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Miho Shidahara

Section

Graduate School of Engineering

Job title

Associate Professor

Degree

博士（工学）（東北大学）
修士（工学）（東北大学）

researchmap

https://researchmap.jp/7000014648

J-GLOBAL ID

201601008908656100

Research History 8

2022/10 - Present

Tohoku University　Graduate School of Engineering
2018/04 - 2022/09

Tohoku University
2010/04 - 2018/03

Tohoku University
2006/01 - 2010/03

放射線医学総合研究所　研究員
2003/01 - 2005/12

日本学術振興会　特別研究員PD
2002/04 - 2002/12

国立長寿医療研究センター研究所　流動研究員
2000/01 - 2001/08

国立循環器病センター研究所　放射線医学研究部　研修生
1999/02 - 2000/01

秋田県立脳血流血管研究所　放射線医学部　研修生

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Education 2

Tohoku University

1997/04 - 2002/03
Tohoku University　Faculty of Engineering

1993/04 - 1997/03

Committee Memberships 16

仙台市　廃棄物対策審議会委員

2024/10 - Present
公益社団法人日本アイソトープ協会　第4期理工・ライフサイエンス部会常任委員

2024/04 - Present
日本核医学会　ダイバーシティ・エクイティ＆インクルージョン委員会委員

2023/11 - Present
日本学術会議　連携会員

2023/10 - Present
日本核医学会北日本地方会　世話人

2023/07 - Present
公益社団法人日本アイソトープ協会　RADIOISOTOPES誌編集委員

2023/04 - Present
Frontiers in Nuclear Medicine　Associate Editor

2023/03 - Present
日本原子力学会東北支部　幹事

2018/05 - Present
日本核医学会　核医学理工分科会世話人

2016/12 - Present
IEEE Sendai Women in Engineering　Chair

2023/01 - 2024/12
日本放射線技術学会　Radiological Physics and Technology Guest Associate editor

2015/04 - 2023/12
日本核医学会　ダイバーシティー推進準備委員会委員

2022/03 - 2023/10
IEEE Sendai Women in Engineering　Secretary and Treasurer

2021/01 - 2022/12
日本核医学会　Annals of Nuclear Medicine 編集委員

2017/10 - 2021/10
日本核医学会　PET短寿命核種の規制にかかる小委員会委員

2015/12 - 2018/03
日本核医学会　WG核医学用ディジタルファントムの作成メンバー

2005/04 - 2007/03

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Professional Memberships 4

日本核医学会(1997/10-)
日本脳神経核医学研究会(2012/10-)
ISCBFM(2009/03-)
IEEE(2005/10-)

Research Areas 1

Life sciences / Medical systems /

Awards 7

第63回日本核医学会賞

2024/11　日本核医学会
Senior Member

2021/12　IEEE
Frequently Cited Paper 2018

2019/07　Annals of Nuclear Medicine
第2回久田賞

2010/11/11　日本核医学会　Annals of Nuclear Medicine機関紙論文賞
第6回日本核医学会研究奨励賞

2009/10　日本核医学会
Finalist for the Niels Lassen Award 2009

2009/07　International Society for Cerebral Blood Flow
Young Investigator bursary Award

2008/06　Neuroreceptor Mapping 2008

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Papers 82

Recent Trends of Dosimetry in Radionuclide Therapy: Dosimetry Software Invited Peer-reviewed

Miho Shidahara

RADIOISOTOPES　74　(2)　in press　2025/06
DOCK–PET: database of CNS kinetic parameters in the healthy human brain for existing PET tracers

Itsuki Miyajima, Ayano Yoshikawa, Kyosei Sahashi, Chie Seki, Yuji Nagai, Hiroshi Watabe, Miho Shidahara

Annals of Nuclear Medicine　38　(8)　666-672　2024/05/30
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12149-024-01947-z 　

ISSN： 0914-7187

eISSN： 1864-6433
Preclinical Characterization of the Tau PET Tracer [¹⁸F]SNFT-1: Comparison of Tau PET Tracers Peer-reviewed

Ryuichi Harada, Pradith Lerdsirisuk, Yuki Shimizu, Yuka Yokoyama, Yiqing Du, Kaede Kudo, Michinori Ezura, Yoichi Ishikawa, Ren Iwata, Miho Shidahara, Aiko Ishiki, Akio Kikuchi, Yuya Hatano, Tomohiko Ishihara, Osamu Onodera, Yasushi Iwasaki, Mari Yoshida, Yasuyuki Taki, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai, Shozo Furumoto, Nobuyuki Okamura

Journal of Nuclear Medicine　jnumed.123.265593-jnumed.123.265593　2023/06/15
Publisher: Society of Nuclear Medicine
DOI： 10.2967/jnumed.123.265593 　

ISSN： 0161-5505

eISSN： 2159-662X
Brain partial volume correction with point spreading function reconstruction in high-resolution digital PET: comparison with an MR-based method in FDG imaging Peer-reviewed

Masanobu Ibaraki, Keisuke Matsubara, Yuki Shinohara, Miho Shidahara, Kaoru Sato, Hiroyuki Yamamoto, Toshifumi Kinoshita

Ann Nucl Med　36　(8)　717-727　2022/08

DOI： 10.1007/s12149-022-01753-5 　

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OBJECTIVE: In quantitative positron emission tomography (PET) of the brain, partial volume effect due mainly to the finite spatial resolution of the PET scanner (> 3 mm full width at half maximum [FWHM]) is a primary source of error in the measurement of tracer uptake, especially in small structures such as the cerebral cortex (typically < 3 mm thickness). The aim of this study was to evaluate the partial volume correction (PVC) performance of point spread function-incorporated reconstruction (PSF reconstruction) in combination with the latest digital PET scanner. This evaluation was performed through direct comparisons with magnetic resonance imaging (MR)-based PVC (used as a reference method) in a human brain study. METHODS: Ten healthy subjects underwent brain 18F-FDG PET (30-min acquisition) on a digital PET/CT system (Siemens Biograph Vision, 3.5-mm FWHM scanner resolution at the center of the field of view) and anatomical T1-weighted MR imaging for MR-based PVC. PSF reconstruction was applied with a wide range of iterations (4 to 256; 5 subsets). FDG uptake in the cerebral cortex was evaluated using the standardized uptake value ratio (SUVR) and compared between PSF reconstruction and MR-based PVC. RESULTS: Cortical structures were visualized by PSF reconstruction with several tens of iterations and were anatomically well matched with the MR-derived cortical segments. Higher numbers of iterations resulted in higher cortical SUVRs, which approached those of MR-based PVC (1.76), although even with the maximum number of iterations they were still smaller by 16% (1.47), corresponding to approximately 1.5-mm FWHM of the effective spatial resolution. CONCLUSION: With the latest digital PET scanner, PSF reconstruction can be used as a PVC technique in brain PET, albeit with suboptimal resolution recovery. A relative advantage of PSF reconstruction is that it can be applied not only to cerebral cortical regions, but also to various small structures such as small brain nuclei that are hardly visualized on anatomical T1-weighted imaging, and thus hardly recovered by MR-based PVC.
Noninvasive estimation of human radiation dosimetry of 18F-FDG by whole-body small animal PET imaging in rats. International-journal Peer-reviewed

Miho Shidahara, Yoshihito Funaki, Hiroshi Watabe

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine　181　110071-110071　2022/03

DOI： 10.1016/j.apradiso.2021.110071 　

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PURPOSE: Small animal PET provides the biodistribution of administrated radiotracer in vivo and have a potential to contribute on dosimetry study. The aim of this study is to investigate the effect of region-of-interest (ROI)-delineation in whole-body rat PET image toward non-invasive estimation of human dosimetry of 18F-FDG. METHOD: After administration of 18F-FDG (averaged 11.7 MBq), 3.5-h PET and 20-min CT scans were sequentially performed for three rats by Clairvivo PET/CT system. Seven source organs, and the remainder of the body, were studied to extrapolate %ID(t) and estimate time-integrated activity coefficients [kBq-h/MBq] in human. The mean absorbed dose in each target organ and the effective dose were estimated by MIRD method. Effects of ROI-definitions on both extrapolated %ID(t) in human and estimated doses were also investigated by using (i) small ROIs of high uptake region and (ii) whole organ ROIs. RESULTS: Averaged effective doses of 18F-FDG in human by using high-uptake and whole-organ ROIs were 27.8 ± 6.54 and 19.3 ± 2.72 μSv/MBq, respectively. CONCLUSION: The use of small animal PET scanner, which allows repeatedly PET scans, have a potential to contribute on the reduction of the number of experimental animals. However, the ways of ROI drawing influences on the estimated effective dose and safe-side ROI definition may be preferred.
Iterative framework for image registration and partial volume correction in brain positron emission tomography.

Keisuke Matsubara, Masanobu Ibaraki, Miho Shidahara, Toshibumi Kinoshita

Radiological physics and technology　13　(4)　348-357　2020/12

DOI： 10.1007/s12194-020-00591-2 　

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Imprecise registration between positron emission tomography (PET) and anatomical magnetic resonance (MR) images is a critical source of error in MR imaging-guided partial volume correction (MR-PVC). Here, we propose a novel framework for image registration and partial volume correction, which we term PVC-optimized registration (PoR), to address imprecise registration. The PoR framework iterates PVC and registration between uncorrected PET and smoothed PV-corrected images to obtain precise registration. We applied PoR to the [11C]PiB PET data of 92 participants obtained from the Alzheimer's Disease Neuroimaging Initiative database and compared the registration results, PV-corrected standardized uptake value (SUV) and its ratio to the cerebellum (SUVR), and intra-region coefficient of variation (CoV) between PoR and conventional registration. Significant differences in registration of as much as 2.74 mm and 3.02° were observed between the two methods (effect size < - 0.8 or > 0.8), which resulted in considerable SUVR differences throughout the brain, reaching a maximal difference of 62.3% in the sensory motor cortex. Intra-region CoV was significantly reduced using the PoR throughout the brain. These results suggest that PoR reduces error as a result of imprecise registration in PVC and is a useful method for accurately quantifying the amyloid burden in PET.
Error propagation analysis of seven partial volume correction algorithms for [18F]THK-5351 brain PET imaging. International-journal Peer-reviewed

Senri Oyama, Ayumu Hosoi, Masanobu Ibaraki, Colm J McGinnity, Keisuke Matsubara, Shoichi Watanuki, Hiroshi Watabe, Manabu Tashiro, Miho Shidahara

EJNMMI physics　7　(1)　57-57　2020/09/14

DOI： 10.1186/s40658-020-00324-9 　

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BACKGROUND: Novel partial volume correction (PVC) algorithms have been validated by assuming ideal conditions of image processing; however, in real clinical PET studies, the input datasets include error sources which cause error propagation to the corrected outcome. METHODS: We aimed to evaluate error propagations of seven PVCs algorithms for brain PET imaging with [18F]THK-5351 and to discuss the reliability of those algorithms for clinical applications. In order to mimic brain PET imaging of [18F]THK-5351, pseudo-observed SUVR images for one healthy adult and one adult with Alzheimer's disease were simulated from individual PET and MR images. The partial volume effect of pseudo-observed PET images were corrected by using Müller-Gärtner (MG), the geometric transfer matrix (GTM), Labbé (LABBE), regional voxel-based (RBV), iterative Yang (IY), structural functional synergy for resolution recovery (SFS-RR), and modified SFS-RR algorithms with incorporation of error sources in the datasets for PVC processing. Assumed error sources were mismatched FWHM, inaccurate image-registration, and incorrectly segmented anatomical volume. The degree of error propagations in ROI values was evaluated by percent differences (%diff) of PV-corrected SUVR against true SUVR. RESULTS: Uncorrected SUVRs were underestimated against true SUVRs (- 15.7 and - 53.7% in hippocampus for HC and AD conditions), and application of each PVC algorithm reduced the %diff. Larger FWHM mismatch led to larger %diff of PVC-SUVRs against true SUVRs for all algorithms. Inaccurate image registration showed systematic propagation for most algorithms except for SFS-RR and modified SFS-RR. Incorrect segmentation of the anatomical volume only resulted in error propagations in limited local regions. CONCLUSIONS: We demonstrated error propagation by numerical simulation of THK-PET imaging. Error propagations of 7 PVC algorithms for brain PET imaging with [18F]THK-5351 were significant. Robust algorithms for clinical applications must be carefully selected according to the study design of clinical PET data.
18F-SMBT-1: A Selective and Reversible Positron-Emission Tomography Tracer for Monoamine Oxidase-B Imaging. International-journal Peer-reviewed

Ryuichi Harada, Yoshimi Hayakawa, Michinori Ezura, Pradith Lerdsirisuk, Yiqing Du, Yoichi Ishikawa, Ren Iwata, Miho Shidahara, Aiko Ishiki, Akio Kikuchi, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai, Shozo Furumoto, Nobuyuki Okamura

Journal of nuclear medicine : official publication, Society of Nuclear Medicine　62　(2)　253-258　2020/07/09

DOI： 10.2967/jnumed.120.244400 　

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Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (S)-(2-methylpyrid-5-yl)-6-[(3-[18F]fluoro-2-hydroxy)propoxy]quinoline, (18F-SMBT-1), was successfully developed via lead optimization from first-generation tau positron-emission tomography (PET) tracer 18F-THK-5351. Methods: SMBT-1 was radiolabeled with fluorine-18 using the corresponding precursor. The binding affinity of radiolabeled compounds to MAO-B was assessed using saturation and competitive binding assays. The binding selectivity of 18F-SMBT-1 to MAO-B was evaluated by autoradiography of frozen human brain tissues. The pharmacokinetics (PK) and metabolism were assessed in normal mice after intravenous administration of 18F-SMBT-1. A 14-day toxicity study following the intravenous administration of SMBT-1 was performed using rats and mice. Results: In vitro binding assays demonstrated a high binding affinity of SMBT-1 to MAO-B (KD = 3.7 nM). In contrast, it showed low binding affinity to MAO-A and protein aggregates such as amyloid-β and tau fibrils. Autoradiographic analysis showed higher amounts of 18F-SMBT-1 binding in the Alzheimer's disease (AD) brain sections than in the control brain sections. 18F-SMBT-1 binding was completely displaced with reversible MAO-B inhibitor lazabemide, demonstrating the high selectivity of 18F-SMBT-1 for MAO-B. Furthermore, 18F-SMBT-1 showed a high uptake by brain, rapid washout, and no radiolabeled metabolites in the brain of normal mice. SMBT-1 showed no significant binding to various receptors, ion channels, and transporters, and no toxic effects related to its administration were observed in mice and rats. Conclusion:18F-SMBT-1 is a promising and selective MAO-B PET tracer candidate, which would be useful for quantitative monitoring of astrogliosis in the human brain.
From the respective expert viewpoints of the ANM specialty editors

Masayuki Inubushi, Miho Shidahara, Yasuyuki Takahashi, Mikako Ogawa, Yasushi Kiyono

Annals of Nuclear Medicine　33　(12)　877-880　2019/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12149-019-01421-1 　

ISSN： 0914-7187

eISSN： 1864-6433

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<title>Abstract</title>Although it may not be well known, the Annals of Nuclear Medicine (ANM) Editorial Committee includes one specialty editor of nuclear medicine physics, one of nuclear medicine technology, one of molecular imaging, and two of radiopharmacology. In addition, a statistics editor and a language editor are also on the committee. Manuscripts submitted to ANM can be peer-reviewed by such specialty editors similar to those submitted to highly ranked journals, which is a great pride and joy to us. To offer our readers a condensed global view on the high-quality research work in the field of nuclear medicine, we have published a mini-review article every year under the joint authorship of the ANM associate editors since 2016. This is our fourth serial review article written by the ANM specialty editors from their respective expert viewpoints.
Altered Gender Difference in Brain Histamine H1 Receptor Binding in Patients with Irritable Bowel Syndrome: A Positron Emission Tomography Study Peer-reviewed

Morishita J, Shidahara M, Shoji T, Endo Y, Sato Y, Kano M, Kanazawa M, Tashiro M, Yanai K, Fukudo S

Gastroenterology　156　(6)　S-26-S-27　2019/05
Biomathematical Modeling Approach to Predict Clinical SUVRs for Amyloid PET Imaging

Shidahara M, Seki C, Nai YH, Okamura, Furumoto S, Yanai K, Watabe H, Tashiro M

CYRIC Annual Report 2016-2017　147-151　2019/04
Partial Volume Corrections for Tau and Amyloid PET Imaging with [18F]THK5351 and [11C]PiB

Shidahara M, Thomas AB, Okamura N, Ibaraki M, Matsubara K, Oyama S, Ishikawa Y, Watanuki S, Iwata R, Furumoto S, Yanai K, Watabe H, Tashiro M

CYRIC Annual Report 2016-2017　142-146　2019/04
A systematic performance evaluation of head motion correction techniques for 3 commercial PET scanners using a reproducible experimental acquisition protocol. Peer-reviewed

Inomata T, Watanuki S, Odagiri H, Nambu T, Karakatsanis NA, Ito H, Watabe H, Tashiro M, Shidahara M

Annals of nuclear medicine　33　(7)　459-470　2019/03
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12149-019-01353-w 　

ISSN： 0914-7187

eISSN： 1864-6433
Renal statistical map for positron emission tomography with [O-15] water. International-journal Peer-reviewed

Mahabubur Rahman, Hiroshi Watabe, Miho Shidahara, Shoichi Watanuki, Manabu Tashiro, Takefumi Mori, Sadayoshi Ito, Yusuke Ohsaki

American journal of nuclear medicine and molecular imaging　9　(4)　193-202　2019

ISSN： 2160-8407

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Image statistics are frequently used for functional and molecular imaging research in which images from a patient group with a specific diagnosis are compared with images from a healthy control group who have been matched for demographic variables. The success of image statistics for brain imaging has encouraged us to develop a method for obtaining volumetrically normalized kidney to perform image statistics so that we can locally visualize the statistical significant difference comparing voxel by voxel between certain groups in terms kidney blood flow kinetic parameters. For the development of this evolutionary process, we first volumetrically normalized all subjects, which include healthy control (HC) and chronic renal failure (CRF) patients, 15O water PET image with respect to one HC subject's MRI image using affine transformation. Then 15O kinetic parametric images of normalized kidneys were obtained through the basis function method. Finally, the statistical map of these parametric images was produced using the threshold-free cluster enhancement based permutation method. Kinetic parameters of kidney namely, uptake rate constant (K1), clearance rate constant (k2) and blood volume (Va), were found to be notably lower in CRF than those of in HC and k2 parameter was found to be more stable compared to K1 and Va. The statistical map of these parametric images allowed us to visualize local significant differences statistically (P<0.05) between HC and CRF groups. Though PET and MRI techniques have enormous potentiality for functional and molecular imaging of kidney, these are, at best, in experimental level. It is speculated that statistical mapping of kidney could play a significant role in the successful implementation of functional and molecular kidney imaging. However, more research involving a larger sample size and improved normalization technique will be needed for the robustness of the process.
頭部PET体動補正精度の装置間比較統一実験プロトコルを用いた検討

猪又嵩斗, 志田原美保, 四月朔日聖一, 小田桐逸人, 南部武幸, 伊藤浩, 田代学, 渡部浩司

核医学技術　38　(予稿集)　403-403　2018/10
Publisher: (NPO)日本核医学技術学会
ISSN： 0289-100X
Error propagation properties of 5 partial volume correction algorithms for [F-18]THK5351 PET imaging Peer-reviewed

Oyama S, Shidahara M, Thomas B. A, Matsubara K, Ibaraki M, Watanuki S, Watabe H, Tashiro M

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　45　S300　2018/10

ISSN： 1619-7070
Biomathematical screening of amyloid radiotracers with clinical usefulness index Peer-reviewed

Ying-Hwey Nai, Miho Shidahara, Chie Seki, Hiroshi Watabe

Alzheimer's and Dementia: Translational Research and Clinical Interventions　3　(4)　542-552　2017/11/01
Publisher: Elsevier Inc
DOI： 10.1016/j.trci.2017.08.006 　

ISSN： 2352-8737
ラットPETを用いたヒト内部被曝線量の非侵襲的推定手法の検討

志田原美保, 猪又嵩斗, 小山千莉, 船木善仁, 田代学, 古本祥三, 谷内一彦, 権田幸祐, 渡部浩司

核医学　54　(Suppl.)　S199-S199　2017/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
トレーサブル68Ge/68Ga点状線源を用いるPET装置の校正法

小山翔司, 長谷川智之, 井上優介, 菊池敬, 宮武比呂樹, 我妻慧, 宮司典明, 渡部浩司, 志田原美保, 四月朔日聖一, 津田啓介, 村松禎久, 柳澤かおり, 和田康弘, 織田圭一, 佐藤泰

核医学技術　37　(予稿集)　481-481　2017/09
Publisher: (NPO)日本核医学技術学会
ISSN： 0289-100X
137Cs transmission imaging and segmented attenuation corrections in a small animal PET scanner Peer-reviewed

Ying-Hwey Nai, Takayuki Ose, Miho Shidahara, Hiroshi Watabe

Radiological Physics and Technology　10　(3)　321-330　2017/09/01
Publisher: Springer Tokyo
DOI： 10.1007/s12194-017-0407-4 　

ISSN： 1865-0341 1865-0333
Prediction of the Clinical SUV Ratio in Amyloid PET Imaging Using a Biomathematic Modeling Approach Toward the Efficient Development of a Radioligand Peer-reviewed

Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe

JOURNAL OF NUCLEAR MEDICINE　58　(8)　1285-1292　2017/08

DOI： 10.2967/jnumed.116.183566 　

ISSN： 0161-5505

eISSN： 1535-5667
A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [F-18]THK5351 and [C-11]PIB Peer-reviewed

Miho Shidahara, Benjamin A. Thomas, Nobuyuki Okamura, Masanobu Ibaraki, Keisuke Matsubara, Senri Oyama, Yoichi Ishikawa, Shoichi Watanuki, Ren Iwata, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe

ANNALS OF NUCLEAR MEDICINE　31　(7)　563-569　2017/08

DOI： 10.1007/s12149-017-1185-0 　

ISSN： 0914-7187

eISSN： 1864-6433
Validation of a Novel Calibration Method Using a Traceable 68Ge/68Ga Point-Like Source On Eleven Types of PET Scanners Peer-reviewed

Koyama S, Hasegawa T, Miyatake H, Inoue Y, Kikuchi K, Wagatsuma K, Miyaji N, Watabe H, Shidahara M, Watanuki S, Tsuda K, Muramatsu Y, Yanagisawa K, Wada Y, Oda K, Sato Y, Yamada T

MEDICAL PHYSICS　44　(6)　2017/06

ISSN： 0094-2405
F-18-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease Peer-reviewed

Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Tetsuro Tago, Kotaro Hiraoka, Shoichi Watanuki, Miho Shidahara, Masayasu Miyake, Yoichi Ishikawa, Rin Matsuda, Akie Inami, Takeo Yoshikawa, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo

JOURNAL OF NUCLEAR MEDICINE　57　(2)　208-214　2016/02

DOI： 10.2967/jnumed.115.164848 　

ISSN： 0161-5505

eISSN： 1535-5667
Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards Peer-reviewed

K. Sato, M. Shidahara, H. Watabe, S. Watanuki, Y. Ishikawa, Y. Arakawa, Y. H. Nai, S. Furumoto, M. Tashiro, T. Shoji, K. Yanai, K. Gonda

PHYSICS IN MEDICINE AND BIOLOGY　61　(2)　696-711　2016/01

DOI： 10.1088/0031-9155/61/2/696 　

ISSN： 0031-9155

eISSN： 1361-6560
PET解析技術の開発

渡部浩司, 志田原美保

放射線　41　(4)　191-195　2016
Publisher:
ISSN： 0285-3604
Quantitative kinetic analysis of PET amyloid imaging agents [C-11]BF227 and [F-18]FACT in human brain Peer-reviewed

Miho Shidahara, Hiroshi Watabe, Manabu Tashiro, Nobuyuki Okamura, Shozo Furumoto, Shoichi Watanuki, Katsutoshi Furukawa, Yuma Arakawa, Yoshihito Funaki, Ren Iwata, Kohsuke Gonda, Yukitsuka Kudo, Hiroyuki Arai, Kiichi Ishiwata, Kazuhiko Yanai

NUCLEAR MEDICINE AND BIOLOGY　42　(9)　734-744　2015/09

DOI： 10.1016/j.nucmedbio.2015.05.001 　

ISSN： 0969-8051

eISSN： 1872-9614
Aliased noise in X-ray CT images and band-limiting processing as a preventive measure Peer-reviewed

Kazuhiro Sato, Miho Shidahara, Mitsunori Goto, Isao Yanagawa, Noriyasu Homma, Issei Mori

Radiological Physics and Technology　8　(2)　178-192　2015/07/23
Publisher: Springer-Verlag Tokyo
DOI： 10.1007/s12194-015-0306-5 　

ISSN： 1865-0341 1865-0333
[F-18]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease Peer-reviewed

Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, Miho Shidahara, Masayasu Miyake, Yoichi Ishikawa, Rin Matsuda, Akie Inami, Takeo Yoshikawa, Tetsuro Tago, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　42　(7)　1052-1061　2015/06

DOI： 10.1007/s00259-015-3035-4 　

ISSN： 1619-7070

eISSN： 1619-7089
Kinetic Models for PET/SPECT Imaging.

Miho Shidahara, Hiroshi Watabe, Iwao Kanno

Encyclopedia of Computational Neuroscience　2014
Publisher: Springer
DOI： 10.1007/978-1-4614-7320-6_526-1 　
Quantification of opioid receptor availability following spontaneous epileptic seizures: Correction of [11C]diprenorphine PET data for the partial-volume effect Peer-reviewed

Colm J. McGinnity, Miho Shidahara, Maria Feldmann, Shiva Keihaninejad, Daniela A. Riaño Barros, Ioannis S. Gousias, John S. Duncan, David J. Brooks, Rolf A. Heckemann, Federico E. Turkheimer, Alexander Hammers, Matthias J. Koepp

NeuroImage　79　72-80　2013/10/01

DOI： 10.1016/j.neuroimage.2013.04.015 　

ISSN： 1053-8119 1095-9572
Partial volume correction using structural-functional synergistic resolution recovery: comparison with geometric transfer matrix method Peer-reviewed

Euitae Kim, Miho Shidahara, Charalampos Tsoumpas, Colm J. McGinnity, Jun Soo Kwon, Oliver D. Howes, Federico E. Turkheimer

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　33　(6)　914-920　2013/06

DOI： 10.1038/jcbfm.2013.29 　

ISSN： 0271-678X

eISSN： 1559-7016
Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans. International-journal Peer-reviewed

Miho Shidahara, Manabu Tashiro, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Shoichi Watanuki, Kotaro Hiraoka, Masayasu Miyake, Ren Iwata, Hajime Tamura, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai

EJNMMI research　3　(1)　32-32　2013/04/24

DOI： 10.1186/2191-219X-3-32 　

More details Close

BACKGROUND: The biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe ([18F] FACT) was investigated in humans. METHODS: Six healthy subjects (three males and three females) were enrolled in this study. An average of 160.8 MBq of [18F] FACT was intravenously administered, and then a series of whole-body PET scans were performed. Nineteen male and 20 female source organs, and the remainder of the body, were studied to estimate time-integrated activity coefficients. The mean absorbed dose in each target organ and the effective dose were estimated from the time-integrated activity coefficients in the source organs. Biodistribution data from [18F] FACT in mice were also used to estimate absorbed doses and the effective dose in human subjects; this was compared with doses of [18F] FACT estimated from human PET data. RESULTS: The highest mean absorbed doses estimated using human PET data were observed in the gallbladder (333 ± 251 μGy/MBq), liver (77.5 ± 14.5 μGy/MBq), small intestine (33.6 ± 30.7 μGy/MBq), upper large intestine (29.8 ± 15.0 μGy/MBq) and lower large intestine (25.2 ± 12.6 μGy/MBq). The average effective dose estimated from human PET data was 18.6 ± 3.74 μSv/MBq. The highest mean absorbed dose value estimated from the mouse data was observed in the small intestine (38.5 μGy/MBq), liver (25.5 μGy/MBq) and urinary bladder wall (43.1 μGy/MBq). The effective dose estimated from the mouse data was 14.8 μSv/MBq for [18F] FACT. CONCLUSIONS: The estimated effective dose from the human PET data indicated that the [18F] FACT PET study was acceptable for clinical purposes.
呼吸性移動の影響を補正したSUV評価法に関する検討

小笠原誠, 伊藤謙吾, 志田原美保, 土橋卓, 武田賢, 角谷倫之, 藤田幸男, 南部武幸, 岸和馬, 金田朋洋, 神宮啓一

日本放射線技術学会東北部会雑誌　22　238-239　2013/01
Wavelet-based resolution recovery using an anatomical prior provides quantitative recovery for human population phantom PET [C-11]raclopride data Peer-reviewed

M. Shidahara, C. Tsoumpas, C. J. McGinnity, T. Kato, H. Tamura, A. Hammers, H. Watabe, F. E. Turkheimer

PHYSICS IN MEDICINE AND BIOLOGY　57　(10)　3107-3122　2012/05

DOI： 10.1088/0031-9155/57/10/3107 　

ISSN： 0031-9155

eISSN： 1361-6560
Wavelet-based resolution recovery using anatomical prior provides quantitative recovery for human population phantom PET [ 11C] raclopride data Peer-reviewed

Miho Shidahara, Charalampos Tsoumpas, Colm McGinnity, Takashi Kato, Hajime Tamura, Alexander Hammers, Hiroshi Watabe, Federico E. Turkheimer

IEEE Nuclear Science Symposium Conference Record　3097-3101　2012

DOI： 10.1109/NSSMIC.2011.6152561 　

ISSN： 1095-7863
In vivo Measurement of Longitudinal Relaxation Time of Human Blood by Inversion-recovery Fast Gradient-echo MR Imaging at 3T Peer-reviewed

Kazuki Shimada, Tatsuo Nagasaka, Miho Shidahara, Yoshio Machida, Hajime Tamura

MAGNETIC RESONANCE IN MEDICAL SCIENCES　11　(4)　265-271　2012

DOI： 10.2463/mrms.11.265 　

ISSN： 1347-3182
Positron emission tomography inter-scanner differences in dopamine D-2 receptor binding measured with [C-11]FLB457 Peer-reviewed

Fumitoshi Kodaka, Hiroshi Ito, Miho Shidahara, Harumasa Takano, Hidehiko Takahashi, Ryosuke Arakawa, Kazuhiko Nakayama, Tetsuya Suhara

ANNALS OF NUCLEAR MEDICINE　24　(9)　671-677　2010/11

DOI： 10.1007/s12149-010-0407-5 　

ISSN： 0914-7187
Quantitative analysis of dopamine transporters in human brain using [C-11]PE2I and positron emission tomography: evaluation of reference tissue models Peer-reviewed

Chie Seki, Hiroshi Ito, Tetsuya Ichimiya, Ryosuke Arakawa, Yoko Ikoma, Miho Shidahara, Jun Maeda, Akihiro Takano, Hidehiko Takahashi, Yuichi Kimura, Kazutoshi Suzuki, Iwao Kanno, Tetsuya Suhara

ANNALS OF NUCLEAR MEDICINE　24　(4)　249-260　2010/05

DOI： 10.1007/s12149-010-0364-z 　

ISSN： 0914-7187
Measurement error analysis for the determination of dopamine D-2 receptor occupancy using the agonist radioligand [C-11]MNPA Peer-reviewed

Miho Shidahara, Hiroshi Ito, Tatsui Otsuka, Yoko Ikoma, Ryosuke Arakawa, Fumitoshi Kodaka, Chie Seki, Harumasa Takano, Hidehiko Takahashi, Federico E. Turkheimer, Yuichi Kimura, Iwao Kanno, Tetsuya Suhara

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　30　(1)　187-195　2010/01

DOI： 10.1038/jcbfm.2009.193 　

ISSN： 0271-678X
A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies Peer-reviewed

Hiroshi Ito, Takashi Yokoi, Yoko Ikoma, Miho Shidahara, Chie Seki, Mika Naganawa, Hidehiko Takahashi, Harumasa Takano, Yuichi Kimura, Masanori Ichise, Tetsuya Suhara

NEUROIMAGE　49　(1)　578-586　2010/01

DOI： 10.1016/j.neuroimage.2009.07.021 　

ISSN： 1053-8119
The combination of S-1 and Oxaliplatin enhance the antitumor activity in vivo and in vitro in a human ovarian cancer model Peer-reviewed

地元祐輔, 仲田栄子, 駒村一樹, 長澤陽介, 渡邊重明, 斎藤春夫, 森一生, 田村元, 町田好男, 石橋忠司, 千田浩一, 志田原美保, 小山内実, 小倉隆英, 細貝良行, 川住祐介, 土橋卓, 高井良尋

Bulletin of School of Health Sciences, Tohoku University　19　(2)　107-115　2010
Publisher:
ISSN： 1348-8899
No regional difference in dopamine D-2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study Peer-reviewed

Hiroshi Ito, Ryosuke Arakawa, Hidehiko Takahashi, Harumasa Takano, Masaki Okumura, Tatsui Otsuka, Yoko Ikoma, Miho Shidahara, Tetsuya Suhara

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　12　(5)　667-675　2009/06

DOI： 10.1017/S1461145708009577 　

ISSN： 1461-1457
Improvement of likelihood estimation in Logan graphical analysis using maximum a posteriori for neuroreceptor PET imaging Peer-reviewed

Miho Shidahara, Chie Seki, Mika Naganawa, Muneyuki Sakata, Masatomo Ishikawa, Hiroshi Ito, Iwao Kanno, Kiichi Ishiwata, Yuichi Kimura

ANNALS OF NUCLEAR MEDICINE　23　(2)　163-171　2009/02

DOI： 10.1007/s12149-008-0226-0 　

ISSN： 0914-7187
Functional and structural synergy for resolution recovery and partial volume correction in brain PET Peer-reviewed

Miho Shidahara, Charalampos Tsoumpas, Alexander Hammers, Nicolas Boussion, Dimitris Visvikis, Tetsuya Suhara, Iwao Kanno, Federico E. Turkheimer

NEUROIMAGE　44　(2)　340-348　2009/01

DOI： 10.1016/j.neuroimage.2008.09.012 　

ISSN： 1053-8119

eISSN： 1095-9572
Optimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rate Peer-reviewed

Miho Shidahara, Hiroshi Watabe, Kyeong Min Kim, Nobuyuki Kudomi, Hiroshi Ito, Hidehiro Iida

ANNALS OF NUCLEAR MEDICINE　22　(8)　667-675　2008/10

DOI： 10.1007/s12149-008-0157-9 　

ISSN： 0914-7187
Error analysis for PET measurement of dopamine D(2) receptor occupancy by antipsychotics with [(11)C]raclopride and [(11)C]FLB 457 Peer-reviewed

Yoko Ikoma, Hiroshi Ito, Ryosuke Arakawa, Masaki Okumura, Chie Seki, Miho Shidahara, Hidehiko Takahashi, Yuichi Kimura, Iwao Kanno, Tetsuya Suhara

NEUROIMAGE　42　(4)　1285-1294　2008/10

DOI： 10.1016/j.neuroimage.2008.05.056 　

ISSN： 1053-8119
Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with F-18-FEDAA1106 Peer-reviewed

Miho Shidahara, Yoko Ikoma, Chie Seki, Yota Fujimura, Mika Naganawa, Hiroshi Ito, Tetsuya Suhara, Iwao Kanno, Yuichi Kimura

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　35　(2)　416-423　2008/02

DOI： 10.1007/s00259-007-0623-y 　

ISSN： 1619-7070
Body-contour versus circular orbit acquisition in cardiac SPECT: Assessment of defect detectability with channelized Hotelling observer Peer-reviewed

Antti Sohlberg, Hiroshi Watabe, Miho Shidahara, Hidehiro Lida

NUCLEAR MEDICINE COMMUNICATIONS　28　(12)　937-942　2007/12

DOI： 10.1097/MNM.0b013e3282f1b9a3 　

ISSN： 0143-3636
Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics

Yoko Ikoma, Hiroshi Ito, Ryosuke Arakawa, Masaki Okumura, Miho Shidahara, Chie Seki, Hidehiko Takahashi, Harumasa Takano, Yuichi Kimura, Tetsuya Suhara, Iwao Kanno

Journal of Cerebral Blood Flow and Metabolism　27　(1)　PP01-07　2007/11/13

ISSN： 0271-678X
Wavelet denoising for parametric imaging of the peripheral benzodiazepine receptors with F-18-FEDAA1106

Miho Shidahara, Yoko Ikoma, Chie Seki, Yota Fujimura, Hiroshi Ito, Yuichi Kimura, Tetsuya Suhara, Iwao Kanno

Journal of Cerebral Blood Flow and Metabolism　27　(1)　PO04-03　2007/11/13

ISSN： 0271-678X
Mapping of central dopamine synthesis in man, using positron emission tomography with L-[beta-C-11]DOPA Peer-reviewed

Hiroshi Ito, Miho Shidahara, Harurnasa Takano, Hidehiko Takahashi, Shoko Nozaki, Tetsuya Suhara

ANNALS OF NUCLEAR MEDICINE　21　(6)　355-360　2007/08

DOI： 10.1007/s12149-007-0033-z 　

ISSN： 0914-7187
高齢健常人におけるbaPWVと脳の形態変化との相関

大沢伸一郎, 瀧靖之, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 内田信也, 志田原美保, 木之村重男, 福田寛

Radiation Medicine　25　(Suppl.I)　29-29　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043

eISSN： 1862-5274
Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method Peer-reviewed

Mika Naganawa, Hideo Tsukada, Hiroyuki Ohba, Kiichi Ishiwata, Chie Seki, Miho Shidahara, Yuichi Kimura

IEEE Nuclear Science Symposium Conference Record　6　4510-4512　2007

DOI： 10.1109/NSSMIC.2007.4437112 　

ISSN： 1095-7863
Development of a digital phantom for evaluation of fundamental performance on SPECT Peer-reviewed

Nobutoku Motomura, Koichi Ogawa, Miho Shidahara, Hideo Onishi

IEEE Nuclear Science Symposium Conference Record　6　4524-4527　2007

DOI： 10.1109/NSSMIC.2007.4437115 　

ISSN： 1095-7863
Evaluation of optimal scan time by bootstrap approach for quantitative analysis in PET receptor study Peer-reviewed

Yoko Ikoma, Miho Shidahara, Hiroshi Ito, Chie Seki, Tetsuya Suhara, Iwao Kanno

IEEE Nuclear Science Symposium Conference Record　4　2131-2133　2007

DOI： 10.1109/NSSMIC.2006.354335 　

ISSN： 1095-7863
Quantitative mapping of basal and vasareactive cerebral blood flow using split-dose I-123-iodoamphetamine and single photon emission computed tomography Peer-reviewed

Kyeong Min Kim, Hiroshi Watabe, Takuya Hayashi, Kohei Hayashida, Tetsuro Katafuchi, Naoyuki Enomoto, Toshiyuki Ogura, Miho Shidahara, Shugo Takikawa, Stefan Eberl, Mayumi Nakazawa, Hidehiro Iida

NEUROIMAGE　33　(4)　1126-1135　2006/12

DOI： 10.1016/j.neuroimage.2006.06.064 　

ISSN： 1053-8119
高齢健常人におけるbaPWVと脳の形態変化との相関

大沢伸一郎, 瀧靖之, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 内田信也, 志田原美保, 木之村重男, 福田寛

核医学　43　(4)　340-340　2006/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Predicting human performance by channelized Hotelling observer in discriminating between Alzheimer's dementia and controls using statistically processed brain perfusion SPECT Peer-reviewed

Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Hiroshi Watabe, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shigeo Kinomura, Shinichiro Osawa, Yoshimi Onishi, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

ANNALS OF NUCLEAR MEDICINE　20　(9)　605-613　2006/11

DOI： 10.1007/BF02984658 　

ISSN： 0914-7187
Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: Comparison of radiopharmaceuticals marketed by different companies in Japan Peer-reviewed

Hiroshi Ito, Tachio Sato, Hayato Odagiri, Kentaro Inoue, Miho Shidahara, Tetsuya Suhara, Jun Hatazawa, Hiroshi Fukuda

ANNALS OF NUCLEAR MEDICINE　20　(7)　493-498　2006/08

ISSN： 0914-7187
Database of normal human cerebral blood flow measured by SPECT: II. Quantification of I-123-IMP studies with ARG method and effects of partial volume correction Peer-reviewed

K Inoue, H Ito, M Shidahara, R Goto, S Kinomura, K Sato, Y Taki, K Okada, T Kaneda, H Fukuda

ANNALS OF NUCLEAR MEDICINE　20　(2)　139-146　2006/02

DOI： 10.1007/BF02985626 　

ISSN： 0914-7187
Evaluation of Optimal Scan Time by Bootstrap Approach for Quantitative Analysis in PET Receptor Study Peer-reviewed

Yoko Ikoma, Miho Shidahara, Hiroshi Ito, Chie Seki, Tetsuya Suhara, Iwao Kanno

2006 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOL 1-6　2131-2133　2006

ISSN： 1082-3654
Development of a practical image-based scatter correction method for brain perfusion SPECT: comparison with the TEW method Peer-reviewed

M Shidahara, H Watabe, KM Kim, T Kato, S Kawatsu, R Kato, K Yoshimura, H Iida, K Ito

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　32　(10)　1193-1198　2005/10

DOI： 10.1007/s00259-005-1791-2 　

ISSN： 1619-7070
Effects of tissue heterogeneity on cerebral vascular response to acetazolamide stress measured by an I-123-IMP autoradiographic method with single-photon emission computed tomography Peer-reviewed

H Ito, M Shidahara, K Inoue, R Goto, S Kinomura, Y Taki, K Okada, T Kaneta, K Sato, T Sato, H Fukuda

ANNALS OF NUCLEAR MEDICINE　19　(4)　251-260　2005/06

ISSN： 0914-7187
A comparison of human observers and a channelized hotelling observer in discriminating between Alzheimer's Dementia and controls using brain perfusion SPECT Peer-reviewed

Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shichiro Osawa, Shigeo Kinomura, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

IEEE Nuclear Science Symposium Conference Record　4　2148-2149　2005

DOI： 10.1109/NSSMIC.2005.1596759 　

ISSN： 1095-7863
A comparison of human observers and a channelized hotelling observer in discriminating between Alzheimer's dementia and controls using brain perfusion SPECT Peer-reviewed

Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shinichiro Osawa, Shigeo Kinomura, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

2005 IEEE Nuclear Science Symposium Conference Record, Vols 1-5　2148-2149　2005

ISSN： 1082-3654
Development of image-based scatter correction for brain perfusion SPECT study: Comparison with TEW method Peer-reviewed

M Shidahara, H Watabe, KM Kim, S Kawatsu, T Kato, H Iida

2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5　2652-2656　2004

ISSN： 1082-3654
Impact of image-based scatter correction for (IMP)-I-123-SPECT and SPM analysis Peer-reviewed

M Shidahara, H Watabe, KM Kim, S Kawatsu, R Kato, T Kato, H Iida, K Ito

QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI　(1265)　84-88　2004

DOI： 10.1016/j.ics.2004.04.027 　

ISSN： 0531-5131
Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities Peer-reviewed

KM Kim, A Varrone, H Watabe, M Shidahara, M Fujita, RB Innis, H Iida

JOURNAL OF NUCLEAR MEDICINE　44　(4)　512-519　2003/04

ISSN： 0161-5505
Development of a GSO detector assembly for a continuous blood sampling system Peer-reviewed

N Kudomi, E Choi, S Yamamoto, H Watabe, KM Kim, M Shidahara, M Ogawa, N Teramoto, E Sakamoto, H Iida

IEEE TRANSACTIONS ON NUCLEAR SCIENCE　50　(1)　70-73　2003/02

DOI： 10.1109/TNS.2002.807869 　

ISSN： 0018-9499
Development of image-based scatter correction for brain perfusion SPECT study: Comparison with TEW method

Miho Shidahara, Hiroshi Watabe, KyeongMin Kim, Shoji Kawatsu, Takashi Kato, Hidehiro Iida, Kengo Ito

IEEE Nuclear Science Symposium Conference Record　4　2652-2656　2003

ISSN： 1095-7863
Simulation study of noise property of CMRO2 quantitation methods with inhalation of O-15(2) Peer-reviewed

N Kudomi, H Watabe, Y Miyake, KM Kim, M Shidahara, K Hayashida, H Oka, M Sagou, Y Ishida, T Hayashi, H Iida

2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　1116-1117　2003

ISSN： 1082-3654
Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO(2) by using sequential administration of O-15-labeled compounds Peer-reviewed

M Shidahara, H Watabe, KM Kim, H Oka, M Sago, T Hayashi, Y Miyake, Y Ishida, K Hayashida, T Nakamura, H Iida

ANNALS OF NUCLEAR MEDICINE　16　(5)　317-327　2002/07

ISSN： 0914-7187
Impact of attenuation and scatter correction in SPECT for quantification of cerebral blood flow using 99mTc-ethyl cysteinate dimer Peer-reviewed

Miho Shidahara, Hiroshi Watabe, Kyeong Min Kim, Takenori Hachiya, Ichiro Sayama, Iwao Kanno, Takashi Nakamura, Hidehiro Iida

IEEE Transactions on Nuclear Science　49　(1 I)　5-11　2002/02

DOI： 10.1109/TNS.2002.998673 　

ISSN： 0018-9499
Development of a GSO detector assembly for a continuous blood sampling system Peer-reviewed

N Kudomi, E Choi, S Yamamoto, H Watabe, KM Kim, M Shidahara, H Iida

2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4　1255-1257　2002

ISSN： 1082-3654
SPECT collimator dependency of scatter and validation of transmission-dependent scatter compensation methodologies Peer-reviewed

Kyeong Min Kim, H. Watabe, M. Shidahara, Y. Ishida, H. Iida

IEEE Transactions on Nuclear Science　48　(3)　689-696　2001/06

DOI： 10.1109/23.940148 　

ISSN： 0018-9499
Noise reduction in PET attenuation correction using non-linear Gaussian filters Peer-reviewed

K Kitamura, H Iida, M Shidahara, S Miura, Kanno, I

IEEE TRANSACTIONS ON NUCLEAR SCIENCE　47　(3)　994-999　2000/06

DOI： 10.1109/23.856537 　

ISSN： 0018-9499
Consideration of backscatter photons for edge detection in SPECT

H. Watabe, M. Shidahara, K. M. Kim, H. Iida

IEEE Nuclear Science Symposium and Medical Imaging Conference　2　13/147　2000
Modeling strategy for background compensation in repeat cerebral blood flow quantitation with diffusible tracers

H. Iida, H. Watabe, M. Shidahara, K. Min Kim, S. Takikawa, T. Ogura, K. Hayashida, Y. Ishida

IEEE Nuclear Science Symposium and Medical Imaging Conference　3　18/39　2000
Internal absorbed dose estimation by a TLD method for F-18-FDG and comparison with the dose estimates from whole body PET Peer-reviewed

HM Deloar, T Fujiwara, M Shidahara, T Nakamura, A Yamadera, M Itoh

PHYSICS IN MEDICINE AND BIOLOGY　44　(2)　595-606　1999/02

DOI： 10.1088/0031-9155/44/2/021 　

ISSN： 0031-9155
Validation and optimization of the use of standardized arterial input function in N-isopropyl-p[ 123I]iodoamphetamine cerebral blood flow SPECT Peer-reviewed

Toshiyuki Ogura, Syugo Takikawa, Hisatoshi Saito, Mayumi Nakazawa, Miho Shidahara, Hidehiro Iida

Kakuigaku　36　(8)　879-890　1999

ISSN： 0022-7854
Estimation of absorbed dose for 2-[F-18]fluoro-2-deoxy-D-glucose using whole-body positron emission tomography and magnetic resonance imaging Peer-reviewed

HM Deloar, T Fujiwara, M Shidahara, T Nakamura, H Watabe, Y Narita, M Itoh, M Miyake, S Watanuki

EUROPEAN JOURNAL OF NUCLEAR MEDICINE　25　(6)　565-574　1998/06

DOI： 10.1007/s002590050257 　

ISSN： 0340-6997

Show all ︎Show first 5

Misc. 66

プラナー像定量のためのconjugate法における減弱・散乱線補正が定量精度に及ぼす影響の基礎検討

佐々木里奈, 筒井亮佑, 小田桐逸人, KIM KyeongMin, 渡部浩司, 志田原美保

核医学技術　40　2020

ISSN： 0289-100X
I-123 BMIPP経口投与による胸管シンチグラフィの基礎的検討

高浪健太郎, 小田桐逸人, 志田原美保, 高瀬圭

核医学　55　(Suppl.)　S172-S172　2018/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
ラットPETを用いたヒト内部被曝線量の非侵襲的推定手法の検討

志田原美保, 猪又嵩斗, 小山千莉, 船木善仁, 田代学, 古本祥三, 谷内一彦, 権田幸祐, 渡部浩司

核医学　54　(Suppl.)　S199-S199　2017/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854
NEMA NU4-2008に基づいた小動物用PET装置ClairvivoPETの性能評価

志田原美保, Nai Ying Hway, 四月朔日聖一, 石川洋一, 田代学, 古本祥三, 谷内一彦, 権田幸祐, 渡部浩司

核医学　53　(Suppl.)　S312-S312　2016/10
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Biomathematical modeling approach to predict clinical SUVR in amyloid PET imaging towards efficient radioligand discovery and development

Y. Arakawa, M. Shidahara, Y. Nai, S. Furumoto, C. Seki, N. Okamura, M. Tashiro, M. Tashiro, Y. Kudo, K. Yanai, K. Gonda, H. Watabe

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　42　S70-S70　2015/10

ISSN： 1619-7070

eISSN： 1619-7089
生体数学モデルを用いたアミロイドPETイメージングにおける臨床SUVR予測

荒川悠真, 志田原美保, Nai Ying Hwey, 古本祥三, 関千江, 岡村信行, 田代学, 工藤幸司, 谷内一彦, 権田幸祐, 渡部浩司

核医学　52　(3)　260-260　2015/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Noise Power Spectrum in PROPELLER MR Imaging Peer-reviewed

Sato K, Shidahara M, Goto M, Yanagawa I, Homma N, Mori I

Magn Reson Med Sci,　14　(3)　235-242　2015

DOI： 10.2463/mrms.2014-0071 　

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The noise power spectrum (NPS), an index for noise evaluation, represents the frequency characteristics of image noise. We measured the NPS in PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) magnetic resonance (MR) imaging, a nonuniform data sampling technique, as an initial study for practical MR image evaluation using the NPS. The 2-dimensional (2D) NPS reflected the k-space sampling density and showed agreement with the shape of the k-space trajectory as expected theoretically. Additionally, the 2D NPS allowed visualization of a part of the image reconstruction process, such as filtering and motion correction.
Measurement of Free Fraction in Plasma for Biomathematical Prediction of SUVR of Amyloid PET Radiotracers

Nai Y.-H., Shidahara M., Seki C., Watanuki S., Funaki Y., Ishikawa Y., Furumoto S., Watabe H.

CYRIC annual report　2014　73-77　2015
Publisher: Cyclotron and Radioisotope Center, Tohoku University
タウイメージング薬剤[18F]THK-5117を用いたPET臨床試験(速報)

田代学, 岡村信行, 古本祥三, 四月朔日, 聖一, 平岡宏太良, 古川勝敏, 志田原美保, 石木愛子, 冨田尚希, 松田林, 稲見暁惠, 武田和子, 三宅正泰, 船木善仁, 岩田錬, 工藤幸司, 荒井啓行, 谷内一彦

核医学　51　(1)　28-28　2014/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
アミロイドイメージング用PET薬剤[18F]FACTの内部被ばく線量評価

志田原美保, 田代学, 岡村信行, 古本祥三, 古川勝敏, 四月朔日聖一, 平岡宏太良, 三宅正泰, 岩田錬, 田村元, 荒井啓行, 工藤幸司, 谷内一彦

核医学　50　(2)　70-70　2013/05
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
フッ素標識アミロイドイメージング薬剤[18F]FACTの動態解析

田代学, 岡村信行, 古本祥三, 四月朔日, 聖一, 平岡宏太良, 古川勝敏, 志田原美保, 三宅正泰, 船木善仁, 岩田錬, 工藤幸司, 荒井啓行, 谷内一彦

核医学　50　(2)　70-70　2013/05
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Investigation of Renal Medullary Blood Flow Imaging in Human

Ohsaki Y., Mori T., Koizumi K., Shidahara M., Yagi A., Tashiro M., Iwata R., Oba I., Furushou M., Makiko C., Tanno M., Hiraoka K., Watanuki S., Ishikawa Y., Miyake M., Ito S.

CYRIC annual report　2012　146-148　2013
Publisher: Cyclotron and Radioisotope Center, Tohoku University
Radiation Dosimetry of the F-18 Labelled Amyloid Imaging Probe [18F]FACT in Humans

Shidahara M., Tashiro M., Okamura N., Furumoto S., Furukawa K., Watanuki S., Hiraoka K., Miyake M., Watabe H., Iwata R., Arai H., Kudo Y., Gonda K., Tamura H., Yanai K.

CYRIC annual report　2012　137-143　2013
Publisher: Cyclotron and Radioisotope Center, Tohoku University
Biodistribution and radiation dosimetry of F-18 labeled amyloid imaging probe [18F]FACT in humans

M. Shidahara, M. Tashiro, N. Okamura, S. Furumoto, K. Furukawa, S. Watanuki, K. Hiraoka, M. Miyake, R. Iwata, H. Tamura, H. Arai, Y. Kudo, K. Yanai

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　39　S407-S408　2012/10

ISSN： 1619-7070
Preliminary investigation of biomathematical modeling approach to predict clinical usefulness of PET amyloid imaging probes

M. Ito, M. Shidahara, S. Furumoto, C. Seki, N. Okamura, M. Tashiro, K. Yanai, Y. Kudo, H. Tamura

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　39　S388-S388　2012/10

ISSN： 1619-7070
Wavelet-based resolution recovery using an anatomical prior provides quantitative recovery for human population phantom PET [C-11]raclopride data

Miho Shidahara, Charalampos Tsoumpas, Colm McGinnity, Takashi Kato, Hajime Tamura, Alexander Hammers, Hiroshi Watabe, Federico Turkheimer

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　32　S138-S139　2012/08

ISSN： 0271-678X
アミロイドイメージング用PET薬剤[18F]FACTの体内分布および内部被曝線量評価

志田原美保, 田代学, 岡村信行, 古本祥三, 古川勝敏, 四月朔日聖一, 田村元, 岩田錬, 荒井啓行, 工藤幸司, 谷内一彦

核医学　49　(3)　S239-S239　2012/08
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
アミロイドイメージングを用いたアルツハイマー病発症リスク予測法の実用化に関する多施設臨床研究[¹⁸F]FACTを用いたアルツハイマー病診断における定量法の検討

田代学, 志田原美保, 志田原美保, 岡村信行, 古川勝敏, 古本祥三, 古本祥三, 平岡宏太良, 船木善仁, 四月朔日聖一, 三宅正泰, 冨田尚希, 石川洋一, 岩田錬, 田村元, 工藤幸司, 荒井啓行, 谷内一彦, 谷内一彦

アミロイドイメージングを用いたアルツハイマー病発症リスク予測法の実用化に関する多施設臨床研究平成23年度総括・分担研究報告書　2012
PET脳神経受容体画像化における最尤推定を用いたグラフィカル解析法の改良

志田原美保, 関千江, 長縄美香, 坂田宗之, 石川雅智, 伊藤浩, 菅野巌, 石渡喜一, 木村裕一

東北医学雑誌　123　(1)　2011

ISSN： 0040-8700
陽電子断層撮影装置(PET)を用いた脳神経受容体機能の定量解析 (東北大医学部保健学科紀要)

志田原美保, 田村元

東北大医学部保健学科紀要　20　(1)　1-16　2011/01
Publisher: 東北大学医学部保健学科
ISSN： 1348-8899
[11C]MNPAを用いたドーパミンD2受容体占有率測定における誤差解析

SHIDAHARA MIHO, ITO HIROSHI, OTSUKA TATSUYUKI, IKOMA YOKO, ARAKAWA RYOSUKE, KODAKA FUMITOSHI, SEKI CHIE, TAKANO HARUMASA, TAKAHASHI HIDEHIKO, TAMURA HAJIME, SUHARA TETSUYA

核医学　47　(3)　369-369　2010/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Correction of [11C]diprenorphine PET data for the partial-volume effect: Quantification of opioid receptor binding following spontaneous epileptic seizures

C. J. McGinnity, M. Shidahara, S. Keihaninejad, D. A. Riano Barros, I. S. Gousias, R. A. Heckemann, D. J. Brooks, M. J. Koepp, F. E. Turkheimer, A. Hammers

NEUROIMAGE　52　S209-S209　2010/08

DOI： 10.1016/j.neuroimage.2010.04.171 　

ISSN： 1053-8119
A noise reduction method for graphical analyses with KL-expansion during transient equilibrium condition

K. Sakaguchi, M. Naganawa, M. Sakata, M. Shidahara, C. Seki, K. Ishiwata, Y. Kimura

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　29　S333-S333　2009/10

ISSN： 0271-678X
Error analysis of dopamine D-2 receptor occupancy study with agonist ligand [C-11]MNPA

M. Shidahara, H. Ito, T. Otsuka, Y. Ikoma, C. Seki, F. Kodaka, R. Arakawa, H. Takano, H. Takahashi, Y. Kimura, I. Kanno, T. Suhara

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　29　S347-S347　2009/10

ISSN： 0271-678X
アミロイド前駆体蛋白遺伝子導入マウスにおける11C-PIB脳内結合の定量

関千江, 徳永正希, 服部聡子, 志田原美保, 中尾隆士, 岡内隆, 前田純, 樋口真人, 木村裕一, 須原哲也

核医学　46　(3)　262-262　2009/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
抗精神病薬投与時のドーパミンD₂レセプター占有率の脳内局所差に関する研究

ITO HIROSHI, SUHARA TETSUYA, TAKAHASHI HIDEHIKO, TAKANO HARUNARI, ARAKAWA RYOSUKE, OKUMURA MASAKI, OTSUKA TATSUYUKI, KODAKA FUMISATO, SHIDAHARA MIHO

精神薬療研究年報　(41)　17-18　2009/03
Publisher: (公財)先進医薬研究振興財団
ISSN： 1346-1702
Logan法における主成分分析を用いた雑音低減処理の評価

坂口和也, 長縄美香, 坂田宗之, 志田原美保, 関千江, 石渡喜一, 木村裕一

核医学　46　(3)　2009

ISSN： 0022-7854
Determination of starting point for Logan graphical analysis using run test to improve PET neuroreceptor quantification

OGAKI Hiroto, KIMURA Yuichi, NAGANAWA Mika, SAKATA Muneyuki, SHIDAHARA Miho, SUGA Mikio

IEICE technical report　108　(209)　27-31　2008/09/10
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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This study aims at developing an algorithm to estimate a starting point, t^*, for Logan Graphical Analysis (LGA). LGA is a popular algorithm for quantitative neuroreceptor imaging using a positron emission tomography, in which a gradient of linear relation between time activity curves in arterial blood and tissues of administrated radiopharmaceutical gives us a density of neuroreceptors. If t^* is given appropriately, signs of residuals of the line estimation becomes a random sequence. Thus, a run test, that is a nonparametric statistical test for randomness, can be expected to be apply for t^* estimation. From simulation, the run-test based algorithm is useful for neuroreceptor imaging with PET.
新しいグラフプロット法による脳神経受容体結合能の定量解析

伊藤浩, 横井孝司, 生駒洋子, 志田原美保, 関千江, 高橋英彦, 高野晴成, 木村裕一, 須原哲也

核医学　45　(3)　S227-S227　2008/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
異なるPET装置でのドーパミンD2受容体結合能の比較

KODAKA FUMISATO, ITO HIROSHI, TAKAHASHI HIDEHIKO, TAKANO HARUHISA, ARAKAWA RYOSUKE, OKUMURA MASAKI, OTSUKA TATSUYUKI, MIYOSHI MICHIE, SEKINE MIZUHO, SHIDAHARA MIHO, SUHARA TETSUYA

核医学　45　(3)　S237-S237　2008/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
抗精神病薬投与時ドーパミンD2レセプター占有率の脳内局所差の検討

ITO HIROSHI, ARAKAWA RYOSUKE, TAKAHASHI HIDEHIKO, TAKANO HARUNARI, OKUMURA MASAKI, OTSUKA TATSUYUKI, KODAKA FUMISATO, SHIDAHARA MIHO, SUHARA TETSUYA

核医学　45　(3)　S229-S229　2008/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Regional differences in occupancy of dopamine D-2 receptors by second-generation antipsychotics in humans measured using PET

Hiroshi Ito, R. Arakawa, H. Takahashi, H. Takano, M. Okumura, T. Otsuka, Y. Ikoma, M. Shidahara, T. Suhara

NEUROIMAGE　41　T188-T188　2008

DOI： 10.1016/j.neuroimage.2008.04.155 　

ISSN： 1053-8119
Quantification of C-11-PIB kinetics in mouse brain using metabolite-corrected arterial input function

Chie Seki, M. Tokunaga, S. Haffori, M. Shidahara, R. Nakao, J. Maeda, H. Toyama, T. Irie, M. Higuchi, T. Suhara, I. Kanno, Y. Kimura

NEUROIMAGE　41　T32-T32　2008

DOI： 10.1016/j.neuroimage.2008.04.206 　

ISSN： 1053-8119
PET脳神経受容体画像化におけるMAP推定を用いたグラフィカル解析法の提案

志田原美保, 関千江, 長縄美香, 坂田宗之, 石川雅智, 菅野巖, 石渡喜一, 木村裕一

日本生体医工学会大会プログラム・論文集(CD-ROM)　47th　2008
PET脳神経受容体画像化におけるMAP推定を用いたグラフィカル解析法の提案

志田原美保, 関千江, 長縄美香, 坂田宗之, 石川雅智, 菅野巌, 石渡喜一, 木村裕一

核医学　45　(3)　2008

ISSN： 0022-7854
連検定によるLogan法における開始時刻の決定

木村裕一, 大柿宏人, 大柿宏人, 長縄美香, 志田原美保, 坂田宗之, 石渡喜一, 菅幹生

核医学　45　(3)　2008

ISSN： 0022-7854
Reduction of noise-induced underestimation in Logan graphical analysis using scale invariant linear estimation

Muneyuki Sakata, Y. Kimura, M. Naganawa, M. Shidahara, C. Seki, K. Oda, K. Ishii, K. Ishiwata

NEUROIMAGE　41　T82-T82　2008

DOI： 10.1016/j.neuroimage.2008.04.051 　

ISSN： 1053-8119
Parametric Imaging of the total volume of distrihution using MAP estimation for logan graphical analysis

Miho Shidahara, Y. Kimura, C. Seki, M. Naganawa, M. Sakata, M. Ishikawa, H. Ito, T. Suhara, K. Ishiwata, I. Kanno

NEUROIMAGE　41　T83-T83　2008

DOI： 10.1016/j.neuroimage.2008.04.052 　

ISSN： 1053-8119
A new graphic plot method for determination of neuroreceptor binding in PET studies

Hiroshi Ito, T. Yokoi, Y. Ikoma, M. Shidahara, C. Seki, H. Takahashi, H. Takano, Y. Kimura, T. Suhara

NEUROIMAGE　41　T67-T67　2008

DOI： 10.1016/j.neuroimage.2008.04.037 　

ISSN： 1053-8119
PET kinetic analysis: error consideration of quantitative analysis in dynamic studies

Yoko Ikoma, Hiroshi Watabe, Miho Shidahara, Mika Naganawa, Yuichi Kimura

ANNALS OF NUCLEAR MEDICINE　22　(1)　1-11　2008/01

DOI： 10.1007/s12149-007-0083-2 　

ISSN： 0914-7187
microPET Focus220を用いたサルPET検査における吸収補正に関する検討

志田原美保, 寅松千枝, 岡内隆, 関千江, 長縄美香, 永井裕司, 伊藤浩, 大林茂, 木村裕一, 菅野巖

核医学　44　(3)　315　2007/10/30

ISSN： 0022-7854
The effect of activity outside the field of view in estimation of human neuroreceptor binding with PET.

T. Shiraishi, M. Shidahara, K. Tanimoto, A. Ando, T. Miyamoto, R. Koganezawa, H. Fukuda, K. Watanabe

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　34　S403-S403　2007/10

ISSN： 1619-7070
11C-Verapamil P糖タンパク機能画像化に対するクラスタリング動態法の適用

木村裕一, 長縄美香, 志田原美保, 関千江, 織田圭一, 石井賢二, 石渡喜一

核医学　44　(3)　314-314　2007/10
Publisher: (一社)日本核医学会
ISSN： 0022-7854
PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging

Miho Shidahara, Yoko Ikoma, Jeff Kershaw, Yuichi Kimura, Mika Naganawa, Hiroshi Watabe

ANNALS OF NUCLEAR MEDICINE　21　(7)　379-386　2007/09

DOI： 10.1007/s12149-007-0044-9 　

ISSN： 0914-7187
Development of a digital phantom for evaluation of fundamental performance on SPECT Peer-reviewed

Nobutoku Motomura, Koichi Ogawa, Miho Shidahara, Hideo Onishi

2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11　6　4524-+　2007

ISSN： 1082-3654
PET kinetic analysis - Pitfalls and a solution for the Logan plot

Yuichi Kimura, Mika Naganawa, Miho Shidahara, Yoko Ikoma, Hiroshi Watabe

ANNALS OF NUCLEAR MEDICINE　21　(1)　1-8　2007/01

ISSN： 0914-7187
PET kinetic analysis - compartmental model

Hiroshi Watabe, Yoko Ikoma, Yuichi Kimura, Mika Naganawa, Miho Shidahara

ANNALS OF NUCLEAR MEDICINE　20　(9)　583-588　2006/11

DOI： 10.1007/BF02984655 　

ISSN： 0914-7187
Quantitative Analysis of Receptors in Living Human Brain with Positron Emission Tomography

IKOMA Yoko, SHIDAHARA Miho, SEKI Chie, ITO Hiroshi, TAKAHASHI Hidehiko, SUHARA Tetsuya, KANNO Iwao

2006　(31)　17-20　2006/07/14
脳血流SPECT画像を用いたアルツハイマー病患者と正常者の弁別読影精度を数値解析で予測する試み (核医学)

志田原美保, 井上健太郎, 瀧靖之, 岡田賢, 後藤了以, 木之村重男, 福田寛, 丸山将浩, 荒井啓行

核医学　42　(3)　313-313　2005/09
Impact of image-based scatter correction for (IMP)-I-123-SPECT and SPM analysis

M Shidahara, H Watabe, KM Kim, T Kato, S Kawatsu, R Kato, K Yoshimura, H Iida, K Ito

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　31　S402-S402　2004/08

ISSN： 1619-7070
Usefulness of FDG-PET and AD-tsum method in diagnostic imaging of Alzheimer's disease

T Kato, K Ito, K Herholz, G Zuendorf, Y Abe, Y Washimi, Y Arahata, K Hatano, S Kawatsu, A Nagano-Saito, M Shidahara, K Iwai, T Yamada, T Kachi

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　31　S363-S363　2004/08

ISSN： 1619-7070
Impact of image-based scatter correction for IMP-SPECT and SPM analysis.

M Shidahara, H Watabe, K Kim, T Kato, S Kawatsu, R Kato, K Hatano, H Iida, K Ito

JOURNAL OF NUCLEAR MEDICINE　44　(5)　263P-263P　2003/05

ISSN： 0161-5505
3種類のPET用持続動脈血液中放射能濃度測定器を用いた脳血流量の評価

松本圭一, 松浦元, 坂本摂, 中本裕士, 河嶋秀和, 山本誠一, 渡部浩司, 飯田秀博, 志田原美保

核医学　40　(3)　2003

ISSN： 0022-7854
Development and application of a GSO detector assembly for a continuous blood sampling system.

N Kudomi, E Choi, H Watabe, KM Kim, M Shidahara, M Ogawa, N Teramoto, E Sakamoto, S Yamamoto, H Iida

JOURNAL OF NUCLEAR MEDICINE　43　(5)　229P-229P　2002/05

ISSN： 0161-5505
Utilization of dynamic sinogram using ECAT EXACT and 15O-labeled compounds for accurate rCBF, rOEF and rCMRO2.

M Shidahara, H Watabe, K Hayashida, K Kim, T Nakamura, T Kato, K Ito, H Iida

JOURNAL OF NUCLEAR MEDICINE　43　(5)　207P-208P　2002/05

ISSN： 0161-5505
Optimal scan time of O-15-labeled gas inhalation method for measurement of cerebral oxygen extraction fraction.

M Shidahara, H Watabe, K Kim, T Nakamura, T Kato, K Ito, H Iida

JOURNAL OF NUCLEAR MEDICINE　43　(5)　211P-211P　2002/05

ISSN： 0161-5505
Noise property of two CMRO2 quantitation methods with a short bolus inhalation of O-15(2).

N Kudomi, H Watabe, Y Miyake, KM Kim, M Shidahara, K Hayashida, N Oka, M Sagou, Y Ishida, T Hayahsi, H Iida

JOURNAL OF NUCLEAR MEDICINE　43　(5)　211P-211P　2002/05

ISSN： 0161-5505
Contribution of scatter correction in the kinetic analysis of a D2 receptor ligand with SPECT.

KM Kim, H Watabe, M Shidahara, Y Onishi, Y Yonekura, H Iida

JOURNAL OF NUCLEAR MEDICINE　42　(5)　217P-217P　2001/05

ISSN： 0161-5505
Effect of scatter correction on quantitative estimation in receptor ligand study with SPECT.

KM Kim, H Watabe, M Shidahara, A Varrone, M Fujita, RB Innis, H Iida

JOURNAL OF NUCLEAR MEDICINE　42　(5)　184P-184P　2001/05

ISSN： 0161-5505
Validation of shortening scan intervals in repeat measurement of cerebral blood flow with O-15 water and PET.

H Watabe, Y Kondoh, KM Kim, M Shidahara, H Iida

JOURNAL OF NUCLEAR MEDICINE　42　(5)　220P-220P　2001/05

ISSN： 0161-5505
Optimization and validation for quantitative brain perfusion imaging using Tc-99m ethyle cycteinate dimmer (ECD) and SPECT.

H Iida, M Shidahara, H Watabe, K Kitamura, KM Kim, T Hachiya

JOURNAL OF NUCLEAR MEDICINE　41　(5)　185P-185P　2000/05

ISSN： 0161-5505
Correction for the coincidence detections due to Compton scattering on 3-dimensional acquisition PET for the quantitative thorax measurement.

Y Narita, M Shidahara, T Nakamura, T Fujiwara, S Watanuki, M Miyake, M Itoh

JOURNAL OF NUCLEAR MEDICINE　39　(5)　98P-98P　1998/05

ISSN： 0161-5505
Internal dosimetry by TLD method and comparison with the result of whole body PET

HM Deloar, T Fujiwara, M Shidahara, T Nakamura, H Watabe, A Yamadera, M Itoh

JOURNAL OF NUCLEAR MEDICINE　39　(5)　187P-188P　1998/05

ISSN： 0161-5505
Radiation absorbed dose estimates for 2-[F-18]fluoro-2-deoxy-D-glucose by using whole body PET and MRI

HM Deloar, M Shidahara, T Fujiwara, T Nakamura, M Miyake, S Watanuki, M Itoh

JOURNAL OF NUCLEAR MEDICINE　38　(5)　957-957　1997/05

ISSN： 0161-5505
Compton Scattering Correction in 3D-PET Study Based on the Unfolding Method

Shidahara M., Nakamura T., Narita Y., Miyake M., Watanuki S., Fujiwara T., Itoh M.

CYRIC annual report　1997　117-122　1997
Publisher: Cyclotron and Radioisotope Center, Tohoku University
Radiation Absorbed Dose Estimation of 2-[F-18]Fluoro-2-Deoxy-D-Glucose Using Whole Body PET and Measured Organ Volume MRI

Deloar H. M., Shidahara M., Fujiwara T., Nakamura T., Miyake M., Watanuki S., Watabe H., Narita M., Itoh M.

CYRIC annual report　1996　135-140　1996
Publisher: Cyclotron and Radioisotope Center, Tohoku University

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Books and Other Publications 5

核医学検査技術学(改訂4版) (放射線技術学シリーズ)

大西, 英雄, 本村, 信篤, 松友, 紀和, 日本放射線技術学会

オーム社　2022/03/15

ISBN: 4274228266
図解診療放射線技術実践ガイド : 第一線で必ず役立つ知識・実践のすべて

遠藤, 啓吾, 杜下, 淳次, 小倉, 明夫, 片渕, 哲朗, 赤澤, 博之, 西谷, 源展

文光堂　2020/01

ISBN: 9784830642326
放射線技術学シリーズ核医学検査技術学改訂3版

大西英雄, 市原隆, 山本智朗, 日本放射線技術学会

オーム社　2016/05/21

ISBN: 4274218600
Neural Metabolism In Vivo, Advances in Neurobiology, Vol. 4

Choi In-Young, Gruetter Rolf, eds, Habib Zaidi, Miho Shidahara

Springer　2012/01/25
Encyclopedia of Computational Neuroscience

Shidahara M, Watabe H, Kanno I

Springer

Presentations 62

Prediction of time-activity curves by machine learning and biomathematical model for discovery and development of CNS PET ligands

Kyosei Sahashi, Itsuki Miyajima, Ayano Yoshikawa, Miho Shidahara

The13th Congress of the World Federation of Nuclear Medicine and Biology
Novel database of kinetic parameters in human brain for existing CNS-PET tracers

Itsuki Miyajima, Ayano Yoshikawa, Kyosei Sahashi, Miho Shidahara

The13th Congress of the World Federation of Nuclear Medicine and Biology
Development of the methodology to predict clinical PET images for efficient CNS PET radioligand development using serotonin targeting ligands

Ayano Yoshikawa, Itsuki Miyajima, Kyosei Sahashi, Kotaro Hiraoka, Miho Shidahara

The13th Congress of the World Federation of Nuclear Medicine and Biology
Preliminary investigation of point source tracking algorithm in planar imaging system for motion correction of moving subjects

Moe Nishikawa, Ayano Yoshikawa, Hiroshi Watabe, Miho Shidahara

The13th Congress of the World Federation of Nuclear Medicine and Biology
理工系から考える日本核医学会のダイバーシティ推進

志田原美保

第62回日本核医学会学術総会　2022/09/10
Merging Biomathematical modelling and Machine learning to predict time-activity curves for PET CNS radioligand development

Miho Shidahara, Chie Seki, Hiroshi Watabe

2021 VIRTUAL IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE　2021/10/23
PET創薬のための臨床画像予測技術の開発 -アミロイドPETにおける基礎検討-

志田原美保, 阿部祥樹

第59回日本核医学会学術総会　2019/11/03
PET創薬のための数理モデル構築の試み Invited

志田原美保

PETサマーセミナ2019 in 福島　2019/08/24
Prediction of rat brain PET image with [11C]raclopride data based on biomathematical modelling approach

Miho Shidahara, Sotaro Momosaki, Hiroshi Watabe, Nozomi Takai, Takemi Rokukawa, Koji Abe

Brain & Brain PET 2019　2019/07/06
Error propagation property of 5 partial volume correction algorithms for [18F]THK5351 PET imaging

Senri Oyama, Miho Shidahara, Benjamin A. Thomas, KEisuke Matsubara, Masanobu Ibaraki, Shoichi Watanuki, Hiroshi Watabe, Manabu Tashiro

Annual Congress of the European Association of Nuclear Medicine (EANM 2018)
脳を対象とした放射性薬剤の動態解析～基礎から最新の話題まで～ Invited

志田原美保

日本核医学技術学会第24回東北地方会　2018/09/01
PET臨床データ定量解析

志田原美保

第6回画像診断セミナー　2012/02/07
『[18F]FACTの体内分布及び内部被曝線量評価

志田原美保

第1回核医学画像解析研究会　2011/11/14
小動物用ピンホールSPECT装置の回転半径と体軸方向の有効視野の関係に関する検討

志田原美保, 犬伏正幸, 田村元, 渡部浩司, 村井知佳, 小泉満, 佐賀恒夫

第51回日本核医学会学術総会　2011/10/28
Wavelet-based resolution recovery using anatomical prior provides quantitative recovery for human population phantom PET [11C]raclopride data International-presentation

Shidahara M, Tsoumpas C, McGinnity CJ, Kato T, Tamura H, Hammers A, Watabe H, Turkheimer FE

IEEE Nuclear Science Symposium and Medical Imaging Conference　2011/10/23
縦緩和率・フリップ角空間分解能同時測定の一方法

田村元, 大田英輝, 永坂竜男, 伊藤謙吾, 志田原美保, 諏訪亨, 小森芳秋, 小原真

第39回日本磁気共鳴医学会大会　2011/09/29
Quantitation of Changes in Cerebral Blood Flow and Longitudinal Relaxation Rate (R1=1/T1) Induced by Mild Hyperoxia International-presentation

Tamura H, Nagasaka T, Shimada K, Nishikata J, Shidahara M, Mugikura S, Machida Y

Annual meeting of International Society of Magnetic Resonance in Medicine, Montreal　2011/05/05
PET臨床データ定量解析

志田原美保

第5回画像診断セミナー　2011/02/21
[11C]MNPAを用いたドーパミンD2受容体占有率測定における誤差解析

志田原美保, 伊藤浩, 大塚達以, 生駒洋子, 荒川亮介, 小高文聰, 関千江, 高野晴成, 高橋英彦, 木村裕一, 田村元, 菅野巖, 須原哲也

第50回日本核医学会学術総会　2010/11/11
核医学画像における医師の読影成績を数値解析で予測する試み

志田原美保

第38回日本放射線技術学会秋季学術大会第61回核医学分科会　2010/10/16
吸入酸素によるMRI信号変化の基礎研究：ヒト脳における血流量の変化

西片純基, 志田原美保, 田頭豊, 栗田準一郎, 永坂竜夫, 田村元

第38回日本放射線技術学会秋季学術大会　2010/10/14
脳組織の酸素濃度とMRI縦緩和時間

田村元, 永坂竜夫, 島田一生, 西片純基, 志田原美保

第14回酸素ダイナミクス研究会　2010/09/04
Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains International-presentation

Seki C, Higuchi M, Tokunaga M, Hattori S, Maruyama M, Shidahara M, Okauchi T, Nakao R, Maeda J, Kimura Y, Kanno I, Suhara T

Functional Neuroreceptor Mapping of the Living Brain (NRM2010)　2010/07/22
Correction Of [11C]Diprenorphine PET Data For The Partial-Volume Effect: Application to Quantification Of Opioid Receptor Binding Following Spontaneous Epileptic Seizures International-presentation

McGinnity CJ, Shidahara M, Keihaninejad S, Riano Barros DA, Gousias IS, Heckemann RA, Koepp MJ, Turkheimer FE, Hammers A

Functional Neuroreceptor Mapping of the Living Brain (NRM2010）　2010/07/22
Quantifiaction of opioid receptor availability following spontaneous epilepticseizures International-presentation

McGinnity CJ, Shidahara M, Keihaninejad S, Riano Barros DA, Gousias IS, Heckemann RA, Koepp MJ, Turkheimer FE, Hammers A

9th EUROPEAN CONGRESS ON EPILEPTOLOGY　2010/06/27
画像処理技術（２）

志田原美保

第3回核医学専門技師研修セミナー　2010/05/23
脳神経受容体測定の施設間較差について―レビュー―

志田原美保

脳ＰＥＴワークショップ　2010/04/09
PET臨床データ定量解析

志田原美保

第4回画像診断セミナー　2010/02/23
Functional and structural synergy for resolution recovery and partial volume correction in Brain PET International-presentation

Shidahara Miho

UK-Japan workshop "Multimodal Methods for Monitoring Function in the Brain　2010/01/26
脳PET画像の部分容積効果補正を目的とした形態画像の活用

志田原美保, Charalampos Tsoumpas, Alexander Hammers, Nicolas Boussion, Dimitris Visvikis, 伊藤浩, 木村裕一, 須原哲也, 菅野巖, Federico Turkheimer

志田原美保, Charalampos Tsoumpas, Alexander Hammers,Nicolas Boussion, Dimitris Visvikis, 伊藤浩, 木村裕一, 須原哲也,菅野巖, Federico Turkheimer　2009/10/01
単孔または５孔のピンホールコリメータを装着した小動物用ＳＰＥＣＴシステムの実用性能評価

犬伏正幸, 志田原美保, 村井知佳, 関千江, 辻厚至, 小泉満, 菅野巌, 佐賀恒夫

第49回日本核医学会総会　2009/10/01
ヒトNa+/I-共輸送タンパク(hNIS)遺伝子安定発現大腸癌細胞株マウス担癌モデルのレポーター遺伝子イメージング

村井知佳, 犬伏正幸, 志田原美保, 辻厚至, 小泉満, 北川善政, 佐賀恒夫

第49回日本核医学会総会　2009/10/01
Functional and structural synergy for resolution recovery and partial volume correction in Brain PET International-presentation

Shidahara Miho

UK PET SIG Meeting　2008/12/04
PET脳神経受容体画像化におけるMAP推定を用いたグラフィカル解析法の提案

志田原美保, 関千江, 長縄美香, 坂田宗之, 菅野巖, 石渡喜一, 木村裕一

第47回日本生体医工学会大会　2008/05/08
PET臨床データ定量解

志田原美保

PETデータ解析ゼミ　2008/03/19
,『(21)PET動態解析画像の画質改善について

志田原美保

次世代PET研究会　2008/01/21
サル脳FDG-PET動態解析における動脈採血省略法EPICA

長縄美香, 塚田秀夫, 大庭弘行, 石渡喜一, 関千江, 志田原美保, 木村裕一

第47回日本核医学会総会　2007/11/04
11C-Verapamil P糖タンパク機能画像化に対するクラスタリング動態法の適用

木村裕一, 長縄美香, 志田原美保, 関千江, 織田圭一, 石井賢二, 石渡喜一

第47回日本核医学会総会　2007/11/04
microPET Focus220を用いたサルPET検査における吸収補正に関する検討

志田原美保, 寅松千枝, 岡内隆, 関千江, 長縄美香, 永井裕司, 伊藤浩, 大林茂, 木村裕一, 菅野巖

第47回日本核医学会総会　2007/11/04
小動物PET定量解析における採血量を考慮した採血タイミングの検討

関千江, 徳永正希, 岡内隆, 志田原美保, 長縄美香, 伊藤浩, 樋口真人, 木村裕一

第47回日本核医学会総会　2007/11/04
PETを用いた脳内ドーパミンD2受容体の占有率測定における精度評価

生駒洋子, 伊藤浩, 志田原美保, 関千江, 木村裕一, 須原哲也, 菅野巖

第47回日本核医学会総会　2007/11/04
脳内ドーパミントランスポーターリガンド[11C]PE2Iの定量評価法の検討

関千江, 伊藤浩, 生駒洋子, 志田原美保, 高野晶寛, 高橋英彦, 菅野巖, 須原哲也

第46回日本核医学会総会　2006/11/04
,『[F-18]FEDAA1106によるレセプター結合能のパラメトリック画像計算の検討

志田原美保, 藤村洋太, 生駒洋子, 関千江, 伊藤浩, 鈴木和年, 菅野巖, 須原哲也

第46回日本核医学会総会　2006/11/04
Bootstrap法を用いたPET受容体計測における定量パラメータ推定精度の評価

生駒洋子, 志田原美保, 関千江, 伊藤浩, 須原哲也, 菅野巖

第46回日本核医学会総会　2006/11/04
PETを用いた脳内受容体結合能の定量精度評価法の検討

生駒洋子, 志田原美保, 伊藤浩, 関千江, 菅野巖, 須原哲也

第25回日本医用画像工学会大会　2006/07/21
脳血流ＳＰＥＣＴ画像を用いたアルツハイマー病患者と正常者の弁別読影精度を数値解析で予測する試み

志田原美保, 井上健太郎, 瀧靖之, 岡田賢, 後藤了以, 木之村重男, 伊藤浩, 福田寛, 丸山将浩, 荒井啓行

第45回日本核医学会総会　2005/11/11
IMP-SPECT検査を用いたアルツハイマー病診断に散乱線補正が及ぼす影響に関する検討

志田原美保, 加藤隆司, 伊藤浩, 河津省司, 福田寛, 伊藤健吾

第44回日本核医学会総会　2004/11/04
AD-tsum法によるアルツハイマー病診断の検討

加藤隆司, 伊藤健吾, 河津省司, 齋藤敦子, 籏野健太郎, 志田原美保, 桃崎壮太郎, 川角保広, 阿部祐士, 鷲見幸彦, 新畑豊, 岩井克成, 山田孝子, 加知輝彦, Kar

第43回日本核医学会総会　2003/11/27
安価で汎用性のあるmotion correciton 装置の開発と実用性の検討

河津省司, 志田原美保, 加藤隆司, 川角保徳, 籏野健太郎, 伊藤健吾

第43回日本核医学会総会　2003/11/27
脳SPECT検査における画像間格差補正法の比較検討

志田原美保, 河津省司, 加藤隆司, 加藤力雄, 長谷川みち代, 伊藤健吾

第43回日本核医学会総会　2003/10/27
IMP-SPECT検査とSPM解析における画像ベース散乱線補正法の有用性の検討

志田原美保, 河津省司, 加藤隆司, 渡部浩司, KyeongMin Kim, 飯田秀博, 加藤力雄, 伊藤健吾

第43回日本核医学会総会　2003/10/27
脳SPECT検査における画像ベース散乱線補正法の開発

志田原美保, 河津省司, 加藤隆司, 渡部浩司, KyeongMin Kim, 飯田秀博, 伊藤健吾

第43回日本核医学会総会　2003/10/27
健常者の脳糖代謝の加齢性変化に関する検討

加藤隆司, 伊藤健吾, 河津省司, 齋藤敦子, 籏野健太郎, 志田原美保, 桃崎壮太郎, 川角保広, 阿部祐士, 鷲見幸彦, 新畑豊, 岩井克成, 山田孝子, 加知輝彦

第43回日本核医学会総会　2003/10/27
脳酸素摂取率測定のためのO-15標識酸素ガス吸入検査の測定時間最適化

志田原美保, 渡部浩司, KyeongMin Kim, 飯田秀博

第42回日本核医学会総会　2002/11/04
15O-O2ガス吸入定性早期画像の意義

志田原美保, 渡部浩司, Kyeyong Kim, 飯田秀博

第41回日本核医学会総会　2001/10/17
ECAT EXACTを用いた15O検査システムの構築

志田原美保, 渡部浩司, KyeongMin Kim, 飯田秀博, 岡尚嗣, 佐合正義, 林拓也, 三宅義徳, 石田良雄, 林田孝平

第41回日本核医学会総会　2001/10/17
99mTc-ECD-ARG 法の再現性の検討

蜂谷武憲, 犬上篤, 飯田秀博, 志田原美保

第40回日本核医学会総会　2000/11/01
サブウインドウを用いた輪郭抽出法の最適化

志田原美保, 渡部浩司, Kyeyong Kim, 蜂谷武憲, 飯田秀博

第40回日本核医学会総会　2000/11/01
PRISM-2000 XP を用いた123I-IMP 脳血流SPECTの散乱線除去

蜂谷武憲, 犬上篤, 熊谷和子, 大村知巳, 吉田円, 佐藤亜結子, 横山絵里子, 飯田秀博, 志田原美保

第18回動態核医学研究会　2000/07/29
99mTc-ECD K1画像定量検査における吸収及び散乱線補正の効果

志田原美保, 飯田秀博, 菅野巖, 中村尚司, 蜂谷武憲

第39回日本核医学会総会　1999/10/05
アンフォールディングによる３次元ＰＥＴの散乱線補正

志田原美保, 成田雄一郎, 藤原竹彦, 三宅正泰, 四月朔日, 聖, 中村尚司

第38回日本核医学会総会　1998/10/14
アンフォールディングによる頭部ＰＥＴの散乱線補正法

志田原美保, 成田雄一郎, 藤原竹彦, 三宅正泰, 四月朔日, 聖, 中村尚司

第37回日本核医学会総会　1997/11/19

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Industrial Property Rights 1

ＳＰＥＣＴ断層画像補正方法、システム、およびプログラム

伊藤健吾, 加藤隆司, 河津省司, 志田原美保

特許第3660998号

Property Type: Patent

Research Projects 16

フリームービング小動物PET検査が拓く脳基礎研究の新展開

志田原美保, 古本祥三, 渡部浩司, 茨木正信

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04/01 - 2027/03/31
認知症モデルマーモセットの産出と評価

代表, 関和彦

System: 日本医療研究開発機構研究費

Category: 革新的技術による脳機能ネットワークの全容解明プロジェクト(革新脳)

Institution: 国立精神・神経医療研究センター

2023/04 - 2024/03
PET創薬デジタルトランスフォーメーションを加速する画像予測技術開発

志田原美保

System: 内藤記念科学奨励金・研究助成

2021/10 - 2023/09
複数個体を対象とする動物PET体動補正で実現する無麻酔・非拘束な生体機能評価

志田原美保

Offer Organization: 日本学術振興会

System: 科学研究費助成事業挑戦的研究(萌芽)

Category: 挑戦的研究(萌芽)

Institution: 東北大学

2021/07/09 - 2023/03/31

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病態解明・創薬・難治疾患の治療法開発などの基礎研究を目的として、様々な動物種、遺伝子改変動物、病態モデル動物などを対象としたPET(陽電子断層撮影)検査が麻酔下/拘束条件で実施されている。本研究では、放射性マーカーのトラッキング技術と体動補正技術を融合した複数個体を対象とする動物PET検査により、麻酔・拘束具が不要な真にストレスフリー状態の小動物の統計的な生体機能評価の実現に取り組む。令和3年度は、放射性マーカーのトラッキング基盤技術開発を行った。マーカートラッキング技術開発のため、プナラーイメージング装置で複数のNa-22の密封線源を連動・計測する基礎実験を行った。この実験で得られた2次元ダイナミック画像に含まれる放射性マーカーを画像処理により検知し時系列にマーカー位置を追跡する基本アルゴリズムの構築を行った。その結果、高検出率でマーカー追跡が可能となった。次年度は、計画中の放射性マーカーの作成、動物用ケージの作成を行い、ストレスフリーラットの生体機能評価実験に向けた検討を進める予定である。
Novel concept of IVR system based on object identification in X-ray fluroscopic images for drastic dose reduction

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2019/04/01 - 2023/03/31
PET-NIRS fusion imaging for advanced diagnosis of Alzheimer's disease and elucidation of brain function

WATABE Hiroshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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For advanced diagnosis of brain functions, we developed a completely simultaneous measurement method of PET and NIRS. We validated the developed method using [O-15]water PET studies. We also proposed the Clinical Usefulness Index (CUI) value, which can objectively indicate the clinical evaluation of multiple tau protein PET drugs used for the diagnosis of Alzheimer's disease, and evaluated its effectiveness. In addition, we developed a database that can store a large number of modality data for use in multicenter studies.
Partial volume correction for Brain PET imaging

Shidahara Miho

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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Partial volume effect is inevitable phenomena in positron emission tomography (PET)imaging and degrade the quantification of PET images. Partial volume correction (PVC) will improve the quantification of PET images under the perfect condition which is difficult in real clinical study. We aimed to investigate error-propagation properties of PVC algorithms and know properties of PVCs on clinical PET images. We found that the even small error sources (eg. image-registration, segmentation), this surely propagate to the outcome and its amount is not small. In clinical data, different PVC algorithms provided difference amount of recovery and this tendency was also different among subject conditions. PVC is very sensitive with the mismatch between anatomy and PET images, so hybrid algorithms would be suitable for practical and robust PVC rather than anatomy-based method.
Development of new diagnostic method for dementia by fusion of PET and NIRS

WATABE HIROSHI, KUBO Hitoshi, WATANUKI Seiichi, SHIDAHARA Miho

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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In order to dramatically improve the diagnostic ability of Alzheimer's disease, this study aims to develop a new diagnostic method for PET amyloid β imaging agent and construct a fusion system of PET image and NIRS data. Based on the chemical form of the agent, we could predicted PET data for sevral PET amyloid pharmaceuticals, and derived CUI (clinical usefulness index) to evaluate its diagnostic ability. We also developed a PET/NIRS fusion system using an optical tracking device and evaluated its effectiveness by clinical experiments. As a result, PET and NIRS data were displayed in the same coordinate system in the brain, and analysis of both modalities could be merged.
In situ cancer therapy imaging by the OpenPET

Yamaya Taiga, Takahashi Hiroyuki, Haneishi Hideaki, Suga Mikio, Kawai Hideyuki, Shidahara Miho, Yoshida Eiji, Inadama Naoko, Nishikido Fumihiko, Hirano Yoshiyuki, Ito Hiroshi, Tsuji Atsushi, Inaniwa Taku, Obata Takayuki, Kawahira Hiroshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

Category: Grant-in-Aid for Scientific Research (A)

Institution: National Institute of Radiological Sciences

2013/04/01 - 2016/03/31

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We developed the world’s first, open-type 3D PET scanner “OpenPET” for PET-image guided particle therapy such as in situ dose verification and/or direct tumor tracking by means of PET. Following our first idea of a dual-ring Open PET (DROP), we proposed the second-generation geometry, single-ring OpenPET (SROP), which is more efficient than the DROP in terms of a cost and sensitivity. In this project, we developed a SROP prototype based on a novel detector arrangement, in which block detectors originally forming a conventional PET scanner were axially shifted little by little.
Precise evaluation and optimization of the THK probe for tau imaging

FURUMOTO SHOZO, OKAMURA Nobuyuki, SHIDAHARA Miho

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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Alzheimer's disease (AD) is the most common form of dementia in the elderly. Abnormal deposition of phosphorylated tau is one of the key pathological changes in the AD brain. The purpose of this study is to optimize the chemical structure of THK tau PET probes that have been developed by us for imaging tau pathology in the AD brain with PET. One modification of the probe structure was replacement of the benzene ring to pyridinyl one. Another change was conformational optimization of the fluoropropanol side chain. S-enantiomer of the pyridinyl derivative showed better brain pharmacokinetics in normal mice. The optimized derivative indicated lower non-specific binding to white matter of the AD brain tissue samples. Clinical PET study using the optimized probe demonstrated that higher radioactivity uptakes were observed in the parahippocampal gyrus and inferior temporal gyrus. These results suggest the potential utility of the optimized THK tau probe.
Quantification of physiological parameters in brain PET: partial volume correction and denoising

SHIDAHARA Miho

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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Towards more accurate estimation of physiological brain function using PET, we developed the methodology SFS-RR (structural and functional synergy for resolution recovery), which improves image quality (both resolution and quantification) of PET image by using Wavelet transform and anatomical/structural information (MRI and brain atlas images). We evaluate the performance of the recovery strategy in the case of the quantification of dopaminegic function in striatal regions. The proposed methodology proved effective in the resolution recovery of small structures of brain [11C]raclopride PET images and the improvement is consistent across the anatomical variability of a simulated population (Shidahara et al, 2012).
Development and evaluation of quantification for BF-227 amyloid PET imaging.

KATO Takashi, SIDAHARA Miho, ITO Kengo, FUJIWARA Ken

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: National Center for Geriatrics and Gerontology

2010 - 2012

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The purpose of this study was to establish a method for evaluating quantitatively BF-227 amyloid PET. Spatial normalization using BF-227 template showed equal to or higher precision than spatial normalization using MRI template. The new method proposed in this study to determine cerebellar reference region is useful for making SUVR (standard uptake value ratio) image for BF-227 PET. Partial volume correction with resolution recovery did not discriminate the accumulation between the cortex and white matter. Further improvement of algorithm is necessary. The methods proved to be useful for BF-227 PET can be applied to other amyloid imaging tracers.
Structural and functional synergy for quantitative PET images

SHIDAHARA Miho

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: National Institute of Radiological Sciences

2009 - 2010

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Using a wavelet-based resolution recovery method named SFS-RR (structural and functional synergy for resolution recovery), we have demonstrated that the structural image effectively recovers the true signal in cortical areas (Shidahara et al., 2009). In the current work, we evaluate the performance of the recovery strategy in the case of the quantification of dopaminegic function in striatal regions. The proposed methodology proved effective in the resolution recovery of small structures of brain [^<11>C]raclopride PET images and the improvement is consistent across the anatomical variability of a simulated population.
Quantitative neuroreceptor imaging for mice using PET : development of micro litter ordered blood radioactivity counting system and the technique to omit arterial blood sampling

KIMURA Yuichi, TOYAMA Hiroshi, KITAMURA Keishi, HIGUCHI Makoto, SHIDAHARA Miho, HONTANI Hidekata, SEKI Chie, NISHIMOTO Takahiro, WADA Yasuhiro, NAGANAWA Mika, SAKAGUCHI Kazuya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: National Institute of Radiological Sciences

2008 - 2010

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In this study, the methods for radioactivity counting system for micro-liter ordered blood were investigated. Also, the algorithm to omit arterial blood sampling was studied. For fully quantitative functional imaging using positron emission tomography (PET), the radioactivity concentration in arterial blood is required, and therefore, arterial blood sampling should be conducted. However, due to the small size in mice, the arterial blood sampling is an issue for PET quantitative measurement. This study aimed to realize quantitative PET functional imaging for mice, the system to measure radioactivity concentration in a few micro-liter arterial blood and the algorithm fo reduce the noise in PET data derived from mice based on MAP estimation were investigated.
System of Image processing for quantitative brain PET images

SHIDAHARA Miho

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: National Institute of Radiological Sciences

2007 - 2008
核医学診断のための正常者脳画像データベースの構築とその応用に関する研究

古本美保

Offer Organization: 日本学術振興会

System: 科学研究費助成事業特別研究員奨励費

Category: 特別研究員奨励費

2003 - 2005

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本研究の目的は、放射性同位元素を用いた核医学検査の高精度診断に必要不可欠な大規模な正常者脳画像データベースを構築するため、データを募る各病院施設で撮影された画像間の較差を補正する技術を開発することである。本年度は、昨年度開発した画像処理に由来する画像間格差補正法の評価、また正常者データベースを用いた健常者、疾患者の自動弁別法の開発を行った。 1)散乱線補正に由来する画像間較差に対して提案手法が利用できることを確認した。この研究成果は、9月European Annual Meeting of Society of Nuclear Medicine(ヘルシンキ)、11月日本核医学会総会(京都)において発表され、論文として、ElsevierによるICS Congress Series 1265に掲載、European Journal of Nuclear Medicine and Molecular Imagingにacceptされた。また昨年出願した特許「SPECT断層画像補正方法,システム,およびプログラム」(出願番号2003-169809)に関しても査定が終了し特許取得が確定している。 2)正常者データベースを用いた健常者、疾患者核医学画像の自動弁別法を開発した。本年度は、核医学画像に対応した心理物理学の手法を用いたアルゴリズムの導入及びプログラム開発をおこない、自動画像弁別システムを構築した。この自動弁別法の導入により我々が開発している画像及び施設間較差補正方法が病気の診断にどれだけ有用であるか医師の診断を客観的に予測し評価できるようになる。この研究については、臨床の健常者、疾患データを用いた評価を次年度にひきつづき行う計画であり、またIEEE Nuclear Science and Medical Imaging Conferenceにおいてその成果を報告予定である。

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第16回核医学専門技師研修セミナー (画像処理2)

2023/04/17 - 2023/05/27
第7回放射線治療・物理学セミナー(放射線基礎物理)

2019/03/24 -

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Partial volume correction using Structural-Functional Synergistic Resolution Recovery: comparison with the geometric transfer matrix method

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Partial volume correction using Structural-Functional Synergistic Resolution Recovery: comparison with the geometric transfer matrix method
Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effec

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Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effec
核医学検査による腫瘍・血流イメージングに適応可能な汎用型自動診断法の開発

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核医学検査による腫瘍・血流イメージングに適応可能な汎用型自動診断法の開発