Details of the Researcher

PHOTO

Tomoki Asaba
Section
Graduate School of Medicine
Job title
Specially Appointed Research Fellow
e-Rad No.
91035584

Research History 4

  • 2026/01 - Present
    Tohoku University　Graduate School of Medicine　Specially Appointed Researcher

  • 2025/10 - 2025/12
    Yokohama National University　Institute of Advanced Sciences　Visiting Associate Professor

  • 2023/04 - 2025/03
    Japan Society for the Promotion of Science　Grant-in-Aid for JSPS Research Fellows

  • 2022/04 - 2023/03
    Yokohama National University　Graduate school of Engineering Science　Special Researcher

Education 3

  • Yokohama National University　Graduate school of Engineering Science　Department of Chemistry, Chemical Engineering and Life Science

    - 2025

  • Yokohama National University　Graduate school of Engineering Science　Department of Chemistry, Chemical Engineering and Life Science

    - 2022

  • Yokohama National University　College of Engineering Science　Department of Chemistry, Chemical Engineering and Life Science

    - 2020

Committee Memberships 1

  • 化学とマイクロ・ナノシステム学会　化学とマイクロ・ナノシステム学会第50回研究会(CHEMINAS 50) 若手企画実行委員

    2024/11 -

Research Interests 2

  • アルツハイマー病における記憶障害の脳メカニズム

  • 記憶を支える脳回路メカニズム

Research Areas 3

  • Life sciences / Clinical pharmacy /

  • Life sciences / Physiology /

  • Life sciences / Neuroscience - general /

Awards 16

  1. 長期海外研究助成

    2026/02　東洋紡バイオテクノロジー研究財団

  2. 若手優秀賞

    2024/09　細胞再生医療研究会

  3. 研究奨励金特別手当

    2024　日本学術振興会

  4. 第61回日本人工臓器学会大会 萌芽研究ポスター優秀賞

    2023/11　一般社団法人 日本人工臓器学会

  5. 化学とマイクロ・ナノシステム学会第48回研究会 チップ・デバイスアートコンテスト-異種格闘技戦-優秀賞

    2023/11　化学とマイクロ・ナノシステム学会

  6. 化学とマイクロ・ナノシステム学会第48回研究会 チップ・デバイスアートコンテスト-異種格闘技戦- AI賞

    2023/11　化学とマイクロ・ナノシステム学会

  7. 第40回「センサ・マイクロマシンと応用システム」シンポジウム フォトコンテスト ミリ部門 優秀賞

    2023/11　電気学会 センサ・マイクロマシン部門

  8. ISBF Best Poster Presentation

    2023/09　International Society for Biofabrication

  9. 第54回化学工学会秋季大会 バイオ部会優秀ポスター賞

    2023/09　公益社団法人 化学工学会

  10. 第31回生物工学論文賞

    2023/09　生物工学会

  11. 化学応用・バイオユニットポートフォリオ発表会 グッドプレゼンテーション賞

    2022/03　横浜国立大学大学院理工学府

  12. 第21回日本再生医療学会総会 組織工学とその基盤技術2 最も内容の良かった演題

    2022/03　日本再生医療学会

  13. 第10回日本生物工学会東日本支部コロキウム 東日本支部学生奨励賞

    2022/03　日本生物工学会

  14. 理工系創立100周年記念事業 YNU理工系合同研究シンポジウム 優秀講演賞

    2022/03　横浜国立大学

  15. 1st Prizes Poster Awards

    2021/11　MRS-T International Conference

  16. 第34回日本動物細胞工学会 若手口頭発表部門 優秀発表賞

    2021/07　日本動物細胞工学会

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Papers 7

  1. In vitro and in vivo models for androgenetic alopecia drug development Peer-reviewed

    Shan Tu, Ayaka Nanmo, Yuki Migita, Tomoki Asaba, Jieun Seo, Sayuri Hamano, Tatsuto Kageyama, Junji Fukuda

    Disease Models & Mechanisms　19　(6)　2026/06/01

    Publisher: The Company of Biologists

    DOI： 10.1242/dmm.052848 　

    ISSN： 1754-8403

    eISSN： 1754-8411

    More details Close

    ABSTRACT Alopecia is a common disorder that can cause hair loss owing to various factors, including genetics, stress and diet. Androgenetic alopecia (AGA), also known as male pattern baldness, is the most common type of progressive hair loss. AGA symptoms can be alleviated by effective drugs, such as finasteride and minoxidil. Therefore, most patients with alopecia select drug therapy as the first-line treatment. However, their side effects and variable efficacy have increased the demand for alternative treatment options for these patients. Despite the high clinical demand, the development of novel therapeutic agents remains limited, primarily due to the lack of physiologically relevant drug testing models that accurately predict drug effects in humans. In this At a Glance article, we provide an overview of the currently available in vitro models for hair drug testing. First, we outline the limitations of traditional models, such as two-dimensional cultures and animal models, in reproducing hair follicle structures and multicellular signaling pathways. We then introduce three-dimensional culture platforms that partially overcome these drawbacks. Next, we discuss the differences and applications of various models in terms of functional readouts, reproducibility, high-throughput potential, standardization and cost. We highlight recent progress in the development of follicular skin model constructs and propose practical metrics for selecting the most appropriate model for the initial screening of potential hair drugs. Overall, this At a Glance article provides a roadmap towards a more translationally valuable screening system for the discovery and development of hair loss treatments.

  2. Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine. International-journal Peer-reviewed

    Tatsuto Kageyama, Riki Anakama, Sayuri Hamano, Shan Tu, Yuki Migita, Tomoki Asaba, Ayaka Nanmo, Kouyou Ishikawa, Lei Yan, Jieun Seo, Junji Fukuda

    ACS biomaterials science & engineering　2026/02/09

    DOI： 10.1021/acsbiomaterials.5c01780 　

    More details Close

    Organoids containing hair follicles can be regenerated in vitro using human induced pluripotent stem cells (hiPSCs) and potentially used as a tissue graft for hair regeneration. There are two main approaches to organoid formation: one is to form embryoid bodies from hiPSCs and induce differentiation into several organs and tissues, and the other is to induce tissue precursor epithelial and mesenchymal cells from hiPSCs and coculture them to generate organs and tissues via epithelial-mesenchymal interaction. Our ultimate aim is to differentiate hiPSCs into hair follicle epithelial and mesenchymal stem cells, and to subsequently purify and use them to generate hair follicle organoids (HFOs). We previously showed that murine embryonic skin-derived stem cells could be used to generate mouse HFOs with ∼100% efficiency. However, the key to inducing mouse HFOs is the supplementation of Matrigel at very low concentrations, and this mouse tumor-derived matrix cannot be applied in human treatment. In the current study, we found that collagen I provided a microenvironment for inducing HFOs that was equivalent to that induced by Matrigel. Furthermore, hiPSCs were differentiated into human ectodermal precursor cells and subsequently used to generate human/mouse chimeric HFOs with mouse embryonic mesenchymal cells. The human/mouse chimeric HFOs showed hair follicle sprouting both in vitro and in vivo. Although another approach to induce human mesenchymal layer cells from hiPSCs is necessary to generate fully human HFOs, this study demonstrates the potential of employing hiPSC-derived ectodermal precursor cells (hiPSC-EPCs) in HFO cultures in hair regenerative medicine.

  3. Human iPSC-derived cerebral organoids reveal oxytocin-mediated protection against amyloid-β pathology Peer-reviewed

    Tomoki Asaba, Sayuri Hamano, Ayaka Nanmo, Jieun Seo, Tatsuto Kageyama, Junji Fukuda

    Regenerative Therapy　30　259-267　2025/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.reth.2025.06.013 　

    ISSN： 2352-3204

  4. Effects of vascular endothelial cells on the neurite outgrowth of nerve cells Peer-reviewed

    Tomoki Asaba, Tatsuya Osaki, Koki Murayama, Sayuri Hamano, Tatsuto Kageyama, Junji Fukuda

    Journal of Bioscience and Bioengineering　140　(3)　168-173　2025/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.jbiosc.2025.05.010 　

    ISSN： 1389-1723

  5. Fabrication of neurovascular organoids in microdevices Peer-reviewed

    Tomoki Asaba, Junji Fukuda

    Tissue Engineering Part A　30　177-177　2024/02

  6. Bioprinting of hair follicle germs for hair regenerative medicine Peer-reviewed

    Ayaka Nanmo, Lei Yan, Tomoki Asaba, Licheng Wan, Tatsuto Kageyama, Junji Fukuda

    Acta Biomaterialia　165　50-59　2023/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.actbio.2022.06.021 　

    ISSN： 1742-7061

  7. Effects of the PI3K/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads Peer-reviewed

    Monami Yamane, Jieun Seo, Yinghui Zhou, Tomoki Asaba, Shan Tu, Ayaka Nanmo, Tatsuto Kageyama, Junji Fukuda

    Journal of Bioscience and Bioengineering　134　(1)　55-61　2022/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.jbiosc.2022.03.010 　

    ISSN： 1389-1723

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Misc. 9

  1. Effects of the PI3K/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads Peer-reviewed

    Seibutsu-kogaku Kaishi　102　(2)　65-65　2024/02/25

    Publisher: The Society for Biotechnology, Japan

    DOI： 10.34565/seibutsukogaku.102.2_65 　

    ISSN： 0919-3758

    eISSN： 2435-8630

  2. 第61回日本人工臓器学会大会 萌芽研究ポスター発表優秀賞 受賞レポート

    浅場智貴, 福田淳二

    人工臓器　53　(1)　47　2024

  3. 神経血管相互作用を利用した大脳オルガノイド構築のためのマイクロデバイス

    浅場智貴, 福田淳二

    化学工学会バイオ部会 Newsletter　58　30　2023/12

  4. Fabrication of Neurovascular Organoids in Microdevices

    浅場智貴, 福田淳二

    センサ・マイクロマシンと応用システムシンポジウム(CD-ROM)　40th　2023

  5. 神経血管相互作用を利用した大脳オルガノイド構築法

    浅場智貴, 福田淳二

    人工臓器(日本人工臓器学会)　52　(2)　2023

    ISSN： 0300-0818

  6. 神経血管相互作用を利用した大脳オルガノイド構築のためのマイクロデバイス

    浅場智貴, 福田淳二

    化学工学会秋季大会研究発表講演要旨集(CD-ROM)　54th　2023

  7. 神経血管相互作用を利用した次世代神経オルガノイド構築法の確立

    浅場智貴, 福田淳二

    日本再生医療学会総会(Web)　21st　2022

  8. 神経・血管相互作用を利用した神経オルガノイドの構築

    浅場智貴, 福田淳二

    化学とマイクロ・ナノシステム学会研究会講演要旨集(CD-ROM)　45th　2022

  9. 血管新生と軸索構造を備えた次世代神経オルガノイド構築法の確立

    浅場智貴, 福田淳二

    Program & Abstracts. Annual and International Meeting of the Japanese Association for Animal Cell Technology　34th　2021

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Research Projects 1

  1. Fabrication of Neurovascular Organoids in Microdevices

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for JSPS Fellows

    Institution: Yokohama National University

    2023/04/25 - 2025/03/31