Details of the Researcher

PHOTO

Kazutaka Jin
Section
Graduate School of Medicine
Job title
Associate Professor
Degree

  • 医学博士 (Tohoku University)

e-Rad No.
20436091

Research History 5

  • 2015/04 - Present
    Tohoku University Graduate School of Medicine　Department of Epileptology　Associate Professor

  • 2011/04 - 2015/03
    Tohoku University Graduate School of Medicine　Department of Epileptology　Lecturer

  • 2010/07 - 2011/03
    東北大学大学院運動機能再建学分野　助教

  • 2006/04 - 2010/06
    東北大学大学院神経内科学分野　助教

  • 2007/09 - 2010/03
    Cleveland Clinic Epilepsy Center　Research fellow

Education 1

  • Tohoku University　Faculty of Medicine　School of Medicine

    1990/04 - 1996/03

Committee Memberships 9

  • 日本臨床神経生理学会　理事

    2025 - Present

  • 日本てんかん学会　理事

    2021 - Present

  • 日本臨床睡眠医学会（ISMSJ）　評議員

    2020 - Present

  • 国際臨床脳磁図学会　理事

    2019 - Present

  • 日本てんかん学会　ガイドライン作成委員会 委員

    2018 - Present

  • 日本臨床神経生理学会　代議員

    2017 - Present

  • 日本神経学会　てんかん診療ガイドライン作成委員会 委員

    2014 - Present

  • 日本てんかん学会　評議員

    2013 - Present

  • 国際臨床神経生理学会（ICCN）　「長時間ビデオ脳波モニタリング検査の最低基準」 ガイドライン作成ワークグループ メンバー

    2018 - 2021

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Professional Memberships 11

  • 日本臨床睡眠医学会（ISMSJ）(2013/08-)

  • 日本睡眠学会(2013/08-)

  • 国際臨床脳磁図学会(2007/04-)

  • アメリカてんかん学会(2010/12-)

  • 日本生体磁気学会(2006/04-)

  • 日本てんかん学会(2005/04-)

  • 日本臨床神経生理学会(2000/04-)

  • 日本神経治療学会(2000/04-2007/09)

  • 日本神経感染症学会(1996/04-2007/09)

  • 日本内科学会(1996/04-)

  • 日本神経学会(1996/04-)

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Research Interests 10

  • デジタルバイオマーカー

  • 多遺伝子リスクスコア

  • 高齢発症てんかん

  • 高次脳機能障害

  • magnetoencephalography

  • electroencephalography

  • sudden death

  • autonomic nervous system

  • sleep

  • epilepsy

Research Areas 2

  • Life sciences / Neurosurgery /

  • Life sciences / Neurology /

Awards 3

  1. 令和4年度医学部奨学賞金賞

    2023/01　東北大学医学部

  2. 令和2年度医学部・医学系研究科教育貢献賞

    2021/03　東北大学大学院医学系研究科

  3. 研究褒賞

    2016/03　てんかん治療研究振興財団　てんかん発作時の自律神経モニタリングと包括的てんかん診断

Papers 134

  1. Impact of pre-graduation transition on psychosocial outcomes in childhood-onset focal epilepsy

    Maimi Ogawa, Kazushi Ukishiro, Kazutoshi Konomatsu, Takafumi Kubota, Mayu Fujikawa, Fuka Otomo, Yosuke Kakisaka, Nobukazu Nakasato, Kazutaka Jin

    Epilepsy & Behavior　177　110930-110930　2026/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.yebeh.2026.110930 　

    ISSN： 1525-5050

  2. Assessment of memory lateralization by posterior cerebral artery selective anesthesia and postoperative verbal memory decline. International-journal Peer-reviewed

    Hana Kikuchi, Kazuo Kakinuma, Shin-Ichiro Osawa, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Shiho Sato, Shunji Mugikura, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Journal of neurosurgery　1-8　2025/12/05

    DOI： 10.3171/2025.8.JNS25878 　

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    OBJECTIVE: The Wada test, an intracarotid amobarbital procedure, is the gold standard for preoperative evaluation of postoperative memory decline in patients with drug-resistant epilepsy. However, it has certain limitations including false negatives due to insufficient hippocampal inhibition and false positives due to extrahippocampal disorders such as aphasia. This study examined the utility of posterior cerebral artery (PCA) selective anesthesia for functional evaluation (SAFE) as an alternative approach to avoid aphasia and assessed its predictive value for postoperative verbal memory decline. METHODS: The authors conducted a single-center retrospective study of patients with drug-resistant epilepsy between May 2018 and December 2023, who subsequently underwent PCA SAFE before anterior temporal lobe resection. The SAFE protocol includes comparable memory tasks before and immediately after anesthetic infusion. Preinfusion assessments established baseline memory function, whereas postinfusion assessments evaluated brain function under selective anesthesia. Patients were required to memorize 8 words, 8 pictures, and 5 figures. After the anesthetic effects subsided, recognition tasks were performed for all presented stimuli. The memory score was calculated by subtracting the number of recognized items encoded under anesthesia from the baseline. Word recognition represented verbal memory, whereas figure recognition represented visual memory. A memory score ≥ 2 points on the side of the epileptic focus or no difference between left and right PCA SAFE was classified as a high risk of postoperative memory decline. A decline of ≥ 15 points in postoperative memory scores on the Wechsler Memory Scale-Revised was defined as significant memory decline. RESULTS: The authors included 11 patients (focus side: left in 8 patients and right in 3 patients). Five patients were classified as having a high risk and 6 as having a low risk for verbal memory decline. All 5 high-risk patients revealed significant postoperative verbal memory decline, whereas 5 of the 6 low-risk patients did not. The sensitivity was 83.3%, and the specificity was 100%. No patients had a significant decline in postoperative visual memory. CONCLUSIONS: PCA SAFE was shown to predict postoperative verbal memory decline with high accuracy. This study highlights the utility of PCA SAFE in reducing aphasic interference in verbal memory, leading to a more accurate evaluation of surgical candidacy in patients with drug-resistant epilepsy.

  3. Visualizing diagnostic delays in functional/dissociative seizures using the referral odyssey plot: A retrospective cohort study. International-journal Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Maimi Ogawa, Mayu Fujikawa, Makoto Ishida, Takafumi Kubota, Kazushi Ukishiro, Nobukazu Nakasato, Masashi Aoki, Kazutaka Jin

    Seizure　133　61-67　2025/12

    DOI： 10.1016/j.seizure.2025.10.009 　

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    BACKGROUND: Functional/dissociative seizures (FDS) are often misdiagnosed as epilepsy, leading to delays in appropriate interventions. Although certain factors are associated with diagnostic delays, the overall referral trajectory remains unclear. This study aimed to illustrate the diagnostic journey with a novel visual approach, the "referral odyssey plot," and to depict patient pathways and identify factors associated with referral delays and diagnosis. METHODS: We retrospectively reviewed 50 patients diagnosed with documented FDS at Tohoku University Hospital (2014-2024). All patients underwent comprehensive inpatient evaluation, including long-term video-electroencephalogram monitoring, brain MRI, and psychosocial assessment. Four milestones were defined: seizure onset (T1), first non-epileptologist visit (T2), first epileptologist consultation (T3), and epilepsy monitoring unit admission (T4). Diagnostic pathways were visualized using a referral odyssey plot. Associations between variables and intervals were analyzed using Spearman's correlation, Friedman test, Mann-Whitney U test, and Kruskal-Wallis test. RESULTS: The median total delay (T1-T4) was 51 months (interquartile range: IQR, 83.8). The longest delay occurred between T2 and T3 (median, 41 months; IQR, 74.8) and strongly correlated with total delay (ρ=0.95, p < 0.001). Younger age at onset and a family history of epilepsy were significantly associated with longer T2-T3 intervals. Seizure worry scores were negatively correlated with T1-T2 intervals. CONCLUSION: Referral delay to an epileptologist was the main contributor to prolonged diagnosis of FDS. The referral odyssey plot visualized individual trajectories and bottlenecks, supporting earlier specialist referrals. These findings highlight the need for timely access to epileptologists experienced in the comprehensive evaluation of epilepsy and FDS.

  4. Postsurgical psychogenic non-epileptic seizure: a treatment-related functional neurological disorder. International-journal Peer-reviewed

    Shin-Ichiro Osawa, Maimi Ogawa, Hirotaka Iwaki, Yuko Akitsuki, Mayu Fujikawa, Kazushi Ukishiro, Kazutaka Jin, Atsushi Sakuma, Hiroaki Tomita, Kyoko Suzuki, Nobukazu Nakasato, Hidenori Endo

    Journal of neurology, neurosurgery, and psychiatry　96　(12)　1233-1234　2025/11/13

    DOI： 10.1136/jnnp-2025-336913 　

  5. Impact of aphasia on verbal memory: insights from the Selective Anesthesia for Functional Evaluation. International-journal Peer-reviewed

    Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Journal of neurosurgery　143　(5)　1194-1201　2025/11/01

    DOI： 10.3171/2025.2.JNS242534 　

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    OBJECTIVE: The Wada test, an intracarotid amobarbital procedure, is the gold standard for the preoperative evaluation of postoperative memory decline in patients with drug-resistant epilepsy. However, because the anesthetic perfuses the language areas, infusion into the language-dominant hemisphere also causes aphasia. Although it has been noted that aphasia may affect verbal memory scores in the Wada test, the extent of the effects has not been verified. This study aimed to examine the extent to which verbal memory is affected by aphasia induced by selective anesthetization of the proximal middle cerebral artery (M1) area (which does not affect the hippocampus) in patients with drug-resistant epilepsy. METHODS: This single-center retrospective analysis included patients with drug-resistant epilepsy who underwent the Selective Anesthesia for Functional Evaluation (SAFE) as a preoperative evaluation between May 2018 and December 2023. SAFE includes cognitive tasks of equal difficulty administered before and immediately after anesthetic infusion. The preinfusion assessments confirmed the baseline, whereas the postinfusion assessments evaluated brain function under selective anesthesia. The patients were required to memorize 8 words and 8 pictures. After the anesthetic effects subsided, recognition tasks were performed for both words and pictures. The number of words and pictures successfully recognized were counted as verbal and visual memory scores, respectively. Memory scores were compared between the left and right M1 infusions. RESULTS: Of the 180 SAFE trials conducted during the study period, 38 trials (25 left and 13 right M1 infusions) in 29 patients with confirmed left language dominance and propofol infusion into the M1 were included. All left M1 infusions induced aphasia without causing significant disturbances in consciousness that could have interfered with task completion. The results indicated significantly lower verbal memory scores during left M1 infusions than during right M1 infusions, whereas the visual memory scores were comparable. CONCLUSIONS: The verbal memory score was significantly lower after infusion into the M1 of the language-dominant hemisphere than into the nondominant hemisphere, suggesting that aphasia during stimulus encoding may impair verbal memory. Thus, the Wada test with intracarotid anesthetic infusion may not accurately assess memory function due to aphasia. This study highlights the utility of SAFE in reducing aphasic interference in verbal memory, leading to a more accurate evaluation of surgical candidacy in patients with epilepsy.

  6. Unknown etiology group of late onset epilepsy more likely to show epileptiform EEG abnormalities than cerebrovascular disease group. International-journal Peer-reviewed

    Akihiko Nakaya, Kazuhiro Kato, Kazutaka Jin, Satoru Ohtomo, Nobukazu Nakasato, Masashi Aoki

    Epilepsy & behavior : E&B　172　110721-110721　2025/11

    DOI： 10.1016/j.yebeh.2025.110721 　

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    OBJECTIVE: To determine whether the cerebrovascular disease (CVD) group of late-onset epilepsy shows lower detection rates of interictal and ictal epileptiform abnormalities (EAs) using routine EEG than other etiology groups. METHODS: We retrospectively reviewed consecutive patients who had first seizure at age 65 years or older. The detection of EAs was investigated as well as background factors including age at EEG, timing of EEG after the last seizure, recording time of EEG, EEG-vigilance, and antiseizure medications. Multivariable logistic regression analysis was used to compare the detection rate of EAs between etiologies. RESULTS: EAs were detected in 53 (27 %) of 196 patients with late-onset epilepsy: 17 (20.7 %) of 82 patients with CVD, 9 (29.0 %) of 31 with traumatic brain injury, 4 (23.5 %) of 17 with other structural etiologies, 1 (20.0 %) of 5 with metabolic etiology, 9 (28.1 %) of 32 with dementia, and 13 (44.8 %) of 29 with unknown etiology. The odds ratios for EA detection, using the CVD group as the reference, were 1.60 for traumatic brain injury, 1.32 for other structural etiologies, 0.98 for metabolic etiology, 1.57 for dementia, and 4.10 for unknown etiology. The unknown etiology group showed significantly higher detection rate than the CVD group (p = 0.010). CONCLUSION: The higher detection rate in the unknown etiology group may indicate the presence of latent etiologies with high epileptic activity, while the lower detection rate in the CVD group may reflect electrophysiologically inactive lesions.

  7. Differentiation between epileptic and functional/dissociative seizures using density spectral array of ictal single-channel EEG with deep learning. International-journal Peer-reviewed

    Kazutoshi Konomatsu, Yuki Kashiwada, Takafumi Kubota, Kazutaka Jin, Ryu Koda, Kento Takahashi, Temma Soga, Makoto Ishida, Naoto Kuroda, Kazushi Ukishiro, Yosuke Kakisaka, Masashi Aoki, Nobukazu Nakasato

    Epilepsy & behavior : E&B　172　110713-110713　2025/11

    DOI： 10.1016/j.yebeh.2025.110713 　

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    Differentiating epileptic from non-epileptic seizures is the first step in the diagnosis of epilepsy. We investigated whether the density spectral array (DSA) of ictal EEG could differentiate between these seizures using a deep learning technique. We retrospectively reviewed consecutive patients with mesial temporal lobe epilepsy (mTLE) and functional/dissociative seizures (FDS) and analyzed seizures recorded using long-term video-EEG monitoring. The time of clinical onset was defined as zero, and the EEG recordings were clipped from -3 to + 3 min. Frequency analyses of Cz as well as means of C3 and C4, Fp1 and Fp2, O1 and O2, and all electrodes were performed to generate DSA with a linked-ear reference. ResNet34, which is a convolutional neural network (CNN) model, was trained and tested on these datasets. This study included 48 patients with mTLE and 51 with FDS. The CNN architecture was created using 40 patients with mTLE (91 seizures) and 40 with FDS (82 seizures) as training data, while eight patients with mTLE (15 seizures) and 11 with FDS (18 seizures) were evaluated using the model as test data. Exploratory analyses revealed that the Cz electrode and the Middle 1/3 interval yielded the highest area under the curve among the reduced-electrode settings (0.941), which was statistically confirmed by pre-specified DeLong tests after Bonferroni correction. The DSA of a single-channel EEG (Cz) successfully differentiated between epileptic and non-epileptic seizures using deep learning. These results highlight the potential of this approach as a practical adjunct to early screening and triage, particularly in resource-limited settings.

  8. Understanding enacted and felt stigma in temporal lobe epilepsy. International-journal Peer-reviewed

    Maimi Ogawa, Mayu Fujikawa, Katsuya Tasaki, Yosuke Kakisaka, Kazutaka Jin, Nobukazu Nakasato

    Epilepsy & behavior : E&B　171　110620-110620　2025/10

    DOI： 10.1016/j.yebeh.2025.110620 　

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    BACKGROUND: Self-stigma in epilepsy is conceptualized as enacted and felt stigma. Individuals with temporal lobe epilepsy (TLE) often face challenges that affect their self-perception and social engagement. This study explored the factors contributing to enacted and felt stigma among patients with TLE, considering both objective and subjective cognitive functions alongside biopsychosocial factors as explanatory variables. METHODS: The analysis included a total of 249 patients: 169 with TLE (90 females, 18-75 years) and with temporal lobe epilepsy (TLE) and 80 with other types of epilepsy (40 females, 18-71 years). Participants underwent video-electroencephalogram, neuroimaging, and neuropsychological and psychiatric evaluations. Information was derived from clinical records and validated psychosocial measures. The dataset was evaluated using a multivariate regression approach. RESULTS: In the TLE group, enacted and felt stigma were significantly increased by the female sex, longer duration of epilepsy, higher seizure worry, and lower social functioning. Additionally, enacted stigma was significantly enhanced by higher verbal intelligence quotient (IQ; p < 0.01), higher depression (p < 0.05), and poor social support (p < 0.05). The predictors explained 40 % and 37 % of the variance in enacted and felt stigma, respectively (both p < 0.01). CONCLUSION: Verbal IQ played a role in enacted stigma, whereas seizure-related worry was closely linked to felt stigma among patients with TLE.

  9. てんかん診療における心理職の役割 てんかん患者に対するテキストベース遠隔心理支援の可能性

    小川 舞美, 浮城 一司, 藤川 真由, 亀井 幹子, 小木曽 由佳, 古村 智, 遠藤 英徳, 中里 信和, 神 一敬

    てんかん研究　43　(2)　308-309　2025/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  10. 深層学習を用いた単チャネル脳波記録による全般起始発作と心因性非てんかん発作の鑑別

    幸田 龍, 此松 和俊, 柏田 祐樹, 久保田 隆文, 高橋 健斗, 黒田 直生人, 浮城 一司, 柿坂 庸介, 中里 信和, 青木 正志, 神 一敬

    てんかん研究　43　(2)　507-507　2025/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  11. 在宅長時間脳波記録を目的としたヘルメット型脳波計の実証研究

    浮城 一司, 佐藤 美輝, 石田 誠, 飯島 圭哉, 林 貴啓, 石川 英治, 渋谷 綱士, 中村 健太郎, 平塚 匡, 八木澤 隆, 山中 健介, 北添 雄眞, 岩崎 真樹, 神 一敬

    てんかん研究　43　(2)　508-508　2025/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  12. 【神経・精神科領域におけるデジタルメディスン】てんかん発作予測技術の現状と展望

    浮城 一司, 神 一敬, 中里 信和

    BRAIN and NERVE: 神経研究の進歩　77　(9)　0965-0968　2025/09

    Publisher: (株)医学書院

    ISSN： 1881-6096

    eISSN： 1344-8129

  13. Corrigendum to "Predictive value of the polygenic risk score for developing epilepsy: a systematic review and meta-analysis" [Epilepsy Behav. 169 (2025) 110438]. International-journal

    Takafumi Kubota, Irma Wati Ngadimon, Hisashi Ohseto, Sindhu Viswanathan, Parthvi Ravat, Mrinal Kumar Acharya, Naoto Kuroda, Kazutoshi Konomatsu, Taku Obara, Kazutaka Jin, Masashi Aoki, Nobukazu Nakasato

    Epilepsy & behavior : E&B　170　110513-110513　2025/09

    DOI： 10.1016/j.yebeh.2025.110513 　

  14. Retrospective interviews reveal unawareness of weakness following reversible hemispheric suppression: An exploratory study using selective anesthesia for functional evaluation. International-journal Peer-reviewed

    Hiroaki Hosokawa, Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Marie Oyafuso, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Kuniyasu Niizuma, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Cortex; a journal devoted to the study of the nervous system and behavior　190　146-154　2025/09

    DOI： 10.1016/j.cortex.2025.06.015 　

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    Unawareness of weakness-defined as an explicit failure to recognize one's own limb paresis after brain damage-has long been considered predominantly linked to right-hemisphere dysfunction, yet its laterality remains controversial. We retrospectively analyzed 86 sessions of Selective Anesthesia for Functional Evaluation (SAFE) conducted in 53 patients with surgical epilepsy. SAFE involves delivering a short-acting anesthetic into a single cortical artery branch, resulting in reversible cortical suppression. Contralateral weakness was defined as a positive Barré sign in the upper limb, corresponding to a Manual Muscle Test score of <3. Following the anesthetic effect, patients were asked whether they had experienced any motor impairment. Explicit unawareness was probed using two standardized questions, followed by a limb-specific inquiry. Interviews were conducted in real-time during 28 infusions and repeated within 30 sec of motor recovery in the remaining 58 sessions. Unawareness occurred in 41 of 52 left-hemisphere infusions (78.8%) and in 26 of 34 right-hemisphere infusions (76.5%). Real-time and immediate post hoc ratings were concordant in 26 of 28 paired assessments (93%). Infusions into the M2-superior division were associated with higher rates of unawareness than those into the M2-inferior division (odds ratio = 2.3, 95% confidence interval: 1.1-5.1). Within this reversible perfusion-suppression model, the frequency of unawareness of weakness was hemispherically balanced, promoting a cautious re-evaluation of the presumed right-hemisphere dominance. SAFE provides a practical tool for isolating transient awareness deficits without structural injury and may help bridge pharmacological and lesion-based approaches to brain-behavior mapping.

  15. [Current Status and Future Prospects of Seizure-Forecasting Technologies]. Invited

    Kazushi Ukishiro, Kazutaka Jin, Nobukazu Nakasato

    Brain and nerve = Shinkei kenkyu no shinpo　77　(9)　965-968　2025/09

    DOI： 10.11477/mf.188160960770090965 　

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    Epilepsy is a chronic neurological disorder that significantly impairs quality of life. Importantly, interest in seizure forecasting technologies has been growing in recent years. With the widespread adoption of noninvasive wearable devices, research has advanced in analyzing biological, behavioral, and environmental data using artificial intelligence to estimate individualized seizure risk. At Tohoku University, industry-academia collaborations have promoted the development and social implementation of machine-learning-based prediction models. This article provides an overview of the status and challenges of these efforts.

  16. Predictive value of the polygenic risk score for developing epilepsy: a systematic review and meta-analysis. International-journal Peer-reviewed

    Takafumi Kubota, Irma Wati Ngadimon, Hisashi Ohseto, Sindhu Viswanathan, Parthvi Ravat, Mrinal Kumar Acharya, Naoto Kuroda, Kazutoshi Konomatsu, Taku Obara, Kazutaka Jin, Masashi Aoki, Nobukazu Nakasato

    Epilepsy & behavior : E&B　169　110438-110438　2025/08

    DOI： 10.1016/j.yebeh.2025.110438 　

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    PURPOSE: This study aimed to integrate the findings of previous studies to clarify the predictive value of the polygenic risk score (PRS) for epilepsy. METHODS: The MEDLINE, EMBASE, and CENTRAL databases were systematically searched for studies investigating PRS in epilepsy. Additionally, a meta-analysis was performed using random-effects models of studies that included PRS calculations using similar methodologies. The main outcome was the odds ratio (OR) for developing epilepsy based on the generalized or focal epilepsy PRS. The risk of bias (Q-Genie tool) and heterogeneity between the studies were also assessed. RESULTS: Overall, 585 records were retrieved on April 27, 2024. Eleven studies were included in this systematic review. Most studies were conducted on cohorts with European ancestry. The risk of developing epilepsy increased with a higher PRS, which was more pronounced in patients with generalized epilepsy. The total Q-Genie tool score of the included studies was 50.9 (good quality: >45). The meta-analysis included two studies and found that the ORs for generalized epilepsy were 2.18 (95 % confidence interval [CI] 1.91-2.48), 2.65 (95 % CI 2.07-3.39), and 4.62 (95 % CI 3.45-6.20) for the top 20 %, 5 %, and 0.5 % of the PRS distribution, respectively; the respective ORs for focal epilepsy were 1.19 (95 % CI 0.84-1.67), 1.40 (95 % CI 1.28-1.52), and 1.69 (95 % CI 1.27-2.24). Significant heterogeneity was found only in the top 20 % of PRS cases for focal epilepsy (I2 = 97.0 %; Q test p < 0.0001). CONCLUSION: The PRS could be an effective tool for predicting development of epilepsy.

  17. Neuromagnetic evidence of the foot primary somatosensory area in the frontal cortex. International-journal Peer-reviewed

    Makoto Ishida, Haruka Katayama, Yosuke Kakisaka, Kazutaka Jin, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　176　2110767-2110767　2025/08

    DOI： 10.1016/j.clinph.2025.2110767 　

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    OBJECTIVE: The location of the foot primary somatosensory area (SI) is puzzling in contrast to the parietal localization of the hand SI. Electrical cortical stimulation studies have revealed the foot somatosensory function in the paracentral lobule anterior and posterior to the central sulcus (CS). A recent study of intraoperative somatosensory evoked potentials (SEPs) using posterior tibial nerve (PTN) stimulation revealed frontal localization of the foot SI. However, most previous studies using scalp SEPs and somatosensory evoked magnetic fields (SEFs) for PTN found that the initial cortical components (P40/P40m) were localized in the parietal lobe. This study evaluated the location of the equivalent current dipole (ECD) for PTN-SEFs on individual magnetic resonance imaging (MRI) in normal adults. METHODS: PTN-SEFs were recorded in 16 hemispheres of 8 normal subjects. The P40m ECD was superimposed on individual anatomical MRIs. RESULT: Mean ECD location of the P40m was 3.1 ± 4.2 mm (mean ± standard error) anterior and 6.9 ± 4.2 mm inferior to the inferior end of the CS. CONCLUSIONS: Our findings suggest frontal localization of the human foot SI. SIGNIFICANCE: The functional anatomy of the human foot SI cannot be established by extrapolation of the hand SI.

  18. Adult‐onset epilepsy with startle‐induced seizure after febrile infection‐related epilepsy syndrome: A case report Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Yu Fujiwara, Takafumi Kubota, Maimi Ogawa, Makoto Ishida, Kazushi Ukishiro, Hirohiko Ono, Kimihiko Kaneko, Naoto Sugeno, Masashi Aoki, Nobukazu Nakasato

    Epileptic Disorders　2025/04/15

    Publisher: Wiley

    DOI： 10.1002/epd2.70026 　

    ISSN： 1294-9361

    eISSN： 1950-6945

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    Abstract Startle‐induced seizure is a rare type of reflex seizure triggered by unexpected sensory stimuli that often occurs in children with early acquired cerebral lesions or brain malformations. We report a unique case of adult‐onset epilepsy with startle‐induced seizures. A 24‐year‐old woman had suffered high fever and focal to bilateral tonic–clonic seizures. A diagnosis of febrile infection‐related epilepsy syndrome (FIRES) was made based on the febrile infection occurring 7 days to 24 h before the onset of status epilepticus, which met all criteria for cryptogenic new‐onset refractory status epilepticus (NORSE) according to the cryptogenic NORSE score. Immunotherapy and several antiseizure medications resulted in transient resolution of the seizures. Four months later, she experienced startle‐induced seizures triggered by unexpected stimuli, such as auditory, visual, or unexpected events, and manifesting as initial tachycardia followed by right ear deafness, right hemifacial dysesthesia, eye deviation to the right, and tonic–clonic convulsions. Ictal electroencephalography revealed left temporal initial rhythmic delta activity, followed by rhythmic theta activity. The patient was diagnosed with startle epilepsy associated with FIRES and continued to receive anti‐seizure medications. Claustrum‐insular‐operculum lesions may have been the epileptic focus in this case, in contrast to previous cases of epilepsy with startle‐induced seizures originating in a frontoparietal network. This case indicates a new category of adult‐onset post‐FIRES epilepsy with startle‐induced seizures.

  19. Perforating artery injury as a critical factor besides cortical dysfunction in motor deficit after peri-rolandic epilepsy surgery. International-journal Peer-reviewed

    Atsuhiko Ninomiya, Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Kazushi Ukishiro, Yoshiteru Shimoda, Kazutaka Jin, Mitsugu Uematsu, Shiho Sato, Shunji Mugikura, Hiroyoshi Suzuki, Hajime Miyata, Shingo Kayano, Nobukazu Nakasato, Hidenori Endo

    Journal of neurosurgery　1-13　2025/02/14

    DOI： 10.3171/2024.10.JNS24878 　

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    OBJECTIVE: Surgery for peri-rolandic epilepsy requires appropriate consideration to balance the functional risk of postoperative motor deficit and seizure outcome. Based on voxel-based morphometric analysis, the authors hypothesized that cortical damage and ischemic subcortical damage related to surgery could affect postoperative motor deterioration. METHODS: Sixteen patients with peri-rolandic epilepsy who underwent resective surgery at a single institution were retrospectively investigated. Their imaging findings, postoperative seizure outcomes, and postoperative neurological deteriorations in motor function, as well as duration, were analyzed. Using the standardized MRI data of each case, the authors examined the surgically resected area on high-resolution 3D MR images and the high-intensity area on diffusion-weighted images, which were converted to voxel data. These voxel data were superimposed on a standard brain image for neuroimaging assessment. Postoperative motor deterioration of the orofacial region, upper limb, or lower limb was noted as no, transient, or permanent deterioration and analyzed in relation to the surgically resected area and subcortical damage. Univariate analysis of the clinical factors was conducted between cases with permanent upper- and/or lower-limb motor deterioration and those with no or transient deterioration. RESULTS: The mean follow-up period was 28 months. Ten patients (62.5%) achieved Engel class I. Fourteen patients (87.5%) experienced postoperative motor deteriorations in the following areas (no/transient/permanent): orofacial (11/5/0), upper limb (9/5/2), and lower limb (9/3/4). All cases with orofacial motor deterioration underwent cortical resection of the inferior third of the peri-rolandic cortex. Cortical resection of the precentral gyrus only, in contrast to both the precentral and postcentral gyri, was not associated with permanent upper- and/or lower-limb motor deterioration. Cortical resection involving the postcentral gyrus was significantly associated with permanent upper- and/or lower-limb motor deterioration in 4 cases (25.0%). Surgically related perforating artery injury caused ischemic subcortical damage, which was significantly associated with postoperative transient or permanent motor deterioration by extending to the corticospinal tract (CST). CONCLUSIONS: Postoperative motor deterioration for peri-rolandic epilepsy was related to both the resected cortex and ischemic subcortical damage. In peri-rolandic epilepsy, cortical resection of the precentral gyrus might not necessarily cause permanent upper- and/or lower-limb motor deterioration because of the functional reserve in other peri-rolandic areas outside the epileptic focus. On the other hand, cortical resection of the postcentral gyrus could cause permanent upper- and/or lower-limb motor deterioration because of injury to the vasculature, which is crucial for the descending motor pathway in the CST.

  20. Verbal Memory Localized in Non-language-dominant Hemisphere: Atypical Lateralization Revealed by Material-specific Memory Evaluation Using Super-selective Wada Test. Peer-reviewed

    Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    NMC case report journal　12　65-71　2025

    DOI： 10.2176/jns-nmc.2024-0217 　

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    Hippocampectomy is effective for drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis. However, multiple studies have reported high risks associated with hippocampectomy in patients with mesial temporal lobe epilepsy without hippocampal sclerosis on magnetic resonance imaging and in those with preserved memory function. Verbal memory and language functions are believed to coexist in the same hemisphere. We present a case of left mesial temporal lobe epilepsy with atypical memory function lateralization revealed by super-selective infusion of propofol to the intracranial artery (super-selective Wada test). A 24-year-old right-handed man with drug-resistant focal impaired awareness seizures was diagnosed with left mesial temporal lobe epilepsy without hippocampal sclerosis, but he showed preserved verbal intelligence quotient and memory, suggesting a high risk of severe memory decline after hippocampectomy. We performed super-selective Wada test to the posterior cerebral artery to assess the lateralization of verbal and visual memory separately, and to the middle cerebral artery to assess language function. The results revealed right-sided dominance for both verbal and visual memory, although the language was left-dominant. Hippocampectomy was performed and resulted in freedom from seizures. Memory assessments 1 year postoperatively showed no decline in all subtests. In patients with drug-resistant epilepsy exhibiting atypical neuropsychological profiles, the memory-dominant, and language-dominant hemispheres may not align; detailed evaluations of function lateralization are necessary for tailored treatment.

  21. Perceptions in the experience of transition from pediatric to adult care of patients with childhood-onset epilepsy in Japan Peer-reviewed

    Takumi Sasaki, Wataru Irie, Akiko Sugahara, Kazutaka Jin, Nobukazu Nakasato, Hitoshi Shiwaku

    Epilepsy &amp; Behavior　161　110119-110119　2024/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.yebeh.2024.110119 　

    ISSN： 1525-5050

  22. Recurring utterances induced by local anesthetic administration to the left frontal lobe. International-journal Peer-reviewed

    Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Makoto Ishida, Kazushi Ukishiro, Kazutaka Jin, Shingo Kayano, Shunji Mugikura, Hidenori Endo, Nobukazu Nakasato, Minoru Matsuda, Kyoko Suzuki

    Cortex; a journal devoted to the study of the nervous system and behavior　183　15-20　2024/11/19

    DOI： 10.1016/j.cortex.2024.10.019 　

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    Recurring utterances (RUs) are a distinct language symptom observed in severe aphasia, known to be associated with global or Broca's aphasia, though their neural basis remains unclear. We present a case of RU induced by selective left frontal suppression using a novel technique named the super-selective Wada test (ssWada), which involves temporary anesthetization of specific brain regions through super-selective catheterization of cerebral arteries. This method allows for precise simulation of localized brain dysfunction. We applied this technique on a 49-year-old right-handed man with drug-resistant epilepsy as a preoperative examination. Propofol administration to the superior branch of the left middle cerebral artery (MCA), supplying the pars triangularis, pars opercularis, middle frontal gyrus, and part of the precentral gyrus, induced Broca's aphasia with RUs. The RU content was the phrase uttered at anesthesia administration. Notably, the anesthetic did not affect the temporal language area or basal ganglia. The patient showed minimal awareness of his abnormal speech despite preserved receptive language function and memory, aligning with previous observations of anosognosia in patients with RU. Contrastingly, anesthetic infusion into the inferior branch of the left MCA resulted in mixed aphasia, while right MCA infusion induced no language impairments. This case demonstrates that RUs can arise without deficits in the posterior language area or basal ganglia. It illustrates the potential of ssWada in investigating neural substrates of neuropsychological symptoms through temporary, localized brain disruption. This approach offers novel insights into brain-behavior relationships in language processing and cognition.

  23. Individual and relational factors related to disclosure of epilepsy in the workplace Peer-reviewed

    Maimi Ogawa, Mayu Fujikawa, Katsuya Tasaki, Kazushi Ukishiro, Yosuke Kakisaka, Kazutaka Jin, Nobukazu Nakasato

    Epilepsy &amp; Behavior　160　110079-110079　2024/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.yebeh.2024.110079 　

    ISSN： 1525-5050

  24. 焦点および全般てんかんではどの睡眠段階で発作間欠時てんかん放電がみられるか?

    板橋 泉, 浅黄 優, 神 一敬, 浮城 一司, 三木 俊, 中里 信和

    臨床神経生理学　52　(5)　571-571　2024/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  25. 体性感覚誘発磁界による下肢一次体性感覚野の前頭葉局在の検証

    石田 誠, 片山 遥, 神 一敬, 柿坂 庸介, 中里 信和

    臨床神経生理学　52　(5)　590-590　2024/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  26. 左側頭葉新皮質病変を伴うてんかんにおける発作時心拍上昇率の比較

    高野 歩有, 浮城 一司, 曽我 天馬, 神 一敬, 板橋 泉, 大沢 伸一郎, 岩崎 真樹, 遠藤 英徳, 中里 信和

    臨床神経生理学　52　(5)　622-622　2024/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  27. Complete Corpus Callosotomy Brings Worthwhile Seizure Reduction in Both Pediatric and Adult Patients. International-journal Peer-reviewed

    Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

    Neurosurgery　2024/07/02

    DOI： 10.1227/neu.0000000000003092 　

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    BACKGROUND AND OBJECTIVES: The influence of the age at which complete corpus callosotomy (CC) surgery is performed on seizure outcomes remains unclear. This study aimed to evaluate the age-dependent aspects of long-term seizure outcomes after complete CC. METHODS: We reviewed 41 patients who underwent one-stage complete CC. Seizure outcomes were analyzed for age at epilepsy onset and at complete CC, focal MRI abnormality, and etiology. RESULTS: The median age was 7 months at epilepsy onset and 93 months at complete CC. The median follow-up duration was 67 months. Sixteen patients had focal MRI lesions and 4 had only general atrophy. Etiology was identified in 20 patients. For overall seizure outcomes (N = 41), complete seizure freedom was achieved in 5 patients, excellent seizure reduction (>80%) in 11, good (50%-80%) in 5, and poor (<50%) in 20. Freedom was correlated with younger age at complete CC and unknown etiology (P ≤ .05). Freedom was only achieved in patients aged younger than 7 years. Worthwhile (≥50%, freedom, excellent, and good) and not worthwhile (<50%, poor) overall seizure reduction showed no statistical difference in age at complete CC. No related factor was found for worthwhile overall seizure reduction. For drop attack outcomes (N = 31), freedom was achieved in 22 cases, excellent in 5, and poor in 4. Freedom was correlated with younger age at complete CC (P < .05) although freedom was achieved in 4 of 7 patients older than 20 years. Age at complete CC showed no statistical difference between worthwhile (≥50%) and not worthwhile (<50%) drop attack reduction. Worthwhile drop attack reduction was correlated with unknown etiology (P < .05). Complications were mild and transient. CONCLUSION: Complete CC is an excellent surgical option based on favorable seizure outcomes and acceptable complications in our present study.

  28. Somatosensory evoked spikes in normal adults detected by magnetoencephalography. International-journal Peer-reviewed

    Makoto Ishida, Yosuke Kakisaka, Kazutaka Jin, Akitake Kanno, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　164　19-23　2024/05/22

    DOI： 10.1016/j.clinph.2024.05.006 　

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    OBJECTIVE: Somatosensory evoked spikes (SESs) have been reported only in children aged under 14 years and are considered as an age-dependent phenomenon. However, we detected SESs in adult patients with epilepsy using magnetoencephalography (MEG). The present study investigated whether MEG can detect SESs in normal adults. METHODS: Spontaneous MEG was recorded during measurement of somatosensory evoked fields (SEFs) for bilateral electrical median nerve stimuli in 30 healthy adults. RESULTS: Bilateral SESs were observed in 10 adults but none in the other 20 subjects. SESs consisted of one or two peaks, and the first peak latency corresponded to that of the second peak (M2) of SEFs. The first SES peak was identical to the M2 in isofield map pattern, as well as location and orientation of the equivalent current dipole (ECD). M2 ECD strength in the 10 subjects with SESs was larger (p <0.0001) than in 20 without SESs. CONCLUSIONS: All-or-nothing detection of bilateral SESs by MEG in normal adults must depend on the signal-to-noise issue of symmetrical SEFs and background brain activity. SIGNIFICANCE: Our results further confirm the higher sensitivity of MEG compared to scalp EEG for the detection of focal cortical sources tangential to the scalp such as SESs.

  29. Super-selective injection of propofol into the intracranial arteries enables Patient's self-evaluation of expected neurological deficit. International-journal Peer-reviewed

    Shin-Ichiro Osawa, Kyoko Suzuki, Kazushi Ukishiro, Kazuo Kakinuma, Makoto Ishida, Kuniyasu Niizuma, Yoshiteru Shimoda, Hana Kikuchi, Ryuzaburo Kochi, Kazutaka Jin, Yasushi Matsumoto, Mitsugu Uematsu, Nobukazu Nakasato, Hidenori Endo, Teiji Tominaga

    Cortex; a journal devoted to the study of the nervous system and behavior　176　209-220　2024/05/19

    DOI： 10.1016/j.cortex.2024.04.016 　

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    INTRODUCTION: It is hard to realize the extent of the expected postoperative neurological deficit for patients themselves. The provision of appropriate information can contribute not only to examining surgical indications but also to filling the gap between patient and expert expectations. We hypothesized that propofol infusion into the intracranial arteries (ssWada) could induce focal neurological symptoms with preserved wakefulness, enabling the patients to evaluate the postsurgical risk subjectively. METHODS: Presurgical evaluation using ssWada was performed in 28 patients with drug-resistant epilepsy. Based on anatomical knowledge, propofol was super-selectively infused into the intracranial arteries including the M1, M2, and M3 segments of the middle cerebral artery (MCA), A2 segment of the anterior cerebral artery, and P2 segment of the posterior cerebral artery to evaluate the neurological and cognitive symptoms. We retrospectively analyzed a total of 107 infusion trials, including their target vessels, and elicited symptoms of motor weakness, sensory disturbance, language, unilateral hemispatial neglect (UHN), and hemianopsia. We evaluated preserved wakefulness which enabled subjective evaluations of the symptoms and comparison of the subjective experience to the objective findings, besides adverse effects during the procedure. RESULTS: Preserved wakefulness was found in 97.2% of all trials. Changes in neurological symptoms were positively evaluated for motor weakness in 51.4%, sensory disturbance in 5.6%, language in 48.6%, UHN in 22.4%, and hemianopsia in 32.7%. Six trials elicited seizures. Multivariate analysis showed significant correlations between symptom and infusion site of language and left side, language and MCA branches, motor weakness and A2 or M2 superior division, and hemianopsia and P2. Transient adverse effect was observed in 8 cases with 12 infusion trials (11.2 %). CONCLUSION: The ssWada could elicit focal neurological symptoms with preserved wakefulness. The methodology enables specific evaluation of risk for cortical resection and subjective evaluation of the expected outcome by the patients.

  30. Remission of startle epilepsy provoked by acoustic stimuli following complete callosotomy: A case study. International-journal Peer-reviewed

    Kazushi Ukishiro, Shin-Ichiro Osawa, Yosuke Kakisaka, Kazutaka Jin, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

    Epileptic disorders : international epilepsy journal with videotape　2024/05/07

    DOI： 10.1002/epd2.20238 　

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    Herein, we present the case of a 21-year-old man with a history of generalized tonic seizures since the age of 4 years. These seizures occurred either spontaneously or could be provoked by auditory stimuli such as the sounds of a vacuum cleaner or an electric shaver. Despite trials with 10 different anti-seizure medications, his seizures remained refractory. Interictal electroencephalography (EEG) revealed generalized epileptiform activity, whereas ictal EEG showed a generalized attenuation pattern. Magnetic resonance imaging revealed extensive chronic infarctions, predominantly in the bilateral cerebral watershed areas. At the age of 17, the patient underwent a one-stage complete callosotomy, which only achieved remission of auditory-provoked seizures. Based on this experience and published reports, we propose that the posterior corpus callosum, particularly the isthmus and anterior splenium, may be involved in seizures caused by unexpected sound stimuli.

  31. “Caterpillar sign” in corpus callosum associated with curvilinear pericallosal lipoma in MRI: A case report Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Shiho Sato, Takafumi Kubota, Temma Soga, Kazushi Ukishiro, Kazutaka Jin, Shunji Mugikura, Masashi Aoki, Nobukazu Nakasato

    Radiology Case Reports　19　(5)　2058-2061　2024/05

    DOI： 10.1016/j.radcr.2024.02.058 　

    eISSN： 1930-0433

  32. Genetic generalized epilepsy with catecholaminergic polymorphic ventricular tachycardia complicated by ryanodine receptor 2 variant: A case report Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Takeshi Aiba, Shin Takahashi, Hironobu Ueda, Takafumi Kubota, Temma Soga, Kazushi Ukishiro, Masashi Aoki, Nobukazu Nakasato

    Seizure: European Journal of Epilepsy　117　284-287　2024/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.seizure.2024.04.003 　

    ISSN： 1059-1311

  33. Assessment of language lateralization in epilepsy patients using the super-selective Wada test. International-journal Peer-reviewed

    Kazuo Kakinuma, Shin-Ichiro Osawa, Kazuto Katsuse, Hiroaki Hosokawa, Kazushi Ukishiro, Kazutaka Jin, Kuniyasu Niizuma, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Acta neurochirurgica　166　(1)　77-77　2024/02/10

    DOI： 10.1007/s00701-024-05957-8 　

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    BACKGROUND: The classical Wada test (cWada), performed by injecting a short-acting anesthetic through the intracarotid route, helps determine language dominance. In the cWada, adverse effects are observed in 10-30% of trials, hindering accurate assessments. In this study, we assessed the effectiveness of the super-selective Wada test (ssWada), a more selective approach for anesthetic infusion into the middle cerebral artery (MCA). METHODS: We retrospectively examined the data of 17 patients with epilepsy who underwent ssWada via anesthetic injection into one M1 segment of the MCA and at least one contralateral trial. RESULTS: The ssWada identified 12 patients with left language dominance, 3 with right language dominance, and 2 with bilateral language distribution. Nine trials on the language dominant side resulted in global aphasia for patients with left- or right language dominance. Of the 13 trials conducted on the non-dominant language side, 12 revealed intact language function and one resulted in confusion. Among these, the outcomes of global aphasia or no language impairment were confirmed in the contralateral trials. Among the 22 trials of unilateral M1 injections in patients with unilateral language dominance, 21 (95.5%) showed either global aphasia or no language impairment, indicating language dominance. CONCLUSIONS: The ssWada yields clear results, with a high rate of over 90% in determining the language dominant hemisphere with few side effects.

  34. Ongoing EEG artifact correction using blind source separation. International-journal Peer-reviewed

    Nicole Ille, Yoshiaki Nakao, Shumpei Yano, Toshiyuki Taura, Arndt Ebert, Harald Bornfleth, Suguru Asagi, Kanoko Kozawa, Izumi Itabashi, Takafumi Sato, Rie Sakuraba, Rie Tsuda, Yosuke Kakisaka, Kazutaka Jin, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　158　149-158　2024/01/04

    DOI： 10.1016/j.clinph.2023.12.133 　

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    OBJECTIVE: Analysis of the electroencephalogram (EEG) for epileptic spike and seizure detection or brain-computer interfaces can be severely hampered by the presence of artifacts. The aim of this study is to describe and evaluate a fast automatic algorithm for ongoing correction of artifacts in continuous EEG recordings, which can be applied offline and online. METHODS: The automatic algorithm for ongoing correction of artifacts is based on fast blind source separation. It uses a sliding window technique with overlapping epochs and features in the spatial, temporal and frequency domain to detect and correct ocular, cardiac, muscle and powerline artifacts. RESULTS: The approach was validated in an independent evaluation study on publicly available continuous EEG data with 2035 marked artifacts. Validation confirmed that 88% of the artifacts could be removed successfully (ocular: 81%, cardiac: 84%, muscle: 98%, powerline: 100%). It outperformed state-of-the-art algorithms both in terms of artifact reduction rates and computation time. CONCLUSIONS: Fast ongoing artifact correction successfully removed a good proportion of artifacts, while preserving most of the EEG signals. SIGNIFICANCE: The presented algorithm may be useful for ongoing correction of artifacts, e.g., in online systems for epileptic spike and seizure detection or brain-computer interfaces.

  35. 海馬硬化を伴う内側側頭葉てんかん患者における側頭葉深部の脳磁図棘波信号源の臨床的意義

    大村 花薫子, 石田 誠, 柿坂 庸介, 神 一敬, 大沢 伸一郎, 中里 信和

    日本生体磁気学会誌　37　(1)　140-141　2024

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  36. Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis Peer-reviewed

    Shunji Mugikura, Naoko Mori, Miyeong Gang, Shigenori Kanno, Kazutaka Jin, Shin-Ichiro Osawa, Nobukazu Nakasato, Kei Takase

    Journal of Clinical Imaging Science　13　38-38　2023/12/22

    Publisher: Scientific Scholar

    DOI： 10.25259/jcis_77_2023 　

    ISSN： 2156-7514

    eISSN： 2156-5597

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    Objectives: To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides. Material and Methods: Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox. Results: Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions. Conclusion: By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.

  37. Language MEG predicts postoperative verbal memory change in left mesial temporal lobe epilepsy Peer-reviewed

    Ryuzaburo Kochi, Shin-ichiro Osawa, Kazutaka Jin, Makoto Ishida, Akitake Kanno, Masaki Iwasaki, Kyoko Suzuki, Ryuta Kawashima, Teiji Tominaga, Nobukazu Nakasato

    Clinical Neurophysiology　2023/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.clinph.2023.09.010 　

    ISSN： 1388-2457

  38. Referral odyssey plot to visualize causes of surgical delay in mesial temporal lobe epilepsy with hippocampal sclerosis. International-journal Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Makoto Ishida, Temma Soga, Kazushi Ukishiro, Shin-Ichiro Osawa, Kazutaka Jin, Masashi Aoki, Nobukazu Nakasato

    Epilepsy & behavior : E&B　147　109434-109434　2023/09/14

    DOI： 10.1016/j.yebeh.2023.109434 　

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    The "odyssey plot" was used to visualize referral delays in epilepsy surgery. Participants were 36 patients (19 males; 13-67 years, median 27 years) with mesial temporal lobe epilepsy with hippocampal sclerosis (HS) who underwent resection surgery. The "referral odyssey plot" included five clinical episodes: seizure onset (T1), first visits to a non-epileptologist (T2) and to an epileptologist (T3), first admission to our epilepsy monitoring unit (EMU) (T4), and resection surgery (T5). For each patient, we identified the first seizure type: the physician who first diagnosed focal aware seizure (FAS), focal impaired awareness seizure (FIAS), focal to bilateral tonic-clonic seizure (FBTCS), and radiologically suspected HS. Within the overall delay (T1-T5, median 18 years; interquartile range [IQR] 14), non-epileptologist's delay (T2-T3, 11.5 years; IQR 12.25) was far (p < 0.0001) longer than patient's (T1-T2, 0 year; IQR 2.25), epileptologist's (T3-T4, 1 year; IQR 4), or after-EMU delay (T4-T5, 1 year; IQR 1). FAS onset cases had significantly longer T1-T2 (N = 5, median 7 years; IQR 6) than FIAS (N = 22, 0 year; IQR 1, p < 0.005) or FBTCS onset cases (N = 9, 0 year; IQR 0, p < 0.001). FAS was correctly diagnosed first by non-epileptologists in 17.9%, by out-patient epileptologists in 35.7%, and at the EMU in 46.4%. FIAS was correctly diagnosed first by non-epileptologists in 94.4% and by out-patient epileptologists in 5.6%. Non-epileptologists diagnosed FBTCS in all cases. HS was diagnosed by non-epileptologists in 13.9%, by out-patient epileptologists in 47.2%, and at the EMU in 38.9%. Early referral to epileptologists is most critical for early surgery. Early utilization of the EMU is highly recommended because FAS is often overlooked by outpatient epileptologists. The odyssey plot will be useful to improve the healthcare system for other types of epilepsy.

  39. Temporomandibular joint dislocation during epileptic seizures in the epilepsy monitoring unit: A case report Peer-reviewed

    Takafumi Kubota, Kazutaka Jin, Keigo Honoki, Temma Soga, Kazushi Ukishiro, Yosuke Kakisaka, Masashi Aoki, Nobukazu Nakasato

    Epileptic Disorders　2023/09

    Publisher: Wiley

    DOI： 10.1002/epd2.20158 　

    ISSN： 1294-9361

    eISSN： 1950-6945

  40. Dynamic electro‐clinical changes corresponding to immediate recovery after glucose administration from insulinoma‐induced hypoglycemia: report of two cases Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Kazushi Ukishiro, Ayumi Sakata, Takafumi Shimogawa, Takato Morioka, Takafumi Kubota, Temma Soga, Masashi Aoki, Nobukazu Nakasato

    Epileptic Disorders　2023/08/26

    Publisher: Wiley

    DOI： 10.1002/epd2.20155 　

    ISSN： 1294-9361

    eISSN： 1950-6945

  41. Causal involvement of medial inferior frontal gyrus of non-dominant hemisphere in higher order auditory perception: A single case study. International-journal Peer-reviewed

    Shin-Ichiro Osawa, Kyoko Suzuki, Eishi Asano, Kazushi Ukishiro, Dai Agari, Kazuo Kakinuma, Ryuzaburo Kochi, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    Cortex; a journal devoted to the study of the nervous system and behavior　163　57-65　2023/03/29

    DOI： 10.1016/j.cortex.2023.02.007 　

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    The medial side of the operculum is invisible from the lateral surface of cerebral cortex, and its functions remain largely unexplored using direct evidence. Non-invasive and invasive studies have proved functions on peri-sylvian area including the inferior frontal gyrus (IFG) and superior temporal gyrus within the language-dominant hemisphere for semantic processing during verbal communication. However, within the non-dominant hemisphere, there was less evidence of its functions except for pitch or prosody processing. Here we add direct evidence for the functions of the non-dominant hemisphere, the causal involvement of the medial IFG for subjective auditory perception, which is affected by the context of the condition, regarded as a contribution in higher order auditory perception. The phenomenon was clearly distinguished from absolute and invariant pitch perception which is regarded as lower order auditory perception. Electrical stimulation of the medial surface of pars triangularis of IFG in non-dominant hemisphere via depth electrode in an epilepsy patient rapidly and reproducibly elicited perception of pitch changes of auditory input. Pitches were perceived as either higher or lower than those given without stimulation and there was no selectivity for sound type. The patient perceived sounds as higher when she had greater control over the situation when her eyes were open and there were self-cues, and as lower when her eyes were closed and there were investigator-cues. Time-frequency analysis of electrocorticography signals during auditory naming demonstrated medial IFG activation, characterized by low-gamma band augmentation during her own vocal response. The overall evidence provides a neural substrate for altered perception of other vocal tones according to the condition context.

  42. Ictal chest discomfort in a patient with temporal lobe seizures and amygdala enlargement Peer-reviewed

    Hisashi Ohseto, Temma Soga, Yosuke Kakisaka, Kazutaka Jin, Kazushi Ukishiro, Kazutoshi Konomatsu, Takafumi Kubota, Juichi Fujimori, Nobukazu Nakasato

    Epilepsy &amp; Behavior Reports　100578-100578　2022/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.ebr.2022.100578 　

    ISSN： 2589-9864

  43. Determination of language areas in patients with epilepsy using the super-selective Wada test. International-journal Peer-reviewed

    Kazuo Kakinuma, Shin-Ichiro Osawa, Hiroaki Hosokawa, Marie Oyafuso, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Takafumi Sato, Mika Sakamoto, Kuniyasu Niizuma, Teiji Tominaga, Nobukazu Nakasato, Kyoko Suzuki

    IBRO neuroscience reports　13　156-163　2022/12

    DOI： 10.1016/j.ibneur.2022.08.002 　

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    The Wada test is the gold standard for determining language-dominant hemisphere. However, the precise determination of language areas in each patient requires more invasive methods, such as electrocortical stimulation. Some studies have reported the use of anesthetic injection into selective cerebral arteries to predict postoperative function. To assess the function of the anterior and posterior language areas separately, we developed an advanced test named the "super-selective Wada test" (ssWada). The ssWada procedure is as follows: an endovascular neurosurgeon identifies the arterial branches of the middle cerebral artery (MCA) perfusing the anterior language area of the inferior frontal gyrus and the posterior language area of the posterior part of the superior temporal gyrus using angiography. Behavioral neurologists assess language symptoms before and after propofol administration using a microcatheter tip in the selected arterial branch. From 30 serial patients with epilepsy who underwent ssWada test at Tohoku University Hospital, we retrospectively reviewed patients in whom multiple areas in the bilateral MCA region was examined. Eight cases were identified in this study. All eight cases had been considered for resection of the area overlapping the classical language area. Three of the eight cases were left-dominant, and the within-hemisphere distribution was also considered typical. One case was determined to be left-dominant but atypical in the intra-hemispheric functional distribution. Two cases were right-dominant, and the intra-hemispheric functional distribution was considered a mirror image of the typical pattern. The remaining two cases were considered atypical, not only in terms of bilateral language function, but also in terms of anterior-posterior functional distribution. This case series demonstrates the potential utility of ssWada in revealing separate function of the anterior and posterior language areas. The ssWada allows simulation of local surgical brain resection and detailed investigation of language function, which potentially contributes to planning the resection area. Although indications for ssWada are quite limited, it could play a complementary role to noninvasive testing because it provides information related to resection using a different approach.

  44. Development of an epileptic seizure prediction algorithm using R–R intervals with self-attentive autoencoder Peer-reviewed

    Rikumo Ode, Koichi Fujiwara, Miho Miyajima, Toshikata Yamakawa, Manabu Kano, Kazutaka Jin, Nobukazu Nakasato, Yasuko Sawai, Toru Hoshida, Masaki Iwasaki, Yoshiko Murata, Satsuki Watanabe, Yutaka Watanabe, Yoko Suzuki, Motoki Inaji, Naoto Kunii, Satoru Oshino, Hui Ming Khoo, Haruhiko Kishima, Taketoshi Maehara

    Artificial Life and Robotics　2022/11/27

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s10015-022-00832-0 　

    ISSN： 1433-5298

    eISSN： 1614-7456

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    Abstract Epilepsy is a neurological disorder that may affect the autonomic nervous system (ANS) from 15 to 20 min before seizure onset, and disturbances of ANS affect R–R intervals (RRI) on an electrocardiogram (ECG). This study aims to develop a machine learning algorithm for predicting focal epileptic seizures by monitoring R–R interval (RRI) data in real time. The developed algorithm adopts a self-attentive autoencoder (SA-AE), which is a neural network for time-series data. The results of applying the developed seizure prediction algorithm to clinical data demonstrated that it functioned well in most patients; however, false positives (FPs) occurred in specific participants. In a future work, we will investigate the causes of FPs and optimize the developing seizure prediction algorithm to further improve performance using newly added clinical data.

  45. Distribution of postictal slowing has an additional yield to interictal epileptiform discharge in predicting surgical outcomes in temporal lobe epilepsy. International-journal Peer-reviewed

    Sally Shaaban, Yosuke Kakisaka, Tamer Belal, Kazutaka Jin, Shin-Ichiro Osawa, Teiji Tominaga, Ibrahim Elmenshawi, Nobukazu Nakasato

    Epilepsia open　7　(4)　802-809　2022/10/12

    DOI： 10.1002/epi4.12660 　

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    OBJECTIVE: To investigate whether the slowing of bilateral postictal scalp electroencephalography (EEG) after focal impaired awareness seizures is associated with poor seizure outcomes after temporal lobe epilepsy (TLE) surgery. METHODS: This retrospective cohort study was conducted in the Department of Epileptology, Tohoku University Hospital from 2010 to 2020. The study included 42 patients with TLE who underwent a detailed presurgical evaluation and sequential resective surgery for the unilateral probable epileptogenic temporal lobe with one year or more of follow-up. We reviewed the interictal epileptiform distribution and those of the ictal and postictal epochs of the first focal impaired awareness seizure recorded in presurgical scalp EEG. We classified patients either with postoperative seizure-free status (Engel I) as group A or those with seizure persistence (Engel II-IV) as group B. RESULTS: Of 42 patients, 29 (69 %) were classified into group A. Compared with group B, group A had a lower number of bilateral postictal polymorphic delta activity (PPDA) (10.3%: 61.5%) and bilateral interictal epileptiform discharges (IEDs) (13.8%: 69.2%) (p=0.003, p=0.001, respectively). A combined analysis of bilateral PPDA and IEDs per individual patient showed significantly more frequent seizure persistence after surgery (p <0.0001) than a single analysis of bilateral IEDs or PPDA alone (p=0.001). The regression analysis revealed that bilaterally distributed PPDA or IEDs had 13.50 or 13.72 times higher odds of persisting seizures within 1 year of surgery (95% confidence interval: 1.90-95.88; 2.12-88.87, respectively) (p=0.009, 0.006). SIGNIFICANCE: The results of this study revealed that the bilateral distribution of PPDA was associated with poor postoperative seizure outcomes in patients with TLE, as well as bilateral IEDs. Additionally, the concomitant bilateral distribution of interictal and postictal changes is a strong indicator of poor surgical outcomes.

  46. Prescription trends in anti-seizure medications for adult patients with epilepsy in Japan: A retrospective cohort study using the database of health insurance claims between 2015 and 2019. International-journal Peer-reviewed

    Kazutaka Jin, Taku Obara, Kyoko Hirano, Daichi Hirai, Masatoshi Kiuchi, Takeshi Tanaka, Nobukazu Nakasato

    Epilepsy & behavior : E&B　134　108841-108841　2022/07/25

    DOI： 10.1016/j.yebeh.2022.108841 　

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    OBJECTIVE: To investigate whether newer anti-seizure medications (ASMs) are widely prescribed for a range of adult patients in Japan, including patients with previously and newly diagnosed epilepsy, or with focal and generalized epilepsies. METHODS: A retrospective cohort study was conducted using the Japanese insurance claims database including 8.4 million people to identify adults (≥16 years of age) with epilepsy diagnosis code identified between January 2015 and December 2018. Patients were included in the prevalent population if epilepsy was already diagnosed at baseline, and in the incident population if prior baseline data for at least 12 months included no epilepsy diagnosis code or ASM prescription. Patients were followed up from the month when the initial oral ASM was prescribed for up to 4 years until the end of 2019 as long as at least one ASM was prescribed. Proportions of prescribed oral ASMs were analyzed by population with epilepsy (prevalent vs. incident) and classification (focal vs. generalized). Anti-seizure medications were classified into older vs. newer ASMs according to the date of approval before and after 1990, respectively. RESULTS: A total of 24,691 patients fulfilled the eligibility criteria for the analysis. Of these, 21,046 and 3,645 were included in the prevalent and incident populations, respectively. The proportion of older ASMs significantly decreased, whereas the proportion of newer ASMs significantly increased (p < 0.0001) during the study period. This trend was more apparent in the population with incident epilepsy than in that with prevalent epilepsy, and was also apparent in the subgroup of focal epilepsy, but not in that of generalized epilepsy. Levetiracetam was the most frequently prescribed of the newer ASMs. CONCLUSION: Newer ASMs became more widely prescribed throughout the study period in populations with both prevalent and incident epilepsies, as well as the subpopulation with focal epilepsy. The advantages of newer ASMs such as better safety profiles may have led to the increasing proportions of prescriptions and newer ASMs may increase the treatment options for patients.

  47. Development and validation of the Japanese version of the Epilepsy Stigma Scale in adults with epilepsy. International-journal Peer-reviewed

    Maimi Ogawa, Mayu Fujikawa, Katsuya Tasaki, Kazutaka Jin, Yosuke Kakisaka, Nobukazu Nakasato

    Epilepsy & behavior : E&B　134　108832-108832　2022/07/18

    DOI： 10.1016/j.yebeh.2022.108832 　

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    BACKGROUND: Self-stigma is considered to have immensely negative influences on the living and psychological states in patients with epilepsy. Understanding the stigma experienced by patients with epilepsy is essential considering its negative impact on their treatment and quality of life (QOL). However, few sufficiently validated self-report instruments are available to evaluate self-stigma in patients with epilepsy. The Epilepsy Stigma Scale (ESS) is one of the most commonly used self-reported questionnaires available to evaluate self-stigma in patients with epilepsy. The present study translated the ESS into Japanese to validate the Japanese version of the ESS (ESS-J) in Japanese adults with epilepsy. METHODS: The study included 338 patients with epilepsy (166 men, aged 18-75 years) who underwent comprehensive assessment including long-term video-electroencephalography monitoring, neuroimaging studies, and neuropsychological and psychosocial assessments in the Tohoku University Hospital Epilepsy Monitoring Unit. This study consisted of two phases: (1) translation of the ESS into Japanese using the back-translation technique; and (2) statistical analysis of the ESS-J to evaluate the factor structure, reliability, and validity. RESULTS: The 2-factor model achieved acceptable fit to the data: χ2 = 161.27, df = 34, p < 0.01, comparative fit index = 0.929, root mean square error of approximation = 0.105, standardized root mean squared residual = 0.047, Akaike's information criterion = 203.27 and, Bayesian information criterion = 283.56. These two subscales were named enacted stigma and felt stigma based on the theoretical model of self-stigma. We found the ESS-J to have acceptable internal consistency as follows: enacted (7 items; α = 0.88) and felt stigma subscale (3 items; α = 0.82). The concurrent validity was confirmed by adequate correlation with other related instruments. Both enacted and felt stigma had positive and moderate correlations with depression as measured by the Neurological Disorders Depression Inventory for Epilepsy (r = 0.44, p < 0.01; r = 0.41, p < 0.01, respectively) and with anxiety as measured by the Generalized Anxiety Disorder -7 (r = 0.48, p < 0.01; r = 0.38, p < 0.01, respectively). CONCLUSION: The ESS-J demonstrated acceptable validity and reliability. The present study provided preliminary evidence about the psychometric properties of the ESS-J, indicating the reliable factorial structure, adequate internal consistency, and satisfactory construct and concurrent validity. Measurement of the two types of self-stigma may offer a useful tool for clinical interpretation of patients' psychological state throughout epilepsy care, and as one of the patient-reported outcomes in QOL research.

  48. Abnormal heart rate variability during non-REM sleep and postictal generalized EEG suppression in focal epilepsy. International-journal Peer-reviewed

    Mika Sakamoto, Kazutaka Jin, Yu Kitazawa, Yosuke Kakisaka, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　140　40-44　2022/05/27

    DOI： 10.1016/j.clinph.2022.05.011 　

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    OBJECTIVE: To identify any relationship between abnormal interictal heart rate variability (HRV) during sleep and the occurrence of postictal generalized EEG suppression (PGES), a potential biomarker of sudden unexpected death in epilepsy (SUDEP), in patients with focal epilepsy. METHODS: We retrospectively reviewed 34 consecutive patients with focal epilepsy, who presented with focal to bilateral tonic-clonic seizures (FBTCSs), 19 with PGES (PGES+) and 15 without PGES (PGES-), and 14 patients without epilepsy as controls. HRV spectrum analysis was performed for periods of 10 minutes during wakefulness, non-REM sleep, and REM sleep. HRV spectra consisted of high frequency (HF) and low frequency (LF) regions. Normalized HF representing parasympathetic activities and normalized LF were compared between the PGES+, PGES-, and control groups for each sleep stage. RESULTS: The PGES+ group showed significantly decreased normalized HF and increased normalized LF during non-REM sleep compared to the PGES- (P < 0.05) and control (P < 0.01) groups, but not during wakefulness or REM sleep. CONCLUSIONS: Abnormal interictal HRV during non-REM sleep, indicating abnormally decreased parasympathetic activities, was associated with PGES in patients with FBTCS. SIGNIFICANCE: This study proposes to further investigate the relation between decreased parasympathetic activities and PGES.

  49. Age-Related Recovery of Daily Living Activity After 1-Stage Complete Corpus Callosotomy: A Retrospective Analysis of 41 Cases. International-journal Peer-reviewed

    Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Nobukazu Nakasato

    Neurosurgery　90　(5)　547-551　2022/02/09

    DOI： 10.1227/NEU.0000000000001871 　

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    BACKGROUND: Recovery time after corpus callosotomy (CC) is known to be longer in elderly than in younger patients. OBJECTIVE: To evaluate the relationship between patient age and recovery time of activities of daily living (ADL) after 1-stage complete CC. METHODS: This study included 41 patients (22 women; aged 13 months-34 years, median 7 years) who underwent 1-stage complete CC for medically intractable seizures with drop attacks, infantile spasms, and/or bilaterally synchronized electroencephalographic discharges between August 2009 and April 2019. The timing of restart of competence in 5 ADL categories and surgical outcomes were recorded. RESULTS: Patients (1) restarted speech at 2.2 ± 1.3 (mean ± 2 standard deviations; range 1-5) days, (2) restarted replying with their own name on request at 5.5 ± 8.6 (2-33) days, (3) restarted oral intake at 1.6 ± 1.7 (1-11) days, (5) discontinued intravenous feeding at 6.0 ± 3.0 (2-16) days, and (5) restarted ambulation or wheelchair movement at 5.8 ± 3.4 (2-10) days. Younger patients showed significantly (P < .0223) earlier recovery of ambulation or wheelchair movement, but no age difference was found in the other 4 ADL categories. Overall seizure freedom was achieved in 5 patients, excellent (>80%) seizure reduction in 11, good (50%-80%) seizure reduction in 5, and poor (<50%) seizure reduction in 20. CONCLUSION: Early ADL recovery after 1-stage complete CC is favorable in both young and adult patients. These findings, with good surgical outcomes, will encourage more positive consideration of 1-stage complete CC in both pediatric and adult patients.

  50. Minimum standards for inpatient long-term video-electroencephalographic monitoring: A clinical practice guideline of the International League Against Epilepsy and International Federation of Clinical Neurophysiology. International-journal Peer-reviewed

    William O Tatum, Jayanti Mani, Kazutaka Jin, Jonathan J Halford, David Gloss, Firas Fahoum, Louis Maillard, Ian Mothersill, Sandor Beniczky

    Epilepsia　63　(2)　290-315　2022/02

    DOI： 10.1111/epi.16977 　

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    The objective of this clinical practice guideline is to provide recommendations on the indications and minimum standards for inpatient long-term video-electroencephalographic monitoring (LTVEM). The Working Group of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology develop guidelines aligned with the Epilepsy Guidelines Task Force. We reviewed published evidence using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) statement. We found limited high-level evidence aimed at specific aspects of diagnosis for LTVEM performed to evaluate patients with seizures and nonepileptic events. For classification of evidence, we used the Clinical Practice Guideline Process Manual of the American Academy of Neurology. We formulated recommendations for the indications, technical requirements, and essential practice elements of LTVEM to derive minimum standards used in the evaluation of patients with suspected epilepsy using GRADE (Grading of Recommendations Assessment, Development, and Evaluation). Further research is needed to obtain evidence about long-term outcome effects of LTVEM and to establish its clinical utility.

  51. Minimum standards for inpatient long-term video-EEG monitoring: A clinical practice guideline of the international league against epilepsy and international federation of clinical neurophysiology. International-journal Peer-reviewed

    William O Tatum, Jayanti Mani, Kazutaka Jin, Jonathan J Halford, David Gloss, Firas Fahoum, Louis Maillard, Ian Mothersill, Sandor Beniczky

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　134　111-128　2022/02

    DOI： 10.1016/j.clinph.2021.07.016 　

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    The objective of this clinical practice guideline is to provide recommendations on the indications and minimum standards for inpatient long-term video-electroencephalographic monitoring (LTVEM). The Working Group of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology develop guidelines aligned with the Epilepsy Guidelines Task Force. We reviewed published evidence using The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement. We found limited high-level evidence aimed at specific aspects of diagnosis for LTVEM performed to evaluate patients with seizures and nonepileptic events (see Table S1). For classification of evidence, we used the Clinical Practice Guideline Process Manual of the American Academy of Neurology. We formulated recommendations for the indications, technical requirements, and essential practice elements of LTVEM to derive minimum standards used in the evaluation of patients with suspected epilepsy using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation). Further research is needed to obtain evidence about long-term outcome effects of LTVEM and establish its clinical utility.

  52. Burden of seizures and comorbidities in patients with epilepsy: a survey based on the tertiary hospital-based Epilepsy Syndrome Registry in Japan. International-journal Peer-reviewed

    Yushi Inoue, Shin-Ichiro Hamano, Masaharu Hayashi, Hiroshi Sakuma, Shinichi Hirose, Atsushi Ishii, Ryoko Honda, Akio Ikeda, Katsumi Imai, Kazutaka Jin, Akiko Kada, Akiyoshi Kakita, Mitsuhiro Kato, Kensuke Kawai, Tamihiro Kawakami, Katsuhiro Kobayashi, Toyojiro Matsuishi, Takeshi Matsuo, Shin Nabatame, Nobuhiko Okamoto, Susumu Ito, Akihisa Okumura, Akiko Saito, Hideaki Shiraishi, Hiroshi Shirozu, Takashi Saito, Hidenori Sugano, Yukitoshi Takahashi, Hitoshi Yamamoto, Tetsuhiro Fukuyama, Ichiro Kuki

    Epileptic disorders : international epilepsy journal with videotape　24　(1)　82-94　2022/02/01

    DOI： 10.1684/epd.2021.1361 　

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    OBJECTIVE: To examine the current medical and psychosocial status of patients with epilepsy, aiming to facilitate appropriate application of the Intractable/Rare Diseases Act of Japan. METHODS: By analysing the cross-sectional data of patients registered in the tertiary hospital-based Epilepsy Syndrome Registry of Japan, we investigated the proportion of patients who met the severity criteria as defined by the Act (seizure frequency of at least once a month, or presence of intellectual/neurological/psychiatric symptoms, or both) and whether there are candidate syndrome/diseases to be added to the existing list in the Act. RESULTS: In total, 2,209 patients were registered. After excluding self-limited/idiopathic epilepsies, 1,851 of 2,110 patients (87.7%) met the severity criteria. The patients were classified into eight main epilepsy syndromes (594 patients), 20 groups based on aetiology (1,078 patients), and three groups without known aetiology (427 patients). Most of the groups classified by syndrome or aetiology had high proportions of patients satisfying the severity criteria (>90%), but some groups had relatively low proportions (<80%) resulting from favourable outcome of surgical therapy. Several small groups with known syndrome/aetiology await detailed analysis based on a sufficiently large enough number of patients registered, some of whom may potentially be added to the list of the Act. SIGNIFICANCE: The registry provides data to examine the usefulness of the severity criteria and list of diseases that are operationally defined by the Act. Most epilepsy patients with various syndromes/diseases and aetiology groups are covered by the Act but some are not, and the list of designated syndromes/diseases should be complemented by further amendments, as suggested by future research.

  53. Current medico-psycho-social conditions of patients with West syndrome in Japan. International-journal Peer-reviewed

    Shinsaku Yoshitomi, Shin-Ichiro Hamano, Masaharu Hayashi, Hiroshi Sakuma, Shinichi Hirose, Atsushi Ishii, Ryoko Honda, Akio Ikeda, Katsumi Imai, Kazutaka Jin, Akiko Kada, Akiyoshi Kakita, Mitsuhiro Kato, Kensuke Kawai, Tamihiro Kawakami, Katsuhiro Kobayashi, Toyojiro Matsuishi, Takeshi Matsuo, Shin Nabatame, Nobuhiko Okamoto, Susumu Ito, Akihisa Okumura, Akiko Saito, Hideaki Shiraishi, Hiroshi Shirozu, Takashi Saito, Hidenori Sugano, Yukitoshi Takahashi, Hitoshi Yamamoto, Tetsuhiro Fukuyama, Ichiro Kuki, Yushi Inoue

    Epileptic disorders : international epilepsy journal with videotape　23　(4)　579-589　2021/08/01

    DOI： 10.1684/epd.2021.1301 　

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    OBJECTIVE: To unveil current medical and psychosocial conditions of patients with West syndrome in Japan. METHODS: A cross-sectional analysis was performed in patients with West syndrome registered in the Rare Epilepsy Syndrome Registry (RES-R) of Japan. Furthermore, new-onset patients registered in the RES-R were observed prospectively and their outcomes after one and two years of follow-up were compared with data at onset. RESULTS: For the cross-sectional study, 303 patients with West syndrome were included. Seizures (such as spasms, tonic seizures and focal seizures) occurred daily in 69.3% of the patients at registration. Seizure frequency of less than one per year was observed in cases of unknown etiology (22.6%), genetic etiology (23.8%) and malformation of cortical development (MCD; 19.1%). Neurological findings were absent in 37.0%, but a high rate of abnormality was seen in patients with Aicardi syndrome, hypoxic-ischemic encephalopathy (HIE), genetic etiology and MCD other than focal cortical dysplasia, accompanied by a >50% rate of bedridden patients. Abnormal EEG was found in 96.7%, and CT/MRI was abnormal in 62.7%. Treatments included antiepileptic drug therapy (94.3%), hormonal therapy (72.6%), diet therapy (8.3%) and surgery (15.8%). Intellectual/developmental delay was present in 88.4%, and was more severe in patients with Aicardi syndrome, genetic etiology and HIE. Autism spectrum disorder was found in 13.5%. For the longitudinal study, 27 new-onset West syndrome patients were included. The follow-up study revealed improved seizure status after two years in 66.7%, but worsened developmental status in 55.6%, with overall improvement in 51.9%. SIGNIFICANCE: The study reveals the challenging neurological, physical and developmental aspects, as well as intractable seizures, in patients with West syndrome. More than a half of the children showed developmental delay after onset, even though seizures were reduced during the course of the disease.

  54. Acceptance of disability predicts quality of life in patients with epilepsy. International-journal Peer-reviewed

    Maimi Ogawa, Mayu Fujikawa, Kazutaka Jin, Yosuke Kakisaka, Takashi Ueno, Nobukazu Nakasato

    Epilepsy & behavior : E&B　120　107979-107979　2021/07

    DOI： 10.1016/j.yebeh.2021.107979 　

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    BACKGROUND: Acceptance of disability (AOD) is a key concept in rehabilitation psychology that enhances psychosocial adjustment of individuals with disability. However, the impact of AOD on well-being has never been examined for patients with epilepsy. The present study investigated whether AOD affects quality of life (QOL) in patients with epilepsy in the presence of other multiple aspects of epilepsy based on the biopsychosocial model. METHODS: We retrospectively reviewed 151 consecutive patients with epilepsy (77 men, aged 18-74 years) who underwent comprehensive assessment including long-term video-EEG monitoring, neuroimaging studies, and neuropsychological and psychosocial assessment in our epilepsy monitoring unit. Data were obtained from medical records and self-reported questionnaires. The outcome variable was QOL. Predictive variables included demographic characteristics, seizure-related variables (i.e., duration of epilepsy, seizure frequency, and number of antiepileptic drugs), psychological factors (i.e., AOD, depression, and self-stigma), and social factors (i.e., social support and education level). Acceptance of disability was measured by the Adaptation of Disability Scale-Revised (ADS-R), which we translated into Japanese with the original author's approval, and examined its internal consistency reliability. Data were analyzed using four hierarchical multiple regression analysis models. RESULTS: The mean ADS-R score was 80 (range 45-115). The predictors accounted for 42% of the variance in QOL (R2 = 0.45, ΔR2 = 0.42, F[8, 141] = 14.47, p = 0.00). Higher AOD (p < 0.01), higher social support (p < 0.01), and lower depression scores (p = 0.02) were found to contribute significantly to higher overall QOL. CONCLUSION: The present study revealed AOD as an important psychological concept, in addition to social support and depression as previously reported, to improve the QOL of patients with epilepsy. Acceptance of disability should be incorporated in the intervention to increase QOL of patients with epilepsy.

  55. Budget Impact Analysis of Treatment Flow Optimization in Epilepsy Patients: Estimating Potential Impacts with Increased Referral Rate to Specialized Care. International-journal Peer-reviewed

    Masaki Iwasaki, Takashi Saito, Akiko Tsubota, Tatsunori Murata, Yuta Fukuoka, Kazutaka Jin

    Journal of health economics and outcomes research　8　(1)　80-87　2021/06/10

    DOI： 10.36469/jheor.2021.24061 　

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    Objectives: We developed a Markov model to simulate a treatment flow of epilepsy patients who refer to specialized care from non-specialized care, and to surgery from specialized care for estimation of patient distributions and expenditures caused by increasing the referral rate for specialized care. Methods: This budget impact analysis of treatment flow optimization in epilepsy patients was performed as a long-term simulation using the Markov model by comparing the current treatment flow and the optimized treatment flow. In the model, we simulated the prognosis of new onset 5-year-old epilepsy patients (assuming to represent epilepsy occurring between 0 and 10 years of age) treated over a lifetime period. Direct costs of pharmacotherapies, management fees and surgeries are included in the analysis to evaluate the annual budget impact in Japan. Results: In the current treatment flow, the number of refractory patients treated with four drugs by non-specialized care were estimated as 8766 and yielded JPY5.8 billion annually. However, in the optimized treatment flow, the number of patients treated with four drugs by non-specialized care significantly decreased and who continued the monotherapy increased. The costs for the four-drug therapy by non-specialized care were eliminated. Hence cost-saving of JPY9.5 billion (-5% of the current treatment flow) in total national expenditures would be expected. Conclusion: This study highlights that any policy decision-making for referral optimization to specialized care in appropriate epilepsy patients would be feasible with a cost-savings or very few budget impacts. However, important information in the decision-making such as transition probability to the next therapy or excuse for sensitive limitations is not available currently. Therefore, further research with reliable data such as big data analysis or a national survey with real-world treatment patterns is needed.

  56. Magnetoencephalography to confirm epileptiform discharges mimicking small sharp spikes in temporal lobe epilepsy. International-journal Peer-reviewed

    Dai Agari, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Makoto Ishida, Ryuta Kawashima, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　132　(8)　1785-1789　2021/05/08

    DOI： 10.1016/j.clinph.2021.03.049 　

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    OBJECTIVE: To determine whether magnetoencephalography (MEG) can identify epileptiform discharges mimicking small sharp spikes (SSSs) on scalp electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE). METHODS: We retrospectively reviewed simultaneous scalp EEG and MEG recordings of 83 consecutive patients with TLE and 49 with extra-TLE (ETLE). RESULTS: SSSs in scalp EEG were detected in 15 (18.1%) of 83 TLE patients compared to only two (4.1%) of 49 ETLE patients (p = 0.029). Five of the 15 TLE patients had MEG spikes with concurrent SSSs in EEG, but neither of the 2 ETLE patients. Three of these 5 TLE patients had additional interictal epileptiform discharges (IEDs) in EEG and MEG. Equivalent current dipoles (ECDs) of MEG spikes with concurrent SSSs and IEDs showed no difference in temporal lobe localization and horizontal orientation, whereas ECD moments were smaller in MEG spikes with concurrent SSSs than those with IEDs. CONCLUSIONS: SSSs were more common in TLE than in ETLE. At least some morphologically diagnosed SSSs are true but low-amplitude epileptiform discharges in TLE which can be identified with simultaneous MEG. SIGNIFICANCE: Simultaneous MEG is useful to identify epileptiform discharges mimicking SSSs in patients with TLE.

  57. Initial delta and delayed theta/alpha pattern in the temporal region on ictal EEG suggests purely hippocampal epileptogenicity in patients with mesial temporal lobe epilepsy. International-journal Peer-reviewed

    Izumi Itabashi, Kazutaka Jin, Shiho Sato, Hiroyoshi Suzuki, Masaki Iwasaki, Yu Kitazawa, Yosuke Kakisaka, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　132　(3)　737-743　2021/03

    DOI： 10.1016/j.clinph.2020.11.041 　

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    OBJECTIVE: To determine whether the ictal scalp EEG findings suggest purely hippocampal epileptogenicity in patients with mesial temporal lobe epilepsy (mTLE) associated with hippocampal sclerosis (HS). METHODS: Twenty-three patients with mTLE with pathologically confirmed HS were divided into 12 with epileptogenicity only in the hippocampus (HS only group) and 11 with epileptogenicity in both the hippocampus and temporal neocortex or other locations (HS plus group), based on the combination of surgical procedures, postoperative outcome, and pathological findings. Sixteen underwent selective amygdalohippocampectomy (SelAH) and 7 received anterior temporal lobectomy. Ictal scalp EEG findings of 79 focal impaired awareness seizures were compared between the HS only and HS plus groups. We focused on the 1-4 Hz rhythmic delta activity at ictal onset followed by 5-9 Hz rhythmic theta/alpha activity 10-30 s after the onset in the temporal region. RESULTS: The initial delta and delayed theta/alpha (ID-DT) pattern was observed in 8 of 12 patients in the HS only group, but in none of 11 patients in the HS plus group (p < 0.01). CONCLUSIONS: ID-DT pattern on ictal EEG suggests purely hippocampal epileptogenicity in mTLE with HS. SIGNIFICANCE: Patients with the ID-DT pattern are likely to become seizure-free after SelAH.

  58. External validation of the Epilepsy Surgery Grading Scale in a Japanese cohort of patients with epilepsy. International-journal Peer-reviewed

    Franchesca Gabriel, Yosuke Kakisaka, Kazutaka Jin, Shin-Ichiro Osawa, Masaki Iwasaki, Teiji Tominaga, Nobukazu Nakasato

    Epileptic disorders : international epilepsy journal with videotape　23　(1)　104-110　2021/02/01

    DOI： 10.1684/epd.2021.1238 　

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    The Epilepsy Surgery Grading Scale (ESGS) is a simple method to predict the likelihood of a patient with epilepsy proceeding to surgery and achieving seizure freedom. Usefulness of the ESGS has been confirmed in established epilepsy centres in the United States and Belgium for adult patients with drug-resistant focal epilepsy undergoing presurgical evaluation. However, the applicability of the ESGS has not yet been evaluated in a wider range of epilepsy patients that may reflect the general spectrum of epilepsy. The present study validated the ESGS in a Japanese epilepsy centre in which admission-based comprehensive epilepsy studies were indicated beyond presurgical evaluation. This single-centre retrospective study included adult patients with epilepsy admitted to the Epilepsy Monitoring Unit from 2010 to June 2019. Patients were classified as ESGS Grade 1 (most favorable), Grade 2 (intermediate), and Grade 3 (least favourable). Patients were grouped into three cohorts: all patients, patients with drug-resistant focal epilepsy, and patients who underwent resective epilepsy surgery. We assessed progression to surgery and seizure freedom at one year after surgery. Of the 1,158 total admissions, 670 patients met the inclusion criteria and formed the total cohort. Of these, 435 (64.9%) had drug-resistant focal epilepsy and 78 (11.6%) proceeded to resective surgery. Overall, progression to surgery was observed in 41.3%, 16.6%, and 4.8% of patients with Grade 1, 2, and 3, respectively. In the surgical cohort, seizure freedom was observed in 85.2%, 65.2%, and 31.3% of patients with Grade 1, 2, and 3, respectively. Our results indicate that the ESGS is effective in predicting whether a patient proceeds to epilepsy surgery and achieves seizure freedom even in the general population of epilepsy patients, regardless of type or resistance to antiepileptic drugs.

  59. The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone. International-journal Peer-reviewed

    Yurika Numata-Uematsu, Mitsugu Uematsu, Rie Sakuraba, Masaki Iwasaki, Shinichiro Osawa, Kazutaka Jin, Nobukazu Nakasato, Shigeo Kure

    Frontiers in neurology　12　724417-724417　2021

    DOI： 10.3389/fneur.2021.724417 　

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    Objective: Accurate estimation of the epileptogenic zone (EZ) is essential for favorable outcomes in epilepsy surgery. Conventional ictal electrocorticography (ECoG) onset is generally used to detect the EZ but is insufficient in achieving seizure-free outcomes. By contrast, high-frequency oscillations (HFOs) could be useful markers of the EZ. Hence, we aimed to detect the EZ using interictal spikes and investigated whether the onset area of interictal spike-related HFOs was within the EZ. Methods: The EZ is considered to be included in the resection area among patients with seizure-free outcomes after surgery. Using a complex demodulation technique, we developed a method to determine the onset channels of interictal spike-related ripples (HFOs of 80-200 Hz) and investigated whether they are within the resection area. Results: We retrospectively examined 12 serial patients who achieved seizure-free status after focal resection surgery. Using the method that we developed, we determined the onset channels of interictal spike-related ripples and found that for all 12 patients, they were among the resection channels. The onset frequencies of ripples were in the range of 80-150 Hz. However, the ictal onset channels (evaluated based on ictal ECoG patterns) and ripple onset channels coincided in only 3 of 12 patients. Conclusions: Determining the onset area of interictal spike-related ripples could facilitate EZ estimation. This simple method that utilizes interictal ECoG may aid in preoperative evaluation and improve epilepsy surgery outcomes.

  60. Epilepsy in Five Long-term Survivors of Pineal Region Tumors. Peer-reviewed

    Yutaro Takayama, Kazutaka Jin, Shin-Ichiro Osawa, Masaki Iwasaki, Kazushi Ukishiro, Yosuke Kakisaka, Teiji Tominaga, Tetsuya Yamamoto, Nobukazu Nakasato

    NMC case report journal　8　(1)　773-780　2021

    DOI： 10.2176/nmccrj.cr.2021-0093 　

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    Cognitive decline is a well-known chronic side effect of multidisciplinary treatment of pineal region tumors, whereas epilepsy is an under-reported chronic consequence caused by multiple potential factors including radiotherapy, surgery, or chemotherapy. Some long-term survivors have suffered drug-resistant epilepsy after treatment, which impaired the quality of life. We report five consecutive patients with drug-resistant epilepsy after combined treatment of pineal region tumor (5 men, aged 21-42 years) among 1201 epilepsy patients who underwent comprehensive evaluation in our tertiary epilepsy center from 2011 to 2018. The comprehensive epilepsy evaluation included medical interview, long-term video electroencephalography (EEG) monitoring (VEM), and magnetic resonance (MR) imaging. The patients started to have seizures at 2-22 years after initial treatment for the tumor. Four of the five patients had focal impaired awareness seizures, whereas one patient had only visual aura. All patients had EEG seizures during VEM, which confirmed the diagnosis of focal epilepsy, but three patients had no interictal epileptiform discharges (IEDs). Two patients had diagnoses of focal epilepsy arising from the left occipital region based on ictal EEG findings. Both patients had MR imaging lesion in the left occipital lobe, radiation-induced cavernoma, or surgical injury. The remaining three patients showed poor localization of epileptogenic foci based on VEM and MR imaging. Drug-resistant epilepsy after multidisciplinary treatment of pineal region tumor is characterized by focal impaired awareness seizures with poorly localized EEG onset or rare interictal spikes.

  61. A patient with a 6q22.1 deletion and a phenotype of non-progressive early-onset generalized epilepsy with tremor. International-journal Peer-reviewed

    Kazuhiro Haginoya, Futoshi Sekiguchi, Mitsutoshi Munakata, Hiroyuki Yokoyama, Naomi Hino-Fukuyo, Mitsugu Uematsu, Kazutaka Jin, Kenichi Nagamatsu, Tadashi Ando, Noriko Miyake, Naomichi Matsumoto, Shigeo Kure

    Epilepsy & behavior reports　15　100405-100405　2021

    DOI： 10.1016/j.ebr.2020.100405 　

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    We report a patient with a 6q22.1 deletion, who presented with a rare syndrome of generalized epilepsy, myoclonic tremor, and intellectual disability. There was no clinical progression after follow-up for more than 10 years. Our report presents the genetic basis for a phenotype involving a non-progressive generalized epilepsy with tremor. The efficacy of valproic acid for seizure control and the partial efficacy of deep brain stimulation with propranolol for myoclonic tremor is detailed.

  62. Diagnostic yield of seizure recordings and neuroimaging in patients with focal epilepsy without interictal epileptiform discharges. International-journal Peer-reviewed

    Minori Suzuki, Kazutaka Jin, Yu Kitazawa, Mayu Fujikawa, Yosuke Kakisaka, Shiho Sato, Shunji Mugikura, Nobukazu Nakasato

    Epilepsy & behavior : E&B　112　107468-107468　2020/11

    DOI： 10.1016/j.yebeh.2020.107468 　

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    OBJECTIVE: Repeated routine electroencephalography (EEG) or even long-term video-EEG monitoring (VEM) does not always record interictal epileptiform discharges (IEDs) in some patients with epilepsy. The present study investigated whether focal seizures detected by VEM and focal abnormalities on neuroimaging are useful for the diagnosis of patients with focal epilepsy without IEDs. METHODS: We retrospectively reviewed 409 consecutive patients with focal epilepsy (207 men, aged 9 to 76 years) who underwent 4- or 5-day VEM, magnetic resonance imaging (MRI), and fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) for diagnosis to identify patients without IEDs. The occurrence of focal seizures during VEM and the presence of focal abnormalities on neuroimaging were investigated in those patients. The occurrence rate of seizures during VEM was investigated in patients with daily, weekly, monthly, and yearly seizure frequency based on history-taking. RESULTS: Ninety-five (23.2%) of 409 patients with focal epilepsy did not have IEDs. Fifty-five (57.9%) of the 95 patients had focal seizures during VEM. Fifty-four patients (56.8%) showed focal abnormalities compatible with seizure semiology on neuroimaging investigations. Neither seizure recordings nor neuroimaging abnormalities were seen in 16 (16.8%) of the 95 patients. The occurrence rate of seizures during VEM depended on the seizure frequency at history-taking. However, 28 (45.9%) of 61 patients with monthly and yearly seizure frequency had focal seizures during 4- or 5-day VEM with seizure induction. CONCLUSIONS: Video-EEG monitoring can detect focal seizures in patients with focal epilepsy but no IEDs. Comprehensive assessment including VEM and neuroimaging study is important for the diagnosis.

  63. Fifteen-year follow-up of a patient with a DHDDS variant with non-progressive early onset myoclonic tremor and rare generalized epilepsy. International-journal Peer-reviewed

    Noriko Togashi, Atsushi Fujita, Moriei Shibuya, Saki Uneoka, Takuya Miyabayashi, Ryo Sato, Yukimune Okubo, Wakaba Endo, Takehiko Inui, Kazutaka Jin, Naomichi Matsumoto, Kazuhiro Haginoya

    Brain & development　42　(9)　696-699　2020/10

    DOI： 10.1016/j.braindev.2020.06.011 　

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    BACKGROUND: Generalized epilepsy and tremor phenotypes have been reported in some genetic disorders. Among them benign adult familial myoclonus epilepsy (BAFME) has been confirmed as a clearly defined clinical and genetic entity. On the other hand, non-progressive tremor and generalized epilepsy phenotypes have also been reported in patients with DHDDS variants. CASE PRESENTATION: We report on a long term follow-up of patient with de novo missense variant of DHDDS, who revealed non progressive nature. This 18-year-old woman presented non-progressive tremor since her early infancy. She had rare seizures. Her tremor was considered as cortical myoclonic tremor with giant somatosensory evoked potentials. CONCLUSION: In patients with early onset, non-progressive tremor and rare generalized epilepsy phenotypes, DHDDS variants may be considered in the genetic differential diagnosis.

  64. Awake state-specific suppression of primary somatosensory evoked response correlated with duration of temporal lobe epilepsy. International-journal Peer-reviewed

    Makoto Ishida, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato

    Scientific reports　10　(1)　15895-15895　2020/09/28

    DOI： 10.1038/s41598-020-73051-x 　

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    Epilepsy is a network disease. The primary somatosensory cortex (S1) is usually considered to be intact, but could be subclinically disturbed based on abnormal functional connectivity in patients with temporal lobe epilepsy (TLE). We aimed to investigate if the S1 of TLE is abnormally modulated. Somatosensory evoked magnetic fields (SEFs) evoked by median nerve stimulation were recorded in each hemisphere of 15 TLE patients and 28 normal subjects. All responses were separately averaged in the awake state and light sleep using background magnetoencephalography. Latency and strength of the equivalent current dipole (ECD) was compared between the groups for the first (M1) and second peaks. Latencies showed no significant differences between the groups in either wakefulness or light sleep. ECD strengths were significantly lower in TLE patients than in controls only during wakefulness. The reduction of M1 ECD strength in the awake state is significantly correlated with duration of epilepsy. SEFs of TLE patients showed pure ECD strength reduction without latency delay. The phenomenon occurred exclusively during wakefulness, suggesting that a wakefulness-specific modulator of S1 is abnormal in TLE. Repetitive seizures may gradually insult the modulator of S1 distant from the epileptogenic network.

  65. Revisional Analysis of Electroencephalography and Magnetoencephalography Based on Comprehensive Epilepsy Conference

    Nobukazu Nakasato, Akitake Kanno, Makoto Ishida, Shin-ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin

    Fifty Years of Magnetoencephalography　191-197　2020/09/11

    Publisher: Oxford University Press

    DOI： 10.1093/oso/9780190935689.003.0013 　

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    <p>This chapter highlights the importance of the revised analysis of electroencephalography (EEG) and magnetoencephalography (MEG) spike source estimation based on comprehensive case conference discussion. It discusses two typical cases of localization-related epilepsy: case 1 as a simple situation and case 2 as a complicated situation. No “gold standard” for epileptic spike analysis in EEG or MEG has been established, so several methods must be adopted to achieve the most reasonable interpretation. However, such intense and revisional analyses may be too time-consuming in clinical settings and result in arbitrary conclusions. Therefore, the authors currently use a simple method first, that is, a single dipole model for the peak or preceding upward slope of unaveraged single spikes. In the following case conference, EEG and MEG data are reviewed with seizure semiology, anatomical magnetic resonance imaging (MRI), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). If all the findings almost agree, the clinical decision can be easily made. If not, revisional analysis of EEG/MEG is recommended using averaged spikes and principal component analysis models as well as distributed source models. In addition to EEG/MEG, the authors often order revisional analysis and additional MRI and FDG-PET studies after the conference. Even further history taking will be recommended if necessary.</p>

  66. Unilateral chronic pulsatile headache as the single manifestation of anti-MOG antibody-associated unilateral cerebral cortical encephalitis. International-journal Peer-reviewed

    Juichi Fujimori, Ryo Ogawa, Takaki Murata, Kazutaka Jin, Yukako Yazawa, Ichiro Nakashima

    Journal of neuroimmunology　346　577322-577322　2020/07/11

    DOI： 10.1016/j.jneuroim.2020.577322 　

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    Unilateral cerebral cortical encephalitis (UCCE) with myelin oligodendrocyte glycoprotein (MOG)-antibody comprises a new spectrum of disease entities generally presenting seizures. Here, we report a case of a young adult with anti-MOG antibody-associated UCCE who only presented persistent left pulsatile headache. Neurological examination revealed no deficits. Brain MRI showed a fluid-attenuated inversion recovery hyperintense lesion along the swollen left cerebral cortex. The patient was positive for anti-MOG antibodies. We diagnosed him with anti-MOG antibody-associated UCCE. Immediately after the administration of high-dose IV methylprednisolone, the headache diminished. Anti-MOG antibody-associated UCCE is a new differential diagnosis in patients with unilateral chronic pulsatile headache.

  67. Folic acid prescribed to prenatal and postpartum women who are also prescribed antiepileptic drugs in Japan: Data from a health administrative database. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    Birth defects research　112　(16)　1224-1233　2020/07/02

    DOI： 10.1002/bdr2.1748 　

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    BACKGROUND: The aim of this study was to evaluate the prevalence of folic acid (FA) prescription to prenatal and postpartum women who have also been prescribed antiepileptic drugs (AED) in Japan. METHODS: The data set used in this study included women covered by health insurance between 2005 and 2016. The prevalence of FA prescriptions between 180 days before pregnancy and 180 days postpartum was determined from a large administrative database, with the FA prescription classified according to dose and timing. RESULTS: For 33,941 women meeting our eligibility criteria, the mean maternal age at delivery was 32.3 years. At least one AED was prescribed to 225 of 33,941 women between 180 days before pregnancy and 180 days postpartum. FA was prescribed to 32 of 225 women (14.2%) during the same period. FA was prescribed to 8.8% of women with AED within 90 days before pregnancy and to 19.8% during the first trimester. FA was prescribed to 10.9% during the first 30 days after conception, all of whom were prescribed FA before the pregnancy. The maximum FA dose prescribed within 90 days before pregnancy was 5 mg/day for 5 of 12 women (41.7%) and >5 mg/day for 4 of 12 women (33.3%). The maximum FA dose prescribed during the first trimester was 5 mg/day for 14 of 22 women (63.6%) and >5 mg/day for 8 of 22 women (36.4%). CONCLUSIONS: The concurrent prescription of FA with AEDs in Japan was an uncommon therapeutic approach both before and during pregnancy.

  68. Sudden unexpected death in epilepsy in the bathtub. International-journal Peer-reviewed

    Hayashi K, Jin K, Nagamori C, Okanari K, Okanishi T, Homma Y, Iimura Y, Uda T, Takada L, Otsubo H

    Epilepsy & behavior : E&B　96　33-40　2019/07

    DOI： 10.1016/j.yebeh.2019.04.009 　

    ISSN： 1525-5050

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    OBJECTIVE: Sudden death in the bathtub occurs relatively frequently in Japan, particularly among elderly people. We hypothesize that sudden death in epilepsy occurring in the bathtub (SDEPB) can be distinguished from sudden death in nonepilepsy occurring in the bathtub (SDnonEPB), but is identical to sudden unexpected death in epilepsy (SUDEP). METHODS: Tokyo Medical Examiner's Office conducts postmortem examinations for all sudden and unexpected deaths in Tokyo. Clinical, social, and autopsy findings of 43 SDEPB were compared with 76 SDnonEPB, 50 SUDEP outside the bathtub, and Japanese forensic autopsy data as controls. RESULTS: Extension of the leg(s) outside the bathtub was seen in 33% of SDEPB, but none of SDnonEPB. Sitting position was seen less frequently in SDEPB (37%) than in SDnonEPB (64%). Lung weight and pleural effusion volume were significantly lower in SDEPB than in SDnonEPB. Age at death in SDEPB was significantly younger than that in SDnonEPB. Sudden death in epilepsy occurring in the bathtub showed no differences in lung weight and pleural effusion volume from SUDEP. Living with family was more frequent in SDEPB (73%) than in SUDEP (48%). Few antiepileptic drugs, infrequent seizures, and low rate of mental retardation were identical between SDEPB and SUDEP. Lung weight was significantly heavier in all three groups than in age- and sex- matched autopsy controls. CONCLUSIONS: Leg extension outside the bathtub, lower lung weight, and absence of pleural effusion distinguish SDEPB from SDnonEPB in elderly people. Sudden death in epilepsy occurring in the bathtub may represent a form of SUDEP occurring in the bathtub, rather than drowning despite submergence in the bathtub at discovery. Conditions for bathing require careful attention from physicians and relatives, even for patients with epilepsy with few medications and infrequent seizures, and without mental retardation.

  69. Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Masato Suzuka, Yasuko Ikeda-Sakai, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    Pharmacoepidemiology and drug safety　28　(6)　804-811　2019/06

    DOI： 10.1002/pds.4749 　

    ISSN： 1053-8569

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    PURPOSE: To evaluate the prevalence and patterns of prescriptions of antiepileptic drugs (AEDs) to prenatal and postpartum women in Japan using a large administrative database. METHODS: The dates of pregnancy onset and delivery were estimated using published algorithms and infant birth months. The prevalence of prescribed AEDs, the maximum dose of some AEDs, and the frequency of potential combination therapy with AEDs were evaluated for the 180 days before pregnancy onset, during pregnancy, and at 180-day postpartum. RESULTS: In total, 33 941 pregnant women were eligible for analysis. At least one AED was prescribed to 225 women (66 per 10 000 deliveries) between 180 days before pregnancy and 180-day postpartum and for 135 women (40 per 10 000 deliveries) during pregnancy. The prevalence of AED prescription declined during the first and second trimesters and increased in the third trimester and postpartum. Valproate was the most frequently prescribed drug, followed by clonazepam, lamotrigine, and carbamazepine. Nine (18.4%) of the 49 women with at least one prescription record of valproate in the first trimester were prescribed more than 600 mg/day of valproate. Concerning potential combination therapy, 40 (12 per 10 000 deliveries) concurrently received two or more AEDs between 180 days before pregnancy and 180-day postpartum, respectively, 31 (9 per 10 000 deliveries) women received these drugs during pregnancy. CONCLUSIONS: Various AEDs were prescribed to pregnant Japanese women. Women of reproductive age should select the appropriate AED before becoming pregnant, depending on the risk benefit profile.

  70. Perampanel-induced weight gain depends on level of intellectual disability and its serum concentration. International-journal Peer-reviewed

    Hirotaka Iwaki, Kazutaka Jin, Norio Sugawara, Nobukazu Nakasato, Sunao Kaneko

    Epilepsy research　152　1-6　2019/05

    DOI： 10.1016/j.eplepsyres.2019.02.011 　

    ISSN： 0920-1211

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    BACKGROUND: Body weight (BW) gain may be induced by perampanel (PER) administration, similar to the well-known adverse effects of valproic acid and gabapentin. Intellectual disability (ID) and serum PER concentration may be risk factors of BW gain. PURPOSE: This study investigated how ID and serum PER concentration are associated with PER-induced BW gain. METHODS: Subjects were 76 patients with epilepsy (41 men, aged 16-70 years). All patients were divided by intelligence quotient (IQ) into no ID (IQ ≥ 70, n = 24), mild to moderate ID (70 > IQ ≥35, n = 31), and severe to profound ID (IQ < 35, n = 21) groups. BW was measured before and 2, 4, 6, and 12 months after initiation of PER treatment, and serum PER concentration at 12 months. RESULTS: BW gains in the mild to moderate ID group at 4, 6, and 12 months were significantly (p <  0.05) higher than in the no ID and in the severe to profound ID groups. At 12 months, BW gain was associated with serum PER concentrations in the no ID (p =  0.034) and the mild to moderate ID (p =  0.001) groups but not in the severe to profound ID group. Multiple linear regression analysis found BW gain at 12 months was positively correlated with the mild to moderate ID group (β = 0.373, p =  0.002) and serum PER concentration (β = 0.241, p =  0.047). CONCLUSIONS: The mild to moderate ID group gained more BW than the no ID group, suggesting that PER-induced food intake was greater due to weaker behavioral control in the mild to moderate ID group. The present study suggests a linear correlation between serum PER concentration and BW change.

  71. Atrophy of the ipsilateral mammillary body in unilateral hippocampal sclerosis shown by thin-slice-reconstructed volumetric analysis. International-journal Peer-reviewed

    Yohei Morishita, Shunji Mugikura, Naoko Mori, Hajime Tamura, Shiho Sato, Toshiaki Akashi, Kazutaka Jin, Nobukazu Nakasato, Kei Takase

    Neuroradiology　61　(5)　515-523　2019/05

    DOI： 10.1007/s00234-019-02158-4 　

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    PURPOSE: Conventional volumetric analysis could not detect ipsilateral atrophy of the mammillary body in patients with unilateral hippocampal sclerosis. By using thin-slice-reconstructed volumetric analysis, we investigated whether the mammillary body volume is smaller on the hippocampal sclerosis side than in healthy subjects or the non-hippocampal sclerosis side. METHODS: This retrospective study included 45 patients with unilateral hippocampal sclerosis and 30 healthy subjects. Three-dimensional T1WI of 1 mm thicknesses were oversampled to a thickness of 0.2 mm (thin-slice-reconstructed images), and the mammillary bodies were segmented manually to determine mammillary body volume on each side. Mammillary body volumes on the hippocampal sclerosis side were compared with those in healthy subjects or the non-hippocampal sclerosis side. RESULTS: In patients with right hippocampal sclerosis, right mammillary body volume was both significantly smaller than that in healthy subjects (30.3 ± 10.3 vs. 43.3 ± 8.07 mm3, P < 0.001) and significantly smaller than the left mammillary body volume in each patient (30.3 ± 10.3 vs. 41.4 ± 10.1 mm3, P < 0.001). Similarly, in patients with left hippocampal sclerosis, left mammillary body volume was both significantly smaller than that in healthy subjects (37.7 ± 11.2 vs. 47.0 ± 8.65 mm3, P < 0.001) and significantly smaller than right mammillary body volume in each patient (37.7 ± 11.2 vs. 42.5 ± 7.78 mm3, P = 0.044). CONCLUSIONS: In this study, thin-slice-reconstructed volumetric analysis showed that, in patients with unilateral hippocampal sclerosis, mammillary body volume on the hippocampal sclerosis side is smaller than that in healthy subjects and the non-hippocampal sclerosis side.

  72. Teleconference-based education of epileptic seizure semiology. International-journal Peer-reviewed

    Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Yu Kitazawa, Nobukazu Nakasato

    Epilepsy research　145　73-76　2018/09

    DOI： 10.1016/j.eplepsyres.2018.06.007 　

    ISSN： 0920-1211

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    BACKGROUND: To evaluate whether a teleconference-based lecture provides similar understanding of seizure semiology to a face-to-face lecture for physicians. METHODS: Subjects were 66 physicians consisting of adult and pediatric neurologists, neurosurgeons, psychiatrists, and general practitioners. All attended the 30-minute lecture to introduce various types of seizure semiology using video-clips by one of the authors (Yo.K.) and then joined the comprehensive case conference which discussed three cases in 1.5 h. Group A received the lecture and conference using a teleconference system (N = 43) and Group B attended in person (N = 23) for geographical reasons. After the conference, 32 subjects (23 in Group A and nine in Group B) scored their own post-lecture understanding of seizure semiology using the four-point Likert scale from 1 (not at all) to 4 (very well) as well as the estimated pre-lecture score. Data was analyzed to assess whether their understanding was improved after the lecture. RESULTS: No significant difference was found in improvement of understanding after the lecture between Group A (43%) and Group B (22%; p = 0.42). Pre-lecture score of subjects with improved understanding was significantly lower (2.3 +/- 0.2) than those without improvement (3.7 +/- 0.1) (p < 0.05). SIGNIFICANCE: Teleconference-based lectures can be a useful tool to educate seizure semiology for physicians, especially at the inexperienced level, by overcoming geographical limitations.

  73. Predictive factors of higher drug load for seizure freedom in idiopathic generalized epilepsy: Comparison between juvenile myoclonic epilepsy and other types. International-journal Peer-reviewed

    Yu Kitazawa, Kazutaka Jin, Yosuke Kakisaka, Mayu Fujikawa, Fumiaki Tanaka, Nobukazu Nakasato

    Epilepsy research　144　20-24　2018/08

    DOI： 10.1016/j.eplepsyres.2018.04.009 　

    ISSN： 0920-1211

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    PURPOSE: Predictive factors of higher drug load for seizure freedom were investigated in idiopathic generalized epilepsy (IGE), focusing on the difference between juvenile myoclonic epilepsy (JME) and other types of IGE (non-JME IGE). METHODS: Twelve patients with JME and 12 patients with non-JME IGE, who achieved seizure freedom for 1 year or longer with appropriate antiepileptic drugs (AEDs) after video electroencephalography monitoring, were reviewed retrospectively. The sum of prescribed daily dose/defined daily dose ratio of all prescribed AEDs at the final visit was defined as total AED load. Patients requiring total AED load >1 were classified into the higher AED load group. Clinical background and the presence of interictal focal epileptiform abnormalities (FEAs) were compared between the higher and lower AED load groups. RESULTS: Higher AED load group of patients with JME had interictal FEAs and family history of epilepsy more frequently than the lower AED load group (p = 0.03 and p = 0.03). Similar comparison of patients with non-JME IGE showed no significant differences. CONCLUSIONS: The presence of interictal FEAs and a family history of epilepsy are significantly associated variables for higher AED load for seizure freedom in patients with JME, but not in patients with non-JME IGE.

  74. Topiramate-induced weight loss depends on level of intellectual disability in patients with epilepsy. International-journal Peer-reviewed

    Hirotaka Iwaki, Kazutaka Jin, Mayu Fujikawa, Nobukazu Nakasato, Sunao Kaneko

    Epilepsy & behavior : E&B　83　87-91　2018/06

    DOI： 10.1016/j.yebeh.2018.03.010 　

    ISSN： 1525-5050

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    OBJECTIVE: Intellectual disability (ID) is associated with weight gain caused by antiepileptic drugs such as valproic acid. The present study analyzed the relationship between ID and weight loss caused by topiramate (TPM). METHODS: Seventy-eight patients with epilepsy (35 women, aged 18 to 70years) were enrolled in this prospective study. Body weight was measured before and 1, 6, 12, and 18months after initiation of TPM treatment. Both patients and caregivers were provided information about TPM-related weight loss. The patients were divided into the group with no or mild ID (intelligence quotient >50) and the group with moderate to profound ID (intelligence quotient ≤50). RESULTS: Body weight of both groups significantly decreased until 6months but stabilized after 12months. Weight loss at 6, 12, and 18months was significantly greater in the group with no or mild ID than in the group with moderate to profound ID. Body weight change at 18months was correlated with intellectual levels (β=0.274, p=0.011) and baseline body mass index (β=-0.322, p=0.002) by multiple linear regression analysis. CONCLUSIONS: The present study suggests that the pattern of weight loss during TPM administration differs according to intellectual levels. Patients with ID maintained their body weight. Weight loss due to TPM might be weakened by caregiver control of food intake or inactivity.

  75. Surgical treatment of intractable epilepsy presenting with hyperkinetic seizures originating in the frontal lobe

    Osawa, S., Iwasaki, M., Takayama, Y., Jin, K., Nakasato, N., Tominaga, T.

    Japanese Journal of Neurosurgery　27　(10)　2018

    DOI： 10.7887/jcns.27.764 　

  76. Stressful medical explanation may cause syncope in patients with emotion-triggered neurocardiogenic syncope. International-journal Peer-reviewed

    Kazuhiro Kato, Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Miki Nakamura, Natsumi Suzuki, Masateru Kondo, Koji Fukuda, Hiroaki Shimokawa, Nobukazu Nakasato

    Pacing and clinical electrophysiology : PACE　41　(1)　96-98　2018/01

    DOI： 10.1111/pace.13199 　

    ISSN： 0147-8389

  77. Apparently diffuse epileptic abnormalities caused by a small cavernous malformation: a surgical case report. Peer-reviewed

    Ninomiya A, Iwasaki M, Kakisaka Y, Jin K, Nakasato N, Tominaga T

    Epilepsy & Seizure　10　(1)　107-113　2018/01

  78. [A surgical case of mesial temporal lobe epilepsy associated with hippocampal sclerosis and traumatic neocortical lesion]. Peer-reviewed

    Yu Kitazawa, Kazutaka Jin, Masaki Iwasaki, Hiroyoshi Suzuki, Fumiaki Tanaka, Nobukazu Nakasato

    Rinsho shinkeigaku = Clinical neurology　57　(11)　698-704　2017/11/25

    DOI： 10.5692/clinicalneurol.cn-001029 　

    ISSN： 0009-918X

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    A 26-year-old right-handed woman, with a history of left temporal lobe contusion caused by a fall at the age of 9 months, started to have complex partial seizures with oral automatism at the age of 7 years. The seizures occurred once or twice a month despite combination therapy with several antiepileptic agents. Her history and imaging studies suggested the diagnosis of epilepsy arising from traumatic neocortical temporal lesion. Comprehensive assessment including long-term video EEG monitoring, MRI, FDG-PET, MEG, and neuropsychological evaluation was performed at the age of 26 years. The diagnosis was left mesial temporal lobe epilepsy associated with hippocampal atrophy and traumatic temporal cortical lesion. The patient was readmitted for surgical treatment at the age of 27 years. Intracranial EEG monitoring showed that ictal discharges started in the left hippocampus and spread to the traumatic lesion in the left posterior superior temporal gyrus 10 seconds after the onset. This case could not be classified as dual pathology exactly, because the traumatic left temporal cortical lesion did not show independent epileptogenicity. However, the traumatic lesion was highly likely to be the source of the epileptogenicity, and she had right hemispheric dominance for language and functional deterioration in the whole temporal cortex. Therefore, left amygdalo-hippocampectomy and left temporal lobectomy including the traumatic lesion were performed according to the diagnosis of dual pathology. Subsequently, she remained seizure-free for 3 years. Comprehensive assessment of seizure semiology, neurophysiology, neuroradiology, and neuropsychology is important to determine the optimum therapeutic strategies for drug-resistant epilepsy.

  79. Magnetoencephalographic Identification of Epileptic Focus in Children With Generalized Electroencephalographic (EEG) Features but Focal Imaging Abnormalities Peer-reviewed

    Garima Shukla, Jin Kazutaka, Ajay Gupta, John Mosher, Stephen Jones, Andreas Alexopoulos, Richard C. Burgess

    JOURNAL OF CHILD NEUROLOGY　32　(12)　981-995　2017/10

    DOI： 10.1177/0883073817724903 　

    ISSN： 0883-0738

    eISSN： 1708-8283

  80. PNES around the world: Where we are now and how we can close the diagnosis and treatment gaps-an ILAE PNES Task Force report. Peer-reviewed

    Kanemoto K, LaFrance WC Jr, Duncan R, Gigineishvili D, Park SP, Tadokoro Y, Ikeda H, Paul R, Zhou D, Taniguchi G, Kerr M, Oshima T, Jin K, Reuber M

    Epilepsia open　2　(3)　307-316　2017/09

    DOI： 10.1002/epi4.12060 　

  81. Disseminated cerebral amyloid angiopathy-related inflammation manifesting as non-convulsive status epilepticus

    Yasuaki Watanabe, Hiroshi Kuroda, Shuhei Nishiyama, Junpei Kobayashi, Kazutaka Jin, Masashi Aoki

    Neurology and Clinical Neuroscience　5　(2)　65-67　2017/03

    Publisher: Wiley

    DOI： 10.1111/ncn3.12104 　

    ISSN： 2049-4173

  82. [Ictal Speech Manifesting as Sleep Talking: A Case Report]. Peer-reviewed

    Takehiro Suzuki, Yosuke Kakisaka, Yu Kitazawa, Kazutaka Jin, Shiho Sato, Masaki Iwasaki, Mayu Fujikawa, Yoshiyuki Nishio, Akitake Kanno, Nobukazu Nakasato

    Brain and nerve = Shinkei kenkyu no shinpo　69　(2)　167-171　2017/02

    DOI： 10.11477/mf.1416200657 　

    ISSN： 1881-6096

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    We present a 28-year-old female patient whose epilepsy started at the age of 19. MRI showed right perisylvian polymicrogyria. She exhibited various seizure symptoms, such as somatosensory aura involving the left leg, dyscognitive seizures, and amnesic seizures. Her mother indicated that the patient sometimes had "sleep talking", which was associated with presence of epileptic seizures of the next day. Long-term video electroencephalography (EEG) revealed that her episodes of "sleep talking" were epileptic events, specifically ictal speech, originating in the right hemisphere. The present case demonstrates the importance of considering "sleep talk" as an epileptic symptom. Careful history taking is fundamental to carry patients with possibly pathological "sleep talk" to the long-term video EEG, which will contribute correct diagnosis and treatment. (Received August 16, 2016; Accepted September 9, 2016; Published February 1, 2017).

  83. Differences in sleep architecture between left and right temporal lobe epilepsy Peer-reviewed

    Miki Nakamura, Kazutaka Jin, Kazuhiro Kato, Hisashi Itabashi, Masaki Iwasaki, Yosuke Kakisaka, Nobukazu Nakasato

    NEUROLOGICAL SCIENCES　38　(1)　189-192　2017/01

    DOI： 10.1007/s10072-016-2731-6 　

    ISSN： 1590-1874

    eISSN： 1590-3478

  84. Levetiracetam improves symptoms of multiple chemical sensitivity: Case report. Peer-reviewed

    Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Yu Kitazawa, Kazuhiro Kato, Nobukazu Nakasato

    The journal of medical investigation : JMI　64　(3.4)　296-298　2017

    DOI： 10.2152/jmi.64.296 　

    ISSN： 1343-1420

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    Multiple chemical sensitivity (MCS) is a disorder of unknown etiology with no effective treatment. Many clinicians accept that a diagnosis of somatic symptoms disorder (SSD) is an appropriate diagnostic category for MCS. We found that administration of levetiracetam improved recurrent symptoms of MCS in a patient. A 23-year-old female presented with recurrent multiple symptoms of musculoskeletal, airway or mucous membrane, heart/chest-related, gastrointestinal, cognitive, affective, neuromuscular, head-related, and skin-related induced by exposure to diesel or gas engine exhaust, tobacco smoke, insecticide, gasoline, paint or paint thinner, cleaning products, fragrances, tar or asphalt, nail polish or hairspray, and new furnishings. Gastrointestinal, cognitive, and skin-related symptoms were precipitated by some food additives. She suffered partial seizures from the age of 17 years, and was diagnosed with right parietal lobe epilepsy. Administration of levetiracetam (250 mg/day) eliminated her MCS symptoms. Levetiracetam reduces the release of presynaptic neurotransmitter including glutamate by binding to presynaptic vesicle protein. A recent study established the presence of glutamatergic overactivation in somatization disorder, a form of SSD. Our case may indicate that a subset of patients with SSD have glutamatergic overactivation, which levetiracetam can normalize. J. Med. Invest. 64: 296-298, August, 2017.

  85. T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus Peer-reviewed

    Shiho Sato, Masaki Iwasaki, Hiroyoshi Suzuki, Shunji Mugikura, Kazutaka Jin, Teiji Tominaga, Kei Takase, Shoki Takahashi, Nobukazu Nakasato

    EPILEPSY RESEARCH　126　1-9　2016/10

    DOI： 10.1016/j.eplepsyres.2016.06.001 　

    ISSN： 0920-1211

    eISSN： 1872-6844

  86. Ictal pattern on scalp EEG at onset of seizure in temporal lobe epilepsy: Old and new problems for epileptologists Peer-reviewed

    Kazutaka Jin, Nobukazu Nakasato

    CLINICAL NEUROPHYSIOLOGY　127　(2)　987-988　2016/02

    DOI： 10.1016/j.clinph.2015.07.023 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  87. Rhythmic and periodic EEG patterns of 'ictal-interictal uncertainty': Red flag to switch from routine to continuous EEG monitoring Peer-reviewed

    Kazutaka Jin, Nobukazu Nakasato

    CLINICAL NEUROPHYSIOLOGY　127　(2)　993-993　2016/02

    DOI： 10.1016/j.clinph.2015.11.014 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  88. Adult epilepsy

    Kazutaka Jin, Nobukazu Nakasato

    Clinical Applications of Magnetoencephalography　175-185　2016/01/01

    DOI： 10.1007/978-4-431-55729-6_10 　

  89. Clinical profiles for seizure remission and developmental gains after total corpus callosotomy Peer-reviewed

    Masaki Iwasaki, Mitsugu Uematsu, Naomi Hino-Fukuyo, Shin-ichiro Osawa, Yoshiteru Shimoda, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    BRAIN & DEVELOPMENT　38　(1)　47-53　2016/01

    DOI： 10.1016/j.braindev.2015.04.010 　

    ISSN： 0387-7604

    eISSN： 1872-7131

  90. High frequency oscillations are less frequent but more specific to epileptogenicity during rapid eye movement sleep Peer-reviewed

    Rie Sakuraba, Masaki Iwasaki, Eiichi Okumura, Kazutaka Jin, Yosuke Kakisaka, Kazuhiro Kato, Teiji Tominaga, Nobukazu Nakasato

    CLINICAL NEUROPHYSIOLOGY　127　(1)　179-186　2016/01

    DOI： 10.1016/j.clinph.2015.05.019 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  91. Verbal Dominant Memory Impairment and Low Risk for Post-operative Memory Worsening in Both Left and Right Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis Peer-reviewed

    Amr Farid Khalil, Masaki Iwasaki, Yoshiyuki Nishio, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    NEUROLOGIA MEDICO-CHIRURGICA　56　(11)　716-723　2016

    DOI： 10.2176/nmc.oa.2016-0004 　

    ISSN： 0470-8105

    eISSN： 1349-8029

  92. Non-invasive Evaluation for Epilepsy Surgery Peer-reviewed

    Masaki Iwasaki, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    NEUROLOGIA MEDICO-CHIRURGICA　56　(10)　632-640　2016

    DOI： 10.2176/nmc.ra.2016-0186 　

    ISSN： 0470-8105

    eISSN： 1349-8029

  93. Resection of focal cortical dysplasia located in the upper pre-central gyrus Peer-reviewed

    Samer Serag Eldin, Masaki Iwasaki, Yoshiyuki Nishio, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    EPILEPTIC DISORDERS　17　(4)　479-484　2015/12

    DOI： 10.1684/epd.2015.0771 　

    ISSN： 1294-9361

    eISSN： 1950-6945

  94. Treatment strategy for adult epilepsy: A current approach Peer-reviewed

    Kazutaka Jin

    Brain and Nerve　67　(8)　1043-1049　2015/08/01

    Publisher: Igaku-Shoin Ltd

    DOI： 10.11477/mf.1416200251 　

    ISSN： 1881-6096

  95. Obsessive-compulsive behavior induced by levetiracetam. International-journal Peer-reviewed

    Mayu Fujikawa, Yuri Kishimoto, Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Nobukazu Nakasato

    Journal of child neurology　30　(7)　942-4　2015/06

    DOI： 10.1177/0883073814541471 　

    ISSN： 0883-0738

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    A novel antiepileptic drug, levetiracetam, has been reported to cause several psychiatric adverse effects in spite of its effectiveness on epilepsy. However, a possible relationship between levetiracetam and obsessive-compulsive behavior has only been reported in a few studies with adult epilepsy patients. We treated a pediatric patient with epilepsy without past or family history of psychiatric disorder. Levetiracetam was started to control generalized tonic-clonic seizure. Two months after initiation of levetiracetam with favorable seizure control, she started to show an obsessive-compulsive behavior such as repetitive checking of her back, pants, and chair. Based on the course of its appearance, levetiracetam administration was identified as a possible cause. After termination of levetiracetam, her obsessive-compulsive behavior completely disappeared with reappearance of seizures. This case provides clear evidence that levetiracetam may cause obsessive-compulsive behavior even in a pediatric epilepsy patient without psychiatric background, possibly mediated by modulation of the glutamate system by levetiracetam.

  96. [A case of focal epilepsy manifesting multiple psychiatric auras]. Peer-reviewed

    Michinori Ezura, Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Mayu Fujikawa, Masashi Aoki, Nobukazu Nakasato

    Brain and nerve = Shinkei kenkyu no shinpo　67　(1)　105-9　2015/01

    DOI： 10.11477/mf.1416200093 　

    ISSN： 1881-6096

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    We present a case of epilepsy with multiple types of focal seizures that were misdiagnosed as psychiatric disorders. A 20-year-old female patient presented with a variety of episodes, including loss of consciousness, deja vu, fear, delusion of possession, violent movements, and generalized convulsions. Each of these symptoms appeared in a stereotypic manner. She was initially diagnosed with a psychiatric disorder and treated with psychoactive medications, which had no effect. Long-term video electroencephalography revealed that her episodes of violent movement with impaired consciousness and secondarily generalized seizure were epileptic events originating in the right hemisphere. High-field brain magnetic resonance imaging for detecting subtle lesions revealed bilateral lesions from periventricular nodular heterotopia. Her final diagnosis was right hemispheric focal epilepsy. Carbamazepine administration was started, which successfully controlled all seizures. The present case demonstrates the pitfall of diagnosing focal epilepsy when it presents with multiple types of psychiatric aura. Epilepsy should thus be included in differential diagnoses, considering the stereotypic nature of symptoms, to avoid misdiagnosis.

  97. Interhemispheric Vertical Hemispherotomy: A Single Center Experience Peer-reviewed

    Masaki Iwasaki, Mitsugu Uematsu, Shin-ichiro Osawa, Yoshiteru Shimoda, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    PEDIATRIC NEUROSURGERY　50　(5)　295-300　2015

    DOI： 10.1159/000437145 　

    ISSN： 1016-2291

    eISSN： 1423-0305

  98. [Clinical characteristics of four patients with temporal lobe epilepsy associated with elevated anti-GAD antibodies]. Peer-reviewed

    Tetsuya Akaishi, Kazutaka Jin, Kazuhiro Kato, Hisashi Itabashi, Tatsuro Misu, Maki Tateyama, Masaki Iwasaki, Masashi Aoki, Nobukazu Nakasato

    Rinsho shinkeigaku = Clinical neurology　55　(11)　804-9　2015

    DOI： 10.5692/clinicalneurol.cn-000740 　

    ISSN： 0009-918X

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    Anti-glutamic acid decarboxylase (GAD) antibodies are known to be associated with insulin-dependent diabetes mellitus (IDDM), stiff-person syndrome, and other neurological symptoms including temporal lobe epilepsy (TLE), known as autoimmune epilepsy. We treated four patients with TLE who had elevated titers of serum anti-GAD antibody (anti-GAD-Ab), higher than 100 U/ml. Three of the four patients started to have epileptic seizures in their 5th or 6th decade. Characteristic symptoms suggesting encephalitis or encephalopathy were absent at onset of these symptoms, which led to delayed diagnosis. All four patients developed two or three of cerebellar ataxia, neuropsychological impairment, and IDDM, by several years or decades after onset of TLE, even after seizure freedom in two patients. These abnormalities were indicators for suspecting the involvement of anti-GAD-Ab in the pathogenesis. Anti-GAD-Ab levels in the cerebrospinal fluid (CSF) were measured, which detected elevated CSF/serum anti-GAD-Ab ratio (≥ 1.0), suggesting intrathecal anti-GAD-Ab synthesis, in three of the four patients. The TLE symptoms were somewhat prolonged, but three of the four patients eventually achieved seizure freedom after immunotherapies with combinations of two or three anti-epileptic drugs. Serum anti-GAD Ab is recommended to be measured in patients with middle-aged onset TLE. Moreover, immune-modulating therapies including steroid pulse and intravenous immunoglobulin therapies could have ameliorated neurological complications, even in the chronic phase.

  99. Electro-and magneto-encephalographic spike source localization of small focal cortical dysplasia in the dorsal peri-rolandic region Peer-reviewed

    Hisashi Itabashi, Kazutaka Jin, Masaki Iwasaki, Eiichi Okumura, Akitake Kanno, Kazuhiro Kato, Teiji Tominaga, Ryuta Kawashima, Nobukazu Nakasato

    CLINICAL NEUROPHYSIOLOGY　125　(12)　2358-2363　2014/12

    DOI： 10.1016/j.clinph.2014.02.028 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  100. Earlier tachycardia onset in right than left mesial temporal lobe seizures Peer-reviewed

    Kazuhiro Kato, Kazutaka Jin, Hisashi Itabashi, Masaki Iwasaki, Yosuke Kakisaka, Masashi Aoki, Nobukazu Nakasato

    NEUROLOGY　83　(15)　1332-1336　2014/10

    DOI： 10.1212/WNL.0000000000000864 　

    ISSN： 0028-3878

    eISSN： 1526-632X

  101. Long-cherished dreams for epileptologists and clinical neurophysiologists: Automatic seizure detection in long-term scalp EEG Peer-reviewed

    Kazutaka Jin, Nobukazu Nakasato

    CLINICAL NEUROPHYSIOLOGY　125　(7)　1289-1290　2014/07

    DOI： 10.1016/j.clinph.2013.12.105 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  102. Temporal intermittent rhythmic delta activity and abdominal migraine Peer-reviewed

    Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Nobukazu Nakasato

    NEUROLOGICAL SCIENCES　35　(4)　627-628　2014/04

    DOI： 10.1007/s10072-013-1625-0 　

    ISSN： 1590-1874

    eISSN： 1590-3478

  103. Seizure Freedom after Lamotrigine Rash: A Peculiar Phenomenon in Epilepsy Peer-reviewed

    Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Nobukazu Nakasato

    INTERNAL MEDICINE　53　(21)　2521-2522　2014

    DOI： 10.2169/internalmedicine.53.2284 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  104. Time-varying inter-hemispheric coherence during corpus callosotomy Peer-reviewed

    Eiichi Okumura, Masaki Iwasaki, Rie Sakuraba, Izumi Itabashi, Shin-ichiro Osawa, Kazutaka Jin, Hisashi Itabashi, Kazuhiro Kato, Akitake Kanno, Teiji Tominaga, Nobukazu Nakasato

    CLINICAL NEUROPHYSIOLOGY　124　(11)　2091-2100　2013/11

    DOI： 10.1016/j.clinph.2013.05.004 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  105. Utility of temporally-extended signal space separation algorithm for magnetic noise from vagal nerve stimulators Peer-reviewed

    Yosuke Kakisaka, John C. Mosher, Zhong I. Wang, Kazutaka Jin, Anne-Sophie Dubarry, Andreas V. Alexopoulos, Richard C. Burgess

    CLINICAL NEUROPHYSIOLOGY　124　(7)　1277-1282　2013/07

    DOI： 10.1016/j.clinph.2012.03.082 　

    ISSN： 1388-2457

  106. Implanted medical devices or other strong sources of interference are not barriers to magnetoencephalographic recordings in epilepsy patients Peer-reviewed

    Kazutaka Jin, Andreas V. Alexopoulos, John C. Mosher, Richard C. Burgess

    CLINICAL NEUROPHYSIOLOGY　124　(7)　1283-1289　2013/07

    DOI： 10.1016/j.clinph.2013.04.004 　

    ISSN： 1388-2457

  107. Parental satisfaction and seizure outcome after corpus callosotomy in patients with infantile or early childhood onset epilepsy Peer-reviewed

    Masaki Iwasaki, Mitsugu Uematsu, Tojo Nakayama, Naomi Hino-Fukuyo, Yuko Sato, Tomoko Kobayashi, Kazuhiro Haginoya, Shin-ichiro Osawa, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY　22　(4)　303-305　2013/05

    DOI： 10.1016/j.seizure.2013.01.005 　

    ISSN： 1059-1311

  108. Magnetic source imaging and ictal SPECT in MRI-negative neocortical epilepsies: Additional value and comparison with intracranial EEG Peer-reviewed

    Felix Schneider, Z. Irene Wang, Andreas V. Alexopoulos, Salah Almubarak, Yosuke Kakisaka, Kazutaka Jin, Dileep Nair, John C. Mosher, Imad M. Najm, Richard C. Burgess

    EPILEPSIA　54　(2)　359-369　2013/02

    DOI： 10.1111/epi.12004 　

    ISSN： 0013-9580

  109. Intra-operative Monitoring of Inter-hemispheric EEG Connectivity During Corpus Callosotomy Peer-reviewed

    Iwasaki Masaki, Okumura Eiichi, Sakuraba Rie, Itabashi Izumi, Osawa Shin-ichiro, Jin Kazutaka, Nakasato Nobukazu, Tominaga Teiji

    STEREOTACTIC AND FUNCTIONAL NEUROSURGERY　91　43　2013

    ISSN： 1011-6125

  110. Imag(in)ing seizure propagation: MEG-guided interpretation of epileptic activity from a deep source Peer-reviewed

    Zhong I. Wang, Kazutaka Jin, Yosuke Kakisaka, John C. Mosher, William E. Bingaman, Prakash Kotagal, Richard C. Burgess, Imad M. Najm, Andreas V. Alexopoulos

    HUMAN BRAIN MAPPING　33　(12)　2797-2801　2012/12

    DOI： 10.1002/hbm.21401 　

    ISSN： 1065-9471

  111. Magnetoencephalography in fronto-parietal opercular epilepsy Peer-reviewed

    Yosuke Kakisaka, Masaki Iwasaki, Andreas V. Alexopoulos, Rei Enatsu, Kazutaka Jin, Zhong I. Wang, John C. Mosher, Anne-Sophie Dubarry, Dileep R. Nair, Richard C. Burgess

    EPILEPSY RESEARCH　102　(1-2)　71-77　2012/11

    DOI： 10.1016/j.eplepsyres.2012.05.003 　

    ISSN： 0920-1211

  112. Interconnections in superior temporal cortex revealed by musicogenic seizure propagation Peer-reviewed

    Z. Irene Wang, Kazutaka Jin, Yosuke Kakisaka, Richard C. Burgess, Jorge A. Gonzalez-Martinez, Shuang Wang, Susumu Ito, John C. Mosher, Stephen Hantus, Andreas V. Alexopoulos

    JOURNAL OF NEUROLOGY　259　(10)　2251-2254　2012/10

    DOI： 10.1007/s00415-012-6556-9 　

    ISSN： 0340-5354

  113. Use of simultaneous depth and MEG recording may provide complementary information regarding the epileptogenic region Peer-reviewed

    Yosuke Kakisaka, Yuichi Kubota, Zhong I. Wang, Zhe Piao, John C. Mosher, Jorge Gonzalez-Martinez, Kazutaka Jin, Andreas V. Alexopoulos, Richard C. Burgess

    EPILEPTIC DISORDERS　14　(3)　298-303　2012/09

    DOI： 10.1684/epd.2012.0517 　

    ISSN： 1294-9361

  114. Correlations between ictal propagation and response to electrical cortical stimulation: A cortico-cortical evoked potential study Peer-reviewed

    Rei Enatsu, Kazutaka Jin, Sherif Elwan, Yuichi Kubota, Zhe Piao, Timothy O'Connor, Karl Horning, Richard C. Burgess, William Bingaman, Dileep R. Nair

    EPILEPSY RESEARCH　101　(1-2)　76-87　2012/08

    DOI： 10.1016/j.eplepsyres.2012.03.004 　

    ISSN： 0920-1211

  115. Complete remission of seizures after corpus callosotomy Peer-reviewed

    Masaki Iwasaki, Mitsugu Uematsu, Yuko Sato, Tojo Nakayama, Kazuhiro Haginoya, Shin-ichiro Osawa, Hisashi Itabashi, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    JOURNAL OF NEUROSURGERY-PEDIATRICS　10　(1)　7-13　2012/07

    DOI： 10.3171/2012.3.PEDS11544 　

    ISSN： 1933-0707

  116. Voxel-based morphometric MRI post-processing in MRI-negative focal cortical dysplasia followed by simultaneously recorded MEG and stereo-EEG Peer-reviewed

    Z. I. Wang, S. E. Jones, A. J. Ristic, C. Wong, Y. Kakisaka, K. Jin, F. Schneider, J. A. Gonzalez-Martinez, J. C. Mosher, D. Nair, R. C. Burgess, I. M. Najm, A. V. Alexopoulos

    EPILEPSY RESEARCH　100　(1-2)　188-193　2012/06

    DOI： 10.1016/j.eplepsyres.2012.02.011 　

    ISSN： 0920-1211

  117. Magnetic source imaging in non-lesional neocortical epilepsy: Additional value and comparison with ICEEG Peer-reviewed

    Felix Schneider, Andreas V. Alexopoulos, Zhong Wang, Salah Almubarak, Yosuke Kakisaka, Kazutaka Jin, Dileep Nair, John C. Mosher, Imad M. Najm, Richard C. Burgess

    EPILEPSY & BEHAVIOR　24　(2)　234-240　2012/06

    DOI： 10.1016/j.yebeh.2012.03.029 　

    ISSN： 1525-5050

  118. [Recent advances in epilepsy management]. Invited

    Kazutaka Jin, Nobukazu Nakasato, Masaki Iwasaki, Teiji Tominaga

    No shinkei geka. Neurological surgery　40　(1)　5-14　2012/01

    ISSN： 0301-2603

  119. CSF PROTEIN BIOMARKERS FOR PROXIMAL AXONAL DAMAGE IMPROVE PROGNOSTIC ACCURACY IN THE ACUTE PHASE OF GUILLAIN-BARRE SYNDROME Peer-reviewed

    A. Petzold, J. Brettschneider, K. Jin, G. Keir, N. M. F. Murray, N. P. Hirsch, Y. Itoyama, M. M. Reilly, A. Takeda, H. Tumani

    MUSCLE & NERVE　40　(1)　42-49　2009/07

    DOI： 10.1002/mus.21239 　

    ISSN： 0148-639X

  120. A CASE OF NMO SEROPOSITIVE FOR AQUAPORIN-4 ANTIBODY MORE THAN 10 YEARS BEFORE ONSET Peer-reviewed

    S. Nishiyama, T. Ito, T. Misu, T. Takahashi, A. Kikuchi, N. Suzuki, K. Jin, M. Aoki, K. Fujihara, Y. Itoyama

    NEUROLOGY　72　(22)　1960-1961　2009/06

    DOI： 10.1212/WNL.0b013e3181a82621 　

    ISSN： 0028-3878

  121. Neuromagnetic localization of spike sources in perilesional, contralateral mirror, and ipsilateral remote areas in patients with cavernoma Peer-reviewed

    Kazutaka Jin, Nobukazu Nakasato, Hiroshi Shamoto, Akitake Kanno, Yasuto Itoyama, Teiji Tominaga

    EPILEPSIA　48　(11)　2160-2166　2007/11

    DOI： 10.1111/j.1528-1167.2007.01228.x 　

    ISSN： 0013-9580

    eISSN： 1528-1167

  122. Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy Peer-reviewed

    K. Jin, S. Okabe, K. Chida, N. Abe, T. Kimpara, A. Ohnuma, H. Nomura, Y. Itoyama, H. Onodera

    NEUROLOGY　68　(19)　1618-1621　2007/05

    DOI： 10.1212/01.wnl.0000260975.74618.d7 　

    ISSN： 0028-3878

  123. CSF tau protein: a new prognostic marker for Guillain-Barre syndrome(Reply from the Authors) Peer-reviewed

    Jin K, Takeda A, Shiga Y, Sato S, Ohnuma A, Nomura H, Arai H, Kusunoki S, Ikeda M, Itoyama Y

    Neurology　68　1438-1439　2007

    DOI： 10.1212/01.wnl.0000265410.55320.3f 　

  124. Spade-shaped vocal cord in a multiple system atrophy patient with nocturnal stridor Peer-reviewed

    Kazutaka Jin, Hiroshi Onodera, Keiji Chida, Norio Abe, Yasuto Itoyama

    INTERNAL MEDICINE　46　(12)　921-921　2007

    DOI： 10.2169/internalmedicine.46.0055 　

    ISSN： 0918-2918

  125. CSF tau protein: a new prognostic marker for Guillain-Barré syndrome. International-journal Peer-reviewed

    K Jin, A Takeda, Y Shiga, S Sato, A Ohnuma, H Nomura, H Arai, S Kusunoki, M Ikeda, Y Itoyama

    Neurology　67　(8)　1470-2　2006/10/24

    DOI： 10.1212/01.wnl.0000240119.29939.c7 　

    ISSN： 0028-3878

    eISSN： 1526-632X

  126. MRI findings from a case of fulminating adult-onset measles encephalitis Peer-reviewed

    Kazutaka Jin, Shigeru Sato, Ryuji Saito, Ayumu Ohnuma, Hiroshi Nomura, Yasuto Itoyama

    INTERNAL MEDICINE　45　(12)　783-787　2006

    DOI： 10.2169/internalmedicine.45.1682 　

    ISSN： 0918-2918

  127. Periodic episodes of aphasia as an unusual manifestation of partial status epilepticus Peer-reviewed

    T Hasegawa, Y Shiga, K Narikawa, K Jin, K Fujihara, A Takeda, Y Itoyama

    JOURNAL OF CLINICAL NEUROSCIENCE　12　(7)　820-822　2005/09

    DOI： 10.1016/j.jocn.2004.09.024 　

    ISSN： 0967-5868

  128. Familial leptomeningeal amyloidosis with a transthyretin variant Asp18Gly representing repeated subarachnoid haemorrhages with superficial siderosis Peer-reviewed

    K Jin, S Sato, T Takahashi, H Nakazaki, Y Date, M Nakazato, T Tominaga, Y Itoyama, S Ikeda

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　75　(10)　1463-1466　2004/10

    DOI： 10.1136/jnnp.2003.029942 　

    ISSN： 0022-3050

  129. Clinical features of Creutzfeldt-Jakob disease with V180I mutation Peer-reviewed

    K Jin, Y Shiga, S Shibuya, K Chida, Y Sato, H Konno, K Doh-ura, T Kitamoto, Y Itoyama

    NEUROLOGY　62　(3)　502-505　2004/02

    DOI： 10.1212/01.wnl.0000106954.54011.80 　

    ISSN： 0028-3878

  130. [A case of neuralgic amyotrophy manifesting bilateral anterior interosseous nerve syndrome]. Peer-reviewed

    Naoki Suzuki, Kazutaka Jin, Yusei Shiga, Hiroyuki Kato, Yasuto Itoyama

    No to shinkei = Brain and nerve　54　(7)　605-8　2002/07

    ISSN： 0006-8969

    More details Close

    A 49-year-old woman acutely developed severe bilateral shoulder pain followed by weakness of the right shoulder girdle muscles. Within a few days, an inability to flex the terminal phalanges of the bilateral thumbs and index fingers emerged. Neurologic examination 1 month after the onset of symptoms showed atrophy of the right shoulder girdle muscles and mild decreased cutaneous sensation in the distribution of the right axillary nerve. Needle electromyography examination at this time showed fibrillation potentials in the right deltoid and bilateral flexor pollicus longus muscles. Recruitment of the right deltoid, supra- and infraspinatus muscles was reduced. Motor unit potentials in these muscles were of normal configuration. Nerve conduction studies in the upper limb were normal. She was diagnosed as neuralgic amyotrophy with bilateral anterior interosseous nerve syndrome. 4 months later, the muscles innervated by the bilateral anterior interosseous nerve improved in the muscle strength. Clinical features of this case were compatible with a mononeuropathy multiplex form of neuralgic amyotrophy associated with an autoimmune etiology. We think this case is important for speculating the pathogenesis of neuralgic amyotrophy. This case reminds us that patients with neuralgic amyotrophy sometimes demonstrate anterior interosseous nerve syndrome and most patients manifesting anterior interosseous nerve syndrome are patients with neuralgic amyotrophy.

  131. A case of medial medullary infarction with persistent primitive hypoglossal artery Peer-reviewed

    Kazutaka Jin, Naoto Aihara, Tetsuro Tsukamoto

    Brain and Nerve　54　(4)　341-345　2002

    ISSN： 0006-8969

  132. Transcranial magnetic stimulation alleviates truncal ataxia in spinocerebellar degeneration Peer-reviewed

    Y Shiga, T Tsuda, Y Itoyama, H Shimizu, KI Miyazawa, K Jin, T Yamazaki

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　72　(1)　124-126　2002/01

    DOI： 10.1136/jnnp.72.1.124 　

    ISSN： 0022-3050

  133. Fluoro-DOPA and FDG positron emission tomography in a case of pathologically verified pure diffuse Lewy body disease [4]

    Kinya Hisanaga, Hiroyoshi Suzuki, Hiroaki Tanji, Hiroshi Mochizuki, Yuzo Iwasaki, Noboyuki Sato, Kazutaka Jin

    Journal of Neurology　248　(10)　905-906　2001

    DOI： 10.1007/s004150170079 　

    ISSN： 0340-5354

  134. Diffuse Lewy body disease searched out from 114 patients with parkinsonism Peer-reviewed

    K. Jin, N. Sato, K. Hisanaga, H. Suzuki, H. Mochizuki

    Clinical Neurology　40　(4)　329-333　2000

    ISSN： 0009-918X

Show all ︎Show first 5

Misc. 151

  1. Potential of text-based remote psychological support for patients with epilepsy

    小川舞美, 浮城一司, 藤川真由, 亀井幹子, 小木曽由佳, 古村智, 遠藤英徳, 中里信和, 神一敬

    てんかん研究　43　(2)　2025

    ISSN： 0912-0890

  2. 選択的脳領域麻酔による新規機能マッピング法の確立

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 新妻邦泰, 新妻邦泰, 新妻邦泰, 神一敬, 遠藤英徳

    臨床神経生理学(Web)　53　(5)　2025

    ISSN： 2188-031X

  3. Surgical approach to insulo-opercular epilepsy: insights from functional risk assessment

    大沢伸一郎, 浮城一司, 柿沼一雄, 石田誠, 菊地花, 下田由輝, 神一敬, 植松貢, 鈴木匡子, 遠藤英徳

    てんかん研究　43　(2)　2025

    ISSN： 0912-0890

  4. Selectvie Anesthesia for Functional Evaluation (SAFE) with application of endovascular treatment techniques in epilepsy surgery

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 金森政之, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 神一敬, 遠藤英徳

    てんかん研究　43　(2)　2025

    ISSN： 0912-0890

  5. Diagnostic value of relationship between epileptogenic zone and the frequency change of epileptic spike during selective anesthesia by super-selective infusion of propofol to intracranial artery

    石田誠, 大沢伸一郎, 菊地花, 浮城一司, 神一敬, 鈴木匡子, 遠藤英徳, 中里信和

    日本てんかん外科学会プログラム・抄録集　48th　2025

  6. Clinical presentation of new-onset psychogenic nonepileptic seizures after epilepsy surgery

    小川舞美, 大沢伸一郎, 岩城弘隆, 秋月祐子, 藤川真由, 浮城一司, 下田由輝, 神一敬, 富田博秋, 遠藤英徳, 中里信和

    日本てんかん外科学会プログラム・抄録集　48th　2025

  7. てんかんのポリジェニックリスクスコアとてんかん発症との関連:系統的レビューとメタ解析

    久保田隆文, 久保田隆文, NGADIMON Irma Wati, VISWANATHAN Sindhu, 大瀬戸恒志, RAVAT Parthvi, ACHARYA Mrinal Kumar, 黒田直生人, 黒田直生人, 此松和俊, 此松和俊, 小原拓, 神一敬, 青木正志, 中里信和, DANG Yew Li, DANG Yew Li

    てんかん研究　42　(3)　2025

    ISSN： 0912-0890

  8. Diagnostic method for localizing function by Neuro-logical Evaluation Under Regional Anesthesia (NEURA-NET)

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝頼一登, 浮城一司, 金森政之, 下田由輝, 新妻邦泰, 新妻邦泰, 松本康史, 神一敬, 中里信和, 遠藤英徳

    てんかん研究　42　(3)　2025

    ISSN： 0912-0890

  9. 超選択的Wadaテストによって言語優位半球と言語性記憶の優位半球が異なることが明らかになった内側側頭葉てんかんの1症例

    菊地花, 大沢伸一郎, 柿沼一雄, 太田祥子, 勝瀬一登, 勝瀬一登, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

    てんかん研究　42　(3)　2025

    ISSN： 0912-0890

  10. 10-10電極配置法に則った追加脳波電極が発作時脳波変化の検出に有用であった一例

    坂本美佳, 神一敬, 此松和俊, 此松和俊, 大沢伸一郎, 浮城一司, 浅黄優, 三木俊, 中里信和

    全国てんかんセンター協議会総会プログラム・抄録集　12th　2025

  11. 左右側頭葉てんかんにおけるセルフスティグマの関連要因の差異

    小川舞美, 藤川真由, 浮城一司, 此松和俊, 此松和俊, 久保田隆文, 久保田隆文, 大友風佳, 高橋健人, 柿坂庸介, 神一敬, 中里信和

    全国てんかんセンター協議会総会プログラム・抄録集　12th　2025

  12. Density spectral array may differentiate between frontal lobe epilepsy and non-rapid eye movement sleep parasominias with deep learning techniques

    此松和俊, 此松和俊, 柏田祐樹, 神一敬, 久保田隆文, 久保田隆文, 浮城一司, 柿坂庸介, 青木正志, 中里信和

    日本臨床睡眠医学会学術集会プログラム・抄録集(Web)　15th　2024

  13. A patient with left frontal lobe epilepsy showing arousals associated with interictal epileptiform discharges

    高野歩有, 宇根岡紗希, 植松貢, 浮城一司, 神一敬, 中里信和

    日本臨床睡眠医学会学術集会プログラム・抄録集(Web)　15th　2024

  14. Three patients with focal epilepsy having interictal epileptiform discharges only during deep sleep

    板橋泉, 浅黄優, 伊澤理香子, 神一敬, 三木俊, 中里信和, 中里信和

    日本臨床睡眠医学会学術集会プログラム・抄録集(Web)　15th　2024

  15. てんかん焦点切除後に書字への関心が顕著となった自閉症スペクトラムの一例

    柿沼一雄, 大沢伸一郎, 曽我天馬, 浮城一司, 神一敬, 勝瀬一登, 勝瀬一登, 森田亜由美, 遠藤佳子, 遠藤英徳, 中里信和, 鈴木匡子

    日本神経精神医学会学術集会プログラム・抄録集　29th (CD-ROM)　2024

  16. 体性感覚誘発磁界による下肢一次体性感覚野の前頭葉局在の検証

    石田誠, 片山遥, 神一敬, 柿坂庸介, 中里信和, 中里信和

    臨床神経生理学(Web)　52　(5)　2024

    ISSN： 2188-031X

  17. Estimation of different functional aspects of language for specific brain regions using the super-selective Wada test

    柿沼一雄, 大沢伸一郎, 勝瀬一登, 勝瀬一登, 菊地花, 太田祥子, 川村藍, 劉軍艶, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

    てんかん研究　42　(2)　2024

    ISSN： 0912-0890

  18. Memory scores in the Wada test can be decreased by drug distribution into the language function area

    菊地花, 大沢伸一郎, 柿沼一雄, 勝瀬一登, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

    てんかん研究　42　(2)　2024

    ISSN： 0912-0890

  19. 麻酔薬の頭蓋内選択的動注と認知神経学的評価を融合した任意脳領域の機能局在診断法

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝瀬一登, 浮城一司, 金森政之, 下田由輝, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 神一敬, 中里信和, 遠藤英徳

    日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024

    ISSN： 2759-6907

  20. 左側頭葉新皮質病変を伴うてんかんにおける発作時心拍上昇率の比較

    高野歩有, 浮城一司, 曽我天馬, 神一敬, 板橋泉, 大沢伸一郎, 大沢伸一郎, 岩崎真樹, 遠藤英徳, 中里信和

    臨床神経生理学(Web)　52　(5)　2024

    ISSN： 2188-031X

  21. 焦点および全般てんかんではどの睡眠段階で発作間欠時てんかん放電がみられるか?

    板橋泉, 浅黄優, 神一敬, 浮城一司, 三木俊, 中里信和, 中里信和

    臨床神経生理学(Web)　52　(5)　2024

    ISSN： 2188-031X

  22. 海馬硬化を伴う内側側頭葉てんかん患者における側頭葉深部の脳磁図棘波信号源の臨床的意義

    大村 花薫子, 石田 誠, 柿坂 庸介, 神 一敬, 大沢 伸一郎, 中里 信和

    日本生体磁気学会誌　37　(1)　140-141　2024

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  23. Interprofessional work in epilepsy monitoring unit: a talk from EEG technologist’s viewpoint

    板橋泉, 浅黄優, 神一敬, 三木俊, 中里信和

    日本臨床睡眠医学会学術集会プログラム・抄録集(Web)　14th　2023

  24. 扁桃体肥大を伴う側頭葉てんかん患者における発作間欠期の神経磁場スパイクのECD配向(ECD direction of interictal neuromagnetic spikes in patients with temporal lobe epilepsy with amygdala enlargement)

    Konomatsu Kazutoshi, Jin Kazutaka, Ishida Makoto, Sato Shiho, Morishita Yohei, Soga Temma, Ukishiro Kazushi, Kakisaka Yosuke, Kanno Akitake, Mugikura Shunji, Aoki Masashi, Nakasato Nobukazu

    日本生体磁気学会誌　36　(1)　158-159　2023

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  25. 側頭葉てんかん患者において深部に推定される発作間欠時棘波信号源の臨床的意義

    石田 誠, 大村 花薫子, 神 一敬, 菅野 彰剛, 大沢 伸一郎, 柿坂 庸介, 安藤 康夫, 中里 信和

    日本生体磁気学会誌　36　(1)　160-161　2023

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  26. 【てんかん診療update-診断,治療,社会整備,基礎研究の最新情報-】てんかんの診断 てんかんの病因

    此松 和俊, 神 一敬

    日本臨床　80　(12)　1921-1924　2022/12

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  27. A proposal report about clinical electroencephalography in Japan from the EEG subcommittee

    Japanese Journal of Clinical Neurophysiology　50　(3)　107-112　2022/06

    Publisher: Japanese Society of Clinical Neurophysiology

    DOI： 10.11422/jscn.50.107 　

    ISSN： 1345-7101

    eISSN： 2188-031X

  28. 生体磁気計測関係のアーチファクト てんかん患者の脳磁図計測・解析におけるアーチファクト

    石田 誠, 神 一敬, 菅野 彰剛, 柿坂 庸介, 中里 信和

    日本生体磁気学会誌　35　(1)　50-51　2022

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  29. 若年ミオクロニーてんかんにおける体性感覚誘発磁界の異常

    片山 遥, 石田 誠, 菅野 彰剛, 神 一敬, 中里 信和

    日本生体磁気学会誌　35　(1)　118-119　2022

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  30. 扁桃体腫大を伴う側頭葉てんかん患者における脳磁図所見の特徴

    此松 和俊, 神 一敬, 石田 誠, 佐藤 志帆, 森下 陽平, 曽我 天馬, 柿坂 庸介, 菅野 彰剛, 麦倉 俊司, 青木 正志, 中里 信和

    日本生体磁気学会誌　35　(1)　120-121　2022

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  31. 開頭術後に生じた心因性非てんかん発作に心理社会的アプローチが著効した1例 Peer-reviewed

    小川 舞美, 大沢 伸一郎, 上利 大, 柿坂 庸介, 神 一敬, 冨永 悌二, 中里 信和

    脳神経外科速報　31　(6)　e1-e11　2021/11

    Publisher: (株)メディカ出版

    ISSN： 0917-1495

  32. 睡眠とてんかん-最新の話題をめぐって-6.ノンレム睡眠に着目した前頭葉てんかんの特徴

    神一敬, 神一敬, 板橋泉, 中村美輝, 中里信和, 中里信和

    睡眠医療　15　(2)　2021

    ISSN： 1882-2096

  33. オンライン教育のプレゼンテーションにおける残像効果のある「指マーカー機能」の有用性

    柿坂 庸介, 神 一敬, 大沢 伸一郎, 中里 信和

    日本遠隔医療学会雑誌　16　(2)　145-147　2020/12

    Publisher: (一社)日本遠隔医療学会

    ISSN： 1880-800X

  34. てんかん診療における遠隔外来と包括的入院精査の相補的利用 Peer-reviewed

    柿坂 庸介, 大沢 伸一郎, 成田 徳雄, 神 一敬, 冨永 悌二, 中里 信和

    脳神経外科速報　30　(11)　1254-1261　2020/11

    Publisher: (株)メディカ出版

    ISSN： 0917-1495

    More details Close

    てんかんに対する遠隔外来と包括的入院精査の相補的利用の有用性について検討した。テレビ会議システムによる遠隔てんかん外来を初診した患者32名(男性24例、女性8例、13〜75歳)を対象とした。32例中23例において遠隔てんかん外来で診断精度が向上し、具体的にはてんかんか否かの診断の確定が9例、てんかんという診断で焦点性か全般性かが鑑別できたものが9例、焦点てんかんでさらなる部位診断が確定したのが5例であった。遠隔てんかん外来で診断精度が向上した23例中5例で包括的精査入院が行われ、3例でさらに診断精度が向上した。遠隔てんかん外来で診断精度が向上しなかった9例中5例で包括的精査入院が行われ、遠隔てんかん外来の診断が包括的精査入院で変更された。遠隔てんかん外来で診断精度が向上しており、有用性があらためて確認された。

  35. よく使う日常治療薬の正しい使い方 抗てんかん薬の正しい使い方

    上利 大, 神 一敬

    レジデントノート　22　(9)　1747-1750　2020/09

    Publisher: (株)羊土社

    ISSN： 1344-6746

  36. 【きちっとおさえる けいれん・てんかんと看護】けいれん発作・てんかん発作とは

    上利 大, 神 一敬

    Brain Nursing　36　(8)　760-764　2020/08

    Publisher: (株)メディカ出版

    ISSN： 0910-8459

  37. 【精神科診療のエビデンス-国内外の重要ガイドライン解説】(第13章)てんかん てんかん診療ガイドライン2018

    神 一敬

    精神医学　62　(5)　720-725　2020/05

    Publisher: (株)医学書院

    ISSN： 0488-1281

    eISSN： 1882-126X

  38. 各種疾患 機能性疾患 てんかん診療ガイドライン2018 改訂ポイントと最近の動向

    神 一敬

    Annual Review神経　2020　333-340　2020/04

    Publisher: (株)中外医学社

  39. Seizures during sleep in adult patients with epilepsy

    Jin Kazutaka, Itabashi Izumi, Nakamura Miki, Nakasato Nobukazu

    Japanese Journal of Clinical Neurophysiology　48　(1)　40-44　2020/02

    Publisher: Japanese Society of Clinical Neurophysiology

    DOI： 10.11422/jscn.48.40 　

    ISSN： 1345-7101

    eISSN： 2188-031X

  40. てんかんの地域診療連携体制推進のためのてんかん診療拠点病院運用ガイドラインに関する研究 拠点病院調査(遠隔医療を中心に)

    中里信和, 神一敬, 柿坂庸介, 菅野彰剛, 上利大

    てんかんの地域診療連携体制の推進のためのてんかん診療拠点病院運用ガイドラインに関する研究 令和元年度 総括・分担研究報告書(Web)　2020

  41. MEGによるてんかん研究 up-to-date 覚醒時の体性感覚誘発磁界第1波の信号強度抑制は側頭葉てんかんの罹病期間と相関する

    石田 誠, 神 一敬, 柿坂 庸介, 菅野 彰剛, 川島 隆太, 中里 信和

    日本生体磁気学会誌　33　(1)　62-63　2020

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  42. 下唇刺激体性感覚誘発磁界が焦点切除術前評価に有用であった頭頂弁蓋部てんかんの一例

    菅野 彰剛, 神 一敬, 柿坂 庸介, 上利 大, 浮城 一司, 土屋 真理夫, 石田 誠, 大沢 伸一郎, 冨永 悌二, 中里 信和

    日本生体磁気学会誌　33　(1)　108-110　2020

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

    More details Close

    症例は27歳男性で、12歳時より動作停止と意識減損を主体とする発作が月単位で出現するようになり、てんかんとの臨床診断でカルバマゼピンが開始された。しかし、発作は抑制されず、25歳より発作症状頻度も日単位に増加した。今回、左口腔内に違和感を自覚したのちに左頬部のびくつきが出現し、同時に左口角からの流涎が著明となり、意識減損に至った。正中神経刺激体性感覚誘発磁界記録では左刺激N20mを頂点潜時19.5ms、右刺激で20.0msに記録し、左右差を認めなかった。一方、下口唇刺激体性感覚誘発磁界では左刺激で頂点潜時23.5ms、57.5ms、右刺激では18.5ms、56.5msであり、軽度ながら左刺激右患側半球反応の異常な潜時延長を認めた。頭蓋内電極留置によるEEG記録および機能マッピングを経て発作起始が顔面、口腔領域の感覚運動領域であることを確認した。同部の切除術を行ったところ、術後に発作は消失し、機能麻痺も残存しなかった。

  43. 脳磁図により島回と帯状回の関与が推測された笑い発作を伴う左前頭葉てんかんの一例

    上利 大, 柿坂 庸介, 菅野 彰剛, 石田 誠, 曽我 天馬, 神 一敬, 中里 信和

    日本生体磁気学会誌　33　(1)　117-119　2020

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  44. Tele-epilepsy conference : How we can maximize an educational effect of teleconference system

    柿坂 庸介, 神 一敬, 上利 大, 土屋 真理夫, 浮城 一司, 大沢 伸一郎, 中里 信和

    日本遠隔医療学会雑誌　15　(2)　127-129　2019/09

    Publisher: (一社)日本遠隔医療学会

    ISSN： 1880-800X

  45. 【てんかん:診断と治療の現在】てんかん発作症候とその鑑別

    神 一敬

    医学のあゆみ　270　(6-7)　525-528　2019/08

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  46. 結節性硬化症 疾患の正しい理解と適切な診療連携・移行医療(トランジション)を目指して Peer-reviewed

    池田 昭夫, 赤松 直樹, 神 一敬, 岡 明, 高橋 孝雄

    脳神経内科　91　(2)　270-277　2019/08

    Publisher: (有)科学評論社

    ISSN： 2434-3285

    More details Close

    結節性硬化症(TSC)では患者の生涯にわたって全身症状の長期経過観察が必要であるため、多くの診療科に所属する医療従事者間での診療連携と小児期から成人期への移行医療が極めて重要である。また、患者の重症度によって診療方針が大きく異なるため、個々の患者に応じた医療の実践が必要である。1)TSCの発症機序と疫学・診断・症状、2)TSCという疾患の正しい理解の必要性、3)TSCにおける適切な診療連携・移行医療のあり方、について概説した。

  47. 【小児てんかんの発作時脳波記録における課題と工夫】小児の長時間ビデオ脳波モニタリング 臨床検査技師の立場から

    浅黄 優, 神 一敬, 植松 貢, 三木 俊, 中里 信和

    臨床神経生理学　47　(2)　99-104　2019/04

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

  48. 【高齢者のその症状てんかんではありませんか?】てんかんとともに生きる高齢者の悩みと活用できる社会資源

    小川 舞美, 本庄谷 奈央, 藤川 真由, 神 一敬, 中里 信和

    コミュニティケア　21　(2)　24-27　2019/02

    Publisher: (株)日本看護協会出版会

  49. 【見逃してはいけない!間違いやすい抗てんかん薬処方】そもそもてんかんではなかった! 起立性低血圧による失神に対する抗てんかん薬の処方

    北澤 悠, 神 一敬, 田中 章景, 中里 信和

    薬事　61　(1)　25-27　2019/01

    Publisher: (株)じほう

    ISSN： 0016-5980

  50. 【見逃してはいけない!間違いやすい抗てんかん薬処方】妊娠可能年齢の女性に対する抗てんかん薬 バルプロ酸の大量投与

    上利 大, 神 一敬, 中里 信和

    薬事　61　(1)　29-32　2019/01

    Publisher: (株)じほう

    ISSN： 0016-5980

  51. てんかん脳磁図の"ベスト・オブ・ザ・ベスト" 東北大学病院の「てんかん脳磁図ベスト・オブ・ザ・ベスト」

    神 一敬, 柿坂 庸介, 石田 誠, 菅野 彰剛, 岩崎 真樹, 川島 隆太, 中里 信和

    日本生体磁気学会誌　32　(1)　62-63　2019

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  52. 脳磁図棘波の信号源推定に平均加算と空間フィルター法の併用が役立った前頭葉てんかんの1症例

    菅野 彰剛, 神 一敬, 大沢 伸一郎, 石田 誠, 柿坂 庸介, 上利 大, 浮城 一司, 土屋 真理夫, 中里 信和

    日本生体磁気学会誌　32　(1)　114-115　2019

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  53. 側頭葉てんかん患者の体性感覚誘発磁界の信号強度は覚醒時のみ抑制される

    石田 誠, 神 一敬, 柿坂 庸介, 菅野 彰剛, 川島 隆太, 中里 信和

    日本生体磁気学会誌　32　(1)　150-151　2019

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  54. 下肢の体性感覚誘発磁界の異常が局在診断に寄与した焦点てんかんの1例

    上利 大, 神 一敬, 柿坂 庸介, 菅野 彰剛, 石田 誠, 中里 信和

    日本生体磁気学会誌　32　(1)　194-195　2019

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  55. 【てんかん学と臨床神経生理学との接点-その最新知見と臨床応用-】 焦点発作の側方診断と自律神経

    神 一敬, 加藤 量広, 鈴木 菜摘, 中里 信和

    臨床神経生理学　46　(6)　585-590　2018/12

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

  56. 【じっくりじんわり神経診察-実臨床での胆力をつけるために】疾患に応じた神経診察 てんかん

    神 一敬

    内科　122　(6)　1157-1160　2018/12

    Publisher: (株)南江堂

    ISSN： 0022-1961

  57. レセプトデータベースに基づく妊娠前、妊娠中、および出産後の抗てんかん薬処方状況の評価

    石川 智史, 小原 拓, 神 一敬, 西郡 秀和, 都田 桂子, 鈴鹿 雅人, 赤沢 学, 中里 信和, 八重樫 伸生, 栗山 進一, 眞野 成康

    日本薬剤疫学会学術総会抄録集　24回　98-98　2018/10

    Publisher: (一社)日本薬剤疫学会

  58. 【てんかんをめぐる最近の話題:小児から高齢者まで】てんかん診療における情報通信技術

    柿坂 庸介, 神 一敬, 中里 信和

    BIO Clinica　33　(11)　1032-1036　2018/10

    Publisher: (株)北隆館

    ISSN： 0919-8237

  59. 過運動発作を呈した前頭葉てんかんに対する外科治療 Peer-reviewed

    大沢 伸一郎, 岩崎 真樹, 高山 裕太郎, 神 一敬, 中里 信和, 冨永 悌二

    脳神経外科ジャーナル　27　(10)　764-772　2018/10

    Publisher: 日本脳神経外科コングレス

    ISSN： 0917-950X

  60. 若年ミオクロニーてんかんの多剤併用療法における薬剤選択

    北澤悠, 神一敬, 柿坂庸介, 藤川真由, 中里信和, 田中章景

    てんかん研究　36　(2)　570-570　2018/09/12

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

  61. 脳磁図の再評価とさらなる発展を目指して 電流双極子のみによらないてんかん波形の解釈 脳磁図とステレオ脳波の同時記録による棘波の検出

    神 一敬, 柿坂 庸介, 中里 信和

    日本生体磁気学会誌　31　(1)　80-81　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  62. 【てんかん診療-すべての医師のための診断・治療のコツ-】 てんかんの検査・診断 高齢者てんかんと認知症

    上利 大, 神 一敬, 中里 信和

    日本臨床　76　(6)　926-931　2018/06

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  63. 【てんかん診療-すべての医師のための診断・治療のコツ-】 てんかんの検査・診断 遠隔てんかん症例検討会

    柿坂 庸介, 上利 大, 大沢 伸一郎, 神 一敬, 中里 信和

    日本臨床　76　(6)　932-936　2018/06

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  64. 脳磁図の再評価とさらなる発展を目指して 電流双極子のみによらないてんかん波形の解釈 脳磁図とステレオ脳波の同時記録による棘波の検出

    神 一敬, 柿坂 庸介, 中里 信和

    日本生体磁気学会誌　31　(1)　80-81　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  65. 聴覚性前兆を呈した側頭葉てんかん患者における脳波・脳磁図による発作間欠時棘波の信号源推定

    上利 大, 神 一敬, 柿坂 庸介, 菅野 彰剛, 石田 誠, 中里 信和

    日本生体磁気学会誌　31　(1)　104-105　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  66. 【てんかん診療-すべての医師のための診断・治療のコツ-】 てんかんの検査・診断 長時間ビデオ脳波モニタリング検査

    神 一敬

    日本臨床　76　(6)　895-900　2018/06

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  67. 【てんかん診療-すべての医師のための診断・治療のコツ-】 てんかんの最新治療 自己免疫性てんかん

    神 一敬

    日本臨床　76　(6)　1002-1007　2018/06

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  68. 【けいれん、意識障害を考える】明日から使えるけいれん、意識障害の診断と治療 二次性全般化発作と強直間代発作の鑑別と治療

    神 一敬

    クリニシアン　65　(5-6)　442-446　2018/06

    Publisher: エーザイ(株)

    ISSN： 0387-1541

  69. 脳磁図の再評価とさらなる発展を目指して 電流双極子によるてんかん波形の解釈 てんかん診断における「電流双極子モデル」の長所と短所

    中里 信和, 菅野 彰剛, 石田 誠, 上利 大, 大沢 伸一郎, 柿坂 庸介, 神 一敬

    日本生体磁気学会誌　31　(1)　40-41　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  70. 脳磁図の再評価とさらなる発展を目指して 電流双極子によるてんかん波形の解釈 てんかん診療における脳磁図の役割と電流双極子モデルの意味

    柿坂 庸介, 神 一敬, 北澤 悠, 上利 大, 高山 裕太郎, 大沢 伸一郎, 菅野 彰剛, 中里 信和

    日本生体磁気学会誌　31　(1)　42-43　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  71. てんかん切除術後に主成分分析による脳磁図追加解析が残存発作を説明できた2例

    菅野 彰剛, 神 一敬, 石田 誠, 柿坂 庸介, 上利 大, 大沢 伸一郎, 岩崎 真樹, 中里 信和

    日本生体磁気学会誌　31　(1)　100-101　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  72. 脳磁図は体性感覚誘発性棘波様活動を成人でも観察できる

    石田 誠, 菅野 彰剛, 柿坂 庸介, 神 一敬, 上利 大, 川島 隆太, 中里 信和

    日本生体磁気学会誌　31　(1)　102-103　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  73. てんかんモニタリングユニット(EMU)を支えるコメディカルの役割 頭蓋内長時間脳波記録・判読における臨床検査技師の役割

    櫻庭 理絵, 大沢 伸一郎, 神 一敬

    Epilepsy: てんかんの総合学術誌　12　(1)　39-41　2018/05

    Publisher: (株)メディカルレビュー社

    ISSN： 1882-1480

  74. 【国民病としての不眠症治療】 睡眠障害に併存する疾患 睡眠障害とてんかん

    神 一敬

    クリニシアン　65　(4)　344-349　2018/04

    Publisher: エーザイ(株)

    ISSN： 0387-1541

  75. 【日常診療で増えてきた高齢者のてんかん】 高齢者における抗てんかん薬選択のポイント

    神 一敬

    Geriatric Medicine　56　(3)　237-240　2018/03

    Publisher: (株)ライフ・サイエンス

    ISSN： 0387-1088

  76. 【-デキる内科医の-神経内科コンサルト】救急外来,急性期入院病棟からのコンサルト てんかん発作

    神 一敬

    Medicina　55　(2)　226-228　2018/02

    Publisher: (株)医学書院

    ISSN： 0025-7699

  77. 【実施診療のための最新認知症学-検査・治療・予防・支援-】 鑑別診断 高齢者てんかんの診断と治療

    上利 大, 神 一敬, 中里 信和

    日本臨床　76　(増刊1 実施診療のための最新認知症学 検査・治療・予防・支援)　148-152　2018/01

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  78. 医療トレンド 成人てんかんの診断と薬物治療

    上利 大, 神 一敬, 中里 信和

    Schneller　(108)　7-12　2018

    Publisher: (株)ファルコバイオシステムズ

  79. 【もう慌てないけいれん・てんかん 発作時の対応・治療・日常生活支援までバッチリわかる!】 てんかんの薬物治療と看護 頻用される旧来薬

    神 一敬

    Brain Nursing　33　(12)　1164-1169　2017/12

    Publisher: (株)メディカ出版

    ISSN： 0910-8459

  80. [A surgical case of mesial temporal lobe epilepsy associated with hippocampal sclerosis and traumatic neocortical lesion].

    Yu Kitazawa, Kazutaka Jin, Masaki Iwasaki, Hiroyoshi Suzuki, Fumiaki Tanaka, Nobukazu Nakasato

    Rinsho shinkeigaku = Clinical neurology　57　(11)　698-704　2017/11/25

    Publisher: (一社)日本神経学会

    DOI： 10.5692/clinicalneurol.cn-001029 　

    ISSN： 0009-918X

    More details Close

    A 26-year-old right-handed woman, with a history of left temporal lobe contusion caused by a fall at the age of 9 months, started to have complex partial seizures with oral automatism at the age of 7 years. The seizures occurred once or twice a month despite combination therapy with several antiepileptic agents. Her history and imaging studies suggested the diagnosis of epilepsy arising from traumatic neocortical temporal lesion. Comprehensive assessment including long-term video EEG monitoring, MRI, FDG-PET, MEG, and neuropsychological evaluation was performed at the age of 26 years. The diagnosis was left mesial temporal lobe epilepsy associated with hippocampal atrophy and traumatic temporal cortical lesion. The patient was readmitted for surgical treatment at the age of 27 years. Intracranial EEG monitoring showed that ictal discharges started in the left hippocampus and spread to the traumatic lesion in the left posterior superior temporal gyrus 10 seconds after the onset. This case could not be classified as dual pathology exactly, because the traumatic left temporal cortical lesion did not show independent epileptogenicity. However, the traumatic lesion was highly likely to be the source of the epileptogenicity, and she had right hemispheric dominance for language and functional deterioration in the whole temporal cortex. Therefore, left amygdalo-hippocampectomy and left temporal lobectomy including the traumatic lesion were performed according to the diagnosis of dual pathology. Subsequently, she remained seizure-free for 3 years. Comprehensive assessment of seizure semiology, neurophysiology, neuroradiology, and neuropsychology is important to determine the optimum therapeutic strategies for drug-resistant epilepsy.

  81. 【事例から学ぶ(その2)】 てんかん患者の就労支援における医療の役割

    藤川 真由, 岩城 弘隆, 大竹 茜, 柿坂 庸介, 北澤 悠, 神 一敬, 中里 信和

    職業リハビリテーション　31　(1)　3-9　2017/09

    Publisher: 日本職業リハビリテーション学会

    ISSN： 0915-0870

  82. 【てんかん-New guideline compact】 てんかんの検査 ビデオ脳波の意義

    北澤 悠, 神 一敬

    Clinical Neuroscience　35　(7)　819-821　2017/07

    Publisher: (株)中外医学社

    ISSN： 0289-0585

  83. 【神経内科 診断推論】 主訴で神経内科診断を推論する けいれん

    神 一敬

    Modern Physician　37　(7)　673-676　2017/07

    Publisher: (株)新興医学出版社

    ISSN： 0913-7963

  84. 【一般臨床医に必要なてんかんの基礎知識とトピックス】 てんかん診療の実際 新しい抗てんかん薬の特徴 ペランパネル・ラコサミド・オクスカルバゼピン

    神 一敬

    診断と治療　105　(7)　873-875　2017/07

    Publisher: (株)診断と治療社

    ISSN： 0370-999X

  85. てんかん患者の予期せぬ突然死

    神 一敬

    クリニシアン　64　(5-6)　505-510　2017/06

    Publisher: エーザイ(株)

    ISSN： 0387-1541

  86. てんかん診療における多職種の人材育成 脳波技師の育成

    神 一敬, 中里 信和

    Epilepsy: てんかんの総合学術誌　11　(1)　37-38　2017/05

    Publisher: (株)メディカルレビュー社

    ISSN： 1882-1480

  87. 【「見せかけの難治てんかん」への挑戦】 長時間ビデオ脳波モニタリング検査

    神 一敬

    日本医事新報　(4853)　22-27　2017/04

    Publisher: (株)日本医事新報社

    ISSN： 0385-9215

  88. 【神経内科がわかる、好きになる 今日から実践できる診察・診断・治療のエッセンス】 (第5章)神経内科の重要疾患 エキスパートはこう診断する! てんかん

    北澤 悠, 神 一敬, 中里 信和

    レジデントノート　18　(17)　3153-3157　2017/02

    Publisher: (株)羊土社

    ISSN： 1344-6746

  89. Comparison of MEG findings between patients with dysembryoplastic neuroepithelial tumor and ganglioglioma

    TAKAYAMA Yutaro, JIN Kazutaka, KAKISAKA Yosuke, KITAZAWA Yu, AGARI Dai, KANNO Akitake, KANNO Akitake, ISHIDA Makoto, NAKASATO Nobukazu, NAKASATO Nobukazu

    日本生体磁気学会誌　30　(1)　2017

    ISSN： 0915-0374

  90. A case of subclinical seizures uniquely detected by magnetoencephalography

    ISHIDA Makoto, KANNO Akitake, KANNO Akitake, KAKISAKA Yosuke, IWASAKI Masaki, JIN Kazutaka, KITAZAWA Yu, KAWASHIMA Ryuta, NAKASATO Nobukazu, NAKASATO Nobukazu

    日本生体磁気学会誌　30　(1)　2017

    ISSN： 0915-0374

  91. 多小脳回患者で認められた正中神経刺激体性感覚誘発反応における異常ダイポール回転現象

    北澤 悠, 菅野 彰剛, 神 一敬, 石田 誠, 柿坂 庸介, 田中 章景, 中里 信和

    日本生体磁気学会誌　30　(1)　122-123　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  92. 神経内科の重要疾患〜エキスパートはこう診断する! てんかん.

    北澤悠, 神一敬, 中里信和

    増刊レジデントノート 神経内科がわかる，好きになる　8　177-181　2017

  93. 多小脳回患者で認められた正中神経刺激体性感覚誘発反応における異常ダイポール回転現象

    北澤 悠, 菅野 彰剛, 神 一敬, 石田 誠, 柿坂 庸介, 田中 章景, 中里 信和

    日本生体磁気学会誌　30　(1)　122-123　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  94. てんかんの薬物治療管理up to date 抗てんかん薬の副作用と安全性 合理的な薬物治療を目指して

    北澤 悠, 神 一敬, 中里 信和

    日本病院薬剤師会雑誌　52　(10)　1282-1286　2016/10

    Publisher: (一社)日本病院薬剤師会

    ISSN： 1341-8815

  95. てんかんの薬物治療管理up to date 抗てんかん薬の選択 実際の薬物選択と漸増法

    北澤 悠, 神 一敬, 中里 信和

    日本病院薬剤師会雑誌　52　(9)　1113-1116　2016/09

    Publisher: (一社)日本病院薬剤師会

    ISSN： 1341-8815

  96. Efficacy and safety of lacosamide

    神 一敬, 中里 信和

    臨床精神薬理　19　(8)　1189-1195　2016/08

    Publisher: (株)星和書店

    ISSN： 1343-3474

  97. てんかんの薬物治療管理up to date 抗てんかん薬の歴史 従来薬vs.新規抗てんかん薬

    北澤 悠, 神 一敬, 中里 信和

    日本病院薬剤師会雑誌　52　(8)　1004-1007　2016/08

    Publisher: (一社)日本病院薬剤師会

    ISSN： 1341-8815

  98. 【臨床神経生理で何がわかる?[2]脳波・誘発電位・眼球運動】 脳波 てんかんと脳波

    神 一敬

    Clinical Neuroscience　34　(7)　751-755　2016/07

    Publisher: (株)中外医学社

    ISSN： 0289-0585

  99. てんかん脳磁図の最前線 脳磁図はさまざまな領域の棘波を捉える

    柿坂 庸介, 岩崎 真樹, 神 一敬, 北澤 悠, 菅野 彰剛, 中里 信和

    日本生体磁気学会誌　29　(1)　14-15　2016/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  100. 側頭葉てんかん患者における術前MEG言語機能マッピング

    石田 誠, 岩崎 真樹, 菅野 彰剛, 神 一敬, 柿坂 庸介, 川島 隆太, 中里 信和

    日本生体磁気学会誌　29　(1)　128-129　2016/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  101. てんかんとパラソムニア

    松浦 雅人, 福水 道郎, 神 一敬, 田村 義之

    Epilepsy: てんかんの総合学術誌　10　(1)　8-17　2016/05

    Publisher: (株)メディカルレビュー社

    ISSN： 1882-1480

  102. MRIで病巣を確認できない側頭葉てんかんの外科治療

    岩崎真樹, 岩崎真樹, 神一敬, 西尾慶之, 柿坂庸介, 大沢伸一郎, 下田由輝, 中里信和, 冨永悌二

    てんかん研究　34　(2)　2016

    ISSN： 0912-0890

  103. 【これだけは知っておきたい!妊娠・授乳と薬物療法の最新知識】 治療の考え方と薬の選び方・使い方 てんかん 妊娠可能年齢の女性に対する治療

    北澤 悠, 神 一敬, 中里 信和

    薬事　57　(13)　2121-2125　2015/12

    Publisher: (株)じほう

    ISSN： 0016-5980

  104. Sudden unexpected death in epilepsy(SUDEP)

    神 一敬

    Epilepsy: てんかんの総合学術誌　9　(2)　103-107　2015/11

    Publisher: (株)メディカルレビュー社

    ISSN： 1882-1480

  105. 成人てんかんの最新治療戦略

    神 一敬

    BRAIN and NERVE: 神経研究の進歩　67　(8)　1043-1049　2015/08

    Publisher: (株)医学書院

    ISSN： 1881-6096

  106. 不快な感覚・尿意切迫感を自覚する単純部分発作を呈した前帯状回てんかんの1例

    吉野 彰兼, 柿坂 庸介, 神 一敬, 加藤 量広, 佐藤 志帆, 藤川 真由, 北澤 悠, 岩崎 真樹, 板橋 尚, 中里 信和

    小児科臨床　68　(6)　1225-1230　2015/06

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  107. 体性感覚誘発性棘波様活動を脳磁図で検出した成人てんかん3例

    石田 誠, 柿坂 庸介, 菅野 彰剛, 岩崎 真樹, 神 一敬, 川島 隆太, 中里 信和

    日本生体磁気学会誌　28　(1)　154-155　2015/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  108. Premium Edition 症例に学ぶ 医師が処方を決めるまで 成人のてんかん

    神 一敬

    日経ドラッグインフォメーションpremium　(208)　PE17-20　2015/02

    Publisher: 日経BP社

    More details Close

    てんかんは大脳神経細胞の過剰な興奮により反復性の発作を生じる慢性の脳疾患である。有病率は約1％弱と頻度の高い疾患で、国内の患者数は約100万人といわれている。本稿では、てんかんの中でも、成人の局在関連てんかん（部分てんかん）の治療について、当…

  109. 【必携!糖尿病患者の意識障害】 知っておきたい知識の補強 てんかんの意識障害

    加藤 量広, 神 一敬, 中里 信和

    糖尿病診療マスター　13　(2)　148-151　2015/02

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1415200082 　

    ISSN： 1347-8176

  110. 複数の発作周辺期精神症状を含む多彩な発作症状を呈した部分てんかんの1例

    江面 道典, 柿坂 庸介, 神 一敬, 加藤 量広, 岩崎 真樹, 藤川 真由, 青木 正志, 中里 信和

    BRAIN and NERVE: 神経研究の進歩　67　(1)　105-109　2015/01

    Publisher: (株)医学書院

    ISSN： 1881-6096

    eISSN： 1344-8129

  111. [Clinical characteristics of four patients with temporal lobe epilepsy associated with elevated anti-GAD antibodies].

    Tetsuya Akaishi, Kazutaka Jin, Kazuhiro Kato, Hisashi Itabashi, Tatsuro Misu, Maki Tateyama, Masaki Iwasaki, Masashi Aoki, Nobukazu Nakasato

    Rinsho shinkeigaku = Clinical neurology　55　(11)　804-9　2015

    Publisher: (一社)日本神経学会

    DOI： 10.5692/clinicalneurol.cn-000740 　

    ISSN： 0009-918X

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    Anti-glutamic acid decarboxylase (GAD) antibodies are known to be associated with insulin-dependent diabetes mellitus (IDDM), stiff-person syndrome, and other neurological symptoms including temporal lobe epilepsy (TLE), known as autoimmune epilepsy. We treated four patients with TLE who had elevated titers of serum anti-GAD antibody (anti-GAD-Ab), higher than 100 U/ml. Three of the four patients started to have epileptic seizures in their 5th or 6th decade. Characteristic symptoms suggesting encephalitis or encephalopathy were absent at onset of these symptoms, which led to delayed diagnosis. All four patients developed two or three of cerebellar ataxia, neuropsychological impairment, and IDDM, by several years or decades after onset of TLE, even after seizure freedom in two patients. These abnormalities were indicators for suspecting the involvement of anti-GAD-Ab in the pathogenesis. Anti-GAD-Ab levels in the cerebrospinal fluid (CSF) were measured, which detected elevated CSF/serum anti-GAD-Ab ratio (≥ 1.0), suggesting intrathecal anti-GAD-Ab synthesis, in three of the four patients. The TLE symptoms were somewhat prolonged, but three of the four patients eventually achieved seizure freedom after immunotherapies with combinations of two or three anti-epileptic drugs. Serum anti-GAD Ab is recommended to be measured in patients with middle-aged onset TLE. Moreover, immune-modulating therapies including steroid pulse and intravenous immunoglobulin therapies could have ameliorated neurological complications, even in the chronic phase.

  112. 知らないと患者もあなたも損をするてんかん診療ABC!(第15回) 人生を変える「ビデオ脳波モニタリング」

    中里 信和, 神 一敬

    脳神経外科速報　24　(7)　794-797　2014/07

    Publisher: (株)メディカ出版

    ISSN： 0917-1495

  113. MEGによるてんかん病態の解析 脳磁図の"眼"でみるてんかんの病態生理

    柿坂 庸介, 岩崎 真樹, 神 一敬, 加藤 量広, 藤川 真由, 中里 信和

    日本生体磁気学会誌　27　(1)　16-17　2014/05

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  114. てんかん患者の被災直後の実態調査に基づいた災害に強い診療システムの提案

    中里 信和, 柿坂 庸介, 神 一敬, 岩崎 真樹, 渡辺 雅子, 兼子 直

    精神薬療研究年報　(46)　90-91　2014/03

    Publisher: (公財)先進医薬研究振興財団

    ISSN： 1346-1702

  115. 難治性てんかん患者における発作時心拍変動と心臓自律神経機能障害

    神一敬, 加藤量広, 板橋尚, 中里信和

    てんかん治療研究振興財団研究年報　25　2014

    ISSN： 0915-5902

  116. Remote Epilepsy Clinic using a Video Conferencing System Peer-reviewed

    Narisawa Ayumi, Narita Norio, Tominaga Teiji, Iwasaki Masaki, Jin Kazutaka, Nakasato Nobukazu

    Japanese Journal of Neurosurgery　23　(2)　136-140　2014

    Publisher: The Japanese Congress of Neurological Surgeons

    DOI： 10.7887/jcns.23.136 　

    ISSN： 0917-950X

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    &emsp;&emsp;Careful medical interviewing is crucial for the diagnosis of epilepsy. However, the number of available epileptologists is not adequate to serve the cities in Japanese regional areas. This study assessed the use of a video-conferencing system to hold a remote epilepsy clinic with the cooperation of a tertiary epilepsy center and a local public hospital in an area devastated by the Great East-Japan Earthquake and tsunami. The video-conferencing system established protocols to ensure the protection of personal information on the internet.<br>&emsp;&emsp;Epileptologists in Tohoku University Hospital (tertiary epilepsy center) interviewed outpatients in the Kesennuma City Hospital (local public hospital) via the video-conferencing system. Medications and physical examinations were performed at the Kesennuma City Hospital based on the recommendations of the epileptologists. Nine patients received consultations via the remote epilepsy clinic from March 2012 to February 2013. Treatment strategies were established in 4 patients with epilepsy. Differential diagnosis was established in the other 5 patients with episodes of loss of consciousness. The interviews were successfully performed with the same quality as face-to-face interviews. Such remote clinics using the video-conferencing system will be valuable for medical support and education in medically underserved areas. However, the current health insurance system does not cover the provision of such telemedicine services in Japan.

  117. False Lateralization of Seizure Onset by Scalp EEG in Non-lesional Temporal Lobe Epilepsy : A Surgical Case Report Peer-reviewed

    Iwasaki Masaki, Jin Kazutaka, Kato Kazuhiro, Osawa Shin-ichiro, Shimoda Yoshiteru, Nakasato Nobukazu, Tominaga Teiji

    Japanese Journal of Neurosurgery　23　(9)　744-749　2014

    Publisher: The Japanese Congress of Neurological Surgeons

    DOI： 10.7887/jcns.23.744 　

    ISSN： 0917-950X

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    &emsp;&emsp;Temporal lobe epilepsy (TLE) often presents bilateral epileptiform discharges on an electroencephalogram (EEG). Epileptic seizures originating in the hippocampus can be propagated to the contralateral hippocampus earlier than to the ipsilateral temporal neocortex, so that careful investigation is necessary to determine the side of epileptic focus in TLE.<br>&emsp;&emsp;A 35-year-old right-handed male was referred for surgical treatment of epilepsy. He started to have complex partial seizures at age 20, which were resistant to multiple antiepileptic medications. Brain MRI and interictal FDG-PET were both normal. Long-term video-EEG monitoring revealed bilateral temporal spikes interictally with ictal EEG changes starting in the right temporal region. Depth and subdural electrodes were implanted to the bilateral hippocampi and temporal neocortices to determine the laterality of the seizures. The invasive EEG revealed epileptic seizures originating in the left medial temporal structures with secondary propagation to the contralateral hippocampus. Left anterior temporal lobectomy and amygdalohippocampectomy rendered him seizure free for 12 months. Histopathological diagnosis was type I cortical dysplasia associated with mild hippocampal sclerosis.<br>&emsp;&emsp;Scalp EEG occasionally presents the first ictal changes in the contralateral side to the epileptic focus in TLE. There fore careful presurgical evaluation with bilateral depth and subdural electrodes is important to determine the laterality of the epileptic focus in TLE, especially when the neuroimaging study shows no obvious abnormalities.

  118. Software-assisted spike detection in long-term EEG Peer-reviewed

    Sakuraba Rie, Iwasaki Masaki, Jin Kazutaka, Itabashi Izumi, Kato Kazuhiro, Itabashi Hisashi, Nakasato Nobukazu

    Japanese Journal of Clinical Neurophysiology　42　(3)　78-83　2014

    Publisher: Japanese Society of Clinical Neurophysiology

    DOI： 10.11422/jscn.42.78 　

    ISSN： 1345-7101

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    Long-term video electroencephalography (LTVEEG) reading is time-consuming. BESA Epilepsy (BESAE) is a software package that detects and clusters spike-like events automatically, to assist manual interpretation. The software potentially improves the efficiency of LTVEEG reading, although it has not been applied clinically. In this study, we compared the localization of epileptic spikes between BESAE-assisted and conventional visual detection in 83 patients with suspected diagnoses of epilepsy (average age of 33 years ranging from 13 to 64; 31 males). The spike localization with the two methods was concordant in 55.4%, partially concordant in 20.5%, and discordant in 24.1%. The major reason for discordance was the presence of epileptic spikes missed by BESAE. The spike localization by means of BESAE-assisted detection was consistent with the clinical diagnosis in 75.9% of the patients. It took an average of 7 minutes 43 seconds for a BESAE-assisted review to analyze a 3-to-4-day LTVEEG record. This study showed that BESAE-assisted spike detection for LTVEEG is efficient and fairly reliable compared with visual detection. Further improvement is necessary for clinical application.

  119. Comparison of spike detection in long-term EEG between EEG-tech-trainees and a board-certified clinical neurophysiologist Peer-reviewed

    Itabashi Izumi, Iwasaki Masaki, Jin Kazutaka, Sakuraba Rie, Kato Kazuhiro, Itabashi Hisashi, Nakasato Nobukazu

    Japanese Journal of Clinical Neurophysiology　42　(4)　100-105　2014

    Publisher: Japanese Society of Clinical Neurophysiology

    DOI： 10.11422/jscn.42.100 　

    ISSN： 1345-7101

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    BESA Epilepsy (BESAE) is a software package that automatically detects spike-like activities and is expected to reduce the burden of EEG review by helping inexperienced reviewers accurately analyze EEGs. In this study, we investigated the concordance in BESAE-assisted spike detection by experienced and inexperienced reviewers. Eighty-three patients (13&ndash;64 years, 31 male) underwent an average of 80 hours of long-term video EEG monitoring (LTVEEG). Fifty-nine of 83 patients were diagnosed with localization-related epilepsy, 7 were diagnosed with generalized epilepsy, 10 were diagnosed with non-epilepsy disorders, and 7 were diagnosed with unclassified seizure disorders. BE-assisted EEG reviews were independently performed by EEG-tech trainees and a board-certified clinical neurophysiologist. We compared the interpretations and localizations of the interictal spikes between the two types of reviewers. In 91% of the cases, EEG-tech trainees and the board-certified clinical neurophysiologist reported the same interpretation and localization of spikes. The reasons for discordance were inaccurate interpretations (four patients) and overlooked spikes (four patients). BESAE-assisted EEG review was associated with a high rate of concordance between EEG-tech trainees and a board-certified clinical neurophysiologist. BESAE-assisted spike detection is a useful technique that helps inexperienced reviewers analyze EEGs with greater accuracy.

  120. てんかん発作と非てんかん性不随意運動の鑑別に苦慮した抗NMDA受容体脳炎の一例

    吉田 隼, 加藤 量広, 神 一敬, 板橋 尚, 中里 信和, 岩崎 真樹, 黒澤 和大, 大嶋 龍司, 向井 由幸, 西山 修平, 竪山 真規, 青木 正志

    臨床神経学　53　(9)　756-756　2013/09

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  121. Corpus callosotomy for children with intractable generalized epilepsy : factors for long-term seizure remission

    IWASAKI M, UEMATSU M, NAKAYAMA T, FUKUYO N, HAGINOYA K, JIN K, OSAWA S, NAKAZATO N, TOMINAGA T

    NO TO HATTATSU　45　(3)　195-198　2013/05/01

    Publisher: The Japanese Society of Child Neurology

    DOI： 10.11251/ojjscn.45.195 　

    ISSN： 0029-0831

  122. 【てんかんの診断と連携-プライマリ・ケア医に求められるてんかん診療-】 プライマリ・ケア医のためのてんかん薬物治療 抗てんかん薬の使い方入門

    神 一敬, 中里 信和

    治療　94　(10)　1686-1690　2012/10

    Publisher: (株)南山堂

    ISSN： 0022-5207

  123. 【てんかんの診断と連携-プライマリ・ケア医に求められるてんかん診療-】 心疾患による意識消失発作とてんかん発作の見分け方、そして抗てんかん薬による心機能障害について教えてください

    神 一敬

    治療　94　(10)　1742-1744　2012/10

    Publisher: (株)南山堂

    ISSN： 0022-5207

  124. テレビ会議システムで東日本大震災の被災地を結んだ遠隔てんかん外来

    中里 信和, 神 一敬, 成田 徳雄

    日本遠隔医療学会雑誌　8　(2)　137-138　2012/09

    Publisher: (一社)日本遠隔医療学会

    ISSN： 1880-800X

  125. 【神経・筋疾患の病態と診断・治療(II)】 てんかん

    神 一敬, 中里 信和

    医学と薬学　68　(2)　197-202　2012/08

    Publisher: (株)自然科学社

    ISSN： 0389-3898

  126. 標準脳へのspike mapping tool てんかんMEGの多角的分析を目指して

    奥村 栄一, 岩崎 真樹, 菅野 彰剛, 神 一敬, 板橋 尚, 大沢 伸一郎, 加藤 量広, 川島 隆太, 中里 信和

    日本生体磁気学会誌　25　(1)　104-105　2012/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  127. 小さな皮質形成異常に伴うてんかん棘波の信号源推定

    板橋 尚, 神 一敬, 岩崎 真樹, 奥村 栄一, 菅野 彰剛, 加藤 量広, 冨永 悌二, 川島 隆太, 永井 敏郎, 中里 信和

    日本生体磁気学会誌　25　(1)　106-107　2012/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  128. てんかん診療の新時代

    神 一敬, 岩崎 真樹, 冨永 悌二, 中里 信和

    Neurological Surgery　40　(1)　5-14　2012/01

    Publisher: (株)医学書院

    ISSN： 0301-2603

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    日本におけるてんかん診療をめぐる進歩として、長時間ビデオ脳波モニタリング検査、新規抗てんかん薬、切除術以外の外科治療について概説した。長時間ビデオ脳波モニタリング検査については、非てんかん発作の鑑別、術前精査を目的とした具体例を提示した。新規抗てんかん薬としてトピラマート、ラモトリギン、レベチラセタムを紹介した。また、難治性てんかんに対する外科治療として脳梁離断術、迷走神経刺激術について述べた。

  129. Physicians' emotional barriers toward epilepsy surgery

    Nakasato Nobukazu, Jin Kazutaka, Iwasaki Masaki, Itabashi Naoshi, Tominaga Teiji

    Rinsho Shinkeigaku　52　(11)　1080-1082　2012

    Publisher: Societas Neurologica Japonica

    DOI： 10.5692/clinicalneurol.52.1080 　

    ISSN： 0009-918X

    eISSN： 1882-0654

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    Guidelines for epilepsy recommend timely referral of potential surgical candidate to an epilepsy center for evaluation. However, many patients are never referred for evaluation, or referred even a few decades after medically intractable condition. Physician's negative attitudes toward surgery may increase risk of morbidity and mortality in epilepsy patients. The aim of this review is to identify barriers toward epilepsy surgery among physicians. Importance of long-term epilepsy monitoring is emphasized.<br>

  130. てんかんの診断と最新薬物治療 (Clinic Magazine)

    神一敬, 中里信和

    Clinic Magazine　8　(13)　42-45　2011/12

    Publisher: クリニックマガジン

  131. てんかん外科におけるMEGの役割：Multimodal fusion 画像での検討 (日本生体磁気学会誌)

    岩崎真樹, 神一敬, 奥村栄一, 大沢伸一郎, 菅野彰剛, 冨永悌二, 中里信和

    日本生体磁気学会誌　24　62-63　2011/06

  132. てんかん診療におけるビデオ脳波モニタリングの意義 (神経内科)

    神一敬, 板橋尚, 中里信和

    神経内科　75　539-544　2011/06

  133. てんかんで発症した多発性硬化症の1例

    加藤量広, 井泉瑠美子, 菅野直人, 神一敬, 中島一郎, 藤原一男

    てんかん研究　28　(3)　2011

    ISSN： 0912-0890

  134. 発症前長期にわたりAQP4抗体が陽性であったNMOの1例

    西山 修平, 伊藤 孝, 三須 建郎, 高橋 利幸, 菊池 昭夫, 鈴木 直輝, 神 一敬, 青木 正志, 藤原 一男, 糸山 泰人

    臨床神経学　49　(12)　1035-1035　2009/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  135. 神経疾患の診断・治療・予防に関する包括的臨床研究

    久永欣哉, 松本有史, 安藤肇史, 鈴木博義, 神一敬, 阿部憲男, 圓谷建治, 今野秀彦, 関晴朗, 飛田宗重, 藤盛寿一, 清水洋, 志賀裕正

    神経疾患の診断・治療・予防に関する包括的臨床研究 平成18-20年度 総括研究報告書　2009

  136. 脳幹病変を認め神経Behcet病が疑われた女性例の臨床的検討

    西山 修平, 菊池 昭夫, 加藤 量広, 三須 建郎, 神 一敬, 志賀 裕正, 藤原 一男, 糸山 泰人

    臨床神経学　48　(2)　147-147　2008/02

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  137. 長期人工呼吸管理下に気管腕頭動脈瘻からの急性出血で死亡した家族性ALSの1例 Peer-reviewed

    加藤量広, 鈴木直輝, 青木正志, 割田 仁, 神 一敬, 糸山泰人

    臨床神経学　48　(1)　60-62　2008

    DOI： 10.5692/clinicalneurol.48.60 　

    ISSN： 0009-918X 1882-0654

  138. パーキンソン病講座 睡眠・呼吸異常の新知見

    小野寺 宏, 神 一敬

    難病と在宅ケア　12　(10)　66-68　2007/01

    Publisher: (株)日本プランニングセンター

    ISSN： 1880-9200

  139. Comprehensive studies of neurologic diseases based on the policy medical treatment network. Discussion on classification of neurodegenerative disease with cognition disorder based on autopsy. Positioning of diffusive dementia with Lewy bodies and primary

    久永欣哉, 鈴木博義, 飛田宗重, 日沼雄二, 神一敬, 今野秀彦, 菅野重範, 深津玲子, 木村格

    政策医療ネットワークを基盤にした神経疾患の総合的研究 平成15-17年度 総括研究報告書　39-41　2006

  140. パーキンソン病講座 呼吸器合併症はパーキンソン病の寿命に影響

    小野寺 宏, 神 一敬, 金原 禎子

    難病と在宅ケア　10　(10)　43-46　2005/01

    Publisher: (株)日本プランニングセンター

    ISSN： 1880-9200

  141. 他領域にまたがる注意すべき脳神経精神症状とその治療 整形外科的症状(疾患)と神経疾患

    神 一敬, 志賀 裕正

    Mebio　21　(1)　77-81　2004/01

    Publisher: (株)メジカルビュー社

    ISSN： 0910-0474

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    神経内科は脳・脊髄から末梢神経・神経筋接合部・筋に至るまで,運動・感覚などに関する情報伝達経路のいずれかに障害が及ぶ疾患を対象としている.このうち脊髄・末梢神経の外科は整形外科の専門領域であり,これらの分野において両者の密接な連携が要求される.そこで,神経内科医が整形外科的疾患との鑑別診断に苦慮する場合のある疾患(頸椎症性筋萎縮,頸椎症性脊髄症,多発性単ニューロパチー,絞扼性ニューロパチ)について概説した

  142. レビー小体を伴う痴呆群の画像診断 定量的脳血流シンチグラフィーによる検討分

    望月 廣, 佐藤 信行, 飛田 宗重, 久永 欣哉, 神 一敬, 深津 玲子, 渋谷 聡, 及川 崇紀

    厚生労働省精神・神経疾患研究委託費総括研究報告書 神経疾患の予防・診断・治療に関する臨床研究　平成12〜14年度　40-41　2003/03

    Publisher: 厚生労働省精神・神経疾患研究班

  143. 両側の前骨間神経症候群を呈したneuralgic amyotrophyの1例

    鈴木 直輝, 神 一敬, 志賀 裕正, 加藤 宏之, 糸山 泰人

    脳と神経　54　(7)　605-608　2002/07

    Publisher: (株)医学書院

    ISSN： 0006-8969

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    49歳女.右上肢の挙上不可を主訴とした.両肩痛から始り右上肢帯の筋力低下と,数日後に左手の指関節屈曲障害が出現した.右三角筋,棘上筋,棘下筋,左右の長拇指屈筋に神経原生変化を認めた.右腋窩神経,右肩甲上神経に加え両側前骨間神経領域の障害が示唆されたが,正中神経,尺骨神経伝導検査は正常であった.他に異常なく,neuralgic amyotrophy(NA)と診断した.保存的に経過観察中であるが,発症から4ヵ月で右上肢近位筋の筋力低下はほぼ回復したが,両側前骨間神経症候群は回復していない.肩痛に引続き上肢帯の筋脱力・萎縮をきたした古典的な腕神経叢障害型NAで,両側性の前骨間神経症候群を呈した例は稀である

  144. A Case of Medial Medullary Infarction with Persistent Primitive Hypoglossal Artery Peer-reviewed

    54　(4)　341-345　2002/04

    Publisher: 医学書院

    ISSN： 1881-6096

  145. 神経疾患の予防・診断・治療に関する臨床研究 パーキンソン病群からみたレビー小体型痴呆群の検討

    望月 廣, 佐藤 信行, 神 一敬, 久永 欣哉

    厚生省精神・神経疾患研究委託費による研究報告集　平成12年度　481-481　2002/03

    Publisher: 国立精神・神経センター

    More details Close

    臨床的にdefinite DLBと診断した10例(男6名,女4名,平均71歳),パーキンソン病(PD)群は年齢対応した10例(男6名,女4名,平均69歳),対照は正常成人10例(男6名,女4名,平均63歳)とし,脳血流SPECTを比較し,DLB群の画像診断的特徴を検討した.99mTc-ECDによる半定量的な脳血流SPECT画像の比較検討で,DLB群はPD群に比し,後頭葉の血流低下が示され,視空間的認知異常との関連が示唆された.更にSPM96では,PD群に比してDLB群で左側頭後頭葉に有意な脳血流の低下が示された

  146. 【眼で見る神経内科】 脳腫瘍様の広汎な脱髄病変 mass effectをきたした多発性硬化症

    塚本 哲朗, 田口 謙, 神 一敬, 渋谷 聡, 粟飯原 直人

    神経内科　53　(Suppl.2)　136-137　2000/09

    Publisher: (有)科学評論社

    ISSN： 0386-9709

  147. 【眼で見る神経内科】 脳梁欠損症

    神 一敬, 加藤 昌昭, 佐藤 信行, 大沼 歩, 望月 廣

    神経内科　53　(Suppl.2)　368-369　2000/09

    Publisher: (有)科学評論社

    ISSN： 0386-9709

  148. 消化管出血で発症し興味ある画像を呈した十二指腸粘膜下腫瘍の1手術例

    神 一敬, 佐藤 勝久, 和田 靖, 浅野 重之

    磐城共立病院医報　21　(1)　109-113　2000/09

    Publisher: いわき市立総合磐城共立病院

    ISSN： 0916-3387

  149. パーキンソン病114例から検討したdiffuse Lewy body disease Peer-reviewed

    神 一敬, 佐藤 信行, 久永 欣哉, 鈴木 博義, 望月 廣

    臨床神経学　40　(4)　329-333　2000/04

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

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    パーキンソン病と診断した114例から,McKeithらによるdementia with Lewy bodiesの診断基準を一部修正した独自の診断基準により,6例をclinically definite &quot;diffuse Lewy body disease(DLBD)&quot;と診断した.中心症状である痴呆,中核症状であるパーキンソン症状,認知機能の変動,くりかえす幻視に加え,補助項目の中ではくりかえす不自然な転倒(4例),失神(5例),一過性の意識障害(全例)が多数例でみとめられた.2例は剖検にいたり,自律神経系をふくむ多系統でレビー小体がみとめられた.一方,中核症状のうち認知機能の変動を欠いたprobable DLBD,更に幻覚も欠いたpossible DLBDでは補助項目を認めなかった.これらの補助項目は自律神経障害や認知機能の変動との関連が想定でき,DLBDの臨床診断に際してはとくに注目すべき症状である

  150. 眼で見る神経内科 脳内針 縫い針はどのようにして頭蓋内に入ったか

    塚本 哲朗, 負門 克典, 神 一敬

    神経内科　51　(6)　572-573　1999/12

    Publisher: (有)科学評論社

    ISSN： 0386-9709

  151. 開頭脳生検により診断し得た多発性脳内結核腫の一例 Peer-reviewed

    佐久間 良, 神 一敬, 永井 真貴子

    臨床神経学　37　(10)　895-899　1997/10

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

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    糖尿病性腎不全で腎移植後,免疫抑制剤服用中の46歳男性.頭痛と発熱に続き小脳徴候が出現.MRIで多発性脳内病変を認めたが,CTガイド下定位脳生検や髄液検査では診断がつかず,画像所見より結核腫を疑い抗結核剤を開始,一時小康状態となった.その後,症状と画像所見が増悪,開頭脳生検を施行した.結核性肉芽腫病変を認め,抗酸菌染色と結核菌PCR陽性より脳内結核腫と確定,治療継続で病変は縮小した.脳内結核腫の診断には,針生検では結核腫の堅いcapsuleに弾かれ適切な検体が得られない事があり,必要に応じ開頭脳生検も積極的に考慮する必要がある

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Presentations 384

  1. 選択的麻酔薬動注と認知神経学的評価を組み合わせた精密な脳機能評価

    大沢 伸一郎, 鈴木 匡子, 柿沼 一雄, 勝頼 一登, 浮城 一司, 金森 政之, 下田 由輝, 新妻 邦泰, 松本 康史, 神 一敬, 中里 信和, 遠藤 英徳

    てんかん研究　2025/01

  2. 超選択的Wadaテストによって言語優位半球と言語性記憶の優位半球が異なることが明らかになった内側側頭葉てんかんの1症例

    菊地 花, 大沢 伸一郎, 柿沼 一雄, 太田 祥子, 勝瀬 一登, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    てんかん研究　2025/01

  3. 麻酔薬の頭蓋内選択的動注と認知神経学的評価を融合した任意脳領域の機能局在診断法

    大沢 伸一郎, 鈴木 匡子, 柿沼 一雄, 勝瀬 一登, 浮城 一司, 金森 政之, 下田 由輝, 新妻 邦泰, 松本 康史, 神 一敬, 中里 信和, 遠藤 英徳

    日本脳神経血管内治療学会学術集会抄録集　2024/11

  4. 小児期発症てんかん患者の成人科への移行体験に対する認識

    佐々木 匠, 入江 亘, 菅原 明子, 神 一敬, 中里 信和, 塩飽 仁

    てんかん研究　2024/09

  5. 深層学習を用いた単チャネル脳波のdensity spectral arrayによるてんかん発作と心因性非てんかん発作の鑑別

    此松 和俊, 柏田 祐樹, 久保田 隆文, 神 一敬, 高橋 健人, 黒田 直生人, 浮城 一司, 柿坂 庸介, 青木 正志, 中里 信和

    てんかん研究　2024/09

  6. 日本語版Epilepsy Self-Efficacy Scaleの妥当性・信頼性の検討

    高橋 健人, 藤川 真由, 田崎 勝也, 小川 舞美, 大友 風佳, 神 一敬, 中里 信和

    てんかん研究　2024/09

  7. 小児期に発症した焦点てんかん患者の成人科への移行時期と就労状況

    小川 舞美, 神 一敬, 浮城 一司, 藤川 真由, 大友 風佳, 高橋 健人, 此松 和俊, 久保田 隆文, 柿坂 庸介, 中里 信和

    てんかん研究　2024/09

  8. 後大脳動脈で灌流される海馬周囲構造への超選択的麻酔は記憶機能のモダリティ別評価を可能にする

    大沢 伸一郎, 鈴木 匡子, 柿沼 一雄, 勝瀬 一登, 菊地 花, 浮城 一司, 石田 誠, 下田 由輝, 新妻 邦泰, 神 一敬, 中里 信和, 遠藤 英徳

    てんかん研究　2024/09

  9. 超選択的Wadaテストによる脳領域別の言語機能推定

    柿沼 一雄, 大沢 伸一郎, 勝瀬 一登, 菊地 花, 太田 祥子, 川村 藍, 劉 軍艶, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    てんかん研究　2024/09

  10. Wadaテストにおける記憶スコアは言語機能領域への薬剤注入で低下しうる

    菊地 花, 大沢 伸一郎, 柿沼 一雄, 勝瀬 一登, 太田 祥子, 川村 藍, 劉 軍艶, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    てんかん研究　2024/09

  11. 強直間代発作がてんかんセルフスティグマに与える影響

    小川舞美, 藤川真由, 浮城一司, 此松和俊, 此松和俊, 久保田隆文, 久保田隆文, 柿坂庸介, 神一敬, 中里信和

    全国てんかんセンター協議会総会プログラム・抄録集　2024

  12. 後大脳動脈への超選択的麻酔薬注入による記憶機能のカテゴリ別評価

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝頼一登, 菊地花, 浮城一司, 石田誠, 新妻邦泰, 新妻邦泰, 神一敬, 中里信和, 遠藤英徳

    日本ヒト脳機能マッピング学会プログラム・抄録集　2024

  13. Verification for safety and efficacy of hydrogel-based organic electrode by physician-initiated clinical trial

    大沢伸一郎, 新妻邦泰, 中川敦寛, 新妻邦泰, 中川敦寛, 浮城一司, 下田由輝, 神一敬, 植松貢, 岩崎真樹, 西澤松彦, 中里信和, 冨永悌二, 遠藤英徳

    日本てんかん外科学会プログラム・抄録集　2024

  14. Association between postoperative neuroimaging and motor dysfunction in peri-rolandic epilepsy after focal cortical resection

    二宮敦彦, 大沢伸一郎, 鈴木匡子, 柿沼一雄, 浮城一司, 下田由輝, 鈴木博義, 宮田元, 神一敬, 植松貢, 中里信和, 遠藤英徳

    日本てんかん外科学会プログラム・抄録集　2024

  15. Efficacy of complete callosotomy in a case of sound-induced generalized tonic seizures

    浮城一司, 大沢伸一郎, 柿坂庸介, 神一敬, 冨永悌二, 遠藤英徳, 中里信和

    日本てんかん外科学会プログラム・抄録集　2024

  16. 海馬硬化を伴う内側側頭葉てんかんの術後発作転帰予測因子

    曽我 天馬, 神 一敬, 柿坂 庸介, 此松 和俊, 大沢 伸一郎, 岩崎 真樹, 鈴木 博義, 青木 正志, 中里 信和

    臨床神経学　2023/09

  17. 超選択的頭蓋内麻酔薬注入により、患者は焦点切除後の神経症状を主観的に評価できる

    大沢 伸一郎, 鈴木 匡子, 浮城 一司, 柿沼 一雄, 石田 誠, 新妻 邦泰, 神 一敬, 植松 貢, 中里 信和, 遠藤 英徳

    てんかん研究　2023/09

  18. MRI陰性側頭葉てんかんの術後発作転帰と発作時心拍数上昇の関係

    曽我 天馬, 神 一敬, 柿坂 庸介, 浮城 一司, 此松 和俊, 久保田 隆文, 大沢 伸一郎, 岩崎 真樹, 鈴木 博義, 青木 正志, 中里 信和

    てんかん研究　2023/09

  19. 片側扁桃体腫大を伴う側頭葉てんかん患者における発作時脳波の特徴

    此松 和俊, 神 一敬, 板橋 泉, 佐藤 志帆, 森下 陽平, 曽我 天馬, 柿坂 庸介, 麦倉 俊司, 青木 正志, 中里 信和

    てんかん研究　2023/09

  20. てんかん患者の就労における病名開示の決定に関与する要因の検討

    小川 舞美, 藤川 真由, 田崎 勝也, 柿坂 庸介, 神 一敬, 中里 信和

    てんかん研究　2023/09

  21. てんかん患者における日本語版Medical Outcomes Study Social Support Surveyの妥当性・信頼性の検討

    高橋 健人, 藤川 真由, 田崎 勝也, 小川 舞美, 大友 風佳, 柿坂 庸介, 神 一敬, 中里 信和

    てんかん研究　2023/09

  22. 中大脳動脈上行枝へのプロポフォール注入によって生じた再帰性発話

    柿沼 一雄, 大沢 伸一郎, 浮城 一司, 菅野 彰剛, 神 一敬, 石田 誠, 冨永 悌二, 中里 信和, 松田 実, 鈴木 匡子

    日本神経心理学会総会プログラム・予稿集　2023/08

  23. 側頭葉てんかん患者のセルフスティグマの予測因子

    小川 舞美, 藤川 真由, 田崎 勝也, 柿坂 庸介, 神 一敬, 中里 信和

    The Japanese Journal of Rehabilitation Medicine　2023/05

  24. Decision-making assessment for epilepsy surgery using MacArthur Competence Assessment Tools by a Certified Psychologist

    藤川真由, 藤川真由, 大沢伸一郎, 曽我天馬, 小川舞美, 高橋健人, 大友風佳, 本庄谷奈央, 柿坂庸介, 柿坂庸介, 神一敬, 神一敬, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集　2023

  25. The Role of the Clinical Laboratory Technician in Epilepsy Surgery

    石田誠, 大沢伸一郎, 神一敬, 柿坂庸介, 菅野彰剛, 浅黄優, 冨永悌二, 中里信和, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集　2023

  26. Myelin oligodendrocyte glycoprotein抗体関連疾患の脳波所見の特徴

    此松和俊, 此松和俊, 藤盛寿一, 金子仁彦, 神一敬, 三須建郎, 中島一郎, 中里信和, 青木正志

    日本神経学会学術大会プログラム・抄録集　2023

  27. MRI陰性例での脳磁図を用いたてんかん焦点評価 MRI陰性焦点てんかん患者における脳磁図の役割

    神 一敬, 石田 誠, 菅野 彰剛, 中里 信和

    臨床神経生理学　2022/10

  28. 問題症例のMEG 海馬硬化症を伴う左内側側頭葉てんかんにおけるMEGとfMRIによる言語左右差の不一致(Left mesial temporal epilepsy with hippocampal sclerosis showing discordance of language laterality between MEG and fMRI)

    古知 龍三郎, 神 一敬, 石田 誠, 菅野 彰剛, 大沢 伸一郎, 岩崎 真樹, 冨永 悌二, 中里 信和

    臨床神経生理学　2022/10

  29. 発作後心静止を呈したてんかん患者の臨床的特徴

    此松 和俊, 神 一敬, 曽我 天馬, 柿坂 庸介, 青木 正志, 中里 信和

    臨床神経生理学　2022/10

  30. 発作間欠期spike関連ripple解析を用いたてんかん原性部位の推定について

    植松 貢, 植松 有里佳, 平田 理絵, 大沢 伸一郎, 神 一敬, 岩崎 真樹, 中里 信和

    臨床神経生理学　2022/10

  31. 光突発反応を呈する焦点てんかん患者の臨床的特徴

    曽我 天馬, 神 一敬, 此松 和俊, 柿坂 庸介, 青木 正志, 中里 信和

    臨床神経生理学　2022/10

  32. てんかん原性病変の切除範囲〜取り切ることの意義を考える〜 てんかん原性病変の切除範囲Focal cortical dysplasiaについて

    大沢 伸一郎, 浮城 一司, 下田 由輝, 鈴木 匡子, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　2022/08

  33. 混乱するlow-grade epilepsy-associated neuroepithelial tumors(LEAT)の概念 切除外科の視点からLEAT概念を考える

    大沢 伸一郎, 浮城 一司, 下田 由輝, 鈴木 匡子, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　2022/08

  34. てんかん診療の近未来〜デバイスと医薬品開発の最前線〜 トンネル磁気抵抗効果を用いた頭皮密着型脳磁計の開発

    菅野 彰剛, 神 一敬, 柿坂 庸介, 石田 誠, 中里 信和, 大兼 幹夫, 安藤 康夫

    てんかん研究　2022/08

  35. 外科治療を行った小児期発症の島回・弁蓋部てんかん3例の検討

    植松 有里佳, 大沢 伸一郎, 堅田 有宇, 神 一敬, 中里 信和, 植松 貢

    てんかん研究　2022/08

  36. 海馬硬化を伴う内側側頭葉てんかんの臨床脳波的特徴

    曽我 天馬, 神 一敬, 大沢 伸一郎, 岩崎 真樹, 柿坂 庸介, 鈴木 博義, 青木 正志, 冨永 悌二, 中里 信和

    てんかん研究　2022/08

  37. 扁桃体腫大を伴う側頭葉てんかん患者における発作時脳波所見の特徴

    此松 和俊, 神 一敬, 佐藤 志帆, 森下 陽平, 曽我 天馬, 柿坂 庸介, 麦倉 俊司, 青木 正志, 中里 信和

    てんかん研究　2022/08

  38. Web会議システムを用いた遠隔外来による迷走神経刺激療法の外来刺激調整

    古知 龍三郎, 大沢 伸一郎, 成田 徳雄, 柴田 憲一, 村上 謙介, 柿坂 庸介, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　2022/08

  39. てんかん患者のセルフスティグマの予測因子

    小川 舞美, 藤川 真由, 田崎 勝也, 柿坂 庸介, 神 一敬, 中里 信和

    てんかん研究　2022/08

  40. 言語症状に対する内観と失語型との対応 超選択的Wadaテストによる検討

    柿沼 一雄, 大沢 伸一郎, 細川 大瑛, 親富祖 まりえ, 太田 祥子, 浮城 一司, 石田 誠, 神 一敬, 中里 信和, 新妻 邦泰, 冨永 悌二, 鈴木 匡子

    高次脳機能研究　2022/03

  41. 超選択的Wada Testにおける片麻痺に対する病態失認の検討

    細川 大瑛, 大沢 伸一郎, 柿沼 一雄, 太田 祥子, 親富祖 まりえ, 浮城 一司, 石田 誠, 神 一敬, 中里 信和, 新妻 邦泰, 冨永 悌二, 鈴木 匡子

    高次脳機能研究　2022/03

  42. Respective contribution of depth and subdural electrode by craniotomy in epilepsy surgery

    大沢伸一郎, 浮城一司, 鈴木匡子, 石田誠, 柿沼一雄, 植松貢, 下田由輝, 神一敬, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　2022

  43. Should we consider the indication of complete corpus callosotomy in cases with more than 10 years’ epilepsy duration?

    浮城一司, 浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 山本哲哉, 冨永悌二, 中里信和

    日本てんかん外科学会プログラム・抄録集　2022

  44. How to decide the resection extent for focal cortical dysplasia patient

    大沢伸一郎, 浮城一司, 下田由輝, 鈴木匡子, 神一敬, 中里信和, 冨永悌二

    てんかん研究　2022

  45. Concept of resective surgery for LEAT

    大沢伸一郎, 浮城一司, 下田由輝, 鈴木匡子, 神一敬, 中里信和, 冨永悌二

    てんかん研究　2022

  46. 皮質電気刺激によって誘発されたキネトプシア:側頭葉てんかん症例における検討

    柿沼一雄, 大沢伸一郎, 浮城一司, 篠田元気, 細川大瑛, 親富祖まりえ, 太田祥子, 石田誠, 神一敬, 冨永悌二, 中里信和, 鈴木匡子

    日本神経化学会大会抄録集(Web)　2022

  47. MRI陰性焦点てんかん患者における脳磁図の役割

    神一敬, 石田誠, 菅野彰剛, 中里信和

    臨床神経生理学(Web)　2022

  48. Left mesial temporal epilepsy with hippocampal sclerosis showing discordance of language laterality between MEG and fMRI

    古知龍三郎, 古知龍三郎, 神一敬, 石田誠, 菅野彰剛, 大沢伸一郎, 岩崎真樹, 冨永悌二, 中里信和

    臨床神経生理学(Web)　2022

  49. 側頭葉てんかんにおける脳磁図を用いた体性感覚機能マッピング

    石田誠, 神一敬, 菅野彰剛, 柿坂庸介, 中里信和, 中里信和

    日本ヒト脳機能マッピング学会プログラム・抄録集　2022

  50. Magnetoencephalography for the preoperative diagnosis of insulo-opercular epilepsy: report of 2 cases

    石田誠, 大沢伸一郎, 菅野彰剛, 柿坂庸介, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集　2022

  51. Utility of AI-based magnetoencephalography analysis in a case of frontal lobe epilepsy

    菅野彰剛, 菅野彰剛, 大沢伸一郎, 神一敬, 柿坂庸介, 石田誠, 石田誠, 浮城一司, 曽我天馬, 此松和俊, 植松貢, 中田乙一, 長谷川史裕, 平田雅之, 冨永悌二, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集　2022

  52. 麻酔薬の超選択的頭蓋内動脈による神経症状誘発は脳実質切除後の機能転帰を予測する

    大沢 伸一郎, 鈴木 匡子, 浮城 一司, 柿沼 一雄, 新妻 邦泰, 下田 由輝, 神 一敬, 中里 信和, 冨永 悌二

    脳血管内治療　2021/11

  53. てんかん脳磁図:当院のベスト・オブ・ザ・ベスト 脳磁図局在診断が有用であった弁蓋部と島の焦点てんかん2例

    石田 誠, 神 一敬, 菅野 彰剛, 大沢 伸一郎, 柿坂 庸介, 浮城 一司, 冨永 悌二, 中里 信和

    臨床神経生理学　2021/10

  54. 遠隔医療D to D:ひとりで悩まないために オンライン医学教育の意義と運用の実際 遠隔てんかん症例検討会の経験から

    柿坂 庸介, 神 一敬, 大沢 伸一郎, 中里 信和

    臨床神経生理学　2021/10

  55. 長時間ビデオ脳波モニタリングで発作間欠時てんかん性異常を認めない症例における脳磁図

    津田 理恵, 石田 誠, 菅野 彰剛, 鈴木 美野理, 柿坂 庸介, 神 一敬, 中里 信和

    臨床神経生理学　2021/10

  56. 包括的な臨床神経生理学的精査により明らかになった軽微なepilepsia partialis continuaの一例

    斉藤 聡志, 神 一敬, 上利 大, 石田 誠, 菅野 彰剛, 中里 信和

    臨床神経生理学　2021/10

  57. C-NORSE後てんかん患者3例の脳波・脳磁図所見の特徴

    久保田 隆文, 神 一敬, 曽我 天馬, 浮城 一司, 石田 誠, 菅野 彰剛, 柿坂 庸介, 青木 正志, 中里 信和

    臨床神経生理学　2021/10

  58. 頭蓋内動脈への超選択的麻酔薬注入による詳細な神経症状評価と手術適応への寄与

    大沢 伸一郎, 鈴木 匡子, 浮城 一司, 柿沼 一雄, 新妻 邦泰, 下田 由輝, 神 一敬, 中里 信和, 冨永 悌二

    臨床神経生理学　2021/10

  59. 成人期に長時間ビデオ脳波モニタリング検査を行った環状20番染色体症候群の2例

    曽我 天馬, 神 一敬, 柿坂 庸介, 浮城 一司, 伊澤 理香子, 青木 正志, 中里 信和

    臨床神経生理学　2021/10

  60. 特異な上肢ジストニー発作を認めた抗GABAb受容体抗体陽性脳炎の一例

    浮城 一司, 柿坂 庸介, 斉藤 聡志, 金子 仁彦, 横田 恵理, 神 一敬, 中里 信和

    臨床神経生理学　2021/10

  61. 低血糖発作からの急速な改善をビデオ脳波モニタリングで捉えたインスリノーマの1例

    此松 和俊, 柿坂 康介, 久保田 隆文, 曽我 天馬, 浮城 一司, 神 一敬, 中里 信和

    臨床神経生理学　2021/10

  62. 心拍変動のAI解析に基づく焦点起始両側強直間代発作検知アルゴリズムの検討

    芹野 真郷, 宮島 美穂, 藤原 幸一, 鈴木 陽子, 加納 学, 稲次 基希, 橋本 聡華, 中里 信和, 神 一敬, 星田 徹, 澤井 康子, 渡辺 裕貴, 山本 信二, 岩崎 真樹, 前原 健寿

    てんかん研究　2021/07

  63. てんかんオンライン・セカンドオピニオン 東日本大震災を契機として

    中里 信和, 柿坂 庸介, 神 一敬

    日本遠隔医療学会雑誌　2021/04

  64. オンライン教育のプレゼンテーションにおける残像効果のある「指マーカー機能」の有用性

    柿坂 庸介, 神 一敬, 大沢 伸一郎, 中里 信和

    日本遠隔医療学会学術大会プログラム・抄録集　2021/02

  65. オンライン医学教育の意義と運用の実際-遠隔てんかん症例検討会の経験から-

    柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

    臨床神経生理学(Web)　2021

  66. 超選択的Wada testにおける片麻痺に対する病態失認の検討

    細川大瑛, 細川大瑛, 大沢伸一郎, 柿沼一雄, 太田祥子, 親富祖まりえ, 浮城一司, 石田誠, 神一敬, 中里信和, 新妻邦泰, 新妻邦泰, 新妻邦泰, 冨永悌二, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　2021

  67. 言語症状に対する内観と失語型との対応:超選択的Wadaテストによる検討

    柿沼一雄, 大沢伸一郎, 細川大瑛, 細川大瑛, 親富祖まりえ, 太田祥子, 浮城一司, 石田誠, 神一敬, 中里信和, 新妻邦泰, 新妻邦泰, 新妻邦泰, 冨永悌二, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　2021

  68. A case of atypical somatotopy due to a peri-rolandic lesion predicted by evoked magnetic fields

    石田誠, 柿坂庸介, 菅野彰剛, 大沢伸一郎, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

    日本生体磁気学会誌　2021

  69. A case of frontal lobe epilepsy with focal aware seizures with eye and head version in which MEG was useful to localize epileptic focus.

    土屋真理夫, 石田誠, 大沢伸一郎, 浮城一司, 柿坂庸介, 菅野彰剛, 菅野彰剛, 神一敬, 張替宗介, 中里信和, 中里信和

    日本生体磁気学会誌　2021

  70. Recording probability and associated factors of psychogenic nonepileptic seizures during 3-day video EEG monitoring.

    岩城弘隆, 岩城弘隆, 岩城弘隆, 神一敬, 小川舞美, 谷口豪, 藤川真由, 藤川真由, 中里信和

    てんかん研究　2021

  71. Can scalp EEG findings predict seizure outcome after anterior temporal lobectomy in patients with MRI-negative FDG-PET-positive temporal lobe epilepsy?

    曽我天馬, 曽我天馬, 神一敬, 大沢伸一郎, 岩崎真樹, 青木正志, 中里信和

    てんかん研究　2021

  72. Acceptance of disability was decreased after the comprehensive diagnostic evaluation at Epilepsy Monitoring Unit

    小川舞美, 藤川真由, 藤川真由, 柿坂庸介, 神一敬, 中里信和

    てんかん研究　2021

  73. A case of atypical somatotopy due to a peri-rolandic lesion predicted by evoked magnetic fields

    石田誠, 柿坂庸介, 菅野彰剛, 大沢伸一郎, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

    日本生体医工学会大会プログラム・抄録集(Web)　2021

  74. A case of frontal lobe epilepsy with focal aware seizures with eye and head version in which MEG was useful to localize epileptic focus.

    土屋真理夫, 石田誠, 大沢伸一郎, 浮城一司, 柿坂庸介, 菅野彰剛, 菅野彰剛, 神一敬, 張替宗介, 中里信和, 中里信和

    日本生体医工学会大会プログラム・抄録集(Web)　2021

  75. 脳磁図局在診断が有用であった弁蓋部と島の焦点てんかん2例

    石田誠, 神一敬, 菅野彰剛, 大沢伸一郎, 柿坂庸介, 浮城一司, 冨永悌二, 中里信和, 中里信和

    臨床神経生理学(Web)　2021

  76. Age-related seizure outcome after one-stage complete corpus callosotomy

    浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 植松貢, 山本哲哉, 冨永悌二, 中里信和

    てんかん研究　2021

  77. Efficacy of medical cooperation system in epilepsy-surgery clinic in Aomori

    大沢伸一郎, 柿坂庸介, 浮城一司, 神一敬, 村上謙介, 川村強, 中里信和, 冨永悌二

    てんかん研究　2021

  78. てんかん患者の障害受容パターンと生物心理社会的特徴

    小川 舞美, 藤川 真由, 柿坂 庸介, 神一 敬, 上埜 高志, 中里 信和

    日本健康心理学会大会発表論文集　2020/11/16

  79. 若年ミオクロニーてんかん患者において持続時間の長い多棘波は薬剤抵抗性を示唆する

    土屋 真理夫, 神 一敬, 柿坂 庸介, 北澤 悠, 中里 信和

    臨床神経生理学　2020/10

  80. 症例から学ぶ脳波のピットフォール 全般てんかんと焦点てんかんの鑑別

    神 一敬

    臨床神経生理学　2020/10

  81. 拡大するてんかんの遠隔医療 てんかん診療における遠隔外来と包括的入院精査の相補的利用

    柿坂 庸介, 大沢 伸一郎, 成田 徳雄, 神 一敬, 冨永 悌二, 中里 信和

    臨床神経生理学　2020/10

  82. てんかん発作時脳波を極める 焦点発作の頭皮脳波

    神 一敬

    臨床神経生理学　2020/10

  83. 超選択的Wada testによるオーダーメイド的局所脳機能評価

    大沢 伸一郎, 鈴木 匡子, 浮城 一司, 柿沼 一雄, 上利 大, 新妻 邦泰, 神 一敬, 浅黄 優, 中里 信和, 冨永 悌二

    臨床神経生理学　2020/10

  84. 高齢者てんかんの脳波

    神 一敬

    臨床神経生理学　2020/10

  85. 焦点てんかん患者における発作後全般性脳波抑制と睡眠時の心拍変動異常との関連

    坂本 美佳, 神 一敬, 浅黄 優, 三木 俊, 中里 信和

    日本医学検査学会抄録集　2020/09

  86. てんかん発作検知の重要性 発作検知技術の現状と今後の展望

    神 一敬

    脳と発達　2020/08

  87. 左側頭後頭葉底面の皮質電気刺激により顔の幻視とパレイドリアを呈した1例

    細川 大瑛, 柿沼 一雄, 上利 大, 浮城 一司, 佐藤 貴文, 大沢 伸一郎, 神 一敬, 中里 信和, 富永 悌二, 鈴木 匡子

    高次脳機能研究　2020/03

  88. てんかん診療における遠隔外来と包括的入院精査の相補的利用

    柿坂庸介, 大沢伸一郎, 成田徳雄, 神一敬, 冨永悌二, 中里信和

    臨床神経生理学(Web)　2020

  89. Order-made evaluation of brain function by super-selective Wada test in the candidate patients of epilepsy surgery

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 神一敬, 中里信和, 冨永悌二

    日本ヒト脳機能マッピング学会プログラム・抄録集　2020

  90. 深部電極による機能マッピングで証明された中心溝深部の運動機能局在

    下田由輝, 下田由輝, 大沢伸一郎, 浮城一司, 上利大, 柿沼一雄, 古知龍三郎, 神一敬, 鈴木匡子, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　2020

  91. 超選択的Wada test時に発作と同様の症状を呈した2例

    古知龍三郎, 大沢伸一郎, 鈴木匡子, 浮城一司, 上利大, 柿沼一雄, 神一敬, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　2020

  92. 放線方向を主たる活動とした“bottom of sulcus”を呈する皮質形成異常前頭葉てんかん1症例への脳磁図を用いた解析

    菅野彰剛, 神一敬, 大沢伸一郎, 石田誠, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 冨永悌二, 中里信和

    日本てんかん外科学会プログラム・抄録集　2020

  93. オーダーメイド的脳機能評価における超選択的Wada testの有用性

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 神一敬, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　2020

  94. 脳磁図・脳波解析ソフトウエアElectroMagnetic Source Estimation:EMSEの使用経験

    菅野彰剛, 神一敬, 柿坂庸介, 上利大, 冨田教幸, PFLIEGER Mark E., 中里信和, 中里信和

    日本ヒト脳機能マッピング学会プログラム・抄録集　2020

  95. Super-selective infusion of propofol to posterior cerebral artery predict post-operative macular sparing in the case of occipital lobe epilepsy with bilateral occipital injury

    古知龍三郎, 大沢伸一郎, 鈴木匡子, 浮城一司, 上利大, 柿沼一雄, 金森政之, 神一敬, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　2020

  96. Surgical indication and treatment strategy for the patients with epileptic foci in sensory-motor cortex

    大沢伸一郎, 鈴木匡子, 浮城一司, 神一敬, 植松貢, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　2020

  97. てんかんオンライン・セカンドオピニオン 東日本大震災を契機として

    中里 信和, 柿坂 庸介, 神 一敬

    JTTA Spring Conference 抄録集　2020/01

  98. 特異な眼球運動を伴う非定型欠神発作を認めた歯状核赤核淡蒼球ルイ体萎縮症の一例

    浮城 一司, 神 一敬, 豊嶋 昌弥, 柿坂 庸介, 上利 大, 土屋 真理夫, 中里 信和

    てんかん研究　2020/01

  99. 発作時に気分高揚を示唆する言動を呈した右内側側頭葉てんかんの一例

    土屋 真理夫, 神 一敬, 柿坂 庸介, 大沢 伸一郎, 上利 大, 浮城 一司, 中里 信和

    てんかん研究　2020/01

  100. 超選択的Wada testによる血管解剖と機能解剖のハイブリッド評価

    大沢 伸一郎, 鈴木 匡子, 新妻 邦泰, 浮城 一司, 柿沼 一雄, 上利 大, 神 一敬, 斎藤 竜太, 金森 政之, 中里 信和, 冨永 悌二

    脳血管内治療　2019/11

  101. 持続脳波モニタリングを用いた非けいれん性てんかん重積の診断過程

    上利 大, 神 一敬, 大沢 伸一郎, 川副 友, 浅黄 優, 中里 信和

    臨床神経生理学　2019/10

  102. MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例

    菅野 彰剛, 神 一敬, 大沢 伸一郎, 柿坂 庸介, 上利 大, 浮城 一司, 土屋 真理夫, 佐藤 志帆, 麦倉 俊司, 中里 信和

    臨床神経生理学　2019/10

  103. てんかん外科に必要な術中マッピング 超選択的Wada testによるオーダーメイド的脳機能評価

    大沢 伸一郎, 鈴木 匡子, 浮城 一司, 柿沼 一雄, 上利 大, 浅黄 優, 新妻 邦泰, 三木 俊, 神 一敬, 中里 信和, 冨永 悌二

    臨床神経生理学　2019/10

  104. 遠隔てんかん症例検討会 いかにテレビ会議システムの教育的効果を最大化させるか

    柿坂 庸介, 神 一敬, 上利 大, 土屋 真理夫, 浮城 一司, 大沢 伸一郎, 中里 信和

    日本遠隔医療学会学術大会プログラム・抄録集　2019/10

  105. てんかん患者の浴槽内突然死は溺水ではなくSUDEPである

    神 一敬, 林 紀乃, 永森 千寿子, 岡成 和夫, 岡西 徹, 本間 陽一郎, 飯村 康司, 宇田 武弘, 高田 倫, 大坪 宏

    てんかん研究　2019/09

  106. 発作間欠時てんかん性脳波異常のみられない焦点てんかん患者に対する包括的てんかん精査の有用性

    鈴木 美野理, 神 一敬, 上利 大, 北澤 悠, 柿坂 庸介, 浅黄 優, 三木 俊, 中里 信和

    てんかん研究　2019/09

  107. てんかんへの心理的適応 障害受容の役割

    小川 舞美, 藤川 真由, 柿坂 庸介, 神 一敬, 上埜 高志, 中里 信和

    てんかん研究　2019/09

  108. てんかん患者の離職理由の質的研究

    植田 和, 藤川 真由, 小川 舞美, 神 一敬, 本庄谷 奈央, 上埜 高志, 中里 信和

    てんかん研究　2019/09

  109. 超選択的Wada testによるオーダーメイド的脳機能評価

    大沢 伸一郎, 鈴木 匡子, 新妻 邦泰, 浮城 一司, 柿沼 一雄, 上利 大, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　2019/09

  110. 若年ミオクロニーてんかんの発作時脳波の多様性

    土屋 真理夫, 神 一敬, 浮城 一司, 上利 大, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　2019/09

  111. 高齢症例の脳梁離断術における術式選択と術後転帰の検討

    浮城 一司, 大沢 伸一郎, 岩崎 真樹, 柿坂 庸介, 神 一敬, 山本 哲哉, 冨永 悌二, 中里 信和

    てんかん研究　2019/09

  112. 特発性全般てんかんでは、クロノタイプは夜型で日中は過度の眠気を呈しやすい

    原 瑞季, 神 一敬, 上利 大, 柿坂 庸介, 浅黄 優, 三木 俊, 中里 信和

    てんかん研究　2019/09

  113. 側頭葉および前頭葉てんかんにおける発作起始の睡眠段階の違い

    板橋 泉, 神 一敬, 浅黄 優, 上利 大, 柿坂 庸介, 三木 俊, 中里 信和

    てんかん研究　2019/09

  114. てんかん関連脳磁図 東北大学における最新の知見

    菅野 彰剛, 神 一敬, 柿坂 庸介, 上利 大, 石田 誠, 大沢 伸一郎, 中里 信和

    てんかん研究　2019/09

  115. 病型間で比較したてんかん患者における睡眠の問題に関する質問紙調査

    原 瑞季, 神 一敬, 上利 大, 柿坂 庸介, 三木 俊, 中里 信和

    日本睡眠学会定期学術集会プログラム・抄録集　2019/06

  116. Neurosomnology-睡眠・覚醒からみた脳神経疾患 睡眠覚醒周期とてんかん

    神 一敬

    日本睡眠学会定期学術集会プログラム・抄録集　2019/06

  117. 脳梁離断術後の急性離断症状改善経過

    浮城一司, 大沢伸一郎, 岩崎真樹, 神一敬, 山本哲哉, 冨永悌二, 中里信和

    日本てんかん外科学会プログラム・抄録集　2019

  118. 言語優位半球下前頭回深部の電気刺激による音認知の変容

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 古知龍三郎, 神一敬, 中里信和, 冨永悌二

    日本ヒト脳機能マッピング学会プログラム・抄録集　2019

  119. Wada testの発展的手法により明らかになった非典型的な言語局在の症例

    柿沼一雄, 大沢伸一郎, 菅野彰剛, 浮城一司, 上利大, 柿坂庸介, 神一敬, 冨永悌二, 中里信和, 鈴木匡子

    日本ヒト脳機能マッピング学会プログラム・抄録集　2019

  120. てんかん関連脳磁図:東北大学における最新の知見

    菅野彰剛, 神一敬, 柿坂庸介, 上利大, 石田誠, 大沢伸一郎, 中里信和

    てんかん研究　2019

  121. 新ガイドライン てんかんと運転免許

    神 一敬

    臨床神経学　2018/12

  122. 選択的後大脳動脈Wade testによる海馬機能評価

    大沢 伸一郎, 新妻 邦泰, 鈴木 匡子, 岩崎 真樹, 佐藤 健一, 遠藤 英徳, 松本 康史, 神 一敬, 中里 信和, 冨永 悌二

    脳血管内治療　2018/11

  123. 睡眠関連疾患と神経内科領域のcommon diseases-5 睡眠関連てんかん

    神 一敬

    神経治療学　2018/11

  124. てんかんと痙攣のアップデート2018-1 国際抗てんかん連盟(ILAE)による新しい発作型分類およびてんかん分類

    神 一敬

    神経治療学　2018/11

  125. 脳磁図の電流双極子モデルによる解析が不十分でてんかん切除術後に発作が残存した2症例における追加解析

    菅野 彰剛, 神 一敬, 石田 誠, 柿坂 庸介, 上利 大, 大沢 伸一郎, 岩崎 真樹, 中里 信和

    臨床神経生理学　2018/10

  126. 2連電気刺激を用いた同一脳回皮質-皮質間誘発電位によるてんかん性異常の検出

    佐藤 貴文, 大沢 伸一郎, 岩崎 真樹, 神 一敬, 三木 俊, 冨永 悌二, 中里 信和

    臨床神経生理学　2018/10

  127. てんかん患者における質問紙を用いた睡眠の問題の評価

    原 瑞季, 神 一敬, 上利 大, 柿坂 庸介, 三木 俊, 中里 信和

    臨床神経生理学　2018/10

  128. レセプトデータベースに基づく妊娠前、妊娠中、および出産後の抗てんかん薬処方状況の評価

    石川 智史, 小原 拓, 神 一敬, 西郡 秀和, 都田 桂子, 鈴鹿 雅人, 赤沢 学, 中里 信和, 八重樫 伸生, 栗山 進一, 眞野 成康

    日本薬剤疫学会学術総会抄録集　2018/10

  129. 遠隔医療・オンライン診療は何をもたらすのか

    中里信和, 柿坂庸介, 神一敬

    てんかん研究　2018/09/12

  130. 多数のCD34陽性細胞の出現を伴う分類困難なlow-grade gliomaの3例

    岡 直美, 岩崎 真樹, 大沢 伸一郎, 金森 政之, 神 一敬, 宮田 元, 渡辺 みか, 中里 信和, 上之原 広司, 鈴木 博義

    Brain Tumor Pathology　2018/09

  131. てんかん切除術後に発作が残存した2症例における脳磁図の追加解析

    菅野 彰剛, 神 一敬, 石田 誠, 柿坂 庸介, 上利 大, 大沢 伸一郎, 岩崎 真樹, 中里 信和

    てんかん研究　2018/09

  132. 大学病院てんかん科における医学科学生実習カリキュラム

    柿坂 庸介, 神 一敬, 藤川 真由, 北澤 悠, 上利 大, 高山 裕太郎, 小川 舞美, 中里 信和

    てんかん研究　2018/09

  133. 選択的後大脳動脈Wada testによる海馬機能評価

    大沢 伸一郎, 岩崎 真樹, 鈴木 匡子, 新妻 邦泰, 松本 康史, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　2018/09

  134. 心理職から提供できること

    小川 舞美, 藤川 真由, 佐久間 篤, 神 一敬, 中里 信和

    てんかん研究　2018/09

  135. 若年ミオクロニーてんかんの多剤併用療法における薬剤選択

    北澤 悠, 神 一敬, 柿坂 庸介, 藤川 真由, 中里 信和, 田中 章景

    てんかん研究　2018/09

  136. てんかん患者の離職回数に影響しうる生物心理社会的要因

    植田 和, 藤川 真由, 小川 舞美, 柿坂 庸介, 神 一敬, 上埜 高志, 中里 信和

    てんかん研究　2018/09

  137. 側頭葉てんかん患者におけるbenign epileptiform transients of sleepの脳磁図所見

    上利 大, 神 一敬, 柿坂 庸介, 菅野 彰剛, 石田 誠, 中里 信和

    てんかん研究　2018/09

  138. 頭蓋内高周波振動(HFO)に対するプロポフォールの影響

    櫻庭 理絵, 大沢 伸一郎, 奥村 栄一, 岩崎 真樹, 神 一敬, 冨永 悌二, 三木 俊, 中里 信和

    てんかん研究　2018/09

  139. 焦点性てんかん患者における発作後全般性脳波抑制とノンレム睡眠時の心拍変動異常との関連

    坂本 美佳, 神 一敬, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　2018/09

  140. 良性成人型家族性ミオクローヌスてんかんの患者で発作間欠時に認めたPhantom spike and waveと振戦様ミオクローヌスとの関連について

    上利大, 柿坂庸介, 神一敬, 高山裕太郎, 北澤悠, 藤川真由, 菅野彰剛, 菅野彰剛, 中里信和, 中里信和

    てんかん研究　2018

  141. 半球間裂深部のてんかん性活動を脳磁図で検出した右前頭葉てんかん1例

    石田誠, 菅野彰剛, 菅野彰剛, 柿坂庸介, 柿坂庸介, 神一敬, 神一敬, 岩崎真樹, 大沢伸一郎, 北澤悠, 冨永悌二, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集　2018

  142. 松果体部胚細胞腫瘍に対する集学的治療後に発症したてんかん患者の臨床的特徴

    高山裕太郎, 柿坂庸介, 大沢伸一郎, 神一敬, 菅野彰剛, 菅野彰剛, 岩崎真樹, 北澤悠, 上利大, 冨永悌二, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集　2018

  143. 良性成人型家族性ミオクローヌてんかんの患者で発作間欠時に認めたPhantom spike and waveと振戦様ミオクローヌスとの関連について

    上利 太, 柿坂 庸介, 神 一敬, 高山 裕太郎, 北澤 悠, 藤川 真由, 菅野 彰剛, 中里 信和

    てんかん研究　2018/01

  144. 発作時に無関心を思わせる態度を示した右前頭葉てんかんの1例

    高山 裕太郎, 柿坂 庸介, 神 一敬, 北澤 悠, 上利 大, 藤川 真由, 菅野 彰剛, 西尾 慶之, 中里 信和

    てんかん研究　2018/01

  145. 発作間欠期に視空間認知障害と精神病症状を呈したJeavons症候群の一例

    岩城 弘隆, 柿坂 庸介, 藤川 真由, 神 一敬, 中里 信和, 兼子 直

    てんかん研究　2018/01

  146. てんかんモニタリングユニットで終夜睡眠ポリグラフを行うことにより何が分かるか?

    鈴木 美野理, 神 一敬, 北澤 悠, 柿坂 庸介, 中里 信和

    臨床神経生理学　2017/10

  147. 主成分分析により発作症状に合致した伝播現象を説明できた難治てんかん2例

    菅野 彰剛, 石田 誠, 神 一敬, 柿坂 庸介, 北澤 悠, 高山 裕太郎, 上利 大, 中里 信和

    臨床神経生理学　2017/10

  148. 脳磁図により成人てんかん患者で計測できた体性感覚誘発性棘波様活動

    石田 誠, 菅野 彰剛, 柿坂 庸介, 神 一敬, 北澤 悠, 中里 信和

    臨床神経生理学　2017/10

  149. ビデオ脳波モニタリングユニット(EMU)を支えるコメディカルの役割 頭蓋内長時間脳波記録・判読における臨床検査技師の役割

    櫻庭 理絵, 大沢 伸一郎, 神 一敬, 岩崎 真樹, 中里 信和

    臨床神経生理学　2017/10

  150. てんかん学と臨床神経生理学との接点 その最新知見と臨床応用 てんかんと自律神経Update 神経内科の立場から

    神 一敬

    臨床神経生理学　2017/10

  151. 強直間代発作に伴い肩関節脱臼を呈したてんかん患者3例

    上利 大, 神 一敬, 加藤 量広, 高山 裕太郎, 北澤 悠, 藤川 真由, 柿坂 庸介, 菅野 彰剛, 中里 信和

    てんかん研究　2017/09

  152. てんかん患者における就労の関連因子 文献レビュー

    植田 和, 藤川 真由, 小川 舞美, 岩城 弘隆, 神 一敬, 上埜 高志, 中里 信和

    てんかん研究　2017/09

  153. 日本語版Epilepsy Stigma Scaleの作成とその信頼性および妥当性の検討

    小川 舞美, 藤川 真由, 岩城 弘隆, 植田 和, 北澤 悠, 柿坂 庸介, 神 一敬, 上埜 高志, 中里 信和

    てんかん研究　2017/09

  154. 発作起始の睡眠段階と時間帯に着目した強直間代発作の鑑別診断

    新村 彩香, 神 一敬, 板橋 泉, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　2017/09

  155. てんかんモニタリングユニットに入院する患者の看護師に求めるニーズに関する研究

    高坂 緒里恵, 矢切 恵美子, 小山 千尋, 原子 夏美, 狩野 修代, 山内 かず子, 及川 千代, 神 一敬

    日本脳神経看護研究学会会誌　2017/09

  156. 胚芽異形成性神経上皮腫瘍(DNT)と神経節膠腫における脳磁図所見の観察

    高山 裕太郎, 神 一敬, 柿坂 庸介, 菅野 彰剛, 岩崎 真樹, 石田 誠, 大沢 伸一郎, 北澤 悠, 上利 大, 中里 信和

    てんかん研究　2017/09

  157. ペランパネル治療に対するカルバマゼピン併用の影響

    岩城 弘隆, 神 一敬, 立川 和裕, 藤川 真由, 柿坂 庸介, 中里 信和, 兼子 直

    てんかん研究　2017/09

  158. 発作間欠時てんかん性脳波異常のみられないてんかん患者の臨床的特徴

    鈴木 美野理, 神 一敬, 北澤 悠, 柿坂 庸介, 菅野 彰剛, 中里 信和

    てんかん研究　2017/09

  159. 睡眠段階に着目したてんかん患者の心拍変動解析

    坂本 美佳, 神 一敬, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　2017/09

  160. 神経救急患者のけいれん性疾患の診断予測に与える乳酸値測定の有用性 連続661症例の検討から

    大沢 伸一郎, 藤田 健亮, 神 一敬, 柿坂 庸介, 川村 強, 今 明秀, 久志本 成樹, 中里 信和, 冨永 悌二

    てんかん研究　2017/09

  161. てんかんモニタリングユニットにおける発作時ビデオ脳波の記録と判読

    神 一敬

    てんかん研究　2017/09

  162. 遠隔医療(脳波とテレメディスン) 遠隔テレビ会議システムを用いたてんかん症例検討会

    柿坂 庸介, 神 一敬, 北澤 悠, 藤川 真由, 中里 信和

    てんかん研究　2017/09

  163. 高齢者てんかん(脳卒中後、重積、認知症、自己免疫) 高齢者てんかんと自己免疫

    神 一敬

    てんかん研究　2017/09

  164. レベチラセタムは化学物質過敏症の症状緩和に有効かもしれない

    柿坂 庸介, 神 一敬, 北澤 悠, 藤川 真由, 加藤 量広, 中里 信和

    日本臨床環境医学会総会プログラム・抄録集　2017/06

  165. 解離性障害を背景とする心因性非てんかん発作の予後因子の検討

    岩城 弘隆, 藤川 真由, 宮崎 直子, 神 一敬, 中里 信和, 兼子 直

    てんかん研究　2017/01

  166. 睡眠時と覚醒時に発作時発話を呈した傍シルビウス裂多小脳回の1例

    北澤 悠, 柿坂 庸介, 神 一敬, 藤川 真由, 田中 章景, 中里 信和

    てんかん研究　2017/01

  167. 特発性全般てんかんと前頭葉てんかんの鑑別における概日リズムの重要性

    新村 彩香, 板橋 泉, 神 一敬, 北澤 悠, 柿坂 庸介, 中里 信和

    臨床神経生理学　2016/10

  168. 若年ミオクロニーてんかんにカルバマゼピンは有効か?

    北澤 悠, 神 一敬, 柿坂 庸介, 藤川 真由, 田中 章景, 中里 信和

    てんかん研究　2016/09

  169. 病状説明がてんかん患者の心理社会面に及ぼす影響

    小川 舞美, 藤川 真由, 岩城 弘隆, 北澤 悠, 柿坂 庸介, 神 一敬, 中里 信和, 上埜 高志

    てんかん研究　2016/09

  170. Subcortical band heterotopiaを伴う難治てんかんに対し脳梁離断術を行った3例

    大沢 伸一郎, 岩崎 真樹, 下田 由輝, 神 一敬, 柿坂 庸介, 植松 貢, 萩野谷 和裕, 中里 信和, 冨永 悌二

    てんかん研究　2016/09

  171. MRIで病巣を確認できない側頭葉てんかんの外科治療

    岩崎 真樹, 神 一敬, 西尾 慶之, 柿坂 庸介, 大沢 伸一郎, 下田 由輝, 中里 信和, 冨永 悌二

    てんかん研究　2016/09

  172. 脳波技師の育成

    神 一敬, 中里 信和

    てんかん研究　2016/09

  173. SUDEPを探る 成人におけるSUDEP

    神 一敬

    てんかん研究　2016/09

  174. てんかん診療update ビデオ脳波と新規抗てんかん薬

    神 一敬

    神経治療学　2016/03

  175. 側頭葉てんかんの術前評価における海馬VolumetryとT2 Relaxometryの有用性

    佐藤 志帆, 麦倉 俊司, 舘脇 康子, 加藤 裕美子, 村田 隆紀, 高瀬 圭, 高橋 昭喜, 岩崎 真樹, 冨永 悌二, 神 一敬, 中里 信和, 鈴木 博義

    Japanese Journal of Radiology　2016/02

  176. 側頭葉てんかんの発作側方性と発作時心拍変化

    加藤 量広, 神 一敬, 柿坂 庸介, 北澤 悠, 岩崎 真樹, 藤川 真由, 青木 正志, 中里 信和

    臨床神経学　2015/12

  177. 治療抵抗性若年ミオクロニーてんかんにおける焦点性脳波異常

    北澤 悠, 神 一敬, 加藤 量広, 柿坂 庸介, 藤川 真由, 岩崎 真樹, 田中 章景, 中里 信和

    臨床神経生理学　2015/10

  178. てんかんの心臓自律神経モニタリング 側頭葉てんかん患者における発作時頻拍

    神 一敬, 加藤 量広, 中里 信和

    臨床神経生理学　2015/10

  179. 2連刺激皮質誘発反応を用いたてんかん患者の皮質興奮性の評価

    佐藤 貴文, 岩崎 真樹, 神 一敬, 冨永 悌二, 中里 信和

    てんかん研究　2015/09

  180. 発作間欠時棘波の電位分布の広さと脳梁離断術後の発作予後の関連

    今 沙也香, 岩崎 真樹, 櫻庭 理絵, 神 一敬, 冨永 悌二, 中里 信和

    てんかん研究　2015/09

  181. 側頭葉てんかん患者におけるMEG言語機能局在診断

    石田 誠, 岩崎 真樹, 菅野 彰剛, 神 一敬, 川島 隆太, 中里 信和

    てんかん研究　2015/09

  182. 成人側頭葉てんかん患者におけるQuality of Lifeの決定要因(Determinants of Quality of Life Among Adults with Temporal Lobe Epilepsy)

    藤川 真由, 西尾 慶之, 岩城 弘隆, 北澤 悠, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 神 一敬, 中里 信和

    てんかん研究　2015/09

  183. 側頭葉てんかんの脳画像病変に対応した特徴的発作時脳波所見

    板橋 泉, 神 一敬, 佐藤 志帆, 岩崎 真樹, 北澤 悠, 柿坂 庸介, 鈴木 博義, 中里 信和

    てんかん研究　2015/09

  184. 睡眠・覚醒リズム、概日リズムに注目した強直間代発作の鑑別

    新村 彩香, 板橋 泉, 神 一敬, 岩崎 真樹, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　2015/09

  185. 睡眠ステージの違いがfast ripples(200-500Hz)の分布に与える影響

    櫻庭 理絵, 岩崎 真樹, 奥村 栄一, 神 一敬, 冨永 悌二, 中里 信和

    てんかん研究　2015/09

  186. 定位放射線治療後の薬剤難治性てんかんに対する外科治療

    大沢 伸一郎, 岩崎 真樹, 下田 由輝, 神 一敬, 柿坂 庸介, 中里 信和, 川岸 潤, 城倉 英史, 冨永 悌二

    てんかん研究　2015/09

  187. T2 Relaxometryによる海馬てんかん原性の評価

    岩崎 真樹, 佐藤 志帆, 麦倉 俊司, 大沢 伸一郎, 下田 由輝, 神 一敬, 高橋 昭喜, 中里 信和, 冨永 悌二

    てんかん研究　2015/09

  188. 左手のtwitchingを呈したepilepsia partialis continuaにおいて脳波脳磁図所見に乖離がみられた一例

    柿坂 庸介, 岩崎 真樹, 神 一敬, 北澤 悠, 藤川 真由, 中里 信和, So Norman

    てんかん研究　2015/09

  189. 東北大学てんかん科における東日本大震災直後の2週間

    中里 信和, 神 一敬, 岩崎 真樹

    てんかん研究　2015/09

  190. 睡眠とてんかん てんかん発作による覚醒とノンレムパラソムニア

    神 一敬

    てんかん研究　2015/09

  191. てんかん診療update ビデオ脳波と新規抗てんかん薬

    神 一敬

    神経治療学　2015/09

  192. てんかん発作?非てんかん発作? 鑑別から治療まで

    神 一敬

    子どもの心とからだ　2015/08

  193. バルプロ酸・ラモトリギン・レベチラセタムの3剤併用で発作消失に至った難治性若年ミオクロニーてんかんの3例

    北澤 悠, 神 一敬, 柿坂 庸介, 藤川 真由, 中里 信和, 加藤 量広, 岩崎 真樹, 田中 章景

    臨床神経学　2015/07

  194. REM睡眠関連発作が記録された側頭葉外てんかん患者3例

    神 一敬, 中村 美輝, 板橋 泉, 加藤 量広, 北澤 悠, 柿坂 庸介, 岩崎 真樹, 中里 信和

    日本睡眠学会定期学術集会プログラム・抄録集　2015/07

  195. NREM睡眠時にのみ局所性発作起始を呈した側頭・頭頂・後頭葉てんかん患者3例

    板橋 泉, 神 一敬, 岩崎 真樹, 北澤 悠, 加藤 量広, 柿坂 庸介, 中里 信和

    日本睡眠学会定期学術集会プログラム・抄録集　2015/07

  196. Lennox-Gastaut症候群を呈した視床下部過誤腫の一例

    渡辺 靖章, 神 一敬, 高橋 健太, 柿坂 庸介, 北澤 悠, 藤川 真由, 中里 信和, 加藤 量広, 青木 正志, 岩崎 真樹

    臨床神経学　2015/07

  197. 1-A-D-26. Pre-operative magnetoencephalographic spike localization in patients with surgically-cured epilepsy

    Makoto Ishida, Masaki Iwasaki, Akitake Kanno, Kazutaka Jin, Yosuke Kakisaka, Kazuhiro Kato, Ryuta Kawashima, Nobukazu Nakasato

    Clinical Neurophysiology　2015/06

  198. 外科的に治療したてんかん患者における術前のMEG上でのスパイクの局在性(Pre-operative MEG spike localization in patients with surgically-cured epilepsy)

    Ishida Makoto, Iwasaki Masaki, Jin Kazutaka, Kanno Akitake, Asagi Suguru, Miki Takashi, Kawashima Ryuta, Nakasato Nobukazu

    医学検査　2015/05

  199. 経シルビウス裂的な海馬到達法と海馬切除

    岩崎真樹, 大沢伸一郎, 下田由輝, 神一敬, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　2015

  200. 側頭葉てんかん患者におけるMEG言語マッピング

    石田誠, 岩崎真樹, 菅野彰剛, 神一敬, 川島隆太, 中里信和

    日本ヒト脳機能マッピング学会プログラム・抄録集　2015

  201. 重症頭部外傷の既往がある海馬硬化症に伴う内側側頭葉てんかんの一手術例

    北澤 悠, 神 一敬, 加藤 量広, 柿坂 庸介, 藤川 真由, 中里 信和, 岩崎 真樹, 田中 章景

    臨床神経学　2015/01

  202. てんかん外科治療の適応精査で心理社会的評価が有用であった一例

    岸本 百合, 藤川 真由, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 神 一敬, 中里 信和

    てんかん研究　2015/01

  203. オランザピンにより発作後もうろう状態に伴う興奮が抑制できた二例

    岩城 弘隆, 岩佐 博人, 茂木 太一, 藤川 真由, 神 一敬, 中里 信和, 兼子 直

    てんかん研究　2015/01

  204. 脳磁図のみで発作活動が記録された外傷性てんかんの一例

    石田 誠, 柿坂 庸介, 神 一敬, 岩崎 真樹, 菅野 彰剛, 加藤 量広, 川島 隆太, 中里 信和

    てんかん研究　2015/01

  205. てんかんは日本人における睡眠呼吸障害の危険因子とはならない

    加藤 量広, 神 一敬, 中村 美輝, 横田 恵理, 岩崎 真樹, 柿坂 庸介, 青木 正志, 中里 信和

    臨床神経学　2014/12

  206. ビデオ脳波モニタリング中に心静止を来した神経調節性失神・房室ブロックの1例

    加藤 量広, 神 一敬, 柿坂 庸介, 中村 美輝, 鈴木 菜摘, 藤川 真由, 中里 信和, 岩崎 真樹, 青木 正志

    臨床神経学　2014/11

  207. 体性感覚前兆の診断にビデオ脳波モニタリングが有用であった左中心溝底部皮質形成異常の1例

    秋山 徹也, 神 一敬, 柿坂 庸介, 加藤 量広, 藤川 真由, 岩崎 真樹, 青木 正志, 中里 信和

    臨床神経学　2014/11

  208. 側頭葉てんかんの発作時脳波と脳画像所見

    板橋 泉, 神 一敬, 岩崎 真樹, 北澤 悠, 加藤 量広, 柿坂 庸介, 中里 信和

    臨床神経生理学　2014/10

  209. 長時間ビデオ脳波モニタリングでsubclinical rhythmic electroencephalographic discharges of adultsを認めた高齢てんかん患者3例

    横田 恵理, 櫻庭 理絵, 神 一敬, 北澤 悠, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 中里 信和

    臨床神経生理学　2014/10

  210. てんかん治癒例における術前脳磁図

    石田 誠, 岩崎 真樹, 神 一敬, 柿坂 庸介, 加藤 量広, 菅野 彰剛, 川島 隆太, 中里 信和

    臨床神経生理学　2014/10

  211. 睡眠ステージがhigh frequency oscillationsの出現に与える影響は海馬と新皮質で異なる

    岩崎 真樹, 櫻庭 理絵, 奥村 栄一, 神 一敬, 柿坂 庸介, 加藤 量広, 中里 信和, 冨永 悌二

    臨床神経生理学　2014/10

  212. REM睡眠期に高頻度に出現するhigh frequency oscillationsはてんかん原性領域に特異的である

    櫻庭 理絵, 岩崎 真樹, 奥村 栄一, 神 一敬, 柿坂 庸介, 加藤 量広, 冨永 悌二, 中里 信和

    臨床神経生理学　2014/10

  213. 問題症例の脳波 「心臓がドキッ」とし熱感および尿意を訴える自閉症スペクトラムと診断されている男児例

    柿坂 庸介, 神 一敬, 加藤 量広, 藤川 真由, 岩崎 真樹, 板橋 尚, 中里 信和

    臨床神経生理学　2014/10

  214. 小児てんかん外科領域における臨床神経生理学 小児期発症てんかんの外科治療適応を考える 神経内科の立場から

    神 一敬

    臨床神経生理学　2014/10

  215. Levetiracetamにより精神運動興奮を呈した交代性精神病に対しolanzapineが著効した2例

    岩城 弘隆, 山本 達也, 茂木 太一, 神 一敬, 中里 信和, 兼子 直

    てんかん研究　2014/09

  216. 左右半球に独立性の発作起始を認めるてんかん患者における発作時心拍変化

    加藤 量広, 神 一敬, 柿坂 庸介, 北澤 悠, 岩崎 真樹, 青木 正志, 中里 信和

    てんかん研究　2014/09

  217. てんかん患者における覚醒時とNREM睡眠時の心拍変動の比較

    鈴木 菜摘, 神 一敬, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 中里 信和

    てんかん研究　2014/09

  218. 高齢者てんかんにおける長時間ビデオ脳波モニタリング

    北澤 悠, 神 一敬, 加藤 量広, 柿坂 庸介, 藤川 真由, 岩崎 真樹, 田中 章景, 中里 信和

    てんかん研究　2014/09

  219. REM睡眠中にてんかん発作が記録された側頭葉外てんかん3例

    中村 美輝, 神 一敬, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 中里 信和

    てんかん研究　2014/09

  220. てんかんモニタリングユニットにおける転倒・転落

    竹田 希, 矢切 恵美子, 荒井 宏美, 小野 敬則, 及川 佳緒里, 原子 夏美, 鈴木 春美, 山内 かず子, 加藤 量広, 藤川 真由, 柿坂 庸介, 岩崎 真樹, 神 一敬, 中里 信和

    てんかん研究　2014/09

  221. 小児難治てんかんに対する一期的全脳梁離断術の発作予後および発達予後

    岩崎 真樹, 植松 貢, 中山 東城, 福與 なおみ, 大沢 伸一郎, 下田 由輝, 神 一敬, 萩野谷 和裕, 中里 信和, 冨永 悌二

    てんかん研究　2014/09

  222. てんかん発作と不随意運動発作をめぐって 睡眠時の非てんかん性不随意運動とてんかん発作

    神 一敬

    てんかん研究　2014/09

  223. てんかんと睡眠 成人てんかんにおける睡眠の影響

    神 一敬

    てんかん研究　2014/09

  224. REM睡眠中に左眼窩前頭皮質起始の過運動発作が記録された難治てんかんの一例

    加藤 量広, 神 一敬, 中村 美輝, 柿坂 庸介, 岩崎 真樹, 中里 信和

    日本睡眠学会定期学術集会プログラム・抄録集　2014/07

  225. 側頭葉てんかん発作焦点の側方性が睡眠構築に及ぼす影響

    中村 美輝, 神 一敬, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 中里 信和

    日本睡眠学会定期学術集会プログラム・抄録集　2014/07

  226. 若年てんかん患者におけるノンレムパラソムニアの合併

    神 一敬, 中村 美輝, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 中里 信和

    日本睡眠学会定期学術集会プログラム・抄録集　2014/07

  227. 側方徴候を呈した難治性若年ミオクロニーてんかんの1例

    小野 洋也, 加藤 量広, 神 一敬, 柿坂 庸介, 中里 信和, 岩崎 真樹, 青木 正志

    臨床神経学　2014/03

  228. てんかん外科におけるMEG言語マッピング

    岩崎真樹, 菅野彰剛, 神一敬, 中里信和, 川島隆太, 冨永悌二

    日本ヒト脳機能マッピング学会プログラム・抄録集　2014

  229. 小児難治てんかんに対する全脳梁離断術の発作および発達予後

    岩崎真樹, 植松貢, 中山東城, 福與なおみ, 大沢伸一郎, 下田由輝, 神一敬, 萩野谷和裕, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　2014/01

  230. Postictal generalized EEG suppression(PGES)の予測因子

    神 一敬, 板橋 尚, 加藤 量広, 岩崎 真樹, 中里 信和

    臨床神経学　2013/12

  231. 抗GAD抗体陽性側頭葉てんかんの臨床的特徴

    赤石 哲也, 神 一敬, 加藤 量広, 板橋 尚, 高木 正仁, 三須 建郎, 竪山 真規, 岩崎 真樹, 青木 正志, 中里 信和

    臨床神経学　2013/12

  232. 内側側頭葉てんかん患者における発作時心拍・心拍変動

    加藤 量広, 神 一敬, 板橋 尚, 岩崎 真樹, 青木 正志, 中里 信和

    臨床神経学　2013/12

  233. 健忘を主徴とした左側頭葉てんかんの1症例 日記と神経心理検査による術前後の機能変化の評価

    遠藤 佳子, 西尾 慶之, 岩崎 真樹, 神 一敬, 中里 信和, 森 悦朗

    神経心理学　2013/12

  234. てんかん患者に発作時脳磁図検査は有用である

    伊藤 進, アレクサポーロス・アンドレアス, 柿坂 庸介, 神 一敬, ワン・ゾン, モッシェー・ジョン, バージェス・リチャード

    臨床神経生理学　2013/10

  235. 脳梁離断術中の頭皮脳波半球間コヒーレンスモニタリング

    奥村 栄一, 岩崎 真樹, 櫻庭 理絵, 板橋 泉, 大沢 伸一郎, 神 一敬, 冨永 悌二, 中里 信和

    臨床神経生理学　2013/10

  236. 長時間ビデオ脳波モニタリングにより確認されたノンレムパラソムニア 若年てんかん患者6例の報告

    中村 美輝, 神 一敬, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 中里 信和

    臨床神経生理学　2013/10

  237. てんかんと睡眠 その密接な関連性 てんかんとパラソムニア てんかん学の視点から

    神 一敬

    臨床神経生理学　2013/10

  238. 頭蓋内電極による脳機能検査の新展開 高域ガンマ活動に着目した認知機能マッピング

    岩崎 真樹, 丹治 和世, 川口 典彦, 大沢 伸一郎, 西尾 慶之, 下田 由輝, 奥村 栄一, 鈴木 匡子, 神 一敬, 中里 信和, 冨永 悌二

    臨床神経生理学　2013/10

  239. 脳磁図棘波の信号源推定を用いた外傷性てんかんの診断

    板橋 泉, 神 一敬, 岩崎 真樹, 加藤 量広, 板橋 尚, 菅野 彰剛, 冨永 悌二, 川島 隆太, 中里 信和

    てんかん研究　2013/09

  240. 睡眠ステージによる高周波振動の分布の違い 側頭葉てんかん2例における検討

    櫻庭 理絵, 岩崎 真樹, 奥村 栄一, 神 一敬, 柿坂 庸介, 加藤 量広, 冨永 悌二, 中里 信和

    てんかん研究　2013/09

  241. てんかん発作日誌アプリ「Epi Diary」開発の経緯と今後の展開

    小出 泰道, 山内 俊雄, 松浦 雅人, 神 一敬, 漆畑 眞人, 斎藤 里加子, 鶴井 啓司, 堀口 香都, 島本 真規

    てんかん研究　2013/09

  242. 側頭葉てんかんの発作側方性と発作時心拍変化

    加藤 量広, 神 一敬, 柿坂 庸介, 岩崎 真樹, 青木 正志, 中里 信和

    てんかん研究　2013/09

  243. 半球間裂アプローチによる大脳半球離断術

    岩崎 真樹, 大沢 伸一郎, 下田 由輝, 植松 貢, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　2013/09

  244. Postictal generalized EEG suppressionを認めるてんかん患者の臨床的特徴

    神 一敬, 加藤 量広, 板橋 尚, 柿坂 庸介, 岩崎 真樹, 中里 信和

    てんかん研究　2013/09

  245. 50歳代で外科治療を行った側頭葉てんかん症例

    岩崎 真樹, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　2013/09

  246. てんかんのボーダーランド Sudden Unexpected Death in Epilepsy(SUDEP)の病態・機序解明に向けて

    神 一敬

    てんかん研究　2013/09

  247. 潜在発作のビデオ脳波記録が認知症との鑑別に有用であった高齢発症側頭葉てんかんの一例

    西山 亜由美, 神 一敬, 加藤 量広, 板橋 尚, 飯塚 統, 岩崎 真樹, 青木 正志, 中里 信和

    臨床神経学　2013/09

  248. てんかん発作と非てんかん性不随意運動の鑑別に苦慮した抗NMDA受容体脳炎の一例

    吉田 隼, 加藤 量広, 神 一敬, 板橋 尚, 中里 信和, 岩崎 真樹, 黒澤 和大, 大嶋 龍司, 向井 由幸, 西山 修平, 竪山 真規, 青木 正志

    臨床神経学　2013/09

  249. 健忘を主徴とした左側頭葉てんかんの1症例 日記と神経心理検査による術前後の機能変化の評価

    遠藤 佳子, 西尾 慶之, 岩崎 真樹, 神 一敬, 中里 信和, 森 悦朗

    日本神経心理学会総会プログラム・予稿集　2013/08

  250. 右上肢自動症・左上肢ジストニア肢位を呈した左側頭葉てんかんの一例

    加藤 量広, 神 一敬, 向井 由幸, 板橋 尚, 中里 信和, 岩崎 真樹, 青木 正志

    臨床神経学　2013/03

  251. 発作時徐脈を呈した側頭葉てんかんの3例

    向井 由幸, 加藤 量広, 神 一敬, 板橋 尚, 中里 信和, 岩崎 真樹, 青木 正志

    臨床神経学　2013/03

  252. Management of epilepsy monitoring unit and referral pattern of patients

    中里 信和, 神 一敬, 岩崎 真樹

    てんかん研究 = Journal of the Japan Epilepsy Society　2013/01/31

  253. Intra-operative Monitoring of Inter-hemispheric EEG Connectivity During Corpus Callosotomy

    Iwasaki Masaki, Okumura Eiichi, Sakuraba Rie, Itabashi Izumi, Osawa Shin-ichiro, Jin Kazutaka, Nakasato Nobukazu, Tominaga Teiji

    STEREOTACTIC AND FUNCTIONAL NEUROSURGERY　2013

  254. 小さな大脳皮質形成異常の診断における脳波と脳磁図の有用性

    中里信和, 板橋尚, 神一敬, 岩崎真樹, 菅野彰剛

    日本ヒト脳機能マッピング学会プログラム・抄録集　2013

  255. ビデオ脳波モニタリングユニット運営における患者のフロー・マネージメント

    中里 信和, 神 一敬, 岩崎 真樹

    てんかん研究　2013/01

  256. 難治てんかん重積に対するLevetiracetam大量経管投与

    加藤 量広, 神 一敬, 板橋 尚, 岩崎 真樹, 新妻 邦泰, 増山 祥二, 金子 仁彦, 菊池 昭夫, 小川 諒, 成川 孝一, 鈴木 靖士, 青木 正志, 中里 信和

    臨床神経学　2012/12

  257. 東日本大震災直後のてんかん患者の実態調査

    神 一敬, 加藤 量広, 板橋 尚, 大沢 伸一郎, 岩崎 真樹, 曾我 孝志, 中村 正三, 海野 美千代, 大堀 守一, 冨永 悌二, 中里 信和

    臨床神経学　2012/12

  258. 横双極モンタージュが棘波検出に有用であった2例

    伊澤 理香子, 神 一敬, 岩崎 真樹, 加藤 量広, 板橋 尚, 菅野 彰剛, 中里 信和

    臨床神経生理学　2012/10

  259. 全般性強直間代発作に伴うPostictal generalized electroencephalographic suppression(PGES)

    板橋 尚, 神 一敬, 岩崎 真樹, 加藤 量広, 中里 信和

    臨床神経生理学　2012/10

  260. 棘波検出ソフトウェア補助による新人脳波技師と認定医の判読結果の比較

    板橋 泉, 岩崎 真樹, 神 一敬, 櫻庭 理絵, 加藤 量広, 板橋 尚, 中里 信和

    臨床神経生理学　2012/10

  261. 棘波検出ソフトウェアによる長時間脳波判読の効率化

    櫻庭 理絵, 岩崎 真樹, 神 一敬, 板橋 泉, 加藤 量広, 板橋 尚, 中里 信和

    臨床神経生理学　2012/10

  262. 両側側頭葉てんかん患者における発作時無呼吸・心拍変化の検討

    加藤 量広, 神 一敬, 板橋 尚, 岩崎 真樹, 青木 正志, 中里 信和

    てんかん研究　2012/09

  263. テレビ会議システムを用いた遠隔てんかん専門外来の試み(第一報)

    神 一敬, 成田 徳雄, 板橋 尚, 加藤 量広, 岩崎 真樹, 中里 信和

    てんかん研究　2012/09

  264. 前頭頭頂部前頭葉てんかんにおける脳磁図(Magnetoencephalography in Fronto-Parietal Opercular Epilepsy)

    Kakisaka Yosuke, 岩崎 真樹, 神 一敬, 江夏 怜, Burgess Richard, 呉 繁夫, 中里 信和

    てんかん研究　2012/09

  265. MRI病変と脳磁図の棘波信号源推定が乖離した皮質形成異常の一例(A case of small cortical dysplasia showing a discrepancy in the location between MRI lesion and MEG spike sources)

    板橋 尚, 岩崎 真樹, 神 一敬, 加藤 量広, 菅野 彰剛, 中里 信和

    てんかん研究　2012/09

  266. 成人の発作、頭蓋内脳波

    神 一敬

    てんかん研究　2012/09

  267. Ictal central apneaを認めた家族性側頭葉てんかんの一例

    加藤 量広, 板橋 尚, 神 一敬, 岩崎 真樹, 中里 信和, 青木 正志

    臨床神経学　2012/07

  268. 右中心前回底部皮質形成異常に伴う難治性てんかんの一例

    板橋 尚, 神 一敬, 中里 信和, 岩崎 真樹, 大沢 伸一郎, 冨永 悌二

    てんかん研究　2012/06

  269. 脳梁離断術によって発作消失と発達改善が得られたWest症候群後難治てんかんの1例

    岩崎 真樹, 冨永 悌二, 植松 貢, 中山 東城, 佐藤 優子, 白石 秀明, 神 一敬, 中里 信和

    てんかん研究　2012/06

  270. 小児てんかん外科 早期手術患者の発見と利点 小児難治てんかんに対する脳梁離断術 長期発作寛解例の特徴

    岩崎 真樹, 植松 貢, 佐藤 優子, 中山 東城, 小林 朋子, 福與 なおみ, 萩野谷 和裕, 神 一敬, 大沢 伸一郎, 板橋 尚, 中里 信和, 冨永 悌二

    脳と発達　2012/05

  271. 脳梁離断術後の長期発作消失

    岩崎真樹, 植松貢, 佐藤優子, 中山東城, 小林朋子, 福與なおみ, 萩野谷和裕, 神一敬, 大沢伸一郎, 板橋尚, 中里信和, 冨永悌二

    第35回日本てんかん外科学会　2012/01/19

  272. Complete remission of seizures after corpus callosotomy International-presentation

    Masaki Iwasaki, Mitsugu Uematsu, Yuko Sato, Tojo Nakayama, Kazuhiro Haginoya, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    第65回アメリカてんかん学会（AES）　2011/12/02

  273. Survey on causes of death in epilepsy patients: search for risk factors of SUDEP in Japan International-presentation

    Kazutaka Jin, Takashi Soga, Shozo Nakamura, Michiyo Unno, Morikazu Ohori, Masaki Iwasaki, Nobukazu Nakasato

    第65回アメリカてんかん学会（AES）　2011/12/02

  274. 海馬硬化を伴う側頭葉てんかんに対する外科治療後の残存・再発発作の特徴

    神 一敬, 岩崎 真樹, 大沢 伸一郎, 中里 信和, 冨永 悌二

    臨床神経学　2011/12

  275. てんかん発症が先行した抗GAD抗体陽性小脳失調症の2例

    三浦 永美子, 神 一敬, 菅野 重範, 長谷川 隆文, 竪山 真規, 武田 篤

    臨床神経学　2011/12

  276. 下肢の部分発作を主徴とする皮質形成異常の電磁気生理学

    板橋尚, 神一敬, 岩崎真樹, 菅野彰剛, 大沢伸一郎, 冨永悌二, 中里信和

    第41回日本臨床神経生理学会　2011/11/10

  277. MRI異常のない側頭葉てんかんの一手術例

    神一敬, 板橋尚, 岩崎真樹, 中里信和

    第41回日本臨床神経生理学会　2011/11/10

  278. EEG and MEG spikes in patients with leg sensori-motor seizures International-presentation

    Hisashi Itabashi, Kazutaka Jin, Masaki Iwasaki, Eiichi Okumura, Akitake Kanno, Shinichiro Osawa, Teiji Tominaga, Nobukazu Nakasato

    第3回国際臨床脳磁図学会(ISACM)　2011/11/03

  279. 脳梁離断術後の発作消失に係わる因子

    岩崎真樹, 植松貢, 佐藤優子, 中山東城, 小林朋子, 福與なおみ, 萩野谷和裕, 神一敬, 大沢伸一郎, 板橋尚, 中里信和, 冨永悌二

    第70回日本脳神経外科学会総会　2011/10/12

  280. 脳梁離断術後の発作消失

    岩崎真樹, 植松貢, 佐藤優子, 中山東城, 小林朋子, 福與なおみ, 萩野谷和裕, 神一敬, 大沢伸一郎, 板橋尚, 中里信和, 冨永悌二

    第45回日本てんかん学会　2011/10/06

  281. てんかん専門病院におけるてんかん患者の死因調査 -SUDEPの実態-

    神一敬, 曾我孝志, 中村正三, 海野美千代, 大堀守一, 岩崎真樹, 中里信和

    第45回日本てんかん学会　2011/10/06

  282. 感覚運動発作を呈したBottom of sulcus dysplasiaの3例

    板橋尚, 神一敬, 岩崎真樹, 大沢伸一郎, 冨永悌二, 中里信和

    第45回日本てんかん学会　2011/10/06

  283. 下肢の感覚運動発作を主徴とする皮質形成異常における脳磁図の有用性

    板橋 尚, 神 一敬, 岩崎 真樹, 奥村 栄一, 菅野 彰剛, 大沢 伸一郎, 冨永 悌二, 中里 信和

    臨床神経生理学　2011/10

  284. てんかん発作時ビデオ脳波に関する判読と症例検討会 MRI異常のない側頭葉てんかんの一手術例

    神 一敬, 板橋 尚, 岩崎 真樹, 中里 信和

    臨床神経生理学　2011/10

  285. 感覚運動発作を呈したbottom-of-sulcus dysplasiaの3例

    板橋 尚, 神 一敬, 岩崎 真樹, 大沢 伸一郎, 冨永 悌二, 中里 信和

    てんかん研究　2011/09

  286. てんかん専門病院におけるてんかん患者の死因調査 SUDEPの実態

    神 一敬, 曾我 孝志, 中村 正三, 海野 美千代, 大堀 守一, 岩崎 真樹, 中里 信和

    てんかん研究　2011/09

  287. 脳梁離断術後の発作消失

    岩崎 真樹, 植松 貢, 佐藤 優子, 中山 東城, 小林 朋子, 福與 なおみ, 萩野谷 和裕, 神 一敬, 大沢 伸一郎, 板橋 尚, 中里 信和, 冨永 悌二

    てんかん研究　2011/09

  288. 症例検討会 先生ならどうするか 対側脳波異常が目立った側頭葉てんかんの一手術例

    岩崎 真樹, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　2011/09

  289. 右中心前回底部皮質形成異常に伴う難治てんかんの一例

    板橋尚, 神一敬, 岩崎真樹, 大沢伸一郎, 冨永悌二, 中里信和

    第5回日本てんかん学会東北地方会　2011/07/09

  290. 脳梁離断術によって発作消失と発達改善が得られたWest症候群後難治てんかんの一例

    岩崎真樹, 植松貢, 中山東城, 佐藤優子, 白石秀明, 神一敬, 中里信和, 冨永悌二

    第5回日本てんかん学会東北地方会　2011/07/09

  291. 海馬硬化を伴う側頭葉てんかんに対する外科治療後の残存・再発発作の特徴

    神一敬, 岩崎真樹, 大沢伸一郎, 中里信和, 冨永悌二

    第52回日本神経学会学術大会　2011/05/18

  292. てんかん発症が先行した抗GAD抗体陽性小脳失調症の2例

    三浦永美子, 神一敬, 菅野重範, 長谷川隆文, 竪山真規, 武田篤

    第52回日本神経学会学術大会　2011/05/18

  293. 内側側頭葉てんかんに対する外科治療の長期発作予後

    神 一敬, 岩崎 真樹, 大沢 伸一郎, 中里 信和, 冨永 悌二

    臨床神経学　2011/02

  294. 海馬硬化に伴う側頭葉てんかんの外科治療：再発例の特徴

    神一敬, 岩崎真樹, 大沢伸一郎, 中里信和, 冨永悌二

    第34回日本てんかん外科学会　2011/01/20

  295. 新皮質てんかん手術予後不良例の臨床的検討

    岩崎真樹, 神一敬, 大沢伸一郎, 中里信和, 冨永悌二

    第34回日本てんかん外科学会　2011/01/20

  296. 側頭葉てんかんに対する外科治療の長期発作予後について

    岩崎 真樹, 神 一敬, 大沢 伸一郎, 中里 信和, 冨永 悌二

    てんかん研究　2011/01

  297. てんかんで発症した多発性硬化症の1例

    加藤 量広, 井泉 瑠美子, 菅野 直人, 神 一敬, 中島 一郎, 藤原 一男

    てんかん研究　2011/01

  298. Which spikes are visible on MEG? – Three case reports of simultaneous recordings of interictal epileptiform discharges by MEG and invasive stereo-EEG International-presentation

    Kazutaka Jin, Andreas V. Alexopoulos, Jorge A. Gonzalez-Martinez, Juan Bulacio, Richard C. Burgess, John C. Mosher, Imad M. Najm

    64nd Annual Meeting of American Epilepsy Society　2010/12/03

  299. MEG Aids Interpretation of Epileptic Activity Propagation where Invasive Electrode Sampling is Inadequate International-presentation

    Irene Z. Wang, John C. Mosher, Richard C. Burgess, Kazutaka Jin, Yosuke Kakisaka, Imad M. Najm, Andreas V. Alexopoulos

    64nd Annual Meeting of American Epilepsy Society　2010/12/03

  300. MEG知見と頭蓋内脳波(ICEEG)知見の比較(Comparison between MEG and intracranial electroencephalogram (ICEEG) findings)

    神 一敬, Alexopoulos Andreas, Bulacio Juan, Mosher John, Burgess Richard

    臨床神経学　2010/12

  301. 東北大学病院てんかんモニタリングユニットの運用事例紹介

    神一敬, 岩崎真樹, 中里信和

    第27回日本脳電磁図トポグラフィ研究会　2010/11/18

  302. 長時間記録脳波の判読支援ソフトウェア：BESA-Epilepsyの有用性

    岩崎真樹, 神一敬, 菅野彰剛, Michael Scherg, 中里信和

    第27回日本脳電磁図トポグラフィ研究会　2010/11/18

  303. 頭皮脳波における追加電極に関する提言

    菅野彰剛, 岩崎真樹, 神一敬, 中里信和, 川島隆太

    第27回日本脳電磁図トポグラフィ研究会　2010/11/18

  304. 音楽てんかんの一例 ―脳磁図と頭蓋内脳波の同時記録―

    Kazutaka Jin, Joanna Fong, Andreas V. Alexopoulos, Stephen Hantus, John, C. Mosher, Richard C. Burgess

    第41回日本臨床神経生理学会・学術大会　2010/11/01

  305. 脳磁図と侵襲的ステレオ脳波による発作間欠時てんかん性異常波の同時記録

    Kazutaka Jin, Andreas V. Alexopoulos, Jorge A. Gonzalez-Martinez, Richard, C. Burgess, John C. Mosher, Imad M. Najm

    第44回日本てんかん学会　2010/10/14

  306. 海馬硬化による側頭葉てんかんに対する外科治療の長期予後：治癒例の検討

    岩崎真樹, 神一敬, 大沢伸一郎, 中里信和, 冨永悌二

    第44回日本てんかん学会　2010/10/14

  307. 音楽てんかんの一例 脳磁図と頭蓋内脳波の同時記録

    神 一敬, フォン・ジョアンナ, アレクソポウロス・アンドレアス, ハントス・ステファン, モッシャー・ジョン, バージェス・リチャード

    臨床神経生理学　2010/10

  308. 内側側頭葉てんかんに対する外科治療の長期発作予後

    神 一敬, 岩崎真樹, 大沢伸一郎, 中里信和, 冨永悌二

    第86回日本神経学会東北地方会　2010/09/11

  309. 脳磁図と侵襲的ステレオ脳波による発作間欠時てんかん性異常波の同時記録(Simultaneous recordings of interictal epileptiform discharges by MEG and invasive stereo-EEG: preliminary results from three patients with pharmacoresistant epilepsy)

    神 一敬

    てんかん研究　2010/09

  310. 海馬硬化による側頭葉てんかんに対する外科治療の長期予後 治癒例の検討

    岩崎 真樹, 神 一敬, 大沢 伸一郎, 中里 信和, 冨永 悌二

    てんかん研究　2010/09

  311. てんかんで発症した多発性硬化症の一例

    加藤量広, 井泉瑠美子, 菅野直人, 神一敬, 中島一郎, 藤原一男

    第4回日本てんかん学会東北地方会　2010/07/17

  312. 側頭葉てんかんに対する外科治療の長期発作予後について

    岩崎真樹, 神一敬, 大沢伸一郎, 中里信和, 冨永悌二

    第4回日本てんかん学会東北地方会　2010/07/17

  313. Comparison between MEG and Intracranial Electroencephalogram (ICEEG) Findings

    Kazutaka Jin, MD, Andreas V. Alexopoulos, MD, MPH, Juan Bulacio, MD, John C. Mosher, PhD, Richard C. Burgess, MD, PhD

    第51回日本神経学会学術大会　2010/05/20

  314. MEG source localization of interictal epileptiform discharges in patients where EEG localization is difficult or impossible: A report of 4 cases with massive asymmetric brain abnormalities International-presentation

    Kazutaka Jin, Andreas V. Alexopoulos, John C. Mosher, nd Richard, C. Burgess

    AES2009　2009/12/04

  315. Concordance between Magnetoencephalography (MEG) and Intracranial electroencephalogram (ICEEG) findings International-presentation

    Juan Bulacio, Kazutaka Jin, Andreas V. Alexopoulos, Dileep R. Nair, Timothy O’Connor, Jorge A. Gonzalez-Martinez, William E. Bingaman, Richard C. Burgess, John C. Mosher, Imad M. Najm

    AES2009　2009/12/04

  316. 発症前長期にわたりAQP4抗体が陽性であったNMOの1例

    西山 修平, 伊藤 孝, 三須 建郎, 高橋 利幸, 菊池 昭夫, 鈴木 直輝, 神 一敬, 青木 正志, 藤原 一男, 糸山 泰人

    臨床神経学　2009/12

  317. Interictal and Ictal MEG Study of Two Patients with Somatosensory Evoked Reflex Epilepsy International-presentation

    Kazutaka Jin, Andreas V. Alexopoulos, Imad Najm, Dileep R. Nair, John C. Mosher, nd Richard, C. Burgess

    ISACM2009　2009/09/04

  318. 発症前長期にわたりAQP4抗体が陽性であったNMOの1例

    西山 修平, 伊藤 孝, 三須 建郎, 高橋 利幸, 菊池 昭夫, 鈴木 直輝, 神 一敬, 青木 正志, 藤原 一男, 糸山 泰人

    神経免疫学　2009/03

  319. Clinical application of spatiotemporal signal space separation (tSSS) method for neuromagnetic recordings of epilepsy patients International-presentation

    Kazutaka Jin, Andreas V. Alexopoulos, John C. Mocher, Richard C. Burgess

    AES2008　2008/12/05

  320. 頭部MRIで特徴的な異常信号を呈したてんかん重積の一例

    松本 有史, 志賀 裕正, 久永 欣哉, 木村 格, 川口 典彦, 遠藤 薫, 小林 理子, 神 一敬

    臨床神経学　2008/02

  321. 脳幹病変を認め神経Behcet病が疑われた女性例の臨床的検討

    西山 修平, 菊池 昭夫, 加藤 量広, 三須 建郎, 神 一敬, 志賀 裕正, 藤原 一男, 糸山 泰人

    臨床神経学　2008/02

  322. 下垂体機能不全を合併した家族性アミロイドポリニューロパチー(Val30Met TTR)の一例

    遠藤 薫, 川口 典彦, 小林 理子, 神 一敬, 竪山 真規, 藤原 一男, 糸山 泰人, 池田 修一

    臨床神経学　2008/02

  323. 神経梅毒の3例

    高野 里菜, 神 一敬, 志賀 裕正, 佐藤 滋, 糸山 泰人

    臨床神経学　2007/12

  324. 髄液タウ蛋白濃度はギラン・バレー症候群の予後因子として有用である

    神 一敬, 武田 篤, 志賀 裕正, 佐藤 滋, 大沼 歩, 野村 宏, 楠 進, 糸山 泰人

    臨床神経学　2007/12

  325. くも膜下出血を繰り返したChurg-Strauss syndromeの一例

    高野 里菜, 神 一敬, 志賀 裕正, 糸山 泰人, 齋藤 明久

    臨床神経学　2007/06

  326. 多系統萎縮症では気管切開術後に中枢型睡眠時呼吸障害が増悪する

    神 一敬, 小野寺 宏, 千田 圭二, 阿部 憲男, 大沼 歩, 糸山 泰人

    臨床神経学　2006/12

  327. 多系統神経変性疾患としての原発性側索硬化症

    久永 欣哉, 鈴木 博義, 飛田 宗重, 日沼 雄二, 神 一敬, 金原 禎子, 菅野 重範, 木村 格

    臨床神経学　2006/12

  328. 難治性てんかん外科治療の実態 当施設の現状と問題点

    野村 宏, 社本 博, 中里 信和, 大沼 歩, 神 一敬, 岩崎 真樹, 藤原 悟, 冨永 悌二

    臨床神経学　2006/12

  329. 両側海綿静脈洞症候群を呈したStr. anginosus敗血症の一例

    高野里菜, 神一敬, 中村起也, 志賀裕正, 糸山泰人

    第11回日本神経感染症学会　2006/10/13

  330. 肺腫瘍に対する放射線療法が神経症状進行抑制に有効だった抗Hu抗体陽性傍腫瘍性神経症候群の1例

    松本 有史, 菅野 重範, 菊池 昭夫, 小野寺 淳一, 久永 欣哉, 木村 格, 高野 里奈, 高樹 孝昌, 神 一敬

    臨床神経学　2006/10

  331. ステロイド治療導入後に急激な筋力低下をきたしたMADSAMの一例

    瀬川 春奈, 神 一敬, 志賀 裕正, 堅山 真規, 糸山 泰人

    臨床神経学　2006/10

  332. 両側海綿静脈洞症候群を呈したStr.anginosus敗血症の1例

    高野 里菜, 神 一敬, 志賀 裕正, 糸山 泰人, 中村 起也

    臨床神経学　2006/10

  333. 平山病診断におけるdynamic MEPの有用性

    志賀 裕正, 高樹 孝昌, 加藤 昌昭, 神 一敬, 宮澤 康一, 糸山 泰人

    臨床神経生理学　2006/10

  334. Primary lateral sclerosis with extrapyramidal lesions and pathological changes similar to motor neuron disease with dementia. International-presentation

    Suzuki H, Hisanaga K, Hinuma Y, Tobita M, Jin K, Tsuchiya K, Takei H, Mochizuki H, Iwasaki Y

    International Congress of Neuropathology　2006/09/10

  335. 両側海綿静脈洞症候群を呈したStr.anginosus敗血症の一例

    高野 里菜, 神 一敬, 中村 起也, 志賀 裕正, 糸山 泰人

    NEUROINFECTION　2006/09

  336. Neuromagnetic spike localization in perilesional, contralateral mirror, and ipsilateral remote areas in patients with cavernoma. International-presentation

    Jin K, Nakasato N, Shamoto H, Kanno A, Fujiwara S, Itoyama Y

    The 15th International Conference on Biomagnetism　2006/08/20

  337. てんかんを発症した海綿状血管腫症例における脳磁図所見

    神 一敬, 中里 信和, 社本 博, 菅野 彰剛, 糸山 泰人, 冨永 悌二

    てんかん研究　2006/08

  338. 多系統萎縮症では気管切開術後に中枢型睡眠時呼吸障害が増悪する

    神一敬, 小野寺宏, 千田圭二, 阿部憲男, 大沼歩, 糸山泰人

    第47回日本神経学会総会　2006/05/11

  339. 重症パーキンソン病では閉塞型睡眠時無呼吸症候群を合併し易い

    神 一敬, 小野寺 宏, 金原 禎子, 野村 宏, 阿部 憲男, 糸山 泰人

    臨床神経学　2005/12

  340. スピーチカニューレを使用してQOLが改善した多系統萎縮症例

    中村 起也, 神 一敬, 千田 圭二, 阿部 憲男

    臨床神経学　2005/06

  341. Parkinson病の高度易転倒性に対する下肢躯幹の筋力増強訓練の効果

    千田 圭二, 中村 起也, 神 一敬, 阿部 憲男, 藤田 博信, 三沢 亮

    神経治療学　2005/05

  342. 家族性髄膜アミロイドーシス(Asp18GlyTTR型)の兄弟例

    神 一敬, 佐藤 滋, 高橋 敏行, 野村 宏, 高瀬 貞夫, 伊達 紫, 中里 雅光, 冨永 悌二, 糸山 泰人, 池田 修一

    臨床神経学　2004/12

  343. パーキンソン病の突然死と睡眠時無呼吸

    小野寺 宏, 神 一敬, 大沼 歩, 高瀬 貞夫, 千田 圭二, 阿部 憲男, 糸山 泰人

    臨床神経学　2004/12

  344. パーキンソン病患者の日常生活における転倒の頻度

    千田 圭二, 神 一敬, 中村 起也, 阿部 憲男

    臨床神経学　2004/12

  345. 慢性呼吸不全からうっ血性心不全に至ったMuSK抗体陽性seronegative重症筋無力症の1例

    佐藤 滋, 神 一敬, 鈴木 靖士, 望月 るり子, 野村 宏, 高瀬 貞夫, 白石 一裕, 本村 政勝, 吉村 俊朗, 齋藤 龍史, 小野寺 宏, 糸山 泰人

    神経免疫学　2004/01

  346. 経口セフェム薬による薬剤性無菌性髄膜炎の1例

    神 一敬, 佐藤 滋, 野村 宏, 高瀬 貞夫, 糸山 泰人

    臨床神経学　2004/01

  347. 当神経内科における側頭葉てんかん患者の実態

    大沼 歩, 神 一敬, 野村 宏, 高瀬 貞夫

    臨床神経学　2003/12

  348. プリオン蛋白遺伝子codon180の点変異(V180I)を伴うCreutzfeldt-Jakob病(CJD)の臨床的特徴

    神 一敬, 志賀 裕正, 佐藤 信行, 千田 圭二, 今野 秀彦, 堂浦 克美, 北本 哲之, 糸山 泰人

    臨床神経学　2003/12

  349. γ-グロブリン大量静注療法後に再燃し,免疫吸着療法が奏効した劇症型Guillain-Barre症候群の1例

    神 一敬, 佐藤 滋, 大沼 歩, 野村 宏, 高瀬 貞夫, 楠 進

    神経治療学　2003/05

  350. 大量免疫グロブリン静注療法が著効したBickerstaff型脳幹脳炎の2例

    中村 正史, 佐藤 滋, 金原 禎子, 神 一敬, 望月 るり子, 大沼 歩, 野村 宏, 高瀬 貞夫, 菊池 昭夫

    臨床神経学　2003/04

  351. 大量免疫グロブリン静注療法(IVIG)後に再燃し,免疫吸着療法が奏効した劇症型ギラン・バレー症候群の1例

    神 一敬, 佐藤 滋, 金原 禎子, 中村 正史, 望月 るり子, 大沼 歩, 野村 宏, 高瀬 貞夫

    臨床神経学　2003/04

  352. 脊髄小脳変性症に対する経頭蓋磁気刺激療法中に認めた副作用

    志賀 裕正, 清水 洋, 宮澤 康一, 神 一敬, 青木 正志, 糸山 泰人

    臨床神経生理学　2003/04

  353. Propofol,midazolam併用療法による難治性てんかん重積状態の治療

    神 一敬, 長谷川 隆文, 永井 真貴子, 志賀 裕正, 武田 篤, 糸山 泰人

    臨床神経学　2002/12

  354. 頭頂-頸髄,頭頂-腰髄,頸髄-腰髄Central motor conduction time(CMCT)の検討

    宮澤 康一, 志賀 裕正, 糸山 泰人, 神 一敬, 清水 洋

    臨床神経学　2002/12

  355. SCA6に対する小脳磁気刺激療法Placebo control study

    清水 洋, 志賀 裕正, 宮澤 康一, 神 一敬, 糸山 泰人

    臨床神経学　2002/12

  356. 中脳病変による垂直注視異常を伴ったocular tilt reaction

    竹下 孝之, 中川 陽一, 玉井 信, 冨永 悌二, 神 一敬

    神経眼科　2002/10

  357. 特異なMRI所見を認めた成人重症麻疹脳炎の1例

    神 一敬, 齋藤 龍史, 佐藤 滋, 大沼 歩, 野村 宏, 高瀬 貞夫, 糸山 泰人

    臨床神経学　2002/07

  358. 家族性CJD(V180I)の頭部MRI所見

    瀬野 暢仁, 神 一敬, 長谷川 隆文, 松崎 理子, 武田 篤, 志賀 裕正, 糸山 泰人, 浅野 昌宏, 野村 宏, 千田 圭二, 大友 仁

    臨床神経学　2002/01

  359. パーキンソン病患者の末梢血にみられるCD4 bright+ CD8 dull+Tリンパ球の検討

    久永 欣哉, 浅黄 美沙, 神 一敬, 佐藤 信行, 糸山 泰人, 岩崎 祐三

    臨床神経学　2001/11

  360. SCDへの経頭蓋磁気刺激 sham and active stimulation

    松崎 理子, 志賀 裕正, 宮澤 康一, 清水 洋, 神 一敬, 津田 丈秀, 糸山 泰人

    臨床神経学　2001/11

  361. 磁気刺激はSCD患者に有効 placebo control study

    志賀 裕正, 清水 洋, 宮澤 康一, 松崎 理子, 神 一敬, 大沼 歩, 津田 丈秀, 糸山 泰人

    臨床神経学　2001/11

  362. 脊髄小脳変性症に対する経頭蓋磁気刺激療法 歩行解析による定量的な治療効果判定

    神 一敬, 志賀 裕正, 久永 欣哉, 高橋 博達, 清水 洋, 宮澤 康一, 望月 廣, 糸山 泰人

    神経治療学　2001/11

  363. Transcranial magnetic stimulation is useful to improve ataxic gait of spinocerebellar ataxia 6 patients

    H Shimizu, Y Shiga, K Jin, K Miyazawa, T Tsuda, Y Itoyama

    ANNALS OF NEUROLOGY　2001/09

  364. Quantitative analysis of therapeutic transcranial magnetic stimulation for spinocerebellar degeneration

    K Jin, Y Shiga, H Shimizu, H Takahashi, K Hisanaga, N Takahashi, H Mochizuki, Y Itoyama

    ANNALS OF NEUROLOGY　2001/09

  365. 両側前骨間神経症候群を呈したneuralgic amyotrophyの一例

    鈴木 直輝, 神 一敬, 志賀 裕正, 加藤 宏之, 糸山 泰人

    臨床神経学　2001/07

  366. テオフィリン脳症の一例

    渋谷 聡, 松本 有史, 神 一敬, 望月 廣, 岩崎 祐三

    臨床神経学　2001/04

  367. MRI FLAIR画像で広範な脳幹病変を呈した悪性リンパ腫の一例

    神 一敬, 深津 玲子, 久永 欣哉, 望月 廣, 岩崎 祐三, 渡辺 哲子, 金田 京子

    臨床神経学　2001/04

  368. Opsoclonus-myoclonus症候を呈した脳幹脳炎の一例

    佐藤 信行, 渋谷 聡, 神 一敬, 飛田 宗重, 望月 廣

    臨床神経学　2001/04

  369. 動作解析システムを用いた脊髄小脳変性症における失調性歩行の定量的評価

    神 一敬, 高橋 博達, 久永 欣哉, 望月 廣

    臨床神経生理学　2001/04

  370. 脊髄小脳変性症(SCD)への経頭蓋磁気刺激療法 疑似刺激効果と実刺激効果

    志賀 裕正, 清水 洋, 宮澤 康一, 神 一敬, 津田 丈秀, 糸山 泰人

    臨床神経生理学　2001/04

  371. 脊髄小脳変性症の脳波所見 磁気刺激療法例での検討

    大沼 歩, 高瀬 貞夫, 清水 洋, 神 一敬, 志賀 裕正

    臨床神経生理学　2001/04

  372. Actigraphyによるパーキンソン病定位脳手術の治療効果判定の試み

    神 一敬, 佐藤 信行, 久永 欣哉, 岩崎 祐三, 望月 廣, 安藤 肇史, 仁村 太郎

    臨床神経学　2000/12

  373. パーキンソン病患者の末梢血におけるCD4+CD8du11+Tリンパ球の増加

    久永 欣哉, 浅黄 美沙, 神 一敬, 佐藤 信行, 望月 廣, 岩崎 祐三, 糸山 泰人

    臨床神経学　2000/12

  374. レビー小体型痴呆の脳血流SPECT画像の検討 パーキンソン病との対比

    佐藤 信行, 神 一敬, 久永 欣哉, 望月 廣, 川島 隆太

    臨床神経学　2000/12

  375. 脊髄小脳変性症への磁気刺激療法 placebo control study

    宮澤 康一, 大沼 歩, 高瀬 貞夫, 清水 洋, 神 一敬, 望月 廣, 志賀 裕正, 津田 丈秀, 糸山 泰人

    臨床神経学　2000/09

  376. 小脳性歩行失調を呈したChurg-Strauss症候群の1例

    渋谷 聡, 神 一敬, 佐藤 信行, 飛田 宗重, 岩崎 祐三, 望月 廣

    臨床神経学　2000/09

  377. 小脳磁気刺激治療が有効であった遺伝性皮質性小脳萎縮症の1例 歩行解析による定量的な治療効果判定の試み

    神 一敬, 佐藤 信行, 久永 欣哉, 望月 廣, 高橋 博達, 志賀 裕正, 糸山 泰人, 清水 洋

    臨床神経学　2000/05

  378. Migraine Strokeと思われる1例

    松本 有史, 神 一敬, 粟飯原 直人, 塚本 哲朗

    臨床神経学　2000/01

  379. Actigraphyによるパーキンソン病患者の活動量の定量的検討

    神 一敬, 古沢 義人, 佐藤 信行, 久永 欣哉, 望月 廣, 安藤 肇史, 岩崎 祐三

    臨床神経学　2000/01

  380. 延髄梗塞にて発症した内頸動脈狭窄を伴ったPersistent primitive hypoglossal artery(PPHA)の1例

    神 一敬, 粟飯原 直人, 塚本 哲朗

    臨床神経学　2000/01

  381. Dementia with Lewy bodiesの臨床的検討

    神 一敬

    臨床神経学　1998/04

  382. 亜急性に発症し嗜眠症状,Parkinsonismを呈した脳症の1剖検例

    神 一敬

    臨床神経学　1997/11

  383. 脳梁の菲薄化を伴った痙性対麻痺の母子例

    神 一敬

    臨床神経学　1997/05

  384. ホジキン病の放射線治療に発症した単純ヘルペス脳炎の一例

    神 一敬

    臨床神経学　1996/10

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Research Projects 9

  1. てんかんに特化した遺伝子パネル及び薬剤選択支援AIの開発

    神一敬

    Offer Organization: 科学技術振興機構

    System: みちのくGAPファンド (ステップ2通常枠)

    2025/04 - 2028/03

  2. Visualization of dynamic brain function by magnetoencephalography using tunnel magnetic resistance (TMR) sensors

    Nakasato Nobukazu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    In the present study, we successfully measured magnetocardiography (MCG) using tunnel-magnetic-resistance (TMR) sensors without signal averaging technique. We also successfully measured magnetoencephalography (MEG) using TMR sensors for the first. In order to expand MEG application, we applied conventional SQUID MEG to reveal neuronal mechanism of “lip-reading”. We also applied MEG to measure somatosensory evoked magnetic fields (SEFs) with strict separation of awake and sleep condition. As a result, we found amplitude of N20m, the first component of SEFs, is decreased during awake condition only in patients with temporal lobe epilepsy. Using intracranial electrode, we also found high frequency oscillation during rapid-eye-movement (REM) sleep is specific to epileptogenic area. Above all results, we became more confident for the development of TMR MEG system in the future.

  3. 多面的自律神経モニタリングを用いたてんかん発作惹起の機序解明 Competitive

    神 一敬

    Offer Organization: 日本学術振興会

    System: 科学研究費補助金（基盤研究 (C)（一般））

    2016/04 - 2019/03

  4. Toward understanding the neural network abnormalities in cognitive impairment and neuropsychiatric symptoms in epilepsy

    Nishio Yoshiyuki, Hiroaki Hosokawa

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    1. We constructed a health-related QOL model for 150 patients with temporal lobe epilepsy. Higher self-perception of cognitive impairment, lower social function and higher seizure worries were the primary predictors of overall QOL. 2. We investigated face perception abilities in post-surgical patients with left and right anterior lobectomy (ATL) for treatment of drug-resistant temporal lobe epilepsy. Patients with left ATL performed equivalently on the perceptual tasks for front, oblique and noise-masked face images, whereas patients with right ATL performed worse on oblique and noise-masked images compared with on front face images. 3. We published a case series study of confabulation in patients with frontal lobe epilepsy.

  5. Epileptic seizure prediction system using wearable HRV sensor

    Miho Miyajima, KANO Manabu, MATSUURA Masato, MAEHARA Taketoshi, INAJI Motoki, SASANO Tetsuo, WATANABE Satsuki, SAKUMA Taeko, JIN Kazutaka, NAKAZATO Nobukazu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tokyo Medical and Dental University

    2013/04/01 - 2017/03/31

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    Patients with intractable epilepsy suffer from accidents and injuries associated with epileptic seizures. To prevent the seizure-associated accidents and improve quality of life (QOL) of epileptic patients, the present work proposes a new real-time epileptic seizure prediction and alert system employing a wearable heart rate variability (HRV) telemeter and a smartphone. The R-R interval (RRI) data is stored into a smartphone via a Bluetooth wireless transmission. The smartphone application for epileptic seizure prediction detect peri-ictal status based on multivariate statistical process control (MSPC) for the HRV data and alert the patients and the caregivers to the seizure. The HRV-based seizure prediction algorithm demonstrated sensitivity of 91% for partial seizures, that is, competitive performance with electroencephalography (EEG)-based methods. The possibility of realizing a HRV-based epileptic seizure prediction system with high wearability was shown.

  6. てんかん難治化における睡眠構築の異常と自律神経障害の影響 Competitive

    神 一敬

    Offer Organization: 日本学術振興会

    System: 科学研究費補助金（基盤研究 (C)（一般））

    2013/04 - 2016/03

  7. Development of pediatric MEG measurement without sedation

    NAKASATO Nobukazu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2013/04/01 - 2015/03/31

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    We applied superconducting quantum interference device (SQUID)-based magnetoencephalography (MEG) to measure both normal brain function and epilepsy-related abnormal activity for future development of tunnel-magnetic-registance (TMR)-based high resolution MEG system. Subjects were people with epilepsy with focal cortical dysplasia, with various types of age-dependent epilepsy, or with interhemispheric foci; and normal subjects. Time-axis waveformes and sensor-based isofield maps were analyzed for both epileptic and normal auditory function. These basic data can be used to apply future development of high-resolution MEG system using TMR sensors.

  8. Neural network scale involved in genesis of hippocampal seizures

    NAKASATO Nobukazu, JIN Kazutaka, IWASAKI Masaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2011 - 2012

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    This study was aimed to investigate neural network dynamics involved in the genesis of epileptic seizures. We used optogenetically induced model of hippocampal seizures. Multi-contact local field potentials were recorded during induction of hippocampal seizures and the information flow was analyzed statistically. Granger causality analysis revealed importance of information flow along longitudinal hippocampal axis during genesis of epileptic seizures.

  9. Central sleep apnea and sudden unexpected death in epilepsy (SUDEP)in patients with intractable epilepsy Competitive

    JIN Kazutaka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2011 - 2012

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    No epilepsy patients revealed significant central sleep apneas. A patient with bilateral temporal lobe epilepsy showed that central apneas precede ictal EEG onset in seizures arising from left temporal region and follow it in those arising from right. In addition, seizures arising from left and right temporal regions had different patterns of heart rate changes from each other. Ictal central apnea and heart rate changes would be closely associated with seizure lateralization.

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Media Coverage 4

  1. 知って安心てんかん Myself

    Date FM（FM仙台）　Morning Brush（モーニングブラッシュ）

    2025/03/14

    Type: TV or radio program

  2. 知って安心てんかん Myself

    Date FM（FM仙台）　Morning Brush（モーニングブラッシュ）

    2024/03/22

    Type: TV or radio program

  3. 気になる症状 すっきり診断「てんかんの正しい理解を」 Myself

    河北新報社　河北新報

    2019/06/21

    Type: Newspaper, magazine

  4. [日本国内] 知って安心身近な病気てんかん

    Date FM（FM仙台）

    2011/06/07

    Type: TV or radio program

    More details Close

    Date FMのラジオ番組にゲスト出演。