Details of the Researcher

PHOTO

Shigenori Kanno
Section
Graduate School of Medicine
Job title
Associate Professor
Degree

  • 博士（医学）（東北大学）

e-Rad No.
00596645

Research History 8

  • 2023/04 - Present
    Tohoku University Graduate School of Medicine　Department of Behavioral Neurology and Cogntive Neuroscience　Associate professor

  • 2018/07 - 2023/03
    Tohoku University Graduate School of Medicine　Department of Behavioral Neurology and Cogntive Neuroscience　Lecturer

  • 2012/04 - 2018/06
    South Miyagi Medical Center　Department of Neurology

  • 2010/04 - 2012/03
    Tohoku University Graduate School of Medicine　Department of Behavioral Neurology and Cognitive Neuroscience　Assistant professor

  • 2005/04 - 2006/03
    National Hospital Organization Miyagi Hospital　Department of Neurology

  • 2004/04 - 2005/03
    Tohoku University Hospital　Department of Neurology

  • 2003/04 - 2004/03
    Tohoku Kosei Nenkin Hospital　Deparment of Neurology　Senior resident

  • 2001/04 - 2003/03
    Tohoku Kosei Nenkin Hospital　Resident

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Education 2

  • Tohoku University　Graduate School of Medicine

    2006/04 - 2010/03

  • Tohoku University　Faculty of Medicine　School of Medicine

    1995/04 - 2001/03

Committee Memberships 3

  • 日本正常圧水頭症学会　理事

    2023 - Present

  • 日本神経心理学会　評議員

    2022 - Present

  • 日本神経精神医学会　評議員

    2021 - Present

Professional Memberships 7

  • 日本神経心理学会

  • 日本神経精神医学会

  • 日本認知症学会

  • Hydrocephalus Society

  • THE JAPANESE SOCIETY OF NPH

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

  • JAPANESE SOCIETY OF NEUROLOGY

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Research Interests 6

  • Neuropsychology

  • Behavioral neurology

  • Idiopathic normal pressure hydrocephalus

  • Parkinson's disease

  • Temporal lobe epilepsy

  • Primary progressive aphasia

Research Areas 3

  • Life sciences / Rehabilitation science /

  • Life sciences / Neurology / Functional neuroimaging

  • Life sciences / Neurology / Neuropsychology

Papers 60

  1. Spatiotemporal dynamics of reading Kana (syllabograms) and Kanji (morphograms). International-journal Peer-reviewed

    Kazuto Katsuse, Kazuo Kakinuma, Shin-Ichiro Osawa, Shoko Ota, Hana Kikuchi, Ai Kawamura, Kazushi Ukishiro, Kazuyo Tanji, Nobuko Kawakami, Chifumi Iseki, Shigenori Kanno, Yuichiro Shirota, Masashi Hamada, Tatsushi Toda, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    NeuroImage　317　121316-121316　2025/06/07

    DOI： 10.1016/j.neuroimage.2025.121316 　

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    Reading engages complex neural networks integrating visual, phonological, and semantic information. The dual-stream model posits ventral and dorsal pathways for lexical and sublexical processing in the left hemisphere and is well-supported in alphabetic languages. However, its applicability to non-alphabetic scripts remains unclear. The Japanese writing system, comprising Kana (syllabograms) and Kanji (morphograms) with distinct orthographic, phonological, and semantic properties, provides a unique framework to investigate neural dissociation between phonological and orthographic-semantic processing. Previous studies suggest that Kanji relies on the ventral route for whole-word recognition and semantic processing, whereas Kana depends mainly on the dorsal route for phonological decoding via grapheme-to-phoneme conversion; however, their spatiotemporal dynamics remain unknown. Using high-gamma power analysis from electrocorticography recordings in 14 patients with epilepsy and subdural implants, we examined the spatiotemporal neural dynamics of Kana and Kanji reading. Participants completed a visual lexical decision task with Kana and Kanji words and pseudowords. Across 912 electrodes, differential high-gamma power analysis showed that Kanji activated bilateral occipitotemporal fusiform regions early (120-550 ms) and the left inferior temporal gyrus (150-240 ms). Conversely, Kana showed prolonged late activation (270-750 ms) in the left-lateralised superior temporal, supramarginal, and inferior frontal gyri, especially during pseudoword processing. These findings indicate that Kanji relies on bilateral ventral stream earlier, while Kana depends on the left dorsal stream, with slower processing reflecting the extra grapheme-to-phoneme conversion. This underscores the value of non-alphabetic languages in elucidating both universal and script-specific neural mechanisms, advancing a cross-linguistic understanding of the reading network.

  2. Case of Pure Agraphia in Kana and Romaji Without Sensorimotor Deficits After a Small Infarct of the Posterior Limb of the Internal Capsule Peer-reviewed

    Kazuto Katsuse, Akatsuki Kubota, Kazuo Kakinuma, Shoko Ota, Shigenori Kanno, Toshiyuki Kakumoto, Yuichiro Shirota, Masashi Hamada, Tatsushi Toda, Kyoko Suzuki

    Neurology　104　(7)　2025/04/08

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1212/wnl.0000000000210254 　

    ISSN： 0028-3878

    eISSN： 1526-632X

  3. Distinct cerebral perfusion patterns and linguistic profiles in Alzheimer’s disease-related primary progressive aphasia Peer-reviewed

    Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Nanayo Ogawa, Ai Kawamura, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Minoru Matsuda, Shigenori Kanno, Kyoko Suzuki

    Neurological Sciences　2025/03/24

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s10072-025-08100-2 　

    ISSN： 1590-1874

    eISSN： 1590-3478

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    Abstract Alzheimer’s disease (AD)-related primary progressive aphasia (PPA) exhibits considerable heterogeneity in clinical presentation and neuroimaging patterns. No studies have quantitatively assessed cerebral perfusion patterns or systematically evaluated the internal heterogeneity of linguistic and neuroimaging features in this population. This study aimed to investigate cerebral hypoperfusion patterns and elucidate their correlation with diverse linguistic features in patients with AD-related PPA using a data-driven approach. Eleven patients with AD-related PPA and 34 with non-AD-related PPA were categorized based on cerebrospinal fluid biomarkers, and their single-photon emission computed tomography (SPECT) data were analyzed. Cerebral hypoperfusion was assessed across 56 regions of interest (ROIs) covering the entire cerebral hemisphere. Sparse principal component (sPC) analysis was performed on the AD-related PPA group to identify distinct patterns of cerebral perfusion reduction and correlate these components with clinical assessments of linguistic abilities. AD-derived sPCs were identified, reflecting hypoperfusion patterns in the left temporoparietal, frontal, and temporal pole regions, corresponding to regions typically associated with logopenic, nonfluent, and semantic variants. In both AD-PPA and non-AD-PPA, the sPC corresponding to the anterior temporal region was associated with semantic comprehension deficits, whereas that corresponding to the frontal region was linked to nonfluent speech and Kana writing impairment. sPC-based hierarchical clustering revealed clusters corresponding to logopenic, nonfluent, and semantic variants, with the anomic subtype distinguished from logopenic PPA. AD-positive cases were distributed across these clusters, emphasizing AD-PPA heterogeneity. These findings suggested that AD-related PPA heterogeneity is reflected in distinct cerebral perfusion patterns, which correlate with varying linguistic deficits.

  4. The utility of customised tissue probability maps and templates for patients with idiopathic normal pressure hydrocephalus: a computational anatomy toolbox (CAT12) study. International-journal Peer-reviewed

    Shigenori Kanno, Junyan Liu, Ai Kawamura, Shoko Ota, Nobuko Kawakami, Chifumi Iseki, Kazuo Kakinuma, Shiho Matsubara, Kazuto Katsuse, Kazushi Sato, Takashi Takeuchi, Yoshitaka Tanaka, Hiroyasu Kodama, Tatsuo Nagasaka, Masahiro Sai, Hayato Odagiri, Mioko Saito, Kentaro Takanami, Shunji Mugikura, Kyoko Suzuki

    Fluids and barriers of the CNS　21　(1)　108-108　2024/12/30

    DOI： 10.1186/s12987-024-00611-y 　

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    BACKGROUND: Disproportionately enlarged subarachnoid space hydrocephalus (DESH) is one of the neuroradiological characteristics of idiopathic normal pressure hydrocephalus (iNPH), which makes statistical analyses of brain images difficult. This study aimed to develop and validate methods of accurate brain segmentation and spatial normalisation in patients with DESH by using the Computational Anatomy Toolbox (CAT12). METHODS: Two hundred ninety-eight iNPH patients with DESH and 25 healthy controls (HCs) who underwent cranial MRI were enrolled in this study. We selected the structural images of 169 patients to create customised tissue probability maps and diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) templates for patients with DESH (DESH-TPM and DESH-Template). The structural images of 38 other patients were used to evaluate the validity of the DESH-TPM and DESH-Template. DESH-TPM and DESH-Template were created using the 114 well-segmented images after the segmentation processing of CAT12. In the validation study, we compared the accuracy of brain segmentation and spatial normalisation among three conditions: customised condition, applying DESH-TPM and DESH-Template to CAT12 and patient images; standard condition, applying the default setting of CAT12 to patient images; and reference condition, applying the default setting of CAT12 to HC images. RESULTS: In the validation study, we identified three error types during segmentation. (1) The proportions of misidentifying the dura and/or extradural structures as brain structures in the customised, standard, and reference conditions were 10.5%, 44.7%, and 13.6%, respectively; (2) the failure rates of white matter hypointensity (WMH) cancellation in the customised, standard, and reference conditions were 18.4%, 44.7%, and 0%, respectively; and (3) the proportions of cerebrospinal fluid (CSF)-image deficits in the customised, standard, and reference conditions were 97.4%, 84.2%, and 28%, respectively. The spatial normalisation accuracy of grey and white matter images in the customised condition was the highest among the three conditions, especially in terms of superior convexity. CONCLUSIONS: Applying the combination of the DESH-TPM and DESH-Template to CAT12 could improve the accuracy of grey and white matter segmentation and spatial normalisation in patients with DESH. However, this combination could not improve the CSF segmentation accuracy. Another approach is needed to overcome this challenge.

  5. Oral applause sign in progressive supranuclear palsy. International-journal Peer-reviewed

    Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Ai Kawamura, Nanayo Ogawa, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki

    Cortex; a journal devoted to the study of the nervous system and behavior　2024/12/27

    DOI： 10.1016/j.cortex.2024.11.021 　

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    The applause sign (AS) is a recognized phenomenon observed in progressive supranuclear palsy (PSP) and other neurological conditions where individuals produce over three claps following a request to clap only thrice after a demonstration. In this study, we introduced a novel linguistic phenomenon termed the oral applause sign (OAS) associated with the AS. The OAS is characterized by increased repetition counts of Japanese repetitive onomatopoeic words, such as uttering "pata-pata-pata" instead of the expected "pata-pata." We identified this phenomenon in a patient with PSP exhibiting the AS and mild apraxia of speech. In addition, we developed the three-"pata" test, instructing the patient to say "pata" only thrice after demonstration without any semantic context, and reproduced the phenomenon of the additional increase of "pata" verbalization. The core feature of OAS is an inability to limit the count when repeating a small number of syllables continuously, similar to the inability to stop clapping. The shared features between the OAS and AS suggest potential overlapping mechanisms involving the dysfunction of the frontal lobe and subcortical structures and possibly, apraxia of speech. Considering that the OAS is triggered purely by repetition and unlikely to be affected by semantic content, it might be observable in Japanese and other languages. Longitudinal studies with larger cohorts across various neurodegenerative diseases and languages may elucidate the underlying mechanisms of the OAS and confirm its specificity to PSP, thus improving the generalizability and clinical relevance of the findings.

  6. Long-lasting pure topographical disorientation due to heading disorientation following left retrosplenial infarction: A report of two cases Peer-reviewed

    Nobuko Kawakami, Yuri Okada, Keisuke Morihara, Kazuto Katsuse, Kazuo Kakinuma, Shiho Matsubara, Shigenori Kanno, Kyoko Suzuki

    Brain and Cognition　181　106211-106211　2024/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.bandc.2024.106211 　

    ISSN： 0278-2626

  7. Levodopa-resistant parkinsonism developing after ventriculoperitoneal shunting for obstructive hydrocephalus and improving after endoscopic third ventriculostomy, with specific consideration of brainstem morphology: illustrative case. International-journal Peer-reviewed

    Yoshihiko Morisue, Shin-Ichiro Osawa, Kuniyasu Niizuma, Shigenori Kanno, Kyoko Suzuki, Hidenori Endo

    Journal of neurosurgery. Case lessons　8　(11)　2024/09/09

    DOI： 10.3171/CASE2429 　

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    BACKGROUND: Parkinsonism has been reported in patients with obstructive hydrocephalus (OH) following ventriculoperitoneal shunting (VPS). While levodopa works well, some cases are drug resistant. A few case series have reported that endoscopic third ventriculostomy (ETV) is beneficial, though its mechanism remains unclear. The use of a pathophysiology-reflected marker can aid in the diagnosis and treatment strategy. The authors report a case of parkinsonism due to OH after VPS that improved after ETV in a patient taking levodopa, which was subsequently discontinued. OBSERVATIONS: A 52-year-old man who had undergone VPS for OH caused by aqueductal stenosis with a tectal tumor presented with severe consciousness disturbance due to acute hydrocephalus and levodopa-refractory parkinsonism after multiple episodes of shunt malfunction. Magnetic resonance imaging showed an elevation of the floor of the third ventricle. ETV was performed to stabilize the pressure imbalance across the stenosis, and his parkinsonism symptoms improved after long-term rehabilitation, resulting in levodopa discontinuation. His pontomesencephalic angle, the angle between the anterior surface of the midbrain and upper surface of the pons in the midline of the sagittal plane, was significantly decreased. LESSONS: The focus in such cases should be on the essence of the pathophysiology for improving the symptoms rather than on easy-to-understand indicators such as ventricle size. https://thejns.org/doi/10.3171/CASE2429.

  8. Blake's pouch cyst-like imaging abnormalities in idiopathic normal pressure hydrocephalus Peer-reviewed

    Yumiko Saito, Toru Baba, Wataru Narita, Shigenori Kanno, Shunji Mugikura, Yasuko Tatewaki, Yoshiyuki Nishio, Osamu Iizuka, Yasuyuki Taki, Teiji Tominaga, Etsuro Mori, Kyoko Suzuki

    Brain Disorders　15　100153-100153　2024/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.dscb.2024.100153 　

    ISSN： 2666-4593

  9. A decade with anomic primary progressive aphasia Peer-reviewed

    Shoko Ota, Kazuo Kakinuma, Wataru Narita, Yoshiyuki Nishio, Nobuko Kawakami, Ayane Tamagake, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki

    eNeurologicalSci　35　100508-100508　2024/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.ensci.2024.100508 　

    ISSN： 2405-6502

  10. The grasp reflex in patients with idiopathic normal pressure hydrocephalus. International-journal Peer-reviewed

    Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-Ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

    Journal of neurology　2024/04/08

    DOI： 10.1007/s00415-024-12341-0 　

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    OBJECTIVE: To investigate the prevalence and intensity of grasp reflexes and to examine changes in these reflexes after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: We enrolled 147 patients with probable iNPH. A standard procedure was used to determine the presence of grasp reflexes, and the intensity of these reflexes was assessed using a four-category classification. Clinical rating scales and their correlation with grasp reflexes were also evaluated. Grasp reflexes were reassessed in 72 patients 1 year after surgery. RESULTS: We found that approximately 50.3% of patients with iNPH exhibited a positive grasp reflex. Among these patients, 69% exhibited bilateral positivity, while the remaining patients showed unilateral positivity. Furthermore, the intensity of the grasp reflex was significantly correlated with the severity of gait and with cognitive, urinary, motor, and behavioural symptoms. Surgical interventions led to a reduction (41.7%) or maintenance (30.6%) of the reflex intensity in 72.3% of iNPH patients. The changes in reflex intensity showed significant positive correlations with changes in the number of steps of the Timed Up and Go test and Trail Making Test-A scores but not with changes in total scores on the iNPH Grading Scale. CONCLUSION: This retrospective study identified grasp reflexes as a highly prevalent phenomenon in patients with iNPH. These reflexes can assist in evaluating the severity of various symptoms, including cognitive, gait, urinary, motor and emotional symptoms.

  11. [Preoperative Predictors of Outcomes of Cerebrospinal Fluid Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus].

    Shigenori Kanno, Kyoko Suzuki

    Brain and nerve = Shinkei kenkyu no shinpo　76　(2)　167-173　2024/02

    DOI： 10.11477/mf.1416202579 　

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    The disproportionately enlarged subarachnoid space hydrocephalus (DESH) findings on cranial images are useful to predict cerebrospinal fluid (CSF) shunt responsiveness to some extent in patients with idiopathic normal-pressure hydrocephalus (iNPH). However, recent studies show that patients with iNPH often have concomitant Alzheimer's or Lewy body disease regardless of DESH findings, which may be associated with poor outcomes of CSF shunt surgery. Moreover, long-term outcomes after CSF shunt surgery in patients with iNPH, which is one of the most important issues to be addressed for effective treatment of iNPH, remain unknown.

  12. Ventriculoperitoneal Shunt Failure 3-year after Shunt Surgery Caused by Migration of Detached Ventricular Catheter into the Cranium: A Case Study of Idiopathic Normal-pressure Hydrocephalus Peer-reviewed

    Kazuo KAKINUMA, Keisuke MORIHARA, Yoshiteru SHIMODA, Nobuko KAWAKAMI, Shigenori KANNO, Mayuko OTOMO, Teiji TOMINAGA, Kyoko SUZUKI

    NMC Case Report Journal　10　9-14　2023/12/31

    Publisher: Japan Neurosurgical Society

    DOI： 10.2176/jns-nmc.2022-0162 　

    eISSN： 2188-4226

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    Idiopathic normal-pressure hydrocephalus (iNPH) is a neurological disorder that typically presents with gait disturbance, cognitive impairment, and urinary incontinence. Although most patients respond to cerebrospinal-fluid shunting, some do not react well because of shunt failure. A 77-year-old female with iNPH underwent ventriculoperitoneal shunt implantation, and her gait impairment, cognitive dysfunction, and urge urinary incontinence improved. However, 3 years after shunting (at the age of 80), her symptoms gradually recurred for 3 months and she did not respond to shunt valve adjustment. Imaging studies revealed that the ventricular catheter detached from the shunt valve and migrated into the cranium. With immediate revision of the ventriculoperitoneal shunt, her gait disturbance, cognitive dysfunction, and urinary incontinence improved. When a patient whose symptoms have been relieved by cerebrospinal-fluid shunting experiences an exacerbation, it is important to suspect shunt failure, even if many years have passed since the surgery. Identifying the position of the catheter is crucial to determine the cause of shunt failure. Prompt shunt surgery for iNPH can be beneficial, even in elderly patients.

  13. Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis Peer-reviewed

    Shunji Mugikura, Naoko Mori, Miyeong Gang, Shigenori Kanno, Kazutaka Jin, Shin-Ichiro Osawa, Nobukazu Nakasato, Kei Takase

    Journal of Clinical Imaging Science　13　38-38　2023/12/22

    Publisher: Scientific Scholar

    DOI： 10.25259/jcis_77_2023 　

    ISSN： 2156-7514

    eISSN： 2156-5597

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    Objectives: To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides. Material and Methods: Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox. Results: Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions. Conclusion: By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.

  14. 発症早期から発話量低下と反響言語が顕著であった原発性非流暢性失語の1例

    小川 七世, 三田 晃裕, 鳥居 良太, 太田 祥子, 稲富 雄一郎, 森原 啓介, 山下 史匡, 菅野 重範, 鈴木 匡子

    臨床神経心理　34　17-25　2023/12

    Publisher: 東北神経心理懇話会

    ISSN： 1344-0292

    eISSN： 2758-0156

  15. 意図により悪化する着座障害を示した右頭頂後頭葉皮質下出血の一例

    勝瀬 一登, 柿沼 一雄, 森原 啓介, 松原 史歩, 川上 暢子, 川村 藍, 太田 祥子, 菅野 重範, 平山 和美, 鈴木 匡子

    臨床神経心理　34　27-27　2023/12

    Publisher: 東北神経心理懇話会

    ISSN： 1344-0292

    eISSN： 2758-0156

  16. Fluctuations in Upper and Lower Body Movement during Walking in Normal Pressure Hydrocephalus and Parkinson's Disease Assessed by Motion Capture with a Smartphone Application, TDPT-GT. International-journal

    Chifumi Iseki, Shou Suzuki, Tadanori Fukami, Shigeki Yamada, Tatsuya Hayasaka, Toshiyuki Kondo, Masayuki Hoshi, Shigeo Ueda, Yoshiyuki Kobayashi, Masatsune Ishikawa, Shigenori Kanno, Kyoko Suzuki, Yukihiko Aoyagi, Yasuyuki Ohta

    Sensors (Basel, Switzerland)　23　(22)　2023/11/18

    DOI： 10.3390/s23229263 　

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    We aimed to capture the fluctuations in the dynamics of body positions and find the characteristics of them in patients with idiopathic normal pressure hydrocephalus (iNPH) and Parkinson's disease (PD). With the motion-capture application (TDPT-GT) generating 30 Hz coordinates at 27 points on the body, walking in a circle 1 m in diameter was recorded for 23 of iNPH, 23 of PD, and 92 controls. For 128 frames of calculated distances from the navel to the other points, after the Fourier transforms, the slopes (the representatives of fractality) were obtained from the graph plotting the power spectral density against the frequency in log-log coordinates. Differences in the average slopes were tested by one-way ANOVA and multiple comparisons between every two groups. A decrease in the absolute slope value indicates a departure from the 1/f noise characteristic observed in healthy variations. Significant differences in the patient groups and controls were found in all body positions, where patients always showed smaller absolute values. Our system could measure the whole body's movement and temporal variations during walking. The impaired fluctuations of body movement in the upper and lower body may contribute to gait and balance disorders in patients.

  17. Auditory phonological identification impairment in primary progressive aphasia Peer-reviewed

    Nobuko Kawakami, Shigenori Kanno, Shoko Ota, Keisuke Morihara, Nanayo Ogawa, Kyoko Suzuki

    Cortex　168　130-142　2023/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.cortex.2023.08.007 　

    ISSN： 0010-9452

  18. Primary Progressive Aphasia and Hearing Impairment：with a Case Report Invited

    Nobuko Kawakami, Shigenori Kanno

    Higher Brain Function Research　43　(2)　161-165　2023/06/30

    Publisher: Japan Society for Higher Brain Dysfunction

    DOI： 10.2496/hbfr.43.161 　

    ISSN： 1348-4818

    eISSN： 1880-6554

  19. Olfactory Dysfunction, an Often Neglected Symptom of Hydrocephalus: Experience from a Case of Late-Onset Idiopathic Aqueductal Stenosis Peer-reviewed

    Naoya Yamazaki, Takafumi Hasegawa, Kensuke Ikeda, Ako Miyata, Shin-ichiro Osawa, Kuniyasu Niizuma, Shigenori Kanno, Teiji Tominaga, Masashi Aoki

    Case Reports in Neurology　41-47　2023/03/01

    Publisher: S. Karger AG

    DOI： 10.1159/000529532 　

    eISSN： 1662-680X

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    Disturbance of smell is often accompanied with common neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases. In addition, patients with head trauma, intracranial tumors, and hydrocephalus can also develop olfactory dysfunction, and some of which can improve with treatment of the underlying disease. In clinical practice, few patients complain of smell disturbances, thus olfactory dysfunction is often overshadowed by visible motor symptoms. Herein, we report a case of late-onset idiopathic aqueductal stenosis, a rare form of adult-onset hydrocephalus in which olfactory dysfunction and gait disturbance was markedly improved after endoscopic ventriculostomy. This case report is expected to make more physicians aware that hydrocephalus can cause olfactory dysfunction and that it can be corrected postoperatively. Furthermore, in addition to motor and neuropsychological function, olfactory function test might be useful for functional assessment before and after surgical treatment of hydrocephalus.

  20. 症例報告 プロソディー型原発性進行性発語失行の1例-apraxia of speech rating scale-3(ASRS-3)を用いた発語失行の評価 Peer-reviewed

    小川 七世, 太田 祥子, 長谷川 康博, 八鍬 央子, 菅野 重範, 鈴木 匡子

    言語聴覚研究　19　(4)　348-355　2022/12/15

    Publisher: 株式会社医学書院

    DOI： 10.11477/mf.6001200399 　

    ISSN： 1349-5828

  21. Mirror writing and cortical hypometabolism in Parkinson’s disease International-journal Peer-reviewed

    Mayumi Shinohara, Kayoko Yokoi, Kazumi Hirayama, Shigenori Kanno, Yoshiyuki Hosokai, Yoshiyuki Nishio, Toshiyuki Ishioka, Mika Otsuki, Atsushi Takeda, Toru Baba, Masashi Aoki, Takafumi Hasegawa, Akio Kikuchi, Wataru Narita, Etsuro Mori, Kyoko Suzuki

    PLOS ONE　17　(12)　e0279007-e0279007　2022/12/14

    Publisher: Public Library of Science (PLoS)

    DOI： 10.1371/journal.pone.0279007 　

    eISSN： 1932-6203

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    Mirror writing (MW) is the production of individual letters, words, or word strings in the reverse direction. Parkinson’s disease (PD) is a progressive neurodegenerative disorder, and high MW rates have been reported in patients with PD. Thus, the present study sought to identify the factors that cause MW in patients with PD. We examined the frequency of MW in patients with PD and investigated the area of the brain where such frequency inversely correlates with reduced regional cerebral metabolic rates of glucose (rCMRglc). We also examined whether this area satisfied the motor and visual monitoring hypotheses of MW that have been presented in previous studies. Thirty-six subjects with idiopathic PD and 23 healthy controls were included in the study. We asked the participants to write down words, numerals, and sentences from left to right using their dominant and non-dominant hands. Patients with PD underwent an 18F-fluorodeoxyglucose positron emission tomography scan to measure the rCMRglc. Neither the patients with PD nor the healthy subjects exhibited MW in the use of the right hand. In the use of the left hand, MW occurred in 15 of the 36 patients with PD, but in none of the healthy controls. The right intraparietal sulcus was identified as the area where rCMRglc was inversely correlated with the number of left–right reversed characters. Previous functional imaging studies have suggested that the right superior parietal cortex and intraparietal sulcus play an important role in recognizing left–right reversed letters. Therefore, dysfunction in the intraparietal sulcus may hinder the recognition of left–right reversed characters, resulting in MW. Consequently, our findings in patients with PD are consistent with the visual-monitoring hypothesis of MW.

  22. Dyslexia and dysgraphia of primary progressive aphasia in Chinese: A systematic review Peer-reviewed

    Junyan Liu, Shoko Ota, Nobuko Kawakami, Shigenori Kanno, Kyoko Suzuki

    Frontiers in Neurology　13　2022/12/06

    Publisher: Frontiers Media SA

    DOI： 10.3389/fneur.2022.1025660 　

    eISSN： 1664-2295

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    Introduction Currently, little is known about Chinese-speaking primary progressive aphasia (PPA) patients compared to patients who speak Indo-European languages. We examined the demographics and clinical manifestations, particularly reading and writing characteristics, of Chinese patients with PPA over the last two decades to establish a comprehensive profile and improve diagnosis and care. Methods We reviewed the demographic features, clinical manifestations, and radiological features of Chinese-speaking PPA patients from 56 articles published since 1994. We then summarized the specific reading and writing errors of Chinese-speaking patients. Results The average age of onset for Chinese-speaking patients was in their early 60's, and there were slightly more male patients than female patients. The core symptoms and images of Chinese-speaking patients were similar to those of patients who speak Indo-European languages. Reading and writing error patterns differed due to Chinese's distinct tone and orthography. The types of reading errors reported in Chinese-speaking patients with PPA included tonal errors, regularization errors, visually related errors, semantic errors, phonological errors, unrelated errors, and non-response. Among these errors, regularization errors were the most common in semantic variant PPA, and tonal errors were specific to Chinese. Writing errors mainly consisted of non-character errors (stroke, radical/component, visual, pictograph, dyskinetic errors, and spatial errors), phonologically plausible errors, orthographically similar errors, semantic errors, compound word errors, sequence errors, unrelated errors, and non-response. Conclusion This paper provides the latest comprehensive demographic information and unique presentations on the reading and writing of Chinese-speaking patients with PPA. More detailed studies are needed to address the frequency of errors in reading and writing and their anatomical substrates.

  23. Buccofacial apraxia in primary progressive aphasia Peer-reviewed

    Keisuke Morihara, Shoko Ota, Kazuo Kakinuma, Nobuko Kawakami, Yuichi Higashiyama, Shigenori Kanno, Fumiaki Tanaka, Kyoko Suzuki

    Cortex　158　61-70　2022/11/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.cortex.2022.10.010 　

    ISSN： 0010-9452

  24. Risk factors for unfavourable outcomes after shunt surgery in patients with idiopathic normal-pressure hydrocephalus International-journal Peer-reviewed

    Erena Kobayashi, Shigenori Kanno, Nobuko Kawakami, Wataru Narita, Makoto Saito, Keiko Endo, Masaki Iwasaki, Tomohiro Kawaguchi, Shigeki Yamada, Kazunari Ishii, Hiroaki Kazui, Masakazu Miyajima, Masatsune Ishikawa, Etsuro Mori, Teiji Tominaga, Fumiaki Tanaka, Kyoko Suzuki

    Scientific Reports　12　(1)　13921-13921　2022/08/17

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-022-18209-5 　

    eISSN： 2045-2322

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    Abstract A number of vascular risk factors (VRFs) have been reported to be associated with idiopathic normal-pressure hydrocephalus (iNPH), but it remains unclear whether these VRFs are related to patient outcomes after shunt surgery. Therefore, we investigated the risk factors for unfavourable outcomes after shunt surgery in iNPH patients using two samples from Tohoku University Hospital and from a multicentre prospective trial of lumboperitoneal (LP) shunt surgery for patients with iNPH (SINPHONI-2). We enrolled 158 iNPH patients. We compared the prevalence of VRFs and clinical measures between patients with favourable and unfavourable outcomes and identified predictors of unfavourable outcomes using multivariate logistic regression analyses. The presence of hypertension, longer disease duration, more severe urinary dysfunction, and a lower Evans’ index were predictors of unfavourable outcomes after shunt surgery. In addition, hypertension and longer disease duration were also predictors in patients with independent walking, and a lower Evans’ index was the only predictor in patients who needed assistance to walk or could not walk. Our findings indicate that hypertension is the only VRF related to unfavourable outcomes after shunt surgery in iNPH patients. Larger-scale studies are needed to elucidate the reason why hypertension can affect the irreversibility of symptoms after shunt placement.

  25. Case Report: Semantic Variant Primary Progressive Aphasia With Impaired Verbal Word Discrimination Peer-reviewed

    Nobuko Kawakami, Ayumi Morita, Shigenori Kanno, Nanayo Ogawa, Kazuo Kakinuma, Yumiko Saito, Erena Kobayashi, Wataru Narita, Kyoko Suzuki

    Frontiers in Neurology　13　2022/06/16

    Publisher: Frontiers Media SA

    DOI： 10.3389/fneur.2022.873735 　

    eISSN： 1664-2295

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    Some patients with primary progressive aphasia (PPA) present with various types of hearing deficits. Research on the auditory function and speech sounds in PPA, including temporal, phonemic, and prosodic processing, revealed impairment in some of these auditory processes. Many patients with PPA who present with impaired word recognition subsequently developed non-fluent variant PPA. Herein, we present a patient with semantic variant PPA (svPPA) who demonstrated impaired verbal word discrimination. Audiological examinations revealed normal auditory brainstem responses and slightly impaired pure-tone perception. By contrast, verbal word discrimination and monosyllable identification were impaired, and temporal auditory acuity deteriorated. Analyses of brain magnetic resonance images revealed a significant decrease in the gray matter volume in bilateral superior temporal areas, predominantly on the left, compared with those of patients with typical svPPA, which appeared to be associated with impaired word recognition in our patient.

  26. Do patients with auditory processing disorder (APD) present with only symptoms associated with auditory dysfunction? Two cases of adult patients with APD.

    菅野重範, 太田祥子, 親富祖まりえ, 佐々木志保, 川瀬哲明, 鈴木匡子

    臨床神経心理　33　25-34　2022

    ISSN： 1344-0292

  27. Reduced default mode network connectivity relative to white matter integrity is associated with poor cognitive outcomes in patients with idiopathic normal pressure hydrocephalus International-journal Peer-reviewed

    Shigenori Kanno, Kun-ichi Ogawa, Hiroaki Kikuchi, Masako Toyoshima, Nobuhito Abe, Kazushi Sato, Koichi Miyazawa, Ryuji Oshima, Satoru Ohtomo, Hiroaki Arai, Satoshi Shibuya, Kyoko Suzuki

    BMC Neurology　21　(1)　353　2021/09

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12883-021-02389-0 　

    eISSN： 1471-2377

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    <title>Abstract</title><sec> <title>Background</title> The aim of this study was to investigate whether default mode network (DMN) connectivity and brain white matter integrity at baseline were associated with severe cognitive impairments at baseline and poor cognitive outcomes after shunt placement in patients with idiopathic normal pressure hydrocephalus (iNPH). </sec><sec> <title>Methods</title> Twenty consecutive patients with iNPH whose symptoms were followed for 6 months after shunt placement and 10 healthy controls (HCs) were enrolled. DMN connectivity and brain white matter integrity at baseline in the patients with iNPH and HCs were detected by using resting-state functional magnetic resonance imaging (MRI) with independent component analysis and diffusion tensor imaging, respectively, and these MRI indexes were compared between the patients with iNPH and HCs. Performance on neuropsychological tests for memory and executive function and on the gait test was assessed in the patients with iNPH at baseline and 6 months after shunt placement. We divided the patients with iNPH into the relatively preserved and reduced DMN connectivity groups using the MRI indexes for DMN connectivity and brain white matter integrity, and the clinical measures were compared between the relatively preserved and reduced DMN connectivity groups. </sec><sec> <title>Results</title> Mean DMN connectivity in the iNPH group was significantly lower than that in the HC group and was significantly positively correlated with Rey auditory verbal learning test (RAVLT) immediate recall scores and frontal assessment battery (FAB) scores. Mean fractional anisotropy of the whole-brain white matter skeleton in the iNPH group was significantly lower than that in the HC group. The reduced DMN connectivity group showed significantly worse performance on the RAVLT at baseline and significantly worse improvement in the RAVLT immediate recall and recognition scores and the FAB scores than the preserved DMN connectivity group. Moreover, the RAVLT recognition score highly discriminated patients with relatively preserved DMN connectivity from those with relatively reduced DMN connectivity. </sec><sec> <title>Conclusions</title> Our findings indicated that iNPH patients with reduced DMN connectivity relative to the severity of brain white matter disruption have severe memory deficits at baseline and poorer cognitive outcomes after shunt placement. However, further larger-scale studies are needed to confirm these findings. </sec>

  28. Improvement in callosal disconnection syndrome with recovery of callosal connectivity. International-journal Peer-reviewed

    Keisuke Morihara, Kazuo Kakinuma, Erena Kobayashi, Nobuko Kawakami, Wataru Narita, Shigenori Kanno, Fumiaki Tanaka, Kyoko Suzuki

    Neurocase　27　(3)　1-9　2021/08/09

    DOI： 10.1080/13554794.2021.1959935 　

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    Recent advancements in radiological techniques have enabled the observation of the topographic distribution of the human corpus callosum. However, its functional connectivity remains to be elucidated. The symptoms of callosal disconnection syndrome (CDS) can potentially reveal the functional connections between the cerebral hemispheres. Herein, we report a patient with CDS, whose callosal lesion was restricted to the posterior midbody, isthmus, and an anterior part of the dorsal splenium. A 53-year-old right-handed woman demonstrated CDS following cerebral infarction associated with subarachnoid hemorrhage. She exhibited CDS including ideomotor apraxia, and tactile anomia with the left hand, cross-replication of hand postures, cross-localization of the fingers, and constructional impairment with the right hand. Six months after onset, the left-handed ideomotor apraxia on imitation improved, but that to command did not, which indicated the difference in the nature of the transcallosal connections between ideomotor apraxia on imitation and ideomotor apraxia to command. Longitudinal CDS observation and corpus callosum tractography will prove useful in expanding our understanding of the nature of the organization of interhemispheric information transference.

  29. Facial memory ability and self-awareness in patients with temporal lobe epilepsy after anterior temporal lobectomy. International-journal Peer-reviewed

    Hiroaki Hosokawa, Shigenori Kanno, Yoshiyuki Nishio, Iori Kawasaki, Kazumi Hirayama, Atsuko Sunaga, Naotake Shoji, Masaki Iwasaki, Nobukazu Nakasato, Teiji Tominaga, Kyoko Suzuki

    PloS one　16　(4)　e0248785　2021/04

    DOI： 10.1371/journal.pone.0248785 　

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    Anterior temporal lobectomy (ATL) is the most common surgical treatment for drug-resistant temporal lobe epilepsy (TLE). Right ATL has been reported to reduce facial memory ability in patients with TLE, as indicated by poor performance on the Warrington Recognition Memory Test for Faces (RMF), which is commonly used to evaluate visual memory in these patients. However, little is known about whether patients with TLE exhibit difficulties in identifying faces in daily life after ATL. The aim of this study was to investigate facial memory ability and self-awareness of face identification difficulties in patients with TLE after ATL. Sixteen patients with TLE after right ATL, 14 patients with TLE after left ATL, and 29 healthy controls were enrolled in this study. We developed the multiview face recognition test (MFRT), which comprises a learning phase (one or three frontal face images without external facial feature information) and a recognition phase (frontal, oblique, or noise-masked face images). Facial memory abilities were examined in all participants using the MFRT and RMF, and self-awareness of difficulties in face identification was evaluated using the 20-item prosopagnosia index (PI20), which has been widely used to assess developmental prosopagnosia. The MFRT performance in patients with TLE after ATL was significantly worse than that in healthy controls regardless of the resected side, whereas the RMF scores in patients with TLE were significantly worse than those in healthy controls only after right ATL. The MFRT performance in patients with TLE after both left and right ATL was more influenced by working memory load than that in healthy controls. The PI20 scores revealed that patients with TLE after left ATL were aware of their difficulties in identifying faces. These findings suggest that patients with TLE not only after right ATL but also after left ATL might have difficulties in face identification.

  30. 特発性正常圧水頭症診療Up to Date 特発性正常圧水頭症の鑑別診断

    菅野重範

    老年精神医学雑誌　32　(3)　311-319　2021

    ISSN： 0915-6305

  31. The clinical features of logopenic progressive aphasia (2020 version)

    Nanaoyo Ogawa, Shigenori Kanno, Wataru Narita, Kyoko Suzuki

    神経心理学　37　(3)　152-163　2021

    ISSN： 0911-1085

  32. Echolalia in patients with primary progressive aphasia. International-journal Peer-reviewed

    Shoko Ota, Shigenori Kanno, Ayumi Morita, Wataru Narita, Nobuko Kawakami, Kazuo Kakinuma, Yumiko Saito, Erena Kobayashi, Toru Baba, Osamu Iizuka, Yoshiyuki Nishio, Minoru Matsuda, Hayato Odagiri, Keiko Endo, Kentaro Takanami, Etsuro Mori, Kyoko Suzuki

    European journal of neurology　28　(4)　1113-1122　2020/12/11

    DOI： 10.1111/ene.14673 　

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    OBJECTIVE: This study aimed to examine echolalia and its related symptoms and brain lesions in primary progressive aphasia (PPA). METHODS: Forty-five patients with PPA were included: 19 non-fluent/agrammatic variant PPA (nfvPPA), 5 semantic variant PPA, 7 logopenic variant PPA, and 14 unclassified PPA patients. We detected echolalia in unstructured conversations. An evaluation of language function and the presence of parkinsonism, grasp reflex, imitation behaviour, and disinhibition were assessed. We also measured regional cerebral blood flow (rCBF) using single-photon emission computed tomography. RESULTS: Echolalia was observed in 12 nfvPPA and 2 unclassified PPA patients. All patients showed mitigated echolalia. We compared nfvPPA patients with echolalia (echolalia group) to those without echolalia (non-echolalia group). The median age of the echolalia group was significantly lower than that of the non-echolalia group, and the echolalia group showed a significantly worse auditory comprehension performance than the non-echolalia group. In contrast, the performance of repetition tasks was not different between the two groups. The prevalence of imitation behaviour in the echolalia group was significantly higher than that in the non-echolalia group. The rCBFs in the bilateral pre-supplementary motor area and bilateral middle cingulate cortex in the echolalia group were significantly lower than those in the non-echolalia group. CONCLUSIONS: These findings suggest that echolalia is characteristic of nfvPPA patients with preserved repetition and impaired comprehension. Reduced inhibition of the medial frontal cortex with release activity of the anterior perisylvian area account for the emergence of echolalia.

  33. Neural substrates underlying progressive micrographia in Parkinson's disease International-journal Peer-reviewed

    Shigenori Kanno, Mayumi Shinohara, Kasumi Kanno, Yukihiro Gomi, Makoto Uchiyama, Yoshiyuki Nishio, Toru Baba, Yoshiyuki Hosokai, Atsushi Takeda, Hiroshi Fukuda, Etsuro Mori, Kyoko Suzuki

    Brain and Behavior　10　(8)　e01669　2020/06/18

    Publisher: Wiley

    DOI： 10.1002/brb3.1669 　

    ISSN： 2162-3279

    eISSN： 2162-3279

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    INTRODUCTION: The neural substrates associated with the development of micrographia remain unknown. We aimed to elucidate the neural substrates underlying micrographia in Parkinson's disease (PD) patients. METHODS: Forty PD patients and 20 healthy controls underwent handwriting tests that involved free writing and copying. We measured the size of each letter and the resting cerebral glucose metabolic rate of the PD patients and another group of age- and sex-matched 14 healthy controls (HCs), who had not participated in the writing tests, using resting-state 18F-fluorodeoxyglucose positron emission tomography. RESULTS: In the PD patients, the prevalence of consistent micrographia (CM) associated with free writing was 2.5% for both tasks. Alternatively, the prevalence of progressive micrographia (PM) was 15% for free writing and 17.5% for copying. In the PD patients, there was no significant difference in the letter sizes between these tasks, whereas the variability of the letter sizes for copying was significantly different from that for free writing. The means and decrements in letter sizes in either task were not significantly correlated with the severity of brady/hypokinesia in the PD patients. For free writing, the PD patients with PM showed glucose hypometabolism in the anterior part of the right middle cingulate cortex, including the rostral cingulate motor area, compared with those without PM. For copying, the PD patients with PM showed glucose hypometabolism in the right superior occipital gyrus, including V3A, compared with those without PM. CONCLUSIONS: These findings suggest that PM in free writing in PD patients is caused by the difficulty of monitoring whether the actual handwriting movements are desirable for maintaining letter size during self-paced handwriting. By contrast, PM in copying in PD patients is evoked by a lack of visual information about the personal handwriting and hand motions that are used as cues for maintaining letter sizes.

  34. A change in brain white matter after shunt surgery in idiopathic normal pressure hydrocephalus: a tract-based spatial statistics study. International-journal Peer-reviewed

    Shigenori Kanno, Makoto Saito, Tomohito Kashinoura, Yoshiyuki Nishio, Osamu Iizuka, Hirokazu Kikuchi, Masahito Takagi, Masaki Iwasaki, Shoki Takahashi, Etsuro Mori

    Fluids and barriers of the CNS　14　(1)　1-1　2017/01/30

    DOI： 10.1186/s12987-016-0048-8 　

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    BACKGROUND: The aim of this study was to elucidate changes in cerebral white matter after shunt surgery in idiopathic normal pressure hydrocephalus (INPH) using diffusion tensor imaging (DTI). METHODS: Twenty-eight consecutive INPH patients whose symptoms were followed for 1 year after shunt placement and 10 healthy control (HC) subjects were enrolled. Twenty of the initial 28 INPH patients were shunt-responsive (SR) and the other 8 patients were non-responsive (SNR). The cerebral white matter integrity was detected by assessing fractional anisotropy (FA) and mean diffusivity (MD). The mean hemispheric DTI indices and the ventricular sizes were calculated, and a map of these DTI indices was created for each subject. The DTI maps were analysed to compare preshunt INPH with HC and preshunt INPH with 1 year after shunt placement in each INPH group, using tract-based spatial statistics. We restricted analyses to the left hemisphere because of shunt valve artefacts. RESULTS: The ventricles became significantly smaller after shunt placement both in the SR and SNR groups. In addition, there was a significant interaction between clinical improvement after shunt and decrease in ventricular size. Although the hemispheric DTI indices were not significantly changed after shunt placement, there was a significant interaction between clinical improvement and increase in hemispheric MD. Compared with the HC group, FA in the corpus callosum and in the subcortical white matter of the convexity and the occipital cortex was significantly lower in SR at baseline, whereas MD in the periventricular and peri-Sylvian white matter was significantly higher in the SR group. Compared with the pre-operative images, the post-operative FA was only decreased in the corona radiata and only in the SR group. There were no significant regions in which DTI indices were altered after shunt placement in the SNR group. CONCLUSIONS: Brain white matter regions in which FA was decreased after shunt placement were in the corona radiata between the lateral ventricles and the Sylvian fissures. This finding was observed only in shunt-responsive INPH patients and might reflect the plasticity of the brain for mechanical pressure changes from the cerebrospinal fluid system.

  35. The Pareidolia Test: A Simple Neuropsychological Test Measuring Visual Hallucination-Like Illusions Peer-reviewed

    Yasuyuki Mamiya, Yoshiyuki Nishio, Hiroyuki Watanabe, Kayoko Yokoi, Makoto Uchiyama, Toru Baba, Osamu Iizuka, Shigenori Kanno, Naoto Kamimura, Hiroaki Kazui, Mamoru Hashimoto, Manabu Ikeda, Chieko Takeshita, Tatsuo Shimomura, Etsuro Mori

    PLOS ONE　11　(5)　e0154713　2016/05

    DOI： 10.1371/journal.pone.0154713 　

    ISSN： 1932-6203

  36. Callosal Disconnection Syndrome Associated with Relapsing Polychondritis Peer-reviewed

    Toru Baba, Shigenori Kanno, Tomomi Shijo, Yoshiyuki Nishio, Osamu Iizuka, Naoto Kamimura, Tomonori Ishii, Etsuro Mori

    INTERNAL MEDICINE　55　(9)　1191-1193　2016

    DOI： 10.2169/internalmedicine.55.5345 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  37. Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus Peer-reviewed

    Kotaro Hiraoka, Wataru Narita, Hirokazu Kikuchi, Toru Baba, Shigenori Kanno, Osamu Iizuka, Manabu Tashiro, Shozo Furumoto, Nobuyuld Okamura, Katsutoshi Furukawa, Hiroyuki Arai, Ren Iwata, Etsuro Mori, Kazuhiko Yanai

    JOURNAL OF THE NEUROLOGICAL SCIENCES　356　(1-2)　124-128　2015/09

    DOI： 10.1016/j.jns.2015.06.029 　

    ISSN： 0022-510X

    eISSN： 1878-5883

  38. Case of posterior reversible encephalopathy syndrome due to azathioprine Peer-reviewed

    Ryo Ogawa, Takanori Oikawa, Tomomi Shijo, Shigenori Kanno, Satoshi Shibuya, Hiroshi Mochizuki

    Clinical Neurology　55　(12)　936-939　2015

    Publisher: Societas Neurologica Japonica

    DOI： 10.5692/clinicalneurol.cn-000733 　

    ISSN： 0009-918X

  39. Pure word deafness due to a localization-related seizure: A case study Peer-reviewed

    Tomomi Shijo, Shigenori Kanno, Satoshi Shibuya, Takanori Oikawa, Ayumu Ohnuma, Hiroshi Mochizuki

    Clinical Neurology　54　(9)　726-731　2014

    Publisher: Societas Neurologica Japonica

    DOI： 10.5692/clinicalneurol.54.726 　

    ISSN： 0009-918X

  40. Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study Peer-reviewed

    Masahito Takagi, Yasushi Ishigaki, Kenji Uno, Shojiro Sawada, Junta Imai, Keizo Kaneko, Yutaka Hasegawa, Tetsuya Yamada, Ai Tokita, Kazumi Iseki, Shigenori Kanno, Yoshiyuki Nishio, Hideki Katagiri, Etsuro Mori

    BMC NEUROLOGY　13　76　2013/07

    DOI： 10.1186/1471-2377-13-76 　

    ISSN： 1471-2377

  41. 再発性多発軟骨炎による脳梁損傷の一例-右手が動くと左手も動く-

    工藤正子, 染谷浩美, 大部修治, 大友一樹, 戸枝美保, 菅原由恵, 及川崇紀, 四條友望, 菅野重範

    臨床神経心理　24　55-60　2013

    ISSN： 1344-0292

  42. Counting-backward test for executive function in idiopathic normal pressure hydrocephalus Peer-reviewed

    S. Kanno, M. Saito, A. Hayashi, M. Uchiyama, K. Hiraoka, Y. Nishio, K. Hisanaga, E. Mori

    ACTA NEUROLOGICA SCANDINAVICA　126　(4)　279-286　2012/10

    DOI： 10.1111/j.1600-0404.2012.01644.x 　

    ISSN： 0001-6314

  43. 特発性正常圧水頭症(iNPH)iNPHと高次脳機能障害

    菅野重範, 森悦朗

    Clinical Neuroscience　30　(4)　417-419　2012

    ISSN： 0289-0585

  44. Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study Peer-reviewed

    Toru Baba, Akio Kikuchi, Kazumi Hirayama, Yoshiyuki Nishio, Yoshiyuki Hosokai, Shigenori Kanno, Takafumi Hasegawa, Naoto Sugeno, Masatoshi Konno, Kyoko Suzuki, Shoki Takahashi, Hiroshi Fukuda, Masashi Aoki, Yasuto Itoyama, Etsuro Mori, Atsushi Takeda

    BRAIN　135　(Pt 1)　161-169　2012/01

    DOI： 10.1093/brain/awr321 　

    ISSN： 0006-8950

  45. A Validation Study of the Japanese Version of the Addenbrooke's Cognitive Examination-Revised. International-journal Peer-reviewed

    Dos Santos, Kawata KH, Hashimoto R, Nishio Y, Hayashi A, Ogawa N, Kanno S, Hiraoka K, Yokoi K, Iizuka O, Mori E

    Dementia and geriatric cognitive disorders extra　2　(1)　29-37　2012/01

    DOI： 10.1159/000336909 　

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    The aim of this study was to validate the Japanese version of the Addenbrooke's Cognitive Examination-Revised (ACE-R) [Mori: Japanese Edition of Hodges JR's Cognitive Assessment for Clinicians, 2010] designed to detect dementia, and to compare its diagnostic accuracy with that of the Mini-Mental State Examination. The ACE-R was administered to 85 healthy individuals and 126 patients with dementia. The reliability assessment revealed a strong correlation in both groups. The internal consistency was excellent (α-coefficient = 0.88). Correlation with the Clinical Dementia Rating sum of boxes score was significant (r(s) = -0.61, p < 0.001). The area under the curve was 0.98 for the ACE-R and 0.96 for the Mini-Mental State Examination. The cut-off score of 80 showed a sensitivity of 94% and a specificity of 94%. Like the original ACE-R and the versions designed for other languages, the Japanese version of the ACE-R is a reliable and valid test for the detection of dementia.

  46. White matter involvement in idiopathic normal pressure hydrocephalus: a voxel-based diffusion tensor imaging study Peer-reviewed

    Shigenori Kanno, Nobuhito Abe, Makoto Saito, Masahito Takagi, Yoshiyuki Nishio, Akiko Hayashi, Makoto Uchiyama, Risa Hanaki, Hirokazu Kikuchi, Kotaro Hiraoka, Hiroshi Yamasaki, Osamu Iizuka, Atsushi Takeda, Yasuto Itoyama, Shoki Takahashi, Etsuro Mori

    JOURNAL OF NEUROLOGY　258　(11)　1949-1957　2011/11

    DOI： 10.1007/s00415-011-6038-5 　

    ISSN： 0340-5354

  47. False item recognition in patients with Alzheimer&apos;s disease Peer-reviewed

    Nobuhito Abe, Toshikatsu Fujii, Yoshiyuki Nishio, Osamu Iizuka, Shigenori Kanno, Hirokazu Kikuchi, Masahito Takagi, Kotaro Hiraoka, Hiroshi Yamasaki, Hyunjoo Choi, Kazumi Hirayama, Mayumi Shinohara, Etsuro Mori

    NEUROPSYCHOLOGIA　49　(7)　1897-1902　2011/06

    DOI： 10.1016/j.neuropsychologia.2011.03.015 　

    ISSN： 0028-3932

  48. Is the midbrain involved in the manifestation of gait disturbance in idiopathic normal-pressure hydrocephalus? Peer-reviewed

    Kotaro Hiraoka, Hiroshi Yamasaki, Masahito Takagi, Makoto Saito, Yoshiyuki Nishio, Osamu Iizuka, Shigenori Kanno, Hirokazu Kikuchi, Etsuro Mori

    JOURNAL OF NEUROLOGY　258　(5)　820-825　2011/05

    DOI： 10.1007/s00415-010-5847-2 　

    ISSN： 0340-5354

  49. Cognitive profile of idiopathic normal pressure hydrocephalus. International-journal Peer-reviewed

    Saito M, Nishio Y, Kanno S, Uchiyama M, Hayashi A, Takagi M, Kikuchi H, Yamasaki H, Shimomura T, Iizuka O, Mori E

    Dementia and geriatric cognitive disorders extra　1　(1)　202-211　2011/01

    DOI： 10.1159/000328924 　

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    BACKGROUND/AIMS: Frontal lobe dysfunction is believed to be a primary cognitive symptom in idiopathic normal pressure hydrocephalus (iNPH); however, the neuropsychology of this disorder remains to be fully investigated. The objective of this study was to delineate a comprehensive profile of cognitive dysfunction in iNPH and evaluate the effects of cerebrospinal fluid (CSF) shunt surgery on cognitive dysfunction. METHODS: A total of 32 iNPH patients underwent neuropsychological testing of memory, attention, language, executive function, and visuoperceptual and visuospatial abilities. Of these 32 patients, 26 were reevaluated approximately 1 year following CSF shunt surgery. The same battery of tests was performed on 32 patients with Alzheimer's disease (AD) and 30 healthy elderly controls. RESULTS: The iNPH patients displayed baseline deficits in attention, executive function, memory, and visuoperceptual and visuospatial functions. Impairments of attention, executive function, and visuoperceptual and visuospatial abilities in iNPH patients were more severe than in those with AD, whereas the degree of memory impairment was comparable to that in AD patients. A significant improvement in executive function was observed following shunt surgery. CONCLUSION: Patients with iNPH are impaired in various aspects of cognition involving both 'frontal' executive functions and 'posterior cortical' functions. Shunt treatment can ameliorate executive dysfunction.

  50. Changes in the volumes of the brain and cerebrospinal fluid spaces after shunt surgery in idiopathic normal-pressure hydrocephalus Peer-reviewed

    Kotaro Hiraoka, Hiroshi Yamasaki, Masahito Takagi, Makoto Saito, Yoshiyuki Nishio, Osamu Iizuka, Shigenori Kanno, Hirokazu Kikuchi, Takeo Kondo, Etsuro Mori

    JOURNAL OF THE NEUROLOGICAL SCIENCES　296　(1-2)　7-12　2010/09

    DOI： 10.1016/j.jns.2010.06.021 　

    ISSN： 0022-510X

  51. 回転寿司を連濁せずに「かいてんすし」と音読するlogopenic progressive aphasia(LPA)の1例

    小川七世, 橋本竜作, 西尾慶之, 遠藤佳子, 菅野重範, 森悦朗

    臨床神経心理　21　49-56　2010

  52. 左聴放線の障害による聴覚認知障害-左被殻出血例による検討-

    槝之浦智仁, 菅野重範, 西尾慶之, 目黒祐子, 森悦朗, 渡邉裕志

    臨床神経心理　20　67-72　2009

    ISSN： 1344-0292

  53. 高次脳機能障害のすべて III.神経疾患と高次脳機能障害 2.認知症を生じる疾患 E.特発性正常圧水頭症

    菅野重範, 森悦朗

    月刊神経内科　68　116-122　2008

    ISSN： 0386-9709

  54. Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution Peer-reviewed

    Yusei Shiga, Katsuya Satoh, Tetsuyuki Kitamoto, Sigenori Kanno, Ichiro Nakashima, Shigeru Sato, Kazuo Fujihara, Hiroshi Takata, Keigo Nobukuni, Shigetoshi Kuroda, Hiroki Takano, Yoshitaka Umeda, Hidehiko Konno, Kunihiko Nagasato, Akira Satoh, Yoshito Matsuda, Mitsuru Hidaka, Hirokatsu Takahashi, Yasuteru Sano, Kang Kim, Takashi Konishi, Katsumi Doh-ura, Takeshi Sato, Kensuke Sasaki, Yoshikazu Nakamura, Masahito Yamada, Hidehiro Mizusawa, Yasuto Itoyama

    JOURNAL OF NEUROLOGY　254　(11)　1509-1517　2007/11

    DOI： 10.1007/s00415-007-0540-9 　

    ISSN： 0340-5354

  55. 左被殻出血による純粋失構音の1症例

    目黒祐子 , 渡邉裕志 , 菅野重範

    臨床神経心理　18　23-30　2007

  56. 脳梁無形性における半球間の情報伝達 －脳梁無形性に左後頭葉梗塞を合併した１例ー

    菅野重範, 鈴木匡子, 森悦朗, 佐藤輝幸, 澁谷聡, 及川崇紀, 望月廣, 永井弥志男

    臨床神経心理　18　51-56　2007

  57. 左前頭葉梗塞後にhyperlexiaを呈した1例

    深津玲子, 佐々木結花, 菅野重範, 上野彩

    臨床神経心理　17　65-69　2006

  58. 抗GAD抗体高値を呈し,小脳失調,前頭葉症状,側頭葉てんかん,I型糖尿病を合併した一症例

    菅野 重範, 長谷川 隆文, 竪山 真規, 志賀 裕正, 糸山 泰人, 高橋 和眞, 鈴木 匡子

    臨床神経心理　16　39-42　2005/12

    Publisher: 東北神経心理懇話会

    ISSN： 1344-0292

  59. Neuro-Behcet's disease presenting initially as mesiotemporal lesions mimicking herpes simplex encephalitis Peer-reviewed

    T Hasegawa, S Kanno, M Kato, K Fujihara, Y Shiga, Y Itoyama

    EUROPEAN JOURNAL OF NEUROLOGY　12　(8)　661-662　2005/08

    DOI： 10.1111/j.1468-1331.2005.01031.x 　

    ISSN： 1351-5101

  60. 見えるけれど分からない-連合型視覚性失認の一例-

    目黒祐子, 平山和美, 境信哉, 早坂順子, 菅野重範

    臨床神経心理　15　11-18　2004

    ISSN： 1344-0292

Show all ︎Show first 5

Misc. 106

  1. iNPHの鑑別/併存診断と脳神経外科医との診療連携 特発性正常圧水頭症と類似疾患との鑑別・併存アルゴリズム

    伊関 千書, 菅野 重範, 鈴木 匡子, 森 悦朗, 數井 裕光

    Dementia Japan　38　(4)　658-658　2024/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  2. 右大脳半球への超選択的Wadaテストによる半側空間無視の評価法の開発

    勝瀬 一登, 柿沼 一雄, 大沢 伸一郎, 浮城 一司, 菊地 花, 川村 藍, 齋藤 治仁, 太田 祥子, 伊関 千書, 菅野 重範, 戸田 達史, 遠藤 英徳, 中里 信和, 鈴木 匡子

    日本神経心理学会総会プログラム・予稿集　48回　104-104　2024/08

    Publisher: 日本神経心理学会

  3. 肢節運動失行があってもactive touchでは手指の動きに拙劣さを認めなかった大脳皮質基底核症候群の1例

    小川 七世, 松原 史歩, 伊関 千書, 勝瀬 一登, 齋藤 治仁, 川村 藍, 川上 暢子, 柿沼 一雄, 菅野 重範, 鈴木 匡子

    日本神経心理学会総会プログラム・予稿集　48回　110-110　2024/08

    Publisher: 日本神経心理学会

  4. 半盲視野に人物の複雑幻視を生じた左後頭葉梗塞の一例

    柿沼 一雄, 勝瀬 一登, 松原 史歩, 菊地 花, 齋藤 治仁, 太田 祥子, 川上 暢子, 伊関 千書, 菅野 重範, 鈴木 匡子

    日本神経心理学会総会プログラム・予稿集　48回　116-116　2024/08

    Publisher: 日本神経心理学会

  5. 認知症疾患の歩行障害に対するAI自動判別,ゆらぎ解析:iPhoneアプリTDPT-GTから

    伊関千書, 早坂達哉, 柳川漂太, 小森谷祐太, 鈴木渉, 深見忠典, 近藤敏行, 菅野重範, 鈴木匡子, 太田康之, 青柳幸彦, 山田茂樹

    Dementia Japan　38　(4)　2024

    ISSN： 1342-646X

  6. 特発性正常圧水頭症とパーキンソン病の歩行中の上肢および下肢運動のゆらぎ解析:iPhoneアプリモーションキャプチャを利用して

    伊関千書, 鈴木渉, 深見忠典, 山田茂樹, 近藤敏行, 星真行, 石川正恒, 菅野重範, 鈴木匡子, 太田康之

    日本正常圧水頭症学会プログラム・抄録集　25th　2024

  7. 特発性正常圧水頭症患者におけるアパシーの質的特徴の検討

    川村藍, 菅野重範, 小林良太, 川勝忍, 大庭輝, 井原一成, 川上暢子, 森原啓介, 森原啓介, 柿沼一雄, 松原史歩, 勝瀬一登, 勝瀬一登, 鈴木匡子

    高次脳機能研究　44　(1)　2024

    ISSN： 1348-4818

  8. 運動感覚障害を伴わず,純粋失書・タイピング障害のみを示した左内包後脚梗塞の症例

    勝瀬一登, 勝瀬一登, 久保田暁, 柿沼一雄, 太田祥子, 菅野重範, 角元利行, 代田悠一郎, 濱田雅, 戸田達史, 鈴木匡子

    高次脳機能研究　44　(1)　2024

    ISSN： 1348-4818

  9. 原発性進行性失語症における失文法の評価

    八鍬央子, 八鍬央子, 森原啓介, 川上暢子, 柿沼一雄, 松原史歩, 勝瀬一登, 勝瀬一登, 太田祥子, 小川七世, 川村藍, 菊地花, 菅野重範, 鈴木匡子

    高次脳機能研究　44　(1)　2024

    ISSN： 1348-4818

  10. シャント術後に浮動性めまいの消失を認めた特発性正常圧水頭症の1例

    松原 史歩, 柿沼 一雄, 勝瀬 一登, 森原 啓介, 川上 暢子, 菅野 重範, 鈴木 匡子

    臨床神経学　63　(4)　249-249　2023/04

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  11. 左脳梁膨大後域出血で純粋な道順障害が長期に継続した1例

    岡田 友里, 川上 暢子, 森原 啓介, 柿沼 一雄, 松原 史歩, 菅野 重範, 鈴木 匡子

    43　(1)　104-104　2023/03

  12. 原発性進行性失語症における書字障害の検討 非流暢/失文法型と意味型との比較

    太田 祥子, 菅野 重範, 川上 暢子, 森原 啓介, 柿沼 一雄, 松原 史歩, 勝瀬 一登, 稲富 雄一郎, 鈴木 匡子

    高次脳機能研究　43　(1)　40-40　2023/03

    Publisher: (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  13. 原発性進行性失語における環境音認知および関連機能の検討

    川上暢子, 菅野重範, 太田祥子, 小川七世, 鈴木匡子

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  14. 原発性進行性失語における動詞呼称と名詞呼称の解離-脳血流低下部位との関連-

    勝瀬一登, 勝瀬一登, 太田祥子, 柿沼一雄, 松原史歩, 川上暢子, 小川七世, 小川七世, 伊関千書, 戸田達史, 松田実, 松田実, 菅野重範, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　47th　2023

  15. 意味行動障害型前頭側頭型認知症(sbvFTD)の1例における相貌・物品認知と単語認知

    小川七世, 小川七世, 三田晃裕, 菅野重範, 勝瀬一登, 勝瀬一登, 山下史匡, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　47th　2023

  16. アルツハイマー病理を背景とする原発性進行性失語の多様性評価と分類

    勝瀬一登, 勝瀬一登, 柿沼一雄, 森原啓介, 森原啓介, 松原史歩, 川上暢子, 小川七世, 小川七世, 太田祥子, 戸田達史, 松田実, 松田実, 菅野重範, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　64th　2023

  17. 原発性進行性失語の聴覚および聴覚的音韻処理機能障害と関連脳領域の検討

    川上暢子, 太田祥子, 森原啓介, 菅野重範, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　64th　2023

  18. 発語失行と開鼻声を呈した進行性非流暢性失語の一例

    太田祥子, 川上暢子, 渡部聡, 松村邦也, 森田亜由美, 菅野重範, 森原啓介, 森原啓介, 柿沼一雄, 松原史歩, 勝瀬一登, 勝瀬一登, 松田実, 鈴木匡子

    日本言語聴覚学会(Web)　24th　2023

  19. 原発性進行性失語症における口舌顔面失行の臨床学的特徴と責任病巣について

    森原啓介, 太田祥子, 柿沼一雄, 川上暢子, 東山雄一, 菅野重範, 田中章景, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　63rd　2022

  20. 10年に渡り失語症を中心に緩徐に認知機能障害が進行したPPAの一例

    太田祥子, 柿沼一雄, 成田渉, 西尾慶之, 川上暢子, 玉懸綾音, 菅野重範, 森原啓介, 森原啓介, 松原史歩, 遠藤佳子, 松田実, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　46th　2022

  21. 特発性正常圧水頭症患者におけるシャント手術後の行動心理症状の改善に関する検討

    松村邦也, 菅野重範, 川上暢子, 小林絵礼奈, 柿沼一雄, 森原啓介, 松原史歩, 大田祥子, 川村藍, 遠藤佳子, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　46th　2022

  22. 経過とともに反響言語が顕著となった進行性非流暢性失語の2症例

    太田祥子, 森田亜由美, 成田渉, 成田渉, 川上暢子, 小林絵礼奈, 小林絵礼奈, 菅野重範, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　45th　2021

  23. 発語失行を伴う進行性非流暢性失語の臨床的特徴と脳機能低下部位

    太田祥子, 菅野重範, 森田亜由美, 成田渉, 川上暢子, 小林絵礼奈, 柿沼一雄, 遠藤佳子, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　44　101-101　2020/09

  24. 特発性正常圧水頭症患者におけるシャント術後の転帰不良因子の同定

    小林絵礼奈, 菅野重範, 成田渉, 田中章景, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　61　509-509　2020/08

  25. パーキンソン病における視覚性および触覚性の質感認知

    親富祖まりえ, 馬場徹, 川崎伊織, 成田渉, 菅野重範, 武田篤, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　43　217-217　2019/10

  26. 構音の歪みを伴わない進行性非流暢性失語の一例

    柿沼一雄, 成田渉, 齋藤裕美子, 森田亜由美, 小林絵礼奈, 川上暢子, 菅野重範, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　43　202-202　2019/10

  27. 時間的文脈の記憶障害を特徴とする“非”前脳基底部健忘の一例

    齋藤裕美子, 成田渉, 川上暢子, 小林絵礼奈, 柿沼一雄, 森田亜由美, 菅野重範, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　43　244-244　2019/10

  28. 軽度仮名音読障害の発症機序の検討

    遠藤佳子, 飯塚統, 菅野重範, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　43　158-158　2019/10

  29. Hypertension and severe urinary dysfunction are associated with poor outcomes after shunt surgery in idiopathic normal pressure hydrocephalus

    Erena Kobayashi, Shigenori Kanno, Wataru Narita, Kyoko Suzuki

    Hydrocephalus 2019 abstract book　2019/09

  30. 語音認知の障害を伴った意味性認知症の一例

    川上暢子, 柿沼一雄, 齋藤裕美子, 小林絵礼奈, 成田渉, 菅野重範, 鈴木匡子

    日本神経心理学会総会プログラム・予稿集　43rd　66　2019/07/31

  31. 原発性進行性失語を呈したレビー小体病の一例

    小林絵礼奈, 成田渉, 森田亜由美, 柿沼一雄, 齋藤裕美子, 川上暢子, 飯塚統, 菅野重範, 鈴木匡子

    臨床神経学　59　(1)　55-55　2019

    ISSN： 1882-0654

  32. ミトコンドリア神経性胃膓管系脳筋症の一例

    竹内洋平, 宮澤康一, 大嶋龍司, 菅野重範, 松原史歩, 澁谷聡, 村山圭

    臨床神経学(Web)　58　(8)　539(J‐STAGE)　2018

    ISSN： 1882-0654

  33. 四肢の筋痛,筋力低下を呈した顕微鏡的多発血管炎の一例

    高橋妙珠, 菅野重範, 宮澤康一, 大嶋龍司, 渋谷聡, 城田祐子

    臨床神経学(Web)　57　(6)　356(J‐STAGE)　2017

    ISSN： 1882-0654

  34. 原発性アミロイドーシスの1例

    斉藤 有佳, 菅野 重範, 宮澤 康一, 渋谷 聡, 下田 楓美子, 井泉 瑠美子, 鈴木 直輝, 堅山 真規

    臨床神経学　56　(11)　810-810　2016/11

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  35. 脳動脈瘤クリッピング術後に発症した脳膿瘍の一例

    下田楓美子, 安藤大祐, 菅野重範, 渋谷聡

    臨床神経学(Web)　56　(8)　584(J‐STAGE)　2016

    DOI： 10.5692/clinicalneurol.56_8_proceedings1 　

    ISSN： 1882-0654

  36. 重症筋無力症における血中抗GAD抗体価の検討

    安藤大祐, 鈴木靖士, 菅野重範, 渡辺源也, 三浦永美子, 田野大人, 突田健一, 青木正志

    日本神経学会学術大会プログラム・抄録集　57th　578　2016

  37. 原発性アミロイドーシスの1例

    斉藤有佳, 菅野重範, 宮澤康一, 渋谷聡, 下田楓美子, 井泉瑠美子, 鈴木直輝, 堅山真規

    臨床神経学(Web)　56　(11)　810(J‐STAGE)　2016

    ISSN： 1882-0654

  38. 脳梗塞とほぼ同時発症した痙攣発作(onset seizure)の1例

    松原史歩, 菅野重範, 宮澤康一, 望月廣, 渋谷聡

    臨床神経学(Web)　56　(11)　806(J‐STAGE)　2016

    ISSN： 1882-0654

  39. てんかん発作中による純粋語聾の1例

    四條 友望, 菅野 重範, 澁谷 聡, 及川 崇紀, 大沼 歩, 望月 廣

    臨床神経学　55　(7)　506-506　2015/07

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  40. 3次元脳血管撮影にてPercheron動脈を同定し得た脳底動脈先端症候群の1例

    渡辺靖章, 菅野重範, 宮澤康一, 望月廣, 澁谷聡

    臨床神経学(Web)　55　(12)　953(J‐STAGE)　2015

    ISSN： 1882-0654

  41. 歩行失行の1例

    福井健人, 中原岩平, 菅野重範, 望月廣, 澁谷聡

    臨床神経学(Web)　55　(12)　952(J‐STAGE)　2015

    ISSN： 1882-0654

  42. リステリア髄膜炎の2例

    菅原歩, 鈴木郁, 菅野重範, 及川崇紀

    臨床神経学(Web)　55　(1)　59(J‐STAGE)　2015

    ISSN： 1882-0654

  43. 特発性正常圧水頭症における脳内アミロイド沈着とシャント術による治療反応性の関連

    平岡宏太良, 成田渉, 菊池大一, 馬場徹, 菅野重範, 飯塚統, 田代学, 岡村信行, 古川敏勝, 荒井啓行, 岩田錬, 森悦朗, 谷内一彦

    日本神経学会学術大会プログラム・抄録集　54　(Suppl.)　S84-S84　2014/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  44. ステロイド反応性の再発性多発神経障害をきたし,馬尾生検で確診にいたったDLBCLの1例

    江面道典, 西山修平, 遠藤俊毅, 菅野重範, 小野紘彦, 向井由幸, 竪山真規, 黒田宙, 青木正志

    末梢神経　25　(2)　336　2014/12/01

    ISSN： 0917-6772

  45. Guillain‐Barre症候群様の症状を呈した悪性リンパ腫の1例

    湯川友貴, 菅野重範, 及川崇紀, 渋谷聡, 望月廣

    臨床神経学　54　(11)　925　2014/11/01

    ISSN： 0009-918X

  46. リウマチ性脳軟膜炎の脳生検例

    林昌伸, 及川崇紀, 菅野重範, 渋谷聡, 望月廣, 大友智, 荒井啓晶, 大藤高志

    臨床神経学　54　(11)　928　2014/11/01

    ISSN： 0009-918X

  47. ステロイド反応性の再発性多発神経障害をきたし,馬尾生検で確診にいたったDLBCLの1例

    江面道典, 西山修平, 遠藤俊毅, 菅野重範, 小野紘彦, 向井由幸, 黒田宙, 竪山真規, 青木正志

    日本末梢神経学会学術集会プログラム・抄録　25th　88　2014/07/31

  48. 特異な画像を呈した転移性脳腫瘍の1例

    澁谷聡, 遠藤彰, 菅野重範, 望月廣, 佐藤輝幸, 大藤高志, 松田真樹子

    臨床神経学　54　(3)　245　2014/03/01

    ISSN： 0009-918X

  49. アミロイドイメージングを用いたアルツハイマー病発症リスク予測法の実用化に関する多施設臨床研究 特発性正常圧水頭症における脳内アミロイド沈着とシャント術による治療反応性の関連

    田代学, 平岡宏太良, 成田渉, 菊池大一, 馬場徹, 菅野重範, 飯塚統, 岡村信行, 古川勝敏, 荒井啓行, 岩田錬, 森悦朗, 谷内一彦

    アミロイドイメージングを用いたアルツハイマー病発症リスク予測法の実用化に関する多施設臨床研究 平成23-25年度 総合研究報告書 平成25年度 総括・分担研究報告書　66-69　2014

  50. 特発性正常圧水頭症における反応抑制能力の障害に関連する大脳白質の障害部位

    菅野重範, 森悦朗

    日本神経学会学術大会プログラム・抄録集　55th　560　2014

  51. パーキンソン病合併が疑われる特発性正常圧水頭症の臨床・画像的特徴についての研究

    馬場徹, 小田桐逸人, 岩崎真樹, 金田朋洋, 菅野重範, 飯塚統, 松田実, 森悦朗

    日本神経学会学術大会プログラム・抄録集　55th　(Suppl.)　560-S83　2014

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  52. iNPHにおける脳内アミロイド沈着とシャント術による治療反応性の関連

    平岡宏太良, 成田渉, 菊池大一, 馬場徹, 菅野重範, 飯塚統, 田代学, 岡村信行, 古川勝敏, 荒井啓行, 岩田錬, 森悦朗, 谷内一彦

    日本正常圧水頭症学会プログラム・抄録集　15th　48　2014

  53. パーキンソン病合併が疑われる特発性正常圧水頭症の臨床・画像的特徴についての研究

    馬場徹, 小田桐逸人, 岩崎真樹, 金田朋洋, 菅野重範, 飯塚統, 松田実, 森悦朗

    日本正常圧水頭症学会プログラム・抄録集　15th　32　2014

  54. 再発した眼窩筋炎に小腸粘膜下腫瘍を合併した1例

    仲丸友望, 菅野重範, 小川諒, 及川祟紀, 渋谷聡, 望月廣

    臨床神経学　53　(9)　753　2013/09/01

    ISSN： 0009-918X

  55. アザチオプリン内服によりPosterior Reversible Encephalopathy Syndromeを発症した例

    小川諒, 及川崇紀, 仲丸友望, 菅野重範, 渋谷聡, 望月廣

    臨床神経学　53　(9)　757　2013/09/01

    ISSN： 0009-918X

  56. A need for assessment of balance in patients with idiopathic normal pressure hydrocephalus

    Kasumi Kanno, Yusuke Sekiguchi, Osamu Iizuka, Kentaro Baba, Shigenori Kanno, Etsuro Mori

    Hydrocephalus 2013 abstract book　2013/06

  57. Thickened membranous structure in the prepontine cistern is an underdiagnosed cause of normal pressure hydrocephalus

    Toru Baba, Shigenori Kanno, Osamu Iizuka, Masaki Iwasaki, Etsuro Mori

    Hydrocephalus 2013 abstract book　2013/06

  58. 脳血流シンチグラフィーで特徴的な経過が得られた舞踏運動を呈した1例

    小川諒, 及川崇紀, 仲丸友望, 菅野重範, 渋谷聡, 望月廣

    臨床神経学　53　(3)　260　2013/03/01

    DOI： 10.5692/clinicalneurol.53.260 　

    ISSN： 0009-918X

  59. 橋前槽のくも膜肥厚に伴う正常圧水頭症の臨床・画像的特徴について

    馬場徹, 菅野重範, 飯塚統, 岩崎真樹, 森悦朗

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集　7th　93　2013

  60. 特発性正常圧水頭症におけるシャント術後の脳白質変化:拡散テンソル画像を用いた検討

    菅野重範, 森悦朗

    日本神経学会学術大会プログラム・抄録集　54th　488　2013

  61. 特発性正常圧水頭症患者における脳内アミロイド沈着の検出

    平岡 宏太良, 菅野 重範, 菊池 大一, 田代 学, 岡村 信行, 古川 勝敏, 荒井 啓行, 岩田 錬, 森 悦朗, 谷内 一彦

    臨床神経学　52　(12)　1579-1579　2012/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  62. レビー小体型認知症の色恒常性の障害

    井上香, 平山和美, 下村辰雄, 西尾慶之, 井関一海, 飯塚統, 菅野重範, 森悦朗

    日本高次脳機能障害学会学術総会プログラム・講演抄録　36th　292　2012/10/17

  63. 心肺停止後に意識障害が遷延した特発正常圧水頭症の1例

    大友一樹, 戸枝美保, 菅野重範, 澁谷聡, 大友智, 塩入裕樹

    日本高次脳機能障害学会学術総会プログラム・講演抄録　36th　236　2012/10/17

  64. 大脳皮質基底核変性症(CBD)一例の左手の行為に関する検討:どうしても右手を手伝ってしまう

    太田祥子, 菅野重範, 遠藤佳子, 西尾慶之, 五味幸寛, 森悦朗

    日本高次脳機能障害学会学術総会プログラム・講演抄録　36th　207　2012/10/17

  65. 特発性正常圧水頭症患者における脳内アミロイド沈着の検出

    平岡宏太良, 菅野重範, 菊池大一, 田代学, 岡村信行, 古川勝敏, 荒井啓行, 岩田錬, 森悦朗, 谷内一彦

    核医学　49　(3)　251　2012/08/31

    ISSN： 0022-7854

  66. 特発性正常圧水頭症患者における脳内アミロイド沈着の検出

    平岡宏太良, 菅野重範, 菊池大一, 田代学, 岡村信行, 古川勝敏, 荒井啓行, 岩田錬, 森悦朗, 谷内一彦

    日本神経学会学術大会プログラム・抄録集　49　(3)　S231-S231　2012/08

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  67. てんかん発作中に純粋語聾を呈した一例

    仲丸友望, 澁谷聡, 及川祟紀, 望月廣, 菅野重範

    臨床神経学　52　(7)　524　2012/07/01

    ISSN： 0009-918X

  68. 顕著な視空間機能障害を呈した特発性正常圧水頭症の1例

    菊池大一, 菅野重範, 遠藤佳子, 飯塚統, 西尾慶之, 高木正仁, 齋藤真, 藤井俊勝, 森悦朗

    臨床神経学　52　(2)　123　2012/02/01

    ISSN： 0009-918X

  69. パーキンソン病におけるProgressive micrographiaの病態機序

    菅野重範, 篠原真弓, 菅野香純, 五味幸寛, 内山信, 西尾慶之, 馬場徹, 武田篤, 福田寛, 森悦朗

    日本神経学会学術大会プログラム・抄録集　53rd　230　2012

  70. Addenbrooke’s Cognitive Examination‐Revised(ACE‐R)日本語版の作成とその妥当性

    河田サントスケルシ人美, 橋本竜作, 西尾慶之, 小川七世, 菅野重範, 平岡宏太良, 横井香代子, 飯塚統, 森悦朗

    日本高次脳機能障害学会学術総会プログラム・講演抄録　35th　296　2011/10/01

  71. 進行性流暢性失語―LPAとSD―の神経心理学的および神経画像的比較

    小川七世, 西尾慶之, 小野内健司, 鈴木由希子, 木村史子, 飯塚統, 菅野重範, 田中佳子, 菊池大一, 森悦朗

    日本高次脳機能障害学会学術総会プログラム・講演抄録　35th　158　2011/10/01

  72. パーキンソン病患者におけるMicrographiaの病態機序

    菅野香純, 菅野重範, 篠原真弓, 五味幸寛, 内山信, 武田篤, 森悦朗

    日本高次脳機能障害学会学術総会プログラム・講演抄録　35th　222　2011/10/01

  73. 高低アクセントの表出異常を主症状とするForeign Accent Syndromeの1例

    佐々木浩児, 木村友紀, 松村愛子, 佐藤睦子, 菅野重範, 西尾慶之

    日本高次脳機能障害学会学術総会プログラム・講演抄録　35th　186　2011/10/01

  74. 右側頭後頭葉損傷により相貌失認,地誌的見当識障害を呈した一例

    工藤正子, 工藤正子, 工藤正子, 染谷浩美, 高橋賢子, 大部修治, 澁谷聡, 菅野重範

    日本高次脳機能障害学会学術総会プログラム・講演抄録　35th　210　2011/10/01

  75. Addenbrooke’s Cognitive Examination‐Revised(ACE‐R)日本語版の言語関連項目の有用性

    河田サントスケルシ人美, 橋本竜作, 西尾慶之, 小川七世, 菅野重範, 平岡宏太良, 横井香代子, 飯塚統, 森悦朗

    日本言語聴覚士協会総会・日本言語聴覚学会プログラム・抄録集　12th　204　2011/05/20

  76. 進行性流暢性失語の臨床症状―LPAとSDの比較検討―

    小川七世, 西尾慶之, 小野内健司, 鈴木由希子, 木村史子, 飯塚統, 菅野重範, 田中佳子, 菊池大一, 森悦朗

    日本言語聴覚士協会総会・日本言語聴覚学会プログラム・抄録集　12th　202　2011/05/20

  77. てんかん発症が先行した抗GAO抗体陽性小脳失調症の2例

    三浦永美子, 神一敬, 菅野重範, 長谷川隆文, 竪山真規, 武田篤

    日本神経学会学術大会プログラム・抄録集　52nd　351　2011

  78. 特発性正常圧水頭症における大脳白質障害 拡散テンソル画像による解析

    菅野 重範, 阿部 修士, 齋藤 真, 高木 正仁, 西尾 慶之, 菊池 大一, 平岡 宏太良, 飯塚 統, 森 悦朗

    臨床神経学　50　(12)　1108-1108　2010/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  79. シャント術による特発性正常圧水頭症の脳および脳脊髄液領域の体積変化の測定

    平岡 宏太良, 山崎 浩, 高木 正仁, 齋藤 真, 西尾 慶之, 飯塚 統, 菅野 重範, 菊池 大一, 森 悦朗

    臨床神経学　50　(12)　1157-1157　2010/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  80. 触覚性失認の一例

    遠藤佳子, 藤本ちあき, 菅野重範, 橋本竜作, 隈部俊宏, 森悦朗

    日本神経心理学会総会プログラム・予稿集　34th　120　2010/08/04

  81. 両側後頭葉損傷により,背側型同時失認を呈した1症例

    菅原由恵, 八巻賢子, 染谷浩美, 及川崇紀, 菅野重範, 平山和美

    日本神経心理学会総会プログラム・予稿集　34th　137　2010/08/04

  82. 特発性正常圧水頭症における大脳白質障害―拡散テンソル画像による解析―

    菅野重範, 阿部修士, 齋藤真, 高木正仁, 西尾慶之, 菊池大一, 平岡宏太良, 飯塚統, 森悦朗

    日本神経学会総会プログラム・抄録集　51st　205　2010

  83. パーキンソン病患者と健常高齢者の系列運動学習と再生における言語的手がかりの効果

    田渕香純, 菅野重範, 橋本竜作, 西尾慶之, 森悦朗

    理学療法学　37　ROMBUNNO.P1-023-A4P1023　2010

    Publisher: 公益社団法人 日本理学療法士協会

    DOI： 10.14900/cjpt.2009.0.A4P1023.0 　

    ISSN： 0289-3770

  84. シャント術による特発性正常圧水頭症の脳および脳脊髄液領域の体積変化の測定

    平岡宏太良, 山崎浩, 高木正仁, 齋藤真, 西尾慶之, 飯塚統, 菅野重範, 菊池大一, 森悦朗

    日本神経学会総会プログラム・抄録集　51st　256　2010

  85. 特発性正常圧水頭症(iNPH)における注意・遂行機能障害

    菅野 重範, 齋藤 真, 林 亜希子, 内山 信, 花木 りさ, 西尾 慶之, 山崎 浩, 平岡 宏太良, 高木 正仁, 菊池 大一, 森 悦朗, 久永 欣哉

    臨床神経学　49　(12)　1159-1159　2009/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  86. Logopenic/phonological variant of primarypr progressive aphasia(LPA)の1例

    小川七世, 西尾慶之, 高木正仁, 飯塚統, 菅野重範, 橋本竜作, 森悦朗

    日本神経心理学会総会プログラム・予稿集　33rd　64　2009/08/19

  87. 特発性正常圧水頭症(iNPH)における注意・遂行機能障害

    菅野重範, 齋藤真, 林亜希子, 内山信, 花木りさ, 西尾慶之, 山崎浩, 平岡宏太良, 高木正仁, 菊池大一, 森悦朗, 久永欣哉

    日本神経学会総会プログラム・抄録集　50th　323　2009

  88. 特発性正常圧水頭症のtap testによる認知機能の変化

    齋藤真, 西尾慶之, 飯塚統, 小倉加恵子, 平岡宏太良, 菅野重範, 平山和美, 鈴木匡子, 森悦朗

    神経心理学　22　(4)　305　2006/12/25

    ISSN： 0911-1085

  89. 肺腫瘍に対する放射線療法が神経症状進行抑制に有効だった抗Hu抗体陽性傍腫瘍性神経症候群の1例

    松本有史, 菅野重範, 菊池昭夫, 小野寺淳一, 久永欣哉, 木村格, 高野里奈, 高樹孝昌, 神一敬

    臨床神経学　46　(10)　738-738　2006/10/01

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  90. Delayed postanoxic encephalopathyの1例

    菅野重範, 鈴木匡子, 森悦朗, 中村靖, 桧野正俊

    臨床神経学　46　(10)　736　2006/10/01

    ISSN： 0009-918X

  91. 左前頭葉梗塞後にhyperlexiaを呈した1例

    深津玲子, 菅野重範, 上野彩, 佐々木結花

    日本神経心理学会総会プログラム・予稿集　30th　143　2006/08/05

  92. 特発性正常圧水頭症のtap testによる認知機能の変化

    齋藤真, 西尾慶之, 飯塚統, 小倉加恵子, 平岡宏太良, 菅野重範, 平山和美, 鈴木匡子, 森悦朗

    日本神経心理学会総会プログラム・予稿集　30th　78　2006/08/05

  93. Heubner arteryの梗塞により喚語困難を呈した1例

    渋谷聡, 菅野重範, 深津玲子, 松本有史, 久永欣哉, 木村格

    臨床神経学　46　(5)　362　2006/05/01

    ISSN： 0009-918X

  94. Comprehensive studies of neurologic diseases based on the policy medical treatment network. Discussion on classification of neurodegenerative disease with cognition disorder based on autopsy. Positioning of diffusive dementia with Lewy bodies and primary

    久永欣哉, 鈴木博義, 飛田宗重, 日沼雄二, 神一敬, 今野秀彦, 菅野重範, 深津玲子, 木村格

    政策医療ネットワークを基盤にした神経疾患の総合的研究 平成15-17年度 総括研究報告書　39-41　2006

  95. パーキンソン病のきゅう覚低下:fMRIによる検討

    武田篤, 斎藤尚宏, 菅野重範, 長谷川隆文, 菅野直人, 泉山昌洋, 糸山泰人

    日本神経学会総会プログラム・抄録集　47th　239　2006

  96. 多系統神経変性疾患としての原発性側索硬化症

    久永欣哉, 鈴木博義, 飛田宗重, 日沼雄二, 神一敬, 金原禎子, 菅野重範, 木村格

    日本神経学会総会プログラム・抄録集　47th　143　2006

  97. 見えるけれどわからない―連合型視覚性失認の一例―

    目黒祐子, 遠藤実, 平山和美, 菅野重範, 境信哉

    日本神経心理学会総会プログラム・予稿集　29th　134　2005/08/05

  98. Crossed cerebello‐cerebral diaschisisを認めた抗GAD抗体関連症候群の1例

    菅野重範, 長谷川隆文, 竪山真規, 志賀裕正, 糸山泰人, 鈴木匡子, 森悦郎

    臨床神経学　45　(6)　468　2005/06/01

    ISSN： 0009-918X

  99. コドン232に点変異(M232R)を持つ家族性CJDの臨床像

    菅野重範, 志賀裕正, 佐藤滋, 糸山泰人

    日本神経学会総会プログラム・抄録集　46th　204　2005

  100. 比較的長期経過を辿ったcodon232に点変異を有する家族性CJDの1例

    菅野重範, 長谷川隆文, 三好輝, 竪山真規, 志賀裕正, 糸山泰人, 北本哲之

    臨床神経学　45　(1)　70　2005/01/01

    ISSN： 0009-918X

  101. 病変部位によって異なったが画像所見,病理所見を呈した皮膚筋炎の1例

    中村正史, 菅野重範, 渡辺誠, 遠藤実, 藤井博司, 高沢徳彦, 村上一宏

    臨床神経学　44　(7)　479-479　2004/07/01

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  102. Reversible posterior leukoencephalopathy syndrome 4症例の臨床的検討

    渡辺誠, 菅野重範, 中村正史, 藤井博司, 小林正臣, 大沼歩, 遠藤実

    臨床神経学　44　(7)　483-483　2004/07/01

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  103. 左内頚動脈閉塞により失構音と意味理解を伴わない補完現象を呈した重度失語例

    目黒祐子, 細川恵子, 八鍬央子, 菅野重範

    高次脳機能研究　24　(1)　83-84　2004/03/31

    ISSN： 1348-4818

  104. 右前頭葉白質部に空洞を形成した多発性硬化症の1剖検例

    中村正史, 菅野重範, 渡辺誠, 遠藤実, 村上一宏, 今野秀彦

    臨床神経学　44　(1)　69-69　2004/01/01

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  105. 前交通動脈りゅう破裂によるSAH患者における言語・非言語の再認成績と頻度判断について

    目黒祐子, 菅野重範, 藤井俊勝

    神経心理学　19　(4)　231　2003/12/25

    ISSN： 0911-1085

  106. 左内頚動脈閉塞により失構音と意味理解を伴わない補完現象を呈した重度失語例

    目黒祐子, 細川恵子, 八鍬央子, 菅野重範

    日本高次脳機能障害学会総会プログラム・講演抄録　27th　136　2003/11/01

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Books and Other Publications 2

  1. 脳神経内科診療の掟

    岩田, 淳, 小林, 俊輔

    中外医学社　2024/06

    ISBN: 9784498428126

  2. 高次脳機能障害の理解と診察

    平山和美, 菅原由恵, 菅野重範

    Clinical Neuroscience　2013/04

Presentations 26

  1. 脳卒中セッション1 脳卒中の神経心理学 Invited

    菅野重範

    日本神経学会 第9回特別教育研修会　2025/08/10

  2. Distal ventriculoperitoneal shunt catheter migration into the hernia sac: A case report of idiopathic normal pressure hydrocephalus

    Shigenori Kanno

    The 26th Annual Meeting of the Japanese Society of NPH　2025/02/08

  3. The customized tissue probability map and gray and white matter templates can improve the accuracy of brain segmentation in patients with idiopathic normal pressure hydrocephalus

    Shigenori Kanno

    Hydrocephalus2024　2024/09/14

  4. アルツハイマー病の併存が疑われる特発性正常圧水頭症患者の症候学的特徴に関する検討

    菅野重範

    第25回日本正常圧水頭症学会学術集会　2024/02/17

  5. 特発性正常圧水頭症患者における脳解剖画像の分離と標準化の精度向上を目的とした研究

    菅野重範

    第43回日本認知症学会学術集会　2024/11/22

  6. 時間が経過したという感じ Invited

    菅野重範

    第47回日本高次脳機能障害学会学術総会　2023/10/28

  7. 聴覚路の損傷による聞こえ方の変化 -自験例の紹介- Invited

    菅野重範

    第46回日本高次脳機能障害学会学術総会　2022/12/03

  8. 良性発作性頭位めまい症様の反復性めまい発作が 髄液シャント術後に出現しなくなった特発性正常圧水頭症の 1 例

    菅野重範

    第23回日本正常圧水頭症学会　2022/06/18

  9. 認知症の診療に欠かせない神経心理学 Invited

    菅野重範

    第19回専門医育成教育セミナー （第63回日本神経学会学術大会）　2022/05/18

  10. 特発性正常圧水頭症における症候と脳白質障害,Default mode networkの障害との関連性

    菅野重範

    第61回日本神経学会学術大会

  11. iNPH診療におけるリハビリテーションの役割と今後の課題 Invited

    菅野重範

    第21回日本正常圧水頭症学会プレミーティングセミナー

  12. 特発性正常圧水頭症の重症度に関連した安静時脳内ネットワークに関する検証

    菅野 重範

    第60回日本神経学会学術大会　2019/05/24

  13. 特発性正常圧水頭症における持続性注意と反応抑制の障害

    菅野 重範

    第20回日本正常圧水頭症学会　2019/02/23

  14. Preoperative evaluation of thalamic volume predicts shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

    Kanno Shigenori

    2018/05/26

  15. L-DOPAの投与中止によりカタトニアが改善したパーキンソン病の1例

    菅野 重範

    第100回日本神経学会東北地方会　2017/09/30

  16. Preoperative evaluation of thalamic volume might predict shunt responsiveness in patients with idiopathic normal pressure hydrocephalus International-presentation

    Hydrocephalus 2017　2017/09/24

  17. A change in brain white matter after shunt surgery in idiopathic normal pressure hydrocephalus International-presentation

    Kanno Shigenori

    XXIII World Congress of Neurology　2017/09/19

  18. The cerebral white matter lesions associated with a deficit in response suppression in idiopathic normal pressure hydrocephalus International-presentation

    Kanno Shigenori

    Hydrocephalus 2013　2013/06/29

  19. A change in the brain white matter involvement after shunt surgery in idiopathic normal pressure hydrocephalus: a diffusion tensor imaging study

    Kanno Shigenori

    2013/06/01

  20. パーキンソン病における Progressive micrographiaの病態機序

    菅野 重範

    第53回日本神経学会学術大会　2012/05/23

  21. 特発性正常圧水頭症（iNPH）における 大脳白質障害のシャント術による変化 －拡散テンソル画像（DTI）を用いた検討－

    菅野 重範

    第13回日本水頭症学会　2012/02/11

  22. 断酒を契機にせん妄を発症した1例

    菅野 重範

    第15回日本神経精神医学会　2010/12/04

  23. White matter involvement in idiopathic normal pressure hydrocephalus: a voxel-based diffusion tensor imaging study

    Shigenori Kanno

    14th EFNS Congress　2010/09/26

  24. 特発性正常圧水頭症における 注意・遂行機能障害の評価 - Count-backward testの有用性 -

    菅野 重範

    第11回日本正常圧水頭症研究会　2010/02/06

  25. The utility of the count-backward test in evaluating attentional/executive dysfunction in idiopathic normal pressure hydrocephalus International-presentation

    Kanno Shigenori

    Hydrocephalus 2009　2009/09/19

  26. Familial Creutzfeldt-Jakob disease with a point mutation of methionine to arginine at codon 232 of prion protein gene: Two different phenotypes

    Shigenori Kanno

    57th Annual Meeting of the American Academy of Neurology (AAN)　2005/04/12

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Research Projects 6

  1. Pathological analysis of idiopathic normal-pressure hydrocephalus using neuroinflammation PET imaging

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2024/04/01 - 2028/03/31

  2. 構音の異常に関する客観的指標の開発と病態機序の解明

    菅野 重範

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2024/04/01 - 2028/03/31

  3. The study of developing the standard brain templates for idiopathic normal pressure hydrocephalus (iNPH) and diagnosing Alzheimer's disease (AD) comorbid with iNPH

    Offer Organization: Nihon Medi-Physics Co., Ltd.

    Institution: Tohoku University

    2023/08 - 2026/03

  4. Multidisciplinary study on the neural bases of the Japanese language based on the damaged brain - from individual differences to tailored medicine.

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2025/03/31

  5. 特発性正常圧水頭症の認知・精神・行動障害に関連する神経基盤の解明

    菅野 重範, 三須 建郎

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2020/04 - 2025/03

    More details Close

    2021年度は，東北大学病院高次脳機能障害科に入院された特発性正常圧水頭症患者のうち10名から本研究の参加同意を得た．注意機能，遂行機能，記憶能力を中心に評価する神経心理検査，歩行検査，安静時機能的MRIの撮像，拡散テンソル画像の撮像，脳血流シンチと線条体シンチの撮像，アルツハイマー病に関連する髄液バイオマーカーの測定が全例において施行された．また，研究代表者が作成した特発性正常圧水頭症の3主徴（歩行障害，認知機能障害，排尿障害）の重症度を評価するアンケートが患者とその介護者の全例におてい施行され、3主徴に関する病態失認の重症度を全例で評価することができた。その一方、無為・無関心の評価に関しては、新型コロナウィルス感染の流行により、多くの研究参加者が日常生活での行動の制限を受けてしまったため、評価の継続を断念せざるを得なかった。 昨年度の研究参加者を含めた安静時機能的MRI画像のデータを用いて、独立成分分析を施行した結果、研究代表者の先行研究において特発性正常圧水頭症における認知機能 （特に注意機能と記憶能力）との強い関連が示されたDefault mode networkと，内受容性の情報に基づいてどの内的・外的情報に最も関心を向けるのかを制御しているとされているSalience network，意図した行為の実行に深く関連するものと推察される左右各々のexecutive networkを、昨年度と同様に全て検出することができた．また，拡散テンソル画像のデータを解析することにより，各患者における大脳白質の構造完全性を測定することもできた．2022年度も2020年度、2021年度と同様に，特発性正常圧水頭症患者から研究参加者を募り，上記のデータの収集を継続する予定である．

  6. 特発性正常圧水頭症における遂行機能障害－新しい検査法の開発と病態機序の解明－ Competitive

    菅野 重範

    Offer Organization: 文部科学省

    System: 科学研究費助成事業

    2016/04 - 2019/03

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Teaching Experience 2

  1. 基礎ゼミ　東北大学

  2. 臨床医学 神経ブロック　東北大学

Social Activities 7

  1. 早期アルツハイマー病における診断のポイント

    石巻市医師会学術講演会

    2024/12/03 - 2024/12/03

  2. 「特発性正常圧水頭症に気づくポイント」 〜改善が期待できる認知症〜

    2019/08/28 - 2019/08/28

  3. 第11回元気！健康！フェア in とうほく

    2019/04/06 - 2019/04/07

  4. 仙南医療圏における認知症の診療 ～みやぎ県南中核病院での経験から～

    2018/11/15 - 2018/11/15

  5. 認知症性疾患の鑑別診断 アルツハイマー病、レビー小体型認知症、特発性正常圧水頭症を中心に

    2014/03/13 - 2014/03/13

  6. 成人の水頭症 －鑑別診断と治療－

    2012/11/26 - 2012/11/26

  7. 認知症性疾患の鑑別疾患と治療 アルツハイマー病、レビー小体型認知症、特発性正常圧水頭症を中心に

    2012/09/11 - 2012/09/11

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