-
Kornblum-Type Oxidative Ring-Opening Reaction of a Tricyclo[4.3.0.05,7]nonane Derivative for the Synthesis of a CD Ring System of Steroids
Hiroki Yamauchi, Hiroyuki Yamakoshi, Manato Uchida, Mai Ishikawa, Eisaku Ohashi, Seiichi Nakamura
Synlett 2026/08/04
DOI：
10.1055/a-2920-5526
-
Total Synthesis of JBIR-141 and Its Analogues: Potent Inhibitors of Forkhead Box O3 (FOXO3)
Hidetoshi Ban, Kotaro Yasoshima, Kosuke Ohsawa, Madoka Suzuki, Noritaka Kagaya, Teppei Kawahara, Hiroyuki Yamakoshi, Masahito Yoshida, Kazuo Shin-ya, Takayuki Doi
Organic Letters 2026/07/31
DOI：
10.1021/acs.orglett.6c02149
-
Nrf2 activation by the monocarbonyl curcumin derivative GO-Y015 confers cellular protection against arsenite toxicity by reducing intracellular arsenic levels
Md. Tanvir Islam, Hiroki Taguchi, Hiroyuki Yamakoshi, Wang Yinuo, Hiroyuki Shibata, Yoshiharu Iwabuchi, Takashi Toyama, Yoshiro Saito
Scientific Reports 2026/04/18
Publisher:
Springer Science and Business Media LLC
DOI：
10.1038/s41598-026-49334-0
eISSN：
2045-2322
-
Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 Degraders
Hiroyuki Yamakoshi, Ryo Watanabe, Ryosuke Segawa, Ryosuke Ishihara, Ryo Tachibana, Genki Kudo, Shota Nagasawa, Satoshi Yamanaka, Ayano Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Ryunosuke Yoshino, Takatsugu Hirokawa, Takayuki Doi, Noriyasu Hirasawa, Yoshiharu Iwabuchi
Journal of Medicinal Chemistry 2026/04/09
DOI：
10.1021/acs.jmedchem.5c03771
-
Oxidative Generation of Isobenzofurans for Intermolecular Cycloadditions
Emi Nakatsugawa, Keigetsu Higashiyama, Hiroyuki Yamakoshi, Eisaku Ohashi, Seiichi Nakamura
The Journal of Organic Chemistry 2025/11/28
DOI：
10.1021/acs.joc.5c02245
-
Visualizing Thiol Stress Responses in Cells with a Water-Soluble Raman Sensor
Hiroyuki Yamakoshi, Meichen Wang, Keisuke Koga, Shinji Kajimoto, Yuse Kuriyama, Yusuke Sasano, Takaaki Akaike, Yoshiharu Iwabuchi, Takakazu Nakabayashi
Analytical Chemistry 2025/11/25
DOI：
10.1021/acs.analchem.5c04391
-
In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID
Kohdai Yamada, Satoshi Yamanaka, Hiroyuki Yamakoshi, Aki Kohyama, Yoshiharu Iwabuchi, Hidetaka Kosako, Tatsuya Sawasaki
Communications Biology 2025/08/30
DOI：
10.1038/s42003-025-08761-x
-
Alkyne-tag Raman imaging and sensing of bioactive compounds
Kosuke Dodo, William J. Tipping, Hiroyuki Yamakoshi, Syusuke Egoshi, Toshiki Kubo, Yasuaki Kumamoto, Karen Faulds, Duncan Graham, Katsumasa Fujita, Mikiko Sodeoka
Nature Reviews Methods Primers 2025/03/27
DOI：
10.1038/s43586-025-00389-9
-
Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction
Hiroyuki Yamakoshi, Michihiro Fukuda, Hiro Ikeda, Shogo Fujiki, Aki Kohyama, Shota Nagasawa, Hanae Shinozaki, Hiroyuki Shibata, Yoshiharu Iwabuchi
Chemical and Pharmaceutical Bulletin 72 (1) 127-134 2024/01/30
Publisher:
Pharmaceutical Society of Japan
DOI：
10.1248/cpb.c23-00775
ISSN：
0009-2363
eISSN：
1347-5223
-
Development of a fluorous trapping reagent for rapid detection of electrophilic reactive metabolites
Yusuke Akagi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi
Analytical Methods 16 (24) 3810-3814 2024
Publisher:
Royal Society of Chemistry (RSC)
DOI：
10.1039/d4ay00577e
ISSN：
1759-9660
eISSN：
1759-9679
-
New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line
Kota Sato, Yuto Sasaki, Michiko Ohno-Oishi, Kuniyuki Kano, Junken Aoki, Kosuke Ohsawa, Takayuki Doi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Chihiro Kawano, Yoshiyuki Hirata, Toru Nakazawa
The Tohoku Journal of Experimental Medicine 263 (2) 151-160 2024
Publisher:
Tohoku University Medical Press
DOI：
10.1620/tjem.2024.j024
ISSN：
0040-8727
eISSN：
1349-3329
-
Oxidative generation of isobenzofurans from phthalans: application to the formal synthesis of (±)-morphine
Mirai Kage, Hiroyuki Yamakoshi, Manami Tabata, Eisaku Ohashi, Kimihiro Noguchi, Takeshi Watanabe, Manato Uchida, Minetatsu Takada, Kazutada Ikeuchi, Seiichi Nakamura
Chemical Science 15 (45) 19070-19076 2024
Publisher:
Royal Society of Chemistry (RSC)
DOI：
10.1039/d4sc05890a
ISSN：
2041-6520
eISSN：
2041-6539
-
Mono-Carbonyl Curcumin Analogs for Cancer Therapy
Takashi MaruYama, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata
Biological and Pharmaceutical Bulletin 46 (6) 756-763 2023/06/01
Publisher:
Pharmaceutical Society of Japan
DOI：
10.1248/bpb.b23-00103
ISSN：
0918-6158
eISSN：
1347-5215
-
A Nitrile-Tagged Raman Sensor for the Ratiometric Detection of Thiols in Live Cells
Hiroyuki Yamakoshi, Daiki Shibata, Kazuki Bando, Shinji Kajimoto, Aki Kohyama, Syusuke Egoshi, Kosuke Dodo, Yoshiharu Iwabuchi, Mikiko Sodeoka, Katsumasa Fujita, Takakazu Nakabayashi
2023/05/15
DOI：
10.26434/chemrxiv-2023-0lkm0
-
Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q
Peer-reviewed
Shogo Moriyama, Miyu Mae, Daiki Shibata, Hiroyuki Yamakoshi, Shinji Kajimoto, Takakazu Nakabayashi, Takayoshi Ishimoto, Kaiki Mogi, Hironao Sajiki, Shuji Akai, Yoshinari Sawama
Chemical Communications 59 12100-12103 2023
Publisher:
Royal Society of Chemistry (RSC)
DOI：
10.1039/d3cc04410f
ISSN：
1359-7345
eISSN：
1364-548X
-
Raman Imaging and Screening of Bioactive Small Molecules
Hiroyuki Yamakoshi, Jun Ando, Syusuke Egoshi, Kosuke Dodo, Mikiko Sodeoka, Katsumasa Fujita
Raman Spectroscopy in Human Health and Biomedicine 271-298 2023/01/01
DOI：
10.1142/9789811264610_0008
-
Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy
Hiroyuki Yamakoshi, Daiki Shibata, Kazuki Bando, Shinji Kajimoto, Aki Kohyama, Syusuke Egoshi, Kosuke Dodo, Yoshiharu Iwabuchi, Mikiko Sodeoka, Katsumasa Fujita, Takakazu Nakabayashi
Chemical Communications 2023
Publisher:
Royal Society of Chemistry (RSC)
DOI：
10.1039/d3cc05015g
ISSN：
1359-7345
eISSN：
1364-548X
-
LiHMDS‐mediated deprotonative coupling of toluenes with ketones
Masanori Shigeno, Akihisa Kajima, Eito Toyama, Toshinobu Korenaga, Hiroyuki Yamakoshi, Kanako Nozawa-Kumada, Yoshinori Kondo
Chemistry – A European Journal 29 (15) 2022/12/07
Publisher:
Wiley
DOI：
10.1002/chem.202203549
ISSN：
0947-6539
eISSN：
1521-3765
-
Stereoselective Synthesis of the DE Ring Portion of Kadcoccilactone A by a Radical Addition/Cyclization Approach
Kimihiro Noguchi, Sayuri Saito, Hiroyuki Yamakoshi, Seiichi Nakamura
European Journal of Organic Chemistry 2022 (45) 2022/12/06
Publisher:
Wiley
DOI：
10.1002/ejoc.202201201
ISSN：
1434-193X
eISSN：
1099-0690
-
Direct C–H Carboxylation Forming Polyfunctionalized Aromatic Carboxylic Acids by Combined Brønsted Bases
Masanori Shigeno, Kazuya Hanasaka, Itsuki Tohara, Koki Izumi, Hiroyuki Yamakoshi, Eunsang Kwon, Kanako Nozawa-Kumada, Yoshinori Kondo
Organic Letters 24 (3) 809-814 2022/01/28
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/acs.orglett.1c03866
ISSN：
1523-7060
eISSN：
1523-7052
-
Stereoselective 1,4-Addition of Primary Alcohols to γ-Alkoxy-α,β-unsaturated Esters
Saki Inatomi, Yuta Takayanagi, Kento Watanabe, Akinori Toita, Hiroyuki Yamakoshi, Seiichi Nakamura
Synthesis (Germany) 53 (1) 161-174 2021/01/05
DOI：
10.1055/s-0040-1707274
ISSN：
0039-7881
eISSN：
1437-210X
-
Studies on the syntheses of bioactive natural products having a fused ring system based on novel skeletal construction methods,新規骨格構築法を基盤とする縮環生物活性天然物の合成研究
Yamakoshi, H.
Yakugaku Zasshi 141 (9) 2021
DOI：
10.1248/yakushi.21-00126
ISSN：
1347-5231 0031-6903
-
Spontaneous Raman and SERS microscopy for Raman tag imaging
Yamakoshi, H., Fujita, K.
Stimulated Raman Scattering Microscopy: Techniques and Applications 2021
DOI：
10.1016/B978-0-323-85158-9.00028-2
-
Quantitative drug dynamics visualized by alkyne-tagged plasmonic-enhanced Raman microscopy
Kota Koike, Kazuki Bando, Jun Ando, Hiroyuki Yamakoshi, Naoki Terayama, Kosuke Dodo, Nicholas Isaac Smith, Mikiko Sodeoka, Katsumasa Fujita
ACS Nano 14 (11) 15032-15041 2020/11/24
DOI：
10.1021/acsnano.0c05010
ISSN：
1936-0851
eISSN：
1936-086X
-
Total Syntheses of Marrubiin and Related Labdane Diterpene Lactones
Yukari Sakagami, Naoki Kondo, Yuki Sawayama, Hiroyuki Yamakoshi, Seiichi Nakamura
Molecules 25 (7) 1610-1610 2020/04/01
Publisher:
MDPI AG
DOI：
10.3390/molecules25071610
ISSN：
1420-3049
eISSN：
1420-3049
-
Second-generation synthesis of a chiral building block for oxygenated terpenoids via a ring-contractive coupling with a secondary alcohol
Peer-reviewed
S. Saito, H. Yamakoshi, S. Nakamura
Heterocycles 99 (2) 1086-1094 2019/01
Publisher:
Japan Institute of Heterocyclic Chemistry
DOI：
10.3987/com-18-s(f)74
ISSN：
0385-5414
-
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
Peer-reviewed
Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo
NATURE COMMUNICATIONS 9 (1) 2018/07
DOI：
10.1038/s41467-018-05127-2
ISSN：
2041-1723
-
Tandem oxidation/cyclization reaction of 4-(arylmethyl)oxy-2-diazobutyrate derivatives
Peer-reviewed
H. Kondo, S. Nagano, H. Yamakoshi, S. Nakamura
Heterocycles 97 (2) 894-894 2018
Publisher:
Japan Institute of Heterocyclic Chemistry
DOI：
10.3987/com-18-s(t)67
ISSN：
0385-5414
-
The alkyne-tag Raman imaging of coronatine, a plant pathogen virulence factor, in: Commelina communis and its possible mode of action
Peer-reviewed
Minoru Ueda, Kengo Hayashi, Syusuke Egoshi, Yasuhiro Ishimaru, Yousuke Takaoka, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka
Organic and Biomolecular Chemistry 16 (18) 3348-3352 2018
Publisher:
Royal Society of Chemistry
DOI：
10.1039/c8ob00097b
ISSN：
1477-0520
-
Cyclization of alpha-Diazo Esters Triggered by Oxidation: A Facile Preparation of 5-Aryl-2,3-dihydrofuran-4-carboxylates
Peer-reviewed
Hideaki Kondo, Hiroyuki Yamakoshi, Ayaka Kimura, Seiichi Nakamura
CHEMISTRYSELECT 2 (20) 5646-5649 2017/07
DOI：
10.1002/slct.201701090
ISSN：
2365-6549
-
Noncanonical Function of a Small-Molecular Virulence Factor Coronatine against Plant Immunity: An In Vivo Raman Imaging Approach
Minoru Ueda, Syusuke Egoshi, Kosuke Dodo, Yasuhiro Ishimaru, Hiroyuki Yamakoshi, Takeshi Nakano, Yousuke Takaoka, Shinya Tsukiji, Mikiko Sodeoka
ACS CENTRAL SCIENCE 3 (5) 462-472 2017/05
DOI：
10.1021/acscentsci.7b00099
ISSN：
2374-7943
eISSN：
2374-7951
-
Surface-enhanced Raman scattering (SERS) imaging of alkyne-tagged small molecule drug in live cells with endocytosed gold nanoparticles
Peer-reviewed
Jun Ando, Takumasa Sekiya, Den Ka, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka, Satoshi Kawata, Katsumasa Fujita
VISUALIZING AND QUANTIFYING DRUG DISTRIBUTION IN TISSUE 10046 2017
DOI：
10.1117/12.2256126
ISSN：
0277-786X
-
A DOUBLE HEMIKETAL FORMATION/HETERO-MICHAEL ADDITION APPROACH TO THE [6,5,5]-DISPIROKETAL SYSTEM OF SPIROLIDES
Hiroyuki Yamakoshi, Akinori Toita, Toshihiro Igari, Keisuke Takeda, Shunichi Hashimoto, Seiichi Nakamura
HETEROCYCLES 95 (2) 934-949 2017/01
DOI：
10.3987/COM-16-S(S)61
ISSN：
0385-5414
eISSN：
1881-0942
-
Alkyne-Tag SERS Screening and Identification of Small-Molecule-Binding Sites in Protein
Jun Ando, Miwako Asanuma, Kosuke Dodo, Hiroyuki Yamakoshi, Satoshi Kawata, Katsumasa Fujita, Mikiko Sodeoka
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 138 (42) 13901-13910 2016/10
DOI：
10.1021/jacs.6b06003
ISSN：
0002-7863
-
Total Syntheses of (+)-Marrubiin and (-)-Marrulibacetal
Hiroyuki Yamakoshi, Yuki Sawayama, Yoshihiro Akahori, Marie Kato, Seiichi Nakamura
ORGANIC LETTERS 18 (14) 3430-3433 2016/07
DOI：
10.1021/acs.orglett.6b01602
ISSN：
1523-7060
eISSN：
1523-7052
-
A Curcumin Analog, GO-Y078, Effectively Inhibits Angiogenesis through Actin Disorganization
Shunsuke Sugiyama, Yuki Yoshino, Sei Kuriyama, Masahiro Inoue, Keigo Komine, Kazunori Otsuka, Aki Kohyama, Hiroyuki Yamakoshi, Chikashi Ishioka, Masamitsu Tanaka, Yoshiharu Iwabuchi, Hiroyuki Shibata
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 16 (5) 633-647 2016
DOI：
10.2174/1871520615666151013125559
ISSN：
1871-5206
eISSN：
1875-5992
-
Dual function of coronatine as a bacterial virulence factor against plants: possible COI1-JAZ-independent role
Syusuke Egoshi, Yousuke Takaoka, Hiroaki Saito, Yuuki Nukadzuka, Kengo Hayashi, Yasuhiro Ishimaru, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka, Minoru Ueda
RSC ADVANCES 6 (23) 19404-19412 2016
DOI：
10.1039/c5ra20676f
ISSN：
2046-2069
-
A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa
Koji Fukuda, Yoshihiko Uehara, Eiko Nakata, Masahiro Inoue, Kazuhiro Shimazu, Taichi Yoshida, Hiroaki Kanda, Hiroshi Nanjo, Yoshio Hosoi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 92 (7) 388-394 2016
DOI：
10.3109/09553002.2016.1164910
ISSN：
0955-3002
eISSN：
1362-3095
-
Reversibility of the thia-Michael reaction of cytotoxic C-5-curcuminoid and structure-activity relationship of bis-thiol-adducts thereof
Aki Kohyama, Michihiro Fukuda, Shunsuke Sugiyama, Hiroyuki Yamakoshi, Naoki Kanoh, Chikashi Ishioka, Hiroyuki Shibatac, Yoshiharu Iwabuchi
ORGANIC & BIOMOLECULAR CHEMISTRY 14 (45) 10683-10687 2016
DOI：
10.1039/c6ob01771a
ISSN：
1477-0520
eISSN：
1477-0539
-
Construction of Bridged Polycyclic Systems by Polyene Cyclization
Keisuke Suzuki, Hiroyuki Yamakoshi, Seiichi Nakamura
CHEMISTRY-A EUROPEAN JOURNAL 21 (49) 17605-17609 2015/12
DOI：
10.1002/chem.201503969
ISSN：
0947-6539
eISSN：
1521-3765
-
Inhibition of beta-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo
Yoshihiko Uehara, Masahiro Inoue, Koji Fukuda, Hiroyuki Yamakoshi, Yoshio Hosoi, Hiroaki Kanda, Masanobu Oshima, Yoshiharu Iwabuchi, Hiroyuki Shibata
GASTRIC CANCER 18 (4) 774-783 2015/10
DOI：
10.1007/s10120-014-0434-3
ISSN：
1436-3291
eISSN：
1436-3305
-
Structure-Activity Relationships of the Antitumor C-5-Curcuminoid GO-Y030
Aki Kohyama, Hiroyuki Yamakoshi, Shoko Hongo, Naoki Kanoh, Hiroyuki Shibata, Yoshiharu Iwabuchi
MOLECULES 20 (8) 15374-15391 2015/08
DOI：
10.3390/molecules200815374
ISSN：
1420-3049
-
Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior
Jin Cui, Shigeru Matsuoka, Masanao Kinoshita, Nobuaki Matsumori, Fuminori Sato, Michio Murata, Jun Ando, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka
BIOORGANIC & MEDICINAL CHEMISTRY 23 (13) 2989-2994 2015/07
DOI：
10.1016/j.bmc.2015.05.014
ISSN：
0968-0896
eISSN：
1464-3391
-
Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy
Jun Ando, Masanao Kinoshita, Jin Cui, Hiroyuki Yamakoshi, Kosuke Dodo, Katsumasa Fujita, Michio Murata, Mikiko Sodeoka
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112 (15) 4558-4563 2015/04
DOI：
10.1073/pnas.1418088112
ISSN：
0027-8424
-
A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria
Hiroyuki Yamakoshi, Almar Palonpon, Kosuke Dodo, Jun Ando, Satoshi Kawata, Katsumasa Fujita, Mikiko Sodeoka
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25 (3) 664-667 2015/02
DOI：
10.1016/j.bmcl.2014.11.080
ISSN：
0960-894X
eISSN：
1464-3405
-
Visualization of lipid rafts in an artificial monolayer membrane by using slit-scanning Raman microscopy
Jun Ando, Masanao Kinoshita, Jin Cui, Hiroyuki Yamakoshi, Kosuke Dodo, Katsumasa Fujita, Michio Murata, Mikiko Sodeoka
Optics InfoBase Conference Papers 2019 2015
Publisher:
OSA - The Optical Society
-
Alkyne-tag Raman imaging of bio-active small molecules in live cells
Peer-reviewed
Jun Ando, Almar F. Palonpon, Hiroyuki Yamakoshi, Kosuke Dodo, Satoshi Kawata, Mikiko Sodeoka, Katsumasa Fujita
Progress in Biomedical Optics and Imaging - Proceedings of SPIE 9792 2015
Publisher:
SPIE
DOI：
10.1117/12.2207554
ISSN：
1605-7422
-
Raman Spectroscopic Detection of Bio-Active Small Molecules using Alkyne Tag
Peer-reviewed
Jun Ando, Almar Palonpon, Satoshi Kawata, Katsumasa Fujita, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka
IEEE CPMT SYMPOSIUM JAPAN 2015, (ICSJ 2015) 93-96 2015
DOI：
10.1109/ICSJ.2015.7357369
ISSN：
2373-5449
-
Alkyne-tag Raman imaging of bio-active small molecules in live cells
Peer-reviewed
Ando Jun, Palonpon Almar F, Yamakoshi Hiroyuki, Dodo Kosuke, Kawata Satoshi, Sodeoka Mikiko, Fujita Katsumasa
BIOPHOTONICS JAPAN 2015 9792 2015
DOI：
10.1117/12.2207554
ISSN：
0277-786X
-
Strong inhibitory effects of curcumin and its demethoxy analog on Escherichia coli ATP synthase F-1 sector
Mizuki Sekiya, Eiko Chiba, Momoe Satoh, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Masamitsu Futai, Mayumi Nakanishi-Matsui
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 70 241-245 2014/09
DOI：
10.1016/j.ijbiomac.2014.06.055
ISSN：
0141-8130
eISSN：
1879-0003
-
Stereoselective Synthesis of the CDE Ring System of Antitumor Saponin Scillascilloside E-1
Yoshihiro Akahori, Hiroyuki Yamakoshi, Shunichi Hashimoto, Seiichi Nakamura
ORGANIC LETTERS 16 (7) 2054-2057 2014/04
DOI：
10.1021/ol500657f
ISSN：
1523-7060
eISSN：
1523-7052
-
In vivo Raman Imaging of living guard cells for elucidating the site of action of the plant toxin coronatine.
Egoshi Syusuke, Yamakoshi Hiroyuki, Dodo Kousuke, Iwashita Toshiki, Ishimaru Yasuhiro, Sodeoka Mikiko, Ueda Minoru
Symposium on the Chemistry of Natural Products, symposium papers 56 Oral14 2014
Publisher:
Symposium on the Chemistry of Natural Products Steering Committee
DOI：
10.24496/tennenyuki.56.0_Oral14
-
Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy
Hiroyuki Yamakoshi, Almar F. Palonpon, Kosuke Dodo, Jun Ando, Satoshi Kawata, Katsumasa Fujita, Mikiko Sodeoka
CHEMICAL COMMUNICATIONS 50 (11) 1341-1343 2014
DOI：
10.1039/c3cc48587k
ISSN：
1359-7345
eISSN：
1364-548X
-
Synthesis of Chiral Building Blocks for Oxygenated Terpenoids through a Simultaneous and Stereocontrolled Construction of Contiguous Quaternary Stereocenters by an Ireland-Claisen Rearrangement
Yoshihiro Akahori, Hiroyuki Yamakoshi, Yuki Sawayama, Shunichi Hashimoto, Seiichi Nakamura
JOURNAL OF ORGANIC CHEMISTRY 79 (2) 720-735 2014/01
DOI：
10.1021/jo402537u
ISSN：
0022-3263
-
Raman and SERS microscopy for molecular imaging of live cells
Almar F. Palonpon, Jun Ando, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka, Satoshi Kawata, Katsumasa Fujita
NATURE PROTOCOLS 8 (4) 677-692 2013/04
DOI：
10.1038/nprot.2013.030
ISSN：
1754-2189
-
Watching bioactive small molecules in live cells by alkyne-tag Raman imaging
Almar Palonpon, Hiroyuki Yamakoshi, Kosuke Dodo, Jun Ando, Satoshi Kawata, Katsumasa Fujita, Mikiko Sodeoka
Optics InfoBase Conference Papers 2013
Publisher:
Optical Society of America (OSA)
DOI：
10.1364/jsap.2013.19p_d4_5
ISSN：
2162-2701
-
Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells
Hiroyuki Yamakoshi, Kosuke Dodo, Almar Palonpon, Jun Ando, Katsumasa Fujita, Satoshi Kawata, Mikiko Sodeoka
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134 (51) 20681-20689 2012/12
DOI：
10.1021/ja308529n
ISSN：
0002-7863
-
Raman imaging of alkyne as a small tag for biological molecules
Peer-reviewed
Katsumasa Fujita, Hiroyuki Yamakoshi, Kosuke Dodo, Almar Palonpon, Masaya Okada, Jun Ando, Satoshi Kawata, Mikiko Sodeoka
Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8225 2012
DOI：
10.1117/12.907984
ISSN：
1605-7422
-
Raman imaging of alkyne as a small tag for biological molecules
Peer-reviewed
Fujita Katsumasa, Yamakoshi Hiroyuki, Dodo Kosuke, Palonpon Almar, Okada Masaya, Ando Jun, Kawata Satoshi, Sodeoka Mikiko
IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES X 8225 2012
DOI：
10.1117/12.907984
ISSN：
0277-786X
-
Novel Curcumin Analogs, GO-Y030 and GO-Y078, Are Multitargeted Agents with Enhanced Abilities for Multiple Myeloma
Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata
ANTICANCER RESEARCH 31 (11) 3719-3726 2011/11
ISSN：
0250-7005
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High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound
Daisuke Saigusa, Masatoshi Shibuya, Daisuke Jinno, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Akihito Yokosuka, Yoshihiro Mimaki, Akira Naganuma, Yasushi Ohizumi, Yoshihisa Tomioka, Tohru Yamakuni
ANALYTICAL AND BIOANALYTICAL CHEMISTRY 400 (10) 3635-3641 2011/07
DOI：
10.1007/s00216-011-5031-2
ISSN：
1618-2642
eISSN：
1618-2650
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Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo
Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hiroshi Nanjo, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata
BMC Pharmacology 11 2011/05/28
DOI：
10.1186/1471-2210-11-4
ISSN：
1471-2210
-
Curcumin analog GO-Y030 is a novel inhibitor of IKK beta that suppresses NF-kappa B signaling and induces apoptosis
Atsuko Sato, Chieko Kudo, Hiroyuki Yamakoshi, Yoshihiko Uehara, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata
CANCER SCIENCE 102 (5) 1045-1051 2011/05
DOI：
10.1111/j.1349-7006.2011.01886.x
ISSN：
1347-9032
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Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy
Hiroyuki Yamakoshi, Kosuke Dodo, Masaya Okada, Jun Ando, Almar Palonpon, Katsumasa Fujita, Satoshi Kawata, Mikiko Sodeoka
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133 (16) 6102-6105 2011/04
DOI：
10.1021/ja108404p
ISSN：
0002-7863
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HPLC/PDA法を用いた体内動態解析による抗アルツハイマー病天然薬物ノビレチンの脳内移行の証明
三枝 大輔, 中島 晶, 鐵 尚美, 澁谷 正俊, 山越 博幸, 岩渕 好治, 横須賀 章人, 指田 豊, 三巻 祥浩, 永沼 章, 大泉 康, 富岡 佳久
日本薬学会年会要旨集 131年会 (4) 139-139 2011/03
Publisher:
(公社)日本薬学会
ISSN：
0918-9823
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Slit-scanning confocal Raman microscopy: Practical applications in live cell imaging
Peer-reviewed
Almar Palonpon, Masaya Okada, Jun Ando, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka, Satoshi Kawata, Katsumasa Fujita
2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf. 86-88 2011
DOI：
10.1109/IQEC-CLEO.2011.6193906
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Construction of Fluorinated Chiral Center
YAMAKOSHI Hiroyuki
J. Synth. Org. Chem. Jpn. 68 (9) 962-963 2010/09/01
Publisher:
The Society of Synthetic Organic Chemistry, Japan
DOI：
10.5059/yukigoseikyokaishi.68.962
ISSN：
0037-9980
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KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue
Hiroyuki Yamakoshi, Naoki Kanoh, Chieko Kudo, Atsuko Sato, Kazunori Ueda, Makoto Muroi, Shunsuke Kon, Masanobu Satake, Hisatsugu Ohori, Chikashi Ishioka, Yoshiteru Oshima, Hiroyuki Osada, Natsuko Chiba, Hiroyuki Shibata, Yoshiharu Iwabuchi
ACS MEDICINAL CHEMISTRY LETTERS 1 (6) 273-276 2010/09
DOI：
10.1021/ml1000454
ISSN：
1948-5875
-
Total Synthesis and Determination of the Absolute Configuration of (-)-Idesolide
Peer-reviewed
Hiroyuki Yamakoshi, Masatoshi Shibuya, Masaki Tomizawa, Yuji Osada, Naoki Kanoh, Yoshiharu Iwabuchi
ORGANIC LETTERS 12 (5) 980-983 2010/03
DOI：
10.1021/ol9029676
ISSN：
1523-7060
eISSN：
1523-7052
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Structure-activity relationship of C-5-curcuminoids and synthesis of their molecular probes thereof
Hiroyuki Yamakoshi, Hisatsugu Ohori, Chieko Kudo, Atsuko Sato, Naoki Kanoh, Chikashi Ishioka, Hiroyuki Shibata, Yoshiharu Iwabuchi
BIOORGANIC & MEDICINAL CHEMISTRY 18 (3) 1083-1092 2010/02
DOI：
10.1016/j.bmc.2009.12.045
ISSN：
0968-0896
eISSN：
1464-3391
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Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas
Brian Hutzen, Lauren Friedman, Matthew Sobo, Li Lin, Ling Cen, Stephanie De Angelis, Hiroyuki Yamakoshi, Hiroyuki Shibata, Yoshiharu Iwabuchi, Jiayuh Lin
INTERNATIONAL JOURNAL OF ONCOLOGY 35 (4) 867-872 2009/10
DOI：
10.3892/ijo_00000401
ISSN：
1019-6439
eISSN：
1791-2423
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4 '-Demethylnobiletin, a Bioactive Metabolite of Nobiletin Enhancing PKA/ERK/CREB Signaling, Rescues Learning Impairment Associated with NMDA Receptor Antagonism via Stimulation of the ERK Cascade
Md Al Rahim, Akira Nakajima, Daisuke Saigusa, Naomi Tetsu, Yuji Maruyama, Masatoshi Shibuya, Hiroyuki Yamakoshi, Yoshihisa Tomioka, Yoshiharu Iwabuchi, Yasushi Ohizumi, Tohru Yamakuni
BIOCHEMISTRY 48 (32) 7713-7721 2009/08
DOI：
10.1021/bi901088w
ISSN：
0006-2960
-
Therapeutic potential of newly synthesized curcumin analogs
Peer-reviewed
Shibata Hiroyuki, Kudo Chieko, Sato Atsuko, Ohori Hisatsugu, Yamakoshi Hiroyuki, Ishioka Chikashi, Iwabuchi Yoshiharu
CANCER RESEARCH 69 2009/05/01
ISSN：
0008-5472
-
Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo
Hiroyuki Shibata, Hiroyuki Yamakoshi, Atsuko Sato, Hisatsugu Ohori, Yuichi Kakudo, Chieko Kudo, Yayoi Takahashi, Mika Watanabe, Hiroshi Takano, Chikashi Ishioka, Tetsuo Noda, Yoshiharu Iwabuchi
CANCER SCIENCE 100 (5) 956-960 2009/05
DOI：
10.1111/j.1349-7006.2009.01127.x
ISSN：
1347-9032
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Syntheses of naturally occurring cytotoxic [7.7]paracyclophanes, (-)-cylindrocyclophane A and its enantiomer, and implications for biological activity
Hiroyuki Yamakoshi, Fumiya Ikarashi, Masataka Minami, Masatoshi Shibuya, Tsutomu Sugahara, Naoki Kanoh, Hisatsugu Ohori, Hiroyuki Shibata, Yoshiharu Iwabuchi
ORGANIC & BIOMOLECULAR CHEMISTRY 7 (18) 3772-3781 2009
DOI：
10.1039/b909646a
ISSN：
1477-0520
eISSN：
1477-0539
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Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols
Naoki Kanoh, Takemichi Nakamura, Kaori Honda, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Osada
TETRAHEDRON 64 (24) 5692-5698 2008/06
DOI：
10.1016/j.tet.2008.04.031
ISSN：
0040-4020
-
Synthesis of an enantiomeric DNA oligomer and its T-HgII-T base-pair formation.
Haruta, K., Tanaka, Y., Kawamura, T., Kondo, Y., Ono, A., Yamakoshi, H., Kanoh, N., Iwabuchi, Y.
Nucleic acids symposium series (2004) (51) 187-188 2007/01/01
DOI：
10.1093/nass/nrm094
ISSN：
1746-8272
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Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer
Hisatsugu Ohori, Hiroyuki Yamakoshi, Masaki Tomizawa, Masatoshi Shibuya, Yuichi Kakudo, Atsuko Takahashi, Shin Takahashi, Satoshi Kato, Takao Suzuki, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata
MOLECULAR CANCER THERAPEUTICS 5 (10) 2563-2571 2006/10
DOI：
10.1158/1535-7163.MCT-06-0174
ISSN：
1535-7163
https://orcid.org/0000-0002-9263-577X