Details of the Researcher

PHOTO

Taiki Miyazawa
Section
New Industry Creation Hatchery Center
Job title
Specially Appointed Associate Professor(Research)
Degree

  • 博士（農学） (Tohoku University)

e-Rad No.
80814243
Researcher ID
G-5994-2014

Research History 9

  • 2022/04 - Present
    Tohoku University　New Industry Creation Hatchery Center　Project Associate Professor

  • 2020/04 - Present
    Tohoku University Graduate School of Agricultural Science　Associate Professor (additional post)

  • 2020/04 - 2022/03
    Tohoku University　New Industry Creation Hatchery Center　Associate professor

  • 2017/04 - 2020/03
    Japan Society for the Promotion of Science (JSPS) Fellowship (PD)　Tokyo medical and dental university

  • 2016/04 - 2017/03
    Tokyo Medical and Dental University　Institute of Biomaterials and Bioengineering　Project Assistant Professor

  • 2014/05 - 2016/03
    Japan Society for the Promotion of Science (JSPS) Post Doctoral Research Fellow for Research Abroad　Tufts University, Jean Mayer USDA Human Nutrition Research Center on Aging（HNRCA）

  • 2012/04 - 2014/03
    Japan Society for the Promotion of Science (JSPS) Doctoral Candidate Fellowship (DC2)　Tohoku University

  • 2009/10 - 2012/03
    Research Assistant, Tohoku University

  • 2009/09 - 2009/09
    Teaching Assistant at Tohoku University

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Education 3

  • Tohoku University　Graduate School, Division of Agriculture

    2011/04 - 2014/03

  • Tohoku University　Graduate School, Division of Agriculture

    2009/04 - 2011/03

  • Yamagata University　Faculty of Engineering　Department of Chemistry and Chemical Engineering

    2005/04 - 2009/03

Committee Memberships 7

  • Taylor & Francis, Food & Nutrition Research (FNR)　Early-Career Editorial Board

    2026/08 - Present

  • Oxford University Press, Nutrition Reviews　Editorial Board

    2025/10 - Present

  • MDPI, Antioxidants　Guest Editor

    2025/12 - 2027/02

  • MDPI, Antioxidants　Guest Editor

    2024/02 - 2025/10

  • MDPI, Foods　Guest Editor

    2024/02 - 2024/07

  • Taylor & Francis, International Journal of Nanomedicine　Guest advisor

    2023/11 - 2024/05

  • MDPI, Antioxidants　Guest Editor

    2022/05 - 2024/01

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Professional Memberships 6

  • 次世代医工学研究会

    - Present

  • American Society for Nutrition

    - Present

  • 日本農芸化学会

    - Present

  • The Japanese Society for Food Analysis

    - Present

  • 日本栄養食糧学会

    - Present

  • 日本化学会

    - Present

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Research Interests 13

  • カロテノイド

  • metabolism

  • metabolome analysis

  • Surfactant

  • Polyphenol

  • Curcumin

  • Redox balance

  • Liposome

  • Boronic acid

  • antioxidant

  • Tocopherols

  • Ascorbic acid

  • nanoparticles

Research Areas 4

  • Life sciences / Biomedical engineering /

  • Life sciences / Food sciences /

  • Life sciences / Nutrition and health science /

  • Nanotechnology/Materials / Biochemistry /

Awards 8

  1. Appreciation of outstanding lecture

    2024/03　Health Food Society of Taiwan　International Symposium on Future Perspectives for the Development of Precision Health Food at NKUST

  2. Top downloaded article 2022

    2024/03　Wiley　Food Bioengineering

  3. Among the journal’s most-cited articles within the past three years.​ | Taylor & Francis Group

    2023/07　Taylor & Francis Group

  4. Among the most highly cited in International Journal of Nanomedicine in the last five years,

    2022/06　Dove Medical Press | Taylor and Francis

  5. Top cited articles 2019-2020

    2021/04　IUBMB Life, Wiley

  6. Top downloaded paper 2018-2019

    2020/04　IUBMB Life, Wiley

  7. 東北大学大学院農学研究科長賞

    2014/03　東北大学

  8. 第一回関東支部若手奨励賞

    2013/12　日本油化学会

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Papers 56

  1. Characterization of Yellow and Red Pigments Associated with Soybean Reddening During Processing Peer-reviewed

    Shiori Idogawa, Serina Imaruoka, Taiki Miyazawa, Ohki Higuchi, Kazuaki Akasaka, Teruo Miyazawa

    Foods　15　(17)　3030-3030　2026/08/27

    Publisher: MDPI AG

    DOI： 10.3390/foods15173030 　

    eISSN： 2304-8158

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    Discoloration of soybean-based foods, particularly reddening during processing, remains poorly understood. In this study, yellow and red pigments associated with soybean reddening were extracted, purified, and characterized. The pigments showed distinct UV–Vis spectra, with a shoulder near 420 nm for the yellow pigment and an absorption maximum near 510 nm for the red pigment. Heat and pH stability experiments showed that the yellow pigment decreased during thermal treatment, accompanied by an increase in the red pigment. Mass spectrometric analyses revealed a consistent 2 Da mass difference and a common fragment ion, indicating a close structural relationship between the pigments. Both pigments were detected in soybean, soymilk, and tofu, and the red pigment increased during processing. The pigments did not correspond to known major soybean constituents. These findings suggest that soybean reddening involves the conversion of a yellow pigment into a structurally related red pigment during soybean processing.

  2. Effects of Fermentation and Oxidative Degradation on the Composition, Antioxidant Activity, ACE Inhibitory Activity, and In Vitro Neuroprotective Potential of Soybean-Derived Kefir Polysaccharide-Rich Extracts Peer-reviewed

    Wei-Cheng Hsiao, Taiki Miyazawa, Sue-Joan Chang, Yong-Han Hong, Yu-Chen Zhou, Man-Chu Deng, Teruo Miyazawa, Chun-Yung Huang

    Foods　15　(13)　2372-2372　2026/07/03

    Publisher: MDPI AG

    DOI： 10.3390/foods15132372 　

    eISSN： 2304-8158

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    Kefir is a probiotic beverage produced by symbiotic bacteria and yeasts. Polysaccharide-rich extracts from yellow and black soybeans (S and B) were obtained and subsequently fermented to produce S-F and B-F. The fermented extracts were further subjected to oxidative degradation using ascorbic acid and hydrogen peroxide to generate S-FD and B-FD. Physicochemical analyses revealed distinct differences in composition, phenolic profiles, and molecular weight among S-F, S-FD, B-F, and B-FD. Fourier transform infrared (FTIR) spectra indicated that oxidative degradation altered specific functional group intensities without disrupting the fundamental polysaccharide framework. Fermentation enhanced angiotensin-converting enzyme (ACE) inhibitory activity, and subsequent oxidative degradation further improved this effect. Both fermented and degraded extracts exhibited antioxidant activities, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging capacity, ferrous-ion chelating ability, and reducing power, with degraded samples showing greater activity. The effects of the extracts on SH-SY5Y human neuroblastoma cells were evaluated in vitro. No cytotoxicity was observed at concentrations up to 400 μg/mL. Treatment at 200 μg/mL increased cell viability and reduced apoptosis in rotenone (ROT)-treated cells. Multivariate analysis further indicated that oxidative degradation enhanced antioxidant and ACE inhibitory activities but may reduce the protective effects observed in SH-SY5Y cells. Overall, soybean-derived kefir polysaccharide-rich extracts show potential as functional ingredients for applications related to blood pressure regulation and antioxidant activity, while their protective effects in neuronal cell models warrant further investigation.

  3. Lipid Composition Analysis of Cricket Oil from Crickets Fed with Broken Rice-Derived Bran Peer-reviewed

    Ryosuke Sogame, Taiki Miyazawa, Masako Toda, Akihiro Iijima, Maharshi Bhaswant, Teruo Miyazawa

    Insects　16　(9)　951-951　2025/09/11

    Publisher: MDPI AG

    DOI： 10.3390/insects16090951 　

    eISSN： 2075-4450

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    This study investigated the effect of rice bran derived from broken rice feeding on the lipid classes and fatty acid composition of oil extracted from crickets (Acheta domesticus). During the final seven days prior to cricket oil extraction, crickets were fed either rice bran or control feed. The lipid classes in both the cricket oil and feed materials (rice bran or control feed) were identified using thin-layer chromatography, while the proportion of neutral lipids, phospholipids, and glycolipids was quantified by solid-phase extraction. Fatty acid composition was determined using GC-FID. Cricket oil from the rice bran-fed group exhibited a significantly higher ratio of glycolipids, which are abundant in rice bran, compared to the control group. Although both oleic and linoleic acid levels were significantly higher than in the control feed, only the oleic acid proportion was significantly increased in the cricket oil from the rice bran-fed group. Additionally, the ω-6/ω-3 ratio in each lipid fraction was significantly higher in the rice bran-fed group compared to the control group. These results suggest that dietary supplementation with rice bran derived from broken rice significantly alters the lipid profile of crickets and may represent a valuable strategy for enhancing the nutritional quality of cricket oil.

  4. Comparative analysis of microgreens and germinated seeds from three Brassicaceae cultivars: Macro- and micro-nutrient and glucosinolate composition Peer-reviewed

    Maharshi Bhaswant, Taiki Miyazawa, Chizumi Abe, Ritsuko Fukasawa, Ohki Higuchi, Teruo Miyazawa

    Journal of Food Composition and Analysis　144　107673-107673　2025/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.jfca.2025.107673 　

    ISSN： 0889-1575

  5. Determination of Plasmalogen Molecular Species in Hen Eggs Peer-reviewed

    Taiki Miyazawa, Ohki Higuchi, Ryosuke Sogame, Teruo Miyazawa

    Molecules　29　(20)　4795-4795　2024/10/10

    Publisher: MDPI AG

    DOI： 10.3390/molecules29204795 　

    eISSN： 1420-3049

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    (1) Background: Plasmalogens are vinyl ether-type glycerophospholipids that are characteristically distributed in neural tissues and are significantly reduced in the brains of individuals with dementia compared to those in healthy subjects, suggesting a link between plasmalogen deficiency and cognitive decline. Hen eggs are expected to be a potential source of dietary plasmalogens, but the details remain unclear. (2) Methods: We evaluated the fresh weight, dry weight, total lipid, neutral lipids, glycolipids, and phospholipids in the egg yolk and egg white of hen egg. Then, the molecular species of plasmalogens were quantified using HPLC-ESI-MS/MS. (3) Results: In egg yolk, the total plasmalogen content was 1292.1 µg/100 g fresh weight and predominantly ethanolamine plasmalogens (PE-Pls), specifically 18:0/22:6-PE-Pls, which made up 75.6 wt% of the total plasmalogen. In egg white, the plasmalogen content was 31.4 µg/100 g fresh weight and predominantly PE-Pls, specifically 18:0/20:4-PE-Pls, which made up 49.6 wt% of the total plasmalogen. (4) Conclusions: Plasmalogens were found to be more enriched in egg yolk than in egg white. It was found that humans are likely to ingest almost 0.3 mg of total plasmalogens from one hen egg. These findings highlight the importance of plasmalogens in the daily diet, and it is recommended to explore the impact of long-term dietary plasmalogen intake to assess its effect on human health. This provides a viewpoint for the development of new food products.

  6. Comparative analysis of macro- and micro-nutrients of Perilla frutescens var. crispa f. viridis microgreens and germinated seeds Peer-reviewed

    Maharshi Bhaswant, Taiki Miyazawa, Chizumi Abe, Ritsuko Fukasawa, Ohki Higuchi, Minh Tu Nguyen Thi, Teruo Miyazawa

    Food Chemistry　139858-139858　2024/05

    Publisher: Elsevier BV

    DOI： 10.1016/j.foodchem.2024.139858 　

    ISSN： 0308-8146

  7. Simultaneous Intake of Chlorella and Ascidian Ethanolamine Plasmalogen Accelerates Activation of BDNF–TrkB–CREB Signaling in Rats Peer-reviewed

    Hideo Takekoshi, Masaki Fujishima, Taiki Miyazawa, Ohki Higuchi, Takahiko Fujikawa, Teruo Miyazawa

    Molecules　29　(2)　357-357　2024/01/11

    Publisher: MDPI AG

    DOI： 10.3390/molecules29020357 　

    eISSN： 1420-3049

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    Brain-derived neurotrophic factor (BDNF) plays an important role in neurogenesis, synaptic plasticity, and cognition. BDNF is a neurotrophin that binds to tropomyosin receptor kinase B (TrkB), a specific receptor on target cell surfaces; it acts on neuronal formation, development, growth, and repair via transcription factors, such as cAMP response element-binding protein (CREB), and it is involved in learning and memory. BDNF expression is decreased in patients with Alzheimer’s disease (AD). Exercise and the intake of several different foods or ingredients can increase BDNF expression, as confirmed with lutein, xanthophylls (polar carotenoids), and ethanolamine plasmalogen (PlsEtn), which are present at high levels in the brain. This study examined the effects of combining lutein and PlsEtn using lutein-rich Chlorella and ascidian extracts containing high levels of PlsEtn bearing docosahexaenoic acid, which is abundant in the human brain, on the activation of the BDNF–TrkB–CREB signaling pathway in the hippocampus of Sprague-Dawley rats. Although activation of the BDNF–TrkB–CREB signaling pathway in the hippocampus was not observed in Chlorella or ascidian PlsEtn monotherapy, activation was observed with combination therapy at an equal dose. The results of this study suggest that the combination of Chlorella and ascidian PlsEtn may have a preventive effect against dementia, including AD.

  8. Functional components of walnuts: a review focusing on native and cultivated species Peer-reviewed

    Ritsuko Fukasawa, Taiki Miyazawa, Chizumi Abe, Maharshi Bhaswant, Masako Toda

    Food Science and Technology Research　30　(1)　1-12　2024/01

    Publisher: Japanese Society for Food Science and Technology

    DOI： 10.3136/fstr.fstr-d-23-00093 　

    ISSN： 1344-6606

    eISSN： 1881-3984

  9. Quantification and Comparison of Nutritional Components in Oni Walnut (Juglans ailanthifolia Carr.), Hime Walnut (Juglans subcordiformis Dode.), and Cultivars Peer-reviewed

    Ritsuko Fukasawa, Taiki Miyazawa, Chizumi Abe, Maharshi Bhaswant, Masako Toda

    Horticulturae　9　(11)　1221-1221　2023/11/11

    Publisher: MDPI AG

    DOI： 10.3390/horticulturae9111221 　

    eISSN： 2311-7524

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    Walnuts are rich sources of lipids and polyunsaturated fatty acids and are expected to promote health. There are two Japanese native walnut species: Oni walnut (Juglans ailanthifolia Carr.) and Hime walnut (Juglans subcordiformis Dode.). However, despite the fact that these Japanese native walnuts have long been consumed in local cuisine, their nutritional composition is largely unknown. This study aimed to assess the concentrations of total lipids, and fatty acid composition including polyunsaturated fatty acids, in the kernels of Oni walnut and Hime walnut. In addition, we assessed various aspects related to their nutritional and functional values, by measuring the total protein, amino acids, minerals, and total polyphenols. The concentrations of the measured compounds in the two native species were compared with those in the English walnut (Juglans regia L.), a globally recognized cultivar, and its counterpart cultivated in Japan, Shinano walnut (Juglans regia L.). The results showed that Oni walnut and Hime walnut contained significantly higher protein and minerals and lower lipid content than conventional cultivars. However, both Oni and Hime walnuts contained higher ratios of unsaturated fatty acids in total fatty acids. This study offers novel insights into the nutritional components of Oni and Hime walnuts, contributing to a deeper understanding of their nutritional value and potential applications as unique native walnut species. The findings of this study highlight the relationship between the different types of walnut species and their nutritional composition, and the value of native walnuts used in local cuisine, and will lead to new developments in functional foods from walnut species consumed around the world. It will contribute to the development of functional and processed foods by increasing the production of native walnut species, which are rich in protein, unsaturated fatty acids and minerals and by using them in local cuisines and health-promoting foods.

  10. Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases Peer-reviewed

    Shinji Yamashita, Taiki Miyazawa, Ohki Higuchi, Mikio Kinoshita, Teruo Miyazawa

    Molecules　28　(17)　6328-6328　2023/08/29

    Publisher: MDPI AG

    DOI： 10.3390/molecules28176328 　

    eISSN： 1420-3049

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    Aging increases oxidative and inflammatory stress caused by a reduction in metabolism and clearance, thus leading to the development of age-associated diseases. The quality of our daily diet and exercise is important for the prevention of these diseases. Marine resources contain various valuable nutrients, and unique glycerophospholipid plasmalogens are found abundantly in some marine invertebrates, including ascidians. One of the major classes, the ethanolamine class (PlsEtn), exists in a high ratio to phospholipids in the brain and blood, while decreased levels have been reported in patients with age-associated diseases, including Alzheimer’s disease. Animal studies have shown that the administration of marine PlsEtn prepared from marine invertebrates improved PlsEtn levels in the body and alleviated inflammation. Animal and human studies have reported that marine PlsEtn ameliorates cognitive impairment. In this review, we highlight the biological significance, relationships with age-associated diseases, food functions, and healthcare materials of plasmalogens based on recent knowledge and discuss the contribution of marine plasmalogens to health maintenance in aging.

  11. Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice Peer-reviewed

    Chaoqi He, Taiki Miyazawa, Chizumi Abe, Takahiro Ueno, Mikiko Suzuki, Masashi Mizukami, Kazue Kurihara, Masako Toda

    International Journal of Molecular Sciences　24　(11)　9366-9366　2023/05/27

    Publisher: MDPI AG

    DOI： 10.3390/ijms24119366 　

    eISSN： 1422-0067

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    Turmeric (Curcuma longa) contains various compounds that potentially improve health. Bisacurone is a turmeric-derived compound but has been less studied compared to other compounds, such as curcumin. In this study, we aimed to evaluate the anti-inflammatory and lipid-lowering effects of bisacurone in high-fat diet (HFD)-fed mice. Mice were fed HFD to induce lipidemia and orally administered bisacurone daily for two weeks. Bisacurone reduced liver weight, serum cholesterol and triglyceride levels, and blood viscosity in mice. Splenocytes from bisacurone-treated mice produced lower levels of the pro-inflammatory cytokines IL-6 and TNF-α upon stimulation with a toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS), and TLR1/2 ligand, Pam3CSK4, than those from untreated mice. Bisacurone also inhibited LPS-induced IL-6 and TNF-α production in the murine macrophage cell line, RAW264.7. Western blot analysis revealed that bisacurone inhibited the phosphorylation of IKKα/β and NF-κB p65 subunit, but not of the mitogen-activated protein kinases, p38 kinase and p42/44 kinases, and c-Jun N-terminal kinase in the cells. Collectively, these results suggest that bisacurone has the potential to reduce serum lipid levels and blood viscosity in mice with high-fat diet-induced lipidemia and modulate inflammation via inhibition of NF-κB-mediated pathways.

  12. The Potential Use of Exosomes in Anti-Cancer Effect Induced by Polarized Macrophages Peer-reviewed

    Chizumi Abe, Maharshi Bhaswant, Teruo Miyazawa, Taiki Miyazawa

    Pharmaceutics　15　(3)　1024-1024　2023/03/22

    Publisher: MDPI AG

    DOI： 10.3390/pharmaceutics15031024 　

    eISSN： 1999-4923

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    The rapid development of aberrant cells outgrowing their normal bounds, which can subsequently infect other body parts and spread to other organs—a process known as metastasis—is one of the significant characteristics of cancer. The main reason why cancer patients die is because of widespread metastases. This abnormal cell proliferation varies in cancers of over a hundred types, and their response to treatment can vary substantially. Several anti-cancer drugs have been discovered to treat various tumors, yet they still have harmful side-effects. Finding novel, highly efficient targeted therapies based on modifications in the molecular biology of tumor cells is essential to reduce the indiscriminate destruction of healthy cells. Exosomes, an extracellular vesicle, are promising as a drug carrier for cancer therapy due to their good tolerance in the body. In addition, the tumor microenvironment is a potential target to regulate in cancer treatment. Therefore, macrophages are polarized toward M1 and M2 phenotypes, which are involved in cancer proliferation and are malignant. It is evident from recent studies that controlled macrophage polarization might contribute to cancer treatment, by the direct way of using miRNA. This review provides an insight into the potential use of exosomes to develop an ‘indirect’, more natural, and harmless cancer treatment through regulating macrophage polarization.

  13. Effects of Particle Size of Curcumin Solid Dispersions on Bioavailability and Anti-Inflammatory Activities Peer-reviewed

    Chihiro Kato, Mayuko Itaya-Takahashi, Taiki Miyazawa, Junya Ito, Isabella Supardi Parida, Hiroki Yamada, Akari Abe, Mika Shibata, Keita Someya, Kiyotaka Nakagawa

    Antioxidants　12　(3)　724-724　2023/03/15

    Publisher: MDPI AG

    DOI： 10.3390/antiox12030724 　

    eISSN： 2076-3921

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    The delivery of curcumin (CUR) using the solid dispersion system (CUR solid dispersions; C-SDs) has been shown to improve CUR bioavailability. However, it is unclear how different particle sizes of C-SDs affect the bioavailability and biological activities of CUR. Hence, we prepared C-SDs in different sizes using food-grade excipients and evaluated their bioavailability and biological activities. By pulverizing large particle sizes of C-SDs using zirconia beads, we successfully prepared C-SDs I-IV (particle size: (I) 120, (II) 447, (III) 987, (IV) 1910 nm). When administrated orally in rats, the bioavailability of CUR was increased with decreasing C-SDs size, most likely by improving its solubility in micelles. When administrated intravenously in rats, blood concentrations of CUR were increased with increasing particle size, suggesting that larger C-SDs presumably control the metabolic conversion of CUR. In RAW264 cells, more CUR was taken up by cells as their sizes reduced, and the more potent their anti-inflammatory activities were, suggesting that smaller C-SDs were taken up through a number of cellular uptake pathways. Altogether, the present study showed an evident effect of C-SDs size on their bioavailability and anti-inflammatory activities—information that serves as a basis for improving the functionality of CUR.

  14. Microgreens—A Comprehensive Review of Bioactive Molecules and Health Benefits Peer-reviewed

    Maharshi Bhaswant, Dilip Kumar Shanmugam, Taiki Miyazawa, Chizumi Abe, Teruo Miyazawa

    Molecules　28　(2)　867-867　2023/01/15

    Publisher: MDPI AG

    DOI： 10.3390/molecules28020867 　

    eISSN： 1420-3049

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    Microgreens, a hypothesized term used for the emerging food product that is developed from various commercial food crops, such as vegetables, grains, and herbs, consist of developed cotyledons along with partially expanded true leaves. These immature plants are harvested between 7–21 days (depending on variety). They are treasured for their densely packed nutrients, concentrated flavors, immaculate and tender texture as well as for their vibrant colors. In recent years, microgreens are on demand from high-end restaurant chefs and nutritional researchers due to their potent flavors, appealing sensory qualities, functionality, abundance in vitamins, minerals, and other bioactive compounds, such as ascorbic acid, tocopherol, carotenoids, folate, tocotrienols, phylloquinones, anthocyanins, glucosinolates, etc. These qualities attracted research attention for use in the field of human health and nutrition. Increasing public concern regarding health has prompted humans to turn to microgreens which show potential in the prevention of malnutrition, inflammation, and other chronic ailments. This article focuses on the applications of microgreens in the prevention of the non-communicable diseases that prevails in the current generation, which emerged due to sedentary lifestyles, thus laying a theoretical foundation for the people creating awareness to switch to the recently introduced category of vegetable and providing great value for the development of health-promoting diets with microgreens.

  15. Biological functions of compounds from Bacillus subtilis and its subspecies, Bacillus subtilis natto Peer-reviewed

    Taiki Miyazawa, Chizumi Abe, Maharshi Bhaswant, Ryoichi Ikeda, Ohki Higuchi, Teruo Miyazawa

    Food Bioengineering　1　(3-4)　241-251　2022/12

    Publisher: Wiley

    DOI： 10.1002/fbe2.12036 　

    ISSN： 2770-2081

    eISSN： 2770-2081

  16. Characterization of Glycolipids in the Strain Chlorella pyrenoidosa Peer-reviewed

    Shinji YAMASHITA, Taiki MIYAZAWA, Ohki HIGUCHI, Hideo TAKEKOSHI, Teruo MIYAZAWA, Mikio KINOSHITA

    Journal of Nutritional Science and Vitaminology　68　(4)　353-357　2022/08/31

    Publisher: Center for Academic Publications Japan

    DOI： 10.3177/jnsv.68.353 　

    ISSN： 0301-4800

    eISSN： 1881-7742

  17. Current Use of Fenton Reaction in Drugs and Food Peer-reviewed

    Chizumi Abe, Taiki Miyazawa, Teruo Miyazawa

    Molecules　27　(17)　5451-5451　2022/08/25

    Publisher: MDPI AG

    DOI： 10.3390/molecules27175451 　

    eISSN： 1420-3049

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    Iron is the most abundant mineral in the human body and plays essential roles in sustaining life, such as the transport of oxygen to systemic organs. The Fenton reaction is the reaction between iron and hydrogen peroxide, generating hydroxyl radical, which is highly reactive and highly toxic to living cells. “Ferroptosis”, a programmed cell death in which the Fenton reaction is closely involved, has recently received much attention. Furthermore, various applications of the Fenton reaction have been reported in the medical and nutritional fields, such as cancer treatment or sterilization. Here, this review summarizes the recent growing interest in the usefulness of iron and its biological relevance through basic and practical information of the Fenton reaction and recent reports.

  18. Food Antioxidants and Aging: Theory, Current Evidence and Perspectives Peer-reviewed

    Taiki Miyazawa, Chizumi Abe, Gregor Carpentero Burdeos, Akira Matsumoto, Masako Toda

    Nutraceuticals　2　(3)　181-204　2022/08/03

    Publisher: MDPI AG

    DOI： 10.3390/nutraceuticals2030014 　

    eISSN： 1661-3821

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    The concept of food and aging is of great concern to humans. So far, more than 300 theories of aging have been suggested, and approaches based on these principles have been investigated. It has been reported that antioxidants in foods might play a role in human aging. To clarify the current recognition and positioning of the relationship between these food antioxidants and aging, this review is presented in the following order: (1) aging theories, (2) food and aging, and (3) individual food antioxidants and aging. Clarifying the significance of food antioxidants in the field of aging will lead to the development of strategies to achieve healthy human aging.

  19. Biological Functions of Antioxidant Dipeptides Peer-reviewed

    Hitoshi OZAWA, Taiki MIYAZAWA, Gregor Carpentero BURDEOS, Teruo MIYAZAWA

    Journal of Nutritional Science and Vitaminology　68　(3)　162-171　2022/06/30

    Publisher: Center for Academic Publications Japan

    DOI： 10.3177/jnsv.68.162 　

    ISSN： 0301-4800

    eISSN： 1881-7742

  20. Artificial intelligence in food science and nutrition: a narrative review Peer-reviewed

    Taiki Miyazawa, Yoichi Hiratsuka, Masako Toda, Nozomu Hatakeyama, Hitoshi Ozawa, Chizumi Abe, Ting-Yu Cheng, Yuji Matsushima, Yoshifumi Miyawaki, Kinya Ashida, Jun Iimura, Tomohiro Tsuda, Hiroto Bushita, Kazuichi Tomonobu, Satoshi Ohta, Hsuan Chung, Yusuke Omae, Takayuki Yamamoto, Makoto Morinaga, Hiroshi Ochi, Hajime Nakada, Kazuhiro Otsuka, Teruo Miyazawa

    Nutrition Reviews　2022/05/30

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/nutrit/nuac033 　

    ISSN： 0029-6643

    eISSN： 1753-4887

  21. Determination of intracellular ascorbic acid using tandem mass spectrometry Peer-reviewed

    Chizumi Abe, Ohki Higuchi, Akira Matsumoto, Taiki Miyazawa

    The Analyst　2022/05/18

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d1an02160e 　

    ISSN： 0003-2654

    eISSN： 1364-5528

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    Ascorbic acid is involved in a variety of biological events.

  22. Quantification of Bisacurone and Curcuminoids in Turmeric Products by Liquid Chromatography Coupled with Tandem Mass Spectrometry Peer-reviewed

    Taiki MIYAZAWA, Ohki HIGUCHI, Masato SASAKI, Minh Tu NGUYEN THI, Teruo MIYAZAWA

    Journal of Nutritional Science and Vitaminology　68　(2)　137-139　2022/04/30

    DOI： 10.3177/jnsv.68.137 　

    ISSN： 0301-4800

    eISSN： 1881-7742

  23. The inhibition of interaction with serum albumin enhances the physiological activity of curcumin by increasing its cellular uptake Peer-reviewed

    Mayuko Itaya, Taiki Miyazawa, Saoussane Khalifa, Naoki Shimizu, Kiyotaka Nakagawa

    Food & Function　13　(2)　639-648　2022/02/13

    DOI： 10.1039/d1fo03234h 　

    ISSN： 2042-6496

    eISSN： 2042-650X

  24. Effects of Dietary Food Components on Cognitive Functions in Older Adults Peer-reviewed

    Hitoshi Ozawa, Taiki Miyazawa, Teruo Miyazawa

    Nutrients　13　(8)　2804-2804　2021/08/16

    Publisher: {MDPI} {AG}

    DOI： 10.3390/nu13082804 　

  25. Removal of chlorophyll and pheophorbide from Chlorella pyrenoidosa by supercritical fluid extraction: potential of protein resource Peer-reviewed

    Taiki Miyazawa, Ohki Higuchi, Masato Sasaki, Masaki Ota, Tsutomu Aida, Hideo Takekoshi, Hiroshi Inomata, Teruo Miyazawa

    Bioscience, Biotechnology, and Biochemistry　85　(7)　1759-1762　2021/06/24

    Publisher: Informa UK Limited

    DOI： 10.1093/bbb/zbab095 　

    ISSN： 1347-6947 0916-8451

    eISSN： 1347-6947

  26. A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology Peer-reviewed

    Taiki Miyazawa, Mayuko Itaya, Gregor C Burdeos, Kiyotaka Nakagawa, Teruo Miyazawa

    International Journal of Nanomedicine　Volume 16　3937-3999　2021/06

    Publisher: Informa {UK} Limited

    DOI： 10.2147/IJN.S298606 　

  27. Boronic Acid Ligands Can Target Multiple Subpopulations of Pancreatic Cancer Stem Cells via pH-Dependent Glycan-Terminal Sialic Acid Recognition Peer-reviewed

    Miyazaki, Takuya, Khan, Thahomina, Tachihara, Yoshihiro, Itoh, Michiko, Miyazawa, Taiki, Suganami, Takayoshi, Miyahara, Yuji, Cabral, Horacio, Matsumoto, Akira

    ACS Applied Bio Materials　2021

    DOI： 10.1021/ACSABM.1C00383 　

    eISSN： 2576-6422

  28. Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system Peer-reviewed

    Akira Matsumoto, Hirohito Kuwata, Shinichiro Kimura, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-oka, Akiko Watanabe, Hironori Yamada, Hitoshi Ishii, Taiki Miyazawa, Siyuan Chen, Toshiaki Baba, Hiroshi Yoshida, Taichi Nakamura, Hiroshi Inoue, Yoshihiro Ogawa, Miyako Tanaka, Yuji Miyahara, Takayoshi Suganami

    Communications Biology　3　(1)　2020/12

    Publisher: Springer Science and Business Media {LLC}

    DOI： 10.1038/s42003-020-1026-x 　

  29. C-type lectin Mincle mediates cell death–triggered inflammation in acute kidney injury Peer-reviewed

    Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Yuki Sugiura, Tomofumi Miyamoto, Hiro Kohda, Ayaka Ito, Taiki Miyazawa, Akira Matsumoto, Seiichiro Aoe, Yoshihiro Miyamoto, Naotake Tsuboi, Shoichi Maruyama, Makoto Suematsu, Sho Yamasaki, Yoshihiro Ogawa, Takayoshi Suganami

    Journal of Experimental Medicine　217　(11)　2020/11/02

    Publisher: Rockefeller University Press

    DOI： 10.1084/jem.20192230 　

    ISSN： 0022-1007

    eISSN： 1540-9538

  30. Structural Control of Boronic Acid Ligands Enhances Intratumoral Targeting of Sialic Acid To Eradicate Cancer Stem-like Cells Peer-reviewed

    Thahomina Khan, Kazunori Igarashi, Ami Tanabe, Taiki Miyazawa, Shigeto Fukushima, Yutaka Miura, Yu Matsumoto, Tatsuya Yamasoba, Akira Matsumoto, Horacio Cabral, Kazunori Kataoka

    ACS Applied Bio Materials　3　(8)　5030-5039　2020/08/17

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acsabm.0c00530 　

    ISSN： 2576-6422

    eISSN： 2576-6422

  31. Vitamin E: Regulatory Redox Interactions Peer-reviewed

    Taiki Miyazawa, Gregor C. Burdeos, Mayuko Itaya, Kiyotaka Nakagawa, Teruo Miyazawa

    IUBMB Life　71　(4)　430-441　2019/04

    Publisher: Wiley

    DOI： 10.1002/iub.2008 　

    ISSN： 1521-6543

  32. The differential cellular uptake of curcuminoids in vitro depends dominantly on albumin interaction Peer-reviewed

    Itaya, M., Miyazawa, T., Zingg, J.-M., Eitsuka, T., Azzi, A., Meydani, M., Miyazawa, T., Nakagawa, K.

    Phytomedicine　59　2019

    DOI： 10.1016/j.phymed.2019.152902 　

    ISSN： 1618-095X 0944-7113

  33. Determination of cellular vitamin C dynamics by HPLC-DAD Peer-reviewed

    Taiki Miyazawa, Akira Matsumoto, Yuji Miyahara

    The Analyst　144　(11)　3483-3487　2019

    Publisher: Royal Society of Chemistry ({RSC})

    DOI： 10.1039/C8AN02240B 　

  34. Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β Peer-reviewed

    Taiki Miyazawa, Kiyotaka Nakagawa, Sharon H. Kim, Michael J. Thomas, Ligi Paul, Jean-Marc Zingg, Gregory G. Dolnikowski, Susan B. Roberts, Fumiko Kimura, Teruo Miyazawa, Angelo Azzi, Mohsen Meydani

    Nutrition & Metabolism　15　(1)　2018/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12986-018-0250-6 　

    ISSN： 1743-7075

    eISSN： 1743-7075

  35. Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes Peer-reviewed

    Miyazawa, T., Kamiyoshihara, R., Shimizu, N., Harigae, T., Otoki, Y., Ito, J., Kato, S., Miyazawa, T., Nakagawa, K.

    Royal Society Open Science　5　(2)　2018

    DOI： 10.1098/rsos.171249 　

    ISSN： 2054-5703

  36. Synthetic “smart gel” provides glucose-responsive insulin delivery in diabetic mice Peer-reviewed

    Akira Matsumoto, Miyako Tanaka, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-oka, Hirohito Kuwata, Hironori Yamada, Ibuki Shirakawa, Taiki Miyazawa, Hitoshi Ishii, Kazunori Kataoka, Yoshihiro Ogawa, Yuji Miyahara, Takayoshi Suganami

    Science Advances　3　(11)　2017/11/03

    Publisher: American Association for the Advancement of Science (AAAS)

    DOI： 10.1126/sciadv.aaq0723 　

    ISSN： 2375-2548

    eISSN： 2375-2548

  37. Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment Peer-reviewed

    A. Matsumoto, A. J. Stephenson-Brown, T. Khan, T. Miyazawa, H. Cabral, K. Kataoka, Y. Miyahara

    Chemical Science　8　(9)　6165-6170　2017

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/c7sc01905j 　

    ISSN： 2041-6520

    eISSN： 2041-6539

  38. Metabolic fate of poly-(lactic-co-glycolic acid)-based curcumin nanoparticles following oral administration Peer-reviewed

    Takahiro Harigae, Kiyotaka Nakagawa, Taiki Miyazawa, Nao Inoue, Fumiko Kimura, Ikuo Ikeda, Teruo Miyazawa

    International Journal of Nanomedicine　Volume 11　3009-3022　2016/06

    Publisher: Informa UK Limited

    DOI： 10.2147/ijn.s107442 　

    ISSN： 1178-2013 1176-9114

    eISSN： 1178-2013

  39. The combination of maternal and offspring high-fat diets causes marked oxidative stress and development of metabolic syndrome in mouse offspring Peer-reviewed

    Junya Ito, Kiyotaka Nakagawa, Shunji Kato, Taiki Miyazawa, Fumiko Kimura, Teruo Miyazawa

    Life Sciences　151　70-75　2016/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.lfs.2016.02.089 　

    ISSN： 0024-3205

  40. - Peer-reviewed

    Taiki MIYAZAWA, Takahiro HARIGAE, Kiyotaka NAKAGAWA

    KAGAKU TO SEIBUTSU　54　(7)　500-507　2016

    Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry

    DOI： 10.1271/kagakutoseibutsu.54.500 　

  41. Distribution of beta-carotene-encapsulated polysorbate 80-coated poly(D, L-lactide-co-glycolide) nanoparticles in rodent tissues following intravenous administration Peer-reviewed

    Taiki Miyazawa, Kiyotaka Nakagawa, Takahiro Harigae, Ryo Onuma, Fumiko Kimura, Tomoyuki Fujii, Teruo Miyazawa

    International Journal of Nanomedicine　7223-7223　2015/11

    Publisher: Informa UK Limited

    DOI： 10.2147/ijn.s94336 　

    ISSN： 1178-2013 1176-9114

    eISSN： 1178-2013

  42. Carbon tetrachloride-induced hepatic and renal damages in rat: inhibitory effects of cacao polyphenol Peer-reviewed

    Koichiro Suzuki, Kiyotaka Nakagawa, Takayuki Yamamoto, Taiki Miyazawa, Fumiko Kimura, Masanori Kamei, Teruo Miyazawa

    Bioscience, Biotechnology, and Biochemistry　79　(10)　1669-1675　2015/10/03

    Publisher: Informa UK Limited

    DOI： 10.1080/09168451.2015.1039481 　

    ISSN： 0916-8451

    eISSN： 1347-6947

  43. Young Persimmon Ingestion Suppresses Lipid Oxidation in Rats Peer-reviewed

    Saki FUSHIMI, Taiki MIYAZAWA, Fumiko KIMURA, Kiyotaka NAKAGAWA, Gregor Carpentero BURDEOS, Teruo MIYAZAWA

    Journal of Nutritional Science and Vitaminology　61　(1)　90-95　2015

    Publisher: Center for Academic Publications Japan

    DOI： 10.3177/jnsv.61.90 　

    ISSN： 0301-4800

    eISSN： 1881-7742

  44. Oxidative Stress during Development of Alcoholic Fatty Liver: Therapeutic Potential of Cacao Polyphenol Peer-reviewed

    Koichiro SUZUKI, Kiyotaka NAKAGAWA, Taiki MIYAZAWA, Shunji KATO, Fumiko KIMURA, Masanori KAMEI, Teruo MIYAZAWA

    Bioscience, Biotechnology, and Biochemistry　77　(8)　1792-1794　2013/08/23

    Publisher: Informa UK Limited

    DOI： 10.1271/bbb.130380 　

    ISSN： 0916-8451

    eISSN： 1347-6947

  45. Ingestion of Chlorella Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects Peer-reviewed

    Taiki Miyazawa, Kiyotaka Nakagawa, Hideo Takekoshi, Ohki Higuchi, Shunji Kato, Momoko Kondo, Fumiko Kimura, Teruo Miyazawa

    Journal of Oleo Science　62　(11)　873-881　2013

    Publisher: Japan Oil Chemists' Society

    DOI： 10.5650/jos.62.873 　

    ISSN： 1345-8957

    eISSN： 1347-3352

  46. Chlorella is an Effective Dietary Source of Lutein for Human Erythrocytes Peer-reviewed

    Taiki Miyazawa, Kiyotaka Nakagawa, Fumiko Kimura, Yuya Nakashima, Isao Maruyama, Ohki Higuchi, Teruo Miyazawa

    Journal of Oleo Science　62　(10)　773-779　2013

    Publisher: Japan Oil Chemists' Society

    DOI： 10.5650/jos.62.773 　

    ISSN： 1345-8957

    eISSN： 1347-3352

  47. Liquid chromatography-based assay for carotenoids in human blood Invited Peer-reviewed

    Miyazawa, T., Nakagawa, K., Miyazawa, T.

    Food and Nutritional Components in Focus　1　2012

    Publisher: Food and Nutritional Components in Focus

    ISSN： 2045-1695 2045-1709

  48. One-pot Synthesis of Manganese Oxide Nanoparticles from Microemulsion Systems Peer-reviewed

    Taiki Miyazawa, Keigo Matsuda, Atsuhiro Fujimori, Yoshimune Nonomura

    Chemistry Letters　40　(11)　1262-1263　2011/11/05

    DOI： 10.1246/cl.2011.1262 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  49. Amyloid β Induces Adhesion of Erythrocytes to Endothelial Cells and Affects Endothelial Viability and Functionality Peer-reviewed

    Kiyotaka NAKAGAWA, Takehiro KIKO, Satoko KURIWADA, Taiki MIYAZAWA, Fumiko KIMURA, Teruo MIYAZAWA

    Bioscience, Biotechnology, and Biochemistry　75　(10)　2030-2033　2011/10/23

    Publisher: Informa UK Limited

    DOI： 10.1271/bbb.110318 　

    ISSN： 0916-8451

    eISSN： 1347-6947

  50. Plasma Carotenoid Concentrations before and after Supplementation with Astaxanthin in Middle-Aged and Senior Subjects Peer-reviewed

    Taiki MIYAZAWA, Kiyotaka NAKAGAWA, Fumiko KIMURA, Akira SATOH, Teruo MIYAZAWA

    Bioscience, Biotechnology, and Biochemistry　75　(9)　1856-1858　2011/09/23

    Publisher: Informa UK Limited

    DOI： 10.1271/bbb.110368 　

    ISSN： 0916-8451

    eISSN： 1347-6947

  51. Erythrocytes Carotenoids after Astaxanthin Supplementation in Middle-Aged and Senior Japanese Subjects Peer-reviewed

    Taiki Miyazawa, Kiyotaka Nakagawa, Fumiko Kimura, Akira Satoh, Teruo Miyazawa

    Journal of Oleo Science　60　(10)　495-499　2011

    Publisher: Japan Oil Chemists' Society

    DOI： 10.5650/jos.60.495 　

    ISSN： 1345-8957

    eISSN： 1347-3352

  52. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes Peer-reviewed

    Nakagawa, K., Kiko, T., Miyazawa, T., Carpentero Burdeos, G., Kimura, F., Satoh, A., Miyazawa, T.

    British Journal of Nutrition　105　(11)　2011

    DOI： 10.1017/S0007114510005398 　

    ISSN： 0007-1145 1475-2662

  53. Amyloid β-induced erythrocytic damage and its attenuation by carotenoids Peer-reviewed

    Nakagawa, K., Kiko, T., Miyazawa, T., Sookwong, P., Tsuduki, T., Satoh, A., Miyazawa, T.

    FEBS Letters　585　(8)　2011

    DOI： 10.1016/j.febslet.2011.03.060 　

    ISSN： 0014-5793

  54. A challenge for preventing senile dementia with marine plasmalogen

    MIYAZAWA Teruo, MIYAZAWA Taiki, NAKAGAWA Kiyotaka

    Sessile Organisms　27　(2)　85-87　2010/08/31

    Publisher: THE SESSILE ORGANISMS SOCIETY OF JAPAN

    DOI： 10.4282/sosj.27.85 　

    ISSN： 1342-4181

  55. Tocotrienol distribution in foods: Estimation of daily tocotrienol Intake of Japanese Population Peer-reviewed

    Sookwong, P., Nakagawa, K., Yamaguchi, Y., Miyazawa, T., Kato, S., Kimura, F., Mlyazawa, T.

    Journal of Agricultural and Food Chemistry　58　(6)　2010

    DOI： 10.1021/jf903663k 　

    ISSN： 0021-8561 1520-5118

  56. LIPID PEROXIDATION IN HUMAN DISEASES AND ITS CONTROL WITH FOOD NUTRIENTS

    Miyazawa, Taiki, Kato, Shunji, Nakagawa, Kiyotaka, Miyazawa, Teruo

    Annals of Nutrition and Metabolism　2009

Show all ︎Show first 5

Misc. 5

  1. Attenuation of Inflammatory Markers in Plasma of Obese Mice by Caloric Restriction (CR) and Combined Curcumin (Cur) and Piperine (Pip) Supplementation

    Kiyotaka Nakagawa, Taiki Miyazawa, Sharon Kim, Michael Thomas, Fumiko Kimura, Teruo Miyazawa, Jean-Marc Zingg, Angelo Azzi, Mohsen Meydani

    FASEB JOURNAL　29　2015/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  2. Polysorbate-80 coated beta-carotene (encapsulated polymeric) nanoparticles accumulate in rat lungs after intravenous injection

    Taiki Miyazawa, Kiyotaka Nakagawa, Takahiro Harigae, Ryo Onuma, Fumiko Kimura, Tomoyuki Fujii, Teruo Miyazawa

    FASEB JOURNAL　29　2015/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  3. 認知症者における老化赤血球の出現と食品キサントフィルの効能

    宮澤 大樹, 喜古 健敬, 仲川 清隆, 荒井 啓行, 鈴木 俊英, 宮澤 陽夫

    ビタミン　85　(4)　235-235　2011/04

    Publisher: (公社)日本ビタミン学会

    ISSN： 0006-386X

  4. 認知症および血管新生病に対するビタミンEの改善効果 (特集 認知症と機能性食品)

    Phumon Sookwong, 宮澤 大樹, 仲川 清隆

    Functional food　3　(3)　253-258　2010

    Publisher: フジメディカル出版

    ISSN： 1882-3971

  5. アルツハイマー病に特徴的な赤血球膜脂質過酸化のアミロイドβによる誘発(Amyloid beta causes erythrocyte membrane lipid peroxidation as being characteristic in Alzheimer disease)

    宮澤 大樹, 喜古 健敬, 仲川 清隆, 荒井 啓行, 宮澤 陽夫

    日本生化学会大会プログラム・講演要旨集　82回　2T20a-3　2009/09

    Publisher: (公社)日本生化学会

Books and Other Publications 13

  1. Absorption, metabolism, and mechanisms of action of functional food compounds II

    Taiki Miyazawa

    2025/10

    ISBN: 9784781318738

  2. 栄養学レビュー

    宮澤大樹, 安部知純

    ILSI Japan（特定非営利活動法人 国際生命科学研究機構）　2023/08

    ISBN: 9784789561105

  3. 栄養学レビュー

    安部知純、宮澤大樹

    ILSI Japan（特定非営利活動法人 国際生命科学研究機構）　2022/08

    ISBN: 9784789561068

  4. 栄養学レビュー

    浅井明, 宮澤大樹

    ILSI Japan（特定非営利活動法人 国際生命科学研究機構）　2021/02

    ISBN: 9784789561006

  5. 機能性食品と薬理栄養

    板谷麻由子, 宮澤大樹, 仲川清隆

    日本医学中央会（メディカル・コア）　2020/04

  6. 2019年度アサヒグループ学術振興財団研究紀要

    仲川清隆, 宮澤大樹, 板谷麻由子

    2020

  7. 認知症と機能性食品 : 最新動向とその可能性

    宮澤大樹, 仲川清隆, 宮澤陽夫

    フジメディカル出版　2018/07

    ISBN: 9784862701695

  8. 食品機能性成分の吸収・代謝・作用機序

    宮澤大樹

    シーエムシー出版　2018/04

    ISBN: 9784781313276

  9. 食品機能性成分の吸収・代謝機構

    宮澤大樹

    シーエムシー出版　2013/05

    ISBN: 9784781307947

  10. Vitamin A and Carotenoids: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus)

    Preedy, Victor R., Royal Society of Chemistry (Great Britain)

    RSC Pub./Royal Society of Chemistry　2012/08/30

    ISBN: 1849733686

  11. FOOD STYLE 21

    2010/04

  12. Functional Food

    2010/02

  13. 機能性食品と薬理応用

    仲川清隆, 宮澤大樹, 喜古健敬, 宮澤陽夫

    2010

Show all Show first 5

Research Projects 5

  1. 食品・微生物成分による抗炎症型ミエロイド系細胞の分化と機能発現メカニズムの解析

    戸田 雅子, 高橋 恭子, 宮澤 大樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04 - 2025/03

    More details Close

    本研究では骨髄細胞から抗炎症型ミエロイド系細胞への分化を食品・微生物成分を用いて促進し、その抗炎症機能獲得メカニズムを明らかにすることを目的としている。ミエロイド系細胞は前駆細胞が血液を循環した後に組織へ定着し分化する樹状細胞や、マクロファージ、ミクログリアが含まれる。食品・微生物成分により前駆細胞の段階で抗炎症特性を獲得できれば、抗炎症特性を持つ細胞分化を促進でき、免疫制御へと結びけることができる。これまでに、マウス骨髄細胞の培養系を用いて、n-3系多価不飽和脂肪酸の一種、エイコサペンタエン酸がミエロイド系マクロファージの分化を促進し、その機序として核内受容体 peroxisome proliferator activated receptor γ(PPARγ)との結合が関与することを明らかにしている。また、酵母（Saccharomyces cerevisiae）由来αマンナンがミエロイド系細胞の抗炎症機能獲得を促進すること、その機序にはSpleen tyrosine kinase（Syk）やPhosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)経路が関与することを見いだしている。本研究はミエロイド系細胞の機能獲得メカニズムに新たな知見をもたらし、科学的根拠に基づく免疫機能性食品の開発に貢献すると期待される。

  2. Clarifying the biological role of vitaminC metabolites

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    2018/04 - 2022/03

  3. -

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows

    Category: Grant-in-Aid for JSPS Fellows

    Institution: Tokyo Medical and Dental University

    2017/04 - 2020/03

  4. - Competitive

    Taiki Miyazawa

    Offer Organization: Japan Society for the Promotion of Science

    System: Japan Society for the Promotion of Science (JSPS) Post Doctoral Research Fellow for Research Abroad

    2014 - 2015

  5. -

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows

    Category: Grant-in-Aid for JSPS Fellows

    Institution: Tohoku University

    2012 - 2013

Other 1

  1. 第29回浜松医科大学メディカルフォトニクス・コース

    More details Close

    修了