Details of the Researcher

PHOTO

Yoko Kobayashi
Section
Tohoku University Hospital
Job title
Senior Assistant Professor
Degree

  • 博士（歯学）（東北大学）

Research History 5

  • 2021/04 - Present
    Tohoku University Hospital　Dental Safety and System Management　Deputy Director

  • 2020/04 - 2021/03
    Tohoku University Hospital　Dental Hospital Infection Control

  • 2002/01 - 2020/03
    Tohoku University　Graduate School of Dentistry　Assistant Professor

  • 2000/10 - 2001/12
    State University of New York at Buffalo

  • 1995/04 - 2000/09
    Tohoku University　Department of Dentistry　Assistant Professor

Education 2

  • Tohoku University　Graduate School, Division of Dental Research

    - 1994/03

  • Tohoku University　Faculty of Dentistry

    - 1990/03

Committee Memberships 1

  • 日本歯科保存学会　評議員

    2017/04 - 2019/03

Professional Memberships 10

  • 日本歯科医療管理学会

    2024/10 - Present

  • 日本口腔感染症学会

    2020/04 - Present

  • 日本医療安全学会

    2019/04 - Present

  • 日本感染症学会

    2019/04 - Present

  • 医療の質・安全学会

    2018/04 - Present

  • 日本環境感染学会

    2018/04 - Present

  • JAPANESE DENTAL EDUCATION ASSOCIATION

    2016/04 - Present

  • International Association for Dental Research

    1999/01 - Present

  • JAPANESE ASSOCIATION FOR DENTAL RESEARCH

    1999/01 - Present

  • THE JAPANESE SOCIETY OF CONSERVATIVE DENTISTRY

    1990/04 - Present

︎Show all ︎Show first 5

Research Interests 2

  • dental safety and system management

  • Medical Safety

Research Areas 3

  • Life sciences / Healthcare management, medical sociology /

  • Life sciences / Community dentistry /

  • Life sciences / Conservative dentistry and endodontics /

Awards 1

  1. Dentsply award

    2003　The Japanese Society of Concervative Dentistry

Papers 45

  1. Reduction of aerosol and droplet dispersions using intraoral and extraoral vacuums for dental treatments with face-up, diagonal and upright positions

    Tomonari Kajita, Kenji Kikuchi, Hiromitsu Morishima, Jun Watanabe, Yoko Iwamatsu-Kobayashi, Hiroyasu Kanetaka, Wataru Yashiro, Kensuke Yamauchi, Hiroshi Egusa

    BMC Oral Health　24　(1)　2024/11/17

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12903-024-04911-5 　

    eISSN： 1472-6831

  2. 超音波スケーラーによる飛沫エアロゾルの可視化と吸引装置による拡散抑制効果

    渡辺 隼, 小林 洋子, 江草 宏

    日本口腔内科学会雑誌　29　(2)　89-89　2023/12

    Publisher: (一社)日本口腔内科学会

    ISSN： 2186-6147

    eISSN： 2186-6155

  3. 東北大学病院歯科部門における過去16年間の誤飲・誤嚥インシデント

    小林 洋子, 倉内 美智子, 渡辺 隼, 草間 太郎, 菅原 寛子, 西條 文人, 田畑 雅央, 飯久保 正弘, 杉浦 剛, 江草 宏

    医療の質・安全学会誌　18　(Suppl.)　352-352　2023/11

    Publisher: (一社)医療の質・安全学会

    ISSN： 1881-3658

    eISSN： 1882-3254

  4. 歯科用エアータービンにより発生する飛沫エアロゾル挙動の可視化と吸引装置の有効性

    渡辺 隼, 小林 洋子, 江草 宏

    日本補綴歯科学会誌　15　(特別号)　241-241　2023/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  5. Visualization of droplets and aerosols in simulated dental treatments to clarify the effectiveness of oral suction devices

    Jun Watanabe, Yoko Iwamatsu-kobayashi, Kenji Kikuchi, Tomonari Kajita, Hiromitsu Morishima, Kensuke Yamauchi, Wataru Yashiro, Hidekazu Nishimura, Hiroyasu Kanetaka, Hiroshi Egusa

    Journal of Prosthodontic Research　2023

    Publisher: Japan Prosthodontic Society

    DOI： 10.2186/jpr.jpr_d_23_00013 　

    ISSN： 1883-1958

    eISSN： 1883-9207

  6. 東北大学病院歯科部門における過去15年間のインシデントレポート分析

    小林 洋子, 倉内 美智子, 渡辺 準, 草間 太郎, 遠藤 英昭, 菅原 寛子, 西條 文人, 田畑 雅央, 飯久保 正弘, 江草 宏

    医療の質・安全学会誌　17　(Suppl.)　290-290　2022/11

    Publisher: (一社)医療の質・安全学会

    ISSN： 1881-3658

    eISSN： 1882-3254

  7. COVID-19-Related Symptoms during the SARS-CoV-2 Omicron (B.1.1.529) Variant Surge in Japan.

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　258　(2)　103-110　2022/09/06

    DOI： 10.1620/tjem.2022.J067 　

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    The exact profiles of the clinical symptoms related to the SARS-CoV-2 Omicron variant (B.1.1.529) remain largely uncertain. Therefore, this study aimed to clarify the clinical manifestations of infection with this variant. We enrolled individuals who were tested by quantitative nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) test at a large screening center in a city of Japan during the B.1.1.529 Omicron variant wave between January and May 2022, after contact with COVID-19 patients. Swab tests were planned to be performed approximately 4-5 days after contact. The presence of COVID-19-related symptoms was assessed at the swab test site. Among the 2,507 enrolled individuals, 943 (37.6%) were RT-PCR test-positive and 1,564 (62.4%) were test-negative. Among the 943 PCR test-positive participants, the prevalence of the symptoms was as follows: 47.3% with cough, 32.9% with sore throat, 18.4% with fatigability, 12.7% with fever of ≥ 37.5℃, 9.9% with dyspnea, 2.1% with dysosmia, and 1.4% with dysgeusia. The prevalence of cough, sore throat, dyspnea, and fatigability was higher among adults aged ≥ 18 years than among children and adolescents. The prevalence of dysosmia and dysgeusia remarkably decreased during the Omicron wave (1-3%) compared to during the pre-Omicron variant waves (15-25%). In summary, common COVID-19-related symptoms during the Omicron variant wave included cough and sore throat, followed by fatigability, fever, and dyspnea. The prevalence of most of these symptoms was higher in adults than in non-adults. The prevalence of dysosmia and dysgeusia remarkably decreased with the Omicron variant than with pre-Omicron variants.

  8. Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan International-journal

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    Scientific Reports　12　(1)　13589-13589　2022/08/10

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-022-17990-7 　

    eISSN： 2045-2322

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    Abstract The administration of a third booster dose of messenger ribonucleic acid (mRNA) vaccines against coronavirus disease 2019 (COVID-19) has progressed worldwide. Since January 2022, Japan has faced a nationwide outbreak caused by the Omicron variant, which occurred simultaneously with the progression of mass vaccination with the third booster dose. Therefore, this study evaluated the effectiveness of the third dose of vaccine by reverse transcription-polymerase chain reaction (RT-PCR) test using nasopharyngeal swab samples from adults aged ≥ 18 years tested after having close contact with COVID-19 cases between January and May 2022. Participants who completed only one dose were excluded from the study. Among the 928 enrolled participants, 139 had never been vaccinated, 609 had completed two doses, 180 had completed three doses before the swab test, and the overall RT-PCR test positivity rate in each group was 48.9%, 46.0%, and 32.2%, respectively. The vaccine effectiveness of the third dose to prevent infection after close contact was approximately 40% (95% confidence interval: 20–60%), which was the highest at 10–70 days after receiving the third dose. In conclusion, the effectiveness of the three-dose mRNA COVID-19 vaccine after close contact during the Omicron outbreak is approximately 40%.

  9. A 19-Year Study of Dental Needlestick and Sharps Injuries in Japan Peer-reviewed

    Yoko Iwamatsu-Kobayashi, Jun Watanabe, Taro Kusama, Hideaki Endo, Shinobu Ikeda, Koichi Tokuda, Kaoru Igarashi, Hiroshi Egusa

    International Dental Journal　73　(1)　114-120　2022/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.identj.2022.04.009 　

    ISSN： 0020-6539

  10. 切削器具が及ぼす浮遊エアロゾルの可視化と口腔外バキュームの有用性について

    梶田 倫功, 山内 健介, 森島 浩允, 野上 晋之介, 渡辺 隼, 小林 洋子, 金高 弘恭, 高橋 哲

    東北大学歯学雑誌　39/40/41　(2/1-2/1)　52-52　2022/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  11. 歯科治療で発生するエアロゾル挙動の可視化

    小林 洋子, 渡辺 隼, 梶田 倫功, 山内 健介, 金高 弘恭, 江草 宏, 五十嵐 薫, 矢代 航, 菊地 謙次, 西村 秀一, 森島 浩允, 佐藤 舜, 菅井 優生

    東北大学歯学雑誌　39/40/41　(2/1-2/1)　49-49　2022/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  12. 切削器具が及ぼす浮遊エアロゾルの可視化と口腔外バキュームの有用性について

    梶田 倫功, 山内 健介, 森島 浩允, 野上 晋之介, 渡辺 隼, 小林 洋子, 金高 弘恭, 高橋 哲

    東北大学歯学雑誌　39/40/41　(2/1-2/1)　52-52　2022/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  13. Effectiveness of mRNA COVID-19 Vaccines in Japan during the Nationwide Pandemic of the Delta Variant. Peer-reviewed

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　257　(1)　1-6　2022/05/13

    DOI： 10.1620/tjem.2022.J012 　

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    The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remained a major global health concern in 2021. To suppress the spread of infection, mass vaccinations have been performed across countries worldwide. In Japan, vaccinations of the first and second doses for most of the nation were performed during the nationwide outbreak of the B.1.617.2 (Delta) variant with the L452R spike protein mutation, and the effectiveness of the vaccinations to suppress the spread of COVID-19 among the people in Japan remains uncertain. In this study, adults aged ≥18 years, who were in contact with patients with COVID-19 and underwent nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) tests during August and September 2021 at a mass screening test center in Japan, were enrolled. In this period, more than 95% of the COVID-19 infections were reportedly caused by the Delta variant. As a result, a total of 784 adults with recent contact history, including 231 (29.5%) RT-PCR test-positive cases, were enrolled. The test positivity rate was lower in individuals who had been vaccinated twice than in unvaccinated individuals (12.5% vs. 39.0%, p < 0.0001), with the risk ratio of 0.32 (95% confidence interval 0.23-0.46). The vaccine effectiveness was the highest between 7-90 days after the second vaccine dose. In conclusion, two doses of mRNA COVID-19 vaccines effectively suppressed transmission in Japan during the nationwide pandemic of the Delta variant, estimated to have prevented 50-80% of the infection.

  14. COVID-19 Transmission at Schools in Japan. Peer-reviewed

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　255　(3)　239-246　2021/11

    DOI： 10.1620/tjem.255.239 　

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    The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global public health concern in 2021. However, the risk of attending schools during the pandemic remains unevaluated. This study estimated the secondary transmission rate at schools using the results of a real-time reverse transcription-polymerase chain reaction (RT-PCR) screening test performed between July 2020 and April 2021, before starting the nationwide mass vaccination. A total of 1,924 students (20 RT-PCR-positive; 1.0%) from 52 schools or preschools were evaluated, together with 1,379 non-adults (95 RT-PCR-positive; 6.9%) exposed to SARS-CoV-2 in non-school environments. Assuming that the infectious index cases were asymptomatic and the transmission at schools followed a Bernoulli process, we estimated the probability of transmission after each contact at school as approximately 0.005 (0.5% per contact) with the current infection prevention measures at schools in Japan (i.e., hand hygiene, physical distancing, wearing masks, and effective ventilation). Furthermore, assuming that all children are capable of carrying the infection, then contact between an index case and 20-30 students per day at schools would yield the expected value for secondary cases of ≥ 1.0, during the 10 days of the infectious period. In conclusion, with the current infection prevention measures at schools in Japan, secondary transmission at schools would occur in approximately every 200 contacts. When considering this rate, compliance with the current infection prevention measures at schools and early detection and quarantine of the index cases would be effective in preventing the spread of COVID-19 at schools.

  15. Discriminatory Value of Self-reported Olfactory Dysfunction in the Prediction of Coronavirus Disease 2019 Peer-reviewed

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Junichi Tanaka, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    Internal Medicine　60　(18)　2905-2910　2021/09/15

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.7238-21 　

    ISSN： 0918-2918

    eISSN： 1349-7235

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    Objective Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), remains the world's largest public health concern in 2021. A history of close contact with infectious patients is a factor that predicts a positive SARS-CoV-2 test result. Meanwhile, the precise predictive value of symptoms suggestive of COVID-19 has not been fully elucidated. This study aimed to clarify the predictive and discriminatory value of each clinical symptom suggestive of COVID-19. Methods This study enrolled participants who were tested for SARS-CoV-2 by reverse transcription polymerase chain reaction using a nasopharyngeal swab between November 2020 and January 2021. All enrolled patients were evaluated for data regarding the presence and closeness of contact with infectious patients and comprehensive clinical features (i.e., fever, cough, dyspnea, fatigue, dysosmia, and dysgeusia). Results Among the 1,744 tested participants, 144 tested positive for SARS-CoV-2. In the test-positive group, self-reported cough, fatigue, dysosmia, and dysgeusia were significant predictors of COVID-19, independent from a history of close contact. In particular, the presence of dysosmia was the strongest predictor of COVID-19 in both univariate and multivariate analyses. Among the 42 patients with self-reported dysosmia, 25 (59.5%) were SARS-CoV-2 test-positive. Self-reported dysosmia was reported by 25 (17.4%) of the 144 patients who tested positive for SARS-CoV-2, and 15 (60.0%) of the 25 COVID-19 patients with dysosmia had accompanying dysgeusia. Conclusion The presence of dysosmia was reported by 10-25% of patients with COVID-19, and is a significant predictor of COVID-19 infection, independent from a history of close contact.

  16. Impact of the COVID-19 pandemic on dental clinical training and future prospects. International-journal Peer-reviewed

    Takashi Nishioka, Gen Mayanagi, Yoko Iwamatsu-Kobayashi, Guang Hong

    Journal of dental education　2021/02/03

    DOI： 10.1002/jdd.12562 　

  17. Predictors of SARS-CoV-2 Positivity Based on RT-PCR Swab Tests at a Drive-Through Outpatient Clinic for COVID-19 Screening in Japan. Peer-reviewed

    Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

    The Tohoku journal of experimental medicine　253　(2)　101-108　2021/02

    DOI： 10.1620/tjem.253.101 　

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    In response to the COVID-19 pandemic caused by SARS-CoV-2 in 2020, we conducted drive-through nasopharyngeal swab testing for COVID-19 in Sendai city, Japan, since April 2020. All tested individuals were judged in advance by public health centers for the necessity of undergoing the test with possible contact history and/or symptoms suggestive of COVID-19. In this study, to identify the predictors of SARS-CoV-2 test positivity for more efficient and evidenced selection of suspected individuals, we enrolled 3,540 consecutive individuals, tested in the first 7 months of the testing program, with data regarding to the history of close contact with COVID-19 patients, including those involved in cluster outbreaks. This cohort included 284 foreign students (257 males and 27 females) from a vocational school involved in the largest cluster outbreak in the area. Close contact history was present in 952 (26.9%) of the participants. The reverse transcription-polymerase chain reaction (RT-PCR) test results showed that 164 participants (4.6%) were positive and 3,376 participants (95.4%) were negative for the SARS-CoV-2 nucleocapsid gene (N2). In the univariate and multivariate analyses, history of close contact with COVID-19 patients, higher age, cough symptoms, and non-native ethnicity were predictors for SARS-CoV-2 test positivity. However, the significance of age and foreign nationality disappeared or declined upon excluding the foreign students from the aforementioned largest cluster outbreak. In conclusion, a history of close contact with COVID-19 patients and the presence of cough symptoms are significant predictors of SARS-CoV-2 test positivity.

  18. Impacts of Natural Environmental Factors and Prevalence of Airway Symptoms on the Local Spread of COVID-19: A Time-Series Analysis in Regional COVID-19 Epidemics Peer-reviewed

    Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Noriko Sugawara, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

    The Tohoku Journal of Experimental Medicine　254　(2)　89-100　2021

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.254.89 　

    ISSN： 0040-8727

    eISSN： 1349-3329

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    Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the world's largest public health concern in 2021. This study evaluated the associations of the prevalence of airway symptoms among the tested individuals and data regarding the natural environmental factors with the weekly number of newly diagnosed COVID-19 patients in Sendai City (Nt). For the derivatives of the screening test results, data from individuals with a contact history who underwent nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) testing between July 2020 and April 2021 (6,156 participants, including 550 test-positive patients) were used. The value of Nt correlated with the weekly RT-PCR test-positive rate after close contact, prevalence of cough symptoms in test-positive individuals or in test-negative individuals, lower air temperature, lower air humidity, and higher wind speed. The weekly test-positive rate correlated with lower air humidity and higher wind speed. In cross-correlation analyses, natural environmental factors correlated with the regional epidemic status on a scale of months, whereas the airway symptoms among non-COVID-19 population affected on a scale of weeks. When applying an autoregression model to the serial data of Nt, large-scale movements of people were suggested to be another factor to influence the local epidemics on a scale of days. In conclusion, the prevalence of cough symptoms in the local population, lower air humidity or higher wind speed, and large-scale movements of people in the locality would jointly influence the local epidemic status of COVID-19.

  19. 災害歯科医療学実地研修会の参加者に対するアンケート調査

    小林 洋子, 西岡 貴志, 冨士 岳志, 齋藤 恵一, 洪 光, 江草 宏, 佐々木 啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　38回　149-149　2019/06

    Publisher: (一社)日本歯科医学教育学会

  20. Introduction of integrated dental training jaw models and rubric criteria. International-journal Peer-reviewed

    Taichi Tenkumo, Takeshi Fuji, Motohide Ikawa, Shigeru Shoji, Hiromi Sasazaki, Yoko Iwamatsu-Kobayashi, Yayoi Okuyama, Hiroyuki Matsui, Naru Shiraishi, Toshi Furuuchi, Keisuke Higuchi, Wataru Hashimoto, Yasuhisa Takeuchi, Hidetoshi Simauchi, Keiichi Sasaki

    European journal of dental education : official journal of the Association for Dental Education in Europe　23　(1)　e17-e31-e31　2019/02

    Publisher: Wiley

    DOI： 10.1111/eje.12395 　

    ISSN： 1396-5883

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    OBJECTIVE: The objective of the present study was to evaluate the effectiveness of introducing integrated jaw models, rubric criteria and homework tasks to a total clinical simulation training course to improve the clinical competence of preclinical dental students. METHODS: A total simulation training course, which involved six clinical dentistry departments, was held for 110 preclinical students in 2014 and 2015. We prepared integrated jaw models having several morbidities along with corresponding medical information and homework tasks. The students formulated diagnoses and devised treatment plans before performing dental treatment on the mannequin under the direction of instructors from the respective clinical departments. Their performance was assessed by both students and instructors using the rubric criteria. RESULTS: Based on quantitative evaluations, the introduction of integrated jaw models appeared to improve the students' ability to formulate diagnoses and devise dental treatment plans and to understand the respective clinical dentistry disciplines. The rubric criteria provided immediate feedback for the students. Based on a comparison of rubric scores, students tended to significantly underestimate their own performance compared with instructors. Moreover, the introduction of homework tasks improved student seriousness. CONCLUSION: Introducing integrated jaw models, rubric criteria and homework tasks to a total simulation training course may be a good approach for improving student performance in terms of dental diagnoses and treatment.

  21. Fibrillin-1 insufficiency alters periodontal wound healing failure in a mouse model of Marfan syndrome Peer-reviewed

    Keisuke Handa, Syouta Abe, V. Venkata Suresh, Yoshiyasu Fujieda, Masaki Ishikawa, Ai Orimoto, Yoko Kobayashi, Satoru Yamada, Satoko Yamaba, Shinya Murakami, Masahiro Saito

    Archives of Oral Biology　90　53-60　2018/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.archoralbio.2018.02.017 　

    ISSN： 0003-9969

    eISSN： 1879-1506

  22. Metal ions from S-PRG filler have the potential to prevent periodontal disease. International-journal Peer-reviewed

    Yoko Iwamatsu-Kobayashi, Syouta Abe, Yoshiyasu Fujieda, Ai Orimoto, Masafumi Kanehira, Keisuke Handa, Venkata Suresh Venkataiah, Wei Zou, Masaki Ishikawa, Masahiro Saito

    Clinical and experimental dental research　3　(4)　126-133　2017/08

    Publisher: Wiley

    DOI： 10.1002/cre2.70 　

    ISSN： 2057-4347

  23. 新規チタン製バリアメンブレンの各種培養細胞への効果 Peer-reviewed

    遠藤直樹, 小林洋子, 石幡浩志, 岩間張良, 菊池雅彦

    日本歯科保存学雑誌　58　(6)　503-509　2015

    Publisher: (NPO)日本歯科保存学会

    DOI： 10.11471/shikahozon.58.503 　

    ISSN： 0387-2343

    eISSN： 2188-0808

  24. The effect of titanium mesh surface on cultured human tooth germ-derived cells. Peer-reviewed

    IWAMATSU-KOBAYASHI Yoko, ENDO Naoki, ISHIHATA Hiroshi, IWAMA Nagayoshi, SHIMAUCHI Hidetoshi

    Jpn J Conserv Dent　55　226　2012

  25. Characterization of STRO-1 positive cells derived from human wisdom tooth germs Peer-reviewed

    Yoko Iwamatsu-Kobayashi, Daisuke Nishihara, Naoki Endo, Koji Kindaichi, Junko Kindaichi, Masashi Komatsu

    Interface Oral Health Science 2011　119-121　2012/01/01

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-54070-0_27 　

  26. The influence of mesenchymal stem cell growth medium for isolation of STRO-1 positive cells from human periodontal ligament Peer-reviewed

    Naoki Endo, Yoko Iwamatsu-Kobayashi, Daisuke Nishihara, Masaaki Iwamatsu, Masashi Komatsu, Masahiko Kikuchi

    Interface Oral Health Science 2011　122-124　2012/01/01

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-54070-0_28 　

  27. 永久歯に内部吸収のみられた歌舞伎メイキャップ症候群の1例． Peer-reviewed

    小林洋子, 金田一孝二, 金田一純子, 小松正志

    日歯保存誌　54　137　2011

  28. ビリルビン着色歯の漂白に関する研究 Peer-reviewed

    小林洋子, 笹崎弘己, 小松正志, 金田一孝二, 金田一純子

    日歯保存誌　53　135　2010

  29. Isolation and comparison of mesenchymal stem cells derived from human wisdom tooth germs and periodontal ligament in vitro Peer-reviewed

    Daisuke Nishihara, Yoko Iwamatsu-Kobayashi, Masatsugu Hirata, Koji Kindaichi, Junko Kindaichi, Masashi Komatsu

    INTERFACE ORAL HEALTH SCIENCE 2009　184-+　2010

    DOI： 10.1007/978-4-431-99644-6_42 　

  30. Mesenchymal Stem cells in Human Wisdom Tooth Germs Peer-reviewed

    Nishihara D. Iwamatsu-Kobayashi, Y. Hirata, M. Kindaichi, K. KindaichiJ, Komatsu M

    Interface Oral Health Science 2007　187-188　2007/08

  31. Multiple external root resorption Peer-reviewed

    Y. Iwamatsu-Kobayashi, S. Satoh-Kuriwada e

    Dental Abstracts　51　(4)　208-210　2006/07

  32. A case of multiple idiopathic external root resorption: a 6-year follow-up study. International-journal Peer-reviewed

    Yoko Iwamatsu-Kobayashi, Shizuko Satoh-Kuriwada, Toshinori Yamamoto, Masatsugu Hirata, Johji Toyoda, Hideaki Endo, Koji Kindaichi, Masashi Komatsu

    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics　100　(6)　772-9　2005/12

    DOI： 10.1016/j.tripleo.2004.11.047 　

    ISSN： 1079-2104

    eISSN： 1528-395X

  33. Effects of biomaterials on cell adhesion of human periodontal ligament fibroblasts and fibronectin adsorption Peer-reviewed

    Y. Iwamatsu-Kobayashi, D. Nishihara, M. Hirata, K. Kindaichi, M. Komatsu

    International Congress Series　1284　334-335　2005/09

    DOI： 10.1016/j.ics.2005.06.055 　

    ISSN： 0531-5131

  34. 生体吸収材料上における培養ヒト歯根膜由来線維芽細胞の動態 Peer-reviewed

    西原大輔, 岩松-小林洋子, 平田政嗣, 金田一孝二, 小松正志

    日歯保存誌　48　(4)　508-516　2005/04

  35. ラット歯根窩洞へ埋入したチタンインプラント周囲の組織学的観察 Peer-reviewed

    山本寿則, 金田一孝二, 只友陽太郎, 岩松洋子, 平田政嗣, 兼平正史, 小松正志

    日歯保存誌　46　(2)　255-262　2003/04

  36. Studies on root restoration : Embedding titanium and cultured periodontal ligament fibroblasts into the intradentinal cavities in dogs

    Yamamoto T, Hirata M, Iwamatsu Y

    Korean J. Conserv. Dent.　26　(6)　568-568　2001

  37. 培養ヒト歯根膜由来上皮細胞のアルカリフォスファターゼ活性発現 Peer-reviewed

    下西充, 長岡真一, 田上篤, 岩松洋子, 小松正志, 奥田禮一

    日歯保存誌　43　(2)　442-448　2000/04

    ISSN： 0387-2343

  38. 歯根修復に関する研究 第７報 イヌ歯根窩洞への培養歯根膜由来線維芽細胞の播種による歯根膜およびセメント質形成の可能性 Peer-reviewed

    岩松洋子, 平田政嗣, 山本寿則, 只友陽太郎, 下西充, 長岡真一, 兼平正史, 金田一孝二, 奥田禮一

    日歯保存誌　43　(2)　555-563　2000/04

    ISSN： 0387-2343

  39. 歯根修復に関する研究 第８報 イヌ歯根窩洞への培養歯根膜由来線維芽細胞の播種およびチタン片の埋入 Peer-reviewed

    平田政嗣, 岩松洋子, 山本寿則, 只友陽太郎, 下西充, 長岡真一, 樋口繁仁, 佐藤秀樹, 兼平正史, 金田一孝二, 奥田禮一

    日歯保存誌　43　(3)　738-746　2000/04

  40. アポトーシス制御による四肢発生への影響

    金田一孝二, 岩松洋子, 平田政嗣

    日本解剖学会誌　75　(1)　58-58　2000

  41. 多発性特発性歯根外部吸収を生じた1例 Peer-reviewed

    岩松洋子, 平田政嗣, 山本寿則

    日歯保存誌　42　(5)　555-563　1999

  42. Histochemical and immunohistochemical study of periodontal epithelial cells and cementoblasts forming acellular cementum in rat molar root Peer-reviewed

    Hirata Masatsugu, lwamatsu Yoko, Kindaichi Koji, Okuda Reiichi, Kagayama Manabu

    Japanese journal of oral biology　40　(6)　594-610　1998/12/20

    Publisher: Japanese Association for Oral Biology

    ISSN： 0385-0137

  43. On the developing periodontal ligament of rats, using a new specimen preparation method for SEM in comparison with histochemistry. Peer-reviewed

    Iwamatsu Y, Kindaichi K, Kagayama M, Okuda R

    Kaibogaku Zasshi　70　(4)　322-329　1995/08

    ISSN： 0022-7722

  44. Studies on Lining Material Containing Polyfunctional Carboxylate Monomer Part1. Its Pulp Response Peer-reviewed

    KANEHIRA Masafumi, KOSUGA Akira, CHIBA Shoichi, TAGAMI Atsushi, IWAMATSU Yoko, OKUDA Reiichi

    38　(2)　623-639　1995/04/28

    ISSN： 0387-2343

  45. THE PROCESS OF CALCIFICATION DURING DEVELOPMENT OF THE RAT TRACHEAL CARTILAGE CHARACTERIZED BY DISTRIBUTION OF ALKALINE-PHOSPHATASE ACTIVITY AND IMMUNOLOCALIZATION OF TYPE-1 AND TYPE-2 COLLAGENS AND GLYCOSAMINOGLYCANS OF PROTEOGLYCANS Peer-reviewed

    Y SASANO, MIZOGUCHI, I, M FURUSAWA, N AIBA, E OHTANI, Y IWAMATSU, M KAGAYAMA

    ANATOMY AND EMBRYOLOGY　188　(1)　31-39　1993/07

    ISSN： 0340-2061

Show all ︎Show first 5

Misc. 16

  1. 歯科治療で発生するエアロゾル挙動の可視化

    小林 洋子, 渡辺 隼, 梶田 倫功, 山内 健介, 金高 弘恭, 江草 宏, 五十嵐 薫, 矢代 航, 菊地 謙次, 西村 秀一, 森島 浩允, 佐藤 舜, 菅井 優生

    東北大学歯学雑誌　39/40/41　(2/1-2/1)　49-49　2022/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  2. Pannexin 3によるWnt/β-cateninおよびp21 signalingを介した骨前駆細胞の増殖機構の解析

    石河 真幸, 小林 洋子, 折本 愛, 半田 慶介, 齋藤 正寛

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集　145回　47-47　2016/10

    Publisher: (NPO)日本歯科保存学会

  3. 統合型病態模型を用いた臨床シミュレーション実習(第3報)

    天雲 太一, 竹内 裕尚, 井川 資英, 小林 洋子, 奥山 弥生, 古内 壽, 佐々木 啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　116-116　2016/07

    Publisher: 日本歯科医学教育学会

  4. S-PRGフィラー抽出液由来イオンによるマウス歯周炎モデル抑制機構の解析

    小林 洋子, 兼平 正史, 半田 慶介, 齋藤 正寛

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集　143回　199-199　2015/11

    Publisher: (NPO)日本歯科保存学会

  5. 大学病院保存・補綴系専門歯科診療外来における歯科衛生士による口腔衛生管理の患者動向について

    佐藤 由美子, 宍戸 敦子, 村上 裕理亜, 堀込 ゆかり, 梶原 貴子, 佐藤 明美, 畠山 佑衣, 土井 純子, 小林 洋子, 五十嵐 薫

    日本歯科衛生学会雑誌　10　(1)　136-136　2015/08

    Publisher: 日本歯科衛生学会

    ISSN： 1884-5193

  6. マルファン症候群モデルマウスにおける歯周炎の組織破壊機構に関する研究

    半田 慶介, 折本 愛, 小林 洋子, 齋藤 正寛

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集　142回　62-62　2015/06

    Publisher: (NPO)日本歯科保存学会

  7. Immunohistochemical Study of Mesenchymal Stem Cells in Human Wisdom Tooth Germ

    IWAMATSU KOBAYASHI Yoko, NISHIHARA Daisuke, HIRATA Masatsugu, KINDAICHI Koji, KINDAICHI Junko, KOMATSU Masashi

    49　174-174　2006/10/11

    ISSN： 0387-2343

  8. Studies on Root Restoration : Part.10 Microstructures and Mechanical properties of Porous Titanium Compacts and Culture of Periodontal Ligament Cells

    KANEHIRA Masafumi, HIRATA Masatugu, NISHIHARA Daisuke, YAMAMOTO Toshinori, IWAMATSU Yoko, KINDAICHI Koji, NOMURA Naoyuki, HANADA Syuji, SASAKI Keiichi, KOMATSU Masashi

    46　160-160　2003/05/06

    ISSN： 0387-2343

  9. Three-dimensional culture of human periodontal ligament fibroblasts

    IWAMATSU Yoko, HIRATA Masatsugu, NISHIHARA Daisuke, KINDAICHI Koji, KOMATSU Masashi

    45　119-119　2002/10/21

    ISSN： 0387-2343

  10. Studies on Root restoration : Part 9 Embedding Titanium and Microcarrier Cultured Periodontal Ligament Fibroblasts into the Intradentinal Cavities in Dogs

    HIRATA Masatsugu, MURAKAMI Yasuhiro, TADATOMO Yotaro, YAMAMOTO Toshinori, NAGAOKA Shinichi, IWAMATSU Yoko, KANEHIRA Masafumi, KINDAICHI Koji, KOMATSU Masashi, OKUDA Reiichi

    44　88-88　2001/04/27

    ISSN： 0387-2343

  11. The Large scale cultivation with microcarrier of the fibroblasts from human periodontal ligament

    MURAKAMI Yasuhiro, HIRATA Masatsugu, TAGAMI Atsusi, MIYA Yutaka, IWAMATSU Yoko, KINDAICHI Koji, OKUDA Reiichi

    42　78-78　1999/10/01

    ISSN： 0387-2343

  12. A study of regeneration in the rat molar periodontium

    YAMAMOTO Toshinori, IWAMATSU Yoko, HIRATA Masatsugu, TADATOMO Yotaro, KINDAICHI Koji, OKUDA Reiichi

    42　82-82　1999/10/01

    ISSN： 0387-2343

  13. Expression of Alkaline Phosphatase on Cultured Epithelial Cells from Human Periodontal Ligament

    SHIMONISHI Mitsuru, NAGAOKA Shinichi, TAGAMI Atsushi, IWAMATSU Yoko, KOMATSU Masashi, OKUDA Reiichi

    42　210-210　1999/10/01

    ISSN： 0387-2343

  14. Studies on Root restoration Part8 Embedding Titanium and cultured Periodontal Ligament Fibroblasts into the Intradentinal Cavities in Dogs

    HIRATA Masatsugu, IWAMATSU Yoko, YAMAMOTO Toshinori, TADAMOTO Yotaro, SHIMONISHI Mitsuru, NAGAOKA Shinichi, HIGUCHI Shigehito, SATO Hideki, KANEHIRA Masafumi, KINDAICHI Koji, OKUDA Reiichi

    42　164-164　1999/10/01

    ISSN： 0387-2343

  15. Studies on Root Restoration Part.7 Embedding cultured periodontal ligament fibroblasts into the intradentinal cavities in dogs

    IWAMATSU Yoko, HIRATA Masatsugu, YAMAMOTO Toshinori, TADAMOTO Yotaro, SHIMONISHI Mitsuru, NAGAOKA Shinichi, KANEHIRA Masafumi, KINDAICHI Koji, OKUDA Reiichi

    42　163-163　1999/10/01

    ISSN： 0387-2343

  16. A case of multiple idiopathic external root resorption

    IWAMATSU Yoko, HIRATA Masatsugu, YAMAMOTO Toshinori, OKUDA Reiichi, ENDO Hideaki, HORIUCHI Hiroshi

    41　36-36　1998/05/01

    ISSN： 0387-2343

Show all ︎Show first 5

Books and Other Publications 1

  1. 保存修復学専門用語集

    日本歯科保存学会

    医歯薬出版株式会社　2017/03

Presentations 41

  1. イオンと電界を利用した歯科飛沫エアロゾル吸引装置の開発

    渡辺 隼, 小林洋子, 倉内美智子, 金高弘恭, 江草 宏, 山田哲也, 栁田保子

    2024年度生体医歯工学共同研究拠点成果報告会　2025/01/25

  2. 東北大学病院歯科外来における過去10年間の転倒転落インシデントの推移と課題

    小林洋子, 倉内美智子, 渡辺隼, 草間太郎, 大友千賀, 坂本千尋, 西條文人, 田畑雅央, 杉浦剛, 江草宏

    第19回医療の質安全学会学術集会　2024/11/29

  3. マスクのノーズワイヤーの材質が飛沫エアロゾルの漏出に与える影響

    渡辺 隼,小林洋子,倉内美智子,江草 宏

    第33回日本口腔感染症学会学術大会　2024/09/21

  4. 歯科治療で発生する飛沫の 個人防護具への飛散

    倉内美智子, 渡辺隼, 小林洋子, 金髙弘恭, 江草宏

    第83回東北大学歯学会　2024/06/21

  5. 歯科医師によるワクチン予防接種の社会的意義と諸問題の考察 Invited

    小林洋子

    第10回宮城県地域医療学会　2022/03/12

  6. 東北大学病院歯科部門におけるCOVID-19に対する取り組み

    小林洋子, 渡辺隼, 板垣祐介, 江草宏, 五十嵐薫

    第４回国際歯科医療安全機構総会・学術大会　2021/11/23

  7. Initial Response to the COVID-19 Crisis in Dental Departments of Tohoku University Hospital Invited

    Yoko Kobayashi

    Japan-Mongolia Special Forum on COVID-19　2021/01/12

  8. 災害歯科医療学実地研修会の参加者に対するアンケート調査

    小林洋子, 西岡貴志, 冨士岳志, 齋藤恵一, 洪光, 江草宏, 佐々木啓一

    第38回日本歯科医学教育学会学術大会　2019/07/19

  9. 留学生臨床トレーニングにおけるSIMROID®の有用性

    洪光, 小林洋子, 西岡貴志, 齋藤恵一, 江草宏, 佐々木啓一

    .ヒューマノイド歯科教育研究会第2回研究発表会　2018/11/15

  10. Pannexin 3 によるWnt/b-cateninおよびp21 signalingを介した骨前駆細胞の増殖機構の解析

    石河真幸, 小林洋子, 折本愛, 半田慶介, 齋藤正寛

    第145回日本歯科保存学会2016年度秋季学術大会　2016/10/27

  11. IMPROVEMENT OF CLINICAL SIMULATION TRAINING UTILIZING INTEGRATED DENTAL TRAINING MODEL-part3-. International-presentation

    Tenkumo T, Takeuchi Y, Ikawa M, Iwamatsu-Kobayashi Y, Okuyama Y, Matsui H, Furuuchi T, Higuchi K, Sasaki K

    The 42nd Annual meeting of Association for Dental Education in Europe　2016/08/24

  12. 統合型病態模型を用いた臨床シミュレーション実習－第３報－

    天雲太一, 竹内裕尚, 井川資英, 奥山弥生, 古内壽, 小林洋子, 佐々木啓一

    第35回日本歯科医学教育学会学術大会　2016/07/01

  13. The effect of S-PRG filler eluate on periodontitis models. International-presentation

    IWAMATSU-KOBAYASHI Yoko, ORIMOTO Ai, VENKATAIAH Venkata Suresh, KANEHIRA Masafumi, HANDA Keisuke, SAITO Masahiro

    The 6th International symposium for interface oral health science　2016/01/18

  14. S-PRGフィラー抽出液由来イオンによるマウス歯周炎モデル抑制機構の解析.

    小林洋子, 兼平正史, 半田慶介, 齋藤正寛

    第143回日本歯科保存学会2015年度秋季学術大会　2015/11/12

  15. 大学病院保存・補綴系専門歯科診療外来における有病受診患者の調査とその対応

    宍戸敦子, 佐藤由美子, 小林洋子

    日本歯科衛生学会第10回学術大会　2015/09/20

  16. 大学病院保存・補綴系専門歯科診療外来における歯科衛生士による口腔衛生管理の患者動向について

    佐藤由美子, 宍戸敦子, 小林洋子

    日本歯科衛生学会第10回学術大会　2015/09/20

  17. マルファン症候群モデルマウスにおける歯周炎の組織破壊機構に関する研究

    半田慶介, 折本愛, 小林洋子, 齋藤正寛

    第142回日本歯科保存学会2015年度春季学術大会　2015/06/25

  18. Development of S-PRG Filler as a dental material that has an ability of preventing periodontal disease. International-presentation

    IWAMATSU-KOBAYASHI Yoko, ORIMOTO Ai, HANDA Keisuke, SAITO Masahiro

    94th IADR　2015/03/12

  19. Effect of S-PRG Filler Eluate on the Tissue Destruction of the Ligature-induced Periodontitis Model International-presentation

    IWAMATSU-KOBAYASHI Yoko, ORIMOTO Ai, HANDA Keisuke, SAITO Masahiro

    62nd JADR　2014/12/05

  20. S-PRGフィラー抽出液によるマウス歯周炎モデル予防効果の解析

    小林洋子, 安倍翔大, 折本愛, 齋藤正寛

    第141回日本歯科保存学会2014年度秋季学術大会　2014/10/30

  21. F-spondin involved in periodontal ligament differentiation through regulation of TGF-b activity

    IWAMATSU-KOBAYASHI Yoko, ABE Shota, Fujieda Yoshiyasu, SAITO Masahiro

    2014/01/20

  22. The effect of the differentiation of cultured human cells on titanium mesh

    ENDO Naoki, IWAMATSU-KOBAYASHI Yoko, IWAMA Nagayoshi, ISHIHATA Hiroshi, SHIMAUCHI Hidetoshi, KIKUCHI Masahiko

    The 5th International symposium for interface oral health science　2014/01/20

  23. 培養ヒト智歯歯胚由来細胞に対するチタンメッシュの効果

    小林洋子, 遠藤直樹, 石幡浩志, 岩間張良, 島内英俊

    第136回日本歯科保存学会2012年度秋季学術大会　2012/11/22

  24. 20μmチタンメッシュを用いた歯周組織再生

    石幡浩志, 岩間張良, 小林洋子, 島内英俊

    第55回日本歯周病学会春季学術大会　2012/05/17

  25. 永久歯に内部吸収のみられた歌舞伎メイキャップ症候群の1例

    小林洋子, 金田一孝二, 金田一純子, 小松正志

    第135回日本歯科保存学会2011年度秋季学術大会　2011/10/20

  26. ビリルビン着色歯の漂白に関する研究

    小林洋子, 笹崎弘己, 小松正志, 金田一孝二, 金田一純子

    第133回日本歯科保存学会　2010/10/28

  27. Isolation and comparison of mesenchymal stem cells derived from human International-presentation

    Nishihara D, Iwamatsu-Kobayashi Y, Hirata M, Kindaichi K, KindaichiJ, Komatsu M

    The 3rd International Symposium for Interface Oral Health Science in　2009/01/15

  28. Mesenchymal Stem Cells in Human Wisdom Tooth Germs

    D. Nishihara, Y. Iwamatsu-Kobayashi, M. Hirata, J. Kindaichi, K. Kindaichi, M. Komatsu

    2nd International Symposium for Interface Oral Health Science　2007/02/18

  29. Mesenchymal Stem cells in Human Wisdom Tooth Germs International-presentation

    Nishihara D, Iwamatsu-Kobayashi Y, Hirata M, Kindaichi K, KindaichiJ, Komatsu M

    The 2nd International Symposium for Interface Oral Health Science in　2007/02/18

  30. ヒト智歯歯胚における幹細胞の免疫組織化学的検討

    岩松ー小林洋子, 西原大輔, 平田政嗣, 金田一孝二, 金田一純子, 小松正志

    第125回日本歯科保存学会　2006/11/09

  31. ラット歯根膜再生過程におけるコラーゲンスポンジの架橋の影響

    西舘都子, 平田政嗣, 岩松-小林洋子, 西原大輔, 金田一孝二, 小松正志

    第123回日本歯科保存学会　2005/10

  32. 架橋の異なるコラーゲンスポンジにおける培養歯根膜由来線維芽細胞の動態

    西原大輔, 岩松-小林洋子, 平田政嗣, 西舘都子, 金田一孝二, 小松正志

    第123回日本歯科保存学会　2005/10

  33. 粒子焼結法による多孔質チタンの機械的特性と生体親和性に関する検討

    鈴木祐子, 野村直之, 兼平正史, 小林-岩松洋子, 小松正志, 花田修治, 佐々木啓一

    第111回日本歯科補綴学会　2004/05

  34. Effects of bio-absorbable scaffold materials to human periodontal ligament fibroblasts

    Nishihara D, Iwamatsu Y, Hirata M, Kindaichi K, Komatsu M

    2004 IADR meeting　2004/03/13

  35. 純チタンへの培養歯根膜由来線維芽細胞の接着

    岩松洋子, 西原大輔, 平田政嗣, 山本寿則, 金田一孝二, 小松正志

    第25回日本バイオマテリアル学会　2003/12

  36. 多孔質マイクロキャリアを用いた歯根膜由来線維芽細胞の培養

    平田政嗣, 岩松洋子, 西原大輔, 山本寿則, 金田一孝二, 小松正志

    第２５回日本バイオマテリアル学会　2003/12

  37. 歯根修復に関する研究 第１０報 多孔質チタン体の試作およびヒト歯根膜由来細胞の培養

    兼平正史、平田政嗣、西原大輔、山本寿則、岩松洋子、金田一孝二、野村義之、花田修 治、佐々木啓一、小松正志

    第118回日本歯科保存学会　2003/06

  38. 歯根膜由来線維芽細胞の立体培養

    岩松洋子, 平田政嗣, 西原大輔, 金田一孝二, 小松正志

    第117回日本歯科保存学会　2002/10

  39. EGFおよびDexamethasone刺激における歯根膜由来細胞のシグナル伝達に関する研究

    岩松洋子, 金田一孝二, 小松正志

    第116回日本歯科保存学会　2002/06

  40. 歯根修復に関する研究 第9報 マイクロキャリア培養法を応用した培養歯根膜細胞およびチタン片のイヌ歯根窩洞への埋入

    平田政嗣, 村上安弘, 只友陽太郎, 岩松洋子

    第114回日本歯科保存学会　2001/06

  41. ラット歯根窩洞へのチタンインプラント体埋入に関する研究

    只友陽太郎, 金田一孝二, 岩松洋子

    第114回日本歯科保存学会　2001/06

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Research Projects 14

  1. The development of a novel preventive method of periodontal disease using S-PRG Filler eluate Competitive

    Iwamatsu-Kobayashi Yoko, SUZUKI OSAMU

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04 - 2017/03

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    S-PRG filler, a component of composite resin, is capable of releasing 6 metal ions that possess antibacterial activity against caries and periodontal pathogens. Although S-PRG has been suggested to be involved in oral disease prevention, no reports have been published regarding its preventive effect on periodontal disease in vivo. The present study investigated whether the eluate from S-PRG (S-PRG eluate) has a preventive effect on a mouse model of ligature-induced periodontal disease. C57BL/6 mice were divided into three groups; no ligature, ligature and ligature with S-PRG eluate group. S-PRG eluate clearly inhibited alveolar bone loss of ligature-induced periodontal disease and reduced the infiltration of inflammatory cells. TOF-SIMS analysis revealed that more boron ions were present in the S-PRG group. Our results suggest that the S-PRG eluate has a preventive effect against tissue destruction in periodontal disease through its anti-inflammatory effects in vivo.

  2. Development of novel anti-inflammatory therapy for apical periodontal disease using mesenchymal cell transplantation

    Masahiro Saito, YOSHIDA KYOKO, KOBAYASHI YOKO, SAITO TADAO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2014/04/01 - 2016/03/31

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    In the present study, we attempt to develop anti-inflammatory therapy for apical periodontitis. To achieve this purposes, we investigate matricellular proteins which is a extracellular matrix involving acceleration of immune response. We found that reduced expression of fibrillin-1 that regulate tissue elasticity is excavated inflammatory response of periodontal tissue. From these findings, reduction of fibrillin-1 play an important role in the progression of apical periodontal disease. We also established alveolar bone derived immature osteoblast obtained from human alveolar bone. These cells has a high osteogenic ability and bone forming ability in vivo. We are investigating anti-inflammatory effect of these cells.

  3. Safe and comfortable of monitoring of human blood sugar rate by using implantable glucose measuring device in the periodontal gingiva

    Ishihata Hiroshi, SHIMAUCHI HIDETOSHI, KOBAYASHI YOKO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    In this study, we have represented a novel design to achieve a CGM (continuous glucose monitoring) system incorporated for the bone regenerative therapy what the electronic device of blood sugar sensor can be assembled to the thin titanium mesh for bone augmentation surgery. This method has a feasibility of the implantable CGM that the ready-made CGM telemetry device can be placed in gingival tissue and operated to measure the blood sugar rate for a long period under the gums. A flexible electronic substrate with exclusive durability and biocompatibility has become to achieve this technology. We have completed producing a precision micro-porous plate (titanium membrane) with pure titanium. This is not only provided as a barrier membrane for GBR and GTR surgery but used for the substrate for CGM telemetry device. The titanium membrane has also blood flow permeability to prevent inhibiting the blood circulation in the living tissue to stably indwelling embedded electronic circuitry.

  4. The development of a novel biohybrid material for tooth root restoration

    IWAMATSU-KOBAYASHI Yoko, NISHIHARA Daisuke, ICHIKAWA Hiroyuki, KOMATSU Masashi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2010/04 - 2014/03

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    We examined the influence of mesenchymal stem cells growth medium (MSCGM) for STRO-1 positive cells derived from PDL compared with DMEM. PDL cells cultured in MSCGM showed colony formation and the isolation rate was higher than that in DMEM. STRO-1 positive cells derived from human wisdom tooth germs collected using MSCGM showed Alcian blue positive matrix when cultured in chondrogenic induction medium. They also performed nodule formation stained with Alizarin red cultured in osteogenic induction medium. We have designed a titanium sheet with two-dimensional porous array of 20um pored mesh which was almost same as the diameter of Sharpeys fiber and numerous holes were densely pierced. We investigated the effect of the differentiation of cells on the titanium mesh. Frios Bone Shield was used as control. The cells on the titanium mesh expressed higher osteopontin and osteocalcin expression around the pore compared with the Frios.

  5. Development of novel root restorative materials based on tissue engineering

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2005 - 2007

  6. Development and application of hybrid biomaterials with periodontal tissue regeneration potential

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Exploratory Research

    Category: Grant-in-Aid for Exploratory Research

    Institution: Tohoku University

    2004 - 2006

  7. Establishment of artificial root restoration with periodontal ligament tissue -Especially on construction of artificial Sharpie fiber-

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2002 - 2004

  8. Artificial root restoration and periodontal ligament tissue reconstruction mechanism

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A)

    Category: Grant-in-Aid for Encouragement of Young Scientists (A)

    Institution: Tohoku University

    1999 - 2000

  9. Construction of periodontal ligament tissue around artificial dental roots

    OKUDA Reiichi, MOTEGI Katsutoshi, WATANABE Makoto, KAGAYAMA Manabu, IWAMATSU Yoko, SHIMIZU Yoshinobu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: TOHOKU UNIVERSITY

    1998 - 1999

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    1. The three-dimensional cell culture became possible of periodontal ligament cells with microcarrier. The adequate condition of the culture was clarified. 2. Periodontal epithelial cells expressed alkaline phosphatase activity in vitro, not in vivo. It suggests that periodontal epithelial cells transformed in the culture environment. 3. PDL cells controled osteoclastogenesis in vitro by express both ODF and OCIF mRNA. 4. Decreasing of collagen αI(1) mRNA level and DNA methylation in the collagen αI(1) gene promotor region related to age-dependent degenerative alteration in periodontal tissue. 5. Human periodontal ligament cells expressed CD14 mRNA and membrane CD14 at low level as compared with human gingival fibroblasts, and exhibited an only low response to LPS. 6. It was suggested that periodontal epithelium (PE) had a role of the differentiation of cementoblasts during the acellular cementum formation. On the other hand, the PE in cellular cementum region was took part in the intermediate cementum and indicted the positive reaction of TUNEL. 7. From the observation of healing process of the fenestration defect through the bone extended into the root surface, it was suggested that periodontal ligament could regenerate only from the original healthy periodontal ligament and the regeneration process of cementum was similar to the remodeling of bone. 8. The cementum- and periodontal ligament-like tissue was observed on the titanium implants embedded in the cementum and periodontal ligament. On the other hand, bone was observed on the implants embedded in the alveolar bone. 9. It was suggested that the cell-seeding of PDL cells into the intradentinal cavities enhanced the isolated cementum formation. The BrdU marked PDL cells were detected only in the seeded cavities by immunohistochemical method. 10. The periodontal ligament-like tissue with newly formed cementum-like tissue was observed on the titanium embedded into the intradentinal cavities with cultured periodontal ligament cells in dogs. 11. It is suggested that periodontal mechanosensitive neurons which were sensitive to the incisor and molar teeth project topographically to the different areas of the primary and secondary somatosensory cortex.

  10. Elucidation of the mechanism of periodontal ligament tissue reconstruction in root restoration

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A)

    Category: Grant-in-Aid for Encouragement of Young Scientists (A)

    Institution: Tohoku University

    1997 - 1998

  11. The recontsruction of periodontal ligament on artificial dental roots

    OKUDA Reiichi, IWAMATSU Yoko, SHIMIZU Yoshinobu, MOTEGI Katsutoshi, WATANABE Makoto, KAGAYAMA Manabu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku Univ.

    1995 - 1997

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    1.Cultured cells 1) The fibroblasts derived from periodontal ligament suppressed the apparence of osteoclast-like cells when co-cultured with peripheral blood lymphocytes/monocytes unlike fibroblasts from gingiva and osteoblasts. 2) Growth and differentiation (ALPase activity) of the cloned fibroblasts in explant cultures of human periodontal ligament were studied. Their individual clones had various characterizations. 3) When the explants of human periodontal ligament were cultured by serum-free MCDB153 medium after attachment to the substrate, the epithelial cells that were immuno-positive for the anti-cytokeratin antibody were observed like as pave stone in morphology. Their growth and differentiation were different from those of human gingiva. 2.Extracellular matrices during the formation of periodontal ligament 1) There was a correlation between ALPase activity of fibroflasts and the morphology of cells, fibers and Hertwig's epithelial root sheath during the formation of periodontal ligament. 2) Cementoblasts that were forming cementum showed positive reaction of anti-osteocalcin antibody as well as osteoblasts and odontoblasts. 3) The reaction of anti-glycosaminoglycans antibody was shown in the low calcified cellular cementum and it was changed by aging. 3.Functions of various cells in periodontal ligament 1) Fibroblasts in periodontal ligament showed ACPase activity and the positive reaction of anti-F4/80 and MOMA-2 antibody and they were changed by the occlusal function. 2) Morphological charateristics and distribution of epithelial rests of Malassez were elucidated by immunohistochemical methods in vivo. The epithelial cells were demonstrated the same distribution of cementoblasts and located near the area synthesized much quantities of cementum by vital staining method, and they would participate in cementogenesis and synthesizing cementum. Furthermore, in these epithelial cells, the incorporation of BrdU was not observed, but the reaction of bcl-2 protein considered as one of the suppressors of appoptosis was observed by immunohistochemical methods. 3) Cementocytes were suggested to participate in secondaly mineralization of cellular cementum and homeostasis of the width of periodontal ligament.

  12. 上皮性歯胚,唇溝堤,上・下顎突起移行部にみられるアポトーシスの比較検討

    金田一 孝二, 岩松 洋子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 一般研究(C)

    Institution: 東北大学

    1995 - 1995

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    細胞に自在する高度に制御された生理過程である自壊機構であるアポトーシスが発生途上でも見られる.しかし、その意味するところは今だ不明であるので、上・下顎隆起移行部、上皮性歯胚、唇溝堤でのアポトーシスの出現の波、局在、さらに、死んだ細胞の運命、細胞死の出現した部位のその後の変化を、特に、染色体DNAの断片化をもってアポトーシスとする指標も加えて、形態的に類似しているアポトーシスのこれらの組織での関わりを組織化学的に比較検討を試みた.胎生9日〜19日のマウス胎仔と生後0日の新産仔を用い、4%パラフォルムアルデハイド液にて潅流固定し、パラフィン、凍結包理した.GavrieliらのTUNEL法(1992)により、パラフィン切片をラベルし、DAB反応させた.また、凍結切片から電顕試料を作成した.結果は胎生9日から前頭隆起と下顎隆起の移行部から上顎隆起が形成され、隆起の移行部の多層の上皮にアポトーシスが形成期間を通じて観察された.マウス歯胚は胎生12日から形成が始まり、その歯堤、歯胚上皮、特に、胎生15日の杯状期エナメル結節内にアポトーシスが著明に観察された.また、胎生14日の切歯歯胚の唇溝堤にアポトーシスがみられた.上・下顎移行部でのアポトーシスはkerrらのいうように、細胞がDNAの断片化をおこし、隣接細胞から遊離し、細分化され、隣接細胞などに取り込まれていたが、上皮性歯胚、唇溝堤でのアポトーシスでは、核の濃縮から始まり、遊離し、細分化されず小体状で隣接上皮細胞に取り込まれ、しかも、DNA断片化が観察されたのは、アポトティック小体が隣接細胞に取り込まれてからと思われる.唇溝堤、歯胚ではアポトーシスの出現した後の領域の上皮が分化することから、細胞分化に関係すると思われるが、移行部での違いなどは今後、apoptosis関連タンパク質に対する抗体などを用いて、アポトーシスの開始の兆候などをも調べ、アポトーシスの意味するところを追求する.

  13. Elucidation of the periodontal ligament tissue reconstruction mechanism

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A)

    Category: Grant-in-Aid for Encouragement of Young Scientists (A)

    Institution: Tohoku University

    1995 - 1995

  14. Elucidation of viricidal and sterilizing mechanism of oxidizing potential water

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C)

    Category: Grant-in-Aid for General Scientific Research (C)

    Institution: Tohoku University

    1995 - 1995

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Teaching Experience 3

  1. 歯科臨床入門　東北大学歯学部

  2. 感染予防歯科学　東北大学大学院歯学研究科

  3. 保存修復学　東北大学歯学部