TOHOKU UNIVERSITY Researchers - Toru Nakazawa

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Toru Nakazawa

Section

Graduate School of Medicine

Job title

Professor

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/read0163727

J-GLOBAL ID

200901037541266290

Research History 10

2023/04 - Present

Tohoku University
2018/10 - Present

東北大学病院　臨床試験推進センター　副センター長
2011/09 - Present

Tohoku University Graduate School of Medicine　Professor,
2018/04 - 2019/03

Nagasaki University　School of Medicine
2016/04 - 2019/03

国立大学法人理科学研究所光量子工学研究領域エクストリームフォトニクス研究グループ画像情報処理研究チーム客員研究員
2009/04 - 2011/08

Associate Professor, Tohoku University Graduate School of Medicine
2007/04 - 2009/03

Assistant Professor, Tohoku University Graduate School of Medicine
2006/04 - 2007/03

東北大学医学部附属病院　助手
2003/04 - 2006/03

Research Fellow, Mass Eye and Ear Infirmary, Harvard Medical School　Research Fellow
2002/04 - 2003/04

公立刈田病院　眼科　眼科長

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Education 2

東北大学大学院　医学系研究科外科学専攻眼科学分野卒業

1998/04 - 2002/03
Tohoku University　Faculty of Medicine

1989/04 - 1995/03

Committee Memberships 62

JJO　編集委員

2023/04 - Present
日本眼科学会雑誌　編集委員長

2023/04 - Present
日本眼科学会　常務理事

2023/04 - Present
東北大学大学院医学系研究科附属創生応用医学研究センター　医用知能ロボティクスコアセンター長

2021/11 - Present
未来社会健康デザイン拠点　未来社会健康デザインプロジェクト未来ビジョン策定委員会委員

2021/04 - Present
ROHTO AWARD 選考委員

2019/06 - Present
Neuro Global 国際共同大学院プログラム参画教員

2019/04 - Present
仙台赤十字病院臨床研修管理委員会委員

2019/04 - Present
東北大学未来型医療創造卓越大学院プログラム未来型医療教育研究センター運営委員会連携企画担当

2019/04 - Present
東北大学総長特別補佐

2019/04 - Present
東北大学大学院医学系研究科　研究科長特別補佐

2019/04 - Present
東北大学病院臨床研究推進センター副センター長

2018/10 - Present
東北大学高等研究機構未来型医療創成センター副センター長

2018/06 - Present
公益財団法人アステラス病態代謝研究会学術委員

2018/06 - Present
仙台オープン病院研修管理委員会委員

2018/04 - Present
公立相馬総合病院臨床研修管理委員会委員

2017/10 - Present
東北大学医師会監事

2017/05 - Present
東北大学医学系研究科メガバンク連携室長

2017/04 - Present
東北大学病院卒後研修センター長

2017/04 - Present
東北メディカル・メガバンク機構運営委員会委員

2017/03 - Present
Glaucoma Research Society Active Member

2016/10 - Present
東北文化学園大学　客員教授

2016/04 - Present
Journal for Modeling in Ophthalmology Editorial Board

2016 - Present
Journal for Modeling in Ophthalmology　編集委員

2016/01 - Present
日本眼循環学会理事

2015/06 - Present
日本緑内障学会理事

2014/04 - Present
国立大学法人理化学研究所光量子工学研究領域エクストリームフォトニクス研究グループ画像情報処理研究チーム客員研究員

2014/04 - Present
東北屈折矯正研究会　顧問

2014/01 - Present
独立行政法人医薬品医療機器総合機構専門委員

2013/08 - Present
東北大学病院　病院長特別補佐

2013/04 - Present
公益財団法人東北大学アイバンク代表理事

2012/04 - Present
Japanese Ophthalmological Society　編集委員

2012/04 - Present
Japanese Journal of Ophthalmology Section Editor (Glaucoma)

2012 - Present
日本緑内障学会評議員

2010/04 - Present
東北医科薬科大学病院臨床研修管理委員会委員

- Present
みやぎ県南中核病院臨床研修員会委員

- Present
石巻赤十字病院臨床研修管理委員会委員

- Present
公益財団法人一迫記念READ血液アカデミー顧問〔C：東北大学及び血液学OB・OG関係〕

- Present
日本眼科啓発委員

- Present
東北大学未来型医療創成センター中核メンバー（運営・企画委員会委員）

2017/03 - 2018/06
公益財団法人アステラス病態代謝研究会学術委員

2014/04 - 2018/06
日本眼科学会雑誌編集委員

2012 - 2017/08
日本眼科学会戦略企画会議第4委員会「研究と人材育成」委員

2015/07 - 2017/06
日本眼科学会　日本眼科学会戦略企画会議第4委員会「研究と人材育成」委員

2015/07 - 2017/06
公益財団法人アステラス病態代謝研究会　学術委員

2015/07 - 2017/06
公益財団法人アステラス病態代謝研究会　選考委員

2015/07 - 2017/06
日本眼科学会　日本眼科学会専門医制度委員会生涯教育委員会委員

2015/06 - 2017/06
Asia-Pacific Journal of Ophthalmology Editorial Board Section Editor　Section Editor (Visual Sciences)

2011/01 - 2016/12
日本眼科学会　第16期日本眼科学会専門医制度委員生涯教育委員

2013/06 - 2016/06
基本領域（眼科）専門医委員会委員

2014/05 - 2016/05
一般社団法人日本医療安全調整機構日本専門医機構　一般社団法人日本専門医機構の基本領域(眼科)専門医委員会委員

2014/05 - 2016/05
Asia-Pacific Journal of Ophthalmology Editorial Board Section Editor (Visual Sciences)

2011 - 2016
日本眼科学会　生涯教育委員

2013/06 - 2015/06
日本緑内障学会　理事

2014/04 - 2015/03
日本医療メディエーター協会東北支部理事

2013/04 - 2015/03
科学研究費委員会　専門委員

2013/12 - 2014/11
日本眼科学会　東北ブロック地域推薦窓口担当者

2013/06 - 2014/05
日本学術振興会　科学研究費委員会専門委員

2013/12 - 2014/04
日本眼科学会　Japanese-Journal of Ophthalmologyセクションエディター

2012/01 - 2013/04
東北大学アイバンク　理事

2006/12 - 2007/03
一般社団法人日本医療安全調整機構　日本眼科学会東北ブロック地域評価委員

2014/05 -
日本眼薬理学会　評議員

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Professional Memberships 8

Japanese Neuro-Ophhtalmology Society
日本緑内障学会
The Association for Research in Vision and Ophtalmology(2012/05-2012/05)
公益財団法人一迫記念READ血液アカデミー(2011/10- 顧問)
財団法人日本眼科学会
Japanese society of Cantaract and Refracitive Surgery(2012/01-2012/12)
日本眼科医連盟
Ophthalmologic Society of Anti-Aging Medicine(2011/11- )

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Research Interests 5

神経保護治療
機械学習
画像
エンドポイント設定
創薬

Research Areas 1

Life sciences / Ophthalmology /

Awards 13

Best Doctors in Japan2022-2023

2022
Best Doctors in Japan2020-2021

2020
Best Doctors in Japan

2018　Best Doctors in Japan
評議員会賞

2014　日本眼科学会
平成26年日本医師会医学研究奨励賞

2014
医学系研究奨励金

2009　武田科学財団
Glaucoma Summer Camp. Young Investigator Award

2009
日本眼科学会学術奨励賞

2009
今井記念緑内障研究助成基金

2008
ROHTO AWARD

2008
Uehara Research Foundation

2008
須田賞（須田記念緑内障治療研究奨励基金）

2006
bausch＆Lomb Vitreoretinal Fellowship

2003

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Papers 547

Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism. International-journal

Akiko Ogawa, Satoshi Watanabe, Iuliia Ozerova, Allen Yi-Lun Tsai, Yoshihiko Kuchitsu, Harrison Byron Chong, Tomoyoshi Kawakami, Jirio Fuse, Wei Han, Ryuhei Kudo, Tomoki Naito, Kota Sato, Toru Nakazawa, Yasunori Saheki, Akiyoshi Hirayama, Peter F Stadler, Mieko Arisawa, Kimi Araki, Liron Bar-Peled, Tomohiko Taguchi, Shinichiro Sawa, Kenji Inaba, Fan-Yan Wei

Cell　2025/08/13

DOI： 10.1016/j.cell.2025.07.041 　

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RNA contains diverse post-transcriptional modifications, and its catabolic breakdown yields numerous modified nucleosides requiring correct processing, but the mechanisms remain unknown. Here, we demonstrate that three RNA-derived modified adenosines, N6-methyladenosine (m6A), N6,N6-dimethyladenosine (m6,6A), and N6-isopentenyladenosine (i6A), are sequentially metabolized into inosine monophosphate (IMP) to mitigate their intrinsic cytotoxicity. After phosphorylation by adenosine kinase (ADK), they undergo deamination by adenosine deaminase-like (ADAL). In Adal knockout mice, N6-modified adenosine monophosphates (AMPs) accumulate and allosterically inhibit AMP-activated protein kinase (AMPK), dysregulating glucose metabolism. Furthermore, ADK deficiency, linked to human inherited disorders of purine metabolism, elevates levels of the three modified adenosines, resulting in early lethality in mice. Mechanistically, excessive m6A, m6,6A, and i6A impair lysosomal function by interfering with lysosomal membrane proteins, thereby disrupting lipid metabolism and causing cellular toxicity. Through this nucleotide metabolism pathway and mechanism, cells detoxify modified adenosines, linking modified RNA metabolism to human disease.
AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal ganglion cell loss in rats. International-journal

Ge Shi, Kota Sato, Nana Takahashi, Michiko Ohno-Ohishi, Namie Murayama, Chiaki Yamaguchi, Daisuke Saigusa, Toru Nakazawa

Life science alliance　8　(8)　2025/08

DOI： 10.26508/lsa.202403087 　

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Dysfunction of ocular blood flow (BF) is believed to be one of the causes of glaucomatous pathology. However, whether this dysfunction is indeed a cause or is actually a consequence of optic nerve degeneration remains controversial. Here, we established a new animal model of chronic BF reduction in the retina to mimic glaucoma. We found that retinal BF in rats, as measured with laser speckle flowgraphy, was significantly reduced 3 wk after an intravitreal injection of AAV2-human endothelin-1 (AAV2-hEDN1). The number of retinal ganglion cells was also reduced in rats that received AAV2-hEDN1 injection. Immunostaining signals for GFAP and the endothelin-B receptor were enhanced in the rat retinas after AAV2-hEDN1 injection. Moreover, mRNA levels of Ripk1/Ripk3 and Tnf in the retina increased, and glutathione levels in the aqueous humor decreased in rats that received AAV2-hEDN1 injection. Our findings demonstrate that endothelin-induced chronic retinal BF reduction leads to increased astrocyte activation and oxidative stress, which in turn induces retinal ganglion cell necroptosis. This suggests that methods to improve ocular BF have potential as novel therapies for glaucoma.
The Relationship between MRI-Measured Structure of the Visual Cortex and Visual Function in Patients with Glaucoma. International-journal

Akio Yamada, Yasuko Tatewaki, Kazuko Omodaka, Izumi Matsudaira, Yasuyuki Taki, Toru Nakazawa

Journal of glaucoma　2025/07/30

DOI： 10.1097/IJG.0000000000002614 　

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PRCIS: The area corresponding to the peripheral visual field in the primary visual cortex of the brain is associated with ophthalmologic parameters. PURPOSE: Reproducing the relationship of the visual field with the primary visual cortex is known as retinotopic mapping. The primary visual cortex is known to be atrophic in glaucoma patients. However, there are few reports on which areas most reflect glaucomatous changes. In this study, we used magnetic resonance imaging to evaluate the relationship between various ophthalmic parameters and overall and regional structural changes in the primary visual cortex to better understand changes in the brain associated with glaucoma. MATERIALS AND METHODS: Twelve healthy subjects (56.1±9.3 years old, male to female ratio 6:6, mean deviation [MD] 0.6±0.7 dB) and 23 patients with glaucoma (57.8±8.0 years old, male to female ratio 8:15, MD -10.2±6.4 dB) were enrolled. We acquired 3D-T1-weighed images to measure the overall and regional gray matter density of the visual cortex based on a priori retinotopic projection. Optical coherence tomography and visual field testing were performed, and a weighted count of retinal ganglion cells (wRGC) was calculated from the ophthalmological tests. The Spearman rank correlation coefficient was used for evaluating the correlations between these structural parameters of the visual cortex and the ophthalmological parameters. RESULTS: The overall primary visual cortex was positively correlated with MD (r=0.40, P=0.02) and wRGC (r=0.41, P=0.02). Regarding retinotopic projection, the inner area in the visual cortex, which corresponds to the peripheral visual field, was positively correlated with MD and wRGC. CONCLUSION: The inner part of the primary visual cortex, which corresponds to the peripheral visual field, is closely correlated with ophthalmologic parameters commonly used for diagnosing and detecting the progression of glaucoma clinically. This suggests that evaluation of this area with MRI may be of clinical use in glaucoma assessment and monitoring.
Role of HAUS7 as a DOCK3 binding partner in facilitating axon regeneration. International-journal

Naoki Kiyota, Youichi Shinozaki, Xiaoli Guo, Atsuko Kimura, Kazuto Kawamura, Euido Nishijima, Sari Honda, Chikako Harada, Toru Nakazawa, Kazuhiko Namekata, Takayuki Harada

Science advances　11　(30)　eadq7105　2025/07/25

DOI： 10.1126/sciadv.adq7105 　

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The molecular mechanisms involved in reconstructing the eye-to-brain connection and functional recovery following optic nerve damage remain unclear. This study revealed that HAUS augmin-like complex subunit 7 (HAUS7) is a molecule that binds to dedicator of cytokinesis 3 (DOCK3), a regulator of neurotrophic factor signaling and axon regeneration. We observed a distribution pattern of HAUS7 expression, suggesting that neuronal HAUS7 is transported from the cell body to the growth cone under the control of DOCK3. In addition, phosphorylation of DOCK3 at Y562 by tropomyosin receptor kinase B signaling leads to the dissociation of HAUS7, which is considered an important step for microtubule assembly. Deletion of Haus7 in mice significantly reduced microtubule formation and axon regeneration following optic nerve crush (ONC). Transcriptome analysis suggested that HAUS7 levels decrease in glaucoma and after the ONC, while retinal ganglion cells actively regenerating their axons express high levels of HAUS7. In summary, HAUS7 is a binding partner of DOCK3 necessary for axon elongation.
Reduced plasma oxytocin levels in patients with open-angle glaucoma.

Yurina Yamada, Kota Sato, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Naoki Kiyota, Naoki Takahashi, Yoko Takeda, Chiaki Yamaguchi, Kazuko Omodaka, Toru Nakazawa

Japanese journal of ophthalmology　2025/07/14

DOI： 10.1007/s10384-025-01248-6 　

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PURPOSE: We explored the role of oxytocin in glaucoma by measuring the blood levels of oxytocin in glaucoma patients, comparing them to normal control subjects, and examining its association with clinical parameters. STUDY DESIGN: Retrospective cross-sectional study. MATERIAL AND METHODS: After obtaining informed consent from 181 glaucoma patients and 44 age-matched control participants, we collected blood samples in ethylenediaminetetraacetic acid (EDTA) tubes and centrifuged them at 2000 g for 25 minutes at 4 °C. The resulting plasma was assayed for oxytocin concentration with an Enzyme Linked Immunosorbent Assay (ELISA) kit. We compared oxytocin concentrations in the control and glaucoma groups, and within the glaucoma group, we determined whether the oxytocin levels were correlated with mean deviation (MD) and sectoral total deviation (TD). Furthermore, in 33 patients who underwent at least five visual field tests over a two-year period following oxytocin measurements and received no surgical interventions during that time, we determined whether the oxytocin levels were correlated with MD slope and sectoral TD slopes. RESULTS: Oxytocin levels in glaucoma patients were significantly lower than in age- and sex-matched normal controls (723.34 ± 303.44 vs. 557.59 ± 296.04 pg/ml, p=0.002). In glaucoma patients, oxytocin levels were significantly correlated with MD and inferior TD after adjustment for age and sex (β=0.149, p=0.041; β=0.156, p=0.034, respectively). There was a weak negative correlation between oxytocin concentration and MD slope (β=-0.334, p=0.084) and a weak negative correlation with central TD slope (β=-0.405, p=0.039), adjusted for age, sex, and history of additional eye drops. CONCLUSION: Oxytocin concentrations in glaucoma patients were significantly lower than in normal subjects and associated with the severity and progression of visual field defects. Given the wide variety of the pharmacological actions of oxytocin, it may be involved in the pathogenesis of glaucoma. Our results suggest that plasma oxytocin measurements may open a new avenue for glaucoma care.
Electroretinogram as an Early Diagnostic Biomarker for Acute Retinal Necrosis: A Multicenter Comparative Study. International-journal

Shunichi Fukuyama, Kazuichi Maruyama, Masaaki Yoshida, Hiroaki Ushida, Kazuki Hashimoto, Satoko Fujimoto, Takuya Shunto, Nobuhiko Shiraki, Toru Nakazawa, Martine J Jager, Koji M Nishiguchi, Kohji Nishida

Ocular immunology and inflammation　1-10　2025/07/13

DOI： 10.1080/09273948.2025.2532049 　

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PURPOSE: Acute retinal necrosis (ARN) is a rare but severe ocular condition that often results in significant visual impairment or blindness. We aimed to determine whether ARN exhibits a distinct electroretinogram (ERG) waveform compared with other infectious and non-infectious uveitis forms. METHODS: This retrospective observational multicenter study included a total of 73 patients; 21 with ARN, 9 with bacterial endophthalmitis, 16 with other types of infectious uveitis, and 27 with non-infectious uveitis. Full-field electroretinography was performed at the initial examination to evaluate retinal function. Additionally, initial and post-treatment visual acuity were recorded. The a- and b-wave amplitudes were measured and compared between the groups. RESULTS: Patients with ARN had significantly reduced a- and b-wave amplitudes than the other types of infectious and non-infectious uveitis at the first visit (p < 0.01). Receiver operating characteristic analysis showed that an a-wave amplitude reduction of more than 73% discriminated ARN from other infectious uveitis with 75% sensitivity and 90% specificity (area under the curve [AUC] = 0.84), while a reduction greater than 49% discriminated ARN from non-infectious uveitis with 89% sensitivity and 76% specificity (AUC = 0.83). Pre-treatment visual acuity was the strongest predictor of visual prognosis. CONCLUSIONS: ERG response is significantly reduced in the early stages of ARN. Therefore, ERG may serve as a valuable diagnostic tool for ARN, particularly when specialist examination or definitive diagnosis based on clinical findings is delayed. Given that early treatment improves the prognosis of ARN, this finding highlights the critical role of early diagnosis in preventing vision loss.
Involvement of Microglia in Retinal Ganglion Cell Injury Induced by IOP Elevation in a Rat Ex Vivo Acute Glaucoma Model. International-journal

Taimu Sato, Makoto Ishikawa, Yukitoshi Izumi, Naoya Shibata, Kota Sato, Michiko Ohno-Oishi, Hiroshi Tawarayama, Hiroshi Kunikata, Charles F Zorumski, Toru Nakazawa

Biomedicines　13　(7)　2025/07/08

DOI： 10.3390/biomedicines13071670 　

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Background: An acute angle-closure attack (AAC) is an ocular emergency that results from a rapid increase in intraocular pressure (IOP). Sustained IOP elevation induces severe degeneration of retinal ganglion cells (RGCs) without treatment. Overactivated microglia, key participants in innate immune responses, have critical roles in the pathogenesis of IOP-induced RGC death, although precise mechanisms remain unclear. In the present study, we used a rat ex vivo acute glaucoma model to investigate the role of microglial signaling in RGC death and examined whether pharmacological depletion of microglia using a CSF-1R inhibitor, PLX5622, exerts neuroprotection against pressure-induced retinal injury. Methods: Ex vivo rat retinas were exposed to hydrostatic pressure (10 mmHg or 75 mmHg) for 24 h. Pressure-dependent changes in retinal microglia and RGCs were detected by immunofluorescence. Morphological changes in the retina and RGC apoptosis were examined using light microscopy and TUNEL staining, respectively. The expression of NLRP3, active caspase-1, pro IL-1β, and IL-1β were examined using Western blotting. Effects of PLX5622, an agent that depletes microglia, were examined in morphology, apoptosis, and protein expression assays, while TAK-242, a TLR4 inhibitor, was examined against protein expression. Results: Pressure loading at 75 mmHg markedly increased activated microglia and apoptotic RGCs in the isolated retinas. Western blotting revealed increases in expression of NLRP3, active caspase-1, pro IL-1β, and IL-1β at 75 mmHg compared to 10 mmHg. Inhibition of pressure-induced increases in NLRP3 by TAK-242 indicates that pressure elevation induces RGC death via activation of the TLR4-NLRP3 inflammasome cascade. PLX5622 depleted microglia at 75 mmHg and significantly decreased expression of NLRP3, active caspase-1, pro IL-1β, and IL-1β at 75 mmHg, resulting in preservation of RGCs. Conclusions: These results indicate that pressure elevation induces proliferation of inflammatory microglia and promotes IL-1β production via activation of the TLR4-NLRP3 inflammasome cascade, resulting in RGC death. Pharmacological depletion of microglia with PLX5622 could be a potential neuroprotective approach to preserve RGCs from inflammatory cytokines in AAC eyes.
Effect of Deep Optic Nerve Head Morphology on Lamina Cribrosa and Peripapillary Scleral Configurations in Healthy Eyes. International-journal

Nobuko Enomoto, Hitomi Saito, Makoto Araie, Mitsuki Kambayashi, Hiroshi Murata, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Aiko Iwase, Goji Tomita, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M Zangwill, Robert N Weinreb

Investigative ophthalmology & visual science　66　(9)　66-66　2025/07/01

DOI： 10.1167/iovs.66.9.66 　

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PURPOSE: The purpose of this study was to investigate the relationship among deep optic nerve head (ONH), lamina cribrosa (LC), and peripapillary sclera (pSc) configurations in healthy eyes. METHODS: This prospective cross-sectional study included 205 healthy eyes of 141 subjects. Multivariable linear mixed models identified factors associated with LC curvature index, prelaminar thickness (PLT), pSc angle, and LC depth (LCD). Explanatory variables included age, gender, intraocular pressure, axial length (AXL), visual field sensitivity, disc area, disc ovality, disc torsion, Bruch's membrane opening (BMO)-minimum rim width (MRW), BMO and anterior scleral canal opening (ASCO) area, peripapillary zone area with and without Bruch's membrane (PPZ+BM/-BM), and peripapillary choroidal thickness (pChT). A sub-analysis was conducted by dividing the eyes at the median AXL. RESULTS: LC curvature was flatter in eyes with large PPZ-BM, long AXL, and shallow LCD (P = 0.002, P = 0.015, and P = 0.042, respectively). Similar factors exhibited consistent effects in longer AXL eyes, whereas different factors, BMO-MRW, ASCO-area, and pSc-angle, were associated in shorter AXL eyes (P = 0.006, P = 0.012, and P = 0.018. respectively). PLT was thinner in eyes with thin BMO-MRW, large ASCO area, and young age (P < 0.001, P < 0.001, and P = 0.009, respectively). The pSc angle was steeper in eyes with long AXL and large PPZ+BM (P < 0.001). LCD was deeper in eyes with thick pChT, thin BMO-MRW, and small ASCO area (P < 0.001, P < 0.001, and P = 0.004, respectively). CONCLUSIONS: Novel associations between LC configurations with scleral canal size, PPZ+BM/-BM, and BMO-MRW were found after correction for confounding deep ONH morphologies. Given that these structures are associated with glaucomatous changes, these inter-structure correlations should be considered when distinguishing LC changes between healthy and glaucomatous eyes.
ENO1 Dysfunction-Mediated Glycolytic Attenuation Exacerbates Oxidative Stress-Induced Retinal Ganglion Cell Death via Altered ATP Synthesis Pathway. International-journal

Naoki Takahashi, Hiroshi Tawarayama, Yuri Chida, Minami Takeda, Risa Shiokawa, Kota Sato, Satoru Tsuda, Toru Nakazawa

Investigative ophthalmology & visual science　66　(9)　63-63　2025/07/01

DOI： 10.1167/iovs.66.9.63 　

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PURPOSE: The effects of enolase dysfunction-mediated glycolytic attenuation on oxidative stress-induced retinal ganglion cell (RGC) death were investigated. METHODS: Retinal expression of Enolase (ENO) 1 and 2 was detected using immunohistochemistry. Exogenous genes were introduced into mouse RGCs using viral vectors, and into the rat-derived retinal progenitor cell line R28 using lipofection. The effects of enolase dysfunction were evaluated using N-methyl-D-aspartate (NMDA)-induced RGC death and H2O2-induced death assays. Cell viability and gene expression were investigated using the alamarBlue, quantitative RT-PCR, and Western blotting, respectively. Reactive oxygen species (ROS) were detected using CM-H2DCFDA dye. 2-deoxyglucose and oligomycin were used to attenuate adenosine triphosphate (ATP) production in glycolysis and oxidative phosphorylation (OXPHOS), respectively. RESULTS: ENO1 and ENO2 were expressed in the RGCs. Enolase overexpression inhibited NMDA-induced mouse RGC death, whereas deficiency of ENO1 but not ENO2 enhanced cell death. Additionally, ENO1 overexpression prevented the CDKN2B-induced enhancement of RGC death. H2O2 treatment increased ENO1 expression in R28 cells and inhibited H2O2-induced cell death. ATP production was immediately enhanced in ENO1 wild-type cells treated with H2O2. 2-deoxyglucose and oligomycin prevented enhanced ATP production, but ATP levels were still higher than, or similar to, those in untreated wild-type cells; in contrast, in knockdown cells, oligomycin-mediated OXPHOS inhibition led to lower ATP production in H2O2-treatment than in untreated cells. H2O2 treatment increased ROS production in knockdown R28 cells. CONCLUSIONS: ENO1 dysfunction leads to glycolytic attenuation, resulting in an excessive dependence of ATP production on OXPHOS under oxidative stress, contributing to excitotoxicity-induced RGC death. Preventing glycolytic attenuation may represent a promising treatment for RGC degeneration.
Detection of Cataract with a New Perimetry Method Using Retinal Projection Technology.

Takeshi Yabana, Naoko Takada, Satoru Tsuda, Makoto Ishikawa, Mai Yamazaki, Masataka Sato, Takahiro Ninomiya, Yu Yokoyama, Noriko Himori, Kazuki Hashimoto, Aki Osanai, Seiji Morino, Makoto Suzuki, Mitsuru Sugawara, Hiroshi Kunikata, Toru Nakazawa

The Tohoku journal of experimental medicine　2025/06/05

DOI： 10.1620/tjem.2025.J066 　
Evaluation of blood flow in arteritic anterior ischemic optic neuropathy using laser speckle flowgraphy: A case series International-journal

Chiaki Yamaguchi, Naoki Kiyota, Noriko Himori, Takahiro Oshima, Takayuki Takeshita, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

American Journal of Ophthalmology Case Reports　38　102316-102316　2025/06

DOI： 10.1016/j.ajoc.2025.102316 　

ISSN： 2451-9936
Two-Year Outcome of Selective Laser Trabeculoplasty for Normal-Tension Glaucoma in Japan: First-Line or Second-Line Selective Laser Trabeculoplasty (FSS) Study. International-journal

Tomoko Naito, Koji Nitta, Takako Miki, Akiko Narita, Tairo Kimura, Yasushi Ikuno, Shiro Mizoue, Maki Katai, Yoshiaki Saito, Mami Nanno, Naoki Tojo, Naoto Tokuda, Shigeki Yamabayashi, Katsuyoshi Suzuki, Kimihito Konno, Hiroaki Ozaki, Toru Nakazawa, Tadashi Nakano, Kenji Nakamoto, Naoya Nezu, Shigeru Mori, Kazuyuki Hirooka, Itaru Kimura, Takeshi Sagara, Toyoaki Tsumura, Aika Tsutsui, Kae Sugihara, Takuji Matsuda, Yoshitaka Tasaka, Satoru Tsuda, Tomoyuki Watanabe, Naka Shiratori, Yutaro Tobita, Kaori Komatsu, Akiko Harano, Kazuhisa Sugiyama, Keiji Yoshikawa, Masaki Tanito

Journal of clinical medicine　14　(10)　2025/05/15

DOI： 10.3390/jcm14103459 　

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Objectives: The objective of this study is to investigate the two-year continuous efficacy, risk factors, and safety profile of selective laser trabeculoplasty (SLT) in Japanese individuals diagnosed with normal-tension glaucoma (NTG) who underwent SLT as either a first-line or second-line treatment. Methods: A retrospective chart review was conducted of patients with NTG who underwent SLT as either an initial or secondary therapy at 26 medical institutions in Japan between January 2020 and December 2021 with a 2-year follow-up. The primary endpoint was a reduction in the rate of intraocular pressure (IOP) over 2 years after SLT. To estimate the time-varying effect of IOP reduction, a linear mixed-effects model was employed. The secondary endpoints were numerical IOP reduction, treatment success rates shown by a Kaplan-Meier analysis, and complications. Success was defined as an outflow pressure improvement rate (ΔOP) ≥ 20% (definition A) or an IOP reduction rate ≥ 20% (definition B) without further treatment. A Cox proportional hazards regression analysis was used to identify the risk factors to successful SLT treatment. The study was registered with UMIN-CTR (ID: UMIN R000064045). Results: A total of 230 eyes from 230 individuals participated in this study, with 148 eyes receiving SLT as an initial (first-line) therapy and 82 eyes undergoing SLT as a secondary (second-line) intervention. In the first-line group, the mean IOP dropped from 16.7 ± 2.3 mmHg to 13.7 ± 2.4 mmHg at two years post-treatment, reflecting a 16.8% reduction. In the second-line group, the average IOP declined from 15.9 ± 2.5 mmHg to 13.2 ± 2.0 mmHg, marking a 14.4% decrease over the same period. The treatment success rate according to definition A (ΔOP ≥ 20%) was 73.7% at 2 years. Analysis using a linear mixed-effects model identified time (p < 0.001), age (p = 0.044), baseline IOP (p < 0.001), and central corneal thickness (CCT) (p < 0.001) as statistically significant contributors to IOP reduction following SLT. However, neither the Group (first-line vs. second-line) variable (p = 0.386) nor the Time × Group interaction (p = 0.298) reached statistical significance. A lower baseline IOP and a thicker CCT were confirmed as significant predictors of SLT treatment failure. Conclusions: Both initial and secondary SLT treatments for NTG proved to be effective and safe over a two-year period, although the extent of IOP reduction was smaller in cases with a lower baseline IOP. Our findings indicate that the IOP-lowering effect of SLT in NTG is influenced by pretreatment IOP levels, aligning with previous studies on primary open-angle glaucoma and ocular hypertension. However, in contrast to those earlier findings, our research identified pretreatment central corneal thickness as a statistically significant factor influencing SLT efficacy in NTG. These results support the role of SLT as a reliable and safe therapeutic option for managing NTG.
Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study

Mami Ishikuro, Nobuo Fuse, Taku Obara, Aoi Noda, Genki Shinoda, Masatsugu Orui, Akira Uruno, Sayaka Yoshida, Naoko Takada, Shunsuke Fujioka, Takayuki Nishimura, Akiko Hanyuda, Ryo Kawasaki, Toru Nakazawa, Shinichi Kuriyama

AJO International　2　(1)　2025/04/28

DOI： 10.1016/j.ajoint.2024.100088 　

eISSN： 2950-2535
Relationships between distance from the fovea to the disc and macular retinal layer thickness differ between normal and glaucomatous eyes. International-journal

Tomomi Higashide, Sachiko Udagawa, Makoto Araie, Hitomi Saito, Daisuke Takemoto, Kazuhisa Sugiyama, Goji Tomita, Atsuya Miki, Tsutomu Kikawa, Aiko Iwase, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M Zangwill, Robert N Weinreb

Scientific reports　15　(1)　11554-11554　2025/04/04

DOI： 10.1038/s41598-025-96741-w 　

ISSN： 2045-2322
Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1. International-journal

Toshiaki Abe, Reiko Daigaku, Xie Yuting, Yasukazu Daigaku, Nobuhiro Nagai, Hirokazu Kaji, Aya Katsuyama, Yuki Katsukura, Yasuko Izumida, Atsuko Suzuki, Shinji Yamada, Yao-Wen Chang, Keiko Terada, Sei-Ichi Ishiguro, Noriko Osumi, Hiroshi Kunikata, Toru Nakazawa

Investigative ophthalmology & visual science　66　(4)　70-70　2025/04/01

DOI： 10.1167/iovs.66.4.70 　

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PURPOSE: The retinal pigment epithelium (RPE) performs life-long phagocytosis of lipid-rich photoreceptor outer segments and exchanges energy metabolites with photoreceptors to support retinal function. The metabolites of glucose and lipid metabolism are interconnected, but it is unclear how the specialized lipid metabolism of RPE and glucose metabolism are regulated. We have investigated this unique mechanism. METHODS: To identify factors involved in regulation of metabolism in RPE we compared and screened the human retinal pigment epithelial cell line, ARPE-19 under different conditions. Using the results of these experiments we selected the high-mobility group nucleosome-associated protein 1 (HMGN1) as a candidate and analyzed HMGN1 deleted ARPE-19 (HGMN1-/--ARPE-19) and Hmgn1 knock-out mice (Hmgn1-/- mice). RESULTS: HMGN1 was identified as being involved in energy metabolism via altered expression. HMGN1-/--ARPE-19 cells prefer fatty acid oxidation over glucose metabolism as an energy source. Hmgn1-/- mice had a lower lipid weight of epididymal fat mass and serum lipids than those of control on a standard diet and showed impaired glucose tolerance. The mice also showed retinal dysfunction, similar to that observed in aged control retina as measured by electroretinogram. However, a palmitate-rich diet, as well as RPE-specific HMGN1 re-expression mitigated retinal dysfunction. HMGN1 is specifically downregulated in the RPE/choroid with aging, which is reminiscent of age-related metabolic changes in RPE/choroid. CONCLUSIONS: HMGN1 is involved in energy metabolism and its altered expression modulates RPE-specific metabolic phenotypes.
Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition. International-journal

Nana Takahashi, Yukihiro Shiga, Naoki Kiyota, Masayuki Yasuda, Naoki Takahashi, Kota Sato, Ryutaro Arita, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Toru Nakazawa

Translational vision science & technology　14　(4)　9-9　2025/04/01

DOI： 10.1167/tvst.14.4.9 　

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PURPOSE: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence of patients with primary open-angle glaucoma (POAG) with vascular predisposition. METHODS: The Flammer Syndrome Questionnaire (FSQ) was used to determine vascular risk scores in 823 healthy subjects and 512 patients with POAG. Next, we characterized blood flow pulsatility changes within the optic nerve head (ONH) in Flammer syndrome (FS) using laser speckle flowgraphy (LSFG) in 358 eyes of 206 patients with normal-tension glaucoma (NTG). Last, we examined the association between changes in Mean blur rate (MBRAve), an LSFG-derived ONH blood flow measurement, during cold provocation and the FSQ risk score in 56 eyes of 56 patients with NTG. RESULTS: Five FSQ-related symptoms were significantly associated in patients with POAG patients; cold hands/feet (odds ratio [OR] = 1.82), low blood pressure (BP; OR = 3.29), increased response to drugs (OR = 2.27), underweight (OR = 1.99), and tendency toward perfectionism (OR = 1.88). The vascular risk score showed the best discriminative accuracy in differentiating healthy subjects from patients with NTG (area under the curve [AUC] = 0.73). In the NTG eyes, ONH pulsatile blood flow in the FS group was characterized by greater pulsatility. Moreover, the negative correlation between the high FSQ risk score and the cold-induced ONH blood flow reduction was pronounced in eyes with NTG (correlation coefficient = -0.41). CONCLUSIONS: The FSQ risk score can be a screening tool to identify patients with POAG with increased vascular stiffness and further reduced ONH blood flow during cold stress. TRANSLATIONAL RELEVANCE: The vascular risk score may help tailor individual glaucoma care.
Proteome-Wide Analysis of Autoantibodies in Open-Angle Glaucoma in Japanese Population: A Pilot Study. International-journal

Naoko Takada, Makoto Ishikawa, Kota Sato, Hiroshi Kunikata, Takahiro Ninomiya, Akiko Hanyuda, Eriko Fukuda, Kei Yamaguchi, Chihiro Ono, Tomoko Kirihara, Chie Shintani, Chihiro Tsusu, Aki Osanai, Naoki Goshima, Yukitoshi Izumi, Charles F Zorumski, Toru Nakazawa

Biomedicines　13　(3)　2025/03/14

DOI： 10.3390/biomedicines13030718 　

eISSN： 2227-9059
Detection of Glaucomatous Visual Fields Using a Newly Developed Device with Retinal Projection Technology.

Satoru Tsuda, Hiroshi Kunikata, Makoto Ishikawa, Airi Takagi, Takeshi Yabana, Mitsuru Suzuki, Mitsuru Sugawara, Seiji Morino, Toru Nakazawa

The Tohoku journal of experimental medicine　2025/02/27

DOI： 10.1620/tjem.2025.J032 　
A hybrid multi model artificial intelligence approach for glaucoma screening using fundus images. International-journal

Parmanand Sharma, Naoki Takahashi, Takahiro Ninomiya, Masataka Sato, Takehiro Miya, Satoru Tsuda, Toru Nakazawa

NPJ digital medicine　8　(1)　130-130　2025/02/27

DOI： 10.1038/s41746-025-01473-w 　

ISSN： 2398-6352

eISSN： 2398-6352
Precise Generation of Human Induced Pluripotent Stem Cell-derived Cell Lines Harboring Disease-relevant Single Nucleotide Variants Using a Prime Editing System. International-journal

Seiya Kanno, Kota Sato, Toru Nakazawa

Bio-protocol　15　(4)　e5191　2025/02/20

DOI： 10.21769/BioProtoc.5191 　

eISSN： 2331-8325
Systemic oxidative stress levels and their associations with the risk of neovascular age-related macular degeneration and treatment response. International-journal

Maiko Abe, Hiroshi Kunikata, Naoko Aizawa, Masayuki Yasuda, Fumihiko Nitta, Toshiaki Abe, Toru Nakazawa

International journal of retina and vitreous　11　(1)　16-16　2025/02/10

DOI： 10.1186/s40942-025-00632-1 　

eISSN： 2056-9920
Glaucoma detection in myopic eyes using deep learning autoencoder-based regions of interest. International-journal

Christopher Bowd, Akram Belghith, Mark Christopher, Makoto Araie, Aiko Iwase, Goji Tomita, Kyoko Ohno-Matsui, Hitomi Saito, Hiroshi Murata, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Toru Nakazawa, Makoto Aihara, Tae-Woo Kim, Christopher Kai Shun Leung, Robert N Weinreb, Linda M Zangwill

Frontiers in ophthalmology　5　1624015-1624015　2025

DOI： 10.3389/fopht.2025.1624015 　

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PURPOSE: To evaluate the diagnostic accuracy of a deep learning autoencoder-based model utilizing regions of interest (ROI) from optical coherence tomography (OCT) texture enface images for detecting glaucoma in myopic eyes. METHODS: This cross-sectional study included a total of 453 eyes from 315 participants from the multi-center "Swept-Source OCT (SS-OCT) Myopia and Glaucoma Study", composed of 268 eyes from 168 healthy individuals and 185 eyes from 147 glaucomatous individuals. All participants underwent swept-source optical coherence tomography (SS-OCT) imaging, from which texture enface images were constructed and analyzed. The study compared four methods: (1) global RNFL thickness, (2) texture enface image, (3) a single autoencoder model trained only on healthy eyes, and (4) a dual autoencoder model trained on both healthy and glaucomatous eyes. Diagnostic accuracy was assessed using the area under the receiver operating curves (AUROC) and precision recall curves (AUPRC). RESULTS: The dual autoencoder model achieved the highest AUROC (95% CI) (0.92 [0.88, 0.95]), significantly outperforming the single autoencoder model trained only on healthy eyes (0.86 [0.83, 0.88], p = 0.01), the global RNFL thickness model (0.84 [0.80, 0.86], p = 0.003), and the texture enface model (0.83 [0.79, 0.85], p = 0.005). Using AUPRC (95% CI), the dual autoencoder model (0.86 [0.83, 0.89]) also outperformed the single autoencoder model trained only on healthy eyes (0.80 [0.78, 0.82], p = 0.02), the global RNFL thickness model (0.74 [0.70, 0.76], p = 0.001), and the texture enface model (0.71 [0.68, 0.73], p<0.001). No significant difference was observed between the global RNFL thickness measurement and the texture enface measurement (p = 0.47). DISCUSSION: The dual autoencoder model, which integrates reconstruction errors from both healthy and glaucomatous training data, demonstrated superior diagnostic accuracy compared to the single autoencoder model, global RNFL thickness and texture enface-based approaches. These findings suggest that deep learning models leveraging ROI-based reconstruction error from texture enface images may enhance glaucoma classification in myopic eyes, providing a robust alternative to conventional structural thickness metrics.
Influence of artificial intelligence on ophthalmologists' judgments in glaucoma. International-journal

Kenji Kashiwagi, Masahiro Toyoura, Xiaoyang Mao, Kazuhide Kawase, Masaki Tanito, Toru Nakazawa, Atsuya Miki, Kazuhiko Mori, Takeshi Yoshitomi

PloS one　20　(4)　e0321368　2025

DOI： 10.1371/journal.pone.0321368 　

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PURPOSE: To examine the influence of artificial intelligence (AI) on physicians' judgments regarding the presence and severity of glaucoma on fundus photographs in an online simulation system. METHODS: Forty-five trainee and expert ophthalmologists independently evaluated 120 fundus photographs, including 30 photographs each from patients with no glaucoma, mild glaucoma, moderate glaucoma, and severe glaucoma. A second trial was conducted at least one week after the initial trial in which photograph presentation order was randomized. During the second trial, 30% of the glaucoma judgments made by the AI system were intentionally incorrect. The evaluators were asked about their thoughts on AI in ophthalmology via a 3-item questionnaire. RESULTS: The percentage of correct responses for all images significantly improved (P < 0.001) from 48.4 ± 24.8% in the initial trial to 59.6 ± 20.3% in the second trial. The improvement in the correct response rate was significantly greater for trainees (14.2 ± 19.0%) than for experts (8.6 ± 11.4%) (P = 0.04). The correct response rate was 63.9 ± 20.6% when the AI response was correct, significantly greater than the 47.9 ± 26.6% when the AI response was incorrect (P < 0.0001). For trainees, the correct response rate was significantly greater when the AI's response was correct than when it was incorrect. However, for experts, the effect was less pronounced. The decision time was significantly longer when the AI response was incorrect than when it was correct (P = 0.003). CONCLUSION: In fundus photography-based glaucoma detection, the results of AI systems can influence physicians' judgments, particularly those of physicians with less experience.
Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma

Santiago Diaz-Torres, Weixiong He, Regina Yu, Anthony P. Khawaja, Christopher J. Hammond, Pirro G. Hysi, Louis R. Pasquale, Yeda Wu, Michiaki Kubo, Masato Akiyama, Tin Aung, Ching-Yu Cheng, Chiea Chuen Khor, Peter Kraft, Jae H. Kang, Alex W. Hewitt, David A. Mackey, Jamie E. Craig, Janey L. Wiggs, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani, Xikun Han, Andrew R. Hamel, Terri L. Young, Andrew J. Lotery, Eric Jorgenson, Helene Choquet, Michael Hauser, Jessica N. Cooke Bailey, Toru Nakazawa, Yukihiro Shiga, Ayellet V. Segre

NATURE COMMUNICATIONS　15　(1)　2024/11/17

DOI： 10.1038/s41467-024-54301-2 　

eISSN： 2041-1723
Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study. International-journal

Akiko Hanyuda, Yoshihiko Raita, Takahiro Ninomiya, Kazuki Hashimoto, Naoko Takada, Kota Sato, Jin Inoue, Seizo Koshiba, Gen Tamiya, Akira Narita, Masato Akiyama, Kazuko Omodaka, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Yasuko Yamamoto, Takazumi Taniguchi, Kazuno Negishi, Toru Nakazawa

Investigative ophthalmology & visual science　65　(13)　44-44　2024/11/04

DOI： 10.1167/iovs.65.13.44 　

ISSN： 0146-0404

eISSN： 1552-5783
Relationship between corneal hysteresis and the site of damage to peripapillary retinal nerve fibre layer thickness in open-angle glaucoma. International-journal

Yoko Takeda, Akiko Hanyuda, Naoki Takahashi, Kazuko Omodaka, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Airi Takagi, Toru Nakazawa

Scientific reports　14　(1)　26329-26329　2024/11/01

DOI： 10.1038/s41598-024-76187-2 　

ISSN： 2045-2322
Systemic Oxidative Stress Level as a Pathological and Prognostic Factor in Myopic Choroidal Neovascularization International-journal

Jiying Wang, Hiroshi Kunikata, Masayuki Yasuda, Noriko Himori, Fumihiko Nitta, Toru Nakazawa

Ophthalmology Science　4　(6)　100550-100550　2024/11/01

DOI： 10.1016/j.xops.2024.100550 　

eISSN： 2666-9145
Estrogen, via ESR2 receptor, prevents oxidative stress-induced Müller cell death and stimulates FGF2 production independently of NRF2, attenuating retinal degeneration. International-journal

Hiroshi Tawarayama, Keiko Uchida, Hirokazu Hasegawa, Masaaki Yoshida, Maki Inoue-Yanagimachi, Wataru Sato, Noriko Himori, Masayuki Yamamoto, Toru Nakazawa

Experimental eye research　248　110103-110103　2024/09/18

DOI： 10.1016/j.exer.2024.110103 　

ISSN： 0014-4835

eISSN： 1096-0007
Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals.

Nobuo Fuse, Masae Kimura, Ai Shimizu, Seizo Koshiba, Teruhiko Hamanaka, Makoto Nakamura, Nobuo Ishida, Hiroshi Sakai, Yoko Ikeda, Kazuhiko Mori, Atsushi Endo, Masao Nagasaki, Fumiki Katsuoka, Jun Yasuda, Yoichi Matsubara, Toru Nakazawa, Masayuki Yamamoto

Japanese journal of ophthalmology　68　(6)　688-701　2024/08/19

DOI： 10.1007/s10384-024-01103-0 　

ISSN： 0021-5155

eISSN： 1613-2246
Differentiating optic neuropathies using laser speckle flowgraphy: Evaluating blood flow patterns in the optic nerve head and peripapillary choroid. International-journal

Chiaki Yamaguchi, Naoki Kiyota, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

Acta ophthalmologica　103　(1)　e49-e57-e57　2024/08/13

DOI： 10.1111/aos.16747 　

ISSN： 1755-375X

eISSN： 1755-3768
Development of a Low-Cost Scanning Laser Ophthalmoscope Using Semiconductor Laser Technology.

Hiroki Takizawa, Hiroshi Kunikata, Takeshi Yabana, Masataka Sato, Takahiro Ninomiya, Neelam Kaushik, Sharma Parmanand, Noriko Himori, Mitsuru Sugawara, Seiji Morino, Makoto Suzuki, Makoto Ishikawa, Toru Nakazawa

The Tohoku journal of experimental medicine　265　(1)　39-45　2024/08/01

DOI： 10.1620/tjem.2024.J072 　

ISSN： 0040-8727

eISSN： 1349-3329
Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals. International-journal

Masato Akiyama, Gen Tamiya, Kohta Fujiwara, Yukihiro Shiga, Yu Yokoyama, Kazuki Hashimoto, Masataka Sato, Kota Sato, Akira Narita, Sawako Hashimoto, Emi Ueda, Yoshihiko Furuta, Jun Hata, Masahiro Miyake, Hanako O Ikeda, Kenji Suda, Shogo Numa, Yuki Mori, Kazuya Morino, Yusuke Murakami, Sakurako Shimokawa, Shun Nakamura, Nobuyo Yawata, Kimihiko Fujisawa, Satoshi Yamana, Kenichiro Mori, Yasuhiro Ikeda, Kazunori Miyata, Keisuke Mori, Ken Ogino, Yoshito Koyanagi, Yoichiro Kamatani, Toshiharu Ninomiya, Koh-Hei Sonoda, Toru Nakazawa

Ophthalmology　131　(11)　1271-1280　2024/07/17

DOI： 10.1016/j.ophtha.2024.05.026 　

ISSN： 0161-6420

eISSN： 1549-4713
Ocular blood flow dynamics following sinus rhythm restoration through catheter ablation: laser speckle flowgraphy in patients with persistent atrial fibrillation. International-journal

Nobuhiko Yamamoto, Makoto Nakano, Kotaro Nochioka, Masayuki Yasuda, Hiroshi Kunikata, Toru Nakazawa, Satoshi Yasuda

European heart journal. Imaging methods and practice　2　(3)　qyae071　2024/07

DOI： 10.1093/ehjimp/qyae071 　

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AIMS: Laser speckle flowgraphy (LSFG) is a well-established tool renowned for its non-invasive and reproducible assessment of ocular blood flow. While rhythm control therapies, such as catheter ablation (CA), have shown promise in enhancing cognitive function in atrial fibrillation (AF) patients, the acute impact of CA on microcirculatory changes, particularly in ocular blood flow, remains a topic of limited understanding. The present study aims to delve into the potential of LSFG in detecting microcirculatory alterations following the restoration of sinus rhythm (SR) through CA in patients with AF. METHODS AND RESULTS: We studied 8 paroxysmal AF (Paf) and 20 persistent AF (PeAF) patients (mean age 67 ± 6 years, 26% female) undergoing CA. Ocular blood flow was assessed using LSFG by measuring the mean blur rate (MBR) pre- and post-CA. Post-CA, all PeAF patients achieved SR restoration, resulting in a significant increase in tissue MBR (10.0 ± 2.2 to 10.8 ± 2.9, P = 0.021). In contrast, Paf patients showed no significant difference between pre- and post-MBR (12.0 ± 2.7 vs. 11.8 ± 2.6, P = 0.76). CONCLUSION: LSFG analysis effectively identified microcirculatory changes in patients undergoing CA for PeAF, suggesting that therapeutic interventions targeting the heart may have broader implications for ocular and cerebral health, establishing a novel 'cardio-oculo-cerebral relationship'.
SH-SY5Y human neuronal cells with mutations of the CDKN2B-AS1 gene are vulnerable under cultured conditions International-journal

Michiko Ohno-Oishi, Zou Meiai, Kota Sato, Seiya Kanno, Chihiro Kawano, Makoto Ishikawa, Toru Nakazawa

Biochemistry and Biophysics Reports　38　101723-101723　2024/07

DOI： 10.1016/j.bbrep.2024.101723 　

eISSN： 2405-5808
Relationship between oxidative stress level and diabetic retinopathy severity. International-journal

Tatsu Okabe, Hiroshi Kunikata, Masayuki Yasuda, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　262　(12)　4017-4020　2024/06/29

DOI： 10.1007/s00417-024-06563-1 　

ISSN： 0721-832X

eISSN： 1435-702X
The relationship between equol production status and normal tension glaucoma. International-journal

Noriko Himori, Keiko Uchida, Takahiro Ninomiya, Masashi Nagai, Kota Sato, Satoru Tsuda, Kazuko Omodaka, Toru Nakazawa

International ophthalmology　44　(1)　287-287　2024/06/27

DOI： 10.1007/s10792-024-03225-3 　

ISSN： 0165-5701

eISSN： 1573-2630
Effectiveness of remote risk-based monitoring and potential benefits for combination with direct data capture. International-journal

Osamu Yamada, Shih-Wei Chiu, Toru Nakazawa, Satoru Tsuda, Mitsuhide Yoshida, Toshifumi Asano, Taiki Kokubun, Kazuki Hashimoto, Munenori Takata, Suzuka Ikeda, Yosuke Kawabe, Yuko Tamura, Takuhiro Yamaguchi

Trials　25　(1)　384-384　2024/06/14

DOI： 10.1186/s13063-024-08242-2 　

eISSN： 1745-6215
A survey of Initial electroretinogram (ERG) examination for Acute Retinal Necrosis (ARN) in multi-center study

Kazuichi Maruyama, Shunichi Fukuyama, Masaaki Yoshida, Hiroaki Ushida, Kazuki Hashimoto, Noriyasu Hashida, Toru Nakazawa, Koji Miura Nishiguchi, Kohji Nishida

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
Differentiating optic neuropathies using laser speckle flowgraphy by evaluating blood flow patterns

Chiaki Yamaguchi, Naoki Kiyota, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
Two cases of primary open-angle glaucoma with a rare variant of the MYOC gene

Reimi Soma, Kazuki Hashimoto, Kota Sato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
Correlation Between Corneal Hysteresis and Optic Nerve Head Tissue Blood Flow in Eyes with Glaucoma

Yoko Takeda, Naoki Takahashi, Akiko Hanyuda, Kazuko Omodaka, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
Uric acid -driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation

Hongliang Lin, Yongjie Qin, Kota Sato, Toru Nakazawa, Hongyang Zhang

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
Association between the central visual field and papillomacular bundle in open -angle glaucoma

Naoki Sugita, Naoki Takahashi, Takako Omodaka, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
Detection of cataract with MEOCHECK, a simple visual field measurement device using retinal projection technology

Tadashi Nakashima, Takeshi Yabana, Masataka Sato, Takahiro Ninomiya, Mai Yamazaki, Noriko Himori, Morino Seiji, Makoto Suzuki, Satoru Tsuda, Yu Yokoyama, Makoto Ishikawa, Hiroshi Kunikata, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
Phase 2a study of calpain inhibitor SJP-0008 for central retinal artery occlusion

Satoru Tsuda, Hiroshi Kunikata, Kazuki Hashimoto, Toshifumi Asano, Azusa Ito, Taiki Kokubun, Yoshida Mitsuhide, Masayuki Yasuda, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
1%ドルゾラミド点眼後に漿液性網膜剥離が消失した視神経乳頭コロボーマの1例

藤岡俊亮, 吉田清香, 檜森紀子, 竹下孝之, 内田惠子, 山田晃生, 中澤徹, 野呂充

眼科臨床紀要　17　(6)　493-493　2024/06
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Comparative features of superior versus inferior hemisphere microvasculature dropout in open-angle glaucoma.

Naoki Takahashi, Kazuko Omodaka, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Toru Nakazawa

Japanese journal of ophthalmology　68　(4)　311-320　2024/05/30

DOI： 10.1007/s10384-024-01071-5 　

ISSN： 0021-5155

eISSN： 1613-2246
Retinal Layer Segmentation Using 1D+2D U-Net from OCT Images

Tsubasa Konno, Takahiro Ninomiya, Kanta Miura, Koichi Ito, Noriko Himori, Parmanand Sharma, Toru Nakazawa, Takafumi Aoki

2024 IEEE International Symposium on Biomedical Imaging (ISBI)　1-5　2024/05/27

DOI： 10.1109/isbi56570.2024.10635426 　

ISSN： 1945-7928

eISSN： 1945-8452
Changes in ocular blood flow in patients with neovascular age-related macular degeneration after intravitreal injection of ranibizumab biosimilar and brolucizumab. International-journal

Hiroki Takizawa, Masayuki Yasuda, Keisuke Hoshi, Tatsu Okabe, Hiroshi Kunikata, Toru Nakazawa

International ophthalmology　44　(1)　181-181　2024/04/16

DOI： 10.1007/s10792-024-03107-8 　

ISSN： 0165-5701

eISSN： 1573-2630
Efficacy and safety of first-line or second-line selective laser trabeculoplasty for normal-tension glaucoma: a multicentre cohort study

Koji Nitta, Kae Sugihara, Akiko Narita, Tomoko Naito, Takako Miki, Maki Katai, Shiro Mizoue, Keiji Yoshikawa, Masaki Tanito, Kazuhisa Sugiyama, Koji Nitta, Kae Sugihara, Akiko Narita, Tomoko Naito, Takako Miki, Maki Katai, Shiro Mizoue, Keiji Yoshikawa, Masaki Tanito, Kazuhisa Sugiyama, Yasushi Ikuno, Takuji Matsuda, Hiroaki Ozaki, Kazuyuki Hirooka, Kaori Komatsu, Yoshiaki Saito, Itaru Kimura, Tairo Kimura, Takeshi Sagara, Katsuyoshi Suzuki, Aika Tsutsui, Akiko Ishida, Toru Nakazawa, Satoru Tsuda, Toyoaki Tsumura, Naoki Tojo, Naoto Tokuda, Tadashi Nakano, Tomoyuki Watanabe, Kenji Nakamoto, Naka Shiratori, Mami Nanno, Naoya Nezu, Yoshitaka Tasaka, Shigeru Mori, Shigeki Yamabayashi, Kimihito Konno, Miyuki Domoto

BMJ Open Ophthalmology　9　(1)　2024/04/15

DOI： 10.1136/bmjophth-2023-001563 　

eISSN： 2397-3269
Sector-specific association of intraocular pressure dynamics in dark-room prone testing and visual field defect progression in glaucoma. International-journal

Masataka Sato, Naoki Kiyota, Takeshi Yabana, Shigeto Maekawa, Satoru Tsuda, Kazuko Omodaka, Noriko Himori, Yu Yokoyama, Toru Nakazawa

Ophthalmology. Glaucoma　7　(4)　372-379　2024/03/28

DOI： 10.1016/j.ogla.2024.03.007 　

ISSN： 2589-4234

eISSN： 2589-4196
Disease-specific variant interpretation highlighted the genetic findings in 2325 Japanese patients with retinitis pigmentosa and allied diseases. International-journal

Kensuke Goto, Yoshito Koyanagi, Masato Akiyama, Yusuke Murakami, Masatoshi Fukushima, Kohta Fujiwara, Hanae Iijima, Mitsuyo Yamaguchi, Mikiko Endo, Kazuki Hashimoto, Masataka Ishizu, Toshiaki Hirakata, Kei Mizobuchi, Masakazu Takayama, Junya Ota, Ai Fujita Sajiki, Taro Kominami, Hiroaki Ushida, Kosuke Fujita, Hiroki Kaneko, Shinji Ueno, Takaaki Hayashi, Chikashi Terao, Yoshihiro Hotta, Akira Murakami, Kazuki Kuniyoshi, Shunji Kusaka, Yuko Wada, Toshiaki Abe, Toru Nakazawa, Yasuhiro Ikeda, Yukihide Momozawa, Koh-Hei Sonoda, Koji M Nishiguchi

Journal of medical genetics　61　(7)　613-620　2024/03/18

DOI： 10.1136/jmg-2023-109750 　

ISSN： 0022-2593

eISSN： 1468-6244
Uric acid-driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation. International-journal

Hong Liang Lin, Sheng Wang, Kota Sato, Yu Qiao Zhang, Bei Ting He, Jing Xu, Toru Nakazawa, Yong Jie Qin, Hong Yang Zhang

Cell death discovery　10　(1)　126-126　2024/03/09

DOI： 10.1038/s41420-024-01900-z 　

eISSN： 2058-7716
Mobile infrared slit-light scanner for rapid eye disease screening. International-journal

Neelam Kaushik, Parmanand Sharma, Noriko Himori, Takuro Matsumoto, Takehiro Miya, Toru Nakazawa

Journal of medical imaging (Bellingham, Wash.)　11　(2)　026003-026003　2024/03

DOI： 10.1117/1.JMI.11.2.026003 　

ISSN： 2329-4302

eISSN： 2329-4310
Effects of deep optic nerve head structures on Bruch's membrane opening- minimum rim width and peripapillary retinal nerve fiber layer. International-journal

Mitsuki Kambayashi, Hitomi Saito, Makoto Araie, Nobuko Enomoto, Hiroshi Murata, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Aiko Iwase, Goji Tomita, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M Zangwill, Robert N Weinreb

American journal of ophthalmology　263　99-108　2024/02/23

DOI： 10.1016/j.ajo.2024.02.017 　

ISSN： 0002-9394

eISSN： 1879-1891
Vitreous Surgery for Giant Temporal Intrachoroidal Cavitation. International-journal

Chiaki Yamaguchi, Hiroshi Kunikata, Toru Nakazawa

Ophthalmic surgery, lasers & imaging retina　55　(4)　1-4　2024/02/01

DOI： 10.3928/23258160-20240117-03 　

ISSN： 2325-8160

eISSN： 2325-8179
Author Correction: Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. International-journal

Kota Sato, Daisuke Saigusa, Taiki Kokubun, Amane Fujioka, Qiwei Feng, Ritsumi Saito, Akira Uruno, Naomi Matsukawa, Michiko Ohno-Oishi, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Shigeto Maekawa, Masayuki Yamamoto, Toru Nakazawa

npj aging　10　(1)　8-8　2024/01/20

DOI： 10.1038/s41514-024-00137-5 　

eISSN： 2731-6068
The Effect of β-Blocker Eye Drops on Pulse Rate, Ocular Blood Flow, and Glaucoma Progression: A Retrospective Longitudinal Study. International-journal

Naoki Kiyota, Yukihiro Shiga, Takahiro Ninomiya, Satoru Tsuda, Kazuko Omodaka, Noriko Himori, Yu Yokoyama, Kyongsun Pak, Toru Nakazawa

Advances in therapy　41　(2)　730-743　2024/01/02

DOI： 10.1007/s12325-023-02762-0 　

ISSN： 0741-238X

eISSN： 1865-8652
The Relationship Between Artificial Intelligence-Assisted OCT Angiography-Derived Foveal Avascular Zone Parameters and Visual-Field Defect Progression in Eyes with Open-Angle Glaucoma. International-journal

Takahiro Ninomiya, Naoki Kiyota, Parmanand Sharma, Kazuko Omodaka, Noriko Himori, Masayuki Yasuda, Hiroshi Kunikata, Toru Nakazawa

Ophthalmology science　4　(2)　100387-100387　2024

DOI： 10.1016/j.xops.2023.100387 　

eISSN： 2666-9145
New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line

Kota Sato, Yuto Sasaki, Michiko Ohno-Oishi, Kuniyuki Kano, Junken Aoki, Kosuke Ohsawa, Takayuki Doi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Chihiro Kawano, Yoshiyuki Hirata, Toru Nakazawa

The Tohoku Journal of Experimental Medicine　263　(2)　151-160　2024
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2024.j024 　

ISSN： 0040-8727

eISSN： 1349-3329
Identification of OPTN p.(Asn51Thr): A novel pathogenic variant in primary open-angle glaucoma

Yukihiro Shiga, Kazuki Hashimoto, Kosuke Fujita, Shigeto Maekawa, Kota Sato, Shintaroh Kubo, Kazuhide Kawase, Kana Tokumo, Yoshiaki Kiuchi, Sotaro Mori, Makoto Nakamura, Takeshi Iwata, Koji M. Nishiguchi, Toru Nakazawa

Genetics in Medicine Open　2　100839-100839　2024
Publisher: Elsevier BV
DOI： 10.1016/j.gimo.2023.100839 　

ISSN： 2949-7744
A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction. International-journal

Nana Takahashi, Kota Sato, Naoki Kiyota, Satoru Tsuda, Namie Murayama, Toru Nakazawa

Scientific reports　13　(1)　22715-22715　2023/12/20

DOI： 10.1038/s41598-023-49598-w 　

eISSN： 2045-2322
Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography International-journal

Hiroshi Komatsu, Goh Onoguchi, Steven M. Silverstein, Stefan Jerotic, Atsushi Sakuma, Nobuhisa Kanahara, Yoshihisa Kakuto, Takashi Ono, Takeshi Yabana, Toru Nakazawa, Hiroaki Tomita

Molecular Psychiatry　29　(2)　464-482　2023/12/11
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41380-023-02340-4 　

ISSN： 1359-4184

eISSN： 1476-5578
Baseline characteristics associated with the incidence of intraocular inflammation after the intravitreous injection of brolucizumab. International-journal

Keisuke Hoshi, Hiroshi Kunikata, Naoko Aizawa, Masayuki Yasuda, Tatsu Okabe, Hiroki Takizawa, Toshiaki Abe, Toru Nakazawa

International ophthalmology　43　(12)　4701-4709　2023/12

DOI： 10.1007/s10792-023-02870-4 　

ISSN： 0165-5701

eISSN： 1573-2630
Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. International-journal

Kota Sato, Daisuke Saigusa, Taiki Kokubun, Amane Fujioka, Qiwei Feng, Ritsumi Saito, Akira Uruno, Naomi Matsukawa, Michiko Ohno-Oishi, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Shigeto Maekawa, Masayuki Yamamoto, Toru Nakazawa

npj aging　9　(1)　28-28　2023/11/21

DOI： 10.1038/s41514-023-00124-2 　

eISSN： 2731-6068
The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury International-journal

Kota Sato, Michiko Ohno-Oishi, Masaaki Yoshida, Taimu Sato, Takaharu Aizawa, Yuto Sasaki, Shigeto Maekawa, Makoto Ishikawa, Kazuko Omodaka, Chihiro Kawano, Ryuji Ohue-Kitano, Ikuo Kimura, Toru Nakazawa

GLIA　71　(11)　2609-2622　2023/11

DOI： 10.1002/glia.24442 　

ISSN： 0894-1491

eISSN： 1098-1136
Relationship between nailfold capillaroscopy parameters and the severity of diabetic retinopathy. International-journal

Tatsu Okabe, Hiroshi Kunikata, Masayuki Yasuda, Shinjiro Kodama, Yuta Maeda, Joe Nakano, Dan Takeno, Nobuo Fuse, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　262　(3)　759-768　2023/10/24

DOI： 10.1007/s00417-023-06220-z 　

ISSN： 0721-832X

eISSN： 1435-702X
The association between intraocular pressure dynamics during dark-room prone testing and intraocular pressure over a relatively long-term follow-up period in primary open-glaucoma patients. International-journal

Masataka Sato, Naoki Kiyota, Takeshi Yabana, Shigeto Maekawa, Satoru Tsuda, Kazuko Omodaka, Noriko Himori, Yu Yokoyama, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　262　(3)　949-956　2023/10/21

DOI： 10.1007/s00417-023-06257-0 　

ISSN： 0721-832X

eISSN： 1435-702X
Factors associated with intrachoroidal cavitation and sinkhole formation in eyes with glaucomatous visual-field defects. International-journal

Chiaki Yamaguchi, Naoki Kiyota, Naoki Takahashi, Yoko Takeda, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　262　(2)　557-566　2023/10/04

DOI： 10.1007/s00417-023-06247-2 　

ISSN： 0721-832X

eISSN： 1435-702X
Predictive potential of optical coherence tomography parameters for the prognosis of decreased visual acuity after trabeculectomy in open-angle glaucoma patients with good vision. International-journal

Yoko Takeda, Naoki Takahashi, Naoki Kiyota, Taiki Kokubun, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Toru Nakazawa

BMC ophthalmology　23　(1)　399-399　2023/10/04

DOI： 10.1186/s12886-023-03145-3 　

eISSN： 1471-2415
Association of Bergmeister's papilla and deep optic nerve head structures with prelaminar schisis of normal and glaucomatous eyes. International-journal

Hitomi Saito, Takashi Ueta, Makoto Araie, Nobuko Enomoto, Mitsuki Kambayashi, Hiroshi Murata, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Aiko Iwase, Goji Tomita, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M Zangwill, Robert N Weinreb

American journal of ophthalmology　257　91-102　2023/09/07

DOI： 10.1016/j.ajo.2023.09.002 　

ISSN： 0002-9394

eISSN： 1879-1891
Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells. International-journal

Hiroshi Tawarayama, Kota Umeki, Maki Inoue-Yanagimachi, Naoki Takahashi, Hirokazu Hasegawa, Noriko Himori, Satoru Tsuda, Hiroshi Kunikata, Takaaki Akaike, Toru Nakazawa

Scientific reports　13　(1)　11513-11513　2023/07/17

DOI： 10.1038/s41598-023-38696-4 　

eISSN： 2045-2322
Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients. International-journal

Nana Takahashi, Naoki Kiyota, Hiroshi Kunikata, Mai Yamazaki, Takayuki Nishimura, Yukihiro Shiga, Hisae Aoyagi, Miwako Shidomi, Tomohiro Tsuda, Toshihiko Ohtsuka, Takahiro Tomida, Toru Nakazawa

BMC ophthalmology　23　(1)　316-316　2023/07/12

DOI： 10.1186/s12886-023-03059-0 　

eISSN： 1471-2415
The relationship between Kiritsu-Meijin-derived autonomic function parameters and visual-field defects in eyes with open-angle glaucoma. International-journal

Yurina Yamada, Naoki Kiyota, Mitsuhide Yoshida, Kazuko Omodaka, Toru Nakazawa

Current eye research　48　(11)　1-12　2023/07/05

DOI： 10.1080/02713683.2023.2234105 　

ISSN： 0271-3683

eISSN： 1460-2202
Factors Associated With Visual Acuity Decline in Glaucoma Patients With Loss of Ganglion Cell Complex Thickness. International-journal

Naoki Takahashi, Kazuko Omodaka, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Noriko Himori, Toru Nakazawa

Translational vision science & technology　12　(7)　2-2　2023/07/03

DOI： 10.1167/tvst.12.7.2 　

eISSN： 2164-2591
DPP-4 Inhibitors Attenuate Fibrosis After Glaucoma Filtering Surgery by Suppressing the TGF-β/Smad Signaling Pathway. International-journal

Masaaki Yoshida, Taiki Kokubun, Kota Sato, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Toru Nakazawa

Investigative ophthalmology & visual science　64　(10)　2-2　2023/07/03

DOI： 10.1167/iovs.64.10.2 　

ISSN： 0146-0404

eISSN： 1552-5783
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci. International-journal

Xikun Han, Puya Gharahkhani, Andrew R Hamel, Jue Sheng Ong, Miguel E Rentería, Puja Mehta, Xianjun Dong, Francesca Pasutto, Christopher Hammond, Terri L Young, Pirro Hysi, Andrew J Lotery, Eric Jorgenson, Hélène Choquet, Michael Hauser, Jessica N Cooke Bailey, Toru Nakazawa, Masato Akiyama, Yukihiro Shiga, Zachary L Fuller, Xin Wang, Alex W Hewitt, Jamie E Craig, Louis R Pasquale, David A Mackey, Janey L Wiggs, Anthony P Khawaja, Ayellet V Segrè, Stuart MacGregor

Nature genetics　55　(7)　1116-1125　2023/06/29

DOI： 10.1038/s41588-023-01428-5 　

ISSN： 1061-4036

eISSN： 1546-1718
Preliminary evidence of the effects of a novel antioxidant supplement in reducing oxidative stress in patients with senile cataract. International-journal

Noriko Himori, Hiroshi Kunikata, Toru Nakazawa

International ophthalmology　43　(9)　3031-3034　2023/06/20

DOI： 10.1007/s10792-023-02728-9 　

ISSN： 0165-5701

eISSN： 1573-2630
Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma. International-journal

Kota Sato, Naoko Takada, Amane Fujioka, Noriko Himori, Yu Yokoyama, Satoru Tsuda, Kazuko Omodaka, Tomoko Kirihara, Makoto Ishikawa, Hiroshi Kunikata, Toru Nakazawa

Journal of glaucoma　32　(9)　734-737　2023/06/19

DOI： 10.1097/IJG.0000000000002257 　

ISSN： 1057-0829

eISSN： 1536-481X
Clinical Trial of Autologous Cultivated Limbal Epithelial Cell Sheet Transplantation for Patients with Limbal Stem Cell Deficiency. International-journal

Yoshinori Oie, Seiichiro Sugita, Shunji Yokokura, Toru Nakazawa, Daisuke Tomida, Yoshiyuki Satake, Jun Shimazaki, Yuko Hara, Atsushi Shiraishi, Andrew J Quantock, Takahiro Ogasawara, Masukazu Inoie, Kohji Nishida

Ophthalmology　130　(6)　608-614　2023/06

DOI： 10.1016/j.ophtha.2023.01.016 　

ISSN： 0161-6420

eISSN： 1549-4713
Utility of Laser Speckle Flowgraphy-derived Vascular Cloud for Differentiating Poor Image Quality Data

清田直樹, 志賀由己浩, 二宮高洋, 山口知暁, 面高宗子, 中澤徹

日本眼科学会雑誌　127　(5)　549-556　2023/05
Publisher:
ISSN： 0029-0203
Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina. International-journal

Yukitoshi Izumi, Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Douglas F Covey, Charles F Zorumski

Neural regeneration research　18　(5)　1004-1008　2023/05

DOI： 10.4103/1673-5374.355752 　

ISSN： 1673-5374

eISSN： 1876-7958
Long-Term Surgical Outcomes and Possible Postoperative Complication with Severe Corneal Endothelial Cell Loss After Trabeculectomy for Cytomegalovirus-Associated Anterior Uveitis with Secondary Glaucoma. International-journal

Masaaki Yoshida, Yu Yokoyama, Taiki Kokubun, Satoru Tsuda, Noriko Himori, Shigeto Maekawa, Shunji Yokokura, Takehiro Hariya, Wataru Kobayashi, Kazuki Hashimoto, Toru Nakazawa

Ocular immunology and inflammation　32　(5)　1-9　2023/04/24

DOI： 10.1080/09273948.2023.2197497 　

ISSN： 0927-3948

eISSN： 1744-5078
Retinal Layer Segmentation from Oct Images Using 2D-3D Hybrid Network with Multi-Scale Loss and Refinement Module

Tsubasa Konno, Takahiro Ninomiya, Kanta Miura, Koichi Ito, Noriko Himori, Parmanand Sharma, Toru Nakazawa, Takafumi Aoki

2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI)　2023-April　1-4　2023/04/18
Publisher: IEEE
DOI： 10.1109/isbi53787.2023.10230693 　

ISSN： 1945-7928

eISSN： 1945-8452
Specular microscopic examination of injured cornea by cervical venom gland of a snake, Rhabdophis tigrinus

山口万里奈, 山口万里奈, 高宮美智子, 横倉俊二, 國方彦志, 中澤徹

眼科臨床紀要　16　(4)　243-246　2023/04
Publisher:
ISSN： 1882-5176
Imaging and qualitative depth analysis with a portable nonmydriatic fundus camera using oblique illumination

Neelam Kaushik, Takashi Sasaki, Kana Takeyama, Kazuhiro Hane, Toru Nakazawa

Journal of Optical Microsystems　3　(2)　2023/04

DOI： 10.1117/1.JOM.3.2.024502 　

eISSN： 2708-5260
Association between myopia and complications of glaucoma with retinal diseases: investigation of a large medical insurance database. International-journal

Takahiro Ninomiya, Hiroshi Kunikata, Makoto Ishikawa, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　261　(8)　2431-2433　2023/03/17

DOI： 10.1007/s00417-023-06031-2 　

ISSN： 0721-832X

eISSN： 1435-702X
Effects of constitutively active K-Ras on axon regeneration after optic nerve injury. International-journal

Naoki Kiyota, Kazuhiko Namekata, Euido Nishijima, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Toru Nakazawa, Takayuki Harada

Neuroscience letters　799　137124-137124　2023/03/16

DOI： 10.1016/j.neulet.2023.137124 　

ISSN： 0304-3940

eISSN： 1872-7972
Innovation in Diagnosis and Treatment of Ocular Diseases by Applying Genomic Medicine

西口康二, 藤田幸輔, 小柳俊人, 佐治木愛, 川野健一, 山田和久, 川部満希, 奥田大志, 鈴村文那, 清水英幸, 牛田宏昭, 兼子裕規, 小松紘之, 臼井嘉彦, 後藤浩, 中澤徹, 加地秀

日本眼科学会雑誌　127　(3)　402-422　2023/03
Publisher:
ISSN： 0029-0203
Fabrication of anti-inflammatory nano eye-drops composed of dexamethasone prodrugs

Keita Tanita, Mai Iijima, Yoshitaka Koseki, Kota Sato, Toru Nakazawa, Hitoshi Kasai

Molecular Crystals and Liquid Crystals　1-7　2023/02/23
Publisher: Informa UK Limited
DOI： 10.1080/15421406.2023.2180212 　

ISSN： 1542-1406

eISSN： 1563-5287
Correction: Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis. International-journal

Hiroshi Komatsu, Goh Onoguchi, Stefan Jerotic, Nobuhisa Kanahara, Yoshihisa Kakuto, Takashi Ono, Shunichi Funakoshi, Takeshi Yabana, Toru Nakazawa, Hiroaki Tomita

Molecular psychiatry　28　(5)　2170　2023/02/09

DOI： 10.1038/s41380-023-01983-7 　

ISSN： 1359-4184

eISSN： 1476-5578
Deep optic nerve head structures associated with increasing axial length in healthy myopic eyes of moderate axial length. International-journal

Hitomi Saito, Mitsuki Kambayashi, Makoto Araie, Hiroshi Murata, Nobuko Enomoto, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Aiko Iwase, Goji Tomita, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M Zangwill, Robert N Weinreb

American journal of ophthalmology　249　156-166　2023/01/13

DOI： 10.1016/j.ajo.2023.01.003 　

ISSN： 0002-9394

eISSN： 1879-1891
Corrigendum: Glaucoma and microglia-induced neuroinflammation. International-journal

Makoto Ishikawa, Yukitoshi Izumi, Kota Sato, Taimu Sato, Charles F Zorumski, Hiroshi Kunikata, Toru Nakazawa

Frontiers in ophthalmology　3　1332312-1332312　2023

DOI： 10.3389/fopht.2023.1332312 　

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[This corrects the article DOI: 10.3389/fopht.2023.1132011.].
The effect of a brinzolamide/brimonidine fixed combination on optic nerve head blood flow in rabbits. International-journal

Nana Takahashi, Kota Sato, Naoki Kiyota, Mai Yamazaki, Eriko Kunikane, Toru Nakazawa

PloS one　18　(12)　e0295122　2023

DOI： 10.1371/journal.pone.0295122 　

eISSN： 1932-6203
A quality management system aiming to ensure regulatory-grade data quality in a glaucoma registry. International-journal

Shinsuke Wada, Satoru Tsuda, Maiko Abe, Toru Nakazawa, Hisashi Urushihara

PloS one　18　(6)　e0286669　2023

DOI： 10.1371/journal.pone.0286669 　

eISSN： 1932-6203
Sex differences in the association between systemic oxidative stress status and optic nerve head blood flow in normal-tension glaucoma. International-journal

Masataka Sato, Masayuki Yasuda, Nana Takahashi, Kazuki Hashimoto, Noriko Himori, Toru Nakazawa

PloS one　18　(2)　e0282047　2023

DOI： 10.1371/journal.pone.0282047 　

eISSN： 1932-6203
Familial Paget's disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27).

Akiko Saito-Hakoda, Atsuo Kikuchi, Tadahisa Takahashi, Yu Yokoyama, Noriko Himori, Mika Adachi, Ryoukichi Ikeda, Yuri Nomura, Jun Takayama, Junko Kawashima, Fumiki Katsuoka, Fumiyoshi Fujishima, Takehiko Yamaguchi, Akiyo Ito, Takushi Hanita, Junko Kanno, Toshimi Aizawa, Toru Nakazawa, Tetsuaki Kawase, Gen Tamiya, Masayuki Yamamoto, Ikuma Fujiwara, Shigeo Kure

Journal of bone and mineral metabolism　41　(2)　193-202　2022/12/15

DOI： 10.1007/s00774-022-01392-w 　

ISSN： 0914-8779

eISSN： 1435-5604
Genetic variants associated with glaucomatous visual field loss in primary open-angle glaucoma. International-journal

Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuki Hashimoto, Kota Sato, Yukihiro Shiga, Toru Nakazawa, Masato Akiyama, Kazuhide Kawase, Mineo Ozaki, Makoto Araie

Scientific reports　12　(1)　20744-20744　2022/12/01

DOI： 10.1038/s41598-022-24915-x 　

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Primary open-angle glaucoma (POAG) is characterized by a progressive optic neuropathy with visual field loss. To investigate the genetic variants associated with visual field loss in POAG, Japanese POAG patients (n = 426) and control subjects (n = 246) were genotyped for 22 genetic variants predisposing to POAG that can be classified into those associated with intraocular pressure (IOP) elevation (IOP-related genetic variants) and optic nerve vulnerability independent of IOP (optic nerve-related genetic variants). The genetic risk score (GRS) of the 17 IOP-related and five optic nerve-related genetic variants was calculated, and the associations between the GRS and the mean deviation (MD) of automated static perimetry as an indicator of the severity of visual field loss and pattern standard deviation (PSD) as an indicator of the focal disturbance were evaluated. There was a significant association (Beta = - 0.51, P = 0.0012) between the IOP-related GRS and MD. The severity of visual field loss may depend on the magnitude of IOP elevation induced by additive effects of IOP-related genetic variants. A significant association (n = 135, Beta = 0.65, P = 0.0097) was found between the optic nerve-related, but not IOP-related, GRS and PSD. The optic nerve-related (optic nerve vulnerability) and IOP-related (IOP elevation) genetic variants may play an important role in the focal and diffuse visual field loss respectively. To our knowledge, this is the first report to show an association between additive effects of genetic variants predisposing to POAG and glaucomatous visual field loss, including severity and focal/diffuse disturbance of visual field loss, in POAG.
Isozyme-specific Histone Deacetylase 1/2 Inhibitor K560 Attenuates Oxidative Stress-induced Retinal Cell Death. International-journal

Hiroshi Tawarayama, Yoshiyuki Hirata, Uchida Keiko, Noriko Himori, Shinichi Uesato, Toru Nakazawa

Neuroscience letters　793　136978-136978　2022/11/23

DOI： 10.1016/j.neulet.2022.136978 　

ISSN： 0304-3940

eISSN： 1872-7972
Changes in glial cells and neurotrophic factors due to rotenone-induced oxidative stress in Nrf2 knockout mice. International-journal

Maki Inoue-Yanagimachi, Noriko Himori, Keiko Uchida, Hiroshi Tawarayama, Kota Sato, Masayuki Yamamoto, Kazuhiko Namekata, Takayuki Harada, Toru Nakazawa

Experimental eye research　226　109314-109314　2022/11/15

DOI： 10.1016/j.exer.2022.109314 　

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Glaucoma is one of the most common causes of blindness worldwide. It is thought to be a multifactorial disease with underlying mechanisms that include mitochondrial dysfunction and oxidative stress. Here, we used NF-E2 related factor 2 (Nrf2) knockout (KO) mice, which are vulnerable to oxidative stress, to examine a neuroprotective effect against oxidative stress due to rotenone, a mitochondrial complex I inhibitor. Wild-type (WT) and Nrf2 KO mice received an oral solution of rotenone for 30 days. We then extracted the retinas and performed immunohistochemistry and quantitative RT-PCR. We also prepared a primary Müller cell culture of samples from each mouse, added 30 μM rotenone, and then measured cell viability, cytotoxicity and CellRox absorbance. We also examined gene expression. We found a significant increase in the number of 8-OHdG-positive retinal ganglion cells (RGCs) after rotenone administration in both the WT and Nrf2 KO mice. There was no difference in the number of RNA-binding protein with multiple splicing (RBPMS)-positive RGCs in the WT and Nrf2 KO mice, but Nrf2 KO mice that were given rotenone had significantly less retinal gene expression of RBPMS than Nrf2 KO mice given a control. Moreover, there was significantly higher mRNA gene expression of vimentin and glial fibrillary acidic protein (GFAP) in Nrf2 KO mice that received rotenone than WT mice that received rotenone. A statistical analysis of the in vitro experiment showed that cell viability was lower, cytotoxicity was higher, and oxidative stress was higher in the Müller cells of the Nrf2 KO mice than the WT mice. Finally, brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (bFGF) were significantly higher in the Müller cells of the Nrf2 KO mice than the WT mice. These findings suggest that in Nrf2 KO mice under oxidative stress caused by rotenone, temporary neurotrophic factors are secreted from the Müller cells, conferring neuroprotection in these cells.
Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides. International-journal

Hiroshi Kunikata, Hiroshi Tawarayama, Satoru Tsuda, Takaaki Akaike, Toru Nakazawa

Scientific reports　12　(1)　19243-19243　2022/11/10

DOI： 10.1038/s41598-022-21677-4 　

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Anti-oxidative intraocular irrigating solutions (IISs) based on reactive persulfides, such as oxidized glutathione disulfide (GSSG), are commonly used worldwide. However, even with GSSG-based IISs, it has been shown that oxidative stress can occur during surgery, posing a risk to intraocular tissues. This study compared two IISs: one containing GSSG and one containing an oxidized glutathione trisulfide (GSSSG). Experimental in vivo irrigation with the IISs in rabbits showed that there was less leakage into the anterior chamber of rabbit serum albumin during perfusion with a 300-μM GSSSG IIS than with a 300-μM GSSG IIS. Experimental in vivo cataract surgery in rabbits showed that aqueous flare was suppressed 3 days after surgery with a 600-μM GSSSG IIS, but not with a 300-μM GSSSG or 300-μM GSSG IIS. Furthermore, an in vitro experiment, without any live tissue, showed that reactive oxygen species were suppressed more strongly with a 600-μM GSSSG IIS than with a 300-μM GSSG IIS. Thus, this study found that novel IISs based on GSSSG had anti-inflammatory and anti-oxidative effects during and after intraocular surgery and may decrease the rate of complications after surgery.
Corneal rupture during cataract surgery in two cases with brittle cornea syndrome

山口万里奈, 山口万里奈, 高宮美智子, 國方彦志, 中澤徹

臨床眼科　76　(10)　1459-1464　2022/10
Publisher:
ISSN： 0370-5579

eISSN： 1882-1308
Deep Learning-Based Noise Reduction Improves Optical Coherence Tomography Angiography Imaging of Radial Peripapillary Capillaries in Advanced Glaucoma. International-journal

Kazuko Omodaka, Juun Horie, Hikari Tokairin, Chiho Kato, Junko Ouchi, Takahiro Ninomiya, Sharma Parmanand, Satoru Tsuda, Toru Nakazawa

Current eye research　47　(12)　1-9　2022/09/22

DOI： 10.1080/02713683.2022.2124275 　

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PURPOSE: We applied deep learning-based noise reduction (NR) to optical coherence tomography-angiography (OCTA) images of the radial peripapillary capillaries (RPCs) in eyes with glaucoma and investigated the usefulness of this method as an objective analysis of glaucoma. METHODS: This cross-sectional study included 118 eyes of 94 open-angle glaucoma patients (male/female = 38/56, age: 56.1 ± 10.3 years). We used OCTA (OCT-HS100, Canon) and built-in software (RX software, v. 4.5) to perform NR and calculate RPC vessel area density (VAD) and skeleton vessel length density (VLD). We also examined NR's effect on reproducibility. Finally, we assessed the vascular structure (PRCs)/function relationship at different glaucoma stages with Spearman's correlation. RESULTS: Regardless of NR, RPC parameters had excellent coefficients of variation (1.7-4.1%) in glaucoma patients and controls, and mean deviation (MD) was significantly correlated with VAD (NR: r = 0.835, p < 0.001; non-NR: r = 0.871, p < 0.001) and VLD (NR: r = 0.829, p < 0.001; non-NR: r = 0.837, p < 0.001). For mild, moderate, and advanced glaucoma, the correlation coefficients between MD and VLD were 0.366 (p = 0.028) 0.081 (p = 0.689), and 0.427 (p = 0.017) with NR and 0.405 (p = 0.014), 0.184 (p = 0.360), and 0.339 (p = 0.062) without NR, respectively. CONCLUSION: Denoised RPC images might have the potential for a closer structural/functional relationship, in which the floor effect of retinal nerve fiber layer thickness affects measurements. Deep learning-based NR promises to improve glaucoma assessment.
Clinical characteristics of glaucoma patients with various risk factors. International-journal

Kazuko Omodaka, Tsutomu Kikawa, Sayaka Kabakura, Noriko Himori, Satoru Tsuda, Takahiro Ninomiya, Naoki Takahashi, Kyongsun Pak, Noriyasu Takeda, Masahiro Akiba, Toru Nakazawa

BMC ophthalmology　22　(1)　373-373　2022/09/19

DOI： 10.1186/s12886-022-02587-5 　

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BACKGROUND: Glaucoma is multifactorial, but the interrelationship between risk factors and structural changes remains unclear. Here, we adjusted for confounding factors in glaucoma patients with differing risk factors, and compared differences in structure and susceptible areas in the optic disc and macula. METHODS: In 458 eyes with glaucoma, we determined confounding factors for intraocular pressure (IOP), central corneal thickness (CCT), axial length (AL), LSFG-measured ocular blood flow (OBF), which was assessed with laser speckle flowgraphy-measured mean blur rate in the tissue area (MT) of the optic nerve head, biological antioxidant potential (BAP), and systemic abnormalities in diastolic blood pressure (dBP). To compensate for measurement bias, we also analyzed corrected IOP (cIOP; corrected for CCT) and corrected MT (cMT; corrected for age, weighted retinal ganglion cell count, and AL). Then, we determined the distribution of these parameters in low-, middle-, and high-value subgroups and compared them with the Kruskal-Wallis test. Pairwise comparisons used the Steel-Dwass test. RESULTS: The high-cIOP subgroup had significantly worse mean deviation (MD), temporal, superior, and inferior loss of circumpapillary retinal nerve fiber layer thickness (cpRNFLT), and large cupping. The low-CCT subgroup had temporal cpRNFLT loss; the high-CCT subgroup had low cup volume. The high-AL subgroup had macular ganglion cell complex thickness (GCCT) loss; the low-AL subgroup had temporal cpRNFLT loss. The high-systemic-dBP subgroup had worse MD, total, superior, and inferior cpRNFLT loss and macular GCCT loss. The low-BAP subgroup had more male patients, higher dBP, and cpRNFLT loss in the 10 o'clock area. The high-OBF subgroup had higher total, superior and temporal cpRNFLT and macular GCCT. CONCLUSIONS: Structural changes and local susceptibility to glaucomatous damage show unique variations in patients with different risk factors, which might suggest that specific risk factors induce specific types of pathogenesis and corresponding glaucoma phenotypes. Our study may open new avenues for the development of precision medicine for glaucoma.
METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma. International-journal

Yang Pan, Akiko Suga, Itaru Kimura, Chojiro Kimura, Yuriko Minegishi, Mao Nakayama, Kazutoshi Yoshitake, Daisuke Iejima, Naoko Minematsu, Megumi Yamamoto, Fumihiko Mabuchi, Mitsuko Takamoto, Yukihiro Shiga, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Toru Nakazawa, Takeshi Iwata

The Journal of clinical investigation　132　(21)　2022/09/13

DOI： 10.1172/JCI153589 　

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Normal-tension glaucoma (NTG) is a heterogeneous disease characterized by retinal ganglion cell (RGC) death leading to cupping of the optic nerve head and visual field loss at normal intraocular pressure (IOP). The pathogenesis of NTG remains unclear. Here, we described a single nucleotide mutation in exon 2 of the methyltransferase like 23 (METTL23) gene identified in a three-generation Japanese NTG family. This mutation caused METTL23 mRNA aberrant splicing, which abolished normal protein production and altered subcellular localization. Mettl23 knock-in (Mettl23+/G & Mettl23G/G) and knockout (Mettl23+/- & Mettl23-/-) mice developed a glaucoma phenotype without elevated IOP. METTL23 is a histone arginine methyltransferase expressed in murine and macaque RGCs. However, the novel mutation reduced Mettl23 expression in RGCs of Mettl23G/G mice, which recapitulated both clinical and biological phenotypes. Moreover, our findings demonstrated that Mettl23 catalyzed the dimethylation of H3R17 in the retina, and was required for the transcription of pS2, an estrogen receptor α target gene that was critical to RGC homeostasis through the negative regulation of NF-κB-mediated TNF-α/IL-1β feedback. These findings suggest an etiologic role of METTL23 in NTG with tissue-specific pathology.
De novo Vogt-Koyanagi-Harada disease after vaccination for COVID-19, successfully treated with systemic steroid therapy and monitored with laser speckle flowgraphy. International-journal

Chiaki Yamaguchi, Hiroshi Kunikata, Kazuki Hashimoto, Masaaki Yoshida, Takahiro Ninomiya, Takehiro Hariya, Toshiaki Abe, Toru Nakazawa

American journal of ophthalmology case reports　27　101616-101616　2022/09

DOI： 10.1016/j.ajoc.2022.101616 　

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Purpose: Vogt-Koyanagi-Harada (VKH) disease after vaccination for coronavirus disease 2019 (COVID-19) is rare, and the prognosis for this condition and its effect on ocular blood flow remains unclear. The purpose of this paper is to present the first case of de novo VKH disease after the second vaccination for COVID-19 with an mRNA vaccine that was successfully treated with systemic steroid therapy and monitored with laser speckle flowgraphy (LSFG). Observations: A 30s-year-old Japanese woman reported bilateral decreased visual function 2 weeks after receiving a second dose of the BNT162b2 mRNA vaccine. Best-corrected visual acuity was 20/50 OD and 20/70 OS. Optical coherence tomography revealed bilateral serous retinal detachment over the swollen choroidal layer. LFSG showed decreased blood flow in the peripapillary region of both eyes. This case was diagnosed as complete VKH syndrome, and the patient underwent systemic steroid therapy. After treatment, the retinal detachment disappeared, choroidal thickness decreased, and ocular blood flow increased. Three months later, visual acuity recovered to 20/20 in both eyes. Conclusions: Caution should be exercised in cases with visual symptoms after COVID-19 vaccination, even after more than one dose and more than one week after vaccination. LSFG may be a useful way to measure the ocular blood flow response to treatment and determine the prognosis for VKH disease after COVID-19 vaccination.
The relationship between choroidal blood flow and glaucoma progression in a Japanese study population.

Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Japanese journal of ophthalmology　66　(5)　425-433　2022/09

DOI： 10.1007/s10384-022-00929-w 　

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PURPOSE: To determine whether choroidal blood flow (BF) is related to visual field (VF) defect severity and progression in eyes with open-angle glaucoma (OAG). STUDY DESIGN: Retrospective and longitudinal. METHODS: This study comprised 443 eyes of 285 OAG patients who underwent laser speckle flowgraphy (LSFG), optical coherence tomography, and visual-field (VF) testing at baseline. The patients were then observed for at least 2 years and at least 5 reliable VF tests were performed. In the LSFG images, we set regions of interest at the optic nerve head (ONH) and the parapapillary choroid to obtain ONH-tissue mean blur rate (MBR) and choroidal MBR, respectively. We used univariable and multivariable linear mixed-effects models to determine clinical factors associated with choroidal MBR at baseline. We also used a linear mixed-effects model to determine the contribution of ONH-tissue MBR and choroidal MBR to baseline mean deviation (MD) and to MD slope during follow-up, adjusting for potential confounding factors, including circumpapillary retinal nerve fiber layer thickness. RESULTS: Choroidal MBR was associated with age, MD slope, and ONH-tissue MBR (β = -0.181, P = 0.001; β = 0.134, P = 0.002; β = 0.096, P = 0.049, respectively). ONH-tissue MBR was associated with both MD and MD slope (β = 0.146, P = 0.004; β = 0.152, P = 0.009, respectively), whereas choroidal MBR was associated only with MD slope (β = 0.147, P = 0.005). CONCLUSION: LSFG-derived choroidal MBR might be a useful biomarker to predict VF defect progression in a Japanese population.
A Novel Development of Sarcoidosis following COVID-19 Vaccination and a Literature Review.

Tadahisa Numakura, Koji Murakami, Tsutomu Tamada, Chiaki Yamaguchi, Chihiro Inoue, Shinya Ohkouchi, Naoki Tode, Hirohito Sano, Hiroyuki Aizawa, Kei Sato, Ayumi Mitsune, Hajime Kurosawa, Toru Nakazawa, Hisatoshi Sugiura

Internal medicine (Tokyo, Japan)　61　(20)　3101-3106　2022/08/10

DOI： 10.2169/internalmedicine.0104-22 　

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BNT162b2 (Pfizer/BioNTech) is a coronavirus disease 2019 (COVID-19) vaccine containing nucleoside-modified messenger RNA encoding the severe acute respiratory syndrome coronavirus 2 spike glycoprotein. Recently, ocular complications of mRNA vaccines have been reported increasingly frequently. However, immunological adverse events due to mRNA vaccines in real-world settings are not fully known. We herein report the novel development of sarcoidosis manifested as uveitis, bilateral hilar lymphadenopathy, angiotensin-converting enzyme elevation, and epithelioid and giant cell granuloma formation in the lung soon after the first BNT162b2 injection and review the current literature, including three reported cases of sarcoid-like reaction following COVID-19 vaccination.
A Rare Case of Fungal Keratitis Caused by Plectosphaerella cucumerina Diagnosed With Repeated Corneal Scrapings: A Case Report. International-journal

Takuya Kiriyama, Takehiro Hariya, Masaaki Yoshida, Daisuke Todokoro, Toru Nakazawa

Cureus　14　(8)　e27628　2022/08

DOI： 10.7759/cureus.27628 　

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Plectosphaerella cucumerina is a filamentous fungus that infects plants and crops, but there are few previous reports of human infections. The current case was an 82-year-old woman who was referred to us for corneal infection in her left eye that did not improve with antibacterial and anti-inflammatory treatment. The best-corrected visual acuity (BCVA) of the eye at the first visit to us was hand motion. Slit-lamp examination revealed extensive white infiltration and ulceration in the anterior corneal stroma of the left eye. Intensive antibacterial and antiviral treatment for one month did not improve the condition of the cornea. Although initial culture testing and polymerase chain reaction (PCR) testing of corneal scraping samples did not reveal the causative microorganism, repeated culture testing identified P. cucumerina. The corneal infection eventually subsided after topical and systemic treatment with voriconazole (VRCZ). The final BCVA in the left eye was 1.3 logMAR. This was a rare case of fungal keratitis due to P. cucumerina. Our case suggests that it is important to perform repeated examinations with corneal scrapings, especially when the treatment response is poor.
Likely pathogenic structural variants in genetically unsolved patients with retinitis pigmentosa revealed by long-read sequencing. International-journal

Yusuke Sano, Yoshito Koyanagi, Jing Hao Wong, Yusuke Murakami, Kohta Fujiwara, Mikiko Endo, Tomomi Aoi, Kazuki Hashimoto, Toru Nakazawa, Yuko Wada, Shinji Ueno, Dan Gao, Akira Murakami, Yoshihiro Hotta, Yasuhiro Ikeda, Koji M Nishiguchi, Yukihide Momozawa, Koh-Hei Sonoda, Masato Akiyama, Akihiro Fujimoto

Journal of medical genetics　59　(11)　1133-1138　2022/06/15

DOI： 10.1136/jmedgenet-2022-108428 　

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Despite the successful identification of causative genes and genetic variants of retinitis pigmentosa (RP), many patients have not been molecularly diagnosed. Our recent study using targeted short-read sequencing showed that the proportion of carriers of pathogenic variants in EYS, the cause of autosomal recessive RP, was unexpectedly high in Japanese patients with unsolved RP. This result suggested that causative genetic variants, which are difficult to detect by short-read sequencing, exist in such patients. Using long-read sequencing technology (Oxford Nanopore), we analysed the whole genomes of 15 patients with RP with one heterozygous pathogenic variant in EYS detected in our previous study along with structural variants (SVs) in EYS and another 88 RP-associated genes. Two large exon-overlapping deletions involving six exons were identified in EYS in two patients with unsolved RP. An analysis of an independent patient set (n=1189) suggested that these two deletions are not founder mutations. Our results suggest that searching for SVs by long-read sequencing in genetically unsolved cases benefits the molecular diagnosis of RP.
Follow-up of retinal thickness and optic MRI after optic neuritis in anti-MOG antibody-associated disease and anti-AQP4 antibody-positive NMOSD. International-journal

Tetsuya Akaishi, Noriko Himori, Takayuki Takeshita, Tatsuro Misu, Toshiyuki Takahashi, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Toru Nakazawa, Ichiro Nakashima

Journal of the neurological sciences　437　120269-120269　2022/06/15
Publisher: Elsevier BV
DOI： 10.1016/j.jns.2022.120269 　

ISSN： 0022-510X

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BACKGROUND: Retinal atrophy in the chronic phase of optic neuritis (ON) in anti-aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains unclear. METHODS: Patients with these diseases were repeatedly evaluated using optical coherence tomography (OCT) for the circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (mGCC) in the ON-involved eyes during relapse-free period after the first ON episode before relapse. Optic MRI with short tau inversion recovery (STIR) sequences was further evaluated retrospectively. RESULTS: Twelve patients with MOGAD (20 eyes with ON-involvement) and 14 with AQP4-Ab-positive NMOSD (16 eyes with ON-involvement) were enrolled. The progression of retinal atrophy ≥12 months after onset was observed in AQP4-Ab-positive NMOSD, but was not apparent in MOGAD. A decrease in retinal thickness by the same amount results in more severe visual impairment in AQP4-Ab-positive NMOSD. On optic MRI, the residual STIR hyperintensity in the optic nerves remained in the chronic phase in almost all eyes with ON in both diseases. Optic nerve atrophy occurred in all evaluated ON-involved eyes in AQP4-Ab-positive NMOSD, while it was observed in half of ON-involved eyes in MOGAD. CONCLUSIONS: Progression of retinal atrophy in the chronic phase has been observed in patients with AQP4-Ab-positive NMOSD, while it remains uncertain in patients with MOGAD. The visual impairments upon similar levels of retinal atrophy would be worse in AQP4-Ab-positive NMOSD, possibly attributable in part to a higher incidence of optic nerve atrophy in this disease.
Correlation Between Enlargement of Retinal Nerve Fiber Defect Angle in En Face Imaging and Visual Field Progression. International-journal

Naoki Takahashi, Kazuko Omodaka, Arata Nakazawa, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Noriko Himori, Masahiro Akiba, Toru Nakazawa

Translational vision science & technology　11　(6)　8-8　2022/06/01

DOI： 10.1167/tvst.11.6.8 　

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Purpose: Retinal nerve fiber layer defects (RNFLDs) become enlarged with glaucoma progression. We measured the RNFLD angle and investigated whether it was correlated with deterioration of the visual field in patients with glaucoma. Methods: This study included 84 eyes of 84 patients with open-angle glaucoma (mean deviation [MD] = -6.51 ± 5.91 dB, follow-up period = 2.82 ± 0.74 years) with the RNFLDs, who underwent en face swept-source optical coherence tomography (SS-OCT) wide scans (12 × 9 mm) at least 6 times. The RNFLD angle was measured as the intersection between the RNFLD and a circle centered on the disc with a radius half the distance between the disc and the fovea. Slopes for the RNFLD angle, macular ganglion cell layer thickness (GCCT), and circumpapillary RNFL thickness (cpRNFLT) were compared with the MD slope, as measured with the Humphrey field analyzer 24-2 program. Results: The correlation coefficients with MD slope were -0.67 for the RNFLD angle slope (P < 0.001), 0.15 for the macular GCCT slope (P = 0.163), and 0.04 for the cpRNFLT slope (P = 0.719). The RNFLD angle tended to increase as the number of disc hemorrhage occurrences increased (rs = 0.31, P = 0.004). The RNFLD angle slope also had good predictive power for glaucoma progression (area under the receiver operating characteristic curve = 0.88, 95% confidence interval = 0.81-0.95). Conclusions: We found that the RNFLD angle slope was more closely associated with the MD slope than were other OCT parameters. This suggests that measurement of the RNFLD angle with en face OCT images could be effective in evaluating glaucoma progression. Translational Relevance: Our study provides a method for monitoring glaucoma progression with SS-OCT.
Correction: Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis. International-journal

Hiroshi Komatsu, Goh Onoguchi, Stefan Jerotic, Nobuhisa Kanahara, Yoshihisa Kakuto, Takashi Ono, Shunichi Funakoshi, Takeshi Yabana, Toru Nakazawa, Hiroaki Tomita

Molecular psychiatry　27　(9)　3617-3618　2022/05/27

DOI： 10.1038/s41380-022-01620-9 　
A lightweight deep learning model for automatic segmentation and analysis of ophthalmic images. International-journal

Parmanand Sharma, Takahiro Ninomiya, Kazuko Omodaka, Naoki Takahashi, Takehiro Miya, Noriko Himori, Takayuki Okatani, Toru Nakazawa

Scientific reports　12　(1)　8508-8508　2022/05/20

DOI： 10.1038/s41598-022-12486-w 　

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Detection, diagnosis, and treatment of ophthalmic diseases depend on extraction of information (features and/or their dimensions) from the images. Deep learning (DL) model are crucial for the automation of it. Here, we report on the development of a lightweight DL model, which can precisely segment/detect the required features automatically. The model utilizes dimensionality reduction of image to extract important features, and channel contraction to allow only the required high-level features necessary for reconstruction of segmented feature image. Performance of present model in detection of glaucoma from optical coherence tomography angiography (OCTA) images of retina is high (area under the receiver-operator characteristic curve AUC ~ 0.81). Bland-Altman analysis gave exceptionally low bias (~ 0.00185), and high Pearson's correlation coefficient (p = 0.9969) between the parameters determined from manual and DL based segmentation. On the same dataset, bias is an order of magnitude higher (~ 0.0694, p = 0.8534) for commercial software. Present model is 10 times lighter than Unet (popular for biomedical image segmentation) and have a better segmentation accuracy and model training reproducibility (based on the analysis of 3670 OCTA images). High dice similarity coefficient (D) for variety of ophthalmic images suggested it's wider scope in precise segmentation of images even from other fields. Our concept of channel narrowing is not only important for the segmentation problems, but it can also reduce number of parameters significantly in object classification models. Enhanced disease diagnostic accuracy can be achieved for the resource limited devices (such as mobile phone, Nvidia's Jetson, Raspberry pi) used in self-monitoring, and tele-screening (memory size of trained model ~ 35 MB).
Comparing Surgical Outcomes in Neovascular Glaucoma between Tube and Trabeculectomy: A Multicenter Study. International-journal

Kentaro Iwasaki, Sachi Kojima, Ryotaro Wajima, Tomoyuki Okazaki, Yu Yokoyama, Toshihiro Inoue, Tomomi Higashide, Atsuya Miki, Toru Nakazawa, Masaru Inatani

Ophthalmology. Glaucoma　5　(6)　672-680　2022/05/20

DOI： 10.1016/j.ogla.2022.05.003 　

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OBJECTIVE: To compare the surgical outcomes between Baerveldt glaucoma implant (BGI) surgery and trabeculectomy with mitomycin C for patients with neovascular glaucoma (NVG). DESIGN: Retrospective clinical cohort study at five clinical centers in Japan. PARTICIPANTS: Patients treated with trabeculectomy or BGI for NVG between April 1, 2012, and December 31, 2019, at five clinical centers were recruited. METHODS: The inclusion criteria were age ≥20 years and having NVG. The exclusion criteria were eyes with no light perception vision and with previous tube-shunt surgery. If both eyes in the same patient satisfied the inclusion criteria, the eye that was treated first was investigated. We included 100 eyes undergoing BGI surgery and 204 eyes undergoing trabeculectomy. MAIN OUTCOME MEASURES: The primary outcome was surgical success or failure, with failure being defined according to three criteria: <20% reduction of the preoperative intraocular pressure (IOP) or criterion A (IOP >21 mmHg), criterion B (IOP >17 mmHg), or criterion C (IOP >14 mmHg). Cases of reoperation, a loss of light perception vision, or hypotony were also considered failures. RESULTS: The probability of success was significantly higher in patients undergoing BGI surgery than in those receiving trabeculectomy for criteria A (P < 0.01) and B (P = 0.01). Trabeculectomy was significantly associated with surgical failure in the multivariable analysis for criterion A (hazard ratio, 1.70) and criterion B (hazard ratio, 1.50). The overall incidence of postoperative complications was similar between the two groups. Reoperations for glaucoma were required significantly more frequently in the trabeculectomy group than in the BGI surgery group (20.1 % vs. 5.0%, P < 0.01). CONCLUSIONS: BGI surgery had a higher success rate as compared with trabeculectomy in patients with NVG for a target IOP of <21 mmHg or <17 mmHg. The rates of postoperative complications were similar between both surgical procedures. Additional glaucoma surgery was required more frequently after trabeculectomy than after BGI surgery.
Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis. International-journal

Hiroshi Komatsu, Goh Onoguchi, Stefan Jerotic, Nobuhisa Kanahara, Yoshihisa Kakuto, Takashi Ono, Shunichi Funakoshi, Takeshi Yabana, Toru Nakazawa, Hiroaki Tomita

Molecular psychiatry　27　(9)　3617-3618　2022/05/02

DOI： 10.1038/s41380-022-01591-x 　

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INTRODUCTION: The retina shares structural and functional similarities with the brain. Furthermore, structural changes in the retina have been observed in patients with schizophrenia spectrum disorders (SSDs). This systematic review and meta-analysis investigated retinal abnormalities and their association with clinical factors for SSD. METHODS: Studies related to retinal layers in SSD patients were retrieved from PubMed, Scopus, Web of Science, Cochrane Controlled Register of Trials, International Clinical Trials Registry Platform, and PSYNDEX databases from inception to March 31, 2021. We screened and assessed the eligibility of the identified studies. EZR ver.1.54 and the metafor package in R were used for the meta-analysis and a random-effects or fixed-effects model was used to report standardized mean differences (SMDs). RESULTS: Twenty-three studies (2079 eyes of patients and 1571 eyes of controls) were included in the systematic review and meta-analysis. The average peripapillary retinal nerve fiber layer (pRNFL) thickness, average macular thickness (MT), and macular ganglion cell layer-inner plexiform layer (GCL-IPL) thickness were significantly lower in patients than in controls (n = 14, 6, and 3, respectively; SMD = -0.33, -0.49, and -0.43, respectively). Patients also had significantly reduced macular volume (MV) compared to controls (n = 7; SMD = -0.53). The optic cup volume (OCV) was significantly larger in patients than in controls (n = 3; SMD = 0.28). The meta-regression analysis indicated an association between several clinical factors, such as duration of illness and the effect size of the pRNFL, macular GCL-IPL, MT, and MV. CONCLUSION: Thinning of the pRNFL, macular GCL-IPL, MT, and MV and enlargement of the OCV in SSD were observed. Retinal abnormalities may be applicable as state/trait markers in SSDs. The accumulated evidence was mainly cross-sectional and requires verification by longitudinal studies to characterize the relationship between OCT findings and clinical factors.
A case of retinal vasoproliferative tumor removed by pars plana vitrectomy

新田文彦, 國方彦志, 古田実, 阿部俊明, 中澤徹

臨床眼科　76　(5)　677-683　2022/05
Publisher:
ISSN： 0370-5579

eISSN： 1882-1308
Infrared slit light-based scanning type portable device for monitoring of cataract

Neelam Kaushik, Takashi Sasaki, Hiroyuki Kamijo, Toru Nakazawa, Kazuhiro Hane

Optical Engineering　61　(3)　2022/03/01

DOI： 10.1117/1.OE.61.3.035103 　

ISSN： 0091-3286

eISSN： 1560-2303
Interim Results of Post-Marketing Observational Study of Omidenepag Isopropyl for Glaucoma and Ocular Hypertension in Japan. International-journal

Toru Nakazawa, Kanji Takahashi, Yasuaki Kuwayama, Akio Nomura, Fumiki Shimada

Advances in therapy　39　(3)　1359-1374　2022/03

DOI： 10.1007/s12325-021-02035-8 　

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INTRODUCTION: This post-marketing observational interim analysis evaluated the 12-month effectiveness and safety of omidenepag isopropyl (OMDI) ophthalmic solution in daily clinical settings. METHODS: This was a multicenter, large-scale, non-interventional, prospective, observational study conducted in Japan. The target enrollment was 3900 patients, and the overall observation period was 12 months. Patients with glaucoma and ocular hypertension (OH) with no previous history of OMDI use were enrolled. The key endpoints were change in intraocular pressure (IOP) from baseline and the incidence of adverse reactions (ADRs). RESULTS: A total of 1862 patients were evaluated in this 12-month interim analysis. Most patients were diagnosed with normal-tension glaucoma (NTG, 62.0%). The treatment patterns with OMDI were naïve monotherapy (48.4%), switching monotherapy (18.4%), and concomitant therapy (31.1%). The overall incidence of ADRs was 24.3%, which was similar between the monotherapy and concomitant therapy groups. Common ADRs were conjunctival hyperemia, refractive disorder, and myopia. Macular edema was observed in four patients. No ADRs categorized as prostaglandin-associated periorbitopathy were observed. There was a significant reduction in mean IOP at 12 months, with a change of - 1.9 ± 2.9 mmHg from baseline (reduction - 10.4 ± 16.5%). The mean IOP change from baseline was - 2.7 ± 2.6 mmHg in the naïve monotherapy group, - 1.1 ± 2.6 mmHg in the switching monotherapy group, and - 1.6 ± 3.1 mmHg in the concomitant therapy group (all P < 0.05). The mean IOP decreased by - 2.5 ± 3.2 mmHg, - 1.5 ± 2.4 mmHg, and - 2.3 ± 4.5 mmHg in the primary open-angle glaucoma (POAG), NTG, and OH groups, respectively. The treatment persistence with OMDI was 82.4%. CONCLUSION: This study demonstrated the safety and efficacy of OMDI for glaucoma and OH as monotherapy and concomitant therapy in daily clinical settings. In this interim analysis, OMDI showed a favorable benefit-risk profile, and can be first-line therapy for glaucoma.
Acute Primary Angle Closure Caused by Plateau Iris After Ritodrine Use in a Primigravid Woman Successfully Treated With Clear-Lens Extraction: A Case Report. International-journal

Sayaka Yoshida, Masaaki Yoshida, Noriko Himori, Shiho Kunimatsu-Sanuki, Toru Nakazawa

Cureus　14　(2)　e22036　2022/02

DOI： 10.7759/cureus.22036 　

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Acute primary angle closure (APAC) is rare in young adults (those under approximately 40 years old) and pregnant women. Here, we report the case of a 37-year-old primigravid woman with APAC caused by plateau iris after the use of ritodrine (a β2 stimulator) that was successfully resolved by clear-lens extraction five months after delivery. The patient presented with pain in her right eye after ritodrine infusion for threatened premature labor at 23 weeks of gestation. Her visual acuity was 20/40, and her intraocular pressure (IOP) was 31 mmHg in her right eye. The patient was diagnosed as having APAC with plateau iris based on ultrasound biomicroscopy (UBM) findings of irido-angle touch, anterior dislocation of the ciliary process, and an absent ciliary sulcus. The effectiveness of treatment with pilocarpine eyedrops was limited, and argon laser peripheral iridoplasty did not succeed in reducing IOP. An immediate resolution was achieved with clear-lens extraction. IOP has since stayed within 14-16 mmHg without any medication for seven years. This is the first reported case of APAC complicated with plateau iris after ritodrine use in a pregnant woman. This condition is rare in young adults, making it difficult to diagnose; however, UBM can be of great help. In this case, clear-lens extraction led to a successful outcome. Our case suggests that attention should be paid to drug associations when APAC occurs with plateau iris.
Noninferiority of Microhook to Trabectome: Trabectome versus Ab Interno Microhook Trabeculotomy Comparative Study (Tram Trac Study). International-journal

Sotaro Mori, Masaki Tanito, Nobuyuki Shoji, Yu Yokoyama, Takanori Kameda, Takuhei Shoji, Shiro Mizoue, Yuta Saito, Kyoko Ishida, Toshihiko Ueda, Makoto Nakamura, Koji Namiguchi, Shiro Mizoue, Kyoko Ishida, Kenji Inoue, Yusuke Kono, Masayuki Kasahara, Nobuyuki Shoji, Sotaro Mori, Matsumiya Wataru, Nagai Takayuki, Makoto Nakamura, Takanori Kameda, Akagi Tadamichi, Toshihiko Ueda, Jun Makita, Takuhei Shoji, Michihiro Kono, Masaki Tanito, Kota Yokoyama, Yuta Saito, Kyoko Ishida, Yu Yokoyama, Toru Nakazawa

Ophthalmology. Glaucoma　5　(4)　452-461　2022

DOI： 10.1016/j.ogla.2021.11.005 　

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PURPOSE: To elucidate the noninferiority of ab interno microhook trabeculotomy (μTLO) using a recently developed reusable stainless spatula-type microhook device to incise the trabecular meshwork to Trabectome (Neomeix, Inc) surgery in terms of the 1-year postoperative outcomes of Japanese patients with glaucoma by means of propensity score analyses. DESIGN: Multicenter, retrospective cohort study. PARTICIPANTS: We enrolled 553 and 392 patients who underwent Trabectome surgery and μTLO, respectively, between January 2014 and March 2020 at 10 facilities. METHODS: Logistic regression analysis was conducted to calculate the propensity score, which indicates the likelihood of treatment assignment (Trabectome or μTLO). We set the following factors as outcome-related covariates: age, sex, facility, glaucoma disease types, preoperative intraocular pressure (IOP), glaucoma drug score, mean deviation of Humphrey visual field test results, antithrombotic drug use, the presence or absence of combined cataract surgery, and incision range of the trabecular meshwork (1 or 2 quadrants). We analyzed 4 different methods (matching, inverse probability of treatment weighting [IPTW], stratification, and regression adjustment) using the propensity score. We set 15% as the noninferiority margin based on previous Trabectome meta-analysis results. MAIN OUTCOME MEASURES: The primary outcome was surgical success at 1 year after surgery. We defined surgical success as satisfying all 3 criteria: (1) IOP within 5 to 21 mmHg, (2) IOP reduction of 20% or more from preoperative IOP, and (3) no additional glaucoma surgery. RESULTS: The 95% confidence interval of risk difference of surgical failure in μTLO in reference to Trabectome surgery was -12.1% to +9.5% in matching, -12.7% to +11.1% in IPTW, -12.2 to +7.0 in stratification, and -9.7% to +8.1% in regression adjustment, all of which fell within the predetermined noninferiority margin of 15%. CONCLUSIONS: Surgical success of μTLO at 1 year after was not inferior to that of Trabectome surgery.
Surgical outcome and pathological findings in macular epiretinal membrane caused by neurofibromatosis type 2. International-journal

Hiroshi Kunikata, Koji M Nishiguchi, Mika Watanabe, Toru Nakazawa

Digital journal of ophthalmology : DJO　28　(1)　12-16　2022

DOI： 10.5693/djo.02.2021.06.001 　

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We present surgical outcomes in a 10-year-old Japanese girl with neurofibromatosis type 2 (NF2)-induced epiretinal membrane (ERM). Her right eye underwent lens-sparing 27-gauge microincision vitrectomy surgery (MIVS) with ERM peeling. Decimal best-corrected visual acuity increased from 0.3 to 0.4 postoperatively. However, abnormal thickening of the macula persisted for 3 years. Staining of the extracted ERM revealed many cells positive for glial fibrillary acidic protein and nestin. Although removal of NF2-induced ERM with MIVS can improve visual acuity, the potential surgical risks require careful consideration on a case-by-case basis.
The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy. International-journal

Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F Covey, Charles F Zorumski, Yukitoshi Izumi

Frontiers in pharmacology　13　855779-855779　2022

DOI： 10.3389/fphar.2022.855779 　

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In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy. We now examine whether its enantiomer (ent-AlloP), which is largely inactive at GABA receptors, offers similar neuroprotection in ex vivo and in vivo rat OHT models. Ex vivo rat retinal preparations were incubated in a hyperbaric condition (10 and 75 mmHg) for 24 h. An in vivo ocular hypertension (OHT) model was induced by intracameral injection of polystyrene microbeads. We examined pharmacological effects of AlloP, ent-AlloP, picrotoxin (a GABAA receptor antagonist), and 3-MA (an autophagy inhibitor) histologically and biochemically. We found that both AlloP and ent-AlloP have marked neuroprotective effects in the retina, but effects of the unnatural enantiomer are independent of GABAA receptors. Electron microscopic analyses show that pressure elevation significantly increased autophagosomes (APs) in the nerve fiber layer and addition of AlloP also increased APs and degenerative autophagic vacuoles (AVds). ent-AlloP markedly increased APs and AVds compared to AlloP. Examination of LC3B-II and SQSTM1 protein levels using immunoblotting revealed that AlloP increased LC3B-II, and ent-AlloP further enhanced LC3B-II and suppressed SQSTM1, indicating that autophagy is a major mechanism underlying neuroprotection by ent-AlloP. In an rat in vivo OHT model, single intravitreal ent-AlloP injection prevented apoptotic cell death of retinal ganglion cells similar to AlloP. However, even in this model, ent-AlloP was more effective in activating autophagy than AlloP. We conclude that ent-AlloP may be a prototype of potential therapeutic for treatment of glaucoma as an autophagy enhancer without affecting GABA receptors.
A Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice. International-journal

Shigeto Maekawa, Kota Sato, Taiki Kokubun, Noriko Himori, Takeshi Yabana, Michiko Ohno-Oishi, Ge Shi, Kazuko Omodaka, Toru Nakazawa

Clinical ophthalmology (Auckland, N.Z.)　16　823-832　2022

DOI： 10.2147/OPTH.S354958 　

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Purpose: To investigate the effect of plant-derived antioxidant compounds, identified with primary culture screening, on retinal ganglion cell (RGC) survival in mice under excitotoxic conditions. Additionally, to determine the effect of these compounds on the involvement of calpain inactivation. Materials and Methods: Plant-derived antioxidant compounds including hesperidin, crocetin, and Tamarindus indica were administrated orally to C57BL/6J mice. The levels of lipid oxidation and calpain activation were assessed with a TBARS assay and western blotting. RGC survival was evaluated with a TUNEL assay and RBPMS immunostaining after intravitreal injection of NMDA. Results: Plant-derived antioxidant compounds significantly ameliorated the increase in the level of MDA in the retinas after NMDA injury. Cleaved α-fodrin fragments were detected in the NMDA-injured retinas, and these fragments were significantly lower in mice that received the plant-derived antioxidant compounds. The plant-derived antioxidants also ameliorated increases in TUNEL-positive cells and RGC death after NMDA injection. Conclusion: These results indicate that oral administration of plant-derived antioxidant compounds such as hesperidin, crocetin, and Tamarindus indica suppressed RGC death. This oral supplementation decreased lipid oxidation and excessive calpain activation in NMDA-injured retinas. Thus, our newly developed antioxidant supplement has a potential role in neuroprotective treatment for retinal diseases, such as glaucoma.
CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice. International-journal

Kota Sato, Taimu Sato, Michiko Ohno-Oishi, Mikako Ozawa, Shigeto Maekawa, Yukihiro Shiga, Takeshi Yabana, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Kosuke Fujita, Koji M Nishiguchi, Shi Ge, Toru Nakazawa

Experimental eye research　213　108826-108826　2021/12

DOI： 10.1016/j.exer.2021.108826 　

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Glaucoma is a leading cause of blindness worldwide and is characterized by degeneration associated with the death of retinal ganglion cells (RGCs). It is believed that glaucoma is a group of heterogeneous diseases with multifactorial pathomechanisms. Here, we investigate whether anti-inflammation treatment with an ER stress blockade can selectively promote neuroprotection against NMDA injury in the RGCs. Retinal excitotoxicity was induced with an intravitreal NMDA injection. Microglial activation and neuroinflammation were evaluated with Iba1 immunostaining and cytokine gene expression. A stable HT22 cell line transfected with an NF-kB reporter was used to assess NF-kB activity after hesperidin treatment. CHOP-deficient mice were used as a model of ER stress blockade. Retinal cell death was evaluated with a TUNEL assay. As results, in the NMDA injury group, Iba1-positive microglia increased 6 h after NMDA injection. Also at 6 h, pro-inflammatory cytokines and chemokine increased, including TNFα, IL-1b, IL-6 and MCP-1. In addition, the MCP-1 promoter-driven EGFP signal, which we previously identified as a stress signal in injured RGCs, also increased; hesperidin treatment suppressed this inflammatory response and reduced stressed RGCs. In CHOP-deficient mice that received an NMDA injection, the gene expression of pro-inflammatory cytokines, chemokines, markers of active microglia, and inflammatory regulators was greater than in WT mice. In WT mice, hesperidin treatment partially prevented retinal cell death after NMDA injury; this neuroprotective effect was enhanced in CHOP-deficient mice. These findings demonstrate that ER stress blockade is not enough by itself to prevent RGC loss due to neuroinflammation in the retina, but it has a synergistic neuroprotective effect after NMDA injury when combined with an anti-inflammatory treatment based on hesperidin.
Ripasudil eyedrops ameliorated bullous keratopathy complicated with cytomegalovirus corneal endotheliitis: a case report. International-journal

Masaaki Yoshida, Shunji Yokokura, Takehiro Hariya, Wataru Kobayashi, Kazuki Hashimoto, Toru Nakazawa

Ocular immunology and inflammation　1-4　2021/11/02

DOI： 10.1080/09273948.2021.1988114 　

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PURPOSE: We describe a case of bullous keratopathy complicated with cytomegalovirus (CMV) corneal endotheliitis that was successfully treated with ripasudil eye drops. METHODS: A retrospective case report. RESULTS: A 65-year-old female patient diagnosed with CMV-associated anterior uveitis in the right eye was referred to us when anterior uveitis recurred with bullous keratopathy. Initial best-corrected visual acuity (BCVA) was 0.4 (decimal visual acuity). Her condition did not improve with anti-CMV treatment, and BCVA decreased to 0.07. At this point, intraocular pressure (IOP) was 20 mmHg, and ripasudil eye drops were started for IOP control. After 1 month, not only had IOP decreased to 14 mm Hg but the condition of the corneal edema had also improved. The central corneal thickness decreased to a normal level, and the BCVA recovered to 0.8. CONCLUSION: Ripasudil eye drops not only lower IOP in patients with CMV corneal endotheliitis but may also have the potential to treat bullous keratopathy.
Association between Topographic Features of the Retinal Nerve Fiber Bundle and Good Visual Acuity in Patients with Glaucoma. International-journal

Naoki Takahashi, Kazuko Omodaka, Tsutomu Kikawa, Masahiro Akiba, Toru Nakazawa

Current eye research　46　(11)　1724-1731　2021/11

DOI： 10.1080/02713683.2021.1912782 　

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Purpose: Maintaining visual acuity in glaucoma patients is an important part of preventing the deterioration of quality of vision. We identified specific areas of the papillomacular bundle (PMB) that were strongly associated with visual acuity, based on en-face images derived from optical coherence topography (OCT) wide scans.Methods: The study recruited 23 eyes of 21 glaucoma patients (age: 61.3 ± 13.0 years, M: F = 9:12, Humphrey field analyzer-measured mean deviation: -19.9 ± 6.5 dB) with good best-corrected visual acuity (20/20 or more) and a remaining PMB with a maximum width no more than half that of the vertical disc diameter. En-face images were derived from 12 × 9 mm wide-scan images made with DRI-OCT (Triton, Topcon). Averaged en-face images were created by identifying the disc center and fovea line (DFL) and aligning it between images. We then measured the frequency of remaining PMB at 10 µm intervals along a vertical line intersecting the DFL at its midpoint. Finally, we used a logistic analysis in a much larger group of patients to identify cases of glaucoma with low BCVA (<20/20).Results: In the averaged en-face image, the residual PMB area appeared as a high-intensity region above the DFL. Analysis showed that residual PMB was most common in an area 830-870 µm above the DFL. The correlation coefficient of residual PMB in this area to BCVA was -0.57 (p < .01), and among OCT parameters in this residual PMB area, the AUC to identify decreased BCVA was highest for ganglion cell complex thickness (0.85, p < .01), with a cutoff of 87.5 µm.Conclusions: This study identified specific areas of the PMB that were associated with BCVA in wide-scan, en-face OCT images from glaucoma patients. This suggests that it may be possible to identify visual impairment during glaucoma treatment by measuring this area.
Polypoidal choroidal vasculopathy in a case of retinitis pigmentosa, successfully treated with intravitreal aflibercept. International-journal

Nana Takahashi, Hiroshi Kunikata, Masayuki Yasuda, Takehiro Hariya, Koji M Nishiguchi, Toru Nakazawa

American journal of ophthalmology case reports　23　101123-101123　2021/09

DOI： 10.1016/j.ajoc.2021.101123 　

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Purpose: Polypoidal choroidal vasculopathy (PCV) is a subtype of age-related macular degeneration that is seen frequently in Asians. Nevertheless, it is rare for this condition to be combined with retinitis pigmentosa (RP). The purpose of this paper is to present findings from this rare combination in a Japanese patient, and to describe its successful treatment with intravitreal aflibercept (IVA). Observations: The patient was a 71-year-old Japanese woman with RP (diagnosed at the age of 30) and PCV. She noticed a decrease in vision in her right eye 6 months previously. Decimal best-corrected visual acuity (BCVA) was 0.05 in her right eye. Optical coherence tomography and indocyanine green angiography (IA) revealed serous retinal detachment (SRD) and PCV in her right eye. The SRD was initially resolved after 3 monthly treatments with IVA, but recurrences began 5 months later, requiring four more treatments with IVA, performed about every 4 months within the next 12 months, for successful resolution. There were no recurrences of PCV in 7 more months of follow-up, as confirmed with IA at the final appointment. Final decimal BCVA in the right eye improved to 0.15. Furthermore, macular retinal sensitivity, measured with microperimetry, increased after the treatment, and RP-related visual field narrowing, determined by Goldmann perimetry, did not progress throughout follow up of 26 months. Conclusion: More than 2 years of follow up showed that IVA may be effective for treating PCV, even in RP patients, and can increase central visual function without causing progression of RP-related visual field narrowing.
Five-year visual outcomes after optic neuritis in anti-MOG antibody-associated disease. International-journal

Tetsuya Akaishi, Noriko Himori, Takayuki Takeshita, Tatsuro Misu, Toshiyuki Takahashi, Yoshiki Takai, Shuhei Nishiyama, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Toru Nakazawa, Ichiro Nakashima

Multiple sclerosis and related disorders　56　103222-103222　2021/08/24

DOI： 10.1016/j.msard.2021.103222 　

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INTRODUCTION: Optic neuritis (ON) is a major phenotype of clinical attack related to demyelinating neurological diseases of the central nervous system, including multiple sclerosis (MS), anti-aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD), and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). As the concept of MOGAD is relatively new, the long-term visual outcomes after ON in MOGAD remains unclear. METHODS: To elucidate the long-term visual prognosis after ON in MOGAD, patients with MOGAD whose visual acuity were regularly followed for more than 5 years from the onset of ON were enrolled. Best-corrected visual acuity (BCVA) at nadir in the acute phase and at 1 and 5 years from onset was evaluated. The data from patients with MOGAD were compared with those from patients with MS or anti-AQP4-positive NMOSD. RESULTS: Twenty-three patients (31 ON-involved eyes) with MOGAD, 20 patients (24 ON-involved eyes) with MS, and 22 patients (24 ON-involved eyes) with anti-AQP4-positive NMOSD were evaluated. All BCVA at nadir, 1 year, and 5 years from the onset of ON were much worse in anti-AQP4-positive NMOSD than in MS (p = 0.0024) and MOGAD (p = 0.0014) patients. In MOGAD and anti-AQP4-positive NMOSD, the serum disease-specific antibody titer was not associated with the subsequent visual prognosis. Visual acuity had almost fully recovered spontaneously or shortly after initiating acute treatment in 22 of the 23 patients with MOGAD-ON. The administration of high-dose intravenous steroid therapy further facilitated early recovery of visual acuity. Meanwhile, a small fraction of patients with extensive optic nerve lesions involving the chiasma irreversibly experienced severe visual impairment despite appropriate acute treatment. CONCLUSION: Although a small fraction of patients with MOGAD who presented with extensive optic nerve lesions experienced irreversible severe visual impairment, the long-term visual outcomes after 5 years from ON in patients with MOGAD were generally as good as that in patients with MS and much better than that in patients with anti-AQP4-positive NMOSD.
Efficacy of early microincision vitrectomy surgery in traumatic macular hole. International-journal

Hiroshi Kunikata, Urara Osada, Toshiaki Abe, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　259　(8)　2451-2454　2021/08

DOI： 10.1007/s00417-021-05139-7 　
Optic neuritis after ocular trauma in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. International-journal

Tetsuya Akaishi, Noriko Himori, Takayuki Takeshita, Kazuo Fujihara, Tatsuro Misu, Toshiyuki Takahashi, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Toru Nakazawa, Ichiro Nakashima

Brain and behavior　11　(5)　e02083　2021/05

DOI： 10.1002/brb3.2083 　

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OBJECTIVE: The aim of this study was to report the possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti-aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). METHODS: Herein, we present three patients who developed acute optic neuritis with visual disturbances after accidental minor trauma to their eyes, without any fundus abnormality or orbital floor fractures present. RESULTS: Two of the three patients had a preceding history of neurological disturbances compatible with NMOSD (e.g., myelitis, area postrema syndrome) before the occurrence of trauma. One patient was rapidly treated with steroid pulse therapy and plasmapheresis, and he fully recovered visual acuity. The other two, who were left untreated in the acute phase, had sequelae of severe visual disturbances in the affected eyes. CONCLUSIONS: These cases suggest possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti-AQP4 antibodies. Avoiding ocular trauma and early administration of steroid pulse therapy in response to optic neuritis after trauma are desired in such cases.
Regional differences in genes and variants causing retinitis pigmentosa in Japan.

Yoshito Koyanagi, Masato Akiyama, Koji M Nishiguchi, Yukihide Momozawa, Yoichiro Kamatani, Sadaaki Takata, Chihiro Inai, Yusuke Iwasaki, Mikako Kumano, Yusuke Murakami, Shiori Komori, Dan Gao, Kentaro Kurata, Katsuhiro Hosono, Shinji Ueno, Yoshihiro Hotta, Akira Murakami, Hiroko Terasaki, Yuko Wada, Toru Nakazawa, Tatsuro Ishibashi, Yasuhiro Ikeda, Michiaki Kubo, Koh-Hei Sonoda

Japanese journal of ophthalmology　65　(3)　338-343　2021/05

DOI： 10.1007/s10384-021-00824-w 　

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PURPOSE: To investigate the regional differences in the genes and variants causing retinitis pigmentosa (RP) in Japan STUDY DESIGN: Retrospective multicenter study METHODS: In total, 1204 probands of each pedigree clinically diagnosed with nonsyndromic RP were enrolled from 5 Japanese facilities. The regions were divided into the Tohoku region, the Kanto and Chubu regions, and the Kyushu region according to the location of the hospitals where the participants were enrolled. We compared the proportions of the causative genes and the distributions of the pathogenic variants among these 3 regions. RESULTS: The proportions of genetically solved cases were 29.4% in the Tohoku region (n = 500), 29.6% in the Kanto and Chubu regions (n = 196), and 29.7% in the Kyushu region (n = 508), which did not differ statistically (P = .99). No significant regional differences in the proportions of each causative gene in genetically solved patients were observed after correction by multiple testing. Among the 29 pathogenic variants detected in all 3 regions, only p.(Pro347Leu) in RHO was an autosomal dominant variant; the remaining 28 variants were found in autosomal recessive genes. Conversely, 78.6% (275/350) of the pathogenic variants were detected only in a single region, and 6 pathogenic variants (p.[Asn3062fs] in EYS, p.[Ala315fs] in EYS, p.[Arg872fs] in RP1, p.[Ala126Val] in RDH12, p.[Arg41Trp] in CRX, and p.[Gly381fs] in PRPF31) were frequently found in ≥ 4 patients in the single region. CONCLUSION: We observed region-specific pathogenic variants in the Japanese population. Further investigations of causative genes in multiple regions in Japan will contribute to the expansion of the catalog of genetic variants causing RP.
Time-Course Changes in Optic Nerve Head Blood Flow and Retinal Nerve Fiber Layer Thickness in Eyes with Open-angle Glaucoma. International-journal

Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka, Kyongsun Pak, Toru Nakazawa

Ophthalmology　128　(5)　663-671　2021/05

DOI： 10.1016/j.ophtha.2020.10.010 　

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PURPOSE: To determine whether decreased optic nerve head (ONH) blood flow (BF) precedes or follows decreased circumpapillary retinal nerve fiber layer thickness (cpRNFLT) in eyes with open-angle glaucoma (OAG). DESIGN: Retrospective, longitudinal study. PARTICIPANTS: This study followed up 350 eyes of 225 OAG patients for at least 2 years and collected data from each patient from at least 5 examinations obtained with laser speckle flowgraphy (LSFG) and OCT. METHODS: In the superior, temporal, and inferior ONH quadrants, tissue area mean blur rate (MT), representing ONH tissue BF, was measured with LSFG, whereas cpRNFLT was measured with OCT. A multivariate linear mixed-effects model was used to identify potential predictors of faster MT decrease, adjusting for possible confounding factors. Based on these results, each quadrant of each patient was assigned a risk point if the quadrant was the superior or temporal, if patient age was older than the median (61 years), and if patient pulse rate was higher than median (74 beats per minute). The quadrants were then compared with a mixed-effects Cox model for MT and cpRNFLT changes, defined as a difference between the baseline value and the values from the latest 2 consecutive follow-up visits of more than 1.96 × the corresponding coefficient of variation. MAIN OUTCOME MEASURES: Ophthalmic and systemic variables and MT and cpRNFLT in the superior, temporal, and inferior quadrants. RESULTS: The multivariate model showed that MT decrease was faster in older patients with higher pulse rate and slower in inferior quadrants (P < 0.05). Quadrants with 0 risk points showed primary cpRNFLT decrease (P = 0.048), 1-risk point quadrants showed simultaneous cpRNFLT and MT decrease (P = 0.260), and 2-risk point and 3-risk point quadrants showed primary MT decrease (P < 0.001). CONCLUSIONS: Older patients with higher pulse rate are at greater risk of a primary reduction in ONH tissue BF, that is, preceding cpRNFLT decrease, in the superior and temporal quadrants.
Usefulness of Polarization-sensitive Optical Coherence Tomography-derived Attenuation-coefficient Images to Visualize the Internal Structure of the Filtering Bleb. International-journal

Mayo Kosugi, Taiki Kokubun, Satoru Tsuda, Masahiro Yamanari, Toru Nakazawa

Current eye research　46　(4)　606-609　2021/04

DOI： 10.1080/02713683.2020.1825749 　

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PURPOSE/AIM OF THE STUDY: Polarization-sensitive anterior-segmental optical coherence tomography (PS-OCT) is useful to evaluate the filtering blebs after trabeculectomy. However, the attenuation phenomenon of OCT signal disturbs the visibility of intra-bleb's structure and distribution of birefringence; a specific parameter of PS-OCT. This study aimed to evaluate the effectiveness of the attenuation-coefficient image of the filtering blebs. MATERIALS AND METHODS: This study included 25 eyes 6 months after TLE. The attenuation-coefficient image of blebs was calculated from OCT intensity signal information. The contrast level of the image (reflectivity of bleb's surface wall/reflectivity of scleral flap) in both attenuation-coefficient image and intensity image and the height of the bleb's wall were calculated. The improvement extent of contrast was defined as the ratio of contrast (attenuation-coefficient image's contrast/intensity image's contrast). We compared the contrast of attenuation-coefficient image and intensity image and investigated the relationship between improvement extent of contrast and height of bleb's wall. RESULTS: The contrast of the attenuation-coefficient image (317.7 ± 255.4%) was significantly higher than that of the intensity image (39.1 ± 24.5%) (P < .01) and the improvement extent of contrast was 9.5 ± 4.6 times. Furthermore, there was a positive correlation between the improvement extent of contrast and the height of the bleb's wall (r = 0.44, P = .03). CONCLUSIONS: The contrast of the image at depth of filtering blebs was improved by attenuation-coefficient image. It is suggested that the attenuation-coefficient image may improve the visibility of the structure and distribution of birefringence in the blebs compared to the intensity image.
Risk factors leading to trabeculectomy surgery of glaucoma patient using Japanese nationwide administrative claims data: a retrospective non-interventional cohort study. International-journal

Chikako Shirai, Satoru Tsuda, Kunio Tarasawa, Kiyohide Fushimi, Kenji Fujimori, Toru Nakazawa

BMC ophthalmology　21　(1)　153-153　2021/03/29

DOI： 10.1186/s12886-021-01897-4 　

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BACKGROUND: Early recognition and management of baseline risk factors may play an important role in reducing glaucoma surgery burdens. However, no studies have investigated them using real-world data in Japan or other countries. This study aimed to clarify the risk factors leading to trabeculectomy surgery, which is the most common procedure of glaucoma surgery, of glaucoma patient using the Japanese nationwide administrative claims data associated with the diagnosis procedure combination (DPC) system. METHODS: It was a retrospective, non-interventional cohort study. Data were collected from patients who were admitted to DPC participating hospitals, nationwide acute care hospitals and were diagnosed with glaucoma between 2012 to 2018. The primary outcome was the risk factors associated with trabeculectomy surgery. The association between baseline characteristics and trabeculectomy surgery was identified using multivariable logistic regression analysis by comparing patients with and without trabeculectomy surgery. Meanwhile, the secondary outcomes included the rate of comorbidities, the rate of concomitant drug use and the treatment patterns of glaucoma eye drops at the index admission. Among patients with trabeculectomy surgery, the risk factors leading to cataract surgery were also evaluated as subgroup analysis. RESULTS: A total of 29,599 patients included in the analysis, 12,038 and 17,561 patients were in the glaucoma surgery and non-glaucoma surgery cohorts, respectively. The factors associated with the increase in trabeculectomy surgery were having allergies, taking concomitant drugs including cancer, depression, ischemic heart disease and peptic ulcer, being diagnosed with primary open-angle glaucoma and longer length of stay in hospital. In contrast, the factors associated with the decrease in trabeculectomy surgery were having hypertension, taking hypertension drug, age ≥ 80 and female. CONCLUSIONS: Special focus on Japanese patients with glaucoma who have allergy-related comorbidities or take immune, nervous, circulatory or gastrointestinal system-related concomitant drugs seems to be desirable.
Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation. International-journal

Nobuko Enomoto, Ayako Anraku, Goji Tomita, Aiko Iwase, Takashi Sato, Nobuyuki Shoji, Tomoaki Shiba, Toru Nakazawa, Kazuhisa Sugiyama, Koji Nitta, Makoto Araie

Scientific reports　11　(1)　6847-6847　2021/03/25

DOI： 10.1038/s41598-021-86280-5 　

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To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and MV, respectively), and MT and MV pulse waveform parameters were obtained using LSFG and ONH structural parameters using planimetry. Multivariate linear mixed-effects modeled regression analysis identified factors contributing to MT- or MV-waveforms using age, gender, smoking history, body mass index, systolic and diastolic blood pressure, heart rate, intraocular pressure, axial length, disc, rim, and β-peripapillary atrophy areas, MT or MV, central retinal artery, and vein equivalents (CRAE and CRVE) as explanatory variables. MT- and MV-waveforms significantly correlated with one or more systemic factors, consistent with previous studies. Following confounding factor adjustment, MT-Skew significantly negatively correlated with β-PPA area (P = 0.026); MT- and MV-flow acceleration index positively correlated with CRAE, MT, and MV (P = 0.041-< 0.001), compatible with these parameters' observed correlations to systemic factors. Significantly negative correlations of the blowout score and acceleration time index to CRAE partly conflicted with their correlations to systemic factors, and other waveform parameters showed little correlation to ocular factors. Thus, Skew and flow acceleration index assisted the in vivo ocular circulation characterization.
Hierarchical deep learning models using transfer learning for disease detection and classification based on small number of medical images. International-journal

Guangzhou An, Masahiro Akiba, Kazuko Omodaka, Toru Nakazawa, Hideo Yokota

Scientific reports　11　(1)　4250-4250　2021/03/01

DOI： 10.1038/s41598-021-83503-7 　

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Deep learning is being employed in disease detection and classification based on medical images for clinical decision making. It typically requires large amounts of labelled data; however, the sample size of such medical image datasets is generally small. This study proposes a novel training framework for building deep learning models of disease detection and classification with small datasets. Our approach is based on a hierarchical classification method where the healthy/disease information from the first model is effectively utilized to build subsequent models for classifying the disease into its sub-types via a transfer learning method. To improve accuracy, multiple input datasets were used, and a stacking ensembled method was employed for final classification. To demonstrate the method's performance, a labelled dataset extracted from volumetric ophthalmic optical coherence tomography data for 156 healthy and 798 glaucoma eyes was used, in which glaucoma eyes were further labelled into four sub-types. The average weighted accuracy and Cohen's kappa for three randomized test datasets were 0.839 and 0.809, respectively. Our approach outperformed the flat classification method by 9.7% using smaller training datasets. The results suggest that the framework can perform accurate classification with a small number of medical images.
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. International-journal

Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W Hewitt, Ayellet V Segrè, John M Rouhana, Andrew R Hamel, Robert P Igo Jr, Helene Choquet, Ayub Qassim, Navya S Josyula, Jessica N Cooke Bailey, Pieter W M Bonnemaijer, Adriana Iglesias, Owen M Siggs, Terri L Young, Veronique Vitart, Alberta A H J Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B Melles, K Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K Lupton, Nicholas G Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J Foster, Peng T Khaw, James E Morgan, Nicholas G Strouthidis, Peter Kraft, Jae H Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L Haines, Chris Hammond, Louis R Pasquale, Caroline C W Klaver, Michael Hauser, Chiea Chuen Khor, David A Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E Craig, Stuart MacGregor, Janey L Wiggs

Nature communications　12　(1)　1258-1258　2021/02/24

DOI： 10.1038/s41467-020-20851-4 　

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Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects across European, Asian and African ancestries. Cross-ancestry data improve fine-mapping of causal variants for several loci. Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential contributions of several genes to POAG pathogenesis, including SVEP1, RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6. Several drug compounds targeting POAG risk genes may be potential glaucoma therapeutic candidates.
A hypomorphic variant in EYS detected by genome-wide association study contributes toward retinitis pigmentosa. International-journal

Koji M Nishiguchi, Fuyuki Miya, Yuka Mori, Kosuke Fujita, Masato Akiyama, Takashi Kamatani, Yoshito Koyanagi, Kota Sato, Toru Takigawa, Shinji Ueno, Misato Tsugita, Hiroshi Kunikata, Katarina Cisarova, Jo Nishino, Akira Murakami, Toshiaki Abe, Yukihide Momozawa, Hiroko Terasaki, Yuko Wada, Koh-Hei Sonoda, Carlo Rivolta, Tatsuhiko Tsunoda, Motokazu Tsujikawa, Yasuhiro Ikeda, Toru Nakazawa

Communications biology　4　(1)　140-140　2021/01/29

DOI： 10.1038/s42003-021-01662-9 　

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The genetic basis of Japanese autosomal recessive retinitis pigmentosa (ARRP) remains largely unknown. Herein, we applied a 2-step genome-wide association study (GWAS) in 640 Japanese patients. Meta-GWAS identified three independent peaks at P < 5.0 × 10-8, all within the major ARRP gene EYS. Two of the three were each in linkage disequilibrium with a different low frequency variant (allele frequency < 0.05); a known founder Mendelian mutation (c.4957dupA, p.S1653Kfs*2) and a non-synonymous variant (c.2528 G > A, p.G843E) of unknown significance. mRNA harboring c.2528 G > A failed to restore rhodopsin mislocalization induced by morpholino-mediated knockdown of eys in zebrafish, consistent with the variant being pathogenic. c.2528 G > A solved an additional 7.0% of Japanese ARRP cases. The third peak was in linkage disequilibrium with a common non-synonymous variant (c.7666 A > T, p.S2556C), possibly representing an unreported disease-susceptibility signal. GWAS successfully unraveled genetic causes of a rare monogenic disorder and identified a high frequency variant potentially linked to development of local genome therapeutics.
Comparison of adherence between fixed and unfixed topical combination glaucoma therapies using Japanese healthcare/pharmacy claims database: a retrospective non-interventional cohort study. International-journal

Chikako Shirai, Nobushige Matsuoka, Toru Nakazawa

BMC ophthalmology　21　(1)　52-52　2021/01/21

DOI： 10.1186/s12886-021-01813-w 　

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BACKGROUND: Adherence to chronic therapies is crucial to prevent the progression of disease, such as glaucoma. However, only a limited number of studies have investigated them using real-world data in Japan. This study aimed to evaluate Japanese patients' adherence to fixed- and unfixed-combination eye drops as a second-line therapy for glaucoma in real-world practice. METHODS: This retrospective, non-interventional cohort study utilized a commercially available Japanese healthcare database (MinaCare database). Medical/pharmacy claims data were collected from 2011 to 2016. The primary endpoint was adherence to medications, assessed by proportion of days covered (PDC) with medication during a 12-month post-index period. Meanwhile, the secondary endpoints included the persistence rate. RESULTS: A total of 738 patients were included in this study: 309 and 329 in the fixed- and unfixed-combination cohorts, respectively. Prostaglandin analog (PG)/β-blocker (BB) was most commonly claimed in 241/309 (78.0%) patients in the fixed-combination cohort. In the unfixed-combination cohort, PG and BB were claimed in 130/329 (39.5%) patients, whereas PG and α2-agonist were claimed in 87/329 (26.4%) patients. Patients were more adherent to the fixed-combination than the unfixed-combinations (mean PDCs [SD], 79.1% [32.1] vs. 62.2% [38.0]; P < 0.0001). The proportion of patients with good adherence (PDC ≥ 80%) was also higher in the fixed-combination cohort (69.6%) than in the unfixed-combination cohort (48.6%) (P < 0.0001). During the 12-month post-index period, the persistence rate was higher in the fixed-combination cohort than in the unfixed-combination cohort (47.6% [95% confidence intervals (CI): 41.9-53.0] vs. 24.9% [95% CI: 20.4-29.7], P < 0.0001). CONCLUSIONS: Japanese patients with glaucoma preferred the fixed-combination therapies over the unfixed-combination therapies. Hence, fixed-combination therapies would contribute to the improvement of adherence.
Omidenepag isopropyl ophthalmic solution for open-angle glaucoma and ocular hypertension: an update

Makoto Aihara, Tin Aung, Jason Bacharach, Louis Cantor, Michael Kook, Toru Nakazawa, Ki Ho Park, Da-Wen Lu

Expert Review of Ophthalmology　16　(4)　243-250　2021
Publisher: Taylor and Francis Ltd.
DOI： 10.1080/17469899.2021.1935241 　

ISSN： 1746-9902 1746-9899
Adherence and Persistence with First-Line Therapy and Compliance with Glaucoma Guidelines Using Japanese Health Care/Pharmacy Claims Database

Chikako Shirai, Nobushige Matsuoka, Toru Nakazawa

Journal of Ocular Pharmacology and Therapeutics　37　(1)　35-44　2021/01/01
Publisher: Mary Ann Liebert Inc.
DOI： 10.1089/jop.2020.0096 　

ISSN： 1557-7732 1080-7683
Association between aqueous humor cytokines and postoperative corneal endothelial cell loss after Descemet stripping automated endothelial keratoplasty. International-journal

Tatsu Okabe, Wataru Kobayashi, Takehiro Hariya, Shunji Yokokura, Toru Nakazawa

PloS one　16　(12)　e0260963　2021

DOI： 10.1371/journal.pone.0260963 　

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This study measured the intraoperative anterior aqueous humor concentrations of various cytokines during corneal endothelial transplantation and searched for relationships between these concentrations and postoperative corneal endothelial cell (CEC) depletion. We recruited 30 consecutive patients who underwent corneal endothelial transplantation with Descemet's stripping automated endothelial keratoplasty (DSAEK) at Tohoku University Hospital between February 2014 and July 2017. During surgery, we obtained aqueous humor samples and later measured the concentrations of 27 cytokines with a Multiplex Bead Assay (Bio-Plex Pro). We counted CECs 1, 6 and 12 months after surgery, and used Spearman's rank correlation coefficient to identify relationships between CEC depletion and the concentrations of detected cytokines. The loss of CECs 1-6 months after surgery was significantly correlated with IL-7, IP-10, MIP-1a and MIP-1b concentrations (-0.67, -0.48, -0.39, and -0.45, respectively, all P <0.01). CEC loss 1-12 months after surgery was significantly correlated with IL-1b, IL-7, IP-10 and RANTES concentrations (-0.46, -0.52, -0.48, and -0.43, respectively). Multiple regression analysis showed that IL-7 concentration was significantly associated with CEC loss 1-6 months after surgery (b = -0.65, P < 0.01) and IP-10 concentration was associated with CEC loss 1-12 months after surgery (β = -0.38, P < 0.05). These results suggest that not only inflammatory cytokines but also IL-7, a cytokine related to lymphocytes, may be involved in the depletion of CECs after DSAEK, particularly depletion that occurs relatively early.
The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma. International-journal

Noriko Himori, Maki Inoue Yanagimachi, Kazuko Omodaka, Yukihiro Shiga, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

Clinical ophthalmology (Auckland, N.Z.)　15　2293-2300　2021

DOI： 10.2147/OPTH.S314288 　

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Purpose: Oxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and Tamarindus indica) on markers of oxidative stress in patients with glaucoma. Patients and Methods: This study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett's test. Results: The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 (P < 0.001, P < 0.01, P < 0.01, P < 0.01), and BAP was significantly elevated at weeks 8 and 12 (P = 0.03, P = 0.04). In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 (P =0.03, P = 0.04), while BAP was not significantly elevated. Conclusion: An 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.
Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study. International-journal

Kazunobu Sugihara, Yasuyuki Takai, Ryo Kawasaki, Koji Nitta, Maki Katai, Yasushi Kitaoka, Yu Yokoyama, Kazuko Omodaka, Tomoko Naito, Takehiro Yamashita, Shiro Mizoue, Aiko Iwase, Toru Nakazawa, Masaki Tanito

PloS one　16　(7)　e0250245　2021

DOI： 10.1371/journal.pone.0250245 　

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The Glaucoma Stereo Analysis Study (GSAS) is a multicenter collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. This study evaluated the retinal vessel calibers and correlations using GSAS fundus photographs between retinal vessels and 38 optic nerve head (ONH) morphologic parameters comprehensively. In all 240 eyes, the mean central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were 138.4 and 216.5 μm, respectively; the CRAE correlated with age, visual field scores and 19 ONH parameters and CRVE correlated with age, intraocular pressure, visual field scores and 11 ONH parameters. Among the different optic disc appearances including focal ischemia (FI) (n = 53, 22%), generalized enlargement (GE) (n = 53, 22%), myopic glaucoma (MY) (n = 112, 47%), and senile sclerosis (SS) (n = 22, 9%), the CRAE did not differ significantly; CRVE was significantly narrower in SS than in FI and MY. In FI, GE, MY, and SS disc types, CRAE correlated with 3, 14, 9, and 2 ONH parameters, respectively, and CRVE corelated with 9, 0, 12, and 6 ONH parameters, respectively. We confirmed previous observations on the effect of retinal vessel narrowing on glaucomatous changes in the ONH and visual field. The associations between retinal vessel caliber and ONH morphologic parameters vary among different optic disc appearances, suggesting different effects of vascular changes in each disc type.
Ocular and Systemic Factors Affecting Laser Speckle Flowgraphy Measurements in the Optic Nerve Head. International-journal

Ayako Anraku, Nobuko Enomoto, Goji Tomita, Aiko Iwase, Takashi Sato, Nobuyuki Shoji, Tomoaki Shiba, Toru Nakazawa, Kazuhisa Sugiyama, Koji Nitta, Makoto Araie

Translational vision science & technology　10　(1)　13-13　2021/01

DOI： 10.1167/tvst.10.1.13 　

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Purpose: To investigate the ocular and systemic factors related to glaucoma and to be adjusted for interindividual comparison of ocular blood flow measurement results by laser speckle flowgraphy (LSFG) obtained from the optic nerve head (ONH) in normal Japanese individuals. Methods: A multicenter, prospective cross-sectional study was conducted. The ONH tissue-area and vessel-area mean blur rate (MT and MV) were evaluated using LSFG and ONH structural parameters using planimetric methods. Multivariate linear mixed-effects modeled regression analysis was used to identify the contributing factors to the MT and MV. The explanatory variables were age; gender; smoking history; body mass index; mean arterial pressure (MAP); heart rate; intraocular pressure; axial length (AL); disc, rim, cup, and β-peripapillary atrophy (β-PPA) areas; and central retinal artery and vein equivalents. Results: In total, 195 eyes of 126 healthy individuals with an average age of 48.1 years were included. Multivariate analysis showed that MAP and disc area had a negative (P < 0.001) correlation, whereas β-PPA area had a positive correlation with MT (P = 0.010). Age and AL had a negative correlation (P = 0.001 and P = 0.011, respectively), whereas cup area had a positive correlation (P = 0.012) with MV. Conclusions: Interindividual comparison of MT or MV must be adjusted for both systemic factors (blood pressure or age) and local ocular factors (AL and disc, cup, or β-PPA area). Translational Relevance: Our results provided reference data on the LSFG measurement and are important in comparing ocular blood flow between individuals using LSFG.
Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab. International-journal Peer-reviewed

Toshifumi Asano, Hiroshi Kunikata, Masayuki Yasuda, Koji M Nishiguchi, Toshiaki Abe, Toru Nakazawa

International ophthalmology　41　(1)　151-162　2021/01

DOI： 10.1007/s10792-020-01562-7 　

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PURPOSE: This study searched for early predictive vascular biomarkers for visual outcomes in eyes with macular edema caused by branch retinal vein occlusion (BRVOME). METHODS: Twenty-four eyes of 24 subjects with BRVOME were treated with the intravitreal injection of ranibizumab (IVR) for at least 6 months. We measured mean blur rate (MBR) in the optic nerve head (ONH) and vessel density (VD) in the macula with laser speckle flowgraphy and optical coherence tomography angiography, respectively. RESULTS: Six-month post-IVR best-corrected visual acuity (BCVA) was correlated positively with age, pre-IVR BCVA, 1-month post-IVR BCVA, 3-month post-IVR BCVA and pre-IVR systolic blood pressure (P < 0.001, P < 0.001, P < 0.001, P < 0.001 and P = 0.02, respectively) and negatively with pre-IVR overall MBR, 1-month post-IVR overall MBR, 6-month post-IVR overall MBR, 3-month post-IVR deep retinal capillary plexus (DCP) VD and 6-month post-IVR DCP VD (P = 0.03, P = 0.03, P = 0.02, P = 0.01 and P = 0.005, respectively). Furthermore, a multiple regression analysis showed that pre-IVR overall MBR (β = - 0.67, P = 0.009) was among independent prognostic factors predicting 6-month post-IVR BCVA. Six-month post-IVR DCP VD was also correlated with overall MBR at all time points. CONCLUSION: ONH blood flow may be a pre-IVR biomarker of both visual outcomes and post-IVR deep macular microcirculation in eyes with BRVOME.
RETINAL SENSITIVITY AND VESSEL DENSITY AFTER MACULAR HOLE SURGERY WITH THE SUPERIOR INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE. International-journal Peer-reviewed

Hiroshi Kunikata, Masayuki Yasuda, Naoko Aizawa, Urara Osada, Koji M Nishiguchi, Toshiaki Abe, Toru Nakazawa

Retina (Philadelphia, Pa.)　41　(1)　45-53　2021/01/01

DOI： 10.1097/IAE.0000000000002839 　

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PURPOSE: To evaluate retinal vessel density and retinal sensitivity (RS) after macular hole surgery with the superior inverted internal limiting membrane flap technique. METHODS: Retrospective, observational case series. Twenty-one patients with idiopathic macular hole underwent 27-gauge vitrectomy with the superior inverted internal limiting membrane flap technique and triamcinolone acetonide. Measurements included RS, which was measured with microperimetry, as well as retinal vessel density in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), which was measured with optical coherence tomography angiography. All parameters were evaluated in the superior and inferior sectors of the macula preoperatively and 1, 3, and 6 months postoperatively. RESULTS: Six months postoperatively, retinal thickness in the inferior sector was unchanged, but retinal thickness in the superior sector decreased significantly (P < 0.01). SCP vessel density in both sectors was unchanged at all postoperative time points. DCP vessel density in both sectors increased very significantly at 3 months (P < 0.01) and returned to baseline at 6 months. RS in the inferior sector increased by 47% 3 months postoperatively and by 61% 6 months postoperatively (P < 0.05 and P < 0.001, respectively), but RS in the superior sector increased only at 6 months postoperatively and only by 22% (P < 0.05). CONCLUSION: Lower recovery of RS in the superior sector suggests that internal limiting membrane peeling might affect the postoperative visual function.
Concurrent analogous organ damage in the brain, eyes, and kidneys in malignant hypertension: reversible encephalopathy, serous retinal detachment, and proteinuria. International-journal Peer-reviewed

Eikan Mishima, Yukino Funayama, Takehiro Suzuki, Fumiko Mishima, Fumihiko Nitta, Takafumi Toyohara, Koichi Kikuchi, Hiroshi Kunikata, Junichiro Hashimoto, Mariko Miyazaki, Hideo Harigae, Toru Nakazawa, Sadayoshi Ito, Takaaki Abe

Hypertension research : official journal of the Japanese Society of Hypertension　44　(1)　88-97　2021/01

DOI： 10.1038/s41440-020-0521-2 　

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Malignant hypertension, a form of hypertensive emergency, causes acute damage in vital organs such as the brain, eyes, and kidneys. We aimed to examine the concurrency of acute hypertensive damage across the target organs to elucidate the underlying analogous pathophysiology. This single-center retrospective study evaluated the characteristics of organ damage, short-term clinical course, and interorgan relationships in patients with malignant hypertension treated between 2008 and 2019. Baseline characteristics of 20 patients who met our inclusion criteria were mean age 48 ± 13 years and blood pressure 222 ± 18/142 ± 16 mmHg; the median estimated glomerular filtration rate and urinary protein level were 49 mL/min/1.73 m2 (interquartile range [IQR] 27-79) and 1.9 g/g creatinine (IQR 0.2-4.0), respectively. Posterior reversible encephalopathy syndrome (PRES) was found in 60% of patients with major involvement and a wide variety of distribution patterns in the brainstem. In the fundus, serous retinal detachment was found in 60% of patients. Patients with PRES and serous retinal detachment showed higher levels of urinary protein than those without symptoms (P = 0.007 and 0.02, respectively), and proteinuria >1 g/g creatinine highly complicated both PRES and serous retinal detachment (91%). Matrix analysis also showed that the three symptoms were highly associated with each other. These results demonstrate the close relationship and concurrency of hypertensive acute organ damage in the brain, eyes, and kidneys. A common analogous mechanism, such as hyperperfusion-induced capillary leakage in each organ, implies an underlying pathophysiology of PRES, serous retinal detachment, and proteinuria.
Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells. International-journal

Hiroshi Tawarayama, Noriyuki Suzuki, Maki Inoue-Yanagimachi, Noriko Himori, Satoru Tsuda, Kota Sato, Tomoaki Ida, Takaaki Akaike, Hiroshi Kunikata, Toru Nakazawa

Ocular immunology and inflammation　1-12　2020/11/20

DOI： 10.1080/09273948.2020.1833224 　

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We investigated the effects of glutathione trisulfide (GSSSG) on lipopolysaccharide (LPS)-induced inflammatory gene expression in immortalized ARPE-19, and primary human and mouse retinal pigment epithelial (RPE) cells. Sulfane sulfur molecules were significantly increased in GSSSG-treated ARPE-19 cells. GSSSG prevented the LPS-induced upregulation of interleukin (IL)-1β, IL-6, and C-C motif chemokine ligand 2 (CCL2) in ARPE-19/primary RPE cells. Moreover, GSSSG prevented the activation of the nuclear factor-kappa B p65 subunit, and promoted the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in LPS-treated ARPE-19 cells. ERK1/2 inhibition prevented the GSSSG-mediated inhibition of LPS-induced IL-6 and CCL2 upregulation. Additionally, ERK1/2 activation prevented the upregulation of these genes in the absence of GSSSG. Knockdown of HMOX1 or NRF2, known as anti-oxidative genes, did not affect the activity of GSSSG in the context of LPS stimulation. These findings suggest that GSSSG attenuates LPS-induced inflammatory gene expression via ERK signaling hyperactivation, independently of the NRF2/HMOX1 pathway.
Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe. International-journal Peer-reviewed

Toshifumi Asano, Yuri Nagayo, Satoru Tsuda, Azusa Ito, Wataru Kobayashi, Kosuke Fujita, Kota Sato, Koji M Nishiguchi, Hiroshi Kunikata, Hiroyoshi Fujioka, Mako Kamiya, Yasuteru Urano, Toru Nakazawa

Bioconjugate chemistry　31　(9)　2241-2251　2020/09/16

DOI： 10.1021/acs.bioconjchem.0c00435 　

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Calpain activation induces retinal ganglion cell (RGC) death, while calpain inhibition suppresses RGC death, in animal studies. However, the role of calpain in human retinal disease is unclear. This study investigated a new strategy to study the role of calpain based on real-time imaging. We synthesized a novel fluorescent probe for calpain, acetyl-l-leucyl-l-methionine-hydroxymethyl rhodamine green (Ac-LM-HMRG) and used it for real-time imaging of calpain activation. The toxicity of Ac-LM-HMRG was evaluated with a lactate dehydrogenase cytotoxicity assay, retinal sections, and electroretinograms. Here, we performed real-time imaging of calpain activation in a rat model. First, we administered N-methyl-d-aspartate (NMDA) to induce retinal injury. Twenty minutes later, we administered an intravitreal injection of Ac-LM-HMRG. Real-time imaging was then completed with a noninvasive confocal scanning laser ophthalmoscope. The inhibitory effect of SNJ-1945 against calpain activation was also examined with the same real-time imaging method. Ac-LM-HMRG had no toxic effects. The number of Ac-LM-HMRG-positive cells in real-time imaging significantly increased after NMDA injury, and SNJ-1945 significantly lowered the number of Ac-LM-HMRG-positive cells. Real-time imaging with Ac-LM-HMRG was able to quickly quantify the NMDA-induced activation of calpain and the inhibitory effect of SNJ-1945. This technique, used as a companion diagnostic system, may aid research into the development of new neuroprotective therapies.
One after another retinal involvement in lupus. International-journal Peer-reviewed

Tomoyuki Mutoh, Yuko Shirota, Azusa Ito, Hiroshi Fujii, Tomonori Ishii, Toru Nakazawa, Hideo Harigae

European journal of rheumatology　8　(2)　111-2　2020/09/03

DOI： 10.5152/eurjrheum.2020.20022 　
隅角閉塞を伴った常染色体劣性ベストロフィン症の1例

西口康二, 国松志保, 國方彦志, 中澤徹

日本眼科学会雑誌　124　(9)　720-725　2020/09
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Clinical characteristics and high resolution retinal imaging of retinitis pigmentosa caused by RP1 gene variants. Peer-reviewed

Shinji Ueno, Yoshito Koyanagi, Taro Kominami, Yasuki Ito, Kenichi Kawano, Koji M Nishiguchi, Carlo Rivolta, Toru Nakazawa, Koh-Hei Sonoda, Hiroko Terasaki

Japanese journal of ophthalmology　64　(5)　485-496　2020/09

DOI： 10.1007/s10384-020-00752-1 　

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PURPOSE: To report the clinical course and high resolution images of autosomal recessive retinitis pigmentosa (RP) associated with a variant of the RP1 gene (c.4052_4053ins328/p.Tyr1352Alafs*9; m1), a high frequency founder variant in Japanese RP patients. STUDY DESIGN: Retrospective case series. METHODS: Nine patients from 5 unrelated Japanese families were studied. Five patients had the m1 variant homozygously, and 4 patients had the m1 variant compound heterozygously with another frameshift variant (c.4196delG/p.Cys1399Leufs*5). Ophthalmic examinations including adaptive optics (AO) fundus imaging were performed periodically. RESULTS: The fundus photographs, fundus autofluorescence (FAF) images, and optical coherence tomographic (OCT) images indicated severe retinal degeneration in all the patients involving the macula even at a young age (20 s). The areas of surviving photoreceptors in the central macula were seen as hyper-autofluorescent regions in the FAF images and preserved outer retinal structure in the OCT images; they were identifiable in the AO fundus images in 8 eyes. The borders of the surviving photoreceptor areas were surrounded by hyporeflective clumps, presumably containing melanin, and the size of these areas decreased progressively during the 4-year follow-up period. The disappearance of the surviving photoreceptor areas was associated with complete blindness. CONCLUSION: Patients with RP associated with the m1 variant have a progressive and severe retinal degeneration that begins at an early age. Monitoring the surviving photoreceptor areas by AO fundus imaging can provide a more precise pathological record of retinal degeneration.
Successful surgical outcomes after 23-, 25- and 27-gauge vitrectomy without scleral encircling for giant retinal tear. Peer-reviewed

Hiroshi Kunikata, Naoko Aizawa, Risa Sato, Koji M Nishiguchi, Toshiaki Abe, Toru Nakazawa

Japanese journal of ophthalmology　64　(5)　506-515　2020/09

DOI： 10.1007/s10384-020-00755-y 　

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PURPOSE: Retinal detachment due to giant retinal tears (GRTs), tears larger than 90°, is rare and difficult to treat. Here, we show and compare surgical results of 23-, 25- and 27-gauge (G) micro-incision vitrectomy surgery (MIVS) for GRT. STUDY DESIGN: Retrospective and interventional case series. METHODS: Retrospective review of 41 eyes of 38 patients with GRT who underwent MIVS. Surgical outcomes after MIVS, including reattachment rates and postoperative complications, were compared between instrument gauges. All patients were followed for at least 6 months postoperatively. RESULTS: MIVS with 23G, 25G and 27G instruments was performed in 7, 19 and 15 eyes, respectively. Silicone oil (SO) was used in 34 of 41 eyes (83%) with a mean removal time of 43.8 days after first surgery. Best-corrected visual acuity (BCVA) was recovered or maintained in 39 eyes (95%). Reattachment was attained after initial surgery in 38 of 41 eyes (93%) (23G: 6/7 [86%]; 25G: 17/19 [89%]; 27G: 15/15 [100%]). Final reattachment was eventually achieved in all eyes (two eyes needed support from scleral encircling). Postoperative complications occurred in 16 eyes (39%) (23G: 3/7 [43%]; 25G: 8/19 [42%]; 27G: 5/15 [33%]), including macular pucker, cystoid macular edema, macular hole, subretinal perfluorocarbon liquid, retinal folds, vitreous hemorrhage and redetachment. There were no significant differences between the three groups in rate of high myopia, GRT size, operation time, phacovitrectomy rate, SO usage rate, initial reattachment rate, final reattachment rate, preoperative BCVA, final BCVA or rate of postoperative complications. CONCLUSION: Despite occasional postoperative complications, primary MIVS, regardless of gauge size, appears to be a safe and feasible option for GRT surgery.
Association of retinal vessel density with retinal sensitivity in surgery for idiopathic epiretinal membrane. International-journal Peer-reviewed

Urara Osada, Hiroshi Kunikata, Masayuki Yasuda, Kazuki Hashimoto, Koji M Nishiguchi, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　258　(9)　1911-1920　2020/09

DOI： 10.1007/s00417-020-04754-0 　

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PURPOSE: The success of surgical treatment for idiopathic epiretinal membrane (ERM) is measured by postoperative best-corrected visual acuity (BCVA), metamorphopsia, and foveal retinal sensitivity (RS).This study searched for predictive biomarkers of surgical success by determining the association between foveal RS and various aspects of vessel density (VD) in the fovea of patients with ERM. METHODS: The study examined 25 eyes of 25 patients with ERM who underwent 27-gauge microincision vitrectomy surgery (MIVS). RS was measured with microperimetry (MP-3; NIDEK) at four central points in the fovea with an interpoint distance of 2°. VD was measured with SD-OCT (RS 3000; NIDEK) within the 1-mm2 square defined by the 4 RS points at various depths, including the superficial and deep retinal capillary plexus (SCP and DCP, respectively). RESULTS: Though VD did not change throughout the follow-up period, BCVA and RS significantly improved 1 and 3 months after surgery, respectively (both P < 0.0017). Postoperative RS at 6 months was positively correlated with postoperative DCP VD at 1, 3, and 6 months (r = 0.62, P = 0.001; r = 0.40, P = 0.049; r = 0.53, P = 0.007, respectively), but not with SCP VD at any time point. Multiple regression analysis confirmed that postoperative RS at 6 months was associated with postoperative DCP VD at 1 month (P = 0.03). CONCLUSION: Higher postoperative DCP VD at 1 month contributed to better postoperative foveal RS at 6 months. Early postoperative VD in the fovea might be a useful predictive biomarker of late postoperative RS in the fovea in ERM patients.
Response to the letter re "CPAP therapy reduces oxidative stress in patients with glaucoma and OSAS and improves the visual field". International-journal Peer-reviewed

Noriko Himori, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　2020/07/28

DOI： 10.1007/s00417-020-04824-3 　
Effect of the chemical structure on the drug release from brinzolamide based nano eye-drops

Yoshitaka Koseki, Yoshikazu Ikuta, Kota Sato, Shigenobu Aoyagi, Satoshi Inada, Tsunenobu Onodera, Hidetoshi Oikawa, Koji M. Nishiguchi, Toru Nakazawa, Hitoshi Kasai

Molecular Crystals and Liquid Crystals　706　(1)　122-128　2020/07/23
Publisher: Informa UK Limited
DOI： 10.1080/15421406.2020.1743447 　

ISSN： 1542-1406

eISSN： 1563-5287
Vascular resistance of carotid and vertebral arteries is associated with retinal microcirculation measured by laser speckle flowgraphy in patients with type 2 diabetes mellitus. International-journal Peer-reviewed

Shojiro Sawada, Satoko Tsuchiya, Shinjiro Kodama, Satoko Kurosawa, Akira Endo, Hiroto Sugawara, Shinichiro Hosaka, Yohei Kawana, Yoichiro Asai, Junpei Yamamoto, Yuichiro Munakata, Tomohito Izumi, Kei Takahashi, Keizo Kaneko, Junta Imai, Azusa Ito, Masayuki Yasuda, Hiroshi Kunikata, Toru Nakazawa, Hideki Katagiri

Diabetes research and clinical practice　165　108240-108240　2020/06/02

DOI： 10.1016/j.diabres.2020.108240 　

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AIMS: Evaluation of the retinal microcirculation is key to understanding retinal vasculopathies, such as diabetic retinopathy. Laser speckle flowgraphy (LSFG) has recently enabled us to directly evaluate the vascular resistance in both retinal vessels and capillaries, non-invasively. We therefore assessed whether retinal vessel blood flow and/or the capillary microcirculation are associated with blood flow in the cervical arteries in diabetic patients without severe retinopathy. METHODS: We enrolled 110 type 2 diabetes patients, with no or mild non-proliferative diabetic retinopathy, in this prospective cross-sectional study. We measured the resistivity indices (RIs) of the retinal vessel and capillaries by LSFG and those of cervical arteries by Doppler ultrasonography, followed by analyzing associations. RESULTS: The RIs of not only the carotid but also vertebral arteries were associated with those of retinal vessel blood flow and the retinal capillary microcirculation. Multiple regression analyses revealed these associations to be independent of other explanatory variables including age and diabetes duration. CONCLUSIONS: We obtained novel and direct evidence demonstrating a close association between the retinal microcirculation and cervical artery hemodynamics in diabetic patients. These findings suggest shared mechanisms to underlie micro- and macro-angiopathies. Thus, high vascular resistance of cervical arteries may be a risk of developing retinopathy.
A case of eyelid adhesion caused by sebaceous adenocarcinoma and inability to open eyes Peer-reviewed

阿部真以子, 檜森紀子, 二宮高洋, 高木尚之, 竹下孝之, 齊藤涼子, 中澤徹

臨床眼科　74　(6)　759-764　2020/06
Publisher:
ISSN： 0370-5579

eISSN： 1882-1308
Signs of Oguchi Disease and Pigmentary Degeneration from Early in Life. International-journal Peer-reviewed

Koji M Nishiguchi, Hiroshi Kunikata, Toru Nakazawa

Ophthalmology　127　(6)　825-825　2020/06

DOI： 10.1016/j.ophtha.2020.02.020 　
Concomitant herpes simplex keratitis and autoimmune-associated ulcerative keratitis in rheumatoid arthritis patients. International-journal Peer-reviewed

Masaaki Yoshida, Takehiro Hariya, Shunji Yokokura, Wataru Kobayashi, Ryu Watanabe, Tomonori Ishii, Toru Nakazawa

American journal of ophthalmology case reports　18　100648-100648　2020/06

DOI： 10.1016/j.ajoc.2020.100648 　

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Purpose: To describe four cases of concomitant herpes simplex keratitis (HSK) and autoimmune-associated ulcerative keratitis (UK) in patients with rheumatoid arthritis (RA). Observations: All patients developed HSK and UK while undergoing treatment for RA. The average age of onset for RA, UK and HSK was 49.3, 69.5 and 70.5 years, respectively. UK preceded HSK in three cases and followed HSK in one case. Two patients had bilateral UK and two had unilateral UK. HSK was unilateral in all cases. All the cases had been treated with immunosuppressive agents including steroid, methotrexate, calcineurin inhibitors, etanercept and tocilizumab at the onset of HSK. Every patient was treated for HSK with topical acyclovir ointment combined with oral valacyclovir. The final visual outcome was extremely poor despite intensive therapy. Conclusions and Importance: These cases raise the possibility that RA patients have an increased risk of HSK, and that HSK may tend to be severe in these patients because of their immunocompromised condition. Furthermore, the complication of HSK and UK in RA patients is difficult to treat because of the atypical clinical manifestation. Thus, the emergence of corneal ulcer, especially in patients with a long clinical history of RA, calls for careful follow-up.
Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography. International-journal Peer-reviewed

Maiko Abe, Kazuko Omodaka, Tsutomu Kikawa, Toru Nakazawa

BMC ophthalmology　20　(1)　199-199　2020/05/24

DOI： 10.1186/s12886-020-01453-6 　

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BACKGROUND: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH). METHODS: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch's t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). RESULTS: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p < 0.001), but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o'clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall (p = 0.391) or in the superior quadrant (p = 0.268), while RPC density was significantly higher in the inferior (p = 0.005) and temporal quadrants (p < 0.001) and lower in the nasal quadrant (p = 0.029). CONCLUSIONS: Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.
Progression in Open-Angle Glaucoma with Myopic Disc and Blood Flow in the Optic Nerve Head and Peripapillary Chorioretinal Atrophy Zone

Naoki Kiyota, Yukihiro Shiga, Nana Takahashi, Masayuki Yasuda, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

Ophthalmology Glaucoma　3　(3)　202-209　2020/05/01
Publisher: American Academy of Ophthalmology
DOI： 10.1016/j.ogla.2020.03.005 　

ISSN： 2589-4196 2589-4234
経角膜硝子体切除を併用した眼内レンズ強膜内固定術3症例の検討 Peer-reviewed

新田文彦, 國方彦志, 大友孝昭, 西口康二, 阿部俊明, 中澤徹

臨床眼科　74　(5)　582-588　2020/05
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
What is glaucomatous optic neuropathy? Peer-reviewed

Toru Nakazawa, Takeo Fukuchi

Japanese journal of ophthalmology　64　(3)　243-249　2020/05

DOI： 10.1007/s10384-020-00736-1 　

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Glaucomatous optic neuropathy (GON) is the pathohistological feature of glaucoma in the optic nerve. The pathogenesis of GON has been hypothesized, to either originate from compromised mechanical conditions at the lamina cribrosa or as associated with pathological vascular involvement. From a historical perspective, glaucoma is the degeneration of retinal ganglion cells (RGC) due to the elevation of intraocular pressure (IOP). The consensus of glaucoma treatment is generally accepted as sufficient IOP reduction. Is there an additional option to treat GON from the perspective of the vascular theory? In this section, two distinguished leaders in glaucoma research advance their views and discuss the current opinions surrounding the two theories regarding the causes of GON in primary open angle glaucoma (POAG) and normal tension glaucoma (NTG).
Systemic oxidative stress level in patients with central serous chorioretinopathy. International-journal Peer-reviewed

Hiroshi Kunikata, Risa Sato, Koji M Nishiguchi, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　258　(7)　1575-1577　2020/04/08

DOI： 10.1007/s00417-020-04664-1 　
Identification of novel biomarkers of hepatocellular carcinoma by high-definition mass spectrometry: Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging. International-journal Peer-reviewed

Koshi Nagai, Baasanjav Uranbileg, Zhen Chen, Amane Fujioka, Takahiro Yamazaki, Yotaro Matsumoto, Hiroki Tsukamoto, Hitoshi Ikeda, Yutaka Yatomi, Hitoshi Chiba, Shu-Ping Hui, Toru Nakazawa, Ritsumi Saito, Seizo Koshiba, Junken Aoki, Daisuke Saigusa, Yoshihisa Tomioka

Rapid communications in mass spectrometry : RCM　34 Suppl 1　(Suppl 1)　e8551　2020/04

DOI： 10.1002/rcm.8551 　

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RATIONALE: Hepatocellular carcinoma (HCC) is a highly malignant disease for which the development of prospective or prognostic biomarkers is urgently required. Although metabolomics is widely used for biomarker discovery, there are some bottlenecks regarding the comprehensiveness of detected features, reproducibility of methods, and identification of metabolites. In addition, information on localization of metabolites in tumor tissue is needed for functional analysis. Here, we developed a wide-polarity global metabolomics (G-Met) method, identified HCC biomarkers in human liver samples by high-definition mass spectrometry (HDMS), and demonstrated localization in cryosections using desorption electrospray ionization MS imaging (DESI-MSI) analysis. METHODS: Metabolic profiling of tumor (n = 38) and nontumor (n = 72) regions in human livers of HCC was performed by an ultrahigh-performance liquid chromatography quadrupole time-of-flight MS (UHPLC/QTOFMS) instrument equipped with a mixed-mode column. The HCC biomarker candidates were extracted by multivariate analyses and identified by matching values of the collision cross section and their fragment ions on the mass spectra obtained by HDMS. Cryosections of HCC livers, which included both tumor and nontumor regions, were analyzed by DESI-MSI. RESULTS: From the multivariate analysis, m/z 904.83 and m/z 874.79 were significantly high and low, respectively, in tumor samples and were identified as triglyceride (TG) 16:0/18:1(9Z)/20:1(11Z) and TG 16:0/18:1(9Z)/18:2(9Z,12Z) using the synthetic compounds. The TGs were clearly localized in the tumor or nontumor areas of the cryosection. CONCLUSIONS: Novel biomarkers for HCC were identified by a comprehensive and reproducible G-Met method with HDMS using a mixed-mode column. The combination analysis of UHPLC/QTOFMS and DESI-MSI revealed that the different molecular species of TGs were associated with tumor distribution and were useful for characterizing the progression of tumor cells and discovering prospective biomarkers.
Endogenous endophthalmitis caused by group B streptococcus; case reports and review of 35 reported cases. International-journal Peer-reviewed

Masaaki Yoshida, Shunji Yokokura, Takashi Nishida, Kiyofumi Mochizuki, Takashi Suzuki, Kazuichi Maruyama, Takaaki Otomo, Koji M Nishiguchi, Hiroshi Kunikata, Toru Nakazawa

BMC ophthalmology　20　(1)　126-126　2020/03/31

DOI： 10.1186/s12886-020-01378-0 　

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BACKGROUND: Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE). However, the number of invasive GBS infections is increasing, particularly in elderly patients with underlying conditions such as diabetes mellitus (DM), cardiovascular disease and cancer. We report 6 cases of EBE caused by GBS and review the literature. METHODS: Retrospective case series and literature review. RESULTS: In the current case series, 6 eyes of 6 patients developed EBE caused by GBS. The average age was 73.5 years. The focus of infection included the urinary tract, cellulitis, arthritis, peritonitis, catheter-associated infection and endocarditis. Four patients had DM. While all 6 strains were sensitive to β-lactams (penicillins and cephems), 4 strains were resistant to levofloxacin (no data for 1 isolate). Each case was treated with the systemic antibiotic to which the individual strain was sensitive. All cases showed poor visual acuity at presentation (decimal visual acuity: less than 0.03). Vitrectomy with intravitreal antibiotics injection was performed in 4 cases. Visual acuity recovered in 4 cases and did not recover in 2 cases, even after vitrectomy. The literature review of 53 eyes of 41 patients revealed that 60% of eyes finally lost all vision, and death occurred in 2 cases. Initial visual acuity of less than counting fingers was associated with a final outcome of lost vision. Of 41 patients, 13 (32%) had DM as an underlying medical condition. The most common extra-ocular infection focus was endocarditis (37%). CONCLUSIONS: DM is common in patients with EBE caused by GBS. While the 4 cases in the current report had a relatively good visual acuity outcome, despite poor initial visual acuity, the literature review indicated that EBE caused by GBS is generally a severe condition with a poor prognosis. The current study also indicates the importance of considering the possibility of endocarditis on encountering EBE caused by GBS.
Genetic variants associated with the onset and progression of primary open-angle glaucoma. International-journal Peer-reviewed

Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Hiroyuki Iijima, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuki Hashimoto, Kota Sato, Yukihiro Shiga, Koji M Nishiguchi, Toru Nakazawa, Masato Akiyama, Kazuhide Kawase, Mineo Ozaki, Makoto Araie

American journal of ophthalmology　215　135-140　2020/03/23

DOI： 10.1016/j.ajo.2020.03.014 　

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PURPOSE: To investigate the genetic variants associated with the onset and progression of primary open-angle glaucoma (POAG). DESIGN: Case-control genetic association study. METHODS: Japanese POAG patients (n=505) and control subjects (n=246) were genotyped for 22 genetic variants predisposing to POAG that can be classified into those associated with intraocular pressure (IOP) elevation (IOP-related genetic variants) and optic nerve vulnerability independent of IOP (non-IOP-related genetic variants). The total number of risk alleles of the 17 IOP-related and 5 non-IOP-related genetic variants were calculated as the genetic risk score (GRS), and the associations between the GRS and family history of glaucoma as an indicator of POAG onset and age at the diagnosis of glaucoma as an indicator of POAG progression were evaluated. RESULTS: There was a significant association (P=0.014, odds ratio: 1.26 per GRS) between the non-IOP-related GRS, but not IOP-related GRS, and a family history of glaucoma in POAG. As the non-IOP-related GRS increased, the risk of a family history of glaucoma increased. In contrast, a significant association (P=0.0014, Beta=-0.14) was found between the IOP-related GRS, but not non-IOP-related GRS, and age at the diagnosis of glaucoma. As the IOP-related GRS increased, age at the diagnosis of glaucoma decreased. CONCLUSIONS: The results indicate that non-IOP-related (optic nerve vulnerability) rather than IOP-related (IOP elevation) genetic variants may play an important role in the onset of POAG (family history of glaucoma) and that IOP-related rather than non-IOP-related genetic variants may play an important role its progression (age at the diagnosis of glaucoma).
A founder Alu insertion in RP1 gene in Japanese patients with retinitis pigmentosa. Peer-reviewed

Koji Miura Nishiguchi, Kosuke Fujita, Yasuhiro Ikeda, Hiroshi Kunikata, Yoshito Koyanagi, Masato Akiyama, Toshiaki Abe, Yuko Wada, Koh-Hei Sonoda, Toru Nakazawa

Japanese journal of ophthalmology　64　(4)　346-350　2020/03/19

DOI： 10.1007/s10384-020-00732-5 　

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PURPOSE: To screen for the 328 bp Alu insertion (c.4052_4053ins328, p.Tyr1352Alafs) in RP1 in a group of retinitis pigmentosa (RP) patients who had been previously identified with a heterozygous deleterious mutation in the gene. STUDY DESIGN: Prospective, clinical and experimental study. METHODS: The Alu insertion in RP1 was screened with an optimized PCR-based method in 26 RP patients with a heterozygous deleterious mutation (nonsense or frameshift) in RP1 that had been identified in a preceding genetic study. The genetic location of the previously identified mutation and its inheritance pattern were assessed. RESULTS: Out of 26 RP patients with a heterozygous deleterious mutation in RP1, 5 (19.2%) were found to carry an additional heterozygous Alu insertion, presumably resulting in a compound heterozygous state. This included 3 patients who had been previously diagnosed as autosomal dominant RP based on genetic findings. They were re-diagnosed as having an autosomal recessive disease following our new findings. In all patients identified with the Alu insertion, the other mutations found in the preceding study were outside the defined region in exon 4 (encoding amino acids 677 to 917) in which truncation mutations have been suggested to exert a dominant negative effect. CONCLUSION: The founder Alu insertion in RP1 is an important cause of autosomal recessive RP in Japanese patients and can be missed in standard targeted resequencing. Screening optimized for this mutation is warranted, particularly in patients with a heterozygous deleterious mutation outside the defined region in exon 4 of RP1.
Serum AQP4-IgG level is associated with the phenotype of the first attack in neuromyelitis optica spectrum disorders. International-journal Peer-reviewed

Tetsuya Akaishi, Toshiyuki Takahashi, Noriko Himori, Kazuo Fujihara, Tatsuro Misu, Michiaki Abe, Tadashi Ishii, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

Journal of neuroimmunology　340　577168-577168　2020/03/15

DOI： 10.1016/j.jneuroim.2020.577168 　

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We aimed in this study to elucidate the impact of serum AQP4-IgG titer before starting treatments to the clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD). Serum titer at the onset, measured using live cell-based assay method, did not correlate to the subsequent relapse rate or neurological prognosis. Patients with optic neuritis as the first attack showed significantly higher serum titer than patients with acute myelitis or area postrema syndrome, although the titer did not correlate to the visual prognosis. The result implies that the pathological mechanism of optic neuritis and acute myelitis could be different in NMOSD.
Structural Characterization of Glaucoma Patients with Low Ocular Blood Flow. International-journal Peer-reviewed

Kazuko Omodaka, Shunsuke Fujioka, Guangzhou An, Takuma Udagawa, Satoru Tsuda, Yukihiro Shiga, Soichiro Morishita, Tsutomu Kikawa, Kyongsun Pak, Masahiro Akiba, Hideo Yokota, Toru Nakazawa

Current eye research　45　(10)　1-7　2020/03/12

DOI： 10.1080/02713683.2020.1736306 　

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Purpose: There is an unclear relationship between ocular blood flow (OBF) and the structural characteristics of the optic nerve head (ONH) in glaucoma, a multifactorial disease. This study used laser speckle flowgraphy (LSFG) to identify low-OBF glaucoma patients and investigated the ONH in these patients.Materials and Methods: In 533 eyes with glaucoma, we determined confounding factors for LSFG-measured OBF (tissue-area mean blur rate: MT) and corrected MT with a linear mixed-effects model (LMM). Structural ONH data (from fundus stereo photography), OCT data, and clinical characteristics were then compared in patients with corrected MT in the upper and lower quartiles using the LMM.Results: Single regression showed significant correlations between MT and age, spherical equivalent (SE), central corneal thickness (CCT), and a weighted count of retinal ganglion cells (wRGC), but not axial length or systemic blood pressure. Gender also significantly influenced MT; MT was corrected for these correlated factors and also glaucoma type with the LMM. The lower-quartile MT group had a significantly larger cup area and cup-disc area ratio and lower temporal quadrant circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular ganglion cell complex (GCC) than the upper-quartile group.Conclusions: Low-OBF glaucoma patients were characterized by a larger cup-disc ratio, and higher susceptibility to damage in the temporal disc and the macular area.
A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury. International-journal Peer-reviewed

Kota Sato, Seiya Mochida, Daisuke Tomimoto, Takahiro Konuma, Naoki Kiyota, Satoru Tsuda, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Experimental eye research　193　107997-107997　2020/03/09

DOI： 10.1016/j.exer.2020.107997 　

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We aimed to assess the neuroprotective effect of a pyruvate dehydrogenase kinase (PDK) inhibitor, Nov3r after ischemia/reperfusion (IR) injury in rats. IR injury was induced by applying 150 mmHg of intraocular pressure for 50 min. Nov3r was orally administered (100 mg/kg) 3 h before and 24 h after IR injury. TUNEL-positive cells increased and immunoreactive RBPMS-positive cells decreased in the rat retinas after IR injury. Administration of Nov3r significantly ameliorated the increase in TUNEL-positive cells and prevented the RBPMS-positive cell decrease. Similarly, the number of IR-induced Iba1-positive microglial cells was significantly reduced with Nov3r treatment. Among metabolic parameters, IR damage induced the elevation of lactate and pyruvate, and the reduction of ATP. Oral administration of Nov3r ameliorated these changes. Our data suggest that the Nov3r had a retinal neuroprotective effect in IR injury in rats. This finding suggests that the regulation of pyruvate dehydrogenase (PDH) activity has potential therapeutic value by enabling metabolic reprograming in diseases associated with ischemic retinal damage, such as diabetic retinopathy, retinopathy of prematurity, retinal vein occlusion, ischemic optic neuropathy and glaucoma.
Association of CRX genotypes and retinal phenotypes confounded by variable expressivity and electronegative electroretinogram. International-journal Peer-reviewed

Koji M Nishiguchi, Hiroshi Kunikata, Kosuke Fujita, Kazuki Hashimoto, Yoshito Koyanagi, Masato Akiyama, Yasuhiro Ikeda, Yukihide Momozawa, Koh-Hei Sonoda, Akira Murakami, Yuko Wada, Toru Nakazawa

Clinical & experimental ophthalmology　48　(5)　644-657　2020/02/29

DOI： 10.1111/ceo.13743 　

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IMPORTANCE: A framework for understanding the phenotypic features of CRX retinopathy was established. BACKGROUND: To perform a phenotype-genotype correlation analysis in two groups of patients with heterozygous mutations in distinct locations of the CRX gene, encoding the cone-rod homeobox. DESIGN: Multicentre retrospective study. PARTICIPANTS: Twenty-one Japanese patients from 14 families with a heterozygous CRX mutation. METHODS: Retrospective data analysis. MAIN OUTCOME MEASURES: Clinical records on CRX mutation, symptoms, best-corrected visual acuity (BCVA), visual field, fundus photography, fundus auto-fluorescence, optical coherence tomography and electroretinograms (ERGs). RESULTS: Six different CRX heterozygous mutations were identified in the subjects. Twelve patients from 9 families shared the p.R41W mutation and 1 patient had the p.R43C mutation, both of which affect the homeobox domain of CRX. These patients often displayed adult-onset retinal dystrophy with macular degeneration. In contrast, five patients with downstream mutations (p.S204fs, p.S213fs, p.G243X and p.L299F) displayed retinal degeneration or macular degeneration with bone-spicule pigmentation. Three asymptomatic carriers with different mutations (p.R41W, p.S213fs and p.G243X) were present in both groups. Nearly all patients and carriers had an electronegative ERG in response to a bright flash under dark adaptation. There was no cross-sectional association between patients' age and BCVA, despite progressive decline in BCVA. CONCLUSIONS AND RELEVANCE: Heterozygous mutations within or downstream of the homeobox domain in CRX relate to the difference associated retinal phenotypes, which was confounded by variable expressivity and electronegative ERGs. CRX mutations should be considered in patients with an electronegative ERG with minimal or no macular changes.
Serum anti-recoverin antibodies is found in elderly patients with retinitis pigmentosa and cancer. International-journal Peer-reviewed

Taimu Sato, Koji M Nishiguchi, Kosuke Fujita, Fuyuki Miya, Takashi Inoue, Erika Sasaki, Toshifumi Asano, Satoru Tsuda, Yukihiro Shiga, Hiroshi Kunikata, Mitsuru Nakazawa, Toru Nakazawa

Acta ophthalmologica　98　(6)　e722-e729　2020/02/11

DOI： 10.1111/aos.14373 　

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PURPOSE: To screen for anti-recoverin antibodies in elderly patients with retinitis pigmentosa (RP) with or without cancer and cross-sectionally characterize the seropositive patients clinically. METHODS: Serum from 75 RP patients who had been tested for mutations in a panel of 83 RP genes and 73 normal controls, all aged 50-80 years, were screened for anti-recoverin antibodies by Western blot using recombinant recoverin, retinal lysate from a marmoset and commercial anti-recoverin antibodies as a control. RESULTS: Three RP patients with typical pigmentary degeneration of the 75 (4.0%) were seropositive for anti-recoverin antibody. Pathogenic mutations were identified in two seropositive RP patients. All three patients had visual impairment since childhood and were diagnosed as RP by the age of 30. The severity of the retinopathy varied greatly among these three patients, ranging in visual acuity from light perception OU to 20/30 OU. Retinitis pigmentosa (RP) patients with a history of cancer were more likely to have anti-recoverin antibodies (3/14; 21.4%) than those without (0/61; 0%; p = 0.005, Fischer exact test). All 73 healthy controls with no history of cancer were also seronegative. CONCLUSION: Our results show that serum anti-recoverin antibodies can be detected in typical RP patients with identified pathogenic mutations and that a history of cancer may increase the risk of developing anti-recoverin antibodies.
The optic nerve head vasoreactive response to systemic hyperoxia and visual field defect progression in open-angle glaucoma, a pilot study. International-journal Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Kyongsun Pak, Hiroshi Kunikata, Toru Nakazawa

Acta ophthalmologica　98　(6)　e747-e753　2020/02/11

DOI： 10.1111/aos.14361 　

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PURPOSE: To investigate the effect of optic nerve head (ONH) tissue vasoreactivity on glaucoma visual field defect progression. METHODS: This prospective, longitudinal study comprised 28 eyes of 16 patients with open-angle glaucoma. Baseline data were obtained from oxygen inhalation testing, including laser speckle flowgraphy measurements of tissue-area mean blur rate (MT), which represents ONH tissue blood flow, and the mean percentage change in MT (MT-change). Follow-up data were collected for at least 2 years, including at least 5 reliable visual field tests. The average total deviation (TD) was calculated in each sector of the Garway-Heath map; in this study, superior, central and inferior TD corresponded to inferior, temporal and superior MT or MT-change, respectively. MT and MT-change in three sectors per eye were included as explanatory variables in a multivariable linear mixed-effects model, with TD slope set as the response variable. RESULTS: At baseline, lower MT and higher diastolic blood pressure were associated with lower MT-change (p < 0.05). Additionally, MT-change significantly contributed to TD slope in the corresponding sectors (β = 0.41, p = 0.01). CONCLUSIONS: Weaker ONH tissue vasoreactivity to systemic hyperoxia, assessed with laser speckle flowgraphy, was associated with lower baseline ONH tissue blood flow, higher diastolic blood pressure and rapid visual field defect progression. Laser speckle flowgraphy variables during oxygen provocation testing may represent potentially useful predictive biomarkers of glaucoma progression.
Duane症候群との鑑別に苦慮した重症筋無力症の1例 Peer-reviewed

藤岡俊亮, 吉田清香, 檜森紀子, 竹下孝之, 野呂充, 中澤徹

眼科臨床紀要　13　(2)　100-104　2020/02
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice. International-journal Peer-reviewed

Yoichi Wada, Atsuo Kikuchi, Akimune Kaga, Naoki Shimizu, Junya Ito, Ryo Onuma, Fumiyoshi Fujishima, Eriko Totsune, Ryo Sato, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Kota Sato, Toru Nakazawa, Keiko Nakayama, Yoko Aoki, Setsuya Aiba, Kiyotaka Nakagawa, Shigeo Kure

PLoS genetics　16　(2)　e1008628　2020/02

DOI： 10.1371/journal.pgen.1008628 　

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Skin lesions, cataracts, and congenital anomalies have been frequently associated with inherited deficiencies in enzymes that synthesize cholesterol. Lanosterol synthase (LSS) converts (S)-2,3-epoxysqualene to lanosterol in the cholesterol biosynthesis pathway. Biallelic mutations in LSS have been reported in families with congenital cataracts and, very recently, have been reported in cases of hypotrichosis. However, it remains to be clarified whether these phenotypes are caused by LSS enzymatic deficiencies in each tissue, and disruption of LSS enzymatic activity in vivo has not yet been validated. We identified two patients with novel biallelic LSS mutations who exhibited congenital hypotrichosis and midline anomalies but did not have cataracts. We showed that the blockade of the LSS enzyme reaction occurred in the patients by measuring the (S)-2,3-epoxysqualene/lanosterol ratio in the forehead sebum, which would be a good biomarker for the diagnosis of LSS deficiency. Epidermis-specific Lss knockout mice showed neonatal lethality due to dehydration, indicating that LSS could be involved in skin barrier integrity. Tamoxifen-induced knockout of Lss in the epidermis caused hypotrichosis in adult mice. Lens-specific Lss knockout mice had cataracts. These results confirmed that LSS deficiency causes hypotrichosis and cataracts due to loss-of-function mutations in LSS in each tissue. These mouse models will lead to the elucidation of the pathophysiological mechanisms associated with disrupted LSS and to the development of therapeutic treatments for LSS deficiency.
The Sustained Release of Tafluprost with a Drug Delivery System Prevents the Axonal Injury-induced Loss of Retinal Ganglion Cells in Rats. International-journal Peer-reviewed

Kota Sato, Yurika Nakagawa, Kazuko Omodaka, Hiroyuki Asada, Shinobu Fujii, Kenji Masaki, Toru Nakazawa

Current eye research　1-10　2020/01/29

DOI： 10.1080/02713683.2020.1715446 　

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Purpose: To investigated whether a new drug delivery system (DDS) could enable the controlled release of tafluprost and suppress retinal ganglion cell (RGC) death in rats after optic nerve transection (ONT).Methods: A DDS containing 0.04%, 0.20% or 1.00% tafluprost, or vehicle, was injected intravitreally in 8-12-week-old male Sprague-Dawley rats 7 days before ONT, and the retinas were extracted 7 days after ONT. For comparison, eye drops containing 0.0015% tafluprost or vehicle were used once a day. The extracted retinas were analyzed with liquid chromatography-tandem mass spectrometry, immunohistochemistry and western blotting.Results: The level of tafluprost acid in the groups that received the 0.20% and 1.00% tafluprost DDSs was stable, and higher than the maximum concentration in the eye drop group, even after 14 days. In the retinas treated with the 1.00% tafluprost DDS, the active form of the drug had a high concentration (~50 times higher than eye drops), but no significant IOP difference compared with its vehicle in this study. The 1.00% tafluprost DDS group also had less cleaved α-fodrin and fewer c-Jun-positive cells than the vehicle DDS group.Conclusions: This study found that a newly developed DDS allowed the controlled release of tafluprost and prevented the loss of RGCs after ONT IOP independently. The duration of drug action on the target site was longer with a tafluprost DDS than with topical instillation and should therefore reduce problems related to lack of patient compliance. This system may also enable new treatments to prevent RGC degeneration in diseases such as glaucoma.
Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice. International-journal Peer-reviewed

Koji M Nishiguchi, Kosuke Fujita, Fuyuki Miya, Shota Katayama, Toru Nakazawa

Nature communications　11　(1)　482-482　2020/01/24

DOI： 10.1038/s41467-019-14181-3 　

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Supplementing wildtype copies of functionally defective genes with adeno-associated virus (AAV) is a strategy being explored clinically for various retinal dystrophies. However, the low cargo limit of this vector allows its use in only a fraction of patients with mutations in relatively small pathogenic genes. To overcome this issue, we developed a single AAV platform that allows local replacement of a mutated sequence with its wildtype counterpart, based on combined CRISPR-Cas9 and micro-homology-mediated end-joining (MMEJ). In blind mice, the mutation replacement rescued approximately 10% of photoreceptors, resulting in an improvement in light sensitivity and an increase in visual acuity. These effects were comparable to restoration mediated by gene supplementation, which targets a greater number of photoreceptors. This strategy may be applied for the treatment of inherited disorders caused by mutations in larger genes, for which conventional gene supplementation therapy is not currently feasible.
MEMS-based wearable eyeglasses for eye health monitoring

Neelam Kaushik, Takashi Sasaki, Yoshiki Takahashi, Toru Nakazawa, Kazuhiro Hane

Biomedical Physics and Engineering Express　6　(1)　2020

DOI： 10.1088/2057-1976/ab562e 　

eISSN： 2057-1976
Rapid Administration of High-Dose Intravenous Methylprednisolone Improves Visual Outcomes After Optic Neuritis in Patients With AQP4-IgG-Positive NMOSD. International-journal

Tetsuya Akaishi, Takayuki Takeshita, Noriko Himori, Toshiyuki Takahashi, Tatsuro Misu, Ryo Ogawa, Kimihiko Kaneko, Juichi Fujimori, Michiaki Abe, Tadashi Ishii, Kazuo Fujihara, Masashi Aoki, Toru Nakazawa, Ichiro Nakashima

Frontiers in neurology　11　932-932　2020

DOI： 10.3389/fneur.2020.00932 　

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Objective: The purpose of this study was to elucidate the rapid impact of high-dose intravenous methylprednisolone pulse therapy (1,000 mg/day for 3 days) on the eventual visual prognosis in patients with serum anti-aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSDs) who had an attack of optic neuritis (ON). Methods: Data from 32 consecutive NMOSD patients (1 male and 31 female) with at least one ON attack, involving a total of 36 ON-involved eyes, were evaluated. The following variables at ON onset were evaluated: sex, age at the first ON episode, visual acuity at nadir, visual acuity after 1 year, duration from ON onset to treatment for an acute ON attack, cycles of high-dose intravenous methylprednisolone pulse therapy for the ON attack, and cycles of plasmapheresis for the ON attack. Among the 36 ON-involved eyes, 27 eyes were studied using orbital MRI with a short-T1 inversion recovery sequence and gadolinium-enhanced fat-suppressed T1 imaging before starting treatment in the acute phase. Results: In univariate analyses, a shorter duration from ON onset to the initiation of high-dose intravenous methylprednisolone pulse therapy favorably affected the eventual visual prognosis 1 year later (Spearman's rho = 0.50, p = 0.0018). The lesion length on orbital MRI was also correlated with the eventual visual prognosis (rho = 0.68, p < 0.0001). Meanwhile, the days to steroid pulse therapy and lesion length on orbital MRI did not show a significant correlation. These findings suggest that the rapidness of steroid pulse therapy administration affects the eventual visual prognosis independent of the severity of ON. In multivariate analysis, a shorter time from ON onset to the start of acute treatment (p = 0.0004) and a younger age at onset (p = 0.0071) were significantly associated with better visual outcomes. Conclusions: Rapid initiation of high-dose intravenous methylprednisolone pulse therapy is essential to preserve the eventual visual acuity in patients with serum AQP4-IgG-positive NMOSD. Once clinicians suspect acute ON with serum AQP4-IgG, swift administration of steroid pulse therapy before confirming the positivity of serum AQP4-IgG would be beneficial for preserving visual function.
Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion. International-journal

Masayuki Yasuda, Hajime Sato, Kazuki Hashimoto, Urara Osada, Takehiro Hariya, Hiroko Nakayama, Toshifumi Asano, Noriyuki Suzuki, Tatsu Okabe, Mai Yamazaki, Megumi Uematsu, Masanori Munakata, Toru Nakazawa

PloS one　15　(10)　e0240977　2020

DOI： 10.1371/journal.pone.0240977 　

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PURPOSE: To investigate factors associated with poor visual acuity (VA) in branch retinal artery occlusion (BRAO). METHODS: This was a retrospective cross-sectional study of 72 eyes with BRAO of 72 patients. For statistical comparison, we divided the patients into worse-VA (decimal VA < 0.5) and better-VA (decimal VA > = 0.5) groups. We examined the association of clinical findings, including blood biochemical test data and carotid artery ultrasound parameters, with poor VA. RESULTS: Median age, hematocrit, hemoglobin and high-density lipoprotein (HDL) differed significantly between the groups (P = 0.018, P < 0.01, P < 0.01, and P = 0.025). There was a tendency towards higher median IMT-Bmax in the worse-VA group (worse-VA vs. better-VA: 2.70 mm vs. 1.60 mm, P = 0.152). Spearman's rank correlation test revealed that logMAR VA was significantly correlated to IMT-Bmax (rs = 0.31, P < 0.01) and IMT-Cmax (rs = 0.24, P = 0.035). Furthermore, logMAR VA was significantly correlated to HDL level (rs = -0.33, P < 0.01). Multivariate logistic regression analysis revealed that IMT-Bmax (odds ratio [OR] = 2.70, P = 0.049), HDL level (OR = 0.91, P = 0.032), and female gender (OR = 15.63, P = 0.032) were independently associated with worse VA in BRAO. CONCLUSIONS: We found that increased IMT-Bmax, decreased HDL, and female sex were associated with poor VA in BRAO patients. Our findings might suggest novel risk factors for visual dysfunction in BRAO and may provide new insights into the pathomechanisms underlying BRAO.
大学病院へ紹介された感染性角膜炎疑い症例における全身投与抗菌薬の使用状況の調査 Peer-reviewed

吉田真彰, 横倉俊二, 望月清文, 戸所大輔, 針谷威寛, 小林航, 小澤憲司, 齊藤千真, 中澤徹

日本眼科学会雑誌　124　(1)　21-23　2020/01
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study. Peer-reviewed

Kim YW, Kim YJ, Cheong HS, Shiga Y, Hashimoto K, Song YJ, Kim SH, Choi HJ, Nishiguchi KM, Kawai Y, Nagasaki M, Nakazawa T, Park KH, Kim DM, Jeoung JW

Scientific reports　10　(1)　221　2020/01

DOI： 10.1038/s41598-019-57066-7 　
The association between oxidative stress and corneal hysteresis in patients with glaucoma. International-journal Peer-reviewed

Uchida K, Himori N, Hashimoto K, Shiga Y, Tsuda S, Omodaka K, Nakazawa T

Scientific reports　10　(1)　545-545　2020/01

DOI： 10.1038/s41598-020-57520-x 　

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Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a free radical analyzer to measure BAP, and an ocular response analyzer to measure CH and corneal resistance factor (CRF). We evaluated the relationship between systemic oxidative stress and other clinical parameters with Spearman's rank correlation test and a multi-regression analysis. BAP was not correlated to either CH or CRF in the male or female OAG patients. BAP was correlated to both CH and CRF in the female OAG patients older than 57 years (r = 0.51, P = 0.003; r = 0.49, P = 0.004), but uncorrelated in the female OAG patients younger than 57 years. Multiple regression analysis revealed that BAP independently contributed to CH (P = 0.025) and CRF (P = 0.015) in the older female OAG patients. Systemic oxidative stress may significantly affect the viscoelasticity of the cornea in older female OAG patients. Future studies are needed to confirm that low systemic antioxidative status and low corneal hysteresis contribute to glaucoma pathogenesis.
In vivo and in vitro knockout system labelled using fluorescent protein via microhomology-mediated end joining. Peer-reviewed

Katayama S, Sato K, Nakazawa T

Life science alliance　3　(1)　2020/01

DOI： 10.26508/lsa.201900528 　
Progression from Classical Oguchi Disease to Retinitis Pigmentosa after 50 Years. Peer-reviewed

Nishiguchi KM, Oguchi Y, Nakazawa T

Ophthalmology　127　(1)　51　2020/01

DOI： 10.1016/j.ophtha.2019.09.015 　

ISSN： 0161-6420
The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery. International-journal Peer-reviewed

Kotaro Yamamoto, Taiki Kokubun, Kota Sato, Takahiro Akaishi, Atsushi Shimazaki, Masatsugu Nakamura, Yukihiro Shiga, Satoru Tsuda, Kazuko Omodaka, Hideyuki Saya, Toru Nakazawa

Scientific reports　9　(1)　19288-19288　2019/12/17

DOI： 10.1038/s41598-019-55365-7 　

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Treatments for refractory glaucoma include trabeculectomy, in which a filtering bleb is created to reduce aqueous pressure. Mitomycin C (MMC) is often used as an adjuvant to reduce post-trabeculectomy bleb scarring and consequent failure. However, scarring sometimes still occurs. Thus, we searched for more effective trabeculectomy adjuvants with high-throughput screening (HTS) of a library of 1,165 off-patent drug compounds. This revealed that amsacrine (AMSA), a DNA topoisomerase II (TOP2) inhibitor, was the top candidate. Compared to MMC, rabbits that underwent trabeculectomy with 10% AMSA had lower IOP at 42, 56, and 70 days (P < 0.01 at all measurement points) and a higher bleb score at 28, 42, 56, and 70 days (P = < 0.01, 0.04, 0.04, and < 0.01, respectively). Compared to saline, rabbits that received 1% AMSA also had lower IOP and better bleb score at all time points, without a sharp drop in IOP just after surgery (all P < 0.01). Both effects were milder than MMC at 7 days (P = 0.02 and <0.01, respectively). Thus, this study showed that HTS may help identify new, promising uses for off-patent drugs. Furthermore, trabeculectomy with AMSA at a suitable concentration may improve the prognosis after trabeculectomy compared to MMC.
東北大学における眼窩先端部症候群19例の検討 Peer-reviewed

二宮高洋, 檜森紀子, 吉田清香, 三島史子, 竹下孝之, 中澤徹

神経眼科　36　(4)　404-409　2019/12
Publisher: 日本神経眼科学会
ISSN： 0289-7024

eISSN： 2188-2002
CPAP therapy reduces oxidative stress in patients with glaucoma and OSAS and improves the visual field. International-journal Peer-reviewed

Himori N, Ogawa H, Ichinose M, Nakazawa T

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　258　(4)　939-941　2019/12

DOI： 10.1007/s00417-019-04483-z 　

ISSN： 0721-832X
Phenotypic Features of Oguchi Disease and Retinitis Pigmentosa in Patients with S-Antigen Mutations: A Long-Term Follow-up Study. International-journal Peer-reviewed

Koji M Nishiguchi, Yasuhiro Ikeda, Kosuke Fujita, Hiroshi Kunikata, Makoto Akiho, Kazuki Hashimoto, Katsuhiro Hosono, Kentaro Kurata, Yoshito Koyanagi, Masato Akiyama, Takefumi Suzuki, Ryo Kawasaki, Yuko Wada, Yoshihiro Hotta, Koh-Hei Sonoda, Akira Murakami, Mitsuru Nakazawa, Toru Nakazawa, Toshiaki Abe

Ophthalmology　126　(11)　1557-1566　2019/11

DOI： 10.1016/j.ophtha.2019.05.027 　

ISSN： 0161-6420

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PURPOSE: To present phenotypic features of 22 patients with S-antigen (SAG) mutations. DESIGN: Retrospective cohort study. PARTICIPANTS: Twenty-one Japanese patients from 16 families with a homozygous c.924delA mutation and 1 patient with a homozygous c.636delT mutation in the SAG gene. METHODS: Clinical records on symptoms; best-corrected visual acuity; and Goldmann perimetry, fundus photography, fundus autofluorescence (FAF), OCT, and electroretinography results were reviewed. MAIN OUTCOME MEASURES: Best-corrected visual acuity, Goldmann perimetry results, imaging findings, and electroretinography results. RESULTS: Ten patients had Oguchi disease and 12 had retinitis pigmentosa (RP) with mean follow-up periods of 13.8 and 10.2 years, respectively. Retinitis pigmentosa patients were older (mean age, 56.0 years) than those with Oguchi disease (mean age, 22.1 years; P < 0.001) at the initial visit. Night blindness noted in childhood was the most common initial symptom for both Oguchi disease (80.0%) and RP (91.7%) patients. Best-corrected visual acuity in the logarithm of the minimum angle of resolution (logMAR) was well preserved in Oguchi disease patients (mean, 0.02 logMAR in both eyes) but reduced in most RP patients (mean, 1.32 logMAR [right eye] and 1.35 logMAR [left eye]). Similarly, the visual field in the retinal area was preserved in Oguchi disease patients (mean, 677 mm2 right eye and 667 mm2 left eye) and reduced in RP patients (mean, 369 mm2 right eye and 294 mm2 left eye). Fundus images revealed a characteristic golden sheen with no retinal degeneration in Oguchi disease patients, excluding 2 with macular degeneration detected by FAF, OCT, or both and 1 with mild retinal degeneration confirmed by OCT and fluorescein angiography. Pigmentary retinal degeneration most evident posteriorly was observed in RP patients, accompanied by a characteristic golden sheen in 12 of 14 patients undergoing ultra-widefield fundus imaging. OCT showed disrupted macular structure, and FAF revealed variable hypofluorescence. Electroretinography identified absent rod responses in both diseases, along with relative preservation of cone responses in Oguchi disease patients. Three patients showed progressive loss of the golden sheen based on fundus images, including 1 who demonstrated RP 26 years after the initial diagnosis of Oguchi disease. CONCLUSIONS: Retinitis pigmentosa with SAG mutations often shows a characteristic golden sheen surrounding posterior pigmentary retinal degeneration. Oguchi disease can show progressive degeneration in adulthood, rarely resulting in RP.
Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images. International-journal Peer-reviewed

Yasuko Tatewaki, Tatsushi Mutoh, Kazuko Omodaka, Benjamin Thyreau, Izumi Matsudaira, Hiroaki Furukawa, Keiji Yamada, Keiko Kunitoki, Ryuta Kawashima, Toru Nakazawa, Yasuyuki Taki

Scientific reports　9　(1)　15148-15148　2019/10/22

DOI： 10.1038/s41598-019-51611-0 　

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Elongated axial length of the eye increases the morbidity of glaucoma. Myopia also associates with elongated axial length, and such ellipsoid shape of the eyeball strongly contributes its pathogenesis. Morphological features of the eyeballs, which could be important factors for developing glaucoma, have not been well described. The aim of this study was to investigate the three-dimensional (3D) topographic features of glaucomatous eyeballs with/without myopia to evaluate the potential of those features for predicting glaucoma. Using a 3.0-tesla MRI, volume-isotropic turbo-spin-echo acquisition T2-weighted images were obtained from 55 patients with glaucoma and 22 controls to delineate the eyeballs. Eyeball volumes, axial lengths and transverse lengths were semi-automatically calculated and compared between four groups: normal, myopia, glaucoma, and glaucoma with myopia. Both glaucoma and myopia increased the eyeball volume compared to the normal eyes. An increased anisotropy ratio (axial/transversus length) was observed in myopic eyes compared to normal, whereas in the glaucomatous eyes, with or without myopia, no increase in anisotropy ratio was observed. Increasing volume of eyes can be caused by myopia and glaucoma. Myopic eyes were ellipsoid in shape, but there was less anisotropy and a near-spherical shape in glaucomatous eyes, even in glaucomatous myopic eyes.
Cyclin-Dependent Kinase Inhibitor 2b Mediates Excitotoxicity-Induced Death of Retinal Ganglion Cells

Hiroshi Tawarayama, Qiwei Feng, Namie Murayama, Noriyuki Suzuki, Toru Nakazawa

Investigative Opthalmology & Visual Science　60　(13)　4479-4479　2019/10/01
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
DOI： 10.1167/iovs.19-27396 　

ISSN： 1552-5783
Cyclin-Dependent Kinase Inhibitor 2b Attenuates Excitotoxicity-Induced Death of Retinal Ganglion Cells. Peer-reviewed

Tawarayama H, Feng Q, Murayama N, Suzuki N, Nakazawa T

Investigative ophthalmology & visual science　60　(13)　4479-4488　2019/10

DOI： 10.1167/iovs.19-27396 　

ISSN： 0146-0404
In vivo imaging of the light response in mouse retinal ganglion cells based on a neuronal activity-dependent promoter Peer-reviewed

Kosuke Fujita, Koji M Nishiguchi, Kota Sato, Yurika Nakagawa, Toru Nakazawa

Biochemical and Biophysical Research Communications　521　(2)　471-477　2019/10

DOI： 10.1016/j.bbrc.2019.10.155 　

ISSN： 0006-291X
Bilateral Necrotizing Herpes Simplex Keratitis in an Immunocompetent Patient With Genetic Analysis of Herpes Simplex Virus 1

Masaaki Yoshida, Mayumi Hosogai, Shunji Yokokura, Kota Sato, Takehiro Hariya, Wataru Kobayashi, Tatsu Okabe, Daisuke Todokoro, Toru Nakazawa

Cornea　38　(9)　1185-1188　2019/09/01
Publisher: NLM (Medline)
DOI： 10.1097/ICO.0000000000002026 　

ISSN： 1536-4798
Identification of novel biomarkers of hepatocellular carcinoma by a high definition mass spectrometry; UHPLC-QTOF/MS and DESI-MSI. Peer-reviewed

Nagai K, Uranbileg B, Chen Z, Fujioka A, Yamazaki T, Matsmoto Y, Tsukamoto H, Ikeda H, Yatomi Y, Chiba H, Hui SP, Nakazawa T, Saito R, Koshiba S, Aoki J, Saigusa D, Tomioka Y

Rapid communications in mass spectrometry : RCM　34　2019/08

DOI： 10.1002/rcm.8551 　

ISSN： 0951-4198

eISSN： 1097-0231
Retinal Thickness Analysis in High Myopia based on Medial Axis Transforms. International-journal Peer-reviewed

Takashi Michikawa, Satoshi Wada, Hideo Yokota, Guangzhou An, Masahiro Akiba, Kazuko Omodaka, Toru Nakazawa

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　2019　2805-2808　2019/07
Publisher: IEEE
DOI： 10.1109/EMBC.2019.8857091 　

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This paper presents a retinal thickness analysis method from 3D images acquired by optical coherence tomography (OCT). Given OCT images with segmented boundaries of retinal layers, medial axes of the layers are computed by medial axis transforms (MAT), and thickness is evaluated based on Euclidean distance fields. Since the MAT computes the closest points on the boundary of the layer, it can compute more correct thickness than conventional methods that evaluate Y-axis-aligned thickness. Experimental results show that our method can detect thin-parts around distorted regions, or a clue of high myopia. This is useful for early diagnosis of high myopia and other eye diseases.
Historical, Current and Future Approaches to Surgery for Rhegmatogenous Retinal Detachment. Peer-reviewed

Hiroshi Kunikata, Toshiaki Abe, Toru Nakazawa

The Tohoku journal of experimental medicine　248　(3)　159-168　2019/07

DOI： 10.1620/tjem.248.159 　

ISSN： 0040-8727

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Rhegmatogenous retinal detachment (RRD) is a serious condition that can cause blindness without surgical treatment. RRD occurs when a retinal tear or hole allows fluid to accumulate below the retinal surface, causing the retina to separate from the underlying layers. RRD is difficult to treat because each case is unique, varying with the location, size, and duration of the detachment, as well as patient age. The first successful methods to reattach the retina in RRD used thermocautery to repair the detachment. Many renowned ophthalmologists continued to study RRD and developed many new surgical approaches, notably: scleral buckling (SB), in which a silicone band is placed around the eye to reduce traction on the retina caused by the vitreous humor that fills the eye; pars plana vitrectomy (PPV), which eliminates traction on the retina by removing the vitreous; and pneumatic retinopexy (PR), in which the retina is reattached by pushing it back into place with an expanding gas bubble injected into the eye. However, no consensus has been reached on which approach is ideal. Furthermore, recent surgical and non-surgical breakthroughs, such as artificial vitreous substitutes and neuroprotective drugs, must also be considered. Thus, this review provides a guide for ocular specialists and non-specialists on the historical background of RRD, summarizes the three current main techniques (SB, PR and PPV) compares these three techniques, and provides an overview of new technologies that promise to greatly improve outcomes after RRD surgery.
Assessing retinal ganglion cell death and neuroprotective agents using real time imaging. International-journal Peer-reviewed

Azusa Ito, Satoru Tsuda, Hiroshi Kunikata, Asano Toshifumi, Kota Sato, Toru Nakazawa

Brain research　1714　65-72　2019/07/01

DOI： 10.1016/j.brainres.2019.02.008 　

ISSN： 0006-8993

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The evaluation of retinal ganglion cell (RGC) death is a key part of retinal disease care. Previously, we used a Sytox Orange (SO)-based real-time imaging method to assess the RGCs in mice that underwent optic nerve crush. Here, we used N-methyl-D-aspartate (NMDA) injury in rats to confirm our model and assess the effect of neuroprotective agents on RGCs. The rats received NMDA injury and the intravitreal injection of SO, a cell-impermeant dyeing compound that targets nucleic acid. After ten minutes, non-invasive confocal scanning laser ophthalmoscopy visualized damaged or dying cells. Finally, the retinas were flat-mounted for histological confirmation of RGC death, with retrograde Fluorogold labeling and Alexa Fluor 488 Annexin V-conjugate (Annexin V) staining. This also revealed the time course of retinal cell death and the neuroprotective effect of SNJ-1945. Real-time imaging showed that SO-positive cells significantly increased starting 2 h after NMDA injection and reached an approximate plateau at 3 h. SO-positive cells were positive for Fluorogold and Annexin V in the isolated retinas. Moreover, the number of SO-positive retinal cells was significantly lower after treatment with SNJ-1945, compared to carboxymethyl cellulose. These results were confirmed in the isolated retinas. Thus, real-time imaging with SO allows the quick quantification of NMDA-induced RGC damage and death, and evaluation of neuroprotective agents. This technique may aid research into the development of new neuroprotective therapies.
Diagnostic power of laser speckle flowgraphy-measured optic disc microcirculation for open-angle glaucoma: Analysis of 314 eyes. International-journal Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Toru Nakazawa

Clinical & experimental ophthalmology　47　(5)　680-683　2019/07

DOI： 10.1111/ceo.13482 　

ISSN： 1442-6404
Quantitative analysis of the macula with optical coherence tomography angiography in normal Japanese subjects: The Taiwa Study. International-journal Peer-reviewed

Risa Sato, Hiroshi Kunikata, Toshifumi Asano, Naoko Aizawa, Naoki Kiyota, Yukihiro Shiga, Koji M Nishiguchi, Keiichi Kato, Toru Nakazawa

Scientific reports　9　(1)　8875-8875　2019/06/20

DOI： 10.1038/s41598-019-45336-3 　

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This study evaluated age-related changes in the superficial and deep retinal capillary plexus (SCP and DCP, respectively) and in the foveal avascular zone (FAZ). SCP and DCP perfusion density (PD) were measured in optical coherence tomography angiography (OCTA) macular scans of 145 eyes of 145 healthy Japanese subjects, and findings were compared with SCP FAZ and clinical data. We found that age was negatively correlated with SCP and DCP PD (r = -0.17, P = 0.04 and r = -0.20, P = 0.02, respectively) and positively correlated with FAZ area (r = 0.18, P = 0.03). SCP and DCP PD were correlated with each other (r = 0.67, P < 0.001). FAZ area was negatively correlated with SCP PD, DCP PD and central macular thickness (CMT) (r = -0.18, P = 0.03; r = -0.25, P < 0.01; and r = -0.39, P < 0.001, respectively). FAZ was larger and CMT was lower (P = 0.01 and P < 0.001, respectively) in women than men. SCP and DCP PD were positively correlated with estimated glomerular filtration rate (r = 0.17, P = 0.03 and r = 0.24, P < 0.01, respectively). Multiple regression analysis confirmed that age independently affected DCP PD and FAZ (P = 0.02 and P < 0.01, respectively) and that CMT independently affected FAZ area (P < 0.001). Thus, normal subjects showed age-related decreases in macular PD and renal function. FAZ and CMT were related, suggesting that age-related changes in macular thickness also affect capillary vasculature.
Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression. International-journal Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

Investigative ophthalmology & visual science　60　(7)　2650-2658　2019/06/03

DOI： 10.1167/iovs.19-27230 　

ISSN： 0146-0404

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Purpose: To investigate sectoral differences in the relationship between optic nerve head tissue blood flow, anatomically corresponding visual field defect severity, and future progression. Methods: This retrospective longitudinal medical chart review comprised 508 eyes of 319 open-angle glaucoma patients (mean deviation: -9.2 ± 7.0 dB), followed for an average of 4.7 ± 1.1 years; an average 11.7 ± 3.7 visual field tests were performed. Average total deviation (TD) was calculated in the superior, central, and inferior sectors of the Humphrey 24-2 program. The optic nerve head was divided to obtain inferior, temporal, and superior tissue-area mean blur rate (MT), derived from laser speckle flowgraphy. At baseline, the correlation between MT and TD was compared in anatomically corresponding sectors. We performed a multivariate analysis to determine the contribution of baseline MT to corresponding TD slope and to determine background factors influencing superior to temporal MT. We used a linear-mixed effect model for the statistical analysis. Results: At baseline, the highest β coefficients were found between MT-superior and TD-inferior, MT-temporal and TD-central, and between MT-inferior and TD-superior, in that order (β = 0.38, β = 0.27, β = 0.26, respectively). MT-superior and MT-temporal independently contributed to corresponding TD slope (P < 0.05). Male sex, high body mass index, and the prevalence of sleep apnea syndrome were contributing factors to lower superior to temporal MT (P < 0.05). Conclusions: Review of medical history, measurements of systemic variables, and laser speckle flowgraphy parameters might help clinicians to predict visual field defect severity and progression.
Transscleral sustained ranibizumab delivery using an episcleral implantable device: Suppression of laser-induced choroidal neovascularization in rats. International-journal Peer-reviewed

Nagai N, Nezhad ZK, Daigaku R, Saijo S, Song Y, Terata K, Hoshi A, Nishizawa M, Nakazawa T, Kaji H, Abe T

International journal of pharmaceutics　567　118458-118458　2019/06

DOI： 10.1016/j.ijpharm.2019.118458 　

ISSN： 0378-5173

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Successful treatment of age-related macular diseases requires an effective controlled drug release system with less invasive route of administration in the eye to reduce the burden of frequent intravitreal injections for patients. In this study, we developed an episcleral implantable device for sustained release of ranibizumab, and evaluated its efficacy on suppression of laser-induced choroidal neovascularization (CNV) in rats. We tested both biodegradable and non-biodegradable sheet-type devices consisting of crosslinked gelatin/chitosan (Gel/CS) and photopolymerized poly(ethyleneglycol) dimethacrylate that incorporated collagen microparticles (PEGDM/COL). In vitro release studies of FITC-labeled albumin showed a constant release from PEGDM/COL sheets compared to Gel/CS sheets. The Gel/CS sheets gradually biodegraded in the sclera during the 24-week implantation; however, the PEGDM/COL sheets did not degrade. FITC-albumin was detected in the retina during 18 weeks implantation in the PEGDM/COL sheet-treated group, and was detected in the Gel/CS sheet-treated group during 6 weeks implantation. CNV was suppressed 18 weeks after application of ranibizumab-loaded PEGDM/COL sheets compared to a placebo PEGDM/COL sheet-treated group, and to the intravitreal ranibizumab-injected group. In conclusion, the PEGDM/COL sheet device suppressed CNV via a transscleral administration route for 18 weeks, indicating that prolonged sustained ranibizumab release could reduce the burden of repeated intravitreal injections.
A frequent variant in the Japanese population determines quasi-Mendelian inheritance of rare retinal ciliopathy. International-journal Peer-reviewed

Nikopoulos K, Cisarova K, Quinodoz M, Koskiniemi-Kuendig H, Miyake N, Farinelli P, Rehman AU, Khan MI, Prunotto A, Akiyama M, Kamatani Y, Terao C, Miya F, Ikeda Y, Ueno S, Fuse N, Murakami A, Wada Y, Terasaki H, Sonoda KH, Ishibashi T, Kubo M, Cremers FPM, Kutalik Z, Matsumoto N, Nishiguchi KM, Nakazawa T, Rivolta C

Nature communications　10　(1)　2884-2884　2019/06

DOI： 10.1038/s41467-019-10746-4 　

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Hereditary retinal degenerations (HRDs) are Mendelian diseases characterized by progressive blindness and caused by ultra-rare mutations. In a genomic screen of 331 unrelated Japanese patients, we identify a disruptive Alu insertion and a nonsense variant (p.Arg1933*) in the ciliary gene RP1, neither of which are rare alleles in Japan. p.Arg1933* is almost polymorphic (frequency = 0.6%, amongst 12,000 individuals), does not cause disease in homozygosis or heterozygosis, and yet is significantly enriched in HRD patients (frequency = 2.1%, i.e., a 3.5-fold enrichment; p-value = 9.2 × 10-5). Familial co-segregation and association analyses show that p.Arg1933* can act as a Mendelian mutation in trans with the Alu insertion, but might also associate with disease in combination with two alleles in the EYS gene in a non-Mendelian pattern of heredity. Our results suggest that rare conditions such as HRDs can be paradoxically determined by relatively common variants, following a quasi-Mendelian model linking monogenic and complex inheritance.
Bilateral Necrotizing Herpes Simplex Keratitis in an Immunocompetent Patient With Genetic Analysis of Human Simplex Virus 1. International-journal Peer-reviewed

Yoshida M, Hosogai M, Yokokura S, Sato K, Hariya T, Kobayashi W, Okabe T, Todokoro D, Nakazawa T

Cornea　38　(9)　1185-1188　2019/06

DOI： 10.1097/ICO.0000000000002026 　

ISSN： 0277-3740

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PURPOSE: To report a case of severe bilateral necrotizing herpes simplex keratitis (HSK) in an immunocompetent patient, with genotyping of the underlying herpes simplex virus 1 (HSV-1). METHODS: Genetic analyses of HSV-1 in tear samples were performed with polymerase chain reaction-based restriction fragment length polymorphism, targeting the viral genes unique short (US)2, US4 (glycoprotein G), and US7 (glycoprotein I). RESULTS: A 64-year-old woman with no history of atopy or immune disorders manifested bilateral keratitis with geographic ulcer. Her initial visual acuity was 20/1000 (OD) and 20/20 (OS). Polymerase chain reaction testing of a tear sample revealed the presence of HSV-1 in both eyes, and the patient was diagnosed with bilateral HSK. Both eyes progressed to necrotizing keratitis during the treatment course. Continuous intensive treatment, at first with acyclovir ointment and oral valacyclovir and later with steroid eye drops for stromal keratitis, finally improved the patient's condition. However, after 2 years, her visual acuity was limited to 20/250 (OD) and 20/60 (OS) because of corneal opacity from scarring. We found that the strain in the current case had a genotype combination of C/A/B (for US2/US4/US7), a known pattern in Japan, in both eyes. CONCLUSIONS: We successfully performed an unprecedented genetic analysis of an HSV-1 strain isolated from a case of bilateral necrotizing HSK in an immunocompetent patient. The association of the HSV-1 genotype with the clinical manifestation remains unclear, calling for more data from new cases, especially from different geographic regions.
Optical Coherence Tomography Assessment of Risk Factors for Visual Acuity Decline after Trabeculectomy in Patients with Advanced Open-angle Glaucoma. Peer-reviewed

Asaoka K, Kunimatsu-Sanuki S, Kokubun T, Nakazawa T

Journal of glaucoma　28　(9)　780-784　2019/06

DOI： 10.1097/IJG.0000000000001305 　

ISSN： 1057-0829
Effects of Brimonidine and Timolol on the Progression of Visual Field Defects in Open-angle Glaucoma: A Single-center Randomized Trial. International-journal Peer-reviewed

Yokoyama Y, Kawasaki R, Takahashi H, Maekawa S, Tsuda S, Omodaka K, Nakazawa T

Journal of glaucoma　28　(7)　575-583　2019/06

DOI： 10.1097/IJG.0000000000001285 　

ISSN： 1057-0829

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PRéCIS:: Instillation of brimonidine or timolol slowed visual field deterioration in patients with open-angle glaucoma; both brimonidine and timolol might improve the mean deviation (MD) slopes. PURPOSE: The purpose of this study was to investigate and compare the effects of 0.1% brimonidine and 0.5% timolol on the progressing visual field defects in open-angle glaucoma. PATIENTS AND METHODS: We evaluated 1 eye each of 68 glaucoma patients who were treated with at least 1 prostaglandin analog. Their baseline MD slopes were < -0.5 dB/y based on at least 5 Humphrey field analyzer measurements within 3 years. Eligible eyes were randomly assigned to brimonidine or timolol treatment groups and treatments were administered without the wash-out period. Clinical examinations were performed every 4 months for 2 years. We designated the MD slope as the primary endpoint. RESULTS: Ultimately, 56 eyes (brimonidine:timolol=26:30) were included in the present study (mean age=65.2 y). Dropout rates of brimonidine and timolol treatment groups were 27.8% and 6.3%, respectively. There were no significant differences in baseline intraocular pressure or MD slopes between brimonidine and timolol groups (12.7 and 12.9 mm Hg, P=0.77, and -1.22 and -1.08 dB/y, P=0.43, respectively). Intraocular pressure decreased significantly in the brimonidine group at 4, 8, 12, and 16 months, and in the timolol group at 4 months, without significant differences between the drugs (P=0.20). MD slopes significantly improved in both groups (brimonidine: -0.38 dB/y, P<0.001; timolol: -0.52 dB/y, P=0.04). Furthermore, there was no significant difference between groups in the primary endpoint (P=0.59). CONCLUSION: Brimonidine and timolol treatments improved MD slopes in open-angle glaucoma.
Genetic characteristics of retinitis pigmentosa in 1204 Japanese patients Peer-reviewed

Koyanagi, Yoshito Akiyama, Masato Nishiguchi, Koji M Momozawa, Yukihide Kamatani, Yoichiro Takata, Sadaaki Inai, Chihiro Iwasaki, Yusuke Kumano, Mikako Murakami, Yusuke Omodaka, Kazuko Abe, Toshiaki Komori, Shiori Gao, Dan Hirakata, Toshiaki Kurata, Kentaro Hosono, Katsuhiro Ueno, Shinji Hotta, Yoshihiro Murakami, Akira Terasaki, Hiroko Wada, Yuko Nakazawa, Toru Ishibashi, Tatsuro Ikeda, Yasuhiro Kubo, Michiaki Sonoda, Koh-Hei

Journal of Medical Genetics　56　(10)　662-670　2019/06
Publisher: BMJ
DOI： 10.1136/jmedgenet-2018-105691 　

ISSN： 0022-2593

eISSN： 1468-6244

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<sec><title>Background</title>The genetic profile of retinitis pigmentosa (RP) in East Asian populations has not been well characterised. Therefore, we conducted a large-scale sequencing study to investigate the genes and variants causing RP in a Japanese population. </sec><sec><title>Methods</title>A total of 1209 Japanese patients diagnosed with typical RP were enrolled. We performed deep resequencing of 83 known causative genes of RP using next-generation sequencing. We defined pathogenic variants as those that were putatively deleterious or registered as pathogenic in the Human Gene Mutation Database or ClinVar database and had a minor allele frequency in any ethnic population of ≤0.5% for recessive genes or ≤0.01% for dominant genes as determined using population-based databases. </sec><sec><title>Results</title>We successfully sequenced 1204 patients with RP and determined 200 pathogenic variants in 38 genes as the cause of RP in 356 patients (29.6%). Variants in six genes (<italic>EYS</italic>, <italic>USH2A</italic>, <italic>RP1L1</italic>, <italic>RHO</italic>, <italic>RP1</italic> and <italic>RPGR</italic>) caused RP in 65.4% (233/356) of those patients. Among autosomal recessive genes, two known founder variants in <italic>EYS</italic> [p.(Ser1653fs) and p.(Tyr2935*)] and four East Asian-specific variants [p.(Gly2752Arg) in <italic>USH2A</italic>, p.(Arg658*) in <italic>RP1L1</italic>, p.(Gly2186Glu) in <italic>EYS</italic> and p.(Ile535Asn) in <italic>PDE6B</italic>] and p.(Cys934Trp) in <italic>USH2A</italic> were found in ≥10 patients. Among autosomal dominant genes, four pathogenic variants [p.(Pro347Leu) in <italic>RHO</italic>, p.(Arg872fs) in <italic>RP1</italic>, p.(Arg41Trp) in <italic>CRX</italic> and p.(Gly381fs) in <italic>PRPF31</italic>] were found in ≥4 patients, while these variants were unreported or extremely rare in both East Asian and non-East Asian population-based databases. </sec><sec><title>Conclusions</title>East Asian-specific variants in causative genes were the major causes of RP in the Japanese population. </sec>
Evaluation of deep convolutional neural networks for glaucoma detection

Sang Phan, Shin’ichi Satoh, Yoshioki Yoda, Kenji Kashiwagi, Tetsuro Oshika, Takashi Hasegawa, Kenji Kashiwagi, Masahiro Miyake, Taiji Sakamoto, Takeshi Yoshitomi, Masaru Inatani, Tetsuya Yamamoto, Kazuhisa Sugiyama, Makoto Nakamura, Akitaka Tsujikawa, Chie Sotozono, Koh-Hei Sonoda, Hiroko Terasaki, Yuichiro Ogura, Takeo Fukuchi, Fumio Shiraga, Kohji Nishida, Toru Nakazawa, Makoto Aihara, Hidetoshi Yamashita, Iijima Hiyoyuki, The Japan Ocular Imaging Registry Research Group

Japanese Journal of Ophthalmology　63　(3)　276-283　2019/05/16
Publisher: Springer Tokyo
DOI： 10.1007/s10384-019-00659-6 　

ISSN： 1613-2246 0021-5155
Intraocular Concentrations of Cytokines and Chemokines in a Unique Case of Nivolumab-Induced Uveitis. International-journal Peer-reviewed

Masaaki Yoshida, Hiroshi Kunikata, Toru Nakazawa

Ocular immunology and inflammation　28　(6)　1-4　2019/04/23

DOI： 10.1080/09273948.2019.1582785 　

ISSN： 0927-3948

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PURPOSE: To report a unique case of nivolumab-induced uveitis and the results of a cytokine analysis of an intraocular fluid sample. CASE REPORT: A 61-year-old male patient undergoing treatment for renal cell carcinoma with nivolumab presented with bilateral uveitis. Severe anterior uveitis and vitreous opacity coincided with decreased visual acuity only in his left eye. Iris damage was present in this eye because of previous complicated cataract surgery. Vitrectomy was performed to remove the vitreous opacity, and visual acuity recovered postoperatively. A cytokine analysis of an intraocular fluid sample revealed a high level of interleukin-6, granulocyte-colony stimulating factor and interferon-inducible protein-10. CONCLUSION: This case indicates that nivolumab-induced uveitis might be more severe in eyes with a damaged iris, and that vitrectomy should be effective for vitreous opacity. A cytokine analysis of the ocular fluid indicated that multiple types of cell might be related to the inflammation process.
Correlation between aqueous flare and residual visual field area in retinitis pigmentosa. International-journal Peer-reviewed

Koji M Nishiguchi, Yu Yokoyama, Hiroshi Kunikata, Toshiaki Abe, Toru Nakazawa

The British journal of ophthalmology　103　(4)　475-480　2019/04

DOI： 10.1136/bjophthalmol-2018-312225 　

ISSN： 0007-1161

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BACKGROUND/AIMS: To investigate the relationship between aqueous flare, visual function and macular structures in retinitis pigmentosa (RP). METHODS: Clinical data from 123 patients with RP (227 eyes), 35 patients with macular dystrophy (68 eyes) and 148 controls (148 eyes) were analysed. The differences in aqueous flare between clinical entities and the correlation between aqueous flare (measured with a laser flare cell meter) versus visual acuity, visual field area (Goldmann perimetry) and macular thickness (optical coherence tomography) in patients with RP were determined. Influence of selected clinical data on flare was assessed using linear mixed-effects model. RESULTS: Aqueous flare was higher in patients with RP than patients with macular dystrophy or controls (p=7.49×E-13). Aqueous flare was correlated with visual field area (R=-0.379, p=3.72×E-9), but not with visual acuity (R=0.083, p=0.215). Macular thickness (R=0.234, p=3.74×E-4), but not foveal thickness (R=0.122, p=0.067), was positively correlated with flare. Flare was not affected by the presence of macular complications. All these associations were maintained when the right and the left eyes were assessed separately. Analysis by linear mixed-effects model revealed that age (p=8.58×E-5), visual field area (p=8.01×E-7) and average macular thickness (p=0.037) were correlated with flare. CONCLUSION: Aqueous flare and visual field area were correlated in patients with RP. Aqueous flare may reflect the degree of overall retinal degeneration more closely than the local foveal impairment.
Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene: Extending the RP1 Disease Spectrum. Peer-reviewed

Verbakel SK, van Huet RAC, den Hollander AI, Geerlings MJ, Kersten E, Klevering BJ, Klaver CCW, Plomp AS, Wesseling NL, Bergen AAB, Nikopoulos K, Rivolta C, Ikeda Y, Sonoda KH, Wada Y, Boon CJF, Nakazawa T, Hoyng CB, Nishiguchi KM

Investigative ophthalmology & visual science　60　(4)　1192-1203　2019/03

DOI： 10.1167/iovs.18-26084 　

ISSN： 0146-0404
The effectiveness of colchicine combined with mitomycin C to prolong bleb function in trabeculectomy in rabbits. International-journal Peer-reviewed

Kokubun T, Yamamoto K, Sato K, Akaishi T, Shimazaki A, Nakamura M, Shiga Y, Tsuda S, Omodaka K, Nakazawa T

PloS one　14　(3)　e0213811　2019/03

DOI： 10.1371/journal.pone.0213811 　

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PURPOSE: To investigate the potential of colchicine to improve bleb function after trabeculectomy. METHODS: To find the maximum usable colchicine concentration, an ocular irritation study was performed with the Draize test at concentrations of 0.001%, 0.01% and 0.1%. Additionally, the synergistic effect of topical colchicine instillation and MMC application to surgical site was evaluated in a rabbit model by measuring changes after trabeculectomy in intraocular pressure (IOP) and bleb morphology score at 3, 7, 14, 21, 28, 35, 42, and 49 days. RESULTS: Experiments with a rabbit model of trabeculectomy showed that 0.04% MMC plus 0.01% colchicine was more effective than saline and 0.04% MMC alone in maintaining IOP reduction at days 7-49 (P < 0.01 at all time points) and day 49 (P < 0.05), respectively, while 0.04% MMC alone was more effective than saline only at days 7-35 (P < 0.05 at all time points). 0.04% MMC plus 0.01% colchicine and 0.04% MMC alone were more effective than saline at preserving bleb score at days 7-21 and 35-49 (P < 0.05 at all time points) and at days 7-35 (P < 0.05 at all time points), respectively. CONCLUSION: Colchicine may be a promising adjuvant for strengthening the effect of MMC and improving the survival of the filtering bleb in trabeculectomy.
Macular degeneration as a common cause of visual loss in spinocerebellar ataxia type 1 (SCA1) patients. Peer-reviewed

Nishiguchi KM, Aoki M, Nakazawa T, Abe T

Ophthalmic genetics　40　(1)　49-53　2019/02

DOI： 10.1080/13816810.2019.1571614 　

ISSN： 1381-6810
Ninteen cases of orbital apex syndrome at tohoku university: A case series

Takahiro Ninomiya, Noriko Himori, Sayaka Yoshida, Fumiko Mishima, Takayuki Takeshita, Toru Nakazawa

Neuro-Ophthalmology Japan　36　(4)　404-409　2019
Publisher: Neuro-Ophthalmology Society of Japan
DOI： 10.11476/shinkeiganka.36.404 　

ISSN： 0289-7024
Efficacy of 27-Gauge Vitrectomy with Internal Limiting Membrane Peeling for Epiretinal Membrane in Glaucoma Patients. International-journal Peer-reviewed

Masaaki Yoshida, Hiroshi Kunikata, Shiho Kunimatsu-Sanuki, Toru Nakazawa

Journal of ophthalmology　2019　7807432-7807432　2019

DOI： 10.1155/2019/7807432 　

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Purpose: To evaluate the efficacy of epiretinal membrane (ERM) surgery for patients with ERM and glaucoma. Methods: We reviewed the medical records of 20 consecutive ERM patients with glaucoma, who underwent 27-gauge microincision vitrectomy surgery (27GMIVS) with internal limiting membrane (ILM) peeling. The preoperative and 6-month postoperative visual field was tested with the Humphrey Field Analyzer (HFA) 24-2 program. Changes in threshold sensitivity in the HFA test points were analyzed point-by-point, with points classified into groups based on sensitivity as abnormal (less than 5th percentile in pattern deviation) or normal (all other points) and based on location as central (12 central points) or peripheral (all other points) with a linear mixed-effects model. Results: Visual acuity and mean deviation improved postoperatively (P < 0.001 for both) in all patients. Threshold sensitivity in central or peripheral points that were abnormal preoperatively improved postoperatively (P=0.006 or P < 0.001, respectively). Threshold sensitivity also improved in the central normal test points (P=0.03), but not in the peripheral normal points (P=0.12). Conclusion: Visual acuity improved, and there was no visual field progression, after ERM surgery in glaucomatous eyes during a 6-month postoperative follow-up, suggesting that ERM and ILM removal using 27GMIVS may be effective even in glaucomatous eyes.
Color visual acuity in preperimetric glaucoma and open-angle glaucoma. International-journal Peer-reviewed

Junko Ouchi, Hiroshi Kunikata, Kazuko Omodaka, Haruka Sato, Hiroyuki Sato, Azusa Ito, Naoko Aizawa, Yoshiki Tanaka, Kazuo Ichikawa, Toru Nakazawa

PloS one　14　(4)　e0215290　2019

DOI： 10.1371/journal.pone.0215290 　

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PURPOSE: To investigate the clinical significance of color visual acuity (CVA) in preperimetric glaucoma (PPG) and open-angle glaucoma (OAG). METHODS: A total of 123 eyes of 73 subjects (22 normal eyes, 14 PPG eyes, and 87 OAG eyes; mean age: 44.9 ± 10.1 years, age range: 21-64 years) were enrolled. CVA was tested for red, green-yellow, blue-green and blue-purple with a newly developed test. RESULTS: There was no statistical difference in clinical background factors, including age, sex, intraocular pressure, or spherical equivalent between the three groups. Red VA and blue-green VA were significantly worse in the OAG eyes than in the normal eyes (P = 0.008 and P = 0.015, respectively), although green-yellow VA and blue-purple VA were not significantly worse. Furthermore, red VA and blue-green VA were significantly correlated with MD in a group of eyes with either PPG or OAG (r = -0.23, P = 0.023; r = -0.25, P = 0.012, respectively), but green-yellow VA and blue-purple VA were not. CONCLUSION: Red VA and blue-green VA were detectably worse in eyes with OAG, in close association with the degree of functional loss. This suggests that measuring CVA with the new color test described here may be a promising supplement to existing methods of detecting glaucoma and evaluating its severity.
Glaucoma Diagnosis with Machine Learning Based on Optical Coherence Tomography and Color Fundus Images. International-journal Peer-reviewed

An G, Omodaka K, Hashimoto K, Tsuda S, Shiga Y, Takada N, Kikawa T, Yokota H, Akiba M, Nakazawa T

Journal of healthcare engineering　2019　4061313-4061313　2019

DOI： 10.1155/2019/4061313 　

ISSN： 2040-2295

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This study aimed to develop a machine learning-based algorithm for glaucoma diagnosis in patients with open-angle glaucoma, based on three-dimensional optical coherence tomography (OCT) data and color fundus images. In this study, 208 glaucomatous and 149 healthy eyes were enrolled, and color fundus images and volumetric OCT data from the optic disc and macular area of these eyes were captured with a spectral-domain OCT (3D OCT-2000, Topcon). Thickness and deviation maps were created with a segmentation algorithm. Transfer learning of convolutional neural network (CNN) was used with the following types of input images: (1) fundus image of optic disc in grayscale format, (2) disc retinal nerve fiber layer (RNFL) thickness map, (3) macular ganglion cell complex (GCC) thickness map, (4) disc RNFL deviation map, and (5) macular GCC deviation map. Data augmentation and dropout were performed to train the CNN. For combining the results from each CNN model, a random forest (RF) was trained to classify the disc fundus images of healthy and glaucomatous eyes using feature vector representation of each input image, removing the second fully connected layer. The area under receiver operating characteristic curve (AUC) of a 10-fold cross validation (CV) was used to evaluate the models. The 10-fold CV AUCs of the CNNs were 0.940 for color fundus images, 0.942 for RNFL thickness maps, 0.944 for macular GCC thickness maps, 0.949 for disc RNFL deviation maps, and 0.952 for macular GCC deviation maps. The RF combining the five separate CNN models improved the 10-fold CV AUC to 0.963. Therefore, the machine learning system described here can accurately differentiate between healthy and glaucomatous subjects based on their extracted images from OCT data and color fundus images. This system should help to improve the diagnostic accuracy in glaucoma.
The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes. International-journal Peer-reviewed

Kohei Ichinohasama, Hiroshi Kunikata, Azusa Ito, Masayuki Yasuda, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Hideki Katagiri, Toru Nakazawa

Journal of ophthalmology　2019　3421305-3421305　2019

DOI： 10.1155/2019/3421305 　

ISSN： 2090-004X

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Purpose: To compare clinical findings, including ocular blood flow and intima-media thickness (IMT) of the carotid artery, in mild nonproliferative diabetic retinopathy (NPDR) and no diabetic retinopathy (NDR) patients, and to determine risk factors contributing to mild NPDR. Methods: In 129 subjects (129 eyes) with type-2 diabetes patients and mild NPDR or NDR, standard statistical techniques were used to determine associations between clinical findings, including diabetes duration, blood levels of creatinine and hemoglobin A1c (HbA1c), central macular thickness (CMT; measured with optical coherence tomography), mean blur rate (MBR; measured with laser speckle flowgraphy), and ultrasound-measured carotid IMT. Results: Diabetes duration, IMT, and CMT were significantly higher in the mild NPDR patients than the NDR patients (P=0.004, P=0.004, and P=0.003, respectively), while conversely, MBR in the overall optic nerve head (MBR-A) was lower in the mild NPDR patients. Furthermore, a logistic regression analysis showed that diabetes duration (OR, 1.11; P=0.006), diastolic blood pressure (OR, 0.93; P=0.025), heart rate (OR, 1.07; P=0.004), IMT (OR, 8.65; P=0.005), and CMT (OR, 1.03; P=0.007) were independent contributing factors to mild NPDR. Spearman's rank correlation test also showed that IMT was negatively correlated with MBR-A (P=0.011). Conclusions: Increased IMT showed a close association with ocular ischemia in patients with type-2 diabetes and contributed to the presence of mild NPDR. These findings suggest that IMT may be an early biomarker of mild NPDR.
The relationship between glutathione levels in leukocytes and ocular clinical parameters in glaucoma. International-journal Peer-reviewed

Takeshi Yabana, Kota Sato, Yukihiro Shiga, Noriko Himori, Kazuko Omodaka, Toru Nakazawa

PloS one　14　(12)　e0227078　2019

DOI： 10.1371/journal.pone.0227078 　

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PURPOSE: To investigate the effect of mitochondrial dysfunction on the autoregulation of blood flow, by measuring levels of glutathione, an indicator of mitochondrial dysfunction, in glaucoma patients. METHODS: Fifty-six OAG patients and 21 age-matched controls underwent a blood assay. Mitochondrial function was measured according to the levels of total glutathione (t-GSH), reduced GSH (GSH), and oxidized GSH (GSSG, glutathione disulfide) in peripheral blood mononuclear cells. Ocular blood flow in the optic nerve head was assessed with laser speckle flowgraphy parameters, including acceleration time index (ATI). We determined correlations between these measurements and other clinical parameters. Furthermore, we investigated the association between glutathione levels and glaucoma with a logistic regression analysis. Finally, we calculated the area under the receiver operating characteristic (ROC) curve in order to determine the power of redox index (the log GSH/GSSG ratio) to distinguish the groups. RESULTS: OAG patients demonstrated significantly higher GSSG levels and a lower redox index than the controls (p = 0.01, p = 0.01, respectively), but total GSH and reduced GSH levels were similar in the OAG subjects and controls (p = 0.80, p = 0.94, respectively). Additionally, redox index was significantly correlated with mean deviation (MD) of the visual field (r = 0.29, p = 0.03) and ATI (r = -0.30, p = 0.03). Multiple linear regression analysis showed that redox index contributed to MD (p = 0.02) and ATI (p = 0.04). The receiver operating characteristic curve (AUC) analysis suggested that redox index could differentiate between control eyes and eyes with glaucoma (AUC; 0.70: 95% interval; 0.57-0.84). The cutoff point for redox index to maximize its sensitivity and specificity was 2.0 (sensitivity: 91.1%, specificity: 42.9%). CONCLUSIONS: These results suggest that redox index is lower in OAG patients than in controls. Thus, it is possible that mitochondrial dysfunction contributes to glaucoma pathogenesis by causing vascular alterations.
Familial Background Factors And Their Association With Non-Organic Visual Loss. International-journal Peer-reviewed

Misuzu Takahashi, Hiroshi Kunikata, Keiichi Kato, Ayako Kawakami, Toru Nakazawa

Clinical ophthalmology (Auckland, N.Z.)　13　2059-2061　2019

DOI： 10.2147/OPTH.S212365 　

ISSN： 1177-5467

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Purpose: To identify new types of clinical findings that could be used to diagnose and treat non-organic visual loss (NOVL). Methods: This study retrospectively examined the records of 191 patients diagnosed with NOVL at the Kato Eye Clinic. Clinical characteristics, including uncorrected visual acuity (UCVA) and complaints of vision loss, were compared in 125 of 191 patients with NOVL and control subjects with organic refractive errors, identified during annual school health checks. If available, familial background data for the NOVL patients were compared with data from a mass population study. Familial background data included the presence of siblings, and whether the mother worked outside the home. Results: Patients with NOVL were more likely to be younger and female (P=0.02, and P<0.001, respectively). UCVA was statistically similar in the better eyes of the NOVL and control subjects (P=0.60), even though the NOVL patients were much more likely to be emmetropic (P<0.001). Complaints of vision loss were significantly more common in the patients with NOVL than in the control subjects (P=0.001). There was no significant difference in the presence of siblings between the subjects in the mass population study and the patients with NOVL (P=0.38), but the NOVL patients were significantly more likely to have a mother who did not work outside the home (P=0.01). Conclusion: Patients with NOVL tended to be younger, female and to complain more often of vision loss, compared to control subjects with organic refractive errors. Familial background factors, including the presence of siblings or a mother working outside the home, seemed not to be associated with the pathogenesis of NOVL, compared to subjects in a mass population study.
Optical coherence tomography angiography assessment of the macular capillary plexus after surgery for macula-off rhegmatogenous retinal detachment. International-journal Peer-reviewed

Naoko Yui, Hiroshi Kunikata, Naoko Aizawa, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　257　(1)　245-248　2019/01

DOI： 10.1007/s00417-018-4133-3 　

ISSN： 0721-832X
Diagnosing superinfection keratitis with multiplex polymerase chain reaction. International-journal Peer-reviewed

Masaaki Yoshida, Takehiro Hariya, Shunji Yokokura, Kazuichi Maruyama, Kota Sato, Sunao Sugita, Yasuhiro Tomaru, Norio Shimizu, Toru Nakazawa

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　24　(12)　1004-1008　2018/12

DOI： 10.1016/j.jiac.2018.06.012 　

ISSN： 1341-321X

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PURPOSE: To report the potential usefulness of multiplex polymerase chain reaction (mPCR) for diagnosing superinfection keratitis caused by herpes simplex virus-1 (HSV-1), bacteria and fungus. METHODS: Case series. Corneal scrapings were analyzed with mPCR for human herpes virus 1-8, bacterial 16S ribosomal DNA (rDNA) and fungal 28S rDNA. RESULTS: Case 1 was a 69-year-old man who presented with refractory infectious keratitis. PCR examination was positive for bacterial 16S rDNA and negative for fungal 28S rDNA. HSV-1 was not examined at this time. A geographic ulcer arose after 2 months of intensive antibacterial treatment. Herpes simplex keratitis (HSK) was suspected; PCR analysis was positive for HSV-1. Corneal scrapings obtained at the initial visit were re-analyzed and found to be HSV-1 positive. Thus, it turned out that this was a case of superinfection keratitis caused by bacteria and HSV-1. Case 2 was a 60-year-old man with corneal ulcer who had received unsuccessful treatment with antibiotics. mPCR analysis was positive for HSV-1, bacterial 16S rDNA and fungal 28S rDNA. The patient was diagnosed with superinfection keratitis caused by HSV-1, bacteria and fungus. Case 3 was an 82-year-old woman who had been treated for HSK and then developed bacterial keratitis during treatment. mPCR analysis was positive for HSV-1 and bacterial 16S rDNA. The patient was diagnosed with superinfection keratitis caused by HSV-1 and bacteria. CONCLUSION: Superinfection keratitis is hard to diagnose because of its atypical manifestation. mPCR has the potential to allow prompt diagnosis and appropriate treatment in these cases.
Prediction of Surgical Outcome After Trabeculectomy for Neovascular Glaucoma With Anterior-segment Optical Coherence Tomography. International-journal Peer-reviewed

Taiki Kokubun, Satoru Tsuda, Hiroshi Kunikata, Noriko Himori, Yu Yokoyama, Kazuko Omodaka, Shiho Kunimatsu-Sanuki, Toru Nakazawa

Journal of glaucoma　27　(12)　1157-1164　2018/12

DOI： 10.1097/IJG.0000000000001081 　

ISSN： 1057-0829

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PURPOSE: To determine the potential of anterior-segment optical coherence tomography (AS-OCT) to predict posttrabeculectomy outcomes in neovascular glaucoma (NVG). PATIENTS AND METHODS: We recruited 45 eyes of 40 NVG patients who underwent trabeculectomy. The patients were divided into success and failure groups based on the posttrabeculectomy outcome after 12 months. AS-OCT findings were compared in the success and failure groups at 1 and 2 weeks and 1, 3, 6, and 12 months. We also analyzed early posttrabeculectomy bleb parameters with multiple logistic regression, stepwise multiple regression, and the receiver operating characteristic curve to evaluate the power of these parameters to predict long-term outcomes. RESULTS: Intraocular pressure at 6 and 12 months was lower in the success group than the failure group (P<0.0016=0.0048). Reflectivity of the bleb wall was higher in the failure group than the success group throughout the study (all: P<0.0016). Age and reflectivity of the bleb wall at 1 week were risk factors for failure with odds ratios for failure of 0.91 and 1.67. The area under the receiver operating characteristic curve for reflectivity of the bleb wall at 1 week was 0.943 with the cutoff set at 128.9 (sensitivity: 85.7%; specificity: 100.0%). Stepwise multiple regression analysis showed that reflectivity of the bleb wall at 1 week independently indicated the bleb survival period (β=-0.84; P<0.001). CONCLUSIONS: AS-OCT-measured reflectivity of the bleb wall, measured at 1 week of trabeculectomy for NVG, might be able to predict of the final status of the bleb.
Reliable detection of low visual acuity in mice with pattern visually evoked potentials. Peer-reviewed

Tokashiki N, Nishiguchi KM, Fujita K, Sato K, Nakagawa Y, Nakazawa T

Scientific reports　8　(1)　15948　2018/10

DOI： 10.1038/s41598-018-34413-8 　
Simple retinal imaging system using a MEMS scanning mirror Peer-reviewed

Neelam Kaushik, Takashi Sasaki, Toru Nakazawa, Kazuhiro Hane

Optical Engineering　57　(9)　095101-1-095101-8　2018/09

DOI： 10.1117/1.OE.57.9.095101 　

ISSN： 0091-3286

eISSN： 1560-2303
Association between mitochondrial DNA damage and ocular blood flow in patients with glaucoma. Peer-reviewed

Inoue-Yanagimachi M, Himori N, Sato K, Kokubun T, Asano T, Shiga Y, Tsuda S, Kunikata H, Nakazawa T

The British journal of ophthalmology　103　(8)　1060-1065　2018/09

DOI： 10.1136/bjophthalmol-2018-312356 　

ISSN： 0007-1161

eISSN： 1468-2079
Metabolomic changes in the mouse retina after optic nerve injury. International-journal Peer-reviewed

Kota Sato, Daisuke Saigusa, Ritsumi Saito, Amane Fujioka, Yurika Nakagawa, Koji M Nishiguchi, Taiki Kokubun, Ikuko N Motoike, Kazuichi Maruyama, Kazuko Omodaka, Yukihiro Shiga, Akira Uruno, Seizo Koshiba, Masayuki Yamamoto, Toru Nakazawa

Scientific reports　8　(1)　11930-11930　2018/08/09

DOI： 10.1038/s41598-018-30464-z 　

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In glaucoma, although axonal injury drives retinal ganglion cell (RGC) death, little is known about the underlying pathomechanisms. To provide new mechanistic insights and identify new biomarkers, we combined latest non-targeting metabolomics analyses to profile altered metabolites in the mouse whole retina 2, 4, and 7 days after optic nerve crush (NC). Ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry and liquid chromatography Fourier transform mass spectrometry covering wide spectrum of metabolites in combination highlighted 30 metabolites that changed its concentration after NC. The analysis displayed similar changes for purine nucleotide and glutathione as reported previously in another animal model of axonal injury and detected multiple metabolites that increased after the injury. After studying the specificity of the identified metabolites to RGCs in histological sections using imaging mass spectrometry, two metabolites, i.e., L-acetylcarnitine and phosphatidylcholine were increased not only preceding the peak of RGC death in the whole retina but also at the RGC layer (2.3-fold and 1.2-fold, respectively). These phospholipids propose novel mechanisms of RGC death and may serve as early biomarkers of axonal injury. The combinatory metabolomics analyses promise to illuminate pathomechanisms, reveal biomarkers, and allow the discovery of new therapeutic targets of glaucoma.
Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina. International-journal Peer-reviewed

Sato K, Shiga Y, Nakagawa Y, Fujita K, Nishiguchi KM, Tawarayama H, Murayama N, Maekawa S, Yabana T, Omodaka K, Katayama S, Feng Q, Tsuda S, Nakazawa T

Investigative ophthalmology & visual science　59　(10)　3943-3951　2018/08

DOI： 10.1167/iovs.18-23784 　

ISSN： 0146-0404

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Purpose: To assess the therapeutic potential of endothelin-converting enzyme-like 1 (Ecel1) in a mouse model of optic nerve crush. Methods: Ecel1 expression was evaluated with real time quantitative (qRT)-PCR, Western blotting, and immunohistochemistry in mouse retinas after optic nerve crush. Vinblastine administration to the optic nerve and the intravitreal injection of N-methyl-d-aspartate (NMDA) were used to assess Ecel1 gene expression. Ecel1 was deleted with an adeno-associated viral (AAV) clustered regulatory interspaced short palindromic repeat (CRISPR)/Cas9 system, and retinal ganglion cell (RGC) survival was investigated with retrograde labeling, qRT-PCR, and visual evoked potential. Results: Optic nerve crush induced Ecel1 expression specifically in the RGCs, peaking on day 4 after optic nerve crush. Ecel1 gene expression was induced by the vinblastine-induced inhibition of axonal flow, but not by NMDA-induced excitotoxicity, even though both are triggers of RGC death. Knockdown of Ecel1 promoted the loss of RGCs after optic nerve crush. Conclusions: Our data suggest that Ecel1 induction is part of the retinal neuroprotective response to axonal injury in mice. These findings might provide insight into novel therapeutic targets for the attenuation of RGC damage, such as occurs in traumatic optic neuropathy.
Chloride imbalance is involved in the pathogenesis of optic neuritis in neuromyelitis optica Peer-reviewed

Tetsuya Akaishi, Toshiyuki Takahashi, Noriko Himori, Takayuki Takeshita, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

Journal of Neuroimmunology　320　98-100　2018/07/15
Publisher: Elsevier B.V.
DOI： 10.1016/j.jneuroim.2018.03.010 　

ISSN： 1872-8421 0165-5728
The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow. International-journal Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Kohei Ichinohasama, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Naoto Honda, Hiroshi Kunikata, Toru Nakazawa

Investigative ophthalmology & visual science　59　(8)　3488-3496　2018/07/02

DOI： 10.1167/iovs.18-23872 　

ISSN： 0146-0404

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Purpose: To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods: This prospective study included 20 eyes of 20 healthy volunteers. The testing protocol had a baseline phase, two elevated IOP phases (+10 and +20 mm Hg), and a recovery phase. IOP was elevated by pushing against the eyelid with a novel tubular device attached to the LSFG apparatus. Measurement parameters in each phase included: LSFG-derived mean blur rate (MBR) and flow acceleration index (FAI); systemic parameters, and IOP. The % change against baseline was calculated for each phase. The protocol was repeated five times to calculate the coefficient of variation (CV) for % change MBR and to determine the effect of mydriasis on % change MBR. We compared % change MBR and FAI and evaluated the relationship between % change ocular perfusion pressure (OPP) and MBR in the choroid and ONH tissue. Results: The % change MBR was highly reproducible (CV: 6.1-8.7%) and not affected by mydriasis (P = 0.57-0.96). The % change MBR and FAI were higher in the ONH tissue than choroid during IOP elevation (P = 0.04). The % change OPP and MBR showed positive linear correlations and two-segmental linear correlations in the choroid and ONH tissue, respectively (P < 0.01). Conclusion: Hemodynamics during IOP elevation differ in the choroid and ONH tissue. LSFG enables highly reproducible assessment of the dynamic autoregulation of ocular BF in the ONH tissue.
Prevalence of anti-retinal antibodies in epiretinal membranes and macular holes. International-journal Peer-reviewed

Hiroshi Kunikata, Kosuke Fujita, Koji M Nishiguchi, Toru Nakazawa

Clinical & experimental ophthalmology　46　(5)　556-558　2018/07

DOI： 10.1111/ceo.13099 　

ISSN： 1442-6404
Validation of formula-predicted glaucomatous optic disc appearances: the Glaucoma Stereo Analysis Study. International-journal Peer-reviewed

Tanito M, Nitta K, Katai M, Kitaoka Y, Yokoyama Y, Omodaka K, Naito T, Yamashita T, Mizoue S, Iwase A, Nakazawa T

Acta ophthalmologica　97　(1)　e42-e49　2018/07

DOI： 10.1111/aos.13816 　

ISSN： 1755-375X

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AIMS: The Glaucoma Stereo Analysis Study (GSAS) is a multicentre collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. Using the GSAS dataset, we previously established a formula for predicting different appearances of glaucomatous optic discs, although the formula lacked validation in an independent dataset. In this study, the formula was validated in another testing dataset. SUBJECTS AND METHODS: Testing dataset contained three-dimensionally analysed optic disc topographic parameters from 93 eyes with primary open-angle glaucoma; six topographic parameters (temporal and nasal rim-disc ratios, mean cup depth, height variation contour, disc tilt angle and rim decentring absolute value) were used for predicting different appearances of glaucomatous optic discs. The agreement between grader-classified optic disc types, that is, focal ischemic (FI), generalized enlargement, myopic glaucomatous (MY), and senile sclerotic (SS) and formula-predicted optic disc types, that is, pFI, pGE, pMY and pSS, were assessed. RESULTS: Based on this formula, the eyes were classified with pFI (21 eyes, 22.6%), pGE (27 eyes, 29.0%), pMY (26 eyes, 28.0%) and pSS (19 eyes, 20.4%) when the top predictive element based on the formula was considered as the optic disc appearance in each eye. The six topographic parameters used in the formula differed significantly among the four predicted optic disc types. Substantial agreement (κ = 0.7496) was seen for the top two predictive elements based on the formula that agreed with the graders' classification in 76 (81.7%) eyes. Among the four optic disc types, the levels of agreement were relatively lower in the SS type (κ = 0.3863-0.5729) compared with the other three optic disc types (κ = 0.7898-0.8956) even though the unclassifiable and mixed optic disc types were excluded from the testing dataset. CONCLUSION: The GSAS classification formula can predict and quantify each component of different optic disc appearances in each eye and provide a novel parameter to describe glaucomatous optic disc characteristics.
Alternative methods to detect anti-TRPM1 antibodies. International-journal Peer-reviewed

Nishiguchi KM, Fujita K, Inoue T, Nakazawa T

Clinical & experimental ophthalmology　47　(1)　148-149　2018/07

DOI： 10.1111/ceo.13365 　

ISSN： 1442-6404
Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy. Peer-reviewed

Nishiguchi KM, Fujita K, Tokashiki N, Komamura H, Takemoto-Kimura S, Okuno H, Bito H, Nakazawa T

Molecular therapy : the journal of the American Society of Gene Therapy　26　(10)　2397-2406　2018/07

DOI： 10.1016/j.ymthe.2018.07.012 　

ISSN： 1525-0016
Predicting the Integrated Visual Field with Wide-Scan Optical Coherence Tomography in Glaucoma Patients Peer-reviewed

Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa

Current Eye Research　43　(6)　754-761　2018/06/03
Publisher: Taylor and Francis Ltd
DOI： 10.1080/02713683.2018.1439065 　

ISSN： 1460-2202 0271-3683
The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome. International-journal Peer-reviewed

Erika Yamada, Noriko Himori, Hiroshi Kunikata, Kazuko Omodaka, Hiromasa Ogawa, Masakazu Ichinose, Toru Nakazawa

Acta ophthalmologica　96　(4)　e479-e484-e484　2018/06

DOI： 10.1111/aos.13693 　

ISSN： 1755-375X

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PURPOSE: Sleep apnoea syndrome (SAS) is often associated with glaucoma, and intermittent hypoxia, present in SAS, can contribute to glaucoma pathogenesis. However, the relationships between SAS, high systemic oxidative stress and the speed of glaucoma progression are unclear. Thus, we investigated these relationships in glaucoma patients with and without SAS. METHODS: Peripheral blood samples were collected from 166 eyes of 166 Japanese patients: 42 controls, 109 open-angle glaucoma (OAG) patients without SAS and 15 OAG patients with SAS. Prognostic factors for visual field defect progression were determined with logistic regression. Diacron reactive oxygen metabolites (dROM) and biological antioxidant potential (BAP) were measured with a free radical analyser. Clinical parameters were also recorded. Intergroup comparisons used the Mann-Whitney U test. RESULTS: Multiple regression analysis showed that SAS was a statistically significant contributing factor to fast visual field defect progression, defined as mean deviation (MD) slope ≤-2.0 dB/Y (SAS: odds ratio (OR) = 14.48; p = 0.002). The non-SAS and SAS groups had similar age, sex, intraocular pressure (IOP), axial length and antiglaucoma drug use. The SAS group had a significantly higher dROM level (p = 0.001), BAP level (p = 0.038) and steeper MD slope (p = 0.001) than the non-SAS group. CONCLUSION: Glaucoma patients with SAS have higher dROM, as well as steeper MD slope, than patients without SAS, suggesting that SAS may induce systemic oxidative stress and promote glaucomatous visual field defect progression.
Anterior-Segment Optical Coherence Tomography for Predicting Postoperative Outcomes After Trabeculectomy. International-journal Peer-reviewed

Taiki Kokubun, Satoru Tsuda, Hiroshi Kunikata, Noriko Himori, Yu Yokoyama, Shiho Kunimatsu-Sanuki, Toru Nakazawa

Current eye research　43　(6)　762-770　2018/06

DOI： 10.1080/02713683.2018.1446535 　

ISSN： 0271-3683

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PURPOSE: To determine whether anterior-segment optical coherence tomography (AS-OCT) can be used to predict post-trabeculectomy bleb outcomes. MATERIALS AND METHODS: We divided 58 eyes of 47 trabeculectomy patients into success or failure groups based on their status at 12 months after surgery. We then compared various AS-OCT measurement parameters between the two groups at 1 and 2 weeks and 1, 3, 6, and 12 months. We also analyzed the early post-trabeculectomy bleb parameters with multiple logistic regression, stepwise multiple regression, and the receiver operating characteristic (ROC) curve, to evaluate the power of these parameters to predict long-term outcomes. RESULTS: Intraocular pressure 3 or more months after trabeculectomy was significantly lower in the success group than the failure group (all: P < 0.0016). Cleft volume was significantly higher 6 or more months after trabeculectomy in the success group than the failure group (P = 0.0027 and <0.0016). Reflectivity of the bleb wall was significantly higher in the failure group than the success group at 2 weeks and all later time points (all: P < 0.0016). Reflectivity of the bleb wall at 2 weeks after trabeculectomy was a risk factor for failure, with an odds ratio (OR) for failure of 2.48 (95% confidence interval, 1.31-4.68, increasing per 10 AU). The area under the ROC curve for reflectivity of the bleb wall at 2 weeks after trabeculectomy was 0.775 when the cutoff value was set at 122.8, with sensitivity, specificity, and OR of 78.3%, 80.0%, and 14.4, respectively. A stepwise multiple regression analysis showed that reflectivity of the bleb wall at 2 weeks was an independent factor indicating postoperative bleb survival period (β = -0.39, P = 0.007). CONCLUSIONS: Reflectivity of the bleb wall, measured by AS-OCT, may be an early post-trabeculectomy predictor of bleb outcome.
Levels of Anti-Retinal Antibodies in Retinal Detachment and Proliferative Vitreoretinopathy. International-journal Peer-reviewed

Reo Ichinohasama, Koji M Nishiguchi, Kosuke Fujita, Naoko Aizawa, Takashi Inoue, Erika Sasaki, Hiroshi Kunikata, Toru Nakazawa

Current eye research　43　(6)　804-809　2018/06

DOI： 10.1080/02713683.2018.1451544 　

ISSN： 0271-3683

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PURPOSE: The purpose of the study is to investigate the correlation between intraocular anti-retinal antibodies and clinical measurements in patients with rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR). MATERIAL AND METHODS: Aqueous humor and vitreous samples were collected from patients with RRD, PVR, and from control subjects with macular hole. The levels of total protein (TP), IgG, and anti-retinal antibodies were determined with a bicinchoninic acid assay, enzyme-linked immunosorbent assay, and dot blot, respectively. Correlations between these measurements were assessed using Pearson's correlation test. Analysis of variance followed by a post-hoc test or the Student t-test was used to compare differences between groups. RESULTS: The levels of anti-retinal antibodies and IgG were correlated with each other (P < 0.010). The IgG concentration was higher in patients with PVR than in controls in both the aqueous humor (P < 0.001) and the vitreous (P < 0.001), but not in patients with RRD. Conversely, TP levels and anti-retinal antibodies in both ocular fluids from RRD and PVR patients did not significantly differ from the controls. In a subgroup analysis, vitreal anti-retinal antibody levels were correlated with average macular thickness in the re-attached macula following surgery for macula-off RRD/PVR (P = 0.012). Furthermore, patients with post-operative cystoid macular edema had a higher level of vitreal anti-retinal antibodies than those without (P = 0.009). CONCLUSIONS: Intravitreal anti-retinal antibodies were increased in the eyes with maculopathy after surgical intervention for RRD/PVR.
Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma. International-journal Peer-reviewed

Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Acta ophthalmologica　96　(4)　e485-e492-e492　2018/06

DOI： 10.1111/aos.13639 　

ISSN： 1755-375X

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PURPOSE: To compare glaucoma severity with ocular microcirculation, measured with either laser speckle flowgraphy (LSFG) or optical coherence tomography angiography (OCTA). METHODS: We retrospectively studied 82 eyes of 82 open-angle glaucoma (OAG) patients who underwent same-day LSFG and OCTA examinations, with 20 eyes of 20 healthy subjects as controls. In OCTA images, vessel density (VD) (%) was calculated in concentric regions (regions 1, 2 and 3: R1, R2 and R3, respectively) defined by 1.6-, 3.2- and 3.6-mm-diameter circles around the optic nerve head (ONH). In R3, the large vessels were automatically masked to calculate pure capillary density (auto R3 VD). LSFG-measured mean blur rate (MBR) was examined in the overall ONH (MA), vessel-area ONH (MV) and tissue-area ONH (MT). RESULTS: Auto R3 VD had high reproducibility (coefficient of variation: 1.65-3.88%) and accurately reflected manual R3 VD [mean bias: -0.0087% (auto R3 VD - manual R3 VD)]. MA and MT decreased significantly with OAG severity, especially in the early OAG stages (control vs. mild: p = 0.003 and p < 0.001, respectively). R1 VD did not change with severity. R2 and auto R3 VD decreased significantly with OAG severity, especially in the severe stages (R2, mild vs. severe: p = 0.008; auto R3 VD, mild vs. severe: p < 0.001, moderate vs. severe: p = 0.028). CONCLUSION: Optical coherence tomography angiography-derived auto R3 VD is novel, reproducible and accurately reflects manual measurements. It is useful for differentiating moderate and advanced glaucoma, while LSFG-derived MT is useful for identifying early glaucoma.
Anti-TRPM1 antibodies in patients with retinal degeneration. International-journal Peer-reviewed

Nishiguchi KM, Fujita K, Inoue T, Nakazawa T

Clinical & experimental ophthalmology　46　(9)　1087-1089　2018/06

DOI： 10.1111/ceo.13341 　

ISSN： 1442-6404
Protruded retinal layers within the optic nerve head neuroretinal rim. International-journal Peer-reviewed

Torres LA, Vianna JR, Jarrar F, Sharpe GP, Araie M, Caprioli J, Demirel S, Girkin CA, Hangai M, Iwase A, Liebmann JM, Mardin CY, Nakazawa T, Quigley HA, Scheuerle AF, Sugiyama K, Tanihara H, Tomita G, Yanagi Y, Burgoyne CF, Chauhan BC

Acta ophthalmologica　96　(4)　e493-e502　2018/06

DOI： 10.1111/aos.13657 　

ISSN： 1755-375X

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PURPOSE: To determine the frequency with which retinal tissues other than the nerve fibre layer, hereafter referred to as protruded retinal layers (PRL), are a component of optical coherence tomography (OCT) neuroretinal rim measurements. METHODS: Ninety healthy (30 White, Black and Japanese, respectively) subjects were included in the study. A radial scan pattern (24 B-scans centred on Bruch's membrane opening [BMO]) was used. For each of the 48 minimum rim width (MRW) measurement points, we determined whether PRL were present, absent or indeterminate. When present, the proportion of PRL within the MRW was quantified. RESULTS: Protruded retinal layers were present in 503 (11.6%), absent in 3805 (88.1%) and indeterminate in 12 (0.3%) measurement points. Overall, 69 (76.6%) subjects had ≥1 points with PRL, with White subjects having the highest frequency and Japanese the lowest (29 [97%] and 18 [60%], respectively; p < 0.01). PRL were present in one-third of points in the temporal sector, but ≤5% in other sectors. When present, the median PRL thickness was 53.0 (interquartile range [IQR]: 33.0 to 78.5) μm, representing 20.6 (IQR: 13.0 to 28.5)% of MRW. Globally, the median PRL thickness comprised 1.3 (IQR: 0.2 to 3.5)% of the MRW; however, in the temporal sector, it exceeded 30% of MRW in some subjects. CONCLUSIONS: Protruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed. There were racial variations in the presence of PRL and a significantly higher frequency of PRL in the temporal sector.
Clinical Science : Efficacy of Vitreous Surgery for Prolonged Cases of Intraocular Inflammatory Disease Peer-reviewed

122　(5)　393-399　2018/05
Publisher:
ISSN： 0029-0203
Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal-tension glaucoma with myopic disc. International-journal Peer-reviewed

Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Acta ophthalmologica　96　(3)　e290-e297-e297　2018/05

DOI： 10.1111/aos.13621 　

ISSN： 1755-375X

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PURPOSE: To investigate factors associated with choroidal microcirculation in the peripapillary chorioretinal atrophy (PPA) zone in eyes with normal-tension glaucoma (NTG) and myopic disc. METHODS: In 100 eyes of 100 NTG patients with myopic disc and 20 eyes of 20 age-matched myopic controls, 4.5 × 4.5 mm scans were made of the optic nerve head with optical coherence tomography angiography (OCTA). Peripapillary chorioretinal atrophy (PPA) area and PPA superficial choroidal image intensity (PPA-CI) were calculated with image j software. Clinical characteristics, laser speckle flowgraphy-measured mean blur rate in the temporal tissue area (temporal MT), the central thresholds (the averaged standard automated perimetry-measured visual field thresholds in the four paracentral points) and 3D-OCT-measured ganglion cell complex thickness in the papillomacular bundle (PMB-GCCT) were recorded. RESULTS: The NTG patients had significantly lower intraocular pressure, PMB-GCCT and central threshold values, and a larger PPA area, than the controls. The area under the receiver operating characteristics curve to differentiate NTG with parafoveal scotoma (PFS) from controls was 0.76 for temporal MT, 0.85 for PPA-CI and 0.87 for PMB-GCCT. Univariate and multivariate analyses revealed that PPA-CI was negatively correlated with age, pulse rate, best-corrected visual acuity, axial length and PPA area, and positively correlated with temporal MT, PMB-GCCT and the central thresholds. CONCLUSION: Peripapillary chorioretinal atrophy (PPA)-CI was associated with temporal MT, ageing, bradycardia, axial length elongation and changes in central retinal structure and visual function in patients with NTG and myopic disc. Thus, microcirculation deep within the PPA zone might be a clinically useful biomarker of PFS in NTG.
Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma Peer-reviewed

Yukihiro Shiga, Japan Glaucoma Society Omics Group (JGS-OG), Masato Akiyama, Koji M. Nishiguchi, Kota Sato, Nobuhiro Shimozawa, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane, Isao Oze, Haruo Mikami, Mariko Naito, Kenji Wakai, Munemitsu Yoshikawa, Masahiro Miyake, Kenji Yamashiro, Kenji Kashiwagi, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Makoto Aihara, Makoto Araie, Tetsuya Yamamoto, Yoshiaki Kiuchi, Makoto Nakamura, Yasuhiro Ikeda, Koh-Hei Sonoda, Tatsuro Ishibashi, Koji Nitta, Aiko Iwase, Shiroaki Shirato, Yoshitaka Oka, Mamoru Satoh, Makoto Sasaki, Nobuo Fuse, Yoichi Suzuki, Ching-Yu Cheng, Chiea Chuen Khor, Mani Baskaran, Shamira Perera, Tin Aung, Eranga N. Vithana, Jessica N. Cooke Bailey, Jae H. Kang, Louis R. Pasquale, Jonathan L. Haines, Janey L. Wiggs, Kathryn P. Burdon, Puya Gharahkhani, Alex W. Hewitt, David A. Mackey, Stuart MacGregor, Jamie E. Craig, R. Rand Allingham, Micheal Hauser, Adeyinka Ashaye, Donald L. Budenz, Stephan Akafo, Susan E.I. Williams, Yoichiro Kamatani, Toru Nakazawa, Michiaki Kubo

Human Molecular Genetics　27　(8)　1486-1496　2018/04/15
Publisher: Oxford University Press
DOI： 10.1093/hmg/ddy053 　

ISSN： 1460-2083 0964-6906
Predictors of Recurrence in Vogt-Koyanagi-Harada Disease. International-journal Peer-reviewed

Kazuichi Maruyama, Aya Noguchi, Ai Shimizu, Yukihiro Shiga, Hiroshi Kunikata, Toru Nakazawa

Ophthalmology. Retina　2　(4)　343-350　2018/04

DOI： 10.1016/j.oret.2017.07.016 　

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PURPOSE: Normally, Vogt-Koyanagi-Harada (VKH) disease has a good prognosis with adequate treatment. However, VKH disease recurs more frequently if diagnosis is delayed or treatment is inadequate. As soon as VKH disease recurs, inflammation is harder to control and the prognosis worsens. Our objective was to study predictors of recurrence in patients with VKH disease. DESIGN: Retrospective case series. PARTICIPANTS: Forty-one eyes of 41 patients (25 women, 16 men) were included in this study. Patients with recurrent attacks of inflammation were classified as recurrent, whereas patients needing only steroid treatment, without any recurrent attacks, were classified as nonrecurrent. METHODS: Descriptive and bivariate analyses were used to characterize disease and outcomes. A blood-flow analysis was performed with laser speckle flowgraphy on days 0, 14, 30, and 60. Choroidal thickness was measured with swept-source OCT, using a 12-radial scan protocol, on the same day as mean blur rate (MBR) measurement. Flare in the anterior chamber also was measured on the same day, using a flare cell meter. MAIN OUTCOME MEASURES: Prevalence of each type of disease pattern and flare, MBR, and thickness of the choroidal layers. RESULTS: The recurrent group initially had lower visual acuity (VA) and higher flare than the nonrecurrent group, but these parameters improved over time and were similar in the groups on days 14, 30, and 60. However, on these days, MBR was significantly lower in the recurrent group than in the nonrecurrent group. Choroidal thickness was not significantly different in the 2 groups at any time point. CONCLUSIONS: We found that patients with recurrent VKH disease had lower VA, higher initial flare number, and a lower response of MBR to treatment than patients with nonrecurrent VKH disease. Thus, VA and flare number during the initial phase, as well as the MBR response to treatment, may be useful in determining the prognosis for VKH disease and choosing therapeutic options.
Endophthalmitis associated with Purpureocillium lilacinum during infliximab treatment for surgically induced necrotizing scleritis, successfully treated with 27-gauge vitrectomy. International-journal Peer-reviewed

Masaaki Yoshida, Shunji Yokokura, Hiroshi Kunikata, Naoko Takada, Kazuichi Maruyama, Masahiro Toyokawa, Kazushi Kashio, Mitsuo Kaku, Toru Nakazawa

International ophthalmology　38　(2)　841-847　2018/04

DOI： 10.1007/s10792-017-0532-4 　

ISSN： 0165-5701

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PURPOSE: To report a case of endophthalmitis associated with Purpureocillium lilacinum (P. lilacinum) during infliximab treatment for surgically induced necrotizing scleritis, successfully treated with 27-gauge vitrectomy. METHODS: A single case report. RESULTS: A 71-year-old man who had undergone immunosuppressive therapy, including infliximab, for surgically induced necrotizing scleritis (SINS) in his left eye complained of visual disturbance and eye pain in the eye. He had a past history of surgery for recurrent pterygium: pterygium excision, amnion transplantation with mitomycin C and limbal transplantation. Visual acuity in the left eye was counting fingers at 30 cm, and intraocular pressure was 3.0 mmHg. Slit-lamp examination revealed the presence of anterior chamber cells (3+), and a B-mode ultrasound scan showed a vitreous opacity. We made a diagnosis of endophthalmitis and performed 27-gauge microincision vitrectomy surgery (27GMIVS) with antibiotic perfusion of ceftazidime, vancomycin and voriconazole. Intraoperative findings included a fungus-like ball-shaped opacity in the vitreous, and a close-to-normal retinal appearance. A vitreous body culture identified the presence of P. lilacinum. After 2 months of antibacterial and antifungal therapy, inflammation decreased and visual acuity recovered to 20/100. CONCLUSIONS: This is the first report of a case of endophthalmitis associated with P. lilacinum during infliximab treatment for SINS. Scleral thinning due to necrotizing scleritis, especially during immunosuppressive therapy, is a risk factor for endophthalmitis. We found that 27GMIVS was a useful strategy for such a challenging clinical situation.
Endogenous Fusarium Endophthalmitis During Treatment for Acute Myeloid Leukemia, Successfully Treated with 25-Gauge Vitrectomy and Antifungal Medications. International-journal Peer-reviewed

Masaaki Yoshida, Naoki Kiyota, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Toyokawa, Shigehiro Hagiwara, Koichi Makimura, Naomi Sato, Shinji Taniuchi, Toru Nakazawa

Mycopathologia　183　(2)　451-457　2018/04

DOI： 10.1007/s11046-017-0221-x 　

ISSN： 0301-486X

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Endogenous fungal endophthalmitis (EFE) caused by disseminated fusariosis is a rare condition that generally has a poor outcome, even with intensive therapy. Here, we describe a case in which this type of EFE was diagnosed with vitreous sampling and was successfully treated with 25-gauge vitrectomy and antifungals, including liposomal amphotericin B and voriconazole. A 16-year-old male patient undergoing treatment for acute myeloid leukemia complained of eye pain and blurred vision in his right eye. Treatment was initiated for a vitreous opacity, possibly associated with herpetic retinitis, but the patient worsened and he was referred to us. Right-eye visual acuity was limited to light perception. We suspected endogenous endophthalmitis and performed 25-gauge vitrectomy with antibiotic perfusion of ceftazidime, vancomycin, and voriconazole. Vitreous culturing revealed the presence of Fusarium solani species complex, and enhanced computed tomography revealed disseminated fusariosis lesions in the lung, spleen, and the soft tissue of the left upper arm. The patient received antifungal treatment with liposomal amphotericin B and voriconazole, and these conditions were eliminated. Visual acuity recovered to 20/400 after additional vitrectomy for tractional retinal detachment and was maintained at this level during the 6-month follow-up period. The success of our treatment allowed the capture of optical coherence tomography images of the retina during fusarium-associated endogenous endophthalmitis and the follow-up period. Furthermore, this case showed that immediate vitrectomy for suspected EFE and intensive treatment can lead to a good clinical outcome.
Interleukin-6 plays a crucial role in the development of subretinal fibrosis in a mouse model. Peer-reviewed

Sato K, Takeda A, Hasegawa E, Jo YJ, Arima M, Oshima Y, Ryoji Y, Nakazawa T, Yuzawa M, Nakashizuka H, Shimada H, Kimura K, Ishibashi T, Sonoda KH

Immunological medicine　41　(1)　23-29　2018/03

DOI： 10.1080/09114300.2018.1451609 　
Pharmacokinetic and safety evaluation of a transscleral sustained unoprostone release device in monkey eyes Peer-reviewed

Nobuhiro Nagai, Shinji Yamada, Junichi Kawasaki, Eri Koyanagi, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe

Investigative Ophthalmology and Visual Science　59　(2)　644-652　2018/02/01
Publisher: Association for Research in Vision and Ophthalmology Inc.
DOI： 10.1167/iovs.17-22429 　

ISSN： 1552-5783 0146-0404
Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning. International-journal Peer-reviewed

Wataru Kobayashi, Akishi Onishi, Hung-Ya Tu, Yuji Takihara, Michiru Matsumura, Kazuko Tsujimoto, Masaru Inatani, Toru Nakazawa, Masayo Takahashi

Investigative ophthalmology & visual science　59　(2)　776-787　2018/02/01

DOI： 10.1167/iovs.17-22406 　

ISSN： 0146-0404

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Purpose: We aimed to establish purification and culture systems for retinal ganglion cells (RGCs) differentiated from mouse and human pluripotent stem cells (PSC) for in vitro and regenerative medicine studies. Methods: We used a two-step immunopanning method to purify RGCs from mouse and human PSC-derived three-dimensional (3D) retinal organoids. To assess the method, we purified RGCs from 3D retinal organoids derived from embryonic stem cells (ESCs) generated from Thy1-EGFP transgenic (TG) mice. In addition, 3D retinal organoids differentiated from human induced PSCs (iPSCs) were cultured for up to differentiation day (DD) 120, and RGCs were purified by immunopanning. RGC marker expressions were confirmed by immunostaining and reverse transcription-quantitative PCR. The purified RGCs were cultured, and neurite outgrowth was measured and analyzed using an IncuCyte Zoom system. Results: Mouse RGCs purified from Thy1-EGFP TG mouse retinas and the ESC-derived 3D retinas could be maintained for approximately 2 to 3 weeks, expressing the markers BRN3B and SMI-312. Purified RGCs from human iPSC-derived retinal organoids expressed RGC markers and could be maintained for up to 4 weeks. The RGCs collected at DD 90 to 110 extended longer neurites than those collected at younger stages. Conclusions: We successfully purified RGCs from mouse and human PSC-derived 3D retinal organoids cultured for approximately 120 days. RGCs from older retinal organoids would be useful for neurite tracking. This method would be effective not only for studying the pathology of human RGC diseases but also for therapeutic drug studies and RGC transplantation.
Discovery of a Cynomolgus Monkey Family With Retinitis Pigmentosa. International-journal Peer-reviewed

Yasuhiro Ikeda, Koji M Nishiguchi, Fuyuki Miya, Nobuhiro Shimozawa, Jun Funatsu, Shunji Nakatake, Kohta Fujiwara, Takashi Tachibana, Yusuke Murakami, Toshio Hisatomi, Shigeo Yoshida, Yasuhiro Yasutomi, Tatsuhiko Tsunoda, Toru Nakazawa, Tatsuro Ishibashi, Koh-Hei Sonoda

Investigative ophthalmology & visual science　59　(2)　826-830　2018/02/01

DOI： 10.1167/iovs.17-22958 　

ISSN： 0146-0404

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Purpose: To accelerate the development of new therapies, an inherited retinal degeneration model in a nonhuman primate would be useful to confirm the efficacy in preclinical studies. In this study, we describe the discovery of retinitis pigmentosa in a cynomolgus monkey (Macaca fascicularis) pedigree. Methods: First, screening with fundus photography was performed on 1443 monkeys at the Tsukuba Primate Research Center. Ophthalmic examinations, such as indirect ophthalmoscopy, ERGs using RETeval, and optic coherent tomography (OCT) measurement, were then performed to confirm diagnosis. Results: Retinal degeneration with cystoid macular edema was observed in both eyes of one 14-year-old female monkey. In her examinations, the full-field ERGs were nonrecordable and the outer layer of the retina in the parafoveal area was not visible on OCT imaging. Moreover, less frequent pigmentary retinal anomalies also were observed in her 3-year-old nephew. His full-field ERGs were almost nonrecordable and the outer layer was not visible in the peripheral retina. His father was her cousin (the son of her mother's older brother) and his mother was her younger half-sibling sister with a different father. Conclusions: The hereditary nature is highly probable (autosomal recessive inheritance suspected). However, whole-exome analysis performed identified no pathogenic mutations in these monkeys.
Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography. International-journal Peer-reviewed

Omodaka K, Maekawa S, An G, Tsuda S, Shiga Y, Takada N, Kikawa T, Takahashi H, Yokota H, Akiba M, Nakazawa T

PloS one　13　(11)　e0207600　2018

DOI： 10.1371/journal.pone.0207600 　

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PURPOSE: To develop a method to quantify, based on swept-source optical coherence tomography (OCT), the 3D structure of the laminar pores in patients with glaucoma. METHODS: This retrospective study examined 160 laminar pores from 8 eyes of 8 cases: 4 normal subjects and 4 open-angle glaucoma (OAG) patients. We reconstructed 3D volume data for a 3 x 3 mm disc, using a method similar to OCT angiography, and segmented the structure of the lamina cribrosa. Then, we manually segmented each laminar pore in sequential C-scan images (>90 slices at 2.6-micron intervals) with VCAT5 (RIKEN, Japan). We compared the control and OAG subjects with the Mann-Whitney U test. Differences were considered significant at p < 0.05. RESULTS: We found that the laminar pores of the OAG patients had a significantly smaller average cross-sectional area, smaller 3D volume (adjusted to the average thickness of the lamina cribrosa), and higher true sphericity, and lower principal value (P1, 2, 3) of the 3D structure data (all: p < 0.0001). The topographic distribution of damaged laminar pores was consistent with the damaged area of the macular map. CONCLUSION: We successfully developed a method to quantify the 3D structure of the laminar pores; providing a useful tool to assess lamina cribrosa-associated risk factors for glaucoma. These findings promise to benefit future investigations into the pathomechanisms of glaucoma.
Surgical results of internal limiting membrane flap inversion and internal limiting membrane peeling for macular hole. International-journal Peer-reviewed

Hiroya Ota, Hiroshi Kunikata, Naoko Aizawa, Toru Nakazawa

PloS one　13　(9)　e0203789　2018

DOI： 10.1371/journal.pone.0203789 　

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PURPOSE: The internal limiting membrane (ILM) is a normal part of the retina, and the outcomes of ILM removal have not been fully investigated. ILM flap inversion is a recently developed technique that increases the success rate of macular hole (MH) surgery. Thus, we compared the anatomical closure rate and visual outcome in patients undergoing microincision vitrectomy surgery (MIVS) with ILM flap inversion or conventional ILM peeling for the treatment of MH. METHODS: The medical records of 90 eyes with MH were reviewed retrospectively. The patients were classified into two groups based on MIVS procedure (group 1: ILM flap inversion, 46 eyes; group 2: ILM peeling, 44 eyes). RESULTS: Preoperative characteristics were similar in the two groups, and there were no significant differences in 1 month- or 6 month-postoperative VA between the groups (P = 0.25 and P = 0.42, respectively). However, the surgical success rate was significantly higher in group 1 than group 2 (P = 0.04; 46/46: 100% and 41/44: 93%, respectively). Multiple regression analysis revealed that axial length and MH diameter were independent factors predicting 6-month postoperative BCVA in group 2 (P = 0.001 and P = 0.03, respectively), and that MH diameter was an independent factor predicting 6-month postoperative VA in group 1 (P = 0.03). Logistic regression analysis revealed that axial length (OR = 2.11; P = 0.02; area under the curve: 0.94; cut off score: 28.4 mm) was an independent factor indicating surgical failure in group 2. CONCLUSION: Our results suggest that MIVS with ILM flap inversion might be best suited to treat MH, particularly in patients with high myopia.
Characteristic Profiles of Inflammatory Cytokines in the Aqueous Humor of Glaucomatous Eyes. International-journal Peer-reviewed

Taiki Kokubun, Satoru Tsuda, Hiroshi Kunikata, Masayuki Yasuda, Noriko Himori, Shiho Kunimatsu-Sanuki, Kazuichi Maruyama, Toru Nakazawa

Ocular immunology and inflammation　26　(8)　1177-1188　2018

DOI： 10.1080/09273948.2017.1327605 　

ISSN： 0927-3948

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PURPOSE: To analyze cytokine profiles of the aqueous humor of eyes with primary open-angle glaucoma (POAG), neovascular glaucoma (NVG), and cataract (as controls). METHODS: A multiplex bead assay was used to measure concentrations of 27 cytokines in aqueous humor samples from 54 eyes. RESULTS: Detection rates were as follows: IL-7: NVG higher than POAG; IL-10: POAG lower than cataract or NVG; and GM-CSF: cataract higher than POAG or NVG. Concentrations were as follows: IL-8, IP-10, MCP-1, and MIP-1β: POAG and NVG higher than cataract; IL-9: POAG lower than NVG; IL-12: POAG lower than cataract or NVG; and VEGF: NVG higher than cataract or POAG and POAG lower than cataract. Further analysis showed that IL-8, IP-10, MCP-1, and MIP-1β were correlated with intraocular pressure and age. CONCLUSIONS: The detection rates and levels of various cytokines had different patterns in POAG and NVG patients, suggesting distinctive alterations in the microenvironment in different types of glaucoma.
Preperimetric Glaucoma Prospective Study (PPGPS): Predicting Visual Field Progression With Basal Optic Nerve Head Blood Flow in Normotensive PPG Eyes. International-journal Peer-reviewed

Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Hiroshi Kunikata, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto, Toru Nakazawa

Translational vision science & technology　7　(1)　11-11　2018/01

DOI： 10.1167/tvst.7.1.11 　

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Purpose: To investigate the site specificity of visual field changes in eyes with normotensive preperimetric glaucoma (PPG), and to determine factors influencing visual field progression. Methods: This prospective study comprised 84 eyes of 84 normotensive PPG patients followed for at least 16 months. Optic nerve head (ONH) blood flow was assessed with tissue-area mean blur rate (MBRT), derived from laser speckle flowgraphy. Total deviation (TD) was measured in each sector of the Garway-Heath map to evaluate the site specificity of visual field loss. Subjects with a TD slope in the first quartile were classified as progressive, and other subjects as nonprogressive. Linear and multiple regression analyses were performed to determine factors affecting visual field progression. Results: TD in the superior sector significantly decreased in the subjects overall during the follow-up periods (-0.48 ± 1.92 dB/y, P = 0.025). Linear regression analysis showed that basal MBRT-inferior was correlated significantly with TD-superior slope (r = 0.332, P = 0.002). Furthermore, basal MBRT was significantly lower in this sector in the progressive than the nonprogressive group (P = 0.010). Multiple linear regression analysis revealed that basal MBRT-inferior was the only predictive factor for TD-superior slope (β = 0.329, P = 0.005). Conclusions: These findings suggest that superior-sector visual field progression is most common in normotensive PPG eyes, and that reduced basal ONH blood flow is associated with visual field progression. Translational Relevance: These findings provide new insight into the involvement of ONH blood flow impairment in glaucoma pathogenesis, and demonstrate the importance of assessing ONH blood flow to determine visual field progression in normotensive PPG.
The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy. International-journal Peer-reviewed

Azusa Ito, Hiroshi Kunikata, Masayuki Yasuda, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Kazuki Hashimoto, Naoko Aizawa, Hideki Katagiri, Toru Nakazawa

Journal of ophthalmology　2018　2439691-2439691　2018

DOI： 10.1155/2018/2439691 　

ISSN： 2090-004X

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Purpose: Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods: This study included 42 eyes of 42 type 2 diabetes patients (median age: 54 years) with no DR or with mild nonproliferative DR. Standard statistical techniques were used to determine associations between clinical findings. Results: Sural sensory conduction velocity (SCV) and tibial motor conduction velocity (MCV) were significantly lower in mild nonproliferative DR patients than patients with no DR (P = 0.008 and P = 0.01, resp.). Furthermore, logistic regression analyses revealed that sural SCV and tibial MCV were independent factors contributing to the presence of mild nonproliferative DR (OR 0.83, P = 0.012 and OR 0.69 P = 0.02, resp.). Tibial MCV was correlated with choroidal thickness (CT) (P = 0.01), and a multiple regression analysis revealed that age, tibial MCV, and carotid intima-media thickness were independent associating factors with CT (P = 0.035, P = 0.015, and P = 0.008, resp.). Conclusions: Our findings suggest that reduced NCV may be closely associated with early DR in type 2 diabetes patients. Thus, reduced nerve conduction is a potential early biomarker of DR.
A Small Disc Area Is a Risk Factor for Visual Field Loss Progression in Primary Open-Angle Glaucoma: The Glaucoma Stereo Analysis Study. International-journal Peer-reviewed

Kitaoka Y, Tanito M, Yokoyama Y, Nitta K, Katai M, Omodaka K, Nakazawa T

Journal of ophthalmology　2018　8941489-8941489　2018

DOI： 10.1155/2018/8941489 　

ISSN： 2090-004X

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Purpose: The Glaucoma Stereo Analysis Study, a cross-sectional multicenter collaborative study, used a stereo fundus camera (nonmyd WX) to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients. We compared the associations of each parameter between the visual field loss progression group and no-progression group. Methods: The study included 187 eyes of 187 patients with primary open-angle glaucoma or normal-tension glaucoma. We divided the mean deviation (MD) slope values of all patients into the progression group (<-0.3 dB/year) and no-progression group (≧-0.3 dB/year). ONH morphological parameters were calculated with prototype analysis software. The correlations between glaucomatous visual field progression and patient characteristics or each ONH parameter were analyzed with Spearman's rank correlation coefficient. Results: The MD slope averages in the progression group and no-progression group were -0.58 ± 0.28 dB/year and 0.05 ± 0.26 dB/year, respectively. Among disc parameters, vertical disc width (diameter), disc area, cup area, and cup volume in the progression group were significantly less than those in the no-progression group. Logistic regression analysis revealed a significant association between the visual field progression and disc area (odds ratio 0.49/mm2 disc area). Conclusion: A smaller disc area may be associated with more rapid glaucomatous visual field progression.
Quantitative MRI evaluation of glaucomatous changes in the visual pathway. International-journal Peer-reviewed

Fukuda M, Omodaka K, Tatewaki Y, Himori N, Matsudaira I, Nishiguchi KM, Murata T, Taki Y, Nakazawa T

PloS one　13　(7)　e0197027　2018

DOI： 10.1371/journal.pone.0197027 　

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BACKGROUND: The aims of this study were to investigate glaucomatous morphological changes quantitatively in the visual cortex of the brain with voxel-based morphometry (VBM), a normalizing MRI technique, and to clarify the relationship between glaucomatous damage and regional changes in the visual cortex of patients with open-angle glaucoma (OAG). METHODS: Thirty-one patients with OAG (age: 55.9 ± 10.7, male: female = 9: 22) and 20 age-matched controls (age: 54.9 ± 9.8, male: female = 10: 10) were included in this study. The cross-sectional area (CSA) of the optic nerve was manually measured with T2-weighed MRI. Images of the visual cortex were acquired with T1-weighed 3D magnetization-prepared rapid acquisition with gradient echo (MPRAGE) sequencing, and the normalized regional visual cortex volume, i.e., gray matter density (GMD), in Brodmann areas (BA) 17, 18, and 19, was calculated with a normalizing technique based on statistic parametric mapping 8 (SPM8) analysis. We compared the regional GMD of the visual cortex in the control subjects and OAG patients. Spearman's rank correlation analysis was used to determine the relationship between optic nerve CSA and GMD in BA 17, 18, and 19. RESULTS: We found that the normal and OAG patients differed significantly in optic nerve CSA (p < 0.001) and visual cortex GMD in BA 17 (p = 0.030), BA 18 (p = 0.003), and BA 19 (p = 0.005). In addition, we found a significant correlation between optic nerve CSA and visual cortex GMD in BA 19 (r = 0.33, p = 0.023), but not in BA 17 (r = 0.17, p = 0.237) or BA 18 (r = 0.24, p = 0.099). CONCLUSION: Quantitative MRI parametric evaluation of GMD can detect glaucoma-associated anatomical atrophy of the visual cortex in BA 17, 18, and 19. Furthermore, GMD in BA 19 was significantly correlated to the damage level of the optic nerve, as well as the retina, in patients with OAG. This is the first demonstration of an association between the cortex of the brain responsible for higher-order visual function and glaucoma severity. Evaluation of the visual cortex with MRI is thus a very promising potential method for objective examination in OAG.
Comparison of Machine-Learning Classification Models for Glaucoma Management. International-journal Peer-reviewed

An G, Omodaka K, Tsuda S, Shiga Y, Takada N, Kikawa T, Nakazawa T, Yokota H, Akiba M

Journal of healthcare engineering　2018　6874765-6874765　2018

DOI： 10.1155/2018/6874765 　

ISSN： 2040-2295

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This study develops an objective machine-learning classification model for classifying glaucomatous optic discs and reveals the classificatory criteria to assist in clinical glaucoma management. In this study, 163 glaucoma eyes were labelled with four optic disc types by three glaucoma specialists and then randomly separated into training and test data. All the images of these eyes were captured using optical coherence tomography and laser speckle flowgraphy to quantify the ocular structure and blood-flow-related parameters. A total of 91 parameters were extracted from each eye along with the patients' background information. Machine-learning classifiers, including the neural network (NN), naïve Bayes (NB), support vector machine (SVM), and gradient boosted decision trees (GBDT), were trained to build the classification models, and a hybrid feature selection method that combines minimum redundancy maximum relevance and genetic-algorithm-based feature selection was applied to find the most valid and relevant features for NN, NB, and SVM. A comparison of the performance of the three machine-learning classification models showed that the NN had the best classification performance with a validated accuracy of 87.8% using only nine ocular parameters. These selected quantified parameters enabled the trained NN to classify glaucomatous optic discs with relatively high performance without requiring color fundus images.
Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica Peer-reviewed

Tetsuya Akaishi, Kimihiko Kaneko, Noriko Himori, Takayuki Takeshita, Toshiyuki Takahashi, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

Journal of Neuroimmunology　313　10-15　2017/12/15
Publisher: Elsevier B.V.
DOI： 10.1016/j.jneuroim.2017.10.001 　

ISSN： 1872-8421 0165-5728
Optic nerve head microcirculation in autosomal dominant optic atrophy and normal-tension glaucoma Peer-reviewed

Noriko Himori, Hiroshi Kunikata, Maki Inoue, Takayuki Takeshita, Koji M. Nishiguchi, Toru Nakazawa

ACTA OPHTHALMOLOGICA　95　(8)　e799-e800　2017/12

DOI： 10.1111/aos.13353 　

ISSN： 1755-375X

eISSN： 1755-3768
The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation Peer-reviewed

Shigeto Maekawa, Kota Sato, Kosuke Fujita, Reiko Daigaku, Hiroshi Tawarayama, Namie Murayama, Satoru Moritoh, Takeshi Yabana, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Koji M. Nishiguchi, Toru Nakazawa

Scientific Reports　7　(1)　6885　2017/12/01
Publisher: Nature Publishing Group
DOI： 10.1038/s41598-017-06969-4 　

ISSN： 2045-2322
Preperimetric Glaucoma Prospective Observational Study (PPGPS): Design, baseline characteristics, and therapeutic effect of tafluprost in preperimetric glaucoma eye Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto, Toru Nakazawa

PLOS ONE　12　(12)　e0188692　2017/12

DOI： 10.1371/journal.pone.0188692 　

ISSN： 1932-6203
Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7 Peer-reviewed

Yukihiro Shiga, Japan Glaucoma Society Omics Group (JGS-OG), Koji M. Nishiguchi, Yosuke Kawai, Kaname Kojima, Kota Sato, Kosuke Fujita, Mai Takahashi, Kazuko Omodaka, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Nobuo Fuse, Masayuki Yamamoto, Jun Yasuda, Masao Nagasaki, Toru Nakazawa

PLoS ONE　12　(12)　e0186678　2017/12/01
Publisher: Public Library of Science
DOI： 10.1371/journal.pone.0186678 　

ISSN： 1932-6203
Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters Peer-reviewed

Kazuko Omodaka, Guangzhou An, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hidetoshi Takahashi, Hideo Yokota, Masahiro Akiba, Toru Nakazawa

PLOS ONE　12　(12)　e0190012　2017/12

DOI： 10.1371/journal.pone.0190012 　

ISSN： 1932-6203
Phase Difference-Enhanced Magnetic Resonance (MR) Imaging (PADRE) Technique for the Detection of Age-Related Microstructural Changes in Optic Radiation: Comparison with Diffusion Tensor Imaging (DTI). International-journal Peer-reviewed

Yasuko Tatewaki, Tatsushi Mutoh, Benjamin Thyreau, Kazuko Omodaka, Takaki Murata, Atsushi Sekiguchi, Toru Nakazawa, Yasuyuki Taki

Medical science monitor : international medical journal of experimental and clinical research　23　5495-5503　2017/11/19

DOI： 10.12659/msm.905571 　

ISSN： 1234-1010

eISSN： 1643-3750

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BACKGROUND The optic radiation (OR) is a white-matter bundle connecting the lateral geniculate body and the visual cortex. Phase difference-enhanced imaging (PADRE) is a new MRI technique that is able to achieve precise delineation of the OR. The aim of this study was to investigate the effect of age on the volume and signal intensity of the OR using PADRE, and to establish a volumetric reference of the OR from a healthy population, compared with diffusion tensor imaging (DTI). MATERIAL AND METHODS Thirty-nine healthy volunteers underwent MR imaging with PADRE and DTI sequences on a 3.0-T scanner. For the volumetric analysis with PADRE, the OR corresponding to the external sagittal stratum was manually traced, while an automated thresholding method was used for the DTI-based volumetric analysis of the OR. RESULTS The mean right and left OR volumes measured from the PADRE images were 1469.0±242.4 mm³ and 1372.6±310.2 mm³, respectively. Although OR volume showed no significant correlation with age, the normalized OR signal intensity showed a linear correlation with increasing age (r²=0.50-0.53; P<0.01). The OR signal intensity on PADRE and DTI-related quantitative parameters for the OR showed significant correlations (r²=0.46-0.49; P<0.01). CONCLUSIONS The PADRE technique revealed exceptional preservation of OR volume, even in later life. Moreover, PADRE was able to detect age-related changes in signal intensity of the OR and may contribute to future analyses of pathological neurodegeneration in patients with glaucoma and multiple sclerosis.
Comprehensive analysis of vitreous specimens for uveitis classification: a prospective multicentre observational study. International-journal Peer-reviewed

Kazuichi Maruyama, Tohru Inaba, Sunao Sugita, Ryo Ichinohasama, Kenji Nagata, Shigeru Kinoshita, Manabu Mochizuki, Toru Nakazawa

BMJ open　7　(11)　e014549　2017/11/16

DOI： 10.1136/bmjopen-2016-014549 　

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PURPOSE: To determine the clinical relevance of vitreous biomarkers in patients with uveitis. DESIGN: Multicentre, prospective, observational study. SETTING: Uveitis outpatient clinics of two academic medical centres in Japan. PATIENT POPULATION: This study included 234 eyes of 191 patients with various uveitis aetiologies: definitive sarcoidosis (61 eyes of 46 patients), suspected sarcoidosis (60 eyes of 45 patients), intraocular tumour (34 eyes of 27 patients), viral infection (20 eyes of 18 patients), non-sarcoidosis (16 eyes of 16 patients) and unknown aetiology (43 eyes of 39 patients). OBSERVATION PROCEDURE: Vitreous samples (taken by pars planta vitrectomy) were analysed with flow cytometry, cytology and multiplex PCR analysis. MAIN OUTCOME MEASURES: The primary outcome measures were the diagnostic values of various biomarkers (T cells, B cells and pathogen DNA) in vitreous samples. The secondary outcome was visual acuity after vitrectomy. RESULTS: Sarcoidosis showed higher CD4/CD8 or CD4+ measurements than other aetiologies (p<0.01). In samples with viral infection, pathogen DNA was detected, and CD8+ counts were higher than the other aetiologies (p<0.01). Eyes with tumour had higher CD19+ (p<0.05). Non-sarcoidosis had lower CD4/CD8 than sarcoidosis, higher CD8+ than sarcoidosis and lower CD19+ than tumour (p<0.01). Unknown uveitis had lower CD4/CD8 than sarcoidosis (p<0.01), and higher CD4/CD8 than non-sarcoidosis, viral infection or tumour (p<0.001). Visual acuity improved after vitrectomy (p<0.001). CONCLUSIONS: Uveitis aetiologies had distinct vitreous biomarker profiles, especially of infiltrating lymphocytes. Analyses of CD4/CD8 ratio, T-lymphocyte and B-lymphocyte subset, and pathogen DNA in vitreous samples have good safety profiles and high diagnostic value for uveitis classification. TRIAL REGISTRATION NUMBER: UMIN000004980; Pre-results.
Phase Difference-Enhanced Magnetic Resonance (MR) Imaging (PADRE) Technique for the Detection of Age-Related Microstructural Changes in Optic Radiation: Comparison with Diffusion Tensor Imaging (DTI) Peer-reviewed

Yasuko Tatewaki, Tatsushi Mutoh, Benjamin Thyreau, Kazuko Omodaka, Takaki Murata, Atsushi Sekiguchi, Toru Nakazawa, Yasuyuki Taki

MEDICAL SCIENCE MONITOR　23　5495-5503　2017/11

DOI： 10.12659/MSM.905571 　

ISSN： 1643-3750
Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of chaperone molecules under conditions of endoplasmic reticulum stress Peer-reviewed

Orie Nakamura, Satoru Moritoh, Kota Sato, Shigeto Maekawa, Namie Murayama, Noriko Himori, Kazuko Omodaka, Tetsuya Sogon, Toru Nakazawa

Clinical Ophthalmology　11　1825-1834　2017/10/11
Publisher: Dove Medical Press Ltd
DOI： 10.2147/OPTH.S145159 　

ISSN： 1177-5483 1177-5467
Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma Peer-reviewed

Kazuko Omodaka, Tsutomu Kikawa, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Haruka Sato, Junko Ohuchi, Akiko Matsumoto, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa

PLOS ONE　12　(10)　e0185649　2017/10

DOI： 10.1371/journal.pone.0185649 　

ISSN： 1932-6203
Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening Peer-reviewed

Naoki Miura, Kazuko Omodaka, Koudai Kimura, Akiko Matsumoto, Tsutomu Kikawa, Seri Takahashi, Naoko Takada, Hidetoshi Takahashi, Kazuichi Maruyama, Masahiro Akiba, Tetsuya Yuasa, Toru Nakazawa

PLOS ONE　12　(10)　e0185573　2017/10

DOI： 10.1371/journal.pone.0185573 　

ISSN： 1932-6203
Bullous exudative retinal detachment after retinal pattern scan laser photocoagulation in diabetic retinopathy Peer-reviewed

Shohei Nishikawa, Hiroshi Kunikata, Naoko Aizawa, Toru Nakazawa

Case Reports in Ophthalmology　8　(3)　475-481　2017/09/14
Publisher: S. Karger AG
DOI： 10.1159/000480723 　

ISSN： 1663-2699

eISSN： 1663-2699
Evaluating retinal vessel diameter with optical coherence tomography in normal-tension glaucoma patients Peer-reviewed

Takeshi Yabana, Yukihiro Shiga, Ryo Kawasaki, Kazuko Omodaka, Hidetoshi Takahashi, Koudai Kimura, Kyosuke Togashi, Takaaki Horii, Kei Sasaki, Testuya Yuasa, Toru Nakazawa

JAPANESE JOURNAL OF OPHTHALMOLOGY　61　(5)　378-387　2017/09

DOI： 10.1007/s10384-017-0523-z 　

ISSN： 0021-5155

eISSN： 1613-2246
Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation Peer-reviewed

Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　255　(8)　1633-1642　2017/08

DOI： 10.1007/s00417-017-3627-8 　

ISSN： 0721-832X

eISSN： 1435-702X
Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage Peer-reviewed

Yoshimi Asano, Noriko Himori, Hiroshi Kunikata, Mai Yamazaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toru Nakazawa

SCIENTIFIC REPORTS　7　(1)　8032　2017/08

DOI： 10.1038/s41598-017-08624-4 　

ISSN： 2045-2322
Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening-Minimum Rim Width in a Normal Japanese Population Peer-reviewed

Makoto Araie, Aiko Iwase, Kazuhisa Sugiyama, Toru Nakazawa, Goji Tomita, Masanori Hangai, Yasuo Yanagi, Hiroshi Murata, Hidenobu Tanihara, Claude F. Burgoyne, Balwantray C. Chauhan

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　58　(10)　4106-4113　2017/08

DOI： 10.1167/iovs.17-22057 　

ISSN： 0146-0404

eISSN： 1552-5783
Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma Peer-reviewed

Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Hiroyuki Iijima, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuhide Kawase, Yukihiro Shiga, Koji M. Nishiguchi, Toru Nakazawa, Mineo Ozaki, Makoto Araie

PLOS ONE　12　(8)　e0183709　2017/08

DOI： 10.1371/journal.pone.0183709 　

ISSN： 1932-6203
The role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma Peer-reviewed

Shiho Kunimatsu-Sanuki, Aiko Iwase, Makoto Araie, Yuki Aoki, Takeshi Hara, Takeo Fukuchi, Sachiko Udagawa, Shinji Ohkubo, Kazuhisa Sugiyama, Chota Matsumoto, Toru Nakazawa, Takuhiro Yamaguchi, Hiroshi Ono

BRITISH JOURNAL OF OPHTHALMOLOGY　101　(7)　896-901　2017/07

DOI： 10.1136/bjophthalmol-2016-308754 　

ISSN： 0007-1161

eISSN： 1468-2079
Multiplex polymerase chain reaction for pathogen detection in donor/recipient corneal transplant tissue and donor storage solution Peer-reviewed

Takehiro Hariya, Kazuichi Maruyama, Sunao Sugita, Masayo Takahashi, Shunji Yokokura, Kota Sato, Yasuhiro Tomaru, Norio Shimizu, Toru Nakazawa

SCIENTIFIC REPORTS　7　(1)　5973　2017/07

DOI： 10.1038/s41598-017-06344-3 　

ISSN： 2045-2322
静岡県立子ども病院における虐待を疑われた小児の眼底所見

橋本清香, 西村香澄, 澤田麻友, 土屋陽子, 彦谷明子, 堀田喜裕, 中澤徹, 佐藤美保

眼科臨床紀要　10　(6)　507-507　2017/06
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury Peer-reviewed

Kosuke Fujita, Koji M. Nishiguchi, Yukihiro Shiga, Toru Nakazawa

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT　5　130-141　2017/06

DOI： 10.1016/j.omtm.2017.04.003 　

ISSN： 2329-0501
The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Primary Open-Angle Glaucoma Patients Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Shiori Suzuki, Marika Sato, Naoko Takada, Shigeto Maekawa, Kazuko Omodaka, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　58　(7)　3181-3188　2017/06

DOI： 10.1167/iovs.17-21648 　

ISSN： 0146-0404

eISSN： 1552-5783
Traditional medicine as a potential treatment for Flammer syndrome. International-journal Peer-reviewed

Akiko Kikuchi, Yukihiro Shiga, Shin Takayama, Ryutaro Arita, Shigeto Maekawa, Soichiro Kaneko, Noriko Himori, Tadashi Ishii, Toru Nakazawa

The EPMA journal　8　(2)　171-175　2017/06

DOI： 10.1007/s13167-017-0091-9 　

ISSN： 1878-5077
Functional visual acuity measurement in glaucoma Peer-reviewed

Haruka Sato, Hiroshi Kunikata, Junko Ouchi, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　45　(4)　414-415　2017/05

DOI： 10.1111/ceo.12889 　

ISSN： 1442-6404

eISSN： 1442-9071
Characteristics of cases needing advanced treatment for intractable Posner-Schlossman syndrome. International-journal Peer-reviewed

Kazuichi Maruyama, Yuko Maruyama, Sunao Sugita, Kazuhiko Mori, Yu Yokoyama, Shiho Sanuki-Kunimatsu, Hiroko Nakagawa, Shigeru Kinoshita, Manabu Mochizuki, Toru Nakazawa

BMC ophthalmology　17　(1)　45-45　2017/04/11

DOI： 10.1186/s12886-017-0438-y 　

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BACKGROUND: In Posner-Schlossman syndrome (PSS), which is characterized by recurrent unilateral attacks of ocular hypertension. Surgical treatment is sometimes necessary because intraocular pressure (IOP) cannot be controlled with anti-glaucoma medications. To identify the clinical features of Posner-Schlossman syndrome (PSS) indicative of the need for intraocular pressure (IOP)-controlling surgery. METHODS: This study was a retrospective case-series analysis of the clinical charts of 33 patients diagnosed with PSS, who underwent surgery to control IOP or received medication only. Various clinical factors were compared between the surgical and medication groups. RESULTS: The surgical group had a higher corneal endothelial cell (CEC) density loss (p < 0.05), higher maximum IOP (p < 0.01), greater visual field loss (p < 0.01) and higher positive number for cytomegalovirus (CMV) (p < 0.001) than the non-surgical group. Eighteen of the 33 patients had a high CEC reduction ratio. Of these 18, 16 required glaucoma surgery. CONCLUSIONS: PSS patients with a higher CEC reduction ratio, higher maximum IOP, greater visual field loss and higher positive number for CMV in the aqueous humor tended to be more likely to require progressive treatment, such as glaucoma surgery.
Estimated retinal ganglion cell counts for assessing a wide range of glaucoma stages, from preperimetric to advanced Peer-reviewed

Mai Yamazaki, Kazuko Omodaka, Hidetoshi Takahashi, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　45　(3)　310-313　2017/04

DOI： 10.1111/ceo.12852 　

ISSN： 1442-6404

eISSN： 1442-9071
Longitudinal changes of ocular blood flow using laser speckle flowgraphy during normal pregnancy Peer-reviewed

Takahiro Sato, Junichi Sugawara, Naoko Aizawa, Noriyuki Iwama, Fumiaki Takahashi, Michiyo Nakamura-Kurakata, Masatoshi Saito, Takashi Sugiyama, Hiroshi Kunikata, Toru Nakazawa, Nobuo Yaegashi

PLOS ONE　12　(3)　e0173127　2017/03

DOI： 10.1371/journal.pone.0173127 　

ISSN： 1932-6203
Twenty-nine-gauge dual-chandelier retroillumination for the non-open-sky continuous curvilinear capsulorhexis in the penetrating keratoplasty triple procedure Peer-reviewed

Shunji Yokokura, Takehiro Hariya, Wataru Kobayashi, Yasuhiko Meguro, Kohji Nishida, Toru Nakazawa

JOURNAL OF CATARACT AND REFRACTIVE SURGERY　43　(3)　305-308　2017/03

DOI： 10.1016/j.jcrs.2017.02.004 　

ISSN： 0886-3350

eISSN： 1873-4502
黄斑浮腫を伴う網膜静脈分枝閉塞症の保存的治療における視力改善指標 Peer-reviewed

中山紘子, 多田麻子, 針谷威寛, 浅野俊文, 中澤徹, 佐藤肇

日本眼科学会雑誌　121　(2)　130-137　2017/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection Peer-reviewed

Kotaro Yamamoto, Kota Sato, Masayoshi Yukita, Masayuki Yasuda, Kazuko Omodaka, Morin Ryu, Kosuke Fujita, Koji M. Nishiguchi, Shigeki Machida, Toru Nakazawa

JOURNAL OF NEUROCHEMISTRY　140　(3)　495-508　2017/02

DOI： 10.1111/jnc.13902 　

ISSN： 0022-3042

eISSN： 1471-4159
The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma Peer-reviewed

Noriko Himori, Hiroshi Kunikata, Ryo Kawasaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toshio Miyata, Toru Nakazawa

BRITISH JOURNAL OF OPHTHALMOLOGY　101　(2)　233-238　2017/02

DOI： 10.1136/bjophthalmol-2016-309504 　

ISSN： 0007-1161

eISSN： 1468-2079
Indices of Visual Improvement after Conservative Treatment for Branch Retinal Vein Occlusion with Macular Edema. Peer-reviewed

Hiroko Nakayama, Asako Tada, Takehiro Hariya, Toshifumi Asano, Toru Nakazawa, Hajime Sato

Nippon Ganka Gakkai zasshi　121　(2)　130-7　2017/02

ISSN： 0029-0203

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Purpose: To identify indices of visual improvement after conservative treatment for branch retinal vein occlusion (BRVO) with macular edema. Methods: We retrospectively reviewed the charts of 33 eyes of 33 patients with BRVO with macular edema. Inclusion criteria were 1) onset within 4 months, 2) decimal visual acuity of 0.05 to 0.5, and 3) minimum central subfield thickness (CST) of 250 μm. After 3 months of treatment with oral aspirin and kallidinogenase, the patients were divided into two groups: those with logarithmic minimum angle of resolution (logMAR) visual improvement of 0.3 or more (14 eyes) and less than 0.3 (19 eyes). We then compared systemic and ocular findings in the groups. Results: The groups differed significantly in logMAR improvement after 1 month (p<0.01) and in CST change after 1 month (p<0.05). Multiple logistic regression analysis showed that CST change after 1 month was a significant index of visual improvement (p<0.05). The cutoff value for visual improvement was -30 μm (sensitivity: 78.6, specificity: 68.4, positive predictive value: 64.7, negative predictive value: 81.3). Conclusion: A decrease in CST of more than 30 μm 1 month after conservative treatment indicates that visual acuity is likely to be improved after 3 months.
Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors Peer-reviewed

Hiroshi Kunikata, Tomoaki Ida, Kota Sato, Naoko Aizawa, Tomohiro Sawa, Hiroshi Tawarayama, Namie Murayama, Shigemoto Fujii, Takaaki Akaike, Toru Nakazawa

SCIENTIFIC REPORTS　7　41984　2017/02

DOI： 10.1038/srep41984 　

ISSN： 2045-2322
Differentiation of glaucomatous optic discs with different appearances using optic disc topography parameters: The Glaucoma Stereo Analysis Study Peer-reviewed

Masaki Tanito, Koji Nitta, Maki Katai, Yasushi Kitaoka, Yu Yokoyama, Kazuko Omodaka, Toru Nakazawa

PLOS ONE　12　(2)　e0169858　2017/02

DOI： 10.1371/journal.pone.0169858 　

ISSN： 1932-6203
MEMS-based retinal-imaging system for visual health monitoring

Neelam Kaushik, Takashi Sasaki, Yoshiki Takahashi, Toru Nakazawa, Kazuhiro Hane

Proceedings of the International Display Workshops　2　1319-1321　2017
Publisher: International Display Workshops
ISSN： 1883-2490
Brimonidine Enhances the Electrophysiological Response of Retinal Ganglion Cells through the Trk-MAPK/ERK and PI3K Pathways in Axotomized Eyes Peer-reviewed

Masayoshi Yukita, Kazuko Omodaka, Shigeki Machida, Masayuki Yasuda, Kota Sato, Kazuichi Maruyama, Koji M. Nishiguchi, Toru Nakazawa

CURRENT EYE RESEARCH　42　(1)　125-133　2017/01

DOI： 10.3109/02713683.2016.1153112 　

ISSN： 0271-3683

eISSN： 1460-2202
Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic CYP3A4 Inhibition by Clarithromycin Plus Voriconazole Peer-reviewed

Eikan Mishima, Kazuichi Maruyama, Toru Nakazawa, Takaaki Abe, Sadayoshi Ito

INTERNAL MEDICINE　56　(13)　1687-1690　2017

DOI： 10.2169/internalmedicine.56.8313 　

ISSN： 0918-2918

eISSN： 1349-7235
Long-Term Protection of Genetically Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery Peer-reviewed

Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(15)　6527-6538　2016/12

DOI： 10.1167/iovs.16-20453 　

ISSN： 0146-0404

eISSN： 1552-5783
Vitreous lavage fluid and bronchoalveolar lavage fluid have equal diagnostic value in sarcoidosis Peer-reviewed

Kazuichi Maruyama, Tohru Inaba, Tsutomu Tamada, Toru Nakazawa

MEDICINE　95　(49)　e5531　2016/12

DOI： 10.1097/MD.0000000000005531 　

ISSN： 0025-7974

eISSN： 1536-5964
Eyeglasses-type retinal imaging system using MEMS scanner Peer-reviewed

T. Sasaki, T. Nakazawa, K. Hane

16th International Conference on Nanotechnology - IEEE NANO 2016　2018-July　923-924　2016/11/21
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI： 10.1109/NANO.2016.7751503 　

ISSN： 2160-5033

eISSN： 2160-5041
静岡県立子ども病院における虐待を疑われた小児の眼底所見

橋本清香, 西村香澄, 澤田麻友, 土屋陽子, 彦谷明子, 堀田喜裕, 中澤徹, 佐藤美保

日本眼科学会雑誌　120　(11)　802-802　2016/11
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
サルコイドーシス患者の硝子体液サンプルを用いた診断有用性と安全性について

丸山和一, 一迫玲, 中澤徹

日本眼科学会雑誌　120　(11)　808-809　2016/11
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric Glaucoma Peer-reviewed

Yukihiro Shiga, Hiroshi Kunikata, Naoko Aizawa, Naoki Kiyota, Yukiko Maiya, Yu Yokoyama, Kazuko Omodaka, Hidetoshi Takahashi, Tomoki Yasui, Keiichi Kato, Aiko Iwase, Toru Nakazawa

CURRENT EYE RESEARCH　41　(11)　1447-1453　2016/11

DOI： 10.3109/02713683.2015.1127974 　

ISSN： 0271-3683

eISSN： 1460-2202
The reduction of temporal optic nerve head microcirculation in autosomal dominant optic atrophy Peer-reviewed

Maki Inoue, Noriko Himori, Hiroshi Kunikata, Takayuki Takeshita, Naoko Aizawa, Yukihiro Shiga, Kazuko Omodaka, Koji M. Nishiguchi, Hidetoshi Takahashi, Toru Nakazawa

ACTA OPHTHALMOLOGICA　94　(7)　E580-E585　2016/11

DOI： 10.1111/aos.12999 　

ISSN： 1755-375X

eISSN： 1755-3768
Protective effects of sustained transscleral unoprostone delivery against retinal degeneration in S334ter rhodopsin mutant rats Peer-reviewed

Nobuhiro Nagai, Satoru Iwata, Hirokazu Kaji, Kaori Sampei, Yuki Katsukura, Hideyuki Onami, Matsuhiko Nishizawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS　104　(8)　1730-1737　2016/11

DOI： 10.1002/jbm.b.33522 　

ISSN： 1552-4973

eISSN： 1552-4981
Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography (vol 7, pg 3551, 2016) Peer-reviewed

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Yukihiro Shiga, Kazuko Omodaka, Naoko Aizawa, Yu Yokoyama, Noriko Himori, Shiho Kunimatsu-Sanuki, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

BIOMEDICAL OPTICS EXPRESS　7　(11)　4636-4638　2016/11

DOI： 10.1364/BOE.7.004636 　

ISSN： 2156-7085
Different etiologies and prognoses of optic neuritis in demyelinating diseases Peer-reviewed

Tetsuya Akaishi, Ichiro Nakashima, Takayuki Takeshita, Kimihiko Kaneko, Shunji Mugikura, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Toru Nakazawa, Masashi Aoki, Kazuo Fujihara

JOURNAL OF NEUROIMMUNOLOGY　299　152-157　2016/10

DOI： 10.1016/j.jneuroim.2016.09.007 　

ISSN： 0165-5728

eISSN： 1872-8421
Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis Peer-reviewed

Koji M. Nishiguchi, Yu Yokoyama, Yusuke Fujii, Kosuke Fujita, Yusuke Tomiyama, Ryo Kawasaki, Toshinori Furukawa, Fumiko Ono, Nobuhiro Shimozawa, Mutsumi Togo, Michihiro Suzuki, Toru Nakazawa

PLoS One　11　(10)　e0164899　2016/10

DOI： 10.1371/journal.pone.0164899 　

ISSN： 1932-6203
Heads-Up Macular Surgery with a 27-Gauge Microincision Vitrectomy System and Minimal Illumination Peer-reviewed

Hiroshi Kunikata, Toshiaki Abe, Toru Nakazawa

Case Reports in Ophthalmology　7　(3)　265-269　2016/09/09
Publisher: S. Karger AG
DOI： 10.1159/000452993 　

ISSN： 1663-2699

eISSN： 1663-2699
Anterior chamber aqueous flare and optic nerve microcirculation in eyes with rhegmatogenous retinal detachment Peer-reviewed

Rieko Yui, Hiroshi Kunikata, Naoko Aizawa, Toru Nakazawa

ACTA OPHTHALMOLOGICA　94　(6)　E520-E521　2016/09

DOI： 10.1111/aos.12970 　

ISSN： 1755-375X

eISSN： 1755-3768
The relationship between advanced glycation end products and ocular circulation in type 2 diabetes Peer-reviewed

Kazuki Hashimoto, Hiroshi Kunikata, Masayuki Yasuda, Azusa Ito, Naoko Aizawa, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Yoshimasa Takano, Koji M. Nishiguchi, Hideki Katagiri, Toru Nakazawa

JOURNAL OF DIABETES AND ITS COMPLICATIONS　30　(7)　1371-1377　2016/09

DOI： 10.1016/j.jdiacomp.2016.04.024 　

ISSN： 1056-8727

eISSN： 1873-460X
Transparent, resilient human amniotic membrane laminates for corneal transplantation Peer-reviewed

Takehiro Hariya, Yuji Tanaka, Shunji Yokokura, Toru Nakazawa

BIOMATERIALS　101　76-85　2016/09

DOI： 10.1016/j.biomaterials.2016.05.038 　

ISSN： 0142-9612

eISSN： 1878-5905
Comparing Trabeculectomy Outcomes between First and Second Operated Eyes: A Multicenter Study Peer-reviewed

Kentaro Iwasaki, Yoshihiro Takamura, Takashi Nishida, Akira Sawada, Keiichiro Iwao, Ayano Shinmura, Shiho Kunimatsu-Sanuki, Tetsuya Yamamoto, Hidenobu Tanihara, Kazuhisa Sugiyama, Toru Nakazawa, Masaru Inatani

PLOS ONE　11　(9)　e0162569　2016/09

DOI： 10.1371/journal.pone.0162569 　

ISSN： 1932-6203
Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography Peer-reviewed

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Yukihiro Shiga, Kazuko Omodaka, Naoko Aizawa, Yu Yokoyama, Noriko Himori, Shiho Kunimatsu-Sanuki, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

BIOMEDICAL OPTICS EXPRESS　7　(9)　3551-3573　2016/09

DOI： 10.1364/BOE.7.003551 　

ISSN： 2156-7085
Structure/function relationship between wide-scan binocular OCT images and the integrated visual field in glaucoma patients Peer-reviewed

Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　44　(6)　526-528　2016/08

DOI： 10.1111/ceo.12701 　

ISSN： 1442-6404

eISSN： 1442-9071
Quantification of the filtering bleb's structure with anterior segment optical coherence tomography Peer-reviewed

Taiki Kokubun, Hiroshi Kunikata, Satoru Tsuda, Noriko Himori, Kazuichi Maruyama, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　44　(6)　446-454　2016/08

DOI： 10.1111/ceo.12689 　

ISSN： 1442-6404

eISSN： 1442-9071
Current Status of Glaucoma-related Data Management and Efforts toward Data Standardization. Peer-reviewed

Kashiwag K, Aihara M, Inatani M, Iwase A, Kawase K, Sugiyama K, Nakazawa T, Nakamura M, Fukuchi T, Yoshitomi T, Araie M

Nippon Ganka Gakkai zasshi　120　(8)　540-547　2016/08

ISSN： 0029-0203

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Purpose: Ｗe conducted a survey to evaluate the current status of glaucoma-related medical data management and standardization, aiming to improve the development of glaucoma care and research in Japan. Materials and methods: The survey was performed as a paper-based questionnaire of 14 universities that both participate in the glaucoma-related data standardization committee, established by the Japan Glaucoma Society in 2014, and actively perform glaucoma care. Results: All enrolled university hospitals installed an electronic hospital information system and used any of three ophthalmology-limited electronic chart systems. However, only 30.8% of the hospitals established a data extraction system from an electronic medical chart system, and only 14.3% could practically apply medical data for secondary research purposes. In all, 35.7% of the hospitals operate a medical cooperation system with local medical institutions and 42.9% electronically managed medical data inside their departments. Conclusion: This survey clarified the current state of medical data management and standardization.
OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients Peer-reviewed

Naoko Takada, Kazuko Omodaka, Tsutomu Kikawa, Airi Takagi, Akiko Matsumoto, Yu Yokoyama, Yukihiro Shiga, Kazuichi Maruyama, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa

PLOS ONE　11　(8)　e0160226　2016/08

DOI： 10.1371/journal.pone.0160226 　

ISSN： 1932-6203
Measurement of Electroretinograms and Visually Evoked Potentials in Awake Moving Mice Peer-reviewed

Yusuke Tomiyama, Kosuke Fujita, Koji M. Nishiguchi, Naoyuki Tokashiki, Reiko Daigaku, Kitako Tabata, Eriko Sugano, Hiroshi Tomita, Toru Nakazawa

PLOS ONE　11　(6)　e0156927　2016/06

DOI： 10.1371/journal.pone.0156927 　

ISSN： 1932-6203
Transcriptome profiling of the rat retina after optic nerve transection Peer-reviewed

Masayuki Yasuda, Yuji Tanaka, Kazuko Omodaka, Koji M. Nishiguchi, Orie Nakamura, Satoru Tsuda, Toru Nakazawa

SCIENTIFIC REPORTS　6　28736　2016/06

DOI： 10.1038/srep28736 　

ISSN： 2045-2322
Real-time imaging of RGC death with a cell-impermeable nucleic acid dyeing compound after optic nerve crush in a murine model Peer-reviewed

Satoru Tsuda, Yuji Tanaka, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Azusa Ito, Toru Nakazawa

EXPERIMENTAL EYE RESEARCH　146　179-188　2016/05

DOI： 10.1016/j.exer.2016.03.017 　

ISSN： 0014-4835

eISSN： 1096-0007
MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study Peer-reviewed

Tetsuya Akaishi, Douglas Kazutoshi Sato, Ichiro Nakashima, Takayuki Takeshita, Toshiyuki Takahashi, Hiroshi Doi, Kazuhiro Kurosawa, Kimihiko Kaneko, Hiroshi Kuroda, Shuhei Nishiyama, Tatsuro Misu, Toru Nakazawa, Kazuo Fujihara, Masashi Aoki

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　87　(4)　446-+　2016/04

DOI： 10.1136/jnnp-2014-310206 　

ISSN： 0022-3050

eISSN： 1468-330X
Estimated retinal ganglion cells counts are a valuable parameter in normal tension glaucoma Peer-reviewed

Mai Yamazaki, Kazuko Omodaka, Naoko Aizawa, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　44　(3)　207-209　2016/04

DOI： 10.1111/ceo.12656 　

ISSN： 1442-6404

eISSN： 1442-9071
Lesion length of optic neuritis impacts visual prognosis in neuromyelitis optica Peer-reviewed

Tetsuya Akaishi, Ichiro Nakashima, Takayuki Takeshita, Shunji Mugikura, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Shuhei Nishiyama, Kazuhiro Kurosawa, Tatsuro Misu, Toru Nakazawa, Masashi Aoki, Kazuo Fujihara

JOURNAL OF NEUROIMMUNOLOGY　293　28-33　2016/04

DOI： 10.1016/j.jneuroim.2016.02.004 　

ISSN： 0165-5728

eISSN： 1872-8421
Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography Peer-reviewed

Kazuko Omodaka, Seri Takahashi, Akiko Matsumoto, Shigeto Maekawa, Tsutomu Kikawa, Noriko Himori, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Akiba, Toru Nakazawa

PLOS ONE　11　(4)　e0153707　2016/04

DOI： 10.1371/journal.pone.0153707 　

ISSN： 1932-6203
Topical ocular dexamethasone decreases intraocular pressure and body weight in rats Peer-reviewed

Kota Sato, Koji M. Nishiguchi, Kazuichi Maruyama, Satoru Moritoh, Kosuke Fujita, Yoshikazu Ikuta, Hitoshi Kasai, Toru Nakazawa

Journal of Negative Results in BioMedicine　15　(1)　5　2016/03/12
Publisher: BioMed Central Ltd.
DOI： 10.1186/s12952-016-0048-x 　

ISSN： 1477-5751
Estimation of the Disc Damage Likelihood Scale in primary open-angle glaucoma: the Glaucoma Stereo Analysis Study Peer-reviewed

Yasushi Kitaoka, Masaki Tanito, Yu Yokoyama, Koji Nitta, Maki Katai, Kazuko Omodaka, Toru Nakazawa

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　254　(3)　523-528　2016/03

DOI： 10.1007/s00417-015-3239-0 　

ISSN： 0721-832X

eISSN： 1435-702X
Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations Peer-reviewed

Zheng Wang, Aritoshi Iida, Noriko Miyake, Koji M. Nishiguchi, Kosuke Fujita, Toru Nakazawa, Abdulrahman Alswaid, Mohammed A. Albalwi, Ok-Hwa Kim, Tae-Joon Cho, Gye-Yeon Lim, Bertrand Isidor, Albert David, Cecilie F. Rustad, Else Merckoll, Jostein Westvik, Eva-Lena Stattin, Giedre Grigelioniene, Ikuyo Kou, Masahiro Nakajima, Hirohumi Ohashi, Sarah Smithson, Naomichi Matsumoto, Gen Nishimura, Shiro Ikegawa

PLOS ONE　11　(3)　e0150555　2016/03

DOI： 10.1371/journal.pone.0150555 　

ISSN： 1932-6203
Retinal Pigment Epithelium Hyperplasia After Unsuccessful Surgery for Macular Hole Peer-reviewed

Naoto Imadome, Hiroshi Kunikata, Shunichiro Asano, Toru Nakazawa

OPHTHALMIC SURGERY LASERS & IMAGING RETINA　47　(3)　284-286　2016/03

DOI： 10.3928/23258160-20160229-13 　

ISSN： 2325-8160

eISSN： 2325-8179
The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma Peer-reviewed

Noriko Himori, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Hidetoshi Takahashi, Toru Nakazawa

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　254　(2)　333-341　2016/02

DOI： 10.1007/s00417-015-3203-z 　

ISSN： 0721-832X

eISSN： 1435-702X
Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Fumihiko Nitta, Yukihiro Shiga, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

PLOS ONE　11　(2)　e0148812　2016/02

DOI： 10.1371/journal.pone.0148812 　

ISSN： 1932-6203
Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury Peer-reviewed

Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY　854　471-477　2016

DOI： 10.1007/978-3-319-17121-0_63 　

ISSN： 0065-2598
Recent clinical applications of laser speckle flowgraphy in eyes with retinal disease Peer-reviewed

Hiroshi Kunikata, Toru Nakazawa

Asia-Pacific Journal of Ophthalmology　5　(2)　151-158　2016
Publisher: Asia-Pacific Academy of Ophthalmology
DOI： 10.1097/APO.0000000000000160 　

ISSN： 2162-0989

eISSN： 2162-0989
Ocular blood flow and influencing factors for glaucoma Peer-reviewed

Toru Nakazawa

Asia-Pacific Journal of Ophthalmology　5　(1)　38-44　2016
Publisher: Asia-Pacific Academy of Ophthalmology
DOI： 10.1097/APO.0000000000000183 　

ISSN： 2162-0989
Large vessel area of the optic nerve head, measured with laser speckle flowgraphy, is significantly reduced in eyes with preperimetric glaucoma Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Hidetoshi Takahashi, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(9)　841-843　2015/12

DOI： 10.1111/ceo.12562 　

ISSN： 1442-6404

eISSN： 1442-9071
In vivo cellular imaging of various stress/response pathways using AAV following axonal injury in mice Peer-reviewed

Kosuke Fujita, Koji M. Nishiguchi, Yu Yokoyama, Yusuke Tomiyama, Satoru Tsuda, Masayuki Yasuda, Shigeto Maekawa, Toru Nakazawa

SCIENTIFIC REPORTS　5　18141　2015/12

DOI： 10.1038/srep18141 　

ISSN： 2045-2322
First case of primary intraocular natural killer t-cell lymphoma Peer-reviewed

Kazuichi Maruyama, Hiroshi Kunikata, Sunao Sugita, Manabu Mochizuki, Ryo Ichinohasama, Toru Nakazawa

BMC OPHTHALMOLOGY　15　169　2015/11

DOI： 10.1186/s12886-015-0158-0 　

ISSN： 1471-2415
Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma Peer-reviewed

Megumi Honjo, Kazuko Omodaka, Tatsuro Ishizaki, Shinji Ohkubo, Makoto Araie, Toru Nakazawa

PLOS ONE　10　(10)　e0141293　2015/10

DOI： 10.1371/journal.pone.0141293 　

ISSN： 1932-6203
Association between histological findings and polarization-sensitive optical coherence tomography analysis of a post-trabeculectomy human eye Peer-reviewed

Satoru Tsuda, Hiroshi Kunikata, Masahiro Yamanari, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(7)　685-688　2015/09

DOI： 10.1111/ceo.12522 　

ISSN： 1442-6404

eISSN： 1442-9071
Application of clotrimazole via a novel controlled release device provides potent retinal protection Peer-reviewed

Zhaleh Kashkouli Nezhad, Nobuhiro Nagai, Kotaro Yamamoto, Hirokazu Kaji, Matsuhiko Nishizawa, Hideyuki Saya, Toru Nakazawa, Toshiaki Abe

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　26　(9)　230　2015/09

DOI： 10.1007/s10856-015-5561-9 　

ISSN： 0957-4530

eISSN： 1573-4838
Characteristics of patients with primary open angle glaucoma and normal tension glaucoma at a university hospital: A cross-sectional retrospective study Peer-reviewed

Yu Yokoyama, Kazuichi Maruyama, Hideyuki Konno, Sayaka Hashimoto, Mai Takahashi, Hiroko Kayaba, Taiki Kokubun, Toru Nakazawa

BMC Research Notes　8　(1)　360　2015/08/19
Publisher: BioMed Central Ltd.
DOI： 10.1186/s13104-015-1339-x 　

ISSN： 1756-0500
The relationship between laser speckle flowgraphy-measured optic disc microcirculation and postoperative visual recovery in rhegmatogenous retinal detachment Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Fumihiko Nitta, Toru Nakazawa

ACTA OPHTHALMOLOGICA　93　(5)　E397-E399　2015/08

DOI： 10.1111/aos.12586 　

ISSN： 1755-375X

eISSN： 1755-3768
Topographical Correlation Between Macular Layer Thickness and Clockwise Circumpapillary Retinal Nerve Fiber Layer Sectors in Patients with Normal Tension Glaucoma Peer-reviewed

Kazuko Omodaka, Yu Yokoyama, Yukihiro Shiga, Maki Inoue, Seri Takahashi, Satoru Tsuda, Kazuichi Maruyama, Toru Nakazawa

CURRENT EYE RESEARCH　40　(7)　744-751　2015/07

DOI： 10.3109/02713683.2014.956371 　

ISSN： 0271-3683

eISSN： 1460-2202
Characteristic correlations of the structure-function relationship in different glaucomatous disc types Peer-reviewed

Kazuko Omodaka, Naoko Takada, Takuhiro Yamaguchi, Hidetoshi Takahashi, Makoto Araie, Toru Nakazawa

JAPANESE JOURNAL OF OPHTHALMOLOGY　59　(4)　223-229　2015/07

DOI： 10.1007/s10384-015-0379-z 　

ISSN： 0021-5155

eISSN： 1613-2246
出血型網膜細動脈瘤の治療後視力に関する臨床研究 Peer-reviewed

浅野俊文, 針谷威寛, 金澤紘子, 中澤徹, 佐藤肇

日本眼科学会雑誌　119　(6)　387-394　2015/06
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Bruch's Membrane Opening-Based Neuroretinal Rim Width and Retinal Nerve Fibre Layer Thickness in a Normal Japanese Population. A Multi-Centre Study Peer-reviewed

Balwantray C. Chauhan, Masanori Hangai, Aiko Iwase, Toru Nakazawa, Kazuhisa Sugiyama, Hidenobu Tanihara, Goji Tomita, Yasuo Yanagi, Claude F. Burgoyne, Makoto Araie

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
[Clinical Research of Factors Influencing Visual Outcomes in Patients with Hemorrhagic Retinal Arterial Macroaneurysms]. Peer-reviewed

Toshifumi Asano, Takehiro Hariya, Hiroko Kanazawa, Toru Nakazawa, Hajime Sato

Nippon Ganka Gakkai zasshi　119　(6)　387-94　2015/06

ISSN： 0029-0203

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PURPOSE: To identify factors influencing visual outcomes in patients with hemorrhagic retinal arterial macroaneurysms (MA). METHODS: We retrospectively reviewed the charts of 13 eyes of 13 patients with hemorrhagic MAs. We evaluated factors. including age, blood pressure, ocular perfusion pressure, optic disc-MA distance, MA-fovea distance, the area of the hemorrhage, the time between onset and treatment, initial visual acuity, and the presence of subfoveal hemorrhage. Additionally, we measured the retinal cross-sectional area of the fovea with optical coherence tomography (OCT). RESULTS: There were significant differences in MA-fovea distance, area of the subretinal hemorrhage, and visual outcome in eyes with or without subfoveal hemorrhage (p < 0.05). Spearman's correlation analysis showed a significant negative correlation between visual outcome (logMAR) and disc-MA distance (rS = -0.61, p < 0.05), as well as MA-fovea distance (rS = -0.79, p < 0.01). A multivariate analysis showed an independent negative correlation between visual outcome and MA-fovea distance (Stdβ = -0.66, t = 3.21, p < 0.01). In addition, there was a significant positive correlation between MA-fovea distance and the affected-/healthy-eye ratio of outer-retinal-layer cross-sectional area in the fovea (rS = 0.64, p < 0.05). The cutoff value of MA-fovea distance for subfoveal hemorrhage was 3000 microns, with a sensitivity of 100, specificity of 77.8, positive predictive value of 66.7 and a negative predictive value of 100. CONCLUSIONS: When hemorrhagic MAs are located closer to the fovea, the outer retinal layer is more severely affected and visual outcomes are poorer. Subfoveal hemorrhage should be considered even when it is not apparent, especially when the hemorrhagic MA is located within 3000 microns of the fovea.
Intraoperative Optical Coherence Tomography-Assisted 27-Gauge Vitrectomy in Eyes with Vitreoretinal Diseases Peer-reviewed

Hiroshi Kunikata, Toru Nakazawa

Case Reports in Ophthalmology　6　(2)　216-222　2015/05/05
Publisher: S. Karger AG
DOI： 10.1159/000437014 　

ISSN： 1663-2699

eISSN： 1663-2699
Comparison of outcome of subtenon and intravitreal injection of triamcinolone acetonide for diabetic macular edema

Naoto Imadome, Hiroshi Kunikata, Shunichiro Asano, Hideyuki Konno, Takeshi Izumi, Toru Nakazawa

Japanese Journal of Clinical Ophthalmology　69　(5)　705-710　2015/05/01

ISSN： 0370-5579
糖尿病黄斑浮腫に対するトリアムシノロンアセトニド局所投与の効果比較

今留尚人, 國方彦志, 浅野俊一郎, 今野瑛之, 泉武, 中澤徹

臨床眼科　69　(5)　705-710　2015/05
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
[Designation criteria for Leber's hereditary optic neuropathy]. Peer-reviewed

Nakamura M, Mimura O, Wakakura M, Inatani M, Nakazawa T, Shiraga F

Nippon Ganka Gakkai zasshi　119　(5)　339-346　2015/05
Publisher:
ISSN： 0029-0203
Regional correlation of macular areas and visual acuity in patients with open-angle glaucoma Peer-reviewed

Kazuko Omodaka, Takeshi Yabana, Naoko Takada, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(3)　279-282　2015/04

DOI： 10.1111/ceo.12403 　

ISSN： 1442-6404

eISSN： 1442-9071
Regional susceptibility of the optic disc to retinal nerve fiber layer thinning in different optic disc types of eyes with normal tension glaucoma Peer-reviewed

Naoko Takada, Kazuko Omodaka, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(3)　291-293　2015/04

DOI： 10.1111/ceo.12429 　

ISSN： 1442-6404

eISSN： 1442-9071
Molecular, anatomical and functional changes in the retinal ganglion cells after optic nerve crush in mice Peer-reviewed

Masayoshi Yukita, Shigeki Machida, Koji M. Nishiguchi, Satoru Tsuda, Yu Yokoyama, Masayuki Yasuda, Kazuichi Maruyama, Toru Nakazawa

DOCUMENTA OPHTHALMOLOGICA　130　(2)　149-156　2015/04

DOI： 10.1007/s10633-014-9478-2 　

ISSN： 0012-4486

eISSN： 1573-2622
3D Evaluation of the Lamina Cribrosa with Swept-Source Optical Coherence Tomography in Normal Tension Glaucoma Peer-reviewed

Kazuko Omodaka, Takaaki Horii, Seri Takahashi, Tsutomu Kikawa, Akiko Matsumoto, Yukihiro Shiga, Kazuichi Maruyama, Tetsuya Yuasa, Masahiro Akiba, Toru Nakazawa

PLOS ONE　10　(4)　e0122347　2015/04

DOI： 10.1371/journal.pone.0122347 　

ISSN： 1932-6203
Relationship of Skin Autofluorescence to Severity of Retinopathy in Type 2 Diabetes Peer-reviewed

Masayuki Yasuda, Masahiko Shimura, Hiroshi Kunikata, Hiroko Kanazawa, Kanako Yasuda, Yuji Tanaka, Hideyuki Konno, Mai Takahashi, Taiki Kokubun, Kazuichi Maruyama, Noriko Sato, Masako Kakizaki, Mari Sato, Ichiro Tsuji, Toshio Miyata, Toru Nakazawa

CURRENT EYE RESEARCH　40　(3)　338-345　2015/03

DOI： 10.3109/02713683.2014.918152 　

ISSN： 0271-3683

eISSN： 1460-2202
Efficacy of Chandelier Illumination for Combined Cataract Operation and Penetrating Keratoplasty Peer-reviewed

Shunji Yokokura, Takehiro Hariya, Megumi Uematsu, Yasuhiko Meguro, Wataru Kobayashi, Kohji Nishida, Toru Nakazawa

CORNEA　34　(3)　275-278　2015/03

DOI： 10.1097/ICO.0000000000000319 　

ISSN： 0277-3740

eISSN： 1536-4798
[Aiming for zero blindness]. Peer-reviewed

Nakazawa T

Nippon Ganka Gakkai zasshi　119　(3)　168-93; discussion 194　2015/03

ISSN： 0029-0203
Two percent ethylenediaminetetraacetic acid chelation treatment for band-Shaped keratopathy, without blunt scratching after removal of the corneal epithelium Peer-reviewed

Wataru Kobayashi, Shunji Yokokura, Takehiro Hariya, Toru Nakazawa

Clinical Ophthalmology　9　217-223　2015/02/02
Publisher: Dove Medical Press Ltd
DOI： 10.2147/OPTH.S75938 　

ISSN： 1177-5483 1177-5467
Relationship of Ocular Microcirculation, Measured by Laser Speckle Flowgraphy, and Silent Brain Infarction in Primary Aldosteronism Peer-reviewed

Hiroshi Kunikata, Naoko Aizawa, Masataka Kudo, Shunji Mugikura, Fumihiko Nitta, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Fumitoshi Satoh, Hidetoshi Takahashi, Sadayoshi Ito, Shoki Takahashi, Toru Nakazawa

PLOS ONE　10　(2)　e0117452　2015/02

DOI： 10.1371/journal.pone.0117452 　

ISSN： 1932-6203
Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment Peer-reviewed

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Yukihiro Shiga, Kazuko Omodaka, Yu Yokoyama, Noriko Himori, Morin Ryu, Shiho Kunimatsu-Sanuki, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

BIOMEDICAL OPTICS EXPRESS　6　(2)　369-389　2015/02

DOI： 10.1364/BOE.6.000369 　

ISSN： 2156-7085
Regional structural vulnerability of the macula in patients with normal tension glaucoma Peer-reviewed

Kazuko Omodaka, Naoko Takada, Hidetoshi Takahashi, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(1)　89-90　2015/01

DOI： 10.1111/ceo.12363 　

ISSN： 1442-6404

eISSN： 1442-9071
Analysis of higher-order aberrations in eyes having undergone intraocular lens suturing Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Naoyuki Maeda, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(1)　92-94　2015/01

DOI： 10.1111/ceo.12366 　

ISSN： 1442-6404

eISSN： 1442-9071
Assessment of Short-Term Changes in Optic Nerve Head Hemodynamics in Hyperoxic Conditions with Laser Speckle Flowgraphy Peer-reviewed

Yukihiro Shiga, Marika Sato, Kazuichi Maruyama, Shin Takayama, Kazuko Omodaka, Noriko Himori, Hiroshi Kunikata, Toru Nakazawa

CURRENT EYE RESEARCH　40　(10)　1055-1062　2015

DOI： 10.3109/02713683.2014.971934 　

ISSN： 0271-3683

eISSN： 1460-2202
An assessment of driving fitness in patients with visual impairment to understand the elevated risk of motor vehicle accidents Peer-reviewed

Shiho Kunimatsu-Sanuki, Aiko Iwase, Makoto Araie, Yuki Aoki, Takeshi Hara, Toru Nakazawa, Takuhiro Yamaguchi, Hiroshi Ono, Tomoyuki Sanuki, Makoto Itoh

BMJ OPEN　5　(2)　e006379　2015

DOI： 10.1136/bmjopen-2014-006379 　

ISSN： 2044-6055
Correlation of Papillomacular Nerve Fiber Bundle Thickness with Central Visual Function in Open-Angle Glaucoma Peer-reviewed

Wataru Kobayashi, Hiroshi Kunikata, Kazuko Omodaka, Kyousuke Togashi, Morin Ryu, Masahiro Akiba, Gaku Takeuchi, Tetsuya Yuasa, Toru Nakazawa

JOURNAL OF OPHTHALMOLOGY　2015　460918　2015

DOI： 10.1155/2015/460918 　

ISSN： 2090-004X

eISSN： 2090-0058
Ocular Blood Flow and Visual Function Peer-reviewed

Goji Tomita, David Huang, Colm O'Brien, Ki Ho Park, Toru Nakazawa

BIOMED RESEARCH INTERNATIONAL　2015　319254　2015

DOI： 10.1155/2015/319254 　

ISSN： 2314-6133

eISSN： 2314-6141
Pulse-Waveform Analysis of Normal Population using Laser Speckle Flowgraphy Peer-reviewed

Satoru Tsuda, Hiroshi Kunikata, Masahiko Shimura, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Yu Yokoyama, Toru Nakazawa

CURRENT EYE RESEARCH　39　(12)　1207-1215　2014/12

DOI： 10.3109/02713683.2014.905608 　

ISSN： 0271-3683

eISSN： 1460-2202
Usefulness of novel laser speckle flowgraphy-derived variables of the large vessel area in the optic nerve head in normal tension glaucoma Peer-reviewed

Shigeto Maekawa, Yukihiro Shiga, Ryo Kawasaki, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　42　(9)　887-889　2014/12

DOI： 10.1111/ceo.12354 　

ISSN： 1442-6404

eISSN： 1442-9071
Artemin Augments Survival and Axon Regeneration in Axotomized Retinal Ganglion Cells Peer-reviewed

Kazuko Omodaka, Takuji Kurimoto, Orie Nakamura, Kota Sato, Masayuki Yasuda, Yuji Tanaka, Noriko Himori, Yu Yokoyama, Toru Nakazawa

JOURNAL OF NEUROSCIENCE RESEARCH　92　(12)　1637-1646　2014/12

DOI： 10.1002/jnr.23449 　

ISSN： 0360-4012

eISSN： 1097-4547
Laser Speckle and Hydrogen Gas Clearance Measurements of Optic Nerve Circulation in Albino and Pigmented Rabbits With or Without Optic Disc Atrophy Peer-reviewed

Naoko Aizawa, Fumihiko Nitta, Hiroshi Kunikata, Tetsuya Sugiyama, Tsunehiko Ikeda, Makoto Araie, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　55　(12)　7991-7996　2014/12

DOI： 10.1167/iovs.14-15373 　

ISSN： 0146-0404

eISSN： 1552-5783
Characteristics of uveitic glaucoma and evaluation of its surgical treatment Peer-reviewed

Ai Shimizu, Kazuichi Maruyama, Y. Yokoyama, Satoru Tsuda, Morin Ryu, Toru Nakazawa

Clinical Ophthalmology　8　2383-2389　2014/11/26
Publisher: Dove Medical Press Ltd
DOI： 10.2147/OPTH.S72383 　

ISSN： 1177-5483 1177-5467
Usefulness of Laser Speckle Flowgraphy for the Assessment of Ocular Blood Flow in Extracranial-Intracranial Bypass Peer-reviewed

Shunsuke Omodaka, Hidenori Endo, Hiroshi Doi, Hiroaki Shimizu, Miki Fujimura, Naoko Aizawa, Toru Nakazawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　23　(10)　E445-E448　2014/11

DOI： 10.1016/j.jstrokecerebrovasdis.2014.06.021 　

ISSN： 1052-3057

eISSN： 1532-8511
The Novel Rho Kinase (ROCK) Inhibitor K-115: A New Candidate Drug for Neuroprotective Treatment in Glaucoma Peer-reviewed

Kotaro Yamamoto, Kazuichi Maruyama, Noriko Himori, Kazuko Omodaka, Yu Yokoyama, Yukihiro Shiga, Ryu Morin, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　55　(11)　7126-7136　2014/11

DOI： 10.1167/iovs.13-13842 　

ISSN： 0146-0404

eISSN： 1552-5783
Retinal transcriptome profiling at transcription start sites: a cap analysis of gene expression early after axonal injury Peer-reviewed

Masayuki Yasuda, Yuji Tanaka, Koji M. Nishiguchi, Morin Ryu, Satoru Tsuda, Kazuichi Maruyama, Toru Nakazawa

BMC GENOMICS　15　982　2014/11

DOI： 10.1186/1471-2164-15-982 　

ISSN： 1471-2164
Experimental Application of Piezoelectric Actuator-Driven Pulsed Water Jets in Retinal Vascular Surgery Peer-reviewed

Hiroshi Kunikata, Yuji Tanaka, Naoko Aizawa, Atsuhiro Nakagawa, Teiji Tominaga, Toru Nakazawa

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY　3　(6)　10　2014/11

DOI： 10.1167/tvst.3.6.10 　

ISSN： 2164-2591
Retrospective Comparison of 25- and 23-Gauge Microincision Vitrectomy Surgery and 20-Gauge Vitrectomy for the Repair of Macular Hole Retinal Detachment. Peer-reviewed

Kobayashi W, Kunikata H, Abe T, Nakazawa T

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)　3　(6)　331-336　2014/11

DOI： 10.1097/APO.0000000000000031 　
A Platform for Controlled Dual-Drug Delivery to the Retina: Protective Effects against Light-Induced Retinal Damage in Rats Peer-reviewed

Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe

ADVANCED HEALTHCARE MATERIALS　3　(10)　1555-1560　2014/10

DOI： 10.1002/adhm.201400114 　

ISSN： 2192-2640

eISSN： 2192-2659
Neuroprotective effect against axonal damage-induced retinal ganglion cell death in apolipoprotein E-deficient mice through the suppression of kainate receptor signaling Peer-reviewed

Kazuko Omodaka, Koji M. Nishiguchi, Masayuki Yasuda, Yuji Tanaka, Kota Sato, Orie Nakamura, Kazuichi Maruyama, Toru Nakazawa

BRAIN RESEARCH　1586　203-212　2014/10

DOI： 10.1016/j.brainres.2014.08.053 　

ISSN： 0006-8993

eISSN： 1872-6240
Optic disc microcirculation in superior segmental optic hypoplasia assessed with laser speckle flowgraphy Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Kazuko Omodaka, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　42　(7)　702-704　2014/09

DOI： 10.1111/ceo.12313 　

ISSN： 1442-6404

eISSN： 1442-9071
Critical Neuroprotective Roles of Heme Oxygenase-1 Induction Against Axonal Injury-Induced Retinal Ganglion Cell Death Peer-reviewed

Noriko Himori, Kazuichi Maruyama, Kotaro Yamamoto, Masayuki Yasuda, Morin Ryu, Kazuko Omodaka, Yukihiro Shiga, Yuji Tanaka, Toru Nakazawa

JOURNAL OF NEUROSCIENCE RESEARCH　92　(9)　1134-1142　2014/09

DOI： 10.1002/jnr.23398 　

ISSN： 0360-4012

eISSN： 1097-4547
The role of calpain in an in vivo model of oxidative stress-induced retinal ganglion cell damage Peer-reviewed

Yu Yokoyama, Kazuichi Maruyama, Kotaro Yamamoto, Kazuko Omodaka, Masayuki Yasuda, Noriko Himori, Morin Ryu, Koji M. Nishiguchi, Toru Nakazawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　451　(4)　510-515　2014/09

DOI： 10.1016/j.bbrc.2014.08.009 　

ISSN： 0006-291X

eISSN： 1090-2104
Correlation between structure/function and optic disc microcirculation in myopic glaucoma, measured with laser speckle flowgraphy Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Yu Yokoyama, Kazuko Omodaka, Toru Nakazawa

BMC OPHTHALMOLOGY　14　113　2014/09

DOI： 10.1186/1471-2415-14-113 　

ISSN： 1471-2415
Age Differences in Sarcoidosis Patients with Posterior Ocular Lesions Peer-reviewed

Kenji Nagata, Kazuichi Maruyama, Sunao Sugita, Urara Fukuchi, Yukiko Terada, Atsuko Ishizuka, Toru Nakazawa, Manabu Mochizuki, Shigeru Kinoshita

OCULAR IMMUNOLOGY AND INFLAMMATION　22　(4)　257-262　2014/08

DOI： 10.3109/09273948.2013.855796 　

ISSN： 0927-3948

eISSN： 1744-5078
The Effect of Podoplanin Inhibition on Lymphangiogenesis Under Pathological Conditions Peer-reviewed

Yuko Maruyama, Kazuichi Maruyama, Yukinari Kato, Kentaro Kajiya, Satoru Moritoh, Kotaro Yamamoto, Yuko Matsumoto, Mika Sawane, Dontscho Kerjaschki, Toru Nakazawa, Shigeru Kinoshita

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　55　(8)　4813-4822　2014/08

DOI： 10.1167/iovs.13-13711 　

ISSN： 0146-0404

eISSN： 1552-5783
Ophthalmologic Examinations in Areas of Miyagi Prefecture Affected by the Great East Japan Earthquake Peer-reviewed

Hiroshi Doi, Hiroshi Kunikata, Keiichi Kato, Toru Nakazawa

JAMA OPHTHALMOLOGY　132　(7)　874-876　2014/07

DOI： 10.1001/jamaophthalmol.2014.849 　

ISSN： 2168-6165

eISSN： 2168-6173
Ophthalmologic Examinations in Areas of Miyagi Prefecture Affected by the Great East Japan Earthquake Peer-reviewed

Hiroshi Doi, Hiroshi Kunikata, Keiichi Kato, Toru Nakazawa

JAMA OPHTHALMOLOGY　132　(7)　874-876　2014/07

DOI： 10.1001/jamaophthalmol.2014.849 　

ISSN： 2168-6165

eISSN： 2168-6173
Relative Flow Volume, a Novel Blood Flow Index in the Human Retina Derived From Laser Speckle Flowgraphy Peer-reviewed

Yukihiro Shiga, Toshifumi Asano, Hiroshi Kunikata, Fumihiko Nitta, Hajime Sato, Toru Nakazawa, Masahiko Shimura

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　55　(6)　3899-3904　2014/06

DOI： 10.1167/iovs.14-14116 　

ISSN： 0146-0404

eISSN： 1552-5783
Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study Peer-reviewed

Yu Yokoyama, Masaki Tanito, Koji Nitta, Maki Katai, Yasushi Kitaoka, Kazuko Omodaka, Satoru Tsuda, Toshiaki Nakagawa, Toru Nakazawa

PLOS ONE　9　(6)　e99138　2014/06

DOI： 10.1371/journal.pone.0099138 　

ISSN： 1932-6203
Calcium and calpain activation Peer-reviewed

Morin Ryu, Toru Nakazawa

Neuroprotection and Neuroregeneration for Retinal Diseases　13-24　2014/05/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54965-9_2 　
Profiles of Extracellular miRNAs in the Aqueous Humor of Glaucoma Patients Assessed with a Microarray System Peer-reviewed

Yuji Tanaka, Satoru Tsuda, Hiroshi Kunikata, Junko Sato, Taiki Kokubun, Masayuki Yasuda, Koji M. Nishiguchi, Toshifumi Inada, Toru Nakazawa

SCIENTIFIC REPORTS　4　5089　2014/05

DOI： 10.1038/srep05089 　

ISSN： 2045-2322
Profiles of Extracellular miRNAs in the Aqueous Humor of Glaucoma Patients Assessed with a Microarray System Peer-reviewed

Yuji Tanaka, Satoru Tsuda, Hiroshi Kunikata, Junko Sato, Taiki Kokubun, Masayuki Yasuda, Koji M. Nishiguchi, Toshifumi Inada, Toru Nakazawa

SCIENTIFIC REPORTS　4　2014/05

DOI： 10.1038/srep05089 　

ISSN： 2045-2322
Correlation of magnetic resonance imaging optic nerve parameters to optical coherence tomography and the visual field in glaucoma Peer-reviewed

Kazuko Omodaka, Takaki Murata, Shiho Sato, Mai Takahashi, Yasuko Tatewaki, Tatsuo Nagasaka, Hiroshi Doi, Makoto Araie, Shoki Takahashi, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　42　(4)　360-368　2014/05

DOI： 10.1111/ceo.12237 　

ISSN： 1442-6404

eISSN： 1442-9071
Role of the Vision Van, a mobile ophthalmic outpatient clinic, in the Great East Japan Earthquake Peer-reviewed

Kenya Yuki, Toru Nakazawa, Daijiro Kurosaka, Tsunehiko Yoshida, Eduardo C. Alfonso, Richard K. Lee, Shigeru Takano, Kazuo Tsubota

Clinical Ophthalmology　8　691-696　2014/04/07
Publisher: Dove Medical Press
DOI： 10.2147/OPTH.S58887 　

ISSN： 1177-5483 1177-5467
Correlation between optic disc microcirculation in glaucoma measured with laser speckle flowgraphy and fluorescein angiography, and the correlation with mean deviation Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Yu Yokoyama, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　42　(3)　293-294　2014/04

DOI： 10.1111/ceo.12130 　

ISSN： 1442-6404

eISSN： 1442-9071
【「眼疾患メカニズムの新しい理解」をより理解するために失明ゼロを目指して】「失明ゼロを目指して」をより理解するために

中澤徹, 谷戸正樹

日本の眼科　85　(3)　277-283　2014/03
Publisher: (公社)日本眼科医会
ISSN： 0285-1326
RNA Sequence Reveals Mouse Retinal Transcriptome Changes Early after Axonal Injury Peer-reviewed

Masayuki Yasuda, Yuji Tanaka, Morin Ryu, Satoru Tsuda, Toru Nakazawa

PLOS ONE　9　(3)　e93258　2014/03

DOI： 10.1371/journal.pone.0093258 　

ISSN： 1932-6203
A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye Peer-reviewed

Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yumi Ishikawa, Matsuhiko Nishizawa, Noriko Osumi, Toru Nakazawa, Toshiaki Abe

ACTA BIOMATERIALIA　10　(2)　680-687　2014/02

DOI： 10.1016/j.actbio.2013.11.004 　

ISSN： 1742-7061

eISSN： 1878-7568
The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects Peer-reviewed

Shin Takayama, Yukihiro Shiga, Taiki Kokubun, Hideyuki Konno, Noriko Himori, Morin Ryu, Takehiro Numata, Soichiro Kaneko, Hitoshi Kuroda, Junichi Tanaka, Seiki Kanemura, Tadashi Ishii, Nobuo Yaegashi, Toru Nakazawa

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE　2014　586857　2014

DOI： 10.1155/2014/586857 　

ISSN： 1741-427X

eISSN： 1741-4288
25-Gauge Microincision Vitrectomy to Treat Vitreoretinal Disease in Glaucomatous Eyes after Trabeculectomy Peer-reviewed

Hiroshi Kunikata, Naoko Aizawa, Nobuo Fuse, Toshiaki Abe, Toru Nakazawa

JOURNAL OF OPHTHALMOLOGY　2014　306814　2014

DOI： 10.1155/2014/306814 　

ISSN： 2090-004X

eISSN： 2090-0058
The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy. International-journal Peer-reviewed

Fumihiko Nitta, Hiroshi Kunikata, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Toru Nakazawa

Clinical ophthalmology (Auckland, N.Z.)　8　1119-27　2014

DOI： 10.2147/OPTH.S62022 　

ISSN： 1177-5467

More details Close

BACKGROUND: This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy. METHODS: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB. RESULTS: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH. CONCLUSION: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.
Molecular and Cellular Features of Murine Craniofacial and Trunk Neural Crest Cells as Stem Cell-Like Cells Peer-reviewed

Kunie Hagiwara, Takeshi Obayashi, Nobuyuki Sakayori, Emiko Yamanishi, Ryuhei Hayashi, Noriko Osumi, Toru Nakazawa, Kohji Nishida

PLOS ONE　9　(1)　e84072　2014/01

DOI： 10.1371/journal.pone.0084072 　

ISSN： 1932-6203
Predicting Visual Outcomes for Macula-Off Rhegmatogenous Retinal Detachment with Optical Coherence Tomography Peer-reviewed

Noriyuki Suzuki, Hiroshi Kunikata, Naoko Aizawa, Toshiaki Abe, Toru Nakazawa

JOURNAL OF OPHTHALMOLOGY　2014　269837　2014

DOI： 10.1155/2014/269837 　

ISSN： 2090-004X

eISSN： 2090-0058
Correlation of Optic Nerve Microcirculation with Papillomacular Bundle Structure in Treatment Naive Normal Tension Glaucoma Peer-reviewed

Wataru Kobayashi, Hiroshi Kunikata, Kazuko Omodaka, Kyousuke Togashi, Morin Ryu, Masahiro Akiba, Gaku Takeuchi, Tetsuya Yuasa, Toru Nakazawa

JOURNAL OF OPHTHALMOLOGY　2014　468908　2014

DOI： 10.1155/2014/468908 　

ISSN： 2090-004X

eISSN： 2090-0058
Development of azo-based fluorescent probes to detect different levels of hypoxia Peer-reviewed

Wen Piao, Satoru Tsuda, Yuji Tanaka, Satoshi Maeda, Fengyi Liu, Shodai Takahashi, Yu Kushida, Toru Komatsu, Tasuku Ueno, Takuya Terai, Toru Nakazawa, Masanobu Uchiyama, Keiji Morokuma, Tetsuo Nagano, Kenjiro Hanaoka

Angewandte Chemie - International Edition　52　(49)　13028-13032　2013/12/02

DOI： 10.1002/anie.201305784 　

ISSN： 1433-7851 1521-3773
Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death Peer-reviewed

Noriko Himori, Kotaro Yamamoto, Kazuichi Maruyama, Morin Ryu, Keiko Taguchi, Masayuki Yamamoto, Toru Nakazawa

JOURNAL OF NEUROCHEMISTRY　127　(5)　669-680　2013/12

DOI： 10.1111/jnc.12325 　

ISSN： 0022-3042

eISSN： 1471-4159
Waveform analysis of ocular blood flow and the early detection of normal tension glaucoma. International-journal Peer-reviewed

Yukihiro Shiga, Kazuko Omodaka, Hiroshi Kunikata, Morin Ryu, Yu Yokoyama, Satoru Tsuda, Toshifumi Asano, Shigeto Maekawa, Kazuichi Maruyama, Toru Nakazawa

Investigative ophthalmology & visual science　54　(12)　7699-706　2013/11/21

DOI： 10.1167/iovs.13-12930 　

ISSN： 0146-0404

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PURPOSE: To investigate waveform changes in blood flow (BF) in the optic nerve head (ONH) and to evaluate their usefulness in identifying normal tension glaucoma (NTG). METHODS: Sixty-one eyes of 61 patients with NTG and 21 eyes of age-matched healthy control subjects were included in this study. The NTG eyes were divided into the following three groups based on the progression of their visual field defects: mild (mean deviation [MD] greater than -6.0 decibels [dB]), moderate (MD between -6.0 and -12.0 dB), and severe (MD less than -12.0 dB). The ONH BF analysis was performed with laser speckle flowgraphy (LSFG) and included waveform variables such as skew, acceleration time index (ATI), and blowout time. RESULTS: In the ONH, LSFG skew variables were significantly lower in the NTG eyes than in the control eyes (P < 0.001), and ATI was significantly higher (P < 0.01), despite similar systemic characteristics in the four groups. The differences were most marked in the mild NTG group. Multiple linear regression analysis showed that MD, average thickness of the circumpapillary retinal nerve fiber layer, and pulse rate were predictive factors for both skew and ATI. A receiver operating characteristic (ROC) curve analysis also revealed that skew (area under the ROC curve, 0.89) and ATI (area under the ROC curve, 0.80) had the greatest power to differentiate normal eyes from eyes with mild NTG. CONCLUSIONS: These results suggest that LSFG measurements of waveform changes in ONH BF can differentiate healthy eyes from eyes with NTG, particularly those with mild NTG.
Simulated Visual Fields Produced from Macular RNFLT Data in Patients with Glaucoma Peer-reviewed

Mai Takahashi, Kazuko Omodaka, Kazuichi Maruyama, Takuhiro Yamaguchi, Noriko Himori, Yukihiro Shiga, Morin Ryu, Hiroshi Kunikata, Toru Nakazawa

CURRENT EYE RESEARCH　38　(11)　1133-1141　2013/11

DOI： 10.3109/02713683.2013.807932 　

ISSN： 0271-3683
Photoreceptor cell death and rescue in retinal detachment and degenerations Peer-reviewed

Yusuke Murakami, Shoji Notomi, Toshio Hisatomi, Toru Nakazawa, Tatsuro Ishibashib, Joan W. Miller, Demetrios G. Vavvas

PROGRESS IN RETINAL AND EYE RESEARCH　37　114-140　2013/11

DOI： 10.1016/j.preteyeres.2013.08.001 　

ISSN： 1350-9462
レーザードップラー流速血流計とレーザースペックルフローグラフィーの相関 Peer-reviewed

浅野俊文, 新田文彦, 國方彦志, 新家眞, 中澤徹

眼科臨床紀要　6　(10)　806-807　2013/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Development of a new strategy of visual field testing for macular dysfunction in patients with open angle glaucoma Peer-reviewed

Kazuko Omodaka, Shiho Kunimatsu-Sanuki, Ryu Morin, Satoru Tsuda, Yu Yokoyama, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

JAPANESE JOURNAL OF OPHTHALMOLOGY　57　(5)　457-462　2013/09

DOI： 10.1007/s10384-013-0258-4 　

ISSN： 0021-5155
Intraocular concentrations of cytokines and chemokines in rhegmatogenous retinal detachment and the effect of intravitreal triamcinolone acetonide. International-journal Peer-reviewed

Hiroshi Kunikata, Masayuki Yasuda, Naoko Aizawa, Yuji Tanaka, Toshiaki Abe, Toru Nakazawa

American journal of ophthalmology　155　(6)　1028-1037　2013/06

DOI： 10.1016/j.ajo.2013.01.013 　

ISSN： 0002-9394

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PURPOSE: To investigate the role of intravitreal injection of triamcinolone acetonide (IVTA) in preventing photoreceptor apoptosis in eyes with rhegmatogenous retinal detachment (RRD) by measuring cytokine levels in the aqueous humor before and after IVTA. DESIGN: Prospective, nonrandomized, interventional case series. METHODS: setting: Institutional. patients: Nineteen eyes of 19 consecutive patients with RRD. intervention: All 19 eyes underwent IVTA 1 day before 25-gauge vitrectomy. Seventeen eyes free of retinal vascular disease served as controls. main outcome measure: Both baseline and 1 day post-IVTA measurements were made of the relative concentrations of 15 soluble factors (3 cytokines, 7 chemokines, and 5 growth factors). The associations with clinical findings, including macular status, were then analyzed. RESULTS: Elevated monocyte chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1β (MIP-1β), and interferon γ-induced protein 10 (IP-10) in eyes with RRD were significantly reduced after IVTA. MCP-1 levels were significantly correlated with MIP-1β and IP-10 before and after IVTA. The decreases in MCP-1, MIP-1β, and IP-10 were also closely correlated to each other. Both before and after IVTA, MCP-1 was higher in eyes with macula-off RRD than in eyes with macula-on RRD. CONCLUSIONS: IVTA suppressed elevated levels of intraocular MCP-1, MIP-1β, and IP-10 in eyes with RRD. The decrease in the aqueous levels of each of these factors was significantly correlated with the others. In addition to MCP-1, MIP-1β and IP-10 might potentially be additional target molecules for RRD therapy.
Effect of Topical Tafluprost on Optic Nerve Head Blood Flow in Patients With Myopic Disc Type Peer-reviewed

Satoru Tsuda, Yu Yokoyama, Naoki Chiba, Naoko Aizawa, Yukihiro Shiga, Masayuki Yasuda, Shunji Yokokura, Takaaki Otomo, Nobuo Fuse, Toru Nakazawa

JOURNAL OF GLAUCOMA　22　(5)　398-403　2013/06

DOI： 10.1097/IJG.0b013e318237c8b3 　

ISSN： 1057-0829
The Influence of Posture Change on Ocular Blood Flow in Normal Subjects, Measured by Laser Speckle Flowgraphy Peer-reviewed

Yukihiro Shiga, Masahiko Shimura, Toshifumi Asano, Satoru Tsuda, Yu Yokoyama, Naoko Aizawa, Kazuko Omodaka, Morin Ryu, Shunji Yokokura, Takayuki Takeshita, Toru Nakazawa

CURRENT EYE RESEARCH　38　(6)　691-698　2013/06

DOI： 10.3109/02713683.2012.758292 　

ISSN： 0271-3683
Visual outcome after intravitreal bevacizumab depends on the optical coherence tomographic patterns of patients with diffuse diabetic macular EDEMA Peer-reviewed

Masahiko Shimura, Kanako Yasuda, Masayuki Yasuda, Toru Nakazawa

Retina　33　(4)　740-747　2013/04

DOI： 10.1097/IAE.0b013e31826b6763 　

ISSN： 0275-004X 1539-2864
Molecular genetic analysis of primary open-angle glaucoma, normal tension glaucoma, and developmental glaucoma for the VAV2 and VAV3 gene variants in Japanese subjects Peer-reviewed

Dong Shi, Yoshimasa Takano, Toru Nakazawa, MinGe Mengkegale, Shunji Yokokura, Kohji Nishida, Nobuo Fuse

Biochemical and Biophysical Research Communications　432　(3)　509-512　2013/03/15

DOI： 10.1016/j.bbrc.2013.02.003 　

ISSN： 0006-291X 1090-2104
Transscleral Sustained Vasohibin-1 Delivery by a Novel Device Suppressed Experimentally-Induced Choroidal Neovascularization Peer-reviewed

Hideyuki Onami, Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Yasufumi Sato, Noriko Osumi, Toru Nakazawa, Toshiaki Abe

PLoS ONE　8　(3)　e58580　2013/03/05

DOI： 10.1371/journal.pone.0058580 　

ISSN： 1932-6203
Combined 25-Gauge Microincision Vitrectomy and Toric Intraocular Lens Implantation With Posterior Capsulotomy Peer-reviewed

Hiroshi Kunikata, Naoko Aizawa, Yasuhiko Meguro, Toshiaki Abe, Toru Nakazawa

OPHTHALMIC SURGERY LASERS & IMAGING　44　(2)　145-154　2013/03

DOI： 10.3928/23258160-20130313-07 　

ISSN： 1542-8877
Comparison of CCD-equipped laser speckle flowgraphy with hydrogen gas clearance method in the measurement of optic nerve head microcirculation in rabbits Peer-reviewed

Hiroaki Takahashi, Tetsuya Sugiyama, Hideki Tokushige, Takatoshi Maeno, Toru Nakazawa, Tsunehiko Ikeda, Makoto Araie

EXPERIMENTAL EYE RESEARCH　108　10-15　2013/03

DOI： 10.1016/j.exer.2012.12.003 　

ISSN： 0014-4835
Combined 25-gauge microincision vitrectomy and toric intraocular lens implantation with posterior capsulotomy Peer-reviewed

Hiroshi Kunikata, Naoko Aizawa, Yasuhiko Meguro, Toshiaki Abe, Toru Nakazawa

Ophthalmic Surgery Lasers and Imaging Retina　44　(2)　145-154　2013/03

DOI： 10.3928/23258160-20130313-07 　

ISSN： 2325-8160 2325-8179

eISSN： 2325-8179
Mechanical characteristic index expressing internal properties of eyeball Peer-reviewed

Yosuke Kimura, Makoto Kaneko, Naoko Aizawa, Yuji Tanaka, Hiroshi Kunikata, Toru Nakazawa

Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C　79　(799)　450-458　2013

DOI： 10.1299/kikaic.79.450 　

ISSN： 0387-5024
The performance of Tohoku University on the innovation of academically driven drug discovery using chemical library Peer-reviewed

Sugawara Akira, Aoki Junken, Dan Takashi, Shimizu Ritsuko, Suzuki Norio, Kano Kuniyuki, Okudaira Shinichi, Hakoda Akiko, Kaneko Hiroshi, Uchida Takafurni, Nakazawa Toru, Doi Takayuki, Miyata Toshio, Oshima Yoshiteru, Yamamoto Masayuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　121　50P-50P　2013

ISSN： 1347-8613
Association of HK2 and NCK2 with Normal Tension Glaucoma in the Japanese Population Peer-reviewed

Dong Shi, Tomoyo Funayama, Yukihiko Mashima, Yoshimasa Takano, Ai Shimizu, Kotaro Yamamoto, MinGe Mengkegale, Akiko Miyazawa, Noriko Yasuda, Takeo Fukuchi, Haruki Abe, Hidenao Ideta, Kohji Nishida, Toru Nakazawa, Julia E. Richards, Nobuo Fuse

PLOS ONE　8　(1)　e54115　2013/01

DOI： 10.1371/journal.pone.0054115 　

ISSN： 1932-6203
The role of the Nrf2-mediated defense system in corneal epithelial wound healing Peer-reviewed

Ryuhei Hayashi, Noriko Himori, Keiko Taguchi, Yuki Ishikawa, Kohji Uesugi, Miyuki Ito, Thomas Duncan, Motokazu Tsujikawa, Toru Nakazawa, Masayuki Yamamoto, Kohji Nishida

Free Radical Biology and Medicine　61　333-342　2013

DOI： 10.1016/j.freeradbiomed.2013.04.008 　

ISSN： 0891-5849 1873-4596
基礎と臨床の融合による失明予防研究

中澤, 徹

東北医学雑誌　124　(2)　203-204　2012/12
Publisher: 東北医学会
ISSN： 0040-8700

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紀要類（bulletin）
Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor Peer-reviewed

Ahmed Y. Shanab, Toru Nakazawa, Morin Ryu, Yuji Tanaka, Noriko Himori, Keiko Taguchi, Masayuki Yasuda, Ryo Watanabe, Jiro Takano, Takaomi Saido, Naoko Minegishi, Toshio Miyata, Toshiaki Abe, Masayuki Yamamoto

NEUROBIOLOGY OF DISEASE　48　(3)　556-567　2012/12

DOI： 10.1016/j.nbd.2012.07.025 　

ISSN： 0969-9961

eISSN： 1095-953X
Association of Toll-like Receptor 4 Gene Polymorphisms in Japanese Subjects With Primary Open-Angle, Normal-Tension, and Exfoliation Glaucoma Peer-reviewed

Yoshimasa Takano, Dong Shi, Ai Shimizu, Tomoyo Funayama, Yukihiko Mashima, Noriko Yasuda, Takeo Fukuchi, Haruki Abe, Hidenao Ideta, Xiaodong Zheng, Atsushi Shiraishi, Yuichi Ohashi, Kohji Nishida, Toru Nakazawa, Nobuo Fuse

AMERICAN JOURNAL OF OPHTHALMOLOGY　154　(5)　825-832　2012/11

DOI： 10.1016/j.ajo.2012.03.050 　

ISSN： 0002-9394
A case of choroidal neovascularization after macular hole surgery

Azusa Ito, Hiroshi Kunikata, Toshiaki Abe, Masayiiki Yasuda, Toru Nakazawa

Folia Japonica de Ophthalmologica Clinica　5　(9)　855-859　2012/09

ISSN： 1882-5176
Efficacy of combined 25-gauge microincision vitrectomy, intraocular lens implantation, and posterior capsulotomy Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Toshiaki Abe, Toru Nakazawa

JOURNAL OF CATARACT AND REFRACTIVE SURGERY　38　(9)　1602-1607　2012/09

DOI： 10.1016/j.jcrs.2012.05.028 　

ISSN： 0886-3350
Choroidal excavation with polypoidal choroidal vasculopathy: A case report Peer-reviewed

Wataru Kobayashi, Toshiaki Abe, Hiroshi Tamai, Toru Nakazawa

Clinical Ophthalmology　6　(1)　1373-1376　2012/08/24

DOI： 10.2147/OPTH.S33879 　

ISSN： 1177-5467 1177-5483
Outcome of microincision vitrectomy for idiopathic macular hole with or without triamcinolone acetonide

Hiroko Kanazawa, Hiroshi Kunikata, Masayuki Yasuda, Fumihiko Nitta, Jiro Kinukawa, Toshiaki Abe, Toru Nakazawa

Japanese Journal of Clinical Ophthalmology　66　(8)　1219-1224　2012/08

ISSN： 0370-5579
Intraoperative choroidal detachment during 25-gauge vitrectomy

Naoko Aizawa, Hiroshi Kunikata, Chiyoko Okamura, Toshiaki Abe, Toru Nakazawa

Folia Japonica de Ophthalmologica Clinica　5　(8)　792-796　2012/08

ISSN： 1882-5176
Progression of Visual Field Defects in Eyes With Different Optic Disc Appearances in Patients With Normal Tension Glaucoma Peer-reviewed

Toru Nakazawa, Masahiko Shimura, Morin Ryu, Noriko Himori, Fumihiko Nitta, Kazuko Omodaka, Hiroshi Doi, Tomoki Yasui, Nobuo Fuse, Kohji Nishida

JOURNAL OF GLAUCOMA　21　(6)　426-430　2012/08

DOI： 10.1097/IJG.0b013e3182182897 　

ISSN： 1057-0829
The Regulatory Roles of Apoptosis-Inducing Factor in the Formation and Regression Processes of Ocular Neovascularization Peer-reviewed

Toshio Hisatomi, Shintaro Nakao, Yusuke Murakami, Kousuke Noda, Toru Nakazawa, Shoji Notomi, Edward Connolly, Haicheng She, Lama Almulki, Yasuhiro Ito, Demetrios G. Vavvas, Tatsuro Ishibashi, Joan W. Miller

AMERICAN JOURNAL OF PATHOLOGY　181　(1)　53-61　2012/07

DOI： 10.1016/j.ajpath.2012.03.022 　

ISSN： 0002-9440
[Analysis of retinal nerve fiber layer thickness in superior segmental optic hypoplasia (SSOH)]. Peer-reviewed

Fuse N, Aizawa N, Yokoyama Y, Nakamura M, Omodaka K, Sado K, Nakazawa T

Nippon Ganka Gakkai zasshi　116　(6)　575-580　2012/06
Publisher:
ISSN： 0029-0203
The Maintenance of Lymphatic Vessels in the Cornea Is Dependent on the Presence of Macrophages Peer-reviewed

Kazuichi Maruyama, Toru Nakazawa, Claus Cursiefen, Yuko Maruyama, Nico Van Rooijen, Patricia A. D'Amore, Shigeru Kinoshita

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　53　(6)　3145-3153　2012/05

DOI： 10.1167/iovs.11-8010 　

ISSN： 0146-0404
Evaluation of CNTNAP2 gene polymorphisms for exfoliation syndrome in Japanese Peer-reviewed

Ai Shimizu, Yoshimasa Takano, Dong Shi, Shunji Yokokura, Yu Yokoyama, Xiaodong Zheng, Atsushi Shiraishi, Yuichi Ohashi, Toru Nakazawa, Nobuo Fuse

MOLECULAR VISION　18　(142-45)　1395-1401　2012/05

ISSN： 1090-0535
Critical Role of Calpain in Axonal Damage-Induced Retinal Ganglion Cell Death Peer-reviewed

Morin Ryu, Masayuki Yasuda, Dong Shi, Ahmed Y. Shanab, Ryo Watanabe, Noriko Himori, Kazuko Omodaka, Yu Yokoyama, Jiro Takano, Takaomi Saido, Toru Nakazawa

JOURNAL OF NEUROSCIENCE RESEARCH　90　(4)　802-815　2012/04

DOI： 10.1002/jnr.22800 　

ISSN： 0360-4012
Comparison of Corneal and Aqueous Humor Penetration of Moxifloxacin, Gatifloxacin and Levofloxacin during Keratoplasty Peer-reviewed

Masahiko Fukuda, Masakazu Yamada, Shigeru Kinoshita, Tsutomu Inatomi, Yuichi Ohashi, Toshihiko Uno, Jun Shimazaki, Yoshiyuki Satake, Naoyuki Maeda, Yuichi Hori, Kohji Nishida, Akira Kubota, Toru Nakazawa, Yoshikazu Shimomura

ADVANCES IN THERAPY　29　(4)　339-349　2012/04

DOI： 10.1007/s12325-012-0016-x 　

ISSN： 0741-238X
Chemokines in aqueous humour before and after intravitreal triamcinolone acetonide in eyes with macular oedema associated with branch retinal vein occlusion Peer-reviewed

Hiroshi Kunikata, Masahiko Shimura, Toru Nakazawa, Koh-Hei Sonoda, Takeru Yoshimura, Tatsuro Ishibashi, Kohji Nishida

ACTA OPHTHALMOLOGICA　90　(2)　162-167　2012/03

DOI： 10.1111/j.1755-3768.2010.01892.x 　

ISSN： 1755-375X

eISSN： 1755-3768
分子徐放デバイスと神経保護

大浪英之, 永井展裕, 梶弘和, 西澤松彦, 佐藤靖史, 中澤徹, 阿部俊明

Proceedings of Clinical Electron Microscopy　31　31-34　2012/01
Publisher: 東北臨床超微形態懇話会世話人会
The Clinical Characteristics of Two Anti-OJ (Anti-Isoleucylt-RNA Synthetase) Autoantibody-Positive Interstitial Lung Disease Patients with Polymyositis/Dermatomyositis Peer-reviewed

Kei Kunimasa, Machiko Arita, Takashi Nakazawa, Maki Tanaka, Kazuya Tsubouchi, Satoshi Konishi, Yasushi Fukuda, Mika Saigusa, Hiroaki Nakagawa, Satoshi Ubukata, Yohei Korogi, Takao Fujii, Tsuneyo Mimori, Tadashi Ishida

INTERNAL MEDICINE　51　(24)　3405-3410　2012

DOI： 10.2169/internalmedicine.51.7452 　

ISSN： 0918-2918
Evaluation of the Effects of Acupuncture on Blood Flow in Humans with Ultrasound Color Doppler Imaging Peer-reviewed

Shin Takayama, Masashi Watanabe, Hiroko Kusuyama, Satoru Nagase, Takashi Seki, Toru Nakazawa, Nobuo Yaegashi

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE　2012　513638　2012

DOI： 10.1155/2012/513638 　

ISSN： 1741-427X

eISSN： 1741-4288
Over 10 years follow-up of Coats' disease in adulthood Peer-reviewed

Tatsuro Otani, Kanako Yasuda, Naoko Aizawa, Fumiaki Sakai, Toru Nakazawa, Masahiko Shimura

Clinical Ophthalmology　5　(1)　1729-1732　2011/12/07

DOI： 10.2147/OPTH.S27938 　

ISSN： 1177-5467 1177-5483
Significant correlations between optic nerve head microcirculation and visual field defects and nerve fiber layer loss in glaucoma patients with myopic glaucomatous disk Peer-reviewed

Yu Yokoyama, Naoko Aizawa, Naoki Chiba, Kazuko Omodaka, Masahiko Nakamura, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa

Clinical Ophthalmology　5　(1)　1721-1727　2011/12/06

DOI： 10.2147/OPTH.S23204 　

ISSN： 1177-5467 1177-5483
Miami to Japan Eye-Care Rescue Mission: Vision Van Helps with Relief Efforts Peer-reviewed

Kazuo Tsubota, Tsunehiko Yoshida, Daijiro Kurosaka, Richard K. Lee, Eduardo C. Alfonso, Toru Nakazawa

AMERICAN JOURNAL OF OPHTHALMOLOGY　152　(5)　886-887　2011/11

DOI： 10.1016/j.ajo.2011.07.029 　

ISSN： 0002-9394
【臨床シリーズ加齢性眼科疾患】緑内障に対する鍼治療の効果と機序の検討

関隆志, 渡部, 正司, 松田, 綾音, 神谷, 哲治, 中澤, 徹, 布施, 昇男, 來須, 正幸, 高山真

鍼灸Osaka　27　(2)　647-651　2011/08
Publisher:
ISSN： 1340-6280
Choroidal blood flow following photodynamic therapy measured by laser speckle flowgraphy

Fumihiko Nitta, Hiroshi Kunikata, Toru Nakazawa, Jiro Kinugawa, Masayuki Yasuda, Toshiaki Abe

Japanese Journal of Clinical Ophthalmology　65　(6)　863-868　2011/06/15

ISSN： 0370-5579
Success Rates of Trabeculotomy for Steroid-Induced Glaucoma: A Comparative, Multicenter, Retrospective Cohort Study Peer-reviewed

Keiichiro Iwao, Masaru Inatani, Hidenobu Tanihara

AMERICAN JOURNAL OF OPHTHALMOLOGY　151　(6)　1047-1056　2011/06

DOI： 10.1016/j.ajo.2010.11.028 　

ISSN： 0002-9394
Suppression of phagocytic cells in retinal disorders using amphiphilic poly (gamma-glutamic acid) nanoparticles containing dexamethasone Peer-reviewed

Morin Ryu, Toru Nakazawa, Takami Akagi, Tatsuhide Tanaka, Ryou Watanabe, Masayuki Yasuda, Noriko Himori, Kazuichi Maruyama, Toshihide Yamashita, Toshiaki Abe, Mitsuru Akashi, Kohji Nishida

JOURNAL OF CONTROLLED RELEASE　151　(1)　65-73　2011/04

DOI： 10.1016/j.jconrel.2010.11.029 　

ISSN： 0168-3659
Pre-seasonal Treatment With Topical Olopatadine Suppresses the Clinical Symptoms of Seasonal Allergic Conjunctivitis Peer-reviewed

Masahiko Shimura, Kanako Yasuda, Akiko Miyazawa, Tetsuro Otani, Toru Nakazawa

AMERICAN JOURNAL OF OPHTHALMOLOGY　151　(4)　697-702　2011/04

DOI： 10.1016/j.ajo.2010.10.001 　

ISSN： 0002-9394
VISUAL OUTCOME AFTER INTRAVITREAL TRIAMCINOLONE ACETONIDE DEPENDS ON OPTICAL COHERENCE TOMOGRAPHIC PATTERNS IN PATIENTS WITH DIFFUSE DIABETIC MACULAR EDEMA Peer-reviewed

Masahiko Shimura, Kanako Yasuda, Toru Nakazawa, Yoshio Hirano, Taiji Sakamoto, Yuichiro Ogura, Takashi Shiono

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES　31　(4)　748-754　2011/04

DOI： 10.1097/IAE.0b013e3181f04991 　

ISSN： 0275-004X

eISSN： 1539-2864
Polymorphisms in ARMS2 (LOC387715) and LOXL1 Genes in the Japanese With Age-Related Macular Degeneration Peer-reviewed

Nobuo Fuse, Mingge Mengkegale, Akiko Miyazawa, Toshiaki Abe, Toru Nakazawa, Ryosuke Wakusawa, Kohji Nishida

AMERICAN JOURNAL OF OPHTHALMOLOGY　151　(3)　550-556　2011/03

DOI： 10.1016/j.ajo.2010.08.048 　

ISSN： 0002-9394
Heat Shock Protein 70 (HSP70) Is Critical for the Photoreceptor Stress Response after Retinal Detachment via Modulating Anti-Apoptotic Akt Kinase Peer-reviewed

Maki Kayama, Toru Nakazawa, Aristomenis Thanos, Yuki Morizane, Yusuke Murakami, Sofia Theodoropoulou, Toshiaki Abe, Demetrios Vavvas, Joan W. Miller

AMERICAN JOURNAL OF PATHOLOGY　178　(3)　1080-1091　2011/03

DOI： 10.1016/j.ajpath.2010.11.072 　

ISSN： 0002-9440
Tumor Necrosis Factor-alpha Mediates Photoreceptor Death in a Rodent Model of Retinal Detachment Peer-reviewed

Toru Nakazawa, Maki Kayama, Morin Ryu, Hiroshi Kunikata, Ryou Watanabe, Masayuki Yasuda, Jiro Kinugawa, Demetrios Vavvas, Joan W. Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　52　(3)　1384-1391　2011/03

DOI： 10.1167/iovs.10-6509 　

ISSN： 0146-0404
Short-Term Effects of Acupuncture on Open-Angle Glaucoma in Retrobulbar Circulation: Additional Therapy to Standard Medication Peer-reviewed

Shin Takayama, Takashi Seki, Toru Nakazawa, Naoko Aizawa, Seri Takahashi, Masashi Watanabe, Masayuki Izumi, Soichiro Kaneko, Tetsuharu Kamiya, Ayane Matsuda, Akiko Kikuchi, Tomoyuki Yambe, Makoto Yoshizawa, Shin-ichi Nitta, Nobuo Yaegashi

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE　2011　1-6　2011

DOI： 10.1155/2011/157090 　

ISSN： 1741-427X

eISSN： 1741-4288
Successful Removal of Large Intraocular Foreign Body by 25-Gauge Microincision Vitrectomy Surgery Peer-reviewed

Hiroshi Kunikata, Megumi Uematsu, Toru Nakazawa, Nobuo Fuse

JOURNAL OF OPHTHALMOLOGY　2011　940323　2011

DOI： 10.1155/2011/940323 　

ISSN： 2090-004X
Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma. International-journal Peer-reviewed

Aizawa N, Yokoyama Y, Chiba N, Omodaka K, Yasuda M, Otomo T, Nakamura M, Fuse N, Nakazawa T

Clinical ophthalmology (Auckland, N.Z.)　5　1171-1176　2011

DOI： 10.2147/OPTH.S22093 　

ISSN： 1177-5467

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BACKGROUND: Laser speckle flowgraphy (LSFG) enables noninvasive quantification of the retinal circulation in glaucoma patients. In this study, we tested the intrasession reproducibility of LSFG-NAVI, a modified LSFG technique. METHODS: Sixty-five eyes from 33 subjects (male (M):female (F) = 17:16) with a mean age of 49.4 ± 11.2 years were examined in this study. Two parameters indicating reproducibility - the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) - were analyzed three times on the same day that mean blur rate (MBR) was measured using LSFG-NAVI. The sites analyzed were the retinal artery and vein, the optic disk, and the choroid. Following classification according to the Glaucoma Hemifield Test (GHT; SITA-Standard 30-2 program), the COV and ICC were examined in patients with (GHT+; 38 eyes, M:F = 20:18, average age 48.9 ± 12.8 years) and without (GHT-; 27 eyes, M:F = 13:14, average age 50.1 ± 8.7 years) abnormal glaucomatous visual fields. RESULTS: FOR ALL SUBJECTS, THE INTRASESSION REPRODUCIBILITY OF MBR IN THE OPTIC DISK (COV: 3.4 ± 2.0; ICC: 0.95) and choroid (COV: 4.7 ± 3.4; ICC: 0.98) was excellent. The reproducibility for the retinal vein (COV: 8.4 ± 5.6, ICC: 0.90) and retinal artery (COV: 10.9 ± 9.9, ICC: 0.9) was moderate. MBRs in the optic disk had good reproducibility in both the GHT+ group (COV: 3.8 ± 2.0; ICC: 0.97) and the GHT- group (COV: 2.9 ± 2.1; ICC: 0.95). Local assessment of the optic disk in normal or glaucoma patients showed that the COVs of the quadrant optic disk areas were best in the temporal area of MBR (3.4%, 4.2%, respectively). CONCLUSION: LSFG-NAVI showed favorable reproducibility in evaluation of retinal circulation of glaucoma patients, particularly in the optic disk and choroid.
Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type. International-journal Peer-reviewed

Chiba N, Omodaka K, Yokoyama Y, Aizawa N, Tsuda S, Yasuda M, Otomo T, Yokokura S, Fuse N, Nakazawa T

Clinical ophthalmology (Auckland, N.Z.)　5　1549-1556　2011

DOI： 10.2147/OPTH.S22097 　

ISSN： 1177-5467

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BACKGROUND: The purpose of this study was to investigate the correlations between microcirculation in the optic disc, average peripapillary retinal nerve fiber layer thickness cupping parameters, and visual field defects in glaucoma patients with the generalized enlargement disc type. METHODS: A total of 38 eyes from 38 glaucoma patients with the generalized enlargement disc type were included. The microcirculation of the optic nerve head was examined with laser speckle flow graphy, and the mean blur rate in all areas, in vessel area, and in tissue area were calculated using the laser speckle flow graphy analyzer software. Average peripapillary retinal nerve fiber layer thickness was measured using Stratus optical coherence tomography, and cupping parameters were accessed using the Heidelberg retina tomograph. The mean deviation in the Humphrey field analyzer (30-2 SITA standard) was analyzed. The correlation between these parameters was evaluated using the Spearman rank correlation coefficient. RESULTS: The correlation coefficient of mean blur rate in all optic disc area to the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation were r = 0.7546 (P < 0.0001), r = -0.6208 (P < 0.0001), and r = 0.6010 (P = 0.0001), respectively. The mean blur rate in tissue area of the optic disc showed r = 0.7305 (P < 0.0001), r = -0.6438 (P < 0.0001), and r = 0.6338 (P < 0.0001). CONCLUSION: We found that the mean blur rate in the optic disc was significantly correlated with the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation in patients with the generalized enlargement disc type of glaucoma. In particular, the mean blur rate in tissue area was more highly correlated than the vessel area with other results of examination in glaucoma patients with the generalized enlargement disc type.
Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica Peer-reviewed

Masahiko Nakamura, Toru Nakazawa, Hiroshi Doi, Takehiro Hariya, Kazuko Omodaka, Tatsuro Misu, Toshiyuki Takahashi, Kazuo Fujihara, Kohji Nishida

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　248　(12)　1777-1785　2010/12

DOI： 10.1007/s00417-010-1344-7 　

ISSN： 0721-832X
Combination Therapy for Retinal Vein Occlusion Peer-reviewed

Masahiko Shimura, Kanako Yasuda, Toru Nakazawa, Takayuki Takeshita, Takashi Shiono, Taijii Sakamoto

OPHTHALMOLOGY　117　(9)　1858-U220　2010/09

DOI： 10.1016/j.ophtha.2010.03.077 　

ISSN： 0161-6420
Correlation between peripapillary macular fiber layer thickness and visual acuity in patients with open-angle glaucoma. International-journal Peer-reviewed

Omodaka K, Nakazawa T, Yokoyama Y, Doi H, Fuse N, Nishida K

Clinical ophthalmology (Auckland, N.Z.)　4　629-635　2010/07

ISSN： 1177-5467

eISSN： 1177-5483

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PURPOSE: To determine whether the best-corrected visual acuity (BCVA) is significantly correlated with the retinal nerve fiber layer thickness (RNFLT) in the different peripapillary areas in eyes with open-angle glaucoma (OAG). PATIENTS AND METHODS: Two hundred twenty-nine eyes of 159 patients with OAG were studied. The overall RNFLT and the RNFLT in the superior (S), temporal (T), inferior (I), and nasal (N) quadrants were measured by Stratus optical coherence tomography (OCT). In addition, the temporal RNFLT was measured for three 30 degrees sectors with the mid-temporal (mT) sector at the three or nine o'clock position. The Spearman coefficient of correlation was calculated to determine whether a significant correlation existed between the RNFLT and the BCVA. Eyes with a BCVA <20/20 were classified as having decreased BCVA. RESULTS: There were significant correlations between the BCVA and the overall RNFLT, and also between the BCVA and the RNFLT in the T, I, and S quadrants. The coefficient correlation between the BCVA and RNFLT was the highest in the mT sector (r = -0.40, P < 0.0001). Forty-eight eyes (21.1%) were classified as having decreased BCVA. The cut-off value of the mT sector for eyes with decreased VA was 39.0 mum. CONCLUSION: The highest correlation between the BCVA and the RNFLT in the mT sector was most likely due to the location of the maculopapillary bundle in this region of the optic disc. Our findings indicate that when the RNFLT in the mT sector is reduced to 40 mum, glaucoma treatment should be reconsidered.
Correlation between morphology of optic disc determined by Heidelberg Retina Tomograph II and visual function in eyes with open-angle glaucoma. Peer-reviewed

Omodaka K, Nakazawa T, Otomo T, Nakamura M, Fuse N, Nishida K

Clinical ophthalmology (Auckland, N.Z.)　4　765-772　2010/07

ISSN： 1177-5467
Different types of optic disc shape in patients with advanced open-angle glaucoma Peer-reviewed

Toru Nakazawa, Nobuo Fuse, Kazuko Omodaka, Naoko Aizawa, Souichiro Kuwahara, Kohji Nishida

JAPANESE JOURNAL OF OPHTHALMOLOGY　54　(4)　291-295　2010/07

DOI： 10.1007/s10384-010-0816-y 　

ISSN： 0021-5155
Susceptibility to N-methyl-d-aspartate toxicity in morphological and functional types of cat retinal ganglion cells Peer-reviewed

Toru Nakazawa, Masami Watanabe, Hideyo Kudo, Kohji Nishida, Makoto Tamai

JAPANESE JOURNAL OF OPHTHALMOLOGY　54　(2)　156-162　2010/03

DOI： 10.1007/s10384-009-0785-1 　

ISSN： 0021-5155
Mutation spectrum of the CYP1B1 gene for congenital glaucoma in the Japanese population Peer-reviewed

Nobuo Fuse, Akiko Miyazawa, Kana Takahashi, Michiru Noro, Toru Nakazawa, Kohji Nishida

JAPANESE JOURNAL OF OPHTHALMOLOGY　54　(1)　1-6　2010/01

DOI： 10.1007/s10384-009-0769-1 　

ISSN： 0021-5155
A case of unilateral optic disc swelling with chronic active Epstein-Barr virus infection Peer-reviewed

Naoko Aizawa, Toru Nakazawa, Masahiko Shimura

Clinical Ophthalmology　4　(1)　977-979　2010

DOI： 10.2147/OPTH.S13048 　

ISSN： 1177-5467 1177-5483
Fluoroquinolone antibacterial eye drops: Effects on normal human corneal epithelium, stroma, and endothelium Peer-reviewed

Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, Akira Kubota, Hisayo Kubota, Kohji Nishida

Clinical Ophthalmology　4　(1)　1181-1187　2010

DOI： 10.2147/OPTH.S13672 　

ISSN： 1177-5467 1177-5483
Observation of posterior corneal vesicles with in vivo confocal microscopy and anterior segment OCT Peer-reviewed

Ryou Watanabe, Toru Nakazawa, Nobuo Fuse

Clinical Ophthalmology　4　(1)　1243-1247　2010

DOI： 10.2147/OPTH.S14550 　

ISSN： 1177-5467 1177-5483
Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy Peer-reviewed

Masahiko Shimura, Kanako Yasuda, Toru Nakazawa, Toshiaki Abe, Takashi Shiono, Tomohiro Iida, Taiji Sakamoto, Kohji Nishida

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　247　(12)　1617-1624　2009/12

DOI： 10.1007/s00417-009-1147-x 　

ISSN： 0721-832X
[Mechanism of N-methyl-D-aspartate-induced retinal ganglion cell death]. Peer-reviewed

Nakazawa T

Nippon Ganka Gakkai zasshi　113　(11)　1060-1070　2009/11
Publisher:
ISSN： 0029-0203
Activated Retinal Glia Promote Neurite Outgrowth of Retinal Ganglion Cells Via Apolipoprotein E Peer-reviewed

Barbara Lorber, Martin Berry, Michael R. Douglas, Toru Nakazawa, Ann Logan

JOURNAL OF NEUROSCIENCE RESEARCH　87　(12)　2645-2652　2009/09

DOI： 10.1002/jnr.22095 　

ISSN： 0360-4012
Drug reflux during posterior subtenon infusion of triamcinolone acetonide in diffuse diabetic macular edema not only brings insufficient reduction but also causes elevation of intraocular pressure Peer-reviewed

Masahiko Shimura, Kanako Yasuda, Toru Nakazawa, Takashi Shiono, Taiji Sakamoto, Kohji Nishida

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　247　(7)　907-912　2009/07

DOI： 10.1007/s00417-009-1074-x 　

ISSN： 0721-832X
Calpain-Mediated Degradation of G-Substrate Plays a Critical Role in Retinal Excitotoxicity for Amacrine Cells Peer-reviewed

Toru Nakazawa, Masahiko Shimura, Ryu Mourin, Mineo Kondo, Shunji Yokokura, Takaomi C. Saido, Kohji Nishida, Shogo Endo

JOURNAL OF NEUROSCIENCE RESEARCH　87　(6)　1412-1423　2009/05

DOI： 10.1002/jnr.21953 　

ISSN： 0360-4012

eISSN： 1097-4547
Surprising up-regulation of P-selectin glycoprotein ligand-1 (PSGL-1) in endotoxin-induced uveitis Peer-reviewed

Lama Almulki, Kousuke Noda, Reza Amini, Alexander Schering, Rebecca C. Garland, Shintaro Nakao, Toru Nakazawa, Toshio Hisatomi, Kennard L. Thomas, Sharmila Masli, Ali Hafezi-Moghadam

FASEB JOURNAL　23　(3)　929-939　2009/03

DOI： 10.1096/fj.08-118760 　

ISSN： 0892-6638
Susceptibility comparisons of normal preoperative conjunctival bacteria to fluoroquinolones Peer-reviewed

Yuichi Hori, Toru Nakazawa, Naoyuki Maeda, Masako Sakamoto, Syunji Yokokura, Akira Kubota, Tomoyuki Inoue, Kohji Nishida, Yasu Tano

JOURNAL OF CATARACT AND REFRACTIVE SURGERY　35　(3)　475-479　2009/03

DOI： 10.1016/j.jcrs.2008.11.049 　

ISSN： 0886-3350
Diclofenac prevents temporal increase of intraocular pressure after uneventful cataract surgery with longer operation time. Peer-reviewed

Shimura M, Nakazawa T, Yasuda K, Shiono T, Nishida K

Clinical ophthalmology (Auckland, N.Z.)　3　95-101　2009

ISSN： 1177-5467
Pyroglutamic Acid Promotes Survival of Retinal Ganglion Cells after Optic Nerve Injury Peer-reviewed

Shinichirou Oono, Takuji Kurimoto, Tomomitsu Miyoshi, Yoshimasa Ito, Toru Nakazawa, Norio Okamoto, Ryosuke Kashimoto, Yuichi Tagami, Osamu Mimura

CURRENT EYE RESEARCH　34　(7)　598-605　2009

DOI： 10.1080/02713680902981292 　

ISSN： 0271-3683
Photoreceptor Protection after Photodynamic Therapy Using Dexamethasone in a Rat Model of Choroidal Neovascularization Peer-reviewed

Haicheng She, Toru Nakazawa, Akihisa Matsubara, Edward Connolly, Toshio Hisatomi, Kousuke Noda, Ivana Kim, Evangelos S. Gragoudas, Joan W. Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　49　(11)　5008-5014　2008/11

DOI： 10.1167/iovs.07-1154 　

ISSN： 0146-0404
Vascular adhesion protein-1 blockade suppresses choroidal neovascularization Peer-reviewed

Kousuke Noda, Haicheng She, Toru Nakazawa, Toshio Hisatomi, Shintaro Nakao, Lama Almulki, Souska Zandi, Shinsuke Miyahara, Yasuhiro Ito, Kennard L. Thomas, Rebecca C. Garland, Joan W. Miller, Evangelos S. Gragoudas, Yukihiko Mashima, Ali Hafezi-Moghadam

FASEB JOURNAL　22　(8)　2928-2935　2008/08

DOI： 10.1096/fj.07-105346 　

ISSN： 0892-6638
Evaluation of LOXL1 polymorphism in eyes with exfoliation glaucoma in Japanese Peer-reviewed

Nobuo Fuse, Akiko Miyazawa, Toru Nakazawa, MingGe Mengkegale, Takaaki Otomo, Kohji Nishida

MOLECULAR VISION　14　(161-62)　1338-1343　2008/07

ISSN： 1090-0535
Visual prognosis and vitreous cytokine levels after arteriovenous sheathotomy in branch retinal vein occlusion associated with macular oedema Peer-reviewed

Masahiko Shimura, Toru Nakazawa, Kanako Yasuda, Hiroshi Kunikata, Takashi Shiono, Kohji Nishida

ACTA OPHTHALMOLOGICA　86　(4)　377-384　2008/06

DOI： 10.1111/j.1600-0420.2007.01074.x 　

ISSN： 1755-375X
In vivo imaging of endothelial injury in choriocapillaris during endotoxin-induced uveitis Peer-reviewed

Shinsuke Miyahara, Lama Almulki, Kousuke Noda, Toru Nakazawa, Toshio Hisatomi, Shintaro Nakao, Kennard L. Thomas, Alexander Schering, Souska Zandi, Sonja Frimmel, Faryan Tayyari, Rebecca C. Garland, Joan W. Miller, Evangelos S. Gragoudas, Sharmila Masli, Ali Hafezi-Moghadam

FASEB JOURNAL　22　(6)　1973-1980　2008/06

DOI： 10.1096/fj.07-096891 　

ISSN： 0892-6638
HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice Peer-reviewed

Toshio Hisatomi, Toru Nakazawa, Kousuke Noda, Lama Almulki, Shinsuke Miyahara, Shintaro Nakao, Yasuhiro Ito, Haicheng She, Riichiro Kohno, Norman Michaud, Tatsuro Ishibashi, Ali Hafezi-Moghadam, Andrew D. Badley, Guido Kroemer, Joan W. Miller

JOURNAL OF CLINICAL INVESTIGATION　118　(6)　2025-2038　2008/06

DOI： 10.1172/JCI34267 　

ISSN： 0021-9738
Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema Peer-reviewed

Masahiko Shimura, Toru Nakazawa, Kanako Yasuda, Takashi Shiono, Tomohiro Iida, Taiji Sakamoto, Koh Nishida

AMERICAN JOURNAL OF OPHTHALMOLOGY　145　(5)　854-861　2008/05

DOI： 10.1016/j.ajo.2007.12.031 　

ISSN： 0002-9394

eISSN： 1879-1891
Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveifs Peer-reviewed

Kousuke Noda, Shinsuke Miyahara, Torn Nakazawa, Lama Almulki, Shintaro Nakao, Toshio Hisatomi, Haicheng She, Kennard L. Thomas, Rebecca C. Garland, Joan W. Miller, Evangelos S. Gragoudas, Yosuke Kawai, Yukihiko Mashima, Ali Hafezi-Moghadam

FASEB JOURNAL　22　(4)　1094-1103　2008/04

DOI： 10.1096/fj.07-9377com 　

ISSN： 0892-6638
Presence of myocilin sequence variants in Japanese patients with open-angle glaucoma Peer-reviewed

MingGe Mengkegale, Nobuo Fuse, Akiko Miyazawa, Kana Takahashi, Motohiko Seimiya, Tomoki Yasui, Makoto Tamai, Toru Nakazawa, Kohji Nishida

MOLECULAR VISION　14　(46-53)　413-417　2008/03

ISSN： 1090-0535
Characterization of azurocidin as a permeability factor in the retina: Involvement in VEGF-induced and early diabetic blood-retinal barrier breakdown Peer-reviewed

Dimitra Skondra, Kousuke Noda, Lama Almulki, Faryan Tayyari, Sonja Frimmel, Toru Nakazawa, Ivana K. Kim, Souska Zandi, Kennard L. Thomas, Joan W. Miller, Evangelos S. Gragoudas, Ali Hafezi-Moghadam

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　49　(2)　726-731　2008/02

DOI： 10.1167/iovs.07-0405 　

ISSN： 0146-0404
Correlation between visual field defect and retinal nerve fiber layer thickness in glaucoma

Takaaki Otomo, Nobuo Fuse, Motohiko Seimiya, Toru Nakazawa, Kohji Nishida

Japanese Journal of Clinical Ophthalmology　62　(5)　723-726　2008

ISSN： 0370-5579
ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury Peer-reviewed

Toru Nakazawa, Masahiko Shimura, Morin Ryu, Kohji Nishida, Gilles Pages, Jacques Pouyssegur, Shogo Endo

JOURNAL OF NEUROSCIENCE RESEARCH　86　(1)　136-144　2008/01

DOI： 10.1002/jnr.21472 　

ISSN： 0360-4012

eISSN： 1097-4547
巨大角結膜乳頭腫の１例 Peer-reviewed

横倉俊二, 助川真里絵, 中澤徹, 久保田享, 劉孟林, 目黒泰彦, 横山悠, 西田幸二

日本眼科紀要　58　(12)　719-722　2007/12

ISSN： 0015-5667
Photodynamic therapy induces caspase-dependent apoptosis in rat CNV model Peer-reviewed

Akihisa Matsubara, Toru Nakazawa, Kosuke Noda, Haicheng She, Edward Connolly, Tara A. Young, Yuichiro Ogura, Evangelos S. Gragoudas, Joan W. Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　48　(10)　4741-4747　2007/10

DOI： 10.1167/iovs.06-1534 　

ISSN： 0146-0404
Dexamethasone inhibits interleukin-1 beta-induced corneal neovascularization - Role of nuclear factor-kappa B-activated stromal cells in inflammatory angiogenesis Peer-reviewed

Shintaro Nakao, Yasuaki Hata, Muneki Miura, Kousuke Noda, Yusuke N. Kimura, Shulhei Kawahara, Takeshi Kita, Toshio Hisatomi, Tonu Nakazawa, Yiping Jin, M. Reza Dana, Michihiko Kuwano, Mayumi Ono, Tatsuro Ishibashi, Ali Hafezi-Moghadam

AMERICAN JOURNAL OF PATHOLOGY　171　(3)　1058-1065　2007/09

DOI： 10.2353/ajpath.2007.070172 　

ISSN： 0002-9440
コントラスト感度視力検査装置による緑内障患者に対する鍼治療の視機能評価 Peer-reviewed

相良淑子, 布施昇男, 関隆志, 中澤徹, 高橋佳奈, 清宮基彦, 横倉俊二, 来須正幸, 西田幸二

眼科臨床医報　101　(6)　715-718　2007/06
Publisher:
ISSN： 0386-9601
Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin Peer-reviewed

Toru Nakazawa, Masumi Takeda, Geoffrey P. Lewis, Kin-Sang Cho, Jianwei Jiao, Ulrika Wilhelmsson, Steven K. Fisher, Milos Pekny, Dong F. Chen, Joan W. Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　48　(6)　2760-2768　2007/06

DOI： 10.1167/iovs.06-1398 　

ISSN： 0146-0404
Diclofenac prevents an early event of macular thickening after cataract surgery in patients with diabetes Peer-reviewed

Masahiko Shimura, Toru Nakazawa, Kanako Yasuda, Kohji Nishida

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS　23　(3)　284-291　2007/06

DOI： 10.1089/jop.2006.134 　

ISSN： 1080-7683
Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization Peer-reviewed

Haicheng She, Toru Nakazawa, Akihisa Matsubara, Toshio Hisatomi, Tara A. Young, Norman Michaud, Edward Connolly, Ali Hafezi-Moghadam, Evangelos S. Gragoudas, Joan W. Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　48　(5)　2268-2277　2007/05

DOI： 10.1167/iovs.06-0979 　

ISSN： 0146-0404
Identification of resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation Peer-reviewed

Toshio Hisatomi, Koh-hei Sonoda, Fumihiko Ishikawa, Hong Qiao, Takahiro Nakamura, Mitsuhiro Fukata, Toru Nakazawa, Kousuke Noda, Shinsuke Miyahara, Mine Harada, Shigeru Kinoshita, Ali Hafezi-Moghadam, Tatsuro Ishibashi, Joan W. Miller

BRITISH JOURNAL OF OPHTHALMOLOGY　91　(4)　520-526　2007/04

DOI： 10.1136/bjo.2006.102046 　

ISSN： 0007-1161

eISSN： 1468-2079
Pretreatment of posterior subtenon injection of triamcinolone acetonide has beneficial effects for grid pattern photocoagulation against diffuse diabetic macular oedema Peer-reviewed

Masahiko Shimura, Toru Nakazawa, Kanako Yasuda, Takashi Shiono, Kohji Nishida

BRITISH JOURNAL OF OPHTHALMOLOGY　91　(4)　449-454　2007/04

DOI： 10.1136/bjo.2006.106336 　

ISSN： 0007-1161

eISSN： 1468-2079
NMDA-induced interleukin-1 beta expression is mediated by nuclear factor-kappa B p65 in the retina Peer-reviewed

Yasushi Kitaoka, Yasunari Munemasa, Toru Nakazawa, Satoki Ueno

BRAIN RESEARCH　1142　247-255　2007/04

DOI： 10.1016/j.brainres.2007.01.097 　

ISSN： 0006-8993
Panretinal-Photocoagulation before Pars Plana Vitrectomy Influences Vitreous Level of Interleukin-6 but not of Vascular Endothelial Growth Factor in Patients with Diabetic Retinopathy. Peer-reviewed

Shimura M, Yasuda K, Nakazawa T, Shiono T, Nishida K

International journal of biomedical science : IJBS　3　(1)　31-37　2007/03

ISSN： 1550-9702
VLA-4 blockade suppresses endotoxin-induced uveitis: in vivo evidence for functional integrin up-regulation Peer-reviewed

A. Hafezi-Moghadam, K. Noda, L. Almulki, E. F. Ilmaki, V. Poulaki, K. L. Thomas, T. Nakazawa, T. Hisatomi, J. W. Miller, E. S. Gragoudas

FASEB JOURNAL　21　(2)　464-474　2007/02

DOI： 10.1096/fj.06-6390com 　

ISSN： 0892-6638
Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment Peer-reviewed

Toru Nakazawa, Hidetoshi Takahashi, Kazuaki Nishijima, Masahiko Shimura, Nobuo Fuse, Makoto Tamai, Ali Hafezi-Moghadam, Kohji Nishida

JOURNAL OF NEUROCHEMISTRY　100　(4)　1018-1031　2007/02

DOI： 10.1111/j.1471-4159.2006.04274.x 　

ISSN： 0022-3042
Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis Peer-reviewed

Toru Nakazawa, Toshio Hisatomi, Chifuyu Nakazawa, Kosuke Noda, Kazuichi Maruyama, Haicheng She, Akihisa Matsubara, Shinsuke Miyahara, Shintaro Nakao, Yuqin Yin, Larry Benowitz, Ali Hafezi-Moghadam, Joan W. Miller

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　104　(7)　2425-2430　2007/02

DOI： 10.1073/pnas.0608167104 　

ISSN： 0027-8424
Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma Peer-reviewed

Toru Nakazawa, Chifuyu Nakazawa, Akihisa Matsubara, Kousuke Noda, Toshio Hisatomi, Haicheng She, Norman Michaud, Ali Hafezi-Moghadam, Joan W. Miller, Larry I. Benowitz

JOURNAL OF NEUROSCIENCE　26　(49)　12633-12641　2006/12

DOI： 10.1523/JNEUROSCI.2801-06.2006 　

ISSN： 0270-6474
Characterization of cytokine responses to retinal detachment in rats Peer-reviewed

Toru Nakazawa, Akihisa Matsubara, Kousuke Noda, Toshio Hisatomi, Haicheng She, Dimitra Skondra, Shinsuke Miyahara, Lucia Sobrin, Kennard L. Thomas, Dong F. Chen, Cynthia L. Grosskreutz, Ali Hafezi-Moghadam, Joan W. Miller

MOLECULAR VISION　12　(97-98)　867-878　2006/08

ISSN： 1090-0535
The effect of unoprostone isopropyl on Ca2+ release-activated Ca2+ currents in cultured monkey trabecular meshwork cells and ciliary muscle cells Peer-reviewed

Masahiko Shimura, Kanako Yasuda, Toru Nakzawa, Kenji Kashiwagi

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS　22　(4)　219-226　2006/08

ISSN： 1080-7683

eISSN： 1557-7732
Neuroprotective effect of latanoprost on rat retinal ganglion cells Peer-reviewed

Hideyo Kudo, Toru Nakazawa, Masahiko Shimura, Hidetoshi Takahashi, Nobuo Fuse, Kenji Kashiwagi, Makoto Tamai

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　244　(8)　1003-1009　2006/08

DOI： 10.1007/s00417-005-0215-0 　

ISSN： 0721-832X
Visual function with acupuncture tested by visual evoked potential Peer-reviewed

Yoshiko Sagara, Nobuo Fuse, Motohiko Seimiya, Syunji Yokokura, Kei Watanabe, Toru Nakazawa, Masayuki Kurusu, Takashi Seki, Makoto Tamai

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　209　(3)　235-241　2006/07

DOI： 10.1620/tjem.209.235 　

ISSN： 0040-8727

eISSN： 1349-3329
Investigating the effect of ciliary body photodynamic therapy in a glaucoma mouse model Peer-reviewed

A Matsubara, T Nakazawa, D Husain, E Iliaki, E Connolly, NA Michaud, ES Gragoudas, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　47　(6)　2498-2507　2006/06

DOI： 10.1167/iovs.05-0959 　

ISSN： 0146-0404
Estrogen has a neuroprotective effect on axotomized RGCs through ERK signal transduction pathway Peer-reviewed

Toru Nakazawa, Hidetoshi Takahashi, Masahiko Shimura

BRAIN RESEARCH　1093　(1)　141-149　2006/06

DOI： 10.1016/j.brainres.2006.03.084 　

ISSN： 0006-8993

eISSN： 1872-6240
Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells Peer-reviewed

YQ Yin, MT Henzl, B Lorber, T Nakazawa, TT Thomas, F Jiang, R Langer, LI Benowitz

NATURE NEUROSCIENCE　9　(6)　843-852　2006/06

DOI： 10.1038/nn1701 　

ISSN： 1097-6256
Dose-dependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularization Peer-reviewed

HJ Zambarakji, T Nakazawa, E Connolly, AM Lane, S Mallemadugula, M Kaplan, N Michaud, A Hafezi-Moghadam, ES Gragoudas, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　47　(6)　2623-2631　2006/06

DOI： 10.1167/iovs.05-0855 　

ISSN： 0146-0404
N-Methyl-D-Aspartic acid suppresses Akt activity through protein phosphatase in retinal ganglion cells Peer-reviewed

T Nakazawa, M Shimura, S Endo, H Takahashi, N Mori, M Tamai

MOLECULAR VISION　11　(135)　1173-1182　2005/12

ISSN： 1090-0535
Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy Peer-reviewed

T Nakazawa, H Morii, M Tamai, N Mori

BRAIN RESEARCH　1061　(2)　97-106　2005/11

DOI： 10.1016/j.brainres.2005.08.055 　

ISSN： 0006-8993
Acupuncture for patients with glaucoma Peer-reviewed

Masayuki Kurusu, Kei Watanabe, Toru Nakazawa, Takashi Seki, Hiroyuki Arai, Hidetada Sasaki, Nobuo Fuse, Makoto Tamai

EXPLORE-THE JOURNAL OF SCIENCE AND HEALING　1　(5)　372-376　2005/09

DOI： 10.1016/j.explore.2005.06.007 　

ISSN： 1550-8307
Visual dysfunction after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision Peer-reviewed

M Shimura, K Yasuda, T Nakazawa, M Tamai

AMERICAN JOURNAL OF OPHTHALMOLOGY　140　(1)　8-15　2005/07

DOI： 10.1016/j.ajo.2005.02.029 　

ISSN： 0002-9394
Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases Peer-reviewed

T Nakazawa, E Endo, M Shimura, M Kondo, S Ueno, M Tamai

MOLECULAR BRAIN RESEARCH　135　(1-2)　58-68　2005/04

DOI： 10.1016/j.molbrainres.2004.12.006 　

ISSN： 0169-328X
Deleted in polyposis 1-like 1 gene (Dp1l1): A novel gene richly expressed in retinal ganglion cells Peer-reviewed

H Sato, H Tomita, T Nakazawa, S Wakana, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　(3)　791-796　2005/03

DOI： 10.1167/iovs.04-0867 　

ISSN： 0146-0404
Investigating the effect of ciliary body photodyanmic therapy in a glaucoma mouse model Peer-reviewed

A Matsubara, T Nakazawa, D Husain, EJ Connolly, N Michaud, ES Gragoudas, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　(6)　2498-2507　2005

DOI： 10.1167/iovs.05-0959 　

ISSN： 0146-0404
Characterization of cytokine responses to retinal detachment in rats Peer-reviewed

T Nakazawa, A Matsubara, DF Chen, L Sobrin, K Noda, D Skondra, CL Grosskreutz, A Hafezi-Moghadam, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　867-878　2005

ISSN： 0146-0404
眼科領域における周手術期での安静度の検討日常生活動作が及ぼす眼窩部への振動

永井加奈子, 大瀧保明, 志村雅彦, 中澤徹, 永富良一

眼科臨床医報　98　(10)　868-872　2004/10
Publisher: 眼科臨床医報会
ISSN： 0386-9601
Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population Peer-reviewed

N Fuse, K Takahashi, H Akiyama, T Nakazawa, M Seimiya, S Kuwahara, M Tamai

JOURNAL OF GLAUCOMA　13　(4)　299-303　2004/08

DOI： 10.1097/00061198-200408000-00007 　

ISSN： 1057-0829
Effective treatment of diffuse diabetic macular edema by temporal grid pattern photocoagulation Peer-reviewed

M Shimura, K Yasuda, T Nakazawa, S Ota, M Tamai

OPHTHALMIC SURGERY LASERS & IMAGING　35　(4)　270-280　2004/07

ISSN： 1542-8877

eISSN： 1938-2375
[Two cases of orbital myositis with monoclonal gammopathy of undetermined significance]. Peer-reviewed

Nakazawa T, Yamaguchi K, Nakagawa Y, Suzuki K, Takahashi H, Tamai M

Nippon Ganka Gakkai zasshi　108　(2)　110-117　2004/02

ISSN： 0029-0203
Quantifying alterations of macular thickness before and after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision Peer-reviewed

M Shimura, K Yasuda, T Nakazawa, T Kano, S Ohta, M Tamai

OPHTHALMOLOGY　110　(12)　2386-2394　2003/12

DOI： 10.1016/j.ophtha.2003.05.008 　

ISSN： 0161-6420
Expression and functional properties of unique inward rectifier K+ channel Kir7.1 in the porcine iris and retinal pigment epithelium Peer-reviewed

K Yasuda, M Shimura, T Nakazawa, H Sato, H Tomita, E Sugano, M Tamai

CURRENT EYE RESEARCH　27　(5)　279-287　2003/11

DOI： 10.1076/ceyr.27.5.279.17226 　

ISSN： 0271-3683
Clinical features of bilateral acute idiopathic maculopathy Peer-reviewed

T Nakazawa, K Yamaguchi, M Shimura, M Yoshida, Y Yoshioka, M Tamai

JAPANESE JOURNAL OF OPHTHALMOLOGY　47　(4)　385-391　2003/07

DOI： 10.1016/S0021-5155(03)00043-1 　

ISSN： 0021-5155
Evaluation of visual function in advanced glaucoma using a low vision evaluator stimulated with red, blue and green lights

Kana Takahashi, Yoichi Nakagawa, Soichiro Kuwahara, Nobuo Fuse, Hiroshi Akiyama, Toru Nakazawa, Yumiko Ban, Makoto Tamai

Japanese Journal of Clinical Ophthalmology　57　(7)　1257-1260　2003

ISSN： 0370-5579
Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury Peer-reviewed

T Nakazawa, M Shimura, H Tomita, H Akiyama, Y Yoshioka, H Kudou, M Tamai

CURRENT EYE RESEARCH　26　(1)　55-63　2003/01

DOI： 10.1076/ceyr.26.1.55.14254 　

ISSN： 0271-3683
Presence of mitogen-activated protein kinase in retinal Muller cells and its neuroprotective effect ischemia-reperfusion injury Peer-reviewed

H Akiyama, T Nakazawa, M Shimura, H Tomita, M Tamai

NEUROREPORT　13　(16)　2103-2107　2002/11

DOI： 10.1097/00001756-200211150-00022 　

ISSN： 0959-4965
Mitogen-activated protein kinase inhibitor, PD98059, inhibits rat retinal pigment epithelial cell replication by cell cycle arrest Peer-reviewed

K Yamaguchi, H Tomita, E Sugano, T Nakazawa, M Tamai

JAPANESE JOURNAL OF OPHTHALMOLOGY　46　(6)　634-639　2002/11

DOI： 10.1016/S0021-5155(02)00618-4 　

ISSN： 0021-5155
Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathways Peer-reviewed

T Nakazawa, M Tamai, N Mori

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　43　(10)　3319-3326　2002/10

ISSN： 0146-0404
Nipradilol inhibits apoptosis by preventing the activation of caspase-3 via S-nitrosylation and the cGMP-dependent pathway Peer-reviewed

H Tomita, T Nakazawa, E Sugano, T Abe, M Tamai

EUROPEAN JOURNAL OF PHARMACOLOGY　452　(3)　263-268　2002/10

DOI： 10.1016/S0014-2999(02)02329-4 　

ISSN： 0014-2999
Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine adapters during retinal development: Potential roles of N-Shc/ShcC in brain-derived neurotrophic factor signal transduction and modulation Peer-reviewed

T Nakazawa, Nakano, I, M Sato, T Nakamura, M Tamai, N Mori

JOURNAL OF NEUROSCIENCE RESEARCH　68　(6)　668-680　2002/06

DOI： 10.1002/jnr.10259 　

ISSN： 0360-4012

eISSN： 1097-4547
Neuroprotective effect of nipradilol on axotomized rat retinal ganglion cells Peer-reviewed

T Nakazawa, H Tomita, K Yamaguchi, Y Sato, M Shimura, S Kuwahara, M Tamai

CURRENT EYE RESEARCH　24　(2)　114-122　2002

DOI： 10.1076/ceyr.24.2.114.8162 　

ISSN： 0271-3683
Magnetic resonance imaging of a non-pigmented adenoma of the ciliary epithelium Peer-reviewed

T Nakazawa, T Abe, Y Sato, F Yuda, M Omura, M Tamai

ACTA OPHTHALMOLOGICA SCANDINAVICA　78　(4)　470-473　2000/08

ISSN： 1395-3907
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues Peer-reviewed

T Furuyama, T Nakazawa, Nakano, I, N Mori

BIOCHEMICAL JOURNAL　349　(Pt 2)　629-634　2000/07

DOI： 10.1042/0264-6021:3490629 　

ISSN： 0264-6021
The SCG10-related gene family in the developing rat retina: Persistent expression of SCLIP and stathmin in mature ganglion cell layer Peer-reviewed

T Nakazawa, Nakano, I, T Furuyama, H Morii, M Tamai, N Mori

BRAIN RESEARCH　861　(2)　399-407　2000/04

DOI： 10.1016/s0006-8993(00)02056-4 　

ISSN： 0006-8993
Varicella zoster-associated optic neuropathy with choroidal involvement Peer-reviewed

T Nakazawa, T Abe, M Ohmura

NEURO-OPHTHALMOLOGY　21　(1)　39-45　1999/02

DOI： 10.1076/noph.21.1.39.3923 　

ISSN： 0165-8107
Optic disc edema associated with spinocerebellar degeneration Peer-reviewed

T Nakazawa, T Abe, T Hasegawa, M Tamai

OPHTHALMOLOGICA　212　(4)　281-283　1998/07

DOI： 10.1159/000027308 　

ISSN： 0030-3755
全眼筋麻痺を伴った眼部帯状疱疹の1例

中澤徹

臨眼　52　1933-1937　1998
Identification of resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation. Br J Ophthalmol 2007; 91(4): 520-6. Peer-reviewed

Hisatomi T, Sonoda KH, Ishikawa F, Qiao H, Nakazawa T, Fukata M, Nakamura T, Noda K, Miyahara S, Harada M, Kinoshita S, Hafezi-Moghadam A, Ishibashi T, Miller JW

Show all ︎Show first 5

Misc. 905

Development of automatic eye drop device using airflow conveyance Peer-reviewed

道下史也, 中野康汰, 山路倍弘, 安永弘樹, 内田惠子, 橋本和軌, 中澤徹, 内田裕久

医療機器学　95　(1)　12-19　2025/02

ISSN： 1882-4978
不特定の利用者に対応可能なエアー搬送式自動点眼装置

AMRITA Bayarsaikhan, 近藤大智, 松平倖宜, 内田裕久, 内田惠子, 中澤徹

医療機器学　95　(2)　2025

ISSN： 1882-4978
仰臥位で使用する重力落下方式を用いた自動点眼装置の試作

松平倖宜, AMRITA Bayarsaikhan, 内田裕久, 内田惠子, 中澤徹

医療機器学　95　(2)　2025

ISSN： 1882-4978
RFIDと電子はかりを用いた医薬品使用モニタ装置の改善とクラウドサービス利用

加藤尚弥, 西田汰靖, 内田裕久, 内田惠子, 中澤徹

医療機器学　95　(2)　2025

ISSN： 1882-4978
Evaluation of the Sensitivity of Central Visual Field within 10 Degrees in Open Angle Glaucoma Using ”Strip” Images

杉田直紀, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　129　(5)　2025

ISSN： 0029-0203
Airflow-Assisted Automatic Eye Drop Device for Forward-Facing Posture: Behavior of Droplets

内田裕久, 道下史也, BAYARUSAIKHAN Amrita, 内田惠子, 中澤徹

Bio Industry　42　(5)　2025

ISSN： 0910-6545
シクロペントラート点眼調節麻痺下屈折検査を行った岩沼市小学校1~3年生の近視調査

藤岡俊亮, 藤岡俊亮, 吉田清香, 檜森紀子, 池田幸子, 宮武博, 板橋俊隆, 中澤徹

眼科臨床紀要　18　(3)　2025

ISSN： 1882-5176
糖尿病患者における黄斑体積と脂質ならびに酸化ストレスとの関連

岡部達, 國方彦志, 安田正幸, 中澤徹

日本糖尿病眼学会総会講演抄録集　31st　2025
Presbyopia and Ocular Anti-Aging: Anti-aging for the eyes: part 3: Glaucoma

檜森紀子, 中澤徹

臨床眼科　79　(1)　69-75　2025
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
RFIDと電子はかりを用いた医薬品使用モニタ装置の開発

加藤尚弥, 安永弘樹, 内田惠子, 中澤徹, 内田裕久

医療機器学　94　(6)　603-609　2024/12
Publisher: (一社)日本医療機器学会
ISSN： 1882-4978

eISSN： 1884-054X
Current advances in OCT angiography for glaucoma management

高橋直樹, 中澤徹

眼科　66　(13)　1611-1617　2024/12
Publisher: 金原出版(株)
ISSN： 0016-4488
【ザ・脈絡膜。】脈絡膜と緑内障

清田直樹, 高橋直樹, 中澤徹

臨床眼科　78　(12)　1359-1365　2024/11
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
滲出型加齢黄斑変性に対する抗VEGF薬投与前後の眼血流評価

瀧澤廣輝, 安田正幸, 國方彦志, 星佳佑, 岡部達, 新田文彦, 中澤徹

眼科臨床紀要　17　(11)　837-837　2024/11
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
【眼科外来診療-クリニックでの対応と紹介のタイミング-】緑内障 10歳代で正常眼圧の前視野緑内障が疑われる患者への治療方針

佐藤正隆, 中澤徹

眼科　66　(11)　1199-1203　2024/11
Publisher: 金原出版(株)
ISSN： 0016-4488
羞明により生活に支障をきたしている症例に対するacunisサングラスの使用経験

福岡世理, 竹下孝之, 高橋久美子, 竹内雅史, 津田聡, 中澤徹

日本視能矯正学会プログラム抄録集　65回　56-56　2024/11
Publisher: 日本視能矯正学会
The Choroid: The association of choroid with glaucoma pathophysiology

清田直樹, 高橋直樹, 中澤徹

臨床眼科　78　(12)　1359-1365　2024/11
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
Formula-Driven Data Augmentation and Partial Retinal Layer Copying for Retinal Layer Segmentation

Tsubasa Konno, Takahiro Ninomiya, Kanta Miura, Koichi Ito, Noriko Himori, Parmanand Sharma, Toru Nakazawa, Takafumi Aoki

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)　15188 LNCS　136-145　2024/10/02

DOI： 10.1007/978-3-031-73119-8_14 　

ISSN： 0302-9743

eISSN： 1611-3349
網膜中心動脈閉塞症とカルパイン阻害薬の臨床試験

國方彦志, 津田聡, 中澤徹

臨床眼科　78　(10)　1187-1192　2024/10
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
わかる! 身につく! 健康力加齢とともに増える目の病気

中澤徹

へるすあっぷ21　(480)　43-49　2024/10
Publisher: 東京 : 法研
Clinical trials of calpain inhibitors for central retinal artery occlusion

國方彦志, 津田聡, 中澤徹

臨床眼科　78　(10)　1187-1192　2024/10
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
緑内障関連遺伝子研究班の活動報告

中澤徹

日本緑内障学会抄録集　35回　48-48　2024/09
Publisher: 日本緑内障学会
正常眼圧緑内障における角膜ヒステレシスと視神経乳頭周囲網膜神経線維層厚の関連の検討

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　70-70　2024/09
Publisher: 日本緑内障学会
開放隅角緑内障における乳頭黄斑神経線維束厚と中心視野との関連に影響する因子

杉田直紀, 高橋直樹, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　70-70　2024/09
Publisher: 日本緑内障学会
眼底写真の緑内障スクリーニングAIを用いた市民イベントでの検証

二宮高洋, 檜森紀子, Parmanand Sharma, 鈴木啓太, 木川勉, 野口祥太郎, 野崎貴成, 藤原啓, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　76-76　2024/09
Publisher: 日本緑内障学会
網膜投影技術を用いたセルフ視野チェッカーMEOCHECKの有用性

津田聡, 石川誠, 矢花武史, 宮武博, 西村尭幸, 鈴木誠, 菅原充, 森野誠治, 横山悠, 檜森紀子, 中澤徹

日本緑内障学会抄録集　35回　83-83　2024/09
Publisher: 日本緑内障学会
世界緑内障週間における東北大学のライトアップinグリーン運動の取り組み

檜森紀子, 山口知暁, 星佳佑, 岡部達, 橋本和軌, 矢花武史, 石川誠, 國方彦志, 中澤徹

日本緑内障学会抄録集　35回　159-159　2024/09
Publisher: 日本緑内障学会
目磨き文化の醸成として緑内障啓発活動の試み

檜森紀子, 遠藤雅俊, 松原雄介, 稲穂健市, 矢花武史, 石川誠, 國方彦志, 中澤徹

あたらしい眼科　41　(7)　837-842　2024/07
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
光干渉断層計による統合失調症の網膜厚および血管密度の解析研究潜在的バイオマーカーとしての網膜

小松浩, 小野口豪, 矢花武史, 佐熊惇, 宮武博, 中澤徹, 富田博秋

精神神経学雑誌　(2024特別号)　S560-S560　2024/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
光干渉断層計による統合失調症の網膜厚および血管密度の解析研究潜在的バイオマーカーとしての網膜

小松浩, 小野口豪, 矢花武史, 佐熊惇, 宮武博, 中澤徹, 富田博秋

精神神経学雑誌　120th　(2024特別号)　S560-S560　2024/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
1%ドルゾラミド点眼後に漿液性網膜剥離が消失した視神経乳頭コロボーマの1例

藤岡俊亮, 吉田清香, 檜森紀子, 竹下孝之, 内田惠子, 山田晃生, 中澤徹, 野呂充

眼科臨床紀要　17　(6)　493-493　2024/06
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
The Impact of Heart Failure on Longitudinal Changes in White Matter Hyperintensities: Insights from B-HeFT 2 Study(タイトル和訳中)

菅野愛, 鈴木秀明, 黒澤亮, 武内広樹, 井上巧, 新井真理奈, 林秀華, 後岡広太郎, 高濱博幸, 中澤徹, 伊藤薫, 安田聡

日本循環器学会学術集会抄録集　88回　PJ118-1　2024/03
Publisher: (一社)日本循環器学会
To evaluate ocular blood flow of optic neuritis using laser speckle flowgraphy

山口知暁, 檜森紀子, 檜森紀子, 清田直樹, 大島隆寛, 木村瞭, 津田聡, 面高宗子, 三須建郎, 青木正志, 中澤徹

日本眼科学会雑誌　128　(臨増)　193-193　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Upregulated ER beta signaling attenuates inflammation in Nrf2 KO Mueller cells

内田惠子, 檜森紀子, 檜森紀子, 吉田真彰, 俵山寛司, 佐藤孝太, 中澤徹

日本眼科学会雑誌　128　(臨増)　204-204　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Development of SLO using semiconductor lasers

瀧澤廣輝, 矢花武史, 佐藤正隆, 二宮高洋, KAUSHIK Neelam, PARMANAND Sharma, 檜森紀子, 森野誠治, 鈴木誠, 石川誠, 國方彦志, 中澤徹

日本眼科学会雑誌　128　(臨増)　211-211　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Postoperative prediction by automatic extraction program with PS-OCT

村上真之, 津田聡, 吉田真彰, 國分太貴, 山成正宏, 岡本道明, SUCHANDRA Banarjee, 横山悠, 矢花武史, 前川重人, 檜森紀子, 中澤徹

日本眼科学会雑誌　128　(臨増)　248-248　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜投影技術を用いた簡易視野測定装置MEOCHECKによる白内障評価の追加解析

中島匡, 矢花武史, 佐藤正隆, 二宮高洋, 山崎舞, 津田聡, 檜森紀子, 横山悠, 森野誠治, 鈴木誠, 石川誠, 國方彦志, 中澤徹

日本眼科学会雑誌　128　(臨増)　274-274　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Additional analysis of cataract evaluation using retinal projection technology

中島匡, 矢花武史, 佐藤正隆, 二宮高洋, 山崎舞, 山崎舞, 津田聡, 檜森紀子, 横山悠, 森野誠治, 鈴木誠, 石川誠, 國方彦志, 中澤徹

日本眼科学会雑誌　128　(臨増)　274-274　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
心不全が大脳白質病変の変化に及ぼす影響:液性因子に関わる縦断観察研究

菅野愛, 鈴木秀明, 黒澤亮, 武内広樹, 井上巧, 林秀華, 後岡広太郎, 高濱博幸, 中澤徹, 伊藤薫, 安田聡

日本心臓病学会学術集会(Web)　72nd　2024
視覚障害を持つ子供と若者の視機能質問票FVQ_CYPの日本語版作成と検証に関する研究

高津育美, 高津育美, 高津育美, 鈴鴨よしみ, 宮武ミドリ, 鎌田さや花, 森隆史, 野呂充, 中澤徹, 海老原覚

日本ロービジョン学会学術総会プログラム・抄録集　25th　2024
1D+2D U-Netを用いた緑内障OCT評価の可能性の検討

二宮高洋, 近野翼, 檜森紀子, 檜森紀子, 伊藤康一, 高橋直樹, PARMANAND Sharma, 青木孝文, 中澤徹

日本眼科AI学会総会抄録集　5th　2024
動脈炎性前部虚血性視神経症におけるLaser Speckle Flowgraphyの有用性

山口知暁, 檜森紀子, 檜森紀子, 清田直樹, 大島隆寛, 竹下孝之, 津田聡, 面高宗子, 中澤徹

日本眼循環学会講演抄録集　40th　2024
滲出型加齢黄斑変性に対する抗VEGF療法後の薬剤別眼血流評価

瀧澤廣輝, 安田正幸, 新田文彦, 國方彦志, 中澤徹

日本眼循環学会講演抄録集　40th　2024
Nuanced relationships between lifestyle factors and eye diseases: Blood pressure and pulse rate management in primary open-angle glaucoma

清田直樹, 山口知暁, 中澤徹

臨床眼科　78　(13)　2024

ISSN： 0370-5579
眼科外来診療-クリニックでの対応と紹介のタイミング-III 緑内障 3 10歳代で正常眼圧の前視野緑内障が疑われる患者への治療方針

佐藤正隆, 中澤徹

眼科　66　(11)　1199-1203　2024
Publisher: 金原出版(株)
ISSN： 0016-4488
父母と小児の眼科的検査値の関連三世代コホート調査

石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 宇留野晃, 吉田清香, 高田菜生子, 藤岡俊亮, 西村尭幸, 中澤徹, 布施昇男, 栗山進一

Journal of Epidemiology　34　(Suppl.)　172-172　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
フェイキックIOL,LASIKにより水疱性角膜症と色素性緑内障をきたした1例

細越澤睦章, 針谷威寛, 小林航, 永澤拓也, 桐山卓也, 吉田真彰, 矢花武史, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　48th-40th　2024
取り上げ検出と重さ変化による医薬品使用モニタ装置の試作

加藤尚弥, 安永弘樹, 内田裕久, 内田惠子, 中澤徹

医療機器学　94　(2)　213-213　2024
Publisher: (一社)日本医療機器学会
ISSN： 1882-4978

eISSN： 1884-054X
エアー搬送を用いた自動点眼装置における点眼確率の向上

内田裕久, 道下史也, 中野康汰, 松平倖宜, 安永弘樹, 内田惠子, 中澤徹

医療機器学　94　(2)　212-212　2024
Publisher: (一社)日本医療機器学会
ISSN： 1882-4978

eISSN： 1884-054X
Biomarker discovery of glaucoma by the lipidomic profiling of extracellular vesicles in aquas humor

西原詩織, 佐藤孝太, 藤岡周, 横山悠, 福内友子, 山岡法子, 中澤徹, 三枝大輔, 三枝大輔

日本薬学会年会要旨集(Web)　144th　2024

ISSN： 0918-9823
Comparison of Superior and Inferior Microvasculature Dropout in Glaucoma

高橋哲, 高橋直樹, 津田聡, 面高宗子, 中澤徹

日本眼科学会雑誌　128　(臨増)　219-219　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Association between disc hemorrhage and optic nerve head blood flow in glaucoma

高橋直樹, 面高宗子, 羽入田明子, 武田瑶子, 津田聡, 中澤徹

日本眼科学会雑誌　128　(臨増)　219-219　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Neuroprotective effect of hexokinase 2 against optic nerve injured mice

佐藤孝太, 大石路子, 林宏亮, 中澤徹

日本眼科学会雑誌　128　(臨増)　203-203　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Characteristics of Initial ERG in Acute Retinal Necrosis

福山俊一, 橋本和軌, 吉田真彰, 牛田宏昭, 橋田徳康, 中澤徹, 西口康二, 丸山和一, 西田幸二

日本眼科学会雑誌　128　(臨増)　228-228　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Utility of Ocular Blood Flow Assessment for Visual-Field Defect Evaluation

清田直樹, 中澤徹

日本眼科学会雑誌　128　(臨増)　39-39　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Relationship between CH and optic nerve head blood flow measured by LSFG in OAG.

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本眼科学会雑誌　128　(臨増)　218-218　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Biological Age Prediction Using Retinal Images with Multi-Task Learning (MTL)

二宮高洋, SHARMA Parmanand, 羽入田明子, 鈴木啓太, 野崎貴成, 富山優介, 面高宗子, 市川陽一, 中澤徹

日本眼科学会雑誌　128　(臨増)　245-245　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
The Relationships between systemic inflammation response Index and RRD

安田正幸, 岡部達, 國方彦志, 二宮高洋, 宮武博, 星佳佑, 瀧澤廣輝, 中澤徹

日本眼科学会雑誌　128　(臨増)　271-271　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Relationship between brain volume and myopia in glaucoma patients using MRI

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　128　(臨増)　250-250　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Long-term prognosis of eyes with brolucizumab-associated IOI

星佳佑, 國方彦志, 安田正幸, 岡部達, 瀧澤廣輝, 中澤徹

日本眼科学会雑誌　128　(臨増)　210-210　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Association between central visual field and papillomacular bundle in OAG

杉田直紀, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　128　(臨増)　251-251　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Diagnosis of OAG by a machine learning model using specific autoantibodies

石川誠, 高田菜生子, 二宮高洋, 國方彦志, 羽入田明子, 福田枝里子, 山口圭, 小野千紘, 桐原朋子, 新谷千栄, 佐藤孝太, 五島直樹, 中澤徹

日本眼科学会雑誌　128　(臨増)　220-220　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Relationship between MRI hippocampus volume and OCTA parameters

高田菜生子, 橋本和軌, 二宮高洋, 前川重人, 石川誠, 國方彦志, 布施昇男, 麦倉俊司, 中澤徹

日本眼科学会雑誌　128　(臨増)　246-246　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Changes in NLRP3 modulated by microglia in a rat ex vivo glaucoma model

佐藤大夢, 石川誠, 大石路子, 神位りえ子, 佐藤孝太, 俵山寛司, 中澤徹

日本眼科学会雑誌　128　(臨増)　204-204　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Successful Lesion Excision in a Healthy Young Female with Iris Fungal Abscess

松本拓郎, 吉田真彰, 橋本和軌, 國方彦志, 中澤徹

日本眼科学会雑誌　128　(臨増)　227-227　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Risk Factors for Axial Length Elongation: A Population-Based Study in Japan

西村尭幸, 西村尭幸, 國方彦志, 高田菜生子, 石川誠, 千葉一平, 中谷直樹, 寶澤篤, 布施昇男, 中澤徹

日本眼科学会雑誌　128　(臨増)　233-233　2024
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
円錐角膜患者における視神経乳頭組織血流低下に関連する因子の検討

永澤拓也, 小林航, 宮武博, 山口知暁, 桐山卓也, 吉田真彰, 針谷威寛, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　48th-40th　2024
円錐角膜患者における視神経乳頭周囲網膜神経線維層厚と性別の関連

小林航, 永澤拓也, 二宮高洋, 宮武博, 桐山卓也, 桐山卓也, 吉田真彰, 針谷威寛, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　48th-40th　2024
Attempts to Raise Awareness of Glaucoma

檜森紀子, 檜森紀子, 遠藤雅俊, 遠藤雅俊, 松原雄介, 稲穂健市, 矢花武史, 石川誠, 國方彦志, 中澤徹

あたらしい眼科　41　(7)　837-842　2024
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
フックス角膜ジストロフィーに対する角膜内皮移植術の術後経過に影響を与える因子

針谷威寛, 小林航, 永澤拓也, 桐山卓也, 吉田真彰, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　48th-40th　2024
父母と小児の眼科的検査値の関連:三世代コホート調査

石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 宇留野晃, 吉田清香, 高田菜生子, 藤岡俊亮, 西村尭幸, 中澤徹, 布施昇男, 布施昇男, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　34th　(Suppl.)　172-172　2024
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
網膜層セグメンテーションのための網膜OCT画像のデータ拡張の検討

近野翼, 二宮高洋, 三浦幹太, 伊藤康一, 檜森紀子, SHARMA Parmanand, 中澤徹, 青木孝文

電子情報通信学会技術研究報告(Web)　124　(58(SIP2024 1-17))　2024

ISSN： 2432-6380
Review of seventeen cases of optic neuritis at Yonezawa City Hospital

高宮美智子, 佐久間大輔, 山口万里奈, 國方彦志, 中澤徹

臨床眼科　78　(4)　447-451　2024
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
A case of residual lens capsule transplantation and vitreous surgery for macular hole retinal detachment after secondary cataract treatment

新田文彦, 國方彦志, 佐々木栞菜, 小山内亜紀, 中澤徹

臨床眼科　78　(4)　479-484　2024
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
A study of lens tilt and decentration after intrascleral intraocular lens implantation

佐々木栞菜, 新田文彦, 小山内亜紀, 國方彦志, 中澤徹

臨床眼科　78　(4)　458-463　2024
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
COVID-19ワクチン接種後動眼神経麻痺の1例

吉田清香, 檜森紀子, 竹下孝之, 藤岡俊亮, 藤岡俊亮, 内田惠子, 山田晃生, 中澤徹

眼科臨床紀要　17　(3)　275-275　2024
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Apache Camelを用いた電子カルテシステムとの連携眼科病棟における点眼表作成アプリの試作

中村直毅, 中村香菜江, 片倉睦, 中澤徹, 大田英揮

医療情報学連合大会論文集　43回　857-858　2023/11
Publisher: (一社)日本医療情報学会
ISSN： 1347-8508

eISSN： 2433-698X
Apache Camelを用いた電子カルテシステムとの連携眼科病棟における点眼表作成アプリの試作

中村直毅, 中村香菜江, 片倉睦, 中澤徹, 大田英揮

医療情報学連合大会論文集　43回　857-858　2023/11
Publisher: (一社)日本医療情報学会
ISSN： 1347-8508

eISSN： 2433-698X
爪床毛細血管パラメータと非糖尿病網膜症の関係

岡部達, 安田正幸, 國方彦志, 高田菜生子, 前田雄大, 中野讓, 武野團, 中澤徹

眼科臨床紀要　16　(10)　732-733　2023/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Evaluation of intraocular hypertension after operation of rhegmatous retinal detachment

新田文彦, 國方彦志, 阿部俊明, 中澤徹

臨床眼科　77　(10)　1269-1274　2023/10
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
緑内障関連遺伝子研究班の活動報告

中澤徹

日本緑内障学会抄録集　34回　76-76　2023/09
Publisher: 日本緑内障学会
CDKN2B-AS1遺伝子変異における培養神経細胞株への生存率の影響

佐藤孝太, 大石路子, 菅野聖世, 鄒名愛, 河野ちひろ, 石川誠, 中澤徹

日本緑内障学会抄録集　34回　109-109　2023/09
Publisher: 日本緑内障学会
ラットex vivo緑内障モデルにおけるCSF1受容体阻害薬によるNLRP3介在型炎症反応抑制の検討

佐藤大夢, 石川誠, 大石路子, 神位りえ子, 佐藤孝太, 中澤徹

日本緑内障学会抄録集　34回　110-110　2023/09
Publisher: 日本緑内障学会
血漿プロテオーム解析による緑内障自己抗体の同定

高田菜生子, 石川誠, 佐藤孝太, 國方彦志, 福田枝里子, 山口圭, 小野千紘, 桐原朋子, 新谷千栄, 五島直樹, 中澤徹

日本緑内障学会抄録集　34回　110-110　2023/09
Publisher: 日本緑内障学会
開放隅角緑内障における角膜ヒステレシスと部位別に見た視神経乳頭周囲網膜神経線維層厚の関連の検討

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　34回　155-155　2023/09
Publisher: 日本緑内障学会
家庭における血圧や脈拍と緑内障との関連について

前川重人, 津田聡, 石川誠, 中澤徹

日本緑内障学会抄録集　34回　157-157　2023/09
Publisher: 日本緑内障学会
Association of ocular parameter with longitudinal change in regional brain volume in glaucoma by VBM

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　34回　163-163　2023/09
Publisher: 日本緑内障学会
Prediction of Sleep Apnea Syndrome Using Machine Learning in Patients with Open-Angle Glaucoma

山崎舞, 山崎舞, 檜森紀子, 檜森紀子, 二宮高洋, 清田直樹, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本緑内障学会抄録集　34回　197-197　2023/09
Publisher: 日本緑内障学会
The Study design and the progress report of the “Multicenter Ophthalmic Biobank”

横山悠, 佐藤孝太, 橋本和軌, 高橋直樹, 佐藤正隆, 高田菜生子, 中澤徹

日本緑内障学会抄録集　34回　223-223　2023/09
Publisher: 日本緑内障学会
急速な両眼視力低下と視野障害を来した胃癌髄膜癌腫症の1例

山口知暁, 檜森紀子, 西村尭幸, 内田恵子, 柳町真希, 竹下孝之, 谷口桜, 長谷川隆文, 石岡千加史, 中澤徹

神経眼科　40　(3)　254-259　2023/09
Publisher: 日本神経眼科学会
ISSN： 0289-7024

eISSN： 2188-2002
A Case of Meningeal Carcinomatosis of Gastric Cancer-causing Rapid Loss of Visual Acuity and Visual Field Defects in Both Eyes

山口知暁, 檜森紀子, 檜森紀子, 西村尭幸, 内田恵子, 柳町真希, 竹下孝之, 谷口桜, 谷口桜, 長谷川隆文, 石岡千加史, 中澤徹

神経眼科　40　(3)　254-259　2023/09
Publisher: 日本神経眼科学会
ISSN： 0289-7024

eISSN： 2188-2002
An annual report from Japanese Glaucoma Society Omics Group (JGS-OG)

中澤徹

日本緑内障学会抄録集　34回　76-76　2023/09
Publisher: 日本緑内障学会
Survival effects on CDKN2B-AS1 gene mutations in cultured neuronal cell lines

佐藤孝太, 大石路子, 菅野聖世, 鄒名愛, 河野ちひろ, 石川誠, 中澤徹

日本緑内障学会抄録集　34回　109-109　2023/09
Publisher: 日本緑内障学会
Study of CSF1R Inhibitor’s Suppression of NLRP3 inflammasome in an ex vivo Rat Glaucoma Model

佐藤大夢, 石川誠, 大石路子, 神位りえ子, 佐藤孝太, 中澤徹

日本緑内障学会抄録集　34回　110-110　2023/09
Publisher: 日本緑内障学会
Autoantibodies are biomarkers for diagnosis of openangle glaucoma in Japanese population

高田菜生子, 石川誠, 佐藤孝太, 國方彦志, 福田枝里子, 山口圭, 小野千紘, 桐原朋子, 新谷千栄, 五島直樹, 中澤徹

日本緑内障学会抄録集　34回　110-110　2023/09
Publisher: 日本緑内障学会
Sector Differences in Visual Field Associations with Intraocular Pressure Changes by Prone Test

佐藤正隆, 清田直樹, 矢花武史, 前川重人, 津田聡, 面高宗子, 檜森紀子, 横山悠, 中澤徹

日本緑内障学会抄録集　34回　148-148　2023/09
Publisher: 日本緑内障学会
Establishment of an automated evaluation system for follicular scarring using PS-OCT

村上真之, 津田聡, 吉田真彰, 國分太貴, 山成正宏, 岡本道明, 横山悠, 矢花武史, 前川重人, 檜森紀子, 中澤徹

日本緑内障学会抄録集　34回　155-155　2023/09
Publisher: 日本緑内障学会
Corneal Hysteresis and Peripapillary Retinal Nerve Fiber Layer Thickness in Open Angle Glaucoma

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　34回　155-155　2023/09
Publisher: 日本緑内障学会
Blood pressure and pulse in home for the diagnosis of glaucoma

前川重人, 津田聡, 石川誠, 中澤徹

日本緑内障学会抄録集　34回　157-157　2023/09
Publisher: 日本緑内障学会
Association of ocular parameter with longitudinal change in regional brain volume in glaucoma by VBM

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　34回　163-163　2023/09
Publisher: 日本緑内障学会
Influence of axial length on macular inner layer thickness in normal eyes and glaucoma eyes

竹本大輔, 東出朋巳, 宇田川さち子, 杉山和久, 三木篤也, 富田剛司, 齋藤瞳, 中澤徹, 大野京子, 岩瀬愛子, 新家眞

日本緑内障学会抄録集　34回　163-163　2023/09
Publisher: 日本緑内障学会
Prediction of Sleep Apnea Syndrome Using Machine Learning in Patients with Open-Angle Glaucoma

山崎舞, 山崎舞, 檜森紀子, 檜森紀子, 二宮高洋, 清田直樹, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本緑内障学会抄録集　34回　197-197　2023/09
Publisher: 日本緑内障学会
Attempts to raise awareness of glaucoma

檜森紀子, 檜森紀子, 遠藤雅俊, 遠藤雅俊, 松原雄介, 稲穂健市, 矢花武史, 石川誠, 國方彦志, 中澤徹

日本緑内障学会抄録集　34回　(7)　197-197　2023/09
Publisher: 日本緑内障学会
ISSN： 0910-1810
The Study design and the progress report of the “Multicenter Ophthalmic Biobank”

横山悠, 佐藤孝太, 橋本和軌, 高橋直樹, 佐藤正隆, 高田菜生子, 中澤徹

日本緑内障学会抄録集　34回　223-223　2023/09
Publisher: 日本緑内障学会
Summing up 視神経乳頭血流と篩状板の視点からの緑内障病態

中澤徹

Frontiers in Glaucoma　1　(66)　34-40　2023/08/30
Publisher: メディカルレビュー社
DOI： 10.34449/j0024.01.66_0034-0040 　

ISSN： 1345-854X
【アイケア～視機能・ピント調節・瞳の潤い～】「眼と健康」における緑内障の予防、早期発見の重要性

中澤徹

FOOD Style 21　27　(8)　36-38　2023/08
Publisher: (株)食品化学新聞社
ISSN： 1343-9502
Summing up 視神経乳頭血流と篩状板の視点からの緑内障病態

中澤徹

Frontiers in Glaucoma　(66)　102-108　2023/08
Publisher: (株)メディカルレビュー社
ISSN： 1345-854X
【眼科とサプリメント】わかりやすい臨床講座緑内障と酸化ストレス,抗酸化治療の試み

檜森紀子, 中澤徹

日本の眼科　94　(7)　838-843　2023/07
Publisher: (公社)日本眼科医会
ISSN： 0285-1326
専門分野の選び方,深め方

石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児

Retina Medicine　12　(1)　1-8　2023/04
Publisher: (株)先端医学社
ISSN： 2187-2384
エアー搬送と画像処理を利用した前向き点眼の自動化についての検討

中野康汰, 山路倍弘, 道下史也, 安永弘樹, 内田裕久, 内田恵子, 中澤徹

医療機器学　93　(2)　255-255　2023/04
Publisher: (一社)日本医療機器学会
ISSN： 1882-4978

eISSN： 1884-054X
専門分野の選び方,深め方

石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児

Retina Medicine　12　(1)　1-8　2023/04
Publisher: (株)先端医学社
ISSN： 2187-2384
若手の育成(基礎研究)

杉山和久, 稲谷大, 井上俊洋, 中澤徹

Frontiers in Glaucoma　(65)　25-32　2023/03
Publisher: (株)メディカルレビュー社
ISSN： 1345-854X
Investigation on the measurement method of choroidal microvascular dropout area

高橋直樹, 面高宗子, 木川勉, 二宮高洋, 清田直樹, 津田聡, 中澤徹

日本眼科学会雑誌　127　(臨増)　190-190　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
GPR84 is a marker of retinal microglia that highly express TNF/IL-1

佐藤孝太, 大石路子, 中澤徹

日本眼科学会雑誌　127　(臨増)　193-193　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Genetic characteristics of inherited retinal dystrophy in 2459 Japanese patients

後藤健介, 小柳俊人, 小柳俊人, 小柳俊人, 秋山雅人, 秋山雅人, 村上祐介, 福嶋正俊, 藤原康太, 飯島花枝, 山口光代, 橋本和軌, 石津正崇, 平形寿彬, 溝渕圭, 高山理和, 佐治木愛, 小南太郎, 牛田宏昭, 藤田幸輔, 兼子裕規, 上野真治, 上野真治, 林孝彰, 寺尾知可史, 堀田喜裕, 村上晶, 和田裕子, 阿部俊明, 中澤徹, 池田康博, 桃沢幸秀, 園田康平, 西口康二

日本眼科学会雑誌　127　(臨増)　199-199　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
近視性脈絡膜新生血管と血中潜在的抗酸化能の関連

王紀英, 安田正幸, 國方彦志, 岡部達, 星佳佑, 瀧澤廣輝, 中澤徹

日本眼科学会雑誌　127　(臨増)　213-213　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ウサギ眼における、ブリモニジン/ブリンゾラミド配合点眼剤の眼血流への影響について

高橋成奈, 佐藤孝太, 清田直樹, 中澤徹

日本眼科学会雑誌　127　(臨増)　216-216　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
正常眼圧緑内障患者における睡眠時無呼吸症候群のリスク因子の検討

山崎舞, 檜森紀子, 宮武博, 二宮高洋, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　127　(臨増)　220-220　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
心筋ストレスマーカーNT-proBNPと網膜表層血管密度との関連

橋本和軌, 國方彦志, 高田菜生子, 前川重人, 二宮高洋, Sharma Parmanand, 布施昇男, 麦倉俊司, 中澤徹

日本眼科学会雑誌　127　(臨増)　240-240　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
MMWNを介したAI開発基盤となる医療データ収集システムとAI診療サポートシステムの構築

横山悠, 竹田徳泰, 藤井進, 中村直毅, 井戸敬介, 桐山卓也, 大槻昌人, 木川勉, 荻島創一, 中澤徹

日本眼科学会雑誌　127　(臨増)　249-249　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Analysis of retinal energy metabolism and retinal function

阿部俊明, 大学玲子, 謝玉てい, 大学保一, 泉田泰子, 永井展裕, 國方彦志, 中澤徹

日本眼科学会雑誌　127　(臨増)　253-253　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Comparison of new color visual field test in PPG and normal eyes

佐藤裕之, 國方彦志, 田中芳樹, 面高宗子, 檜森紀子, 市川一夫, 中澤徹

日本眼科学会雑誌　127　(臨増)　266-266　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Innovation in Diagnosis and Treatment of Ocular Diseases by Applying Genomic Medicine

西口康二, 藤田幸輔, 小柳俊人, 佐治木愛, 川野健一, 山田和久, 川部満希, 奥田大志, 鈴村文那, 清水英幸, 牛田宏昭, 兼子裕規, 小松紘之, 臼井嘉彦, 後藤浩, 中澤徹, 加地秀

日本眼科学会雑誌　127　(3)　402-422　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Intraocular pressure dynamics during the prone position and the follow-up term

佐藤正隆, 清田直樹, 矢花武史, 前川重人, 津田聡, 面高宗子, 檜森紀子, 檜森紀子, 横山悠, 中澤徹

日本眼科学会雑誌　127　(臨増)　188-188　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Evaluation of usability and safety of a tonometer through the upper eyelid

山口万里奈, 津田聡, 山口明彦, 矢花武史, 山口知暁, 根本靖久, 中澤徹

日本眼科学会雑誌　127　(臨増)　189-189　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Investigation on the measurement method of choroidal microvascular dropout area

高橋直樹, 面高宗子, 木川勉, 二宮高洋, 清田直樹, 津田聡, 中澤徹

日本眼科学会雑誌　127　(臨増)　190-190　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Factors associated with sinkhole formation in intrachoroidal cavitation

山口知暁, 清田直樹, 高橋直樹, 武田瑶子, 佐藤正隆, 津田聡, 面高宗子, 中澤徹

日本眼科学会雑誌　127　(臨増)　190-190　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
GPR84 is a marker of retinal microglia that highly express TNF/IL-1

佐藤孝太, 大石路子, 中澤徹

日本眼科学会雑誌　127　(臨増)　193-193　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Expressional changes of NLRP3 in a rat ex vivo glaucoma model

佐藤大夢, 石川誠, 大石路子, 神位りえ子, 佐藤孝太, 中澤徹

日本眼科学会雑誌　127　(臨増)　193-193　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Genetic characteristics of inherited retinal dystrophy in 2459 Japanese patients

後藤健介, 小柳俊人, 小柳俊人, 小柳俊人, 秋山雅人, 秋山雅人, 村上祐介, 福嶋正俊, 藤原康太, 飯島花枝, 山口光代, 橋本和軌, 石津正崇, 平形寿彬, 溝渕圭, 高山理和, 佐治木愛, 小南太郎, 牛田宏昭, 藤田幸輔, 兼子裕規, 上野真治, 上野真治, 林孝彰, 寺尾知可史, 堀田喜裕, 村上晶, 和田裕子, 阿部俊明, 中澤徹, 池田康博, 桃沢幸秀, 園田康平, 西口康二

日本眼科学会雑誌　127　(臨増)　199-199　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Association between antioxidant capacity and mCNV

王紀永, 安田正幸, 國方彦志, 岡部達, 星佳祐, 瀧澤廣輝, 中澤徹

日本眼科学会雑誌　127　(臨増)　213-213　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
The effect of brimonidine/brinzolamide on ocular blood flow in rabbits

高橋成奈, 佐藤孝太, 清田直樹, 中澤徹

日本眼科学会雑誌　127　(臨増)　216-216　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
The risk factor of sleep apnea syndrome in normal tension glaucoma

山崎舞, 山崎舞, 檜森紀子, 檜森紀子, 宮武博, 二宮高洋, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　127　(臨増)　220-220　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Glaucoma Registry for use in the development of new treatments

阿部真以子, 津田聡, 和田信介, 横山悠, 檜森紀子, 矢花武史, 面高宗子, 前川重人, 高田菜生子, 山崎舞, 漆原尚巳, 中澤徹

日本眼科学会雑誌　127　(臨増)　221-221　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Relationship between NT-proBNP and retinal surface vessel density

橋本和軌, 國方彦志, 高田菜生子, 前川重人, 二宮高洋, PARMANAND Sharma, 布施昇男, 布施昇男, 麦倉俊司, 中澤徹

日本眼科学会雑誌　127　(臨増)　240-240　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Development of a medical data collection system and AI support system using MMWN

横山悠, 竹田徳泰, 藤井進, 藤井進, 中村直毅, 井戸敬介, 玉山卓也, 大槻昌人, 木川勉, 荻島創一, 中澤徹

日本眼科学会雑誌　127　(臨増)　249-249　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜エネルギー代謝と網膜機能の解析

阿部俊明, 大学玲子, 謝玉てい, 大学保一, 泉田泰子, 永井展裕, 國方彦志, 中澤徹

日本眼科学会雑誌　127　(臨増)　253-253　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
前視野緑内障眼に対する色視野検査の検討

佐藤裕之, 國方彦志, 田中芳樹, 面高宗子, 檜森紀子, 市川一夫, 中澤徹

日本眼科学会雑誌　127　(臨増)　266-266　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Association of disc hemorrhage and disc subtypes in normal tension glaucoma

武田瑶子, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　127　(臨増)　299-299　2023/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
若手の育成(基礎研究)

杉山和久, 稲谷大, 井上俊洋, 中澤徹

Frontiers in Glaucoma　(65)　25-32　2023/03
Publisher: (株)メディカルレビュー社
ISSN： 1345-854X
緑内障眼における傍乳頭脈絡膜微小血管脱落形成に関与する因子の検討

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本眼循環学会講演抄録集　39th　2023
視神経乳頭周囲組織血流に着目した緑内障における線維柱帯切除術後の視力低下

武田瑶子, 高橋直樹, 國分太貴, 津田聡, 面高宗子, 中澤徹

日本眼循環学会講演抄録集　39th　2023
Laser speckle flowgraphyを用いた視神経症の鑑別についての検討

山口知暁, 清田直樹, 檜森紀子, 津田聡, 面高宗子, 中澤徹

日本眼循環学会講演抄録集　39th　2023
緑内障患者における中心窩無血管域(FAZ)と視野障害および全身因子との関連

二宮高洋, 面高宗子, 清田直樹, PARMANAND Sharma, 檜森紀子, 檜森紀子, 安田正幸, 國方彦志, 中澤徹

日本眼循環学会講演抄録集　39th　2023
CRAOを対象としたカルパイン阻害薬SJP-0008の医師主導第IIa相試験

津田聡, 國方彦志, 橋本和軌, 浅野俊文, 伊藤梓, 國分太貴, 吉田光秀, 安田正幸, 中澤徹

日本眼循環学会講演抄録集　39th　2023
長期間の腎機能推移(Long-term eGFR plot)に立脚した潜在的腎予後不良症例の実態調査

中澤純, 廣坂雄介, 吉田尚平, 佐々木裕二, 高谷季穂, 荒牧陽, 大橋誠治, 川人浩之, 西山順博, 山田衆, 野村哲, 浜本徹, 芦原貴司, 久米真司

日本腎臓学会誌(Web)　65　(3)　2023

ISSN： 1884-0728
Integration with Electronic Medical Record System using Apache Camel-Prototype of an Eye-Drop Charting Application for an Ophthalmology Ward-

中村直毅, 中村香菜江, 片倉睦, 中澤徹, 大田英揮

医療情報学連合大会論文集(CD-ROM)　43rd　2023

ISSN： 2433-698X
重症糖尿病網膜症と全身炎症ならびに抗酸化能の関連

星佳佑, 安田正幸, 岡部達, 瀧澤廣輝, 二宮高洋, 宮武博, 國方彦志, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　62nd　(10)　763-764　2023
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
未熟児網膜症におけるラニビズマブ硝子体注射導入前後での臨床経過比較

新田文彦, 新田文彦, 國方彦志, 太田裕也, 渡邊真平, 内田俊彦, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　62nd　(10)　762-762　2023
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
裂孔原性網膜剥離と全身炎症マーカーの関連

安田正幸, 岡部達, 國方彦志, 二宮高洋, 宮武博, 星佳佑, 瀧澤廣輝, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　62nd　(10)　775-775　2023
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
滲出型加齢黄斑変性に対する抗VEGF薬投与前後の眼血流評価

瀧澤廣輝, 安田正幸, 國方彦志, 星佳佑, 岡部達, 新田文彦, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　62nd　(11)　837-837　2023
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
網膜疾患の過去・現在・未来~この10年で何が変わった?~緑内障

清田直樹, 中澤徹

Retina Medicine　12　(2)　113-117　2023
Publisher: (株)先端医学社
ISSN： 2187-2384
左右に異なる初回緑内障手術を施行した両眼サイトメガロウイルス陽性続発緑内障の一例

安達彩, 安達彩, 吉川真彰, 前川重人, 横山悠, 針谷威寛, 橋本和軌, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　59th-56th-65th-11th　2023
Study of a virtual enabler for the care of users with suspection of pre-symptomatic state

曾根周作, 曾根周作, 合澤典子, 二宮高洋, 高田菜生子, 嘉陽彩乃, 檜森紀子, 牛久祥孝, 牛久祥孝, 大森美香, 大森美香, 中澤徹, 乾健太郎, 乾健太郎

人工知能学会全国大会論文集(Web)　37th　2023

ISSN： 2758-7347
イノベーター理論からみるOCTの学産医の協創緑内障疾患のモニタリングとヘルスケア応用

中澤徹

日本眼光学学会総会プログラム・抄録集　59th　2023
エアー搬送と画像処理を利用した前向き点眼の自動化についての検討

中野康汰, 山路倍弘, 道下史也, 安永弘樹, 内田裕久, 内田恵子, 中澤徹

医療機器学　93　(2)　255-255　2023
Publisher: (一社)日本医療機器学会
ISSN： 1882-4978

eISSN： 1884-054X
AIとスマートフォンを用いた眼科画像解析モデルと網膜血管評価への可能性

中澤徹

糖尿病学の進歩　57th　2023
わかりやすい臨床講座緑内障と酸化ストレス,抗酸化治療の試み

檜森紀子, 中澤徹

日本の眼科　94　(7)　838-843　2023
Publisher: (公社)日本眼科医会
ISSN： 0285-1326
Association between cpRNFLT and AS-OCT parameters in patients with keratoconus

小林航, 横倉俊二, 桐山卓也, 吉田真彰, 針谷威寛, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　47th-39th　2023
Relationship between anterior segment and visual acuity in pterygium surgery

桐山卓也, 小林航, 山成正宏, 吉田真彰, 針谷威寛, 横倉俊二, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　47th-39th　2023
Characteristics of PCR positive cases in cytomegalovirus keratouveitis

針谷威寛, 吉田真彰, 桐山卓也, 小林航, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　47th-39th　2023
1D+2D U-Netを用いたOCT画像からの網膜層セグメンテーションの高精度化

近野翼, 二宮高洋, 三浦幹太, 伊藤康一, 檜森紀子, SHARMA Parmanand, 中澤徹, 青木孝文

電子情報通信学会技術研究報告(Web)　123　(96(MI2023 7-13))　2023

ISSN： 2432-6380
アイケア~視機能・ピント調節・瞳の潤い~「眼と健康」における緑内障の予防,早期発見の重要性

中澤徹

Food Style 21　27　(8)　36-38　2023
Publisher: (株)食品化学新聞社
ISSN： 1343-9502
Risk factors for glaucoma

國分太貴, 中澤徹

眼科　65　(1)　51-62　2023/01
Publisher: 金原出版(株)
ISSN： 0016-4488
薬事利用を目指した緑内障レジストリでの品質管理システムの設計および実装

和田信介, 津田聡, 阿部真以子, 中澤徹, 漆原尚巳

日本臨床薬理学会学術総会抄録集　43回　1-7　2022/12
Publisher: (一社)日本臨床薬理学会
ISSN： 2436-5580

eISSN： 2436-5580
急速な両眼視力低下と視野障害を来した胃癌髄膜癌腫症の1例

山口知暁, 檜森紀子, 西村尭幸, 内田恵子, 柳町真希, 竹下孝之, 谷口桜, 長谷川隆文, 石岡千加史, 中澤徹

神経眼科　39　(増補1)　86-86　2022/10
Publisher: 日本神経眼科学会
ISSN： 0289-7024

eISSN： 2188-2002
Annual report from Japanese Glaucoma Society Omics Group (JGS-OG)

中澤徹

日本緑内障学会抄録集　33回　48-48　2022/09
Publisher: 日本緑内障学会
Involvement of mTOR pathway in hydrostatic pressure loading on hiPSCs-derived 3D retinal organoids

小林航, 吉野大輔, 増田智浩, 大西暁士, 継田美里, 堺香名子, 小椋利彦, 中澤徹

日本緑内障学会抄録集　33回　80-80　2022/09
Publisher: 日本緑内障学会
Investigation for Neuroprotective effects of overexpression of carnitine acetyltransferase

佐藤孝太, 藤岡周, DONG Xiaoxuan, 前川重人, 中澤徹

日本緑内障学会抄録集　33回　81-81　2022/09
Publisher: 日本緑内障学会
Glial cells modulate retinal cell survival in rotenone-induced neural degeneration

柳町真希, 俵山寛司, 俵山寛司, 檜森紀子, 檜森紀子, 中澤徹, 中澤徹

日本緑内障学会抄録集　33回　81-81　2022/09
Publisher: 日本緑内障学会
Changes in Retinal Microglia during Intraocular Pressure Elevation in Ex Vivo Rat Model of Glaucoma

佐藤大夢, 石川誠, 大石路子, 神位りえ子, 佐藤孝太, 中澤徹

日本緑内障学会抄録集　33回　83-83　2022/09
Publisher: 日本緑内障学会
Vasoreactivity of optic nerve head, skin, and nailfold to cold provocation in glaucoma patients

西村尭幸, 高橋成奈, 清田直樹, 山崎舞, 山崎舞, 國方彦志, 津田智博, 青柳寿枝, 蔀美和子, 大塚利彦, 冨田高弘, 中澤徹

日本緑内障学会抄録集　33回　84-84　2022/09
Publisher: 日本緑内障学会
Prediction of Mean devication from fundus photographs using deep learning

二宮高洋, 檜森紀子, 檜森紀子, PARMANAND Sharma, 面高宗子, 遠藤大樹, 三浦幹太, 近野翼, 伊藤康一, 青木孝文, 中澤徹

日本緑内障学会抄録集　33回　85-85　2022/09
Publisher: 日本緑内障学会
Comparison of lamina cribrosa structures observed by SS-OCT in normal and glaucomatous eyes

榎本暢子, 齋藤瞳, 神林洸希, 新家眞, 三木篤也, 富田剛司, 中澤徹, 大野京子, 岩瀬愛子, 東出朋巳, 相原一

日本緑内障学会抄録集　33回　86-86　2022/09
Publisher: 日本緑内障学会
Predictors of visual acuity after trabeculectomy in combination with cataract surgery in glaucoma

武田瑶子, 高橋直樹, 國分太貴, 山口知暁, 津田聡, 面高宗子, 中澤徹

日本緑内障学会抄録集　33回　87-87　2022/09
Publisher: 日本緑内障学会
Automatic eyelid removal program for automatic analysis of filtered bleb scarring with PS-OCT

津田聡, 津田聡, 國分太貴, 佐藤正隆, 清田直樹, 横山悠, 山成正宏, 岡本道明, 中澤徹

日本緑内障学会抄録集　33回　87-87　2022/09
Publisher: 日本緑内障学会
Examination of equol production and glaucoma

内田惠子, 檜森紀子, 檜森紀子, 永井雅, 二宮高洋, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 佐藤孝太, 中澤徹

日本緑内障学会抄録集　33回　90-90　2022/09
Publisher: 日本緑内障学会
The risk factors for intrachoroidal cavitation

山口知暁, 中澤徹, 面高宗子, 津田聡, 高橋直樹, 清田直樹, 武田遥子

日本緑内障学会抄録集　33回　91-91　2022/09
Publisher: 日本緑内障学会
Blood pressure and pulse rate change in response to anti-glaucoma eyedrops

清田直樹, 志賀由己浩, 二宮高洋, 宮武博, 津田聡, 面高宗子, 檜森紀子, 横山悠, 中澤徹

日本緑内障学会抄録集　33回　93-93　2022/09
Publisher: 日本緑内障学会
Factors associated with visual acuity in glaucoma eyes with a thinned papillomacular bundle

高橋直樹, 面高宗子, 木川勉, 武田瑶子, 山口知暁, 清田直樹, 津田聡, 中澤徹

日本緑内障学会抄録集　33回　142-142　2022/09
Publisher: 日本緑内障学会
Examination of the axial length in patients with angle closure with plateau iris

佐久間大輔, 矢花武史, 佐藤正隆, 清田直樹, 津田聡, 横山悠, 中澤徹

日本緑内障学会抄録集　33回　142-142　2022/09
Publisher: 日本緑内障学会
KIRITSU MEIJIN-derived autonomic nervous function and glaucomatous visual-field defect

山田百合菜, 清田直樹, 吉田光秀, 大木広美, 面高宗子, 國方彦志, 中澤徹

日本緑内障学会抄録集　33回　145-145　2022/09
Publisher: 日本緑内障学会
Investigation of neuroprotective mechanisms using a NMDA-receptor permeable probe

石川誠, 佐藤大夢, 大石路子, 神位りえ子, 佐藤孝太, 中澤徹

日本緑内障学会抄録集　33回　180-180　2022/09
Publisher: 日本緑内障学会
緑内障早期治療の知と実践

中澤徹

日本の眼科　93　(9)　1282-1283　2022/09
Publisher: (公社)日本眼科医会
ISSN： 0285-1326
AIが拓く医療の近未来緑内障診療におけるIoT・AI解析の活用

中澤徹

日本歯周病学会会誌　64　(秋季特別)　68-68　2022/08
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
カニクイザルを用いたHMRG硝子体内投与時の蛍光励起波長光による網膜光毒性試験

稲岡志織, 荒木智陽, 坂田恵美, 樺山浩二, 友廣雅之, 國井峻, 鈴木悠記, 津田聡, 中澤徹

比較眼科学会年次大会講演要旨集　41回　35-35　2022/07
Publisher: 比較眼科学会
再発後早期にeculizumabを導入した抗アクアポリン4抗体陽性視神経脊髄炎の2例

金子仁彦, 浪岡靖弘, 大山綾音, 高井良樹, 檜森紀子, 中澤徹, 三須建郎, 青木正志

神経治療学　39　(4)　731-735　2022/07
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
カニクイザルを用いたHMRG硝子体内投与時の蛍光励起波長光による網膜光毒性試験

稲岡志織, 荒木智陽, 坂田恵美, 樺山浩二, 友廣雅之, 國井峻, 鈴木悠記, 津田聡, 中澤徹

比較眼科学会年次大会講演要旨集　41回　35-35　2022/07
Publisher: 比較眼科学会
Glaucoma and chronic inflammation

佐藤大夢, 中澤徹

Bio Clinica　11　(1)　56-61　2022/06
Publisher: (株)北隆館
ISSN： 0919-8237
A case of retinal vasoproliferative tumor removed by pars plana vitrectomy

新田文彦, 國方彦志, 古田実, 阿部俊明, 中澤徹

臨床眼科　76　(5)　677-683　2022/05
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
人を惹きつける魅力的なプレゼンをめざそう!

石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児

Retina Medicine　11　(1)　1-8　2022/04
Publisher: (株)先端医学社
ISSN： 2187-2384
Systemic Risk Factors for Primary Open Angle Glaucoma (POAG)

橋本和軌, 中澤徹

あたらしい眼科　39　(4)　395-401　2022/04
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
統合失調症スペクトラム障害における網膜層異常と臨床要因との関連性系統的レビューとメタ解析

小松浩, 小野口豪, Jerotic Stefan, 金原信久, 角藤芳久, 大野高志, 舩越俊一, 矢花武史, 中澤徹, 富田博秋

精神神経学雑誌　124　(4付録)　S-546　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
統合失調症スペクトラム障害における網膜層異常と臨床要因との関連性系統的レビューとメタ解析

小松浩, 小野口豪, Jerotic Stefan, 金原信久, 角藤芳久, 大野高志, 舩越俊一, 矢花武史, 中澤徹, 富田博秋

精神神経学雑誌　124　(4付録)　S-546　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
手術加療を要した原発先天緑内障眼5例の視力経過

吉田清香, 檜森紀子, 藤岡俊亮, 横山悠, 國松志保, 竹下孝之, 野呂充, 中澤徹

眼科臨床紀要　15　(4)　295-295　2022/04
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
人を惹きつける魅力的なプレゼンをめざそう!

石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児

Retina Medicine　11　(1)　1-8　2022/04
Publisher: (株)先端医学社
ISSN： 2187-2384
【ここまで変わった緑内障診療の新常識】原発開放隅角緑内障の全身的な危険因子

橋本和軌, 中澤徹

あたらしい眼科　39　(4)　395-401　2022/04
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
老化研究から切り拓く新展開加齢性変化と緑内障(New development of ophthalmological research focusing on aging Age-related change and glaucoma)

中澤徹

日本眼科学会雑誌　126　(臨増)　24-24　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Interim report in a prospective study of a 10-point selection method on AP7000

矢花武史, 津田聡, 若梅紗織, 杉山真生, 高津育美, 島田賢, 横山悠, 中澤徹

日本眼科学会雑誌　126　(臨増)　172-172　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Results of color visual field test for glaucoma eyes

佐藤裕之, 佐藤裕之, 國方彦志, 田中芳樹, 面高宗子, 檜森紀子, 市川一夫, 中澤徹

日本眼科学会雑誌　126　(臨増)　172-172　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Safety and efficacy of omidenepag Isopropyl switching monotherapy

中澤徹, 高橋寛二, 桑山泰明, 保木理恵, 島田史規

日本眼科学会雑誌　126　(臨増)　176-176　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
The Impact of Artificial Intelligence on Glaucoma Determination by Physicians

柏木賢治, 豊浦正広, 茅暁陽, 川瀬和秀, 川瀬和秀, 谷戸正樹, 中澤徹, 三木篤也, 森和彦, 森和彦, 吉冨健志

日本眼科学会雑誌　126　(臨増)　177-177　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
AI解析を用いた黄斑部アンギオグラフィーの各種パラメータによる緑内障評価

二宮高洋, 面高宗子, Sharma Parmanand, 橋本和軌, 宮武博, 中澤徹

日本眼科学会雑誌　126　(臨増)　178-178　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Comparison of glaucoma severity determination ability between doctors and AI

福田佳子, 柏木賢治, 豊浦正広, 茅暁陽, 村尾晃平, 佐藤真一, 二宮洋一郎, 川瀬和秀, 川瀬和秀, 谷戸正樹, 中澤徹, 三木篤也, 森和彦, 森和彦, 吉冨健志

日本眼科学会雑誌　126　(臨増)　178-178　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
滲出型加齢黄斑変性に対するブロルシズマブ投与前後の眼血流評価

瀧澤廣輝, 安田正幸, 國方彦志, 王英紀, 星佳佑, 岡部達, 新田文彦, 阿部俊明, 中澤徹

日本眼科学会雑誌　126　(臨増)　187-187　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Relation of nailfold capillary with macular OCTA in abnormal glucose metabolism

岡部達, 安田正幸, 國方彦志, 高田菜生子, 瀧澤廣輝, 前川重人, 前田雄大, 中野譲, 武野團, 中澤徹

日本眼科学会雑誌　126　(臨増)　208-208　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Effect of laser fiber shape on micropulse wave transscleral photocoagulation

津田聡, 國分太貴, 桐山卓也, 岡部達, 山成正宏, 岡本道明, 中澤徹

日本眼科学会雑誌　126　(臨増)　242-242　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜興奮毒性に対する小胞体ストレス抑制と抗炎症の相乗的な神経保護治療

佐藤孝太, 佐藤大夢, 大石路子, 中澤徹

日本眼科学会雑誌　126　(臨増)　251-251　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Allopregnanolone enantiomer prevents pressure-mediated retinal degeneration

石川誠, 佐藤大夢, 佐藤孝太, 國方彦志, 吉冨健志, 中澤徹

日本眼科学会雑誌　126　(臨増)　252-252　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Association between PMB and postoperative visual loss after Trab in glaucoma

武田瑶子, 高橋直樹, 國分太貴, 津田聡, 面高宗子, 中澤徹

日本眼科学会雑誌　126　(臨増)　253-253　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障眼におけるSS-OCT黄斑セクターに着目した視力との関連

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本眼科学会雑誌　126　(臨増)　253-253　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
正常眼および緑内障眼におけるprelaminar schisisの頻度とその関連因子

齋藤瞳, 神林洸希, 新家眞, 三木篤也, 富田剛司, 中澤徹, 大野京子, 岩瀬愛子, 東出朋巳, 杉山和久, 相原一

日本眼科学会雑誌　126　(臨増)　254-254　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
En-face画像によるIntrachoroidal cavitationの解析

山口知暁, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　126　(臨増)　268-268　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
The gender risk factor of sleep apnea syndrome in normal tension glaucoma

山崎舞, 山崎舞, 檜森紀子, 檜森紀子, 矢花武史, 國分太貴, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　126　(臨増)　271-271　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障病型における脈波と自律神経パラメータとの関連性について

前川重人, 面高宗子, 吉澤誠, 中澤徹

日本眼科学会雑誌　126　(臨増)　272-272　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
近視性脈絡膜新生血管と全身酸化ストレスマーカーの関連

王紀英, 安田正幸, 國方彦志, 岡部達, 星佳佑, 滝澤廣輝, 中澤徹

日本眼科学会雑誌　126　(臨増)　280-280　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
2D-MEMS scannerを用いた、スマート眼鏡の開発

松本拓朗, Kaushik Neelam, 瀧澤廣輝, 佐藤正隆, 二宮高洋, 矢花武史, 檜森紀子, 羽根一博, 中澤徹

日本眼科学会雑誌　126　(臨増)　307-307　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
老化研究から切り拓く新展開加齢性変化と緑内障(New development of ophthalmological research focusing on aging Age-related change and glaucoma)

中澤徹

日本眼科学会雑誌　126　(臨増)　24-24　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Interim report in a prospective study of a 10-point selection method on AP7000

矢花武史, 津田聡, 若梅紗織, 杉山真生, 高津育美, 島田賢, 横山悠, 中澤徹

日本眼科学会雑誌　126　(臨増)　172-172　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Results of color visual field test for glaucoma eyes

佐藤裕之, 佐藤裕之, 國方彦志, 田中芳樹, 面高宗子, 檜森紀子, 市川一夫, 中澤徹

日本眼科学会雑誌　126　(臨増)　172-172　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
オミデネパグイソプロピル切替単剤療法の安全性と有効性(多施設観察研究中間報告)

中澤徹, 高橋寛二, 桑山泰明, 保木理恵, 島田史規

日本眼科学会雑誌　126　(臨増)　176-176　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Evaluation of glaucoma using AI processed macular OCT angiography parameters

二宮高洋, 面高宗子, SHARMA Parmanand, 橋本和軌, 宮武博, 中澤徹

日本眼科学会雑誌　126　(臨増)　178-178　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Evaluation of ocular blood flow after intravitreal injection of Brolucizumab

瀧澤廣輝, 安田正幸, 國方彦志, 王英紀, 星佳佑, 岡部達, 新田文彦, 阿部俊明, 中澤徹

日本眼科学会雑誌　126　(臨増)　187-187　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Relation of nailfold capillary with macular OCTA in abnormal glucose metabolism

岡部達, 安田正幸, 國方彦志, 高田菜生子, 瀧澤廣輝, 前川重人, 前田雄大, 中野譲, 武野團, 中澤徹

日本眼科学会雑誌　126　(臨増)　208-208　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Effect of laser fiber shape on micropulse wave transscleral photocoagulation

津田聡, 國分太貴, 桐山卓也, 岡部達, 山成正宏, 岡本道明, 中澤徹

日本眼科学会雑誌　126　(臨増)　242-242　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Synergistic neuroprotection by ER stress suppression and anti-inflammatory

佐藤孝太, 佐藤大夢, 大石路子, 中澤徹

日本眼科学会雑誌　126　(臨増)　251-251　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Allopregnanolone enantiomer prevents pressure-mediated retinal degeneration

石川誠, 佐藤大夢, 佐藤孝太, 國方彦志, 吉冨健志, 中澤徹

日本眼科学会雑誌　126　(臨増)　252-252　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
乳頭黄斑線維束に着目した緑内障における線維柱帯切除術後の視力低下

武田瑶子, 高橋直樹, 國分太貴, 津田聡, 面高宗子, 中澤徹

日本眼科学会雑誌　126　(臨増)　253-253　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Association between visual acuity and SS-OCT macular sector in glaucoma

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本眼科学会雑誌　126　(臨増)　253-253　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Frequency and associated factors of prelaminar schisis

齋藤瞳, 神林洸希, 新家眞, 三木篤也, 富田剛司, 中澤徹, 大野京子, 岩瀬愛子, 東出朋巳, 杉山和久, 相原一

日本眼科学会雑誌　126　(臨増)　254-254　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
En-face画像によるIntrachoroidal cavitationの解析

山口知暁, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　126　(臨増)　268-268　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
正常眼圧緑内障患者における睡眠時無呼吸症候群の男女別リスク因子の検討

山崎舞, 檜森紀子, 矢花武史, 國分太貴, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　126　(臨増)　271-271　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Relationship between pulse waves and autonomic nerve parameters in POAG and NTG

前川重人, 面高宗子, 吉澤誠, 中澤徹

日本眼科学会雑誌　126　(臨増)　272-272　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Detection of serial changes in the brain associated with glaucoma using MRI.

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　126　(臨増)　272-272　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
The potential role of oxidative stress in myopic CNV

王紀英, 安田正幸, 國方彦志, 岡部達, 星佳佑, 滝澤廣輝, 中澤徹

日本眼科学会雑誌　126　(臨増)　280-280　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
MEMS-based wearable eyeglasses for eye health monitoring.

松本拓朗, KAUSHIK Neelam, 瀧澤廣輝, 佐藤正隆, 二宮高洋, 矢花武史, 檜森紀子, 檜森紀子, 羽根一博, 中澤徹

日本眼科学会雑誌　126　(臨増)　307-307　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
【眼科医のための薬理学のイロハ】バイオマーカー探索と眼科への応用

高田菜生子, 中澤徹

OCULISTA　(107)　66-72　2022/02
Publisher: (株)全日本病院出版会
ISSN： 2187-5855
A case of recurrent epithelial herpetic keratitis with band keratopathy.

小犬丸直弘, 小林航, 吉田真彰, 針谷威寛, 横倉俊二, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　46th-38th　2022
Usefulness of Multiplex PCR for Diagnosis of Herpetic Keratitis

針谷威寛, 小林航, 小犬丸直弘, 吉田真彰, 横倉俊二, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　46th-38th　2022
Relationship between ophthalmologic parameters and hippocampal volume

山田晃生, 舘脇康子, 面高宗子, 松平泉, BENJAMIN Thyreau, 瀧靖之, 中澤徹

日本緑内障学会抄録集　33rd　2022
CADi2-derived cognitive function and glaucomatous visual-field defect

佐藤正隆, 山田晃生, 清田直樹, 津田聡, 大木広美, 吉田光秀, 冨田尚希, 國方彦志, 瀧靖之, 中澤徹

日本緑内障学会抄録集　33rd　2022
Relationship between keratoconus and cpRNFLT

小林航, 横倉俊二, 小犬丸直弘, 吉田真彰, 針谷威寛, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　46th-38th　2022
Biomarker discovery for glaucoma using human aquas humor by UHPLC-FTMS

小暮瑞穂, 佐藤孝太, 藤岡周, 國分太貴, 吉田真彰, 横山悠, 福内友子, 山岡法子, 中澤徹, 三枝大輔, 三枝大輔

質量分析総合討論会講演要旨集　70th　2022
Investigation of Intrachoroidal cavitation with SS-OCT

山口知暁, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　126　2022

ISSN： 0029-0203
サイトメガロウイルス陽性続発緑内障のトラベクレクトミー術後成績

吉田真彰, 横山悠, 國分太貴, 津田聡, 檜森紀子, 前川重人, 針谷威寛, 橋本和軌, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　58th-55th-64th-10th　2022
眼底3次元画像からの中心窩検出と緑内障診断支援への応用

近野翼, 二宮高洋, 三浦幹太, 伊藤康一, 檜森紀子, PARMANAND Sharma, 中澤徹, 青木孝文

映像情報メディア学会技術報告　46　(26(ME2022 72-82))　2022

ISSN： 1342-6893
眼底3次元画像解析のための画像セグメンテーションに関する検討

近野翼, 二宮高洋, 三浦幹太, 伊藤康一, 檜森紀子, PARMANAND Sharma, 中澤徹, 青木孝文

電気関係学会東北支部連合大会講演論文集(CD-ROM)　2022　2022
緑内障診療におけるIoT・AI解析の活用

中澤徹

日本歯周病学会会誌(Web)　64　2022

ISSN： 1880-408X
緑内障に関するAI研究

中澤徹

日本眼光学学会総会プログラム・抄録集　58th　2022
Cases of anti-aquaporin4 antibody-positive neuromyelitis optica spectrum disorder treated with eculizumab initiated immediately after acute treatment

金子仁彦, 浪岡靖弘, 大山綾音, 高井良樹, 檜森紀子, 中澤徹, 三須建郎, 青木正志

神経治療学(Web)　39　(4)　2022

ISSN： 2189-7824
爪床毛細血管パラメータと非糖尿病網膜症の関係

岡部達, 安田正幸, 國方彦志, 高田菜生子, 前田雄大, 中野讓, 武野團, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　61st　(10)　733-733　2022
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Retinal Artery Occlusion

津田聡, 中澤徹

あたらしい眼科　39　(1)　31-37　2022/01
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
Matabolomic analysis of diabetic retinopathy

安田正幸, 國方彦志, 児玉慎二郎, 岡部達, 菱沼英史, 菱沼英史, 瀧澤廣輝, 片桐秀樹, 小柴生造, 小柴生造, 中澤徹, 中澤徹

日本眼科学会雑誌　126　2022

ISSN： 0029-0203
Newly Developed ”Smart Glasses” for Simulating Visual Field Defects-Accuracy of Reproduction and Usefulness of the Device-

高津育美, 鈴鴨よしみ, 平林春花, 谷口広明, 青柳祐也, 中澤徹

日本ロービジョン学会誌　21　44-50　2021/12
Publisher: 日本眼科紀要会
ISSN： 2436-7850
Diabetic papillopathy and the OCT findings

小杉真代, 竹下孝之, 高宮美智子, 中澤徹

眼科臨床紀要　14　(12)　832-837　2021/12
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
外傷性黄斑円孔に対する硝子体手術成績

長田麗, 國方彦志, 新田文彦, 阿部俊明, 中澤徹

眼科臨床紀要　14　(11)　754-754　2021/11
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
深層学習を用いた術前眼底写真からの黄斑円孔術後視力予測

二宮高洋, 國方彦志, 阿部俊明, 中澤徹

眼科臨床紀要　14　(11)　756-756　2021/11
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Bilateral diffuse uveal melanocytic proliferationの1例

新田文彦, 西口康二, 國方彦志, 中澤徹

眼科臨床紀要　14　(11)　771-772　2021/11
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
診療AI開発基盤となる地域医療データの収集システムの構築とAI診療の可能性の検証

横山悠, 竹田徳泰, 藤井進, 中村直毅, 井戸敬介, 桐山卓也, 大槻昌人, 木川勉, 荻島創一, 中山雅晴, 中澤徹

医療情報学連合大会論文集　41回　531-534　2021/11
Publisher: (一社)日本医療情報学会
ISSN： 1347-8508

eISSN： 2433-698X
失明原因第一位の緑内障における治療開発課題

中澤徹

薬剤疫学　26　(Suppl.)　S49-S49　2021/11
Publisher: (一社)日本薬剤疫学会
DOI： 10.3820/jjpe.26.s49 　

ISSN： 1342-0445

eISSN： 1882-790X
糖尿病における体成分組成と眼血流の関連

安田正幸, 國方彦志, 伊藤梓, 岡部達, 黒澤聡子, 土屋暁子, 澤田正二郎, 片桐秀樹, 中澤徹

眼科臨床紀要　14　(10)　692-692　2021/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
LSS欠損症における組織特異的モデルマウスを用いた代謝および病理プロファイル

和田陽一, 菊池敦生, 加賀元宗, 清水直紀, 伊藤隼哉, 新堀哲也, 佐藤孝太, 中澤徹, 中山啓子, 青木洋子, 仲川清隆, 呉繁夫

日本先天代謝異常学会雑誌　37　126-126　2021/09
Publisher: (一社)日本先天代謝異常学会
ISSN： 0912-0122
緑内障関連遺伝子研究班の活動報告

中澤徹

日本緑内障学会抄録集　32回　47-47　2021/09
Publisher: 日本緑内障学会
ヒトiPS細胞由来3次元立体網膜組織に対する静水圧負荷の検討

小林航, 吉野大輔, 継田美里, 堺香名子, 小椋利彦, 中澤徹

日本緑内障学会抄録集　32回　77-77　2021/09
Publisher: 日本緑内障学会
正常眼圧緑内障患者における酸化ストレスマーカーと視神経乳頭血流の関連

佐藤正隆, 安田正幸, 高橋成奈, 橋本和軌, 檜森紀子, 中澤徹

日本緑内障学会抄録集　32回　80-80　2021/09
Publisher: 日本緑内障学会
正常眼圧緑内障における血中エンドセリン濃度とFlammer症候群および視野進行の関連

高橋成奈, 佐藤孝太, 高田菜生子, 志賀由己浩, 清田直樹, 安田正幸, 津田聡, 面高宗子, 中澤徹

日本緑内障学会抄録集　32回　80-80　2021/09
Publisher: 日本緑内障学会
非カフ型腕時計血流動態センサーによる全身循環日内変動と緑内障との関連

前川重人, 矢花武史, 檜森紀子, 面高宗子, 佐藤晶彦, 早瀬敏幸, 中澤徹

日本緑内障学会抄録集　32回　81-81　2021/09
Publisher: 日本緑内障学会
簡易ドライビングシミュレータによるSOM解析を用いた自動車事故に関与する視野障害部位の検討

國松志保, 高橋政代, 岩瀬愛子, 中澤徹, 福地健郎

日本緑内障学会抄録集　32回　83-83　2021/09
Publisher: 日本緑内障学会
メタボローム解析による視神経障害バイオマーカーの探索

佐藤孝太, 三枝大輔, 藤岡周, 中澤徹

日本緑内障学会抄録集　32回　89-89　2021/09
Publisher: 日本緑内障学会
マイクロパルス波経強膜光凝固術の新型プローブ(Rev2)の照射条件の検討

津田聡, 國分太貴, 桐山卓也, 岡部達, 山成正宏, 岡本道明, 中澤徹

日本緑内障学会抄録集　32回　131-131　2021/09
Publisher: 日本緑内障学会
ヘッドマウント型視野計アイモでの視野検査における瞳孔径変化

佐藤大夢, 面高宗子, 前川重人, 杉山真生, 木幡未央, 矢花武史, 中澤徹

日本緑内障学会抄録集　32回　135-135　2021/09
Publisher: 日本緑内障学会
緑内障眼における構造障害進行と視野障害進行の関連

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本緑内障学会抄録集　32回　142-142　2021/09
Publisher: 日本緑内障学会
緑内障患者における緑内障危険因子の分布

蒲倉紗也佳, 面高宗子, 杉山真生, 高津育美, 二宮高洋, 中澤徹

日本緑内障学会抄録集　32回　146-146　2021/09
Publisher: 日本緑内障学会
Clinical characteristics of each glaucoma risk factor in glaucoma patients

面高宗子, 木川勉, AN Guangzhou, 二宮高洋, 蒲倉紗也佳, 杉山真生, 高津育美, 宮武博, 秋葉正博, 中澤徹

日本緑内障学会抄録集　32回　146-146　2021/09
Publisher: 日本緑内障学会
正常眼圧緑内障患者における睡眠時無呼吸症候群の有病率とリスク因子の検討

山崎舞, 檜森紀子, 矢花武史, 國分太貴, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本緑内障学会抄録集　32回　147-147　2021/09
Publisher: 日本緑内障学会
当院におけるマイクロフックロトミー後の前房出血に対する前房洗浄の短期予後

矢花武史, 國分太貴, 前川重人, 津田聡, 横山悠, 中澤徹

日本緑内障学会抄録集　32回　166-166　2021/09
Publisher: 日本緑内障学会
Examination of the usefulness of Al-based FAZ measurement in glaucoma

二宮高洋, 面高宗子, PARMANAD Sharma, 橋本和軌, 宮武博, 中澤徹

日本緑内障学会抄録集　32回　171-171　2021/09
Publisher: 日本緑内障学会
ラット緑内障モデルにおける神経ステロイドの相加的神経保護

石川誠, 佐藤大夢, 佐藤孝太, 吉冨健志, 中澤徹

日本緑内障学会抄録集　32回　176-176　2021/09
Publisher: 日本緑内障学会
Reproducibility of macular vascular density (MVD) and relationship between MVD and glaucoma damage

加藤千穂, 面高宗子, 堀江寿雲, 東海林ひかり, 福岡世理, 大内順子, 中澤徹

日本緑内障学会抄録集　32回　179-179　2021/09
Publisher: 日本緑内障学会
正常眼における視野感度とSS-OCTを用いた視神経乳頭構造の解析(Swept-source OCT derived optic nerve head structures and visual field sensitivity in normal eyes)

神林洸希, 新家眞, 村田博史, 木川勉, 三木篤也, 富田剛司, 中澤徹, 大野京子, 岩瀬愛子, 相原一, 近視・緑内障SS-OCT研究グループ

日本緑内障学会抄録集　32回　179-179　2021/09
Publisher: 日本緑内障学会
SS-OCTで観察した正常な眼における眼軸長の伸長に関連した視神経頭構造の変化(SS-OCT derived optic nerve head structures associated with axial length elongation in normal eyes)

齋藤瞳, 新家眞, 村田博史, 木川勉, 三木篤也, 富田剛司, 中澤徹, 大野京子, 岩瀬愛子, 相原一, 近視・緑内障SS-OCT研究グループ

日本緑内障学会抄録集　32回　189-189　2021/09
Publisher: 日本緑内障学会
深層学習を用いた術前眼底写真からの黄斑前膜術後視力予測

國方彦志, 二宮高洋, 阿部俊明, 中澤徹

眼科臨床紀要　14　(9)　612-613　2021/09
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
LSS欠損症における組織特異的モデルマウスを用いた代謝および病理プロファイル

和田陽一, 菊池敦生, 加賀元宗, 清水直紀, 伊藤隼哉, 新堀哲也, 佐藤孝太, 中澤徹, 中山啓子, 青木洋子, 仲川清隆, 呉繁夫

日本先天代謝異常学会雑誌　37　126-126　2021/09
Publisher: (一社)日本先天代謝異常学会
ISSN： 0912-0122
Annual report from Japanese Glaucoma Society Omics Group (JGS-OG)

中澤徹

日本緑内障学会抄録集　32回　47-47　2021/09
Publisher: 日本緑内障学会
Investigation of hydrostatic pressure loading on retinal organoids derived from human iPSCs

小林航, 吉野大輔, 継田美里, 堺香名子, 小椋利彦, 中澤徹

日本緑内障学会抄録集　32回　77-77　2021/09
Publisher: 日本緑内障学会
Association between oxidative stress and optic nerve head blood flow in normal tension glaucoma

佐藤正隆, 安田正幸, 高橋成奈, 橋本和軌, 檜森紀子, 中澤徹

日本緑内障学会抄録集　32回　80-80　2021/09
Publisher: 日本緑内障学会
Association between endothelin-1 and visual field in normal tension glaucoma with Flammer Syndrome

高橋成奈, 佐藤孝太, 高田菜生子, 志賀由己浩, 清田直樹, 安田正幸, 津田聡, 面高宗子, 中澤徹

日本緑内障学会抄録集　32回　80-80　2021/09
Publisher: 日本緑内障学会
Relationship between systemic circulatory diurnal variation and glaucoma by hemodynamic sensor

前川重人, 矢花武史, 檜森紀子, 面高宗子, 佐藤晶彦, 早瀬敏幸, 中澤徹

日本緑内障学会抄録集　32回　81-81　2021/09
Publisher: 日本緑内障学会
Evaluation of the specific visual subfields in motor vehicle collisions during simulated driving

國松志保, 國松志保, 高橋政代, 高橋政代, 岩瀬愛子, 中澤徹, 福地健郎

日本緑内障学会抄録集　32回　83-83　2021/09
Publisher: 日本緑内障学会
Investigation for biomarkers on optic nerve damage by metabolomic analysis

佐藤孝太, 三枝大輔, 藤岡周, 中澤徹

日本緑内障学会抄録集　32回　89-89　2021/09
Publisher: 日本緑内障学会
Irradiation conditions of the new probe (Rev2) for micropulse wave transscleral photocoagulation

津田聡, 國分太貴, 桐山卓也, 岡部達, 山成正宏, 岡本道明, 中澤徹

日本緑内障学会抄録集　32回　131-131　2021/09
Publisher: 日本緑内障学会
Changes in pupil diameter during visual field test of imo

佐藤大夢, 面高宗子, 前川重人, 杉山真生, 木幡未央, 矢花武史, 中澤徹

日本緑内障学会抄録集　32回　135-135　2021/09
Publisher: 日本緑内障学会
Association between OCT and visual field progression in glaucoma patients

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本緑内障学会抄録集　32回　142-142　2021/09
Publisher: 日本緑内障学会
Distribution of Glaucoma Risk Factors in Glaucoma Patients

蒲倉紗也佳, 面高宗子, 杉山真生, 高津育美, 二宮高洋, 中澤徹

日本緑内障学会抄録集　32回　146-146　2021/09
Publisher: 日本緑内障学会
緑内障患者における緑内障危険因子ごとの臨床的特徴

面高宗子, 木川勉, 安光州, 二宮高洋, 蒲倉紗也佳, 杉山真生, 高津育美, 宮武博, 秋葉正博, 中澤徹

日本緑内障学会抄録集　32回　146-146　2021/09
Publisher: 日本緑内障学会
The prevalence and risk factors of sleep apnea syndrome in patients with normal tension glaucoma

山崎舞, 山崎舞, 檜森紀子, 矢花武史, 國分太貴, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本緑内障学会抄録集　32回　147-147　2021/09
Publisher: 日本緑内障学会
Short-term outcome of anterior chamber irrigation for hemorrhage after Micro-hook trabeculotomy

矢花武史, 國分太貴, 前川重人, 津田聡, 横山悠, 中澤徹

日本緑内障学会抄録集　32回　166-166　2021/09
Publisher: 日本緑内障学会
緑内障におけるAIによるFAZ計測の有用性の検討

二宮高洋, 面高宗子, Parmanad Sharma, 橋本和軌, 宮武博, 中澤徹

日本緑内障学会抄録集　32回　171-171　2021/09
Publisher: 日本緑内障学会
Additive neuroprotection by neurosteroids in an ex vivo rat glaucoma model

石川誠, 佐藤大夢, 佐藤孝太, 吉冨健志, 中澤徹

日本緑内障学会抄録集　32回　176-176　2021/09
Publisher: 日本緑内障学会
OCTA黄斑部血管密度の再現性と緑内障性障害との相関

加藤千穂, 面高宗子, 堀江寿雲, 東海林ひかり, 福岡世理, 大内順子, 中澤徹

日本緑内障学会抄録集　32回　179-179　2021/09
Publisher: 日本緑内障学会
正常眼における視野感度とSS-OCTを用いた視神経乳頭構造の解析(Swept-source OCT derived optic nerve head structures and visual field sensitivity in normal eyes)

神林洸希, 新家眞, 村田博史, 木川勉, 三木篤也, 富田剛司, 中澤徹, 大野京子, 岩瀬愛子, 相原一, 近視・緑内障SS-OCT研究グループ

日本緑内障学会抄録集　32回　179-179　2021/09
Publisher: 日本緑内障学会
SS-OCTで観察した正常な眼における眼軸長の伸長に関連した視神経頭構造の変化(SS-OCT derived optic nerve head structures associated with axial length elongation in normal eyes)

齋藤瞳, 新家眞, 村田博史, 木川勉, 三木篤也, 富田剛司, 中澤徹, 大野京子, 岩瀬愛子, 相原一, 近視・緑内障SS-OCT研究グループ

日本緑内障学会抄録集　32回　189-189　2021/09
Publisher: 日本緑内障学会
A case of delayed-onset endophthalmitis due to intraocular iron foreign body detected by MRI

新田文彦, 國方彦志, 西口康二, 西口康二, 阿部俊明, 中澤徹

臨床眼科　75　(7)　947-952　2021/07
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
若い感覚をキープする:超早期診断・バイオマーカー編緑内障の超早期診断

中澤徹

日本抗加齢医学会総会プログラム・抄録集　21回　143-143　2021/06
Publisher: (一社)日本抗加齢医学会
若い感覚をキープする:超早期診断・バイオマーカー編緑内障の超早期診断

中澤徹

日本抗加齢医学会総会プログラム・抄録集　21回　143-143　2021/06
Publisher: (一社)日本抗加齢医学会
家兎でのマイクロパルス波経強膜毛様体光凝固術後の眼圧下降と組織障害の検討

津田聡, 國分太貴, 岡部達, 桐山卓也, 中澤徹

日本眼科学会雑誌　125　(臨増)　175-175　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
outlier of oxidative stress parameter in normal and glaucoma

前川重人, 檜森紀子, 面高宗子, 中澤徹

日本眼科学会雑誌　125　(臨増)　176-176　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Protective effect for corneal endothelium with normal-tension cataract surgery

國分太貴, 津田聡, 矢花武史, 前川重人, 横山悠, 國方彦志, 中澤徹

日本眼科学会雑誌　125　(臨増)　188-188　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Association of nailfold capillary changes with diabetic retinopathy

岡部達, 安田正幸, 國方彦志, 武野團, 中澤徹

日本眼科学会雑誌　125　(臨増)　197-197　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Time-course Changes in Ocular Blood Flow and Glaucomatous Neurodegeneration

清田直樹, 志賀由己浩, 面高宗子, 朴慶純, 中澤徹

日本眼科学会雑誌　125　(臨増)　216-216　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Examination of macular OCTA parameters in glaucoma patients using AI

二宮高洋, 面高宗子, SHARMA Parmanand, 橋本和軌, 宮武博, 中澤徹

日本眼科学会雑誌　125　(臨増)　217-217　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Association between Flammer Syndrome and blood flow in normal tension glaucoma

高橋成奈, 志賀由己浩, 清田直樹, 安田正幸, 面高宗子, 檜森紀子, 中澤徹

日本眼科学会雑誌　125　(臨増)　217-217　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Diagnostic power of 24plus (1) on the head-mounted perimeter imo

佐藤大夢, 面高宗子, 前川重人, 杉山真生, 新妻未央, 近藤美千子, 矢花武史, 中澤徹

日本眼科学会雑誌　125　(臨増)　218-218　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Investigation of RNFLB associated with visual acuity by SS-OCT

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本眼科学会雑誌　125　(臨増)　219-219　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
正常眼圧緑内障の病期とcorneal hysteresisの関連

内田惠子, 檜森紀子, 國分太貴, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　125　(臨増)　240-240　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Development of an AI chatBOT for glaucoma

矢花武史, 二宮高洋, 前川重人, 檜森紀子, 面高宗子, 中澤徹

日本眼科学会雑誌　125　(臨増)　240-240　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Examination of the frequency of occurrence of DH in glaucoma patients by AI

面高宗子, 安光州, 安光州, 二宮高洋, 木川勉, 橋本和軌, 宮武博, 横田秀夫, 秋葉正博, 中澤徹

日本眼科学会雑誌　125　(臨増)　240-240　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Calculation of pulse waves and autonomic nervous using videoplethysmography

佐々木栞菜, 前川重人, 面高宗子, 近藤美千子, 吉澤誠, 中澤徹

日本眼科学会雑誌　125　(臨増)　249-249　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
IOP reduction and tissue damage after micropulse wave TSCPC in rabbits

津田聡, 國分太貴, 岡部達, 桐山卓也, 中澤徹

日本眼科学会雑誌　125　(臨増)　175-175　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
正常眼圧白内障手術の角膜内皮保護効果に関する検証

國分太貴, 津田聡, 矢花武史, 前川重人, 横山悠, 國方彦志, 中澤徹

日本眼科学会雑誌　125　(臨増)　188-188　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
The association between cornel hysteresis and stage of normal tension glaucoma

内田惠子, 檜森紀子, 國分太貴, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　125　(臨増)　240-240　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
眼科疾患に対する創薬・再生医療研究モデル動物を用いた網膜神経節細胞死の病態解明と創薬研究

佐藤孝太, 中澤徹

日本眼薬理学会プログラム・抄録集　40回　30-30　2021/02
Publisher: 日本眼薬理学会
眼科疾患に対する創薬・再生医療研究モデル動物を用いた網膜神経節細胞死の病態解明と創薬研究

佐藤孝太, 中澤徹

日本眼薬理学会プログラム・抄録集　40回　30-30　2021/02
Publisher: 日本眼薬理学会
コロナで眼科はどう変わったか?

近藤峰生, 井上真, 加藤圭一, 中澤徹, 野田実香, 堀裕一

眼科グラフィック　10　(1)　4-9　2021/02
Publisher: (株)メディカ出版
ISSN： 2187-2422
Regulations and Case Study of Real World Data for Regulatory Decision-making in Japan and the US

石井学, 石井学, 阪本亘, 阪本亘, 東郷香苗, 東郷香苗, 中澤徹, 中澤徹, 島崎聡立, 島崎聡立, 田中真衣, 田中真衣, 大手辰哉, 大手辰哉, 松澤寛, 松澤寛

レギュラトリーサイエンス学会誌　11　(1)　2021

ISSN： 2185-7113
Clinical trial for LSCD using cultivated limbal epithelial cell sheets

大家義則, 杉田征一郎, 島崎潤, 中澤徹, 白石敦, 小笠原隆広, 井家益和, 西田幸二

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　45th-37th　2021
Characteristics of cases positive for cytomegalovirus by Multiplex PCR

針谷威寛, 横倉俊二, 吉田真彰, 小林航, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　45th-37th　2021
Relationship between keratoconus and circumpapillary RNFLT

小林航, 横倉俊二, 吉田真彰, 針谷威寛, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　45th-37th　2021
角膜上皮幹細胞疲弊症に対する自己培養角膜上皮細胞シート移植の多施設共同治験

大家義則, 杉田征一郎, 島崎潤, 中澤徹, 白石敦, 小笠原隆広, 井家益和, 西田幸二

日本再生医療学会総会(Web)　20th　2021
Construction of system to collect regional medical data that will serve as a foundation for the development of AI in medical care, and verification of the possibility of the AI remote diagnosis

横山悠, 竹田徳泰, 藤井進, 藤井進, 中村直毅, 井戸敬介, 桐山卓也, 大槻昌人, 木川勉, 荻島創一, 中山雅晴, 中山雅晴, 中山雅晴, 中澤徹

医療情報学連合大会論文集(CD-ROM)　41st　2021

ISSN： 2433-698X
LSS欠損症における組織特異的モデルマウスを用いた代謝および病理プロファイル

和田陽一, 菊池敦生, 加賀元宗, 清水直紀, 伊藤隼哉, 新堀哲也, 佐藤孝太, 中澤徹, 中山啓子, 青木洋子, 仲川清隆, 呉繁夫

日本先天代謝異常学会雑誌　37　2021

ISSN： 0912-0122
Rho-kinase involvement on microglial activation of mice retina by nerve crush

佐藤孝太, 大石路子, 吉田真彰, 前川重人, 中澤徹

日本眼科学会雑誌　125　(臨増)　174-174　2021
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
眼からみる老化脳 HSIカメラによる軽度認知障害(MCI)の未病診断へ向けて

森望, 中澤徹

未病と抗老化　29　24-29　2020/11
Publisher: (一財)博慈会老人病研究所
ISSN： 1347-667X
Metabolic changes and retinal ganglion cell death

佐藤孝太, 中澤徹

日本緑内障学会抄録集　31回　61-61　2020/10
Publisher: 日本緑内障学会
Changes of neuroprotective factors in mouse Muller cells after mitochondrial Complex I inhibition

柳町真希, 柳町真希, 檜森紀子, 俵山寛司, 佐藤孝太, 行方和彦, 原田高幸, 山本雅之, 中澤徹

日本緑内障学会抄録集　31回　72-72　2020/10
Publisher: 日本緑内障学会
Neuroprotective effect of Selenoneine in cultured neurons

吉田真彰, 佐藤孝太, 大石路子, 市川惠一, 原精一, 五味恵子, 伊藤考太郎, 中澤徹

日本緑内障学会抄録集　31回　72-72　2020/10
Publisher: 日本緑内障学会
Cytokine expression of activated microglia in mice retina following optic nerve crush mice

佐藤孝太, 横山悠, 檜森紀子, 面高宗子, 前川重人, 中澤徹

日本緑内障学会抄録集　31回　73-73　2020/10
Publisher: 日本緑内障学会
Association between Flammer Syndrome Questionnaire and POAG subtypes

高橋成奈, 志賀由己浩, 清田直樹, 安田正幸, 佐藤茉莉華, 津田聡, 檜森紀子, 面高宗子, 高山真, 石井正, 中澤徹

日本緑内障学会抄録集　31回　75-75　2020/10
Publisher: 日本緑内障学会
Needling postoperative results and anterior segment optical coherence tomography of Bleb structure

小杉真代, 小杉真代, 津田聡, 國分太貴, 矢花武史, 前川重人, 横山悠, 中澤徹

日本緑内障学会抄録集　31回　81-81　2020/10
Publisher: 日本緑内障学会
Reproducibility of heart rate measuring device using video pulse wave extraction technology

三浦直晃, 前川重人, 近藤美千子, 面高宗子, 清水光久, 吉澤誠, 中澤徹

日本緑内障学会抄録集　31回　95-95　2020/10
Publisher: 日本緑内障学会
Relationship between MRI of the primary visual cortex and estimated retinal ganglion cell count.

山田晃生, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　31回　145-145　2020/10
Publisher: 日本緑内障学会
Usefulness of nailfold capillary for the diagnosis of glaucoma

前川重人, 三浦直晃, 近藤美千子, 面高宗子, 待谷貴央, 武野團, 中澤徹

日本緑内障学会抄録集　31回　145-145　2020/10
Publisher: 日本緑内障学会
Evaluation of scleral birefringence by polarization sensitive OCT in glaucomatous eyes

桐山卓也, 津田聡, 國分太貴, 山成正宏, 矢花武史, 前川重人, 横山悠, 中澤徹

日本緑内障学会抄録集　31回　145-145　2020/10
Publisher: 日本緑内障学会
Long-term changes in optic disc parameters with stereo fundus camera in Nicolela’s classification

山田百合菜, 横山悠, 谷戸正樹, 新田耕治, 岩瀬愛子, 溝上志朗, 高井保幸, 面高宗子, 片井麻貴, 北岡康史, 内藤知子, 山下高明, 中澤徹

日本緑内障学会抄録集　31回　146-146　2020/10
Publisher: 日本緑内障学会
Long-term changes in optic disc topography parameters determined by a stereo fundus camera

横山悠, 谷戸正樹, 新田耕治, 岩瀬愛子, 溝上志朗, 高井保幸, 面高宗子, 片井麻貴, 北岡康史, 内藤知子, 山下高明, 中澤徹

日本緑内障学会抄録集　31回　147-147　2020/10
Publisher: 日本緑内障学会
Evaluation of visual field progression by measurement of retinal nerve fiber layer defect angle

高橋直樹, 面高宗子, 中澤新, 木川勉, 中澤徹

日本緑内障学会抄録集　31回　147-147　2020/10
Publisher: 日本緑内障学会
Deep learning predictions of visual field progression with GPA report

二宮高洋, 面高宗子, 橋本和軌, 高田菜生子, 矢花武史, 中澤徹

日本緑内障学会抄録集　31回　164-164　2020/10
Publisher: 日本緑内障学会
Identification of Glaucoma Biomarker by Metabolome Analysis and Its Application for Personalized Medicine

中澤徹

眼薬理　34　(1)　59-63　2020/09
Publisher: 日本眼薬理学会
ISSN： 0914-1405
OCTの技術的進歩と事業化、そして臨床応用の最前線眼科臨床におけるOCTの活用事例

中澤徹

日本医用画像工学会大会予稿集　39回　51-51　2020/09
Publisher: 日本医用画像工学会
ISSN： 0288-450X
緑内障患者における複合サプリメント摂取による酸化ストレス、抗酸化力の変動

檜森紀子, 柳町真希, 志賀由己浩, 面高宗子, 津田聡, 國方彦志, 中澤徹

日本抗加齢医学会総会プログラム・抄録集　20回　191-191　2020/09
Publisher: (一社)日本抗加齢医学会
SAG変異を病因とする小口病と網膜色素変性の臨床表現型比較

西口康二, 池田康博, 細野克博, 和田裕子, 園田康平, 堀田喜裕, 村上晶, 中澤満, 中澤徹, 阿部俊明

眼科臨床紀要　13　(7)　490-490　2020/07
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
【レーザースペックルフローグラフィー】わかりやすい臨床講座緑内障臨床におけるレーザースペックルフローグラフィーの有用性

清田直樹, 中澤徹

日本の眼科　91　(5)　671-675　2020/05
Publisher: (公社)日本眼科医会
ISSN： 0285-1326
経角膜硝子体切除を併用した眼内レンズ強膜内固定術3症例の検討

新田文彦, 國方彦志, 大友孝昭, 西口康二, 阿部俊明, 中澤徹

臨床眼科　74　(5)　582-588　2020/05
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
後天性単眼性上転筋麻痺の3例

吉田清香, 檜森紀子, 竹下孝之, 中澤徹

眼科臨床紀要　13　(4)　284-285　2020/04
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
近視を有する緑内障患者の3D T2強調MRIによる眼球形状と体積の定量的解析

面高宗子, 舘脇康子, 檜森紀子, 津田聡, 武藤達士, ティロー・バンジャマン, 松平泉, 川島隆太, 瀧靖之, 中澤徹

日本眼科学会雑誌　124　(臨増)　172-172　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
マイクロパルス波経強膜毛様体光凝固術後の6ヵ月間成績

小杉真代, 津田聡, 國分太貴, 前川重人, 横山悠, 中澤徹

日本眼科学会雑誌　124　(臨増)　176-176　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
家兎濾過手術モデルでの偏光OCTの瘢痕定量評価と組織学的所見の関連性

國分太貴, 津田聡, 浅野俊文, 鈴木哲章, 前川重人, 横山悠, 佐藤孝太, 中澤徹

日本眼科学会雑誌　124　(臨増)　214-214　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Cornea hysteresisと濾過手術成績との関連

内田惠子, 檜森紀子, 國分太貴, 二宮高洋, 志賀由己浩, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　124　(臨増)　214-214　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
近視を有する緑内障患者の3D T2強調MRIによる眼球形状と体積の定量的解析

面高宗子, 舘脇康子, 檜森紀子, 津田聡, 武藤達士, ティロー・バンジャマン, 松平泉, 川島隆太, 瀧靖之, 中澤徹

日本眼科学会雑誌　124　(臨増)　172-172　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
乳頭周囲網脈絡膜萎縮部血流と緑内障視野障害進行の関連

清田直樹, 志賀由己浩, 高橋成奈, 安田正幸, 面高宗子, 津田聡, 國方彦志, 中澤徹

日本眼科学会雑誌　124　(臨増)　172-172　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
OCTのenface画像を用いた視力と関連する網膜神経線維束の検出

高橋直樹, 面高宗子, 木川勉, 秋葉正博, 中澤徹

日本眼科学会雑誌　124　(臨増)　173-173　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
オミデネパグイソプロピル(エイベリス点眼液0.002%)の多施設観察研究/3ヵ月中間報告

中澤徹, 高橋寛二, 桑山泰明, 野村明生, 島田史規

日本眼科学会雑誌　124　(臨増)　175-175　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
マイクロパルス波経強膜毛様体光凝固術後の6ヵ月間成績

小杉真代, 津田聡, 國分太貴, 前川重人, 横山悠, 中澤徹

日本眼科学会雑誌　124　(臨増)　176-176　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ウサギ模擬白内障手術を用いたグルタチオン三硫化物(GS3G)による眼組織保護効果の検討

鈴木哲章, 國方彦志, 俵山寛司, 佐藤孝太, 津田聡, 中澤徹

日本眼科学会雑誌　124　(臨増)　183-183　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
家兎濾過手術モデルでの偏光OCTの瘢痕定量評価と組織学的所見の関連性

國分太貴, 津田聡, 浅野俊文, 鈴木哲章, 前川重人, 横山悠, 佐藤孝太, 中澤徹

日本眼科学会雑誌　124　(臨増)　214-214　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Cornea hysteresisと濾過手術成績との関連

内田惠子, 檜森紀子, 國分太貴, 二宮高洋, 志賀由己浩, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　124　(臨増)　214-214　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
家兎におけるカルパイン活性の生体内イメージング

浅野俊文, 津田聡, 國方彦志, 神谷真子, 浦野泰照, 中澤徹

日本眼科学会雑誌　124　(臨増)　234-234　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
広義原発開放隅角緑内障関連遺伝子領域の多型と酸化ストレスの関係

佐藤正隆, 橋本和軌, 志賀由己浩, 二宮高洋, 檜森紀子, 西口康二, 中澤徹

日本眼科学会雑誌　124　(臨増)　236-236　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜興奮毒性障害におけるマイクログリアの活性化とヘスペリジンによる抑制効果

前川重人, 佐藤孝太, 佐藤大夢, 中澤徹

日本眼科学会雑誌　124　(臨増)　237-237　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
開放隅角緑内障患者の前房水メタボローム解析

横山悠, 佐藤孝太, 三枝大輔, 藤岡周, 國分太貴, 前川重人, 津田聡, 面高宗子, 中澤徹

日本眼科学会雑誌　124　(臨増)　238-238　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ハンフリー視野検査を利用した深層学習による緑内障性視野障害の進行予測

二宮高洋, 面高宗子, 高田菜生子, 橋本和軌, 中澤徹

日本眼科学会雑誌　124　(臨増)　261-261　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
深層学習による視神経乳頭出血の検出

橋本和軌, 面高宗子, 安光州, 新田耕治, 秋葉正博, 横田秀夫, 中澤徹

日本眼科学会雑誌　124　(臨増)　261-261　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
CRISPR/Cas9によるCrat遺伝子ノックアウト細胞標識ツールの開発

佐藤孝太, 片山翔太, 中澤徹

日本眼科学会雑誌　124　(臨増)　293-293　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者におけるMRIを用いた脳一次視覚野の部位別変化と各種眼科検査の関連

山田晃生, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　124　(臨増)　298-298　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
滲出型加齢黄斑変性における酸化ストレスの評価

安田正幸, 國方彦志, 内田惠子, 伊藤梓, 浅野俊文, 橋本和軌, 中澤徹

日本眼科学会雑誌　124　(臨増)　302-302　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障セミナー開放隅角緑内障のゲノムワイド関連解析緑内障診療における個別化医療実現に向けて

志賀由己浩, 中澤徹

あたらしい眼科　37　(2)　195-196　2020/02
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
【眼科領域の最新医療・プレシジョンメディシン】緑内障と非眼圧依存因子としての眼循環

志賀由己浩, 中澤徹

Precision Medicine　3　(2)　108-111　2020/02
Publisher: (株)北隆館
ISSN： 2434-3625
緑内障における眼血流改善治療の可能性

清田直樹, 中澤徹

臨床眼科　74　(1)　2020

ISSN： 0370-5579
視野シミュレーション眼鏡の開発と整合性・有用性の検討

高津育美, 鈴鴨よしみ, 谷口広明, 青柳祐也, 中澤徹

日本ロービジョン学会学術総会プログラム・抄録集　21st (Web)　2020
Multiplex PCRにてヒトヘルペスウイルス6,7陽性となった症例の特徴

針谷威寛, 横倉俊二, 小林航, 吉田正彰, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　44th-36th　2020
Plectosphaerella cucumerinaによる真菌性角膜炎の一例

桐山卓也, 吉田真彰, 針谷威寛, 渡辺みか, 勝見真琴, 戸所大輔, 小林航, 横倉俊二, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　44th-36th　2020
角膜内皮移植手術時の前房水中サイトカインと術後角膜内皮細胞密度の予後

岡部達, 針谷威寛, 横倉俊二, 小林航, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　44th-36th　2020
翼状片における複屈折値と前眼部OCTパラメーターとの関連解析

小林航, 横倉俊二, 針谷威寛, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　44th-36th　2020
初発翼状片頭部の複屈折と高次収差の相関についての解析

横倉俊二, 小林航, 針谷威寛, 吉田真彰, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　44th-36th　2020
【高齢者と眼疾患】緑内障と加齢

前川重人, 中澤徹

Pharma Medica　37　(12)　29-32　2019/12
Publisher: (株)メディカルレビュー社
ISSN： 0289-5803
糖尿病患者における黄斑部表層毛細血管密度と視神経乳頭血流波形パラメータの関連

安田正幸, 國方彦志, 澤田正二郎, 伊藤梓, 佐竹千尋, 片桐秀樹, 中澤徹

眼科臨床紀要　12　(10)　772-772　2019/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
早期糖尿病網膜症患者における浅層中心窩無血管領域と心臓足首血管指数の関連

伊藤梓, 國方彦志, 澤田正二郎, 安田正幸, 佐竹千尋, 片桐秀樹, 中澤徹

眼科臨床紀要　12　(10)　772-772　2019/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
緑内障患者における抗酸化力と角膜可塑性の関連

内田惠子, 檜森紀子, 橋本和樹, 志賀由己浩, 面高宗子, 津田聡, 中澤徹

日本緑内障学会抄録集　30回　183-183　2019/09
Publisher: 日本緑内障学会
開放隅角緑内障1家系におけるOPTN遺伝子の新規N51T変異の同定

前川重人, 橋本和軌, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 西口康二, 中澤徹, 日本緑内障学会遺伝子研究班

日本緑内障学会抄録集　30回　184-184　2019/09
Publisher: 日本緑内障学会
緑内障病型別の線維柱帯切開術(眼内法)の短期術後成績

山口知暁, 横山悠, 山田晃生, 津田聡, 志賀由己浩, 前川重人, 中澤徹

日本緑内障学会抄録集　30回　81-81　2019/09
Publisher: 日本緑内障学会
隅角色素沈着量と開放隅角緑内障の線維柱帯切開術(眼内法)の短期術後成績

横山悠, 山田晃生, 津田聡, 志賀由己浩, 前川重人, 中澤徹

日本緑内障学会抄録集　30回　81-81　2019/09
Publisher: 日本緑内障学会
Detecting glaucomatous change with magnetic resonance imaging of the brain primary visual cortex

Akio Yamada, Kazuko Omodaka, Yasuko Tatewaki, Noriko Himori, Izumi Matsudaira, Taki Yasuyuki, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　60　(9)　2019/07

ISSN： 0146-0404

eISSN： 1552-5783
Prediction of glaucomatous visual field progression by genetic variants associated with primary open-angle glaucoma

Fumihiko Mabuchi, Yoichi Sakurada, Kenji Kashiwagi, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuki Hashimoto, Kota Sato, Yukihiro Shiga, Koji Nishiguchi, Toru Nakazawa, Masato Akiyama, Kazuhide Kawase, Mineo Ozaki, Makoto Araie

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　60　(9)　2019/07

ISSN： 0146-0404

eISSN： 1552-5783
2型糖尿病患者におけるLaser speckle flowgraphyによる視神経乳頭領域の眼血流指標と超音波検査による頸動脈血流指標との関係

澤田正二郎, 佐竹千尋, 國方彦志, 安田正幸, 伊藤梓, 黒澤聡子, 児玉慎二郎, 山本淳平, 金子慶三, 今井淳太, 中澤徹, 片桐秀樹

糖尿病　62　(Suppl.1)　S-128　2019/04
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X

eISSN： 1881-588X
2型糖尿病患者におけるLaser speckle flowgraphyによる視神経乳頭領域の眼血流指標と超音波検査による頸動脈血流指標との関係

澤田正二郎, 佐竹千尋, 國方彦志, 安田正幸, 伊藤梓, 黒澤聡子, 児玉慎二郎, 山本淳平, 金子慶三, 今井淳太, 中澤徹, 片桐秀樹

糖尿病　62　(Suppl.1)　S-128　2019/04
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X
Retina Medicine座談会『AIと眼科診療』

NAKAZAWA Toru

Retina Medicine　8　(1)　1-9　2019/04
Publisher: (株)先端医学社
ISSN： 2187-2384
MRIを用いた脳一次視覚野の部位別の緑内障性変化の検出

山田晃生, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　123　(臨増)　222-222　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Mitomycin C併用緑内障濾過手術におけるColchicine点眼の有効性の検討

國分太貴, 山本耕太郎, 赤石貴浩, 島崎敦, 中村雅胤, 佐藤孝太, 中澤徹

日本眼科学会雑誌　123　(臨増)　242-242　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Flammer症候群問診スコアと寒冷負荷試験に対する血管応答の関連

高橋成奈, 志賀由己浩, 清田直樹, 安田正幸, 佐藤茉莉華, 津田聡, 面高宗子, 檜森紀子, 高山真, 石井正, 中澤徹

日本眼科学会雑誌　123　(臨増)　221-221　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
滲出性網膜剥離を発症し、診断に苦慮した網膜血管腫の一例

橋本清香, 國方彦志, 油井奈保子, 西口康二, 阿部俊明, 中澤徹

眼科臨床紀要　12　(3)　253-253　2019/03
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
高酸素血症時の血管応答性とその後の緑内障視野障害進行の関連

清田直樹, 志賀由己浩, 安田正幸, 相澤奈帆子, 面高宗子, 津田聡, 國方彦志, 中澤徹

日本眼科学会雑誌　123　(臨増)　156-156　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
特発性黄斑前膜術後の網膜感度と術前の黄斑血管密度との関係

長田麗, 國方彦志, 安田正幸, 橋本和軌, 相澤奈帆子, 西田康二, 阿部俊明, 中澤徹

日本眼科学会雑誌　123　(臨増)　173-173　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
特発性黄斑前膜の術後網膜内層厚と術前黄斑部血管密度の部位別関連

安田正幸, 國方彦志, 長田麗, 橋本和軌, 中澤徹

日本眼科学会雑誌　123　(臨増)　206-206　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
健常者におけるOCT-Angiographyによるradial peripapillary capillary密度マップ

面高宗子, 木川勉, 浅野俊文, 津田聡, 國方彦志, 秋葉正博, 中澤徹

日本眼科学会雑誌　123　(臨増)　221-221　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
画像でみる緑内障の病態

TAKADA Naoko, NAKAZAWA Toru

Frontiers in Glaucoma　(57)　1-5　2019/03
Effects of Anti-allergic Eye Drops on Histamine Receptors in Patients with Seasonal Allergic Conjunctivitis

針谷威寛, 丸山和一, 丸山和一, 横倉俊二, 中澤徹

あたらしい眼科　36　(2)　273-281　2019/02
Publisher: メディカル葵出版
ISSN： 0910-1810
緑内障性視野障害の評価における深層学習の有用性の検討

二宮高洋, 面高宗子, 橋本和軌, 高田菜生子, 中澤徹

日本緑内障学会抄録集　30th　2019
MRIを用いた緑内障患者の眼球形態の検討

國時景子, 國時景子, 舘脇康子, 面高宗子, 松平泉, THYREAU Benjamin, 武藤達士, 川島隆太, 中澤徹, 瀧靖之, 瀧靖之

日本疫学会学術総会講演集(Web)　29th　2019
LSFG

清田直樹, 中澤徹

眼科グラフィック　8　(4)　2019

ISSN： 2187-2422
iPS細胞由来立体網膜組織構造における網膜神経節細胞マーカーの発現

小林航, 大西暁士, 高橋政代, 中澤徹

日本再生医療学会総会(Web)　18th　2019
免疫正常患者における難治性両眼単純ヘルペス角膜炎の一例

岡部達, 針谷威寛, 小林航, 横倉俊二, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　43rd-35th　2019
円錐角膜症例における視力と前眼部パラメーターの関連解析

小林航, 横倉俊二, 針谷威寛, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　43rd-35th　2019
三叉神経麻痺と顔面神経麻痺合併例に大腿被覆神経移植を行った2例

横倉俊二, 針谷威寛, 小林航, 館正弘, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　43rd-35th　2019
角膜感染症におけるMultiplex PCRストリップによる病原体の検索

針谷威寛, 横倉俊二, 小林航, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　43rd-35th　2019
単一AAVベクターによる変異置換ゲノム編集とマウス網膜機能再建

西口康二, 藤田幸輔, 中澤徹

日本分子生物学会年会プログラム・要旨集(Web)　42nd　2019
メタボローム解析による緑内障バイオマーカー探索と個別化医療への応用

中澤徹

日本眼薬理学会プログラム・講演抄録集　39th　2019
網膜神経節細胞障害によるMCP-1誘導とヘスペリジンによる抑制効果

佐藤孝太, 藤田幸輔, 前川重人, 佐藤大夢, 中澤徹

日本緑内障学会抄録集　30th　2019
ミトコンドリアComplex I阻害によるマウス網膜グリア細胞変化の検討

柳町真希, 檜森紀子, 佐藤孝太, 山本雅之, 中澤徹

日本緑内障学会抄録集　30th　2019
赤外光を用いた斜光照明による眼底撮影装置の製作

竹山佳那, NEELAM Kaushik, 佐々木敬, 中澤徹, 羽根一博

センサ・マイクロマシンと応用システムシンポジウム(CD-ROM)　36th　2019
en-Face Swept Source OCT画像による網膜神経線維層欠損面積の新規解析方法

高橋直樹, 面高宗子, 木川勉, 高橋世理, 秋葉正博, 中澤徹

日本眼科学会雑誌　123　2019

ISSN： 0029-0203
PDHK阻害薬は代謝異常の是正を通じて網膜虚血再灌流障害に対して保護効果を示す

持田誠也, 持田誠也, 佐藤孝太, 中澤徹

日本眼科学会雑誌　123　2019

ISSN： 0029-0203
AAV2-CRISPR/Cas9システムを用いた網膜神経節細胞のゲノム編集

佐藤孝太, 藤田幸輔, 俵山寛司, 片山翔太, 西口康二, 中澤徹

日本眼科学会雑誌　123　2019

ISSN： 0029-0203
抗VEGF剤徐放デバイスによる実験的脈絡膜新生血管の抑制

永井展裕, 大學玲子, 梶弘和, 西澤松彦, 中澤徹, 阿部俊明

日本眼科学会雑誌　123　2019

ISSN： 0029-0203
B群溶血性連鎖球菌による内因性眼内炎の6例

吉田真彰, 横倉俊二, 西田崇, 望月清文, 鈴木崇, 丸山和一, 丸山和一, 西口康二, 國方彦志, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　56th-53rd-62nd-8th　2019
2型糖尿病患者におけるLaser speckle flowgraphyによる視神経乳頭領域の眼血流指標と超音波検査による頸動脈血流指標との関係

澤田正二郎, 佐竹千尋, 國方彦志, 安田正幸, 伊藤梓, 黒澤聡子, 児玉慎二郎, 山本淳平, 金子慶三, 今井淳太, 中澤徹, 片桐秀樹

糖尿病(Web)　62　(Suppl)　2019

ISSN： 1881-588X
前眼部偏光OCTによる線維柱帯切除術後の濾過胞評価

國分太貴, 津田聡, 山成正宏, 國方彦志, 前川重人, 横山悠, 檜森紀子, 面高宗子, 中澤徹

日本緑内障学会抄録集　30th　2019
網膜神経節細胞複合体からマイクロペリメータMP-3を用いた網膜感度予測式の検討

菅野雅浩, 面高宗子, PAK Kyongsun, 山田祥之, 本田昂, 高津育美, 國方彦志, 本多直人, 中澤徹

日本緑内障学会抄録集　30th　2019
日本人のヒット論文-本音で語る苦労話(第15回)

澤田有, 中澤徹, 山城健児

Retina Medicine　8　(2)　169-174　2019
緑内障研究の紹介

中澤徹

Neuro Global 国際共同大学院プログラム　51-52　2019
特集緑内障撲滅プロジェクト-緑内障の予防と治療への取組み

NAKAZAWA Toru

87　3-4　2019
【感覚器障害の治療と研究の最前線 QOL向上とコミュニケーションのあり方を考える】先進感覚器研究コアセンターの感覚器研究プロジェクト

國方彦志, 佐藤孝太, 俵山寛司, 中澤徹

ファルマシア　54　(11)　1025-1029　2018/11
Publisher: (公社)日本薬学会
ISSN： 0014-8601

eISSN： 2189-7026
新しい眼科病診連携システムの網膜疾患診療における有用性

國方彦志, 加藤圭一, 齋藤慶治, 檜森紀子, 相澤奈帆子, 西口康二, 中山雅晴, 阿部俊明, 中澤徹

眼科臨床紀要　11　(11)　856-857　2018/11
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
Pars plana vitrectomy with endolaser cyclophotocoagulation for refractory glaucoma in eleven eyes

高橋成奈, 横山悠, 國方彦志, 西口康二, 新田文彦, 竹下孝之, 中澤徹

臨床眼科　72　(10)　1451-1458　2018/10
Publisher: 医学書院
ISSN： 0370-5579
篩状板と緑内障

OMODAKA Kazuko, NAKAZAWA Toru

眼科　60　(11)　2018/10
『緑内障診断への光干渉断層血管撮影の応用』日本眼科学雑誌 122（9）：671-673 平成30年

NAKAZAWA Toru

2018/09
続発緑内障の分類と治療法の基本的な考え方—Classification and Treatment of Secondary Glaucoma—特集続発緑内障

横山悠, 中澤徹

あたらしい眼科 / メディカル葵出版 [編]　35　(8)　1009-1015　2018/08
Publisher: 東京 : メディカル葵出版
ISSN： 0910-1810
画像でみる緑内障の病態

AIZAWA Naoko, NAKAZAWA Toru

Frontiers in Glaucoma　(56)　2018/08
術前の眼圧測定が診断に有用であった先天性片眼上転障害の一例

橋本清香, 佐藤美保, 中澤徹

眼科臨床紀要　11　(4)　296-296　2018/04
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
生涯アカデミック宣言!

石田晋, 小沢洋子, 尾花明, 栗山晶治, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児

Retina Medicine　7　(1)　1-8　2018/04
Publisher: (株)先端医学社
ISSN： 2187-2384
レドックスと疾患 16.眼疾患と酸化ストレス

國方彦志, 中澤徹

実験医学　36　(5)　831‐836　2018/03/15

ISSN： 0288-5514
POAGとNVGにおける線維柱帯切除術後の濾過胞構造変化の比較

國分太貴, 津田聡, 相澤奈帆子, 檜森紀子, 横山悠, 面高宗子, 国松志保, 國方彦志, 中澤徹

日本眼科学会雑誌　122　(臨増)　160-160　2018/03/09
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
高眼圧眼における眼圧下降時の眼血流動態

志賀由己浩, 清田直樹, 面高宗子, 鈴木詩織, 國方彦志, 中澤徹

日本眼科学会雑誌　122　(臨増)　211-211　2018/03/09
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
10代若年の外傷性黄斑円孔に対する水晶体温存MIVSの治療成績

鈴木哲章, 國方彦志, 相澤奈帆子, 阿部俊明, 中澤徹

日本眼科学会雑誌　122　(臨増)　267-267　2018/03/09
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
黄斑前膜手術が緑内障患者の視野へ与える影響の検討

吉田真彰, 國方彦志, 国松志保, 中澤徹

日本眼科学会雑誌　122　(臨増)　221-221　2018/03/09
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
健常眼における眼圧負荷時の眼血流動態

清田直樹, 志賀由己浩, 一迫弘平, 鈴木詩織, 吉田みなみ, 國方彦志, 中澤徹

日本眼科学会雑誌　122　(臨増)　210-210　2018/03/09
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
眼血流低下型緑内障の検出方法とその特徴

藤岡俊亮, 面高宗子, 安光州, 津田聡, 志賀由己浩, 木川勉, 秋葉正博, 横田秀夫, 中澤徹

日本眼科学会雑誌　122　(臨増)　212-212　2018/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
他分野の基礎研究から学ぶ最先端研究メタボローム解析を応用した個別化医療

三枝大輔, 佐藤孝太, 齋藤律水, 元池育子, 中澤徹, 山本雅之

日本眼科学会雑誌　122　(臨増)　30-30　2018/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
【レドックス疾患学酸素・窒素・硫黄活性種はどう作用するのか、どこまで健康・疾患と関わるのか?】(第2章)レドックスと疾患眼疾患と酸化ストレス

國方彦志, 中澤徹

実験医学　36　(5)　831-836　2018/03
Publisher: (株)羊土社
ISSN： 0288-5514
【進化するOCT活用術-基礎から最新まで-】緑内障

津田聡, 中澤徹

OCULISTA　(60)　17-26　2018/03
Publisher: (株)全日本病院出版会
ISSN： 2187-5855
OCTAによる乳頭周囲と黄斑部における微小循環間の関係

國方彦志, 浅野俊文, 相澤奈帆子, 佐藤里咲, 加藤圭一, 中澤徹

日本眼科学会雑誌　122　(臨増)　232-232　2018/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
OCTAによる正常網膜乳頭周囲毛細血管に関する検討

浅野俊文, 國方彦志, 相澤奈帆子, 佐藤里咲, 加藤圭一, 中澤徹

日本眼科学会雑誌　122　(臨増)　212-212　2018/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
OCT‐Angiographyによるradial peripapillary capillary密度の緑内障診断力

津田聡, 面高宗子, 木川勉, 浅野俊文, 國方彦志, 相見太樹, 秋葉正博, 中澤徹

日本眼科学会雑誌　122　(臨増)　211-211　2018/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜動脈分枝閉塞症における初診時視力不良に関連する因子の検討

安田正幸, 橋本和軌, 針谷威寛, 中山紘子, 浅野俊文, 鈴木哲章, 宗像正徳, 中澤徹, 佐藤肇

日本眼科学会雑誌　122　(臨増)　186-186　2018/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜中心動脈閉塞症に対する高圧酸素療法の治療効果と治療後視力に関連する因子の検討

橋本和軌, 安田正幸, 針谷威寛, 中山紘子, 浅野俊文, 鈴木哲章, 宗像正徳, 中澤徹, 佐藤肇

日本眼科学会雑誌　122　(臨増)　268-268　2018/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ステレオ眼底カメラにより計測した網膜血管径および視神経乳頭形状パラメーターの関連

杉原一暢, 高井保幸, 谷戸正樹, 川崎良, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 大久保真司, 松本長太, 杉山和久, 中澤徹, 大平明弘

眼科臨床紀要　11　(3)　236-236　2018/03
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
ステレオ眼底カメラにより分類した緑内障視神経乳頭形状分類と網膜血管径の関連

高井保幸, 杉原一暢, 谷戸正樹, 川崎良, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 大久保真司, 松本長太, 杉山和久, 中澤徹, 大平明弘

眼科臨床紀要　11　(3)　236-236　2018/03
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
涙嚢憩室炎を併発した涙嚢内菌石症の1例

目黒泰彦, 目黒真里絵, 横倉俊二, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　55th-52nd-61st-7th　2018
線維柱帯切除術施行患者における全身循環動態の検討

二宮高洋, 津田聡, 國分太貴, 志賀由己浩, 面高宗子, 檜森紀子, 横山悠, 国松志保, 中澤徹

日本緑内障学会抄録集　29th　2018
全層角膜移植手術時の前房水中サイトカインと術後角膜内皮細胞密度の予後

針谷威寛, 横倉俊二, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　42nd-34th　2018
瘢痕化角膜眼における前房内サイトカイン解析

横倉俊二, 針谷威寛, 中澤徹

日本角膜学会総会・日本角膜移植学会プログラム・抄録集　42nd-34th　2018
副腎白質ジストロフィー罹患中にレーベル遺伝性視神経症を発症した1例

檜森紀子, 竹下孝之, 吉田清香, 三島史子, 中澤徹

神経眼科　35　2018

ISSN： 0289-7024
緑内障における乳頭黄斑神経線維束厚と視力低下の関連

高橋直樹, 面高宗子, 福岡世理, 木川勉, 秋葉正博, 中澤徹

日本緑内障学会抄録集　29th　2018
緑内障濾過手術におけるDNA topoisomerase II阻害薬の有効性の検討

國分太貴, 山本耕太郎, 赤石貴浩, 島崎敦, 中村雅胤, 佐藤孝太, 中澤徹

日本緑内障学会抄録集　29th　2018
視放線における緑内障性神経変化のDTI-NODDIによる検出

山田晃生, 面高宗子, 舘脇康子, 松平泉, 下地啓五, 齊藤麻美, 川島隆太, 瀧靖之, 中澤徹

日本緑内障学会抄録集　29th　2018
3D立体構造における篩状板孔の主成分解析や真球度について

前川重人, 面高宗子, AN Guangzhou, AN Guangzhou, 松本朗子, 木川勉, 木川勉, 秋葉正博, 秋葉正博, 横田秀夫, 中澤徹

日本緑内障学会抄録集　29th　2018
開放隅角緑内障に関わる新たな遺伝子領域の同定

志賀由己浩, 秋山雅人, 西口康二, 佐藤孝太, 三宅正裕, 山城健児, 桃沢幸秀, 鎌谷洋一郎, 久保充明, 中澤徹

日本緑内障学会抄録集　29th　2018
ブリモニジンまたはチモロールで24ヶ月間治療された原発開放隅角緑内障における視野障害進行関連因子の検討

横山悠, 川崎良, 高橋秀肇, 前川重人, 津田聡, 面高宗子, 中澤徹

日本緑内障学会抄録集　29th　2018
日本人原発開放隅角緑内障感受性遺伝子領域におけるリスクアレルの臨床的特徴

橋本和軌, 志賀由己浩, 西口康二, 三宅正裕, 山城健児, 河合洋介, 長崎正朗, 中澤徹

日本緑内障学会抄録集　29th　2018
OCTAを用いた放射状乳頭周囲血管網の血管密度解析の再現性の検討

新妻未央, 面高宗子, 福岡世理, 吉田みなみ, 山本光男, 中澤徹

日本緑内障学会抄録集　29th　2018
正常眼における篩状板部血管密度の計測方法の検討

河本絵里香, 面高宗子, 堀江寿雲, 福岡世理, 中澤徹

日本緑内障学会抄録集　29th　2018
視細胞に対するin vivoゲノム編集を目的としたAAV-PITChシステムの開発

西口康二, 西口康二, 藤田幸輔, 片山翔太, 中澤徹, 中澤徹, 中澤徹

日本分子生物学会年会プログラム・要旨集(Web)　41st　2018
タフルプロスト徐放性製剤によるラット網膜神経節細胞への神経保護効果の検討

中川優梨花, 佐藤孝太, 面高宗子, 浅田博之, 藤井忍, 眞崎賢治, 中澤徹

日本緑内障学会抄録集　29th　2018
chop経路阻害はヘスペリジンによる網膜神経保護作用を増強する

佐藤孝太, 中川優梨花, 前川重人, 中澤徹

日本眼科学会雑誌　122　2018

ISSN： 0029-0203
ヒトiPS細胞由来3次元立体網膜組織からImmunopanning法及びMACS法で単離精製した網膜神経節細胞の比較

小林航, 大西暁士, 井関恭子, 瀧原祐史, 稲谷大, 中澤徹, 杉田直, 高橋政代

日本再生医療学会総会(Web)　17th　2018
NMDA誘導性網膜障害時におけるヘスペリジンの抗炎症作用

佐藤大夢, 佐藤孝太, 前川重人, 中澤徹

日本眼科学会雑誌　122　2018

ISSN： 0029-0203
有効な検査から見えてくる新たな緑内障の世界

中澤徹

Japanese Orthoptic Journal　47　2018

ISSN： 0387-5172
緑内障患者におけるFlammer問診票の有用性

高橋成奈, 志賀由己浩, 安田正幸, 佐藤茉莉華, 清田直樹, 津田聡, 面高宗子, 檜森紀子, 高山真, 石井正, 中澤徹

日本緑内障学会抄録集　29th　2018
日本緑内障学会遺伝子研究班の活動報告

中澤徹, 志賀由己浩, 西口康二, 間渕文彦, 柏木賢治, 高本光子, 相原一, 尾崎峯生, 川瀬和秀, 岩田岳, 新家眞

日本緑内障学会抄録集　29th　2018
抗VEGF抗体徐放デバイスの経強膜投与による実験的脈絡膜新生血管抑制

永井展裕, 大学玲子, 寺田慧子, 梶弘和, 西澤松彦, 中澤徹, 阿部俊明

日本DDS学会学術集会プログラム予稿集　34th　2018
視神経挫滅モデル網膜のメタボローム解析

佐藤孝太, 三枝大輔, 元池育子, 齋藤律水, 藤岡周, 山本雅之, 中澤徹

日本緑内障学会抄録集　29th　2018
OCTアンジオグラフィによる黄斑剥離裂孔原性網膜剥離眼の検討

油井奈保子, 國方彦志, 相澤奈帆子, 新田文彦, 大友孝昭, 西口康二, 阿部俊明, 中澤徹

日本眼循環学会講演抄録集　35th　2018
緑内障患者のベースライン4分割視神経乳頭組織血流が対応する部位の視野進行に与える影響

清田直樹, 志賀由己浩, 安田正幸, 相澤奈帆子, 面高宗子, 津田聡, 檜森紀子, 國方彦志, 中澤徹

日本緑内障学会抄録集　29th　76　2018
中心視野障害を伴う緑内障患者の黄斑部OCTAパラメーター

佐藤里咲, 國方彦志, 面高宗子, 浅野俊文, 志賀由己浩, 木川勉, 秋葉正博, 中澤徹

日本緑内障学会抄録集　29th　115　2018
緑内障患者におけるミトコンドリア障害マーカーとしてのmtDNA/nDNA比と視神経乳頭組織血流の検討

柳町真希, 檜森紀子, 佐藤孝太, 國分太貴, 浅野俊文, 志賀由己浩, 津田聡, 國方彦志, 中澤徹

日本緑内障学会抄録集　29th　77　2018
前視野緑内障眼での視野進行に関与する因子の検討

相澤奈帆子, 國方彦志, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 国松志保, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　29th　76　2018
先進感覚器研究コアセンターの感覚器研究プロジェクト

國方彦志, 佐藤孝太, 俵山寛司, 中澤徹

ファルマシア(Web)　54　(11)　1025‐1029(J‐STAGE)　2018

DOI： 10.14894/faruawpsj.54.11_1025 　

ISSN： 2189-7026
マイクロペリメータMP‐3の網膜感度とRGC displacementを考慮した黄斑部網膜層厚との相関

本田昂, 面高宗子, 石川奈津美, 本多直人, 山田祥之, 國方彦志, 中澤徹

日本緑内障学会抄録集　29th　79　2018
MMWINを活用したデータベースの構築,病診連携システムの確立

檜森紀子, 國方彦志, 加藤圭一, 吉田清香, 志賀由己浩, 齋藤慶治, 中山雅晴, 中澤徹

日本緑内障学会抄録集　29th　68　2018
新規開発蛍光プローブを用いたカルパイン活性の評価

津田聡, 津田聡, 浅野俊文, 伊藤梓, 佐藤孝太, 藤田幸輔, 國方彦志, 神谷真子, 浦野泰照, 中澤徹

日本緑内障学会抄録集　29th　128　2018
新規開発蛍光プローブを用いたカルパイン活性の生体内イメージング

浅野俊文, 津田聡, 伊藤梓, 佐藤孝太, 藤田幸輔, 國方彦志, 神谷真子, 浦野泰照, 中澤徹

日本緑内障学会抄録集　29th　127　2018
糖尿病患者における黄斑部表層毛細血管密度と視神経乳頭血流波形パラメータの関連

安田正幸, 國方彦志, 澤田正二郎, 伊藤梓, 佐竹千尋, 片桐秀樹, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　57th　70　2018
早期糖尿病網膜症患者における浅層中心窩無血管領域と心臓足首血管指数の関連

伊藤梓, 國方彦志, 澤田正二郎, 安田正幸, 佐竹千尋, 片桐秀樹, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　57th　71　2018
緑内障診療ガイドライン(第4版)

谷原秀信, 相原一, 稲谷大, 井上俊洋, 木内良明, 杉山和久, 富田剛司, 中澤徹, Nakamura Makoto, 東出朋巳, 福地健郎

日本眼科学会雑誌　122　(1)　5-53　2018/01
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
『Retina Medicine』座談会「生涯アカデミック宣言！」Retina Medicine Vol.7,No,1.2018春号

NAKAZAWA Toru

2018
OCTAを用いた網膜静脈分岐閉塞症における網膜血管の構造的および機能的変化の評価

NAKAZAWA Toru

Retina Medicine　17　(2)　2018
NITTAN ASEAN ベトナム現地法人設立

中澤徹

月刊フェスク : 消防・防災関係者のための最新情報誌　(432)　38-40　2017/10
Publisher: 東京 : 日本消防設備安全センター
ISSN： 1343-5116
全身性エリテマトーデス患者における眼血流解析

伊藤梓, 國方彦志, 安田正幸, 相澤奈帆子, 石井智徳, 中澤徹

眼科臨床紀要　10　(10)　849-849　2017/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
New Information of Glaucoma 前視野緑内障

津田聡, 中澤徹

Frontiers in Glaucoma　(54)　156-161　2017/09
Publisher: (株)メディカルレビュー社
ISSN： 1345-854X
Ocular blood flow in glaucoma

59　(6)　573-580　2017/06
Publisher: 金原出版
ISSN： 0016-4488
ウノプロストン徐放デバイスのサル強膜上12ヵ月間留置における眼内動態と眼毒性評価

永井展裕, 山田慎二, 西條早絢, 川崎淳一, 梶弘和, 中澤徹, 西澤松彦, 阿部俊明

日本DDS学会学術集会プログラム予稿集　33回　212-212　2017/06
Publisher: 日本DDS学会
Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters from ophthalmic examination instruments

117　(47)　63-66　2017/05/25
Publisher: 電子情報通信学会
ISSN： 0913-5685
前視野緑内障眼における中心視野障害進行と視神経乳頭組織血流の関係性

相澤奈帆子, 國方彦志, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　121　(臨増)　206-206　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者における抗酸化力と網膜神経節細胞数の関係

浅野良視, 檜森紀子, 山崎舞, 志賀由己浩, 面高宗子, 國方彦志, 中澤徹

日本眼科学会雑誌　121　(臨増)　185-185　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
光干渉断層計アンギオグラフィーとレーザースペックルフローグラフィーの有用性の比較

清田直樹, 國方彦志, 志賀由己浩, 面高宗子, 中澤徹

日本眼科学会雑誌　121　(臨増)　211-211　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
前眼部OCTを用いた線維柱帯切除術後の予後予測の検討

國分太貴, 津田聡, 國方彦志, 横山悠, 檜森紀子, 国松志保, 丸山和一, 中澤徹

日本眼科学会雑誌　121　(臨増)　245-245　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
MRIにおける広範な脳視覚野の緑内障性変化と部位間の相関

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本眼科学会雑誌　121　(臨増)　225-225　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
How should we manage a patient progressing at low levels of IOP?

71　(3)　309-316　2017/03
Publisher: 医学書院
ISSN： 0370-5579
前視野緑内障眼におけるプロスタグランジン関連薬による乳頭血流改善効果に関する検討

横山悠, 志賀由己浩, 相澤奈帆子, 津田聡, 清田直樹, 前川重人, 面高宗子, 米谷優輝子, 国松志保, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　121　(臨増)　281-281　2017/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
マウス緑内障モデル網膜のメタボローム解析

佐藤孝太, 三枝大輔, 斉藤律水, 中澤徹

日本眼科学会雑誌　121　(臨増)　186-186　2017/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
早発型発達緑内障における原因遺伝子の探索

布施昇男, 木村雅恵, 清水愛, 河合洋介, 小島要, 長崎正朗, 濱中輝彦, 石田誠夫, 中村誠, 酒井寛, 池田陽子, 森和彦, 中澤徹, 勝岡史城, 安田純, 山本雅之

日本眼科学会雑誌　121　(臨増)　227-227　2017/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
日本人正常眼の乳頭周囲網脈絡膜萎縮と関連因子

宇田川さち子, 東出朋巳, 大久保真司, 杉山和久, 岩瀬愛子, 富田剛司, 谷原秀信, 中澤徹, 板谷正紀, 新家眞

日本眼科学会雑誌　121　(臨増)　209-209　2017/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
『眼科診療マイスターⅡ 診断と治療』株式会社メジカルビュー社

NAKAZAWA Toru

2017/03
『眼科診療マイスターⅢ 処置と手術手技』株式会社メジカルビュー社 2017/3/10

NAKAZAWA Toru

2017/03
アレルギー性結膜炎に対する抗アレルギー点眼液のヒスタミン受容体発現に及ぼす影響

針谷威寛, 丸山和一, 横倉俊二, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　54th-51st-60th-6th　2017
急性骨髄性白血病治療中に発症したFusarium solaniによる内因性眼内炎の1例

吉田真彰, 丸山和一, 清田直樹, 豊川真弘, 荻原繁広, 槇村浩一, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　54th-51st-60th-6th　2017
前視野緑内障

津田聡, 中澤徹

Frontiers in Glaucoma　(54)　2017

ISSN： 1345-854X
日本人正常眼での近視乳頭形状と乳頭周囲脈絡網膜萎縮との関連

宇田川さち子, 東出朋巳, 大久保真司, 杉山和久, 岩瀬愛子, 富田剛司, 谷原秀信, 中澤徹, 板谷正紀, 新家眞, 新家眞

日本緑内障学会抄録集　28th　2017
緑内障患者におけるMRIの視覚野体積と視野重症度との関連

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　28th　2017
ステレオ眼底カメラで計測した視神経乳頭形状パラメータと乳頭周囲網脈絡膜萎縮面積を用いた乳頭形状分類

藤岡俊亮, 横山悠, 谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 中澤徹, 岩瀬愛子

日本緑内障学会抄録集　28th　2017
複合サプリメント摂取による抗酸化力の変動

檜森紀子, 佐藤孝太, 中澤徹

日本緑内障学会抄録集　28th　2017
en-Face Swept Source OCT画像による網膜神経線維層欠損角度の新規解析方法

遠藤拓弥, 面高宗子, 木川勉, 三浦直晃, 高橋世理, 秋葉正博, 中澤徹

日本緑内障学会抄録集　28th　2017
広義原発開放隅角緑内障眼における乳頭周囲網脈絡膜萎縮面積と視神経乳頭形状の関連

横山悠, 谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　28th　2017
ステレオ眼底カメラにより分類した緑内障視神経乳頭形状と網膜血管径の関連

高井保幸, 杉原一暢, 谷戸正樹, 川崎良, 大平明弘, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 大久保真司, 松本長太, 杉山和久, 中澤徹

日本緑内障学会抄録集　28th　2017
興奮毒性障害モデルに対する食品由来素材含有サプリメントの網膜保護効果の検討

前川重人, 前川重人, 佐藤孝太, 國分太貴, 中澤徹

日本緑内障学会抄録集　28th　2017
緑内障動物モデルによる神経保護治療開発のアプローチ

中澤徹

日本眼科学会雑誌　121　2017

ISSN： 0029-0203
緑内障 (特集 OCTで血管を斬る!)

清田直樹, 中澤徹

Retina medicine : journal of retina medeicine : 網膜・硝子体領域を中心とした医学情報誌　6　(2)　116-120　2017
Publisher: 先端医学社
ISSN： 2187-2384
Primary and secondary prevention for glaucoma

71　(1)　20-27　2017/01
Publisher: 医学書院
ISSN： 0370-5579
緑内障患者の前房水中サイトカインのプロファイルの検討

國分太貴, 津田聡, 國方彦志, 横山悠, 面高宗子, 檜森紀子, 国松志保, 丸山和一, 中澤徹

日本眼科学会雑誌　121　(1)　93-93　2017/01
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
新しい眼科病診連携システムの網膜疾患診療における有用性

國方彦志, 加藤圭一, 齋藤慶治, 檜森紀子, 相澤奈帆子, 西口康二, 中山雅晴, 阿部俊明, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　56th　132　2017
両眼トラベクレクトミーを施行した患者における術後成績についての後ろ向き多施設比較試験

岩崎健太郎, 高村佳弘, 西田崇, 澤田明, 岩尾圭一郎, 新村彩乃, 国松志保, 谷原秀信, 杉山和久, 中澤徹, 稲谷大

眼科臨床紀要　9　(12)　1029-1029　2016/12
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
『眼科診療マイスターⅠ 診察と検査』株式会社メジカルビュー社 2016/11/10

NAKAZAWA Toru

2016/11
妊娠経過中の視神経乳頭血流解析

相澤奈帆子, 佐藤孝洋, 國方彦志, 萱場寛子, 倉片三千代, 杉山隆, 菅原準一, 中澤徹

眼科臨床紀要　9　(10)　856-856　2016/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
糖尿病網膜症における強膜自発蛍光測定の有用性の検討

安田正幸, 國方彦志, 相澤奈帆子, 田中佑治, 永富良一, 中澤徹

眼科臨床紀要　9　(10)　853-854　2016/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
緑内障による失明を食い止めたい－個別化医療への挑戦〈https://academist-cf.com/journal/?p=2115）Academist Journal 2016/10/05

NAKAZAWA Toru

2016/10
編集室「学術集会の魅力」pp714－715、日本眼科学会雑誌第120巻10号,2016/10/10

NAKAZAWA Toru

2016/10
『全視野緑内障に向き合うーPPGを発見した時、どう管理するかー』株式会社文光堂2016/10/15

NAKAZAWA Toru

2016/10
Trabeculectomy in Both Eyes; the First-Operated Versus the Second-Operated Eyes: A Comparative, Multicenter Study

Kentaro Iwasaki, Yoshihiro Takamura, Takashi Nishida, Akira Sawada, Keiichiro Iwao, Ayano Shinmura, Shiho Kunimatsu-Sanuki, Hidenobu Tanihara, Kazuhisa Sugiyama, Toru Nakazawa, Masaru Inatani

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Clinical and radiological characteristics of optic neuritis in demyelinating disorder with serum anti-MOG antibody

I. Nakashima, T. Akaishi, T. Takeshita, D. K. Sato, K. Kaneko, T. Nakazawa, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　22　151-151　2016/09

ISSN： 1352-4585

eISSN： 1477-0970
Protective Effects of Sustained Unoprostone Release Device in Rhodopsin Pro347Leu Transgenic Rabbits

Nobuhiro Nagai, Yasuko Izumida, Hirokazu Kai, Matsuhiko Nishizawa, Aya Katsuyama, Shinji Yamada, Toru Nakazawa, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toshiaki Abe

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Inhibition of Sp1 signaling promotes retinal ganglion cell death via apoptotic and necrotic pathways in a model of glaucoma

Kota Sato, Yukihiro Shiga, Kazuko Omodaka, Shigeto Maekawa, Namie Murayama, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma study 1: Analysis of visual field defect in preperimetric glaucoma

Naoko Aizawa, Yukihiro Shiga, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Glaucoma

Naoki Kiyota, Yukihiro Shiga, Marika Sato, Shigeto Maekwa, Kazuko Omodaka, Kazuichi Maruyama, Hidetoshi Takahashi, Hiroshi Kunikata, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Imaging of scar tissue in the filtering bleb by anterior-segment polarization-sensitive OCT

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Kazuko Omodaka, Yu Yokoyama, Noriko Himori, Shiho Kunimatsu-Sanuki, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Lamina cribrosa thinning in glaucoma and associated factors

Kazuko Omodaka, Seri Takahashi, Akiko Matsumoto, Shigeto Maekawa, Shiori Suzuki, Yukihiro Shiga, Tsutomu Kikawa, Kazuichi Maruyama, Masahiro Akiba, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
The structure/function relationship between wide-scan binocular OCT images and the binocular visual field in glaucoma patients

Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Culture of retinal ganglion cells (RGC) purified from 3D retinal organoids differentiated from human induced pluripotent stem (iPS) cells

Wataru Kobayashi, Akishi Onishi, Yuji Takihara, Masaru Inatani, Toru Nakazawa, Masayo Takahashi

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma study 2: The relationship between optic nerve head blood flow and visual field progression in preperimetric glaucoma

Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
正常眼圧緑内障患者における酸化ストレスマーカーと視神経乳頭循環

檜森紀子, 國方彦志, 志賀由己浩, 面高宗子, 中澤徹

日本酸化ストレス学会学術集会プログラム・抄録集　69th　156　2016/08/30
緑内障患者における酸化ストレスと視野

國方彦志, 檜森紀子, 川崎良, 志賀由己浩, 面高宗子, 高木愛理, 中澤徹

日本酸化ストレス学会学術集会プログラム・抄録集　69th　155　2016/08/30
「緑内障診療データの管理と共通化の現状とデータ共通化に向けての取り組み」pp540-547．日本眼科学会雑誌第120巻8号.2016

NAKAZAWA Toru

120　(8)　540-547　2016/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ROCK阻害薬と神経保護効果 (特集眼疾患におけるROCK阻害薬の可能性)

丸山和一, 中澤徹

医薬ジャーナル　52　(6)　121-125　2016/06
Publisher: 医薬ジャーナル社
ISSN： 0287-4741
エイジングからみた緑内障 (特集エイジングと加齢眼疾患)

檜森紀子, 中澤徹

眼科　58　(6)　627-633　2016/06
Publisher: 金原出版
ISSN： 0016-4488
【眼疾患におけるROCK阻害薬の可能性】ROCK阻害薬と神経保護効果

丸山和一, 中澤徹

医薬ジャーナル　52　(6)　1505-1509　2016/06
Publisher: (株)医薬ジャーナル社
ISSN： 0287-4741
ROCK阻害薬と神経保護効果 pp,121-125「医薬ジャーナル」Vol52,No,6 2016/06/01

NAKAZAWA Toru

2016/06
感覚器障害ゼロを目指してpp41-42 ART,Ver.05 東北大学院医学研究科所属創生応用医学研究センター 2016/05

NAKAZAWA Toru

2016/05
ステレオ眼底カメラで得られたパラメータによる視神経乳頭形状自動分類の妥当性

谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

眼科臨床紀要　9　(4)　389-389　2016/04
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
眼科医はじめの5年・10年にしておくべきこと

石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児

Retina Medicine　5　(1)　1-7　2016/04
Publisher: (株)先端医学社
ISSN： 2187-2384
連載第五回日本人のヒット論文ー本音で語る苦労話－〈著者インタビュー〉pp67－74,Retina Medicine. Vol.5 no.1 2016/4/1

NAKAZAWA Toru

2016/04
濾過胞観察におけるOCT減衰係数画像の有用性の検討

國分太貴, 國分太貴, 津田聡, 山成正宏, 國方彦志, 面高宗子, 横山悠, 檜森紀子, 國松志保, 丸山和一, 中澤徹

日本眼科学会雑誌　120　(臨増)　169-169　2016/03/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障眼における酸素吸入時の視神経乳頭血流動態

清田直樹, 志賀由己浩, 鈴木詩織, 佐藤茉莉華, 高田菜生子, 前川重人, 面高宗子, 丸山和一, 高橋秀肇, 國方彦志, 中澤徹

日本眼科学会雑誌　120　(臨増)　166-166　2016/03/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者における酸化ストレスと抗酸化力

檜森紀子, 志賀由己浩, 面高宗子, 國方彦志, 高木愛梨, 川崎良, 中澤徹

日本眼科学会雑誌　120　(臨増)　168-168　2016/03/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
黄斑円孔に対するinverted ILM flap法の術後成績とOCT所見

橋本和軌, 國方彦志, 安田正幸, 相澤奈帆子, 伊藤梓, 中澤徹

日本眼科学会雑誌　120　(臨増)　281-281　2016/03/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
極早期緑内障病態研究極早期緑内障眼での視野障害発症部位の検討

相澤奈帆子, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　120　(臨増)　163-163　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
低眼灌流圧を有する正常眼圧緑内障眼の視神経乳頭血流と構造変化

米谷優輝子, 志賀由己浩, 鎌田泰彰, 面高宗子, 横山悠, 津田聡, 高橋秀肇, 中澤徹

日本眼科学会雑誌　120　(臨増)　166-166　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
極早期緑内障病態研究極早期緑内障眼における視神経乳頭血流の視野進行への関与

志賀由己浩, 相澤奈帆子, 津田聡, 面高宗子, 横山悠, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　120　(臨増)　166-166　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
眼悪性黒色腫におけるポドプラニンの発現

丸山和一, 臼井嘉彦, 加藤幸成, 永井毅, 長尾俊孝, 後藤浩, 中澤徹

日本眼科学会雑誌　120　(臨増)　203-203　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
早期糖尿病網膜症患者における脈絡膜厚と運動神経伝導速度の関係

伊藤梓, 國方彦志, 安田正幸, 澤田正二郎, 近藤敬一, 佐竹千尋, 橋本和軌, 相澤奈帆子, 片桐秀樹, 中澤徹

日本眼科学会雑誌　120　(臨増)　217-217　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ラット視神経挫滅モデルの網膜トランスクリプトーム解析

安田正幸, 西口康二, 面高宗子, 田中佑治, 中澤徹

日本眼科学会雑誌　120　(臨増)　246-246　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
角膜疾患に対する未来医療

西田幸二, 前田直之, 辻川元一, 川崎諭, 高静花, 橋田徳康, 相馬剛至, 大家義則, 馬場耕一, 林竜平, 藤本久貴, 佐々本弦, 原進, 高柳泰, 三田村勇人, 浅尾和伸, 渡辺真矢, 木村恵利香, 安藤覚, 石川幸, 香取良祐, 野村直樹, 荒木さおり, 市川達也, 不二門尚, 瓶井資弘, 松下賢治, 坂口裕和, 佐藤茂, 森本壮, 臼井審一, 三木篤也, 西田健太郎, 佐柳香織, 佐藤達彦, 福嶋葉子, 大浦嘉仁, 原千佳子, 若林卓, 永原裕紀子, 白木暢彦, 松原聖子, 岡野光夫, 大和雅之, 山中伸弥, 澤芳樹, 新谷歩, 嶋澤るみ子, 中谷明弘, 今井敦子, 横倉俊二, 菊地未来, 櫻井美晴, 布施昇, 中澤徹, 榛村重人, 坪田一男, 畠賢一郎, 井家益和, 林成晃, 小澤洋介, 林研一

日本眼科学会雑誌　120　(3)　226-244　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障の早期発見に威力を発揮する、世界初の装置を開発 p15 JST進行促進プログラム成果事例集2016 第2巻国立研究開発法人科学技術振興機構JST 復興促進センター 2016/3

NAKAZAWA Toru

2016/03
正常眼圧緑内障 p159 眼科疾患最新の治療 2016－2018 南工堂 2016/3/5

NAKAZAWA Toru

2016/03
網膜下線維瘢痕化におけるインターロイキン(IL)-6の関与

長谷川英一, 佐藤孝太, 武田篤信, 大島裕司, 中澤徹, JO Young-Joon, 園田康平

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　53rd-50th-59th-5th　2016
涙嚢鼻腔吻合術鼻外法の術前CTにおけるagger nasi cellの検討

目黒泰彦, 後藤聡, 横倉俊二, 高橋麻衣, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　53rd-50th-59th-5th　2016
遺伝性網膜変性症における血清抗リカバリン抗体の検出

西口康二, 藤田幸輔, 中澤徹, 中澤徹, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　55th　2016
In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

5　(1)　67-74　2016
Publisher: 先端医学社
ISSN： 2187-2384
後期緑内障のドライビングシミュレータ

宇田川さち子, 大久保真司, 国松志保, 青木由紀, 岩瀬愛子, 福地健郎, 小野浩, 中澤徹, 杉山和久, 新家眞

眼科臨床紀要　9　(1)　77-77　2016/01
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
網膜色素変性モデルウサギに対するウノプロストン徐放デバイスの網膜保護効果

永井展裕, 泉田泰子, 梶弘和, 勝山綾, 中澤徹, 近藤峰生, 寺崎浩子, 西澤松彦, 山田慎二, 眞島行彦, 阿部俊明

日本眼科学会雑誌　120　2016

ISSN： 0029-0203
後眼部局所持続投与を指向した薬物徐放デバイスの開発

永井展裕, 梶弘和, 泉田泰子, 山田慎二, 中澤徹, 西澤松彦, 眞島行彦, 阿部俊明

日本DDS学会学術集会プログラム予稿集　32nd　2016
PPGを含めた緑内障性障害におけるEstimated RGC countの有用性

山崎舞, 面高宗子, 吉田みなみ, 相澤奈帆子, 國方彦志, 中澤徹

日本緑内障学会抄録集　27th　2016
緑内障性中心障害における実用視力の検討

佐藤はる香, 大内順子, 面高宗子, 大里哲也, 國方彦志, 中澤徹

日本緑内障学会抄録集　27th　80　2016
全身性エリテマトーデス患者における眼血流解析

伊藤梓, 國方彦志, 安田正幸, 相澤奈帆子, 石井智徳, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　55th　75　2016
緑内障病期別にみた視神経乳頭血流解析

相澤奈帆子, 國方彦志, 中澤徹

日本眼循環学会講演抄録集　33rd　73　2016
極早期緑内障病態研究 1:極早期緑内障における視野進行と視神経乳頭血流の関係性

相澤奈帆子, 國方彦志, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　27th　162　2016
レーザースペックルフローグラフィーと光干渉断層計アンギオグラフィーの血流パラメータの関係性

清田直樹, 國方彦志, 志賀由己浩, 面高宗子, 中澤徹

日本緑内障学会抄録集　27th　163　2016
緑内障患者における睡眠時無呼吸症候群と酸化ストレスとの関連

山田絵里香, 檜森紀子, 山崎舞, 面高宗子, 國方彦志, 長澤美穂, 小川浩正, 一ノ瀬和, 中澤徹

日本緑内障学会抄録集　27th　202　2016
緑内障患者の前房水中サイトカインのプロファイルの検討

國分太貴, 津田聡, 國方彦志, 横山悠, 面高宗子, 檜森紀子, 国松志保, 丸山和一, 中澤徹

日本緑内障学会抄録集　27th　71　2016
In vivoイメージングによるNMDA障害後の網膜神経節細胞死の評価

伊藤梓, 國方彦志, 前川重人, 津田聡, 佐藤孝太, 浅井信晴, 中澤徹

日本緑内障学会抄録集　27th　89　2016
壊死性強膜炎治療中に発症したP.acnesとPaecilomyces sp.による眼内炎の一例

吉田真彰, 横倉俊二, 丸山和一, 高田菜生子, 國方彦志, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　53rd-50th-59th-5th　68　2016
MRIにおける眼窩内視神経断面積の緑内障性変化

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本緑内障学会抄録集　27th　96　2016
MRIにおける脳一次視覚野の緑内障性変化

面高宗子, 福田麻奈, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本緑内障学会抄録集　27th　96　2016
『Retina Medicine』座談会眼科医じめの５年・１０年にしておくべきことｐｐ１-７,

NAKAZAWA Toru

5　(1)　1-7　2016
Publisher: 先端医学社
ISSN： 2187-2384
パスウェイ特異的プロモーターを用いた網膜神経節細胞ストレス応答のin vivoイメージング

藤田幸輔, 西口康二, 横山悠, 富山優介, 津田聡, 安田正幸, 中澤徹

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[4T18p-11(3P1293)]　2015/12
Publisher: (公社)日本生化学会
若手眼科医のオーナーシップ

NAKAZAWA Toru

日本眼科学会雑誌　119　(12)　2015/12
レーザースペックルによる網膜静脈分枝閉塞症でのラニビズマブ投与前後の眼血流変化

新田文彦, 國方彦志, 相澤奈帆子, 伊藤梓, 阿部俊明, 中澤徹

眼科臨床紀要　8　(11)　822-822　2015/11
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
黄斑剥離を伴う裂孔原性網膜剥離における視力予後予測因子

鈴木哲章, 國方彦志, 相澤奈帆子, 阿部俊明, 中澤徹

眼科臨床紀要　8　(10)　765-765　2015/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
裂孔原性網膜剥離眼の視神経乳頭血流解析からみた視力予後因子

相澤奈帆子, 國方彦志, 新田文彦, 鈴木哲章, 油井理恵子, 中澤徹

眼科臨床紀要　8　(10)　764-764　2015/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
黄斑部の評価 Medical View Point Vol36 No10 20151010

NAKAZAWA Toru

2015/10
WNT7B 多型は近視進行の新しいメカニズムを示唆する〈著者インタビュー〉Retina Medicine Vol4 no.2 2015/10

NAKAZAWA Toru

2015/10
見える喜びいつまでも～知っておきたい緑内障の最新情報～宮城の医療と健康2015－2016 2015/10

NAKAZAWA Toru

2015/10
緑内障の神経保護治療の変遷

檜森紀子, 中澤徹

眼科　57　(10)　1235-1242　2015/09
Publisher: 金原出版
ISSN： 0016-4488
ステレオ眼底カメラにより解析した健常眼の視神経乳頭形状パラメーター

片井麻貴, 谷戸正樹, 北岡康史, 横山悠, 新田耕治, 面高宗子, 菊川泰士, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 大久保真司, 松本長太, 杉山和久, 中澤徹

日本緑内障学会抄録集　26回　138-138　2015/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより計測した視神経乳頭形状パラメーターを用いた乳頭形状分類の妥当性の検証

谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　26回　138-138　2015/09
Publisher: 日本緑内障学会
ステレオ眼底写真による緑内障性視神経乳頭形状分類と関連する視野障害部位

横山悠, 谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　26回　138-138　2015/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより解析した視神経乳頭形状パラメーターの緑内障眼と正常眼との比較

北岡康史, 谷戸正樹, 横山悠, 新田耕治, 片井麻貴, 面高宗子, 菊川泰士, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 大久保真司, 松本長太, 杉山和久, 中澤徹

日本緑内障学会抄録集　26回　139-139　2015/09
Publisher: 日本緑内障学会
緑内障診療データの管理と共通化の現状とデータ共通化に向けての取り組み

柏木賢治, 吉冨健志, 岩瀬愛子, 杉山和久, 川瀬和秀, 中村誠, 相原一, 中澤徹, 福地健郎, 稲谷大, 新家眞

日本緑内障学会抄録集　26回　126-126　2015/09
Publisher: 日本緑内障学会
緑内障性視神経症の臨床診断、視神経乳頭陥凹の形状「視神経乳頭・視野でみる緑内障確定診断」

NAKAZAWA Toru

メジカルビュー社　2015/09
緑内障に対する眼圧以外のアプローチ MedicalView Point Vol36 Suppl. 9 2015/9/25

NAKAZAWA Toru

2015/09
Trabectome手術 (特集流出路再建術の適応と比較)

高橋秀肇, 中澤徹

Oculista = オクリスタ　(27)　31-38　2015/06
Publisher: 全日本病院出版会
ISSN： 2187-5855
Effect of a PG analogue on optic nerve head blood flow in eyes with preperimetric glaucoma

Naoki Kiyota, Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device

Nobuhiro Nagai, Yasuko Izumida, Eri Koyanagi, Hirokazu Kaji, Matsuhiko Nishizawa, Takahito Imagawa, Akiko Morikawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Ranibizumab Delivery Device Using Polyethyleneglycol Dimethacrylates

Toshiaki Abe, Aya Katsuyama, Hideyuki Onami, Toru Nakazawa, Nobuhiro Nagai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma pathophysiological study part1:Twelve-month results of topical prostaglandin analogues

Naoko Aizawa, Hiroshi Kunikata, Satoru Tsuda, Yukihiro Shiga, Yukiko Maiya, Naoki Kiyota, Kazuko Omodaka, Yu Yokoyama, Morin Ryu, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Role of GDNF receptor-related genes to axonal damage-induced retinal ganglion cell death and regeneration

Kazuko Omodaka, Takuji Kurimoto, Orie Nakamura, Kota Sato, Masayuki Yasuda, Noriko Himori, Yu Yokoyama, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma pathophysiological study part4: Significant reduction in optic nerve head blood flow

Yukiko Maiya, Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
LSFG-measured reduction of temporal optic disc circulation in ADOA patients

Maki Inoue, Noriko Himori, Takayuki Takeshita, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Kazuichi Maruyama, Koji Nishiguchi, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma pathophysiological study part3: Association between EDNRA genotype and the effect of a prostaglandin analogue on ocular blood flow

Yukihiro Shiga, Nobuo Fuse, Kota Sato, Naoko Aizawa, Satoru Tsuda, Masae Kimura, Koji Nishiguchi, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Glaucoma as primary cause of blindness in a Japanese adult population

253　(2)　166-170　2015/04/11
Publisher: 医歯薬出版
ISSN： 0039-2359
網膜研究・診療の未来予想図

石田晋, 小沢洋子, 近藤峰生, 中澤徹, 平見恭彦, 藤波芳, 安川力, 山城健児

Retina Medicine　4　(1)　1-9　2015/04
Publisher: (株)先端医学社
ISSN： 2187-2384
マウス視神経挫滅モデルにおけるScotopic Threshold Response早期変化

雪田昌克, 町田繁樹, 西口康二, 津田聡, 田中佑治, 横山悠, 安田正幸, 丸山和一, 中澤徹

眼科臨床紀要　8　(4)　251-251　2015/04
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
極早期緑内障病態研究 1:プロスタグランジン関連薬による12カ月長期治療成績

相澤奈帆子, 國方彦志, 津田聡, 志賀由己浩, 清田直樹, 米谷優輝子, 面高宗子, 横山悠, 劉孟林, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　119　(臨増)　230-230　2015/03/18
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
極早期緑内障病態研究プラスタグランジン関連薬の乳頭血流改善効果に関する検討

清田直樹, 志賀由己浩, 相澤奈帆子, 津田聡, 横山悠, 面高宗子, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　119　(臨増)　231-231　2015/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
極早期緑内障病態研究極早期緑内障眼における視神経乳頭血流動態に関する検討

米谷優輝子, 志賀由己浩, 相澤奈帆子, 津田聡, 横山悠, 面高宗子, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　119　(臨増)　235-235　2015/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
眼疾患メカニズムの新しい理解失明ゼロを目指して

中澤徹, 國方彦志, 横倉俊二, 丸山和一, 西口康二, 高橋秀肇, 国松志保, 劉孟林, 檜森紀子, 田中佑治, 新田文彦, 森藤暁, 藤田幸輔, 中村織江, 面高宗子, 安田正幸, 横山悠, 相澤奈帆子, 山本耕太郎, 雪田昌克, 津田聡, 志賀由己浩, 前川重人, 國分太貴, 今野瑛之, 高橋麻衣, 萱場寛子, 橋本清香, 佐藤茉莉華, 矢花武史, 高田菜生子, 高橋世理, 鎌田泰彰

日本眼科学会雑誌　119　(3)　168-194　2015/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
RNAシークエンスを用いたラット視神経軸索障害モデルの網膜トランスクリプトーム解析

安田正幸, 西口康二, 面高宗子, 田中佑治, 中澤徹

日本眼科学会雑誌　119　(臨増)　242-242　2015/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
パスウェイ特異的レポーターによる網膜神経節細胞ストレス応答のin vivoイメージング

西口康二, 藤田幸輔, 藤井裕介, 山本耕太郎, 津田聡, 安田正幸, 中澤徹

日本眼科学会雑誌　119　(臨増)　244-244　2015/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
早期糖尿病網膜症患者における皮膚自発蛍光と眼血流の関係

橋本和軌, 國方彦志, 安田正幸, 伊藤梓, 相澤奈帆子, 西口康二, 近藤敬一, 澤田正二郎, 佐竹千尋, 中澤徹

日本眼科学会雑誌　119　(臨増)　254-254　2015/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
漢方薬の血圧、脈拍、眼底血流に対する影響の検討

高山真, 沼田健裕, 志賀由己浩, 田中淳一, 黒田仁, 松向寺孝臣, 阿部倫明, 金村政輝, 中澤徹, 石井正

日本内科学会雑誌　104　(Suppl.)　286-286　2015/02
Publisher: (一社)日本内科学会
ISSN： 0021-5384

eISSN： 1883-2083
マウス視神経挫滅モデルにおけるscotopic threshold response早期変化

雪田昌克, 町田繁樹, 西口康二, 津田聡, 横山悠, 安田正幸, 丸山和一, 中澤徹

日本眼科学会雑誌　119　(2)　80-80　2015/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
アカデミアにおける細胞プロセッシングセンター活用の新しいスタイルの模索

沖田ひとみ, 伊藤貴子, 吉田まなみ, 堺香名子, 横倉俊二, 高柳泰, 大家義則, 西田幸二, 中澤徹, 張替秀郎, 後藤昌史, 下川宏明

再生医療　14　350　2015/02/01

ISSN： 1347-7919
voxel based morphometry(VBM)を用いた緑内障における脳視路変性の検討

舘脇康子, 村田隆紀, 麦倉俊司, 高橋昭喜, 瀧靖之, 関口敦, 面高宗子, 中澤徹

Japanese Journal of Radiology　33　(Suppl.)　9-9　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
緑内障モデル動物における神経節細胞死とネクロプトーシス経路の関与

佐藤孝太, 志賀由己浩, 面高宗子, 前川重人, 村山奈美枝, 中澤徹

日本緑内障学会抄録集　26th　2015
マウス視神経挫滅モデルの網膜神経節細胞障害におけるECEL1の関与

志賀由己浩, 佐藤孝太, 前川重人, 面高宗子, 丸山和一, 西口康二, 中澤徹

日本緑内障学会抄録集　26th　2015
網膜色素変性治療をめざした経強膜ウノプロストン徐放法の開発に関する研究動物モデルの評価と疾患レジストリー構築準備

中澤徹

網膜色素変性治療をめざした経強膜ウノプロストン徐放法の開発に関する研究平成26年度総括研究報告書　2015
PROGRAM FOR CONTINUING PROFESSIONAL EDUCATION IN OPHTHALMOLOGY(A Review 61)Neuroprotective Treatment for Glaucoma

119　(1)　31-41　2015/01
Publisher: 日本眼科学会
ISSN： 0029-0203
上方視神経低形成(SSOH)とはどのような病態ですか? (今さら聞けないQ&A(第7回))

相澤奈帆子, 中澤徹

Retina medicine : journal of retina medeicine : 網膜・硝子体領域を中心とした医学情報誌　4　(2)　190-191,101　2015
Publisher: 先端医学社
ISSN： 2187-2384
Identification of myopia-asso-ciate WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

4　(2)　173-180,100　2015
Publisher: 先端医学社
ISSN： 2187-2384
緑内障の未来予想図 (特集網膜分野の未来予想図)

檜森紀子, 中澤徹

Retina medicine : journal of retina medeicine : 網膜・硝子体領域を中心とした医学情報誌　4　(1)　25-29,10　2015
Publisher: 先端医学社
ISSN： 2187-2384
2011-2013年に霊長類医科学研究センターで撮影されたサル1443頭の眼底写真の解析

藤井裕介, 西口康二, 西口康二, 古川敏紀, 小野文子, 下澤律浩, 東郷睦, 鈴木通弘, 中澤徹, 中澤徹

日本眼科学会雑誌　119　2015

ISSN： 0029-0203
経強膜持続投与デバイスの眼毒性評価

永井展裕, 泉田泰子, 小柳恵理, 梶弘和, 西澤松彦, 中澤徹, 眞島行彦, 阿部俊明

日本眼科学会雑誌　119　2015

ISSN： 0029-0203
ウノプロストン徐放デバイスによる網膜内局所持続投与の評価

永井展裕, 泉田泰子, 梶弘和, 本山玲美, 西澤松彦, 中澤徹, 眞島行彦, 阿部俊明

日本DDS学会学術集会プログラム予稿集　31st　2015
Comparison of outcome of subtenon and intravitreal injection of triamcinolone acetonide for diabetic macular edema

今留尚人, 國方彦志, 浅野俊一郎, 今野瑛之, 泉武, 中澤徹

臨床眼科　69　(5)　2015

ISSN： 0370-5579
免疫抑制療法併用毛様体扁平部型バルベルトシャント手術について

丸山和一, 針谷威寛, 国松志保, 横倉俊二, 國方彦志, 中澤徹

日本緑内障学会抄録集　26th　136-136　2015
Publisher: 日本緑内障学会
緑内障眼における色視力測定の検討

大内順子, 面高宗子, 佐藤はる香, 大里哲也, 佐藤裕之, 伊藤梓, 相澤奈帆子, 田中芳樹, 國方彦志, 市川一夫, 中澤徹

日本緑内障学会抄録集　26th　108-108　2015
Publisher: 日本緑内障学会
偏光OCTによる濾過胞内の複屈折の定量評価と術後成績の関係

國分太貴, 國分太貴, 國方彦志, 山成正宏, 面高宗子, 檜森紀子, 国松志保, 劉孟林, 高橋秀肇, 丸山和一, 中澤徹

日本緑内障学会抄録集　26th　142-142　2015
Publisher: 日本緑内障学会
極早期緑内障患者に対するタフルプロスト点眼液による治療成績と視野障害発症症例の患者背景

相澤奈帆子, 國方彦志, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 劉孟林, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　26th　123-123　2015
Publisher: 日本緑内障学会
緑内障の診断におけるEstimated RGC countの有用性

山崎舞, 面高宗子, 相澤奈帆子, 國方彦志, 中澤徹

日本緑内障学会抄録集　26th　106　2015
正常眼圧緑内障患者における酸化ストレスと視神経乳頭循環との関連

檜森紀子, 志賀由己浩, 面高宗子, 相澤奈帆子, 丸山和一, 國方彦志, 中澤徹

日本緑内障学会抄録集　26th　151-151　2015
Publisher: 日本緑内障学会
前眼部偏光OCTによる濾過胞瘢痕組織の複屈折イメージングと定量解析

山成正宏, 津田聡, 國分太貴, 檜森紀子, 國松志保, 高橋秀肇, 丸山和一, 國方彦志, 中澤徹

日本眼光学学会総会プログラム・抄録集　51st　61　2015
妊娠経過中の視神経乳頭血流解析

相澤奈帆子, 佐藤孝洋, 國方彦志, 萱場寛子, 倉片三千代, 杉山隆, 菅原準一, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　54th　87　2015
糖尿病網膜症における強膜自発蛍光測定の有用性の検討

安田正幸, 國方彦志, 相澤奈帆子, 田中佑治, 永富良一, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　54th　85　2015
緑内障手術成績を向上させるために

NAKAZAWA Toru

眼薬理　29　(1)　5-14　2015

ISSN： 0914-1405
白紙文雄：Leber 遺伝性視神経認証認定基準「日本眼科学会雑誌」

NAKAZAWA Toru

119　(5)　339-346　2015
眼圧が下降しても視野障害進行判定が重要銀海 No,233

NAKAZAWA Toru

2015
上方視神経低形成（SSOH）はどのような病態ですか？ Retinal Medicine Vol4 No.2

NAKAZAWA Toru

2015
緑内障診断の落とし穴（全身疾患を含む）眼科臨床実践講座Q&A集 2015

NAKAZAWA Toru

2015
緑内障 (特集内科医に求められる他科の知識 : 専門家が伝えるDo-Don't) -- (眼科)

劉孟林, 中澤徹

内科　114　(6)　1032-1035　2014/12
Publisher: 南江堂
ISSN： 0022-1961
サルコイドーシス患者の硝子体液サンプルを用いた診断有用性について

丸山和一, 稲葉亨, 國方彦志, 望月學, 中澤徹

日本サルコイドーシス/肉芽腫性疾患学会雑誌　34　(1)　49-2-49-2　2014/10/15
Publisher: 日本サルコイドーシス/肉芽腫性疾患学会
DOI： 10.7878/jjsogd.34.49-2 　

ISSN： 1883-1273
レーザースペックルフローグラフィー

相澤奈帆子, 中澤徹

眼科　56　(11)　1341-1347　2014/10
Publisher: 金原出版
ISSN： 0016-4488
原発性アルドステロン症における眼底血流評価の臨床的意義について

工藤正孝, 國方彦志, 相澤奈帆子, 麦倉俊司, 新田文彦, 小野美澄, 岩倉芳倫, 尾股慧, 森本玲, 清治和将, 高瀬圭, 高橋秀肇, 中澤徹, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　37回　368-368　2014/10
Publisher: (NPO)日本高血圧学会
Changes in dry eye after the Great East Japan Earthquake

浅野俊一郎, 久保田久世, 國方彦志, 今留尚人, 中澤徹

臨床眼科　68　(9)　1285-1289　2014/09/15
Publisher: 医学書院
DOI： 10.11477/mf.1410105377 　

ISSN： 0370-5579
極早期緑内障病態研究研究デザインと患者背景

劉孟林, 横山悠, 相澤奈帆子, 面高宗子, 津田聡, 志賀由己浩, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　25回　86-86　2014/09
Publisher: 日本緑内障学会
極早期緑内障病態研究極早期緑内障眼における遺伝子多型とプロスタグランジン関連薬による乳頭循環反応

志賀由己浩, 布施昇男, 清水愛, 木村雅恵, 津田聡, 相澤奈帆子, 横山悠, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　25回　87-87　2014/09
Publisher: 日本緑内障学会
局所性障害に対する乳頭形状別の血流関与についての検討

米谷優輝子, 高橋秀肇, 志賀由己浩, 面高宗子, 津田聡, 横山悠, 国松志保, 中澤徹

日本緑内障学会抄録集　25回　87-87　2014/09
Publisher: 日本緑内障学会
正常眼圧緑内障患者における神経走行を考慮したOCT黄斑セクターの設定

井上真希, 面高宗子, 横山悠, 志賀由己浩, 津田聡, 檜森紀子, 丸山和一, 中澤徹

日本緑内障学会抄録集　25回　101-101　2014/09
Publisher: 日本緑内障学会
視野進行における局所性障害の評価の検討

高橋秀肇, 志賀由己浩, 面高宗子, 津田聡, 横山悠, 国松志保, 中澤徹

日本緑内障学会抄録集　25回　105-105　2014/09
Publisher: 日本緑内障学会
LSFGを用いた正常人における酸素吸入時の視神経乳頭血流動態評価

佐藤茉莉華, 志賀由己浩, 丸山和一, 高山真, 面高宗子, 檜森紀子, 國方彦志, 中澤徹

日本緑内障学会抄録集　25回　86-86　2014/09
Publisher: 日本緑内障学会
12方向網膜視神経線維層厚と静的自動視野計検査点との相関

鈴木哲章, 横山悠, 国松志保, 今野瑛之, 安田正幸, 西口康二, 中澤徹

日本緑内障学会抄録集　25回　96-96　2014/09
Publisher: 日本緑内障学会
In vivo imagingによる視神経挫滅後の網膜神経節細胞死の評価

津田聡, 田中佑治, 國方彦志, 横山悠, 安田正幸, 中澤徹

日本緑内障学会抄録集　25回　115-115　2014/09
Publisher: 日本緑内障学会
抗MOG抗体陽性視神経炎の臨床的特徴の解析

赤石哲也, 佐藤ダグラス, 中島一郎, 竹下孝之, 高橋利幸, 三須建郎, 中澤徹, 藤原一男, 青木正志

神経免疫学　19　(1)　112-112　2014/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
マウス軸索障害に対するheme oxygenase-1の内在性神経保護作用

檜森紀子, 丸山和一, 山本耕太郎, 安田正幸, 劉孟林, 面高宗子, 志賀由己浩, 中澤徹

日本抗加齢医学会総会プログラム・抄録集　14回　324-324　2014/06
Publisher: (一社)日本抗加齢医学会
Preface

Toru Nakazawa, Yasushi Kitaoka, Takayuki Harada

Neuroprotection and Neuroregeneration for Retinal Diseases　v-vii　2014/05/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54965-9 　
Neuroprotection and neuroregeneration for retinal diseases

Toru Nakazawa, Yasushi Kitaoka, Takayuki Harada

Neuroprotection and Neuroregeneration for Retinal Diseases　1-356　2014/05/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54965-9 　
Glaucoma and Anti-Aging Medicines

31　(4)　517-522　2014/04
Publisher: メディカル葵出版
ISSN： 0910-1810
英語で発表しよう、留学に行こう

石田晋, 小沢洋子, 近藤峰生, 園田康平, 中澤徹, 安川力, 山城健児

Retina Medicine　3　(1)　1-7　2014/04
Publisher: (株)先端医学社
ISSN： 2187-2384
レーザースペックル眼底血流検査による血流動態が緑内障に与える影響

高橋秀肇, 志賀由己浩, 面高宗子, 高橋麻衣, 相澤奈帆子, 國方彦志, 中澤徹

日本眼科学会雑誌　118　(臨増)　160-160　2014/03/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
【先端的眼科治療(角膜と網膜の新しい治療法)】緑内障における神経保護治療

津田聡, 中澤徹

Medical Science Digest　40　(3)　120-123　2014/03
Publisher: (株)ニュー・サイエンス社
ISSN： 1347-4340
眼疾患と遺伝子緑内障のゲノム解析次世代医療・個別化医療に向けて

布施昇男, 清水愛, 木村雅恵, 高野良真, 石棟, 宮澤晃子, 国松志保, 劉孟林, 渡邉亮, 安田正幸, 横山悠, 檜森紀子, 津田聡, 山本耕太郎, 中澤徹, 安田純, 勝岡史城, 小島要, 成相直樹, 松本光代, 元池育子, 長崎正朗, 木下賢吾, 五十嵐和彦, 山本雅之, 新堀哲也, 青木洋子, 松原洋一, 舟山亮, 長嶋剛史, 中山啓子, 眞島行彦, 船山智代, 田中光一, 原田高幸, 阿部春樹, 福地健郎, 安田典子, 出田秀尚, 鄭暁東, 白石敦, 大橋裕一, 石田誠夫, 原岳, 金森章泰, 山田裕子, 中村誠, 酒井寛, Richards Julia E

日本眼科学会雑誌　118　(3)　216-240　2014/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者における視神経・視放線の拡散テンソル解析の試み

村田隆紀, 佐藤志帆, 舘脇康子, 麦倉俊司, 高橋昭喜, 面高宗子, 土井洋, 中澤徹, 大友孝昭

Jpn J Radiol　32　(Supplement)　9-9　2014/02/25
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
Registration Algorithm of Fundus Oculi for 3-D Optical Coherence Tomography Images

TOGASHI Kyosuke, SAKAMOTO Miki, TAKEUCHI Gaku, AKIBA Masahiro, YABANA Takeshi, OMODAKA Kazuko, RYU Morin, TSUDA Satoru, YOKOYAMA Yu, FUKUMA Yasufumi, NAKAZAWA Toru, YUASA Tetsuya

IEICE technical report.　113　(410)　133-137　2014/01/26
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

More details Close

Recently, retinal nerve fiber layer (RNFL) thickness measurement from retinal optical coherence tomography (OCT) images has been widely used as an important clinical index to indicate a glaucoma progression. While a long-term follow-up of RNFL thickness is effective tool for glaucoma diagnosis, a precise registration is indispensable for OCT images acquired at different date. In this study, we propose a registration algorithm to correct random shifts occurring whenever imaging based on a projection image generated from the 3-D OCT retinal images. For speeding-up, the algorithm was implemented by processing in Fourier space based on properties of Fourier transform with rotation and translation, which is referred to as phase-only correlation method. For the stable detection of shift, several preprocessing to raw data, such as background correction to homogenize different imaging conditions, zero-padding to resize the registration image from a rectangular to a square image size, and Hanning-windowing to suppress unnecessary higher frequency-components, were carefully applied before registration. We demonstrated the effectiveness of the proposed method using an actual retina image (512×885×64) of a healthy volunteer acquired by 3-D OCT-2000 manufactured by TOPCON, Japan. The measurement was repeated 10 times, and the degree of agreement in RNFL thickness measured was evaluated with root mean square (RMS). The average RMS before and after preregistration were 4.7±1.6 and 2.6±0.3 μm, respectively. From this result, it can be concluded that the proposed method improved the precision approximately twofold. In addition, the processing time was approximately 0.3 s for a single data set, which will fall inside a permissible range of clinical use. Proposed technique may become a useful tool for glaucoma diagnosis.
ビルベリーアントシアニンはERシャペロン調節を介して網膜神経節細胞死を抑制する

中村織江, 檜森紀子, 面高宗子, 森藤暁, 中澤徹, 中澤徹

日本生化学会大会(Web)　87th　2014
新規薬剤の生体内スクリーニングシステムの確立と網膜保護用デバイスの開発に関する研究重症眼疾患と神経保護治療

中澤徹

新規薬剤の生体内スクリーニングシステムの確立と網膜保護用デバイスの開発に関する研究平成25年度総括・分担研究報告書　2014
A case of Mooren ulcer with corneal perforation following cyclophotocoagulation for glaucoma

多田麻子, 国松志保, 横倉俊二, 土井洋, 中澤徹

臨床眼科　68　(8)　2014

ISSN： 0370-5579
Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

3　(2)　169-177　2014
Publisher: 先端医学社
ISSN： 2187-2384
緑内障関連遺伝子研究班の活動報告

柏木賢治, 間渕文彦, 中澤徹, 相原一, 岩田岳, 新家眞

日本緑内障学会抄録集　25th　2014
経強膜持続投与デバイスによる網膜保護の可能性

永井展裕, 梶弘和, 西澤松彦, 中澤徹, 阿部俊明

日本眼科学会雑誌　118　2014

ISSN： 0029-0203
ウノプロストン徐放デバイスの強膜上投与による眼内薬物動態と埋植毒性評価

永井展裕, 泉田泰子, 梶弘和, 西澤松彦, 中澤徹, 眞島行彦, 阿部俊明

日本バイオマテリアル学会大会予稿集　36th　2014
光硬化性樹脂を利用した網膜ドラッグデリバリーシステムの開発

永井展裕, 梶弘和, 西澤松彦, 中澤徹, 真島行彦, 阿部俊明

日本生物工学会大会講演要旨集　66th　2014
2D14 Eyeball Deformation Characteristics during Air Jet Application Before and After the Vitreous Surgery

UEMURA Shohei, KANEKO Makoto, AIZAWA Naoko, TANAKA Yuji, KUNIKATA Hiroshi, NAKAZAWA Toru

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2014　(0)　395-396　2014
Publisher: The Japan Society of Mechanical Engineers
極早期緑内障病態研究 2:極早期緑内障患者における視神経乳頭血流の薬剤反応性

相澤奈帆子, 國方彦志, 津田聡, 志賀由己浩, 清田直樹, 面高宗子, 横山悠, 劉孟林, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　25th　86　2014
前眼部偏光光干渉断層計による濾過胞内の線維化組織の観察

國分太貴, 津田聡, 山成正宏, 田中佑治, 志賀由己浩, 横山悠, 国松志保, 高橋秀肇, 丸山和一, 國方彦志, 中澤徹

日本緑内障学会抄録集　25th　90-90　2014
Publisher: 日本緑内障学会
裂孔原性網膜剥離眼の視神経乳頭血流解析からみた視力予後因子

相澤奈帆子, 國方彦志, 新田文彦, 鈴木哲章, 油井理恵子, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　53rd　83　2014
黄斑剥離を伴う裂孔原性網膜剥離における視力予後予測因子

鈴木哲章, 國方彦志, 相澤奈帆子, 阿部俊明, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　53rd　83　2014
レーザースペックルによる網膜静脈分枝閉塞症でのラニビズマブ投与前後の眼血流変化

新田文彦, 國方彦志, 相澤奈帆子, 伊藤梓, 阿部俊明, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　53rd　97　2014
濾過胞の生存に関与する前房水サイトカインの検討

國分太貴, 津田聡, 安田正幸, 清水愛, 横山悠, 渡邊亮, 劉孟林, 国松志保, 丸山和一, 國方彦志, 中澤徹

日本眼科学会雑誌　118　(1)　48-48　2014/01
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障における神経保護治療

NAKAZAWA Toru

Medical Science Digest　40　314-317　2014
トラベクレクトミー後の濾過胞痕化とその評価

NAKAZAWA Toru

眼科手術　27　(4)　491-498　2014
Publisher: (公社)日本眼科手術学会
ISSN： 0914-6806
連載第五回日本人のヒット論文ー本音で語る苦労話－

NAKAZAWA Toru

Retina Medicine　3　(2)　2014
特集図で早わかり実戦!眼科薬理 II.眼科臨床薬理各論 7.緑内障原発開放隅角緑内障の臨床薬理

中澤徹

臨床眼科　67　(11)　275-280　2013/10/30
Publisher: 株式会社医学書院
DOI： 10.11477/mf.1410105012 　

ISSN： 0370-5579

eISSN： 1882-1308
ぶどう膜炎を合併したMPPEから増殖性硝子体網膜症に至った1例

高橋秀肇, 阿部俊明, 國方彦志, 中澤徹

眼科臨床紀要　6　(10)　825-825　2013/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
急性網膜壊死52眼に対する硝子体手術後成績

前川重人, 阿部俊明, 國方彦志, 中澤徹

眼科臨床紀要　6　(10)　841-841　2013/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
トロピカミド・フェニレフリン塩酸塩液点眼による眼底血流への影響

相澤奈帆子, 國方彦志, 新田文彦, 阿部俊明, 中澤徹

眼科臨床紀要　6　(10)　806-806　2013/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
ペガプタニブ硝子体投与の眼循環血流に与える影響

新田文彦, 國方彦志, 阿部俊明, 中澤徹

眼科臨床紀要　6　(10)　834-834　2013/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
原発性アルドステロン症における非侵襲的眼血流測定法・レーザースペックルフローグラフィによる細動脈血管障害の評価

工藤正孝, 新田文彦, 國方彦志, 麦倉俊司, 小野美澄, 岩倉芳倫, 松田謙, 森本玲, 相澤奈帆子, 高橋秀肇, 高橋昭喜, 中澤徹, 伊藤貞嘉, 佐藤文俊

日本高血圧学会総会プログラム・抄録集　36回　286-286　2013/10
Publisher: (NPO)日本高血圧学会
無光覚に陥った加齢黄斑変性の背景に関する検討

萱場寛子, 阿部俊明, 國方彦志, 新田文彦, 中澤徹

眼科臨床紀要　6　(9)　729-733　2013/09/15
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
ステレオ眼底カメラによる緑内障性視神経乳頭障害指標(DDLS)の算出

北岡康史, 谷戸正樹, 新田耕治, 片井麻貴, 横山悠, 面高宗子, 津田聡, 中川俊明, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　60-60　2013/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより計測した視神経乳頭形状パラメーターを用いた乳頭形状新分類

谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 津田聡, 中川俊明, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　60-60　2013/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより計測した視神経乳頭形状パラメーターによる乳頭形状4群分類

新田耕治, 谷戸正樹, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 津田聡, 中川俊明, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　61-61　2013/09
Publisher: 日本緑内障学会
緑内障進行におけるLSFG乳頭波形解析の検討

高橋麻衣, 高橋秀肇, 志賀由己浩, 面高宗子, 今野瑛之, 津田聡, 横山悠, 国松志保, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　58-58　2013/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより測定した視神経乳頭傾斜角度と他のパラメーターの相関

横山悠, 谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 面高宗子, 津田聡, 中川俊明, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　61-61　2013/09
Publisher: 日本緑内障学会
SS-OCTによるBMO手動解析スキャンパターン間の差異と再現性の検討

高橋世理, 津田聡, 面高宗子, 鎌田泰彰, 横山悠, 中澤徹

日本緑内障学会抄録集　24回　62-62　2013/09
Publisher: 日本緑内障学会
緑内障患者の乳頭形状分類を用いた乳頭周囲網膜神経線維層厚の障害部位の検討

高田菜生子, 面高宗子, 志賀由己浩, 津田聡, 横山悠, 檜森紀子, 劉孟林, 高橋秀肇, 中澤徹

日本緑内障学会抄録集　24回　65-65　2013/09
Publisher: 日本緑内障学会
緑内障半視野進行症例におけるMDスロープ、半視野TDスロープ、OCTベース視野セクターTDスロープの比較

今野瑛之, 国松志保, 横山悠, 面高宗子, 津田聡, 高橋秀肇, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　111-111　2013/09
Publisher: 日本緑内障学会
極早期緑内障患者のプロスタグランジン関連薬による乳頭循環反応性に関与する因子

清田直樹, 志賀由己浩, 津田聡, 相澤奈帆子, 横山悠, 面高宗子, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　24回　114-114　2013/09
Publisher: 日本緑内障学会
極早期緑内障患者における視神経乳頭血流波形に関する検討

志賀由己浩, 面高宗子, 清田直樹, 津田聡, 相澤奈帆子, 横山悠, 安井朝輝, 加藤圭一, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　114-114　2013/09
Publisher: 日本緑内障学会
緑内障進行における血流関与についての検討

高橋秀肇, 高橋麻衣, 今野瑛之, 志賀由己浩, 面高宗子, 津田聡, 横山悠, 国松志保, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　114-114　2013/09
Publisher: 日本緑内障学会
東北大学病院における毛様体光凝固術の術後成績

多田麻子, 国松志保, 丸山和一, 高橋秀肇, 劉孟林, 渡邉亮, 檜森紀子, 横山悠, 津田聡, 志賀由己浩, 中澤徹

日本緑内障学会抄録集　24回　152-152　2013/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより測定した視神経乳頭リム偏心率と他のパラメーターの相関

片井麻貴, 谷戸正樹, 新田耕治, 北岡康史, 横山悠, 面高宗子, 津田聡, 中川俊明, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　60-60　2013/09
Publisher: 日本緑内障学会
濾過胞の生存に関与する前房水サイトカインの検討

國分太貴, 津田聡, 安田正幸, 清水愛, 横山悠, 渡邉亮, 劉孟林, 国松志保, 丸山和一, 中澤徹

日本緑内障学会抄録集　24回　47-47　2013/09
Publisher: 日本緑内障学会
RNA-Seqによるマウス視神経挫滅後早期における網膜の網羅的遺伝子発現定量解析

田中佑治, 安田正幸, 中澤徹

日本緑内障学会抄録集　24回　51-51　2013/09
Publisher: 日本緑内障学会
緑内障に関連する前房水miRNAマーカーのマイクロアレイ解析

津田聡, 田中佑治, 安田正幸, 佐藤順子, 國分太貴, 中澤徹

日本緑内障学会抄録集　24回　51-51　2013/09
Publisher: 日本緑内障学会
A case of vitreous hemorrhage with blood staining of the cornea treated by 25-gauge vitrectomy with wide-angle viewing system

雪田昌克, 國方彦志, 小林航, 阿部俊明, 小林直樹, 中澤徹

臨床眼科　67　(8)　1331-1336　2013/08/15
Publisher: 医学書院
DOI： 10.11477/mf.1410104864 　

ISSN： 0370-5579

eISSN： 1882-1308
A case of acute retinal necrosis in the fellow eye sixteen years after the first eye

浅野俊一郎, 阿部俊明, 國方彦志, 今留尚人, 高橋麻衣, 中澤徹

臨床眼科　67　(5)　663-667　2013/05/15
Publisher: 医学書院
DOI： 10.11477/mf.1410104710 　

ISSN： 0370-5579

eISSN： 1882-1308
ラボのマネージメントの実際を語る魅力的なラボづくりに向けて

石田晋, 小沢洋子, 近藤峰生, 中澤徹, 安川力, 山城健児

Retina Medicine　2　(1)　1-7　2013/04
Publisher: (株)先端医学社
ISSN： 2187-2384
上方視神経低形成の視神経乳頭血流

相澤奈帆子, 國方彦志, 面高宗子, 檜森紀子, 中澤徹

日本眼科学会雑誌　117　(臨増)　270-270　2013/03/04
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
求心性視野狭窄が自動車運転に与える影響についての検討

宇田川さち子, 大久保真司, 国松志保, 青木由紀, 岩瀬愛子, 福地健郎, 小野浩, 中澤徹, 杉山和久, 新家眞

日本眼科学会雑誌　117　(臨増)　271-271　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
自動車事故回避に必要な視野範囲の検討

国松志保, 中澤徹, 青木由紀, 宇田川さち子, 大久保真司, 杉山和久, 岩瀬愛子, 福地健郎, 小野浩, 新家眞

日本眼科学会雑誌　117　(臨増)　271-271　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者における病期別、年齢別の機能と構造の相関

萱場寛子, 横山悠, 多田麻子, 津田聡, 面高宗子, 國松志保, 丸山和一, 中澤徹

日本眼科学会雑誌　117　(臨増)　334-334　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
前眼部3次元OCTを用いた線維柱帯切除術後の濾過胞の評価

國分太貴, 津田聡, 浅野俊文, 横山悠, 面高宗子, 多田麻子, 渡邉亮, 劉孟林, 國松志保, 高橋秀肇, 丸山和一, 中澤徹

日本眼科学会雑誌　117　(臨増)　338-338　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
線維柱帯切除後の濾過胞における経時的結膜血管面積の定量化

浅野俊文, 津田聡, 國分太貴, 横山悠, 面高宗子, 渡邉亮, 劉孟林, 国松志保, 高橋秀肇, 丸山和一, 中澤徹

日本眼科学会雑誌　117　(臨増)　340-340　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
低酸素応答生理活性蛍光プローブを用いた網膜低酸素領域のin vivoイメージング

津田聡, 田中佑治, 朴文, 國方彦志, 横山悠, 安田正幸, 花岡健二郎, 長野哲雄, 中澤徹

日本眼科学会雑誌　117　(臨増)　280-280　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
エリスロポエチンノックアウトマウスを用いた網膜・視神経の組織学的検討

安田正幸, 劉孟林, 田中佑治, 檜森紀子, 面高宗子, 横山悠, 雪田昌克, 津田聡, 丸山和一, 山本雅之, 中澤徹

日本眼科学会雑誌　117　(臨増)　311-311　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
酸化ストレスによる網膜神経節細胞死におけるカルパインの働き

横山悠, 劉孟林, 山本耕太郎, 安田正幸, 田中佑治, 丸山和一, 中澤徹

日本眼科学会雑誌　117　(臨増)　332-332　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
近視、血流、緑内障の3者関係を考える。

中澤徹

メディカルビューポイント　2013/02
次世代シークエンサーを用いた新規発達緑内障遺伝子の探索

清水愛, 新堀哲也, 青木洋子, 松原洋一, 舟山亮, 長嶋剛史, 中山啓子, 渡邉亮, 長崎正朗, 布施昇男, 中澤徹

日本眼科学会雑誌　117　2013

ISSN： 0029-0203
角膜上皮創傷治癒におけるNrf2の役割

林竜平, 檜森紀子, 田口恵子, 石川幸, 上杉晃司, 伊藤美由紀, DUNCAN Thomas, 中澤徹, 山本雅之, 西田幸二

日本眼科学会雑誌　117　2013

ISSN： 0029-0203
視神経挫滅モデルにおけるROCK阻害薬K-115の神経保護効果

山本耕太郎, 丸山和一, 檜森紀子, 中澤徹

日本緑内障学会抄録集　24th　2013
ミニ知識コーナー知っておくと得をするRetina百科(第2回)OCTの緑内障評価に役立つ知識

面高宗子, 中澤徹

Retina medicine : journal of retina medeicine : 網膜・硝子体領域を中心とした医学情報誌　2　(1)　114-116　2013
Publisher: 先端医学社
ISSN： 2187-2384
ドライビングシミュレータでの対向車の右折時衝突事故と後期緑内障の視野因子の関連

国松志保, 中澤徹, 青木由紀, 宇田川さち子, 大久保真司, 杉山和久, 岩瀬愛子, 福地健郎, 小野浩, 新家眞

日本眼科学会雑誌　117　(1)　51-52　2013/01
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ウノプロストン徐放デバイスの作製と網膜保護効果

永井展裕, 梶弘和, 大浪英之, 山田琢也, 勝倉由樹, 小柳恵理, 西澤松彦, 眞島行彦, 中澤徹, 阿部俊明

日本眼科学会雑誌　117　2013

ISSN： 0029-0203
Mechanical Characteristic Index Expressing Internal Properties of Eyeball

木村洋介, 金子真, 相澤奈帆子, 田中佑治, 國方彦志, 中澤徹

日本機械学会論文集 C編(Web)　79　(799)　450-458 (WEB ONLY)-458　2013
Publisher: 一般社団法人日本機械学会
DOI： 10.1299/kikaic.79.450 　

ISSN： 1884-8354

More details Close

There is a big need for estimating internal properties of eyeball, since they shoud be closely related to eye diseases, such as detached retina. Based on this background, this paper discusses a new bio-marker expressing the mechanical characteristics of internal eyeball. For this purpose, we focus on subjects having vitreum surgery in which vitreum of subject is replaced with succedaneum. With the assistance of high speed camera, the eye deformations before and after operation are captured during air-puff impartment. Through the analysis, we found the difference between the behaviors before and after operation, especially the shape of eye ball immediately after the tip of cornea recovers. We discuss why such different behaviors happen and how we can explain the physics.
極早期緑内障患者における視神経乳頭血流の薬剤反応性

相澤奈帆子, 國方彦志, 津田聡, 志賀由己浩, 面高宗子, 横山悠, 劉孟林, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　24th　115　2013
ウィルス性ぶどう膜炎における硝子体細胞解析について

丸山和一, 稲葉亨, 國方彦志, 望月學, 木下茂, 中澤徹

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集　50th-47th-56th-2nd　84　2013
眼循環と網膜関連疾患の関与を探る

相澤奈帆子, 中澤徹

Retina Medicine　2　(2)　187-190,130-131　2013
Publisher: 先端医学社
ISSN： 2187-2384
眼科疾患における酸化ストレス

檜森紀子, 中澤徹

医学のあゆみ　247　(9)　2013

ISSN： 0039-2359
緑内障に対する神経保護薬の研究開発

田中佑治, 中澤徹

眼科　155　(5)　601-607　2013
Publisher: 金原出版
ISSN： 0016-4488
施設めぐり【外来施設編】東北大学病院眼科

渡邉亮, 横倉俊二, 中澤徹

Retina Medicine　12　(2)　94-95　2013
緑内障における神経保護治療

津田聡, 中澤徹

Medical Science Digest　40　(3)　14-17　2013
OCT 緑内障診療におけるOCTの活用

横山悠, 面高宗子, 中澤徹

Monthly Book Oculista　2　69-77　2013/01
若年者外傷性黄斑円孔に対する硝子体手術後の長期予後

雪田昌克, 國方彦志, 阿部俊明, 新田文彦, 中澤徹

眼科手術　26　133　2012/12/26

ISSN： 0914-6806
眼内レンズ縫着術後の高次収差解析

相澤奈帆子, 國方彦志, 前田直之, 西田幸二, 中澤徹

眼科手術　26　180　2012/12/26

ISSN： 0914-6806
黄斑円孔網膜剥離手術でのゲージ別手術成績比較と小切開硝子体手術(MIVS)の有用性

小林航, 國方彦志, 阿部俊明, 中澤徹

眼科手術　26　116　2012/12/26

ISSN： 0914-6806
Ophthalmological care in Miyagi

66　(12)　1592-1598　2012/11
Publisher: 医学書院
ISSN： 0370-5579
Allergic conjunctivitis

66　(10)　1462-1464　2012/10
Publisher: 医学書院
ISSN： 0370-5579
【生活習慣(病)と網膜関連疾患の関与を探る】緑内障

津田聡, 中澤徹

Retina Medicine　1　(1)　47-52　2012/10
Publisher: (株)先端医学社
ISSN： 2187-2384
巨大裂孔網膜剥離に対するMIVSと20G硝子体手術の比較

國方彦志, 阿部俊明, 新田文彦, 安田正幸, 玉井洋, 相澤奈帆子, 中澤徹

眼科臨床紀要　5　(10)　960-960　2012/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
加齢黄斑変性症におけるラニビズマブ硝子体内投与前後の眼循環血流変化

新田文彦, 國方彦志, 安田正幸, 玉井洋, 阿部俊明, 中澤徹

眼科臨床紀要　5　(10)　976-977　2012/10
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
ドライビングシミュレータでの対向車の右折時衝突事故と後期緑内障の視野因子の関連

国松志保, 中澤徹, 青木由紀, 宇田川さち子, 大久保真司, 杉山和久, 岩瀬愛子, 福地健郎, 小野浩, 新家眞

日本緑内障学会抄録集　23回　67-67　2012/09
Publisher: 日本緑内障学会
ドライビングシミュレーターでの信号・標識見落としと後期緑内障の視野因子の関連

福地健郎, 国松志保, 中澤徹, 青木由紀, 宇田川さち子, 大久保真司, 杉山和久, 岩瀬愛子, 小野浩, 新家真

日本緑内障学会抄録集　23回　96-96　2012/09
Publisher: 日本緑内障学会
ステレオ眼底カメラによる視神経乳頭形状解析に関する多施設共同研究(GSAS)の研究デザイン

谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 中川俊明, 中澤徹

日本緑内障学会抄録集　23回　110-110　2012/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより計測した視神経乳頭形状パラメーターの乳頭形状4分類間比較

新田耕治, 谷戸正樹, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 津田聡, 中川俊明, 中澤徹

日本緑内障学会抄録集　23回　110-110　2012/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより計測した視神経乳頭形状パラメーターと眼圧レベルの比較

片井麻貴, 谷戸正樹, 新田耕治, 北岡康史, 横山悠, 中川俊明, 中澤徹

日本緑内障学会抄録集　23回　111-111　2012/09
Publisher: 日本緑内障学会
ステレオ眼底カメラにより計測した視神経乳頭形状パラメーターと視野進行速度の比較

北岡康史, 谷戸正樹, 新田耕治, 片井麻貴, 横山悠, 中川俊明, 中澤徹

日本緑内障学会抄録集　23回　111-111　2012/09
Publisher: 日本緑内障学会
レーザースペックルフローグラフィを用いた乳頭内血管面積の緑内障診断における有用性

前川重人, 志賀由己浩, 面高宗子, 津田聡, 横山悠, 渡邊亮, 劉孟林, 国松志保, 高橋秀肇, 中澤徹

日本緑内障学会抄録集　23回　98-98　2012/09
Publisher: 日本緑内障学会
緑内障評価におけるLSFG-NAVIの新しい波形解析パラメータFlow Acceleration Indexの有用性

今野瑛之, 横山悠, 志賀由己浩, 面高宗子, 津田聡, 渡邊亮, 劉孟林, 国松志保, 高橋秀肇, 中澤徹

日本緑内障学会抄録集　23回　98-98　2012/09
Publisher: 日本緑内障学会
ステレオ眼底カメラによる視神経乳頭形状解析に関する多施設共同研究(GSAS)の乳頭形状パラメーター

横山悠, 谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 面高宗子, 津田聡, 中川俊明, 中澤徹

日本緑内障学会抄録集　23回　110-110　2012/09
Publisher: 日本緑内障学会
切迫早産に対するリトドイン塩酸塩静脈注射後に急性緑内障発作をきたしたプラトー虹彩緑内障の一例

橋本清香, 国松志保, 小林航, 新田文彦, 目黒泰彦, 中澤徹

日本緑内障学会抄録集　23回　142-142　2012/09
Publisher: 日本緑内障学会
局所虚血型緑内障における乳頭周囲網膜神経線維層厚菲薄化の血流閾値

津田聡, 横山悠, 國分太貴, 面高宗子, 劉孟林, 国松志保, 高橋秀肇, 中澤徹

日本緑内障学会抄録集　23回　154-154　2012/09
Publisher: 日本緑内障学会
緑内障眼における視神経乳頭循環と脈絡膜循環の血流波形の差異

國分太貴, 津田聡, 志賀由己浩, 横山悠, 面高宗子, 前川重人, 渡邊亮, 劉孟林, 国松志保, 高橋秀肇, 中澤徹

日本緑内障学会抄録集　23回　159-159　2012/09
Publisher: 日本緑内障学会
黄斑円孔術後に発症した脈絡膜新生血管の一例

伊藤梓, 國方彦志, 阿部俊明, 安田正幸, 中澤徹

眼科臨床紀要　5　(9)　855-859　2012/09
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
正常眼圧緑内障における視神経乳頭血流と皮膚AGEとの相関

高橋秀肇, 金澤紘子, 劉孟林, 安田正幸, 宮田敏男, 中澤徹

日本緑内障学会抄録集　23回　99-99　2012/09
Publisher: 日本緑内障学会
軸索流障害による網膜神経節細胞死のcalpain pathwayの関与

劉孟林, 横山悠, 安田正幸, アハメッド・シャナブ, 檜森紀子, 面高宗子, 渡辺亮, 高野二郎, 西道隆臣, 中澤徹

日本緑内障学会抄録集　23回　102-102　2012/09
Publisher: 日本緑内障学会
正常眼圧緑内障における進行予測因子としての皮膚AGEの有用性

金澤紘子, 劉孟林, 安田正幸, 面高宗子, 橋本清香, 國分太貴, 今野瑛之, 宮田敏男, 佐藤肇, 中澤徹

日本緑内障学会抄録集　23回　112-112　2012/09
Publisher: 日本緑内障学会
アポリポ蛋白質E欠損マウスにおけるカイニン酸障害および軸索障害に対する網膜神経節細胞の保護効果

田中佑治, Ahmed Shanab, 安田正幸, 面高宗子, 横山悠, 劉孟林, 中澤徹

日本緑内障学会抄録集　23回　152-152　2012/09
Publisher: 日本緑内障学会
DNAマイクロアレイによるラタノプロストの神経保護作用の解析

山本耕太郎, 劉孟林, 面高宗子, 安田正幸, 中澤徹

日本緑内障学会抄録集　23回　153-153　2012/09
Publisher: 日本緑内障学会
緑内障患者のMRIにおける視神経評価の有用性

高橋麻衣, 面高宗子, 土井洋, 村田隆紀, 佐藤志保, 舘脇康子, 劉孟林, 国松志保, 高橋昭喜, 中澤徹

日本緑内障学会抄録集　23回　126-126　2012/09
Publisher: 日本緑内障学会
緑内障眼における黄斑部網膜神経節細胞複合体とHumphrey視野検査30-2中心8点との相関

臨床眼科　66　(9)　1319-1323　2012/09
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
神経保護治療の可能性眼科2012年9月臨時増刊号 Vol54 No10 1338-1339

NAKAZAWA Toru

眼科 2012年9月臨時増刊号眼科薬物療法　54　(10)　2012/09
緑内障とドライアイに対する抗酸化物質の可能性

中澤徹

Japan Medicine Monthly 特別編集版　2012/08/30
25G硝子体手術中の脈絡膜剥離

相澤奈帆子, 國方彦志, 岡村知世子, 阿部俊明, 中澤徹

眼科臨床紀要　5　(8)　792-796　2012/08/15

ISSN： 1882-5176
Looking back ophthalmological care for stricken areas

66　(5)　581-586　2012/05/15
Publisher: 株式会社医学書院
DOI： 10.11477/mf.1410104183 　

ISSN： 0370-5579

eISSN： 1882-1308
Postoperative Results of Deep Anterior Lamellar Keratoplasty (DALK) at Tohoku University Hospital

HARIYA Takehiro, YOKOKURA Shunji, UEMATSU Megumi, MEGURO Yasuhiko, SATO Hajime, NISHIDA Kohji, NAKAZAWA Toru

29　(4)　545-548　2012/04/30
Publisher: メディカル葵出版
ISSN： 0910-1810
Authors' reply

Hiroshi Kunikata, Toshiaki Abe, Nobuo Fuse, Toru Nakazawa

Ophthalmic Surgery Lasers and Imaging　43　(2)　175　2012/03

DOI： 10.3928/15428877-20120206-01 　

ISSN： 1542-8877
The Management of Dislocated Intraocular Lenses Reply

Hiroshi Kunikata, Toshiaki Abe, Nobuo Fuse, Toru Nakazawa

OPHTHALMIC SURGERY LASERS & IMAGING　43　(2)　175-175　2012/03

ISSN： 1542-8877
糖尿病黄斑浮腫に対するベバシズマブ・トリアムシノロン併用療法

志村雅彦, 安田佳奈子, 安田尚子, 安田正幸, 中澤徹

日本眼科学会雑誌　116　(臨増)　264-264　2012/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
酸化ストレス研究における網膜神経節細胞純化回収法の確立

檜森紀子, 田口恵子, 劉孟林, 安田正幸, 横山悠, 相澤奈帆子, 面高宗子, 山本雅之, 中澤徹

日本眼科学会雑誌　116　(臨増)　303-303　2012/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
レーザースペックルフローグラフィーLSFG-NAVI(non-mydriaticタイプ)の再現性

相澤奈帆子, 國方彦志, 新田文彦, 志賀由己浩, 永富良一, 牛凱群, 中澤徹

日本眼科学会雑誌　116　(臨増)　304-304　2012/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
健常人でのレーザースペックル(無散瞳タイプ)による眼循環血流の波形解析と年齢の検討

新田文彦, 國方彦志, 永富良一, 牛凱軍, 玉井洋, 阿部俊明, 中澤徹

日本眼科学会雑誌　116　(臨増)　343-343　2012/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者の視放線のMRIパラメータと両眼視野との相関

面高宗子, 土井洋, 大友孝昭, 村田隆紀, 佐藤志保, 舘脇康子, 永坂竜男, 国松志保, 高橋昭喜, 中澤徹

日本眼科学会雑誌　116　(臨増)　352-352　2012/03/01
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
眼球鉄錆症による続発緑内障の1例

野口三太朗, 渡邉亮, 布施昇男, 馬場耕一, 阿部圭子, 山田孝彦, 高橋秀肇, 中澤徹

あたらしい眼科　29　(3)　419-423　2012/03
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
災害現場への初期対応と医療支援体制

NAKAZAWA Toru

メディカル・ビューポイント（MVP）　33　(2)　2012/02
第22回日本緑内障学会モーニングセミナーがん血流をどうみて、これから患者にどう活用すべきか

NAKAZAWA Toru

メディカルビューポイント（MVP）　33　2012/02
マウス網膜神経節細胞障害時におけるHO-1

檜森紀子, 檜森紀子, 田口恵子, 山本雅之, 中澤徹

日本緑内障学会抄録集　23rd　2012
マウス網膜神経節細胞障害における網膜神経節細胞純化回収法の確立

檜森紀子, 田口恵子, 山本雅之, 中澤徹

日本抗加齢医学会総会プログラム・抄録集　12th　2012
創刊号座談会 Retina Medicine誌創刊意義と最新のトピックスを語る

石田晋, 近藤峰生, 中澤徹

Retina medicine : journal of retina medeicine : 網膜・硝子体領域を中心とした医学情報誌　1　(1)　3-9　2012
Publisher: 先端医学社
ISSN： 2187-2384
Central retinal vein occlusion

66　(1)　22-24　2012/01
Publisher: 医学書院
ISSN： 0370-5579
網膜光障害モデルに対する経強膜ドラッグデリバリーデバイスの網膜保護効果

永井展裕, 大浪英之, 梶弘和, 山田琢也, 勝倉由樹, 佐藤真智子, 中澤徹, 西澤松彦, 阿部俊明

日本眼科学会雑誌　116　2012

ISSN： 0029-0203
プロテインドラッグ眼内徐放デバイスによる加齢黄斑変性治療の試み

大浪英之, 永井展裕, 梶弘和, 梶弘和, 山田琢也, 勝倉由樹, 西澤松彦, 西澤松彦, 中澤徹, 阿部俊明

日本DDS学会学術集会プログラム予稿集　28th　2012
経強膜vasohibin徐放デバイスによるラット脈絡膜新生血管抑制

大浪英之, 永井展裕, 梶弘和, 西澤松彦, 涌澤亮介, 佐藤靖史, 中澤徹, 阿部俊明

日本眼科学会雑誌　116　2012

ISSN： 0029-0203
ぶどう膜炎を合併したMPPEから増殖性硝子体網膜症に至った1例

高橋秀肇, 阿部俊明, 國方彦志, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　51st　72　2012
ペガプタニブ硝子体投与の眼循環血流に与える影響

新田文彦, 國方彦志, 阿部俊明, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　51st　83　2012
レーザードップラー流速血流計とレーザースペックルフローグラフィーの相関

浅野俊文, 新田文彦, 國方彦志, 新家眞, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　51st　48　2012
トロピカミド・フェニレフリン塩酸塩液点眼による眼底血流への影響

相澤奈帆子, 國方彦志, 新田文彦, 阿部俊明, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　51st　48　2012
急性網膜壊死52眼に対する硝子体手術後成績

前川重人, 阿部俊明, 國方彦志, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　51st　90　2012
無光覚に陥った加齢黄斑変性の背景に関する検討

萱場寛子, 阿部俊明, 國方彦志, 新田文彦, 中澤徹

日本網膜硝子体学会総会プログラム・講演抄録集　51st　87　2012
交感神経β遮断薬/副作用とその対処

NAKAZAWA Toru

専門医のための眼科診療クオリファイ11緑内障薬物治療ガイド　2012/01
特発性黄斑円孔に対する硝子体手術成績とトリアムシノロンアセトニドの効果

NAKAZAWA Toru

臨床眼科　66　(8)　1219-1224　2012
東日本大震災での石巻における眼科医療

NAKAZAWA Toru

日コレ誌　54　(54)　183-188　2012
Publisher: 日本コンタクトレンズ学会誌編集部
ISSN： 0374-9851
25G硝子体手術中に発見された硝子体腔中の遊離浮遊嚢腫

志賀由己浩, 國方彦志, 渡辺みか, 津田聡, 中澤徹

眼科手術　25　72　2011/12/28

ISSN： 0914-6806
大きな硝子体内異物に対する25G手術による無縫合異物摘出術

國方彦志, 植松恵, 布施昇男, 中澤徹

眼科手術　25　42　2011/12/28

ISSN： 0914-6806
水晶体後嚢切開併施25G硝子体手術後の後発白内障

相澤奈帆子, 國方彦志, 中澤徹

眼科手術　25　68　2011/12/28

ISSN： 0914-6806
PASCALを用いた網膜光凝固後の重篤な漿液性網膜剥離

岡村知世子, 國方彦志, 阿部俊明, 針谷威寛, 中澤徹

眼科手術　25　80　2011/12/28

ISSN： 0914-6806
Diabetic retinopathy

65　(13)　1884-1888　2011/12
Publisher: 医学書院
ISSN： 0370-5579
脳・神経系(感覚器)視覚(緑内障)

NAKAZAWA Toru

論文ができてしまう！疾患モデルマウス表現型解析指南　2011/12
Age-related macular degeneration

65　(12)　1800-1802　2011/11
Publisher: 医学書院
ISSN： 0370-5579
医療の原点を肌で感じた被災地の診療

中澤徹

Santen Issue 46　2011/11
Miami to Japan Eye-Care Rescue Mission: Vision Van Helps with Relief Efforts

Kazuo Tsubota, Tsunehiko Yoshida, Daijiro Kurosaka, Richard K. Lee, Eduardo C. Alfonso, Toru Nakazawa

AMERICAN JOURNAL OF OPHTHALMOLOGY　152　(5)　886-887　2011/11

ISSN： 0002-9394
全身虚血性疾患合併の緑内障における皮膚AGE測定の有用性

金澤紘子, 安田正幸, 志村雅彦, 布施昇男, 宮田敏男, 中澤徹

日本緑内障学会抄録集　22回　101-101　2011/09
Publisher: 日本緑内障学会
新しい眼血流評価とその意識

中澤徹

Medical View Point　2011/09
総合的緑内障研究の必要性

中澤徹

日本の眼科　82　(3)　2011/09
NTGにおける神経保護治療戦略-神経保護には軸索保護・血管保護・グリア保護の３つの視点が重要

中澤徹

World Glaucoma Congress　2011/08
神経保護治療の可能性

中澤徹

Ophthalmic Foresight　2011/08/01
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Interferon

65　(6)　790-792　2011/06
Publisher: 医学書院
ISSN： 0370-5579
Changes in axial length in children measured by noncontact laser interference biometry

65　(6)　817-820　2011/06
Publisher: 医学書院
ISSN： 0370-5579
レーザースペックルフローグラフィを用いた光線力学療法後の血流解析

新田文彦, 國方彦志, 中澤徹, 鬼怒川次郎, 安田正幸, 阿部俊明

臨床眼科　65　(6)　863-868　2011/06
Publisher: (株)医学書院
DOI： 10.11477/mf.1410103693 　

ISSN： 0370-5579
糖尿病黄斑浮腫眼における前房水サイトカインケモカインの解析

國方彦志, 志村雅彦, 中澤徹, 園田康平, 吉村武, 石橋達郎, 西田幸二, 布施昇男

日本眼科学会雑誌　115　(臨増)　232-232　2011/04/15
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
レーザースペックルフローグラフィを用いた体位変換時の眼底血流評価

志賀由己浩, 中澤徹, 横山悠, 相澤菜帆子, 千葉真生, 津田聡

日本眼科学会雑誌　115　(臨増)　200-200　2011/04
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
マウス網膜神経節細胞障害におけるNrf2の役割

檜森紀子, 中澤徹, 田口恵子, 劉孟林, 安田正幸, 面高宗子, シャナブ・アフメド, 山本雅之

日本眼科学会雑誌　115　(臨増)　252-252　2011/04
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
軸索流障害による正常眼圧緑内障モデルにおけるカルパイン阻害剤の神経保護効果

安田正幸, 劉孟林, 檜森紀子, 面高宗子, シャナブ・アフメド, 高野二郎, 西道隆臣, 中澤徹

日本眼科学会雑誌　115　(臨増)　253-253　2011/04
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Pigment epithelium-derived factor

65　(2)　194-196　2011/02
Publisher: 医学書院
ISSN： 0370-5579
眼科医にもわかる生理活性物質と眼疾患の基本 21 臨床編:各種眼疾患と生理活性物質とのかかわり網膜色素変性

中澤満, 中澤徹

臨床眼科　65　(9)　2011

ISSN： 0370-5579
網膜剥離によるミューラー細胞の瘢痕化に対するHSP70の役割

嘉山真紀, 嘉山真紀, 中澤徹, 上野聰樹, MILLER Joan

日本眼科学会雑誌　115　2011

ISSN： 0029-0203
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Hepatocyte growth factor

65　(1)　22-26　2011/01
Publisher: 医学書院
ISSN： 0370-5579
分子徐放デバイスと神経保護

大浪英之, 永井展裕, 梶弘和, 西澤松彦, 佐藤靖史, 中澤徹, 阿部俊明

Proceedings of Clinical Electron Microscopy　31　2011
網膜光障害モデルに対する経強膜DDSの網膜保護効果

永井展裕, 大浪英之, 梶弘和, 梶弘和, 山田琢也, 佐藤真智子, 中澤徹, 西澤松彦, 西澤松彦, 阿部俊明

日本バイオマテリアル学会大会予稿集　33rd　2011
自律神経指標と末梢循環の計測による統合医療の科学的評価方法の確立に関する研究開放隅角緑内障患者の標準化された鍼治療による効果の球後動脈循環動態による検討

仁田新一, 高山真, 中澤徹, 渡部正司, 松田綾音, 神谷哲治, 平野篤, 金子聡一郎, 山本芳子

自律神経指標と末梢循環の計測による統合医療の科学的評価方法の確立に関する研究平成22年度総括・分担研究報告書　2011
加齢黄斑変性症におけるラニビズマブ硝子体内投与前後の眼循環血流変化

新田文彦, 國方彦志, 安田正幸, 玉井洋, 阿部俊明, 中澤徹

日本糖尿病眼学会総会講演抄録集　17th　121　2011
巨大裂孔網膜剥離に対するMIVSと20G硝子体手術の比較

國方彦志, 阿部俊明, 新田文彦, 安田正幸, 玉井洋, 相澤奈帆子, 中澤徹

日本糖尿病眼学会総会講演抄録集　17th　99　2011
25G硝子体手術中の脈絡膜出血

相澤奈帆子, 國方彦志, 岡村知世子, 阿部俊明, 中澤徹

日本糖尿病眼学会総会講演抄録集　17th　108　2011
強度近視黄斑円孔に対する硝子体手術後の脈絡膜新生血管

伊藤梓, 國方彦志, 安田正幸, 新田文彦, 阿部俊明, 中澤徹

日本糖尿病眼学会総会講演抄録集　17th　114　2011
Neuroprotective treatment for glaucoma

64　(13)　1974-1984　2010/12
Publisher: 医学書院
DOI： 10.11477/mf.1410103482 　

ISSN： 0370-5579

eISSN： 1882-1308
特集基礎研究から難治性眼疾患のブレークスルーをねらえ:緑内障の神経保護治療

NAKAZAWA Toru

臨床眼科　64　(13)　1968-1972　2010/12
Publisher: (株)医学書院
ISSN： 0370-5579

eISSN： 1882-1308
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Interleukin-6

64　(12)　1842-1844　2010/11
Publisher: 医学書院
ISSN： 0370-5579
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Brain-derived neurotrophic factor

64　(10)　1664-1667　2010/10
Publisher: 医学書院
DOI： 10.11477/mf.1410103359 　

ISSN： 0370-5579

eISSN： 1882-1308
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Monocyte chemotactic protein-1

64　(9)　1470-1473　2010/09
Publisher: 医学書院
DOI： 10.11477/mf.1410103324 　

ISSN： 0370-5579

eISSN： 1882-1308
タフルプロスト点眼による視神経乳頭循環への影響

津田聡, 中澤徹, 千葉真生, 相澤奈緒子, 横山悠, 小野省太, 布施昇男

日本緑内障学会抄録集　21回　108-108　2010/09
Publisher: 日本緑内障学会
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Leukemia inhibitory factor

64　(8)　1254-1256　2010/08
Publisher: 医学書院
ISSN： 0370-5579
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: stromal cell-derived factor-1

64　(7)　1070-1073　2010/07
Publisher: 医学書院
ISSN： 0370-5579
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Interleukin-1

64　(6)　848-851　2010/06
Publisher: 医学書院
ISSN： 0370-5579
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Insulin-like growth factor-1

64　(5)　644-646　2010/05
Publisher: 医学書院
ISSN： 0370-5579
原発開放隅角緑内障の治療戦略—特集緑内障治療の現状と課題

中澤徹

医薬ジャーナル = Medicine and drug journal　46　(4)　97-100　2010/04
Publisher: 大阪 : 医薬ジャーナル社
ISSN： 0287-4741
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular disease: Endothelin-1

64　(4)　428-430　2010/04
Publisher: 医学書院
ISSN： 0370-5579
Basic principles of cytokines, neurotrophic factors and other bioactive substances in ocular diseases: vascular endothelial growth factor

64　(3)　280-283　2010/03
Publisher: 医学書院
ISSN： 0370-5579
Tumor necrosis factor α

64　(2)　178-180　2010/02
Publisher: 医学書院
DOI： 10.11477/mf.1410103081 　

ISSN： 0370-5579

eISSN： 1882-1308
軸索流低下による新しい正常眼圧緑内障モデル

中澤徹, 劉孟林, アフメドユセフシャナブ, 西田幸二

日本眼科学会雑誌　114　2010

ISSN： 0029-0203
The development of new glaucoma mice model with the obstruction of axonal flow

Toru Nakazawa, Morin Ryu, Shanab Ahmed

NEUROSCIENCE RESEARCH　68　E256-E256　2010

DOI： 10.1016/j.neures.2010.07.1137 　

ISSN： 0168-0102
網膜興奮毒性における白血球眼内遊走を介した間接的網膜神経細胞死とスタチンによる神経保護作用

中澤徹

東北医学雑誌　121　(1)　62-65　2009/06/25

ISSN： 0040-8700
糖尿病眼症における網膜神経節細胞死の機序解明と神経保護治療の開発

中澤徹

上原記念生命科学財団研究報告集(CD-ROM)　23　2009

ISSN： 2433-3441
Critical role of microglia on axonal degeneration in glaucoma

Toru Nakazawa

JOURNAL OF PHARMACOLOGICAL SCIENCES　109　41P-41P　2009

ISSN： 1347-8613
Dexamethasone suppresses retinal detachment-induced photoreceptor loss

Toru Nakazawa, Morin Ryu, Ahmed Sharmb, Kohji Nishida

NEUROSCIENCE RESEARCH　65　S67-S67　2009

DOI： 10.1016/j.neures.2009.09.214 　

ISSN： 0168-0102
Comparative Therapy Evaluation of Intravitreal Bevacizumab and Triamcinolone Acetonide on Persistent Diffuse Diabetic Macular Edema REPLY

Masahiko Shimura, Toru Nakazawa, Kanako Yasuda

AMERICAN JOURNAL OF OPHTHALMOLOGY　146　(6)　974-975　2008/12

ISSN： 0002-9394
Understanding the mechanism of retinal detachment-induced photoreceptor apoptosis : neuroprotective treatments for photoreceptor apoptosis

NAKAZAWA Toru, SHIMURA Masahiko, NISHIDA Kohji

28　(6)　522-528　2008/11/25

ISSN： 1880-9693
正常眼圧緑内障の危険因子

中澤徹

あたらしい眼科 = Journal of the eye　25　(10)　1389-1390　2008/10/30

ISSN： 0910-1810
Clinical Outcome for Primary and Recurrent Pterygium and Risk Factors for Primary Pterygium Recurrence

HIMORI Noriko, NAKAZAWA Toru, RYU Morin, YOKOYAMA Yu, YOKOKURA Shunji, KUBOTA Akira, NISHIDA Kohji

Journal of the eye　25　(10)　1421-1425　2008/10/30
Publisher: メディカル葵出版
ISSN： 0910-1810
緑内障における軸索変性

中澤徹

あたらしい眼科 = Journal of the eye　25　(9)　1253-1254　2008/09/30

ISSN： 0910-1810
緑内障による網膜神経節細胞死における腫瘍壊死因子 (Tumor Necrosis Factor-alpha) の細胞障害的役割

中澤徹

東北医学雑誌　120　(1)　99-102　2008/06/25

ISSN： 0040-8700
眼科疾患に対する神経保護治療

中澤徹

あたらしい眼科 = Journal of the eye　25　(4)　511-513　2008/04/30
Publisher: メディカル葵出版
ISSN： 0910-1810
網膜傷害モデルにおけるミューラー細胞を介した神経保護作用

中澤徹, 志村雅彦, 劉孟林, 遠藤昌吾, 西田幸二

日本眼科学会雑誌　112　210　2008/03/15

ISSN： 0029-0203
深層角膜移植術(DLKP)におけるhooking法の有用性

土山麻貴, 久保田享, 横倉俊二, 中澤徹, 西田幸二

眼科手術　22　2008

ISSN： 0914-6806
糖尿病黄斑浮腫に対する汎網膜光凝固による硝子体中サイトカイン濃度の変化

志村雅彦, 安田佳奈子, 中澤徹, 塩野貴

日本糖尿病眼学会誌　12　2008

ISSN： 1881-753X
A Case of Deep Lamellar Keratoplasty Managed by a Hooking Technique for Cicatricial Corneal Opacity Due to Luetic Interstitial Keratitis

NAKAZAWA Toru, YOKOKURA Shunji, MEGURO Yasuhiko, RYU Morin, KUBOTA Akira, NISHIDA Kohji

58　(6)　379-383　2007/06/28

ISSN： 0015-5667
網膜静脈分枝閉塞及び糖尿病黄斑浮腫における硝子体RANTES及びSDF‐1濃度

志村雅彦, 安田佳奈子, 中澤徹, 松久恵里, 國方彦志, 坂本泰二, 西田幸二

日本眼科学会雑誌　111　(臨増)　229-229　2007/03/15
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜損傷における炎症性サイトカインと神経変性のメカニズム

中澤徹, 西田幸二

日本臨床免疫学会会誌　30　(4)　2007

ISSN： 0911-4300
ラット脈絡膜新生血管モデルを用いた光線力学的治療における細胞死のメカニズム

松原明久, 小椋祐一郎, 中澤徹, 野田航介, Gragoudas Evangelos S, Miller Joan W

日本眼科学会雑誌　110　(臨増)　109-109　2006/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜中心静脈分枝閉塞症に対する硝子体手術予後と硝子体中サイトカイン濃度

志村雅彦, 安田佳奈子, 中澤徹, 國方彦志, 塩野貴

日本眼科学会雑誌　110　(臨増)　129-129　2006/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Characterization of effects of systemic antibiotics in a rat model of retinal detachment

SI Pachydaki, L Sobrin, T Nakazawa, CL Grosskreutz, DN Zacks, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　2005

ISSN： 0146-0404
Blood retina barrier function and angiogenesis in apolipoprotein E deficient mice

D Skondra, HJ Zambarakji, T Nakazawa, E Connolly, K Thomas, AM Lane, ES Gragoudas, JW Miller, A Hafezi-Moghadam

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　2005

ISSN： 0146-0404
Pitavastatin prevents leukocyte recruitment to retinal tissue following N-methyl-D-aspartate injury

H Takahashi, T Nakazawa, H Kudo, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　2005

ISSN： 0146-0404
Dose-dependant effect of pitavastatin on fluorescein angiography leakage and VEGF expression in a mouse model of choroidal neovascularisation

HJ Zambarakji, T Nakazawa, E Connolly, A Lane, S Mallemadugula, N Michaud, A Hafezi-Moghadam, ES Gragoudas, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　2005

ISSN： 0146-0404
Effect of systemic neuroprotective agents on photoreceptor apoptosis in a rat model of retinal detachment

L Sobrin, SI Pachydaki, T Nakazawa, CL Grosskreutz, DN Zacks, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　2005

ISSN： 0146-0404
Pattern Reversal VEP and contrast sensitive accurate test after acupuncture stimulation in glaucoma subjects

Y Sagara, N Fuse, T Nakazawa, K Watanabe, H Akiyama, M Seimiya, S Yokokura, M Kurusu, T Seki, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　46　2005

ISSN： 0146-0404
Application of Acupuncture in Ophthalmology

WATANABE Kei, NAKAZAWA Toru, SAGARA Yoshiko, FUSE Nobuo, TAKAHASHI Kana, AKIYAMA Hiroshi, SEIMIYA Motohiko, NAKAMURA Masahiko, SEKI Takashi, KURUSU Masayuki, SHIMURA Masahiko, TAMAI Makoto

14　(1)　71-74　2004/09/20

ISSN： 0917-4338
Pitavastatin protects against retinal ganglion cell damage injured by intravitreous application of N-methyl-D-aspartate and optic nerve axotomy

H Takahashi, T Nakazawa, M Shimura, K Yasuda, N Fuse, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　45　U358-U358　2004/04

ISSN： 0146-0404
Expression and distribution of the inwardly rectifying K+ channel Kir7.1 in the non-pigmented ciliary epithelium of porcine retina

K Yasuada, M Shimara, T Nakazawa, BA Hughes, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　45　U565-U565　2004/04

ISSN： 0146-0404
Pigment epithelial-derived factor (PEDF) inhibits apoptosis in a rat model of retinal detachment

L Sobrin, TA Young, A Sharma, T Nakazawa, CL Grosskreutz, DN Zacks, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　45　U769-U769　2004/04

ISSN： 0146-0404
P-VEP (pattern reversal visual evoked potentials) to identify the improvements of visual functions by acupuncture stimuli

Y Sagara, K Watanabe, T Nakazawa, N Fuse, K Takahashi, H Akiyama, M Seimiya, T Seki, M Kurusu, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　45　U660-U660　2004/04

ISSN： 0146-0404
Latanoprost prevents retinal ganglion cell death induced by N-methyl-D-aspartate or optic nerve axotomy

H Kudo, T Nakazawa, K Kashiwagi, M Shimura, H Takahashi, N Fuse, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　45　U355-U355　2004/04

ISSN： 0146-0404
Intravitreal administration of N-methyl-D-aspartate (NMDA) induces cell death both in the ganglion and arracrine cells with the suppression ofprotein kinase B (Akt) activity.

T Nakazawa, M Shimura, S Endo, N Fuse, H Takahashi, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　45　U354-U354　2004/04

ISSN： 0146-0404
Evaluation of human deleted in polyposis 1-like 1 as a candidate glaucoma gene

N Fuse, H Sato, M Seimiya, T Nakazawa, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　45　U439-U439　2004/04

ISSN： 0146-0404
Modulation of apoptosis following combination PEDF and photodynamic therapy for choroidal neovascularization in the rat model

TA Young, T Nakazawa, L Sobrin, A Sharma, CL Grosskreutz, ES Gragoudas, JW Miller

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　45　U804-U804　2004/04

ISSN： 0146-0404
Application of Acupuncture in Ophthalmology

WATANABE Kei, NAKAZAWA Toru, SAGARA Yoshiko, FUSE Nobuo, TAKAHASHI Kana, AKIYAMA Hiroshi, SEIMIYA Motohiko, NAKAMURA Masahiko, SEKI Takashi, KURUSU Masayuki, SHIMURA Masahiko, TAMAI Makoto

Journal of the eye　21　(3)　393-396　2004/03/30
Publisher: メディカル葵出版
ISSN： 0910-1810
網膜色素変性の視機能の診断法について教えてください

中澤徹, 玉井信

あたらしい眼科 = Journal of the eye　19　22-24　2002/12/20

ISSN： 0910-1810
Nipradilol inhibits apoptosis in PC12 by preventing the activation of caspase-3

H Tomita, E Sugano, T Nakazawa, T Abe, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　43　U1168-U1168　2002/05

ISSN： 0146-0404
MAP kinase inhibitor, PD98059, inhibits rat RPE cell replication by cell cycle arrest

K Yamaguchi, H Tomita, E Sugano, T Nakazawa, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　43　U1291-U1291　2002/05

ISSN： 0146-0404
Functional properties of inward rectifier potassium channel in porcaine iris pigment epithelium

K Yasuda, M Shimura, H Tomita, E Sugano, T Nakazawa, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　43　U154-U154　2002/05

ISSN： 0146-0404
虹彩色素上皮細胞における内向き整流性カリウムチャネル

安田佳奈子, 志村雅彦, 中沢徹, 富田浩史, 菅野江理子, 玉井信

日本眼科学会雑誌　106　(臨増)　184-184　2002/04/25
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
虹彩色素上皮細胞移植法を応用した網膜遺伝子治療におけるウイルスベクターの全身副作用の検討

吉岡由貴, 山口克宏, 富田浩史, 中沢徹, 山下あさひ, 菅野江里子, 玉井信

日本眼科学会雑誌　106　(臨増)　185-185　2002/04/25
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜の発生再生過程における神経栄養因子シグナル応答. 網膜視神経の発生と再生

中澤徹

39　28-37　2002
軸索切断による網膜神経節細胞死に対するNipradilolの保護作用

中沢徹, 富田浩史, 玉井信

日本眼科学会雑誌　105　(臨増)　223-223　2001/03/15
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
網膜虚血による網膜神経節細胞死におけるPI3Kの役割

富田浩史, 中沢徹, 玉井信

日本眼科学会雑誌　105　(臨増)　225-225　2001/03/15
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Establishment of retinal cell line from temperature sensitive SV40 large T antigen transgenic rat.

H Tomita, Y Nikami, T Abe, T Nakazawa, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　42　(4)　S634-S634　2001/03

ISSN： 0146-0404
Activation of ERK in the ischemia-reperfusion rat retina

H Akiyama, T Nakazawa, H Tomita, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　42　(4)　S196-S196　2001/03

ISSN： 0146-0404
Nipradilol possess a neuroprotective effect in the axotomised rat retinal ganglion cells via nitric oxide-dependent pathway.

T Nakazawa, H Tomita, Y Yoshioka, S Kuwahara, H Akiyama, K Takahashi, Y Sato, M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　42　(4)　S24-S24　2001/03

ISSN： 0146-0404
血清除去により誘発されるPC12細胞のアポトーシスに対するNipradilolの保護作用

富田浩史, 中沢徹, 菅野江里子, 玉井信

日本眼薬理学会プログラム・講演抄録集　21st　129　2001
Involvement of N-Shc/ShcC phosphorylation and activation of MAPK and PI3K during BDNF-induced survival of RGCs.

T Nakazawa, T Furuyama, M Sato, Nakano, I, M Tamai, N Mori

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　41　(4)　S190-S190　2000/03

ISSN： 0146-0404
トラベクレクトミー私のこだわり「眼科グラフィック」Vol.4no.4 325

NAKAZAWA Toru

眼科グラフィック　4　(4)　325
構造と機能からみた緑内障診断P1-8 第69回日本臨床眼科学会ランチョンセミナー記録集

NAKAZAWA Toru

Show all ︎Show first 5

Books and Other Publications 11

標準眼科学

園田, 康平, 中澤, 徹, 辻川, 明孝, 山城, 健児, 雑賀, 司珠也, 中澤, 満, 村上, 晶

医学書院　2024/03

ISBN: 9784260053600
日常人間ドック : 2040年からのヘルスケアメッセージ

東北大学

パレード,星雲社(発売)　2023/06

ISBN: 9784434316371
All About開放隅角緑内障

山本, 哲也, 谷原, 秀信, 吉村, 長久, 後藤, 浩

医学書院　2022/04

ISBN: 9784260049337
眼科スゴ技緑内障の診断・治療・手術 : 診療の基本から最新知識まで緑内障の「今」がわかる!

中澤, 徹

メディカ出版　2020/05

ISBN: 9784840472296
緑内障道場診断・治療の一手ご指南 p157-167 点眼治療を行い眼圧は低いのに視野障害が進行します！

中澤徹

医学書院　2019/04
前視野緑内障に向き合う : PPGを発見した時,どう考え管理するか

中澤, 徹

文光堂　2016/10

ISBN: 9784830655487
眼科診療マイスター

飯田, 知弘, 中沢, 徹, 堀, 裕一

メジカルビュー社
Ocular Blood Flow in Myopic Glaucoma pp.97-133Myopia and Glaucoma 2015 Springer

NAKAZAWA Toru
Calcium and Calpain Activation pp.13-24 Myopia and Glaucoma 2014 Springer

NAKAZAWA Toru
Neuroprotection and Neuroregeneration for Retinal Diseases 2014 Springer

NAKAZAWA Toru
緑内障 p80－109 標準眼科第13版医学書院 2016/03/01

中澤徹

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Presentations 158

東北大COIの進める眼の健康のためのデータ連携

中澤徹大畑純

COI V1 共催シンポジウム~COIの進めるヘルスケアデータ利活用・連携・標準化への挑戦~　2021/09/29
Asia Glaucoma Academy 1st Conference 座長東京

中澤徹

2019/09/28
第8回Sendagi Ophthalmic Seminar 東京

中澤徹

2019/09/25
ビジョンセミナー for コメディカル座長東京

中澤徹

2019/09/23
第１回Translational Research Conference for Neuroprotection 座長東京

中澤徹

2019/09/21
第30回日本緑内障学会熊本

中澤徹

2019/09/06
眼科臨床実践講座2019 東京

中澤徹

2019/08/18
ふくしま緑内障セミナー

中澤徹

2019/08/03
仙台心血管生活習慣病医療連携講演会

中澤徹

2019/07/29
第5回宮城緑内障インストラクションセミナー座長仙台

中澤徹

2019/07/27
石川県眼科病診連携の会

中澤徹

2019/07/11
山形県眼科集団会

中澤徹

2019/06/16
Miyagi Retina Academy 2019 座長

中澤徹

2019/05/16
2019年度福岡県眼科医会総会講演会「緑内障診療の最近の話題」

中澤徹

2019/05/11
第26回茨城EYE FORUM

中澤徹

2019/05/10
第123回日本眼科学会総会東京

中澤徹

2019/04/18
第8回名古屋OCT勉強会名古屋

中澤徹

2019/04/06
目からウロコの眼科の話「冷え症、やせ型、完璧主義…緑内障になりやすいのは？」

中澤徹

第11回元気！健康！フェアinとうほく仙台　2019/04/06
第4回Systemic and Ocular Disease Symposium 仙台

中澤徹

2019/01/26
Ophthalmology Specialist Seminar 2019 仙台

中澤徹

2019/01/12
東北眼疾患病態研究会座長仙台

中澤徹

2018/11/29
眼科レーザースペックル研究会東京

中澤徹

2018/11/24
三重県眼科ジョイントフォーラム2018 三重

中澤徹

2018/11/18
Cataract Update Seminar in Sendai 仙台

中澤徹

2018/11/04
OCT Update Seminar 2018 仙台

中澤徹

2018/11/01
宮城県歯科医師会第19回東北大学病院医学講座仙台

中澤徹

2018/10/28
第6回北日本緑内障講演会札幌

中澤徹

2018/09/29
第29回緑内障学会新潟

中澤徹

2018/09/14
第7回なんかい眼科フォーラム大阪

中澤徹

2018/09/08
Glaucoma Research Society meeting 2018 イタリア

中澤徹

2018/08/29
眼科臨床実践講座２０１８東京

中澤徹

2018/08/25
第15回宮城県セミナー

中澤徹

2018/08/04
第22回沖縄眼疾患フォーラム沖縄

中澤徹

2018/07/14
緑内障診療アップデート第2回Nagasaki Opthalmology Seminar 長崎

中澤徹

2018/06/28
第15回静岡平成30年静岡東部眼科フォーラム

中澤徹

2018/05/31
緑内障Web講演会（仙台）

中澤徹

2018/04/26
iStent 講習会（仙台）

中澤徹

2018/04/08
第4回宮城インストラクションセミナー（仙台）

中澤徹

2018/03/31
第3回Systemic and Ocular Disease Symposium

中澤徹

2018/03/31
多摩地区眼科懇話会学術セミナー（東京）

中澤徹

2018/03/24
第12回東北眼科フォーラム（仙台）

中澤徹

2018/03/17
第22回千葉緑内障研究会（千葉）

中澤徹

2018/03/15
札幌眼科集談会（札幌）

中澤徹

2018/03/10
第376回熊本県眼科医会研修会（熊本）

中澤徹

2018/01/21
第19回Japan Glaucoma Council （東京）

中澤徹

2017/12/16
『緑内障診療の質を向上するために』第103回秋田県眼科集談会（秋田）

中澤徹

2017/12/10
Sendai RVO Expert Meeting 座長（仙台）

中澤徹

2017/11/19
緑内障から自分を守るために知っておくこと；坂総合病院市民公開講座緑内障とアイバンク講演（塩釜）

中澤徹

2017/11/11
第5回北日本緑内障講演会（仙台）

中澤徹

2017/09/24
Cataract Update Seminar in Sendai(仙台)

中澤徹

2017/09/24
第14回宮城県セミナー（仙台）

中澤徹

2017/09/09
「緑内障で失明しないために出来ること」南大阪眼科勉強会（近畿大学）特別講演（大阪）

中澤徹

2017/08/26
症例から学ぶ緑内障鑑別診断眼科臨床実践講座（東京）

中澤徹

2017/08/20
角膜疾患治療アップデート眼科臨床実践講座（東京）

中澤徹

2017/08/20
緑内障診療～OCTによる構造からのアプローチ～第96回丘山地学眼科権誘拐OCT（岡山）

中澤徹

2017/08/19
緑内障のトランスレーショナルリサーチ神戸（理化学研究所多細胞システム形成研究センター（CDB））（神戸）

中澤徹

2017/08/03
緑内障アップデート福島PF講演会（福島）

中澤徹

2017/07/15
第２回AGTSの会（仙台）

中澤徹

2017/07/07
社会に役立ついい眼科医NORSの会（Nara Ophthalmic Resident Studygropup)（大阪市)

中澤徹

2017/06/24
視覚を護る・取り戻す2017（仙台）

中澤徹

2017/05/20
第三回宮城県緑内障インストラクションセミナー2017（仙台）

中澤徹

2017/05/13
眼血流と緑内障リスクファクター第10回緑内障ワークショップ（仙台）

中澤徹

2017/04/08
第10回GSミーティング

NAKAZAWA Toru

2017/04/01
第4回東邦オフサルモロジーサミット研究会（東京）

中澤徹

2017/03/17
東北大学眼科学教室（仙台）

中澤徹

100周年記念式典　2017/03/11
緑内障診療の質を向上するために第４回雪明新潟眼科フォーラム（ゆきあかり）

中澤徹

2017/02/19
知っていると得する緑内障診察のポイント第11回埼玉臨床眼科セミナー（埼玉）

中澤徹

2017/02/10
緑内障診療の質を向上するために弟203回茨城県眼科医会学術講演回（茨城）

中澤徹

2017/01/22
新たな宮城県の緑内障診療体系（仙台）

中澤徹

2017/01/21
緑内障研究の最前線 Cutting-edge in Glaucoma Research神戸大学大学院講義（神戸）

中澤徹

2016/11/11
緑内障進行に役立つ知識大森眼科学術研究会（東京）

中澤徹

2016/08/03
分かりやすい緑内障講座弟8回五橋地域医療連携講座（仙台）

中澤徹

2016/08/01
知っていると得する緑内障診断のポイント第10回鳥取県眼科フォーラム（鳥取）

中澤徹

2016/07/30
PPGとどう向き合うか眼科臨床実践講座2016（東京）

中澤徹

2016/07/18
神経保護研究のアップデート第１回AGTSの会（仙台）

中澤徹

2016/07/09
Effect of a PG on optic nerve head blood flow in ryes with preperimetric glaucoma Asia and EU Joint Peivate Symposium2016 チェコ

NAKAZAWA Toru

2016/06/18
緑内障診断アップデート弟10会四国Eyeランドセミナー（香川）

中澤徹

2016/05/21
緑内障治療に関して弟4回Marunouchi Ophthalmic Seminar(東京)

中澤徹

2016/04/22
緑内障診断に役立つ緑内障の細分化平成28年度仙台市眼科医会総会並びに眼底検査登録研修会（仙台）

中澤徹

2016/04/20
9割の人が気づけない目の病気～緑内障の対策と治療第8回元気！健康！フェアin とうほく（仙台）

中澤徹

2016/04/03
わかりやすい緑内障講座第117回いきいき健康講座（松島）

中澤徹

2016/02/18
緑内障診断アップデート大阪眼科集談会（大阪）

中澤徹

2016/02/05
構造機能からみた緑内障診断第8回高知OPHTHALMICセミナー（高知）

中澤徹

2016/01/23
知っていると得する緑内障診療のポイント

中澤徹

第11回 YOKOHAMA病身連携の会横浜 2016　2016
知っていると得する緑内障診療のポイント（横浜）

中澤徹

弟11回YOKOHAMA病診連携の会　2016
緑内障進行に役立つ知識釧路緑内障懇話会（釧路）

中澤徹

2015/11/28
緑内障進行に役立つ知識瀬戸内眼科コロシアム2015（岡山）

中澤徹

2015/10/18
緑内障創薬の一元化 Bio japan(横浜)

中澤徹

2015/10/14
超高齢化社会における眼科の取り組み坂総合病院講演会（塩竈）

中澤徹

2015/09/24
Update of Glaucoma Therapy Drug Delivery Advisory Panel Meeting（大阪）

中澤徹

2015/08/25
網膜静脈閉塞症は治療できるのか？黄斑疾患セミナー（仙台）

中澤徹

2015/08/08
いわき市眼科フォーラムめひかり会（いわき市）

中澤徹

2015/07/31
メヂカラ intimate眼科サマーキャンプ（木更津）

中澤徹

2015/07/25
今後の病診連携第一回宮城緑内障インストラクションセミナー（仙台）

中澤徹

2015/07/11
緑内障診療の新しい展開第85回九州眼科学会モーニングセミナー（鹿児島）

中澤徹

2015/07/11
緑内障診断の落とし穴（全身疾患含む）眼科臨床実践講座2015（東京）

中澤徹

2015/05/16
わかりやすい緑内障講座宮城県眼科学会主催目の健康講座（仙台）

中澤徹

2015/05/16
見える喜びいつまでも～知っておきたい緑内障の最新情報～第７回元気！健康！フェアin とうほく（仙台）

中澤徹

2015/04/04
Glaucoma and Ocular Blood Flow TAFLOTAN (ソウル)

NAKAZAWA Toru

5th Anniversary Symposium in korea　2015/03/21
Translational research for glaucoma treatment (ロンドン) International-presentation

NAKAZAWA Toru

The UK-Japan Retinal Degeration Symposium　2015/03/12
緑内障：眼圧非依存性因子のアップデート新・眼科診療アップデートセミナー2015in Kyoto(京都)

中澤徹

2015/03/07
緑内障診療の質向上に役立つ検査弟37回京滋緑内障カンファレンス（京都）

中澤徹

2015/02/21
New Era for cataract surgery Cataract Update Seminar in仙台（仙台）

中澤徹

2014/12/14
緑内障診療アップデート大分市第170回大分眼科集団会（大分市）

中澤徹

2014/12/07
「眼血流」第9回６大学眼科Step Upセミナー盛岡（盛岡）

中澤徹

2014/10/26
緑内障診療アップデート第79回横浜市大・神奈川眼科医会研修会（神奈川）

中澤徹

2014/10/09
緑内障診療の質向上に役立つ検査 Tokai Opthalmic アカデミー（名古屋）

中澤徹

2014/10/05
緑内障に学ぶ日常診療グレードアップ（京都）

中澤徹

2014/07/19
緑内障に役立つ検査第6回東邦大学佐倉病院眼科フォーラム（千葉）

中澤徹

2014/07/19
緑内障に学ぶ日常診療グレードアップ第44回京都フォーラム（京都）

中澤徹

2014/07/19
Glaucoma and DDS Drug Delivery Advisory Panel Meeting パリ International-presentation

NAKAZAWA Toru

2014/06/30
緑内障診療の向上のために検査を考える第7回茨城眼科セミナー（茨城）

中澤徹

2014/06/20
近未来の緑内障神経保護治療へのアプローチ沖縄講演会（那覇）

中澤徹

2014/06/01
緑内障診療の質向上に役立つ検査ささなみ眼科研究会（大津）

中澤徹

2014/04/19
「緑内障検査のアップデート」東京都眼科医会学術講演会（東京）

中澤徹

2014/02/15
「緑内障診療の質向上のために検査を考える」第16回長崎視機能フォーラム（長崎）

中澤徹

2014/01/31
緑内障診療アップデート第19回大阪緑内障研究会（大阪）

中澤徹

2014/01/25
緑内障診療アップデート長野県眼科集談会（松本）

中澤徹

2013/12/08
緑内障、神経保護治療からのアプローチ函館眼科医会学術講演会（函館）

中澤徹

2013/10/18
眼科の高い将来性について KORC（東京）

中澤徹

2013/10/04
基礎研究を踏まえた夢のある近未来治療広島大学・山口大学眼科Grand Rounds(山口)

中澤徹

2013/09/14
緑内障診療アップデート北陸眼科学術セミナー（金沢）

中澤徹

2013/09/06
緑内障の新しいアプローチ第５回東北文化学園大学視覚機能学専攻研究会（仙台）

中澤徹

2013/09/01
緑内障診療アップデートファイザーオフサルミックセミナーin Chiba(千葉)

中澤徹

2013/08/30
「世界一受けたい目の講義」わかさ生活チャリティーミュージカル「パパからもらった宝物」（仙台）

中澤徹

2013/08/28
緑内障診療アップデート第72回新潟臨床眼科研究会（新潟）

中澤徹

2013/08/25
緑内障進行判定眼科臨床実践講座2013（東京）

中澤徹

2013/08/04
メヂカラ fundamental 眼科サマーキャンプ（木更津）

中澤徹

2013/07/28
緑内障、神経保護治療からのアプローチ福井県眼科会学術講演会（福井）

中澤徹

2013/06/29
緑内障診療アップデート第13回神奈川眼科セミナー（横浜）

中澤徹

2013/06/22
The neuroprotective treatment for glaucomaに関するセミナー(横浜)

中澤徹

2013/06/21
緑内障診断アップデート第１回お茶の水Ophthalmic Update (東京)

中澤徹

2013/04/13
緑内障、神経保護治療からのアプローチ第94回秋田県眼科集団会（秋田）

中澤徹

2013/04/13
The molecular mechanism of glaucomatous optic neuropathy:learning from a mouse model of axonal damage-induced RGC death Sacred heart Hospital(ソウル韓国)

NAKAZAWA Toru

2012/11/22
Treatment strategy of the recent glaucoam&retina diseaes Glaucoma&Retina Meeting 2012Floridea （U.S.A）

NAKAZAWA Toru

2012/05/06
失明原因第一位の緑内障はどんな病気か石巻医師会講演会（石巻）

中澤徹

2012/03/02
緑内障診療アップデート静岡県眼科集団会（静岡）

中澤徹

2012/02/25
緑内障診療アップデート山形県眼科集談会（山形）

中澤徹

2012/02/19
緑内障神経保護治療 169回九州大学眼科研究会（福岡）

中澤徹

2012/02/11
緑内障診療アップデート福島眼科集団会（福島）

中澤徹

2012/01/22
緑内障の病態ー細胞レベルでの考察宮城眼科集団（仙台）

中澤徹

2012/01/21
緑内障における役者たち、細胞レベルの考察群馬県眼科医会学術講演会前橋

中澤徹

2012/01/20
緑内障における役者たち、細胞レベルの考察三重県学術講演会津

中澤徹

2011/11/26
重症緑内障の見分け方大阪眼科医療勉強会（大阪）

中澤徹

2011/11/26
重症緑内障の見分け方緑内障勉強会（札幌）

中澤徹

緑内障勉強会札幌　2011/11/19
緑内障における役者たち細胞レベルの考察室蘭眼科医会学術講演室蘭

中澤徹

2011/10/28
緑内障診療アップデート秋のみやぎ眼科臨床座談会（仙台）

中澤徹

2011/10/20
緑内障における役者たち第２回湘西眼科アカデミー（相模大野）

中澤徹

2011/10/05
緑内障にかかわる最新のトピックス

中澤徹

第3回山梨県学術講演会山梨　2011/08/27
緑内障にかかわる最新のトピックス第三回山梨県学術講演会（山梨）

中澤徹

2011/08/27
近視眼における緑内障と眼循環の関係緑内障座談会（京都）

中澤徹

2011/08/27
緑内障にかかわる最新のトピックス

中澤徹

第3回山梨県学術講演会岡山　2011/07/29
緑内障における役者たちー細胞レベルの考察第83回岡山大学眼科研究会（岡山）

中澤徹

2011/07/29
近視眼における緑内障と眼循環の関係

中澤徹

緑内障座談会京都　2011/05/22
網膜神経保護治療と参加ストレスの接点

中澤徹

第142回宮崎県眼科医会　2011/04/16
網膜神経保護治療と酸化ストレスとの接点第142回宮崎県眼科医会（宮崎）

中澤徹

2011/04/16
beyond IOP in Glaucoma Allergan Glaucoma Lunch Symposium APAO

NAKAZAWA Toru
緑内障診療～機能と構造からのアプローチ～（札幌）

中澤徹

弟7回北海道眼科臨床セミナー

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Industrial Property Rights 9

眼底解析装置及び眼底観察装置

中澤徹

特許5937163

Property Type: Patent
眼科解析装置

中澤徹

特許6374549

Property Type: Patent
眼科解析装置

中澤徹

特許6186454

Property Type: Patent
眼科解析装置及び眼科撮影装置

中澤徹

特許6186453

Property Type: Patent
眼科解析装置及び眼科観察装置

中澤徹

特許5956518

Property Type: Patent
蛍光測定装置及び蛍光測定方法

中澤徹

特許6161693

Property Type: Patent
視神経障害発症リスクの判定方法

中澤徹, 面高宗子, 安田正幸, 田中佑治

特許6338872

Property Type: Patent
眼疾患治療用ナノ粒子製剤

中澤徹

Property Type: Patent
眼科撮影装置

中澤徹

特許6378795

Property Type: Patent

Show all Show first 5

Research Projects 40

認知症・眼疾患用ポータブル低コストハイパースペクトルシステム

シャルマニーラムコーシック, 檜森紀子, 中澤徹, 津田聡, Sharma Parmanand

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2025/04/01 - 2028/03/31
The Role of Lipid Peroxidation in the Pathogenesis of Glaucoma Induced by Obstructive Sleep Apnea

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2025/04/01 - 2028/03/31
新規眼内炎症緩和剤として期待される活性イオウ分子種によるIL1B発現制御機序の解明

俵山寛司, 中澤徹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04/01 - 2027/03/31
GWASによる緑内障感受性遺伝子CDKN2B-AS1のメカニズム解明

面高宗子, 俵山寛司, 中澤徹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04/01 - 2027/03/31
ヒト緑内障GWASからの個別化創薬プラットフォーム構築研究

中澤徹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2024/04/01 - 2027/03/31
グルタチオン三硫化物GSSSGの抗酸化・抗炎症作用に基づく難治性眼疾患の病態制御

國方彦志, 俵山寛司, 中澤徹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2023/04/01 - 2026/03/31
疾患関連マイクログリアクラスター制御による視神経保護治療

大石路子, 佐藤孝太, 中澤徹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2025/03/31
脳MRI定量指標の臨床応用へ：AIを用いた画像駆動型緑内障診断ソフトウェアの開発

舘脇康子, 瀧靖之, 中澤徹, Thyreau Benjamin, 武藤達士, 面高宗子

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

More details Close

緑内障は本邦において推計400万人が罹患する老年病であり、網膜神経節細胞脱落部位に応じた進行性の視野障害を特徴とする。緑内障では網膜だけではなく中枢視路である視神経から大脳視覚野にまで体系的に変性が及び、MRI技術を用いてこれらの変化を詳細に可視化・定量化する試みが行われているが、未だ臨床応用には至っていない。本研究は脳MRI画像から得られる視野障害の程度を反映する定量指標を、客観的な新たな視機能評価法として臨床応用することを目指す。本研究は既存の知見をもとに脳MRI情報から視機能を予測するモデル構築を行い、さらにAIを活用して高精度の診断性能を持つソフトウェア開発を目指したものである。当初、R3年度は100名のテストデータの収集を予定していたが、コロナ感染の収束が見通せず、データ収集は断念した。代わりに、当該年度では既存の緑内障縦断MRIデータベースの約280症例のデータを用いて、画像解析プログラム開発を進めた。まずは、眼科データの充実化を行った。これまでのデータベースに含まれていたMDやOCTによるRNFLTの値だけではなく、網膜に残存する網膜神経節細胞数の推定値であるwRGC（weighted retinal ganglion cell count）の算出を行い、緑内障進行度を示すパラメータとして追加した。wRGCは緑内障の早期から後期にかけての視機能との追従性が良好で、既存のパラメータと比較して緑内障の進行度をより正確にとらえることができると考えられる。次に、画像解析に先立ち、緑内障縦断コホートの解剖学的3D-T1強調画像を対象としてFreesurferにより詳細な灰白質構造の抽出を行い、percellationとsegmentation技術を用いて全脳の解剖学的構造を関心領域とした、各構造の体積と皮質厚データを取得し、視野を推定する数理モデル作成およびAIシステム構築のための準備を行った。
瘢痕化定量技術と薬剤ナノ粒子化による組織移行性の高い濾過胞瘢痕抑制薬の開発

津田聡, 中澤徹, 笠井均, 小関良卓, 佐藤孝太, 國分太貴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31
前眼部組織間のトランスオミクス解析による包括的な眼圧上昇機序の解明

横山悠, 中澤徹, 國分太貴, 矢花武史, 佐藤孝太, 津田聡, 前川重人, 三枝大輔

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

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本研究は緑内障病態理解のため、眼科的臨床データと前房水と線維柱帯のメタボローム解析、プロテオーム解析等を用いた包括的な関連解析を行う研究である。本年度はおもに線維柱帯切開術を行うことを予定された広義原発開放隅角緑内障を対象にサンプル採取を行う計画であった。患者に研究計画を説明し同意を書面上で取得した。手術のための末梢ライン確保時に採血、また同日に検尿を行った上でKahook dual bladeを用いた線維柱帯採取を試みた。しかし、Kahook Dual bladeは新しい型へと変更しており、よりBlade部が小さく改良された。そのため検体採取が手技的に難しくなり、何例がで採取を試みたが検体を得られなかった。現在は旧タイプのKahook Dual bladeの入手は困難となったため、25ゲージ硝子体手術用鑷子、さらにはまだ試用中であったTrabEx+(TM)を用いた線維柱帯採取を試みたが採取部位が非常に小さいこと、出血による視認困難などの理由により。採取できなかった。ほかには代替案として濾過手術など別術式による採取を検討している。濾過手術は虹彩も切除するためより包括的な前房内環境の解析が可能となる。しかし術中、マイトマイシンCなどの薬剤を使用するために解析に何らかの影響を及ぼすことが否定できない。引き続き線維柱帯切開術時、ケリー氏トラベクレクトミーパンチ等別の硝子体手術鑷子等の眼科手術器具を手配して検体採取を行う予定である。
統合解析を用いた網膜神経節細胞別の脆弱性に関わる緑内障障害シグナル伝達経路の探索

面高宗子, 岡田眞里子, 中澤徹, 佐藤孝太

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

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緑内障は成人途失明原因第一位の眼疾患で、本邦は世界に類を見ないスピードで高齢化が進んでおり、今後も緑内障による失明患者数の増加が確実視されている。緑内障の本態は網膜神経節細胞（RGC）の細胞死であるが、現行の治療は眼圧を下降させる治療のみでありアンメットメディカルニーズが存在する。RGC死の詳細なメカニズムを明らかにして、治療薬の開発に繋げていく必要がある。これまでも、げっ歯類を用いた創薬研究は90％以上開発段階で中止となっており、ヒト緑内障の病態を意識した開発が不可欠となる。緑内障では太い軸索を有する大きなRGCが早期から障害され、小さなRGCはミトコンドリア障害に脆弱であることが知られている。本研究では多因子疾患である緑内障のシンプルな障害モデルを作成し、基礎研究技術の進歩を駆使し、緑内障動物モデルにより、げっ歯類RGCをセルソータでサイズ別に分取し、網羅的遺伝子発現解析とメタボローム解析の統合解析から、大小RGCの細胞死シグナルメカニズムを探索する。「動物モデルから統合解析によるプロファイルデータ取得にむけて」マウス障害モデルについて、軸索挫滅・眼圧上昇・酸化ストレス障害モデルに対し、上丘からフルオロゴールド逆行性染色、およびフラットマウントRBPMS抗体免疫染色法により、障害モデルにおける継時的な細胞数の評価を行った。網羅解析に有用な時期は、細胞密度減少の直前とされていることから、それぞれの障害モデルにおいて、サンプル回収に適した時期の同定を行った。続いて、マウス網膜をパパイン酵素処理し、神経細胞を単離し、Thy1.2抗体によりRGCをラベル、細胞サイズでゲートをかけ、セルソータによるRGCの細胞サイズによるカウントと分取を行った。障害後の複数のタイムポイントで、生存するRGCをサイズ別に検討し、障害の種類により、RGCの大小で脆弱性が異なることを検討した。
炎症性眼疾患の治療・緩和を見据えた活性イオウ分子種による抗炎症作用機序の解明

俵山寛司, 中澤徹, 國方彦志

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31
Development of neuroprotective therapy targeting retinal glial cells

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2021/04/01 - 2024/03/31
Retinal optic nerve regeneration by human iPS cell-derived retinal ganglion cells and artificial sieve plate transplantation

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2021/07/09 - 2023/03/31
CRISPRスクリーニングによる緑内障感受性遺伝子の同定

中澤徹, 小林航, 佐藤孝太

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(B)

Category: 基盤研究(B)

Institution: 東北大学

2020/04/01 - 2023/03/31

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緑内障は本邦の中途失明原因第一位の眼疾患である。病態は多因子疾患であるにも関わらず、眼圧下降治療しか存在せず、眼圧下降治療後も視野欠損が進行する症例が40％認め、アンメットメディカルニーズが存在する。そのため、緑内障の眼圧以外の病態を明らかにし、病態特異的治療の開発が急務である。緑内障には遺伝的要因があり、ゲノムワイド関連解析（GWAS）により複数の緑内障関連SNPが同定されている。しかし、病態との因果関係について十分に検討されていない。そのため本研究では、神経保護治療のターゲットとなる網膜神経節細胞の脆弱性に寄与する遺伝子変異とそのメカニズムを同定することを目的とした。本年度は、臨床パラメータとSNP情報を関連解析するための検査データセットを構築した。また、GWASにより同定されたゲノムワイド有意水準を超えるSNPならびにその近傍にある遺伝子について調査し、CRISPRスクリーニングの対象とする遺伝子について精査した。加えて、近年報告された国際コンソーシアムによる緑内障GWASから計算されたpolygenic risk scoreの利用を念頭においた解析準備を進めた。基礎研究では、緑内障関連遺伝子の表現型を評価するための細胞株を選定し、細胞培養条件や緑内障病態を反映するストレス負荷条件（酸化ストレス、興奮毒性、炎症、低栄養、低酸素）について検討した。
エピゲノム編集による抹消血を用いた網膜色素変性病因遺伝子の発現解析法の開発

西口康二, 中澤徹, 藤田幸輔

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2020/04/01 - 2023/03/31

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本研究では、網膜色素変性患者由来の不死化リンパ球を対象に、ゲノム編集技術を用いて特定のRP病因遺伝子のプロモーターを非メチル化することにより同遺伝子の強制発現細胞株の樹立を可能にする技術を開発することを目的とした。まずは日本人網膜色素変性患者の病因遺伝子として最も頻度が高いEYS遺伝子を開発対象とした。同遺伝子のプロモーター配列をゲノム編集を用いて非メチル化したところ、それ単独ではEYS発現は誘導されなかった。しかし、この細胞に対して脱メチル化剤を添加することによってEYS発現が検出された。我々はさらに効率的な手法を樹立する目的でCRISPR activationを用いた遺伝子強制発現法の開発に着手した。 EYS転写開始点をカバーするようにgRNAを複数デザインし、それらをCRISPR activationに用いた。この方法でHEK293Tやリンパ芽球でEYSの発現の誘導に成功した。我々は、患者由来のリンパ芽球細胞株を用いて、本来リンパ球では発現しない網膜色素変性病因遺伝子のmRNA発現解析を行い、同患者のゲノム情報と照合することにより、逆算的に病因変異の同定可能であることを確認した。このアプローチの基本的有用性が明らかになったため、この方法を改良することで比較的簡便かつ安価な遺伝子診断補助検査法の開発を目指している。具体的には、末梢血から単核球分画を分離し、CRISPR activationを用いてそれらの細胞でEYSの遺伝子発現解析を行う。現時点では、分離した単核球に対して蛍光遺伝子を導入し、培養条件を設定中である。
マルチモーダルAIを用いた視覚指標による幸福度評価

中澤徹

Offer Organization: 科学技術振興機構

System: 戦略的な研究開発の推進未来社会創造事業探索加速型

Institution: 東北大学

2021 - 2023

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外界情報の約 8 割を担うとされる視機能の低下は、生活の制限や自立という観点から幸福度に大きく影響する。視機能障害者、特に治療での回復が望めない患者のウェルビーイング向上は社会的に極めて重要である。他者の補助だけでは不十分であり、「能動的に行動することによる達成感」の獲得を補助するデジタルデバイスの開発が重要課題であると考える。その足掛かりとして、視覚情報に重点を置いた新規の主観的ウェルビーイング評価法を確立することに加え、生理検査データ、表情、音声などから個人の最適化状態を定量的に把握する方法を、機械学習を組み合わせることで視機能障害の観点から開発することを試みる。また、生体情報を反映するバイオマーカーを探索し科学的根拠に基づくウェルビーイング指標を構築する。将来的には、生活習慣の改善に繋げる行動変容を促し生涯にわたり視機能を維持することで、社会における利他の実現に向けた貢献を目指す。
Pathological analysis of chimeric mice using human iPSCs derived from glaucoma patient with gene mutations

Nakazawa Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2019/06/28 - 2021/03/31

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It is now possible to generate three-dimensional retinal organoids from human iPSCs and to isolate and culture retinal ganglion cells (iPS-RGCs) from the organoids. However, in vitro studies cannot reproduce the intraocular environment, so we decided to transplant human iPS-RGCs into the eyes of rodents to study the factors involved in their survival in vivo. In this study, we generated GFP-labeled human iPS-RGCs by genome editing using CRISPR/Cas9, which was difficult by MMEJ method. The fluorescence labeling will facilitate future studies using imaging and sorting.
Development of a novel CRISPR-Cas9 vector for functional analysis of retinal disease-related genes

Fujita Kosuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

2018/04/01 - 2021/03/31

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Based on the miniaturization of each part required for genome editing, we developed a single AAV platform that can locally replace mutant sequences with wild-type counterparts. In blind mice, the mutation replacement rescued approximately 10% of photoreceptors, resulting in increased visual acuity to approximately 60% of controls. Surprisingly, these effects were comparable to recovery mediated by photoreceptor-targeted gene supplementation. This strategy paves the way for the treatment of hereditary disorders caused by mutations in larger genes where traditional gene replacement therapies are not currently feasible.
Development of a HDAC1/2 inhibitor K560-mediated treatment for glaucoma

Tawarayama Hiroshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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Retinal ganglion cell (RGC) death is the symptom of glaucoma. It is thought that oxidative stress partially contributes the cell death. In this study, we investigated the effect of K560, an isozyme selective inhibitor of histone deacetylase (HDAC) 1/2, on oxidative stress-induced RGC death, and found that (1) K560 attenuated oxidative stress-induced death of dissociated retinal cells in mice, (2) K560 enhanced histone acetylation of retinal lysates prepared from mice administered with K560 intravitreally, (3) K560 inhibited oxidative stress-induced RGC death in mice. These findings suggested that K560 administration is a promising treatment for glaucoma.
We investigate the neuroprotective mechanisms in glaucoma against oxidative stress, the Keap1/Nrf2 pthway.

Himori Noriko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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Mitochondria are known as one of the endogenous reactive oxygen species producing organs. Mitochondrial damage and oxidative stress are thought to be closely related. It was revealed that retinal Mueller cells are activated in Nrf2 knockout mice that are vulnerable to oxidative stress when mitochondrial damage is caused by the Complex I inhibitor rotenone. Rotenone was added, and we investigated the difference in neuroprotective factor / antioxidant enzyme secretion mechanism between Nrf2KO mice and wild-type mice. There is a significant increase in neuroprotective factors in the Mueller cells of Nrf2KO mice as compared with the wild type.
Construction of integrated glaucoma database and discovery of glaucoma biomarker by metabolomics

Nakazawa Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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Human samples were analyzed for the purpose of primary selection of powerful biomarker candidates by metabolomics. Comprehensive metabolomics were performed using samples of anterior chamber fluid, peripheral blood, and urine of patients from open-angle glaucoma. As a control group, samples from patients with cataract, preretinal membrane and macular hole were used. The anterior chamber fluid, blood, and urine samples were collected from the same patient. As a result of analyzing 34 cases in the glaucoma group and 37 in the control group, the metabolites varying in the glaucoma group was extracted by the principal component analysis and the discriminant analysis. Furthermore, correlation between the amount of metabolites in the anterior chamber fluid and clinical parameters such as MD value and axial length was investigated, and several metabolites that correlated with each parameter were found.
Comparison of plasticity between rod and cone visual pathways

Nishiguchi Koji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2016/04/01 - 2019/03/31

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Mice defective of Pde6c and Gnat1 resulting in congenital lack of cone and rod function are virtually blind from birth. In this study, we treated mice of different ages by supplementing GNAT1 gene followed by assessment of visual recovery. As a result, the levels of functional restoration measured at the retina and visual cortex were not significantly different between mice treated at 1M, 3M, and 9M following GNAT1 gene supplementation therapy. Moreover, visual restoration at the level of visual cortex were similar to mice with only Pde6c defect. The results indicate that rod visual pathway in adult mice retain substantial plasticity.
Evaluation of the correlation between structure and function and cognitive impairment, and assessing diagnosis and progression in older patients with glaucoma.

HONJO MEGUMI, Aihara Makoto, Asaoka Ryo, Nakazawa Toru, Kurano Makoto, Yamagishi Reiko, Uchida Takatoshi, Araki Yuka, Terao Ryo, Igarashi Nozomi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: The University of Tokyo

2015/04/01 - 2019/03/31

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The correlation between structure and function was significant, and objective and quantitative method with OCT assessing glaucoma that does not require patient ability could be a possible parameter to assess diagnosis and progression in older patients with glaucoma. A high prevalence of MCI or dementia was observed in the elderly population, and the squared prediction error of perimetry increased with decreasing MMSE total score, but age, FL, FP, and FN were not related. The presence of glaucoma in iNPH was high, and the cupping depths of the discs of NTG patients with iNPH were significantly shallower compared with those of NTG patients without iNPH. ATX-LPA pathway was up-regulated in secondary glaucoma or exfoliation glaucoma, and the potentially important role of the ATX-LPA pathway for IOP regulation and fibrosis after glaucoma surgery was suggested.
Improvement effect of tokishyakuyakusan for fundus circulation in normal tension glaucoma

Takayama Shin

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2014/04/01 - 2019/03/31

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Thirteen healthy subjects received 3 kinds of kampo medicine. Tokishyakuyakusan increased fundus circulation. Nineteen healthy subjects received tokisyakuyakusan. The fundus circulation significantly increased fundus circulation from 30 minutes to 60 minutes compared with water drinking alone. Eleven patients of normal tension glaucoma received tokisyakuyakusan added to conventional treatment. Fundus circulation did not significantly change after 6 months administration.
In vivo imaging of retinal ganglion cell function using adeno-associated virus

Nakazawa Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2016/04/01 - 2018/03/31

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Glaucoma, a leading cause of blindness worldwide, is characterized by progressive loss of the retinal ganglion cells (RGCs). To study neuronal activity in pathogenesis of RGC death, we developed in vivo imaging for quantitating activities of neuronal activity. E-SARE drives neuronal activity dependent gene expression at high levels. The E-SARE-driven fluorescent protein reporters was packaged into AAV. The temporal activity was monitored using confocal ophthalmoscopy. Dark-adapted animals were kept in dark for 48 hours before use. Light-adapted animals were kept under a constant light for 6 hours after dark-adaptation for 48 hours before use. E-SARE reporter expression was induced by light stimulation, and localized in RGC. Increased reporter activity occurred by 2 hours after light stimuli, and decreased at 2hours after dark-adaptation showing 44% decreases. This E-SARE reporter in vivo cellular imaging is a usuful tool to assess the RGCs function in retinal diseases.
Investigation of the onset mechanism of primary open-angle glaucoma -Genetic investigation of the mechanism of intraocular pressure elevation-

MABUCHI Fumihiko, KUWABARA Ryoko, YOSHIZAWA Satoko, MABUCHI Nakako, KUME Atsuki, IIJIMA Hiroyuki, YAMAGATA Zentaro, TAKMOTO Mitsuko, AIHARA Makoto, IWATA Takeshi, SHIGA Yukihiro, NISHIGUCHI Koji, NAKAZAWA Toru, KAWASE Kazuhike, OZAKI Mineo, ARAIE Makoto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: University of Yamanashi

2015/04/01 - 2018/03/31

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This study was performed to investigate the association between the additive effects of intraocular presure (IOP)-related genetic variants and maximum IOP, vertical cup-to-disc ratio (VCDR), and high tension glaucoma (HTG) or normal tension glaucoma (NTG) as phenotypic features of POAG. As the total number of risk alleles of IOP-related genetic variants increased, the maximum IOP and VCDR significantly increased. The IOP and VCDR were increased by the additive effects of IOP-related genetic variants in POAG, and the phenotype (HTG or NTG) in POAG depends on the additive effects of IOP-related genetic variants.
Examining feasibility of brain MRI as an objective diagnostic biomarker for glaucoma

Tatewaki Yasuko, Nakazawa Toru, Omodaka Kazuko, Tomita Hiroaki, Ono Chiaki, Kasahara Yoshiyuki, Matsudaira Izumi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2014/04/01 - 2018/03/31

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We have been conducted longitudinal data aquisition and have analyzed cross-sectional data including mainly anatomical 3D-T1WI images and clinical visual field information, MD(mean deviation). Voxel-based regressing analysis with SPM12(Statistical Parametric Mapping software 12) revealed that gray matter volume of the specific region in primary visual cortex could correspond to the degree of glaucoma-related visual field loss. Patients with glaucoma are often unaware of their visual field loss because that glaucoma-related visual sensitivity loss starts from periphery of visual field. Our results could be of clinical use for picking up asymptomatic glaucoma by detecting specific atrophy via brain MRI medical checkup.
Research for blood RNA marker predicting prognosis of glaucoma focusing on the early and individualized medicine.

Nakazawa Toru, ITO Masayoshi, KAWAJI Hideya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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Glaucoma is a chronic ocular disease that is often influenced by high intraocular pressure, resulting in irreversible loss of visual field. Visual field loss caused by glaucoma is progressive, thus, we should diagnose glaucoma at its early stages and start the treatment if indicated. The goal of the present study is to identify biomarkers for glaucoma, through investigating the translational profiles of RNA derived from blood. Thirty-two patients with normal tension glaucoma and 32 controls with ocular diseases which have little association with genetic factors were recruited in the present study. RNA was extracted from the peripheral blood. Activation of promoters of all the genes were comprehensively quantitated using cap analysis gene expression (CAGE) technique. We selected the candidate genes as biomarker according to the result of the differential analysis of the two groups. The promoters identified hold promise for their clinical application as biomarkers for glaucoma.
Creation of novel drug nanoparticles based on the conventional reverse molecular design using poor water-soluble compounds and the efficacy evaluation

KASAI HITOSHI, OIKAWA Hidetoshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2013/04/01 - 2017/03/31

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In this project, we introduced a new concept of introducing a poorly water-soluble substituent into anticancer medicinal compounds. Next, we synthesized them and then created the drug nanoparticles by using our own technique of the reprecipitation method. And, it was found that, by covering polymers or proteins on these drug nanoparticles, dispersion stability of the nanodrug could be improved. In vivo experiment, it was revealed that the nanodrugs could be delivered into the inside of cells of the tumor tissue. And this technique could be applied as eye drops including the glaucoma and so on.
Analysis of intarocular antioxidant and development of intraocular irrigating solution

Nakazawa Toru, Kunikata HIROSHI, Ida TOMOAKI, Akaike TAKAAKI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2014/04/01 - 2016/03/31

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We found that there were reactive persulfides and polysulfides in blood, aqueous humor and vitreous in diabetic eyes as well as controls. Furthermore, the concentration of some persulfides was different between diabetic eyes and controls, and there were some correlations between the persulfides in aqueous humor and vitreous.
Elucidation of neuroprotective effect of calpaan inhibitor in retina and central nerve systems in the model of glaucoma

Ryu Morin, Moritou Satoru, Nakazawa Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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AAPH administration was an effective model of oxidative stress-induced glaucoma, showing that oxidative stress directly activated the calpain pathway and induced RGC death in mice retina. Furthermore, inhibition of the calpain pathway protected the RGCs after AAPH administration. In our study, suppressing calpain activation reduced RGC death, suggesting that it may be a good candidate for neuroprotection therapy.
Relationship between dendritic localization of inhibitory synapses and visual information processing in mammalian retinal ganglion cells

KOIZUMI Amane, NAKAZAWA Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: National Institute for Physiological Sciences

2012/04/01 - 2015/03/31

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We successfully applied organotypic adult retina culture system with gene-gun to marmoset retina. Especially, we introduced GFP plasmid into marmoset retinal ganglion cells, and found a morphological diversity of retinal ganglion cells beside well-known midget and parasol ganglion cells. In addition, we introduced PSD95-GFP, synaptic maker, plasmid into retinal ganglion cells and analyzed dendritic localization pattern of synapses in different subtypes of retinal ganglion cells. By this method, we found narrow thorny retinal ganglion cells almost exclusively receive synaptic inputs from DB6 bipolar cells, and project into K1 layer of lateral geniculate nucleus.
Development of retinal treatment with dental pulp cells

NAKAZAWA Toru, TANAKA Yuji, SASAKI Ryo

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2012/04/01 - 2014/03/31

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The transplantation of dental pulp-derived cells to the eye was explored for the possibility of the novel neuroprotection and regenerative treatments to the critical retinal diseases that results in vision loss. Firstly, the isolated dental pulp-derived cells were directly injected into normal rat vitreous, and it was confirmed that some of the injected cells adhered to the retina and formed the neuronal process. Furthermore, several cell manipulation methods were examined to enrich stem cell population and up-regulate neuron-related molecular expression. Specifically, (1) gene expression of nerve and stem cell related molecule were activates by sphere-forming floating culture, (2) sphere-forming cells can be enriched by cell sorting of CD105-positive dental pulp-derived cells, (3) the expression of an axonal regeneration related molecule was promoted by applying hypoxic culture to the sphere-forming culture.
3D眼底形状イメージングによる簡易的な緑内障リスク評価システムの構築

中澤徹

System: 産学が連携した研究開発成果の展開復興促進プログラムマッチング促進

Institution: 株式会社トプコン

2012 - 2014
Development of an integrated neuroprotective treatments in glaucoma

NAKAZAWA Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2010 - 2011

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The glaucoma is an eye disease that is the primary cause of vision loss in Japan, and its prevalence rate is still increasing. Although high intraocular pressure was an important risk-factor in glaucoma, in this research, the clinical validity of the ocular fundus blood flow evaluation in glaucoma diagnosis, participation of the oxidant stress defense mechanism and calpain to control of mouse retinal ganglion cell death, and mouse retinal ganglion cell protection ability of antioxidants and calpain inhibitor were newly clarified. These results will be important for pathological elucidation, an early detection, and development of nerve protection treatments in the field of glaucoma.
ナノ粒子を用いた貪食細胞特異的治療の開発

中澤徹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的萌芽研究

Institution: 東北大学

2009 - 2010

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ステロイド(デキサメサゾン、DEX)含有ナノ粒子(DEX-NP)の炎症抑制効果は、生体では週令の雄SD-rat使用して、病態(NMDAモデル、網膜剥離モデル)眼に投与し、治療効果(FluoroGoldで逆行性染色した網膜神経節細胞の生存数を数えること、視細胞のTUNNEL染色陽性細胞を数えること)を確認した。培養細胞においては、初代培養したマクロファージにDEX-NPを投与し、qRT-PCRで炎症(TNFα、MCP1)抑制効果を定量した。 DEX-NP(13μg/ml、DEX0.65μg/ml相当)の治療効果について、培養マクロファージに対してステロイド(DEX)単独投与(0.65μg/ml)と同等の炎症抑制効果、そしてより長期間(2日間まで)に効果が持続したことを、TNFα MCP1のmRNA発現で確認した。生体では、NMDA病態モデルに対してミクログリア活性化の抑制、網膜神経節細胞(RGC)のapoptosisの抑制効果を認めた。網膜剥離モデルに対して、視細胞のapoptosisを抑制できた。これまでに網膜剥離、緑内障、網膜虚血、ぶどう膜炎、脈絡膜血管新生の動物モデルにおいて、マクロファージ、ミクログリアの神経毒性を報告してきたことから、網膜疾患の神経保護治療に有効な可能性がある。ステロイドはその薬効から臨床的に良く用いられているが、意図しない副作用(緑内障、白内障)のために慢性疾患には長期投与が難しい。マクロファージとミクログリアに特異的に薬剤伝達できれば、免疫抑制以外の副作用が軽減できる。本研究で使用したナノ粒子がマクロファージ、ミクログリアへ取り込まれる特性を利用して、薬剤をターゲット細胞特異的に運搬し、副作用を抑えた新しい眼内投与法の開発が期待できる。
Neuroprotective treatment for glaucoma

NAKAZAWA Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2007 - 2008
Development of regenerative therapy for corneal endothelial diseases

NISHIDA Koji, MAEDA Naoyuki, TANO Yasuo, YAMATO Masayuki, NAKAZAWA Toru, YOKOKURA Syunji, KUBOTA Akira

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2006 - 2008
網膜色素上皮細胞による網膜下腔イオン環境制御機構の解明

志村雅彦, 中澤徹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2003 - 2004

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加齢黄斑変性症や網膜色素変性症などの網膜難治疾患に対して、主たる病変部位である網膜色素上皮細胞(RPE)の生理機能を細胞レベルでとらえる研究を進め、網膜色素上皮細胞に存在する内向き整流性カリウムチャネルKir7.1が網膜下腔のイオン環境の維持に大きな役割を果たしていることを電気生理学的に示すことが前回の研究で明らかになったが、今回はその局在を調べるためにKir7.1ポリクローナル抗体をミシガン大学ブレットヒューズ博士より提供され、Na-K ATPaseの局在もあわせて、組織免疫染色法にて同時に検討した。これよりブタ網膜色素上皮細胞ではKir7.1およびNa-K ATPaseがともに網膜色素上皮細胞の突起側に局在していることが判明した。同時に毛様体色素上皮細胞では無色素上皮細胞にのみ局在しており、色素上皮には存在が認められなかった。このことはKir7.1とNa-K ATPaseが主にカリウムイオンの排出が網膜、あるいは硝子体へと移動するのに重要な役割を果たしていることが示唆された。毛様体無色素上皮細胞を単離し、パッチクランプ法にて膜コンダクタンスを検討したところ、過分極での内向き整流性と同時に、クロライドチャネルと思われる脱分極相での外向き整流性電流も認められた。今回の毛様体無色素上皮細胞でのこれらの発現は、房水産生との関連性を強く疑わせるものであり、今後の緑内障研究につながるものと期待される。

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Social Activities 35

第8回元気！健康！フェアinとうほく

2016/04/02 - 2016/04/03

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講演「9割の人が気づけない目の病気～緑内障の対策と治療」
第７回元気！健康！フェアinとうほく

2015/04/04 - 2015/04/05

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基調講演「見える喜びいつまでも～知っておきたい緑内障の最新情報～」
「人工知能による高精度緑内障自動診断-マルチモダリティ情報を用いた機械学習で緑内障の客観的診断に貢献-」

東北大学プレスリリース

2019/03/28 -
高純度なヒトiPS細胞由来網膜神経節細胞の作製－緑内障の根本原因の解明を目指す－東北大学大学院医学系研究科、東北大学プレスリリース

2018/03/27 -
研究進む緑内障眼圧上昇に加え生活習慣と加齢関与か関連遺伝子解析も京都新聞

2018/03/27 -
緑内障の原因ストレス、遺伝が関係働き盛りは定期検診を上毛新聞

2018/03/19 -
前視野緑内障経過見て治療神経の状態定期的に検査日本経済新聞

2018/03/12 -
開放隅角緑内障に関わる新たな7遺伝子領域を同定‐1万5,000人の緑内障患者のゲノム解析から病因の解明へ‐東北大学大学院医学系研究科、東北大学プレスリリース

2018/02/19 -
緑内障の遺伝要因と臨床的特徴との関連を解明東北大学大学ジャーナル

2018/01/10 -
山梨出身の医師失明ゼロめざす、東北・被災地で実績

2017/12/31 -
緑内障の視神経乳頭形状の自動分類 ‐機械学習モデルで緑内障の診断に貢献‐

2017/12/27 -
抗酸化力と緑内障重症度との関係を解明

2017/08/21 -
緑内障治療薬の候補発見、ヘスペリジンで視力低下抑制東北大

2017/08/04 -
ミカンのポリフェノールによる緑内障治療の可能性を示唆‐ヘスペリジンは網膜細胞障害において神経保護作用を持つことを発見‐

2017/08/01 -
トプコンが朝安後切り返す、東北大と協力し緑内障分類を自動で行うソフトウェアを開発

2016/08/26 -
緑内障の原因自動で分類東北大など、ソフト開発

2016/08/26 -
トプコン、東北大と緑内障分類の自動化方法を開発

2016/08/26 -
緑内障の個別化医療に一手、東北大とトプコン

2016/08/25 -
東北大とトプコン、緑内障分類を自動で行うソフトウェアを開発

2016/08/25 -
東北大とトプコン、緑内障分類の自動化方法を開発

2016/08/25 -
世界初：緑内障分類の自動化方法の開発 ‐多様な緑内障病態の細分化、個別化医療への足がかりへ‐

2016/08/22 -
目の健康講座

2015/05/16 -

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宮城県眼科医会主催
健康情報・緑内障 NHKマイあさラジオ東北

2015/04/17 -

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緑内障の病気について
蛍光色素の新試薬を開発

2013/10/25 -
市民公開講座

2013/10/20 -

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目からウロコの眼科トピックス講演
緑内障治療神経保護で新アプローチ

2013/06/21 -
東日本大震災における被災地眼科巡回診療の総括

2012/11/10 -

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東日本大震災における被災地眼科巡回診療の総括
[日本国内] 糖尿病網膜症の進行、薬で制御

2012/10/23 -
[日本国内] 初期症状薬で進行抑制

2012/09/05 -
第4回元気！健康！フェアinとうほく

2012/04/29 -

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東北大学、華北新聞社TBC東北放送主催の健康フェア 34名に及ぶ講師軍に良く健康セミナー交流会企業展示プレゼンテーションを開催
酵素阻害薬の神経保護効果を確認緑内障の新治療法開発へ。

2012/01/16 -
緑内障治療について

2011/11/28 -
緑内障治療の新たな光明投薬で視神経を保護

2011/11/27 -
東北大、カルパイン阻害剤が緑内障の治療に効果あることを確認

2011/09 -
家庭の医学番組出演

2007/09/19 -

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白内障をテーマに３０分の収録をした

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Media Coverage 33

関連病院とのコンサルトにMMWIN眼科連携が活用されています Myself

MMWIN NEWS

2021/09/24

Type: Promotional material
人生100年時代をこの眼と生きる

河北新報

2019/11/14
健康の医学教室「実は身近な緑内障」

河北ウイークリーせんだい

2019/09/12

Type: Newspaper, magazine
「目からウロコの眼科の話」「冷え症、やせ型、完璧主義…緑内障になりやすいのは？」

第１１回元気・健康フェアinとうほく仙台

2019/04/06

Type: Other
緑内障の早期発見・治療をアピール3月10日から啓発ライトアップ

河北新報社

2019/02/28

Type: Newspaper, magazine
緑内障の視神経障害と関連するバイオマーカーの同定

艮陵新聞

2018/10/31
緑内障と向き合う知恵 NHKガッテン住友生命版 2018 10月号主婦と生活社

2018/10
眼科医療の最前線 NHK World Medical Frontiers

2018/09/11
高純度なヒトiPS細胞由来無膜神経節細胞の作製－緑内障の根本原因の解明へ－東北大学広報誌「まなびの杜」2018夏号

2018/06/30
医療特集「治る！最前線」「緑内障の最新治療」テレビ東京 WBS（ワールドビジネスサテライト）

2018/06/25
眼圧が下がっても進行する緑内障には酸化ストレスの抑制が有効壮快 2018年6月号

2018/06
緑内障研究進む習慣や加齢、遺伝影響か眼圧上昇以外にも要因宮崎日日新聞

2018/05/03
生活習慣や加齢緑内障の要因に眼圧下げても病状悪化秋田さきがけ

2018/04/07
緑内障…研究の現状は専門家に聞く生活習慣、加齢も影響か産経新聞

2018/04/06
テーマ：緑内障！こんなタイプは要注意だ

ＮＨＫ総合「ガッテン！」

2017/04/12

Type: TV or radio program
東日本大震災を経験して学んだこと

2013-2015 ビジョンバン活動報告集

2016/08/20

Type: Newspaper, magazine
CRIETOの部門紹介 No.10 広報部門中澤徹部門長インタビュー

東北大学病院臨床研究推進センター広報誌CRIETO Report Summer2016 Vol.11

2016/07/29

Type: Newspaper, magazine
「9割の人が気づけない目の病気～緑内障の対策と治療」第8回元気！健康！フェアinとうほく

河北新報朝刊

2016/05/30

Type: Newspaper, magazine
第8回元気！健康！フェアin とうほく講師紹介

河北新報新聞朝刊

2016/03/28

Type: Newspaper, magazine
東北大学医学部眼科学教室ごあいさつ

河北新報新聞朝刊

2016/02/29

Type: Newspaper, magazine
患者急増失明原因1位に

河北新聞

2015/07/01

Type: Newspaper, magazine
見える喜びいつまでも～知っておきたい緑内障の最新情報～

河北新聞新報朝刊

2015/04/16

Type: Newspaper, magazine
スーパ-Jチャンネルみやぎ

2015/02/03

Type: TV or radio program

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東北大学広報誌「hesso」が取り上げられ、眼科医長・広報室長の中澤教授、総合地域医療教育支援部部長石井正教授が出演
[日本国内] 東北研究者一層の進歩への励み

河北新報

2012/10/10

Type: Newspaper, magazine
[日本国内] 緑内障

TBCラジオ

2012/10/05

Type: Other
[日本国内] 加齢黄斑変性

TBCラジオ

2012/09/28

Type: Other
[日本国内] 酵素阻害薬の神経保護効果を確認緑内障の新治療法開発へ

東北大学新聞

2012/01/16

Type: Newspaper, magazine
東北大、カルパイン阻害剤が緑内障の治療に効果あることを確認

マイナビニュース

2011/09

Type: Other
：世界緑内障週間！ライトアップ in グリーン運動

マイあさラジオ東北7：40〜NHKラジオ第一

Type: TV or radio program
朝日放送テレビ名医とつながる！たけしの家庭の医学

朝日放送テレビ名医とつながる！たけしの家庭の医学

Type: TV or radio program
第28回日本日本緑内障学会Meeting Report シンポジウム６血流 Frontiers in Glaucoma2018

第55号メディカルレビュー社
見える幸せいつまでも～失明ゼロを目指して/実は身近な緑内障～早く気付いて上手に付き合おう

元気！健康！フェアinとうほく宮城の医療と健康 vol.6(2018-2019)
Clinical and Experimental Ophthalmology Reviewer Certificate; for participating in the peer-review process as a reviewer for papers submitted between 1 Aug. 2016 and Jul. 2017 to Clinical and Experimental Ophthalmology

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Other 5

糖尿病眼症における網膜神経節細胞死の機序解明と神経保護治療の開発

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糖尿病眼症における網膜神経節細胞死の機序解明と神経保護治療の開発
軸索流障害における網膜神経節細胞死の機序解明

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軸索流障害における網膜神経節細胞死の機序解明を行う
マウス高眼圧モデルの神経保護に関する研究

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マウス高眼圧モデルの神経保護に関する研究
糖尿病眼疾患の神経保護治療

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糖尿病眼疾患の神経保護治療
ナノ粒子の臨床応用

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ナノ粒子の臨床応用