Advanced glycation and lipoxidation end products: reactive carbonyl compounds-related uraemic toxicity

T Miyata, A Saito, K Kurokawa, CV de Strihou

NEPHROLOGY DIALYSIS TRANSPLANTATION　16　(16Suppl 4)　8-11　2001

ISSN： 0931-0509

Reactive carbonyl compounds as uremic toxins.

Contrib Nephrol　(133)　71-80　2001

b2-Microglobulin modified with advanced glycation end products delays monocyte apoptosis and induces differenciation into macrophage-like cells.

Kidney Int　(59)　990-1002　2001

DOI： 10.1046/j.1523-1755.2001.059003990.x 　

Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis

S Combet, T Miyata, P Moulin, D Pouthier, E Goffin, O Devuyst

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　11　(4)　717-728　2000/04

ISSN： 1046-6673

Nitric oxide inhibits the formation of advanced glycation and products.

Kidney Int　(58)　1780-1787　2000

DOI： 10.1046/j.1523-1755.2000.00340.x 　

Induction of apoptosis by glyoxal in human embryonic lung epithelial cell line L132.

Am J Respi Cell Mol Biol　(487-491)　23　2000

Advanced glycation and lipoxidation of the peritoneal membrane : Respective roles of serum and peritoneal fluid reactive carbonyl compounds.

Kidney Int　58　(425-435)　2000

DOI： 10.1046/j.1523-1755.2000.00182.x 　

Advanced glycation and lipoxidation end products : Role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism.

J Am Soc Nephrol　11　(1744-1752)　2000

4-Hydroxynonenal induces a cellular redox-related activation of the caspase. cascade for apoptotic cell death

J Cell Sci　113　(635-641)　2000

'Carbonyl stress' and dialysis-related amyloidosis

T Miyata, Y Ueda, A Saito, K Kurokawa

NEPHROLOGY DIALYSIS TRANSPLANTATION　15　(Suppl. 1)　25-28　2000

ISSN： 0931-0509

Methylglyoxal induces apoptosis in jurkat leukemia T-cells by activating c-Jun N-terminal kinase.

J Cell Biochem　77　(2)　333-344　2000

DOI： 10.1002/(SICI)1097-4644(20000501)77:2<333::AID-JCB15>3.0.CO;2-Q 　

ISSN： 0730-2312

Mechanism of inhibitory effect of OPB-9195[(±)2-isopropylidenehydrazono-4-oxothiazolidin-5ylacetanilide]on AGE and ALE formation. Advanced lipoxidation end product formation.

J Am Soc Nephrol　11　(1719-1725)　2000

Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction

N Kawada, T Moriyama, A Ando, M Fukunaga, T Miyata, K Kurokawa, E Imai, M Hori

KIDNEY INTERNATIONAL　56　(3)　1004-1013　1999/09

DOI： 10.1046/j.1523-1755.1999.00612.x 　

ISSN： 0085-2538

4-hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition

W Liu, AA Akhand, M Kato, Yokoyama, I, T Miyata, K Kurokawa, K Uchida, Nakashima, I

JOURNAL OF CELL SCIENCE　112　(14)　2409-2417　1999/07

ISSN： 0021-9533

Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney

T Miyata, S Sugiyama, M Nangaku, D Suzuki, KI Uragami, R Inagi, H Sakai, K Kurokawa

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　10　(7)　1590-1595　1999/07

ISSN： 1046-6673

Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: Synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases

S Kikuchi, K Shinpo, F Moriwaka, Z Makita, T Miyata, K Tashiro

JOURNAL OF NEUROSCIENCE RESEARCH　57　(2)　280-289　1999/07

DOI： 10.1002/(SICI)1097-4547(19990715)57:2<280::AID-JNR14>3.0.CO;2-U 　

ISSN： 0360-4012

Decrease in serum pentosidine levels of ESRD patients during polysulfone haemodialysis

G Stein, S Franke, H Sperschneider, J Vienken, Y Ueda, T Miyata, K Kurokawa

NEPHROLOGY DIALYSIS TRANSPLANTATION　14　(6)　1606-1608　1999/06

DOI： 10.1093/ndt/14.6.1606 　

ISSN： 0931-0509

Influence of hemodialysis membrane type on pentosidine plasma level, a marker of "carbonyl stress"

M Jadoul, Y Ueda, Y Yasuda, A Saito, A Robert, N Ishida, K Kurokawa, CV de Strihou, T Miyata

KIDNEY INTERNATIONAL　55　(6)　2487-2492　1999/06

DOI： 10.1046/j.1523-1755.1999.00468.x 　

ISSN： 0085-2538

Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions

D Suzuki, T Miyata, N Saotome, K Horie, R Inagi, Y Yasuda, K Uchida, Y Izuhara, M Yagame, H Sakai, K Kurokawa

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　10　(4)　822-832　1999/04

ISSN： 1046-6673

A sensitive and specific ELISA for plasma pentosidine

Y Izuhara, T Miyata, Y Ueda, D Suzuki, K Asahi, R Inagi, H Sakai, K Kurokawa

NEPHROLOGY DIALYSIS TRANSPLANTATION　14　(3)　576-580　1999/03

ISSN： 0931-0509

Increase in the advanced glycation end product pentosidine in Bruch's membrane with age

JT Handa, N Verzijl, H Matsunaga, A Aotaki-Keen, GA Lutty, JMT Koppele, T Miyata, LM Hjelmeland

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　40　(3)　775-779　1999/03

ISSN： 0146-0404

Possible involvement of"carbonyl stress"in the pathogenesis of dialysis-related amyloidosis.

Am J Med Sci　317　410-415　1999

Nitric oxide controles src kinase activity through a sulfhydryl group modification mediated Tyr-527-independent and Try-416-linked mechanism.

J Biol Chem　274　(36)　25821-25826　1999

DOI： 10.1074/jbc.274.36.25821 　

ISSN： 0021-9258

Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy.

Kidney Int　56　(71)　S54-56　1999

Carbonyl stress : Increased carbonyl modification of tissue and cellular proteins in uremia.

Perit Dial Int　19　(Supple 2)　58-61　1999

Oxdative stress-induced "Carbonylstress" in uremia.

Redox Regulation of Cell Signaling and Its Clinical Application.　215-224　1999

Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src

Anwarul A. Akhand, Masashi Kato, Haruhiko Suzuki, Wei Liu, Jun Du, Michinari Hamaguchi, Toshio Miyata, Kiyoshi Kurokawa, Izumi Nakashima

Journal of Cellular Biochemistry　72　(1)　1-7　1999/01/01

DOI： 10.1002/(SICI)1097-4644(19990101)72:1<1::AID-JCB1>3.0.CO;2-Y 　

ISSN： 0730-2312

Carbonyl stress and diabetic nephropathy.

Daisuke SUZUKI, Toshio MIYATA

Internal Medicine　38　(4)　309-314　1999

DOI： 10.2169/internalmedicine.38.309 　

ISSN： 0918-2918 1349-7235

Glucose degradation product methylglyoxal enhances the production of vascular endothelial growth factor in peritoneal cells : Role in the functional and morphological alterations of peritoneal membrane dysfunction in peritoneal dialysis.

FEBS Letter　463　(260-264)　1999

DOI： 10.1016/S0014-5793(99)01642-7 　

Oxidative protein damage with carbohydrates and lipids in uremia: 'Carbonyl stress'

R Inagi, T Miyata

BLOOD PURIFICATION　17　(2-3)　95-98　1999

DOI： 10.1159/000014380 　

ISSN： 0253-5068

Development of a polyclonal antibody with broad epitope specificity for advanced glycation end products and localization of these epitpes in Bruch's membrane of the aging eye.

Molecular Vision.　5　11　1999

Carbonyl stress : increased carbonyl modification of proteins by autoxidation products of carbohydrates and lipids in uremia.

Int J Art Org　22　195-198　1999

Alterations in nonenzymatic biochemistry in uremia: Origin and significance of 'carbonyl stress' in long-term uremic complications

Toshio Miyata, Charles Van Ypersele De Strihou, Kiyoshi Kurokawa, John W. Baynes

Kidney International　55　(2)　389-399　1999

DOI： 10.1046/j.1523-1755.1999.00302.x 　

ISSN： 0085-2538

Implication of carbonyl stress in long-term uraemic complications

T Wada, T Miyata, K Kurokawa

NEPHROLOGY DIALYSIS TRANSPLANTATION　14　(Suppl 1)　79-81　1999

ISSN： 0931-0509

Diagnosis, pathogenesis, and treatment of dialysis-related amyloidosis

T Miyata, R Inagi, K Kurokawa

MINERAL AND ELECTROLYTE METABOLISM　25　(1-2)　114-117　1999/01

DOI： 10.1159/000057432 　

ISSN： 0378-0392

2-Isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide (OPB-9195) treatment inhibits the development of intimal thickening. . .

FEBS Letters Federation of European Biochemical Societies　445　202-206　1999

DOI： 10.1016/S0014-5793(99)00122-2 　

Crry, a complement regulatory protein, modulates renal interstitial disease induced by proteinuria in rats.

Kidney Int　56　(2096-2106)　1999

DOI： 10.1046/j.1523-1755.1999.00765.x 　

Expression of megsin mRNA, a novel mesangium-predominant gene, in the renal tissues of various glomerular diseases.

J Am Soc Nephrol　10　(2606-2613)　1999

Redox-oriented chemical events in signal transduction in cells.

Redox Regulation of Cell Signaling and Its Clinical Application.　177-204　1999

β2-microglobulin and renal bone disease.

Perit Dial Int　10　(Supple2)　413-416　1999

Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60^c-src.

J Cellular Biochemistry　72　(1-7)　1999

DOI： 10.1002/(SICI)1097-4644(19990101)72:1<1::AID-JCB1>3.0.CO;2-Y 　

Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product: Carbonyl stress in uremia

T Miyata, Y Ueda, Y Yamada, Y Izuhara, T Wada, M Jadoul, A Saito, K Kurokawa, CV De Strihou

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　9　(12)　2349-2356　1998/12

ISSN： 1046-6673

Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: Is there oxidative stress in uremia?

TR Miyata, MX Fu, K Kurokawa, C van Ypersele De Strihou, Thorpe, SR, JW Baynes

KIDNEY INTERNATIONAL　54　(4)　1290-1295　1998/10

DOI： 10.1046/j.1523-1755.1998.00093.x 　

ISSN： 0085-2538

Plasma levels of pentosidine in diabetic patients: An advanced glycation end product

S Sugiyama, T Miyata, Y Ueda, H Tanaka, K Maeda, S Kawashima, CV De Strihou, K Kurokawa

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　9　(9)　1681-1688　1998/09

ISSN： 1046-6673

Localization of identified advanced glycation end-product structures, N-8-(carboxymethyl)lysine and pentosidine, in age-related inclusions in human brains

T Kimura, J Takamatsu, T Miyata, T Miyakawa, S Horiuchi

PATHOLOGY INTERNATIONAL　48　(8)　575-579　1998/08

ISSN： 1320-5463

Increased aggregation of human platelets produced by advanced glycation end products in vitro

M Hangaishi, J Taguchi, T Miyata, Y Ikari, M Togo, Y Hashimoto, T Watanabe, S Kimura, K Kurokawa, M Ohno

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　248　(2)　285-292　1998/07

DOI： 10.1006/bbrc.1998.8945 　

ISSN： 0006-291X

Accelerated formation of N-epsilon-(carboxymethyl) lysine, an advanced glycation end product, by glyoxal and 3-deoxyglucosone in cultured rat sensory neurons

H Niwa, A Takeda, M Wakai, T Miyata, Y Yasuda, T Mitsuma, K Kurokawa, G Sobue

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　248　(1)　93-97　1998/07

DOI： 10.1006/bbrc.1998.8899 　

ISSN： 0006-291X

Alterations of synovial tissue and their potential role in the deposition of beta(2)-microglobulin-associated amyloid

G Ehlerding, J Schaeffer, W Drommer, T Miyata, KM Koch, J Floege

NEPHROLOGY DIALYSIS TRANSPLANTATION　13　(6)　1465-1475　1998/06

DOI： 10.1093/ndt/13.6.1465 　

ISSN： 0931-0509

Renal catabolism of advanced glycation end products: The fate of pentosidine

T Miyata, Y Ueda, K Horie, M Nangaku, S Tanaka, CV de Strihou, K Kurokawa

KIDNEY INTERNATIONAL　53　(2)　416-422　1998/02

DOI： 10.1046/j.1523-1755.1998.00756.x 　

ISSN： 0085-2538

Level of HgCl₂-meditated phosphorylaiton of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmentation.

J Cellular Biochemistry　71　(243-253)　1998

DOI： 10.1002/(SICI)1097-4644(19981101)71:2<243::AID-JCB9>3.0.CO;2-V 　

Implication of altered redox regulation by antioxidant enzymes in the increased plasma pentosidine, an advanced glycation end product, in uremia.

Biochem Biophys Res Commun　245　(3)　785-790　1998

DOI： 10.1006/bbrc.1998.8523 　

ISSN： 0006-291X

Implication of the glycoxidation and lipoxidation rections in the pathogenesis of dialysis-related amyloidosis.

Int J Mol Med　2　561-565　1998

β2-Microgloburin in renal disease.

J. Am Soc Nephrol　9　1723-1735　1998

A Mesangium-predominant Gene, Megsin, Is a New Serpin Upregulated in IgA Nephrology

The Journal of Clinical Investigation The American Society for Clinical Investigation, Inc.　120　(4)　828-836　1998

Functional quantitative Analysis of the genome in cultured human mesangical cells

Kidney International the Int'l Society of Nephrology　53　154-158　1998

DOI： 10.1046/j.1523-1755.1998.00751.x 　

Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of. . .

FEBS Letters Federation of Europan Biochemical Societies　437　(1/2)　24-28　1998

DOI： 10.1016/S0014-5793(98)01079-5 　

ISSN： 0014-5793

Immunohistochemical Evidence for an Increased for and Increased Oxidative Stress and Carbonyl Modification. . .

Journal of the American Society of Nephrology the American Society of Nephrology　10　822-832　1998

Advanced glycation end products co-localization with astoricytes and microglial cells in Alzheimer's disease brain.

Acta Neuropathol　98　555-558　1998

DOI： 10.1007/s004010050839 　

Protein-bound acrolein : potential markers for oxidative stress.

Proc Natl Acad Sci USA　95　(9)　4882-4887　1998

DOI： 10.1073/pnas.95.9.4882 　

ISSN： 0027-8424

Increased pentosidine, an davanced glycation end products, in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with markers of inflammation.

Biochem Biophys Res Commun　244　(1)　45-49　1998

DOI： 10.1006/bbrc.1998.8203 　

ISSN： 0006-291X

Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain

A Takeda, T Yasuda, T Miyata, K Mizuno, M Li, S Yoneyama, K Horie, K Maeda, G Sobue

NEUROSCIENCE LETTERS　221　(1)　17-20　1996/12

DOI： 10.1016/S0304-3940(96)13275-4 　

ISSN： 0304-3940

Identification of advanced glycation end products of the Maillard reaction in Pick's disease

T Kimura, K Ikeda, J Takamatsu, T Miyata, G Sobue, T Miyakawa, S Horiuchi

NEUROSCIENCE LETTERS　219　(2)　95-98　1996/11

DOI： 10.1016/S0304-3940(96)13173-6 　

ISSN： 0304-3940

Alternate repetition of short fore- and backfiltrations reduces convective albumin loss

T Shinzato, M Miwa, S Nakai, Takai, I, Y Matsumoto, H Morita, T Miyata, K Maeda

KIDNEY INTERNATIONAL　50　(2)　432-435　1996/08

ISSN： 0085-2538

Monocyte macrophage response to beta(2)-microglobulin modified with advanced glycation end products

T Miyata, Y Iida, Y Ueda, T Shinzato, H Seo, VM Monnier, K Maeda, Y Wada

KIDNEY INTERNATIONAL　49　(2)　538-550　1996/02

ISSN： 0085-2538

Possible involvement of advanced glycation end-products in bone resorption

T Miyata, R Kawai, S Taketomi, SM Sprague

NEPHROLOGY DIALYSIS TRANSPLANTATION　11　(11Suppl5)　54-57　1996

ISSN： 0931-0509

Advanced glycation end-products in diabetic nephropathy

S Sugiyama, T Miyata, K Horie, Y Iida, M Tsuyuki, H Tanaka, K Maeda

NEPHROLOGY DIALYSIS TRANSPLANTATION　11　(11Suppl5)　91-94　1996

ISSN： 0931-0509

Advanced glycation of b2-microgloburin in the pathogenesis of bone lesions in dialysis assosiated amyloidosis.

Nephrol Dial Transplant　(11Suppl3)　86-90　1996

New aspects in the pathogenesis of dialysis-related amyloidosis : Pathophysiology advanced glycation end products in renal failure.

MIYATA Toshio

Jpn J Nephrol　38　(38)　191-197　1996

DOI： 10.14842/jpnjnephrol1959.38.191 　

ISSN： 0385-2385

Advanced glycation end products and b2-microglobulin : The story unfolds.

Nephrol Dial Transplan　(11)　934-936　1996

Adranced glycation end prodcuts and B₂-microglobulin : The story unfolds.

Nephrol Dial Transplant　11　934-936　1996

Identification of pentosidine as a native structure for advanced glycation end products in B₂-microglobulin forming amyloid fibrils in patients with dialysis-related amyloidosis

Proc Natl Acad Sci USA　93　(6)　2353-2358　1996

DOI： 10.1073/pnas.93.6.2353 　

ISSN： 0027-8424

b2-Microglobulin modified with advanced glycation end products induces monocyte chemotaxis in vivo.

Nephrol Dial Transplant　(11)　1181-1191　1996

New aspects in the pothogenesis of dialysis-relat amyloidosis : Role of B₂-microglobulin modified with advanced glycation end products inbone and joint destRuction.

Nephrol Dial Transplant　11　140　1996

腎疾患の診断と治療:現状と展望

日本内科学会雑誌(社)日本内科学会　85　(10)　108-126　1996

Accumulation of alubumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure : Renal implications in the pathophysiology of pentosidine.

J Am Soc Nephrol　(7)　1198-1206　1996

Identification of pentosidine as a native structure for advanced glycation end products in b2-microglobulin containing amyloid fibrils in patients with dialysis-related amyloidosis

Proc Natl Acad Sci USA　93　(6)　2353-2358　1996

DOI： 10.1073/pnas.93.6.2353 　

ISSN： 0027-8424

Pathophysiology of advanced glycation end-products in renal failure

T Miyata, Y Iida, K Horie, Z Cai, S Sugiyama, K Maeda

NEPHROLOGY DIALYSIS TRANSPLANTATION　11　(11Suppl5)　27-30　1996

ISSN： 0931-0509

Alternate repetition of short fore-and backfiltrations reduces convective albumin loss.

Kidney Int　(50)　432-435　1996

Monocyte/macrophage response to b2-microglobulin modified with advanced glycation end products.

Kidney Int　(49)　538-550　1996

New aspects in the pathogenesis of dialysis-related amyloidosis : Role of b2-microglobulin modified with advanced glycation end products in bone and joint destruction.

Nephrol Dial Transplant　(11Suppl2)　140-143　1996

b2-microglobuline modified with the advanced glycation end products of the maillard Reaction indialysis-related amyloidosis

Dialysis-related amyloidosis　(66)　285-290　1995

Glycation of human b2-microglobulin in patients with hemodialysis-associated smyloidosis : Somatic mutations of the PIG-A gene found in Japanease patients with paroxysmal nocturnal hemoglobinuria.

Blood　(85)　885-892　1995

Involvement of b2-microglobulin modified with AGEs in dialysis-related amyloidosis.

Dialysis Amyloid　215-224　1995

b2-microglobulin modified with the advanced glycation end products of the maillard reaction in dialysis-related amyloidosis.

Japan-France Nephrology 1994　5-8　1995

Effectiveness of new push/pull hemodiafiltration for arthralgia in long-term hemodialysis patients

T SHINZATO, M MIWA, H KOBAYAKAWA, H MORITA, S NAKAI, T MIYATA, K MAEDA

DIALYSIS-RELATED AMYLOIDOSIS　112　111-118　1995

ISSN： 0302-5144

Involvement of b2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis : Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-a and interleukin 1.

J Clin Invest　(93)　521-528　1994

Expression cloning of genes for GPI-anchor biosynthesis.

Brazil J Med Biol Res　(27)　127-132　1994

Inhibitory effect of FUT-175 on complement activation and its application for glomerulonephritis with hypocomplementemia

Yoshiro Fujita, Itaru Inoue, Toshio Miyata, Takahiro Shinzato, Satoshi Sugiyama, Kenji Maeda, Reiko Inagi, Akio Miyama

the japanese journal of nephrology　35　(4)　393-397　1994

DOI： 10.14842/jpnjnephrol1959.35.393 　

ISSN： 0385-2385

Characterization of genomic PIG-A gene : A gene for GPI-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria.

Blood　(93)　521-528　1994

Evaluation of the proteolytic activity of factor D accumulated as an active serine protease in patients with chronic renal failure.

Nephron　(66)　285-290　1994

b2-Microglobulin modified with advanced glycation end products induces interleukin-6 from human macrophages : Role in the pathogenesis of hemodialysis-associated amyloidosis.

Biochem Biophys Res Commun　(201)　1235-1241　1994

DOI： 10.1006/bbrc.1994.1837 　

Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria.

N Engl J Med　330　(4)　249-255　1994

DOI： 10.1056/NEJM199401273300404 　

ISSN： 0028-4793

Paroxysmal nocturnal haemoglobinuria(PNH)is caused by somatic mutations in the PIG-A gene.

EMBO J　(13)　110-117　1994

DEFICIENCY OF THE GPI ANCHOR CAUSED BY A SOMATIC MUTATION OF THE PIG-A GENE IN PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA

J TAKEDA, T MIYATA, K KAWAGOE, Y IIDA, Y ENDO, T FUJITA, M TAKAHASHI, T KITANI, T KINOSHITA

CELL　73　(4)　703-711　1993/05

DOI： 10.1016/0092-8674(93)90250-T 　

ISSN： 0092-8674

Effectiveness of nafamostat mesilate on glomerulonephritis in immune-complex diseases.

Lancet　(341)　1353　1993

b2-microglobulin modified with advanced glycation end products is a major component of. hemodialysis-associated amyloidosis

J Clin Invest　(92)　1243-1252　1993

The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis.

Science　259　(5099)　1318-1320　1993

DOI： 10.1126/science.7680492 　

ISSN： 0036-8075

Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria.

J Exp Med　177　(2)　517-521　1993

DOI： 10.1084/jem.177.2.517 　

ISSN： 0022-1007

Decreased clearance of immune complexes in patients on hemodialysis.

Clin Immunol Immunopathol　(68)　333-339　1993

Effects of excess factor D on early- and late-phase activation of the complement cascade

Hiroyuki Kobayakawa, Toshio Miyata, Reiko In Agp, Takahiro Shinzato, Kenji Maeda

The Japanese Journal of Nephrology　34　(1)　103-106　1992

DOI： 10.14842/jpnjnephrol1959.34.103 　

ISSN： 0385-2385

Fluid-phase activation of the alternative pathway of complement by excess factor D in regularly dialyzed patients.

Nephron　(60)　144-149　1992

DETERIORATION OF IMMUNE-COMPLEX SOLUBILIZATION ACTIVITY OF SERUM BY INCREASED CONCENTRATION OF FACTOR-D

T MIYATA, R INAGI, O ODA, INOUE, I, H OKADA, A MIYAMA, NAKASHIMA, I, K MAEDA

NEPHRON　59　(3)　409-415　1991/11

ISSN： 0028-2766

Detection of circulating immune complexes in patients on hemodialysis by a new immunoassay.

Nephron　(58)　244-245　1991

FUT-175 as a potent inhibitor of C5/C3 convertase activity for production of C5a and C3a.

Immunology Letters　(27)　49-52　1991

MOLECULAR AND FUNCTIONAL IDENTIFICATION AND PURIFICATION OF COMPLEMENT COMPONENT FACTOR-D FROM URINE OF PATIENTS WITH CHRONIC-RENAL-FAILURE

T MIYATA, O ODA, R INAGI, S SUGIYAMA, A MIYAMA, K MAEDA, NAKASHIMA, I, N YAMANAKA

MOLECULAR IMMUNOLOGY　27　(7)　637-644　1990/07

DOI： 10.1016/0161-5890(90)90006-L 　

ISSN： 0161-5890

Determination of the molecular nature and cellular localization of Thy-1 in human renal tissue.

Immunology　(69)　391-395　1990

Rat mesangial cells actively produce phospatidylinositol-anchored Thy-1.

Immunology　(67)　531-533　1989

Further evidence for H-2-unrestricted induction of minor histocompatibility antigens-specific T cell immunity in vivo.

Immunology Letters　(19)　41-48　1988

Relevance of oxidative and carbonyl stress to long-term uremic complications.

Kidney Int　58　(Suppl 76)　120-125

Implication of carbonyl stress in long-term uremic complications.

Blood Purification

Increased oxidative stress in the mouse kidneys withunilateral ureteral obstruction.

Kidney International

DOI： 10.1046/j.1523-1755.1999.00612.x 　

Neurotoxicity of methylglyxal and 3-Deoxyglycose on cultured cortical neurons : Synergism between glycation and oxidative stress, possibly involved in neurodegnerative diseases.

Neurosci letter

Advanced glycation end products potentiate human platelet aggregation in vitro : Possible role of oxdative stress.

Biochem Biophys Res Commun

Rapid formation of advanced glycation end products following vascular injury in euglycemic rat carotid artery : Role of oxidative stress.

Circulation Research

Stress carbonyl(]E85EE[) et complications a long terme de I' ur(]E85EE[)mie, in ACTUALIT(]E85D8[)S N(]E85D8[)PHROLOGIQUES JEAN HAMBURGER. H(]E87C7[)PITAL NECKER 1998(eds. Grundfeld JP, Bach JF, Kreis H)

M(]E85EE[)decine-Sciences Flammarion.　247-253

The receptor for advanced glycation end-products(RAGE)is a central mediator of the interaction of AGE-b2microglobulin with human mononuclearphagocytes via an oxidant-sensitive pathway : implications for the pathogenesis of dialysis-related amyloidosis.

J Clin Invest　(98)　1088-1094

"Carbonyl Stress"and long-term uremic complications.

Advanced in Nephrology