Details of the Researcher

PHOTO

Makoto Arai
Section
Graduate School of Medicine
Job title
Senior Assistant Professor
Degree

  • (The University of Tokyo)

Research History 7

  • 2026/02 - Present
    Tohoku University　Graduate School of Medicine, Division of Molecular Physiology and Metabolism

  • 2023/04 - 2026/01
    Tohoku University　Graduate School of Medicine, Division of Molecular Physiology and Metabolism

  • 2022/04 - 2023/03
    The University of Tokyo　Research Center for Advanced Science and Technology

  • 2019/04 - 2022/03
    JSPS　Research Fellow PD

  • 2019/04 - 2022/03
    Tohoku University　Graduate School of Medicine　Division of Molecular Physiology and Metabolism

  • 2013/04 - 2015/03
    Toranomon Hospital

  • 2011/04 - 2013/03
    Asahi General Hospital

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Education 2

  • The University of Tokyo　Graduate School of Medicine

    2015/04 - 2019/03

  • The University of Tokyo　Faculty of Medicine

    2005/04 - 2011/03

Research Areas 2

  • Life sciences / Orthopedics /

  • Life sciences / Metabolism and endocrinology /

Awards 6

  1. 東北医学会奨学賞・奨学賞A

    2026/01　東北医学会

  2. ASBMR 2021 Travel Award

    2021/10　日本骨代謝学会

  3. ECTS 2021 EAST MEETS WEST Award

    2021/05　ヨーロッパ石灰化組織学会

  4. 若手研究奨励賞（Young Investigator Award）

    2021/04　日本内分泌学会

  5. Young Investigator Travel Grant

    2019/09　アメリカ骨代謝学会

  6. ASBMR 2019 Travel Award

    2019/09　日本骨代謝学会

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Research Projects 4

  1. Epigenetic regulation in steroid-induced osteoporosis

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2024/04/01 - 2027/03/31

  2. Regulation of bone formation by histone demethylase

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: The University of Tokyo

    2022/04 - 2024/03

  3. Functional shift in neural circuits to prevent lifestyle diseases

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows

    Category: Grant-in-Aid for JSPS Fellows

    Institution: Tohoku University

    2019/04/25 - 2022/03/31

  4. Novel strategies for the treatment of Cushing disease using machine learning techniques targeting intermediate filaments

    Arai Makoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2020/04 - 2022/03

    More details Close

    Cushing disease is caused by ACTH-producing pituitary adenomas, leading to hypercortisolemia and its related comorbidities such as hypertension, diabetes, infection and osteoporosis. It is often difficult to cure Cushing disease solely by surgical resections or radiation therapies, but the effects of medications against Cushing disease are also limited. Here I aimed to search for therapeutic targets of Cushing disease from pathological perspectives. The analyses of the resected adenomas revealed the staining of cytokeratin showed distinguished patterns in some cases which were different from typical adenomas or known subtypes.