小澤浩司, 菅野晴夫, 国分正一, 井樋栄二

Journal of Spine Research (Web)　12　(3)　2021

ISSN： 2435-1563
Surgical outcomes of anterior decompression through a posterior approach for the patients with thoracic myelopathy caused by ossification of the posterior longitudinal ligament

相澤俊峰, 橋本功, 菅野晴夫, 半田恭一, 小野田祥人, 井樋栄二, 小澤浩司

Journal of Spine Research (Web)　11　(3)　2020

ISSN： 2435-1563
Novel procedure of anterior decompression through posterior approach for ossification of posterior longitudinal ligament in the thoracic spine: Safe and secure decompression using a curved drill and T-saw

菅野晴夫, 相澤俊峰, 橋本功, 衛藤俊光, 井樋栄二

Journal of Spine Research (Web)　11　(3)　2020

ISSN： 2435-1563
片側椎間関節切除に固定術を併用しない胸椎砂時計腫摘出術の中長期成績:多施設研究

石川裕也, 大橋正幸, 平野徹, 渡辺慶, 松田倫治, 菅野晴夫, 橋本功, 半田恭一, 相澤俊峰, 赤羽武, 鈴木智人, 嶋村之秀

東北整形災害外科学会雑誌　63　(1)　2020

ISSN： 1348-8694
Spontaneous regression of a thoracic dumbbell tumor: A case report

鈴木学, 相澤俊峰, 橋本功, 菅野晴夫, 小野田祥人, 井樋栄二

東日本整形災害外科学会雑誌(Web)　32　(2)　2020

ISSN： 2433-569X
Surgical Approach to Pigmented Villonodular Synovitis and Synovial Osteochondromatosis in Pathological Expansion of the Popliteus Bursa. International-journal

Takehiko Sugita, Nobuyuki Itaya, Toshimi Aizawa, Masayuki Kamimura, Atsushi Takahashi, Naohisa Miyatake

Arthroscopy techniques　8　(12)　e1495-e1499　2019/12

DOI： 10.1016/j.eats.2019.07.028 　

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We orthopaedic surgeons are not familiar with the popliteus bursa. It is defined as the expansion in the synovial membrane of the posterolateral part of the knee that lies between the lateral meniscus and the tendon of the popliteus muscle. The popliteus bursa extends approximately 1 cm distal to the joint line and has 4 borders; the medial border is the peripheral margin of the lateral meniscus, the lateral border is the popliteus tendon, and the superior and inferior borders are formed by 2 fascicles. We very rarely observe cystic lesions that expand more distally, such as pigmented villonodular synovitis (PVNS) and synovial osteochondromatosis. We consider the distally expanded bursa as the pathologic expansion of the popliteus bursa. When this expansion is involved with PVNS, it may be the cause of recurrence of PVNS in the knee joint. Synovial osteochondromatosis in this expansion may cause pain in the posterolateral corner of the knee and may become a source of free bodies in the knee joint. In such conditions, these lesions should be surgically excised. The purpose of this Technical Note is to describe a surgical approach to the pathologic expansion of the popliteus bursa.
不安定型骨盤輪骨折に対するDual‐SAI screwsを用いた整復固定術―Extended tab screwによるreduction technique―

小野田祥人, 小野田祥人, 菅野晴夫, 相澤俊峰, 橋本功, 大柳琢, 大柳琢, 久志本成樹, 井樋栄二

東日本整形災害外科学会雑誌　31　(3)　435-435　2019/08/05
Publisher: 東日本整形災害外科学会
ISSN： 1342-7784

eISSN： 2433-569X
Destructive discovertebral degenerative diseaseの1例

松田倫治, 相澤俊峰, 橋本功, 菅野晴夫, 山屋誠司, 衛藤俊光, 半田恭一, 井樋栄二

東北整形災害外科学会雑誌　62　(1)　154-154　2019/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
除圧固定術後に麻痺が増悪した胸椎OPLLの検討

相澤俊峰, 衛藤俊光, 菅野晴夫, 小野田祥人, 橋本功, 半田恭一, 半田恭一, 小澤浩司

Journal of Spine Research　10　(3)　2019

ISSN： 1884-7137
脊柱靭帯骨化症に関する調査研究胸椎OPLLに対する手術成績の検討-後方進入前方除圧術と後方除圧術の比較-

小澤浩司, 衛藤俊光, 相澤俊峰, 菅野晴夫, 橋本功

脊柱靭帯骨化症に関する調査研究平成30年度総括・分担研究報告書(Web)　2019
Postoperative Changes in Presepsin Level and Values Predictive of Surgical Site Infection After Spinal Surgery: A Single-Center, Prospective Observational Study. International-journal

Tomoaki Koakutsu, Tetsuya Sato, Toshimi Aizawa, Eiji Itoi, Shigeki Kushimoto

Spine　43　(8)　578-584　2018/04/15

DOI： 10.1097/BRS.0000000000002376 　

ISSN： 0362-2436
胸椎後縦靱帯骨化症手術の多施設前向き研究術後運動麻痺リスク因子の解析

今釜史郎, 安藤圭, 竹内一裕, 加藤仁志, 相澤俊峰, 松山幸弘, 渡邉航太, 松本守雄, 吉井俊貴, 大川淳

日本整形外科学会雑誌　92　(2)　S124-S124　2018/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
プレセプシンの整形外科周術期における動態と基準値策定の試み単一施設前向き観察研究

小圷知明, 佐藤哲哉, 相澤俊峰, 井樋栄二, 久志本成樹

日本整形外科学会雑誌　92　(3)　S774-S774　2018/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
悪性腫瘍との鑑別が問題となった胸壁熱傷の1例

越智純子, 常陸真, 綿貫宗則, 保坂正美, 相澤俊峰, 渡辺みか

Japanese Journal of Radiology　36　(Supplement)　14　2018/02/25

ISSN： 1867-1071
脊髄係留症候群に対し一期的に脊髄係留解除術と脊柱短縮骨切り術を行った1例

藤井駿, 菅野晴夫, 相澤俊峰, 橋本功, 井樋栄二, 小澤浩司

東北整形災害外科学会プログラム・抄録集　115th　2018
胸腰椎部meningeal cystの手術治療

日下部隆, 中村豪, 関口玲, 衛藤俊光, 菅野晴夫, 橋本功, 相澤俊峰

東北整形災害外科学会雑誌　61　(1)　2018

ISSN： 1348-8694
術後評価 9)頚髄症における術後脊髄腫脹の検討-MRI Gd-DTPA増強効果との関係

小澤浩司, 相澤俊峰, 舘田聡, 橋本功, 菅野晴夫, 佐藤哲朗

整形外科　69　(6)　2018

ISSN： 0030-5901
Fluoroscopy-Guided Sacroiliac Intraarticular Injection via the Middle Portion of the Joint. International-journal

Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa

Pain medicine (Malden, Mass.)　18　(9)　1642-1648　2017/09/01
Publisher: Oxford University Press
DOI： 10.1093/pm/pnw297 　

ISSN： 1526-4637 1526-2375
成人脊柱変形の病態と治療後彎症患者はなぜ歩行中に体幹が傾くのか? 3次元動作解析による体幹-骨盤-下肢アライメントの検討

鎌田久美, 相澤俊峰, 井樋栄二, 小澤浩司, 関口雄介, 出江紳一

東北整形災害外科学会雑誌　60　(1)　176-176　2017/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
脊柱後弯症患者における歩行時の体幹前傾化の要因

鎌田久美, 小澤浩司, 関口雄介, 相澤俊峰, 出江紳一, 井樋栄二

日本整形外科学会雑誌　91　(2)　S158　2017/03/13

ISSN： 0021-5325
胸椎後縦靱帯骨化症手術における術後運動麻痺関連因子多施設前向き研究

今釜史郎, 安藤圭, 竹内一裕, 加藤仁志, 相澤俊峰, 松山幸弘, 渡邉航太, 松本守雄, 吉井俊貴, 大川淳, 厚労科研, AMED班研究胸椎AM, 手術多施設研究グループ

日本整形外科学会雑誌　91　(3)　S738-S738　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊柱靭帯骨化症に関する調査研究強直性脊椎病変の画像所見に関する研究

衛藤俊光, 相澤俊峰, 菅野晴夫, 橋本功, 小澤浩司

脊柱靭帯骨化症に関する調査研究平成28年度総括研究報告書(Web)　2017
整形外科周術期におけるmitochondrial DNAの動態

小圷知明, 山田充啓, 工藤大介, 桑原功行, 橋本功, 相澤俊峰, 井樋栄二, 久志本成樹

日本整形外科学会雑誌　90　(8)　S1717　2016/08/31

ISSN： 0021-5325
脊柱後彎症患者における歩行時の脊柱-骨盤-下肢関節アライメントの検討

鎌田久美, 小澤浩司, 関口雄介, 相澤俊峰, 出江紳一, 井樋栄二

日本整形外科学会雑誌　90　(8)　S1505-S1505　2016/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Lumbar artery injury from which the Adamkiewicz artery originated associated with lumbar spine injury: successfully treated by transcatheter arterial embolization. International-journal

Tomoaki Koakutsu, Toshimi Aizawa, Hironao Yuzawa, Eiji Itoi, Shigeki Kushimoto

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　25 Suppl 1　124-8　2016/05

DOI： 10.1007/s00586-015-4225-2 　

ISSN： 0940-6719
脊椎手術後のプレセプシン値の推移―術後創傷感染症早期診断における有用性―

小圷知明, 佐藤哲哉, 桑原功行, 工藤大介, 相澤俊峰, 橋本功, 井樋栄二, 久志本成樹

日本整形外科学会雑誌　90　(2)　S86　2016/03/04

ISSN： 0021-5325
Benign thoracic dumbbell tumor can be removed through hemilaminectomy and facetectomy without spinal reconstruction. International-journal

Toshimi Aizawa, Hiroshi Ozawa, Ko Hashimoto, Haruo Kanno, Shoichi Kokubun, Eiji Itoi

Journal of neurosurgical sciences　60　(1)　145-8　2016/03

ISSN： 0390-5616

eISSN： 1827-1855
腰部脊柱管狭窄症に対する内視鏡下椎弓切除術と棘突起縦割式椎弓切除術の前向き比較試験

山屋誠司, 中村聡, 千田香織, 菅野晴夫, 橋本功, 相澤俊峰, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　90　(3)　2016

ISSN： 0021-5325
脊柱後彎症における歩行時姿勢の検討

鎌田久美, 小澤浩司, 関口雄介, 相澤俊峰, 出江紳一, 井樋栄二

日本整形外科学会雑誌　89　(8)　S1637-S1637　2015/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
T1神経根症とその特徴的症候

田中靖久, 椿野巧, 星川健, 高橋康平, 鈴木学, 松田倫治, 橋本功, 菅野晴夫, 相澤俊峰

Journal of Spine Research　6　(3)　2015

ISSN： 1884-7137
Spino-pelvic alignment during walking in elderly patients with spinal kyphosis

鎌田久美, 小澤浩司, 関口雄介, 相澤俊峰, 出江紳一, 井樋栄二

運動器リハビリテーション = The journal of musculoskeletal medicine : 日本運動器科学会誌　26　(4)　414-418　2015
Publisher: 日本運動器科学会
ISSN： 2187-8420
動脈塞栓術が奏効した仙骨骨巨細胞腫の2例

常陸真, 高橋昭喜, 綿貫宗則, 保坂正美, 相澤俊峰, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　88　(6)　S1280-S1280　2014/06
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
最近10年間の当科におけるLuque SSI法の経験

吉田新一郎, 小澤浩司, 相澤俊峰, 中村豪, 菅野晴夫, 小圷知明, 井樋栄二

東北整形災害外科学会雑誌　57　(1)　15-19　2014/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
自家骨移植により骨欠損部を再建し人工膝関節置換術を行ったCharcot関節の1例

佐々木毅志, 杉田健彦, 佐々木啓, 前田郁雄, 本間哲夫, 大沼正宏, 相沢俊峰, 柏葉光宏, 高橋敦, 藤澤博一, 上村雅之

東北整形災害外科学会雑誌　57　(1)　133-136　2014/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
頚椎椎間板ヘルニアに対する脊柱管拡大術の長期成績-多施設前向き研究による前方除圧固定術との比較-

小圷知明, 佐々木盛力, 両角直樹, 石井祐信, 国分正一, 関口玲, 橋本功, 相澤俊峰, 井樋栄二, 笠間史夫, 田中靖久, 佐藤哲朗, 山崎伸

Journal of Spine Research　5　(3)　2014

ISSN： 1884-7137
脊柱後弯症に対する短期集中型のリハビリテーション訓練の効果について-介入の前後を比較した予備的研究-

関口雄介, 関口雄介, 小澤浩司, 金子雅明, 相澤俊峰, 橋本功, 菅野晴夫, 出江紳一, 井樋栄二

運動器リハビリテーション　25　(2)　2014

ISSN： 2187-8420
腰部脊柱管狭窄症における荷重MRIと脊髄造影の比較

菅野晴夫, 遠藤俊毅, 小澤浩司, 相澤俊峰, 古泉豊, 両角直樹, 石井祐信, 井樋栄二

Journal of Spine Research　3　(3)　215-215　2012/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137
【炎症など悪性骨・軟部腫瘍と見まちがう疾患-診断のポイント】骨組織球症臨床・画像上の特徴と悪性腫瘍との鑑別

保坂正美, 羽鳥正仁, 常陸真, 綿貫宗則, 相沢俊峰, 井樋栄二

整形・災害外科　54　(10)　1159-1170　2011/09
Publisher: 金原出版(株)
ISSN： 0387-4095
Causes of poor out-come of plate fixation for the mid-shaft clavicle fractures

MINETA M., AIZAWA T., SASAJIMA K., HATTA T.

32　(1)　77-79　2010/02/25

ISSN： 0287-2285
責任高位による胸部脊髄症の診断の問題点上位と下位罹患例の診断過程の比較

中村豪, 相澤俊峰, 小澤浩司, 日下部隆, 井樋栄二

Journal of Spine Research　1　(4)　1014-1014　2010
宮城県住民における腰椎椎間板ヘルニア手術の疫学調査

日下部隆, 小澤浩司, 相澤俊峰, 小川真司, 松本不二夫, 村上栄一, 笠間史夫, 田中靖久, 石井祐信, 佐藤哲朗, 井樋栄二, 国分正一

Journal of Spine Research　1　(4)　827-827　2010
骨粗鬆性椎体骨折偽関節に対する椎弓根スクリューとフックを併用した脊柱短縮術

小澤浩司, 田中靖久, 星川健, 相澤俊峰, 日下部隆, 中村豪, 井樋栄二, 国分正一

Journal of Spine Research　1　(3)　290-290　2010
脂肪髄膜瘤による脊髄係留症候群に対する脊柱短縮骨切り術の手術成績

相澤俊峰, 小澤浩司, 日下部隆, 中村豪, 井樋栄二, 星川健, 田中靖久, 国分正一

日本整形外科学会雑誌　84　(4)　S671-S671　2010
仙骨前面巨大神経鞘腫の治療

小澤浩司, 相澤俊峰, 日下部隆, 中村豪, 井樋栄二

日本整形外科学会雑誌　84　(4)　S420-S420　2010
脊髄髄膜腫の臨床症状、手術成績について神経鞘腫との比較

中村豪, 小澤浩司, 相澤俊峰, 日下部隆, 井樋栄二

日本整形外科学会雑誌　84　(4)　S418-S418　2010
特発性胸髄硬膜外脂肪腫の1例

篠崎晋久, 小津浩司, 相澤俊峰, 星川健, 川原央, 千葉大介, 井樋栄二

東北整形災害外科学会雑誌　53　(1)　188-189　2009/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
両下肢麻痺で発症したdumbbell型ユーイング肉腫ファミリー腫瘍(ESFT)の1例

森谷邦彦, 熊谷直憲, 松本幸子, 新妻秀剛, 小沼正栄, 力石健, 笹原洋二, 久間木悟, 土屋滋, 相沢俊峰, 保坂正美

日本小児科学会雑誌　113　(4)　751-751　2009/04
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
脊髄神経鞘腫の臨床症状、手術成績について

小澤浩司, 相澤俊峰, 星川健, 日下部隆, 井樋栄二

日本脊椎脊髄病学会雑誌　20　(2)　577-577　2009
胸椎連続型OPLLに対する後方除圧術の限界

小澤浩司, 武井寛, 伊藤拓緯, 相澤俊峰, 星川健, 日下部隆, 菅野晴夫, 石井祐信, 佐藤哲朗, 井樋栄二

日本脊椎脊髄病学会雑誌　20　(2)　370-370　2009
【変性腰椎の治療戦略】変性腰椎(脊柱管狭窄症)の画像診断腰部脊柱管狭窄症の荷重MRI

菅野晴夫, 小澤浩司, 相澤俊峰, 星川健, 日下部隆, 井樋栄二, 石井祐信, 国分正一

関節外科　28　(5)　580-587　2009
原発性骨盤腫瘍に対し動脈塞栓術とビスフォスフォネート製剤を用いた治療経験

保坂正美, 羽鳥正仁, 綿貫宗則, 星川健, 相澤俊峰, 日下部隆, 小澤浩司, 井樋栄二

日本整形外科学会雑誌　83　(6)　S864-S864　2009
腰部脊柱管狭窄症における荷重MRIの検討

菅野晴夫, 小澤浩司, 相澤俊峰, 星川健, 川原央, 井樋栄二

東北整形災害外科学会雑誌　53　(1)　237-237　2009
銃弾による胸髄損傷の1例

星川健, 千葉大介, 菅野晴夫, 橋本功, 川原央, 相澤俊峰, 小澤浩司

東北整形災害外科学会雑誌　53　(1)　232-232　2009
環軸関節回旋により脊髄圧迫が生じた脊髄砂時計腫 2例報告

日下部隆, 小澤浩司, 相澤俊峰, 星川健, 中村豪, 石井祐信, 井樋栄二

東日本整形災害外科学会雑誌　21　(3)　386-386　2009
前仙骨シュワン腫の外科的治療 5症例報告

PongsthornChanplakorn, 小澤浩司, 相澤俊峰, 日下部隆, 中村豪, 井樋栄二

東日本整形災害外科学会雑誌　21　(3)　282-282　2009
頭痛を契機に発見されたC1/C2椎間関節嚢腫の1例

中嶋信人, 野本達也, 水越元気, 上田雅之, 橋本功, 相澤俊峰, 小澤浩司, 永山寛, 山崎峰雄, 片山泰朗

日本頭痛学会誌　35　(2)　79-79　2008/11
Publisher: (一社)日本頭痛学会
ISSN： 1345-6547
両下肢麻痺で発症したdumbbell型ユーイング肉腫ファミリー腫瘍(ESFT)の1例

森谷邦彦, 熊谷直憲, 松本幸子, 新妻秀剛, 小沼正栄, 力石健, 笹原洋二, 久間木悟, 土谷滋, 相沢俊峰, 保坂正美

小児がん　45　(プログラム・総会号)　318-318　2008/11
Publisher: (NPO)日本小児がん学会
ISSN： 0389-4525
Axially loaded magnetic resonance image in patients with lumbar spinal canal stenosis

KANNO H.

19　(2)　415-415　2008/03/20

ISSN： 1346-4876
Intramedullary enhanced lesion in MRI of cervical myelopathy

OZAWA H.

19　(1)　26-26　2008/03/20

ISSN： 1346-4876
脊椎内視鏡下手術の現状ー2006年1月〜12月手術施行状況調査・インシデント報告集計結果ー (日整会誌)

長谷川徹, 相澤俊峰, 猪川輪哉, 伊東学, 江原宗平, 岡治道, 加藤真介, 加藤圭彦, 川上守, 川原範夫, 古賀公明, 紺野慎一, 坂本直俊, 佐藤公治, 佐藤公昭, 高野裕一, 高橋誠, 田中雅人, 出沢明, 中野恵介, 中村博亮, 夏山元伸, 長谷川和宏, 蜂谷裕道, 平泉裕, 藤本吉範, 前川慎吾, 前田健, 松本守雄, 三上靖夫, 望月眞人, 八木省次, 山縣正庸, 山元拓哉, 湯澤洋平, 吉田宗人, 四宮謙一, 戸山芳昭

日整会誌　81　1072-1077　2007/12
Estrogen deficiency leads to decrease in chondrocyte numbers in the rabbit growth plate

81　(9)　732-732　2007/09/25

ISSN： 0021-5325
Effect of periarticular and intraarticular lidocaine injections for sacroilian joint pain : prospective comparative study

81　(7)　601-601　2007/07/25

ISSN： 0021-5325
黄色靱帯骨化. (脊椎脊髄ジャーナル)

相澤俊峰, 田中靖久, 星川健, 小澤浩司, 川原央, 井樋栄二

脊椎脊髄ジャーナル　20　117-124　2007/05
脊椎類骨骨腫に伴う側彎の本態傍脊柱筋の筋融解

川原央, 小澤浩司, 田中靖久, 相沢俊峰, 星川健, 石井祐信, 佐藤哲朗, 国分正一

日本脊椎脊髄病学会雑誌　18　(1)　62-62　2007/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1346-4876
En bloc Excision of Thoracic Chondrosarcoma by Partial Vertebrectomy

OZAWA H.

17　(1)　243-243　2006/03/20

ISSN： 1346-4876
特発性脊髄ヘルニアの神経症候. (脊椎脊髄ジャーナル)

相澤俊峰, 田中靖久, 国分正一

脊椎脊髄ジャーナル　18　535-539　2005/10
頚椎前方除圧固定術（ASF）のクリティカルパス. (整形災害外科)

相澤俊峰, 富谷明人, 国分正一, 菅野知恵, 小綿瑞恵

整形災害外科　47　553-561　2004/10
【内分泌病理学最近の進歩 2003】終糸発生傍神経節腫の1例 (ホルモンと臨床)

渡辺みか, 森谷卓也, 笹野公伸, 相澤俊峰

ホルモンと臨床　51　(臨増)　158-161　2003/08
Spinal eosinophilic granulomas follwed by magnetic resonance imaging

AIZAWA T.

14　(1)　390-390　2003/02/20

ISSN： 1346-4876
Cervical radiculopathy causing drop finger

TANAKA Y.

14　(1)　345-345　2003/02/20

ISSN： 1346-4876
運動負荷と骨格筋細胞のIL-6

富山明人, 相澤俊峰, 川又朋麿, 国分正一, 永富良一, 泉水宏臣

日本整形外科学会雑誌　76　(8)　S957-S957　2002/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
第1肋骨に発生し脊椎に浸潤した骨巨細胞腫の1手術例

樋口和東, 田中靖久, 星川健, 相沢俊峰, 両角直樹, 後藤均, 佐藤哲朗, 国分正一

東北整形災害外科紀要　46　(1)　132-132　2002/06
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
Idiopathic herniation of the thoracic spinal cord

AIZAWA T.

13　(1)　53-53　2002/04/26

ISSN： 1346-4876
第1肋骨に発生し脊椎に浸潤した骨巨細胞腫の1手術例

樋口和東, 田中靖久, 星川健, 相沢俊峰, 両角直樹, 佐藤哲朗, 国分正一

日本脊椎脊髄病学会雑誌　13　(1)　63-63　2002/04
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1346-4876
Expression of IL-6 in Skeletal Muscle after Eccentric Exercise

TOMIYA Akihito, 相澤俊峰, 川又朋麿, 国分正一, 永富良一, 泉水宏臣, 上住聡芳

日本整形外科スポーツ医学会雑誌 = Japanese journal of orthopaedic sports medicine　22　(1)　86-86　2002/02/28

ISSN： 1340-8577
【頸椎後彎症】先天性頸椎後彎症

国分正一, 田中靖久, 小澤浩司, 相澤俊峰, 佐藤哲朗, 石井祐信

脊椎脊髄ジャーナル　14　(1)　16-21　2001
【脊椎外科最近の進歩】髄内腫瘍の診断と摘出術における課題

佐藤哲朗, 田中靖久, 小澤浩司, 相澤俊峰, 国分正一

臨床整形外科　36　(4)　379-385　2001

DOI： 10.11477/mf.1408903245 　
【小児整形外科最近の動向】小児脊髄腫瘍と片側望椎弓切除による摘出術

国分正一, 佐藤哲朗, 田中靖久, 小澤浩司, 相澤俊峰

整形・災害外科　44　(9)　1101-1109　2001
多数回手術を要した多発性脊柱靱帯骨化症の1例

中條悟, 佐藤哲朗, 田中靖久, 小澤浩司, 後藤均, 相沢俊峰, 石塚正人, 綿貫宗則, 国分正一

東北整形災害外科紀要　44　(2)　259-259　2000/12
Publisher: 東北整形災害外科学会
ISSN： 0040-8751
Chondrocyte Apoptosis during Endochondral Fracture Healing

AIZAWA T., GERSTENFELD LC., EINHORN TA.

74　(8)　S1724　2000/08/25

ISSN： 0021-5325
The problems of diagnosis and extirpation of intramedullary spinal cord tumors

SATO T.

11　(1)　3-3　2000/04/28

ISSN： 0915-6496
Wedge osteotomy through posterior approach for lumbar degenerative kyphosis : evolution of operative technique and results

KOKUBUN S.

9　(1)　29-29　1998/05/22

ISSN： 0915-6496
【黄色靱帯骨化症】胸椎部黄色靱帯骨化症の手術法と合併症

佐藤哲朗, 田中靖久, 相沢俊峰

脊椎脊髄ジャーナル　11　(5)　505-510　1998/05
Publisher: (株)三輪書店
ISSN： 0914-4412
Localization and Roles of Apoptosis-related Proteins in Growth Plate

AIZAWA T., ROACH H. I.

71　(8)　S1583　1997/08/25

ISSN： 0021-5325
Expression of Fas Antigen, Osteonectin and Osteocalcin in Rabbit Growth Plate Chondrocytes

AIZAWA T.

70　(8)　S1528　1996/08/25

ISSN： 0021-5325
Expression of PCNA and Apoptosis in Rabbit Growth Plate Chondrocytes

AIZAWA T.

69　(8)　S1554　1995/08/25

ISSN： 0021-5325
第6頸椎分離症の1例

相沢俊峰, 神尾一彦, 鈴木寛

東北整形災害外科紀要　37　(1)　21-23　1993/05
Publisher: 東北整形災害外科学会
ISSN： 0040-8751

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Books and Other Publications 4

スキル関節鏡下手術アトラス脊椎内視鏡下手術.

相澤俊峰

2013/04/01
アトラス骨・関節画像診断. 5. 脊椎・脊髄

山下敏彦, 相澤俊峰, 小澤浩司

中外医学社　2011/07
最新整形外科学大系第１巻運動器の生物学と生体力学

越智隆弘, 相澤俊峰, 杉田健彦

中山書店　2008/09
Ossification of the Posterior Longitudinal Ligament

Tanaka Y, Sato, T, Aizawa T

Springer　2006/10

Presentations 16

最近の大学病院における化膿性脊椎炎の臨床症状、画像所見の特徴

日整会学術総会　2013/05/23
腰部脊柱管狭窄症に対する開窓術後再手術例の検討

日本脊椎脊髄病学会　2013/04/25
Thoracic myelopathy in Japan International-presentation

Annual meeting of Taiwan Spine Society　2013/03/21
生存解析を用いた腰椎椎間板ヘルニア再発手術率の検討.

相澤俊峰ほか

日本脊椎脊髄病学会　2012/04/19
腰椎椎間板ヘルニア再発手術例の疫学的検討

相澤俊峰ほか

日本整形外科学会総会　2011/05/15
合併症による腰椎再手術：東北大学脊椎外科懇話会手術登録14046手術の検討.

相澤俊峰ほか

日本脊椎脊髄病学会　2011/04/20
脂肪髄膜瘤による脊髄係留症候群に対する脊柱短縮骨切り術の手術成績

相澤俊峰, 小澤浩司, 日下部隆, 中村豪, 国分正一, 田中靖久, 井樋栄二

日本整形外科学会総会　2010/05/17
10. Spine-shortening Vertebral Osteotomy for the Patients with Tethered Cord Syndrome Caused by Spinal Lipoma. International-presentation

Aizawa T, Kokubun S, Ozawa H, Kusakabe T, Itoi E

European Federation of National Associations of Orthopaedics and Traumatology,　2009/06/03
成人では胸髄症に対する椎弓切除術後に局所後弯がどれくらい進行するか

相澤俊峰, 佐藤哲朗, 小澤浩司, 星川健, 松本不二夫, 国分正一

第81回日整会学術総会　2008/05/22
胸部脊髄症134例の手術成績の検討

相澤俊峰, 佐藤哲朗, 佐々木祐肇, 松本不二夫, 両角直樹, 日下部隆, 川原央, 星川健, 小澤浩司, 田中靖久, 国分正一

日本脊椎脊髄病学会　2007/04/26
Results of surgery for thoracic myelopathy International-presentation

Aizawa T, Sato T

American Academy of Orthopaedic Surgeons　2007/02/14
脊柱靱帯骨化症による脊髄症手術症例の疫学的研究

相澤俊峰, 田中靖久, 小澤浩司ほか

日本整形外科学会総会　2006/04/20
Analysis of 139 patients with thoracic myelopathy caused by ossification of the ligamentum flavum. International-presentation

Aizawa T, Sato T, Kokubun S, Kusakabe T, Morozumi K

American Academy of Orthopaedic Surgeons　2006/03/22
5. Analysis of 139 patients with thoracic myelopathy caused by ossification of the ligamentum flavum. International-presentation

Aizawa T, Sato T

American Academy of Orthopaedic Surgeons　2006/03/22
Ananysis of 139 patients with thoracic myelopathy caused by ossofocatoin of the ligamentum flavum International-presentation

Aizawa T, Sato T

American Academy of Orthopaedic Surgeons　2006/03/22
Analysis of 139 patients with thoracic myelopathy caused by ossification of the ligamentum flavum International-presentation

Aizawa T, Sato T

American Academy of Orthopaedic Surgeons　2006/03/22

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Research Projects 3

胸椎後縦靭帯骨化症による脊髄圧迫障害を脊髄内応力マッピングで可視化・定量化する

高橋康平, 橋本功, 相澤俊峰, 大野木孝嘉

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2023/04/01 - 2026/03/31

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先行研究として行っていた胸椎後縦靭帯骨化症に対する新しい術式である後方進入前方除圧術の手術成績の論文「Anterior shift of the ventral dura mater: A novel concept of the posterior surgery for ossification of the posterior longitudinal ligament in thoracic spine」が2023年4月にFrontiers in Surgeryに採択された。また、2023年に行われた日本脊椎脊髄病学会（札幌）、Eurospine(フランクフルト)で胸椎後縦靭帯骨化症に関する研究の報告を行った。これらの報告では、胸椎後縦靭帯の画像上の重症度と手術成績などの関連を報告している。有限要素法による応力解析を行うために十分な機能を有するパソコンを購入し、のソフトウェアをインストールした。解析するためのプログラミングを、東京都立大学工学部の坂元氏に依頼している。解析するための症例はすでに蓄積されており、画像上の計測（骨化後弯角、脊柱占拠率、OPLLの形態の解析）をおこなった。臨床症状と比較し、責任椎間を同定した。ソフトウェアが使用可能になった時点で、脊髄応力解析を開始し、画像上の計測値や臨床症状との関連を調べる計画となっている。9月頃から画像の解析に着手する予定としている。
The effects of sex hormone on growth plate chondrocyte.

YAMADA Norikazu, OONUMA Masahiro, KAWAMATA Tomomaro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2002 - 2004

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Sex hormones play important roles in the regulation of chondrocyte proliferation, maturation and death in epiphyseal growth plate. We investigated the effects of male castration on the cell kinetics of chondrocytes, defined by the numbers of proliferating and dying cells. The growth plates of normal rabbits and castrated at 8 weeks of age were obtained at 10, 15, 20 and 25 weeks old. They were stained for apoptotic and proliferating chondrocytes using immunostaining for caspase-3 and PCNA. The castrated rabbits showed higher caspase-3-positive and lower PCNA-positive ratios than the corresponding normal groups. In addition, the number of chondrocytes in the castrated rabbits was less than that of the normal ones at the same age. Our study suggested that castration led an increase of apoptosis and decrease of proliferating ability in growth plate chondrocytes. Then, we cultured chondrocytes to investigate the effects of sex hormone on chondrocytes in vitro. 17-day-old fatal chick sterno was obtained and revealed by H-E stain to be composed of hypertrophic chondrocytes in 1/4 of cranial side and premature chondrocytes in 1/2 of caudal side. We obtained 5mm cranial and 8mm caudal side of sterno and cultivate them according to Gerstenfeld's method. The RNA of the cultured chondrocytes was extracted and reversetranscription-polymerase chain reaction (RT-PCR) was performed. The cranial chondrocytes presented type 10 collagen and the caudal ones type 2 collagen. That indicated that the former is mature hypertrophic chondrocyte and the latter premature chondrocyte. Sex hormone load test was performed with the culture system. Testosterone and estrogen at 10-10,10-9,10-8,10-7,10-6mol/l were added in hypertrophic and premature chondrocyte. The ALP activity, proliferative activity, cell death, mRNA of type 2 and 10 collage were tested. Testosterone stimulated cell proliferation, and estrogen stimulated cell death.
Effect of Tumor Necrosis Factor to Chondrocytes in Endochondral Ossification

AIZAWA Toshimi, OONUMA Masahiro, KAWAMATA Tomomaro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2000 - 2001

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In endochondral ossification, chondrocytes change their morphology and functions and are ultimately removed by the process of programmed cell death (apoptosis). A variety of apoptosis inducing signals and death factors have been characterized including tumor necrosis factor-alpha (TNF-α), Fas ligand (FasL) and TNF-related apoptosis-inducing ligand (TRAIL). However, there is little known regarding the activity of these factors in the process of fracture healing. Using RNase protection assay (RPA) and immunohistochemistry, this study sought to determine if these factors might participate in endochondral fracture healing. A closed, transverse fracture was made in the right tibiae of 8-10 week old BALB/C mice. Mice were euthanized at 1, 2 and 3 weeks post-fracture. The tibiae were harvested and studied for the expression of caspase-8, a key enzyme of apoptosis. TNF-α, FasL and TRAIL, were assayed using RPA for mRNA and immunostaining for protein. At each time point, caspase-8, FasL and its receptor Fas receptor (FasR), TNF-α and its receptor p55, and TRAIL were detected by RPA. Immunostainings clearly showed that caspase-8, TNF-α, FasL, FasR and TRAIL were expressed in fracture callus chondrocytes. Additionally, the mice in which TNF-α receptors were ablated showed very little expression of caspase-8 by RPA. These findings suggest that cartilaginous callus is replaced by new bone during endochondral fracture healing and chondrocyte removal by apoptosis is controlled by several death factors via autocrine and paracrine mechanisms, particularly TNF-α might play a major role in chondrocyte death.

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急性脊髄損傷に対する顆粒球コロニー刺激因子を用いた神経保護療法

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急性脊髄損傷に対する顆粒球コロニー刺激因子を用いた神経保護療法
大学病院における化膿性脊椎炎の最近の動向

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大学病院における化膿性脊椎炎の最近の動向