研究者詳細

顔写真

ミヤタ　トシオ
宮田　敏男
Toshio Miyata
所属
大学院医学系研究科　創生応用医学研究センター　分子病態治療学分野
職名
教授
学位

  • 医学博士（名古屋大学）

経歴 26

  • 1994年5月 ～ 1997年2月
    名古屋大学医学部附属病院分院内科 講師

  • 1994年 ～ 1997年
    Associate Professor, Department of Internal

  • 1990年6月 ～ 1994年5月
    大阪大学微生物病研究所難治疾患バイオ分析部門

  • 1990年 ～ 1994年
    Assistant Professor, Department of

  • 1990年4月 ～ 1991年6月
    日本学術振興会 特別研究員

  • 1990年 ～ 1991年
    Fellowships of the Japan Society for the

  • 1986年4月 ～ 1987年3月
    社会保険中京病院 研修医勤務

  • 1986年 ～ 1987年
    Resident at Shakai-Hoken Chuyou Hospital,

  • 2000年4月 ～
    東海大学医学部内科 助教授

  • 1999年4月 ～
    東海大学総合医学研究所分子病態学部門・医学部

  • 1997年3月 ～
    東海大学総合医学研究所分子病態学部門・医学部

  • 内科 助教授

  • 内科 講師

  • 免疫不全疾患研究分野 助手

  • Nagoya, Japan

  • Scientists

  • Promotion of Science for Japanese Junior

  • Osaka, Japan

  • Microbial Diseases, Osaka University, Suita,

  • Immunoregulation, Research Institute for

  • University School of Medicine, Nagoya, Japan

  • Medicine, The Branch Hospital, Nagoya

  • Isehara Kanagawa 259-1193, Japan

  • Tokai University School of Medicine, Bohseidai,

  • Medicine

  • At Present Associate Professor, Department of Internal

︎全件表示 ︎最初の5件までを表示

学歴 4

  • 名古屋大学医学部医学研究科大学院　医学研究科

    ～ 1990年

  • University of Nagoya, School of Medicine　Graduate School, Division of Medicine

    ～ 1990年

  • 名古屋大学　医学部

    ～ 1986年

  • University of Nagoya　Faculty of Medicine

    ～ 1986年

委員歴 19

  • Aging Science Forum　Member of Council

    2000年 ～

  • The Japanese Society of Pathophysiological & Therapeutic Research in Renal Failure　Member of Council

    2000年 ～

  • Cardiovascular Research Forum　Member of Council

    1998年 ～

  • The Japanese Society of Molecular Medicine　Member of Council

    1998年 ～

  • The Japan Society of Nephrology　Member of Council

    1989年 ～

  • アメリカ腎臓学会　会員

  • 日本糖尿病学会　会員

  • 分子腎臓研究会　幹事

  • Cardiovascular Research Forum　世話人

  • 腎不全病態治療研究会　世話人

  • Aging Science Forum　世話人

  • Asian Integrated Nephrology Forum 企画委員会　委員

  • 骨細胞分子研究会　評議員

  • 日本臨床分子医学会　評議員

  • 日本内科学会　会員

  • 日本透析医学会　会員

  • 日本腎臓学会　評議員

  • 国際腎臓学会　会員

  • Nephrology Dialysis Transplantation　Editorial Board

︎全件表示 ︎最初の5件までを表示

所属学協会 24

  • アメリカ腎臓学会

  • 日本糖尿病学会

  • 分子腎臓研究会

  • Cardiovascular Research Forum

  • 腎不全病態治療研究会

  • Aging Science Forum

  • Asian Integrated Nephrology Forum 企画委員会

  • 骨細胞分子研究会

  • 日本臨床分子医学会

  • 日本内科学会

  • 日本透析医学会

  • 日本腎臓学会

  • 国際腎臓学会

  • Nephrology Dialysis Transplantation

  • Cardiovascular Research Forum

  • Aging Science Forum

  • The Japanese Society of Pathophysiological & Therapeutic Research in Renal Failure

  • The Japanese Society of Molecular Medicine

  • The Japanese Society of Diabetes

  • The American Society of Nephrology

  • The Japanese Society of Internal Medicine

  • The Japanese Society for Dialysis Therapy

  • The Japan Society of Nephrology

  • The International Society of Nephrology

︎全件表示 ︎最初の5件までを表示

研究キーワード 6

  • エージーイーエス

  • メグシン

  • カルボニルストレス

  • AGES

  • Megsin

  • Carbonyl stress

研究分野 1

  • ライフサイエンス / 腎臓内科学 /

受賞 8

  1. 日本臨床分子医学会学術奨励賞

    2002年

  2. The Japanese Society of Molecular Medicine Award

    2002年

  3. 財団法人長寿科学振興財団奨励賞

    2001年

  4. Japan Foundation for Aging and Health Award

    2001年

  5. 日本腎臓学会大島賞

    1995年

  6. Oshima Award of the Japanese Society of Nephrology

    1995年

  7. 日本内科学会奨励賞

    1993年

  8. Young Investigator Award of the Japanese Society of Internal Medicine

    1993年

︎全件表示 ︎最初の5件までを表示

MISC 122

  1. Clusterin is up-regulated in glomerular mesangial cells in complement-mediated injury

    K Yamada, Y Hori, N Hanafusa, T Okuda, N Nagano, NH Choi-Miura, WG Couser, T Miyata, K Kurokawa, T Fujita, M Nangaku

    KIDNEY INTERNATIONAL　59　(1)　137-146　2001年1月

    DOI： 10.1046/j.1523-1755.2001.00474.x 　

    ISSN： 0085-2538

  2. Alterations in nonenzymatic biochemistry of carbohydrates and lipids in uremia.

    Massry and Glassock's Text book of Nephrology　68　(1275-1278)　2001年

  3. Reactive carbonyl compound-related uremic toxicity(carbonyl stress).

    Kidney Int　(59Suppl 78)　25-31　2001年

  4. Does removal of glucose lower the carbonyl stress of glucose containing peritoneal dialysis? : effect of dwell time on icodextrin and amino acid PD fluids.

    Kidney Int　(58)　2518-2524　2001年

    DOI： 10.1046/j.1523-1755.2000.00436.x 　

  5. Neuronal and glial advanced glycation end poduct[Nε-(carboxymethyl)lysine]in Alzheimer's disease brains.

    Acta Neuropathol　(101)　27-35　2001年

  6. Advanced glycation and lipoxidation end products: reactive carbonyl compounds-related uraemic toxicity

    T Miyata, A Saito, K Kurokawa, CV de Strihou

    NEPHROLOGY DIALYSIS TRANSPLANTATION　16　(16Suppl 4)　8-11　2001年

    ISSN： 0931-0509

  7. Reactive carbonyl compounds as uremic toxins.

    Contrib Nephrol　(133)　71-80　2001年

  8. b2-Microglobulin modified with advanced glycation end products delays monocyte apoptosis and induces differenciation into macrophage-like cells.

    Kidney Int　(59)　990-1002　2001年

    DOI： 10.1046/j.1523-1755.2001.059003990.x 　

  9. Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis

    S Combet, T Miyata, P Moulin, D Pouthier, E Goffin, O Devuyst

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　11　(4)　717-728　2000年4月

    ISSN： 1046-6673

  10. Nitric oxide inhibits the formation of advanced glycation and products.

    Kidney Int　(58)　1780-1787　2000年

    DOI： 10.1046/j.1523-1755.2000.00340.x 　

  11. Induction of apoptosis by glyoxal in human embryonic lung epithelial cell line L132.

    Am J Respi Cell Mol Biol　(487-491)　23　2000年

  12. Advanced glycation and lipoxidation of the peritoneal membrane : Respective roles of serum and peritoneal fluid reactive carbonyl compounds.

    Kidney Int　58　(425-435)　2000年

    DOI： 10.1046/j.1523-1755.2000.00182.x 　

  13. Advanced glycation and lipoxidation end products : Role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism.

    J Am Soc Nephrol　11　(1744-1752)　2000年

  14. 4-Hydroxynonenal induces a cellular redox-related activation of the caspase. cascade for apoptotic cell death

    J Cell Sci　113　(635-641)　2000年

  15. 'Carbonyl stress' and dialysis-related amyloidosis

    T Miyata, Y Ueda, A Saito, K Kurokawa

    NEPHROLOGY DIALYSIS TRANSPLANTATION　15　(Suppl. 1)　25-28　2000年

    ISSN： 0931-0509

  16. Methylglyoxal induces apoptosis in jurkat leukemia T-cells by activating c-Jun N-terminal kinase.

    J Cell Biochem　77　(2)　333-344　2000年

    DOI： 10.1002/(SICI)1097-4644(20000501)77:2<333::AID-JCB15>3.0.CO;2-Q 　

    ISSN： 0730-2312

  17. Mechanism of inhibitory effect of OPB-9195[(±)2-isopropylidenehydrazono-4-oxothiazolidin-5ylacetanilide]on AGE and ALE formation. Advanced lipoxidation end product formation.

    J Am Soc Nephrol　11　(1719-1725)　2000年

  18. Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction

    N Kawada, T Moriyama, A Ando, M Fukunaga, T Miyata, K Kurokawa, E Imai, M Hori

    KIDNEY INTERNATIONAL　56　(3)　1004-1013　1999年9月

    DOI： 10.1046/j.1523-1755.1999.00612.x 　

    ISSN： 0085-2538

  19. 4-hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition

    W Liu, AA Akhand, M Kato, Yokoyama, I, T Miyata, K Kurokawa, K Uchida, Nakashima, I

    JOURNAL OF CELL SCIENCE　112　(14)　2409-2417　1999年7月

    ISSN： 0021-9533

  20. Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney

    T Miyata, S Sugiyama, M Nangaku, D Suzuki, KI Uragami, R Inagi, H Sakai, K Kurokawa

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　10　(7)　1590-1595　1999年7月

    ISSN： 1046-6673

  21. Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: Synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases

    S Kikuchi, K Shinpo, F Moriwaka, Z Makita, T Miyata, K Tashiro

    JOURNAL OF NEUROSCIENCE RESEARCH　57　(2)　280-289　1999年7月

    DOI： 10.1002/(SICI)1097-4547(19990715)57:2<280::AID-JNR14>3.0.CO;2-U 　

    ISSN： 0360-4012

  22. Decrease in serum pentosidine levels of ESRD patients during polysulfone haemodialysis

    G Stein, S Franke, H Sperschneider, J Vienken, Y Ueda, T Miyata, K Kurokawa

    NEPHROLOGY DIALYSIS TRANSPLANTATION　14　(6)　1606-1608　1999年6月

    DOI： 10.1093/ndt/14.6.1606 　

    ISSN： 0931-0509

  23. Influence of hemodialysis membrane type on pentosidine plasma level, a marker of "carbonyl stress"

    M Jadoul, Y Ueda, Y Yasuda, A Saito, A Robert, N Ishida, K Kurokawa, CV de Strihou, T Miyata

    KIDNEY INTERNATIONAL　55　(6)　2487-2492　1999年6月

    DOI： 10.1046/j.1523-1755.1999.00468.x 　

    ISSN： 0085-2538

  24. Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions

    D Suzuki, T Miyata, N Saotome, K Horie, R Inagi, Y Yasuda, K Uchida, Y Izuhara, M Yagame, H Sakai, K Kurokawa

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　10　(4)　822-832　1999年4月

    ISSN： 1046-6673

  25. A sensitive and specific ELISA for plasma pentosidine

    Y Izuhara, T Miyata, Y Ueda, D Suzuki, K Asahi, R Inagi, H Sakai, K Kurokawa

    NEPHROLOGY DIALYSIS TRANSPLANTATION　14　(3)　576-580　1999年3月

    ISSN： 0931-0509

  26. Increase in the advanced glycation end product pentosidine in Bruch's membrane with age

    JT Handa, N Verzijl, H Matsunaga, A Aotaki-Keen, GA Lutty, JMT Koppele, T Miyata, LM Hjelmeland

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　40　(3)　775-779　1999年3月

    ISSN： 0146-0404

  27. Possible involvement of"carbonyl stress"in the pathogenesis of dialysis-related amyloidosis.

    Am J Med Sci　317　410-415　1999年

  28. Nitric oxide controles src kinase activity through a sulfhydryl group modification mediated Tyr-527-independent and Try-416-linked mechanism.

    J Biol Chem　274　(36)　25821-25826　1999年

    DOI： 10.1074/jbc.274.36.25821 　

    ISSN： 0021-9258

  29. Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy.

    Kidney Int　56　(71)　S54-56　1999年

  30. Carbonyl stress : Increased carbonyl modification of tissue and cellular proteins in uremia.

    Perit Dial Int　19　(Supple 2)　58-61　1999年

  31. Oxdative stress-induced "Carbonylstress" in uremia.

    Redox Regulation of Cell Signaling and Its Clinical Application.　215-224　1999年

  32. Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src

    Anwarul A. Akhand, Masashi Kato, Haruhiko Suzuki, Wei Liu, Jun Du, Michinari Hamaguchi, Toshio Miyata, Kiyoshi Kurokawa, Izumi Nakashima

    Journal of Cellular Biochemistry　72　(1)　1-7　1999年1月1日

    出版者・発行元： Wiley-Liss Inc.

    DOI： 10.1002/(SICI)1097-4644(19990101)72:1<1::AID-JCB1>3.0.CO;2-Y 　

    ISSN： 0730-2312

  33. Carbonyl stress and diabetic nephropathy.

    Daisuke SUZUKI, Toshio MIYATA

    Internal Medicine　38　(4)　309-314　1999年

    DOI： 10.2169/internalmedicine.38.309 　

    ISSN： 0918-2918 1349-7235

  34. Glucose degradation product methylglyoxal enhances the production of vascular endothelial growth factor in peritoneal cells : Role in the functional and morphological alterations of peritoneal membrane dysfunction in peritoneal dialysis.

    FEBS Letter　463　(260-264)　1999年

    DOI： 10.1016/S0014-5793(99)01642-7 　

  35. Oxidative protein damage with carbohydrates and lipids in uremia: 'Carbonyl stress'

    R Inagi, T Miyata

    BLOOD PURIFICATION　17　(2-3)　95-98　1999年

    DOI： 10.1159/000014380 　

    ISSN： 0253-5068

  36. Development of a polyclonal antibody with broad epitope specificity for advanced glycation end products and localization of these epitpes in Bruch's membrane of the aging eye.

    Molecular Vision.　5　11　1999年

  37. Carbonyl stress : increased carbonyl modification of proteins by autoxidation products of carbohydrates and lipids in uremia.

    Int J Art Org　22　195-198　1999年

  38. Alterations in nonenzymatic biochemistry in uremia: Origin and significance of 'carbonyl stress' in long-term uremic complications

    Toshio Miyata, Charles Van Ypersele De Strihou, Kiyoshi Kurokawa, John W. Baynes

    Kidney International　55　(2)　389-399　1999年

    出版者・発行元： Blackwell Publishing Inc.

    DOI： 10.1046/j.1523-1755.1999.00302.x 　

    ISSN： 0085-2538

  39. Implication of carbonyl stress in long-term uraemic complications

    T Wada, T Miyata, K Kurokawa

    NEPHROLOGY DIALYSIS TRANSPLANTATION　14　(Suppl 1)　79-81　1999年

    ISSN： 0931-0509

  40. Diagnosis, pathogenesis, and treatment of dialysis-related amyloidosis

    T Miyata, R Inagi, K Kurokawa

    MINERAL AND ELECTROLYTE METABOLISM　25　(1-2)　114-117　1999年1月

    DOI： 10.1159/000057432 　

    ISSN： 0378-0392

  41. 2-Isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide (OPB-9195) treatment inhibits the development of intimal thickening. . .

    FEBS Letters Federation of European Biochemical Societies　445　202-206　1999年

    DOI： 10.1016/S0014-5793(99)00122-2 　

  42. Crry, a complement regulatory protein, modulates renal interstitial disease induced by proteinuria in rats.

    Kidney Int　56　(2096-2106)　1999年

    DOI： 10.1046/j.1523-1755.1999.00765.x 　

  43. Expression of megsin mRNA, a novel mesangium-predominant gene, in the renal tissues of various glomerular diseases.

    J Am Soc Nephrol　10　(2606-2613)　1999年

  44. Redox-oriented chemical events in signal transduction in cells.

    Redox Regulation of Cell Signaling and Its Clinical Application.　177-204　1999年

  45. β2-microglobulin and renal bone disease.

    Perit Dial Int　10　(Supple2)　413-416　1999年

  46. Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-src.

    J Cellular Biochemistry　72　(1-7)　1999年

    DOI： 10.1002/(SICI)1097-4644(19990101)72:1<1::AID-JCB1>3.0.CO;2-Y 　

  47. Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product: Carbonyl stress in uremia

    T Miyata, Y Ueda, Y Yamada, Y Izuhara, T Wada, M Jadoul, A Saito, K Kurokawa, CV De Strihou

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　9　(12)　2349-2356　1998年12月

    ISSN： 1046-6673

  48. Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: Is there oxidative stress in uremia?

    TR Miyata, MX Fu, K Kurokawa, C van Ypersele De Strihou, Thorpe, SR, JW Baynes

    KIDNEY INTERNATIONAL　54　(4)　1290-1295　1998年10月

    DOI： 10.1046/j.1523-1755.1998.00093.x 　

    ISSN： 0085-2538

  49. Plasma levels of pentosidine in diabetic patients: An advanced glycation end product

    S Sugiyama, T Miyata, Y Ueda, H Tanaka, K Maeda, S Kawashima, CV De Strihou, K Kurokawa

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　9　(9)　1681-1688　1998年9月

    ISSN： 1046-6673

  50. Localization of identified advanced glycation end-product structures, N-8-(carboxymethyl)lysine and pentosidine, in age-related inclusions in human brains

    T Kimura, J Takamatsu, T Miyata, T Miyakawa, S Horiuchi

    PATHOLOGY INTERNATIONAL　48　(8)　575-579　1998年8月

    ISSN： 1320-5463

  51. Increased aggregation of human platelets produced by advanced glycation end products in vitro

    M Hangaishi, J Taguchi, T Miyata, Y Ikari, M Togo, Y Hashimoto, T Watanabe, S Kimura, K Kurokawa, M Ohno

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　248　(2)　285-292　1998年7月

    DOI： 10.1006/bbrc.1998.8945 　

    ISSN： 0006-291X

  52. Accelerated formation of N-epsilon-(carboxymethyl) lysine, an advanced glycation end product, by glyoxal and 3-deoxyglucosone in cultured rat sensory neurons

    H Niwa, A Takeda, M Wakai, T Miyata, Y Yasuda, T Mitsuma, K Kurokawa, G Sobue

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　248　(1)　93-97　1998年7月

    DOI： 10.1006/bbrc.1998.8899 　

    ISSN： 0006-291X

  53. Alterations of synovial tissue and their potential role in the deposition of beta(2)-microglobulin-associated amyloid

    G Ehlerding, J Schaeffer, W Drommer, T Miyata, KM Koch, J Floege

    NEPHROLOGY DIALYSIS TRANSPLANTATION　13　(6)　1465-1475　1998年6月

    DOI： 10.1093/ndt/13.6.1465 　

    ISSN： 0931-0509

  54. Renal catabolism of advanced glycation end products: The fate of pentosidine

    T Miyata, Y Ueda, K Horie, M Nangaku, S Tanaka, CV de Strihou, K Kurokawa

    KIDNEY INTERNATIONAL　53　(2)　416-422　1998年2月

    DOI： 10.1046/j.1523-1755.1998.00756.x 　

    ISSN： 0085-2538

  55. Level of HgCl2-meditated phosphorylaiton of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmentation.

    J Cellular Biochemistry　71　(243-253)　1998年

    DOI： 10.1002/(SICI)1097-4644(19981101)71:2<243::AID-JCB9>3.0.CO;2-V 　

  56. Implication of altered redox regulation by antioxidant enzymes in the increased plasma pentosidine, an advanced glycation end product, in uremia.

    Biochem Biophys Res Commun　245　(3)　785-790　1998年

    DOI： 10.1006/bbrc.1998.8523 　

    ISSN： 0006-291X

  57. Implication of the glycoxidation and lipoxidation rections in the pathogenesis of dialysis-related amyloidosis.

    Int J Mol Med　2　561-565　1998年

  58. β2-Microgloburin in renal disease.

    J. Am Soc Nephrol　9　1723-1735　1998年

  59. A Mesangium-predominant Gene, Megsin, Is a New Serpin Upregulated in IgA Nephrology

    The Journal of Clinical Investigation The American Society for Clinical Investigation, Inc.　120　(4)　828-836　1998年

  60. Functional quantitative Analysis of the genome in cultured human mesangical cells

    Kidney International the Int'l Society of Nephrology　53　154-158　1998年

    DOI： 10.1046/j.1523-1755.1998.00751.x 　

  61. Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of. . .

    FEBS Letters Federation of Europan Biochemical Societies　437　(1/2)　24-28　1998年

    DOI： 10.1016/S0014-5793(98)01079-5 　

    ISSN： 0014-5793

  62. Immunohistochemical Evidence for an Increased for and Increased Oxidative Stress and Carbonyl Modification. . .

    Journal of the American Society of Nephrology the American Society of Nephrology　10　822-832　1998年

  63. Advanced glycation end products co-localization with astoricytes and microglial cells in Alzheimer's disease brain.

    Acta Neuropathol　98　555-558　1998年

    DOI： 10.1007/s004010050839 　

  64. Protein-bound acrolein : potential markers for oxidative stress.

    Proc Natl Acad Sci USA　95　(9)　4882-4887　1998年

    DOI： 10.1073/pnas.95.9.4882 　

    ISSN： 0027-8424

  65. Increased pentosidine, an davanced glycation end products, in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with markers of inflammation.

    Biochem Biophys Res Commun　244　(1)　45-49　1998年

    DOI： 10.1006/bbrc.1998.8203 　

    ISSN： 0006-291X

  66. Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain

    A Takeda, T Yasuda, T Miyata, K Mizuno, M Li, S Yoneyama, K Horie, K Maeda, G Sobue

    NEUROSCIENCE LETTERS　221　(1)　17-20　1996年12月

    DOI： 10.1016/S0304-3940(96)13275-4 　

    ISSN： 0304-3940

  67. Identification of advanced glycation end products of the Maillard reaction in Pick's disease

    T Kimura, K Ikeda, J Takamatsu, T Miyata, G Sobue, T Miyakawa, S Horiuchi

    NEUROSCIENCE LETTERS　219　(2)　95-98　1996年11月

    DOI： 10.1016/S0304-3940(96)13173-6 　

    ISSN： 0304-3940

  68. Alternate repetition of short fore- and backfiltrations reduces convective albumin loss

    T Shinzato, M Miwa, S Nakai, Takai, I, Y Matsumoto, H Morita, T Miyata, K Maeda

    KIDNEY INTERNATIONAL　50　(2)　432-435　1996年8月

    ISSN： 0085-2538

  69. Monocyte macrophage response to beta(2)-microglobulin modified with advanced glycation end products

    T Miyata, Y Iida, Y Ueda, T Shinzato, H Seo, VM Monnier, K Maeda, Y Wada

    KIDNEY INTERNATIONAL　49　(2)　538-550　1996年2月

    ISSN： 0085-2538

  70. Possible involvement of advanced glycation end-products in bone resorption

    T Miyata, R Kawai, S Taketomi, SM Sprague

    NEPHROLOGY DIALYSIS TRANSPLANTATION　11　(11Suppl5)　54-57　1996年

    ISSN： 0931-0509

  71. Advanced glycation end-products in diabetic nephropathy

    S Sugiyama, T Miyata, K Horie, Y Iida, M Tsuyuki, H Tanaka, K Maeda

    NEPHROLOGY DIALYSIS TRANSPLANTATION　11　(11Suppl5)　91-94　1996年

    ISSN： 0931-0509

  72. Advanced glycation of b2-microgloburin in the pathogenesis of bone lesions in dialysis assosiated amyloidosis.

    Nephrol Dial Transplant　(11Suppl3)　86-90　1996年

  73. New aspects in the pathogenesis of dialysis-related amyloidosis: Pathophysiology of advanced glycation end products in renal failure.

    MIYATA Toshio

    日本腎臓学会誌　38　(38)　191-197　1996年

    出版者・発行元： Japanese Society of Nephrology

    DOI： 10.14842/jpnjnephrol1959.38.191 　

    ISSN： 0385-2385

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    It has been demonstrated that β2-microglobulin is a major constituent of amyloid fibrils in dialysis-related amyloidosis, a serious complication leading to bone and joint destruction in long-term hemodialysis patients. However, the molecular pathogenesis of this complication remains unknown. Several lines of evidence suggest that β2-microglobulin plays an active role in the development of dialysis-related amyloidosis. It is unlikely that intact β2-microglobulin per se contributes to the pathogenesis, because no difference in the plasma levels of intact β2-microglobulin has yet been found between hemodialysis patients with and without this complication. Some investigators, therefore, have focused on the modification of this molecule. Recent studies have revealed a new modification of β2-microglobulin in amyloid fibrils: advanced glycation end products (AGES) formed by a nonenzymatic reaction between aldoses and proteins. Further studies have suggested that the interaction of AGE-modified β2-microglobulin with monocyte/macrophage and osteoblast/osteoblast gives a plausible, albeit partial, explanation for the mechanism of bone and joint destruction in dialysis-related amyloidosis. This article focuses on the modification of β2-microglobulin with AGEs, especially on their structure and pathological role in dialysis-related amyloidosis. Furthermore, the implication of renal failure in the pathophysiology of AGES is also discussed.

  74. Advanced glycation end products and b2-microglobulin : The story unfolds.

    Nephrol Dial Transplan　(11)　934-936　1996年

  75. Adranced glycation end prodcuts and B2-microglobulin : The story unfolds.

    Nephrol Dial Transplant　11　934-936　1996年

  76. Identification of pentosidine as a native structure for advanced glycation end products in B2-microglobulin forming amyloid fibrils in patients with dialysis-related amyloidosis

    Proc Natl Acad Sci USA　93　(6)　2353-2358　1996年

    DOI： 10.1073/pnas.93.6.2353 　

    ISSN： 0027-8424

  77. b2-Microglobulin modified with advanced glycation end products induces monocyte chemotaxis in vivo.

    Nephrol Dial Transplant　(11)　1181-1191　1996年

  78. New aspects in the pothogenesis of dialysis-relat amyloidosis : Role of B2-microglobulin modified with advanced glycation end products inbone and joint destRuction.

    Nephrol Dial Transplant　11　140　1996年

  79. 腎疾患の診断と治療:現状と展望

    日本内科学会雑誌(社)日本内科学会　85　(10)　108-126　1996年

  80. Accumulation of alubumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure : Renal implications in the pathophysiology of pentosidine.

    J Am Soc Nephrol　(7)　1198-1206　1996年

  81. Identification of pentosidine as a native structure for advanced glycation end products in b2-microglobulin containing amyloid fibrils in patients with dialysis-related amyloidosis

    Proc Natl Acad Sci USA　93　(6)　2353-2358　1996年

    DOI： 10.1073/pnas.93.6.2353 　

    ISSN： 0027-8424

  82. Pathophysiology of advanced glycation end-products in renal failure

    T Miyata, Y Iida, K Horie, Z Cai, S Sugiyama, K Maeda

    NEPHROLOGY DIALYSIS TRANSPLANTATION　11　(11Suppl5)　27-30　1996年

    ISSN： 0931-0509

  83. Alternate repetition of short fore-and backfiltrations reduces convective albumin loss.

    Kidney Int　(50)　432-435　1996年

  84. Monocyte/macrophage response to b2-microglobulin modified with advanced glycation end products.

    Kidney Int　(49)　538-550　1996年

  85. New aspects in the pathogenesis of dialysis-related amyloidosis : Role of b2-microglobulin modified with advanced glycation end products in bone and joint destruction.

    Nephrol Dial Transplant　(11Suppl2)　140-143　1996年

  86. b2-microglobuline modified with the advanced glycation end products of the maillard Reaction indialysis-related amyloidosis

    Dialysis-related amyloidosis　(66)　285-290　1995年

  87. Glycation of human b2-microglobulin in patients with hemodialysis-associated smyloidosis : Somatic mutations of the PIG-A gene found in Japanease patients with paroxysmal nocturnal hemoglobinuria.

    Blood　(85)　885-892　1995年

  88. Involvement of b2-microglobulin modified with AGEs in dialysis-related amyloidosis.

    Dialysis Amyloid　215-224　1995年

  89. b2-microglobulin modified with the advanced glycation end products of the maillard reaction in dialysis-related amyloidosis.

    Japan-France Nephrology 1994　5-8　1995年

  90. Effectiveness of new push/pull hemodiafiltration for arthralgia in long-term hemodialysis patients

    T SHINZATO, M MIWA, H KOBAYAKAWA, H MORITA, S NAKAI, T MIYATA, K MAEDA

    DIALYSIS-RELATED AMYLOIDOSIS　112　111-118　1995年

    ISSN： 0302-5144

  91. Involvement of b2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis : Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-a and interleukin 1.

    J Clin Invest　(93)　521-528　1994年

  92. Expression cloning of genes for GPI-anchor biosynthesis.

    Brazil J Med Biol Res　(27)　127-132　1994年

  93. Inhibitory effect of FUT-175 on complement activation and its application for glomerulonephritis with hypocomplementemia

    Yoshiro Fujita, Itaru Inoue, Toshio Miyata, Takahiro Shinzato, Satoshi Sugiyama, Kenji Maeda, Reiko Inagi, Akio Miyama

    the japanese journal of nephrology　35　(4)　393-397　1994年

    DOI： 10.14842/jpnjnephrol1959.35.393 　

    ISSN： 0385-2385

  94. Characterization of genomic PIG-A gene : A gene for GPI-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria.

    Blood　(93)　521-528　1994年

  95. Evaluation of the proteolytic activity of factor D accumulated as an active serine protease in patients with chronic renal failure.

    Nephron　(66)　285-290　1994年

  96. b2-Microglobulin modified with advanced glycation end products induces interleukin-6 from human macrophages : Role in the pathogenesis of hemodialysis-associated amyloidosis.

    Biochem Biophys Res Commun　(201)　1235-1241　1994年

    DOI： 10.1006/bbrc.1994.1837 　

  97. Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria.

    N Engl J Med　330　(4)　249-255　1994年

    DOI： 10.1056/NEJM199401273300404 　

    ISSN： 0028-4793

  98. Paroxysmal nocturnal haemoglobinuria(PNH)is caused by somatic mutations in the PIG-A gene.

    EMBO J　(13)　110-117　1994年

  99. DEFICIENCY OF THE GPI ANCHOR CAUSED BY A SOMATIC MUTATION OF THE PIG-A GENE IN PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA

    J TAKEDA, T MIYATA, K KAWAGOE, Y IIDA, Y ENDO, T FUJITA, M TAKAHASHI, T KITANI, T KINOSHITA

    CELL　73　(4)　703-711　1993年5月

    DOI： 10.1016/0092-8674(93)90250-T 　

    ISSN： 0092-8674

  100. Effectiveness of nafamostat mesilate on glomerulonephritis in immune-complex diseases.

    Lancet　(341)　1353　1993年

  101. b2-microglobulin modified with advanced glycation end products is a major component of. hemodialysis-associated amyloidosis

    J Clin Invest　(92)　1243-1252　1993年

  102. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis.

    Science　259　(5099)　1318-1320　1993年

    DOI： 10.1126/science.7680492 　

    ISSN： 0036-8075

  103. Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria.

    J Exp Med　177　(2)　517-521　1993年

    DOI： 10.1084/jem.177.2.517 　

    ISSN： 0022-1007

  104. Decreased clearance of immune complexes in patients on hemodialysis.

    Clin Immunol Immunopathol　(68)　333-339　1993年

  105. Effects of excess factor D on early- and late-phase activation of the complement cascade

    Hiroyuki Kobayakawa, Toshio Miyata, Reiko In Agp, Takahiro Shinzato, Kenji Maeda

    The Japanese Journal of Nephrology　34　(1)　103-106　1992年

    DOI： 10.14842/jpnjnephrol1959.34.103 　

    ISSN： 0385-2385

  106. Fluid-phase activation of the alternative pathway of complement by excess factor D in regularly dialyzed patients.

    Nephron　(60)　144-149　1992年

  107. DETERIORATION OF IMMUNE-COMPLEX SOLUBILIZATION ACTIVITY OF SERUM BY INCREASED CONCENTRATION OF FACTOR-D

    T MIYATA, R INAGI, O ODA, INOUE, I, H OKADA, A MIYAMA, NAKASHIMA, I, K MAEDA

    NEPHRON　59　(3)　409-415　1991年11月

    ISSN： 0028-2766

  108. Detection of circulating immune complexes in patients on hemodialysis by a new immunoassay.

    Nephron　(58)　244-245　1991年

  109. FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a.

    Immunology Letters　(27)　49-52　1991年

  110. MOLECULAR AND FUNCTIONAL IDENTIFICATION AND PURIFICATION OF COMPLEMENT COMPONENT FACTOR-D FROM URINE OF PATIENTS WITH CHRONIC-RENAL-FAILURE

    T MIYATA, O ODA, R INAGI, S SUGIYAMA, A MIYAMA, K MAEDA, NAKASHIMA, I, N YAMANAKA

    MOLECULAR IMMUNOLOGY　27　(7)　637-644　1990年7月

    DOI： 10.1016/0161-5890(90)90006-L 　

    ISSN： 0161-5890

  111. Determination of the molecular nature and cellular localization of Thy-1 in human renal tissue.

    Immunology　(69)　391-395　1990年

  112. Rat mesangial cells actively produce phospatidylinositol-anchored Thy-1.

    Immunology　(67)　531-533　1989年

  113. Further evidence for H-2-unrestricted induction of minor histocompatibility antigens-specific T cell immunity in vivo.

    Immunology Letters　(19)　41-48　1988年

  114. Relevance of oxidative and carbonyl stress to long-term uremic complications.

    Kidney Int　58　(Suppl 76)　120-125

  115. Implication of carbonyl stress in long-term uremic complications.

    Blood Purification

  116. Increased oxidative stress in the mouse kidneys withunilateral ureteral obstruction.

    Kidney International

    DOI： 10.1046/j.1523-1755.1999.00612.x 　

  117. Neurotoxicity of methylglyxal and 3-Deoxyglycose on cultured cortical neurons : Synergism between glycation and oxidative stress, possibly involved in neurodegnerative diseases.

    Neurosci letter

  118. Advanced glycation end products potentiate human platelet aggregation in vitro : Possible role of oxdative stress.

    Biochem Biophys Res Commun

  119. Rapid formation of advanced glycation end products following vascular injury in euglycemic rat carotid artery : Role of oxidative stress.

    Circulation Research

  120. Stress carbonyl(]E85EE[) et complications a long terme de I' ur(]E85EE[)mie, in ACTUALIT(]E85D8[)S N(]E85D8[)PHROLOGIQUES JEAN HAMBURGER. H(]E87C7[)PITAL NECKER 1998(eds. Grundfeld JP, Bach JF, Kreis H)

    M(]E85EE[)decine-Sciences Flammarion.　247-253

  121. The receptor for advanced glycation end-products(RAGE)is a central mediator of the interaction of AGE-b2microglobulin with human mononuclearphagocytes via an oxidant-sensitive pathway : implications for the pathogenesis of dialysis-related amyloidosis.

    J Clin Invest　(98)　1088-1094

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    1196

  122. "Carbonyl Stress"and long-term uremic complications.

    Advanced in Nephrology

︎全件表示 ︎最初の5件までを表示

書籍等出版物 3

  1. Alterations in nonenzymatic biochemistry of carbohydrates and lipids in uremia.

    Massry and Glassock's Text Book of Nephrology　2001年

  2. Expression cloning strategies for GPI-anchor biosynthesis enzymes and regulators. Lipid modifications of proteins(Methods in Enzymology).

    Casey PJ and Buss JE, editers.　1995年

  3. Pathogeneis of dialysis-related amyloidosis.

    Current Opinion in Nephrology and Hypertension　1995年

共同研究・競争的資金等の研究課題 4

  1. 糖酸化反応経路の解明、及び糖酸化ストレスのシグナリングとレドックス制御機構の解明 競争的資金

  2. Elucidation of glycoxidation pathway mechanism of signal tranducing and redox regulation 競争的資金

  3. 腎臓の形態・機能に関与する腎臓特異的遺伝子の解析 競争的資金

  4. Heutification of Kidney Specific Genes Related to the Morphdogy and Function of Kidney 競争的資金