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Kenichi Funamoto

Section

Institute of Fluid Science

Job title

Professor

Degree

博士（工学）（東北大学）
修士（情報科学）（東北大学）

researchmap

https://researchmap.jp/read0140794

J-GLOBAL ID

200901053821267972

e-Rad No.

70451630

ORCID

https://orcid.org/0000-0002-0703-0910

Committee Memberships 7

日本機械学会バイオエンジニアリング部門制御と情報－生体への応用－研究会　幹事

2018/04 - Present
Journal of Biomechanical Science and Engineering　Editor

2016/04 - 2022/03
Technical Section on Data Assimilation for Engineering Design　委員

2015/04 - 2017/03
日本機械学会計算力学部門「設計に活かすデータ同化研究会」　委員

2015/04 - 2017/03
Journal of Biomechanical Sicence and Engineering 編集委員会　Editor (Public Relations)

2009/04 - 2016/03
Journal of Biomechanical Sicence and Engineering 編集委員会　広報委員

2009/04 - 2016/03
日本機械学会部門協議会直属分科会「高度物理刺激と生体応答に関する研究分科会(P-SCC12)」　委員

2013/04 - 2015/03

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Professional Memberships 3

Japanese Society for the Study of Cellular slime Molds

2023/04 - Present
The Japan Society of Ultrasonics in Medicine
The Japan Society of Mechanical Engineers

Research Interests 6

Cell
Hypoxia
In vivo microenvironment
Hemodynamics
Measurement-integrated simulation
Microfluidic device

Research Areas 4

Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Fluid engineering /
Life sciences / Medical systems /
Life sciences / Biomaterials /
Life sciences / Biomedical engineering /

Awards 13

Outstanding Abstract Award

2021/12　The 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021)　Migration characteristics of Dictyostelium discoideum depending on oxygen environment
The Young Scientists’ Prize, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology

2019/04　Ministry of Education, Culture, Sports, Science and Technology
2017 JBSE Graphics of the Year Award

2018/03　Journal of Biomechanical Science and Engineering　Effects of upstream bifurcation and bend on the blood flow in a cerebral aneurysm
2015 JBSE Graphics of the Year Award

2016/03　Journal of Biomechanical Science and Engineering　Investigation of characteristic hemodynamic parameters indicating thinning and thickening sites of cerebral aneurysms
日本機械学会バイオエンジニアリング部門瀬口賞

2016/01/09　日本機械学会
日本超音波医学会奨励賞

2010/05/10　日本超音波医学会
日本機械学会奨励賞（研究）

2007/04/06　日本機械学会
東北大学工学研究科長賞

2007/03/26　東北大学
計測自動制御学会東北支部優秀発表奨励賞

2006/05/17　計測自動制御学会
日本機械学会流体工学部門講演会優秀講演賞

2005/10/29　日本機械学会
日本機械学会フェロー賞

2005/01/22　日本機械学会
計測自動制御学会東北支部優秀発表奨励賞

2004/12/23　計測自動制御学会
計測自動制御学会学術奨励賞研究奨励賞

2004/02/23　計測自動制御学会

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Papers 187

Dictyostelium discoideum chemotaxis is altered by hypoxia to orient streaming toward higher oxygen level independently of aerotaxis

Satomi Hirose, Julie Hesnard, Kenichi Funamoto, Jean-Paul Rieu, Christophe Anjard

2025/08/27

DOI： 10.1101/2025.08.22.671833 　
Cell-cultured PDMS vascular model to allow placement of implant devices

Taku Okuno, Kazuyo Ito, Kenichi Funamoto, Daisuke Yoshino

2025/01/24

DOI： 10.1101/2025.01.20.634010 　
Aneurysm Wall Enhancement Can Predict Rupture Point in Intracranial Aneurysms With Multiple Blebs. International-journal Peer-reviewed

Shunsuke Omodaka, Shin-Ichiro Sugiyama, Hiroyuki Sakata, Kenichi Funamoto, Takuhiro Yamaguchi, Kuniyasu Niizuma, Hidenori Endo

Neurosurgery　2024/08/08

DOI： 10.1227/neu.0000000000003134 　

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BACKGROUND AND OBJECTIVES: Ruptured aneurysms visualized by vessel wall MRI (VW-MRI) exhibit characteristic aneurysm wall enhancement (AWE). A secondary bulge of the aneurysmal wall, called a bleb, is often the site of rupture in ruptured aneurysms. We hypothesized that a higher degree of AWE would identify the rupture point in aneurysms with multiple blebs. METHODS: AWE was quantitatively analyzed in consecutive ruptured intracranial aneurysms with multiple blebs (31 aneurysms with a total of 72 blebs) using VW-MRI. A 3-dimensional T1-weighted fast spin-echo sequence was obtained after contrast media injection, and the contrast ratio of the aneurysm wall against the pituitary stalk (CRstalk) was calculated as the AWE indicator. Bleb characteristics, including CRstalk and wall shear stress (WSS), were compared between ruptured and unruptured blebs. Odds ratios with 95% confidence intervals for ruptures were calculated by conditional logistic regression analysis. RESULTS: Ruptured blebs had a higher CRstalk and lower WSS compared with unruptured blebs. CRstalk remained significantly associated with the bleb rupture status in the conditional logistic regression (adjusted odds ratio 3.9, 95% CIs 1.6-9.7). CONCLUSION: AWE is associated with the bleb rupture status independent of WSS. Contrast-enhanced VW-MRI may be a useful noninvasive tool for identifying the rupture point and guiding the treatment strategy.
Hypoxia suppresses glucose-induced increases in collective cell migration in vascular endothelial cell monolayers Peer-reviewed

Kazuki Sone, Yuka Sakamaki, Satomi Hirose, Mai Inagaki, Masanori Tachikawa, Daisuke Yoshino, Kenichi Funamoto

Scientific Reports　14　5164　2024/03/02

DOI： 10.1038/s41598-024-55706-1 　

ISSN： 2045-2322

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<jats:title>Abstract</jats:title><jats:p>Blood glucose levels fluctuate during daily life, and the oxygen concentration is low compared to the atmosphere. Vascular endothelial cells (ECs) maintain vascular homeostasis by sensing changes in glucose and oxygen concentrations, resulting in collective migration. However, the behaviors of ECs in response to high-glucose and hypoxic environments and the underlying mechanisms remain unclear. In this study, we investigated the collective migration of ECs simultaneously stimulated by changes in glucose and oxygen concentrations. Cell migration in EC monolayer formed inside the media channels of microfluidic devices was observed while varying the glucose and oxygen concentrations. The cell migration increased with increasing glucose concentration under normoxic condition but decreased under hypoxic condition, even in the presence of high glucose levels. In addition, inhibition of mitochondrial function reduced the cell migration regardless of glucose and oxygen concentrations. Thus, oxygen had a greater impact on cell migration than glucose, and aerobic energy production in mitochondria plays an important mechanistic role. These results provide new insights regarding vascular homeostasis relative to glucose and oxygen concentration changes.</jats:p>
Biological characterization of breast cancer spheroid formed by fast fabrication method Peer-reviewed

Yuta Iijima, Norino Uenaka, Mayu Morimoto, Daiki Sato, Satomi Hirose, Naoyoshi Sakitani, Masahiro Shinohara, Kenichi Funamoto, Gen Hayase, Daisuke Yoshino

In vitro models　2024/02/13
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s44164-024-00066-3 　

eISSN： 2731-3441
Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans. International-journal Peer-reviewed

Shuhei Murase, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Ayumu Konno, Hirokazu Hirai, Taku Saito, Sakae Tanaka, Keisuke Shinohara, Takuya Kishi, Yuki Yoshikawa, Takamasa Sakai, Makoto Ayaori, Hirohiko Inanami, Koji Tomiyasu, Atsushi Takashima, Toru Ogata, Hirotsugu Tsuchimochi, Shinya Sato, Shigeyoshi Saito, Kohzoh Yoshino, Yuiko Matsuura, Kenichi Funamoto, Yasuhiro Sawada

Nature Biomedical Engineering　2023/07/06

DOI： 10.1038/s41551-023-01061-x 　

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The mechanisms by which physical exercise benefits brain functions are not fully understood. Here, we show that vertically oscillating head motions mimicking mechanical accelerations experienced during fast walking, light jogging or treadmill running at a moderate velocity reduce the blood pressure of rats and human adults with hypertension. In hypertensive rats, shear stresses of less than 1 Pa resulting from interstitial-fluid flow induced by such passive head motions reduced the expression of the angiotensin II type-1 receptor in astrocytes in the rostral ventrolateral medulla, and the resulting antihypertensive effects were abrogated by hydrogel introduction that inhibited interstitial-fluid movement in the medulla. Our findings suggest that oscillatory mechanical interventions could be used to elicit antihypertensive effects.
The aerotaxis of Dictyostelium discoideum is independent of mitochondria, nitric oxide and oxidative stress Peer-reviewed

Satomi Hirose, Julie Hesnard, Nasser Ghazi, Damien Roussel, Yann Voituron, Oliver Cochet-Escartin, Jean-Paul Rieu, Christophe Anjard, Kenichi Funamoto

Frontiers in Cell and Developmental Biology　11　1134011　2023/06/15
Publisher: Frontiers Media {SA}
DOI： 10.3389/fcell.2023.1134011 　

ISSN： 2296-634X

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<jats:p>Spatial and temporal variations of oxygen environments affect the behaviors of various cells and are involved in physiological and pathological events. Our previous studies with <jats:italic>Dictyostelium discoideum</jats:italic> as a model of cell motility have demonstrated that aerotaxis toward an oxygen-rich region occurs below 2% O<jats:sub>2</jats:sub>. However, while the aerotaxis of <jats:italic>Dictyostelium</jats:italic> seems to be an effective strategy to search for what is essential for survival, the mechanism underlying this phenomenon is still largely unclear. One hypothesis is that an oxygen concentration gradient generates a secondary oxidative stress gradient that would direct cell migration towards higher oxygen concentration. Such mechanism was inferred but not fully demonstrated to explain the aerotaxis of human tumor cells. Here, we investigated the role on aerotaxis of flavohemoglobins, proteins that can both act as potential oxygen sensors and modulators of nitric oxide and oxidative stress. The migratory behaviors of <jats:italic>Dictyostelium</jats:italic> cells were observed under both self-generated and imposed oxygen gradients. Furthermore, their changes by chemicals generating or preventing oxidative stress were tested. The trajectories of the cells were then analyzed through time-lapse phase-contrast microscopic images. The results indicate that both oxidative and nitrosative stresses are not involved in the aerotaxis of <jats:italic>Dictyostelium</jats:italic> but cause cytotoxic effects that are enhanced upon hypoxia.</jats:p>
Microfluidic platform for the reproduction of hypoxic vascular microenvironments Peer-reviewed

Naoyuki Takahashi, Daisuke Yoshino, Ryuji Sugahara, Satomi Hirose, Kazuki Sone, Jean-Paul Rieu, Kenichi Funamoto

Scientific Reports　13　(1)　5428　2023/04/03
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1038/s41598-023-32334-9 　

ISSN： 2045-2322

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<jats:title>Abstract</jats:title><jats:p>Vascular endothelial cells (ECs) respond to mechanical stimuli caused by blood flow to maintain vascular homeostasis. Although the oxygen level in vascular microenvironment is lower than the atmospheric one, the cellular dynamics of ECs under hypoxic and flow exposure are not fully understood. Here, we describe a microfluidic platform for the reproduction hypoxic vascular microenvironments. Simultaneous application of hypoxic stress and fluid shear stress to the cultured cells was achieved by integrating a microfluidic device and a flow channel that adjusted the initial oxygen concentration in a cell culture medium. An EC monolayer was then formed on the media channel in the device, and the ECs were observed after exposure to hypoxic and flow conditions. The migration velocity of the ECs immediately increased after flow exposure, especially in the direction opposite to the flow direction, and gradually decreased, resulting in the lowest value under the hypoxic and flow exposure condition. The ECs after 6-h simultaneous exposure to hypoxic stress and fluid shear stress were generally aligned and elongated in the flow direction, with enhanced VE-cadherin expression and actin filament assembly. Thus, the developed microfluidic platform is useful for investigating the dynamics of ECs in vascular microenvironments.</jats:p>
Numerical analysis of hemodynamic changes and blood stagnation in the left ventricle by internal structures and torsional motion Peer-reviewed

Suguru Miyauchi, Koichi Hosoi, Shingo Tsuda, Toshiyuki Hayase, Kenichi Funamoto

AIP Advances　13　(4)　045105　2023/04/01

DOI： 10.1063/5.0143833 　
Region-based SVD processing of high-frequency ultrafast ultrasound to visualize cutaneous vascular networks Peer-reviewed

Anam Bhatti, Takuro Ishii, Naoya Kanno, Hayato Ikeda, Kenichi Funamoto, Yoshifumi Saijo

Ultrasonics　129　106907-106907　2023/03
Publisher: Elsevier BV
DOI： 10.1016/j.ultras.2022.106907 　

ISSN： 0041-624X
Development of Ultrasound Phantom Made of Transparent Material: Feasibility of Optical Particle Image Velocimetry International-journal Peer-reviewed

Muhammad Shiddiq Sayyid Hashuro, Simon Tupin, Narendra Kurnia Putra, Kotaro Daibo, Kosuke Inoue, Takuro Ishii, Hiroyuki Kosukegawa, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta

Ultrasound in Medicine and Biology　49　(6)　1385-1394　2023

DOI： 10.1016/j.ultrasmedbio.2022.12.020 　

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OBJECTIVE: The need for ultrasound flow phantoms to validate ultrasound systems requires the development of materials that can clearly visualize the flow inside for measurement purposes. METHODS: A transparent ultrasound flow phantom material composed of poly(vinyl alcohol) hydrogel (PVA-H) with dimethyl sulfoxide (DMSO) and water solution manufactured using the freezing method and mixed with quartz glass powder to exhibit scattering effects is proposed. To achieve transparency of the hydrogel phantom, the refractive index (RI) was changed to match that of the glass by modifying the PVA concentration and the ratio of DMSO to water in the solvent. The feasibility of optical particle image velocimetry (PIV) was verified by comparing an acrylic rectangular cross-section channel with a rigid wall. After the feasibility tests, an ultrasound flow phantom was fabricated to conduct ultrasound B-mode visualization and Doppler-PIV comparison. DISCUSSION: The results revealed that the PIV measured through PVA-H material exhibited 0.8% error in the measured maximum velocity compared with PIV through the acrylic material. B-mode images are similar to real tissue visualization with a limitation of a higher sound velocity, when compared with human tissue, of 1792 m/s. Doppler measurement of the phantom revealed approximately 120% and 19% overestimation of maximum and mean velocities, respectively, compared with those from PIV. CONCLUSION: The proposed material possesses the advantage of the single-phantom ability to improve the ultrasound flow phantom for validation of flow.
Stiffness of primordial germ cells is required for their extravasation in avian embryos Peer-reviewed

Saito, D., Tadokoro, R., Nagasaka, A., Yoshino, D., Teramoto, T., Mizumoto, K., Funamoto, K., Kidokoro, H., Miyata, T., Tamura, K., Takahashi, Y.

iScience　25　(12)　105629　2022/12
Publisher: Elsevier BV
DOI： 10.1016/j.isci.2022.105629 　

ISSN： 2589-0042
Brain- Targeted Mechanical Intervention Using Passive Head Motion Can Have an Antihypertensive Effect

Yasuhiro Sawada, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Keisuke Shinohara, Takuya Kishi, Ayumu Konno, Hirokazu Hirai, Makoto Ayaori, Hirohiko Inanami, Koji Tomiyasu, Toru Ogata, Hirotsugu Tsuchimochi, Shinya Sato, Shigeyoshi Saito, Kohzoh Yoshino, Kenichi Funamoto, Hiroki Ochi, Masahiro Shinohara, Motoshi Nagao

CIRCULATION　146　2022/11

ISSN： 0009-7322

eISSN： 1524-4539
A Review of Functional Analysis of Endothelial Cells in Flow Chambers Invited Peer-reviewed

Makoto Ohta, Naoya Sakamoto, Kenichi Funamoto, Zi Wang, Yukiko Kojima, Hitomi Anzai

JOURNAL OF FUNCTIONAL BIOMATERIALS　13　(3)　2022/09

DOI： 10.3390/jfb13030092 　

eISSN： 2079-4983
Comparison of hemodynamics in the left ventricle between tricuspid aortic valve and bicuspid aortic valves Peer-reviewed

Shingo Tsuda, Suguru Miyauchi, Kenichi Funamoto

Proceedings of the 13th Pacific Symposium on Flow Visualization and Image Processing (PSFVIP13)　PSFVIP13_paper_9　2022/08
Model-based estimation of QT intervals of mouse fetal electrocardiogram. International-journal Peer-reviewed

Namareq Widatalla, Kiyoe Funamoto, Motoyoshi Kawataki, Chihiro Yoshida, Kenichi Funamoto, Masatoshi Saito, Yoshiyuki Kasahara, Ahsan Khandoker, Yoshitaka Kimura

Biomedical engineering online　21　(1)　45　2022/06/29

DOI： 10.1186/s12938-022-01015-5 　

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BACKGROUND: Abnormal prolongation in the QT interval or long QT syndrome (LQTS) is associated with several cardiac complications such as sudden infant death syndrome (SIDS). LQTS is believed to be linked to genetic mutations which can be understood by using animal models, such as mice models. Nevertheless, the research related to fetal QT interval in mice is still limited because of challenges associated with T wave measurements in fetal electrocardiogram (fECG). Reliable measurement of T waves is essential for estimating their end timings for QT interval assessment. RESULTS: A mathematical model was used to estimate QT intervals. Estimated QT intervals were validated with Q-aortic closure (Q-Ac) intervals of Doppler ultrasound (DUS) and comparison between both showed good agreement with a correlation coefficient higher than 0.88 (r > 0.88, P < 0.05). CONCLUSION: Model-based estimation of QT intervals can help in better understanding of QT intervals in fetal mice.
The Oxygen Gradient in Hypoxic Conditions Enhances and Guides Dictyostelium discoideum Migration Invited Peer-reviewed

Satomi Hirose, Jean-Paul Rieu, Olivier Cochet-Escartin, Christophe Anjard, Kenichi Funamoto

Processes　10　(2)　318-318　2022/02/07
Publisher: {MDPI} {AG}
DOI： 10.3390/pr10020318 　
Aerotaxis and aerokinesis of Dictyostelium discoideum under hypoxic microenvironments Peer-reviewed

Satomi Hirose, Jean-Paul Rieu, Christophe Anjard, Olivier Cochet-Escartin, Haruhisa Kikuchi, Kenichi Funamoto

Proceedings of 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2021 (EMBC2021)　2021　1187-1190　2021/11/01

DOI： 10.1109/EMBC46164.2021.9629752 　

eISSN： 2694-0604
Hypoxia triggers collective aerotactic migration in dictyostelium discoideum Peer-reviewed

Cochet-Escartin, O., Demircigil, M., Hirose, S., Allais, B., Gonzalo, P., Mikaelian, I., Funamoto, K., Anjard, C., Calvez, V., Rieu, J.-P.

eLife　10　e64731　2021/08/20

DOI： 10.7554/eLife.64731 　

ISSN： 2050-084X
P21-activated kinase regulates oxygen-dependent migration of vascular endothelial cells in monolayers Peer-reviewed

Hirose, S., Tabata, Y., Sone, K., Takahashi, N., Yoshino, D., Funamoto, K.

Cell Adhesion and Migration　15　(1)　272-284　2021/01/01
Publisher: Informa {UK} Limited
DOI： 10.1080/19336918.2021.1978368 　

ISSN： 1933-6926 1933-6918
Hydrostatic pressure promotes endothelial tube formation through aquaporin 1 and Ras-ERK signaling Peer-reviewed

Daisuke Yoshino, Kenichi Funamoto, Kakeru Sato, Kenry, Masaaki Sato, Chwee Teck Lim

Communications Biology　3　(1)　2020/12/01

DOI： 10.1038/s42003-020-0881-9 　

eISSN： 2399-3642
Cancer cell migration and cancer drug screening in oxygen tension gradient chip Peer-reviewed

Nam, H., Funamoto, K., Jeon, J.S.

Biomicrofluidics　14　(4)　044107-044107　2020/07
Publisher: AIP Publishing
DOI： 10.1063/5.0011216 　

ISSN： 1932-1058

eISSN： 1932-1058
Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension Peer-reviewed

Rei Koens, Yugo Tabata, Jean C. Serrano, Satoshi Aratake, Daisuke Yoshino, Roger D. Kamm, Kenichi Funamoto

APL Bioengineering　4　(1)　2020/03/01

DOI： 10.1063/1.5127069 　

eISSN： 2473-2877
Measurement of Particle Concentration Profiles of a Dilute Suspension in Different Reynolds Number Conditions

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Miho Tanaka, Mitsuru Tanaka, Shigeru Murata, Suguru Miyauchi

Proceedings of 19th International Symposium on Advanced Fluid Information　164-165　2019/11
Viscosity estimation of a suspension with rigid spheres in circular microchannels using particle tracking velocimetry Peer-reviewed

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Miho Tanaka, Mitsuru Tanaka, Shigeru Murata, Suguru Miyauchi, Toshiyuki Hayase

Micromachines　10　(10)　2019/10/01

DOI： 10.3390/mi10100675 　

eISSN： 2072-666X
Numerical analysis of the blood flow in the left ventricle with internal structures: Effect of trabeculae carneae models and atrial fibrillation Peer-reviewed

Suguru Miyauchi, Tomomi Yamada, Koichi Hosoi, Toshiyuki Hayase, Kenichi Funamoto

AIP Advances　9　(10)　105209-1-105209-10　2019/10/01

DOI： 10.1063/1.5124730 　

eISSN： 2158-3226
Oxygen-dependent contraction and degradation of the extracellular matrix mediated by interaction between tumor and endothelial cells Peer-reviewed

Yoshino, D., Funamoto, K.

AIP Advances　9　(4)　045215-1-045215-1-10　2019/04

DOI： 10.1063/1.5089772 　

ISSN： 2158-3226
Experimental study on the effects of radial dispersion of spherical particles on the suspension rheology Peer-reviewed

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Suguru Miyauchi, Toshiyuki Hayase

ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference, AJKFluids 2019　5　2019

DOI： 10.1115/AJKFluids2019-5322 　
Migration of vascular endothelial cells in monolayers under hypoxic exposure International-journal Peer-reviewed

Yugo Tabata, Daisuke Yoshino, Kiyoe Funamoto, Rei Koens, Roger D Kamm, Kenichi Funamoto

Integrative Biology　11　(1)　26-35　2019/01
Publisher: Oxford University Press ({OUP})
DOI： 10.1093/intbio/zyz002 　

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The hypoxic microenvironment existing in vivo is known to significantly affect cell morphology and dynamics, and cell group behaviour. Collective migration of vascular endothelial cells is essential for vasculogenesis and angiogenesis, and for maintenance of monolayer integrity. Although hypoxic stress increases vascular endothelial permeability, the changes in collective migration and intracellular junction morphology of vascular endothelial cells remain poorly understood. This study reveals the migration of confluent vascular endothelial cells and changes in their adherens junction, as reflected by changes in the vascular endothelial (VE)-cadherin distribution, under hypoxic exposure. Vascular endothelial monolayers of human umbilical vein endothelial cells (HUVECs) were formed in microfluidic devices with controllability of oxygen tension. The oxygen tension was set to either normoxia (21% O2) or hypoxia (<3% O2) by supplying gas mixtures into separate gas channels. The migration velocity of HUVECs was measured using particle image velocimetry with a time series of phase-contrast microscopic images of the vascular endothelial monolayers. Hypoxia inducible factor-1α (HIF-1α) and VE-cadherin in HUVECs were observed after exposure to normoxic or hypoxic conditions using immunofluorescence staining and quantitative confocal image analysis. Changes in the migration speed of HUVECs were observed in as little as one hour after exposure to hypoxic condition, showing that the migration speed was increased 1.4-fold under hypoxia compared to that under normoxia. Nuclear translocation of HIF-1α peaked after the hypoxic gas mixture was supplied for 2 h. VE-cadherin expression was also found to be reduced. When ethanol was added to the cell culture medium, cell migration increased. By contrast, by strengthening VE-cadherin junctions with forskolin, cell migration decreased gradually in spite the effect of ethanol to stimulate migration. These results indicate that the increase of cell migration by hypoxic exposure was attributable to loosening of intercellular junction resulting from the decrease of VE-cadherin expression.
Numerical and experimental studies on non-Newtonian rheology of a suspension

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Suguru Miyauchi, Toshiyuki Hayase

Proceedings of the 18th International Symposium on Advanced Fluid Information　2018/11
Initial response of cell-cell junction in endothelial monolayer to hypoxic exposure

FUNAMOTO Kenichi, YOSHINO Daisuke, NAKAYAMA Masafumi

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2018.30　1A11　2018
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2018.30.1a11 　

eISSN： 2424-2829
Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images Peer-reviewed

Tomomi Yamada, Toshiyuki Hayase, Suguru Miyauchi, Kenichi Funamoto

Journal of Biomechanical Science and Engineering　13　(2)　17-00597-1-17-00597-14　2018

DOI： 10.1299/jbse.17-00597 　

ISSN： 1880-9863
Microfluidic device for co-culture under controlled oxygen tension

Kenichi Funamoto, Daisuke Yoshino

Abstract book of the 3rd International Symposium on Mechanobiology (ISMB2017)　242　2017/12/11
Estimation of viscosity profiles of semidilute suspensions by computational and experimental studies

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Toshiyuki Hayase

Proceedings of the 17th International Symposium on Advanced Fluid Information (AFI-2017)　78-79　2017/11/01
Endothelial monolayer permeability under controlled oxygen tension Peer-reviewed

Kenichi Funamoto, Daisuke Yoshino, Kento Matsubara, Ioannis K. Zervantonakis, Kiyoe Funamoto, Masafumi Nakayama, Jun Masamune, Yoshitaka Kimura, Roger D. Kamm

INTEGRATIVE BIOLOGY　9　(6)　529-538　2017/06

DOI： 10.1039/c7ib00068e 　

ISSN： 1757-9694

eISSN： 1757-9708
Photoplethysmography and ultrasonic-measurement-integrated simulation to clarify the relation between two-dimensional unsteady blood flow field and forward and backward waves in a carotid artery Peer-reviewed

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING　55　(5)　719-731　2017/05

DOI： 10.1007/s11517-016-1543-4 　

ISSN： 0140-0118

eISSN： 1741-0444
Ultrasound Imaging of Mouse Fetal Intracranial Hemorrhage Due to Ischemia/Reperfusion Peer-reviewed

Kenichi Funamoto, Takuya Ito, Kiyoe Funamoto, Clarissa L. Velayo, Yoshitaka Kimura

FRONTIERS IN PHYSIOLOGY　8　(340)　1-6　2017/05

DOI： 10.3389/fphys.2017.00340 　

ISSN： 1664-042X
Deformation of stenotic blood vessel model made from Poly (Vinyl Alcohol) Hydrogel by hydrostatic pressure Peer-reviewed

Yasutomo Shimizu, Lei Liu, Hiroyuki Kosukegawa, Kenichi Funamoto, Toshiyuki Hayase, Toshio Nakayama, Makoto Ohta

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2016, VOL. 3　V003T04A055　2017

DOI： 10.1115/IMECE2016-66657 　
Effects of upstream bifurcation and bend on the blood flow in a cerebral aneurysm Peer-reviewed

Daichi Suzuki, Kenichi Funamoto, Shin-ichiro Sugiyama, Toshiyuki Hayase, Suguru Miyauchi, Teiji Tominaga

Journal of Biomechanical Science and Engineering　12　(4)　17-00189-1-17-00189-11　2017
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jbse.17-00189 　

ISSN： 1880-9863
Numerical analysis for elucidation of mechanical interaction between an erythrocyte moving in medium subject to inclined centrifugal force and endothelial cells on a plate Peer-reviewed

Akira Yatsuyanagi, Toshiyuki Hayase, Suguru Miyauchi, Kenichi Funamoto, Kosuke Inoue, Atsushi Shirai, Luca Brandt

Journal of Fluid Science and Technology　11　(4)　JFST0029　2016/12/28

DOI： 10.1299/jfst.2016jfst0029 　
Daughter Sac Formation Related to Blood Inflow Jet in an Intracranial Aneurysm Peer-reviewed

Sin-ichiro Sugiyama, Hidenori Endo, Shunsuke Omodaka, Toshiki Endo, Kuniyasu Niizuma, Sherif Rashad, Toshio Nakayama, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga

WORLD NEUROSURGERY　96　396-402　2016/12

DOI： 10.1016/j.wneu.2016.09.040 　

ISSN： 1878-8750

eISSN： 1878-8769
Microfluidic experiments of cellular responses to hypoxia Invited

Kenichi Funamoto

Proceedings of the 13th International Conference on Flow Dynamics (ICFD2016)　324-325　2016/10/11
Preliminary study for fluid dynamic effects of upstream bifurcation and bend on blood flow simulation in cerebral aneurysm

Daichi Suzuki, Kenichi Funamoto, Shin-ichiro Sugiyama, Toshiyuki Hayase, Suguru Miyauchi, Teiji Tominaga

Proceedings of the 13th International Conference on Flow Dynamics (ICFD2016)　264-265　2016/10/11
Analysis of an autonomic nervous system of mouse fetus with congenital heart defect

Kiyoe Funamoto, Rika Sugibayashi, Kenichi Funamoto, Kana Nakanishi, Takuya Ito, Motoyoshi Kawataki, Toshiyuki Hayase, Yoshitaka Kimura

Proceedings of the 16th International Symposium on Advanced Fluid Information (AFI-2016)　92-93　2016/10/11
Computational and experimental studies on the blood cells behavior in microcirculation

Tomohiro Fukui, Misa Kawaguchi, Atsuhide Kitagawa, Kenichi Funamoto, Toshiyuki Hayase

Proceedings of the 16th International Symposium on Advanced Fluid Information (AFI-2016)　82-83　2016/10/11
Computational investigation toward selective collection of water particles containing odorous molecules by electrostatic spraying Peer-reviewed

Jin Muraoka, Kenichi Funamoto, Mariko Seno, Satoshi Arimoto, Ken Shimono, Satoshi Suzuki, Yoshio Mitsutake, Tetsuya Maekawa, Toshihiko Yoshioka, Toshiyuki Hayase

JOURNAL OF ELECTROSTATICS　83　35-41　2016/10

DOI： 10.1016/j.elstat.2016.07.004 　

ISSN： 0304-3886

eISSN： 1873-5738
NOVEL REDUCED UTERINE PERFUSION PRESSURE (RUPP) MODEL OF PREECLAMPSIA IN MICE Peer-reviewed

Fushima Tomofumi, Sekimoto Akiyo, Minato Takahiro, Ito Takuya, Oe Yuji, Kisu Kiyomi, Sato Emiko, Funamoto Kenichi, Kimura Yoshitaka, Ito Sadayoshi, Sato Hiroshi, Takahashi Nobuyuki

JOURNAL OF HYPERTENSION　34　E237　2016/09

DOI： 10.1097/01.hjh.0000500527.66210.66 　

ISSN： 0263-6352
Effects of inflow velocity profile on two-dimensional hemodynamic analysis by ordinary and ultrasonic-measurement-integrated simulations Peer-reviewed

Takaumi Kato, Shusaku Sone, Kenichi Funamoto, Toshiyuki Hayase, Hiroko Kadowaki, Nobuyuki Taniguchi

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING　54　(9)　1331-1339　2016/09

DOI： 10.1007/s11517-015-1376-6 　

ISSN： 0140-0118

eISSN： 1741-0444
Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice Peer-reviewed

Tomofumi Fushima, Akiyo Sekimoto, Takahiro Minato, Takuya Ito, Yuji Oe, Kiyomi Kisu, Emiko Sato, Kenichi Funamoto, Toshiyuki Hayase, Yoshitaka Kimura, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi

PLOS ONE　11　(5)　e0155426　2016/05

DOI： 10.1371/journal.pone.0155426 　

ISSN： 1932-6203
Properties of convective delivery in spinal cord gray matter: laboratory investigation and computational simulations Peer-reviewed

Toshiki Endo, Yushi Fujii, Shin-ichiro Sugiyama, Rong Zhang, Shogo Ogita, Kenichi Funamoto, Ryuta Saito, Teiji Tominaga

JOURNAL OF NEUROSURGERY-SPINE　24　(2)　359-366　2016/02

DOI： 10.3171/2015.5.SPINE141148 　

ISSN： 1547-5654

eISSN： 1547-5646
Study of Estimation Method for Unsteady Inflow Velocity in Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Simulation Peer-reviewed

Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Nobuyuki Taniguchi

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING　63　(2)　403-414　2016/02

DOI： 10.1109/TBME.2015.2461559 　

ISSN： 0018-9294

eISSN： 1558-2531
Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously Peer-reviewed

Shin-ichiro Sugiyama, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE　2386031　2016

DOI： 10.1155/2016/2386031 　

ISSN： 1748-670X

eISSN： 1748-6718
Study of Permeability Changes of Endothelial Cell Monolayer Exposed to Hypoxia

K. Matsubara, K. Funamoto, I.K. Zervantonakis, K. Funamoto, T. Ito, Y. Kimura, T. Hayase, R.D. Kamm

Proceedings of the 12th International Conference on Flow Dynamics (ICFD2015)　362-363　2015/10/29
Determination of Optimum Feedback Gain of Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis System

H. Kadowaki, T. Hayase, K. Funamoto, S. Miyauchi, K. Inoue, T. Shimazaki, T. Jibiki, K. Miyama

Proceedings of the 12th International Conference on Flow Dynamics (ICFD2015)　460-461　2015/10/29
Fundamental Study of Interaction between Erythrocyte and Endothelial Cell under Inclined Centrifugal Force (Physical Explanation of Interaction Model)

A. Yatsuyagagi, T. Hayase, S. Miyauchi, K. Funamoto, K. Inoue, A. Shirai, L. Brandt

Proceedings of 12th International Conference on Flow Dynamics (ICFD2015)　320-321　2015/10/28
Numerical Analysis of Ultrasound Scattering Property of Medium Mimicking Blood (Influence of Ultrasound Frequency)

Y. Chiba, T. Hayase, S. Miyauchi, K. Funamoto

Proceedings of the 12th International Conference on Flow Dynamics (ICFD2015)　308-309　2015/10/28
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound

R. Sugibayashi, T. Ito, K. Funamoto, T. Hayase, Y. Kimura

Proceedings of the 15th International Symposium on Advanced Fluid Information (AFI-2015)　184-185　2015/10/28
Investigation of Inlet Position in Hemodynamic Analysis of a Cerebral Aneurysm

D. Suzuki, K. Funamoto, S. Sugiyama, T. Hayase, S. Miyauchi, T. Tominaga

Proceedings of the 12th International Conference on Flow Dynamics (ICFD2015)　304-305　2015/10/27
Effect of Speckle Noise in Ultrasonic Measurement on Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis Peer-reviewed

H. Kadowaki, T. Hayase, K. Funamoto, S. Miyauchi, K. Inoue, T. Shimazaki, T. Jibiki, K. Miyama

Proceedings of the World Congress on Electrical Engineering and Computer Systems and Science (EECSS 2015)　323-1-323-8　2015/07/15
Measurements of Blood Flow and Blood Pressure under Different Indoor Temperature and Body Postural Conditions, and Development of a New Human Simulation Model Peer-reviewed

H. Sakamoto, Y. Chiba, T. Hayase, K. Funamoto, Y. Saijo, T. Goto

Healthy Buildings Europe 2015　437-1-437-8　2015/05/18
Numerical analysis of hemodynamic changes in the left atrium due to atrial fibrillation Peer-reviewed

Ryo Koizumi, Kenichi Funamoto, Toshiyuki Hayase, Yusuke Kanke, Muneichi Shibata, Yasuyuki Shiraishi, Tomoyuki Yambe

JOURNAL OF BIOMECHANICS　48　(3)　472-478　2015/02

DOI： 10.1016/j.jbiomech.2014.12.025 　

ISSN： 0021-9290

eISSN： 1873-2380
Microscopic observation of glass bead movement in soft tissue-mimicking phantom under ultrasound PW mode scanning Peer-reviewed

Lei Liu, Kenichi Funamoto, Masayuki Tanabe, Toshiyuki Hayase

JOURNAL OF MEDICAL ULTRASONICS　42　(1)　59-63　2015/01

DOI： 10.1007/s10396-014-0565-5 　

ISSN： 1346-4523

eISSN： 1613-2254
Poly(vinyl alcohol) gel ultrasound phantom with durability and visibility of internal flow Peer-reviewed

Kenichi Funamoto, Osamu Yamashita, Toshiyuki Hayase

JOURNAL OF MEDICAL ULTRASONICS　42　(1)　17-23　2015/01

DOI： 10.1007/s10396-014-0560-x 　

ISSN： 1346-4523

eISSN： 1613-2254
Blood flow analysis in carotid artery bifurcation by two-dimensional ultrasonic-measurement-integrated simulation Peer-reviewed

Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Shusaku Sone, Tadashi Shimazaki, Takao Jibiki, Koji Miyama

Journal of Biomechanical Science and Engineering　10　(1)　1-14　2015
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jbse.14-00266 　

ISSN： 1880-9863
Investigation of characteristic hemodynamic parameters indicating thinning and thickening sites of cerebral aneurysms Peer-reviewed

Daichi Suzuki, Kenichi Funamoto, Shinichiro Sugiyama, Toshio Nakayama, Toshiyuki Hayase, Teiji Tominaga

Journal of Biomechanical Science and Engineering　10　(1)　1-10　2015
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jbse.14-00265 　

ISSN： 1880-9863
Numerical Analysis for Elucidation of Nonlinear Frictional Characteristics of a Deformed Erythrocyte Moving on a Plate in Medium Subject to Inclined Centrifugal Force Peer-reviewed

Takashi Oshibe, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME　136　(12)　121003-1-121003-9　2014/12

DOI： 10.1115/1.4028723 　

ISSN： 0148-0731

eISSN： 1528-8951
Development and feasibility study of a two-dimensional ultrasonic-measurement-integrated blood flow analysis system for hemodynamics in carotid arteries Peer-reviewed

Takaumi Kato, Kenichi Funamoto, Toshiyuki Hayase, Shusaku Sone, Hiroko Kadowaki, Tadashi Shimazaki, Takao Jibiki, Koji Miyama, Lei Liu

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING　52　(11)　933-943　2014/11

DOI： 10.1007/s11517-014-1193-3 　

ISSN： 0140-0118

eISSN： 1741-0444
Analysis of High Reynolds Number Flow behind a Square Cylinder by Hybrid Wind Tunnel (Improvement of Critical Gain of Instability for Pressure Feedback)

Jumpei Okutani, Toshiyuki Hayase, Kosuke Inoue, Shusaku Sone, Kenichi Funamoto

Proceedings of the Eleventh International Conference on Flow Dynamics (ICFD2014)　270-271　2014/10/10
Application of MR-Measurement-Integrated Hemodynamic Simulation to Cerebrovascular Diseases

S. Sugiyama, K. Funamoto, D. Suzuki, T. Hayase, T. Tominaga

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　104-105　2014/10/09
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound

R. Sugibayashi, T. Ito, K. Funamoto, T. Hayase, Y. Kimura

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　94-95　2014/10/09
Elucidation of Mechanisms of the Frictional Characteristics of Erythrocytes under Inclined Centrifugal Force

K. Funamoto, L. Brandt, A. Yatsuyanagi, K. Inoue, T. Hayase

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　100-101　2014/10/09
Evaluation of Permeability of Endothelial Cell Monolayer under Controlled Oxygen Tension

K. Funamoto, I.K. Zervantonakis, K. Matsubara, K. Funamoto, T. Ito, Y. Kimura, R.D. Kamm

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　102-103　2014/10/09
Investigation on Advanced Medical Ultrasound Imaging Technology

M. Tanabe, H. Hashimoto, K. Funamoto, Y. Chiba, T. Hayase

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　192-193　2014/10/09
Observation of Hypoxia Cellular Response by Using Microfluidic Devices

S. Fukushima, K. Funamoto

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　98-99　2014/10/09
Fundamental Study of Interaction between Erythrocyte and Endothelial Cell under Inclined Centrifugal Force (Reproduction of Friction Characteristics by Numerical Analysis Using Simple Interaction Model)

Akira Yatsuyanagi, Toshiyuki Hayase, Kenichi Funamoto, Kosuke Inoue, Atsushi Shirai

Proceedings of the Eleventh International Conference on Flow Dynamics (ICFD2014)　296-297　2014/10/08
Studies on the basic technology of “Sono-cytometry” Peer-reviewed

Yosuke Komatsu, Ryo Nagaoka, Kenichi Funamoto, Toshiyuki Hayase, Nobuo Masauzi, Hiroshi Kanai, Yoshifumi Saijo

Transactions of Japanese Society for Medical and Biological Engineering　52　351-O-352　2014/08/17
Publisher: Japan Soc. of Med. Electronics and Biol. Engineering
DOI： 10.11239/jsmbe.52.O-351 　

ISSN： 1347-443X 1881-4379
Simultaneous Analysis System for Blood Pressure and Flow Using Ultrasonic-Measurement-Integrated Simulation

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

Abstracts of the 7th World Congress of Biomechanics　F5　2014/07/11
Observation of Extracellular Collagen Remodeling by Second-Harmonic-Generation Microscopy

S. Fukushima, R. Maehara, T. Araki, K. Funamoto, R.D. Kamm

Abstracts of the 7th World Congress of Biomechanics　2014/07/06
2B26 Development of Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation : Evaluation of Wave Intensity Using Developed System

Shusaku SONE, Toshiyuki HAYASE, Kenichi FUNAMOTO, Atsushi SHIRAI

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2014.26　(0)　311-312　2014
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2014.26.311 　

eISSN： 2424-2829
"Sonocytometry" - Novel Diagnostic Method of Ultrasonic Differentiation of Cells in Blood Flow Peer-reviewed

Yosuke Komatsu, Ryo Nagaoka, Ken-ichi Funamoto, Toshiyuki Hayase, Nobuo Masauzi, Hiroshi Kanai, Yoshifumi Saijo

2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2761-2764　2014

DOI： 10.1109/EMBC.2014.6944195 　

ISSN： 1557-170X
Effects of Time-Varying Feedback Signals on Pressure Field in Ultrasonic-Measurement-Integrated Simulation of Pulsatile Blood Flow Peer-reviewed

K. Funamoto, T. Hayase

Proceedings of the 3rd International Conference on Computational and Mathematical Biomedical Engineering (CMBE13)　295-298　2013/12/17
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound

T. Ito, K. Funamoto, R. Sugibayashi, K. Funamoto, C. Velayo, M. Endo, Y. Dong, T. Hayase, Y. Kimura

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　60-61　2013/11/26
Development of a Microfluidic Device for a Three-Dimensional Cell Culture under a Controlled Hypoxic Environment

K. Funamoto, I. K. Zervantonakis, R. D. Kamm

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　184-185　2013/11/26
Effects of Temporal and Spatial Oxygen Heterogeneity on Cell Processes

K. Funamoto, I. K. Zervantonakis, K. Funamoto, T. Ito, Y. Kimura, R. D. Kamm

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　92-93　2013/11/26
Evaluation of Intracranial Aneurysm Rupture Using MR-Measurement-Integrated Simulation

S. Sugiyama, K. Funamoto, D. Suzuki, T. Hayase, T. Tominaga

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　86-87　2013/11/26
In-Depth Investigation of Twinkling Sign: Optical Observation of Ultrasound Radiation Force Driven Oscillation of Glass Particle

L. Liu, K. Funamoto, M. Tanabe, T. Hayase

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　58-59　2013/11/26
Numerical Simulation of Ultrasound Imaging for Detection of Microcalcification in Soft Tissue

M. Tanabe, E. Tagomori, L. Liu, K. Funamoto, M. Nishimoto, T. Hayase

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　62-63　2013/11/26
Observation of Hypoxia Cellular Response by Using Microfluidic Devices

S. Fukushima, R. Maehara, K. Funamoto

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　90-91　2013/11/26
Improvement of Simultaneous Analysis System for Blood Pressure and Flow Velocity Using Photoplethymography and Ultrasonic-Measurement-Integrated Simulation

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

Proceedings of the 7th East Asian Consortium on Biomedical Engineering　66-67　2013/11/18
Consideration on the Evaluation Function of Blood Flow Rate Estimation in Ultrasonic-Measurement-Integrated Simulation

Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Shusaku Sone, Takao Jibiki, Hiroshi Hashimoto, Koji Miyama, Lei Liu

Proceedings of 7th East Asian Consortium on Biomedical Engineering　64-65　2013/11/18
Computational simulation of convection-enhanced drug delivery in the non-human primate brainstem: a simple model predicting the drug distribution Peer-reviewed

Shin-ichiro Sugiyama, Ryuta Saito, Kenichi Funamoto, Toshio Nakayama, Yukihiko Sonoda, Yoji Yamashita, Tomoo Inoue, Toshihiro Kumabe, Toshiyuki Hayase, Teiji Tominaga

NEUROLOGICAL RESEARCH　35　(8)　773-781　2013/10

DOI： 10.1179/1743132813Y.0000000215 　

ISSN： 0161-6412
Ultrasonic-Measurement-Integrated Simulation of Complex Blood Flow

K. Funamoto, T. Hayase

Proceedings of the International Workshop on Flow Dynamics Related to Energy, Aerospace and Material Science　1-2　2013/09/11
In vitro study of ultrasound radiation force-driven twinkling sign using PVA-H gel and glass beads tissue-mimicking phantom. Peer-reviewed

Lei Liu, Kenichi Funamoto, Kei Ozawa, Makoto Ohta, Toshiyuki Hayase, Masafumi Ogasawara

Journal of medical ultrasonics (2001)　40　(3)　197-203　2013/07

DOI： 10.1007/s10396-012-0429-9 　

More details Close

The twinkling sign observed in ultrasound coded-excitation imaging (e.g., GE B-Flow) has been reported in previous research as a potential phenomenon to detect micro calcification in soft tissue. However, the mechanism of the twinkling sign has not been clearly understood yet. We conducted an in vitro experiment to clarify the mechanism of the twinkling sign by measuring a soft tissue-mimicking phantom with ultrasonic and optical devices. A soft tissue-mimicking phantom was made of poly(vinyl alcohol) hydro (PVA-H) gel and 200-μm-diameter glass beads. We applied ultrasound to the phantom using medical ultrasound diagnostic equipment to observe the twinkling sign of glass beads. Optical imaging with a laser sheet and a high-speed camera was performed to capture the scatter lights of the glass beads with and without ultrasound radiation. The scatter lights from the glass beads were quantified and analyzed to evaluate their oscillations driven by the ultrasound radiation force. The twinkling sign from the glass beads embedded in the PVA-H gel soft tissue phantom was observed in ultrasound B-Flow color imaging. The intensity and oscillation of the scattered lights from the glass beads showed significant difference between the cases with and without ultrasound radiation. The results showed a close relationship between the occurrence of the twinkling sign and the variations of the scatter lights of glass beads, indicating that ultrasound radiation force-driven micro oscillation causes the twinkling sign of micro calcification in soft tissue.
Reproduction of pressure field in ultrasonic-measurement-integrated simulation of blood flow Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING　29　(7)　726-740　2013/07

DOI： 10.1002/cnm.2522 　

ISSN： 2040-7939

eISSN： 2040-7947
Frictional Characteristics of Erythrocytes on Endothelia-Cultured or Material-Coated Glass Plates Subject to Inclined Centrifugal Forces Invited

Toshiyuki Hayase, Kousuke Inoue, Kenichi Funamoto, Atsushi Shirai

Proceedings of 8th International Conference on Multiphase Flow　1-8　2013/05/29
INFLUENCE OF PLAQUE STIFFNESS ON CHANGE OF BLOOD VESSEL GEOMETRY LEADING HEMODYNAMICAL CHANGES IN PVA-H STENOSIS MODELS Peer-reviewed

Yasutomo Shimizu, Shuya Shida, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta

INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2012, VOL 2: BIOMEDICAL AND BIOTECHNOLOGY　IMECE2012　455-460　2013

DOI： 10.1115/IMECE2012-87073 　
Fundamental Study on Micro Calcification Detection Using Twinkling Sign (TS): The Effect of Stiffness of Surrounding Tissue on the Appearance of TS Peer-reviewed

Lei Liu, Kenichi Funamoto, Masayuki Tanabe, Toshiyuki Hayase

2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　1390-1393　2013

DOI： 10.1109/EMBC.2013.6609769 　

ISSN： 1557-170X
Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation Peer-reviewed

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　1827-1830　2013

DOI： 10.1109/EMBC.2013.6609878 　

ISSN： 1557-170X
Erratum to "Influence of surface model extraction parameter on computational fluid dynamics modeling of cerebral aneurysms" [Journal of Biomechanics 45 (2012) 2355-2361] Peer-reviewed

Shunsuke Omodaka, Takashi Inoue, Kenichi Funamoto, Shin-ichirou Sugiyama, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

Journal of Biomechanics　45　(16)　2947　2012/11/15

DOI： 10.1016/j.jbiomech.2012.09.012 　

ISSN： 0021-9290 1873-2380
A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture under a controlled hypoxic environment Peer-reviewed

Kenichi Funamoto, Ioannis K. Zervantonakis, Yuchun Liu, Christopher J. Ochs, Choong Kim, Roger D. Kamm

LAB ON A CHIP　12　(22)　4855-4863　2012/11

DOI： 10.1039/c2lc40306d 　

ISSN： 1473-0197
Hemodynamic Analysis of Growing Intracranial Aneurysms Arising from a Posterior Inferior Cerebellar Artery Peer-reviewed

Shin-Ichiro Sugiyama, Hui Meng, Kenichi Funamoto, Takashi Inoue, Miki Fujimura, Toshio Nakayama, Shunsuke Omodaka, Hiroaki Shimizu, Akira Takahashi, Teiji Tominaga

WORLD NEUROSURGERY　78　(5)　462-468　2012/11

DOI： 10.1016/j.wneu.2011.09.023 　

ISSN： 1878-8750
Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope - Effect of Asymmetric Cell Shape on the Motion

Takashi OSHIBE, Toshiyuki HAYASE, Kenichi FUNAMOTO, Atsushi SHIRAI

Proceedings of the 9th International Conference on Flow Dynamics (ICFD2012)　756-757　2012/09/20
Rheological Analysis of the Mechanism of Fetal Brain Hemorrhage

T. Ito, K. Funamoto, K. Funamoto, T. Hayase, Y. Kimura

Proceedings of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　116-117　2012/09/20
Computational Simulation to Create Low Oxygen Tension in a Microfluidic Device for Cell Culture

K. Funamoto, I.K. Zervantonakis, Y. Liu, C.J. Ochs, R.D. Kamm

Proceedings of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　88-89　2012/09/20
Ultrasound Radiation Force Driven B-Flow Twinkling Sign for Microcalcification Detection

L. Liu, K. Funamoto, K. Ozawa, M. Ohta, T. Hayase, M. Ogasawara

Proceedings of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　86-87　2012/09/20
Observation of Hypoxia Cellular Response by Using Microfluidic Devices

S. Fukushima, R. Maehara, K. Funamoto

Proceedings of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　122-123　2012/09/20
Magnetic Resonance Fluid Dynamics for Intracranial Aneurysms

S. Sugiyama, K. Funamoto, T. Hayase, T. Tominaga

Proceedings of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　118-119　2012/09/20
Oxygen Tension Control in a Microfluidic Device for Cell Culture Invited

K. Funamoto, I.K. Zervantonakis, Y. Liu, R.D. Kamm

Proceedings of the 9th International Conference on Flow Dynamics (ICFD2012)　724-725　2012/09/19
Intra-left Atrial Flow

M. Shibata, T. Yambe, K. Funamoto, T. Hayase

Proceedings of the 9th International Conference on Flow Dynamics (ICFD2012)　404-405　2012/09/19
Influence of surface model extraction parameter on computational fluid dynamics modeling of cerebral aneurysms Peer-reviewed

Shunsuke Omodaka, Takashi Inoue, Kenichi Funamoto, Shin-ichirou Sugiyama, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

JOURNAL OF BIOMECHANICS　45　(14)　2355-2361　2012/09

DOI： 10.1016/j.jbiomech.2012.07.006 　

ISSN： 0021-9290
Neumerical and Experimental Study of Flow in Stenosis models with Several Mechanical Properties

Yasutomo Shimizu, Shuya Shida, Ashkan Javadzadegan, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta

Proceedings Ninth International Conference on Flow Dynamics　422-423　2012/09
Oxygen sensors for microfluidic 3D cell cultures

C.J. Ochs, K. Funamoto, R.D. Kamm, D. Trau

EUROPT(R)ODE XI Conference on Optical Chemical Sensors and Biosensors　98　2012/04/02
Local Hemodynamics at the Rupture Point of Cerebral Aneurysms Determined by Computational Fluid Dynamics Analysis Peer-reviewed

Shunsuke Omodaka, Shin-ichirou Sugiyama, Takashi Inoue, Kenichi Funamoto, Miki Fujimura, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

CEREBROVASCULAR DISEASES　34　(2)　121-129　2012

DOI： 10.1159/000339678 　

ISSN： 1015-9770
Flow Analysis of Rupture Point in Cerebral Aneurysms: Computational Fluid Dynamics Study

S. Omodaka, T. Inoue, K. Funamoto, S. Sugiyama, M. Fujimura, H. Shimizu, T. Hayase, A. Takahashi, T. Tominaga

Proceedings on the 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　68-69　2011/12/13
Numerical Analysis of the Effect of Angle of Attack on a Red Blood Cell Moving in an Inclined Centrifuge Microscope

T. Oshibe, T. Hayase, K. Funamoto, A. Shirai

Proceedings on the 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　82-83　2011/12/13
Two-Dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow in Bifurcation of Carotid Artery

H. Kadowaki, K. Funamoto, T. Hayase, S. Sone, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings on the 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　80-81　2011/12/13
Implementation of visual data mining for unsteady blood flow field in an aortic aneurysm Peer-reviewed

Seiichiro Morizawa, Koji Shimoyama, Shigeru Obayashi, Kenichi Funamoto, Toshiyuki Hayase

JOURNAL OF VISUALIZATION　14　(4)　393-398　2011/12

DOI： 10.1007/s12650-011-0101-2 　

ISSN： 1343-8875
Comparison between Ultrasonic-Measurement-Integrated Simulation and Ordinary Simulation with Measured Upstream Velocity Condition

S. Sone, T. Kato, K. Funamoto, T. Hayase, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings of the 8th International Conference on Flow Dynamics　456-457　2011/11/10
Computational Simulation of Blood Flow in Intracranial Aneurysms under Patient-Specific Pulsatile Inlet Condition

S. Sugiyama, K. Funamoto, T. Hayase, T. Tominaga

Proceedings of the 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　90-91　2011/11/10
Detection of Microcalcification in Soft Tissue Employing B-Flow ”Twinkling” Sign

L. Liu, K. Ozawa, K. Funamoto, M. Ohta, T. Hayase, M. Ogasawara

Proceedings of the 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　94-95　2011/11/10
Left Atrial Vortex

M. Shibata, T. Yambe, K. Funamoto, T. Hayase

Proceedings of the 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　88-89　2011/11/10
Rheological Analysis of the Mechanism of Fetal Brain Hemorrhage

T. Ito, K. Funamoto, K. Funamoto, K. Tanabe, A. Nakamura, T. Hayase, Y. Kimura

Proceedings of the 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　86-87　2011/11/10
Volumetric and Angiogenic Evaluation of Antitumor Effects with Acoustic Liposome and High-Frequency Ultrasound Peer-reviewed

Tetsuya Kodama, Noriko Tomita, Yoko Yagishita, Sachiko Horie, Kenichi Funamoto, Toshiyuki Hayase, Maya Sakamoto, Shiro Mori

CANCER RESEARCH　71　(22)　6957-6964　2011/11

DOI： 10.1158/0008-5472.CAN-11-2389 　

ISSN： 0008-5472
Integration of Ultrasound Color Doppler Imaging and Numerical Simulation

K. Funamoto, T. Kato, T. Hayase

Proceedings of the 2nd International Conference on Computational and Mathematical Biomedical Engineering (CMBE11)　262-265　2011/04/01
Numerical Analysis of Effects of Measurement Errors on Ultrasonic-Measurement-Integrated Simulation Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING　58　(3)　653-663　2011/03

DOI： 10.1109/TBME.2010.2095418 　

ISSN： 0018-9294
Hemodynamic changes in the left atrium due to atrial fibrillation

Kenichi Funamoto, Ryo Koizumi, Toshiyuki Hayase, Muneichi Shibata, Tomoyuki Yambe

ASME 2011 Summer Bioengineering Conference, SBC 2011　1131-1132　2011

DOI： 10.1115/SBC2011-53817 　
Blood Flow Analysis in the Left Atrium with/without Atrial Fibrillation

R. Koizumi, K. Funamoto, T. Hayase, M. Shibata

Proceedings on the 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　96-97　2010/12/16
Experimental Validation of Ultrasonic-Measurement-Integrated Blood Flow Simulation Using Carotid Artery Models

T. Sawao, K. Funamoto, T. Hayase

Proceedings on the 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　158-159　2010/12/15
Stabilization of Measurement-Integrated Simulation by Elucidation of Destabilizing Mechanism Peer-reviewed

Toshiyuki Hayase, Kentaro Imagawa, Kenichi Funamoto, Atsushi Shirai

Journal of Fluid Science and Technology　5　(3)　632-647　2010/12
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jfst.5.632 　

ISSN： 1880-5558

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Measurement-integrated (MI) simulation is a numerical flow analysis method with a feedback mechanism from measurement of a real flow. It correctly reproduces a real flow under inherent ambiguity in a mathematical model or a computational condition. In this paper we theoretically investigated the destabilization phenomenon of MI simulation, in which analysis error suddenly increases at some critical feedback gain. This phenomenon has been considered as instability of a closed-loop feedback system, but present study treated it as that of a numerical scheme. First, the mechanism of the destabilization phenomenon was investigated based on the sufficient condition of the convergence of iterative calculation of existing MI simulation. It was found that the feedback signal in the source term destabilized the iterative calculation. Then, a new MI simulation scheme was derived by evaluating the feedback signal in the linear term to remove the cause of the destabilization. The validity of the present theoretical analysis was verified for examples treated in former studies of MI simulations: blood flow in an aneurismal aorta with ultrasonic measurement, blood flow in a cerebral aneurism with magnetic resonance measurement, Karman vortex street behind a square cylinder with PIV measurement, and fully developed turbulent flow in a square duct with ideal measurement. Occurrences of destabilization phenomenon in all the examples were well explained by the condition of this study, especially for cases of relatively small time steps and large feedback gains. Furthermore, the new MI simulation scheme realized the analysis without the destabilization phenomenon. The present theoretical result confirming that the destabilization phenomenon is not the instability of the feedback system but that of a numerical scheme is generally applicable to MI simulations using the velocity error for the feedback signal.
Computer Simulation Predicts the Convective Drug Distribution in the Primate Brainstem

S. Sugiyama, R. Saito, K. Funamoto, Y. Sonoda, T. Kumabe, T. Hayase, T. Tominaga

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　98-99　2010/11/02
Consideration for Simulations of Infusion in Realistic Animal Brain Geometries

J. H. Smith, K. Funamoto, K. A. Starkweather, T. Hayase

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　96-97　2010/11/02
Detection of Microcalcification in Soft Tissue

L. Liu, M. Ogasawara, K. Ozawa, K. Funamoto, M. Ohta, T. Hayase

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　80-81　2010/11/02
Evaluation of Wall Shear Stress on Carotid Artery with Ultrasonic-Measurement-Integrated Simulation

T. Kato, K. Funamoto, T. Hayase, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings of the seventh International Conference on Flow Dynamics　542-543　2010/11/02
Fluid Analysis of the Mechanism of Fetal Brain Hemorrhage

T. Ito, K. Funamoto, K. Funamoto, K. Tanabe, A. Nakamura, T. Hayase, Y. Kimura

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　78-79　2010/11/02
Left Atrial Appendage

M. Shibata, T. Yambe, T. Yamaguchi, R. Koizumi, K. Funamoto, T. Hayase

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　94-95　2010/11/02
Computational Simulation on Convection-Enhanced Drug Delivery into the Primate Brain

S. Sugiyama, T. Nakayama, K. Funamoto, T. Hayase, T. Tominaga

Abstracts of the 6th World Congress of Biomechanics　578-579　2010/08/04
Determination of Local Fine Structure of Blood Flows by Measurement Coupled Simulation Invited

T. Hayase, K. Funamoto, K. Imagawa

Proceedings of 12th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　89-92　2010/03
Clinical Application of Ultrasonic-Measurement-Integrated Simulation for Diagnosis of Carotid Artery

K. Funamoto, T. Kato, T. Hayase, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings of SMART-Tohoku GCOE joint Workshop on Micro & Nano Bioengineering: MIT, NUS, NTU and Tohoku　41-42　2010/01/12
Visual Data Mining for Unsteady Blood Flow Field, Peer-reviewed

S. Morizawa, K. Shimoyama, S. Obayashi, K. Funamoto, T. Hayase

OE-001　2010
VISUALIZATION OF MICROCIRCULATION BASED ON BRIGHTNESS VARIATION IN CONTRAST-ENHANCED ULTRASOUND

Kenichi Funamoto, Toshiyuki Hayase, Tetsuya Kodama

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, 2010　219-220　2010

DOI： 10.1115/SBC2010-19349 　
Effect of Measurement Error on Ultrasonic-Measurement-Integrated Simulation of Blood Flow in an Aortic Aneurysm

K. Funamoto, T. Hayase, Y. Saijo, T. Yambe

6TH WORLD CONGRESS OF BIOMECHANICS (WCB 2010), PTS 1-3　31　1652-+　2010

ISSN： 1680-0737
Analysis of Clinical Data with Ultrasonic-Measurement-Integrated Simulation

T. Kato, K. Funamoto, T. Hayase, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings of the 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　102-103　2009/12
Dynamic Characteristics Analysis of Diseased Circulatory System with Lumped Parameter Model 1st Report : Heart Valve Disease

R. Koizumi, T. Hayase, K. Funamoto

Proceedings of the 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　6-7　2009/12
Eigenvalue Analysis for Error Dynamics of Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aneurismal Aorta

K. Imagawa, T. Hayase, K. Funamoto

Proceedings of the 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　114-115　2009/12
Three-Dimensional Ultrasonic-Measurement-Integrated Blood flow Simulation using PVA Carotid Artery Model

T. Suzuki, T. Hayase, K. Funamoto, K. Inoue

Proceedings of the 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　116-117　2009/12
Atrial Vortex

M. Shibata, H. Ito, T. Yambe, R. Koizumi, K. Funamoto, T. Hayase

Proceedings of the 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　64-65　2009/11/05
Blood Flow Analysis by Measurement-Integrated Simulation

K. Funamoto, T. Hayase

Proceedings of the 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　120-121　2009/11/05
Convection-enhanced Delivery of ACNU under MRI Monitoring against Recurrent Gliomas-Development of Computational Simulation of Drug Distribution

R. Saito, Y. Sonoda, T. Kumabe, K. Funamoto, T. Hayase, T. Tominaga

Proceedings of the 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　72-73　2009/11/05
Fundamental Study of Convection-Enhanced Delivery Simulation in Rat Brain

J.H. Smith, K. Funamoto, M.V. Racenis, T. Hayase

Proceedings of the 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　70-71　2009/11/05
Numerical Validation of MR-Measurement-Integrated Simulation of Blood Flow in a Cerebral Aneurysm Peer-reviewed

Kenichi Funamoto, Yoshitsugu Suzuki, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

ANNALS OF BIOMEDICAL ENGINEERING　37　(6)　1105-1116　2009/06

DOI： 10.1007/s10439-009-9689-y 　

ISSN： 0090-6964
Effect of Aliasing on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow

K. Funamoto, T. Hayase, K. Imagawa, Y. Saijo, T. Yambe

Proceedings of the 10th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　18-19　2009/04/17
Fluid-Structure Coupled Ultrasonic-Measurement-Integrated Simulation of Fluid in Elastic Tube with Contraction

L. Liu, T. Hayase, K. Funamoto

Proceedings of 9th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　106-107　2009/03
NUMERICAL EXPERIMENT OF MR-MEASUREMENT-INTEGRATED SIMULATION OF STEADY BLOOD FLOW IN A CEREBRAL ANEURYSM

Kenichi Funamoto, Yoshitsugu Suzuki, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE 2008, PTS A AND B　1089-1090　2009
Numerical Evaluation of MR-Measurement-Integrated Simulation of Unsteady Hemodynamics in a Cerebral Aneurysm

K. Funamoto, Y. Suzuki, T. Hayase, T. Kosugi, H. Isoda

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2188-+　2009

ISSN： 1680-0737
Numerical Experiment of Transient and Steady Characteristics of Ultrasonic-Measurement-Integrated Simulation in Three-Dimensional Blood Flow Analysis Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

ANNALS OF BIOMEDICAL ENGINEERING　37　(1)　34-49　2009/01

DOI： 10.1007/s10439-008-9600-2 　

ISSN： 0090-6964
REPRODUCTION OF BLOOD FLOW FIELD BY NUMERICAL SIMULATION INTEGRATED WITH ULTRASONIC MEASUREMENT WITH NOISE

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B　455-456　2009

DOI： 10.1115/SBC2009-206596 　
Development of Poly (Vinyl Alchol) Gel with in vivo Acoustic Properties

Osamu Yamashita, Kenichi Funamoto, Toshiyuki Hayase

Proceedings of GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　30-31　2008/12
Physics Data Mining for Three-Dimensional Unsteady Blood Flow Field in an Aneurysmal Aorta

Shinichiro Morizawa, Koji Shimoyama, Shigeru Obayashi, Kenichi Funamoto, Toshiyuki Hayase

Proceedings of the 8th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　74-75　2008/12
Frictional characteristics of erythrocytes on coated glass plates subject to inclined centrifugal forces Peer-reviewed

Takashi Kandori, Toshiyuki Hayase, Kousuke Inoue, Kenichi Funamoto, Takanori Takeno, Makoto Ohta, Motohiro Takeda, Atsushi Shirai

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME　130　(5)　2008/10

DOI： 10.1115/1.2948420 　

ISSN： 0148-0731
Numerical experiment for Ultrasonic-Measurement-Integrated simulation of three-dimensional unsteady blood flow Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

ANNALS OF BIOMEDICAL ENGINEERING　36　(8)　1383-1397　2008/08

DOI： 10.1007/s10439-008-9519-7 　

ISSN： 0090-6964
Development of Material Close to Anatomy: Experimental Apparatus to Measure Acoustic Properties

Osamu Yamashita, Kenichi Funamoto, Toshiyuki Hayase

Proceedings of Tohoku-NUS Student Joint Symposium　6-7　2008/05
Numerical Evaluation of Ultrasonic-Measurement-Integrated Simulation of Blood Flow

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of 5th International Bio-Fluid Symposium and Workshop　116-117　2008/03
Numerical Experiment for Ultrasonic-Measurement-Integrated Simulation of Developed Laminar Pipe Flow Using Axisymmetric Model Peer-reviewed

Lei Liu, Kenichi Funamoto, Toshiyuki Hayase

Journal of Biomechanical Science and Engineering　3　(2)　101-115　2008

DOI： 10.1299/jbse.3.101 　

ISSN： 1880-9863
Effect of Time Resolution of Measurement on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow in an Aneurysmal Aorta

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 3rd Tohoku-NUS Joint Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region　13-16　2007/12
Three-Dimensional Flow Simulation around a Deformed Red Blood Cell Moving on a Flat Plate

Yuki Okuyama, Toshiyuki Hayase, Kenichi Funamoto

Proceedings of the 7th International Symposium on Advanced Fluid Information and the 4th International Symposium on Transdisciplinary Fluid Integration (AFI/TFI-2007)　60-61　2007/12
MR-Measurement-Integrated Simulation of Blood Flow in a Cerebral Aneurysm

Yoshitsugu Suzuki, Kenichi Funamoto, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

Proceedings of the 7th International Symposium on Advanced Fluid Information and the 4th International Symposium on Transdisciplinary Fluid Integration (AFI/TFI-2007)　58-59　2007/12
Numerical Realization of Blood Flow in Aneurysmal Aorta by Integrating Measurement and Simulation

Toshiyuki Hayase, Kenichi Funamoto, Takayuki Yamagata, Lei Liu, Atsushi Shirai, Makoto Ohta, Kosuke Inoue, Yoshifumi Saijo, Tomoyuki Yambe

Future Medical Engineering Based on Bionanotechnology　857-868　2007
Accuracy of Ultrasonic-Measurement-Integrated simulation for three-dimensional blood flow in aneurysmal aorta Peer-reviewed

K. Funamoto, T. Hayase, Y. Saijo, T. Yambe

FEDSM 2007: PROCEEDINGS OF THE 5TH JOINT ASME/JSME FLUIDS ENGINEERING SUMMER CONFERENCE, VOL 2, PTS A AND B　733-738　2007

DOI： 10.1115/FEDSM2007-37497 　
Numerical study on variation of feedback methods in ultrasonic-measurement-integrated simulation of blood flow in the aneurysmal aorta Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing　49　(1)　144-155　2006/09/15

DOI： 10.1299/jsmec.49.144 　

ISSN： 1344-7653 1347-538X
Improvement of Accuracy of Blood Flow Simulation by Integrating Measurement Using Ultrasonic Doppler Method

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 5th World Congress of Biomechanics　CD-ROM　2006/07
Fundamental Study of Transient Characteristics of Ultrasonic-Measurement-Integrated Simulation toward Reproduction of Unsteady Blood Flows

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of ASME 2006 Summer Bioengineering Conference　CD-ROM　2006/06
637 Blood Flow Simulation Integrated with Ultrasonic Measurement : 6^<th> Report : Three-Dimensional Unsteady Blood Flow Simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2006　195-196　2006
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2006.5.0_195 　

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Development and progress of circulatory diseases are closely related to the hemodynamics in the blood vessel. However, detailed and accurate information of blood flow field has yet to be obtained due to the limitations both in measurement and numerical simulation. Hence, we have proposed the Ultrasonic-Measurement-Integrated (UMI) simulation. In this method, feedback signals derived from the difference between measured and computed Doppler velocities are fed back to the numerical simulation. The transient and steady characteristics of the UMI simulation have been revealed. In this paper, we performed the numerical experiment aiming at the reproduction of the three-dimensional unsteady flow field. As the result, the application of the feedback in the UMI simulation made the computational results converge and trace to the model of real blood flow.
S-14 超音波による心臓・血管の中の流れの医工学的解析(特別企画II(要望演題5) 逆流性疾患・閉塞性疾患・拡張性疾患に対する治療戦略-管と流れと-,第43回日本小児外科学会総会)

西條芳文, 白石泰之, 関根一光, 山家智之, 田中元直, 田林晄一, 早瀬敏幸, 船本健一, 大槻茂雄, 菅原重生

日本小児外科学会雑誌　42　(3)　355-355　2006
Publisher: 特定非営利活動法人日本小児外科学会
DOI： 10.11164/jjsps.42.3_355_2 　
Blood Flow Simulation Coupled with Ultrasonic Measurement

Toshiyuki Hayase, Kenichi Funamoto

Proceedings of the 1st Japan Korea Student Workshop　2　2006
Effect of Feedback Domain in Ultrasonic-Measurement-Integrated Simulation on Reproduction of Blood Flow Field in an Aneurysmal Aorta

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)　62-63　2005/11
Ultrasonic-Measurement-Integrated Simulation for Reproduction of Three-Dimensional Blood Flow Field in the Aorta with Aneurysm

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of ASME 2005 Summer Bioengineering Conference　CD-ROM　2005/06
Fundamental study of ultrasonic-measurement-integrated simulation of real blood flow in the aorta Peer-reviewed

K Funamoto, T Hayase, A Shirai, Y Saijo, T Yambe

ANNALS OF BIOMEDICAL ENGINEERING　33　(4)　415-428　2005/04

DOI： 10.1007/s10439-005-2495-2 　

ISSN： 0090-6964
Effect of Density of Monitoring Points for Feedback in Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta with Aneurysm Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 3rd IASTED International Conference on Biomedical Engineering (BioMED2005)　118-123　2005/02
1108 Blood Flow Simulation Integrated with Ultrasonic Measurement : 4^<th> Report: Improvement of Accuracy of Computational Hemodynamics

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2005　89-90　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2005.5.0_89 　

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Hemodynamics plays an important role in the development, progress and rupture of aneurysms, and therefore, is essential for advanced diagnosis. However, existing methodologies have yet to provide detailed and accurate information of blood flow field due to their individual limitations. As a solution to the problem, we have proposed Ultrasonic-Measurement-Integrated (UMI) simulation. In this method, feedback signals derived from the difference between measured Doppler velocity and the calculated one by numerical simulation are fed back to the numerical simulation. In this paper, we validate the efficacy of three-dimensional UMI simulation by the numerical analysis with various irradiation methods of ultrasonic beam. As the result, UMI simulation improves computational accuracy and enables us to obtain more accurate information of blood flow field including wall shear stress.
410 Study of Three-dimensional Feedback Law for Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the JSME Bioengineering Conference and Seminar　2004　151-152　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2004.17.0_151 　
Detection and correction of aliasing in ultrasonic measurement of blood flows with Ultrasonic-Measurement-Integrated simulation Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Technology and Health Care　13　(4)　331-344　2005

ISSN： 0928-7329
Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta with an Aneurysm

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 4th International Symposium on Advanced Fluid Information and the 1st International Symposium on Transdisciplinary Fluid Integration (AFI/TFI-2004)　16-21　2004/11
Application of Ultrasonic-Measurement-Integrated Simulation to Blood Flow

Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology　78-79　2004/06
Basic Study of Ultrasonic-Measurement-Integrated Simulation System

YAMAGATA Takayuki, Funamoto Kenichi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2004　57-58　2004
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.5.0_57 　

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Detailed information of the velocity and pressure field of the blood flow is essential to establish an advanced diagnosis and treatment of serious circulatory diseases. Commonly used medical measurement equipments cannot measure such information, while even state-of-the-art numerical simulation cannot reproduce real blood flow accurately. In order to overcome this problem, the authors have proposed a new technique, Ultrasonic-Measurement-Integrated (UMI) simulation, that integrates ultrasonic measurement equipment and numerical, simulation, and revealed its usefulness by numerical simulation. The present report describes the development of fundamental procedure of the interface between ultrasonic equipment and simulation, and acceleration of computational speed for real time operation. By considering the tolerance of the solution, computational speed has been accelerated by a factor of 90 achieving only ten times longer computational time than real phenomena.
Analysis of Blood Flow in Aorta with Ultrasonic-Measurement-Integrated Simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2004　39-40　2004
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.7.0_39 　

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In order to reproduce the blood velocity and pressure fields of the blood flow for an accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms, we are developing a new analysis methodology, namely Ultrasonic-Measurement-Integrated (UMI) simulation, by integrating color Doppler ultrasonography and numerical simulation. In the UMI simulation, feedback signals are added to the governing equations to compensate for the difference between computation and measurement. In this paper, we perform UMI simulation for the blood flow in descending aorta with an aneurysm. It is revealed that the UMI simulation reproduces the complicated blood flow structure and detects the incorrect measurement data.
Reproduction of Real Blood Flow in Aorta with Ultrasonic-Measurement-Integrated Simulation

Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

Proceedings of the 3rd International Symposium on Advanced Fluid Information (AFI-2003)　39-40　2003/11
Two-dimensional computational flow analysis and frictional characteristics model for red blood cell under inclined centrifuge microscopy Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai

JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing　46　(4)　1304-1311　2003
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jsmec.46.1304 　

ISSN： 1344-7653

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Misc. 79

マイクロ流体デバイスにより解明される細胞性粘菌の酸素に対する走性 Invited

廣瀬理美, 船本健一

アグリバイオ　6　(7)　90-93　2022/07/20
マイクロ流体デバイスを用いた真核細胞モデルの走気性の観察 Invited

廣瀬理美, 船本健一

細胞　54　(7)　38-41　2022/06/20
酸素濃度制御マイクロ流体デバイスによる細胞動態の観察 Invited

荒武聖, 船本健一

細胞　54　(3)　47-50　2022/02/22
Preface

Takashi Tokumasu, Hitomi Anzai, Koji Fujita, Kenichi Funamoto, Makoto Hirota, Hisashi Nakamura, Koji Shimoyama, Hidemasa Takana

JOURNAL OF FLUID SCIENCE AND TECHNOLOGY　16　(1)　2021

DOI： 10.1299/jfst.2021jfst0001 　

ISSN： 1880-5558
Microfluidic device to reproduce in vivo hypoxic microenvironments Invited

Kenichi Funamoto

The Cell　52　(4)　50-53　2020/03/20
二次元超音波計測融合血流解析における超音波計測のスペックルノイズの影響

門脇弘子, 早瀬敏幸, 船本健一, 宮内優, 井上浩介, 島崎正, 地挽隆夫, 見山広二

超音波テクノ　28　(3)　15-20　2016/06/01
Publisher: 日本工業出版株式会社
2D34 Investigation of Permeability of Endothelial Cell Monolayer by Using Microfluidic Device with Controllability of Oxygen Tension

MATSUBARA Kento, FUNAMOTO Kenichi, ZERVANTONAKIS Ioannis K., FUNAMOTO Kiyoe, ITO Takuya, MASAMUNE Jun, KIMURA Yoshitaka, HAYASE Toshiyuki, KAMM Roger D.

2016　(28)　"2D34-1"-"2D34-5"　2016/01/09
Publisher: The Japan Society of Mechanical Engineers

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Permeability changes of an endothelial cell (EC) monolayer are related to many diseases. This study evaluated permeability of the EC monolayer under normoxia and hypoxia by using fluorescent dextrans of two different molecular weights in a microfluidic device with controllability of oxygen tension. As the results, permeability of the EC monolayer increased by hypoxic exposure, and the increase of the permeability measured by fluorescent dextran of 10 kDa was smaller than that measured by fluorescent dextran of 70 kDa. The results indicated that the size-selectivity of EC monolayer became weaken under hypoxia.
B106 Measurement of permeability of endothelial monolayer under hypoxia by using microfluidic device

MATSUBARA Kento, FUNAMOTO Kenichi, ZERVANTONAKIS Ioannis K., FUNAMOTO Kiyoe, ITO Takuya, MASAMUNE Jun, KIMURA Yoshitaka, HAYASE Toshiyuki, KAMM Roger D.

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2015　(26)　35-36　2015/10/01
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
2A24 Investigation of setting of upstream boundary in computational hemodynamic analysis in a cerebral aneurysm

SUZUKI Daichi, FUNAMOTO Kenichi, SUGIYAMA Shin-ichiro, HAYASE Toshiyuki, TOMINAGA Teiji

2015　(27)　317-318　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
1D42 Measurement of frictional characteristics of erythrocytes on endothelial cells with an inclined centrifuge microscope : influence of normal component of inclined centrifugal force

INOUE Kosuke, HAYASE Toshiyuki, FUNAMOTO Kenichi, SHIRAI Atsushi

2015　(27)　169-170　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
1B11 Investigation on reproduction of pressure field by three-dimensional unsteady ultrasonic-measurement-integrated blood flow simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki

2015　(27)　49-50　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
1B13 Experimental validation of analysis accuracy in two-dimensional ultrasonic-measurement-integrated simulation system

KADOWAKI Hiroko, HAYASE Toshiyuki, FUNAMOTO Kenichi, INOUE Kosuke, SHIMAZAKI Tadashi, JIBIKI Takao, MIYAMA Koji

2015　(27)　53-54　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
1C34 Evaluation of permeability of endothelial monolayer by using hypoxia microfluidic device

MATSUBARA Kento, FUNAMOTO Kenichi, Zervantonakis Ioannis, FUNAMOTO Kiyoe, ITO Takuya, MASAMUNE Jun, KIMURA Yoshitaka, HAYASE Toshiyuki, KAMM Roger

2015　(27)　121-122　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
超音波計測と計測融合シミュレーションによる血圧場と血流場の同時解析システム

曾根周作, 早瀬敏幸, 船本健一, 白井敦

バイオエンジニアリング講演会講演論文集　27th　2015

ISSN： 1348-2920
Twinkling Sign機序解明のための超音波照射による微粒子挙動の光学観察

LIU LEI, FUNAMOTO KEN'ICHI, TANABE MASAYUKI, HAYASE TOSHIYUKI

超音波医学　41　(Suppl.)　S449-S449　2014/04/15
Publisher: (一社)日本超音波医学会
ISSN： 1346-1176
超音波計測融合シミュレーションにおける血流量推定精度の向上

門脇弘子, 早瀬敏幸, 船本健一, 曾根周作, 島崎正, 地挽隆夫, 見山広二, 劉磊

超音波医学　41　(Suppl.)　S480-S480　2014/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
光電脈派計測と超音波計測融合解析による血圧血流同時計測システムによるWI解析

曾根周作, 早瀬敏幸, 船本健一, 白井敦

超音波医学　41　(Suppl.)　S480-S480　2014/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
ソノサイトメトリーの基盤技術の検討

小松洋介, 長岡亮, 船本健一, 早瀬敏幸, 政氏伸夫, 金井浩, 西條芳文

超音波医学　41　(Suppl.)　S481-S481　2014/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
1C22 Angiogenic remodeling of extracellular matrix in microfluidic device

NAGASUGA Daisuke, FUKUSHIMA Shuichiro, FUNAMOTO Kenichi, ARAKI Tsutomu

2014　(26)　79-80　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
1G11 Comparison of hemodynamic parameters and wall characteristics of cerebral aneurysms

SUZUKI Daichi, FUNAMOTO Kenichi, SUGIYAMA Shin-ichiro, NAKAYAMA Toshio, HAYASE Toshiyuki, TOMINAGA Teiji

2014　(26)　207-208　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2B25 Validations of 3D blood vessel reconstruction and blood flow analysis by ultrasonic-measurement-integrated flow-structure interaction simulation system for small animals

SAKANISHI Sanga, HAYASE Toshiyuki, FUNAMOTO Kenichi, SONE Shusaku

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2014　(26)　309-310　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2014.26.309 　
2B46 The influence of axial variation of the plane flow rate on two-dimensional ultrasonic-measurement-integrated simulation of blood flow in a common carotid artery

MATSUMOTO Takuya, FUNAMOTO Kenichi, HAYASE Toshiyuki

2014　(26)　335-336　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2B47 Consideration on the evaluation function of blood flow rate estimation in ultrasonic-measurement-integrated simulation

KADOWAKI Hiroko, HAYASE Toshiyuki, FUNAMOTO Kenichi, SONE Shusaku, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji, LIU Lei

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2014　337-338　2014
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2014.26.337 　
168 Fundamental Study of Interaction between Red Blood Cell and Endothelial Cell under Inclined Centrifugal Force : Reproduction of Friction Characteristics by Numerical Analysis Using Interaction Model

YATSUYANAGI Akira, HAYASE Toshiyuki, INOUE Kosuke, FUNAMOTO Kenichi, SHIRAI Atsushi

2014　(49)　133-134　2014
Publisher: The Japan Society of Mechanical Engineers
MR計測融合シミュレーションによる脳動脈瘤破裂予測

杉山慎一郎, 船本健一, 早瀬敏幸, 清水宏明, 冨永悌二

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2013　2014
軟組織内微細石灰化Twinkling Signに関する実験的研究:粒子径,粒子種類が与える影響

LIU LEI, FUNAMOTO KEN'ICHI, TANABE MASAYUKI, HAYASE TOSHIYUKI

超音波医学　40　(Suppl.)　S408-S408　2013/04/15
Publisher: (一社)日本超音波医学会
ISSN： 1346-1176
3D06 Observation of behavior of cancer cells under hypoxia using microfluidic device

FUNAMOTO Kenichi, ZERVANTONAKIS Ioannis K.

2013　(25)　563-564　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
3C14 Comparison of three-dimensional blood flow analysis in cerebral aneurysm with MRI measurement

SUZUKI Daichi, FUNAMOTO Kenichi, HAYASE Toshiyuki, SUGIYAMA Shin-ichiro

2013　(25)　547-548　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
2A08 Validation of two-dimensional ultrasonic-measurement-integrated simulation for three-dimensional blood flow in common carotid artery

MATSUMOTO Takuya, FUNAMOTO Kenichi, HAYASE Toshiyuki

2013　(25)　247-248　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
2A10 Analysis of blood flow in mouse carotid artery by ultrasonic-measurement-integrated flow-structure interaction simulation system for small animal

SAKANISHI Sanga, HAYASE Toshiyuki, FUNAMOTO Kenichi, SONE Shusaku

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2013　(25)　251-252　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2013.25.251 　
2A09 Estimation of Blood Viscosity Based on Ultrasonic-Measurement-Integrated Simulation

KADOWAKI Hiroko, FUNAMOTO Kenichi, HAYASE Toshiyuki, SONE Shusaku, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji, LIU Lei

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2013　(25)　249-250　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2013.25.249 　
超音波Mモードイメージングと光電容積脈波センシングによる脈波同定の比較

曾根周作, 早瀬敏幸, 船本健一

超音波医学　40　2013

ISSN： 1346-1176
超音波計測融合シミュレーションによる生体内の血液粘度の推定

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 地挽隆夫, 橋本浩, 見山広二, LIU Lei

超音波医学　40　2013

ISSN： 1346-1176
MR計測融合シミュレーションによる脳動脈瘤破裂予測

杉山慎一郎, 船本健一, 早瀬敏幸, 清水宏明, 冨永悌二

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2012　2013
OS3-2-2 Microfluidic Device to Control Oxygen Tension in Cellular Experiment

Funamoto Kenichi, Zervantonakis Ioannis K., Liu Yuchun, Kamm Roger D.

2012　(4)　77-78　2012/10/21
Publisher: The Japan Society of Mechanical Engineers

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Hypoxic microenvironment affects cell fate, and regulates various physiological and pathological phenomena. We designed a microfluidic device to control oxygen tension for three-dimensional cell culture. A polycarbonate (PC) film was embedded in the device to overcome oxygen diffusion from the top surface. Numerical simulations were performed to investigate changes of oxygen tension upon varying the media and gas flow rates. In addition, oxygen tension created based on the computational optimization was validated by using a ruthenium-coated oxygen-sensing glass cover slip. The computational results revealed that there was the optimum combination of the flow rates of media and gas to control oxygen tension, showing establishments of a low uniform oxygen tension (<3%) or an oxygen gradient. The experimental results agreed well with the corresponding computational results.
C207 Improvement of extraction of vessel shape in ultrasonic-measurement-integrated flow-structure interaction simulation system for small animal experiment

Sakanishi Sanga, Hayase Toshiyuki, Funamoto Kenichi, Sone Shusaku

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2012　(23)　181-182　2012/10/04
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2012.23.181 　

ISSN： 1348-2939
A103 Blood Flow Analysis in Carotid Bifurcation with Two-Dimensional Ultrasonic-Measurement-Integrated Simulation

Kadowaki Hiroko, Funamoto Kenichi, Hayase Toshiyuki, Sone Shusaku, Ogasawara Masafumi, Jibiki Takao, Hashimoto Hiroshi, MIYAMA Koji

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2012　(23)　5-6　2012/10/04
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2012.23.5 　

ISSN： 1348-2939
Visual Synergetics(9)Realization of Blood Flow Dynamics based on Visual Synergetics

17　4p　2012/05
Publisher: 日本計算工学会
8F24 Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope : 2nd Report: Validity of Rigid Red Blood Cell Model for Reproduction of Friction Characteristics

OSHIBE Takashi, HAYASE Toshiyuki, FUNAMOTO Kenichi, SHIRAI Atsushi

2012　(24)　"8F24-1"-"8F24-2"　2012/01/06
Publisher: The Japan Society of Mechanical Engineers
頸動脈分岐部内血流の2次元超音波計測融合シミュレーョン

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

バイオエンジニアリング講演会講演論文集　24th (CD-ROM)　2012

ISSN： 1348-2920
2次元超音波計測融合シミュレーションによる頸動脈分岐部の非定常血流量推定

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

超音波医学　39　2012

ISSN： 1346-1176
MR計測融合シミュレーションによる脳動脈瘤破裂予測

杉山慎一郎, 船本健一, 清水宏明, 冨永悌二, 早瀬敏幸

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2011　2012
B120 Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope

OSHIBE Takashi, HAYASE Toshiyuki, FUNAMOTO Kenichi, SHIRAI Atsushi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2011　(22)　77-78　2011/10/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
超音波計測融合シミュレーションと計測による上流速度を与えたシミュレーションの比較

曾根周作, 加藤宇海, 船本健一, 早瀬敏幸, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

超音波医学　38　2011

ISSN： 1346-1176
脳動脈瘤破裂点の流体力学的特徴:コンピュータ流体解析による検討

面高俊介, 井上敬, 船本健一, 杉山慎一郎, 藤村幹, 清水宏明, 早瀬敏幸, 高橋明, 冨永悌二

脳循環代謝　23　(1)　2011

ISSN： 0915-9401
B215 Evaluation of Wall Shear Stress in Carotid Artery with Ultrasonic-Measurement-Integrated Simulation

KATO Takaumi, FUNAMOTO Kenichi, HAYASE Toshiyuki, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2010　(21)　113-114　2010/11/11
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B214 Development of Ultrasonic-Measurement-Integrated Simulation System for Small Animal Experiment : Confirmation Experiment

TANAKA Yuji, FUNAMOTO Kenichi, HAYASE Toshiyuki, INOUE Kosuke

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2010　(21)　111-112　2010/11/11
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
A104 Blood Flow Analysis in the Left Atrium with/without Atrial Fibrillation

KOIZUMI Ryo, FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIBATA Muneichi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2010　(21)　7-8　2010/11/11
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
W205 Blood Flow Simulation Integrated with Medical Measurement

Funamoto Kenichi, Hayase Toshiyuki

Fluids engineering conference ...　2010　619-622　2010/10/29
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882

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Measurement-integrated (MI) simulation, in which feedback signals are applied to the governing equations based on errors between measurement and numerical simulation, has been investigated to solve various problems related to fluid flows. As medical applications of MI simulation, the authors have proposed integration of medical measurement, such as ultrasound Doppler measurement or phase-contrast MRI (PC MRI), of blood flow velocity and a numerical simulation. Effects of feedback of errors in one- or three-directional velocity information between ultrasound Doppler measurement or PC MRI and the numerical simulation were examined by numerical experiments, respectively. Each MI simulation converged to the standard solution and yielded the hemodynamic stresses accurately and in detail.
Fluid-Structure Interaction Simulation of a Red Blood Cell under Inclined Centrifugal Force

15　(2)　561-564　2010/05
Publisher: 日本計算工学会
ISSN： 1342-145X
214 Eigenvalue Analysis of Measurement-Integrated Simulation of Two-Dimensional Blood Flow in the Vinicity of Aneurysm in the Descending Aorta

Funamoto Takakazu, Hayase Toshiyuki, Imagawa Kentaro, Funamoto Kenichi

2010　(45)　228-229　2010/03/12
Publisher: The Japan Society of Mechanical Engineers
0624 Dynamic Characteristics Analysis of Diseased Circulatory System with Lumped Parameter Model : 2^<nd> Report:Ventricular Septal Defect

KOIZUMI Ryo, HAYASE Toshiyuki, FUNAMOTO Kenichi

2009　(22)　279-279　2010/01/08
Publisher: The Japan Society of Mechanical Engineers
Effect of Feedback of Zeroed Doppler Velocity on Ultrasonic-Measurement-Integrated Simulation of Blood Flow

Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

2010　216-216　2010
Publisher: 日本流体力学会

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Ultrasonic-measurement-integrated (UMI) simulation, in which feedback signals are applied to the governing equations based on errors between ultrasonic measurement and numerical simulation, has been investigated for reproduction of the blood flow field. In this study, the effects of wall filter and lack of data, which provide zero Doppler velocity, on UMI simulation were examined by a numerical experiment dealing with the blood flow field in the descending aorta with an aneurysm. Effects of wall filter and lack of data appeared in diastole and in the whole period, respectively. However, by not adding feedback signals where measured Doppler velocities were zero, the computational accuracy of the UMI simulation substantially improved for the sake of the feedback.
B212 Dynamic Characteristics Analysis of Diseased Circulatory System with Lumped Parameter Model 1^<st> Report : Heart Valve Disease

KOIZUMI Ryo, HAYASE Toshiyuki, FUNAMOTO Kenichi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　115-116　2009/11/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B108 Analysis of Clinical Data with Ultrasonic-Measurement-Integrated Simulation

KATTO Takaumi, FUNAMOTO Kenichi, HAYASE Toshiyuki, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　43-44　2009/11/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B213 Blood Flow Simulation Integrated with Ultrasonic Measurement 9^<th> Report : Effect of Noise in Ultrasonic Measurement

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　117-118　2009/11/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
医療計測と数値シミュレーションを融合した血管内血流の解析

船本健一, 早瀬敏幸

日本可視化情報学会誌　29　(114)　20-26　2009/07
Publisher: 社団法人可視化情報学会
計測融合シミュレーションによる血流解析

船本健一, 早瀬敏幸

日本機械学会流体工学部門ニューズレター流れ　2009/04
539 Development of Poly (Vinyl Alcohol) Gel with in vivo Acoustic Properties

YAMASHITA Osamu, FUNAMOTO Kenichi, HAYASE Toshiyuki

2008　(21)　451-452　2009/01/22
Publisher: The Japan Society of Mechanical Engineers
326 Blood Flow Simulation Integrated with Ultrasonic Measurement 8th Report : Effect of Error in Ultrasonic Measurement

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

2008　(21)　353-354　2009/01/22
Publisher: The Japan Society of Mechanical Engineers
B406 Development of Material with Acoustic Property Close to Anatomy : Measurement System

YAMASHITA Osamu, FUNAMOTO Kenichi, HAYASE Toshiyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2008　(19)　141-142　2008/09/22
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B206 Numerical Experiment of MR-Measurement-Integrated Simulation of Unsteady Blood Flow in a Cerebral Aneurysm

FUNAMOTO Kenichi, SUZUKI Yoshitsugu, HAYASE Toshiyuki, KOSUGI Takashi, ISODA Haruo

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2008　(19)　52-53　2008/09/22
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
Visualization of blood flow field by ultrasonic-measurement-integrated simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, LIU Lei, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji

35　S254　2008/04/15

ISSN： 1346-1176
Carotid artery phantom using PVA-H (Poly vinyl alcohol hydro gel) for ultrasonic measurement and visualization

LIU Lei, HAYASE Toshiyuki, FUNAMOTO Kenichi, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Kouji

35　S311　2008/04/15

ISSN： 1346-1176
132 Ultrasonic-Measurement-Integrated Simulation on Laminar Flow in a Straight Tube : Three-Dimensional Analysis Using Non-Axisymmetric Feedback Law

FUNAMOTO Kenichi, LIU Lei, HAYASE Toshiyuki

2007　(20)　271-272　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
131 Ultrasonic-Measurement-Integrated Simulation on Laminar Flow in a Straight Tube : Axisymmetric Analysis Using Axisymmetric Feedback Law

LIU Lei, FUNAMOTO Kenichi, HAYASE Toshiyuki

2007　(20)　269-270　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
ナノバブルと高周波超音波による腫瘍内血管の三次元画像の構築(Construction of three-dimentional image of intratumoral vessel using high-frequency contrast-enhanced micro-ultrasound)

冨田典子, 堀江佐知子, 渡邊夕紀子, 船本健一, 早瀬敏幸, 大木宏介, 森川秀広, 小野栄夫, 森士朗, 小玉哲也

日本癌学会総会記事　66回　353-353　2007/08
Publisher: 日本癌学会
ISSN： 0546-0476
309 Blood Flow Simulation Integrated with Ultrasonic Measurement : 7^<th> Report: Effect of Time Resolution of Measurement

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

2006　(19)　68-69　2007/01/06
Publisher: The Japan Society of Mechanical Engineers
1306 Numerical Experiment of Ultrasonic-Measurement-Integrated Simulation for Three-Dimensional Unsteady Blood Flow(1)

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Fluids engineering conference ...　2006　"1306-a"　2006/10/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
223 Effect of Anisotropic Feedback Points Arrangement in Three-dimensional Ultrasonic-Measurement-Integrated Simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

2005　(18)　105-106　2006/01/12
Publisher: The Japan Society of Mechanical Engineers
B205 Blood Flow Simulation Integrated with Ultrasonic Measurement : 5^<th> Report: Reproduction of Three-dimensional Unsteady Blood Flow Field

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2005　(16)　137-138　2005/11/08
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
907 Evaluation of Effectiveness of Feedback Formulae in Three-dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow

Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

Fluids engineering conference ...　2005　139-139　2005/10/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
AM05-17-010 Effect of Feedback Points Arrangement on Accuracy of Three-dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow

Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

2005　226-226　2005
Publisher: 日本流体力学会

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We have developed Ultrasonic-Measurement-Integrated (UMI) simulation to obtain detailed and accurate information of blood flow field numerically for the diagnosis or treatment of aneurysms. In this methodology, feedback signals derived from the difference between Doppler velocities by measurement and computation are fed back to the numerical simulation. In this study, we investigate the effect of feedback point arrangement on the computational accuracy of three-dimensional UMI simulation by numerical analysis. The result of UMI simulation converges to the standard solution in the feedback domain and in some extent of the downstream region of the feedback domain. The computational accuracy is more improved as the increment of feedback point density, while the necessary computational time for convergence is unchanged.
Bio-Fluids

HAYASE Toshiyuki, FUNAMOTO Kenichi

Fluids engineering conference ...　2004　201-201　2004/11/24
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
Blood Flow Simulation Integrated with Ultrasonic Measurement 3^<rd> Report : Reproduction of Three-dimensional Blood Flow Field

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2004　(15)　113-114　2004/11/04
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
流体シミュレーションと融合した高度流体計測手法の開発 (第21回センシングフォーラム資料--センシング技術の新たな展開と融合) -- (セッション1A1 高機能流速・流量センシング--流体計測部会企画OS)

早瀬敏幸, 船本健一

センシングフォ-ラム資料　21　3-6　2004/09/14
Publisher: 〔計測自動制御学会〕
ISSN： 1343-7631
Ultrasonic-Measurement-Integrated Simulation for Blood Flows 2^<nd> Report : Reproduction of Blood Flow in Aorta

FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, YAMBE Tomoyuki, SAIJO Yoshifumi

2004　(16)　165-166　2004/01/21
Publisher: The Japan Society of Mechanical Engineers
B324 Study of Feedback Law for Ultrasonic-Measurement-Integrated Simulation of Blood Flow

FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, SAIJO Yoshifumi, YAMBE Tomoyuki

2004　538-539　2004
Publisher: 日本流体力学会

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In order to reproduce the blood velocity and pressure fields of the blood flow for an accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms, we integrate color Doppler ultrasonography and numerical simulation. We term this method as Ultrasonic-Measurement-Integrated (UMI) simulation. In the UMI simulation, feedback signals are added to the governing equations to compensate for the difference between computation and measurement. In this paper, we investigate effects of feedback law of the UMI simulation, such as feedback formulae, number and arrangement of monitoring points and the direction of ultrasonic beam for acquisition of Doppler velocity data, on the accuracy of the UMI simulation and computational time. It is revealed that the result of UMI simulation in the feedback domain rapidly converges to the standard solution, even with inevitably incorrect upstream boundary conditions.
Ultrasonic-Measurement-Integrated Simulation for Blood Flows : 1^<st> Report : Reduction of Error Originating from Upstream Boundary Condition

FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, YAMBE Tomoyuki, SAIJO Yoshifumi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　1　83-84　2003
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939

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Books and Other Publications 1

高度物理刺激と生体応答

Kenichi Funamoto

Yokendo co. ltd.　2017/08

ISBN: 9784842505626

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佐藤岳彦, 大橋俊朗, 川野聡恭, 白樫了編著

Presentations 332

ラグランジュ未定乗数法に基づく血管透過性の推定のためのデータ同化法（試行回数による誤差の収束性）

茂零音, 宮内優, 竹内伸太郎, 船本健一

日本機械学会九州学生会第54回学生員卒業研究発表講演会　2023/03/03
低酸素環境下の乳がんスフェロイドの動態解析

飯嶋雄太, 船本健一, 早瀬元, 吉野大輔

日本機械学会第33回バイオエンジニアリング講演会　2022/12/17
マイクロ流体デバイスの3次元培養系によるニワトリ胚肢芽間充織細胞の軟骨分化の観察

柳田翔平, 田村宏治, 船本健一

日本機械学会第33回バイオフロンティア講演会　2022/12/17
グルコース濃度と酸素濃度の変化に対する血管内皮細胞単層の応答の観察

曽根一輝, 廣瀬理美, 吉野大輔, 船本健一

日本機械学会第33回バイオフロンティア講演会　2022/12/18
細胞性粘菌の走気性の生化学的機構に関する研究

廣瀬理美, Jean-Paul Rieu, 船本健一

日本機械学会第33回バイオフロンティア講演会　2022/12/18
Clarification of the aerotaxis of Dictyostelium discoideum in microfluidic device with oxygen controllability

Satomi Hirose, Jean-Paul Rieu, Kenichi Funamoto

Lab-on-a-Chip and Microfluidics World Congress 2022　2022/12/14
Microfluidic platform for investigation of hypoxic responses of eukaryotic cells Invited

Kenichi Funamoto

The 6th FRIS-TFC Collaboration Event Workshop on Biosystems Design - From nanotechnology to microfluidics in biotechnology　2022/12/08
Cancer cell migration under oxygen concentration gradients

Satoshi Aratake, Zhouxing Su, Jean-Paul Rieu, Nicolas Aznar, Kenichi Funamoto

ELyT Workshop 2022　2022/11/18
Hypoxia triggers collective aerotactic spreading of eukaryotic cells

Nasser Ghazi, Satomi Hirose, Jean-Paul Rieu, Christophe Anjard, Kenichi Funamoto

ELyT Workshop 2022　2022/11/18
Brain-targeted mechanical intervention using passive head motion can be antihypertensive

Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Keisuke Shinohara, Takuya Kishi, Koji Tomiyasu, Toru Ogata, Hirotsugu Tsuchimochi, Shigeyoshi Saito, Kohzoh Yoshino, Kenichi Funamoto, Masahiro Shinohara, Motoshi Nagao, Yasuhiro Sawada

Angiotensin Gordon Research Conference 2022　2023/01
Three-dimensional culture of chick limb mesenchymal cells using microfluidic devices

Shohei Yanagita, Koji Tamura, Kenichi Funamoto

The 19th International Conference on Flow Dynamics (ICFD2022)　2022/11/09
Observation of neutrophil-like HL-60 cell motility under oxygen gradient

Masashi Tomita, Satomi Hirose, Kenichi Funamoto

The 19th International Conference on Flow Dynamics (ICFD2022)　2022/11/10
Microfluidic experiment about hypoxic responses of vascular endothelial cells under hyperglycemia

Kazuki Sone, Satomi Hirose, Daisuke Yoshino, Kenichi Funamoto

The 19th International Conference on Flow Dynamics (ICFD2022)　2022/11/10
Data assimilation method for estimating membrane permeability based on the Lagrange multiplier method: Effect of signal-to-noise ratio on estimation accuracy

Renon Shigeru, Suguru Miyauchi, Shintaro Takeuchi, Kenichi Funamoto

The 22nd International Symposium on Advanced Fluid Information (AFI-2022)　2022/11/10
Effects of pulsatile flow on endothelial permeability and cell motility

Kenichi Funamoto, Eugenia Corvera Poiré

The 22nd International Symposium on Advanced Fluid Information (AFI-2022)　2022/11/10
Visualization of extracellular vesicles transport across brain microvasculature in a human 3D blood-brain barrier chip

Yuka Sakamaki, Mai Inagaki, Momoko Sato, Miku Inai, Kenichi Funamoto, Masanori Tachikawa

The 22nd International Symposium on Advanced Fluid Information (AFI-2022)　2022/11/10
Numerical viscosity estimation considering inertial migration in plane Poiseuille suspension flow

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto

The 22nd International Symposium on Advanced Fluid Information (AFI-2022)　2022/11/11
Elucidation of a blood turbulence using electronic stethoscope

Hikaru Dalton Yukimura, Jota Sasaki, Masatsugu Hirano, Kenichi Funamoto, Katsuhito Yamasaki

The 22nd International Symposium on Advanced Fluid Information (AFI-2022)　2022/11/10
マイクロ流体デバイス上に構築した3次元ヒト脳血管網の特性解析

稲垣舞, 佐藤桃子, 船本健一, 立川正憲

第37回日本薬物動態学会　2022/11/10
マイクロ流体デバイスを用いた三次元ヒト血液脳関門の再構築と特性解析

立川正憲, 稲垣舞, 酒巻祐花, 佐藤桃子, 船本健一

第44回神経組織培養研究会　2022/11/06
マイクロ流体デバイスを用いた3次元ヒト脳血管網の再構築

今井健, 稲垣舞, 佐藤桃子, 船本健一, 立川正憲

第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会　2022/11/05
Brain-targeted mechanical intervention using passive head motion can have an antihypertensive effect

Yasuhiro Sawada, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Keisuke Shinohara, Takuya Kishi, Ayumu Konno, Hirokazu Hirai, Makoto Ayaori, Hirohiko Inanami, Koji Tomiyasu, Toru Ogata, Hirotsugu Tsuchimochi, Shinya Sato, Shigeyoshi Saito, Kohzoh Yoshino, Kenichi Funamoto, Hiroki Ochi, Masahiro Shinohara, Motoshi Nagao

The Resuscitation Science Symposium 2022　2022/10/30
Brain- Targeted Mechanical Intervention Using Passive Head Motion Can Have an Antihypertensive Effect

Yasuhiro Sawada, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Keisuke Shinohara, Takuya Kishi, Ayumu Konno, Hirokazu Hirai, Makoto Ayaori, Hirohiko Inanami, Koji Tomiyasu, Toru Ogata, Hirotsugu Tsuchimochi, Shinya Sato, Shigeyoshi Saito, Kohzoh Yoshino, Kenichi Funamoto, Hiroki Ochi, Masahiro Shinohara, Motoshi Nagao

CIRCULATION　2022/11
Data assimilation method for estimating membrane permeability based on the Langrange multiplier method: formulation and fundamental examination

Suguru Miyauchi, Shintaro Takeuchi, Kenichi Funamoto

15th World Congress on Computational Mechanics (WCCM-XV) 8th Asian Pacific Congress on Computational Mechanics (APCOM-VIII)　2022
細胞性粘菌の走気性の特性の解析

廣瀬理美, Jean-Paul Rieu, 船本健一

日本機械学会第34回バイオエンジニアリング講演会　2022/06/25
マイクロ流体デバイスを用いた三次元ヒト微小血管網モデルの構築と胎盤由来細胞外小胞の動態可視化

酒巻祐花, 稲垣舞, 佐藤桃子, 中野瑛介, 船本健一, 立川正憲

日本薬剤学会第37年会　2022/05/27
マイクロ流体デバイスを用いた三次元ヒト脳微小血管網の構築

佐藤桃子, 稲垣舞, 酒巻祐花, 船本健一, 立川正憲

日本薬学会第142年会　2022/03/26
生理学的レベルの酸素濃度勾配下におけるがん細胞の動態の観察

荒武聖, 吉野大輔, 船本健一

日本機械学会第32回バイオフロンティア講演会　2022/01/13
低酸素負荷時のエンドサイトーシスによるVE-カドヘリンの内在化の評価

曽根一輝, 廣瀬理美, 吉野大輔, 船本健一

日本機械学会第32回バイオフロンティア講演会　2022/01/13
流れと低酸素負荷による血管内皮細胞の遊走速度の増加と低酸素誘導因子の核内移行

菅原竜志, 船本健一

日本機械学会第32回バイオフロンティア講演会　2022/01/12
繰り返し低酸素負荷による3次元微小血管網モデルの物質透過性の亢進

二階堂正隆, 大﨑達哉, 船本健一

日本機械学会第32回バイオフロンティア講演会　2022/01/12
大動脈二尖弁における左心室内血流場の変化に関する数値解析

津田晋吾, 宮内優, 船本健一

日本機械学会第32回バイオフロンティア講演会　2022/01/12
Migration characteristics of Dictyostelium;discoideum depending on oxygen environment

Satomi Hirose, Jean-Paul Rieu, Kenichi Funamoto

The 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021)　2021/12/04
Reconstruction of 3D human brain microvasculature on a chip using brain endothelial cells, astrocytes and pericytes

Momoko Sato, Mai Inagaki, Yuka Sakamaki, Kenichi Funamoto, Masanori Tachikawa

Proceedings of the 18th International Conference on Flow Dynamics (ICFD2021)　2021/10
Comparison of permeability of 3D microvascular network model under controlled oxygen concentration

Masataka Nikaido, Tatsuya Osaki, Kenichi Funamoto

Proceedings of the 18th International Conference on Flow Dynamics (ICFD2021)　2021/10
Evaluation of migration speed of cancer cells by different types of matrices using microfluidic devices

Satoshi Aratake, Kenichi Funamoto

Proceedings of the 18th International Conference on Flow Dynamics (ICFD2021)　2021/10
Oxygen gradient under severe hypoxia changes Dictyostelium migration directionality

Satomi Hirose, Jean-Paul Rieu, Christophe Anjard, Olivier Cochet-Escartin, Kenichi Funamoto

Proceedings of the 18th International Conference on Flow Dynamics (ICFD2021)　2021/10
Evaluation of PAK1 localization in vascular endothelial cells by hypoxic stresses using microfluidic devices

Kazuki Sone, Satomi Hirose, Daisuke Yoshino, Kenichi Funamoto

Proceedings of the 18th International Conference on Flow Dynamics (ICFD2021)　2021/10
Enhanced Collective migration of endothelial cells in the early stage of exposure to low shear stress

Ryuji Sugahara, Kenichi Funamoto

Proceedings of the 18th International Conference on Flow Dynamics (ICFD2021)　2021/10
Modelling self-organization by oxygen with reaction-diffusion models

Olivier Cochet-Escartin, Mete Demircigil, Satomi Hirose, Vincent Calvez, Kenichi Funamoto, Christophe Anjard, Jean-Paul Rieu

Proceedings of the 21st International Symposium on Advanced Fluid Information (AFI-2021)　2021/10
Science of ultrafine droplet;high speed impact

Takehiko Sato, Masao Watanabe, Takeru Yano, Yuka Iga, Kazumichi Kobayashi, Atsuki Komiya, Hidemasa Takana, Kiyonobu Ohtani, Junnosuke Okajima, Kenichi Funamoto, Yunchen Xiao, Tomoki Nakajima, Siwei Liu

Proceedings of the 21st International Symposium on Advanced Fluid Information (AFI-2021)　2021/10
Numerical analysis of a blood flow in the left ventricle-aorta system

Suguru Miyauchi, Shuta Kosaka, Toshiyuki Hayase, Kenichi Funamoto

Proceedings of the 21st International Symposium on Advanced Fluid Information (AFI-2021)　2021/10
Reconstruction of perfusable human 3D microvasculature on a chip as an evaluation model of cancer cell extravasation and drug transport

Yuka Sakamaki, Mai Inagaki, Momoko Sato, Kenichi Funamoto, Masanori Tachikawa

Proceedings of the 21st International Symposium on Advanced Fluid Information (AFI-2021)　2021/10
Effects of shear stress on endothelial cell motility

Kenichi Funamoto, Eugenia Corvera Poiré

Proceedings of the 21st International Symposium on Advanced Fluid Information (AFI-2021)　2021/10
Numerical study on the inertial migration and effective viscosity in pressure-driven suspension flows including elliptical particles

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto

Proceedings of the 21st International Symposium on Advanced Fluid Information (AFI-2021)　2021/10
Elucidation of a blood turbulence using electronic stethoscope

Masatsugu Hirano, Hikaru Dalton Yukimura, Katsuhito Yamasaki, Kenichi Funamoto

Proceedings of the 21st International Symposium on Advanced Fluid Information (AFI-2021)　2021/10
酸素濃度依存性を有する血管内皮細胞の遊走におけるPAK1の活性化の評価

曽根一輝, 廣瀬理美, 吉野大輔, 船本健一

日本機械学会第33回バイオエンジニアリング講演会　2021/06/25
低酸素負荷による細胞性粘菌の運動性増進に関する評価

廣瀬理美, Jean-Paul Rieu, 船本健一

日本機械学会第33回バイオエンジニアリング講演会　2021/06/25
Reduced oxygen availability triggers aerotaxis and aerokinesis of Dictyostelium International-coauthorship

Satomi Hirose, Olivier Cochet-Escartin, Christophe Anjard, Jean-Paul Rieu, Kenichi Funamoto

Proceedings of the LyonSE&N & ELyT Global Workshop 2021　2021/06
マイクロ流体デバイスを用いた灌流性を有する三次元ヒト微小血管網の再構築

酒巻祐花, 稲垣舞, 佐藤桃子, 船本健一, 立川正憲

日本薬剤学会第36年会　2021/05/13
酸素濃度制御下の3次元微小血管網モデルの物質透過性の評価

二階堂正隆, 大﨑達哉, 船本健一

日本機械学会第31回バイオフロンティア講演会　2020/12/12
マイクロ流体デバイスによる酸素濃度勾配下の細胞性粘菌の運動解析

廣瀬理美, Jean-Paul Rieu, 船本健一

日本機械学会第31回バイオフロンティア講演会　2020/12/13
乳腺がん細胞の低酸素感知と遊走速度の変化

荒武聖, 吉野大輔, 船本健一

日本機械学会第31回バイオフロンティア講演会　2020/12/13
低酸素負荷と流れ負荷時の血管内皮細胞の集団的遊走の評価

高橋直之, 吉野大輔, 船本健一

日本機械学会第31回バイオフロンティア講演会　2020/12/13
Dynamics observation of vascular microenvironment by using microfluidic device with controllability of oxygen concentration Invited

Kenichi Funamoto

The 43rd Annual Meeting of the Molecular Biology Society of Japan　2020/12/03
Observation and analysis of cellular dynamics by using organ-on-a-chip Invited

Kenichi Funamoto

2020/11/18
3D human blood-brain barrier chip for central nervous system drug development

Momoko Sato, Yuuka Sakamaki, Mai Inagaki, Kenichi Funamoto, Masanori Tachikawa

The 20th International Symposium on Advanced Fluid Information (AFI-2020)　2020/10/28
Novel experimental-computational research framework for in-depth understanding of cancer mechanobiology

Ryo Torii, Kenichi Funamoto

The 20th International Symposium on Advanced Fluid Information (AFI-2020)　2020/10/28
Mass transport analysis in a tumor microenvironment using finite element method

Masataka Nikaido, Suguru Miyauchi, Kenichi Funamoto, Toshiyuki Hayase

The 17th International Conference on Flow Dynamics (ICFD2020)　2020/10/30
Measurement of oxygen;ension in microfluidic device by using oxygen-sensing film

Naoyuki Takahashi, Satomi Hirose, Jean-Paul Rieu, Kenichi Funamoto

The 17th International Conference on Flow Dynamics (ICFD2020)　2020/10/30
Evaluation of Dictyostelium migration under oxygen concentration gradient

Satomi Hirose, Jean-Paul Rieu, Kenichi Funamoto

The 17th International Conference on Flow Dynamics (ICFD2020)　2020/10/30
Changes of migration speed of breast cancer cells by oxygen sensing

Satoshi Aratake, Daisuke Yoshino, Kenichi Funamoto

The 17th International Conference on Flow Dynamics (ICFD2020)　2020/10/30
Fundamental study of the blood flow field in the left ventricle with aortic regurgitation

Ryuji Sugawara, Suguru Miyauchi, Toshiyuki Hayase, Kenichi Funamoto

The 17th International Conference on Flow Dynamics (ICFD2020)　2020/10/30
Experimental study on the radial particle distributions of neutrally buoyant spheres in a dilute suspension flow through a circular microchannel

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Miho Tanaka, Mitsuru Tanaka, Shigeru Murata, Suguru Miyauchi, Toshiyuki Hayase

The 20th International Symposium on Advanced Fluid Information (AFI-2020)　2020/10/30
Endothelial cell migration under oscillatory flow

Kenichi Funamoto, Eugenia Corvera Poiré

The 20th International Symposium on Advanced Fluid Information (AFI-2020)　2020/10/28
Hypoxia triggers collective aerotactic migration in Dictyostelium discoideum

Olivier Cochet-Escartin, Satomi Hirose, Kenichi. Funamoto, Christophe Anjard, Jean-Paul Rieu

The 20th International Symposium on Advanced Fluid Information (AFI-2020)　2020/10/30
酸素に依存する細胞運動の機序解明を目的とした細胞性粘菌の走気性の観察

廣瀬理美, Jean-Paul Rieu, 船本健一

生体医工学シンポジウム2020　2020/09/19
Reduced oxygen availability triggers aerotactic migration of Dictyostelium

Jean-Paul Rieu, Kenichi Funamoto

LyonSEN – ELyT Workshop 2020　2020/02/18
Mechanism through which hydrostatic pressure promotes cell cycle in vascular endothelial cells

Satomi Hirose, Kenichi Funamoto, Daisuke Yoshino

2019/12/21
Breast cancer cell migration under oxygen gradient

Kenichi Funamoto, Rei Koens, Yugo Tabata, Daisuke Yoshino

2019/12/21
Oxygen-dependent migration of breast cancer cell is altered by cell-cell interaction with vascular endothelial cells

Kenichi Funamoto, Rei Koens, Yugo Tabata, Daisuke Yoshino

The 17th international conference on biomedical engineering (ICBME 2019)　2019/12/11
Increased hydrostatic pressure affects vascular endothelial cell behavior

Satomi Hirose, Kenichi Funamoto, Daisuke Yoshino

The 17th international conference on biomedical engineering (ICBME 2019)　2019/12/09
Controlled oxygen tension regulates vascular endothelial cell migration through p21-activated kinase signaling

Yugo Tabata, Naoyuki Takahashi, Daisuke Yoshino, Kenichi Funamoto

The 17th international conference on biomedical engineering (ICBME 2019)　2019/12/10
Vascular endothelial responses to fluid flow under hypoxic condition

Naoyuki Takahashi, Yugo Tabata, Satomi Hirose, Kiyoe Funamoto, Daisuke Yoshino, Kenichi Funamoto

The 17th international conference on biomedical engineering (ICBME 2019)　2019/12/11
Microfluidic device for reproduction of in vivo microenvironment with three-dimensional vascular structure Invited

Kenichi Funamoto

The 34th Annual Meeting of the Japanese Society for the Study of Xenobiotics　2019/12/10
Investigation of oxygen-dependent vascular endothelial cell migration using microfluidic device

Yugo Tabata, Naoyuki Takahashi, Daisuke Yoshino, Kenichi Funamoto

The 16th International Conference on Flow Dynamics (ICFD2019)　2019/11/08
A method to control oxygen tension in microfluidic device for reproducing vascular microenvironment

Naoyuki Takahashi, Yugo Tabata, Daisuke Yoshino, Kenichi Funamoto

The 16th International Conference on Flow Dynamics (ICFD2019)　2019/11/08
Measurement of particle concentration profiles of a dilute suspension in different Reynolds number conditions

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Mitsuru Tanaka, Shigeru Murata, Suguru Miyauchi, Toshiyuki Hayase

The 19th International Symposium on Advanced Fluid Information (AFI-2019)　2019/11/07
高血圧様の静水圧刺激に対する血管内皮細胞の応答

廣瀬理美, 船本健一, 吉野大輔

日本機械学会第30回バイオフロンティア講演会　2019/07/20
血管内低酸素環境模擬チップによる血管内皮細胞の形態変化の評価

高橋直之, 田端優吾, 廣瀬理美, 船本聖絵, 吉野大輔, 船本健一

日本機械学会第30回バイオフロンティア講演会　2019/07/19
低酸素負荷による血管内皮細胞の接着結合と遊走の変化

田端優吾, 吉野大輔, 船本聖絵, 船本健一

日本機械学会第30回バイオフロンティア講演会　2019/07/19
がん微小環境チップによる酸素濃度制御下の細胞外マトリクスの変化の観察

船本健一, 吉野大輔

日本機械学会第31回バイオエンジニアリング講演会　2018/12/15
Breast cancer cell migration under controlled oxygen tensions International-presentation

Rei Koens, Yugo Tabata, Daisuke Yoshino, Kenichi Funamoto

The 15th International Conference on Flow Dynamics (ICFD2018)　2018/11/08
Influence of hypoxic environment on vascular endothelial cell migration International-presentation

Yugo Tabata, Daisuke Yoshino, Kiyoe Funamoto, Rei Koens, Kenichi Funamoto

The 15th International Conference on Flow Dynamics (ICFD2018)　2018/11/08
Numerical and experimental studies on non-Newtonian rheology of a suspension International-presentation

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Suguru Miyauchi, Toshiyuki Hayase

The 18th International Symposium on Advanced Fluid Information (AFI-2018)　2018/11/08
マイクロ流体デバイスを用いた酸素制御下の血管内皮細胞単層の遊走の評価

田端優吾, 吉野大輔, 船本聖絵, コーエンズ礼, 船本健一

日本機械学会第29回バイオフロンティア講演会　2018/10/25
乳腺がん細胞の遊走と増殖の酸素依存性

コーエンズ礼, 田端優吾, 吉野大輔, Roger D. Kamm, 船本健一

日本機械学会第29回バイオフロンティア講演会　2018/10/25
地球の裏側で Invited

船本健一

日本機械学会第29回バイオフロンティア講演会　2018/10/24
A loss of vascular endothelial barrier function by hypoxic exposure International-presentation

Kenichi Funamoto, Yugo Tabata, Rei Koens, Daisuke Yoshino

World Congress of Biomechanics 2018 (WCB2018)　2018/07/09
Initial response of cell-cell junction in endothelial monolayer to hypoxic exposure

FUNAMOTO Kenichi, YOSHINO Daisuke, NAKAYAMA Masafumi

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2018
低酸素ストレスに対する血管内皮細胞単層の細胞間結合の初期応答

船本健一, 吉野大輔, 中山勝文

日本機械学会第30回バイオエンジニアリング講演会　2017/12/14
Microfluidic device for co-culture under controlled oxygen tension International-presentation

Kenichi Funamoto, Daisuke Yoshino

The 3rd International Symposium on Mechanobiology (ISMB2017)　2017/12/11
Estimation of viscosity profiles of semidilute suspensions by computational and experimental studies International-presentation

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Toshiyuki Hayase

The 17th International Symposium on Advanced Fluid Information (AFI-2017)　2017/11/02
生体内低酸素環境を再現するマイクロ流体デバイスの酸素濃度制御性能の向上

コーエンズ礼, 田端優吾, 吉野大輔, Roger D. Kamm, 船本健一

日本機械学会第28回バイオフロンティア講演会　2017/10/29
Microfluidic experiments of cellular responses to hypoxia International-presentation Invited

臺灣人才躍昇計畫 2017系列講座(三)　2017/09/08
The neurophysiology of brain sparing International-presentation

Clarissa, L. Velayo, Takuya Ito, YuPeng Dong, Kenichi Funamono, Kiyoe Funamono, Keita Iida, Miyuki Endo, Rika Sugibayashi, Nobuo Yaegashi, Yoshitaka Kimura

The 44th Annual Meeting Fetal and Neonatal Physiological Society　2017/09/04
Excess retinoic acid to pregnant mouse increases the risk of Long QT syndrome for the fetal heart International-presentation

Kiyoe Funamoto, Motoyoshi Kawataki, Kana Nakanishi, Chihiro Yoshida, Kenichi Funamoto, YuPeng Dong, Takuya Ito, Naoaki Sato, Yoshitaka Kimura

The Joint Meeting of the German and Japanese Societies of Developmental Biologists　2017/03/17
低酸素負荷による血管内皮細胞単層の物質透過性と接着結合の変化

船本健一, 吉野大輔, 松原健人, 船本聖絵, 木村芳孝, Roger D. Kamm

日本機械学会第29回バイオエンジニアリング講演会　2017/01/20
Microfluidic device for investigation of cellular responses to heterogeneity of oxygen tension International-presentation

Kenichi Funamoto, Roger D. Kamm

The 16th International Conference on Biomedical Engineering (ICBME 2016)　2016/12/07
Microfluidic experiments of cellular responses to hypoxia International-presentation

Kenichi Funamoto

The 13th International Conference on Flow Dynamics (ICFD2016)　2016/10/11
Preliminary study for fluid dynamic effects of upstream bifurcation and bend on blood flow simulation in cerebral aneurysm International-presentation

Daichi Suzuki, Kenichi Funamoto, Shin-ichiro Sugiyama, Toshiyuki Hayase, Suguru Miyauchi, Teiji Tominaga

The 16th International Conference on Biomedical Engineering (ICBME 2016)　2016/10/11
Analysis of an autonomic nervous system of mouse fetus with congenital heart defect International-presentation

Kiyoe Funamoto, Rika Sugibayashi, Kenichi Funamoto, Kana Nakanishi, Takuya Ito, Motoyoshi Kawataki, Toshiyuki Hayase, Yoshitaka Kimura

The 16th International Symposium on Advanced Fluid Information (AFI-2016)　2016/10/11
Computational and experimental studies on the blood cells behavior in microcirculation International-presentation

Tomohiro Fukui, Misa Kawaguchi, Atsuhide Kitagawa, Kenichi Funamoto, Toshiyuki Hayase

The 16th International Symposium on Advanced Fluid Information (AFI-2016)　2016/10/11
拍動に伴う血管変形を考慮した2次元超音波計測融合血流解析システム

原田大輔, 早瀬敏幸, 宮内優, 井上浩介, 門脇弘子, 船本健一, 島崎正, 地挽隆夫, 見山広二

日本超音波医学会第89回学術集会　2016/05/27
Investigation of permeability of endothelial cell monolayer by using microfluidic device with controllability of oxygen tension

日本機械学会第28回バイオエンジニアリング講演会　2016/01/10
静水圧負荷による一過性のERK活性を介した血管新生の促進

吉野大輔, 船本健一, 佐藤正明, Lim Chwee Teck

日本機械学会第28回バイオエンジニアリング講演会　2016/01/09
Study of Permeability Changes of Endothelial Cell Monolayer Exposed to Hypoxia International-presentation

Kento Matsubara, Kenichi Funamoto, Ioannis K. Zervantonakis, Kiyoe Funamoto, Takuya Ito, Yoshitaka Kimura, Toshiyuki Hayase, Roger D. Kamm

The 12th International Conference on Flow Dynamics (ICFD2015)　2015/10/29
Determination of Optimum Feedback Gain of Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis System International-presentation

Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Suguru Miyauchi, Kosuke Inoue, Tadashi Shimazaki, Takao Jibiki, Koji Miyama

The 12th International Conference on Flow Dynamics (ICFD2015)　2015/10/29
Fundamental Study of Interaction between Erythrocyte and Endothelial Cell under Inclined Centrifugal Force (Physical Explanation of Interaction Model) International-presentation

Akira Yatsuyagagi, Toshiyuki Hayase, Suguru Miyauchi, Kenichi Funamoto, Kosuke Inoue, Atsushi Shirai, Luca Brandt

The 12th International Conference on Flow Dynamics (ICFD2015)　2015/10/28
Numerical Analysis of Ultrasound Scattering Property of Medium Mimicking Blood (Influence of Ultrasound Frequency) International-presentation

Yoshiki Chiba, Toshiyuki Hayase, Suguru Miyauchi, Kenichi Funamoto

The 12th International Conference on Flow Dynamics (ICFD2015)　2015/10/28
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound International-presentation

Rika Sugibayashi, Takuya Ito, Kenichi Funamoto, Toshiyuki Hayase, Yoshitaka Kimura

The 15th International Symposium on Advanced Fluid Information (AFI-2015)　2015/10/28
Investigation of Inlet Position in Hemodynamic Analysis of a Cerebral Aneurysm International-presentation

Daichi Suzuki, Kenichi Funamoto, Shin-ichiro Sugiyama, Toshiyuki Hayase, Suguru Miyauchi, Teiji Tominaga

The 12th International Conference on Flow Dynamics (ICFD2015)　2015/10/27
マイクロ流体デバイスによる低酸素下の血管内皮細胞の物質透過性の計測

松原健人, 船本健一, Ioannis Zervantonakis, 船本聖絵, 伊藤拓哉, 正宗淳, 木村芳孝, 早瀬敏幸, Roger Kamm

日本機械学会第26回バイオフロンティア講演会　2015/10/02
2次元超音波計測融合血流解析における上流端流速推定手法の実血管形状による検証

門脇弘子, 早瀬敏幸, 船本健一, 宮内優, 谷口信行

日本流体力学会年会2015　2015/09/27
Effect of Speckle Noise in Ultrasonic Measurement on Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis International-presentation

Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Suguru Miyauchi, Kosuke Inoue, Tadashi Shimazaki, Takao Jibiki, Koji Miyama

The International Conference on Biotechnology and Bioengineering　2015/07/14
2次元超音波計測融合血流解析システムにおける最適フィードバックゲインの決定

門脇弘子, 早瀬敏幸, 船本健一, 井上浩介, 島崎正, 地挽隆夫, 見山広二

日本超音波医学会第88回学術集会　2015/05/22
Measurements of Blood Flow and Blood Pressure under Different Indoor Temperature and Body Postural Conditions, and Development of a New Human Simulation Model International-presentation

Hiroto Sakamoto, Yuki Chiba, Toshiyuki Hayase, Kenichi Funamoto, Yoshifumi Saijo, Tomonobu Goto

Healthy Buildings Europe 2015　2015/05/19
2次元超音波計測融合血流解析システムにおける超音波計測ノイズと解析精度に関する実験的検討

門脇弘子, 早瀬敏幸, 船本健一, 井上浩介, 島崎正, 地挽隆夫, 見山広二

流体科学研究所・統計数理研究所合同ワークショップ　2015/03/26
2次元超音波計測融合血流解析システムの有用性の検証

船本健一, 早瀬敏幸, 曾根周作, 門脇弘子, 島崎正, 地挽隆夫, 見山広二

流体科学研究所・統計数理研究所合同ワークショップ　2015/03/26
MR画像データに基づく左心室内血流場の数値解析（非定常3D心室モデルの構築）

山田智美, 早瀬敏幸, 船本健一

日本機械学会東北支部第50期総会・講演会　2015/03/13
Analysis of High Reynolds Number Flow Behind a Square Cylinder by Hybrid Wind Tunnel (Reproduction of Turbulent Velocity Fluctuations) International-presentation

Jumpei Okutani, Toshiyuki Hayase, Kosuke Inoue, Shusaku Sone, Kenichi Funamoto

2015 Annual ELyT Workshop　2015/02/19
脳動脈瘤内の血流の数値解析における上流端の設定法の検討

鈴木大地, 船本健一, 杉山慎一郎, 早瀬敏幸, 冨永悌二

日本機械学会第27回バイオエンジニアリング講演会　2015/01/10
3次元非定常の超音波計測融合血流解析における圧力場の再現に関する検討

船本健一, 早瀬敏幸

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
酸素濃度依存の細胞応答観察のためのマイクロ流体デバイスの開発

藤高直也, 福島修一郎, 船本健一, 橋本守, 荒木勉

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
低酸素マイクロ流体デバイスを用いた血管内皮細胞単層の物質透過性の評価

松原健人, 船本健一, Ioannis Zervantonakis, 船本聖絵, 伊藤拓哉, 正宗淳, 木村芳孝, 早瀬敏幸, Roger Kamm

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
傾斜遠心力場における赤血球と内皮細胞との力学的相互作用の解明（相互作用モデルの物理的解釈）

八柳暁, 早瀬敏幸, 船本健一, 井上浩介, 白井敦

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
傾斜遠心顕微鏡による内皮細胞上の赤血球の摩擦特性の計測（傾斜遠心力の垂直成分の影響）

井上浩介, 早瀬敏幸, 船本健一, 白井敦

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
希釈した血液を模擬した媒質における超音波の散乱特性に関する数値解析（超音波の周波数の影響）

千葉吉規, 早瀬敏幸, 船本健一

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
2次元超音波計測融合シミュレーションシステムにおける解析精度の実験的検証

門脇弘子, 早瀬敏幸, 船本健一, 井上浩介, 島崎正, 地挽隆夫, 見山広二

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
超音波計測と計測融合シミュレーションによる血圧場と血流場の同時解析システム

曾根周作, 早瀬敏幸, 船本健一, 白井敦

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
2次元超音波計測融合血流解析システムによる頸動脈内の血流解析

第14回日本流体力学会中四国・九州支部講演会　2014/12/14
2次元超音波計測融合シミュレーションによる頸動脈分岐部の血流解析

計測自動制御学会東北支部50周年記念学術講演会　2014/12/11
酸素濃度制御マイクロ流体デバイスを用いた細胞実験

第18回酸素ダイナミクス研究会　2014/11/29
Analysis of High Reynolds Number Flow behind a Square Cylinder by Hybrid Wind Tunnel (Improvement of Critical Gain of Instability for Pressure Feedback) International-presentation

The 11th International Conference on Flow Dynamics (ICFD2014)　2014/10/10
Application of MR-Measurement-Integrated Hemodynamic Simulation to Cerebrovascular Diseases International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Elucidation of Mechanisms of the Frictional Characteristics of Erythrocytes under Inclined Centrifugal Force International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Evaluation of Permeability of Endothelial Cell Monolayer under Controlled Oxygen Tension International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Investigation on Advanced Medical Ultrasound Imaging Technology International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Observation of Hypoxia Cellular Response by Using Microfluidic Devices International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Fundamental Study of Interaction between Erythrocyte and Endothelial Cell under Inclined Centrifugal Force (Reproduction of Friction Characteristics by Numerical Analysis Using Simple Interaction Model) International-presentation

Eleventh International Conference on Flow Dynamics (ICFD2014)　2014/10/08
光電容積脈波計測と超音波計測融合シミュレーションによる頸動脈内の血圧と血流場の同時解析

日本流体力学会年会2014　2014/09/17
超音波計測融合シミュレーションにおける血流量推定手法の有効性の検証

日本流体力学会年会2014　2014/09/17
Studies on the basic technology of “Sono-cytometry”

Yosuke Komatsu, Ryo Nagaoka, Kenichi Funamoto, Toshiyuki Hayase, Nobuo Masauzi, Hiroshi Kanai, Yoshifumi Saijo

Transactions of Japanese Society for Medical and Biological Engineering　2014/08/17
“Sonocytometry” - Novel Diagnostic Method of Ultrasonic Differentiation of Cells in Blood Flow International-presentation

The 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’14)　2014/08
Simultaneous Analysis System for Blood Pressure and Flow Using Ultrasonic-Measurement-Integrated Simulation International-presentation

7th World Congress of Biomechanics　2014/07/11
Observation of Extracellular Collagen Remodeling by Second-Harmonic-Generation Microscopy International-presentation

The 7th World Congress of Biomechanics　2014/07/06
Twinkling Sign機序解明のための超音波照射による微粒子挙動の光学観察

日本超音波医学会第87回学術集会　2014/05/10
ソノサイトメトリーの基盤技術の検討

日本超音波医学会第87回学術集会　2014/05/09
光電脈波計測と超音波計測融合解析による血圧血流同時計測システムによるWI解析

日本超音波医学会第87回学術集会　2014/05/09
超音波計測融合シミュレーションにおける血流量推定精度の向上

日本超音波医学会第87回学術集会　2014/05/09
超音波計測融合シミュレーションにおける血流量推定精度の向上

門脇弘子, 早瀬敏幸, 船本健一, 曾根周作, 島崎正, 地挽隆夫, 見山広二, 劉磊

超音波医学　2014/04
光電脈派計測と超音波計測融合解析による血圧血流同時計測システムによるWI解析

曾根周作, 早瀬敏幸, 船本健一, 白井敦

超音波医学　2014/04
ハイブリッド風洞による角柱後流の高レイノルズ数流れ解析（圧力フィードバックにおける不安定化臨界ゲインの改善）

日本機械学会東北支部第49期総会・講演会　2014/03/14
傾斜遠心力場における赤血球と内皮細胞との力学的相互作用の解明（赤血球とグリコカリックスの相互作用モデルを用いた数値解析による摩擦特性の再現）

日本機械学会東北支部第49期総会・講演会　2014/03/14
光電脈波計測と超音波計測融合シミュレーションによる血圧と血流の同時計測システムの開発（開発システムによるWave Intensityの評価）

日本機械学会第26回バイオエンジニアリング講演会　2014/01/12
小動物用超音波計測連成解析システムによる３次元血管形状抽出と血流解析の精度検証

日本機械学会第26回バイオエンジニアリング講演会　2014/01/12
総頸動脈内血流の2次元超音波計測融合シミュレーションにおける2次元断面流量の軸方向変化の影響

日本機械学会第26回バイオエンジニアリング講演会　2014/01/12
超音波計測融合シミュレーションにおける血流量推定の評価関数に関する考察

日本機械学会第26回バイオエンジニアリング講演会　2014/01/12
脳動脈瘤の壁面性状と血行力学パラメータの比較

日本機械学会第26回バイオエンジニアリング講演会　2014/01/11
微小流体デバイス内における血管新生過程の基質再構築

日本機械学会第26回バイオエンジニアリング講演会　2014/01/11
2B47 Consideration on the evaluation function of blood flow rate estimation in ultrasonic-measurement-integrated simulation

KADOWAKI Hiroko, HAYASE Toshiyuki, FUNAMOTO Kenichi, SONE Shusaku, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji, LIU Lei

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2014
2B26 Development of Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation : Evaluation of Wave Intensity Using Developed System

Shusaku SONE, Toshiyuki HAYASE, Kenichi FUNAMOTO, Atsushi SHIRAI

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2014
107 Analysis of High Reynolds Number Flow Behind a Square Cylinder by Hybrid Wind Tunnel : Improvement of Critical Gain of Instability for Pressure Feedback

Jumpei OKUTANI, Toshiyuki HAYASE, Kosuke INOUE, Shusaku SONE, Kenichi FUNAMOTO

The Proceedings of Conference of Tohoku Branch　2014
Hemodynamic analysis of intracranial aneurysms with atherosclerosis

Shinichiro Sugiyama, K. Funamoto, T. Nakayama, K. Niizuma, T. Tominaga

IFMBE Proceedings　2014
Effects of Time-Varying Feedback Signals on Pressure Field in Ultrasonic-Measurement-Integrated Simulation of Pulsatile Blood Flow International-presentation

The 3rd International Conference on Computational and Mathematical Biomedical Engineering (CMBE13)　2013/12/17
低酸素マイクロ流体デバイスの開発

第11回がんとハイポキシア研究会　2013/12/13
Evaluation by High-Frequency Ultrasound B-Mode Imaging of Cerebral Hemorrhage in Mouse Fetal Brain Resulting from Ischemia/Reperfusion International-presentation

The 15th International Conference on Biomedical Engineering (ICBME 2013)　2013/12/07
Validation of blood vessel geometry reconstruction and of blood flow analysis by ultrasonic-measurement-integrated flow-structure interaction simulation system for small animals International-presentation

The 15th International Conference on Biomedical Engineering　2013/12/07
Comparison of Hemodynamic Parameters and Wall Condition of Cerebral Aneurysm International-presentation

The 15th International Conference on Biomedical Engineering (ICBME 2013)　2013/12/06
Hemodynamic Analysis of Intracranial Aneurysms with Atherosclerosis International-presentation

The 15th International Conference on Biomedical Engineering (ICBME 2013)　2013/12/06
The Effect of Axial Variation of the Plane Flow Rate on Two-Dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow in a Common Carotid Artery International-presentation

The 15th International Conference on Biomedical Engineering (ICBME 2013)　2013/12/06
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound International-presentation

The 13th International Symposium on Advanced Fluid Information (AFI-2013)　2013/11/26
Development of a Microfluidic Device for a Three-Dimensional Cell Culture under a Controlled Hypoxic Environment International-presentation

The 13th International Symposium on Advanced Fluid Information (AFI-2013)　2013/11/26
Effects of Temporal and Spatial Oxygen Heterogeneity on Cell Processes International-presentation

The 13th International Symposium on Advanced Fluid Information (AFI-2013)　2013/11/26
Evaluation of Intracranial Aneurysm Rupture Using MR-Measurement-Integrated Simulation International-presentation

The 13th International Symposium on Advanced Fluid Information (AFI-2013)　2013/11/26
In-Depth Investigation of Twinkling Sign: Optical Observation of Ultrasound Radiation Force Driven Oscillation of Glass Particle International-presentation

The 13th International Symposium on Advanced Fluid Information (AFI-2013)　2013/11/26
Numerical Simulation of Ultrasound Imaging for Detection of Microcalcification in Soft Tissue International-presentation

The 13th International Symposium on Advanced Fluid Information (AFI-2013)　2013/11/26
Observation of Hypoxia Cellular Response by Using Microfluidic Devices International-presentation

The 13th International Symposium on Advanced Fluid Information (AFI-2013)　2013/11/26
Improvement of Simultaneous Analysis System for Blood Pressure and Flow Velocity Using Photoplethymography and Ultrasonic-Measurement-Integrated Simulation International-presentation

7th East Asian Consortium on Biomedical Engineering　2013/11/18
Consideration on the Evaluation Function of Blood Flow Rate Estimation in Ultrasonic-Measurement-Integrated Simulation International-presentation

7th East Asian Consortium on Biomedical Engineering　2013/11/18
Stagnant Blood Flow in Intracranial Aneurysms: A Possible Association with Atherosclerosis

Shin-ichiro Sugiyama, Toshio Nakayama, Kenichi Funamoto, Daichi Suzuki, Kuniyasu Niizuma, Makoto Ohta, Teiji Tominaga

Tenth International Conference on Flow Dynamics Proceedings　2013/11
Ultrasonic-Measurement-Integrated Simulation of Complex Blood Flow International-presentation

The International Workshop on Flow Dynamics Related to Energy, Aerospace and Material Science　2013/09/11
マイクロ流体デバイスを用いた細胞の低酸素応答の観察

日本機械学会2013年度年次大会　2013/09/10
Fundamental Study on Micro Calcification Detection Using Twinkling Sign (TS): The Effect of Stiffness of Surrounding Tissue on the Appearance of TS International-presentation

The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’13)　2013/07/04
Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation International-presentation

35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’13)　2013/07/04
Frictional Characteristics of Erythrocytes on Endothelia-Cultured or Material-Coated Glass Plates Subject to Inclined Centrifugal Forces International-presentation

8th International Conference on Multiphase Flow (ICMF 2013)　2013/05/29
超音波計測融合シミュレーションによる生体内の血液粘度の推定

日本超音波医学会第86回学術集会　2013/05/24
軟組織内微細石灰化Twinkling Signに関する実験的研究：粒子径，粒子種類が与える影響

日本超音波医学会第86回学術集会　2013/05/24
超音波Mモードイメージングと光電容積脈波センシングによる脈波同定の比較

日本超音波医学会第86回学術集会　2013/05/24
超音波計測融合シミュレーションによる生体内の血液粘度の推定

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 地挽隆夫, 橋本浩, 見山広二, 劉磊

超音波医学　2013/04
超音波Mモードイメージングと光電容積脈波センシングによる脈波同定の比較

曾根周作, 早瀬敏幸, 船本健一

超音波医学　2013/04
脳動脈瘤内の3次元血流解析とMRI計測の比較

日本機械学会第25回バイオエンジニアリング講演会　2013/01/11
マイクロ流体デバイスを用いた低酸素下におけるがん細胞の挙動の観察

日本機械学会第25回バイオエンジニアリング講演会　2013/01/11
頸動脈内の3次元血流場に対する2次元超音波計測融合シミュレーションの解析精度の検証

日本機械学会第25回バイオエンジニアリング講演会　2013/01/10
超音波計測融合シミュレーションによる血液粘度の推定

日本機械学会第25回バイオエンジニアリング講演会　2013/01/10
血管内圧による狭窄部の形状変化と血流分布の関連性

日本機械学会第25回バイオエンジニアリング講演会　2013/01/10
小動物用超音波計測連成解析システムによるマウスの頸動脈の血流解析

日本機械学会第25回バイオエンジニアリング講演会　2013/01/10
酸素濃度制御下の細胞実験のためのマイクロ流体デバイスの設計

COMSOL Conference Tokyo 2012　2012/11/22
低酸素下細胞実験のためのマイクロ流体デバイスの開発

日本機械学会第４回マイクロ・ナノ工学シンポジウム　2012/10/23
脳動脈瘤破裂点の流体力学的特徴: コンピュータ流体解析による検討

日本脳神経外科学会第71回学術総会　2012/10/19
小動物用超音波計測連成解析システムにおける血管形状抽出の高精度化

坂西山河, 早瀬敏幸, 船本健一, 曾根周作

日本機械学会第23回バイオフロンティア講演会　2012/10/06
2次元超音波計測融合シミュレーションによる頸動脈分岐部の血流解析

日本機械学会第23回バイオフロンティア講演会　2012/10/05
Neumerical and Experimental Study of Flow in Stenosis models with Several Mechanical Properties International-presentation

The 9th International Conference on Flow Dynamics (ICFD2012)　2012/09/21
Rheological Analysis of the Mechanism of Fetal Brain Hemorrhage International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Ultrasound Radiation Force Driven B-Flow Twinkling Sign for Microcalcification Detection International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Moving on to the Small World: Microfluidic Cell Culture International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Magnetic Resonance Fluid Dynamics for Intracranial Aneurysms International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Observation of Hypoxia Cellular Response by Using Microfluidic Devices International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Computational Simulation to Create Low Oxygen Tension in a Microfluidic Device for Cell Culture International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope - Effect of Asymmetric Cell Shape on the Motion International-presentation

Takashi Oshibe, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

The 9th International Conference on Flow Dynamics (ICFD2012)　2012/09/20
Oxygen Tension Control in a Microfluidic Device for Cell Culture International-presentation

The 9th International Conference on Flow Dynamics (ICFD2012)　2012/09/19
Intra-left Atrial Flow International-presentation

The 9th International Conference on Flow Dynamics (ICFD2012)　2012/09/19
A Novel Approach to Understanding Perinatal Hypoxic-Ischemia International-presentation

The 11th World Congress in Fetal Medicine　2012/06/24
視覚協創学(9)：視覚協創による血流動態のリアライゼーション

早瀬敏幸, 船本健一, 曾根周作, 坂西山河

第17回計算工学講演会　2012/05/30
軟組織内微細石灰化のB-Flow“Twinkling Sign”発生メカニズムに関するin vitro研究

日本超音波医学会第85回学術集会　2012/05/26
2次元超音波計測融合シミュレーションによる頸動脈分岐部の非定常血流量推定

日本超音波医学会第85回学術集会　2012/05/25
Oxygen sensors for microfluidic 3D cell cultures International-presentation

EUROPT(R)ODE XI Conference on Optical Chemical Sensors and Biosensors　2012/04/02
2次元超音波計測融合シミュレーションによる頸動脈分岐部の非定常血流量推定

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

超音波医学　2012/04
頸動脈分岐部内血流の2次元超音波計測融合シミュレーション

日本機械学会第24回バイオエンジニアリング講演会　2012/01/08
傾斜遠心顕微鏡下での赤血球の浮上機構に関する数値解析第2報：剛体赤血球モデルによる摩擦特性の再現性の検討

日本機械学会第24回バイオエンジニアリング講演会　2012/01/08
Flow Analysis of Rupture Point in Cerebral Aneurysms: Computational Fluid Dynamics Study International-presentation

The 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2011/12/13
Numerical Analysis of the Effect of Angle of Attack on a Red Blood Cell Moving in an Inclined Centrifuge Microscope International-presentation

The 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2011/12/13
Two-Dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow in Bifurcation of Carotid Artery International-presentation

The 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2011/12/13
Comparison between Ultrasonic-Measurement-Integrated Simulation and Ordinary Simulation with Measured Upstream Velocity Condition International-presentation

The 8th International Conference on Flow Dynamics　2011/11/10
Computational Simulation of Blood Flow in Intracranial Aneurysms under Patient-Specific Pulsatile Inlet Condition International-presentation

The 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　2011/11/10
Detection of Microcalcification in Soft Tissue Employing B-Flow ”Twinkling” Sign International-presentation

The 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　2011/11/10
Left Atrial Vortex International-presentation

The 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　2011/11/10
Rheological Analysis of the Mechanism of Fetal Brain Hemorrhage International-presentation

The 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　2011/11/10
微細石灰化を含んだ乳房組織を模擬したPVA phantomの実験的研究

第49回人工臓器学会　2011/11
傾斜遠心顕微鏡下での赤血球浮上機構に関する数値解析

日本機械学会第22回バイオフロンティア講演会　2011/10/07
Hemodynamic Changes in the Left Atrium due to Atrial Fibrillation International-presentation

The ASME 2011 Summer Bioengineering Conference　2011/06/24
“Twinkling Sign”を応用した軟組織内微細石灰化検出に関する基礎的研究

日本超音波医学会第84回学術集会　2011/05/28
超音波計測融合シミュレーションと計測による上流速度を与えたシミュレーションの比較

日本超音波医学会第84回学術集会　2011/05/28
超音波計測融合シミュレーションと計測による上流速度を与えたシミュレーションの比較

曾根周作, 加藤宇海, 船本健一, 早瀬敏幸, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

超音波医学　2011/04
Integration of Ultrasound Color Doppler Imaging and Numerical Simulation International-presentation

The 2nd International Conference on Computational and Mathematical Biomedical Engineering (CMBE11)　2011/04/01
頚動脈モデルを用いた超音波計測融合血流シミュレーションの検証実験

第23回バイオエンジニアリング講演会　2011/01/08
Blood Flow Analysis in the Left Atrium with/without Atrial Fibrillation International-presentation

The 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2010/12/16
Experimental Validation of Ultrasonic-Measurement-Integrated Blood Flow Simulation Using Carotid Artery Models International-presentation

The 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2010/12/15
MR-Measurement-Integrated Simulation for Reproduction of Blood Flow in Cerebral Aneurysm International-presentation

Swiss/Japan International Seminar on Medical Engineering Based on Vessel Biology　2010/11/15
小動物用超音波計測融合シミュレーションシステムの開発（検証実験）

第21回バイオフロンティア講演会　2010/11/13
超音波計測融合シミュレーションによる頚動脈内の壁せん断応力の評価

第21回バイオフロンティア講演会　2010/11/13
心房細動に関する左心房内血流解析

第21回バイオフロンティア講演会　2010/11/12
Computer Simulation Predicts the Convective Drug Distribution in the Primate Brainstem International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Consideration for Simulations of Infusion in Realistic Animal Brain Geometries International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Detection of Microcalcification in Soft Tissue International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Evaluation of Wall Shear Stress on Carotid Artery with Ultrasonic-Measurement-Integrated Simulation International-presentation

The seventh International Conference on Flow Dynamics　2010/11/02
Fluid Analysis of the Mechanism of Fetal Brain Hemorrhage International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Left Atrial Appendage International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
医療計測との融合による血流解析

日本機械学会第88期流体工学部門講演会　2010/10/31
血流の超音波計測融合シミュレーションにおけるゼロ表示されたドプラ速度のフィードバックの影響

日本流体力学会年会2010　2010/09/10
Computational Simulation on Convection-Enhanced Drug Delivery into the Primate Brain International-presentation

The 6th World Congress of Biomechanics　2010/08/04
Effect of Measurement Error on Ultrasonic-Measurement-Integrated Simulation of Blood Flow in an Aortic Aneurysm International-presentation

The 13th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　2010/08/04
Visualization of Microcirculation Based on Brightness Variation in Contrast-Enhanced Ultrasound International-presentation

ASME 2010 Summer Bioengineering Conference　2010/06/17
超音波計測融合シミュレーションによる臨床応用に関する基礎的研究

日本超音波医学会第83回学術集会　2010/05/30
超音波計測融合シミュレーションによる分岐血管の流量推定

日本超音波医学会第83回学術集会　2010/05/29
傾斜遠心力下における赤血球挙動の流体構造連成解析

第15回計算工学講演会　2010/05/26
大動脈瘤内における非定常血流に関する情報探査

第15回計算工学講演会　2010/05/26
2次元下行大動脈瘤近傍における血流の計測融合シミュレーションに関する固有値解析

日本機械学会東北支部第45期総会・講演会　2010/03/12
Clinical Application of Ultrasonic-Measurement-Integrated Simulation for Diagnosis of Carotid Artery International-presentation

SMART-Tohoku GCOE joint Workshop on Micro & Nano Bioengineering: MIT, NUS, NTU and Tohoku　2010/01/12
集中定数モデルによる循環器系病態の動特性解析第2報：心室中隔欠損症の考察

第22回バイオエンジニアリング講演会　2010/01/10
超音波Bモード画像の輝度値の変動に基づく微小循環の可視化

第22回バイオエンジニアリング講演会　2010/01/10
PVA頚動脈モデルを用いた3次元超音波計測融合血流シミュレーション

第22回バイオエンジニアリング講演会　2010/01/09
Analysis of Clinical Data with Ultrasonic-Measurement-Integrated Simulation International-presentation

The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
Dynamic Characteristics Analysis of Diseased Circulatory System with Lumped Parameter Model 1st Report : Heart Valve Disease International-presentation

The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
Eigenvalue Analysis for Error Dynamics of Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aneurismal Aorta International-presentation

The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
Three-Dimensional Ultrasonic-Measurement-Integrated Blood flow Simulation using PVA Carotid Artery Model International-presentation

The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
血流の超音波計測融合シミュレーションに関する研究第9報：計測ノイズの影響

第20回バイオフロンティア講演会　2009/11/08
集中定数モデルによる循環器系病態の動特性解析第1報：心臓弁膜症の考察

第20回バイオフロンティア講演会　2009/11/08
超音波計測融合シミュレーションによる臨床データの解析

第20回バイオフロンティア講演会　2009/11/07
Atrial Vortex International-presentation

The 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
Blood Flow Analysis by Measurement-Integrated Simulation International-presentation

The 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
Convection-enhanced Delivery of ACNU under MRI Monitoring against Recurrent Gliomas-Development of Computational Simulation of Drug Distribution International-presentation

The 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
Fundamental Study of Convection-Enhanced Delivery Simulation in Rat Brain International-presentation

The 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
MRI計測に基づく数値シミュレーションを用いた左心房内壁せん断応力の検討

第12回日本栓子検出と治療学会　2009/10/10
生体モデリングにおける音響特性の制御と超音波計測

計測自動制御学会東北支部45周年記念学術講演会　2009/09/08
Reproduction of Blood Flow Field by Numerical Simulation Integrated with Ultrasonic Measurement with Noise International-presentation

ASME 2009 Summer Bioengineering Conference　2009/06/18
超音波計測融合シミュレーションによる血行力学情報のリアルタイム可視化に関する研究

日本超音波医学会第82回学術集会　2009/05/24
Effect of Aliasing on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow International-presentation

The 10th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　2009/04/17
Fluid-Structure Coupled Ultrasonic-Measurement-Integrated Simulation of Fluid in Elastic Tube with Contraction International-presentation

9th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　2009/03
血流の超音波計測融合シミュレーションに関する研究第8報：計測誤差の影響

第21回バイオエンジニアリング講演会　2009/01
生体に近い音響特性を有するPVAゲルの開発

第21回バイオエンジニアリング講演会　2009/01
Numerical Evaluation of MR-Measurement-Integrated Simulation of Unsteady Hemodynamics in a Cerebral Aneurysm International-presentation

Kenichi Funamoto, Yoshitsugu Suzuki, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

The 8th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　2008/12
MR-Measurement-Integrated Simulation of Blood Flow in Cerebral Artery International-presentation

Tsinghua University and IFS, Tohoku University Joint Workshop　2008/10
MR計測融合シミュレーションによる脳動脈瘤内の非定常流再現の数値実験

船本健一, 鈴木禎嗣, 早瀬敏幸, 小杉隆司, 礒田治夫

第19回バイオフロンティア講演会　2008/09
Numerical Experiment of MR-Measurement-Integrated Simulation of Steady Blood Flow in a Cerebral Aneurysm International-presentation

Kenichi Funamoto, Yoshitsugu Suzuki, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

ASME 2008 Summer Bioengineering Conference　2008/06
MR計測融合シミュレーションによる脳動脈瘤内の定常流再現の数値実験

船本健一, 鈴木禎嗣, 早瀬敏幸, 小杉隆司, 礒田治夫

第13回計算工学講演会　2008/05
超音波計測融合シミュレーションによる血流場の可視化

船本健一, 早瀬敏幸, 劉磊, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

日本超音波医学会第81回学術集会　2008/05
Numerical Evaluation of Ultrasonic-Measurement-Integrated Simulation of Blood Flow International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

The 5th International Bio-Fluid Symposium and Workshop　2008/03
超音波計測融合シミュレーションにおける直円管内層流の解析（非軸対称フィードバック則による3次元解析）

船本健一, 劉磊, 早瀬敏幸

第20回バイオエンジニアリング講演会　2008/01
Effect of Time Resolution of Measurement on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow in an Aneurysmal Aorta International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

The 3rd Tohoku-NUS Joint Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region　2007/12
ナノバブルと高周波超音波による腫瘍内血管の三次元画像の構築(Construction of three-dimentional image of intratumoral vessel using high-frequency contrast-enhanced micro-ultrasound)

冨田典子, 堀江佐知子, 渡邊夕紀子, 船本健一, 早瀬敏幸, 大木宏介, 森川秀広, 小野栄夫, 森士朗, 小玉哲也

日本癌学会総会記事　2007/08
Accuracy of Ultrasonic-Measurement-Integrated Simulation for Three-Dimensional Blood Flow in Aneurysmal Aorta International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

The 5th Joint ASME/JSME Fluids Engineering Conference　2007/07
血流の超音波計測融合シミュレーションに関する研究第7報：計測の時間分解能の影響

船本健一, 早瀬敏幸, 西條芳文, 山家智之

第19回バイオエンジニアリング講演会　2007/01
3次元非定常血流の超音波計測融合シミュレーションに関する数値実験

船本健一, 早瀬敏幸, 西條芳文, 山家智之

日本機械学会第84期流体工学部門講演会　2006/10
血流の超音波計測融合シミュレーションに関する研究第6報：3次元非定常血流解析

船本健一, 早瀬敏幸, 西條芳文, 山家智之

日本機械学会2006年度年次大会　2006/09
Improvement of Accuracy of Blood Flow Simulation by Integrating Measurement Using Ultrasonic Doppler Method International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

The 5th World Congress of Biomechanics　2006/07
Fundamental Study of Transient Characteristics of Ultrasonic-Measurement-Integrated Simulation toward Reproduction of Unsteady Blood Flows International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

ASME 2006 Summer Bioengineering Conference　2006/06
超音波ドプラ計測を融合した3次元血流解析に関する基礎的研究

船本健一, 早瀬敏幸, 西條芳文, 山家智之

計測自動制御学会東北支部第228回研究集会　2006/05
637 Blood Flow Simulation Integrated with Ultrasonic Measurement : 6^<th> Report : Three-Dimensional Unsteady Blood Flow Simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2006

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Development and progress of circulatory diseases are closely related to the hemodynamics in the blood vessel. However, detailed and accurate information of blood flow field has yet to be obtained due to the limitations both in measurement and numerical simulation. Hence, we have proposed the Ultrasonic-Measurement-Integrated (UMI) simulation. In this method, feedback signals derived from the difference between measured and computed Doppler velocities are fed back to the numerical simulation. The transient and steady characteristics of the UMI simulation have been revealed. In this paper, we performed the numerical experiment aiming at the reproduction of the three-dimensional unsteady flow field. As the result, the application of the feedback in the UMI simulation made the computational results converge and trace to the model of real blood flow.
S-14 超音波による心臓・血管の中の流れの医工学的解析(特別企画II(要望演題5) 逆流性疾患・閉塞性疾患・拡張性疾患に対する治療戦略-管と流れと-,第43回日本小児外科学会総会)

西條芳文, 白石泰之, 関根一光, 山家智之, 田中元直, 田林晄一, 早瀬敏幸, 船本健一, 大槻茂雄, 菅原重生

日本小児外科学会雑誌　2006
3次元超音波計測融合シミュレーションにおけるフィードバック点の異方的配置の影響

船本健一, 早瀬敏幸, 西條芳文, 山家智之

第18回バイオエンジニアリング講演会　2006/01
Effect of Ultrasound Probe Placement in Ultrasonic-Measurement-Integrated Simulation of Blood Flows International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

The 12th International Conference on Biomedical Engineering (ICBME 2005)　2005/12
血流の超音波計測融合シミュレーションに関する研究第5報：3次元非定常血流場の再現

船本健一, 早瀬敏幸, 西條芳文, 山家智之

第16回バイオフロンティア講演会　2005/11
Effect of Feedback Domain in Ultrasonic-Measurement-Integrated Simulation on Reproduction of Blood Flow Field in an Aneurysmal Aorta International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

The 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)　2005/11
3次元超音波計測融合血流シミュレーションのフィードバック方式に関する検討

船本健一, 早瀬敏幸, 西條芳文, 山家智之

日本機械学会第83期流体工学部門講演会　2005/10
3次元超音波計測融合血流シミュレーションにおけるフィードバック点配置の影響

船本健一, 早瀬敏幸, 西條芳文, 山家智之

日本流体力学会年会2005　2005/09
血流の超音波計測融合シミュレーションに関する研究第4報：血行力学解析の高精度化

船本健一, 早瀬敏幸, 西條芳文, 山家智之

日本機械学会2005年度年次大会　2005/09
Ultrasonic-Measurement-Integrated Simulation for Reproduction of Three-Dimensional Blood Flow Field in the Aorta with Aneurysm International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

ASME 2005 Summer Bioengineering Conference　2005/06
超音波計測融合血流シミュレーションの開発

船本健一, 早瀬敏幸, 西條芳文, 山家智之

第1回21世紀COE8大学拠点合同シンポジウム　2005/03
Effect of Density of Monitoring Points for Feedback in Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta with Aneurysm International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

The 3rd IASTED International Conference on Biomedical Engineering (BioMED2005)　2005/02
1108 Blood Flow Simulation Integrated with Ultrasonic Measurement : 4^<th> Report: Improvement of Accuracy of Computational Hemodynamics

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2005

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Hemodynamics plays an important role in the development, progress and rupture of aneurysms, and therefore, is essential for advanced diagnosis. However, existing methodologies have yet to provide detailed and accurate information of blood flow field due to their individual limitations. As a solution to the problem, we have proposed Ultrasonic-Measurement-Integrated (UMI) simulation. In this method, feedback signals derived from the difference between measured Doppler velocity and the calculated one by numerical simulation are fed back to the numerical simulation. In this paper, we validate the efficacy of three-dimensional UMI simulation by the numerical analysis with various irradiation methods of ultrasonic beam. As the result, UMI simulation improves computational accuracy and enables us to obtain more accurate information of blood flow field including wall shear stress.
410 Study of Three-dimensional Feedback Law for Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the JSME Bioengineering Conference and Seminar　2005
Measurement-Integrated Simulation for Numerical Realization of Complex Bio-Fluid Systems

Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

Proceedings of the 2nd International Symposium on Intelligent Artifacts and Bio-Systems, 2nd INABIO　2005
Transdisciplinary Methodology Integrating Measurement and Simulation in Application of Complex Biomedical Flows

Toshiyuki Hayase, Kenichi Funamoto, Takayuki Yamagata, Lei Liu, Atsushi Shirai, Makoto Ohta, Kosuke Inoue, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 5th International Symposium on Advanced Fluid information (AFI-2005)　2005
超音波計測融合シミュレーションの3次元フィードバック則に関する検討

船本健一, 早瀬敏幸, 西條芳文, 山家智之

第17回バイオエンジニアリング講演会　2005/01
血流の超音波計測融合シミュレーションにおけるエイリアジングの除去

船本健一, 早瀬敏幸, 西條芳文, 山家智之

計測自動制御学会東北支部40周年記念学術講演会　2004/12
血流の超音波計測融合シミュレーションに関する研究第3報：3次元血流場の再現

船本健一, 早瀬敏幸, 西條芳文, 山家智之

第15回バイオフロンティア講演会　2004/11
Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta with an Aneurysm International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

The 4th International Symposium on Advanced Fluid Information and the 1st International Symposium on Transdisciplinary Fluid Integration (AFI/TFI-2004)　2004/11
超音波計測融合シミュレーションによる大動脈血流解析

船本健一, 早瀬敏幸, 西條芳文, 山家智之

日本機械学会2004年度年次大会　2004/09
超音波計測融合血流シミュレーションのフィードバック則に関する検討

船本健一, 早瀬敏幸, 白井敦, 西條芳文, 山家智之

日本流体力学会年会2004　2004/08
Application of Ultrasonic-Measurement-Integrated Simulation to Blood Flow International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Yoshifumi Saijo, Tomoyuki Yambe

The 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)　2004/06
Analysis of Blood Flow in Aorta with Ultrasonic-Measurement-Integrated Simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2004

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In order to reproduce the blood velocity and pressure fields of the blood flow for an accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms, we are developing a new analysis methodology, namely Ultrasonic-Measurement-Integrated (UMI) simulation, by integrating color Doppler ultrasonography and numerical simulation. In the UMI simulation, feedback signals are added to the governing equations to compensate for the difference between computation and measurement. In this paper, we perform UMI simulation for the blood flow in descending aorta with an aneurysm. It is revealed that the UMI simulation reproduces the complicated blood flow structure and detects the incorrect measurement data.
Basic Study of Ultrasonic-Measurement-Integrated Simulation System

YAMAGATA Takayuki, Funamoto Kenichi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2004

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Detailed information of the velocity and pressure field of the blood flow is essential to establish an advanced diagnosis and treatment of serious circulatory diseases. Commonly used medical measurement equipments cannot measure such information, while even state-of-the-art numerical simulation cannot reproduce real blood flow accurately. In order to overcome this problem, the authors have proposed a new technique, Ultrasonic-Measurement-Integrated (UMI) simulation, that integrates ultrasonic measurement equipment and numerical, simulation, and revealed its usefulness by numerical simulation. The present report describes the development of fundamental procedure of the interface between ultrasonic equipment and simulation, and acceleration of computational speed for real time operation. By considering the tolerance of the solution, computational speed has been accelerated by a factor of 90 achieving only ten times longer computational time than real phenomena.
血流の超音波計測融合シミュレーションに関する研究第2報：大動脈瘤内の血流の再現

船本健一, 早瀬敏幸, 白井敦, 山家智之, 西條芳文

第16回バイオエンジニアリング講演会　2004/01
Reproduction of Real Blood Flow in Aorta with Ultrasonic-Measurement-Integrated Simulation

Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

東北大学流体科学研究所第15回研究発表会　2003/12
Reproduction of Real Blood Flow in Aorta with Ultrasonic-Measurement-Integrated Simulation International-presentation

Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

The 3rd International Symposium on Advanced Fluid Information (AFI-2003)　2003/11
血流の超音波計測融合シミュレーションに関する研究第1報：上流速度境界条件に起因する誤差の改善

船本健一, 早瀬敏幸, 白井敦, 山家智之, 西條芳文

第14回バイオフロンティア講演会　2003/09
Evidence-based Simulation of Blood Flow with Feedback of Ultrasonic Measurement

Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

The 1st International Symposium on Future Medical Engineering based on Bio-nanotechnology　2003/01
Numerical Realization of Flow by Integrating Computation and Measurement in Medical Applications Invited

Toshiyuki Hayase, Kenichi Funamoto, Keisuke Nisugi, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

Proceedings of Mini-Symposium on Advanced Fluid Information: Fusion of EFD and CFD　2002/12
流れの数値解析を融合した超音波診断装置の基礎的研究

船本健一, 早瀬敏幸, 白井敦

第45回自動制御連合講演会　2002/11
Numerical Simulation of Red Blood Cell under Inclined Centrifugal Force

FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi

The proceedings of the JSME annual meeting　2002/09/20

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Two dimensional flow analysis was performed to simulate the former experiment using the inclined centrifuge microscope for the frictional characteristics of red blood cells moving on a glass plate in a medium. Lift, drag and momentum acting on a red blood cell were obtained in various conditions. Considering a balance among various forces acting on a red blood cell, the frictional characteristics of a red blood cell were modeled as the sum of Coulomb friction and drag. The result indicates the possibility that a red blood cell deforms to expand on the front side, and the plasma layer of the thickness of 0.16 μm exists on a glass plate.

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Industrial Property Rights 4

超音波診断装置および血流量推定プログラム

早瀬敏幸, 船本健一, 門脇弘子

特許第5958806号

Property Type: Patent
超音波診断装置、血流可視化装置および制御プログラム

早瀬敏幸, 船本健一, 見山広二

特許第5522719

Property Type: Patent
脳性麻痺発症仔の作成方法

木村芳孝, 伊藤拓哉, 船本健一, 早瀬敏幸

Property Type: Patent
血流可視化診断装置

早瀬敏幸, 船本健一, 白井敦, 山家智之, 西條芳文

特許第4269623

Property Type: Patent

Research Projects 26

マイクロ流体デバイスを用いた細胞群の低酸素応答の解明 Competitive

System: The Other Research Programs

2011/02 - Present
超音波を用いた医療イメージングに関する研究 Competitive

System: The Other Research Programs

2007/04 - Present
Measurement-Integrated Simulation of Blood Flow Competitive

System: The Other Research Programs

2007/04 - Present
血管壁MRイメージングと数値流体解析を駆使した脳動脈瘤増大予測モデルの開発

面高俊介, 中川敦寛, 新妻邦泰, 杉山慎一郎, 園部真也, 遠藤英徳, 船本健一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04/01 - 2027/03/31
Development of vascular permeability control method by integration of blood-brain barrier-on-a-chip and measurement-integrated simulation

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2023/04/01 - 2027/03/31
脳血管-神経ユニット・胎盤エクソソーム輸送系を軸とした胎盤-脳連関機構解明と応用

立川正憲, 船本健一, 福田達也, 吉田あつ子

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 徳島大学

2022/04/01 - 2026/03/31
金魚免疫系×ヒトモデル化血液脳関門チップで変革する中枢送達型抗体開発

立川正憲, 田丸浩, 船本健一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的研究(萌芽)

Institution: 徳島大学

2022/06/30 - 2025/03/31

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核酸やタンパク質を新たなモダリティーとする高分子薬を中枢疾患治療薬として開発する場合、ヒト血液脳関門(Blood-Brain Barrier, BBB)の突破戦略の構築は重要な課題である。近年、BBB受容体に結合する抗体と薬物との複合体を創製し、受容体介在型トランスサイトーシス機構(Receptor-Mediated Transcytosis, RMT)を利用してBBB突破を図る技術が注目されている。一方で、BBBにおける標的受容体は限定的であり、新たな受容体介在型トランスサイトーシスの分子実体の同定が必要である。本研究では、ヒト脳血管内皮細胞の細胞膜画分に対する抗体を創製し、BBBにおいてRMTの第一ステップとなる受容体介在型エンドサイトーシス機能を有する受容体を同定することを目的とした。ヒトBBBモデルとして脳微小血管内皮細胞(hCMEC/D3細胞)の細胞膜画分を抗原としてマウスに免疫し、ポリクローナル抗体を含む血清を取得した。免疫沈降とプロテオミクスを組み合わせた手法を用い、hCMEC/D3細胞の細胞膜タンパク質に対する抗体と結合する受容体タンパク質を同定した。同定した受容体の介在型エンドサイトーシス機能は、標的タンパク質に対するモノクローナル抗体の内皮細胞への内在化を検出することで評価した。その結果、抗体に結合するhCMEC/D3細胞の膜タンパク質として、既知のトランスフェリン受容体を含めて新規分子を同定した。同定された分子に対するモノクローナル抗体は、hCMEC/D3細胞へ内在化活性を示し、細胞内において粒子状のシグナルが検出された。同分子をノックダウンしたhCMEC/D3細胞では、抗体の内在化活性が有意に低下した。以上から、BBBにおいて介在型エンドサイトーシス機能を有する受容体の同定に至った。
血流解剖に基づく未破裂脳動脈瘤分類および新規画像診断システムの提案

杉山慎一郎, 新妻邦泰, 安西眸, 船本健一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2025/03/31
Elucidation of pathological molecular mechanisms involved in pregnancy hypertension using human placental organoid chips

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tokyo University of Agriculture and Technology

2021/04/01 - 2024/03/31
血管壁イメージングMRIと瘤内血流のAI解析による脳動脈瘤破裂点の推定

面高俊介, 中川敦寛, 新妻邦泰, 杉山慎一郎, 園部真也, 遠藤英徳, 船本健一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

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本研究では近年明らかになったMRIにおける脳動脈瘤壁の造影効果を破裂点の予測に応用し、さらにCFD (数値流体解析: computational fluid dynamics) 解析及びAI (人工知能: artificial intelligence) 解析を組み合わせることで、従来は主に形態学的特徴から予測していた破裂点をより高い精度で予測する手法を確立する。初年度である当該当年度は後ろ向き研究として主に患者データの収集を行った。画像データ（MRI及び脳血管撮影の3次元データ）を院内放射線サーバーからPCへ移す作業を行った。予定していた約400例分のうち2/3程終了した。移行した画像データを用いて画像解析ソフトを用いた瘤壁造影効果の評価、流体解析ソフトを用いたCFD解析を同時に進めているところである。現在のところ中間結果の段階であるが破裂点の予測にはMRIにおける瘤壁造影効果は非常に有用であるとの結果が得られつつある。すなわちくも膜下血種の患者さんで術前に造影MRIを行うことで事前に破裂点を予測しうるとの結果が得られており今後解析が進むにつれて根拠が増すものと予想される。現在移行している画像データはAI解析にも活用でき、将来的にはAI解析も進めることを視野に入れている。関連する検討として同データベースを用いて切迫破裂例における瘤壁臓絵効果に関する検討を行い論文化（Omodaka S et al. J Neurosurg. 2022）、学会発表 (脳神経外科総会2021, Stroke 2022)を行い、瘤壁造影効果の臨床的意義を示すことができており本研究成果の一部であるとともに本研究を後押しする成果が得られている。
実効粘度の非接触測定に向けた慣性移動を伴う懸濁液流れの数値的・実験的研究

川口美沙, 福井智宏, 船本健一

Offer Organization: 東北大学流体科学研究所

System: 令和5年度リーダーシップ共同研究

2023/04 - 2024/03
ヒトウイルス受容体を介した血液脳関門突破機構に基づくエクソソームの脳細胞標的化

立川正憲, 船本健一, 福田達也

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(B)

Category: 基盤研究(B)

Institution: 徳島大学

2019/04/01 - 2023/03/31

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高分子中枢薬の脳への薬物送達を実現するためには、脳毛細血管内皮細胞を実体とする血液脳関門(Blood-Brain Barrier, BBB)の透過技術に加え、神経細胞やグリア細胞への輸送標的化の基盤技術開発が重要である。そこで本研究は、ヒトBBBにおけるエクソソーム輸送の仕組みを解明することを目的とした。ヒト神経芽細胞腫SH-SY5Y細胞の培養上清から、超遠心分離法を用いて細胞外膜小胞の単離を行った結果、細胞外膜小胞は、平均粒子径約120 nmであり、エクソソームの物理化学的特性を有していることが示された。回収したエクソソームをPKH67で蛍光標識し、ヒトBBB in vitroモデル細胞（hCMEC/D3細胞）への取り込み活性及び温度依存性を解析した。エクソソームの細胞内取り込みは、37℃と比較し4℃において有意に低下することが示され、エクソソームのBBB輸送には、脳毛細血管内皮細胞内へのエネルギー依存的な取り込み機構が関与することが示唆された。BBB輸送の分子機構を解明するため、エクソソーム上のリガンド-BBB受容体タンパク質の相互作用を明らかにすることは重要である。そこで、網羅的定量プロテオミクスを用いて、エクソソーム上に発現するタンパクを網羅的に同定し、ヒト脳血管内皮細胞上の膜タンパク質との相互作用についてパスウエイ解析や文献情報をもとに、絞り込みを行った。以上の結果から、エクソソームをキャリアーとして用いた脳への高分子薬送達の学術的基盤構築につながるデータを蓄積することができた。
Investigation of the mechanism and prevention for ischemia-reperfusion injury by using blood-brain barrier-on-a-chip

Funamoto Kenichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2019/04/01 - 2022/03/31

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Microvascular network was created by culturing vascular endothelial cells and fibroblasts mixed in a fibrin gel placed in a chip with controllability of oxygen concentration and mechanical and chemical stimuli. Gas mixtures were supplied to the gas channels in the chip to generate a steady state of normoxic or hypoxic conditions at oxygen concentration of 21% or 0.3%, respectively, or repeatedly change the two oxygen conditions. Immediately after the reoxygenation from the hypoxic state, reactive oxygen species were produced, and the permeability of microvascular network was significantly increased. The same tendency of the permeability increase by changes of oxygen concentration was observed in the microvascular network that mimicked human blood-brain barrier with vascular endothelial cells, pericytes, and astrocytes.
Search for prevention method of fetal dysfunction by placenta-on-a-chip

Funamoto Kenichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2018/06/29 - 2022/03/31

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Placenta-on-a-chip was used to reproduce a characteristic three-dimensional layered structure of human placenta, in which the syncytiotrophoblast and cytotrophoblast, as well as the fetal vasculature, are located across the stroma. Fibrin gel, fibrin gel mixed with vascular endothelial cells and fibroblast cells, and cell suspensions of placental cells were injected into the three parallel gel channels and their adjacent media channels at different timings to reveal the process of human placenta formation. In addition, quantitative evaluation of material exchange between mother and fetus was achieved by measuring permeability of the trophoblast and microvascular network under controlled culture conditions. Furthermore, we developed an experimental setup to observe the dynamics of a single layer of vascular endothelial cells under hypoxia and flow exposure, and showed that their stimuli promote morphological changes.
Inflammatory responses to crystals and nanoparticles

Nakayama Masafumi, Kinoshita Kengo

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2016/04/01 - 2019/03/31

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The inhalation of silica dust is associated with fibrosis and lung cancer, which are triggered by macrophage inflammatory responses; however, how macrophages recognize silica remains largely unknown. Here we identify by functional expression cloning the class B scavenger receptor SR-B1 as a silica receptor. Genetic deletion of SR-B1 and masking of SR-B1 by monoclonal antibodies showed that SR-B1-mediated recognition of silica is associated with caspase-1-mediated inflammatory responses in mouse macrophages and human peripheral blood monocytes. Furthermore, SR-B1 was involved in silica-induced pulmonary inflammation in mice. These results indicate that SR-B1 is a silica receptor associated with canonical inflammasome activation.
Control of Cellular Responses with 3-in-1 Chip Mimicking In Vivo Microenvironment

Funamoto Kenichi, KAMM Roger, YOSHINO Daisuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2016/04/01 - 2019/03/31

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3-in-1 chip mimicking in vivo microenvironment was developed to simultaneously control oxygen tension and mechanical and chemical stimuli to cells. The microfluidic chip enabled to generate a uniform oxygen state down to 0.3% or a linear oxygen gradient within 15 minutes by supplying gas mixtures into the gas channels in the chip. Behavior of the human breast cancer cells suspended in type I collagen gel were then observed while controlling oxygen tension using the developed chip. As the results, it was revealed that the hypoxic environment promoted the proliferation and migration of the cancer cells. Moreover, the hypoxic response of breast cancer cells was changed by cell-cell interaction when co-cultured with vascular endothelial cells.
Investigation of mechanical properties of tumor microenvironment with spatial and temporal heterogeneity of oxygen tension for control of tumor cell behavior(Fostering Joint International Research)

Funamoto Kenichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Institution: Tohoku University

2017 - 2019

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Effects of spatiotemporal heterogeneity of oxygen concentration on mechanical properties of cancer cells and the surrounding extracellular matrix were investigated. A 3-in-1 chip which reproduces in vivo microenvironment was developed and employed to simultaneously control oxygen tension and mechanical and chemical stimuli to cells. Proliferation and migration speed of human breast cancer cell (MDA-MB-231 cell line) were increased under hypoxia than those under normoxia. However, these tendencies became unclear when the cancer cells were co-cultured with the vascular endothelial cells. Contraction and degradation of collagen gel was promoted under the co-culture condition, but its speed was slowed down by hypoxic exposure. Thus, it was found that changes of the cancer cell behaviors and the surrounding extracellular matrix as well as their interactions were oxygen-dependent.
New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery

Sugiyama Shinichiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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Spinal cord injury has dismal prognosis even in this modern era. Convection-enhanced delivery (CED) is a method for distributing small and large molecules locally in the interstitial space of the spinal cord. Delivering these molecules to the spinal cord is otherwise difficult due to the blood spinal cord barrier. This study revealed that regional infusion of drugs into the spinal cord via CED is a promising strategy for treating spinal cord injury. In addition, we investigated the safety and efficacy of stem cell transplantation (multilineage-differentiating stress enduring cell (Muse cell) transplantation) in spinal cord injury.
Challenge for development of placenta-on-a-chip

Funamoto Kenichi, YOSHINO Daisuke, ITO Takuya, SUGIBAYASHI Rika, FUNAMOTO Kiyoe

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2015/04/01 - 2018/03/31

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A placenta-on-a-chip was developed in this study in order to reproduce the structure and function of the microenvironment of a human placenta. Media channels, which model intervillous space and fetal blood vessel, were placed flanking the three parallel gel channels which mimic the extracellular matrix. Gas channels through which gas mixtures are supplied to control the oxygen tension inside the chip were placed above the media channels. A method to form monolayers of human choriocarcinoma cells (JEG3s) and human umbilical vein endothelial cells (HUVECs) in the media channels, and a method to measure the permeability of the monolayers were established. The co-culture of JEG3s and HUVECs under a controlled oxygen tension at different concentrations showed variations of cell morphology and cell junctions, implying that oxygen tension can influence the cell-cell interaction.
Multidisciplinary Approach for Arteriovenous Malformation Based on Computational Fluid Dynamics

Shimizu Hiroaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Akita University

2014/04/01 - 2017/03/31

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Hemodynamics of arteriovenous malformation (AVM) was successfully analyzed using computational fluid dynamics (CFD). Four dimensional magnetic resonance imaging (4D-MRI) was also performed and compared with CFD. Hemodynamic parameters such as wall shear stress and velocity were provide by both CFD and 4D-MRI. However patients who suffered from AVM mostly had severe physical conditions, and it was difficult to create a large database during three years. <BR> On the other hand, the research team developed a new approach for diagnosing the risk factor of the recurrence after coil embolization of cerebral aneurysms. Based on it, a new software to evaluate the risk for coil embolization is under developing. In conclusion, this project became a foundation for the future development of CFD.
Brain protection by local hypothermia in the acute phase of traumatic brain injury

Tominaga Teiji, Endo Toshiki, Saito Ryuta, Nakagawa Atsuhiro, Niizuma Kuniyasu, Sugiyama Shinichiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2014/04/01 - 2016/03/31

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The purpose of this study was to develop new methodology for brain protection. We used convection-enhanced delivery (CFD) to inject low-temperature fluid into damaged tissue in the acute phase of traumatic brain injury. First, we developed magnetic resonance method for real-time monitoring of fluid distribution during the continuous CFD injection. Second, we aimed the proof-of-concept study for the effect of local hypothermia on the damaged brain. In the animal models of traumatic brain injury, it was difficult to perfuse damaged brain tissue with cooling saline because of the rapid elevation of intracranial pressure just after the injury. Though hyperosmotic fluid was reported to be effective in the CFD injection into damaged brain tissue, we could not reproduce the effectiveness of heyperosmotic fluid in our experimental design. In order to make a breakthrough, we are developing the optimal fluid to perfuse the damaged brain tissue.
Prediction of the wall property and rupture risk of cerebral aneurysms based on the computational fluid dynamics

Niizuma Kuniyasu, SUGIYAMA SHIN-ICHIRO, NAKAGAWA ATSUHIRO, HAYASE TOSHIYUKI, OHTA MAKOTO, FUNAMOTO KENICHI, ARAFUNE TATSUHIKO, WASHIO TOSHIKATSU

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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The purpose of this study was to build a large-scale cerebral aneurysm database including computational fluid dynamics (CFD) analysis, and to predict wall property and rupture risk. In the 3 years around 500 cases were included. Based on the database, we reported that the yellowish wall can be predicted by CFD. In addition, we revealed that rupture risk or recanalization after coil embolization could be predicted by CFD. Further analysis based on the database and outpatient clinic system are planned.
Convection-enhanced drug delivery into the spinal cord

SHIN-ICHIRO Sugiyama, ENDO Toshiki, FUNAMOTO Kenichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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Convection-enhanced delivery (CED) is a method for distributing small and large molecules locally in the interstitial space of the spinal cord. Delivering these molecules to the spinal cord is otherwise difficult due to the blood-brain or spinal cord barrier. This study revealed regional distribution of macromolecules in the gray and white matter of the spinal cord. In addition, we developed computational methods to predict drug distribution after CED. Finally, we conducted CED treatment for patients with malignant spinal tumor under the approval of the ethical board in Tohoku University Hospital, and got excellent results.
Blood flow simulation integrated with ultrasonic measurement of small animals

FUNAMOTO Kenichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2009 - 2010

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Feasibility study of ultrasonic-measurement-integrated (UMI) simulation, in which feedback signals are added to the governing equations based on errors between ultrasonic measurement and numerical simulation, was performed to obtain accurate and detailed information of hemodynamics in small animals. Flow channel whose ultrasound image was similar to that of an artery in a small animal was made from PVA gel. By experiments measuring flows in flow channels and real blood flows in mouse carotid artery or in human finger artery, the computational accuracy of UMI simulation was improved, showing the feasibility of in vivo measurement.
Development of blood flow simulation integrated with ultrasonic measurement for small animals

FUNAMOTO Kenichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (Start-up)

Category: Grant-in-Aid for Young Scientists (Start-up)

Institution: Tohoku University

2007 - 2008
数値解析と超音波計測を融合した血流構造の解析

船本健一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業特別研究員奨励費

Category: 特別研究員奨励費

Institution: 東北大学

2004 - 2006

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本研究は、血流の超音波計測と数値シミュレーションを一体化した超音波計測融合シミュレーション技術を確立し、血管内の血流場および血行力学の正確かつ詳細な情報を医療現場に提供することを目的としている。本手法では、計算領域内に定義したフィードバック領域内の複数のフィードバック点において、超音波により計測可能な速度情報(ドプラ速度)を基に、実際の血流場に対する速度場の計算結果の誤差を推定し、それに基づく信号をフィードバックして計算を行う。このフィードバックの適用により、計算結果を実際の流れ場に収束させる。本年度は、これまでの知見に基づき、実際の血流場の状態である3次元非定常流の再現に対する本手法の有用性を検証するため、動脈瘤を有する血管内の実際の血流を模擬した基準解の再現に関する数値実験を行った。実際の超音波計測には時間分解能に制限があり、計算時間刻みに対して粗い時間間隔の計測しか行えない可能性がある。そこで、計測の時間分解能が不十分な場合におけるフィードバック方法について検討した。計測データが得られた時刻のみにフィードバックを行う間欠的な方法により、各タイムステップにおいてフィードバックを適用する方法と同じ計算精度が実現でき、有用であることが明らかとなった。ただし、計測の時間間隔を大きくするのに伴い計算が不安定になり易く、ゲインが比較的小さい場合においても解が振動したり計算が発散したりする現象が見られた。動脈瘤内の速度場の誤差が最小となる条件において本手法の計算精度を評価すると、プローブを動脈瘤と同じ高さに1つ設定した場合に、速度場および圧力場の誤差は29%、58%にまでそれぞれ減少し、プローブを2つ用いると計算精度は一層向上し、誤差は8%、17%にまで減少した。壁せん断応力分布もフィードバックの適用により基準解のものに近づき、例えば平均壁せん断応力の最大値は誤差1%以下の精度で再現できた。

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Teaching Experience 8

Biomechanical Engineering　Tohoku University
Intelligent Mechanosystem Analysis　Tohoku University
Fluid mechanics II　Tohoku University
Fluid mechanics II　Ishinomaki Senshu University
Fluid mechanics I　Ishinomaki Senshu University
創薬分析・理論化学持論　徳島大学
基礎ゼミ　東北大学
医工学概論　東北大学

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Social Activities 4

青森県立弘前高等学校職業人講話

2020/10/09 -
青森県立弘前高等学校職業人講話

2017/10/14 -

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青森県立弘前高等学校1年生対象に、「医工学のおもしろさ」と題して、医工学研究者・大学教員として働くことの意義やその職業に求められる資質・能力等について講演を行った。
サイエンスデイ2013

2013/07/21 -

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研究内容を一般の方、特に小学生を対象にわかり易く説明し、体験してもらう展示を行った。「私たちの体の中では、体じゅうに栄養や酸素を運び、老廃物（体の中のいらないもの）を集めるため、血液が血管の中をかけめぐっています。血液や血管の病気を探したり治したりするために、病院では色々な装置が活躍しています。私たちは、病気をもっと簡単に早く見つけ、そして体に優しく治すための研究をしています。ここでは、体の中の血管の形や、血管の中に入って病気を治すのに使うカテーテルや体の中を映し出す超音波装置を実際に触れてみよう。」
サイエンスデイ2012

2012/07/15 -

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研究内容を一般の方、特に小学生を対象にわかり易く説明し、体験してもらう展示を行った。「病院では色々な装置が病気の診断や治療に活躍しています。私たちは、もっと簡単にそして優しく治せる装置の研究をしています。例えば、カテーテルという細くて柔らかいチューブは、血管の中に入っていって、手が届かないからだの奥底にある病気を治療します。血管のモデルの中にカテーテルを通して、どれだけ速くゴールまで到達できるか挑戦してみよう。さらに、血管のどこに病気があるかわかるかな？迷路血管の中を通って病気までたどり着こう。また、超音波を体にあてることで、目では直接見ることができない体の中を映すことができます。超音波装置を操って、黒い物体の中に隠れているものを探しあててみよう。」

Academic Activities 3

Journal of Fluid Science and Technology

2019/09 - Present

Activity type: Peer review
Journal of Biomechanical Science and Engineering

2018/04/01 - 2022/03/31

Activity type: Peer review
Frontiers in Cell and Developmental Biology

2021/10 - 2022/03

Activity type: Peer review

Other 14

酸素濃度制御マイクロ流体デバイスによるがん微小環境の低酸素応答の解明

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がん組織の内部は、細胞の過剰な増殖により低酸素状態にあるとともに、形成される血管が未熟であるため、酸素濃度の空間的な不均一性や急性の低酸素負荷と再酸素化が発生する。本研究では、3次元微小空間の酸素濃度分布を制御できるマイクロ流体デバイスを用いて生体内のがん微小環境を再現し、がん細胞と血管内皮細胞の挙動と、それらの細胞間の相互作用に対して酸素濃度の時空間的な変化が与える影響を解明する。
傾斜遠心力下の赤血球の摩擦特性に関する流体構造連成解析

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傾斜遠心力を受けて平板上を押し付けられながら移動する赤血球の挙動について流体構造連成解析を行い、実験により得られる摩擦特性との比較を行う。
電場と流れ場の連成シミュレーションに関する研究

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静電噴霧により生成された微粒子水の飛行挙動解析を行うことを目的とし、3次元空間内の静電界および流体の連成解析を実施した。
酸素制御マイクロ流体デバイスを用いた細胞応答の観測

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酸素濃度に依存する細胞と基質間の相互作用を明らかにするため、マイクロ流体デバイス内に培養した細胞を非線形光学顕微鏡により経時的に観察し、細胞の遊走を評価する研究を行っている。
3次元培養下の細胞周囲の酸素濃度を制御するマイクロ流体デバイスの開発

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マイクロ流体デバイスを用いることにより、これまで難しかった培養下の細胞の3次元リアルタイム観察が可能となる。本研究では、細胞周囲の酸素濃度を時間的および空間的に制御しながら細胞実験を行うためのマイクロ流体デバイスを開発している。
生体軟組織内の石灰化検出に関する研究

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乳がんの早期発見を目的に、超音波計測により生体軟組織内の微細石灰化が造影されるメカニズムについてモデル実験を行うと共に、より効果的に石灰化を検出するため超音波の送波方法について検討を行っている。
脳動脈瘤内血流のMR計測融合シミュレーション

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脳動脈瘤の壁面性状に関して、血流解析結果と手術中に得られる臨床所見との比較や、脳動脈瘤内の血流場や血行力学を正確に再現するためのMR計測融合シミュレーションのフィージビリティスタディを行っている。
左心房内血流の数値シミュレーション

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心房の能動的な収縮が欠如し、心房壁が小刻みに振動する心房細動の発症による左心房内の血流場や血行力学の変化について数値シミュレーションによる検討を行っている。
脳腫瘍に対するConvection-Enhanced Delivery (CED)治療の数値シミュレーション

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脳内の腫瘍に対して薬剤を直接投与するCED治療について、効果的に薬剤を送達するための方法について、数値シミュレーションによる検討を行っている。
胎児脳出血の機序の解明と予防法の確立

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小児脳性麻痺の予防を目的に、その主な原因である胎児脳出血に関する動物実験を行っている。小動物の胎仔に対して虚血再還流処置を行い、超音波診断装置や胎児心電図を用いて脳出血の好発部位やタイミングを明らかにし、その予防方法について検討を行っている。
血流のMR計測融合シミュレーション手法の開発

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脳の血管内の血流情報を高分解能かつ高精度に得るため、血流のPhase-Contrast MRIと数値シミュレーションを融合したMR計測融合シミュレーション手法を開発し、脳動脈瘤内の血流場や血行力学を再現する手法を確立した。
2次元超音波計測融合血流解析システムの開発

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臨床応用を目的とした2次元超音波計測融合シミュレーションによる血流可視化システムについて、複数の患者の頚動脈内の血流を解析対象としたフィージビリティスタディを行い、システムの高精度化および汎用化に取り組んでいる。
マイクロバブルを用いた腫瘍内の微小血管構造の可視化と評価

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がんの診断と治療を目的に、マイクロバブルを用いた超音波計測により腫瘍内部の新生血管を含む微小な血管構造の可視化を可能にし、薬剤投与による変化を評価した。
胸部動脈瘤内血流の超音波計測融合シミュレーション

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超音波計測と数値シミュレーションを融合した血流解析（血流の超音波計測融合シミュレーション）により、胸部動脈瘤内の複雑な非定常の血流場および血行力学を正確かつ詳細に再現する手法を開発している。

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