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Kotaro Sena

Section

Graduate School of Dentistry

Job title

Senior Assistant Professor

Degree

博士（歯学）（東京医科歯科大学）

researchmap

https://researchmap.jp/senaperi

J-GLOBAL ID

200901065603158060

e-Rad No.

60701117

ORCID

https://orcid.org/0000-0003-0612-1826

Researcher ID

A-8033-2013

Research History 7

2025/04 - Present

Tohoku University　Graduate School of Dentistry　Senior Assistant Professor
2025/04 - 2025/07

Tohoku University Hospital　Department of Oral Suupprtive Care and Management　Senior Assistant Professor
2022/07 - 2025/03

Tohoku University　Graduate School of Dentistry　Assistant Professor
2013/01 - 2022/06

Kagoshima University　Graduate School of Medical and Dental Sciences　Assistant Professor
2006/07 - 2012/12

Rush University Medical Center　Assistant Professor
2003/10 - 2006/06

Rush University Medical Center　Postdoctoral Fellow
2003/04 - 2003/09

Tokyo Medical and Dental University　University Hospital of Dentistry　Clinical Staff

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Education 2

Tokyo Medical and Dental University　Graduate School of Dentistry

1999/04 - 2003/03
Tokyo Medical and Dental University　Faculty of Dentistry

1993/04 - 1999/03

Committee Memberships 2

東北口腔衛生学会　幹事

2024/11 - Present
仙台市成人歯科健診等マニュアル改訂検討部会　委員

2024/10 - Present

Professional Memberships 9

日本口臭学会
日本がんサポーティブケア学会
Multinational Association of Supportive Care in Cancer
Japanese Association of Oral Supportive Care
Japanese Society for Oral Health
The American Society for Bone and Mineral Research
Tohoku University Dental Society
The Japanese Society of Periodontology
International Association for Dental Research

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Research Interests 6

oral supportive care
orthopedics
tissue engineering
periodontal tissue regeneration
bone biology
periodontology

Research Areas 2

Life sciences / Regenerative dentistry and dental engineering / Periodontal regeneration
Life sciences / Conservative dentistry and endodontics / periodontology

Awards 5

歯学部同窓会奨励賞

2021/11　鹿児島大学歯学部同窓会
日本歯周病学会教育賞受賞

2017/05　日本歯周病学会　歯周基本治療のための新たな教育用模型の開発
Young Investigator Award

2007/12　American Society for Bone and Mineral Research
Sigma Xi Travel Award

2007/02　Sigma Xi Society
Alice L. Jee Memorial Young Investigator Award

2006/08　Sun Valley International Hard Tissue Conference

Papers 42

Elucidation of Factors Affecting Anterior Occlusion in Primary Dentition Based on the Japan Environment and Children's Study. International-journal Peer-reviewed

Risa Ishiko, Kotaro Sena, Ichie Koseki, Masumi Sasai, Chiharu Ota, Takeyoshi Koseki

Children (Basel, Switzerland)　12　(2)　2025/02/19

DOI： 10.3390/children12020254 　

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Background/Objectives: Malocclusion in primary dentition affects permanent dentition. However, the factors contributing to malocclusion in the oral cavities of children have not been fully elucidated. We hypothesized that environmental factors affect malocclusion in the primary dentition of the Japanese population and aimed to identify factors associated with anterior occlusion in primary dentition. Methods: The study involved 3793 parent-child pairs from the Miyagi Regional Centre as part of a supplementary survey to the Japan Environment and Children's Study, a cohort study. A questionnaire assessing oral development and environmental factors was administered to parent-child pairs who consented to participate. Parents assessed anterior occlusion when their children were 3.5 years old. Results: The maxillary primary central incisors tended to erupt earlier in the open bite group. Significantly more children in this group were breastfed until 1 year and drank ionic beverages at 1.5 years. In addition, thumb sucking or pacifier use was significantly common at 2 years of age. A correlation was observed between the mother's body mass index (BMI) before and after pregnancy and anterior occlusion. Conclusions: In the open bite group, the occlusion status of the anterior teeth at 3.5 years of age showed distinctive results influenced by the eruption period of the primary anterior teeth, oral habits, intake of sweetened beverages, and maternal BMI. These findings suggest that parental observation could be useful for screening children for malocclusion until the eruption of permanent dentition.
Development of subgingival calculus detector utilizing optical fiber: Verification of its potential for clinical application Peer-reviewed

Tsubasa Kato, Kotaro Sena, Risa Ishiko, Naoko Tanda, Nobuhiro Yoda, Hiroki Hihara, Takeyoshi Koseki

PLOS ONE　2024/12/03

DOI： 10.1371/journal.pone.0314563 　
Low-Intensity Pulsed Ultrasound Promotes BMP9 Induced Osteoblastic Differentiation in Rat Dedifferentiated Fat Cells. International-journal Peer-reviewed

Fumiaki Setoguchi, Kotaro Sena, Kazuyuki Noguchi

International Journal of Stem Cells　2023/06/30

DOI： 10.15283/ijsc23027 　

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BACKGROUND AND OBJECTIVES: Dedifferentiated fat cells (DFATs) isolated from mature adipocytes have a multilineage differentiation capacity similar to mesenchymal stem cells and are considered as promising source of cells for tissue engineering. Bone morphogenetic protein 9 (BMP9) and low-intensity pulsed ultrasound (LIPUS) have been reported to stimulate bone formation both in vitro and in vivo. However, the combined effect of BMP9 and LIPUS on osteoblastic differentiation of DFATs has not been studied. METHODS AND RESULTS: After preparing DFATs from mature adipose tissue from rats, DFATs were treated with different doses of BMP9 and/or LIPUS. The effects on osteoblastic differentiation were assessed by changes in alkaline phosphatase (ALP) activity, mineralization/calcium deposition, and expression of bone related genes; Runx2, osterix, osteopontin. No significant differences for ALP activity, mineralization deposition, as well as expression for bone related genes were observed by LIPUS treatment alone while treatment with BMP9 induced osteoblastic differentiation of DFATs in a dose dependent manner. Further, co-treatment with BMP9 and LIPUS significantly increased osteoblastic differentiation of DFATs compared to those treated with BMP9 alone. In addition, upregulation for BMP9-receptor genes was observed by LIPUS treatment. Indomethacin, an inhibitor of prostaglandin synthesis, significantly inhibited the synergistic effect of BMP9 and LIPUS co-stimulation on osteoblastic differentiation of DFATs. CONCLUSIONS: LIPUS promotes BMP9 induced osteoblastic differentiation of DFATs in vitro and prostaglandins may be involved in this mechanism.
COVID-19 and periodontal disease

Kotaro Sena, Kazuyuki Noguchi

日本歯周病学会会誌(Web)　65　(2)　2023

ISSN： 1880-408X
Comparison of periodontal wound healing/regeneration by recombinant human fibroblast growth factor-2 combined with β-tricalcium phosphate, carbonate apatite, or deproteinized bovine bone mineral in a canine one-wall intra-bony defect model. International-journal Peer-reviewed

Yoshinori Shirakata, Fumiaki Setoguchi, Kotaro Sena, Toshiaki Nakamura, Takatomo Imafuji, Yukiya Shinohara, Masayuki Iwata, Kazuyuki Noguchi

Journal of Clinical Periodontology　49　(6)　599-608　2022/06

DOI： 10.1111/jcpe.13619 　

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AIM: To evaluate periodontal wound healing/regeneration of one-wall intra-bony defects treated with recombinant human fibroblast growth factor-2 (rhFGF-2) and beta-tricalcium phosphate (β-TCP), carbonate apatite (CO3 Ap), or deproteinized bovine bone mineral (DBBM) in dogs. MATERIALS AND METHODS: The stability of rhFGF-2 adsorbed onto the bone substitutes was evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). One-wall intra-bony defects (5 × 5 × 5 mm) created in five adult male beagle dogs were treated with rhFGF-2 alone (rhFGF-2), rhFGF-2 with β-TCP (rhFGF-2/β-TCP), rhFGF-2 with CO3 Ap (rhFGF-2/CO3 Ap), or rhFGF-2 with DBBM (rhFGF-2/DBBM). Histological outcomes (e.g., linear length of new cementum adjacent to the newly formed bone with inserting collagen fibres [NA] as the primary outcome) were evaluated at 10 weeks post surgery. RESULTS: Significantly higher amount of rhFGF-2 was adsorbed onto CO3 Ap compared with β-TCP. Among the treatment groups, the rhFGF-2/DBBM group showed the highest amount of periodontal tissue regeneration. The rhFGF-2/DBBM group showed significantly greater formation of NA (3.22 ± 0.40 mm) compared with rhFGF-2 (1.17 ± 1.00 mm, p < .01) group. Additionally, new bone area in the rhFGF-2/DBBM group (9.78 ± 2.30 mm2 ) was significantly higher than that in the rhFGF-2 (5.08 ± 1.26 mm2 , p < .01), rhFGF-2/β-TCP (5.91 ± 1.27 mm2 , p < .05), and rhFGF-2/CO3 Ap (6.51 ± 1.49 mm2 , p < .05) groups. Slight ankylosis was found in the rhFGF-2/β-TCP (1/9 sites), rhFGF-2/CO3 Ap (3/10 sites), and rhFGF-2/DBBM (1/9 sites) groups. CONCLUSIONS: Within their limitations, the present data indicate that DBBM seems to be a suitable carrier for rhFGF-2 and that rhFGF-2/DBBM treatment promotes favourable periodontal regeneration compared with rhFGF-2, rhFGF-2/β-TCP, and rhFGF-2/CO3 Ap treatments in one-wall intra-bony defects.
Altered expression of SARS-CoV-2 entry and processing genes by Porphyromonas gingivalis-derived lipopolysaccharide, inflammatory cytokines and prostaglandin E2 in human gingival fibroblasts. International-journal Peer-reviewed

Kotaro Sena, Kirara Furue, Fumiaki Setoguchi, Kazuyuki Noguchi

Archives of Oral Biology　129　105201-105201　2021/09
Publisher: Elsevier {BV}
DOI： 10.1016/j.archoralbio.2021.105201 　

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OBJECTIVE: The aim of this in vitro study was to investigate the expression of SARS-CoV-2 entry and processing genes in human gingival fibroblasts (HGnF) following treatment with Porphyromonas gingivalis-derived lipopolysaccharide (PgLPS) or inflammatory cytokines/mediators. DESIGN: We assessed the expression of SARS-CoV-2 entry and processing genes; angiotensin-converting enzyme 2 (ACE2), cellular serine proteases transmembrane serine protease 2 (TMPRSS2), Furin, and basigin (BSG) in HGnF by real-time PCR. To further asses the contribution of PgLPS and inflammatory cytokines/mediators to proliferation and SARS-CoV-2 entry and processing gene expression, HGnF were treated with PgLPS, IL1β, TNFα, and PGE2. RESULTS: The expression for ACE2 in HGnF was significantly elevated after PgLPS or IL1β, TNFα, PGE2 treatment. The expression of TMPRSS2 was increased by PgLPS, IL1β, or PGE2 while BSG was elevated by PgLPS and IL1β. The expression of BSG and FURIN decreased after TNFα treatment. CONCLUSION: SARS-CoV-2 entry and processing genes are expressed in human gingival fibroblasts and their expressions are altered by PgLPS, IL1β, TNFα and PGE2 treatment.
Histological Evaluation of Gingival and Intrabony Periodontal Defects Treated with Platelet-rich Fibrin Using Different Protocols: A Canine Study. International-journal Peer-reviewed

Yoshinori Shirakata, Kotaro Sena, Toshiaki Nakamura, Yukiya Shinohara, Takatomo Imafuji, Fumiaki Setoguchi, Kazuyuki Noguchi, Tomoyuki Kawase, Richard J Miron

Oral health & preventive dentistry　19　(1)　537-546　2021/01/07

DOI： 10.3290/j.ohpd.b2182985 　

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PURPOSE: To histologically compare the effects of platelet-rich fibrin (PRF) produced using different protocols on periodontal wound healing/regeneration in periodontal defects in dogs. MATERIALS AND METHODS: Dehiscence-type gingival recession and two-wall intrabony defects were created bilaterally in the maxillary canines and mandibular premolars, respectively, in four beagle dogs. The recession defects were randomly treated with coronally advanced flap (CAF) alone, CAF and PRF produced via fixed-angle centrifugation (F-PRF; Leukocyte and PRF (L-PRF) protocol) or CAF and PRF produced via horizontal centrifugation (H-PRF). After 2 weeks, the two-wall intrabony defects were randomly treated as follows: open flap debridement (OFD), OFD + F-PRF, OFD + H-PRF and OFD + heated albumin with PRF using bio-heat technologies (Alb-PRF). Eight weeks after the 2nd reconstructive surgery, the animals were euthanised for histological evaluation. RESULTS: In the PRF-applied defects, new bone and new cementum formation occurred to varying degrees regardless of the protocols used to produce PRF. Particularly in the two-wall intrabony defects, new bone formation extended from the host bone toward the coronal region of the defects in the H-PRF applied sites compared with those in the OFD, F-PRF and Alb-PRF groups, and the H-PRF group showed the greatest amount of newly formed cementum. CONCLUSION: PRF induced periodontal regeneration in gingival recession and two-wall intrabony defects in dogs. Further studies are needed to determine the optimal protocol for obtaining predictable periodontal regeneration in periodontal defects in humans.
Periodontal tissue regeneration after low-intensity pulsed ultrasound stimulation with or without intra-marrow perforation in two-wall intra-bony defects-A pilot study in dogs. International-journal Peer-reviewed

Yoshinori Shirakata, Takatomo Imafuji, Kotaro Sena, Yukiya Shinohara, Toshiaki Nakamura, Kazuyuki Noguchi

Journal of clinical periodontology　47　(1)　54-63　2020/01

DOI： 10.1111/jcpe.13197 　

ISSN： 0303-6979

eISSN： 1600-051X
歯周基本治療のための新たな教育用模型の開発

町頭三保, 中村利明, 白方良典, 中村梢, 迫田賢二, 瀬名浩太郎, 篠原敬哉, 橋口千琴, 田口洋一郎, 梅田誠, 野口和行

日本歯周病学会会誌　60　(1)　44-51　2018/03
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
Periodontal wound healing following reciprocal autologous root transplantation in class III furcation defects. International-journal Peer-reviewed

Naoshi Takeuchi, Yoshinori Shirakata, Yukiya Shinohara, Kotaro Sena, Kazuyuki Noguchi

Journal of periodontal & implant science　47　(6)　352-362　2017/12/31

DOI： 10.5051/jpis.2017.47.6.352 　

ISSN： 2093-2278

eISSN： 2093-2286
Healing of two-wall intra-bony defects treated with a novel EMD-liquid-A pre-clinical study in monkeys. International-journal Peer-reviewed

Yoshinori Shirakata, Richard J Miron, Yukiya Shinohara, Toshiaki Nakamura, Kotaro Sena, Naoto Horai, Dieter D Bosshardt, Kazuyuki Noguchi, Anton Sculean

Journal of clinical periodontology　44　(12)　1264-1273　2017/12

DOI： 10.1111/jcpe.12825 　

ISSN： 0303-6979

eISSN： 1600-051X
Involvement of the phosphoinositide 3-kinase/Akt signaling pathway in bone morphogenetic protein 9-stimulated osteogenic differentiation and stromal cell-derived factor 1 production in human periodontal ligament fibroblasts. International-journal Peer-reviewed

Kirara Furue, Kotaro Sena, Kenji Sakoda, Toshiaki Nakamura, Kazuyuki Noguchi

European journal of oral sciences　125　(2)　119-126　2017/04

DOI： 10.1111/eos.12336 　

ISSN： 0909-8836

eISSN： 1600-0722
Effects of EMD liquid (Osteogain) on periodontal healing in class III furcation defects in monkeys. International-journal Peer-reviewed

Yoshinori Shirakata, Richard J Miron, Toshiaki Nakamura, Kotaro Sena, Yukiya Shinohara, Naoto Horai, Dieter D Bosshardt, Kazuyuki Noguchi, Anton Sculean

Journal of clinical periodontology　44　(3)　298-307　2017/03

DOI： 10.1111/jcpe.12663 　

ISSN： 0303-6979

eISSN： 1600-051X
Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models. International-journal Peer-reviewed

Meghan M Moran, Kotaro Sena, Margaret A McNulty, D R Sumner, Amarjit S Virdi

BoneKEy reports　5　837-837　2016/09/07

DOI： 10.1038/bonekey.2016.61 　

ISSN： 2047-6396
歯周組織再生におけるin situ tissue engineering approachを再考する

白方良典, 中村利明, 瀬名浩太郎, 篠原敬哉, 野口和行

九州歯科学会雑誌　70　(3)　57-67　2016/09
Publisher: 九州歯科学会
ISSN： 0368-6833

eISSN： 1880-8719
Recombinant human bone morphogenetic protein-9 potently induces osteogenic differentiation of human periodontal ligament fibroblasts. International-journal Peer-reviewed

Sawako Fuchigami, Toshiaki Nakamura, Kirara Furue, Kotaro Sena, Yukiya Shinohara, Kazuyuki Noguchi

European journal of oral sciences　124　(2)　151-7　2016/04

DOI： 10.1111/eos.12249 　

ISSN： 0909-8836

eISSN： 1600-0722
Healing of localized gingival recessions treated with a coronally advanced flap alone or combined with an enamel matrix derivative and a porcine acellular dermal matrix: a preclinical study Peer-reviewed

Y. Shirakata, A. Sculean, Y. Shinohara, K. Sena, N. Takeuchi, D. D. Bosshardt, K. Noguchi

Clinical Oral Investigations　20　(7)　1791-1800　2015/11/27
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00784-015-1680-4 　

ISSN： 1432-6981

eISSN： 1436-3771
Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation. International-journal Peer-reviewed

Meghan M Moran, Amarjit S Virdi, Kotaro Sena, Steven R Mazzone, Margaret A McNulty, Dale R Sumner

Journal of orthopaedic research : official publication of the Orthopaedic Research Society　33　(9)　1374-81　2015/09

DOI： 10.1002/jor.22901 　

ISSN： 0736-0266

eISSN： 1554-527X
Sclerostin antibody treatment improves implant fixation in a model of severe osteoporosis. International-journal Peer-reviewed

Amarjit S Virdi, John Irish, Kotaro Sena, Min Liu, Hua Zhu Ke, Margaret A McNulty, Dale R Sumner

The Journal of bone and joint surgery. American volume　97　(2)　133-40　2015/01/21

DOI： 10.2106/JBJS.N.00654 　

ISSN： 0021-9355

eISSN： 1535-1386
Cytotoxic effects of cobalt and nickel ions on osteocytes in vitro. International-journal Peer-reviewed

Arihiko Kanaji, Vbenosawemwinghaye Orhue, Marco S Caicedo, Amarjit S Virdi, Dale R Sumner, Nadim J Hallab, Toyama Yoshiaki, Kotaro Sena

Journal of orthopaedic surgery and research　9　91-91　2014/10/08

DOI： 10.1186/s13018-014-0091-6 　

ISSN： 1749-799X
Combined use of low-intensity pulsed ultrasound and rhBMP-2 to enhance bone formation in a rat model of critical size defect. International-journal Peer-reviewed

Siddhesh R Angle, Kotaro Sena, Dale R Sumner, Walter W Virkus, Amarjit S Virdi

Journal of orthopaedic trauma　28　(10)　605-11　2014/10/01

DOI： 10.1097/BOT.0000000000000067 　

ISSN： 0890-5339

eISSN： 1531-2291
Bone matrix quality after sclerostin antibody treatment. International-journal Peer-reviewed

Ryan D Ross, Lindsey H Edwards, Alvin S Acerbo, Michael S Ominsky, Amarjit S Virdi, Kotaro Sena, Lisa M Miller, D Rick Sumner

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research　29　(7)　1597-607　2014/07/01

DOI： 10.1002/jbmr.2188 　

ISSN： 0884-0431

eISSN： 1523-4681
Particle‐induced osteolysis is not accompanied by systemic remodeling but is reflected by systemic bone biomarkers Peer-reviewed

R.D. Ross, A.S. Virdi, S. Liu, K. Sena, D.R. Sumner

Journal of Orthopaedic Research　32　(7)　967-973　2014/03/06
Publisher: Wiley
DOI： 10.1002/jor.22607 　

ISSN： 0736-0266

eISSN： 1554-527X

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ABSTRACT Particle‐induced osteolysis is caused by an imbalance in bone resorption and formation, often leading to loss of implant fixation. Bone remodeling biomarkers may be useful for identification of osteolysis and studying pathogenesis, but interpretation of biomarker data could be confounded if local osteolysis engenders systemic bone remodeling. Our goal was to determine if remote bone remodeling contributes to biomarker levels. Serum concentrations of eight biomarkers and bone remodeling rates at local (femur), contiguous (tibia), and remote (humerus and lumbar vertebra) sites were evaluated in a rat model of particle‐induced osteolysis. Serum CTX‐1, cathepsin K, PINP, and OPG were elevated and osteocalcin was suppressed in the osteolytic group, but RANKL, TRAP 5b, and sclerostin were not affected at the termination of the study at 12 weeks. The one marker tested longitudinally (CTX‐1) was elevated by 3 weeks. We found increased bone resorption and decreased bone formation locally, subtle differences in contiguous sites, but no differences remotely at 12 weeks. Thus, the skeletal response to local particle challenge was not systemic, implying that the observed differences in serum biomarker levels reflect differences in local remodeling. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:967–973, 2014.
Implant placement increases bone remodeling transiently in a rat model. International-journal Peer-reviewed

John Irish, Amarjit S Virdi, Kotaro Sena, Margaret A McNulty, Dale R Sumner

Journal of orthopaedic research : official publication of the Orthopaedic Research Society　31　(5)　800-6　2013/05

DOI： 10.1002/jor.22294 　

ISSN： 0736-0266
Bone Regeneration Varies in Four Different Mouse Strains after Marrow Ablation Peer-reviewed

Meghan Moran, Amarjit S. Virdi, Kotaro Sena, Margaret A. McNulty, D. R. Sumner

JOURNAL OF BONE AND MINERAL RESEARCH　28　2013/02

ISSN： 0884-0431

eISSN： 1523-4681
Remote Remodeling Does Not Contribute to Systemic Differences in Biomarkers Following Local Skeletal Insult Peer-reviewed

Ryan Ross, Amarjit Virdi, Shou Liu, Kotaro Sena, D. Rick Sumner

JOURNAL OF BONE AND MINERAL RESEARCH　28　2013/02

ISSN： 0884-0431

eISSN： 1523-4681
Sclerostin antibody prevents particle-induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model. International-journal Peer-reviewed

Shuo Liu, Amarjit S Virdi, Kotaro Sena, Dale R Sumner

Arthritis and rheumatism　64　(12)　4012-20　2012/12/01

DOI： 10.1002/art.37697 　

ISSN： 0004-3591
Sclerostin antibody increases bone volume and enhances implant fixation in a rat model. International-journal Peer-reviewed

Amarjit S Virdi, Min Liu, Kotaro Sena, James Maletich, Margaret McNulty, Hua Zhu Ke, Dale R Sumner

The Journal of bone and joint surgery. American volume　94　(18)　1670-80　2012/09/19

DOI： 10.2106/jbjs.k.00344 　

ISSN： 0021-9355

eISSN： 1535-1386
Adult stem cell mobilization enhances intramembranous bone regeneration: a pilot study. International-journal Peer-reviewed

Margaret A McNulty, Amarjit S Virdi, Kent W Christopherson, Kotaro Sena, Robin R Frank, Dale R Sumner

Clinical orthopaedics and related research　470　(9)　2503-12　2012/09/01

DOI： 10.1007/s11999-012-2357-9 　

ISSN： 0009-921X

eISSN： 1528-1132
Bone turnover markers correlate with implant fixation in a rat model using LPS-doped particles to induced implant loosening. International-journal Peer-reviewed

Shuo Liu, Amarjit S Virdi, Kotaro Sena, W Frank Hughes, Dale R Sumner

Journal of biomedical materials research. Part A　100　(4)　918-28　2012/04

DOI： 10.1002/jbm.a.34029 　

ISSN： 1549-3296

eISSN： 1552-4965
Healing of rat femoral segmental defect with bone morphogenetic protein-2: a dose response study. International-journal Peer-reviewed

Kotaro Sena

Journal of musculoskeletal & neuronal interactions　12　(1)　28-37　2012/03/01

ISSN： 1108-7161

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<h4>Objective</h4>Use of recombinant human bone morphogenetic protein-2 (rhBMP-2) is becoming a common clinical approach to enhance bone repair. There is little or no information in the literature on the dose of rhBMP-2 required for effective healing of critical-sized defects such as those associated with trauma. In this study, we used a segmental defect model to assess the dose response of rhBMP-2 using quantitative and qualitative endpoints.<h4>Methods</h4>Femoral defects in rats were replaced with absorbable collagen sponges carrying rhBMP-2 (0, 1, 5, 10 or 20 μg; N=5). At 4-weeks new bone formation was assessed using quantitative (radiography and microcomputed tomography) and qualitative (histology and backscattered-SEM) endpoints statistically compared.<h4>Results</h4>rhBMP-2 showed increased bridging in the gap. Quantitative evaluation presented a bi-phasic dose response curve. Histological assessment revealed that with rhBMP-2 the defect showed the presence of spongy bone with the trabeculae layered with active osteoblasts and osteoclasts. The density and compactness of the bone varied with the dose of rhBMP-2.<h4>Conclusions</h4>Our findings revealed that all doses of rhBMP-2 result in new bone formation. However, there is an optimum dose of 12 μg of rhBMP-2 for bone repair in this model, above which and below which less stimulation of bone occurs.
Calcineurin/nuclear factor of activated T cells (NFAT) signaling in cobalt-chromium-molybdenum (CoCrMo) particles-induced tumor necrosis factor-α (TNFα) secretion in MLO-Y4 osteocytes. International-journal Peer-reviewed

Vbenosawemwinghaye Orhue, Arihiko Kanaji, Marco S Caicedo, Amarjit S Virdi, Dale R Sumner, Nadim J Hallab, Holger Jahr, Kotaro Sena

Journal of orthopaedic research : official publication of the Orthopaedic Research Society　29　(12)　1867-73　2011/12

DOI： 10.1002/jor.21458 　

ISSN： 0736-0266

eISSN： 1554-527X
Low-intensity pulsed ultrasound (LIPUS) and cell-to-cell communication in bone marrow stromal cells. International-journal Peer-reviewed

Kotaro Sena, Siddhesh R Angle, Arihiko Kanaji, Chetan Aher, David G Karwo, Dale R Sumner, Amarjit S Virdi

Ultrasonics　51　(5)　639-44　2011/07

DOI： 10.1016/j.ultras.2011.01.007 　

ISSN： 0041-624X
Osteogenic differentiation of rat bone marrow stromal cells by various intensities of low-intensity pulsed ultrasound Peer-reviewed

Siddhesh R Angle, Kotaro Sena, Dale R Sumner, Amarjit S Virdi

Ultrasonics　51　(3)　281-288　2011/04
Publisher: Elsevier BV
DOI： 10.1016/j.ultras.2010.09.004 　

ISSN： 0041-624X
Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration. International-journal Peer-reviewed

Joel K Wise, Kotaro Sena, Karen Vranizan, Jacob F Pollock, Kevin E Healy, W Frank Hughes, D Rick Sumner, Amarjit S Virdi

PloS one　5　(10)　2010/10/01

DOI： 10.1371/journal.pone.0012987 　

ISSN： 1932-6203
Effect of recombinant human transforming growth factor-beta2 dose on bone formation in rat femur titanium implant model. International-journal Peer-reviewed

Kotaro Sena, Dale R Sumner, Amarjit S Virdi

Journal of biomedical materials research. Part A　92　(3)　1210-7　2010/03/01

DOI： 10.1002/jbm.a.32461 　

ISSN： 1549-3296

eISSN： 1552-4965
Ultrasound enhances recombinant human BMP-2 induced ectopic bone formation in a rat model. International-journal Peer-reviewed

Coen A Wijdicks, Amarjit S Virdi, Kotaro Sena, Dale R Sumner, Robert M Leven

Ultrasound in medicine & biology　35　(10)　1629-37　2009/10

DOI： 10.1016/j.ultrasmedbio.2009.04.017 　

ISSN： 0301-5629

eISSN： 1879-291X
Co-Cr-Mo alloy particles induce tumor necrosis factor alpha production in MLO-Y4 osteocytes: a role for osteocytes in particle-induced inflammation. International-journal Peer-reviewed

Arihiko Kanaji, Marco S Caicedo, Amarjit S Virdi, D Rick Sumner, Nadim J Hallab, Kotaro Sena

Bone　45　(3)　528-33　2009/09

DOI： 10.1016/j.bone.2009.05.020 　

ISSN： 8756-3282

eISSN： 1873-2763
Modulation of VEGF expression in rat bone marrow stromal cells by GDF-5. International-journal Peer-reviewed

Kotaro Sena, Dale R Sumner, Amarjit S Virdi

Connective tissue research　48　(6)　324-31　2007/01/01

DOI： 10.1080/03008200701692743 　

ISSN： 0300-8207

eISSN： 1607-8438
Biomimetic artificial ECMs stimulate bone regeneration. International-journal Peer-reviewed

Eugene H Chung, Michele Gilbert, Amarjit S Virdi, Kotaro Sena, Dale R Sumner, Kevin E Healy

Journal of biomedical materials research. Part A　79　(4)　815-26　2006/12/15

DOI： 10.1002/jbm.a.30809 　

ISSN： 1549-3296
Early gene response to low-intensity pulsed ultrasound in rat osteoblastic cells. International-journal Peer-reviewed

Kotaro Sena, Robert M Leven, Khurram Mazhar, Dale R Sumner, Amarjit S Virdi

Ultrasound in medicine & biology　31　(5)　703-8　2005/05/01

DOI： 10.1016/j.ultrasmedbio.2005.01.013 　

ISSN： 0301-5629
Gene Expression of Growth Differentiation Factors in the Developing Periodontium of Rat Molars Peer-reviewed

Kotaro Sena, Yoko Morotome, Otto Baba, Tatsuo Terashima, Yoshiro Takano, Isao Ishikawa

Journal of Dental Research　82　(3)　166-171　2003/03
Publisher: SAGE Publications
DOI： 10.1177/154405910308200304 　

ISSN： 0022-0345

eISSN： 1544-0591

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Growth and differentiation factors (GDF) 5, 6, and 7 are known to play roles in tendon and ligament formation, and are therefore probably involved in the formation of periodontal ligament. In this study, we sought to determine temporal and spatial expression of GDF-5, -6, and -7 mRNA in developing periodontal tissue of rat molars using in situ hybridization. GDF gene expression in the periodontal ligament was first detected in cells associated with the initial process of periodontal ligament fiber bundle formation. Gene signals were also detected in cells located along the alveolar bone and cementum surfaces, the insertion sites of periodontal ligaments, during the course of root formation. GDF expression in these cells were down-regulated after completion of root formation. Our results appeared to suggest the involvement of GDF-5, -6, and -7 in the formation of the dental attachment apparatus.

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Misc. 26

光ファイバーを用いた歯石検出装置の開発と臨床応用の可能性

瀬名浩太郎, 加藤翼, 石河理紗, 石河理紗, 丹田奈緒子, 丹田奈緒子, 小関健由

口腔衛生学会雑誌　75　2025

ISSN： 0023-2831
免疫チェックポイント阻害薬の口腔粘膜炎に関する観察研究

浅野千絵, 上野尚雄, 八岡和歌子, 瀬名浩太郎, 石河理紗, 丹田奈緒子, 小関健由

口腔衛生学会雑誌　75　2025

ISSN： 0023-2831
保育園・こども園と幼稚園間のう蝕経験に関わるリスク要因の差異について

加藤翼, 瀬名浩太郎, 百々美奈, 石河理紗, 丹田奈緒子, 小関健由

日本歯科医療管理学会雑誌　59　(1)　2024

ISSN： 0387-5687
化学療法中の抜歯に関して円滑な病診連携,医科歯科連携が実施された症例

石河理紗, 瀬名浩太郎, 瀬名浩太郎, 百々美奈, 加藤翼, 丹田奈緒子, 丹田奈緒子, 小関健由

日本歯科医療管理学会雑誌　59　(1)　2024

ISSN： 0387-5687
自習にて初等プロービング実習を推進するプロービング学習法について

笹井真澄, 瀬名浩太郎, 石河理沙, 加藤翼, 丹田奈緒子, 小関健由

口腔衛生学会雑誌　74　2024

ISSN： 0023-2831
頭頸部癌皮弁移植術前にアムホテリシンB耐性を有する稀少カンジダ感染を生じた1例

石河理紗, 瀬名浩太郎, 瀬名浩太郎, 加藤翼, 笹井真澄, 丹田奈緒子, 小関健由

口腔衛生学会雑誌　74　2024

ISSN： 0023-2831
新型コロナウイルス感染症の流行ががん口腔支持療法受診に及ぼす影響

瀬名浩太郎, 石河理紗, 丹田奈緒子, 百々美奈, 加藤翼, 小関健由

口腔衛生学会雑誌　73　(増刊)　204-204　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
青年期の口腔保健行動に関する行動・意識調査とう蝕経験について

丹田奈緒子, 瀬名浩太郎, 百々美奈, 石河理紗, 加藤翼, 小関健由

みちのく齒學會雑誌　54　(1-2)　2023

ISSN： 0385-0099
周術期等口腔管理に対する患者意識や歯科受診における質問紙調査

百々美奈, 石河理紗, 加藤翼, 瀬名浩太郎, 丹田奈緒子, 小関健由

みちのく歯学会雑誌　53　(1-2)　84-84　2022/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
低出力超音波パルスはBMP9により誘導された脱分化脂肪細胞の骨芽細胞様分化を増強する

瀬戸口史晃, 瀬名浩太郎, 野口和行

日本歯周病学会会誌　64　(秋季特別)　128-128　2022/08
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
βリン酸三カルシウム、炭酸アパタイトおよび脱タンパク牛骨ミネラルとリグロス併用による歯周組織再生効果イヌ1壁性骨欠損モデルにおける組織学的比較評価

白方良典, 瀬名浩太郎, 今藤隆智, 中村利明, 篠原敬哉, 瀬戸口史晃, 岩田真行, 野口和行

日本歯周病学会会誌　64　(春季特別)　117-117　2022/05
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
低出力超音波パルスはBMP9により誘導された脱分化脂肪細胞の骨芽細胞様分化を増強する

瀬戸口史晃, 瀬名浩太郎, 野口和行

日本歯周病学会会誌(Web)　64　2022

ISSN： 1880-408X
Development of a new model for training of initial periodontal therapy

町頭三保, 中村利明, 白方良典, 中村梢, 迫田賢二, 瀬名浩太郎, 篠原敬哉, 橋口千琴, 田口洋一郎, 梅田誠, 野口和行

日本歯周病学会会誌(Web)　60　(1)　2018

ISSN： 1880-408X
サル根岐部病変III度に対するOsteogainと吸収性コラーゲンスポンジを用いた歯周組織再生

白方良典, 瀬名浩太郎, 中村利明, 篠原敬哉, 寶来直人, 野口和行

日本歯周病学会会誌　58　(秋季特別)　110-110　2016/09
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
歯周基本治療のための新たな教育用模型の開発

町頭三保, 中村利明, 白方良典, 中村梢, 迫田賢二, 瀬名浩太郎, 篠原敬哉, 橋口千琴, 岩城重次, 大西和久, 野口和行

日本歯周病学会会誌　58　(秋季特別)　120-120　2016/09
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
Porphyromonas gingivalis由来lipopolysaccharideの骨細胞への影響

瀬名浩太郎, 古江きらら, 野口和行

日本歯周病学会会誌　58　(春季特別)　118-118　2016/04
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
Reconsideration of an in situ tissue engineering approach in periodontal regenerative therapy

白方良典, 中村利明, 瀬名浩太郎, 篠原敬哉, 野口和行

九州歯科学会雑誌(Web)　70　(3)　2016

ISSN： 1880-8719
サル根岐部病変III度に対するOsteograinと吸収性コラーゲンスポンジを用いた歯周組織再生

白方良典, 瀬名浩太郎, 中村利明, 篠原敬哉, 寶来直人, 野口和行

日本歯周病学会会誌(Web)　58　2016

ISSN： 1880-408X
BMP-9はヒト歯根膜線維芽細胞の新規の骨芽細胞様分化因子である

渕上佐和子, 中村利明, 篠原敬哉, 瀬名浩太郎, 古江きらら, 野口和行

特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集　140回　83-83　2014/06
Publisher: (NPO)日本歯科保存学会
Bone Morphogenetic Protein 9による骨芽細胞の分化

古江きらら, 瀬名浩太郎, 武内博信, 中村利明, 野口和行

日本歯周病学会会誌　56　(春季特別)　109-109　2014/04
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
歯周病学分野での研究について

野口和行, 松山孝司, 町頭三保, 白方良典, 中村利明, 長谷川梢, 吉元剛彦, 迫田賢二, 武内博信, 立石ふみ, 瀬名浩太郎, 谷山勝義, 下田平直大

鹿児島大学歯学部紀要　33　83-85　2013
Publisher: 鹿児島大学
Adult Stem Cell Mobilization to Enhance Intramembranous Bone Regeneration in the Mouse

Margaret A. McNulty, Kent W. Christopherson, Amarjit S. Virdi, Kotaro Sena, Robin R. Frank, Dale R. Sumner

FASEB JOURNAL　26　2012/04

ISSN： 0892-6638
Stimulation of osteogenic differentiation by growth and differentiation factor-5 in rat adult bone marrow stromal cells.

K. Sena, D. R. Sumner, A. S. Virdi

JOURNAL OF BONE AND MINERAL RESEARCH　21　S211-S211　2006/09

ISSN： 0884-0431
Effect of recombinant human transforming growth factor-beta2 dose on bone formation in rat femur titanium implant model.

K Sena, AS Virdi, DR Sumner

JOURNAL OF BONE AND MINERAL RESEARCH　20　(9)　S131-S131　2005/09

ISSN： 0884-0431
ラット臼歯の歯根形成期におけるGDF-7(Growth/Differentiation Factor/7)遺伝子の発現

瀬名浩太郎, 諸留よう子[林], 馬場麻人, 寺島達夫, 石川烈

日本歯周病学会会誌　42　(秋季特別)　140-140　2000/09
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
歯周組織再生のパラダイムサイトカイン療法vsバリヤー療法 Attachment apparatus再生メカニズムへの推察

諸留よう子[林], 瀬名浩太郎, 岩田隆紀, 馬場麻人, 寺島達夫, 石川烈

日本歯周病学会会誌　42　(秋季特別)　62-62　2000/09
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X

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Research Projects 14

Novel periodontal tissue regeneration treatment based on cell-free treatment using stem cell extracts.

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Osaka Dental University

2024/04/01 - 2027/03/31
化学療法誘発性末梢神経障害の実態解明およびリスク・増悪因子の検索

石河理紗, 瀬名浩太郎, 小関健由

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2023/04/01 - 2026/03/31
Development of periodontal tissue regeneration therapy for diabetic patients using LIPUS and BMP9

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kagoshima University

2022/04/01 - 2025/03/31
Development of novel intraoral photobiomodulation therapy device for oral mucosal disorders in cancer patients

Kotaro Sena, Risa Ishiko, Tsubasa Kato

Offer Organization: Tohoku University Hospital

System: The Clinical Research Promotion Program for Young Investigators of Tohoku University Hospital

2023/06 - 2025/03
GDF6 in Periodontal Tissue Repair and Regeneration

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kagoshima University

2021/04/01 - 2024/03/31
バクテリオファージを用いたARONJに対する新規治療法の創出

比地岡浩志, 岩野英知, 松尾美樹, 瀬名浩太郎, 後藤雄一, 久米健一, 杉浦剛

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 鹿児島大学

2020/04/01 - 2023/03/31

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ARONJは難治性かつ進行性の慢性炎症性疾患で未だに病態は不明なことが多く、治療法も確立していない。細菌感染がその発症、進展に重要な役割を果たしていることは明らかであるが、その原因となる菌種等は同定されていない。今年度は歯周病原因菌であり、ARONJにも深く関わっていると思われるStreptococcus gordoniiに対して毒性のあるファージを単離することを試み、以下の研究結果を得た。S. gordoniiに対する毒性バクテリオファージ（ΦSG005）は当院歯科排水溝から採取された廃液中に発見された。ΦSG005は電子顕微鏡分析によってポドウイルス科の特徴である短く非収縮性の尾と長頭の構成を認め、turbidity reduction assayにおいて、S.gordoniiに対して効率的な殺菌効果を示した。また全ゲノム配列決定により、21のコード配列を持つ16,127bpのDNAゲノムを持っていることが示された。ΦSG005ゲノムにインテグラーゼなどのプロファージ関連要素は同定されておらず、ウイルスが毒性のあるファージであることを示した。系統発生分析は、ΦSG005が連鎖球菌ウイルスの中で明確なクレードを形成し、連鎖球菌ウイルスC1の隣に位置していることを示し、分子特性はΦSG005ゲノムに抗CRISPR（Acr）IIA5様タンパク質が存在することを明らかにした。これらの発見はストレプトコッカスウイルスの理解を促し、歯周病やARONJなどS. gordonii感染が関わっている疾患に対するファージ療法の開発に貢献すると考えられた。
Development of novel periodontal/bone regenerative therapy utilizing LIPUS, BMP9, and dedifferentiated fat cells

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kagoshima University

2019/04/01 - 2022/03/31
GDF6 in Aging of Periodontal Tissue

Sena Kotaro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kagoshima University

2018/04/01 - 2021/03/31

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Aging is a phenomenon that affects all tissues in the body and causes deterioration in maintaining tissue homeostasis and wound healing ability. At present, most studies related to periodontal tissue regeneration have rarely verified the effect of aging in regenerated tissues and individuals. In this study, we analyzed whether the expression of growth differentiation factor 6 (GDF6), which is one of the growth factors expressed in periodontal tissue, is affected by the aging of human periodontal ligament cells and the expression of proteins related to aging. From this study, it is considered that GDF6 is involved in the aging of periodontal tissue.
The development of novel periodontal regenerative therapy using in situ tissue engineering approach

Shirakata Yoshinori, Richard Miron

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kagoshima University

2016/04/01 - 2019/03/31

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Periodontitis is a globally prevalent inflammatory disease that causes destruction of periodontal tissues. In the past 4 decades, a variety of procedures, including bone grafting, guided tissue regeneration, and the use of growth factors (GFs) have been performed either alone or in combination to accomplish periodontal regeneration. More recently, tissue engineering technologies using scaffolds, GFs and cells have been reported for regenerative medicine. However, all current approaches have been shown to have variable outcomes and limitations. To obtain favorable periodontal healing, there is an ongoing need to develop more reasonable therapeutics based on self-repair capacity in injured periodontal defects where the progenitor/stem cells from neighboring tissues can be recruited for in situ periodontal regeneration. Thus, a novel periodontal regenerative therapy using rhBMP9, bone perforation, and low-intensity pulsed ultrasound that avoid cell transplantation was developed.
Development of new regeneration therapy using strong osteoplasty protein BMP-9 and cells derived from adipose tissue

NOGUCHI Kazuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Kagoshima University

2015/04/01 - 2018/03/31

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The purpose of this study was development of new regenerative therapy for lost bone tissues due to periodontal and oral disease by using FK506 together with BMP-9 for signal molecules and stem cells (ADSC) and dedifferentiated fat cells(DFAT) which derived from adipose tissue as a source of cell transplant. In vitro study demonstrated that BMP-9 and FK506 costimulation induces promotion of osteoblasts-like differentiation in both rat ADSC and rat DFAT. Furthermore , we demonstrated that rDFAT cells culture supernatant of BMP-9 and FK506 costimulation have bone regenerative potential in rat calvarial defects model.
A basic research on dental implants with periodontal tissue based on induction of cementblast differentiation

SAKODA Kenji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kagoshima University

2015/04/01 - 2018/03/31

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We found that CEMP-1 expression was enhanced by stimulating mesenchymal stem cells with enamel matrix protein (EMD). The expression of CEMP-1 involves the transcription factor HIF-1. We found that stimulation of periodontal ligament fibroblasts (HPDLF) with EMD raises HIF-1 transcriptional activity. One target molecule of HIF-1 is SDF-1. Since SDF-1 induces mesenchymal stem cells, we investigated its production. We found that SDF-1 production increased when HPDLF were stimulated with EMD. Therefore, SDF-1 may promote periodontal regeneration by induction of mesenchymal stem cells. EMD and SDF-1 are expected to be applied to dental implant treatment.
Novel role of osteocytes in periodontal disease Competitive

Sena Kotaro, MACHIGASHIRA Miho

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kagoshima University

2015/04/01 - 2018/03/31

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Recently, osteocytes have been reported to play an important role in bone metabolism which indicates osteocytes may play a role in periodontal disease. In this project, we determined the mechanism how lipopolysaccharide isolated from Porphyromonas gingivalis（Pg-LPS）induced cytokine production by osteocytes. We further performed global analyses for Pg-LPS induced gene expression. Current findings suggest involvement of osteocytes in advanced periodontal disease with alveolar bone resorption by inducing cytokine production in response to periodontal pathogen.
Establishment of alveolar ridge augmentation induced by periodontal ligament using biomechanics

TAKEUCHI NAOSHI, SHIRAKATA Yoshinori, SHINOHARA Yukiya, SENA Kotaro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Kagoshima University

2015/04/01 - 2017/03/31

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For establishment of alveolar ridge augmentation using orthodontics, closed corticotomy that was a method to move teeth effectively was tested. In results, it was able to confirm a constant effect because teeth could be moved 5mm for 14 weeks. However, it is necessary to use thicker wire and to put on net so that dogs does not bite breeding cage for preventing teeth from moving slantingly. Also, the combination of the implant anchor should have examined an anchor because teeth for the fixation caused anchorage loss. The study of alveolar ridge augmentation using orthodontics will be tested in consideration of the above-mentioned points.
歯周組織の発生及び再生におけるTGF-βスーパーファミリー遺伝子発現の検索 Competitive

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Media Coverage 1

気になる症状すっきり診断（１８３）口から支えるがん治療／副作用の口内炎を予防 Myself

河北新報

2024/12/27

Type: Newspaper, magazine

Academic Activities 1

Review Editor

2022/06 - Present

Activity type: Peer review