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Hitoshi Oshitani

Section

Graduate School of Medicine

Job title

Professor

Degree

Master of Public Health
博士（医学）（東北大学）

researchmap

https://researchmap.jp/oshitanih

J-GLOBAL ID

200901043622948221

Research History 8

2005 - Present

東北大学医学系研究科　教授教授
2004 - 2005

WHO西太平洋事務局　感染症地域アドバイザー感染症地域アドバイザー
1998 - 1999

新潟大学医学部　助教、講師助教、講師
1995 - 1997

東北大学加齢医学研究所付属病院　医員医員
1991/01 - 1995/04

国立仙台病院　研究員研究員
1991 - 1994

国際協力事業団感染症対策プロジェクト長期専門家　専門家専門家
1989/04 - 1990/12

国立仙台病院　レジデントレジデント
1987/05 - 1989/03

国立仙台病院　研修医研修医

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Education 2

テキサス大学　School of Public Health　Master of Public Health

1995 - 1997
Tohoku University　Faculty of Medicine

1980 - 1987

Committee Memberships 18

内閣官房　委員新型インフルエンザ等対策有識者会議

2018/08 - Present
宮城県　新型インフルエンザ対策アドバイザーチーム

2018 - Present
内閣官房　新型インフルエンザ等対策有識者会議

2018 - Present
東京都　新型インフルエンザ等対策有識者会議委員長

2018 - Present
宮城県　感染症対策員会

2017/07 - Present
日本医療研究開発機構　課題評価委員

2017/06 - Present
厚生科学審議会　専門委員

2017/04 - Present
日本熱帯医学会　理事

2017/04 - Present
日本医療研究開発機構　課題評価委員

2017 - Present
厚生労働省　厚生科学審議会

2017 - Present
宮城県　感染症対策員会

2017 - Present
国際緊急援助隊　感染症対策チーム支援委員会

2015 - Present
日本熱帯医学会　評議員

2010/09 - Present
日本ウイルス学会　評議員

2010/04 - Present
日本熱帯医学会　理事

- Present
国際緊急援助隊　感染症対策チーム支援委員会

- Present
日本ウイルス学会　編集委員

2008 - 2011
日本熱帯医学会　編集委員

2006 - 2011

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Professional Memberships 5

Japanese Society for Infectious Diseases
THE JAPANESE SOCIETY FOR VIROLOGY
Japanese Society for Bacteriology (Tohoku Branch)
JAPANESE SOCIETY OF TROPICAL MEDICINE
JAPANESE SOCIETY OF PUBLIC HEALTH

Research Interests 4

Pathogenesis of viral infections
Molecular epidemiology of viruses
Control of infectious diseases
Epidemiology of viral infections

Research Areas 2

Life sciences / Healthcare management, medical sociology / Infectious Disease Epidemiology
Life sciences / Virology /

Papers 257

Norovirus-associated diarrhea and asymptomatic infection in children aged under 4 years: a community-cohort study in the Philippines. International-journal

Chuyao Yu, Maria Carmen A Corpuz, Joseph M Bonifacio, Makiko Kishi, Takeaki Imamura, Yusuke Sayama, Mariko Saito-Obata, Clyde Dapat, Michiko Okamoto, Hitoshi Oshitani, Mayuko Saito

IJID regions　14　100549-100549　2025/03

DOI： 10.1016/j.ijregi.2024.100549 　

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OBJECTIVES: This study aimed to estimate the incidence of norovirus (NoV)-associated diarrhea and asymptomatic infections in children under 4 years of age and identify the genotypes of multiple NoV infections. METHODS: A community-based cohort study was conducted in Tarlac, Philippines. Children aged 0-2 years were followed up for 2 years. The prevalence and incidence rates of NoV-associated diarrhea and asymptomatic infections were calculated. Risk factors were assessed using the Cox proportional hazards model. The genotypes and immunotypes of repeated infections were tabulated. RESULTS: A total of 338 children aged 6208 child-months were analyzed. NoV was detected in 17.4% (84 of 527, 95% confidence interval [CI]: 12.7-19.7%) of diarrheal episodes and 10.8% (219 of 2031, 95% CI: 9.4-12.3%) of asymptomatic stool samples. The highest incidence of NoV-associated diarrhea occurred in children aged 6-11 months (2.31 per 100 child-months, 95% CI: 1.30-3.32) and 18-23 months (2.34 per 100 child-months, 95% CI: 1.57-3.12), whereas the highest incidence of asymptomatic NoV infection was observed in children aged 12-23 months (4.49 per 100 child-months, 95% CI: 3.41-5.56). Repeated NoV infections were detected between different genotypes, except in two children who had repeated NoV GI.3 and two children with GI.9 infections. CONCLUSIONS: Children had the highest risk of NoV-associated diarrhea during their first year of life, whereas asymptomatic NoV infections persisted after the second year. Repeated NoV infections suggest genotype-specific immunity after NoV infection.
Serological analyses against endemic human coronaviruses and SARS-CoV-2 in children and adults using samples collected before the COVID-19 pandemic. International-journal

Yusuke Sayama, Chuan Lo, Hiroki Tomizawa, Mayuko Saito, Michiko Okamoto, Suguru Ohmiya, Hidekazu Nishimura, Hitoshi Oshitani

IJID regions　13　100485-100485　2024/12

DOI： 10.1016/j.ijregi.2024.100485 　

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OBJECTIVES: Four endemic human coronaviruses (HCoVs), HCoV-229E, HCoV-NL63, HCoV-HKU1, and HCoV-OC43, infect humans during childhood and cause the common cold. COVID-19 caused by SARS-CoV-2 leads to mild symptoms in children, possibly owing to the protection conferred by immunity developed during a previous HCoV infection. This study analyzed the seroreactivity of four endemic HCoVs and SARS-CoV-2 in children and adults. METHODS: A total of 747 serum samples (from individuals aged 6 months to 69 years) were collected from 2015 to 2019 before the COVID-19 pandemic in Japan. The samples were tested for immunoglobulin G antibodies against the four endemic HCoVs and SARS-CoV-2 wild-type spike ectodomain proteins using enzyme-linked immunosorbent assay. RESULTS: The seroprevalence of endemic HCoVs (except HCoV-229E) showed 90% positivity by 3-4 years old, whereas HCoV-229E seroprevalence was observed at 8 years old. Approximately 35% of the samples showed reactivity to SARS-CoV-2 and did not change with age. However, the children's group presented higher antibody levels than the adult group. The sample reactivity against SARS-CoV-2 did not confirm neutralization capability. CONCLUSIONS: The reactive samples against SARS-CoV-2 showed varying antibody levels among different age groups. These findings may contribute to a deeper understanding of the clinical symptoms of COVID-19 and coronavirus diseases.
Characterization of human respiratory syncytial virus in children with severe acute respiratory infection before and during the COVID-19 pandemic. International-journal

Paul Simusika, Michiko Okamoto, Clyde Dapat, Walter Muleya, Moffat Malisheni, Sikandar Azam, Takeaki Imamura, Mayuko Saito, Innocent Mwape, Evans Mpabalwani, Mwaka Monze, Hitoshi Oshitani

IJID regions　11　100354-100354　2024/06

DOI： 10.1016/j.ijregi.2024.03.009 　

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OBJECTIVES: Annual outbreaks of human respiratory syncytial virus (HRSV) are caused by newly introduced and locally persistent strains. During the COVID-19 pandemic, global and local circulation of HRSV significantly decreased. This study was conducted to characterize HRSV in 2018-2022 and to analyze the impact of COVID-19 on the evolution of HRSV. DESIGN/METHODS: Combined oropharyngeal and nasopharyngeal swabs were collected from children hospitalized with severe acute respiratory infection at two hospitals in Zambia. The second hypervariable region of the attachment gene G was targeted for phylogenetic analysis. RESULTS: Of 3113 specimens, 504 (16.2%) were positive for HRSV, of which 131 (26.0%) and 66 (13.1%) were identified as HRSVA and HRSVB, respectively. In early 2021, an increase in HRSV was detected, caused by multiple distinct clades of HRSVA and HRSVB. Some were newly introduced, whereas others resulted from local persistence. CONCLUSIONS: This study provides insights into the evolution of HRSV, driven by global and local circulation. The COVID-19 pandemic had a temporal impact on the evolution pattern of HRSV. Understanding the evolution of HRSV is vital for developing strategies for its control.
Identification of Various Recombinants in a Patient Coinfected With the Different SARS-CoV-2 Variants. International-journal

Yusuke Sayama, Akie Sakagami, Michiko Okamoto, Masahiro Sakamoto, Hikari Koizumi, Yoko Kimura, Clyde Dapat, Mayuko Saito, Yuko Suzuki, Mie Sasaki, Naoko Sugawara, Hitoshi Oshitani

Influenza and other respiratory viruses　18　(6)　e13340　2024/06

DOI： 10.1111/irv.13340 　

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BACKGROUND: Viral recombination that occurs by exchanging genetic materials between two viral genomes coinfecting the same host cells is associated with the emergence of new viruses with different virulence. Herein, we detected a patient coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants and identified various recombinants in the SARS-CoV-2 full-length spike gene using long-read and Sanger sequencing. METHODS: Samples from five patients in Japan with household transmission of coronavirus disease 2019 (COVID-19) were analyzed using molecular assays for detection and identification of SARS-CoV-2. Whole-genome sequencing was conducted using multiplex PCR with short-read sequencing. RESULTS: Among the five SARS-CoV-2-positive patients, the mutation-specific assay identified the Delta variant in three, the Omicron variant in one, and an undetermined in one. The undermined patient was identified as Delta using whole-genome sequencing, but samples showed a mixed population of Delta and Omicron variants. This patient was analyzed for viral quasispecies by long-read and Sanger sequencing using a full-length spike gene amplicon. In addition to the Delta and Omicron sequences, the viral quasispecies analysis identified nine different genetic recombinant sequences with various breakpoints between Delta and Omicron sequences. The nine detected recombinant sequences in the spike gene showed over 99% identity with viruses that were detected during the Delta and Omicron cocirculation period from the United States and Europe. CONCLUSIONS: This study demonstrates that patients coinfected with different SARS-CoV-2 variants can generate various viral recombinants and that various recombinant viruses may be produced during the cocirculation of different variants.
ウイルス培養に基づく新型コロナウイルスのPCR及び抗原定量検査のカットオフ値の検討

岡本道子, 坂本雅弘, 岸真紀子, 岡本聡, 大場千優, 齋藤繭子, 押谷仁

日本臨床微生物学会雑誌　34　(Suppl.1)　312-312　2023/12
Publisher: (一社)日本臨床微生物学会
ISSN： 2434-866X
Patient Admission and Mechanical Ventilator Allocation Decision-Making Processes by Frontline Medical Professionals in a Japanese ICU During the COVID-19 Pandemic: A Qualitative Study

Sakura Ishizaki, Kazuaki Jindai, Hiroki Saito, Hitoshi Oshitani, Tess Kulstad Gonzalez

Qualitative Health Research　2023/10/17
Publisher: SAGE Publications
DOI： 10.1177/10497323231201026 　

ISSN： 1049-7323

eISSN： 1552-7557

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During the COVID-19 pandemic, the need to triage COVID-19 patients in ICUs emerged globally. Triage guidelines were established in many countries; however, the actual triage decision-making processes and decisions themselves made by frontline medical providers may not have exactly reflected those guidelines. Despite the need to understand decisions and processes in practice regarding patient ICU admission and mechanical ventilator usage to identify areas of improvement for medical care provision, such research is limited. This qualitative study was conducted to identify the decision-making processes regarding COVID-19 patient ICU admissions and mechanical ventilator allocation by frontline medical providers and issues associated with those processes in an ICU during the COVID-19 pandemic. Semi-structured, in-depth interviews were conducted with ICU physicians and nurses working at an urban tertiary referral hospital in Japan between February and April 2022. Patient characteristics that influenced triage decisions made by physicians and the interaction between physicians, nurses, and senior management staff upon making such decisions are discussed in this article. An implicated issue was the lack of legal support for Japanese physicians to practice withdrawal of life-sustaining treatments even during emergencies. Another issue was the impact of non-clinical forces—likely specific to health emergencies—on physicians’ decisions regarding mechanical ventilator allocation, where such forces imposed a significant mental burden on the medical providers. We consider public policy and legal implications for future pandemics.
Time-varying overdispersion of SARS-CoV-2 transmission during the periods when different variants of concern were circulating in Japan. International-journal

Yura K Ko, Yuki Furuse, Kanako Otani, Masato Yamauchi, Kota Ninomiya, Mayuko Saito, Takeaki Imamura, Alex R Cook, Tadayuki Ahiko, Shunji Fujii, Yoshiharu Mori, Emiko Suzuki, Keiko Yamada, Yoshikazu Ashino, Hidetoshi Yamashita, Yuichi Kato, Katsumi Mizuta, Motoi Suzuki, Hitoshi Oshitani

Scientific reports　13　(1)　13230-13230　2023/08/14

DOI： 10.1038/s41598-023-38007-x 　

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Japan has implemented a cluster-based approach for coronavirus disease 2019 (COVID-19) from the pandemic's beginning based on the transmission heterogeneity (overdispersion) of severe acute respiratory coronavirus 2 (SARS-CoV-2). However, studies analyzing overdispersion of transmission among new variants of concerns (VOCs), especially for Omicron, were limited. Thus, we aimed to clarify how the transmission heterogeneity has changed with the emergence of VOCs (Alpha, Delta, and Omicron) using detailed contact tracing data in Yamagata Prefecture, Japan. We estimated the time-varying dispersion parameter ([Formula: see text]) by fitting a negative binomial distribution for each transmission generation. Our results showed that even after the emergence of VOCs, there was transmission heterogeneity of SARS-CoV-2, with changes in [Formula: see text] during each wave. Continuous monitoring of transmission dynamics is vital for implementing appropriate measures. However, a feasible and sustainable epidemiological analysis system should be established to make this possible.
Lack of zoonotic coronavirus species detected among children hospitalized with pneumonia in the Philippines. International-journal

Yusuke Sayama, Michiko Okamoto, Mayuko Saito, Raita Tamaki, Mariko Saito-Obata, Reynaldo Frederick Negosa Quicho, Christina Dahlia Joboco, Socorro Lupisan, Hitoshi Oshitani

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America　2023/07/20

DOI： 10.1093/cid/ciad430 　
Rapid Detection of SARS-CoV-2 RNA Using Reverse Transcription Recombinase Polymerase Amplification (RT-RPA) with Lateral Flow for N-Protein Gene and Variant-Specific Deletion-Insertion Mutation in S-Protein Gene. International-journal

Jose L Malaga, Monica J Pajuelo, Michiko Okamoto, Emmanuel Kagning Tsinda, Kanako Otani, Pablo Tsukayama, Lucero Mascaro, Diego Cuicapuza, Masamichi Katsumi, Kazuhisa Kawamura, Hidekazu Nishimura, Akie Sakagami, Yo Ueki, Suguru Omiya, Satoshi Okamoto, Asami Nakayama, Shin-Ichi Fujimaki, Chuyao Yu, Sikandar Azam, Eiichi Kodama, Clyde Dapat, Hitoshi Oshitani, Mayuko Saito

Viruses　15　(6)　2023/05/26

DOI： 10.3390/v15061254 　

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Rapid molecular testing for severe acute respiratory coronavirus 2 (SARS-CoV-2) variants may contribute to the development of public health measures, particularly in resource-limited areas. Reverse transcription recombinase polymerase amplification using a lateral flow assay (RT-RPA-LF) allows rapid RNA detection without thermal cyclers. In this study, we developed two assays to detect SARS-CoV-2 nucleocapsid (N) gene and Omicron BA.1 spike (S) gene-specific deletion-insertion mutations (del211/ins214). Both tests had a detection limit of 10 copies/µL in vitro and the detection time was approximately 35 min from incubation to detection. The sensitivities of SARS-CoV-2 (N) RT-RPA-LF by viral load categories were 100% for clinical samples with high (>9015.7 copies/µL, cycle quantification (Cq): < 25) and moderate (385.5-9015.7 copies/µL, Cq: 25-29.9) viral load, 83.3% for low (16.5-385.5 copies/µL, Cq: 30-34.9), and 14.3% for very low (<16.5 copies/µL, Cq: 35-40). The sensitivities of the Omicron BA.1 (S) RT-RPA-LF were 94.9%, 78%, 23.8%, and 0%, respectively, and the specificity against non-BA.1 SARS-CoV-2-positive samples was 96%. The assays seemed more sensitive than rapid antigen detection in moderate viral load samples. Although implementation in resource-limited settings requires additional improvements, deletion-insertion mutations were successfully detected by the RT-RPA-LF technique.
Transmission of COVID-19 in Nightlife, Household, and Health Care Settings in Tokyo, Japan, in 2020

Takeaki Imamura, Aika Watanabe, Yusuke Serizawa, Manami Nakashita, Mayuko Saito, Mayu Okada, Asamoe Ogawa, Yukiko Tabei, Yoshiko Soumura, Yoko Nadaoka, Naoki Nakatsubo, Takashi Chiba, Kenji Sadamasu, Kazuhisa Yoshimura, Yoshihiro Noda, Yuko Iwashita, Yuji Ishimaru, Naomi Seki, Kanako Otani, Tadatsugu Imamura, Matthew Myers Griffith, Kelly DeToy, Motoi Suzuki, Michihiko Yoshida, Atsuko Tanaka, Mariko Yauchi, Tomoe Shimada, Hitoshi Oshitani

JAMA Network Open　6　(2)　e230589-e230589　2023/02/24
Publisher: American Medical Association (AMA)
DOI： 10.1001/jamanetworkopen.2023.0589 　

eISSN： 2574-3805

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Importance There have been few studies on the heterogeneous interconnection of COVID-19 outbreaks occurring in different social settings using robust, surveillance epidemiological data. Objectives To describe the characteristics of COVID-19 transmission within different social settings and to evaluate settings associated with onward transmission to other settings. Design, Setting, and Participants This is a case series study of laboratory-confirmed COVID-19 cases in Tokyo between January 23 and December 5, 2020, when vaccination was not yet implemented. Using epidemiological investigation data collected by public health centers, epidemiological links were identified and classified into 7 transmission settings: imported, nightlife, dining, workplace, household, health care, and other. Main Outcomes and Measures The number of cases per setting and the likelihood of generating onward transmissions were compared between different transmission settings. Results Of the 44 054 confirmed COVID-19 cases in this study, 25 241 (57.3%) were among male patients, and the median (IQR) age of patients was 36 (26-52) years. Transmission settings were identified in 13 122 cases, including 6768 household, 2733 health care, and 1174 nightlife cases. More than 6600 transmission settings were detected, and nightlife (72 of 380 [18.9%]; P &amp;lt; .001) and health care (119 [36.2%]; P &amp;lt; .001) settings were more likely to involve 5 or more cases than dining, workplace, household, and other settings. Nightlife cases appeared in the earlier phase of the epidemic, while household and health care cases appeared later. After adjustment for transmission setting, sex, age group, presence of symptoms, and wave, household and health care cases were less likely to generate onward transmission compared with nightlife cases (household: adjusted odds ratio, 0.03; 95% CI, 0.02-0.05; health care: adjusted odds ratio, 0.57; 95% CI, 0.41-0.79). Household settings were associated with intergenerational transmission, while nonhousehold settings mainly comprised transmission between the same age group. Among 30 932 cases without identified transmission settings, cases with a history of visiting nightlife establishments were more likely to generate onward transmission to nonhousehold settings (adjusted odds ratio, 5.30 [95% CI, 4.64-6.05]; P &amp;lt; .001) than those without such history. Conclusions and Relevance In this case series study, COVID-19 cases identified in nightlife settings were associated with a higher likelihood of spreading COVID-19 than household and health care cases. Surveillance and interventions targeting nightlife settings should be prioritized to disrupt COVID-19 transmission, especially in the early stage of an epidemic.
Seroprevalence of four endemic human coronaviruses and, reactivity and neutralization capability against SARS-CoV-2 among children in the Philippines. International-journal

Yusuke Sayama, Michiko Okamoto, Mayuko Saito, Mariko Saito-Obata, Raita Tamaki, Christine Dahlia Joboco, Socorro Lupisan, Hitoshi Oshitani

Scientific reports　13　(1)　2310-2310　2023/02/09

DOI： 10.1038/s41598-023-29072-3 　

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Four endemic human coronaviruses (HCoV), HCoV-229E, HCoV-NL63, HCoV-HKU1, and HCoV-OC43, are closely related to SARS-CoV-2. These coronaviruses are known to infect humans living in temperate areas, including children under 5 years old; however, the seroprevalence of four HCoVs among children in tropical areas, including the Philippines, remains unclear. This study aimed to assess the prevalence of antibodies against four HCoVs and to determine the reactivity and neutralization of these antibodies against SARS-CoV-2 among children in the Philippines. A total of 315 serum samples collected from 2015 to 2018, before the emergence of SARS-CoV-2, in Biliran island, Philippines, were tested for the presence of antibodies against four HCoVs and SARS-CoV-2 using recombinant spike ectodomain proteins by IgG-enzyme-linked immunosorbent assay (ELISA). Reactivity to and neutralization of SARS-CoV-2 were also investigated. The seroprevalence of the four HCoVs was 63.8% for HCoV-229E, 71.4% for HCoV-NL63, 76.5% for HCoV-HKU1, and 83.5% for HCoV-OC43 by ELISA. Age group analysis indicated that seropositivity to all HCoVs reached 80% by 2-3 years of age. While 69/315 (21.9%) of the samples showed reactive to SARS-CoV-2, almost no neutralization against SARS-CoV-2 was detected using neutralization assay. Reactivity of antibodies against SARS-CoV-2 spike protein obtained by ELISA may not correlate with neutralization capability.
【新型コロナウイルスと闘う最前線】COVID-19の疫学的特徴と自治体公開情報を用いた解析

今村剛朗, 仁宮洸太, 押谷仁

BIO Clinica　37　(13)　1168-1172　2022/12
Publisher: (株)北隆館
ISSN： 0919-8237
A multinational Delphi consensus to end the COVID-19 public health threat. International-journal

Jeffrey V Lazarus, Diana Romero, Christopher J Kopka, Salim Abdool Karim, Laith J Abu-Raddad, Gisele Almeida, Ricardo Baptista-Leite, Joshua A Barocas, Mauricio L Barreto, Yaneer Bar-Yam, Quique Bassat, Carolina Batista, Morgan Bazilian, Shu-Ti Chiou, Carlos Del Rio, Gregory J Dore, George F Gao, Lawrence O Gostin, Margaret Hellard, Jose L Jimenez, Gagandeep Kang, Nancy Lee, Mojca Matičič, Martin McKee, Sabin Nsanzimana, Miquel Oliu-Barton, Bary Pradelski, Oksana Pyzik, Kenneth Rabin, Sunil Raina, Sabina Faiz Rashid, Magdalena Rathe, Rocio Saenz, Sudhvir Singh, Malene Trock-Hempler, Sonia Villapol, Peiling Yap, Agnes Binagwaho, Adeeba Kamarulzaman, Ayman El-Mohandes

Nature　611　(7935)　332-345　2022/11

DOI： 10.1038/s41586-022-05398-2 　

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Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches1, while maintaining proven prevention measures using a vaccines-plus approach2 that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities3 in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.
Comparison of Rhinovirus A-, B-, and C-Associated Respiratory Tract Illness Severity Based on the 5'-Untranslated Region Among Children Younger Than 5 Years. International-journal

Akiko Sayama, Michiko Okamoto, Raita Tamaki, Mariko Saito-Obata, Mayuko Saito, Taro Kamigaki, Yusuke Sayama, Irene Lirio, Joanna Ina G Manalo, Veronica L Tallo, Socorro P Lupisan, Hitoshi Oshitani

Open forum infectious diseases　9　(10)　ofac387　2022/10

DOI： 10.1093/ofid/ofac387 　

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BACKGROUND: Rhinoviruses (RVs) are among the most frequently detected viruses from hospitalized children with severe acute respiratory infections, being classified into RV-A, RV-B, and RV-C (4 clades: C, GAC1, GAC2, and A2). This study aimed to compare the clinical characteristics and respiratory tract illness severity between the RV species and RV-C clades in children in primary care and hospital settings in rural communities in the Philippines. METHODS: Clinical samples and information of children <5 years old in the Philippines were collected from 2014 to 2016. The samples were tested by reverse-transcription polymerase chain reaction (RT-PCR) targeting the 5'-untranslated region. PCR-positive samples were sequenced, and RV species were identified by phylogenetic analysis. RESULTS: Overall, 3680 respiratory tract illness episodes in 1688 cohort children were documented; 713 of those were RV positive and identified as RV-A (n = 271), RV-B (n = 47), and RV-C (n = 395: C [n = 76], GAG1 [n = 172], GAG2 [n = 8], A2 [n = 138], and unidentified [n = 1]). Severe illnesses, low oxygen saturation, cough, and wheezing were more common in patients with RV-C, especially with GAC1, than in those with RV-A or RV-B. Furthermore, severe illness was significantly more common in RV-C (GAC1)-positive cases than in RV-A-positive cases (odds ratio, 2.61 [95% CI, 1.17-4.13]). CONCLUSIONS: Children infected with RV-C had more severe illnesses than children infected with RV-A and RV-B. Moreover, emerging clades of RV-C were associated with increased severity.
Japanese encephalitis virus genotype III from mosquitoes in Tarlac, Philippines. International-journal

Wilfredo E Aure, Yusuke Sayama, Mariko Saito-Obata, Nelia P Salazar, Fedelino F Malbas Jr, Hazel O Galang, Tadatsugu Imamura, Cecilia L Zuasula, Hitoshi Oshitani

IJID regions　4　59-65　2022/09

DOI： 10.1016/j.ijregi.2022.05.005 　

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OBJECTIVES: The aim of this study was to investigate the presence of Japanese encephalitis virus (JEV) in a rice-farming community in the Philippines and to determine its implications regarding the epidemiology of viral encephalitides in the Asia-Pacific Region. METHODS: Mosquitoes were collected monthly from animal-baited traps close to flooded rice fields in two barangays (villages) in the Municipality of San Jose, Tarlac Province in Luzon, from May 2009 to July 2010. Virus was detected by nested reverse transcription PCR. Phylogenetic analysis of the amplified virus envelope gene was done using the maximum-likelihood method. RESULTS: A total of 28 700 known vector mosquitoes were collected, namely Culex vishnui, Culex fuscocephala, Culex tritaeniorhynchus, and Culex gelidus. JEV genotype III was detected in C. tritaeniorhynchus, belonging to the same genotype but form a different clade from those reported in the 1980s and in 2020 in this country. CONCLUSIONS: Japanese encephalitis is associated with rice cultivation and the presence of infected mosquitoes in Tarlac, Philippines. It remains to be seen whether the observed genetic shift of genotype III to genotype I in Asia will in time have an impact on the epidemiology of Japanese encephalitis in the Philippines. For long-term disease control, regular surveillance and Japanese encephalitis immunization in children and travelers in high risk areas are recommended.
Epidemiological Factors Associated with COVID-19 Clusters in Medical and Social Welfare Facilities.

Tadatsugu Imamura, Yura K Ko, Yuki Furuse, Takeaki Imamura, Kazuaki Jindai, Reiko Miyahara, Eiichiro Sando, Ikkoh Yasuda, Naho Tsuchiya, Mayuko Saito, Motoi Suzuki, Hitoshi Oshitani

Japanese journal of infectious diseases　75　(3)　281-287　2022/05/24

DOI： 10.7883/yoken.JJID.2021.288 　

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The characteristics of coronavirus disease 2019 (COVID-19) clusters in medical and social welfare facilities and the factors associated with cluster size are still not yet fully understood. We reviewed COVID-19 cases in Japan identified from January 15 to April 30, 2020 and analyzed the factors associated with cluster size in medical and social welfare facilities. In this study, COVID-19 clusters were identified in 56 medical and 34 social welfare facilities. The number of cases in those facilities peaked after the peak of the general population. The duration of occurrence of new cases in clusters was positively correlated with the number of cases in both types of facilities (rho = 0.44, P < 0.001; and rho = 0.69, P < 0.001, respectively). However, the number of days between the first case in a prefecture and the onset of clusters was negatively correlated with the number of cases only in clusters in social welfare facilities (rho = - 0.4, P = 0.004). Our results suggest that COVID-19 cases in those facilities were prevalent in the latter phase of the disease's community transmission, although the underlying mechanisms for such a trend could differ between medical and social welfare facilities.
COVID lessons from Japan: the right messaging empowers citizens. International-journal

Hitoshi Oshitani

Nature　605　(7911)　589-589　2022/05

DOI： 10.1038/d41586-022-01385-9 　
Prolonged shedding of infectious viruses with haplotype switches of SARS-CoV-2 in an immunocompromised patient. International-journal

Kosuke Shoji, Akira Suzuki, Michiko Okamoto, Emmanuel Kagning Tsinda, Naoko Sugawara, Mie Sasaki, Yoshihiko Nogami, Michio Kobayashi, Hitoshi Oshitani, Masaru Yanai

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　28　(7)　1001-1004　2022/04/07

DOI： 10.1016/j.jiac.2022.04.004 　

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A concern has been raised that the persistent COVID-19 infection in an immunocompromised host can be the source of the SARS-CoV-2 variants. This is the case of a 61-year-old man in complete remission of a follicular lymphoma after six cycles of rituximab and bendamustine with additional two cycles of rituximab completed eight months prior to the episode of COVID-19 pneumonia. The patient's respiratory failure was long-lasting, and required mechanical ventilation until day 75. Acquired immunity tested negative throughout the observational period. The viral RNA was detectable until day 100 while the infectious virus was isolated until day 79. Seven haplotypes were identified and the non-synonymous mutations accumulated in the spike gene which included E484Q and S494P. In the management of COVID-19 cases with suppressed immune statuses, initial evaluation of existing immunity and monitoring for infectiousness throughout the clinical course including the convalescent stage may be necessary.
Serotype Identification of Human Adenoviruses Associated with Influenza-Like Illnesses in the Philippines from 2006-2012 by Microneutralization and Molecular Techniques. International-journal

Catherine Calzado-Dacasin, Janiza Lianne Foronda, Vina Lea Arguelles, Chona Mae Daga, Marie Therese Quimpo, Socorro Lupisan, Clyde Dapat, Mariko Saito, Michiko Okamoto, Pia Marie Albano, Hitoshi Oshitani

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases　117　326-333　2022/04

DOI： 10.1016/j.ijid.2022.02.008 　

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OBJECTIVES: Human adenoviruses (HAdV) are known to cause a wide range of diseases including acute respiratory infections, conjunctivitis, and acute gastroenteritis. In this study, we aimed to determine the serotypes of HAdV in patients with influenza-like illness (ILI) in the Philippines from 2006-2012 and to describe the demographic and epidemiological characteristics of patients who tested positive for HAdV. METHODS: Between 2006 and 2012, the Philippine National Influenza Centre detected HAdV in 1294 samples of patients with ILI. Serotype determination was done in select samples using microneutralization, polymerase chain reaction (PCR), and sequencing methods. RESULTS: A total of 8 serotypes were identified (HAdV 1-7 and 11), with HAdV-2 (27.8%), and HAdV-3 (27.8%) being the most prevalent. The majority of HAdV infections were found in children below 5 years of age (79.9%). CONCLUSIONS: The identification of HAdV circulating serotypes may serve as guide for designing disease intervention and control strategies and will provide important information regarding the contribution of this virus to respiratory infections, particularly in children, which remain a public health burden in the Philippines.
Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines. International-journal

Kanako Otani, Mayuko Saito, Michiko Okamoto, Raita Tamaki, Mariko Saito-Obata, Taro Kamigaki, Irene C Lirio, Edelwisa Segubre-Mercado, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani

BMC infectious diseases　22　(1)　313-313　2022/03/30

DOI： 10.1186/s12879-022-07289-3 　

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BACKGROUND: Lower respiratory tract infection (LRTI) is an important cause of morbidity and mortality in infants and young children. However, the etiological role of viruses and the timing of developing LRTI are not well defined. METHODS: We analyzed the data of a prospective cohort study in the Philippines as a birth cohort. We detected LRTI among children who visited healthcare facilities with respiratory symptom, and collected nasopharyngeal swabs for virus detection. We analyzed the incidence rates (IRs) and cumulative proportion of LRTI and severe LRTI by age group and each virus detected. RESULTS: A total of 350 LRTI episodes were observed from 473 child-years yielded from 419 children. The IRs of LRTI were 70.8, 70.7, and 80.8 per 100 child-years for 0-5, 6-11, and 12-23 months of age, respectively. By 12 months of age, 45% of children developed LRTI at least once. Rhinovirus and respiratory syncytial virus were the most frequently detected viruses in all age groups. However, the IRs of influenza virus were low especially at 0-5 months of age. CONCLUSIONS: We identified various patterns of age-specific IRs of LRTI and severe LRTI for different viruses, which should be considered to establish more effective interventions including vaccinations.
Incidence and length of outbreak period of COVID-19 and population density in comparison with seasonal influenza in Japan. International-journal

Hiroki Akaba, Kazuaki Jindai, Yugo Shobugawa, Hitoshi Oshitani

IJID regions　2　154-157　2022/03

DOI： 10.1016/j.ijregi.2022.01.003 　

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OBJECTIVES: There is no consensus regarding the impact of population density on the transmission of respiratory viral infections such as COVID-19 and seasonal influenza. Our study aimed to determine the correlation between population density and the incidence and duration of COVID-19 transmission. METHODS: Publicly available data for confirmed COVID-19 cases in Japan, from January 2020 through November 2021, were retrospectively collected. The average numbers of seasonal influenza cases reported in the national database from 2013-2014 through 2019-2020 were identified. Using data for COVID-19 and seasonal influenza population density and incidence rates (age-adjusted), the Pearson's correlation coefficient was determined. RESULTS: A significant positive correlation between log population density and length of outbreak period was observed for COVID-19 (r = 0.734; p < 0.001) but not for seasonal influenza. Additionally, a significant linear correlation was observed between population density and age-adjusted incidence rate for COVID-19 (r = 0.692; p < 0.001) but not for seasonal influenza. CONCLUSIONS: In Japan, areas with high population density experienced a prolonged and more intense COVID-19 outbreak compared with areas with low population density. This was not observed with seasonal influenza, suggesting that public health measures against COVID-19 should be tailored according to population density.
Secondary transmission of SARS-CoV-2 during the first two waves in Japan: Demographic characteristics and overdispersion

Yura K Ko, Yuki Furuse, Kota Ninomiya, Kanako Otani, Hiroki Akaba, Reiko Miyahara, Tadatsugu Imamura, Takeaki Imamura, Alex R Cook, Mayuko Saito, Motoi Suzuki, Hitoshi Oshitani

International Journal of Infectious Diseases　116　365-373　2022/03
Publisher: Elsevier BV
DOI： 10.1016/j.ijid.2022.01.036 　

ISSN： 1201-9712
Integration of publicly available case-based data for real-time coronavirus disease 2019 risk assessment, Japan. International-journal

Kota Ninomiya, Mariko Kanamori, Naomi Ikeda, Kazuaki Jindai, Yura K Ko, Kanako Otani, Yuki Furuse, Hiroki Akaba, Reiko Miyahara, Mayuko Saito, Motoi Suzuki, Hitoshi Oshitani

Western Pacific surveillance and response journal : WPSAR　13　(1)　1-6　2022

DOI： 10.5365/wpsar.2022.13.1.889 　

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In response to the outbreak of coronavirus disease 2019 (COVID-19) in Japan, a national COVID-19 cluster taskforce (comprising governmental and nongovernmental experts) was established to support the country's Ministry of Health, Labour and Welfare in conducting daily risk assessment. The assessment was carried out using established infectious disease surveillance systems; however, in the initial stages of the pandemic these were not sufficient for real-time risk assessment owing to limited accessibility, delay in data entry and inadequate case information. Also, local governments were publishing anonymized data on confirmed COVID-19 cases on their official web sites as daily press releases. We developed a unique database for nationwide real-time risk assessment that included these case lists from local government web sites and integrated all case data into a standardized format. The database was updated daily and checked systematically to ensure comprehensiveness and quality. Between 15 January 2020 and 15 June 2021, 776 459 cases were logged in the database, allowing for analysis of real-time risk from the pandemic. This semi-automated database was used in daily risk assessments, and to evaluate and update control measures to prevent community transmission of COVID-19 in Japan. The data were reported almost every week to the Japanese Government Advisory Panel on COVID-19 for public health responses.
Near-Complete Genome Sequencing of Influenza C Virus in the Philippines between 2014 and 2019. International-journal

Daisetsu Fujita, Clyde Dapat, Emmanuel Kagning Tsinda, Mayuko Saito, Michiko Okamoto, Mariko Saito-Obata, Beatriz P Quiambao, Socorro P Lupisan, Hitoshi Oshitani

Microbiology resource announcements　10　(49)　e0090021　2021/12/09

DOI： 10.1128/MRA.00900-21 　

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We report 19 nearly complete genome sequences of influenza C virus isolated from clinical samples recovered from children in the Philippines between 2014 and 2019.
Molecular characterization of Vibrio cholerae O1 isolates obtained from outbreaks in the Philippines, 2015-2016. International-journal

Mark Philip Bugayong, Hidemasa Izumiya, Josie M Bilar, Masatomo Morita, Eiji Arakawa, Mariko Saito-Obata, Hitoshi Oshitani, Makoto Ohnishi

Journal of medical microbiology　70　(11)　2021/11

DOI： 10.1099/jmm.0.001443 　

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Introduction. The Philippines, comprising three island groups, namely, Luzon, Visayas and Mindanao, experienced an increase in cholera outbreaks in 2016. Previous studies have shown that Vibrio cholerae isolates obtained from the Philippines are novel hybrid El Tor strains that have evolved in the country and are clearly distinct from those found in Mozambique and Cameroon.Gap statement. The characterization of the strains isolated from outbreaks has been limited to phenotypic characteristics, such as biochemical and serological characteristics, in most previous studies.Aim. We performed multilocus variable-number tandem repeat (VNTR) analysis (MLVA) for V. cholerae isolates obtained from 2015 to 2016 to further characterize and understand the emergence and dissemination of the strains in the Philippines.Methodology. A total of 139 V. cholerae O1 Ogawa biotype El Tor isolates were obtained from the Philippines during diarrhoeal outbreaks in 18 provinces between 2015 and 2016. VNTR data were analysed to classify the MLVA profiles where the large-chromosome types (LCTs) were applied for grouping.Results. We identified 50 MLVA types among 139 isolates originating from 18 provinces, and 14 LCTs. The distribution of the LCTs was variable, and a few were located in specific areas or even in specific provinces. Based on eBURST analysis, 99 isolates with 7 LCTs and 32 MLVA types belonged to 1 group, suggesting that they were related to each other. LCT A was predominant (n=67) and was isolated from Luzon and Visayas. LCT A had 14 MLVA types; however, it mostly emerged during a single quarter of a year. Eight clusters were identified, each of which involved specific MLVA type(s). The largest cluster involved 23 isolates showing 3 MLVA types, 21 of which were MLVA type A-14 isolated from Negros Occidental during quarter 4 of 2016. Comparative analysis showed that almost all isolates from the Philippines were distinct from those in other countries.Conclusions. The genotypic relationship of the V. cholerae isolates obtained during outbreaks in the Philippines was studied, and their emergence and dissemination were elucidated. MLVA revealed the short-term dynamics of V. cholerae genotypes in the Philippines.
Facilitating the deployment of Japanese human resources for responding global outbreaks of emerging and Re-emerging infectious diseases: A cross-sectional study

Hidetoshi Nomoto, Masahiro Ishikane, Sangnim Lee, Nobuhiro Komiya, Takahiro Maeki, Tamano Matsui, Kouichi Morita, Hitoshi Oshitani, Masayuki Saijo, Takuya Yamagishi, Taro Yamamoto, Norio Ohmagari

Journal of Infection and Chemotherapy　2021/10
Publisher: Elsevier BV
DOI： 10.1016/j.jiac.2021.09.015 　

ISSN： 1341-321X
Proactive Engagement of the Expert Meeting in Managing the Early Phase of the COVID-19 Epidemic, Japan, February-June 2020. International-journal

Tomoya Saito, Kaori Muto, Mikihito Tanaka, Nobuhiko Okabe, Hitoshi Oshitani, Satoshi Kamayachi, Yoshihiro Kawaoka, Akihiko Kawana, Motoi Suzuki, Kazuhiro Tateda, Hitomi Nakayama, Masaki Yoshida, Akifumi Imamura, Fumio Ohtake, Norio Ohmagari, Ken Osaka, Mitsuo Kaku, Tomimasa Sunagawa, Kazutoshi Nakashima, Hiroshi Nishiura, Koji Wada, Shigeru Omi, Takaji Wakita

Emerging infectious diseases　27　(10)　1-9　2021/10

DOI： 10.3201/eid2710.204685 　

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To deal with the risk of emerging diseases with many unknowns, close and timely collaboration and communication between science experts and policymakers are crucial to developing and implementing an effective science-based intervention strategy. The Expert Meeting, an ad hoc medical advisory body, was established in February 2020 to advise Japan's COVID-19 Response Headquarters. The group played an important role in the policymaking process, promoting timely situation awareness and developing science-based proposals on interventions that were promptly reflected in government actions. However, this expert group may have been overly proactive in taking on the government's role in crisis management. For the next stage of managing the coronavirus disease pandemic and future pandemics, the respective roles of the government and its advisory bodies need to be clearly defined. Leadership and strategic risk communication by the government are key.
Complete Genome Sequences of Enterovirus D68 Clade A and D Strains in the Philippines. International-journal

Michiko Okamoto, Masahiro Sakamoto, Clyde Dapat, Mayuko Saito, Mariko Saito-Obata, Raita Tamaki, Socorro P Lupisan, Beatriz P Quiambao, Hitoshi Oshitani

Microbiology resource announcements　10　(39)　e0070921　2021/09/30

DOI： 10.1128/MRA.00709-21 　

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Complete genome sequences were determined for 4 clade A and 12 clade D enterovirus D68 strains detected in nasopharyngeal swabs from children with acute respiratory illness in the Philippines. These sequence data will be useful for future epidemiological monitoring, including watching for viral evolution.
COVID-19 case-clusters and transmission chains in the communities in Japan

Yiiki Furuse, Naho Tsnchiya, Reiko Miyahara, Dckoh Yasuda, Eiichiro Sando, Yura K Ko, Takeaki Imainura, Konosiike Morimoto, Tadatsugu Iinamura, Yugo Shobugawa, Shohei Nagata, Atsuna Tokiimoto, Kazuaki Jiiidai, Motoi Suzuki, Hitoshi Oshitani

Journal of Infection　2021/08
Publisher: Elsevier BV
DOI： 10.1016/j.jinf.2021.08.016 　

ISSN： 0163-4453
Risk of Transmission and Viral Shedding from the Time of Infection for Respiratory Syncytial Virus in Households

Hirono Otomaru, Johanna Beulah T Sornillo, Taro Kamigaki, Samantha Louise P Bado, Michiko Okamoto, Mariko Saito-Obata, Marianette T Inobaya, Edelwisa Segubre-Mercado, Portia P Alday, Mayuko Saito, Veronica L Tallo, Beatriz P Quiambao, Hitoshi Oshitani, Alex R Cook

American Journal of Epidemiology　2021/07/03
Publisher: Oxford University Press (OUP)
DOI： 10.1093/aje/kwab181 　

ISSN： 0002-9262

eISSN： 1476-6256

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<title>Abstract</title> Respiratory Syncytial Virus (RSV) is a leading cause of lower respiratory tract infection worldwide. The report of temporal changes in the risk of transmission among close contacts has been scarce. This study aims to examine an association between the viral load trajectory and transmission risk to develop a better control strategy for the disease spread. We conducted a household-based prospective cohort study in Biliran Province, the Philippines, and enrolled 451 participants for observing the development of acute respiratory infection. Including the cases found at the health care facility, we analyzed the data of viral loads with symptom records obtained from 172 followed-up participants whose household member was RSV positive with a rapid test during an RSV outbreak in 2018–2019. We developed a model estimating a temporal change of the viral shedding from the infection and evaluated transmission dynamics. We revealed that most transmission events occurred within approximately 7 days from the household exposure, including potential pre-symptomatic transmissions. The inferred risk of infection among those younger than 5 years old was 3.5 times higher than that of those older than 5 years. This finding suggested that the initial week after the household exposure is particularly important for preventing RSV spread.
Relationship of test positivity rates with covid‐19 epidemic dynamics

Yuki Furuse, Yura K. Ko, Kota Ninomiya, Motoi Suzuki, Hitoshi Oshitani

International Journal of Environmental Research and Public Health　18　(9)　2021/05/01

DOI： 10.3390/ijerph18094655 　

ISSN： 1661-7827

eISSN： 1660-4601
日本からの国際感染症危機対応への派遣促進因子に関するアンケート調査

野本英俊, 石金正裕, 古宮伸洋, 森田公一, 押谷仁, 西條政幸, 山岸拓也, 大曲貴夫

感染症学雑誌　95　(臨増)　316-316　2021/04
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
日本からの国際感染症危機対応への派遣促進因子に関するアンケート調査

野本英俊, 石金正裕, 古宮伸洋, 森田公一, 押谷仁, 西條政幸, 山岸拓也, 大曲貴夫

感染症学雑誌　95　(臨増)　316-316　2021/04
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
Familial clusters of coronavirus disease in 10 prefectures, japan, february-may 2020

Reiko Miyahara, Naho Tsuchiya, Ikkoh Yasuda, Yura K. Ko, Yuki Furuse, Eiichiro Sando, Shohei Nagata, Tadatsugu Imamura, Mayuko Saito, Konosuke Morimoto, Takeaki Imamura, Yugo Shobugawa, Hiroshi Nishiura, Motoi Suzuki, Hitoshi Oshitani

Emerging Infectious Diseases　27　(3)　915-918　2021/03

DOI： 10.3201/eid2703.203882 　

ISSN： 1080-6040

eISSN： 1080-6059
Inactivation of SARS-CoV-2 by Catechins from Green Tea.

Hidekazu Nishimura, Michiko Okamoto, Isolde Dapat, Masanori Katumi, Hitoshi Oshitani

Japanese journal of infectious diseases　2021/01/29

DOI： 10.7883/yoken.JJID.2020.902 　

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Green tea extracts effectively inactivated SARS-CoV-2 in vitro in a dose-dependent manner. Serially 10-fold diluted solutions of catechin mixture reagent from green tea were mixed with the viral culture fluid at a volume ratio of nine to one, respectively, and kept at room temperature for 5 min. The solution of 10 mg/mL catechin reagent reduced the viral titer by 4.2 log and 1.0 mg/mL solution reduced only by one log. Pre-infection treatment of the cells with the reagent alone did not affect the viral growth. In addition, cells treated with only the reagent was assayed for host-cell viability using the WST-8 system and almost no host-cell damage by the treatment was observed. These findings suggested that the direct treatment of virus with the reagent before inoculation decreased the viral activity and that catechins might have a potential to suppress the SARS-CoV-2 infection.
Roles of Children and Adolescents in COVID-19 Transmission in the Community: A Retrospective Analysis of Nationwide Data in Japan. International-journal

Tadatsugu Imamura, Mayuko Saito, Yura K Ko, Takeaki Imamura, Kanako Otani, Hiroki Akaba, Kota Ninomiya, Yuki Furuse, Reiko Miyahara, Eiichiro Sando, Ikkoh Yasuda, Naho Tsuchiya, Motoi Suzuki, Hitoshi Oshitani

Frontiers in pediatrics　9　705882-705882　2021

DOI： 10.3389/fped.2021.705882 　

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Background: Roles of children and adolescents in spreading coronavirus disease 2019 (COVID-19) in the community is not fully understood. Methods: We analyzed the data of 7,758 children and adolescents with COVID-19 and characteristics of secondary transmission generated by these cases using case information published by local governments. Ratio of pediatric and adolescent cases generating secondary transmission was calculated for various social settings. Results: The incidence of COVID-19 was 24.8 cases per 105 population aged between 0 and 9 years, and 59.2 among those aged between 10 and 19 years, which was lower than that among individuals of all age groups (79.6 per 105 population) between January 15 and October 31, 2020. The proportion of cases generating secondary cases was 8.3% among infants and young children in nursery schools and kindergartens, 16% among children and adolescents attending primary schools, 34% among those attending junior high schools, 43% among those attending high schools, 31% among those attending professional training colleges, and 24% in those attending universities. Households were the most common setting for secondary transmission. Conclusion: The risk of generating secondary cases might be limited among pediatric and adolescent cases with COVID-19, especially in settings outside households. Effectiveness of traditional mitigation measures (e.g., school closures) to suppress COVID-19 transmissions should be carefully evaluated.
Gene signature of children with severe respiratory syncytial virus infection

Clyde Dapat, Satoru Kumaki, Hiroki Sakurai, Hidekazu Nishimura, Hannah Karen Mina Labayo, Michiko Okamoto, Mayuko Saito, Hitoshi Oshitani

Pediatric Research　2021

DOI： 10.1038/s41390-020-01347-9 　

ISSN： 0031-3998

eISSN： 1530-0447
Surveillance of dengue virus in individual Aedes aegypti mosquitoes collected concurrently with suspected human cases in Tarlac City, Philippines

Jean Claude Balingit, Thaddeus M. Carvajal, Mariko Saito-Obata, Maribet Gamboa, Amalea Dulcene Nicolasora, Ava Kristy Sy, Hitoshi Oshitani, Kozo Watanabe

Parasites and Vectors　13　(1)　2020/12

DOI： 10.1186/s13071-020-04470-y 　

eISSN： 1756-3305
【新型コロナウイルス感染症(COVID-19)と精神科病院】宮城県精神科医療機関新型コロナウイルス感染症対策ネットワークにおける対策指針策定の経緯と意義コロナ禍が精神医療にもたらした教訓

富田博秋, 佐藤博俊, 角藤芳久, 國井泰人, 佐久間篤, 牧野祐子, 児玉栄一, 徳田浩一, 鈴木陽, 吉田眞紀子, 賀来満夫, 押谷仁, 小坂健

日本精神科病院協会雑誌　39　(11)　1125-1130　2020/11
Publisher: (公社)日本精神科病院協会
ISSN： 1347-4103
【新型コロナウイルス感染症(COVID-19)と精神科病院】宮城県精神科医療機関新型コロナウイルス感染症対策ネットワークにおける対策指針策定の経緯と意義コロナ禍が精神医療にもたらした教訓

富田博秋, 佐藤博俊, 角藤芳久, 國井泰人, 佐久間篤, 牧野祐子, 児玉栄一, 徳田浩一, 鈴木陽, 吉田眞紀子, 賀来満夫, 押谷仁, 小坂健

日本精神科病院協会雑誌　39　(11)　1125-1130　2020/11
Publisher: (公社)日本精神科病院協会
ISSN： 1347-4103
Genetic diversity of species A rotaviruses detected in clinical and environmental samples, including porcine-like rotaviruses from hospitalized children in the Philippines International-journal Peer-reviewed

Toshifumi Imagawa, Mayuko Saito, Dai Yamamoto, Mariko Saito-Obata, Yoshifumi Masago, Adrianne C. Ablola, Amado O. Tandoc, Edelwisa Segubre-Mercado, Socorro P. Lupisan, Hitoshi Oshitani

Infection, Genetics and Evolution　85　104465-104465　2020/11

DOI： 10.1016/j.meegid.2020.104465 　

ISSN： 1567-1348

eISSN： 1567-7257
Norovirus-specific immunoglobulin A in breast milk for protection against norovirus-associated diarrhea among infants. International-journal Peer-reviewed

Hannah Karen Mina Labayo, Monica J Pajuelo, Kentaro Tohma, Lauren A Ford-Siltz, Robert H Gilman, Lilia Cabrera, Holger Mayta, Gerardo J Sanchez, Anniuska Toledo Cornejo, Caryn Bern, Clyde Dapat, Tomonori Nochi, Gabriel I Parra, Hitoshi Oshitani, Mayuko Saito

EClinicalMedicine　27　100561-100561　2020/10

DOI： 10.1016/j.eclinm.2020.100561 　

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Background: Norovirus (NV) causes acute gastroenteritis in infants. Humoral and fecal immunoglobulin A (IgA) responses have been correlated with protection against NV; however, the role of breast milk IgA against NV infection and associated diarrhea is still unknown. This study aimed to evaluate the protective role of NV-specific IgA (NV-IgA) in breast milk. Methods: Ninety-five breast milk samples collected from mothers enrolled in a 2016-2017 Peruvian birth cohort study were tested for total IgA and NV-IgA by ELISA using GII·4 variants and non-GII·4 genotype virus-like particles (VLPs). Breast milk samples were grouped according to the NV infection and diarrheal status of infants: NV positive with diarrhea (NV+D+, n=18); NV positive without diarrhea (NV+D-, n=37); and NV negative without diarrhea (NV-D-, n=40). The percent positivity and titer of NV-IgA were compared among groups. The cross-reactivity was estimated based on the correlation of ratio between NV-IgA against GII·4 variants and non-GII·4 genotype VLPs. Findings: NV-IgA had high positivity rates against different VLPs, especially against GII (89-100%). The NV+D- group had higher percent positivity (89% vs. 61%, p=0·03) and median titer (1:100 vs 1:50, p=0·03) of NV-IgA than the NV+D+ group against GI·1 VLPs. A relatively high correlation between different GII·4 variants (0·87) and low correlation between genogroups (0·23-0·37) were observed. Interpretation: Mothers with high positivity rates and titers of NV-IgA in breast milk had NV infected infants with reduced diarrheal symptoms. Antigenic relatedness to the genetic diversity of human norovirus was suggested.Funding National Institute of Allergy and Infectious Diseases, National Institute of Health: 1R01AI108695-01A1 and the Japan Society for the Promotion of Science (Fostering Joint International Research B):19KK0241.
Epidemiology of COVID-19 Outbreak in Japan, from January-March 2020. Peer-reviewed

Yuki Furuse, Yura K Ko, Mayuko Saito, Yugo Shobugawa, Kazuaki Jindai, Tomoya Saito, Hiroshi Nishiura, Tomimasa Sunagawa, Motoi Suzuki, Hitoshi Oshitani

Japanese journal of infectious diseases　73　(5)　391-393　2020/09/24

DOI： 10.7883/yoken.JJID.2020.271 　
Genetic analysis of sapoviruses detected in outbreaks and sporadic cases of acute gastroenteritis in Miyagi Prefecture, Japan. International-journal Peer-reviewed

Akie Sakagami, Yo Ueki, Clyde Dapat, Mayuko Saito, Hitoshi Oshitani

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology　132　104648-104648　2020/09/19

DOI： 10.1016/j.jcv.2020.104648 　

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BACKGROUND: Human sapovirus (SaV) causes sporadic and endemic acute gastroenteritis worldwide. However, little is known about the relationship between the mode of transmission and genetic characteristics of SaV. OBJECTIVE: To investigate the molecular characteristics of SaV-associated acute gastroenteritis among sporadic cases, foodborne, and nonfoodborne outbreaks. STUDY DESIGN: We performed a systematic review of publications and genetic analysis of SaV in fecal specimens from 98 outpatients with acute gastroenteritis, 32 stool samples from 8 foodborne outbreaks, and 63 stool samples from 23 nonfoodborne outbreaks in Miyagi Prefecture, Japan from 1993 and between 2004 and 2020. Reverse transcription polymerase chain reaction (RT-PCR) was employed for the detection of SaV, and the partial capsid gene was sequenced for genotyping and phylogenetic analysis. RESULTS: The overall detection rate of SaV in sporadic cases, foodborne, and nonfoodborne outbreaks was 5.8, 1.7, and 4.3%, respectively. Genotypic analysis revealed GI.1 to be the predominant genotype in sporadic cases (31.5%) and nonfoodborne outbreaks (52.1%), whereas it was not detected in foodborne outbreaks. Some outbreaks occurred following sporadic cases with the same genotype. CONCLUSIONS: The distribution of SaV genotypes was different between foodborne outbreaks and other settings. The effective SaV infection control may differ depending on the genomic characteristics.
Epidemiological and clinical characteristics of children with acute respiratory viral infections in the Philippines: a prospective cohort study. International-journal Peer-reviewed

Yuki Furuse, Raita Tamaki, Akira Suzuki, Taro Kamigaki, Michiko Okamoto, Mariko Saito-Obata, Emiko Nakagawa, Mayuko Saito, Edelwisa Segubre-Mercado, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases　27　(7)　1037.e9-1037.e14　2020/09/17

DOI： 10.1016/j.cmi.2020.09.017 　

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OBJECTIVES: Viral acute respiratory infection (ARI) remains a major global health problem, especially among children in low- and middle-income countries. The study was conducted to reveal aetiological significance of respiratory viruses among both non-hospitalized and hospitalized children. METHODS: A cohort study of children with ARI at the household, primary healthcare facility, and hospital levels was conducted alongside a hospital-based study including non-cohort children from 2014 to 2016 in the Philippines. The ARI cases were recorded at households and healthcare facilities, and a clinical investigation was performed. Nasopharyngeal swabs were collected from the symptomatic children and tested for respiratory viruses via polymerase chain reaction. Then, the association between healthcare facility utilization and viral detection was investigated. RESULTS: Overall, 18,514 ARI cases were enrolled in the cohort study, and samples were collected from 4735 of these cases. The hospital-based study detected 648 ARI cases, all of which were sampled. Rhinovirus (22.2%; 1052/4735) was most frequently detected followed by respiratory syncytial virus (12.0%; 566/4735). Enterovirus (adjusted odds ratio, 1.8; 95% confidence interval, 1.1-2.8), human metapneumovirus (2.1, 1.4-3.2), rhinovirus (2.1, 1.8-2.6), and respiratory syncytial virus (1.6, 1.2-1.9) were significantly more prevalent in the ARI cases at healthcare facilities than in those in households. Of all ARI cases, 0.6% required hospitalization while 1.8% were hospitalized among the respiratory syncytial virus-positive cases (3.8, 3.0-4.9). CONCLUSIONS: We determined the prevalence of respiratory viruses among children with ARIs at the household, primary healthcare facility, and hospital levels and the association with clinical characteristics. In particular, we discovered a significant disease burden and impact of respiratory syncytial virus infections as well as a considerable aetiological implication of rhinovirus infections.
Clusters of Coronavirus Disease in Communities, Japan, January-April 2020. International-journal Peer-reviewed

Yuki Furuse, Eiichiro Sando, Naho Tsuchiya, Reiko Miyahara, Ikkoh Yasuda, Yura K Ko, Mayuko Saito, Konosuke Morimoto, Takeaki Imamura, Yugo Shobugawa, Shohei Nagata, Kazuaki Jindai, Tadatsugu Imamura, Tomimasa Sunagawa, Motoi Suzuki, Hiroshi Nishiura, Hitoshi Oshitani

Emerging infectious diseases　26　(9)　2176-9　2020/09

DOI： 10.3201/eid2609.202272 　

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We analyzed 3,184 cases of coronavirus disease in Japan and identified 61 case-clusters in healthcare and other care facilities, restaurants and bars, workplaces, and music events. We also identified 22 probable primary case-patients for the clusters; most were 20-39 years of age and presymptomatic or asymptomatic at virus transmission.
Factors affecting mothers' intentions to visit healthcare facilities before hospitalisation of children with pneumonia in Biliran province, Philippines: a qualitative study. International-journal Peer-reviewed

Mari Sato, Hitoshi Oshitani, Raita Tamaki, Nobuko Oyamada, Kineko Sato, Alkaff Raihana Nadra, Jhoys Landicho, Portia P Alday, Socorro P Lupisan, Veronica L Tallo

BMJ open　10　(8)　e036261　2020/08/26

DOI： 10.1136/bmjopen-2019-036261 　

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BACKGROUND AND OBJECTIVES: Despite a substantial reduction in the mortality rate of children under 5 years in the past 25 years, pneumonia remains the single-largest infectious cause of child deaths worldwide. This study explored the chronological order of visited healthcare facilities and practitioners, and the factors affecting mothers' intention to seek care before the hospitalisation of children with pneumonia. METHODS AND ANALYSIS: A qualitative research design was employed using theory of planned behaviour as a framework for the analysis. Using purposive sampling technique, 11 mothers, whose children under 5 years old were hospitalised with severe pneumonia, were recruited for individual semi-structured interviews. Their socio-demographic information was analysed using descriptive statistics. RESULTS: Mothers brought their sick children to multiple facilities, and 1 to 19 days had passed before hospitalisation. We identified four major factors determining mothers' intentions: (1) doing something useful for the sick child, (2) expecting the child to receive the necessary assessment and treatment, (3) accepting advice to visit a healthcare facility and be referred to a hospital and (4) considering issues and benefits associated with hospitalisation. Mothers noticed their children's unusual symptoms and monitored them while applying home remedies. They also took their children to traditional healers despite knowing that the treatments were not necessarily effective. Mothers expected children to be checked by health professionals and listened to advice from family members regarding the facilities to visit, and from healthcare staff to be referred to a hospital. Financial issues and the double burden of housework and caring for the hospitalised child were mothers' major concerns about hospitalisation. CONCLUSION: Children were hospitalised after several days because they visited multiple healthcare facilities, including traditional healers. Improving care quality at healthcare facilities and reducing financial and mothers' burden may reduce the hospitalisation delay for children with pneumonia.
Individual-based dengue virus surveillance in Aedes aegypti mosquitoes collected concurrently with suspected patients in Tarlac City, Philippines Peer-reviewed

Jean Claude Balingit, Thaddeus M. Carvajal, Mariko Saito-Obata, Maribet Gamboa, Amalea Dulcene Nicolasora, Ava Kristy Sy, Hitoshi Oshitani, Kozo Watanabe

2020/08/11
Publisher: Research Square
DOI： 10.21203/rs.3.rs-56950/v1 　

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<title>Abstract</title> Background Dengue virus (DENV) infection continues to be a major public health concern throughout tropical and subtropical regions of the world where Aedes aegypti mosquitoes, its primary vector, dwell. In the context of DENV transmission, effective control is reliant not only on knowledge of mosquito abundance, but also on mosquito infection. In the 2015 dengue season, we conducted a one-month entomological surveillance of adult Aedes aegypti mosquitoes around households of suspected dengue patients in Tarlac City, Philippines to assess the DENV infection rate in the local mosquito population, and to identify the DENV genotypes and serotypes concurrently co-circulating in mosquitoes and patients. Methods We performed a one-step multiplex real-time RT-PCR assay for the simultaneous detection and serotyping of DENV in patients and in individual female Aedes aegypti mosquito. Consequently, we performed sequencing and phylogenetic analyses to further characterize the detected DENVs in mosquitoes and patients at the genotype level. Results We collected a total of 583 adult Aedes aegypti mosquitoes, of which we tested 359 female mosquitoes individually for the presence of the DENV. Ten mosquitoes (2.8%) from amongst 359 female mosquitoes were confirmed to be positive for the presence of the DENV. We detected DENV-1, DENV-2, and DENV-4 in the field-collected mosquitoes, which were consistent with the serotypes concurrently infecting patients. Sequencing and phylogenetic analyses of the detected DENVs based on the partial envelope ( E ) gene revealed three genotypes concurrently present in the sampled mosquitoes and patients during the study period, namely: DENV-1 genotype IV, DENV-2 Cosmopolitan genotype and DENV-4 genotype II. Notably, we observed a random geographic distribution of DENVs in the study area suggesting the occurrence of active DENV transmission within and outside the vicinities of Tarlac City. Conclusions In this study, we demonstrate the utility of an individual-based DENV surveillance in field-collected mosquitoes and the importance of incorporating mosquito virus data in phylogenetic studies. Analyzing virus sequences from vector and host could potentially improve our understanding of the dynamics of DENV transmission.
Association between Numbers of "Imported Cases" and "Reported Cases in a Source Country" of COVID-19: January to April 2020 in Japan. International-journal Peer-reviewed

Yuki Furuse, Hitoshi Oshitani

The Journal of infection　81　(2)　e153-e154　2020/08

DOI： 10.1016/j.jinf.2020.06.005 　
Cluster-based approach to Coronavirus Disease 2019 (COVID-19) response in Japan-February-April 2020. Peer-reviewed

Hitoshi Oshitani

Japanese journal of infectious diseases　73　(6)　491-493　2020/06/30

DOI： 10.7883/yoken.JJID.2020.363 　
Health-seeking practices of caregivers and determinants in responding to acute respiratory infection episodes in Biliran Island, Philippines

Mark Donald C Reñosa, Alvin G Tan, Taro Kamigaki, Raita Tamaki, Jhoys M Landicho, Portia P Alday, Veronica L Tallo, Hitoshi Oshitani

Journal of Global Health Reports　4　2020/04/10
Publisher: Inishmore Laser Scientific Publishing Ltd
DOI： 10.29392/001c.12254 　

eISSN： 2399-1623
Are high-performing health systems resilient against the COVID-19 epidemic? International-journal Peer-reviewed

Helena Legido-Quigley, Nima Asgari, Yik Ying Teo, Gabriel M Leung, Hitoshi Oshitani, Keiji Fukuda, Alex R Cook, Li Yang Hsu, Kenji Shibuya, David Heymann

Lancet (London, England)　395　(10227)　848-850　2020/03/14

DOI： 10.1016/S0140-6736(20)30551-1 　
Fluctuations in Antibody Titers against Enterovirus D68 in Pediatric Sera Collected in a Community before, during, and after a Possible Outbreak. Peer-reviewed

Francois Marie Ngako Kadji, Hidekazu Nishimura, Michiko Okamoto, Ko Sato, Suguru Ohmiya, Hiroko Ito, Akira Suzuki, Yukio Nagai, Hitoshi Oshitani

Japanese journal of infectious diseases　73　(1)　55-57　2020/01/23

DOI： 10.7883/yoken.JJID.2019.056 　

ISSN： 1344-6304

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We previously reported a hospital-based epidemiological study on enterovirus (EV)-D68 infection among children during the autumn of 2015, which indirectly inferred an outbreak in Sendai, Japan. In this study, stocked sera of children (aged 0-6 years; without symptoms of infectious diseases) in the Sendai community collected during 4 periods (1 year before, 6 months before, immediately after, and 1 year after the possible outbreak period) were analyzed using the neutralization antibody titer assay to determine community children's immunity levels against EV-D68 infection. The immunity levels were confirmed to have increased during the possible outbreak period and to have gradually waned over 1 year without another outbreak. These results provide background information supporting the results of our previous hospital-based surveillance study.
Environmental Presence and Genetic Characteristics of Carbapenemase-Producing Enterobacteriaceae from Hospital Sewage and River Water in the Philippines. International-journal Peer-reviewed

Yuki Suzuki, Pearl Joy Nazareno, Ryuichi Nakano, Melisa Mondoy, Akiyo Nakano, Mark Philip Bugayong, Josie Bilar, Mauricio Perez 5th, Emarld Julian Medina, Mariko Saito-Obata, Mayuko Saito, Kazutoshi Nakashima, Hitoshi Oshitani, Hisakazu Yano

Applied and environmental microbiology　86　(2)　2020/01/07

DOI： 10.1128/AEM.01906-19 　

ISSN： 0099-2240

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This study aimed to evaluate the prevalence and genetic characteristics of carbapenemase-producing Enterobacteriaceae (CPE) in hospital sewage and river water in the Philippines, which has a typical tropical maritime climate. We collected 83 water samples from 7 hospital sewage and 10 river water sites. CPE were identified using CHROMagar mSuperCARBA, and Gram-negative strains were identified using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) or 16S rRNA gene sequencing. Resistance genes in Enterobacteriaceae strains were identified using PCR and DNA sequencing, and transferability of carbapenemase genes from the CPE was investigated with conjugation experiments. Genotyping was performed using multilocus sequence typing (MLST) for Escherichia coli and Klebsiella pneumoniae Out of 124 Enterobacteriaceae isolates, we identified 51 strains as CPE and divided these into 7 species, 11 E. coli, 14 Klebsiella spp., 15 Enterobacter spp., and 11 others, including 4 additional species. Conjugation experiments via broth mating and using E. coli J53 revealed that 24 isolates can transfer carbapenemase-encoding plasmids. MLST analysis showed that 6 of 11 E. coli isolates belonged to clonal complex 10 (CC10). Of 11 K. pneumoniae strains, 9 unique sequence types (STs) were identified, including ST147. Five types of carbapenemase genes were identified, with the most prevalent being NDM (n = 39), which is epidemic in clinical settings in the Philippines. E. coli CC10 and K. pneumoniae ST147, which are often detected in clinical settings, were the dominant strains. In summary, our results indicate that hospital sewage and river water are contaminated by CPE strains belonging to clinically important clonal groups.IMPORTANCE Carbapenemase-producing Enterobacteriaceae (CPE) cause severe health care-associated infections, and their increasing prevalence is a serious concern. Recently, natural ecosystems have been recognized as important reservoirs of antibiotic resistance genes. We investigated the prevalence and genetic characteristics of CPE isolated from the environment (hospital sewage and river water) in the Philippines and found several CPE, including Escherichia coli and other species, with different carbapenemases. The most prevalent carbapenemase gene type was NDM, which is endemic in clinical settings. This study revealed that isolates belonging to carbapenemase-producing E. coli CC10 and K. pneumoniae sequence type 147 (ST147), which are often detected in clinical settings, were dominant in the natural environment. Our work here provides a report on the presence and characteristics of CPE in the environment in the Philippines and demonstrates that both hospital sewage and river water are contaminated by CPE strains belonging to clinically important clonal groups.
Receptor-Binding Assays of Enterovirus D68. International-journal Invited Peer-reviewed

Tadatsugu Imamura, Michiko Okamoto, Hitoshi Oshitani

Methods in molecular biology (Clifton, N.J.)　2132　629-639　2020

DOI： 10.1007/978-1-0716-0430-4_54 　

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Human enterovirus D68 (EV-D68) is a causative agent for acute respiratory infections and potentially central nervous system illnesses with increasing epidemiological significance. Recent studies have highlighted the role of sialic acids as a functional receptor for EV-D68 in vitro. However, further investigations are required to reveal its significance in actual infections in human.
Development of a novel in vitro assay to evaluate environmental water using an IL-8 reporter cell line. International-journal

Yutaka Kimura, Chizu Fujimura, Toshifumi Imagawa, Socorro P Lupisan, Mariko Saito-Obata, Mayuko Saito, Hitoshi Oshitani, Setsuya Aiba

EXCLI journal　19　1054-1063　2020

DOI： 10.17179/excli2020-2104 　

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The IL-8 luciferase reporter cell line, THP-G8 cells, used in the in vitro sensitization test, OECD442E, can respond to a variety of stimuli other than haptens, such as lipopolysaccharide (LPS), other bacterial toxins, and detergents. Considering these characteristics, we examined the ability of the IL-8 luciferase assay using THP-G8 cells to evaluate water pollution. We first stimulated THP-G8 cell with various Toll-like receptor (TLR) agonists and nucleotide-binding oligomerization domain-like receptor (NLR) agonists, and found that TLR1, 2, 4, 5, 6 agonists and NOD 1, 2 agonists significantly augmented IL-8 luciferase activity (IL8LA). Then, we examined the detection threshold of LPS by THP-G8 cells, and found it 0.4 EU/ml. Next, we examined whether THP-G8 cells can differently respond to a variety of sources of environmental water around Sendai, Japan and Manila, Philippine and whether there is a correlation between the IL8LA of different sources of water and their level of endotoxin assessed by the LAL assay. There was a clear trend that the IL8LA was lower in the upper stream and higher in the downstream in both Japan and Philippine. Moreover, there was a strong correlation between the IL8LA of the environmental water and its endotoxin level. Finally, using N-acetyl-L-cysteine, an antioxidant/radical scavenger, and polymyxin B that neutralizes endotoxin, we demonstrated that there was a difference in the suppressive effects by them between the water from Japan and that from Philippine. These data suggest the potential of the IL-8 luciferase assay for evaluating environmental water pollution both quantitatively and qualitatively.
Viruses That Can and Cannot Coexist With Humans and the Future of SARS-CoV-2. International-journal Peer-reviewed

Yuki Furuse, Hitoshi Oshitani

Frontiers in microbiology　11　583252-583252　2020

DOI： 10.3389/fmicb.2020.583252 　

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide pandemic. Many projections concerning the outbreak, such as the estimated number of cases and deaths in upcoming months, have been made available. However, what happens to the virus after the pandemic subsides has not been fully explored. In this article, we discuss the ways that past and present human viruses have emerged via zoonotic transmission, the mechanisms that they have acquired the ability for effective transmission among humans, the process to sustain a chain of transmission to coexist with humans, and the factors important for complete containment leading to eradication of viruses. These aspects of viral disease may provide clues for the future path that SARS-CoV-2 might take in relation to human infection.
Potential underestimation of influenza virus burden in infants. International-journal Peer-reviewed

Takeaki Imamura, Mayuko Saito, Hitoshi Oshitani

The Lancet. Child & adolescent health　3　(11)　751-752　2019/11

DOI： 10.1016/S2352-4642(19)30278-0 　

ISSN： 2352-4642
Evolutionary and Functional Diversity of the 5' Untranslated Region of Enterovirus D68: Increased Activity of the Internal Ribosome Entry Site of Viral Strains during the 2010s. International-journal Peer-reviewed

Yuki Furuse, Natthawan Chaimongkol, Michiko Okamoto, Hitoshi Oshitani

Viruses　11　(7)　2019/07/08

DOI： 10.3390/v11070626 　

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The 5' untranslated region (UTR) of the RNA genomes of enteroviruses possesses an internal ribosome entry site (IRES) that directs translation of the mRNA by binding to ribosomes. Infection with enterovirus D68 causes respiratory symptoms and is sometimes associated with neurological disorders. The number of reports of the viral infection and neurological disorders has increased in 2010s, although the reason behind this phenomenon remains unelucidated. In this study, we investigated the evolutionary and functional diversity of the 5' UTR of recently circulating strains of the virus. Genomic sequences of 374 viral strains were acquired and subjected to phylogenetic analysis. The IRES activity of the viruses was measured using a luciferase reporter assay. We found a highly conserved sequence in the 5' UTR and also identified the location of variable sites in the predicted RNA secondary structure. IRES activities differed among the strains in some cell lines, including neuronal and respiratory cells, and were especially high in strains of a major lineage from the recent surge. The effect of mutations in the 5' UTR should be studied further in the future for better understanding of viral pathogenesis.
Age-specific incidence rates and risk factors for respiratory syncytial virus-associated lower respiratory tract illness in cohort children under 5 years old in the Philippines. International-journal Peer-reviewed

Fumihiko Ueno, Raita Tamaki, Mayuko Saito, Michiko Okamoto, Mariko Saito-Obata, Taro Kamigaki, Akira Suzuki, Edelwisa Segubre-Mercado, Hananiah D Aloyon, Veronica Tallo, Socorro P Lupisan, Hitoshi Oshitani

Influenza and other respiratory viruses　13　(4)　339-353　2019/07

DOI： 10.1111/irv.12639 　

ISSN： 1750-2640

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BACKGROUND: Respiratory syncytial virus (RSV) is one of the main viral causes of lower respiratory tract illness (LRTI), especially in young children. RSV vaccines, including maternal and infant vaccines, are under development; however, more epidemiological studies are needed to develop effective vaccination strategies. OBJECTIVES: To estimate detailed age-specific incidence rates and severity of RSV-associated LRTI (RSV-LRTI) using data from a community-based prospective cohort study in the Philippines. PATIENTS/METHODS: Cohort children who visited health facilities due to acute respiratory symptoms were identified, and nasopharyngeal swabs were collected to detect RSV. The severity of RSV-LRTI was assessed using the severity definition proposed by the World Health Organization. Risk factors for developing RSV-LRTI and contribution of SpO2 measurement were also evaluated. RESULTS: A total of 395 RSV episodes which occurred in children aged 2-59 months were categorised as 183 RSV-LRTI, 72 as severe RSV-LRTI and 29 as very severe RSV-LRTI. Children aged 3-5 months had the highest incidence rate of RSV-LRTI, at 207.4 per 1000 child-years (95% CI: 149.0-279.5). Younger age group, place of living and low educational level of caregivers were associated with developing RSV-LRTI. Clinical manifestations had low levels of agreement with hypoxaemia as measured by pulse oximeter. CONCLUSION: The highest burden of RSV was observed in young infants aged 3-5 months, whereas the burden was also high in those aged 12-20 months. Future vaccination strategies should consider the protection of older children, especially those aged one year, as well as young infants.
The association between consuming bivalves, and acute gastroenteritis and norovirus in Tokyo, Japan. International-journal Peer-reviewed

Daiki Kobayashi, Mayuko Saito, Yuji Heike, Kyoko Yokota, Hiroko Arioka, Hitoshi Oshitani

Journal of medical virology　91　(6)　986-996　2019/06

DOI： 10.1002/jmv.25416 　

ISSN： 0146-6615

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A prospective matched case-control study was conducted to evaluate associations between dietary histories, including consumption of bivalves, diarrhea, and norovirus positive diarrhea in adult ambulatory patients at an outpatient clinic of a hospital in Tokyo, Japan. Ambulatory cases with diarrhea were matched with nondiarrheal control patients, who visited the same clinic. A standardized questionnaire was used to obtain patients' information, including histories of food consumption and clinical information. Norovirus infection was confirmed using real-time reverse transcription polymerase chain reaction. A total of 207 patients, including 69 diarrheal cases and 138 nondiarrheal cases were included in the analysis. Among them, 60 (29.0%) participants reported consuming bivalves. Norovirus was detected in 35% (24/69) of diarrheal cases. Of those, 10 (41.7%) reported consumption of bivalves and of those, 6 (60.0%) consumed raw bivalves. The proportion of those who consumed raw bivalves was significantly higher in norovirus-positive diarrheal cases than in norovirus-negative diarrheal cases (25.0% vs 6.7%; odds ratio [OR], 4.67; 95% confidence interval [CI], 1.1-20.7) and matched nondiarrheal controls (25.0% vs 6.3%, OR: 5.00; 95% CI, 1.1-22.2). The attributable fraction of consuming raw bivalves for norovirus-associated diarrhea to matched nondiarrheal controls was 20.0%. Consuming raw bivalves was substantially attributed to norovirus-associated diarrhea in adult ambulatory patients and preventive measures for reducing the risk associated with consumption of raw bivalves could decrease the incidence of norovirus-associated diarrhea.
Molecular characterization of enterovirus-A71 in children with acute flaccid paralysis in the Philippines. International-journal Peer-reviewed

Lea Necitas Apostol, Hiroyuki Shimizu, Akira Suzuki, Rifqiyah Nur Umami, Maria Melissa Ann Jiao, Amado Tandoc 3rd, Mariko Saito, Socorro Lupisan, Hitoshi Oshitani

BMC infectious diseases　19　(1)　370-370　2019/05/02

DOI： 10.1186/s12879-019-3955-x 　

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BACKGROUND: Several inactivated enterovirus-A71 (EV-A71) vaccines are currently licensed in China; however, the development of additional EV-A71 vaccines is ongoing, necessitating extensive analysis of the molecular epidemiology of the virus worldwide. Until 2012, laboratory confirmation of EV-A71 for hand, foot, and mouth disease (HFMD) and other associated diseases had not occurred in the Philippines. Because EV-A71 has been linked with cases of acute flaccid paralysis (AFP), AFP surveillance is one strategy for documenting its possible circulation in the country. To expand current knowledge on EV-A71, molecular epidemiologic analysis and genetic characterization of EV-A71 isolates were performed in this study. METHODS: A retrospective study was performed to identify and characterize nonpolio enteroviruses (NPEVs) associated with AFP in the Philippines, and nine samples were found to be EV-A71-positive. Following characterization of these EV-A71 isolates, the complete viral protein 1 (VP1) gene was targeted for phylogenetic analysis. RESULTS: Nine EV-A71 isolates detected in 2000 (n = 2), 2002 (n = 4), 2005 (n = 2), and 2010 (n = 1) were characterized using molecular methods. Genomic regions spanning the complete VP1 region were amplified and sequenced using specific primers. Phylogenetic analysis of the full-length VP1 region identified all nine EV-A71 Philippine isolates as belonging to the genogroup C lineage, specifically the C2 cluster. The result indicated a genetic linkage with several strains isolated in Japan and Taiwan, suggesting that strains in the C2 cluster identified in the Asia-Pacific region were circulating in the Philippines. CONCLUSION: The study presents the genetic analysis of EV-A71 in the Philippines. Despite some limitations, the study provides additional genetic data on the circulating EV-A71 strains in the Asia-Pacific region, in which information on EV-A71 molecular epidemiology is incomplete. Considering that EV-A71 has a significant public health impact in the region, knowledge of its circulation in each country is important, especially for formulating vaccines covering a wide variety of strains.
Aetiology and risks factors associated with the fatal outcomes of childhood pneumonia among hospitalised children in the Philippines from 2008 to 2016: a case series study. Peer-reviewed

Dembele BPP, Kamigaki T, Dapat C, Tamaki R, Saito M, Saito M, Okamoto M, Igoy MAU, Mercado ES, Mondoy M, Tallo VL, Lupisan SP, Egawa S, Oshitani H

BMJ open　9　(3)　e026895　2019/03

DOI： 10.1136/bmjopen-2018-026895 　
Transmission of Respiratory Syncytial Virus Among Children Under 5 Years in Households of Rural Communities, the Philippines. Peer-reviewed

Otomaru H, Kamigaki T, Tamaki R, Okamoto M, Alday PP, Tan AG, Manalo JI, Segubre-Mercado E, Inobaya MT, Tallo V, Lupisan S, Oshitani H

Open forum infectious diseases　6　(3)　ofz045　2019/03
Publisher: Oxford University Press (OUP)
DOI： 10.1093/ofid/ofz045 　

eISSN： 2328-8957

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Abstract Background To develop a more effective vaccination strategy for reducing the impact of respiratory syncytial virus (RSV) infection, especially in young infants (&lt;6 months old), it is necessary to understand the transmission dynamics of RSV. Methods We conducted a community-based prospective cohort study from 2014 to 2016 in Biliran Province, the Philippines, on children &lt;5 years old. We collected nasopharyngeal swabs from symptomatic children with acute respiratory infection (ARI) during household visits and at health facilities. In households (n = 181) with RSV-positive ARI cases (RSV-ARI), we also identified ARI episodes among other children &lt;5 years old in the same household. In addition, we determined the serial interval to estimate the basic reproduction number (R0), the average number of secondary cases generated by a single primary case. Results In the 181 households analyzed, we found 212 RSV-ARI in 152 households with a single case and 29 households with multiple cases, which included 29 1st RSV-ARI and 31 2nd RSV-ARI. We also found possible index cases among children &lt;5 years old in the same household for 29.0% (18 of 62) of young infants with RSV-ARI. The estimated mean serial interval was 3.2 days, and R0 was estimated to be 0.92–1.33 for RSV-A and 1.04–1.76 for RSV-B, which varied between different times (2014 and 2015) and places. Conclusions Young infants are likely to acquire RSV infection from older children in the same household. Therefore, vaccination targeting older children might protect infants from RSV infection.
Indonesian Hajj Cohorts and Mortality in Saudi Arabia from 2004 to 2011. International-journal Peer-reviewed

Masdalina Pane, Fiona Yin Mei Kong, Tri Bayu Purnama, Kathryn Glass, Sholah Imari, Gina Samaan, Hitoshi Oshitani

Journal of epidemiology and global health　9　(1)　11-18　2019/03

DOI： 10.2991/jegh.k.181231.001 　

ISSN： 2210-6006

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The Hajj is an annual pilgrimage that 1-2 million Muslims undertake in the Kingdom of Saudi Arabia (KSA), which is the largest mass gathering event in the world, as the world's most populous Muslim nation, Indonesia holds the largest visa quota for the Hajj. All Hajj pilgrims under the quota system are registered in the Indonesian government's Hajj surveillance database to ensure adherence to the KSA authorities' health requirements. Performance of the Hajj and its rites are physically demanding, which may present health risks. This report provides a descriptive overview of mortality in Indonesian pilgrims from 2004 to 2011. The mortality rate from 2004 to 2011 ranged from 149 to 337 per 100,000 Hajj pilgrims, equivalent to the actual number of deaths ranging between 501 and 531 cases. The top two mortality causes were attributable to diseases of the circulatory and respiratory systems. Older pilgrims or pilgrims with comorbidities should be encouraged to take a less physically demanding route in the Hajj. All pilgrims should be educated on health risks and seek early health advice from the mobile medical teams provided.
Distribution of norovirus and sapovirus genotypes with emergence of NoV GII.P16/GII.2 recombinant strains in Chiang Mai, Thailand. International-journal Peer-reviewed

Kanittapon Supadej, Pattara Khamrin, Kattareeya Kumthip, Rungnapa Malasao, Natthawan Chaimongkol, Mayuko Saito, Hitoshi Oshitani, Hiroshi Ushijima, Niwat Maneekarn

Journal of medical virology　91　(2)　215-224　2019/02

DOI： 10.1002/jmv.25261 　

ISSN： 0146-6615
Detection of Subgenotype IA and IIIA Hepatitis A Viruses in Rivers Flowing through Metro Manila, the Philippines. Peer-reviewed

Huimin Bai, Tomoyuki Shiota, Sayaka Yoshizaki, Mariko Saito-Obata, Fedelino F Malbas Jr, Socorro P Lupisan, Hitoshi Oshitani, Naokazu Takeda, Masamichi Muramatsu, Takaji Wakita, Koji Ishii, Tian-Cheng Li

Japanese journal of infectious diseases　72　(1)　53-55　2019/01/23

DOI： 10.7883/yoken.JJID.2018.148 　

ISSN： 1344-6304

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Hepatitis A virus (HAV) is a common infectious etiology of acute hepatitis worldwide. The Philippines remains highly endemic for hepatitis A, but there is still a lack of information about HAV in the country. To evaluate the HAV contamination in environmental water in the Philippines, we conducted the detection and genetic analyses of HAV RNA in samples from river water. Twelve water samples were collected at 6 sampling sites of 3 rivers in Metro Manila, in both the dry and wet seasons in 2012 and 2013. The HAV RNA was detected in all the 6 samples collected in the dry season, and in one sample from the wet season. Phylogenetic analysis confirmed that the HAV strains detected in the river water included multiple sequences belonging to subgenotypes IA and IIIA. This indicates that at least 2 genotypes of the HAV strains are circulating in the environment in the Philippines, posing a risk of HAV infection to not only residents, but also tourists, especially in the dry season.
Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines. International-journal Peer-reviewed

Yuki Furuse, Raita Tamaki, Michiko Okamoto, Mariko Saito-Obata, Akira Suzuki, Mayuko Saito, Tadatsugu Imamura, Irona Khandaker, Isolde Dapat, Fumihiko Ueno, Portia Parian Alday, Alvin Gue Tan, Marianette Tawat Inobaya, Edelwisa Segubre-Mercado, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani

The Journal of infectious diseases　219　(2)　197-205　2019/01/07

DOI： 10.1093/infdis/jiy515 　

ISSN： 0022-1899

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Background: Acute respiratory infection (ARI) is of great concern in public health. It remains unclear whether viral infections can affect the host's susceptibility to subsequent ARIs. Methods: A prospective cohort study on ARIs of children below 5 years old was conducted in the Philippines from 2014 to 2016. The respiratory symptoms were recorded daily, and nasopharyngeal swabs were collected at both household and health facilities. The specimens were tested for respiratory viruses. We then determined whether viral etiology was associated with the severity of the present ARI and whether previous viral infections was associated with subsequent ARIs. Results: A total of 3851 children and 16337 ARI episodes were enrolled and recorded, respectively. Samples were collected from 24% of all ARI episodes; collection rate at the healthcare facilities was 95%. Enterovirus D68, rhinovirus species C, and respiratory syncytial virus were significantly associated with severe ARIs. The risk for subsequent ARIs was significantly enhanced after infections with adenovirus, influenza A virus, parainfluenza virus type 4, and rhinovirus species C. Conclusions: This study revealed that viral etiology plays a significant role in the severity of the present ARI and that viral infection affects the host's susceptibility to subsequent ARIs.
Use of antibiotics for common illnesses among children aged under 5 years in a rural community in Indonesia: a cross-sectional study. Peer-reviewed

Raihana Nadra Alkaff, Taro Kamigaki, Mayuko Saito, Fajar Ariyanti, Dewi Utami Iriani, Hitoshi Oshitani

Tropical medicine and health　47　45-45　2019

DOI： 10.1186/s41182-019-0173-6 　

ISSN： 1348-8945

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Background: The incidence of antimicrobial resistance has been increasing worldwide in the past decades, which includes resistance to bacteria that cause common childhood illnesses, such as acute respiratory infections and diarrhea. Numerous children with those common illnesses are treated with antibiotics. However, in such cases, antibiotic treatment is not required. Community-based studies focusing on antibiotic use among children are still limited. This study aimed to identify the prevalence of antibiotic use for common childhood illnesses and to investigate factors associated with antibiotic use in children under 5 years old as well as female caregivers in a rural community in Indonesia. Methods: A cross-sectional study of 334 children in three villages of Banten Province, located in the western part of Java Island, was conducted in May 2018. Female caregivers who were responsible for providing medications to children were interviewed. We obtained information such as demographic data, any common clinical illness within the last 30 days, and antibiotic usage during an episode of illness. We excluded children with underlying disease that require a regular follow-up and children who were hospitalized in the last 30 days in the analysis. Antibiotic use answered by female caregivers was verified by checking its package or showing photos of various antibiotics to the female caregivers. Crushed antibiotics were confirmed with health professionals. Results: A total of 203 children had clinical symptoms, and the most common symptom was fever and respiratory symptoms. In total, 49.3% received antibiotics, and 66% of them were prescribed by private health professionals. Only two children received antibiotics without a prescription. The most common antibiotic used among children was amoxicillin. Conclusions: The high prevalence of antibiotic use was observed in children under 5 years of age, and the major source to obtain antibiotics was to consult health professionals. Training on appropriate antibiotic use must be conducted for health professionals in not only public but also private sectors.
Complete Genome Sequences of 12 Human Respiratory Syncytial Virus (Human Orthopneumovirus) Strains Detected in Children with Repeated Subgroup B Infections in the Philippines. International-journal Peer-reviewed

Michiko Okamoto, Masahiro Sakamoto, Clyde Dapat, Mayuko Saito, Mariko Saito-Obata, Raita Tamaki, Socorro P Lupisan, Hitoshi Oshitani

Microbiology resource announcements　7　(22)　2018/12

DOI： 10.1128/MRA.01017-18 　

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Complete genome sequences were determined for 12 human respiratory syncytial virus strains collected from nasopharyngeal samples obtained from children with repeated subgroup B infections. Eight common amino acid polymorphisms in the G, F, and L proteins were identified between the viruses detected in initial and subsequent infections.
Etiology and epidemiology of community-acquired pneumonia in adults requiring hospital admission: a prospective study in rural Central Philippines. International-journal Peer-reviewed

Lupisan S, Suzuki A, Macalalad N, Egos R, Sombrero L, Okamoto M, Dapat C, Mondoy M, Galang H, Zeta VFF, de la Pena F, Romano V, Olveda R, Oshitani H

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases　80　46-53　2018/12

DOI： 10.1016/j.ijid.2018.12.005 　

ISSN： 1201-9712

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BACKGROUND: Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality among adults worldwide. However, the distribution of the etiology of CAP varies from one country to another, with limited data from rural areas. METHODS: A prospective hospital-based study on adult CAP was conducted in Leyte, Central Philippines from May 2010 to May 2012. Blood, sputum, and nasopharyngeal samples obtained from patients were used to identify pathogens using standard microbiological culture methods and PCR. RESULTS: Of the 535 patients enrolled, 38% were younger than 50 years old. More than half of the patients had an underlying disease, including pulmonary tuberculosis (22%). The detection rate was higher for bacteria (40%) than viruses (13%). Haemophilus influenzae (12%) was the most commonly detected bacterium and influenza virus (5%) was the most commonly detected virus. The proportion of CAP patients with Mycobacterium tuberculosis infection was higher in the younger age group than in the older age group. Among CAP patients, 14% died during hospitalization, and drowsiness on admission and SpO2 <90% were independent risk factors for mortality. CONCLUSIONS: Bacterial infections contribute substantially to the number of hospitalizations among CAP patients in rural Philippines. This study also highlights the importance of treatment of tuberculosis in reducing the burden of adult CAP in the country.
Father's roles and perspectives on healthcare seeking for children with pneumonia: findings of a qualitative study in a rural community of the Philippines. Peer-reviewed

Sato M, Oshitani H, Tamaki R, Oyamada N, Sato K, Nadra AR, Landicho J, Alday PP, Lupisan S, Tallo VL

BMJ open　8　(11)　e023857-e023857　2018/11
Publisher: BMJ
DOI： 10.1136/bmjopen-2018-023857 　

ISSN： 2044-6055

eISSN： 2044-6055

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Objectives Pneumonia remains a primary cause of death for under-five children. It is possible to reduce the mortality impact from childhood pneumonia if caregivers recognise the danger signs of pneumonia and obtain appropriate healthcare. Among caregivers, research on fathers’ healthcare-seeking behaviours and perceptions are limited, whereas research on mothers is available. This study aims to reveal fathers’ roles and perspectives with respect to the selection of care and treatment for children with pneumonia in a remote island of the Philippines. Design A qualitative research was carried out using semistructured interviews. Setting and participants The interviews were conducted with 12 fathers whose children had pneumonia-like episodes in the 6 months prior to the interview. Data analysis was performed using the concept analysis method to identify codes which were merged into subcategories and categories. Finally, the themes were identified. Results Three themes were identified as part of fathers’ roles, and two were identified as fathers’ perspectives on various treatment options. Fathers took care of their sick children by not entrusting care only to mothers because they considered this as part of their role. Notably, fathers considered that arranging money for the child’s treatment was a matter of prime importance. They selected a particular treatment based on their experiences and beliefs, including herbal medicine, home treatment, and visiting traditional healers and health facilities. Their decision was influenced by not only their perception of the severity of illness but also cultural beliefs on the cause of illness. Visiting health facilities, particularly during hospital admissions, causes significant financial burden for the family which was the main concern of fathers. Conclusion It is crucial to consider the cultural background and also imperative to address issues related to medical cost and the credibility of health facilities to improve fathers’ healthcare-seeking behaviour.
Molecular Characterization of Respiratory Syncytial Virus in Children With Repeated Infections With Subgroup B in the Philippines. International-journal Peer-reviewed

Michiko Okamoto, Clyde P Dapat, Ann Marie D Sandagon, Leilanie P Batangan-Nacion, Irene C Lirio, Raita Tamaki, Mayuko Saito, Mariko Saito-Obata, Socorro P Lupisan, Hitoshi Oshitani

The Journal of infectious diseases　218　(7)　1045-1053　2018/08/24

DOI： 10.1093/infdis/jiy256 　

ISSN： 0022-1899
Comprehensive etiological and epidemiological study on acute respiratory infections in children: Providing evidence for the prevention and control of childhood plneumonia in the Philippines

Raita Tamaki, Raita Tamaki, Veronica L. Tallo, Alvin G. Tan, Mark Donal, C. Reñosa, Portia P. Alday, Jhoys M. Landicho, Marianette T. Inobaya, Mayuko Saito, Taro Kamigaki, Michiko Okamoto, Mariko Saito, Clyde Dapat, Bindongo, P.P. Dembele, Mary Lorraine, S. Mationg, Melisa U. Mondoy, Socorro P. Lupisan, Hitoshi Oshitani

Journal of Disaster Research　13　(4)　740-750　2018/08/01
Publisher: Fuji Technology Press Ltd.
DOI： 10.20965/jdr.2018.p0740 　

ISSN： 1881-2473

eISSN： 1883-8030
Epidemiology of Sapovirus Infections in a Birth Cohort in Peru. International-journal

Gerardo J Sánchez, Holger Mayta, Monica J Pajuelo, Karen Neira, Liu Xiaofang, Lilia Cabrera, Sarah Blythe Ballard, Jean E Crabtree, Dermot Kelleher, Vitaliano Cama, Caryn Bern, Hitoshi Oshitani, Robert H Gilman, Mayuko Saito

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America　66　(12)　1858-1863　2018/06/01

DOI： 10.1093/cid/cix1103 　

ISSN： 1058-4838
Concurrent Community Transmission of Enterovirus D68 With Human Rhinoviruses and Respiratory Syncytial Virus Among Children in Sendai, Japan. Peer-reviewed

Metoki T, Okamoto M, Suzuki A, Kitaoka S, Miyabayashi H, Rokugo Y, Onuma R, Noguchi R, Sato T, Watanabe Y, Ohmiya S, Sato K, Nishimura H, Oshitani H, Kumaki S

The Pediatric infectious disease journal　37　(5)　394-400　2018/05

DOI： 10.1097/INF.0000000000001768 　

ISSN： 0891-3668
Complete Genome Sequences of 13 Human Respiratory Syncytial Virus Subgroup A Strains of Genotypes NA1 and ON1 Isolated in the Philippines. International-journal Peer-reviewed

Rungnapa Malasao, Yuki Furuse, Michiko Okamoto, Clyde Dapat, Mayuko Saito, Mariko Saito-Obata, Raita Tamaki, Edelwisa Segubre-Mercado, Socorro Lupisan, Hitoshi Oshitani

Genome announcements　6　(10)　2018/03/08

DOI： 10.1128/genomeA.00151-18 　
フィリピンの小児呼吸器疾患症例におけるエンテロウイルスD68の疫学的・臨床的解析 Peer-reviewed

齊藤麻理子[小畑], 岡本道子, 齊藤繭子, Chaimongkol Natthawan, 玉記雷太, Lupisan Socorro, 押谷仁

グローバルヘルス合同大会プログラム・抄録集　2017　314-314　2017/11
Publisher: グローバルヘルス合同大会事務局
Complete Coding Genome Sequences of Uncommon GII.8 Sapovirus Strains Identified in Diarrhea Samples Collected from Peruvian Children. International-journal

Emmanuel Kagning Tsinda, Rungnapa Malasao, Yuki Furuse, Robert H Gilman, Xiaofang Liu, Sonia Apaza, Susan Espetia, Vitaliano Cama, Hitoshi Oshitani, Mayuko Saito

Genome announcements　5　(43)　2017/10/26

DOI： 10.1128/genomeA.01137-17 　
Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series Peer-reviewed

Nienke M. Scheltema, Angela Gentile, Florencia Lucion, D. James Nokes, Patrick K. Munywoki, Shabir A. Madhi, Michelle J. Groome, Cheryl Cohen, Jocelyn Moyes, Kentigern Thorburn, Somsak Thamthitiwat, Hitoshi Oshitani, Socorro P. Lupisan, Aubree Gordon, Jose F. Sanchez, Katherine L. O'Brien, Bradford D. Gessner, Agustinus Sutanto, Asuncion Mejias, Octavio Ramilo, Najwa Khuri-Bulos, Natasha Halasa, Fernanda de-Paris, Marcia Rosane Pires, Michael C. Spaeder, Bosco A. Paes, Eric A. F. Simoes, Ting F. Leung, Maria Tereza da Costa Oliveira, Carla Cecilia de Freitas Lazaro Emediato, Quique Bassat, Warwick Butt, Hsin Chi, Uzma Bashir Aamir, Asad Ali, Marilla G. Lucero, Rodrigo A. Fasce, Olga Lopez, Barbara A. Rath, Fernando P. Polack, Jesse Papenburg, Srdan Roglic, Hisato Ito, Edward A. Goka, Diederick E. Grobbee, Harish Nair, Louis J. Bont

LANCET GLOBAL HEALTH　5　(10)　E984-E991　2017/10

DOI： 10.1016/S2214-109X(17)30344-3 　

ISSN： 2214-109X
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Ting Shi, David A. McAllister, Katherine L. O'Brien, Eric A. F. Simoes, Shabir A. Madhi, Bradford D. Gessner, Fernando P. Polack, Evelyn Balsells, Sozinho Acacio, Claudia Aguayo, Issifou Alassani, Asad Ali, Martin Antonio, Shally Awasthi, Juliet O. Awori, Eduardo Azziz-Baumgartner, Henry C. Baggett, Vicky L. Baillie, Angel Balmaseda, Alfredo Barahona, Sudha Basnet, Quique Bassat, Wilma Basualdo, Godfrey Bigogo, Louis Bont, Robert F. Breiman, W. Abdullah Brooks, Shobha Broor, Nigel Bruce, Dana Bruden, Philippe Buchy, Stuart Campbell, Phyllis Carosone-Link, Mandeep Chadha, James Chipeta, Monidarin Chou, Wilfrido Clara, Cheryl Cohen, Elizabeth de Cuellar, Duc-Anh Dang, Budragchaagiin Dash-yandag, Maria Deloria-Knoll, Mukesh Dherani, Tekchheng Eap, Bernard E. Ebruke, Marcela Echavarria, Carla Cecilia de Freitas Lazaro Emediato, Rodrigo A. Fasce, Daniel R. Feikin, Luzhao Feng, Angela Gentile, Aubree Gordon, Doli Goswami, Sophie Goyet, Michelle Groome, Natasha Halasa, Siddhivinayak Hirve, Nusrat Homaira, Stephen R. C. Howie, Jorge Jara, Imane Jroundi, Cissy B. Kartasasmita, Najwa Khuri-Bulos, Karen L. Kotloff, Anand Krishnan, Romina Libster, Olga Lopez, Marilla G. Lucero, Florencia Lucion, Socorro P. Lupisan, Debora N. Marcone, John P. McCracken, Mario Mejia, Jennifer C. Moisi, Joel M. Montgomery, David P. Moore, Cinta Moraleda, Jocelyn Moyes, Patrick Munywoki, Kuswandewi Mutyara, Mark P. Nicol, D. James Nokes, Pagbajabyn Nymadawa, Maria Tereza da Costa Oliveira, Hitoshi Oshitani, Nitin Pandey, Glaucia Paranhos-Baccala, Lia N. Phillips, Valentina Sanchez Picot, Mustafizur Rahman, Mala Rakoto-Andrianarivelo, Zeba A. Rasmussen, Barbara A. Rath, Annick Robinson, Candice Romero, Graciela Russomando, Vahid Salimi, Pongpun Sawatwong, Nienke Scheltema, Brunhilde Schweiger, J. Anthony G. Scott, Phil Seidenberg, Kunling Shen, Rosalyn Singleton, Viviana Sotomayor, Tor A. Strand, Agustinus Sutanto, Mariam Sylla, Milagritos D. Tapia, Somsak Thamthitiwat, Elizabeth D. Thomas, Rafal Tokarz, Claudia Turner, Marietjie Venter, Sunthareeya Waicharoen, Jianwei Wang, Wanitda Watthanaworawit, Lay-Myint Yoshida, Hongjie Yu, Heather J. Zar, Harry Campbell, Harish Nair

LANCET　390　(10098)　946-958　2017/09

DOI： 10.1016/S0140-6736(17)30938-8 　

ISSN： 0140-6736

eISSN： 1474-547X
Analysis of patient data from laboratories during the Ebola virus disease outbreak in Liberia, April 2014 to March 2015 Peer-reviewed

Yuki Furuse, Mosoka Fallah, Hitoshi Oshitani, Ling Kituyi, Nuha Mahmoud, Emmanuel Musa, Alex Gasasira, Tolbert Nyenswah, Bernice Dahn, Luke Bawo

PLOS NEGLECTED TROPICAL DISEASES　11　(7)　2017/07

DOI： 10.1371/journal.pntd.0005804 　

ISSN： 1935-2735
Estimates of influenza and respiratory syncytial virus incidences with fraction modeling approach in Baguio City, the Philippines, 2012-2014 Peer-reviewed

Taro Kamigaki, Portia P. Aldey, Edelwisa S. Mercado, Alvin G. Tan, Jenaline B. Javier, Socorro P. Lupisan, Hitoshi Oshitani, Veronica L. Tallo

INFLUENZA AND OTHER RESPIRATORY VIRUSES　11　(4)　311-318　2017/07

DOI： 10.1111/irv.12453 　

ISSN： 1750-2640

eISSN： 1750-2659
First detection of DS-1-like G1P[8] human rotavirus strains from children with diarrhoea in the Philippines

D. Yamamoto, A. Tandoc, E. Mercado, F. Quicho, S. Lupisan, M. Obata-Saito, M. Okamoto, A. Suzuki, R. Tamaki, L. Sombrero, R. Olveda, H. Oshitani

New Microbes and New Infections　18　54-57　2017/07/01
Publisher: Elsevier Ltd
DOI： 10.1016/j.nmni.2017.04.001 　

ISSN： 2052-2975
Analysis of patient data from laboratories during the Ebola virus disease outbreak in Liberia, April 2014 to March 2015. International-journal

Yuki Furuse, Mosoka Fallah, Hitoshi Oshitani, Ling Kituyi, Nuha Mahmoud, Emmanuel Musa, Alex Gasasira, Tolbert Nyenswah, Bernice Dahn, Luke Bawo

PLoS neglected tropical diseases　11　(7)　e0005804　2017/07

DOI： 10.1371/journal.pntd.0005804 　

ISSN： 1935-2727
Environmental Surveillance of Norovirus Genogroups I and II for Sensitive Detection of Epidemic Variants

Shinobu Kazama, Takayuki Miura, Yoshifumi Masago, Yoshimitsu Konta, Kentaro Tohma, Takafumi Manaka, Xiaofang Liu, Daisuke Nakayama, Takashi Tanno, Mayuko Saito, Hitoshi Oshitani, Tatsuo Omura

APPLIED AND ENVIRONMENTAL MICROBIOLOGY　83　(9)　2017/05

DOI： 10.1128/AEM.03406-16 　

ISSN： 0099-2240

eISSN： 1098-5336
Global Transmission Dynamics of Measles in the Measles Elimination Era. International-journal

Yuki Furuse, Hitoshi Oshitani

Viruses　9　(4)　2017/04/16

DOI： 10.3390/v9040082 　
Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: A systematic review and meta-analysis

Louise E. Lansbury, Sherie Smith, Walter Beyer, Emina Karamehic, Eva Pasic-Juhas, Hana Sikira, Ana Mateus, Hitoshi Oshitani, Hongxin Zhao, Charles R. Beck, Jonathan S. Nguyen-Van-Tam

VACCINE　35　(16)　1996-2006　2017/04

DOI： 10.1016/j.vaccine.2017.02.059 　

ISSN： 0264-410X

eISSN： 1873-2518
Bordetella pertussis infection in children with severe pneumonia, Philippines, 2012-2015

Alexander Sadiasa, Mariko Saito-Obata, Clyde Dapat

VACCINE　35　(7)　993-996　2017/02

DOI： 10.1016/j.vaccine.2016.11.087 　

ISSN： 0264-410X

eISSN： 1873-2518
Applicability of norovirus monitoring in sewage as an early warning system of infectious gastroenteritis Peer-reviewed

Miura, T, Kazama, S, Konta, Y, Masago, Y, Tohma, K, Manaka, T, Liu, X, Saito, M, Oshitani, H, Omura, T

72　(7)　III_285-III_294　2016/12

DOI： 10.2208/jscejer.72.III_285 　
Seasonality of Influenza and Respiratory Syncytial Viruses and the Effect of Climate Factors in Subtropical-Tropical Asia Using Influenza-Like Illness Surveillance Data, 2010-2012

Taro Kamigaki, Liling Chaw, Alvin G. Tan, Raita Tamaki, Portia P. Alday, Jenaline B. Javier, Remigio M. Olveda, Hitoshi Oshitani, Veronica L. Tallo

PLOS ONE　11　(12)　2016/12

DOI： 10.1371/journal.pone.0167712 　

ISSN： 1932-6203
Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses. International-journal

Yuki Furuse, Yoko Matsuzaki, Hidekazu Nishimura, Hitoshi Oshitani

Viruses　8　(12)　2016/11/26

DOI： 10.3390/v8120321 　

eISSN： 1999-4915
Mechanisms of replacement of circulating viruses by seasonal and pandemic influenza A viruses. International-journal

Yuki Furuse, Hitoshi Oshitani

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases　51　6-14　2016/10

DOI： 10.1016/j.ijid.2016.08.012 　

ISSN： 1201-9712
Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014. International-journal

Yoko Matsuzaki, Kanetsu Sugawara, Yuki Furuse, Yoshitaka Shimotai, Seiji Hongo, Hitoshi Oshitani, Katsumi Mizuta, Hidekazu Nishimura

Journal of virology　90　(18)　8251-65　2016/09/15

DOI： 10.1128/JVI.00969-16 　

ISSN： 0022-538X
Comparative Evaluation of Real-Time PCR Methods for Human Noroviruses in Wastewater and Human Stool Peer-reviewed

Yoshifumi Masago, Yoshimitsu Konta, Shinobu Kazama, Manami Inaba, Toshifumi Imagawa, Kentaro Tohma, Mayuko Saito, Akira Suzuki, Hitoshi Oshitani, Tatsuo Omura

PLOS ONE　11　(8)　e0160825　2016/08

DOI： 10.1371/journal.pone.0160825 　

ISSN： 1932-6203
Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines. International-journal

Francois Marie Ngako Kadji, Michiko Okamoto, Yuki Furuse, Raita Tamaki, Akira Suzuki, Irene Lirio, Clyde Dapat, Rungnapa Malasao, Mariko Saito, Gay Anne Granada Pedrera-Rico, Veronica Tallo, Socorro Lupisan, Mayuko Saito, Hitoshi Oshitani

Virology journal　13　113-113　2016/06/27

DOI： 10.1186/s12985-016-0565-8 　
Etiological Role and Repeated Infections of Sapovirus among Children Aged Less than 2 Years in a Cohort Study in a Peri-urban Community of Peru

Xiaofang Liu, Helena Jahuira, Robert H. Gilman, Alicia Alva, Lilia Cabrera, Michiko Okamoto, Hang Xu, Henry J. Windle, Dermot Kelleher, Marco Varela, Manuela Verastegui, Maritza Calderon, Gerardo Sanchez, Vanessa Sarabia, Sarah B. Ballard, Caryn Bern, Holger Mayta, Jean E. Crabtree, Vitaliano Cama, Mayuko Saito, Hitoshi Oshitani

JOURNAL OF CLINICAL MICROBIOLOGY　54　(6)　1598-1604　2016/06

DOI： 10.1128/JCM.03133-15 　

ISSN： 0095-1137

eISSN： 1098-660X
Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam

Keisuke Yoshihara, Minh Nhat Le, Michiko Okamoto, Anita Carolle Akpeedje Wadagni, Hien Anh Nguyen, Michiko Toizumi, Enga Pham, Motoi Suzuki, Ai Thi Thuy Nguyen, Hitoshi Oshitani, Koya Ariyoshi, Hiroyuki Moriuchi, Masahiro Hashizume, Duc Anh Dang, Lay-Myint Yoshida

SCIENTIFIC REPORTS　6　2016/06

DOI： 10.1038/srep27856 　

ISSN： 2045-2322
Local persistence and global dissemination play a significant role in the circulation of influenza B viruses in Leyte Island, Philippines. International-journal

Yuki Furuse, Takashi Odagiri, Raita Tamaki, Taro Kamigaki, Hirono Otomaru, Jamie Opinion, Arlene Santo, Donna Dolina-Lacaba, Edgard Daya, Michiko Okamoto, Mariko Saito-Obata, Marianette Inobaya, Alvin Tan, Veronica Tallo, Socorro Lupisan, Akira Suzuki, Hitoshi Oshitani

Virology　492　21-4　2016/05

DOI： 10.1016/j.virol.2016.02.001 　

ISSN： 0042-6822
Highly Efficient CRISPR/Cas9-Mediated Cloning and Functional Characterization of Gastric Cancer-Derived Epstein-Barr Virus Strains. International-journal

Teru Kanda, Yuki Furuse, Hitoshi Oshitani, Tohru Kiyono

Journal of virology　90　(9)　4383-93　2016/05

DOI： 10.1128/JVI.00060-16 　

ISSN： 0022-538X
Molecular Characterization of Chikungunya Virus, Philippines, 2011-2013

Ava Kristy Sy, Mariko Saito-Obata, Inez Andrea Medado, Kentaro Tohma, Clyde Dapat, Edelwisa Segubre-Mercado, Amado Tandoc, Socorro Lupisan, Hitoshi Oshitani

EMERGING INFECTIOUS DISEASES　22　(5)　887-890　2016/05

DOI： 10.3201/eid2205.151268 　

ISSN： 1080-6040

eISSN： 1080-6059
Temporal dynamics of norovirus determined through monitoring of municipal wastewater by pyrosequencing and virological surveillance of gastroenteritis cases

Shinobu Kazama, Yoshifumi Masago, Kentaro Tohma, Nao Souma, Toshifumi Imagawa, Akira Suzuki, Xiaofang Liu, Mayuko Saito, Hitoshi Oshitani, Tatsuo Omura

WATER RESEARCH　92　244-253　2016/04

DOI： 10.1016/j.watres.2015.10.024 　

ISSN： 0043-1354

eISSN： 1879-2448
Molecular and mathematical modeling analyses of inter-island transmission of rabies into a previously rabies-free island in the Philippines

Kentaro Tohma, Mariko Saito, Catalino S. Demetria, Daria L. Manalo, Beatriz P. Quiambao, Taro Kamigaki, Hitoshi Oshitani

INFECTION GENETICS AND EVOLUTION　38　22-28　2016/03

DOI： 10.1016/j.meegid.2015.12.001 　

ISSN： 1567-1348

eISSN： 1567-7257
Novel insights into human respiratory syncytial virus-host factor interactions through integrated proteomics and transcriptomics analysis

Clyde Dapat, Hitoshi Oshitani

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY　14　(3)　285-297　2016/03

DOI： 10.1586/14787210.2016.1141676 　

ISSN： 1478-7210

eISSN： 1744-8336
Burden of Influenza and Respiratory Syncytial Virus Infection in Pregnant Women and Infants Under 6 Months in Mongolia: A Prospective Cohort Study

Liling Chaw, Taro Kamigaki, Alexanderyn Burmaa, Chuluunbatiin Urtnasan, Ishiin Od, Gunregjaviin Nyamaa, Pagbajabyn Nymadawa, Hitoshi Oshitani

PLOS ONE　11　(2)　2016/02

DOI： 10.1371/journal.pone.0148421 　

ISSN： 1932-6203
Immediate Needs and Concerns among Pregnant Women During and after Typhoon Haiyan (Yolanda). International-journal

Mari Sato, Yasuka Nakamura, Fumi Atogami, Ribeka Horiguchi, Raita Tamaki, Toyoko Yoshizawa, Hitoshi Oshitani

PLoS currents　8　2016/01/25

DOI： 10.1371/currents.dis.29e4c0c810db47d7fd8d0d1fb782892c 　
Laboratory diagnosis for outbreak-prone infectious diseases after typhoon Yolanda (Haiyan), Philippines

Mariko Saito-Obata, Mayuko Saito, Titus C. Tan, Inez Andrea P. Medado, Clyde Dapat, Michiko Okamoto, Raita Tamaki, Rowena C. Capistrano, Edelwisa Segubre-Mercado, Socorro P. Lupisan, Hitoshi Oshitani

PLoS Currents　8　2016
Publisher: Public Library of Science
DOI： 10.1371/currents.dis.9c3cb7b01ec2d04eef2406dbe03d253d 　

ISSN： 2157-3999
Trends in avian influenza

Yuki Furuse, Hitoshi Oshitani

Japanese Journal of Chest Diseases　74　1352-1357　2015/12/01

ISSN： 0385-3667
Conservation of nucleotide sequences for molecular diagnosis of Middle East respiratory syndrome coronavirus, 2015. International-journal

Yuki Furuse, Michiko Okamoto, Hitoshi Oshitani

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases　40　25-7　2015/11

DOI： 10.1016/j.ijid.2015.09.018 　

ISSN： 1201-9712
Molecular Characterization of Human Respiratory Syncytial Virus in the Philippines, 2012-2013

Rungnapa Malasao, Michiko Okamoto, Natthawan Chaimongkol, Tadatsugu Imamura, Kentaro Tohma, Isolde Dapat, Clyde Dapat, Akira Suzuki, Mayuko Saito, Mariko Saito, Raita Tamaki, Gay Anne Granada Pedrera-Rico, Rapunzel Aniceto, Reynaldo Frederick Negosa Quicho, Edelwisa Segubre-Mercado, Socorro Lupisan, Hitoshi Oshitani

PLOS ONE　10　(11)　2015/11

DOI： 10.1371/journal.pone.0142192 　

ISSN： 1932-6203
Molecular detection and characterization of sapovirus in hospitalized children with acute gastroenteritis in the Philippines Peer-reviewed

Xiaofang Liu, Dai Yamamoto, Mariko Saito, Toshifumi Imagawa, Adrianne Ablola, Amado O. Tandoc, Edelwisa Segubre-Mercado, Socorro P. Lupisan, Michiko Okamoto, Yuki Furuse, Mayuko Saito, Hitoshi Oshitani

JOURNAL OF CLINICAL VIROLOGY　68　83-88　2015/07

DOI： 10.1016/j.jcv.2015.05.001 　

ISSN： 1386-6532

eISSN： 1873-5967
Molecular Epidemiology of the Human Rhinovirus Infection in Mongolia during 2008-2013 Peer-reviewed

Sosorbaram Tsatsral, Zichun Xiang, Naoko Fuji, Chulunbatar Maitsetseg, Janchiv Khulan, Hitoshi Oshitani, Jianwei Wang, Pagbajabyn Nymadawa

JAPANESE JOURNAL OF INFECTIOUS DISEASES　68　(4)　280-287　2015/07

DOI： 10.7883/yoken.JJID.2014.090 　

ISSN： 1344-6304

eISSN： 1884-2836
Seroprevalence of chronic hepatitis B, as determined from dried blood spots, among children and their mothers in central Lao People's Democratic Republic: a multistage, stratified cluster sampling survey

Kenichi Komada, Masaya Sugiyama, Phengta Vongphrachanh, Anonh Xeuatvongsa, Bouaphan Khamphaphongphane, Tomomi Kitamura, Tomoko Kiyohara, Takaji Wakita, Hitoshi Oshitani, Masahiko Hachiya

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　36　21-26　2015/07

DOI： 10.1016/j.ijid.2015.04.020 　

ISSN： 1201-9712

eISSN： 1878-3511
Analysis of influenza transmission in the households of primary and junior high school students during the 2012-13 influenza season in Odate, Japan

Taro Kamigaki, Satoshi Mimura, Yoshihiro Takahashi, Hitoshi Oshitani

BMC INFECTIOUS DISEASES　15　2015/07

DOI： 10.1186/s12879-015-1007-8 　

ISSN： 1471-2334
Genetic characterization of measles virus in the Philippines, 2008-2011. International-journal

Rex Centeno, Naoko Fuji, Michiko Okamoto, Clyde Dapat, Mariko Saito, Amado Tandoc, Socorro Lupisan, Hitoshi Oshitani

BMC research notes　8　211-211　2015/06/03

DOI： 10.1186/s13104-015-1201-1 　
Intersubtype Genetic Variation of HIV-1 Tat Exon 1

Chandra Nath Roy, Irona Khandaker, Hitoshi Oshitani

AIDS RESEARCH AND HUMAN RETROVIRUSES　31　(6)　641-648　2015/06

DOI： 10.1089/aid.2014.0346 　

ISSN： 0889-2229

eISSN： 1931-8405
Molecular epidemiology of Bordetella pertussis in the Philippines in 2012-2014

Salvacion Rosario L. Galit, Nao Otsuka, Yuki Furuse, Daryl Joy V. Almonia, Lydia T. Sombrero, Rosario Z. Capeding, Socorro P. Lupisan, Mariko Saito, Hitoshi Oshitani, Yukihiro Hiramatsu, Keigo Shibayama, Kazunari Kamachi

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　35　24-26　2015/06

DOI： 10.1016/j.ijid.2015.04.001 　

ISSN： 1201-9712

eISSN： 1878-3511
Evolutionary Dynamics of Tat in HIV-1 Subtypes B and C

Chandra Nath Roy, Irona Khandaker, Hitoshi Oshitani

PLOS ONE　10　(6)　2015/06

DOI： 10.1371/journal.pone.0129896 　

ISSN： 1932-6203
Incidence and Risk Factors of Childhood Pneumonia-Like Episodes in Biliran Island, Philippines-A Community-Based Study

Hisato Kosai, Raita Tamaki, Mayuko Saito, Kentaro Tohma, Portia Parian Alday, Alvin Gue Tan, Marianette Tawat Inobaya, Akira Suzuki, Taro Kamigaki, Soccoro Lupisan, Veronica Tallo, Hitoshi Oshitani

PLOS ONE　10　(5)　2015/05

DOI： 10.1371/journal.pone.0125009 　

ISSN： 1932-6203
Role of Preschool and Primary School Children in Epidemics of Influenza A in a Local Community in Japan during Two Consecutive Seasons with A(H3N2) as a Predominant Subtype

Satoshi Mimura, Taro Kamigaki, Yoshihiro Takahashi, Takamichi Umenai, Mataka Kudou, Hitoshi Oshitani

PLOS ONE　10　(5)　2015/05

DOI： 10.1371/journal.pone.0125642 　

ISSN： 1932-6203
Influenza and Other Respiratory Viruses Detected by Influenza-Like Illness Surveillance in Leyte Island, the Philippines, 2010-2013

Hirono Otomaru, Taro Kamigaki, Raita Tamaki, Jamie Opinion, Arlene Santo, Edgard Daya, Michiko Okamoto, Mariko Saito, Veronica Tallo, Soccoro Lupisan, Akira Suzuki, Hitoshi Oshitani

PLOS ONE　10　(4)　2015/04

DOI： 10.1371/journal.pone.0123755 　

ISSN： 1932-6203
Molecular characterization of full-length Tat in HIV-1 subtypes B and C. International-journal Peer-reviewed

Roy CN, Khandaker I, Furuse Y, Oshitani H

Bioinformation　11　(3)　151-160　2015/03

DOI： 10.6026/97320630011151 　

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HIV-1Tat (trans-acting activator of transcription) plays essential roles in the replication through viral mRNA and genome transcription from the HIV-1 LTR promoter. However, Tat undergoes continuous amino acid substitutions. As a consequence, the virus escapes from host immunity indicating that genetic diversity of Tat protein in major HIV-1 subtypes is required to be continuously monitored. We analyzed available full-length HIV-1 sequences of subtypes B (n=493) and C (n=280) strains circulating worldwide. We observed 81% and 84% nucleotide sequence identities of HIV-1 Tat for subtypes B and C, respectively. Based on phylogenetic and mutation analyses, global diversity of subtype B was apparently higher compared to that of subtype C. Positively selected sites, such as positions Ser68 and Ser70 in both subtypes, were located in the Tat-transactivation responsive RNA (TAR) interaction domain. We also found positively selected sites in exon 2, such as positions Ser75, Pro77, Asp80, Pro81 and Ser87 for both subtypes. Our study provides useful information on the full-length HIV-1 Tat sequences in globally circulating strains.
Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections Peer-reviewed

Tadatsugu Imamura, Hitoshi Oshitani

REVIEWS IN MEDICAL VIROLOGY　25　(2)　102-114　2015/03

DOI： 10.1002/rmv.1820 　

ISSN： 1052-9276

eISSN： 1099-1654
Isolation and Characterization of Influenza C Viruses in the Philippines and Japan

Takashi Odagiri, Yoko Matsuzaki, Michiko Okamoto, Akira Suzuki, Mariko Saito, Raita Tamaki, Socorro P. Lupisan, Lydia T. Sombrero, Seiji Hongo, Hitoshi Oshitani

JOURNAL OF CLINICAL MICROBIOLOGY　53　(3)　847-858　2015/03

DOI： 10.1128/JCM.02628-14 　

ISSN： 0095-1137

eISSN： 1098-660X
Molecular Epidemiology of Enterovirus D68 from 2013 to 2014 in Philippines

Yuki Furuse, Natthawan Chaimongkol, Michiko Okamoto, Tadatsugu Imamura, Mariko Saito, Raita Tamaki, Mayuko Saito, Socorro P. Lupisan, Hitoshi Oshitani

JOURNAL OF CLINICAL MICROBIOLOGY　53　(3)　1015-1018　2015/03

DOI： 10.1128/JCM.03362-14 　

ISSN： 0095-1137

eISSN： 1098-660X
Human G3P[4] rotavirus obtained in Japan, 2013, possibly emerged through a human-equine rotavirus reassortment event Peer-reviewed

Rungnapa Malasao, Mayuko Saito, Akira Suzuki, Toshifumi Imagawa, Nao Nukiwa-Soma, Kentaro Tohma, Xiaofang Liu, Michiko Okamoto, Natthawan Chaimongkol, Clyde Dapat, Kazuhisa Kawamura, Yasuko Kayama, Yoshifumi Masago, Tatsuo Omura, Hitoshi Oshitani

VIRUS GENES　50　(1)　129-133　2015/02

DOI： 10.1007/s11262-014-1135-z 　

ISSN： 0920-8569

eISSN： 1572-994X
Socio-demographic characteristics and geographic distribution of reported malaria cases in Bangka district, Babel island province, Indonesia during 2008-2012

Shodiana, Taro Kamigaki, Hitoshi Oshitani

Southeast Asian Journal of Tropical Medicine and Public Health　46　(6)　965-976　2015
Publisher: SEAMEO TROPMED Network
ISSN： 0125-1562
Seroprevalence and molecular characteristics of hepatitis E virus in household-raised pig population in the Philippines

Xiaofang Liu, Mariko Saito, Yusuke Sayama, Ellie Suzuki, Fedelino F. Malbas, Hazel O. Galang, Yuki Furuse, Mayuko Saito, Tiancheng Li, Akira Suzuki, Hitoshi Oshitani

BMC VETERINARY RESEARCH　11　2015/01

DOI： 10.1186/s12917-015-0322-z 　

ISSN： 1746-6148
Characteristics of a Plasma-induced Flow using a Mesh Electrode for Viral Inactivation

Yuji Kudo, Michiko Okamoto, Takehiko Sato, Daisuke Yoshino, Akira Suzuki, Hitoshi Oshitani

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI2014)　106-107　2014/10/09
Epidemiology and impact of influenza in Mongolia, 2007-2012 Peer-reviewed

Alexanderyn Burmaa, Taro Kamigaki, Badarchyn Darmaa, Pagbajabyn Nymadawa, Hitoshi Oshitani

INFLUENZA AND OTHER RESPIRATORY VIRUSES　8　(5)　530-537　2014/09

DOI： 10.1111/irv.12268 　

ISSN： 1750-2640

eISSN： 1750-2659
Analysis of medical consultation interval between the symptom onset and consultation observed in multiple medical facilities in Odate city, Japan, 2011/2012 and 2012/2013 seasons Peer-reviewed

Xiang Huo, Taro Kamigaki, Satoshi Mimura, Yoshihiro Takahashi, Hitoshi Oshitani

JOURNAL OF INFECTION AND CHEMOTHERAPY　20　(5-6)　370-374　2014/05

DOI： 10.1016/j.jiac.2014.02.005 　

ISSN： 1341-321X

eISSN： 1437-7780
School closures during the 2009 influenza pandemic: national and local experiences Peer-reviewed

Simon Cauchemez, Maria D. Van Kerkhove, Brett N. Archer, Martin Cetron, Benjamin J. Cowling, Peter Grove, Darren Hunt, Mira Kojouharova, Predrag Kon, Kumnuan Ungchusak, Hitoshi Oshitani, Andrea Pugliese, Caterina Rizzo, Guillaume Saour, Tomimase Sunagawa, Amra Uzicanin, Claude Wachtel, Isaac Weisfuse, Hongjie Yu, Angus Nicoll

BMC INFECTIOUS DISEASES　14　207-207　2014/04

DOI： 10.1186/1471-2334-14-207 　

ISSN： 1471-2334
Short Report: Molecular Detection of Hepatitis E Virus in Rivers in the Philippines Peer-reviewed

Tian-Cheng Li, Tingting Yang, Tomoyuki Shiota, Sayaka Yoshizaki, Hiromu Yoshida, Mariko Saito, Toshifumi Imagawa, Fidelino F. Malbas, Socorro P. Lupisan, Hitoshi Oshitani, Takaji Wakita, Koji Ishii

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE　90　(4)　764-766　2014/04

DOI： 10.4269/ajtmh.13-0562 　

ISSN： 0002-9637

eISSN： 1476-1645
Phylogeographic analysis of rabies viruses in the Philippines Peer-reviewed

Kentaro Tohma, Mariko Saito, Taro Kamigaki, Laarni T. Tuason, Catalino S. Demetria, Jun Ryan C. Orbina, Dania L. Manalo, Mary E. Miranda, Akira Noguchi, Satoshi Inoue, Akira Suzuki, Beatriz P. Quiambao, Hitoshi Oshitani

INFECTION GENETICS AND EVOLUTION　23　86-94　2014/04

DOI： 10.1016/j.meegid.2014.01.026 　

ISSN： 1567-1348

eISSN： 1567-7257
Impact of Human Adenovirus Serotype 7 in Hospitalized Children with Severe Fatal Pneumonia in the Philippines Peer-reviewed

Dai Yamamoto, Michiko Okamoto, Socorro Lupisan, Akira Suzuki, Mariko Saito, Raita Tamaki, Amado Tandoc, Edelwisa Mercado, Lydia Sombrero, Remigio Olveda, Hitoshi Oshitani

JAPANESE JOURNAL OF INFECTIOUS DISEASES　67　(2)　105-110　2014/03

DOI： 10.7883/yoken.67.105 　

ISSN： 1344-6304

eISSN： 1884-2836
Estimating influenza outpatients' and inpatients' incidences from 2009 to 2011 in a tropical urban setting in the Philippines Peer-reviewed

Veronica L. Tallo, Taro Kamigaki, Alvin G. Tan, Rochelle R. Pamaran, Portia P. Alday, Edelwisa S. Mercado, Jenaline B. Javier, Hitoshi Oshitani, Remigio M. Olveda

INFLUENZA AND OTHER RESPIRATORY VIRUSES　8　(2)　159-168　2014/03

DOI： 10.1111/irv.12223 　

ISSN： 1750-2640

eISSN： 1750-2659
Antigenic and Receptor Binding Properties of Enterovirus 68 Peer-reviewed

Tadatsugu Imamura, Michiko Okamoto, Shin-ichi Nakakita, Akira Suzuki, Mariko Saito, Raita Tamaki, Socorro Lupisan, Chandra Nath Roy, Hiroaki Hiramatsu, Kan-etsu Sugawara, Katsumi Mizuta, Yoko Matsuzaki, Yasuo Suzuki, Hitoshi Oshitani

JOURNAL OF VIROLOGY　88　(5)　2374-2384　2014/03

DOI： 10.1128/JVI.03070-13 　

ISSN： 0022-538X

eISSN： 1098-5514
Investigation of an Influenza A (H3N2) outbreak in evacuation centres following the Great East Japan earthquake, 2011 Peer-reviewed

Taro Kamigaki, Jin Seino, Kentaro Tohma, Nao Nukiwa-Soma, Kanako Otani, Hitoshi Oshitani

BMC PUBLIC HEALTH　14　34-34　2014/01

DOI： 10.1186/1471-2458-14-34 　

ISSN： 1471-2458
[Oseltamivir resistance among pandemic A(H1N1)2009 viruses between 2009 and 2011 in Guangzhou]. Peer-reviewed

Guan, Wenda Tsui, Stephen K W Lee, Simon M Y Yang, Zifeng Luo, Yi Li, Xiaobo Wu, Shiguan Wang, Yutao Oshitani, Hitoshi Suzuki, Akira Chen, Rongchang Zhong, Nanshan

Zhonghua Jie He He Hu Xi Za Zhi　37　(1)　16-20　2014/01
Detection of enterovirus 68 in serum from pediatric patients with pneumonia and their clinical outcomes Peer-reviewed

Tadatsugu Imamura, Akira Suzuki, Socorro Lupisan, Taro Kamigaki, Michiko Okamoto, Chandra Nath Roy, Remigio Olveda, Hitoshi Oshitani

INFLUENZA AND OTHER RESPIRATORY VIRUSES　8　(1)　21-24　2014/01

DOI： 10.1111/irv.12206 　

ISSN： 1750-2640

eISSN： 1750-2659
Molecular evolution of the hemagglutinin and neuraminidase genes of pandemic (H1N1) 2009 influenza viruses in Sendai, Japan, during 2009-2011 Peer-reviewed

Irona Khandaker, Akira Suzuki, Taro Kamigaki, Kentaro Tohma, Takashi Odagiri, Takashi Okada, Ayumu Ohno, Kanako Otani, Rumi Sawayama, Kazuhisa Kawamura, Michiko Okamoto, Hitoshi Oshitani

VIRUS GENES　47　(3)　456-466　2013/12

DOI： 10.1007/s11262-013-0980-5 　

ISSN： 0920-8569

eISSN： 1572-994X
Characteristics of Non-equilibrium Plasma Flow for Viral Inactivation

Yuji Kudo, Michiko Okamoto, Daisuke Yoshino, Takehiko Sato, Akira Suzuki, Hitoshi Oshitani

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI 2013)　66-67　2013/11/26
Epidemiological Characterization of Influenza A(H1N1)pdm09 Cases from 2009 to 2010 in Baguio City, the Philippines Peer-reviewed

Rochelle R. Pamaran, Taro Kamigaki, Teresita T. Hewe, Korrine Madeleine C. Flores, Edelwisa S. Mercado, Portia P. Alday, Alvin G. Tan, Hitoshi Oshitani, Remigio M. Olveda, Veronica L. Tallo

PLOS ONE　8　(11)　e79916-e79916　2013/11

DOI： 10.1371/journal.pone.0079916 　

ISSN： 1932-6203
[Infectious disease surveillance in Miyagi after the Great East Japan Earthquake]. Peer-reviewed

Kim, Mihyun Kamigaki, Taro Mimura, Satoshi Oshitani, Hitoshi

Nihon Koshu Eisei Zasshi　60　(10)　659-664　2013/10
Publisher:
DOI： 10.11236/jph.60.10_659 　

ISSN： 0546-1766
Molecular Evolution of Enterovirus 68 Detected in the Philippines Peer-reviewed

Tadatsugu Imamura, Akira Suzuki, Socorro Lupisan, Michiko Okamoto, Rapunzel Aniceto, Rutchie J. Egos, Edgardo E. Daya, Raita Tamaki, Mariko Saito, Naoko Fuji, Chandra Nath Roy, Jaime M. Opinion, Arlene V. Santo, Noel G. Macalalad, Amado Tandoc, Lydia Sombrero, Remigio Olveda, Hitoshi Oshitani

PLOS ONE　8　(9)　e74221-e74221　2013/09

DOI： 10.1371/journal.pone.0074221 　

ISSN： 1932-6203
Hemagglutination mediated by the spike protein of cell-adapted bovine torovirus Peer-reviewed

Kozue Shimabukuro, Makoto Ujike, Toshihiro Ito, Hiroshi Tsunemitsu, Hitoshi Oshitani, Fumihiro Taguchi

ARCHIVES OF VIROLOGY　158　(7)　1561-1566　2013/07

DOI： 10.1007/s00705-013-1636-4 　

ISSN： 0304-8608
Prospects for emerging infections in East and Southeast Asia 10 years after severe acute respiratory syndrome Peer-reviewed

Peter W. Horby, Dirk Pfeiffer, Hitoshi Oshitani

Emerging Infectious Diseases　19　(6)　853-860　2013/06

DOI： 10.3201/eid1906.121783 　

ISSN： 1080-6040 1080-6059
東北大学大学院医学系研究科による東日本大震災被災者支援の試み地域保健支援センターの活動

中原篤史, 柿崎真沙子, 佐藤眞理, 佐藤紀子, 平野かよ子, 押谷仁, 辻一郎

公衆衛生　77　(5)　416-420　2013/05/15
Publisher: 医学書院
DOI： 10.11477/mf.1401102743 　

ISSN： 1882-1170 0368-5187
Genetic characterization of human respiratory syncytial virus detected in hospitalized children in the Philippines from 2008 to 2012 Peer-reviewed

Ayumu Ohno, Akira Suzuki, Socorro Lupisan, Hazel Galang, Lydia Sombrero, Rapunzel Aniceto, Michiko Okamoto, Mariko Saito, Naoko Fuji, Hirono Otomaru, Chandra Nath Roy, Dai Yamamoto, Raita Tamaki, Remigio Olveda, Hitoshi Oshitani

JOURNAL OF CLINICAL VIROLOGY　57　(1)　59-65　2013/05

DOI： 10.1016/j.jcv.2013.01.001 　

ISSN： 1386-6532
A case report of a patient in whom antibodies against the 2009 pandemic influenza A/H1N1 virus have been present since June 1999 Peer-reviewed

Masashi Yoshida, Hirotoshi Sugino, Tadashi Iizuka, Liu Xiaofang, Akira Suzuki, Hitoshi Oshitani, Tatsuo Suzutani, Kazufumi Ikuta

HUMAN VACCINES & IMMUNOTHERAPEUTICS　9　(5)　989-992　2013/05

DOI： 10.4161/hv.23427 　

ISSN： 2164-5515

eISSN： 2164-554X
ラオス人民民主共和国中部における乾燥ろ紙血を用いたHBs抗原調査多段階層化収束抽出法による小児及び母親の陽性率推定(Seroprevalence of chronic hepatitis B among children and their mothers in central Lao People's Democratic Republic: A multistage stratified cluster sampling survey using dried blood spots)

Vongphrachanh Phengta, Xeuatvongsa Anonh, 押谷仁, 蜂矢正彦, 駒田謙一, 木多村知美, 清原知子, 脇田隆字, 杉山真也, 溝上雅史

感染症学雑誌　87　(1)　156-157　2013/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
ラオス人民民主共和国全国における迅速キットを用いたHBs抗原調査多段階層化収束抽出法による小児及び母親の陽性率推定(Seroprevalence of chronic hepatitis B among children and their mothers in Lao People's Democratic Republic: A nationwide multistage stratified cluster sampling survey using rapid field tests)

Xeuatvongsa Anonh, Vongphrachanh Phengta, 押谷仁, 蜂矢正彦, 駒田謙一, 木多村知美, 杉山真也, 溝上雅史, 石井孝司, 脇田隆字

感染症学雑誌　87　(1)　157-157　2013/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
Genetic diversity and geographic distribution of genetically distinct rabies viruses in the Philippines. International-journal Peer-reviewed

Mariko Saito, Hitoshi Oshitani, Jun Ryan C Orbina, Kentaro Tohma, Alice S de Guzman, Taro Kamigaki, Catalino S Demetria, Daria L Manalo, Mary Elizabeth G Miranda, Akira Noguchi, Satoshi Inoue, Beatriz P Quiambao

PLoS neglected tropical diseases　7　(4)　e2144-e2144　2013

DOI： 10.1371/journal.pntd.0002144 　

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BACKGROUND: Rabies continues to be a major public health problem in the Philippines, where 200-300 human cases were reported annually between 2001 and 2011. Understanding the phylogeography of rabies viruses is important for establishing a more effective and feasible control strategy. METHODS: We performed a molecular analysis of rabies viruses in the Philippines using rabied animal brain samples. The samples were collected from 11 of 17 regions, which covered three island groups (Luzon, Visayas, and Mindanao). Partial nucleoprotein (N) gene sequencing was performed on 57 samples and complete glycoprotein (G) gene sequencing was performed on 235 samples collected between 2004 and 2010. RESULTS: The Philippine strains of rabies viruses were included in a distinct phylogenetic cluster, previously named Asian 2b, which appeared to have diverged from the Chinese strain named Asian 2a. The Philippine strains were further divided into three major clades, which were found exclusively in different island groups: clades L, V, and M in Luzon, Visayas, and Mindanao, respectively. Clade L was subdivided into nine subclades (L1-L9) and clade V was subdivided into two subclades (V1 and V2). With a few exceptions, most strains in each subclade were distributed in specific geographic areas. There were also four strains that were divided into two genogroups but were not classified into any of the three major clades, and all four strains were found in the island group of Luzon. CONCLUSION: We detected three major clades and two distinct genogroups of rabies viruses in the Philippines. Our data suggest that viruses of each clade and subclade evolved independently in each area without frequent introduction into other areas. An important implication of these data is that geographically targeted dog vaccination using the island group approach may effectively control rabies in the Philippines.
[Researches on virology at the Tohoku University Research Center in the Philippines]. Peer-reviewed

Hitoshi Oshitani, Mariko Saito, Michiko Okamoto, Raita Tamaki, Taro Kamigaki, Akira Suzuki

Uirusu　63　(1)　45-50　2013

ISSN： 0042-6857

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Tohoku University Graduate School of Medicine has established the Tohoku-RITM Collaborative Research Center on Emerging and Re-emerging Diseases at Research Institute for Tropical Medicine (RITM) in the Philippines in 2008. Our aim of the center is to conduct operational researches, which can contribute to control of infectious diseases in the Philippines. Therefore most of our researches in the Philippines are being conducted in the fields. Main research themes include severe acute respiratory infections in children, influenza disease burden study, molecular epidemiology of rabies, and viral etiology of acute diarrhea. The study on severe acute respiratory infections in children in Leyte Island has recruited hospitalized cases with severe pneumonia. We showed that enterovirus 68 was one of important causative agents in severe pneumonia cases. We also conducted other analyses including molecular epidemiology of respiratory syncytial virus (RSV) and pathogenesis of human rhinoviruses (HRV). Based on these studies, we initiated more comprehensive researches in the Philippines since 2010.
Impact of the Tohoku earthquake and tsunami on pneumonia hospitalisations and mortality among adults in northern Miyagi, Japan: A multicentre observational study Peer-reviewed

Hisayoshi Daito, Motoi Suzuki, Jun Shiihara, Paul E. Kilgore, Hitoshi Ohtomo, Konosuke Morimoto, Masayuki Ishida, Taro Kamigaki, Hitoshi Oshitani, Masahiro Hashizume, Wataru Endo, Koichi Hagiwara, Koya Ariyoshi, Shoji Okinaga

Thorax　68　(6)　544-550　2013
Publisher: BMJ Publishing Group
DOI： 10.1136/thoraxjnl-2012-202658 　

ISSN： 1468-3296 0040-6376
Monitoring of Influenza Viruses in the Aftermath of the Great East Japan Earthquake Peer-reviewed

Kentaro Tohma, Akira Suzuki, Kanako Otani, Michiko Okamoto, Nao Nukiwa, Taro Kamigaki, Kazuhisa Kawamura, Hiroshi Nakagawa, Hitoshi Oshitani

JAPANESE JOURNAL OF INFECTIOUS DISEASES　65　(6)　542-544　2012/11

DOI： 10.7883/yoken.65.542 　

ISSN： 1344-6304

eISSN： 1884-2836
Cumulative incidence of pandemic influenza A (H1N1) 2009 by a community-based serological cohort study in Selenghe Province, Mongolia Peer-reviewed

Alexanderyn Burmaa, Sosorbaramyn Tsatsral, Takashi Odagiri, Akira Suzuki, Hitoshi Oshitani, Pagbajabyn Nymadawa

INFLUENZA AND OTHER RESPIRATORY VIRUSES　6　(6)　e97-e104　2012/11

DOI： 10.1111/j.1750-2659.2012.00334.x 　

ISSN： 1750-2640
Respiratory viruses from hospitalized children with severe pneumonia in the Philippines Peer-reviewed

Akira Suzuki, Socorro Lupisan, Yuki Furuse, Naoko Fuji, Mariko Saito, Raita Tamaki, Hazel Galang, Lydia Sombrero, Melisa Mondoy, Rapunzel Aniceto, Remigio Olveda, Hitoshi Oshitani

BMC INFECTIOUS DISEASES　12　267-267　2012/10

DOI： 10.1186/1471-2334-12-267 　

ISSN： 1471-2334
Genetic diversity and molecular characterization of enteroviruses from sewage-polluted urban and rural rivers in the Philippines Peer-reviewed

Lea Necitas G. Apostol, Tomifumi Imagawa, Akira Suzuki, Yoshifumi Masago, Socorro Lupisan, Remigio Olveda, Mariko Saito, Tatsuo Omura, Hitoshi Oshitani

VIRUS GENES　45　(2)　207-217　2012/10

DOI： 10.1007/s11262-012-0776-z 　

ISSN： 0920-8569

eISSN： 1572-994X
Detection and Serotyping of Human Adenoviruses from Patients with Influenza-Like Illness in Mongolia Peer-reviewed

Kentaro Tohma, Namuuntsetsegiin Bayasgalan, Akira Suzuki, Badarchiin Darma, Hitoshi Oshitani, Pagbajabyn Nymadawa

JAPANESE JOURNAL OF INFECTIOUS DISEASES　65　(4)　289-294　2012/07

DOI： 10.7883/yoken.65.289 　

ISSN： 1344-6304

eISSN： 1884-2836
A seroepidemiologic study of Reston ebolavirus in swine in the Philippines Peer-reviewed

Yusuke Sayama, Catalino Demetria, Mariko Saito, Rachel R. Azul, Satoshi Taniguchi, Shuetsu Fukushi, Tomoki Yoshikawa, Itoe Iizuka, Tetsuya Mizutani, Ichiro Kurane, Fidelino F. Malbas, Socorro Lupisan, Davinio P. Catbagan, Samuel B. Animas, Rieldrin G. Morales, Emelinda L. Lopez, Karen Rose C. Dazo, Magdalena S. Cruz, Remigio Olveda, Masayuki Saijo, Hitoshi Oshitani, Shigeru Morikawa

BMC VETERINARY RESEARCH　8　82-82　2012/06

DOI： 10.1186/1746-6148-8-82 　

ISSN： 1746-6148
Enhancing the response outcome of infectious disease treatment following natural disasters

Isidore K. Kouadio, Syed Mohamed Aljunid

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY　10　(5)　531-532　2012/05

DOI： 10.1586/ERI.12.40 　

ISSN： 1478-7210
Detection of non-polio enteroviruses from 17 years of virological surveillance of acute flaccid paralysis in the Philippines Peer-reviewed

Lea Necitas Apostol, Akira Suzuki, Analisa Bautista, Hazel Galang, Fem Julia Paladin, Naoko Fuji, Socorro Lupisan, Remigio Olveda, Hitoshi Oshitani

JOURNAL OF MEDICAL VIROLOGY　84　(4)　624-631　2012/04

DOI： 10.1002/jmv.23242 　

ISSN： 0146-6615
Influenza Transmission in a Community during a Seasonal Influenza A(H3N2) Outbreak (2010-2011) in Mongolia: A Community-Based Prospective Cohort Study Peer-reviewed

Nao Nukiwa-Souma, Alexanderyn Burmaa, Taro Kamigaki, Ishiin Od, Namuutsetsegiin Bayasgalan, Badarchiin Darmaa, Akira Suzuki, Pagbajabyn Nymadawa, Hitoshi Oshitani

PLOS ONE　7　(3)　e33046-e33046　2012/03

DOI： 10.1371/journal.pone.0033046 　

ISSN： 1932-6203
Risk Factors of Household Transmission of Pandemic (H1N1) 2009 among Patients Treated with Antivirals: A Prospective Study at a Primary Clinic in Japan Peer-reviewed

Nobuo Hirotsu, Koji Wada, Hitoshi Oshitani

PLOS ONE　7　(2)　e31519-e31519　2012/02

DOI： 10.1371/journal.pone.0031519 　

ISSN： 1932-6203
Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010 Peer-reviewed

Tatsuya Ikeda, Katsumi Mizuta, Chieko Abiko, Yoko Aoki, Tsutomu Itagaki, Fumio Katsushima, Yuriko Katsushima, Yoko Matsuzaki, Naoko Fuji, Tadatsugu Imamura, Hitoshi Oshitani, Masahiro Noda, Hirokazu Kimura, Tadayuki Ahiko

MICROBIOLOGY AND IMMUNOLOGY　56　(2)　139-143　2012/02

DOI： 10.1111/j.1348-0421.2012.00411.x 　

ISSN： 0385-5600
Infectious diseases following natural disasters: prevention and control measures Peer-reviewed

Isidore K. Kouadio, Syed Aljunid, Taro Kamigaki, Karen Hammad, Hitoshi Oshitani

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY　10　(1)　95-104　2012/01

DOI： 10.1586/ERI.11.155 　

ISSN： 1478-7210
マニラ首都圏における台風Ketsanaによる洪水域内環境水からの病原性レプトスピラの検出 Peer-reviewed

沼澤聡, 真砂佳史, 齊藤麻理子, 山口諒, 押谷仁, 大村達夫

土木学会論文集G（環境）　67　(7)　III_165-III_171　2011/11
Detection of Human Rhinovirus C Viral Genome in Blood among Children with Severe Respiratory Infections in the Philippines Peer-reviewed

Naoko Fuji, Akira Suzuki, Socorro Lupisan, Lydia Sombrero, Hazel Galang, Taro Kamigaki, Raita Tamaki, Mariko Saito, Rapunzel Aniceto, Remigio Olveda, Hitoshi Oshitani

PLOS ONE　6　(11)　e27247-e27247　2011/11

DOI： 10.1371/journal.pone.0027247 　

ISSN： 1932-6203
Mucosal immunity against influenza induced by attenuated recombinant Sendai virus Peer-reviewed

Tadatsugu Imamura, Hitoshi Oshitani

EXPERT REVIEW OF VACCINES　10　(10)　1393-1395　2011/10

DOI： 10.1586/ERV.11.123 　

ISSN： 1476-0584
Enterovirus 68 among Children with Severe Acute Respiratory Infection, the Philippines Peer-reviewed

Tadatsugu Imamura, Naoko Fuji, Akira Suzuki, Raita Tamaki, Mariko Saito, Rapunzel Aniceto, Hazel Galang, Lydia Sombrero, Soccoro Lupisan, Hitoshi Oshitani

EMERGING INFECTIOUS DISEASES　17　(8)　1430-1435　2011/08

DOI： 10.3201/eid1708.101328 　

ISSN： 1080-6040
Interruption of the Circulation of an Indigenous Measles Genotype and the Introduction of Other Genotypes After a Mass Vaccination Campaign in the Philippines Peer-reviewed

Naoko Fuji, Akira Suzuki, Mariko Saito, Rex Centeno, Hazel Galang, Socorro Lupisan, Remigio Olveda, Hitoshi Oshitani

JOURNAL OF MEDICAL VIROLOGY　83　(8)　1424-1427　2011/08

DOI： 10.1002/jmv.22103 　

ISSN： 0146-6615
Evolution of the influenza A virus untranslated regions Peer-reviewed

Yuki Furuse, Hitoshi Oshitani

INFECTION GENETICS AND EVOLUTION　11　(5)　1150-1154　2011/07

DOI： 10.1016/j.meegid.2011.04.006 　

ISSN： 1567-1348
Effects of Vaccination against Pandemic (H1N1) 2009 among Japanese Children Peer-reviewed

Hiroshi Nishiura, Hitoshi Oshitani

EMERGING INFECTIOUS DISEASES　17　(4)　746-747　2011/04

DOI： 10.3201/eid1704.100525 　

ISSN： 1080-6040
Household Transmission of Influenza (H1N1-2009) in Japan: Age-specificity and Reduction of Household Transmission Risk by Zanamivir Treatment Peer-reviewed

H. Nishiura, H. Oshitani

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH　39　(2)　619-628　2011/03

ISSN： 0300-0605
2008/09シーズンのインフルエンザ流行期における外来受診行動に関する調査研究

神垣太郎, 橋本亜希子, 貫和奈央, 玉記雷太, 押谷仁

感染症学雑誌　85　(1)　128-129　2011/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Prevalence of Phasi Charoen Virus in Female Mosquitoes

Yusuke Sayama, Yuki Eshita, Takuya Yamao, Miho Nishimura, Tomomitsu Satho, Raweewan Srisawat, Narumon Komalamisra, Yupha Rongsriyam, Kouji Sakai, Shuetsu Fukushi, Masayuki Saijo, Hitoshi Oshitani, Ichiro Kurane, Shigeru Morikawa, Tetsuya Mizutani

J. Parasitology and Vector Biology　3　(1)　19-21　2011/01
Viruses That Cross Borders: Factors Responsible for Global Dissemination of Viral Infections Peer-reviewed

Yuki Furuse, Akira Suzuki, Taro Kamigaki, Emmanuel Abraham Mpolya, Irona Khandaker, Hitoshi Oshitani

INTERVIROLOGY　54　(5)　246-252　2011

DOI： 10.1159/000320967 　

ISSN： 0300-5526
Evaluating influenza disease burden during the 2008-2009 and 2009-2010 influenza seasons in Mongolia. Peer-reviewed

Nukiwa, Nao Burmaa, Alexanderyn Kamigaki, Taro Darmaa, Badarchiin Od, Jigjidsurengiin Od, Ishiin Gantsooj, Baataryn Naranzul, Tsedenbalyn Tsatsral, Sosorbaramyn Enkhbaatar, Luvsanbaldangiin Tuul, Rentsengiin Oshitani, Hitoshi Nymadawa, Pagbajabyn

Western Pac Surveill Response J　2　(1)　16-22　2011/01

DOI： 10.5365/WPSAR.2010.1.1.004 　
Simplified screening method for detecting oseltamivir resistant pandemic influenza A (H1N1) 2009 virus by a RT-PCR/restriction fragment length polymorphism assay Peer-reviewed

Nao Nukiwa, Akira Suzuki, Yuki Furuse, Kozue Shimabukuro, Takashi Odagiri, Irona Khandaker, Hitoshi Oshitani

JOURNAL OF VIROLOGICAL METHODS　170　(1-2)　165-168　2010/12

DOI： 10.1016/j.jviromet.2010.09.005 　

ISSN： 0166-0934
2008〜2009シーズンの庄内地域における季節性インフルエンザ外来患者からみた医療施設への負荷の検討

貫和奈央, 神垣太郎, 河村真人, 橋本亜希子, 玉記雷太, 押谷仁

感染症学雑誌　84　(6)　808-808　2010/11
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
2009/2010シーズンに仙台市内で流行したRSウイルスの解析

大野歩, 鈴木陽, 押谷仁, 川村和久

外来小児科　13　(3)　381-381　2010/11
Publisher: (一社)日本外来小児科学会
ISSN： 1345-8043
【これからのインフルエンザ対策】インフルエンザの社会的対策

神垣太郎, 玉記雷太, 押谷仁

臨床と微生物　37　(増刊)　521-524　2010/10
Publisher: (株)近代出版
ISSN： 0910-7029
Influenza surveillance and control in the Western Pacific Region. Peer-reviewed

Oshitani, Hitoshi

Western Pac Surveill Response J　1　(1)　3-4　2010/10

DOI： 10.5365/WPSAR.2010.1.1.005 　
Fatal Cases of Pandemic (H1N1) 2009 Influenza despite Their Early Antiviral Treatment in Japan Peer-reviewed

Nao Nukiwa, Taro Kamigaki, Hitoshi Oshitani

CLINICAL INFECTIOUS DISEASES　51　(8)　993-994　2010/10

DOI： 10.1086/656443 　

ISSN： 1058-4838
拡大サーベイランスに基づく長野県佐久地域の2008/09シーズンにおけるインフルエンザ様患者数に関する検討

河村真人, 神垣太郎, 貫和奈央, 橋本亜希子, 玉記雷太, 押谷仁

感染症学雑誌　84　(5)　575-582　2010/09
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
[Epidemiological study of influenza-like illness under enhanced surveillance in Saku, Nagano Prefecture, outpatients during the 2008-09 influenza season]. Peer-reviewed

Kawamura, Masato Kamigaki, Taro Nukiwa, Nao Hashimoto, Akiko Tamaki, Raita Oshitani, Hotoshi

Kansenshogaku Zasshi　84　(5)　575-582　2010/09
Publisher: The Japanese Association for Infectious Diseases
DOI： 10.11150/kansenshogakuzasshi.84.575 　

ISSN： 0387-5911

More details Close

Many influenza-like illness (ILI) outpatients visit healthcare facilities such as internal medicine and pediatric clinics every year. In Japan, however, ILI is reported only by sentinel healthcare facilities. We studied the number of ILI subjects visiting sentinel and non-sentinel healthcare facilities during the 2008-09 season in Saku, Nagano prefecture, obtaining the numbers of cases from sentinel and non-sentinel facilities. Most ILI subjects visited internal and pediatric facilities, and some visited otorhinolaryngological clinics not included as sentinel sites. We also estimated the total number of influenza cases based on data from sentinel facilities and total surveyed facilities, including non-sentinel. We divided facilities into hospitals with pediatrics, pediatric clinics, internal medicine and pediatric clinics, hospitals and clinics with internal medicine but no pediatrics, and otorhinolaryngological clinics. Estimated sentinel-site ILI cases was 2,862, including 1,020 for hospitals with pediatrics and 1,674 for clinics with internal medicine and pediatrics. The estimated number of ILI cases from total facilities surveyed was significantly lower, at 503 for hospitals with pediatrics,and 741 for clinics with internal medicine and pediatrics. Estimated ILI cases from categories not including sentinel sites were 967 for hospitals and clinics with internal medicine but no pediatrics, and 71 for otorhinolaryngological clinics. The estimated number of total ILI cases differed by 18.5％, depending on facility categories. This indicates that more detailed analysis is needed to accurately estimate ILI cases.
Differentiation of human influenza A viruses including the pandemic subtype H1N1/2009 by conventional multiplex PCR Peer-reviewed

Yuki Furuse, Takashi Odagiri, Takashi Okada, Irona Khandaker, Kozue Shimabukuro, Rumi Sawayama, Akira Suzuki, Hitoshi Oshitani

JOURNAL OF VIROLOGICAL METHODS　168　(1-2)　94-97　2010/09

DOI： 10.1016/j.jviromet.2010.04.023 　

ISSN： 0166-0934
Comparison of selection pressures on the HA gene of pandemic (2009) and seasonal human and swine influenza A H1 subtype viruses Peer-reviewed

Yuki Furuse, Kozue Shimabukuro, Takashi Odagiri, Rumi Sawayama, Takashi Okada, Irona Khandaker, Akira Suzuki, Hitoshi Oshitani

VIROLOGY　405　(2)　314-321　2010/09

DOI： 10.1016/j.virol.2010.06.018 　

ISSN： 0042-6822
新規呼吸器ウイルス感染症のフィリピンにおける疫学調査

古瀬祐気, 鈴木陽, 押谷仁

感染症学雑誌　84　(4)　539-540　2010/07
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
Detection of Novel Respiratory Viruses From Influenza-Like Illness in the Philippines Peer-reviewed

Yuki Furuse, Akira Suzuki, Makiko Kishi, Hazel O. Galang, Socorro P. Lupisan, Remigio M. Olveda, Hitoshi Oshitani

JOURNAL OF MEDICAL VIROLOGY　82　(6)　1071-1074　2010/06

DOI： 10.1002/jmv.21763 　

ISSN： 0146-6615
Proteomics search of influenza A viruses for adaptive mutations to human hosts Peer-reviewed

Yuki Furuse, Hitoshi Oshitani

EXPERT REVIEW OF PROTEOMICS　7　(3)　323-326　2010/06

DOI： 10.1586/EPR.10.28 　

ISSN： 1478-9450
Reassortment between swine influenza A viruses increased their adaptation to humans in pandemic H1N1/09 Peer-reviewed

Yuki Furuse, Akira Suzuki, Hitoshi Oshitani

INFECTION GENETICS AND EVOLUTION　10　(4)　569-574　2010/05

DOI： 10.1016/j.meegid.2010.01.010 　

ISSN： 1567-1348
2008-2009シーズンの庄内地域における季節性インフルエンザ外来患者からみた医療施設への負荷の検討

貫和奈央, 神垣太郎, 河村真人, 橋本亜希子, 玉記雷太, 押谷仁

感染症学雑誌　84　(臨増)　417-417　2010/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
呼吸器感染症新規呼吸器ウイルス感染症のフィリピンにおける疫学調査

古瀬祐気, 鈴木陽, 押谷仁

感染症学雑誌　84　(臨増)　183-183　2010/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
2008-2009年フィリピン・レイテ島タクロバンにおいて小児重症肺炎患者から検出されたRSウイルス

大野歩, 鈴木陽, 藤直子, 古瀬祐気, 玉記雷太, 齋藤麻理子, 押谷仁

感染症学雑誌　84　(臨増)　290-290　2010/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Measles outbreaks in displaced populations: a review of transmission, morbidity and mortality associated factors Peer-reviewed

Isidore K. Kouadio, Taro Kamigaki, Hitoshi Oshitani

BMC INTERNATIONAL HEALTH AND HUMAN RIGHTS　10　5-5　2010/03

DOI： 10.1186/1472-698X-10-5 　

ISSN： 1472-698X
Origin of measles virus: divergence from rinderpest virus between the 11(th) and 12(th) centuries Peer-reviewed

Yuki Furuse, Akira Suzuki, Hitoshi Oshitani

VIROLOGY JOURNAL　7　52-52　2010/03

DOI： 10.1186/1743-422X-7-52 　

ISSN： 1743-422X
Occurrence of Mixed Populations of Influenza A Viruses That Can Be Maintained through Transmission in a Single Host and Potential for Reassortment Peer-reviewed

Yuki Furuse, Akira Suzuki, Makiko Kishi, Nao Nukiwa, Midori Shimizu, Rumi Sawayama, Naoko Fuji, Hitoshi Oshitani

JOURNAL OF CLINICAL MICROBIOLOGY　48　(2)　369-374　2010/02

DOI： 10.1128/JCM.01795-09 　

ISSN： 0095-1137
Evolutionary analyses on the HA gene ofpandemic H1N1/09: early findings. Peer-reviewed

Furuse, Yuki Suzuki, Akira Oshitani, Hitoshi

Bioinformation　5　(1)　7-10　2010
Influenza pandemic preparedness and severity assessment of pandemic (H1N1) 2009 in South-east Asia Peer-reviewed

T. Kamigaki, H. Oshitani

PUBLIC HEALTH　124　(1)　5-9　2010/01

DOI： 10.1016/j.puhe.2009.11.003 　

ISSN： 0033-3506
フィリピン・レイテ島における小児重症肺炎の疫学調査

鈴木陽, 古瀬祐気, 藤直子, 大野歩, 玉記雷太, 齋藤麻理子, 押谷仁

日本小児科学会雑誌　113　(12)　1876-1876　2009/12
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
Reassortment between Amantadine-Resistant and -Sensitive H1N1 Influenza A Viruses Generated an Amantadine-Sensitive Virus during the 2007-2008 Season Peer-reviewed

Yuki Furuse, Akira Suzuki, Midori Shimizu, Makiko Kishi, Rumi Sawayama, Mariko Saito, Naoko Fuji, Nao Nukiwa, Hitoshi Oshitani

JOURNAL OF INFECTIOUS DISEASES　200　(11)　1766-1773　2009/12

DOI： 10.1086/647989 　

ISSN： 0022-1899
アジアインフルエンザにおける学校閉鎖とMortality impactに関する疫学的検討

神垣太郎, 玉記雷太, 橋本亜希子, 押谷仁

感染症学雑誌　83　(6)　692-692　2009/11
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Lancet conferences: Influenza in the Asia-Pacific Peer-reviewed

Taro Kamigaki, Hitoshi Oshitani

Expert Review of Vaccines　8　(11)　1527-1529　2009/11

DOI： 10.1586/erv.09.119 　

ISSN： 1476-0584 1744-8395
Outbreak of measles and rubella in refugee transit camps Peer-reviewed

I. K. Kouadio, A. K. Koffi, H. Attoh-Toure, T. Kamigaki, H. Oshitani

EPIDEMIOLOGY AND INFECTION　137　(11)　1593-1601　2009/11

DOI： 10.1017/S0950268809002520 　

ISSN： 0950-2688
アジアにおける急性肺炎サーベイランスの感度の検討

橋本亜希子, 神垣太郎, 玉記雷太, 押谷仁

日本公衆衛生学会総会抄録集　68回　300-300　2009/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Large-Scale Sequence Analysis of M Gene of Influenza A Viruses from Different Species: Mechanisms for Emergence and Spread of Amantadine Resistance Peer-reviewed

Yuki Furuse, Akira Suzuki, Hitoshi Oshitani

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY　53　(10)　4457-4463　2009/10

DOI： 10.1128/AAC.00650-09 　

ISSN： 0066-4804
Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis Peer-reviewed

Yuki Furuse, Akira Suzuki, Taro Kamigaki, Hitoshi Oshitani

VIROLOGY JOURNAL　6　67-67　2009/05

DOI： 10.1186/1743-422X-6-67 　

ISSN： 1743-422X
アジアインフルエンザにおける学校閉鎖とMortality impactに関する疫学的検討

神垣太郎, 玉記雷太, 橋本亜希子, 押谷仁

感染症学雑誌　83　(臨増)　298-298　2009/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Reversion of Influenza A (H3N2) Virus from Amantadine Resistant to Amantadine Sensitive by Further Reassortment in Japan during the 2006-to-2007 Influenza Season Peer-reviewed

Yuki Furuse, Akira Suzuki, Taro Kamigaki, Midori Shimizu, Naoko Fuji, Hitoshi Oshitani

JOURNAL OF CLINICAL MICROBIOLOGY　47　(3)　841-844　2009/03

DOI： 10.1128/JCM.01622-08 　

ISSN： 0095-1137
Stability of the seven hexon hypervariable region sequences of adenovirus types 1-6 isolated in Yamagata, Japan between 1988 and 2007 Peer-reviewed

Katsumi Mizuta, Yoko Matsuzaki, Seiji Hongo, Akira Ohmi, Michiko Okamoto, Hidekazu Nishimura, Tsutomu Itagaki, Noriko Katsushima, Hitoshi Oshitani, Akira Suzuki, Yuki Furuse, Masahiro Noda, Hirokazu Kimura, Tadayuki Ahiko

VIRUS RESEARCH　140　(1-2)　32-39　2009/03

DOI： 10.1016/j.virusres.2008.10.014 　

ISSN： 0168-1702
Encephalitis and encephalopathy associated with pandemic flu Peer-reviewed

Raita Tamaki, Taro Kamigaki, Hitoshi Oshitani

Brain and Nerve　61　(2)　153-160　2009/02

ISSN： 1881-6096
The Pandemic (H1N1) 2009 Virus: From an Epidemiologic Triangle Viewpoint. Peer-reviewed

Mpolya EA, Furuse Y, Nukiwa N, Suzuki A, Kamigaki T, Oshitani H

Journal of Disaster Research　4　(5)　356-364　2009
Epidemiological characteristics and low case fatality rate of pandemic (H1N1) 2009 in Japan Peer-reviewed

Taro Kamigaki, Hitoshi Oshitani

PLoS Currents　1　RRN1139-RRN1139　2009

DOI： 10.1371/currents.RRN1139 　

ISSN： 2157-3999
仙台市内で流行したインフルエンザウイルスの薬剤耐性

古瀬祐気, 鈴木陽, 押谷仁, 阿部修一, 板野正敬, 井上重夫, 遠藤晃彦, 加納一毅, 萱場潤, 嘉山益子, 川村和久, 関信夫, 田山利幸, 速水俊三, 松本文子, 目時規公也, 師保之, 八木恒夫, 山本克哉, 吉田眞

日本小児科学会雑誌　112　(9)　1431-1431　2008/09
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
Major issues and challenges of influenza pandemic preparedness in developing countries Peer-reviewed

Hitoshi Oshitani, Taro Kamigaki, Akira Suzuki

EMERGING INFECTIOUS DISEASES　14　(6)　875-880　2008/06

DOI： 10.3201/eid1406.070839 　

ISSN： 1080-6040
Risk factors for human infection with avian influenza A H5N1, Vietnam, 2004 Peer-reviewed

Pham Ngoc Dinh, Hoang Thuy Long, Nguyen Thi Kim Tien, Nguyen Tran Hien, Le Thi Quynh Mai, Le Hong Phong, Le Van Tuan, Hoang Van Tan, Nguyen Binh Nguyen, Phan Van Tu, Nguyen Thi Minh Phuong

EMERGING INFECTIOUS DISEASES　12　(12)　1841-1847　2006/12

DOI： 10.3201/eid1212.060829 　

ISSN： 1080-6040

eISSN： 1080-6059
Potential benefits and limitations of various strategies to mitigate the impact of an influenza pandemic Peer-reviewed

Hitoshi Oshitani

Journal of Infection and Chemotherapy　12　(4)　167-171　2006
Publisher: Springer Japan
DOI： 10.1007/s10156-006-0453-z 　

ISSN： 1341-321X
Implementing the new International Health Regulations in the Pacific--challenges and opportunities. Peer-reviewed

Hitoshi Oshitani, Hitoshi Ailan, Li Roces, Maria Concepcion Sian, Dato' Tee, Ah Ken, Chen Kiedrzynski, Tom

Pac Health Dialog　12　(2)　135-143　2005/09
Lessons learned from international responses to severe acute respiratory syndrome (SARS). Peer-reviewed

Oshitani, Hitoshi

Environ Health Prev Med　10　(5)　251-254　2005/09
Publisher: The Japanese Society for Hygiene
DOI： 10.1007/BF02897698 　

ISSN： 1342-078X

More details Close

In early February 2003, a previously unknown disease causing severe pneumonia was recognised. This disease which is now known as severe acute respiratory syndrome (SARS) is believed to have had its origins in the Guangdong Province of China, and was the cause of a multi-country epidemic resulting in significant morbidity and mortality. The World Health Organization (WHO) has been coordi-nating the international response to provide the epidemiological, laboratory, clinical and logistic requirements needed to contain this disease. A rapid spread of SARS around the world occurred at its onset, facilitated greatly by air travel. Between November 2002 and July 2003, a total of 8,094 cases and 774 cases were reported from 26 countries worldwide. WHO responded quickly to this multi-country outbreak and on 12 March released a "global alert" about SARS. This was followed by the first WHO travel advisory on 15 March. The Global Outbreak Alert and Response Network was activated, and international experts were brought together to implement enhanced global surveillance systems for SARS. The international community has learned a lot of lessons from the SARS outbreak. Particularly, rapid and transparent information sharing between countries is critical to prevent international spread of the disease. However, information exchange was less than optimal in the early phase of the outbreak.
Lessons learned from international responses to severe acute respiratory syndrome (SARS) (Environmental Health and Preventive Medicine)

Oshitani Hitoshi

Environmental Health and Preventive Medicine　10　(5)　251-254　2005/09
Publisher: The Japanese Society for Hygiene
DOI： 10.1265/ehpm.10.251 　

ISSN： 1342-078X

More details Close

In early February 2003, a previously unknown disease causing severe pneumonia was recognised. This disease which is now known as severe acute respiratory syndrome (SARS) is believed to have had its origins in the Guangdong Province of China, and was the cause of a multi-country epidemic resulting in significant morbidity and mortality. The World Health Organization (WHO) has been coordi-nating the international response to provide the epidemiological, laboratory, clinical and logistic requirements needed to contain this disease. A rapid spread of SARS around the world occurred at its onset, facilitated greatly by air travel. Between November 2002 and July 2003, a total of 8,094 cases and 774 cases were reported from 26 countries worldwide. WHO responded quickly to this multi-country outbreak and on 12 March released a "global alert" about SARS. This was followed by the first WHO travel advisory on 15 March. The Global Outbreak Alert and Response Network was activated, and international experts were brought together to implement enhanced global surveillance systems for SARS. The international community has learned a lot of lessons from the SARS outbreak. Particularly, rapid and transparent information sharing between countries is critical to prevent international spread of the disease. However, information exchange was less than optimal in the early phase of the outbreak.
Rumor surveillance and avian influenza H5N1 Peer-reviewed

G Samaan, M Patel, B Olowokure, MC Roces, H Oshitani

EMERGING INFECTIOUS DISEASES　11　(3)　463-466　2005/03

DOI： 10.3201/eid1103.040657 　

ISSN： 1080-6040
Lack of H5N1 Avian influenza transmission to hospital employees, Hanoi, 2004 Peer-reviewed

NT Liem, W Lim

EMERGING INFECTIOUS DISEASES　11　(2)　210-215　2005/02

DOI： 10.3201/eid1102.041075 　

ISSN： 1080-6040
Can oral cholera vaccination play a role in controlling a cholera outbreak? Peer-reviewed

P Calain, JP Chaine, E Johnson, ML Hawley, MJ O'Leary, H Oshitani, CL Chaignat

VACCINE　22　(19)　2444-2451　2004/06

DOI： 10.1016/j.vaccine.2003.11.070 　

ISSN： 0264-410X
Public health interventions and SARS spread, 2003

David M. Bell, David M. Bell, David M. Bell, David M. Bell, David M. Bell, Ximena Aguilera, Roy Anderson, Dounia Bitar, Martin Cetron, Pattie Simone, Chew Suok Kai, Benjamin K.W. Koh, Clete DiGiovanni, Arlene King, Cindy K.L. Lai, P. L. Ma, Angus Nicoll, Jane Leese, Sonja Olsen, Alice Sarradet, Mingchang Song, Ron St. John, Susan Courage, Robert Steffen, Leonie Prasad, Ih Jen Su, S. K. Lai, Julie Hall, Emmanuel Jesuthasan, Angela Merianos, Cathy Roth, Max Hardiman, Hitoshi Oshitani

Emerging Infectious Diseases　10　1900-1906　2004/01/01

DOI： 10.3201/eid1011.040729 　

ISSN： 1080-6040
Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2 Peer-reviewed

R Saito, T Sakai, Sato, I, Y Sano, H Oshitani, M Sato, H Suzuki

JOURNAL OF CLINICAL MICROBIOLOGY　41　(5)　2164-2165　2003/05

DOI： 10.1128/JCM.41.5.2164-2165.2003 　

ISSN： 0095-1137
Emergence of amantadine-resistant influenza A viruses: Epidemiological study Peer-reviewed

Hiroshi Suzuki, Reiko Saito, Hiroki Masuda, Hitoshi Oshitani, Mizuho Sato, Isamu Sato

Journal of Infection and Chemotherapy　9　(3)　195-200　2003
Publisher: Springer Japan
DOI： 10.1007/s10156-003-0262-6 　

ISSN： 1341-321X
The effectiveness of influenza vaccine against influenza A (H3N2) virus infections in nursing homes in Niigata, Japan, during the 1998-1999 and 1999-2000 seasons Peer-reviewed

R Saito, H Suzuki, H Oshitani, T Sakai, N Seki, N Tanabe

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY　23　(2)　82-86　2002/02

DOI： 10.1086/502011 　

ISSN： 0899-823X
Detection of amantadine-resistant influenza A virus strains in nursing homes by PCR-restriction fragment length polymorphism analysis with nasopharyngeal swabs Peer-reviewed

R Saito, H Oshitani, H Masuda, H Suzuki

JOURNAL OF CLINICAL MICROBIOLOGY　40　(1)　84-88　2002/01

DOI： 10.1128/JCM.40.1.84-88.2002 　

ISSN： 0095-1137
Excess amantadine use and resistant viruses Peer-reviewed

H Suzuki, R Saito, H Oshitani

LANCET　358　(9296)　1910-1910　2001/12

DOI： 10.1016/S0140-6736(01)06919-7 　

ISSN： 0140-6736
Influenza vaccination levels and influenza-like illness in long-term-care facilities for elderly people in Niigata, Japan, during an influenza A (H3N2) epidemic Peer-reviewed

H Oshitani, R Saito, N Seki, N Tanabe, O Yamazaki, S Hayashi, H Suzuki

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY　21　(11)　728-730　2000/11

DOI： 10.1086/501725 　

ISSN： 0899-823X
新潟県内高齢者施設におけるA型インフルエンザウイルスのアマンタジン耐性株(Ser-31-Asn遺伝子型,genotype)出現頻度 Peer-reviewed

斎藤玲子, 増田, 寛樹, 押谷, 仁, 鈴木, 宏, 川崎, 聡, 佐藤博

感染症学雑誌　74　(8)　646-652　2000/08
Publisher:
DOI： 10.11150/kansenshogakuzasshi1970.74.646 　

ISSN： 0387-5911
Influenza vaccination in elderly people and its efficacy - Prevention and control of influenza infections in nursing homes

H. Suzuki, R. Saito, H. Oshitani

Japanese Journal of Chest Diseases　59　(9)　662-669　2000

ISSN： 0385-3667
Incidence of amantadine-resistant influenza A viruses in sentinel surveillance sites and nursing homes in Niigata, Japan Peer-reviewed

H Masuda, H Suzuki, H Oshitani, R Saito, S Kawasaki, M Nishikawa, H Satoh

MICROBIOLOGY AND IMMUNOLOGY　44　(10)　833-839　2000

DOI： 10.1111/j.1348-0421.2000.tb02571.x 　

ISSN： 0385-5600
[Antibody induction and frequency of adverse reactions to influenza vaccines in the elderly]. Peer-reviewed

Murayama, N Saito, R Suzuki, H Oshitani, H Kawasaki, S Nishikawa, M Arakawa, M

Kansenshogaku Zasshi　74　(1)　30-36　2000/01
Publisher:
ISSN： 0387-5911
高齢者におけるインフルエンザワクチン接種後の抗体変動と副反応 Peer-reviewed

村山直也, 斎藤, 玲子, 鈴木, 宏, 押谷, 仁, 川崎, 聡, 西川, 眞, 荒川正昭

感染症学雑誌　74　(1)　30-36　2000/01
Publisher:
DOI： 10.11150/kansenshogakuzasshi1970.74.30 　

ISSN： 0387-5911
新潟県内高齢者施設におけるインフルエンザ流行とワクチン効果

斎藤玲子, 押谷仁, 関奈緒, 田辺直仁, 宮西邦夫, 鈴木宏, 村山直也, 川崎聡, 上村桂

日本公衆衛生学会総会抄録集　58回　668-668　1999/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Replication of clinical measles virus strains in hispid cotton rats Peer-reviewed

PR Wyde, DK Moore-Poveda, NJ Daley, H Oshitani

PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE　221　(1)　53-62　1999/05

DOI： 10.1046/j.1525-1373.1999.d01-54.x 　

ISSN： 0037-9727
Effect of prostaglandin A and tunicamycin on rotavirus assembly Peer-reviewed

H Suzuki, H Oshitani

JOURNAL OF INFECTIOUS DISEASES　179　(2)　522-522　1999/02

ISSN： 0022-1899
Effect of prostaglandin A and tunicamycin on rotavirus assembly Peer-reviewed

H Suzuki, H Oshitani

JOURNAL OF INFECTIOUS DISEASES　179　(2)　522-522　1999/02

DOI： 10.1086/314611 　

ISSN： 0022-1899
PCR-RFLP analysis of cytomegalovirus infections associated with bone marrow transplantation in Japanese children Peer-reviewed

S Kawasaki, H Oshitani, H Suzuki, M Arakawa, K Mizuta, M Imaizumi, S Tsuchiya, T Konno

MICROBIOLOGY AND IMMUNOLOGY　43　(4)　359-364　1999

DOI： 10.1111/j.1348-0421.1999.tb02416.x 　

ISSN： 0385-5600
Respiratory syncytial virus infection in children with acute respiratory infections in Zambia Peer-reviewed

M Saijo, H Terunuma, K Mizuta, EM Mpabalwani, M Monze, H Oshitani, N Luo, H Suzuki, Y Numazaki

EPIDEMIOLOGY AND INFECTION　121　(2)　397-400　1998/10

DOI： 10.1017/S0950268898001228 　

ISSN： 0950-2688
Characterization of VP6 subgroup, VP7 and VP4 genotype of rotavirus strains in Lusaka, Zambia Peer-reviewed

AD Steele, FC Kasolo, P Bos, Peenze, I, H Oshitani, E Mpabalwani

ANNALS OF TROPICAL PAEDIATRICS　18　(2)　111-116　1998/06

ISSN： 0272-4936
Isolation of measles virus from infants in Lusaka Peer-reviewed

H Oshitani, ME Mpabalwani, H Suzuki

LANCET　351　(9113)　1437-1438　1998/05

DOI： 10.1016/S0140-6736(05)79486-1 　

ISSN： 0140-6736
Characterization of VP6 subgroup, VP7 and VP4 genotype of rotavirus strains in Lusaka, Zambia

A. D. Steele, A. D. Steele, F. C. Kasolo, P. Bos, I. Peenze, H. Oshitani, E. Mpabalwani

Annals of Tropical Paediatrics　18　111-116　1998/01/01

DOI： 10.1080/02724936.1998.11747936 　

ISSN： 0272-4936
Laboratory diagnosis of acute measles infections in hospitalized children in Zambia Peer-reviewed

H Oshitani, H Suzuki, M Mpabalwani, K Mizuta, FC Kasolo, NP Luo, Y Numazaki

TROPICAL MEDICINE & INTERNATIONAL HEALTH　2　(7)　612-616　1997/07

ISSN： 1360-2276
Epidemiology of influenza virus infections in children with acute respiratory infections in Zambia Peer-reviewed

K Mizuta, H Oshitani, M Saijo, EM Mpabalwani, FC Kasolo, NP Luo, H Suzuki, Y Numazaki

ANNALS OF TROPICAL PAEDIATRICS　17　(2)　115-119　1997/06

ISSN： 0272-4936
Measles case fatality by sex, vaccination status, and HIV-1 antibody in Zambian children Peer-reviewed

H Oshitani, H Suzuki, ME Mpabalwani, K Mizuta, Y Numazaki

LANCET　348　(9024)　415-415　1996/08

ISSN： 0140-6736
Prevalence of hepatitis B antigens in human immunodeficiency virus type 1 seropositive and seronegative pregnant women in Zambia Peer-reviewed

H. Oshitani, F. C. Kasolo, M. Mpabalwani, K. Mizuta, N. P. Luo, H. Suzuki, Y. Numazaki

Transactions of the Royal Society of Tropical Medicine and Hygiene　90　(3)　235-236　1996
Publisher: Oxford University Press
DOI： 10.1016/S0035-9203(96)90227-8 　

ISSN： 0035-9203
Hepatitis B virus infection among pregnant women in Zambia Peer-reviewed

H Oshitani, F Kasolo, C Tembo, M Mpabalwani, K Mizuta, N Luo, H Suzuki, Y Numazaki

EAST AFRICAN MEDICAL JOURNAL　72　(12)　813-815　1995/12

ISSN： 0012-835X
LOW-PREVALENCE OF HEPATITIS-C VIRUS-INFECTION IN LUSAKA, ZAMBIA Peer-reviewed

H OSHITANI, F KASOLO, NP LUO, M MPABALWANI, K MIZUTA, N NUMATA, H SUZUKI, Y NUMAZAMKI

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE　89　(4)　380-380　1995/07

ISSN： 0035-9203
MEASLES INFECTION IN HOSPITALIZED CHILDREN IN LUSAKA, ZAMBIA Peer-reviewed

H OSHITANI, M MPABALWANI, F KASOLO, K MIZUTA, NP LUO, GJ BHAT, H SUZUKI, Y NUMAZAKI

ANNALS OF TROPICAL PAEDIATRICS　15　(2)　167-172　1995/06

ISSN： 0272-4936
AN OUTBREAK OF INFLUENZA A/H3N2 IN A ZAMBIAN SCHOOL DORMITORY Peer-reviewed

K MIZUTA, H OSHITANI, EM MPABALWANI, FC KASOLO, NP LUO, H SUZUKI, Y NUMAZAKI

EAST AFRICAN MEDICAL JOURNAL　72　(3)　189-190　1995/03

ISSN： 0012-835X
ROTAVIRUS GASTROENTERITIS IN HOSPITALIZED CHILDREN WITH ACUTE DIARRHEA IN ZAMBIA Peer-reviewed

M MPABALWANI, H OSHITANI, F KASOLO, K MIZUTA, N LUO, N MATSUBAYASHI, G BHAT, H SUZUKI, Y NUMAZAKI

ANNALS OF TROPICAL PAEDIATRICS　15　(1)　39-43　1995

ISSN： 0272-4936
ASSOCIATION OF ROTAVIRUS AND HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION IN CHILDREN HOSPITALIZED WITH ACUTE DIARRHEA, LUSAKA, ZAMBIA Peer-reviewed

H OSHITANI, FC KASOLO, M MPABALWANI, NP LUO, N MATSUBAYASHI, GH BHAT, H SUZUKI, Y NUMAZAKI, A ZUMLA, HL DUPONT

JOURNAL OF INFECTIOUS DISEASES　169　(4)　897-900　1994/04

ISSN： 0022-1899
ANTIVIRAL ACTIVITIES OF RIBAVIRIN, 5-ETHYNYL-1-BETA-D-RIBOFURANOSYLIMIDAZOLE-4-CARBOXAMIDE, AND 6'-(R)-6'-C-METHYLNEPLANOCIN-A AGAINST SEVERAL ORTHOVIRUSES AND PARAMYXOVIRUSES Peer-reviewed

S SHIGETA, S MORI, M BABA, M ITO, K HONZUMI, K NAKAMURA, H OSHITANI, Y NUMAZAKI, A MATSUDA, T OBARA, S SHUTO, E DECLERCQ

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY　36　(2)　435-439　1992/02

DOI： 10.1128/AAC.36.2.435 　

ISSN： 0066-4804

Show all ︎Show first 5

Misc. 211

地球温暖化地球規模で考える環境と健康

岩田敏, 有吉紅也, 押谷仁, 苅和宏明, 橋爪真弘

Modern Media　68　(7)　283-308　2022/07
Publisher: 栄研化学(株)
ISSN： 0026-8054
当院の新型コロナウイルス変異株の検出状況および感染性リスク評価における発症日とCt値の関連性

中山麻美, 岡本道子, 馬場啓聡, 金森肇, 押谷仁

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　71st-69th　2022
Roles of Public Health Centers and Cluster-Based Approach for COVID-19 Response in Japan

Tadatsugu Imamura, Tomoya Saito, Hitoshi Oshitani

Health Security　19　(2)　229-231　2021/04

DOI： 10.1089/hs.2020.0159 　

ISSN： 2326-5094

eISSN： 2326-5108
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施と分析

辻一郎, 押谷仁, 八重樫伸生, 永富良一, 井樋栄二, 富田博秋, 菅原由美, 萩原嘉廣, 矢部裕, 関口拓矢, 松本和紀, 佐久間篤, 瀬戸萌, 内海裕介, 臼倉瞳

宮城県における東日本大震災被災者の健康状態等に関する調査令和元年度総括・分担研究報告書(Web)　2020
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施と分析

辻一郎, 遠又靖丈, 菅原由美, 丹治史也, 大塚達以, 松元浩一, 押谷仁, 富田博秋, 松本和紀, 八重樫伸生, 永富良一, 井樋栄二, 萩原嘉廣, 佐々木啓一, 小坂健, 相田潤, 奥山純子, 金村政輝, 粟田主一, 鈴木玲子, 曽根稔雅

宮城県における東日本大震災被災者の健康状態等に関する調査平成30年度総括・分担研究報告書(Web)　2019
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施と分析

辻一郎, 遠又靖丈, 菅原由美, 丹治史也, 大塚達以, 阿部喜子, 押谷仁, 神垣太郎, 松岡洋夫, 松本和紀, 八重樫伸生, 永富良一, 井樋栄二, 萩原嘉廣, 関口拓矢, 富田博秋, 佐々木啓一, 小坂健, 相田潤, 金村政輝, 粟田主一, 鈴木玲子, 曽根稔雅

宮城県における東日本大震災被災者の健康状態等に関する調査平成29年度総括・分担研究報告書(Web)　2018
宮城県における東日本大震災被災者の健康状態等に関する調査生活環境の推移とその影響に関する検討

押谷仁, 菅原由美, 辻一郎, 遠又靖丈, 関口拓矢, 丹治史也, 大塚達以

宮城県における東日本大震災被災者の健康状態等に関する調査平成29年度総括・分担研究報告書(Web)　2018
【グローバル化・温暖化と感染症対策】感染対策としてのイベントベース・サーベイランス

押谷仁

小児科臨床　70　(増刊)　2117-2121　2017/12
Publisher: (株)日本小児医事出版社
ISSN： 0021-518X
フィリピンの小児呼吸器疾患症例におけるエンテロウイルスD68の疫学的・臨床的解析

齊藤麻理子, 小畑, 岡本道子, 齊藤繭子, Chaimongkol Natthawan, 玉記雷太, Lupisan Socorro, 押谷仁

グローバルヘルス合同大会プログラム・抄録集　2017　314-314　2017/11
Publisher: グローバルヘルス合同大会事務局
国境を越えるウイルス SARS・MERSなどの新興ウイルス感染症の日本へのリスクとその対応

押谷仁

臨床とウイルス　45　(4)　161-165　2017/10
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
Association of Rotavirus and Human Immunodeficiency Virus Infection in Children Hospitalized with Acute Diarrhea, Lusaka, Zambia (vol 169, pg 897, 1994)

H. Oshitani, F. C. Kasolo, M. Mpabalwani, N. P. Luo, N. Matsubayasbi, G. H. Bhat, H. Suzuki, Y. Numazaki, A. Zumla, H. L. DuPont

JOURNAL OF INFECTIOUS DISEASES　215　(10)　1629-1629　2017/05

DOI： 10.1093/infdis/jix217 　

ISSN： 0022-1899

eISSN： 1537-6613
【今、蚊を考える-蚊媒介感染症に関する最近の話題】蚊媒介感染症に関する最近の話題黄熱

押谷仁

臨床と微生物　44　(3)　257-262　2017/05
Publisher: (株)近代出版
ISSN： 0910-7029
国境を越えるウイルス SARS・MERSなどの新興ウイルス感染症の日本へのリスクとその対応

押谷仁

臨床とウイルス　45　(2)　S12-S12　2017/04
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
小児におけるライノウイルスの地理的分布および5歳未満の同胞における感染リスク

佐藤彩加, 神垣太郎, 岡本道子, 玉記雷太, 押谷仁

感染症学雑誌　91　(臨増)　260-260　2017/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
フィリピンビリラン島でのRespiratory Syncytial Virus(RSV)感染症の感染伝播の疫学

乙丸礼乃, 神垣太郎, 玉記雷太, 岡本道子, 押谷仁

感染症学雑誌　91　(臨増)　380-380　2017/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
【臨床ウイルス分野の海外協力】新興感染症に対する国際的な流行対応における日本の役割

押谷仁

臨床とウイルス　45　(1)　14-17　2017/03
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
当科で経験したEV-D68感染症17例の臨床的検討 RSV感染症32例との比較

目時嵩也, 岡本道子, 鈴木陽, 三浦舞子, 渡邊庸平, 野口里恵, 大沼良一, 貴田岡節子, 押谷仁, 久間木悟

日本小児科学会雑誌　121　(2)　317-317　2017/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施と分析

辻一郎, 遠又靖丈, 菅原由美, 渡邉崇, 海法悠, 丹治史也, 大塚達以, 村上綾, 押谷仁, 神垣太郎, 松岡洋夫, 松本和紀, 八重樫伸生, 永富良一, 井樋栄二, 萩原嘉廣, 関口拓矢, 富田博秋, 佐々木啓一, 小坂健, 相田潤, 金村政輝, 粟田主一, 鈴木玲子, 曽根稔雅

宮城県における東日本大震災被災者の健康状態等に関する調査平成28年度総括・分担研究報告書(Web)　9‐14 (WEB ONLY)　2017
【国際的に脅威となる感染症】エンテロウイルスD68(EV-D68)感染症

押谷仁

化学療法の領域　33　(2)　267-273　2017/01
Publisher: (株)医薬ジャーナル社
ISSN： 0913-2384
当科で経験したエンテロウイルスD68(EV-D68)感染症17例の臨床的検討 RSウイルス感染症32例との比較

目時嵩也, 三浦舞子, 宮林広樹, 六郷由佳, 佐藤大記, 渡邊庸平, 野口里恵, 大沼良一, 渡邉浩司, 貴田岡節子, 久間木悟, 岡本道子, 押谷仁, 大宮卓, 佐藤光, 西村秀一, 鈴木陽

日本小児科学会雑誌　121　(1)　123-123　2017/01
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
【進化する感染症】新興感染症に対する世界の備え

押谷仁

チャイルドヘルス　19　(12)　878-881　2016/12
Publisher: (株)診断と治療社
ISSN： 1344-3151
【新興・再興感染症-グローバル化に伴う注目すべき感染症-】グローバリゼーションと新興感染症

押谷仁

日本臨床　74　(12)　1956-1961　2016/12
Publisher: (株)日本臨床社
ISSN： 0047-1852
SARI(重症急性呼吸器感染症)サーベイランスの必要性

押谷仁

臨床とウイルス　44　(4)　160-163　2016/10
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
【エンテロウイルスD68と関連疾患】エンテロウイルスD68の受容体と抗原性

古瀬祐気, 押谷仁

臨床とウイルス　44　(3)　79-83　2016/07
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
【エンテロウイルスD68と関連疾患】エンテロウイルスD68感染症に関する海外情報

水田克巳, 古瀬祐気, ナタワン・チャイモンコン, 押谷仁

臨床とウイルス　44　(3)　112-120　2016/07
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
感染症法に含まれない感染症のサーベイランス Event-based surveillance(EBS)の意義 sARIサーベイランスの必要性

押谷仁

臨床とウイルス　44　(2)　S18-S18　2016/05
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
グローバル社会における感染症グローバルな新興感染症の脅威

押谷仁

東京女子医科大学雑誌　86　(2)　56-60　2016/04
Publisher: 東京女子医科大学学会
ISSN： 0040-9022
流入下水監視によるノロウイルス感染症発生動向調査

風間しのぶ, 三浦尚之, 今田義光, 真砂佳史, 当广謙太郎, 真中太佳史, 相馬奈央, 今川稔文, 鈴木陽, LIU Xiaofang, 斉藤繭子, 中山大典, 押谷仁, 大村達夫

日本水環境学会年会講演集　50th　471　2016/03/10
繰り返される急性呼吸器感染症の危険因子に関する、起因ウイルスに基づく解析(コホート研究)

古瀬祐気, 岡本道子, 押谷仁

感染症学雑誌　90　(臨増)　265-265　2016/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
仙台市における2015年9月から10月のエンテロウイルスD68を含む呼吸器ウイルスの流行

岡本道子, 大宮卓, 佐藤光, 伊藤洋子, 西村秀一, 押谷仁, 久間木悟, 貴田岡節子

感染症学雑誌　90　(臨増)　266-266　2016/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
宮城県における東日本大震災被災者の健康状態等に関する調査生活環境の推移とその影響に関する検討

押谷仁, 丹治史也, 辻一郎, 遠又靖丈, 菅原由美, 渡邉崇, 杉山賢明, 本藏賢治, 海法悠, 神垣太郎, 三村敬司

宮城県における東日本大震災被災者の健康状態等に関する調査平成27年度総括・分担研究報告書　14‐26　2016
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施

辻一郎, 遠又靖丈, 菅原由美, 渡邉崇, 杉山賢明, 本藏賢治, 海法悠, 丹治史也, 大塚達以, 村上綾, 押谷仁, 神垣太郎, 三村敬司, 松岡洋夫, 松本和紀, 八重樫伸生, 永富良一, 井樋栄二, 萩原嘉廣, 関口拓矢, 富田博秋, 南優子, 佐々木啓一, 小坂健, 相田潤, 金村政輝, 粟田主一, 鈴木玲子, 曽根稔雅

宮城県における東日本大震災被災者の健康状態等に関する調査平成27年度総括・分担研究報告書　9‐13　2016
【インフルエンザとその対策】鳥インフルエンザの動向

古瀬祐気, 押谷仁

日本胸部臨床　74　(12)　1352-1357　2015/12
Publisher: 克誠堂出版(株)
ISSN： 0385-3667
新型インフルエンザと危機管理

押谷仁

日本臨床微生物学雑誌　26　(Suppl.)　95-95　2015/12
Publisher: (一社)日本臨床微生物学会
ISSN： 0917-5059
中東呼吸器症候群(MERS) (特集ウイルス感染症との新たな戦い : グローバル化する脅威の克服を目指して)

押谷仁

医薬ジャーナル　51　(11)　87-90　2015/11
Publisher: 医薬ジャーナル社
ISSN： 0287-4741
【ウイルス感染症との新たな戦い〜グローバル化する脅威の克服を目指して〜】中東呼吸器症候群(MERS)

押谷仁

医薬ジャーナル　51　(11)　2575-2578　2015/11
Publisher: (株)医薬ジャーナル社
ISSN： 0287-4741
我が国の健康危機管理におけるEBSの効果的な研修のあり方―研修前後アンケート調査

金成由美子, 中島一敏, 中島一敏, 中島一敏, 中島一敏, 吉田眞紀子, 吉田眞紀子, 砂川富正, 八幡裕一郎, 鈴木智之, 谷口清州, 緒方剛, 金谷泰宏, 齋藤智也, 角野文彦, 押谷仁, 神垣太郎, 加來浩器

日本公衆衛生学会総会抄録集　74th　462-462　2015/10/15
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
THE PREVALENCE AND GENETIC DIVERSITY OF SAPOVIRUS IN A NESTED CASE-CONTROL STUDY OF A PERUVIAN PERI-URBAN COMMUNITY

Xiaofang Liu, Holger Mayta, Robert H. Gilman, Michiko Okamoto, Lilia Cabrera, Jean E. Crabtree, Vitaliano Cama, Mayuko Saito, Hitoshi Oshitani

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE　93　(4)　443-443　2015/10

ISSN： 0002-9637

eISSN： 1476-1645
沖縄における夏季のインフルエンザ流行とその理由

押谷仁

日本医事新報　(4764)　63-64　2015/08
Publisher: (株)日本医事新報社
ISSN： 0385-9215
グローバル社会における感染症グローバルな新興感染症の脅威

押谷仁

東京女子医科大学雑誌　85　(4)　144-144　2015/08
Publisher: 東京女子医科大学学会
ISSN： 0040-9022
Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections (vol 25, pg 102, 2015)

Tadatsugu Imamura, Hitoshi Oshitani

REVIEWS IN MEDICAL VIROLOGY　25　(4)　268-268　2015/07

DOI： 10.1002/rmv.1844 　

ISSN： 1052-9276

eISSN： 1099-1654
海外勤務と健康管理グローバリゼーションと感染症リスク

押谷仁

交通医学　69　(3-4)　62-63　2015/07
Publisher: 日本交通医学会
ISSN： 0022-5274
【感染症最前線とグローバル・ヘルス】いま注目のウイルス感染症世界規模で再興するエンテロウイルス68

今村忠嗣, 押谷仁

医学のあゆみ　253　(1)　81-88　2015/04
Publisher: 医歯薬出版(株)
ISSN： 0039-2359
【「感染症研究国際ネットワーク推進プログラム(J-GRID)」10年のあゆみ】「国境なき感染症に備える知のネットワーク(J-GRID)」の10年を振り返る

光山正雄, 平山謙二, 押谷仁, 永井美之

最新医学　70　(4)　677-692　2015/04
Publisher: (株)最新医学社
ISSN： 0370-8241
海外勤務と健康管理グローバリゼーションと感染症のリスク

押谷仁

交通医学　69　(1-2)　1-1　2015/03
Publisher: 日本交通医学会
ISSN： 0022-5274
【せまりくる鳥インフルエンザの脅威】鳥インフルエンザへの対応

押谷仁

臨牀と研究　91　(12)　1551-1553　2014/12
Publisher: 大道学館出版部
ISSN： 0021-4965
フィリピン共和国タクロバン市において下痢症患者および河川水中から検出されたロタウイルスの遺伝子型解析

今川稔文, 山本大, 齋藤繭子, GAYLON Ruel, 齋藤麻理子, 真砂佳史, ANGULO Rhodora, HIJADA Jonathan R, MERCADO Edelwisa S, LUPISAN Socorro P, 押谷仁

日本ウイルス学会学術集会プログラム・抄録集　62nd　269　2014/10/31
Research activities and responding to typhoon Haiyan (Yolanda): Tohoku-RITM collaborating research center in the Philippines

Mariko Saito, Mayuko Saito, Tadatsugu Imamura, Taro Kamigaki, Socorro P. Lupisan, Hitoshi Oshitani

Journal of Disaster Research　9　(5)　823-827　2014/10/01
Publisher: Fuji Technology Press
DOI： 10.20965/jdr.2014.p0823 　

ISSN： 1881-2473
次世代シーケンサーを用いた下水モニタリングと感染性胃腸炎サーベイランスによるノロウイルス流行状況の比較

風間しのぶ, 真砂佳史, 当广謙太郎, 相馬奈央, 今川稔文, 鈴木陽, LIU Xiaofang, 斉藤繭子, 押谷仁, 大村達夫

日本水環境学会シンポジウム講演集　17th　223-224　2014/09/08
ノロウイルスGI,GII群を対象とした定量PCR法の比較

真砂佳史, 風間しのぶ, 今川稔文, 当广謙太郎, 斉藤繭子, 鈴木陽, 押谷仁, 大村達夫

日本水環境学会シンポジウム講演集　17th　225-226　2014/09/08
【インフルエンザUpdate】世界と日本のインフルエンザ対策

押谷仁

小児科臨床　67　(9)　1471-1475　2014/09
Publisher: (株)日本小児医事出版社
ISSN： 0021-518X
【感染症研究国際ネットワーク研究の現状】海外拠点におけるウイルス感染症研究フィリピン共和国拠点

押谷仁, 齊藤麻理子, 神垣太郎, 岡本道子, 玉記雷太, 斉藤繭子

化学療法の領域　30　(6)　1266-1273　2014/05
Publisher: (株)医薬ジャーナル社
ISSN： 0913-2384
新たな呼吸器ウイルスの出現とリスクアセスメント鳥インフルエンザH7N9とMERS

押谷仁

日本化学療法学会雑誌　62　(3)　385-386　2014/05
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007
今後の鳥インフルエンザとパンデミックへの対応今後のパンデミック対策とリスクアセスメント

押谷仁

日本化学療法学会雑誌　62　(Suppl.A)　157-157　2014/05
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007
学校における感染対応インフルエンザ対策における学校の役割秋田県医師会感染症等危機管理委員会アドバイザー

押谷仁

沖縄県医師会報　50　(2)　125-125　2014/02
Publisher: (一社)沖縄県医師会
ISSN： 0917-1428
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施概要

辻一郎, 菅原由美, 遠又靖丈, 柿崎真沙子, 福地成, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 海法悠, 小暮真奈, 伊藤久美子, 押谷仁, 神垣太郎, 三村敬司, 松岡洋夫, 松本和紀, 富田博秋, 八重樫伸生, 永富良一, 須藤彰子, 井樋栄二, 萩原嘉廣, 南優子, 佐々木啓一, 小坂健, 相田潤, 金村政輝, 粟田主一, 鈴木玲子

宮城県における東日本大震災被災者の健康状態等に関する調査平成25年度総括研究年度終了報告書　11-18　2014
宮城県における東日本大震災被災者の健康状態等に関する調査生活環境の推移とその影響に関する検討

押谷仁, 辻一郎, 遠又靖丈, 菅原由美, 柿崎真沙子, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 神垣太郎, 三村敬司

宮城県における東日本大震災被災者の健康状態等に関する調査平成25年度総括研究年度終了報告書　19-31　2014
中部ベトナムにおけるRSV‐A ON1遺伝子型の発生と小児呼吸器疾患の重症化の関連性

吉原圭亮, MHLH Le Nhat, 樋泉道子, 岡本道子, 押谷仁, 鈴木基, 森内浩幸, 橋爪真弘, ANH Dang Duc, 有吉紅也, 吉田レイミント

日本小児感染症学会総会・学術集会プログラム・抄録集　46th　258　2014
【インフルエンザに立ち向かう】パンデミックインフルエンザ

押谷仁

Mebio　30　(12)　16-20　2013/12
Publisher: (株)メジカルビュー社
ISSN： 0910-0474
【2013年感染症の流行と新展開】感染症トピックスウイルス鳥インフルエンザと新型インフルエンザ

押谷仁

Medical Technology　41　(12)　1278-1281　2013/12
Publisher: 医歯薬出版(株)
ISSN： 0389-1887
【グローバル化する感染症の最新情報】グローバル化する感染症の脅威にどう立ち向かうべきか

押谷仁

臨牀と研究　90　(12)　1657-1661　2013/12
Publisher: 大道学館出版部
ISSN： 0021-4965
"新型インフルエンザ等"の法的規制を考える公衆衛生の立場から考える新型インフルエンザ対策

押谷仁

感染症道場　2　(4)　53-56　2013/10
Publisher: (株)メディカルレビュー社
ISSN： 2186-8034
感染症対策に資する社会接触パターンに関する調査解析

神垣太郎, 押谷仁

日本公衆衛生学会総会抄録集　72回　199-199　2013/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
【大規模災害に備えた公衆衛生対策のあり方】大規模災害において想定される保健医療福祉の課題感染症の観点から

押谷仁, 神垣太郎

保健医療科学　62　(4)　364-373　2013/08
Publisher: 国立保健医療科学院
ISSN： 1347-6459
315 Characteristics of cold plasma flow for viral inactivation

Kudo Yuji, Okamoto Michiko, Sato Takehiko, Yoshino Daisuke, Suzuki Akira, Oshitani Hitoshi

Symposium on Environmental Engineering　2013　(23)　220-221　2013/07/09
Publisher: The Japan Society of Mechanical Engineers

More details Close

In recent years, pandemic outbreak due to a mutation of virus is paid close attention as a big problem that may collapse social order. Generally, the methods for preventing and healing disease by the virus depend on medical agents s uch as the vaccine or antiviral drug. However, the vaccine and antiviral drug could be poorly supplied when the pandemic occurred. Plasma has been proven to be capable of sterilizing bacteria and expected to inactivate the virus. In this study, we focused on the effect of chemical species generated by plasma flow on influenza viruses.
コロナウイルスと重症急性呼吸器感染症 SARS出現から10年、そして新型コロナウイルスの出現と今後の課題

押谷仁

小児感染免疫　25　(2)　185-188　2013/07
Publisher: 日本小児感染症学会
ISSN： 0917-4931
【東日本大震災、巨大津波、原発事故がわれわれに遺した課題】東日本大震災後の感染症への対応何が機能し何が機能しなかったのか

押谷仁, 三村敬司, 神垣太郎

臨床とウイルス　41　(3)　148-155　2013/07
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
【海外拠点におけるウイルス感染症研究】フィリピンにおける東北大学のウイルス研究の取り組み

押谷仁, 齊藤麻理子, 岡本道子, 玉記雷太, 神垣太郎, 鈴木陽

ウイルス　63　(1)　45-50　2013/06
Publisher: 日本ウイルス学会
ISSN： 0042-6857

eISSN： 1884-3433
新型インフルエンザに立ち向かう

押谷仁

東京内科医会会誌　28　(3)　224-227　2013/04
Publisher: (一社)東京内科医会
ISSN： 0914-9503
新型インフルエンザへの対応

押谷仁

日本環境感染学会誌　28　(Suppl.)　123-123　2013/02
Publisher: (一社)日本環境感染学会
ISSN： 1882-532X
宮城県における東日本大震災被災者の健康状態等に関する調査被災地高齢者の生活機能の推移:石巻市雄勝地区・牡鹿地区の実態

辻一郎, 遠又靖丈, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 平野かよ子, 松岡洋夫, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健, 粟田主一

宮城県における東日本大震災被災者の健康状態等に関する調査平成24年度総括・分担研究報告書　96-102　2013
宮城県における東日本大震災被災者の健康状態等に関する調査被災者の生活習慣の変化とその影響に関する検討

平野かよ子, 菅原由美, 辻一郎, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健

宮城県における東日本大震災被災者の健康状態等に関する調査平成24年度総括・分担研究報告書　32-38　2013
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施概要

辻一郎, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 平野かよ子, 神垣太郎, 三村敬司, 松岡洋夫, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健, 富田博秋, 松本和紀, 金村政輝, 相田潤, 粟田主一

宮城県における東日本大震災被災者の健康状態等に関する調査平成24年度総括・分担研究報告書　13-22　2013
宮城県における東日本大震災被災者の健康状態等に関する調査生活環境の推移とその影響に関する検討

押谷仁, 辻一郎, 神垣太郎, 三村敬司, 中原篤史, 佐藤紀子, 柿崎真沙子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 平野かよ子, 松岡洋夫, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健

宮城県における東日本大震災被災者の健康状態等に関する調査平成24年度総括・分担研究報告書　23-31　2013
宮城県における東日本大震災被災者の健康状態等に関する調査東日本大震災被災者のメンタルヘルスの推移

松岡洋夫, 柿崎真沙子, 辻一郎, 中原篤史, 佐藤紀子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 平野かよ子, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健, 富田博秋, 松本和紀, 粟田主一

宮城県における東日本大震災被災者の健康状態等に関する調査平成24年度総括・分担研究報告書　39-47　2013
Recent trend of influenza at global level, including avian and swine influenza

22　(6)　485-489　2012/12
Publisher: 科学評論社
ISSN： 1884-2887
【震災医療-来るべき日への医療者としての対応】《その他》避難所における公衆衛生対応

押谷仁

内科　110　(6)　1107-1111　2012/12
Publisher: (株)南江堂
ISSN： 0022-1961
【新型インフルエンザは再びおこるか】我が国の新型インフルエンザ対策

押谷仁

臨牀と研究　89　(12)　1683-1686　2012/12
Publisher: 大道学館出版部
ISSN： 0021-4965
新興呼吸器感染症としてのエンテロウイルス68

押谷仁, 今村忠嗣

感染症　42　(5)　189,180-194,180　2012/09
Publisher: アステラス製薬(株)
ISSN： 0301-259X
【国際感染症対策の現状と課題】新興感染症の研究および対策の現状と課題世界と日本

押谷仁

公衆衛生　76　(8)　601-604　2012/08
Publisher: (株)医学書院
ISSN： 0368-5187
307 Inactivation of MDCK cell viability by exposure to plasma

Kudo Yuji, Suziki Akira, Sato Takehiko, Oshitani Hitoshi

Symposium on Environmental Engineering　2012　(22)　205-206　2012/07/03
Publisher: The Japan Society of Mechanical Engineers

More details Close

Influenza pandemic is one of the biggest threats to not only human being but also other living beings, such as birds and cows. Air cleaners using plasma have been commercialized and expec ted to prevent infection of virus, although their effect has not been verified yet. Plasma has been proven to be capable of sterilizing pathogenic bacteria with low temperature, low cost and safely, but the effect of plasma on virus inactivation has not been known yet because the authorized verification protcol for plasma inactivation method has not been established. At present, a method to transmit the virus to cells is used as an inspection method. To apply this inspection method to the verification protocol, it is necessary to examine the influence of the plasma on cell viability.In this study, we focused on how the chemical species generated by a plasma flow have effects on viability of MDCK cells, which will be used as a host cell.
東北大学地域保健支援センター活動報告

中原篤史, 佐藤眞理, 佐藤紀子, 渡邉崇, 柿崎真沙子, 遠又靖丈, 高橋英子, 菅原由美, 曽根稔雅, 周婉てい, 小坂健, 福地成, 松岡洋夫, 永富良一, 八重樫伸生, 南優子, 平野かよ子, 押谷仁, 辻一郎

東北公衆衛生学会誌　(61)　48-48　2012/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
【クローズアップ感染症】 <小児感染症領域における国際貢献>感染症コントロールの国際舞台で働くために

押谷仁

小児内科　44　(7)　1190-1194　2012/07
Publisher: (株)東京医学社
ISSN： 0385-6305
Characterization of Coxsackievirus A20 as the donor strain at the nonstructural region of the recombinant type 1 circulating vaccine-derived polioviruses in the Philippines

L. N. Apostol, H. Shimizu, A. Naeem, A. Suzuki, S. Lupisan, M. Saito, R. Olveda, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　16　E68-E68　2012/06

DOI： 10.1016/j.ijid.2012.05.168 　

ISSN： 1201-9712
東日本大地震後の感染症対応について東日本大震災後の感染症への対応何が機能し、何が機能しなかったのか

押谷仁

臨床とウイルス　40　(2)　S35-S35　2012/05
Publisher: 日本臨床ウイルス学会
ISSN： 0303-8092
東北大学地域保健支援センターの活動報告

坪谷透, 佐藤眞理, 柿崎真沙子, 永井雅人, 遠又靖丈, 渡邉崇, 周婉てい, 菅原由美, 丹治史也, 星玲奈, 金村政輝, 平野かよ子, 押谷仁, 松岡洋夫, 八重樫伸生, 永富良一, 南優子, 佐々木啓一, 辻一郎

宮城県公衆衛生学会会誌　(44)　12-12　2012/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
【東日本大震災から1年保健師が受け止めたもの】保健衛生システム復興のために東北大学地域保健支援センターの立ち上げと活動

佐藤眞理, 辻一郎, 押谷仁, 平野かよ子

保健師ジャーナル　68　(3)　200-205　2012/03
Publisher: (株)医学書院
ISSN： 1348-8333
【災害後の医療の課題-東日本大震災の経験を活かして-】自然災害発生後の感染症のリスクとその対応

押谷仁

Geriatric Medicine　50　(3)　291-295　2012/03
Publisher: (株)ライフ・サイエンス
ISSN： 0387-1088
第一回宮城県東日本大震災被災者健康診査:中間報告

佐藤眞理, 柿崎真沙子, 坪谷透, 渡邊崇, 遠又靖丈, 高橋英子, 永井雅人, 菅原由美, CHOU Wan‐Ting, 丹治史也, 星玲奈, 曽根稔雅, 松尾兼幸, 松岡洋夫, 永富良一, 八重樫伸生, 南優子, 平野かよ子, 押谷仁, 辻一郎, 柿崎真沙子, 坪谷透, 渡邊崇, 遠又靖丈, 高橋英子, 永井雅人, 菅原由美, CHOU Wan‐Ting, 丹治史也, 星玲奈, 曽根稔雅, 松尾兼幸, 松岡洋夫, 永富良一, 八重樫伸生, 南優子, 押谷仁, 辻一郎

J Epidemiol　22　(Supplement 1)　73　2012/01/26

ISSN： 0917-5040
乾燥濾紙血液を用いたラオス中部における小児B型肝炎の有病率調査と感染経路に関する考察

駒田謙一, 蜂矢正彦, 木多村知美, VONGPHRACHANH Phengta, XEUATVONGSA Anonh, 脇田隆宇, 溝上雅史, 押谷仁

日本国際保健医療学会学術大会プログラム・抄録集　27th　2012
Infectious disease risk after the Great East Japan Earthquake

Satoshi Mimura, Taro Kamigaki, Hitoshi Oshitani

Journal of Disaster Research　7　(6)　741-745　2012
Publisher: Fuji Technology Press
DOI： 10.20965/jdr.2012.p0741 　

ISSN： 1883-8030 1881-2473
東日本大震災被災者の健康状態等に関する調査宮城県調査

辻一郎, 佐藤眞理, 柿崎真沙子, 高橋英子, 永井雅人, 曽根稔雅, 福地成, 坪谷透, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邊崇, 星玲奈, 丹治史也, 平野かよ子, 押谷仁, 松岡洋夫, 八重樫伸生, 永富良一, 南優子, 佐々木啓一, 小坂健, 松本和紀, 富田博秋, 金村正輝, 相田潤, 粟田主一

東日本大震災被災者の健康状態等に関する調査平成23年度総括・分担研究報告書　209-219　2012
新型インフルエンザ発生時の公衆衛生対策の再構築に関する研究インフルエンザ対策に関する文献調査およびウェブ構築に関する研究

押谷仁, 砂川富正, 斉藤玲子, 和田耕治, 神垣太郎, 菖蒲川由郷

新型インフルエンザ発生時の公衆衛生対策の再構築に関する研究平成23年度総括・分担研究報告書　41-74　2012
マニラ首都圏における台風Ketsanaによる洪水域内環境水からの病原性レプトスピラの検出

沼澤聡, 真砂佳史, 齊藤麻理子, 山口諒, 押谷仁, 大村達夫

環境工学研究論文集　48　III.165-III.171　2011/11/25

ISSN： 1341-5115
【インフルエンザ-その現状と対応-】インフルエンザ流行の世界的動向

押谷仁

化学療法の領域　27　(12)　2642-2649　2011/11
Publisher: (株)医薬ジャーナル社
ISSN： 0913-2384
Interruption of the circulation of an indigenous measles genotype and the introduction of other genotypes after a mass vaccination campaign in the Philippines. (vol 83, pg 1424, 2011)

N. Fuji, A. Suzuki, M. Saito, R. Centeno, H. Galang, S. Lupisan, R. Olveda, Hitoshi Oshitani

JOURNAL OF MEDICAL VIROLOGY　83　(10)　1866-1866　2011/10

DOI： 10.1002/jmv.22212 　

ISSN： 0146-6615
台風Ketsanaによる洪水試料からの病原性レプトスピラの検出

沼澤聡, 真砂佳史, 齊藤麻理子, 山口諒, 押谷仁, 大村達夫

土木学会年次学術講演会講演概要集(CD-ROM)　66th　ROMBUNNO.VII-014　2011/08/05
抗ウイルス能を有する新規多孔性材料の開発と評価

蛭子貴文, 久保拓也, 岡本道子, 鈴木陽, 押谷仁, 伊藤晴香, 細矢憲

日本分析化学会講演要旨集　60年会　289-289　2011/08
Publisher: (公社)日本分析化学会
震災後のインフルエンザウイルスモニタリング

当广謙太郎, 大谷可菜子, 岡本道子, 神垣太郎, 鈴木陽, 川村和久, 中川洋, 押谷仁

東北公衆衛生学会誌　(60)　20-20　2011/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
新型インフルエンザに立ち向かう

押谷仁

環境工学総合シンポジウム講演論文集　2011　(21)　1-2　2011/06/29
Publisher: 一般社団法人日本機械学会
グローバル化する感染症の脅威にどう立ち向かうべきか

押谷仁

中部大学生命健康科学研究所紀要　7　1-12　2011/03
Publisher: 中部大学生命健康科学研究所
ISSN： 1880-3040
感染症のup-to-date 現況と対策新型インフルエンザへの対応とその課題

押谷仁

日本医科大学医学会雑誌　7　(1)　35-35　2011/02
Publisher: 日本医科大学医学会
ISSN： 1349-8975
学校での集団感染シナリオから考える感染症対策 (特集この冬,備えておきたい学校の感染症対策--インフルエンザの再流行に備えて)

神垣太郎, 押谷仁

教職研修　39　(4)　104-107　2010/12
Publisher: 教育開発研究所
新型インフルエンザ対策は有効であったのか (特集新型インフルエンザAH1N1の流行を振り返って)

押谷仁

臨牀と研究　87　(12)　1671-1674　2010/12
Publisher: 大道学館出版部
ISSN： 0021-4965
政策新型インフルエンザ対策の評価--わが国と諸外国との違い

玉記雷太, 神垣太郎, 押谷仁

インフルエンザ　11　(4)　345-351　2010/10
Publisher: メディカルレビュー社
ISSN： 1345-8345
【パンデミックインフルエンザ最新の知見と今後の展望】世界と我が国の新型インフルエンザ(H1N1)2009の教訓 (日本臨床)

神垣太郎, 玉記雷太, 押谷仁

日本臨床　68　(9)　1605-1610　2010/09
Publisher: 日本臨床社
ISSN： 0047-1852
【検証「パンデミックインフルエンザ2009」】パンデミックインフルエンザ(H1N1)2009の流行の疫学的特徴 (公衆衛生)

押谷仁

公衆衛生　74　(8)　647-651　2010/08
Publisher: 医学書院
DOI： 10.11477/mf.1401101865 　

ISSN： 0368-5187
【新型インフルエンザパンデミックを経験して課題とこれからの対策】平成21年H1N1新型インフルエンザその臨床的特徴 (医学と薬学)

貫和奈央, 神垣太郎, 押谷仁

医学と薬学　63　(6)　853-860　2010/06
医療に関連するトピックス新型インフルエンザ (理学療法ジャーナル)

玉記雷太, 押谷仁

理学療法ジャーナル　44　(4)　333-333　2010/04
Publisher: (株)医学書院
ISSN： 0915-0552

eISSN： 1882-1359
Molecular epidemiology of rhinoviruses among children diagnosed as severe pneumonia in the Philippines

N. Fuji, A. Suzuki, S. Lupisan, R. Tamaki, M. Saito, A. De Leon, R. Olveda, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　14　E472-E472　2010/03

DOI： 10.1016/j.ijid.2010.02.667 　

ISSN： 1201-9712
Etiology of childhood pneumonia in Tacloban, the Philippines

A. Suzuki, S. Lupisan, N. Fuji, A. Ohno, Y. Furuse, R. Tamaki, M. Saito, H. Oreste, M. Mondoy, L. Sombrero, A. De Leon, R. Olveda, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　14　E27-E27　2010/03

DOI： 10.1016/j.ijid.2010.02.1547 　

ISSN： 1201-9712
Influenza disease burden study on 2 sentinel sites of Mongolia, 2008/09 season

N. Nukiwa, A. Burmaa, T. Naranzul, T. Kamigaki, B. Darmaa, B. Gantsooj, H. Oshitani, P. Nymadawa

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　14　E84-E85　2010/03

DOI： 10.1016/j.ijid.2010.02.1676 　

ISSN： 1201-9712
Mixed infection of influenza A viruses is common

Y. Furuse, A. Suzuki, N. Nukiwa, N. Fuji, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　14　E319-E319　2010/03

DOI： 10.1016/j.ijid.2010.02.2199 　

ISSN： 1201-9712
Detection waterborne diseases associated viruses in the river water Metro Manila and Bulacan, the Philippines

T. Imagawa, A. Suzuki, M. Saito, Y. Masago, C. Okumura, S. Lupisan, R. Olveda, T. Omura, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　14　E63-E63　2010/03

DOI： 10.1016/j.ijid.2010.02.1628 　

ISSN： 1201-9712
新型インフルエンザ対策を考える新型インフルエンザ対策の現状と課題 (宮城県公衆衛生学会会誌)

押谷仁

宮城県公衆衛生学会会誌　(42)　15-18　2010/03
【新型インフルエンザ】新型インフルエンザA(H1N1)の世界的現状について (呼吸器内科)

神垣太郎, 押谷仁

呼吸器内科　17　(1)　6-13　2010/01
【どうする今冬のインフルエンザ】新型インフルエンザA(H1N1)の世界動向 (臨床とウイルス)

神垣太郎, 押谷仁

臨床とウイルス　38　(1)　130-135　2010/01
【インフルエンザ】新型インフルエンザの出現と世界的現状 (最新医学)

玉記雷太, 神垣太郎, 押谷仁

最新医学　65　(1)　26-36　2010/01
Publisher: (株)最新医学社
ISSN： 0370-8241
2008～2009シーズンの庄内地域におけるインフルエンザ外来患者からみた医療施設への負荷の検討新型インフルエンザA(H1N1)を視野に入れて

貫和奈央, 神垣, 太郎, 橋本, 亜希子, 河村, 真人, 玉記, 雷太, 押谷仁

0 : いいえ　84　(1)　52-58　2010/01
Publisher: 感染症学雑誌
DOI： 10.11150/kansenshogakuzasshi.84.52 　

ISSN： 0387-5911

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To make up for the lack of data on influenza-like illness (ILI), we studied patterns among 6,828 ILI patients seen at 34 healthcare facilities during the 2008-2009 influenza season in Shonai, Yamagata, Japan. Healthcare facilities were classified into 1) hospitals, 2) pediatric clinics, 3) internal medicine and pediatric clinics, 4) internal medicine clinics, and 5) others. The majority went to hospitals, but the highest percentage in all outpatient visits was 13.7％seen at pediatric clinics during the peak epidemiological week. Based on estimated incidence and hospitalization data for pandemic (H1N1) 2009 from Ministry of Health, Labour and Welfare, Japan, we estimated the number of ILI patients at 59,600-89,400 and the number hospitalized for pandemic (H1N1) 2009 at 895-2,240 in Shonai. If those with ILI follow the same consultation patterns as outpatients in the 2008?09 influenza season, this indicates an estimated 23,800-35,700 with ILI will go to hospitals and 20,040-30,060 to pediatric clinics during the H1N1 pandemic. This in turns means that an urgent need will arise for appropriate measures reducing this potentially huge burden during pandemic (H1N1) 2009 outbreak in Japan.
インフルエンザパンデミック(H1N1)2009を考える (ウイルス)

押谷仁

ウイルス　59　(2)　139-144　2009/12
Publisher: The Japanese Society for Virology
DOI： 10.2222/jsv.59.139 　

ISSN： 0042-6857

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In the past, influenza pandemics have been occurring every 20 to 30 years. Highly pathogenic avian influenza A(H5N1) has been causing unprecedented global outbreaks since 2003 and many human cases with a high case fatality rate have also been reported. But the virus that caused a pandemic in 2009 was A(H1N1) that was originated from swine influenza. The same subtype, A(H1N1) has been circulating in human population since 1977. This pandemic (H1N1) 2009 is also not as virulent as A(H5N1) in humans. Many aspects of pandemic (H1N1) 2009 are different from what we had been expecting. We should reconsider the concepts and the strategies for influenza pandemic by reviewing current pandemic (H1N1)
【インフルエンザとは何か】新型インフルエンザの疫学 (Biophilia)

玉記雷太, 神垣太郎, 押谷仁

Biophilia　5　(4)　14-20　2009/12
Publisher: アドスリー
【インフルエンザ 2009年パンデミックの理解とその後への応用】パンデミックインフルエンザ対策パンデミックに対応するための国際協調 (治療学)

玉記雷太, 神垣太郎, 押谷仁

治療学　43　(11)　1197-1200　2009/11
Publisher: ライフサイエンス出版(株)
ISSN： 0386-8109
公衆衛生 NPI(non-pharmaceutical intervention) (インフルエンザ)

玉記雷太, 神垣太郎, 押谷仁

インフルエンザ　10　(4)　315-321　2009/10
Publisher: メディカルレビュー社
ISSN： 1345-8345
【インフルエンザとワクチンをめぐって】インフルエンザをめぐる最新情報インフルエンザ流行のわが国と世界の情勢 (診断と治療)

玉記雷太, 神垣太郎, 押谷仁

診断と治療　97　(10)　2027-2031　2009/10
Publisher: 診断と治療社
ISSN： 0370-999X
【新型(豚)インフルエンザ禍からの教訓】新型インフルエンザパンデミックの特徴およびその対策 (化学療法の領域)

神垣太郎, 貫和奈央, 橋本亜希子, 玉記雷太, 押谷仁

化学療法の領域　25　(10)　2060-2066　2009/09
Publisher: (株)医薬ジャーナル社
ISSN： 0913-2384
【新型インフルエンザA(H1N1)対策医療現場のストラテジー】新型インフルエンザ対応戦略のコンセプト (感染対策ICTジャーナル)

玉記雷太, 神垣太郎, 押谷仁

感染対策ICTジャーナル　4　(Suppl.1)　7-12　2009/09
Publisher: (株)ヴァンメディカル
ISSN： 1881-4964
【待ったなしの感染症対策】新型インフルエンザ対策保健師が知っておきたいこと (保健師ジャーナル)

玉記雷太, 神垣太郎, 押谷仁

保健師ジャーナル　65　(9)　714-720　2009/09
Publisher: 医学書院
DOI： 10.11477/mf.1664101254 　

ISSN： 1348-8333
【検証・新型インフルエンザパンデミック対策を問い直す】新型インフルエンザへの対応専門家はこうみる (日本医事新報)

鈴木宏, 押谷仁, 岡部信彦

日本医事新報　(4452)　33-45　2009/08
Publisher: 日本医事新報社
ISSN： 0385-9215
医療機関におけるインフルエンザ感染の拡大について新型インフルエンザ大流行時における医療対応に関する疫学研究 (化学療法の領域)

神垣太郎, 橋本亜希子, 押谷仁

化学療法の領域　25　(8)　1755-1760　2009/07
SARSはこうして制御された

押谷仁

臨床とウイルス　37　(2)　S29　2009/04/30

ISSN： 0303-8092
公衆衛生世界各国における新型インフルエンザ対策の現状 (インフルエンザ)

玉記雷太, 神垣太郎, 押谷仁

インフルエンザ　10　(2)　133-141　2009/04
Publisher: メディカルレビュー社
ISSN： 1345-8345
【神経系の再興感染症と輸入感染症】新型インフルエンザと脳炎・脳症 (BRAIN and NERVE: 神経研究の進歩)

玉記雷太, 神垣太郎, 押谷仁

BRAIN and NERVE: 神経研究の進歩　61　(2)　153-160　2009/02
Publisher: 医学書院
ISSN： 1881-6096
小児インフルエンザ罹患者の便からのインフルエンザウイルスの検出

鈴木陽, 齊藤麻理子, 藤直子, 清水みどり, 押谷仁, 阿部修一, 板野正敬, 井上重夫, 遠藤晃彦, 加納一毅, 萱場潤, 嘉山益子, 川村和久, 関信夫, 田山利幸, 速水俊三, 松本文子, 目時規公也, 師保之, 八木恒夫, 山本克哉, 吉田眞

日本小児科学会雑誌　113　(1)　155-155　2009/01
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
わが国における新型インフルエンザの流行 (インフルエンザ)

玉記雷太, 神垣太郎, 押谷仁

インフルエンザ　10　(1)　33-37　2009/01
Publisher: メディカルレビュー社
ISSN： 1345-8345
【新型インフルエンザ・パンデミック予測と対策】 WHOの新型インフルエンザ対策 (日本医師会雑誌)

押谷仁

日本医師会雑誌　137　(10)　2091-2095　2009/01
Publisher: 日本医師会
ISSN： 0021-4493
【新型インフルエンザ・パンデミック予測と対策】狼は来るのか?その対策は新型インフルエンザ徹底討論 (日本医師会雑誌)

永井美之, 押谷仁, 田代眞人, 伊藤善典, 工藤宏一郎, 梅田珠実, 河岡義裕, 大日康史, 飯沼雅朗

日本医師会雑誌　137　(10)　2023-2044　2009/01
Publisher: 日本医師会
ISSN： 0021-4493
Detection of Human Metapneumovirus and Human Bocavirus from Patients with Influenza-Like Illness in the Philippines

A. Suzuki, Y. Furuse, H. Galang, N. Fuji, T. Kamigaki, E. Miranda, S. Lupisan, R. Olveda, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　12　E100-E101　2008/12

DOI： 10.1016/j.ijid.2008.05.251 　

ISSN： 1201-9712
Influenza Related Excess Mortality Estimates Among All Cause Deaths in Mongolia, 2004-2007

B. Alyeksandr, T. Kamigaki, H. Oshitani, N. Pagbajabun

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　12　E90-E90　2008/12

DOI： 10.1016/j.ijid.2008.05.225 　

ISSN： 1201-9712
Emergence of New Genotypes of Measles Virus in the Philippines After a Mass Vaccination

N. Fuji, A. Suzuki, T. Kamigaki, M. Saito, Y. Furuse, E. Miranda, S. Lupisan, R. Olveda, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　12　E100-E100　2008/12

DOI： 10.1016/j.ijid.2008.05.250 　

ISSN： 1201-9712
Seasonality and Phylogenic Analysis of Influenzavirus in Philippines, 2006-2007

H. Galang, A. Suzuki, Y. Furuse, N. Fuji, M. Saito, T. Kamigaki, S. Lupisan, H. Oshitani, R. Olveda

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　12　E101-E101　2008/12

DOI： 10.1016/j.ijid.2008.05.252 　

ISSN： 1201-9712
Genetic Variation and Prevalence of Amantadine-Resistant Influenza A (H3N2) Viruses in Two Consecutive Seasons in Japan and the Philippines

Y. Furuse, A. Suzuki, T. Kamigaki, M. Saito, N. Fuji, H. Galang, S. Lupisan, R. Olveda, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　12　E102-E102　2008/12

DOI： 10.1016/j.ijid.2008.05.254 　

ISSN： 1201-9712
Review of Epidemiological Risk Factors of Measles Outbreak in Displaced Population

K. Kouadio, T. Kamigaki, M. Saito, A. Suzuki, H. Oshitani

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES　12　E103-E103　2008/12

DOI： 10.1016/j.ijid.2008.05.257 　

ISSN： 1201-9712
【新型インフルエンザと季節性インフルエンザ】新型インフルエンザ新型インフルエンザは防げるか? (臨牀と研究)

玉記雷太, 神垣太郎, 押谷仁

臨牀と研究　85　(12)　1705-1710　2008/12
Publisher: 大道学館出版部
ISSN： 0021-4965
【呼吸器症候群(第2版) その他の呼吸器疾患を含めて】感染症呼吸器疾患ウイルス感染症新型インフルエンザ(H5N1インフルエンザ) (日本臨床)

玉記雷太, 押谷仁

日本臨床　別冊　(呼吸器症候群I)　108-114　2008/12
Publisher: (株)日本臨床社
ISSN： 0047-1852
グローバル化時代のウイルス感染症--WHOの視点から見た新型インフルエンザ (特集・新型インフルエンザの流行とその対策)

押谷仁

医薬ジャ-ナル　44　(11)　93-96　2008/11
Publisher: 医薬ジャ-ナル社
ISSN： 0287-4741
新型インフルエンザ対策と自治体の役割 (特集市民を守る自治体)

玉記雷太, 押谷仁

地方自治職員研修　41　(11)　27-30　2008/11
Publisher: 公職研
ISSN： 1341-3929
【流行を食い止める新型インフルエンザ】新型インフルエンザへのグローバルな取り組み (Mebio)

玉記雷太, 押谷仁

Mebio　25　(11)　83-91　2008/11
Publisher: (株)メジカルビュー社
ISSN： 0910-0474
【新型インフルエンザその対策】新型インフルエンザとは (成人病と生活習慣病)

玉記雷太, 押谷仁, 神垣太郎

成人病と生活習慣病　38　(11)　1229-1236　2008/11
Publisher: 東京医学社
ISSN： 1347-0418
【"感染症"と医療機関】新型インフルエンザにどう対応するか (保険診療)

玉記雷太, 押谷仁, 神垣太郎, 古瀬祐気

保険診療　63　(11)　15-21　2008/11
Publisher: (株)医学通信社
ISSN： 0385-8588
【新型インフルエンザの流行とその対策】グローバル化時代のウイルス感染症 WHOの視点から見た新型インフルエンザ (医薬ジャーナル)

押谷仁

医薬ジャーナル　44　(11)　2585-2588　2008/11
【変貌する感染症人類の備えは十分か?】新型インフルエンザへの備え (綜合臨床)

玉記雷太, 押谷仁

綜合臨床　57　(11)　2604-2610　2008/11
Publisher: 永井書店
ISSN： 0371-1900
【新型インフルエンザパンデミックに備えて】近づく新型インフルエンザ・パンデミックの脅威 (保団連)

玉記雷太, 押谷仁

保団連　(982)　11-18　2008/10
Publisher: 全国保険医団体連合会
ISSN： 0288-5093
新型インフルエンザに対する公衆衛生上の対策 (インフルエンザ)

玉記雷太, 神垣太郎, 押谷仁

インフルエンザ　9　(4)　299-305　2008/10
Publisher: メディカルレビュー社
ISSN： 1345-8345
気候変動と感染症・疾病リスクの関連性 (特集地球を蝕む気候変動)

齊藤麻理子, 押谷仁

都市問題　99　(9)　28-34　2008/09
Publisher: 東京市政調査会
ISSN： 0387-3382
新型インフルエンザへの対応世界的な見地から (感染制御)

玉記雷太, 押谷仁

感染制御　4　(3)　263-266　2008/05
Publisher: (株)EDIXi出版部
鳥インフルエンザ(H5N1)感染症の現況と対策 (日本医事新報)

押谷仁

日本医事新報　(4385)　57-62　2008/05
Publisher: 日本医事新報社
ISSN： 0385-9215
グローバル化する新興感染症とその対応

押谷仁

交通医学　62　(1)　8-8　2008/03/15

ISSN： 0022-5274
新型インフルエンザ対策の現状と課題 (山形県医師会学術雑誌)

押谷仁

山形県医師会学術雑誌　35　52-76　2008/03
フィリピンにおける麻疹マスワクチンキャンペーン後の流行株のシフト (感染症学雑誌)

鈴木陽, 藤直子, 古瀬祐気, 齊藤麻理子, 神垣太郎, 押谷仁

感染症学雑誌　82　(臨増)　325-325　2008/03
【インフルエンザ診療のブレークスルー】グローバルな視点からみた新型インフルエンザ (臨床検査)

押谷仁

臨床検査　52　(1)　16-22　2008/01
Publisher: 医学書院
DOI： 10.11477/mf.1542101488 　

ISSN： 0485-1420
新型インフルエンザ対策に関するエビデンス何がわかっていて、何がわかっていないのか? (臨牀と研究)

押谷仁

臨牀と研究　84　(12)　1728-1729　2007/12
【新興・再興感染症の現状と予防】高病原性トリインフルエンザと新型インフルエンザ (保健の科学)

押谷仁

保健の科学　49　(10)　669-673　2007/10
Publisher: 杏林書院
ISSN： 0018-3342
【インフルエンザを取り巻く治療・予防の現状と課題】新型インフルエンザ出現の時期と出現後の対応 (Progress in Medicine)

押谷仁

Progress in Medicine　27　(10)　2307-2312　2007/10
【難敵ウイルスを知る感染拡大防止に備えて】ウイルス感染症の治療インフルエンザの治療と新型インフルエンザ対策 (薬事)

押谷仁

薬事　49　(11)　1659-1663　2007/10
Publisher: じほう
ISSN： 0016-5980
鳥インフルエンザ(H5N1)感染症の現況と今後 (日本内科学会雑誌)

押谷仁

日本内科学会雑誌　96　(9)　1987-1992　2007/09
Publisher: The Japanese Society of Internal Medicine
DOI： 10.2169/naika.96.1987 　

ISSN： 0021-5384
話題のウイルス鳥インフルエンザウイルス (Drug Delivery System)

押谷仁

Drug Delivery System　22　(5)　578-578　2007/09
東北大学大学院医学系研究科病理病態学講座微生物学分野

鈴木陽, 押谷仁

ウイルス　57　(1)　101-102　2007/06/22

ISSN： 0042-6857
グローバル化する新興感染症に対する危機管理体制 (岩手県立病院医学会雑誌)

押谷仁

岩手県立病院医学会雑誌　47　(1)　52-54　2007/06
【ウイルス性疾患の動向と最近の治療】ワクチンによって予防可能なウイルス感染症と海外旅行狂犬病、A型肝炎、黄熱など (クリニカ)

神垣太郎, 押谷仁

クリニカ　34　(3)　183-188　2007/05
日本の新型インフルエンザ対策の現状と課題 (日本化学療法学会雑誌)

押谷仁

日本化学療法学会雑誌　55　(Suppl.A)　41-41　2007/04
【ウイルス感染症】新型インフルエンザによるパンデミック (分子呼吸器病)

押谷仁

分子呼吸器病　11　(1)　19-24　2007/01
鳥インフルエンザと新型インフルエンザ (Medical Technology)

押谷仁

Medical Technology　35　(1)　57-61　2007/01
新型インフルエンザ対策の現状と今後の課題

押谷仁

日本臨床微生物学雑誌 = The journal of the Japanese Society for Clinical Microbiology　16　(4)　33-33　2006/12/25

ISSN： 0917-5059
21世紀の新興感染症と研究者の役割 (東北医学雑誌)

押谷仁

東北医学雑誌　118　(2)　137-138　2006/12
Publisher: 東北医学会
ISSN： 0040-8700
【インフルエンザ診療のすべてと新型インフルエンザ対策】新型インフルエンザに備える鳥インフルエンザをめぐる世界の状勢 (臨牀と研究)

押谷仁

臨牀と研究　83　(12)　1775-1779　2006/12
Publisher: 大道学館出版部
ISSN： 0021-4965
【人獣共通感染症としてのインフルエンザパンデミックへの対応】インフルエンザの流行と予防新型インフルエンザに対していかに備えるか (カレントテラピー)

押谷仁

カレントテラピー　24　(12)　1049-1053　2006/12
【インフルエンザ診療の新展開パンデミックを視野に入れた戦略】インフルエンザパンデミックに向けて臨床医の知っておくべきこととその役割 (内科)

川名明彦, 板村繁之, 押谷仁, 加地正郎

内科　98　(5)　877-891　2006/11
グローバルな新型インフルエンザ対策 (感染症)

押谷仁

感染症　36　(6)　224-228　2006/11
鳥インフルエンザ : SARSなどの新興ウイルス感染症の脅威と課題

押谷仁

臨床病理 = THE OFFICIAL JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE　54　5-5　2006/10/20

ISSN： 0047-1860
グローバル化する21世紀の新興感染症 (東北のコロニー)

押谷仁

東北のコロニー　(33)　41-47　2006/09
鳥インフルエンザA(H5N1)の現状と日本の新型インフルエンザ対策の課題 (公衆衛生)

押谷仁

公衆衛生　70　(9)　696-700　2006/09
Publisher: 医学書院
DOI： 10.11477/mf.1401100641 　

ISSN： 0368-5187
【感染制御におけるパラダイムシフト感染制御における新しい流れ・最新情報と将来展望】国際保健の観点からみた感染制御 WHOにおけるあらたな取組みと将来展望 (医学のあゆみ)

押谷仁

医学のあゆみ　218　(13)　1063-1066　2006/09
Publisher: 医歯薬出版
ISSN： 0039-2359
新型インフルエンザ (医学のあゆみ)

押谷仁

医学のあゆみ　218　(2)　174-175　2006/07
インフルエンザのアクションプラン(対策)について (Virus Report)

松本慶蔵, 押谷仁, 田代眞人, 河岡義裕

Virus Report　3　(1)　12-23　2006/05
Publisher: 医薬ジャーナル社
ISSN： 1349-6956
最新のWHOの新型インフルエンザ対策 (インフルエンザ)

押谷仁

インフルエンザ　7　(1)　47-51　2006/01
Publisher: メディカルレビュー社
ISSN： 1345-8345
【インフルエンザ】インフルエンザの流行の歴史と現在の世界の状況 (医薬ジャーナル)

押谷仁

医薬ジャーナル　41　(12)　2875-2880　2005/12
【これだけは知っておきたい国際感染症】アジアにおけるサーベイランス強化とアウトブレイク対応 (Modern Physician)

押谷仁

Modern Physician　25　(5)　504-507　2005/05
最近話題の新興・再興感染症における衛生学・公衆衛生学者の果たす役割 WHOの立場から (日本衛生学雑誌)

押谷仁

日本衛生学雑誌　60　(2)　216-216　2005/03

ISSN： 0021-5082
Influenza a (HSN1) in Asia: Current situation and WHO responses

Hitoshi Oshitani

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS　26　S33-S33　2005

ISSN： 0924-8579

eISSN： 1872-7913
Influenza A (HSN1) in Asia: Current Situation and WHO Responses

Hitoshi Oshitani

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS　26　S33-S33　2005

ISSN： 0924-8579

eISSN： 1872-7913
【新興再興感染症 SARSの教訓】 SARSの教訓 SARS制圧の国際協力 (からだの科学)

押谷仁

からだの科学　増刊　(新興再興感染症SARSの教訓)　37-41　2004/05
【検証「SARS」】世界の状況とWHOの対応 (公衆衛生)

押谷仁

公衆衛生　67　(11)　820-825　2003/11
Publisher: 医学書院
DOI： 10.11477/mf.1401100959 　

ISSN： 0368-5187
新型肺炎(Severe Acute Respiratory Syndrome:SARS)の経過と今後の課題 (新潟県医師会報)

押谷仁

新潟県医師会報　(643)　2-7　2003/10
WHOの新型インフルエンザ対策 (インフルエンザ)

押谷仁

インフルエンザ　4　(1)　51-57　2003/01
Publisher: メディカルレビュー社
ISSN： 1345-8345
西太平洋地域における感染症の現状と対策 (Current Concepts in Infectious Diseases)

尾身茂, 押谷仁

Current Concepts in Infectious Diseases　20　(4)　6-9　2001/12
【薬剤耐性菌をめぐる最近の話題】アマンタジン耐性インフルエンザウイルス特に本邦のアマンタジン耐性株出現状況 (臨床検査)

斎藤玲子, 押谷仁, 鈴木宏

臨床検査　45　(8)　884-887　2001/08
Publisher: 医学書院
DOI： 10.11477/mf.1542904843 　

ISSN： 0485-1420
新潟県の高齢者施設におけるインフルエンザワクチン接種の現状とその効果に関する研究

関奈緒, 押谷仁, 斉藤玲子

厚生の指標　48　(7)　28-33　2001/07
Publisher: 厚生統計協会
ISSN： 0452-6104
1986年から1998年までに山形で急性気道感染症の小児から分離されたアデノウイルス3型のHypervariable regionの遺伝子配列の安定性

水田克巳, 押谷仁, 勝島矩子

山形県衛生研究所報　(34)　11-14　2001
Publisher: 山形県衛生研究所
ISSN： 0513-4706
山形とザンビアで急性気道感染症の小児から分離されたアデノウイルス3型の制限酵素切断パターンによる比較--地域土着性について

水田克巳, Kasolo F.C., 押谷仁

山形県衛生研究所報　(34)　7-10　2001
Publisher: 山形県衛生研究所
ISSN： 0513-4706
WHOのインフルエンザ対策の特徴とその意義 (日本臨床)

押谷仁

日本臨床　58　(11)　2175-2178　2000/11
【高齢者へのインフルエンザワクチン接種について】高齢者へのインフルエンザワクチン接種とその効果高齢者施設での使用 (日本胸部臨床)

鈴木宏, 押谷仁, 斎藤玲子, 関奈緒, 田辺直仁

日本胸部臨床　59　(9)　662-669　2000/09
ワクチンインフルエンザウイルスワクチン接種と抗インフルエンザウイルス剤 (化学療法の領域)

鈴木宏, 斎藤玲子, 押谷仁, 増田寛樹

化学療法の領域　16　(増刊)　315-321　2000/04
Viral Emerging and Re-emerging Infections

Oshitani Hitoshi, Suzuki Hiroshi

114　(3)　77-82　2000/03
Publisher: 新潟医学会
ISSN： 0029-0440
新興・再興感染症ウイルス性新興・再興感染症 (新潟医学会雑誌)

押谷仁, 鈴木宏

新潟医学会雑誌　114　(3)　78-82　2000/03
インフルエンザワクチン現行ワクチンの評価とその問題点 (治療学)

鈴木宏, 押谷仁

治療学　34　(1)　81-85　2000/01
ANALYSIS OF ACTUAL COVERAGE OF THE IMMUNIZATION PROGRAM IN NIIGATA PREFECTURE AND DEVELOPMENT OF A SIMPLE ESTIMATION OF ITS COVERAGE

SEKI Nao, SAITO Reiko, TANABE Naohito, OSHITANI Hitoshi, SUZUKI Hiroshi

Japanese journal of public health　46　(11)　1013-1019　1999/11/15
Publisher: 日本公衆衛生学会
ISSN： 0546-1766
インフルエンザの治療と予防ワクチン (感染と抗菌薬)

鈴木宏, 押谷仁, 斎藤玲子

感染と抗菌薬　2　(3)　295-299　1999/09
インフルエンザ感染症の予防・制御対策 (新潟医学会雑誌)

鈴木宏, 押谷仁, 村山直也, 川崎聡, 斉藤玲子, 関奈緒, 田辺直仁

新潟医学会雑誌　113　(3)　133-137　1999/03
Publisher: Niigata University
ISSN： 0029-0440
ザンビアのウイルス感染症 A.小児感染症 (化学療法の領域)

沼崎義夫, 押谷仁, 水田克巳

化学療法の領域　13　(10)　1894-1901　1997/09
Measles infection in HIV seropositive children in Zambia

OSHITANI Hitoshi, SUZUKI Hiroshi, MPABALWANI Mwila, MIZUTA Katsumi, NUMAZAKI Yoshio

23　92-92　1995/10/20

ISSN： 0304-2146
公衆衛生活動の国際的な展開ザンビアにおけるウイルス性肝炎対策 (公衆衛生)

鈴木宏, 押谷仁

公衆衛生　58　(8)　544-546　1994/08
Publisher: 医学書院
DOI： 10.11477/mf.1401901087 　

ISSN： 0368-5187

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Books and Other Publications 15

臨床医のための呼吸器・消化管ウイルス感染症

札幌医科大学医学部小児科学講座教授, 堤, 裕幸ed, 押谷仁

診断と治療社　2014/08/28
医療機関における新型インフルエンザ等対策。ミニマム・エッセンシャルズ

川崎市健康安全研究所, 岡部, 信彦, d, 押谷仁

南山堂　2014/08/01
シンプル衛生公衆衛生学2014

群馬大学名誉教授, 鈴木庄亮, ed. 押谷

南山堂　2014/03/10
シンプル衛生公衆衛生学2013

群馬大学名誉教授, 鈴木庄亮, ed. 押谷

南山堂　2013/03/10
インフルエンザの最新知識Q&A2012 パンデミックＨ1Ｎ1 2009の終焉を迎えて～

新潟大学名誉教授, 鈴木宏, 東北大学加齢医学研究所教授, 渡辺彰, ed. 押谷

医薬ジャーナル社　2012/05/15
インフルエンザの最新知識Q&A2010 パンデミックＨ1Ｎ1 2009第一波を降り返って

新潟大学名誉教授, 鈴木宏, 長崎大学名誉教授, 松本, 慶蔵名誉教授, d. 押谷仁

医薬ジャーナル社　2010/08/10
パンデミックとたたかう

押谷仁, 瀬名秀明

岩波書店　2009/11/20
新型インフルエンザはなぜ恐ろしいのか。ＷＨＯで活躍する医師と最前線に立つジャーナリストが問題お本質を語りつくす。

押谷仁, 虫明秀樹

NHK出版　2009/09/10
新型インフルエンザ

佐藤元, 押谷仁

東海大学出版会　2009/02
インフルエンザの最新知識Q&A2009

新潟大学鈴木, 宏教授, 長崎大学松本, 慶蔵名誉教授, ed. 押谷

医薬ジャーナル社　2009/02
新型インフルエンザ健康危機管理の倫理と実際

岩崎恵美子, d. 押谷

東海大学出版社　2008/12/05
『KEY WORD 感染症』第2版

山口恵三, 戸塚恭一, s, 押谷仁

先端医学社　2008/08/01
今日の治療指針私はこう治療している 2008年度版

山口徹, 北原光夫, 福井次矢, 押谷仁

医学書院　2008/01
小児感染症学

岡部信彦, 押谷仁

診断と治療社　2007/09
Severe Acute Respiratory Syndrome

Malik Peiris、Larry J. Anderson、Albert, D. M. E. Osterhaus, Klaus Stohr, ed. Merianos A Condon, R, Oshitnai H Werker D, Andraghetti R

Blackwell Publishers　2005/11

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Presentations 113

グローバルからローカルへの感染症対策：エボラ・新型インフルエンザから地域内季節性インフルエンザ対策へ

大館市立総合病院地域関連感染対策セミナー　2015/03/04
新興感染症への地域の備え：西アフリカのエボラウイルス感染症の流行から見えてきた課題

平成26年度秋田県医師会感染症等危機管理研修会　2015/03/03
東北大学・フィリピン拠点の活動成果

感染症に備えるアジア・アフリカ「知のネットワーク」10年の歩み成果報告シンポジウム　2015/02/20
新興感染症の脅威とその対応

山形県獣医師会公衆衛生講習会　2015/02/19
新型インフルエンザなどの感染症危機管理への自治体の備え

東北ブロック感染症危機管理会議　2015/02/17
エボラウイルス感染症などの新興感染症に我々はどう備えたらいいのか

気仙沼市立病院講演会　2015/02/02
感染症危機管理のためのリスクマネジメントの考え方

平成２６年度日本公衆衛生学会・感染症事例のリスクアセスメント研修会　2014/11/07
フィリピンにおける小児急性呼吸器感染症に関する研究

第55 回日本熱帯医学会大会・第29 回日本国際保健医療学会学術大会・合同大会　2014/11/01
Recovery from the Great Tohoku Earthquake and Fukushima nuclear plant disaster International-presentation

NIH –Japan JSPS Symposium　2014/10/23
新たな感染症の脅威にどう対応したらいいのか

河北健康の医学教室　2014/10/21
新型インフルエンザの現状と課題

玉川医師会小児科医会学術講演会　2014/09/25
新型インフルエンザ等の新興感染症対策とリスクアセスメント

秋田県感染症研究会第71回例会　2014/09/16
新型インフルエンザ等の新興感染症対策とリスクアセスメント

第16回三重県院内感染対策研究会　2014/09/10
感染症危機管理と学校の役割

東京都教育庁健康づくりフォーラム　2014/07/31
今後のパンデミック対策とリスクアセスメント

第88回日本感染症学会学術講演会・第62回日本化学療法学会総会合同学会　2014/06/18
Globalization and Emerging Infectious Diseases International-presentation

The 93rd GRIPS Forum　2014/06/09
Epidemiology Of Influenza Infection Among Pregnant Women And Children Under 6 Months In Mongolia, 2013/14 Season: A Prospective Cohort Study International-presentation

Third ISIRV-Antiviral Group Conference ("Influenza and Other Respiratory Virus Infections: Advances in Clinical Management")　2014/06/04
フィリピンの台風30号（Yolanda）の被害とＪ-ＧＲＩＤ研究への影響

H26年度第1回ＪＩＣＡ国際緊急援助隊医療チーム課題検討会　2014/04/15
新型インフルエンザ等の感染症リスクマネジメントの課題

第11回感染症リスクマネジメント作戦講座　2014/03/19
フィリピンの台風被害に東日本大震災の経験をどう生かすか

日本公衆衛生学会東日本大震災後３年の復興活動の共有シンポジウム　2014/03/16
新型インフルエンザのリスクとその対応の課題

福島県医師会感染症危機管理研修会　2014/03/02
新型インフルエンザ等の感染症危機管理と自治体の課題

第7回東北ブロック感染症危機管理会議幹事会　2014/02/28
Infectious Diseases and Other Public Health Risks after the Typhoon Yolanda International-presentation

Asian-African Research Forum on Emerging and Reemerging Infections 2014　2014/01/20
Research projects in the Philippines International-presentation

The Asian Conference, Renewal of Our Commitment for Fighting against Communicable Diseases　2014/01/14
Chairperson International-presentation

The 18th Congress of Asian Pacific Society of Respirology　2013/11/14
インフルエンザ対策における学校の役割

秋田県医師会のシンポジウム「第44回全国学校保健・学校医大会」　2013/11/09
新たな呼吸器ウイルス出現とリスクアセスメン：鳥インフルエンザH7Ｎ9とMERS

第61回日本科学療法学、第56回日本感染症学会、第83回日本感染症学会　2013/11/06
Influenza pandemic preparedness and response in Japan International-presentation

Japan-Russia International Workshop 2013(JRIW2013)　2013/10/26
座長

第72回日本公衆衛生学会総会　2013/10/23
Molecular epidemiology of respiratory syncytial virus in three Asian countries: Japan, Mongolia and the Philippines International-presentation

The 14th National Virology Conference　2013/09/27
フィリピンにおける狂犬病

文部科学省・感染症研究国際ネットワーク推進プログラム（J-GRID）　2013/07/20
公衆衛生の立場から考える新型インフルエンザ対策

第87回日本感染症学学会. 第61回日本科学療法学会総会　2013/06/05
フィリピン重症肺炎の実態

J-GRIDプログラムで日本パスツール協会主催シンポジウム　2013/05/24
Evolution of Respiratory Viruses in Asia International-presentation

NIH-Tohoku University-JSPS Symposium. The 2nd Year Anniversary of the Great East Japan Earthquake, Present and Future　2013/05/09
Public health recovery after the Great East Japan Earthquake: Experiences in selected areas of Miyagi Prefecture International-presentation

International Conference on Health Sector Recovery from Disasters　2013/03/05
新型インフルエンザへの対応

第28回日本環境感染学会総会　2013/03/01
Moderator International-presentation

Asian-African Research Forum on Emerging and Reemerging Infections 2013　2013/01/23
Moderator International-presentation

NIH –Japan JSPS Symposium　2012/11/26
コロナウイルスと重症急性呼吸器感染症：SARS出現から１０年、そして新型コロナウイルスの出現と今後の課題

第44回日本小児感染症学会総会・学術集会　2012/11/24
海外拠点活動

第60回日本ウイルス学会学術集会　2012/11/13
大災害における感染症対策と公衆衛生上の課題

第71回日本公衆衛生学会総会　2012/10/24
Influenza surveillance in resource poor countries International-presentation

Pandemic influenza international conference　2012/09/05
感染症制御に向けての国際貢献：フィールドリサーチをどう感染症制御につなげるのか？

第5回小児感染症専門医育成フォーラム　2012/07/28
東日本大震災後の感染症への対応：何が機能し、何が機能しなかったのか

第53回日本ウイルス学会　2012/06/16
WHO Seasonal Influenza Vaccine Recommendations & Review of Vaccine Coverage International-presentation

APACI's Inaugural Asia-Pacific Influenza Summit　2012/06/12
公衆衛生危機管理：東日本大震災後の公衆衛生対応はどうあるべきだったのか

第57回大分県公衆衛生学会　2012/02/25
Infectious disease risk and public health recovery after the Great East Japan Earthquake International-presentation

Asian-African Research Forum on Emerging and Reemerging Infections 2012　2012/01/11
Infectious Disease Risk and Long-term Public Health Recovery after the Great East Japan Earthquake International-presentation

47th Joint Committee Meeting Japan – U.S. Cooperative Medical Science Program　2011/10/23
Infectious Disease Risk and Long-term Public Health Recovery after the Great East Japan Earthquake International-presentation

47th Joint Committee Meeting Japan – U.S. Cooperative Medical Science Program2011　2011/10/23
Epidemiology and etiological roles of two picornaviruses: human rhinovirus C and enterovirus 68 International-presentation

The 13th National Conference “Current Topics of Virology”　2011/09/09
Epidemiology and etiological roles of two picornaviruses: human rhinovirus C and enterovirus 68 International-presentation

The 13th National Conference “Current Topics of Virology”2011　2011/09/09
高病原性鳥インフルエンザの現状と課題

日本家禽学会2011年度秋季大会公開シンポジウム　2011/08/24
高病原性鳥インフルエンザの現状と課題

日本家禽学会H23年度秋季大会公開シンポジウム　2011/08/24
The Great East Japan Earthquake 2011: Health Impact and Recovery of Public Health Systems. Kobe Earthquake 1995 and Japan Earthquake and Tsunami of 2011 International-presentation

First Regional Health Cluster Forum on Humanitarian Emergencies　2011/08/22
新型インフルエンザに立ち向かう

第21回環境工学総合シンポ2011特別講演会　2011/06/30
クローバるな視点からみた感染症対策とフィールドリサーチの役割：フィリピン感染症研究拠点の経験から

第28回日本医学会総会2011東京　2011/04/09
インフルエンザ対策のエビデンス：わかっていることわかっていないこと

押谷仁

第26回日本環境感染症学会総会　2011/02/18
熱帯地で問題になる人獣共通感染症

押谷仁

第51回日本熱帯医学会大会　2010/12/04
新型インフルエンザA/H1N1の世界の状況と日本との比較

押谷仁

第42回日本小児感染症学会シンポジウム　2010/11/28
新型インフルエンザA/H1N1の世界の状況と日本との比較.

第58回日本ウイルス学会　2010/11/07
新型インフルエンザなどのグローバル化する感染症にどう立ち向かうのか

押谷仁

広島保健学会第7回学術集会　2010/10/03
Aetiology of severe acute respiratory tract infection in a rural area International-presentation

押谷仁

5th Annual Scientific Symposium, Stanley Ho Centre for Emerging Infectious Diseases, Hong Kong.　2010/06/29
Pandemic in Asia: Pandemic experiences and challenges beyond International-presentation

押谷仁

International Symposium on Influenza Pandemic in Asia　2010/03/23
Emerging infectious diseases in East Asia: Progress in strengthening capacity and unfilled gaps International-presentation

押谷仁

The conference on Strengthening Health and Non-Health Response Systems in Asia, Singapore　2010/03/18
Perspective on Planning for and Responding to the H1N1 Pandemic International-presentation

押谷仁

XII International Symposium on Respiratory Viral Infections, Chinese Taipei　2010/03/11
Translating data to information for policy formulation and implementation International-presentation

押谷仁

Experiences from regional Outbreaks. SEA Regional Conference on Epidemiology, New Delhi, India　2010/03/09
新型インフルエンザA(H1N1)：これまでの日本の対応と今後の課題

押谷仁

第19回IDATENインタラクティプ・ケースカンファレンス　2009/12/05
「インフルエンザパンデミックの基本とその対策」

押谷仁

第49回近畿産業衛生学会　2009/11/14
パンデミックインフルエンザ：ワクチンと抗ウイルス剤

押谷仁

第57回日本ウイルス学会学術集会　2009/10/26
新型インフルエンザについて

押谷仁

第63回国立病院総合医学会　2009/10/24
新型インフルエンザA(H1N1) 総論：世界の状況とわが国の対応

押谷仁

第68回公衆衛生学会総会　2009/10/21
「インフルエンザA(H1N1)による新型インフルエンザの予想される展開と課題」

押谷仁

第48回臨床呼吸器カンファレンス　2009/09/03
Pandemic preparedness and H1N1 pandemic severity assessment in southeast Asia International-presentation

押谷仁

The Lancet Conference in Influenza in the Asia-Pacific, Beijing China　2009/08/22
「新型インフルエンザの基礎知識とその対策」

押谷仁

第13回日本渡航医学会学術集会　2009/07/17
「新型インフルエンザ対策の現状と課題」

押谷仁

第45回宮城県公衆衛生学会学術総会　2009/06/25
インフルエンザA(H1N1)の世界の状況と日本での今後の展開

押谷仁

第50回日本臨床ウイルス学会　2009/06/14
インフルエンザA(H1N1)による新型インフルエンザの各国の状況と日本の課題

押谷仁

第49回日本呼吸器学会学術講演会　2009/06/13
WHOでの経験を含めて―感染症コントロールの国際舞台で働くために―

押谷仁

第83回日本感染症学会総会　2009/04/24
新型インフルエンザ対策の課題

押谷仁

平成20年度福島県自治体病院学会　2008/11/08
Influenza Pandemic Preparedness: Issues and Challenges International-presentation

押谷仁

Third Singapore Public Health & Occupational Medicine Conference, 16 & 17 Sep 2008　2008/09/16
クローバル化する新興感染症とその対応

押谷仁

第62回日本交通医学会総会　2008/06/07
新型新インフルエンザとは

押谷仁

日本医療学シンポジウム　2008/06/01
Influenza pandemic preparedness: WHO strategy and current situation in Japan International-presentation

押谷仁

7th Japan-China International Conference of Virology　2008/06/01
救急医療と感染症：呼吸器ウイルスアウトブレイクを中心として

押谷仁

第11回日本臨床救急医学会総会・学術集会　2007/06/07
「日本の新型インフルエンザ対策の現状と課題」

押谷仁

第55回日本化学療法学会総会　2007/06/01
「鳥インフルエンザ（H5N1)感染症の現況と今後」

押谷仁

第104回日本内科学会総会　2007/04/03
「グローバル化する新興感染症と日本の課題」

押谷仁

新潟県臨床衛生検査技師会学術研究会感染制御部門疫学領域分野研修会　2007/03/03
「新型インフルエンザ対策の現状と今後の課題」

押谷仁

第18回日本臨床微生物学会総会　2007/02/17
「グローバル化する新興感染症に対する危機管理体制」

押谷仁

平成18年度岩手県立病院医学会春季学術集会　2007/02/03
「小児科の視点から見た新型インフルエンザ対策の課題」

押谷仁

東北小児感染症懇話会　2007/01/20
「新型インフルエンザ対策に関するエビデンス：何がわかっていて、何がわかっていないのか？」

押谷仁

第９回九州感染症・化療フォーラム　2007/01/13
「インフルエンザA（H5N1)による鳥インフルエンザの現状と新型インフルエンザ対策の課題」

押谷仁

第二回奈良新興感染症研究会　2007/01/11
Overview of the current situation of avian influenza A(H5N1) and the risk of influenza pandemic International-presentation

押谷仁

11th Congress of the Asian Pacific Society of Respirology　2006/11/19
Possibility of Early Containment of Potential Influenza Pandemic International-presentation

押谷仁

U.S.-Japan Cooperative Medical Science Program (USJCMSP) 11th International Conference on Emerging Infectious Disease in the Pacific Rim　2006/11/16
鳥インフルエンザの現状と新型インフルエンザ対策の課題

押谷仁

第５回上越IC（Infection Control）フォーラム　2006/11/13
「鳥インフルエンザ、SARSなどの新興ウイルス感染症の脅威と課題」

押谷仁

第53回日本臨床検査医学会学術集会　2006/11/09
「新型インフルエンザにおけるWHOの対応と日本の対応」

押谷仁

公衆衛生学会　2006/10/27
Influenza pandemic threat and global and regional responses International-presentation

押谷仁

PANDEMIC INFLUENZA WORKSHOP Multilateral Perspectives on Preparedness Response Planning, and Areas for Cooperation　2006/09/27
鳥インフルエンザ問題を考える International-presentation

押谷仁

緊急国際シンポジウムもうひとつのアジア安全保障　2006/09/22
国際化と新興感染症

押谷仁

第89回日本輸血・細胞治療学会東北支部例会　2006/09/16
新型インフルエンザ対策の現状と問題点

押谷仁

第4回長崎感染症予防研究会　2006/09/15
鳥インフルエンザの現状とパンデミックの危険性

押谷仁

2006年度統計関連学会連合大会　2006/09/05
Overview and major issues for assessment of disease burden of viral diseases in Asia International-presentation

押谷仁

Vaccines for Viral Infections in Developing Countries　2006/07/27
新興ウイルス感染症の脅威

押谷仁

第５回みちのくウイルス塾　2006/07/15
新型インフルエンザ対策の現状と問題点

押谷仁

第5回総合診療フォーラム　2006/06/20
鳥インフルエンザA（H5N1）はパンデミックを起すか？

押谷仁

第7回感染病態シンポジウム　2006/06/13
新型インフルエンザのパンデミック現状と対策

押谷仁

第46回日本呼吸器学会学術講演会　2006/06/01
鳥インフルエンザの現状と国際的対応

押谷仁

第5回東北国際保健研究会学術総会　2006/04/22
Role of clinical research in prevention and control of emerging disease SARS and influenza

押谷仁

第109回日本小児科学会学術集会　2006/04/21
世界のインフルエンザパンデミック対策の最前線

押谷仁

第20回インフルエンザ研究者交流の会シンポジウム　2006/03/25
Overvew of avian influenza (H5N1) and pandemic threat International-presentation

押谷仁

新興・再興感染症に関するアジアリサーチフォーラム　2006/02/19
Collaboration in the fight against emerging viral infection: Asia Pacific perspective International-presentation

Oshitani, Hitoshi

5th Asia Pacific Congress of Medical Virology　2000/06/26
Regional Strategies for Emerging and Remerging Diseases

Oshitani, Hitoshi

SEAMIC Meeting on Surveillance and Control of Emerging Diseases　1999/12/02

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Research Projects 45

新型コロナウイルス感染症療養患者の健康管理アルゴリズム確立及び管理ツールの開発

石井正, 市川学, 植田琢也, 押谷仁, 赤石哲也

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

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令和3年度において実施した研究については、概ね交付申請書内の「研究方法・計画」に記載の通りの進捗となった。具体的には、宮城県内におけるCOVID-19宿泊療養施設一ヶ所（無症状者、軽症者を対象）で療養を行なった患者の療養時の記録（全て紙面情報、宮城県庁に保管）を、個人情報を扱うために本研究専用としたパソコンにデータベースとするべく記録し直した。登録された患者は2020年12月から2021年3月までで、計945人と当初の計画よりも順調に進行したため大幅に患者数を増やすことができた。個人を特定できる個人情報については、パスワードをかけたパソコンおよびファイル内にのみ格納しており、実際に解析を行うデータベースでは個人を特定できない形で扱っている。得られたデータは患者の基本情報（年齢、性別、基礎疾患、常用薬、COVID-19発症日、検査日、療養施設入所日・退所日、入院の有無等）および療養施設内での毎日の症状変化（体温、脈拍数、酸素飽和度、咳、痰、呼吸苦、胸痛、倦怠感、下痢、嘔気嘔吐、頭痛、鼻汁鼻閉、咽頭痛、筋肉関節痛、味覚嗅覚障害、食欲、不安感、不眠等）を10点満点のスケールで示したものである。また、東北大学病院総合診療科において往診を実施し、行われた検査や処方した薬剤、担当医の診察評価のデータも得られた。これらのデータは非常に詳細かつ信頼性が高く、入院患者以外の患者情報としては他に類を見ない貴重なデータであると思われる。これらの得られたデータから重症化リスクの高い療養者のトリアージ基準の策定や、症状が遷延するリスクの高い患者の同定を試みる。前者については、機械学習を応用した解析を実施中で、令和4年度前半には解析がまとまる見込みである。後者については、さまざまな因子の相互関係を考慮して実施しており、適切な統計解析によってこちらも令和4年度前半には解析がまとまる予定である。
Preparing for future pandemic of respiratory viruses based on epidemiological analysis of COVID-19

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2021/07/09 - 2023/03/31
Analysis of molecular evolution of various respiratory viruses in an area of the Philippines

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Institution: Tohoku University

2019/10/07 - 2023/03/31
Analysis of factors associated with global spread of enterovirus D68

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2019/06/28 - 2023/03/31
Epidemiological study for control of respiratory syncytial virus from a global perspective

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2019/04/01 - 2023/03/31
Urgent research on COVID-19 utilizing infectious disease research stations in Asia

MORITA Kouichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Special Purposes

Institution: Nagasaki University

2020/02/20 - 2021/03/31

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A novel COVID-19 diagnostic system that was developed using the LAMP method has been utilized in epidemic situations such as a COVID-19 outbreak on a cruise ship in Japan. In addition to this diagnostic system, a serological diagnostic ELISA system has also been developed using a genetically engineered viral N protein. The sensitivity and specificity of the ELISA system were 91.1% and 93.8% respectively, and it has been successfully employed nationally in Vietnam during outbreak control activities. Conventional virus neutralization tests need to use live viruses, which are pathogenic. We therefore developed a pseudo-virus system in order to safely measure virus neutralizing antibodies. We also conducted a molecular epidemiological study using a full-genome analysis of SARS-CoV-2 strains on a region wide scale and found that a variant, Q667H was expanding in Indonesia. This suggests the importance of continuous virus genome surveillance worldwide for better vigilance and management.
Development of a pre-education program for international support nurses during a pandemic

MATSUNAGA SANAE

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

2018/04/01 - 2021/03/31

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This study conducted semi-structured interviews on "difficulties and coping of nurses" with health care professionals who were responsible for international support during the Ebola outbreak, and qualitatively analyzed the results. The results of the qualitative analysis were used as a basis for developing a draft educational program for nurses who would be responsible for international support during a pandemic. The draft educational program was evaluated by experts in infection control, and improvements were made and developed into an educational program. The results of this study are more reliable because the draft program was developed based on qualitative research and evaluated by experts, and will be used in the future activities and education of nurses in the event of a pandemic.
宮城県における東日本大震災被災者の健康状態等に関する調査 Competitive

辻一郎

Offer Organization: 厚生労働省

System: 厚生労働科学研究費補助金

2013/04 - 2021/03
Establishing research network for control of childhood acute respiratory infections in Asia and Africa Competitive

OSHITANI Hitoshi

Offer Organization: Japan Society for the Promotion of Science

System: Core-to-Core Program, Asia-Africa Science Platforms

2017/04 - 2020/03
フィリピン感染症研究拠点における国際共同研究の推進 Competitive

押谷仁

Offer Organization: 日本医療研究開発機構（AMED)

System: 感染症研究国際展開戦略プログラム(J-GRID)

2015/04 - 2020/03
Cost-effectiveness analysis of revised Integrated Management of Childhood Illness (IMCI) guidelines for childhood pneumonia in the Philippines

TAMAKI RAITA, Tallo Vicky, Tan Alvin, Alday Portia, Lanbucho Jhoys, Donald Mark

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

2016/04/01 - 2019/03/31

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Cost-effectiveness analysis of revised Integrated Management of Childhood Illness (IMCI) guidelines for childhood pneumonia was conducted in the Philippines. There was equal effectiveness between the revised IMCI and the original IMCI. The treatment cost of pneumonia with the revised IMCI was significantly reduced by 53%. The results were discussed with the department of health for possible implantation in the Philippines. The evidence can be utilized for resource poor settings in the low and middle income countries with high burden of childhood pneumonia, which may contribute to UHC.
トランスミッションダイナミックスから見たRSウイルスの疫学と新たな対策の確立 Competitive

押谷仁

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(A)

2016/04 - 2019/03
Molecular Mechanisms a Novel Genotype of Respiratory Syncytial Virus Replaced Old One

Furuse Yuki, Oshitnai Hitoshi, Okamoto Michiko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

2016/04/01 - 2018/03/31

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Respiratory syncytial virus (RSV) is a major cause of bronchiolitis among young children. In the study project, we analyzed a new genotype of the virus, ON1. We identified genetic signature of the ON1 RSV by whole genome sequencing. Phylogenetic analysis with the sequence data revealed evolutionary pathway that the ON1 RSV had generated. Mathematical modelling found immunological difference and seasonality as factors responsible for replacement of circulating genotypes of the virus. We also found a phenotypic difference between the ON1 and a former genotype of the virus in infection model with isolated virus and human airway-derived cells. Further study would unveil molecular mechanisms underlying difference between the genotypes.
迅速・高精度・網羅的な病原微生物検出による水監視システムの開発 Competitive

大村達夫

Offer Organization: 科学技術振興機構

System: 戦略的創造研究推進事業

2011/10 - 2017/03
A Landscape Genetic Study of Dengue Vector Mosquitoes in The Philippines: Dispersal Pattern and Infection Route

Watanabe Kozo, OMURA Tatsuo, WATANABE Toru, OSHITANI Hitoshi, SAITO Mariko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Ehime University

2013/04/01 - 2016/03/31

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We assessed the spatial population genetic structure of dengue vector mosquito Aedes aegypti in Metro Manila and Tarlac city in the Philippines. The analysis inferred a strong dispersal activity of Ae aegypti based on the observed low genetic differentiation among populations. However, fine scale population structuring was also detected based on the generated dendrogram and the identification of 3 genetic populations. Based on auto-correlation among local populations, their flight distance was estimated < 5km. In addition, we also developed a GIS-based prediction model of local dengue risk focusing on flood intensity and land use classification in all 604 administrative district in Metro Manila. Using these data, we constructed a regression tree model that describes the spatial variation of dengue infection rate of the administrative section. The model was estimated with high accuracy, and flooding has also been shown that a high contribution as a risk factor.
アジアにおけるインフルエンザウイルスのトランスミッションダイナミックスと進化 Competitive

押谷仁

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(A)

2012/04 - 2016/03
小児呼吸器感染症の病因解析・疫学に基づく予防・制御に関する研究 Competitive

押谷仁

Offer Organization: 日本医療研究開発機構（AMED)

System: 地球規模課題対応国際科学技術協力プログラム(SATREPS)

2010/04 - 2016/03
フィリピンの新興・再興感染症研究拠点における国際共同研究 Competitive

OSHITANI Hitoshi

Offer Organization: Ministry of Education, Culture, Sports, Science and Technology

System: Japan Initiative for Global Research Network on Infectious Diseases (J-GRID)

2010/04 - 2015/03
新型インフルエンザ発生時の公衆衛生対策の再構築に関する研究 Competitive

OSHITANI Hitoshi

Offer Organization: Ministry of Health, Labor and Welfare

System: Health Labour Sciences Research Grant

2011/04 - 2014/03
高病原性の新型インフルエンザ発生に対する事前準備及び、緊急対応に関する研究 Competitive

田代真人

Offer Organization: 厚生労働省

System: 厚生労働科学研究費補助金

2011/04 - 2014/03
フィリピンにおけるヒトエンテロウイルスCの疫学解析とリスク評価 Competitive

押谷仁

Offer Organization: 日本学術振興会

System: 科学研究費助成事業挑戦的萌芽研究

2011/04 - 2013/03
熱帯東南アジアにおける新型インフルエンザH1N1による疾病負担ならびに超過死亡の研究 Competitive

2011/04 - 2013/03
被災地の保健機能復興と経験共有 Competitive

OSHITANI Hitoshi

Offer Organization: Sasakawa Peace Foundation

System: Sasakawa Peace Foundation Grant

2011/10 - 2012/03
アジアにおけるインフルエンザウイルスの疫学解析ネットワークの構築 Competitive

2009/04 - 2012/03
小児呼吸器感染症の病因および疫学解析に基づく予防・制御に関する研究 Competitive

2010/06 - 2011/03
新型インフルエンザＡ（Ｈ１Ｎ１）のトランスミッションダイナミックスから見た疫学像 Competitive

Offer Organization: 日本学術振興会

System: 科学研究費助成事業挑戦的萌芽研究

2010/04 - 2011/03
新型インフルエンザによるパンデミック対策と域内協力事業 Competitive

Offer Organization: Sasakawa Peace Foundation

System: Sasakawa Peace Foundation Grant

2009/04 - 2011/03
新型インフルエンザ大流行時の公衆衛生対策に関する研究 Competitive

押谷仁

Offer Organization: 厚生労働省

System: 厚生労働科学研究費補助金

2008/04 - 2011/03
急性呼吸器感染症の感染メカニズムと疫学、感染予防・制御に関する研究 Competitive

2006/04 - 2011/03
新型インフルエンザ対策における検疫の効果的・効率的な実施に関する研究 Competitive

2009/04 - 2010/03
開発途上国に対する新型インフルエンザサーベイランス及び対応能力強化支援の具体的あり方に関する研究 Competitive

2009/04 - 2010/03
フィリピンの新興・再興感染症研究拠点における国際共同研究 Competitive

2008/04 - 2010/03
感染症の病態別、迅速多項目診断システムの開発 Competitive

2008/04 - 2010/03
改正国際保健規制への対応体制構築に関する研究 Competitive

2008/04 - 2010/03
Rabies control in Bohol Island (Philippines)

SAITO Mariko, OSHITANI Hitoshi, SUZUKI Akira, KAMIGAKI Taro, REMIGIO M. Olveda

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2008 - 2010

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The aims of this study were to consist the monitoring system of the rabies in the Philippines and to conduct the molecular epidemiology analysis using the animal brain samples collected from each region in the country. As the result of the genetic analysis, we found out 1) Since rabies virus has been imported to the Philippines, the transfer of the virus over the island were few 2) viruses were tend to be kept out in the geographically isolated area. 3) the control strategy conducted by the area might be effective for eliminate the rabies.
The study on disease burden of influenza in Mongolia

KAMIGAKI Taro, OSHITANI Hitoshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2008 - 2010

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Our initial study indicated that by using Serfling model to estimate an excess mortality associated with influenza was not detected a certain upsurge during 2004 to 2007. Then we conducted the enhanced influenza surveillance along with monitoring severe acute respiratory infections (sARI) in two sites, a suburb district of Ulaanbaatar and regional capital of northern region for 2008/09 and 2009/10 seasons. This surveillance studies demonstrated that most of influenza like illness (ILI) and sARI cases were found in children under five years and less in elders, that could explain the potential structure of small excess mortality associated with influenza. In summary, it is important to estimate the influenza burden not only by measuring the excess mortality but by using other indicators.
感染症アウトブレイクに対する効果的な国際協力のあり方に関する研究 Competitive

2007/04 - 2009/03
健康危機管理におけるクライシスコミュニケーションのあり方の検討 Competitive

2007/04 - 2009/03
日本におけるスペインインフルエンザ(1918-1920年)の疫学的解析

押谷仁, 神垣太郎, 鈴木陽

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的萌芽研究

Institution: 東北大学

2008 - 2009

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インフルエンザでは突然別の亜型が出現して流行することがあり、これをインフルエンザパンデミックという。過去100年間に発生した3回のパンデミックのうち最も被害が大きかったのは我々の研究で41万3000人(95%信頼区間76,717-480,357)の超過死亡がみられた1918年から1920年に起こったスペインインフルエンザである。中国大陸に駐留していた関東軍では1918年から1920年の致死率(死亡者数を感染者数で除したもの)でみるとそれぞれ1000人あたり5.0、7.8、7.2人であり、流行時期が後になるほど高い数字であった。またパンデミック(H1N1)2009の発生を受けて、流行像がより近いと示唆された1957年のアジアインフルエンザあるいは1968年の香港インフルエンザの時期に発行された新聞記事を用いてデータベースを作成した。アジアインフルエンザでは学校閉鎖および流行状況に対する報道姿勢が今回と似ていること、新聞の報道数では初期の動向と非常に相関が高いが、12月以降のインフルエンザシーズンでは動向と必ずしも一致しないことが明らかとなった。研究についてまとめると、スペインインフルエンザでは大きなMortality impactがみられたが、過去に検討された病理像は現在のウイルス性肺炎と矛盾しないものであつたが、細菌性肺炎の関与も強く疑われた。また流行初期よりも後期において致命率が上昇していたことも明らかとなった。1918年以外のパンデミックも含めてもやはり公衆衛生上において重要な課題であったことと考えられた。
Pilot study to develop an early warning system for emerging infectious diseases in developing countries

OSHITANI Hitoshi, SUZUKI Akira, KAMIGAKI Taro, OLVEDA Remigio M., TAYAG Enrique A., OSAKA Ken, SEKINE Masao, FURUSE Yuki, FUJI Naoko, KOUADIO Koffi Isidore, NUKIWA Nao, SAYAMA Yusuke, IMAGAWA Toshifumi, LEA NECITAS GUILLERMO Apostol, KHANDAKER Irona, FUTAKUCHI Naomi, MPOLYA Emmanuel Abraham

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2007 - 2009

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In the 21st century, there have been newly emerging infectious diseases such as severe acute respiratory syndrome (SARS) and pandemic influenza. Compared with ordinal epidemic prone diseases, recent emerging infectious diseases pose a greater threat at a global level. Therefore it is required to develop an efficient early warning system, which is consist of strengthen of routine surveillance as well as development of new systems. In this study, we revealed that active case findings can warrant an efficient outbreak response especially among displaced population. In addition, it is important to understand the background information in the countries when introducing new methodology available in developed counties. To improve laboratory confirmation in these settings, new methodologies including genetic detection and antibody detection methods shoulde be developed.
フィリピンにおける新興・再興感染症研究拠点形成に向け試行的共同研究 Competitive

2007/04 - 2008/03
新型インフルエンザへの事前準備と大流行発生時の緊急対応計画に関する研究 Competitive

2006/04 - 2008/03
フィリピンでの新興・再興感染症研究拠点形成のための予備調査 Competitive

2006/10 - 2007/03
地域での新型インフルエンザ対策の現状と対策推進に関する調査研究 Competitive

2006/04 - 2007/03
新型インフルエンザ発生時の対応に関する研究 Competitive

2005/04 - 2006/03

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第2回東北-新潟 exchange meeting

2013/12/06 - 2013/12/07

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Infectious disease risk after the typhoon Yolanda (Haiyan) in the Philippines.
[日本国内] 第8回日伊科学技術宮崎国際会議

2008/10/10 - 2008/10/11

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2006/11/11 - 2006/11/12

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講師および研究指導講習会名：「再教育・生涯教育講習会」主催：地域医療教育開発センター
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2014/09/16 -

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2014/09/10 -

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新型インフルエンザ等の新興感染症対策とリスクアセスメント
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2014/07/31 -

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2014/01/27 -

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2013/11/16 -

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2013/10/18 -

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2013/06/22 -

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2013/06/06 -

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2013/05/23 -

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2013/03/18 -

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2013/02/06 -

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2012/12/13 -

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2012/12/08 -

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2012/10/03 -

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2012/07/28 -

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2012/06/15 -

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2012/02/25 -

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2012/02/20 -

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被災時の感染症対策東日本大震災などの被災時に想定される感染症対策
第5回東北ブロック感染症危機管理会議

2012/02/06 -

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平成23年度感染症危機管理研修会

2011/10/12 -

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2011/10/01 -

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2011/05/13 -

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2011/04/23 -

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2011/01/14 -

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「インフルエンザ感染とその対策：何がわかっていて何がわかっていないのか？」
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2010/12/09 -
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2010/11/20 -

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「インフルエンザ対策の現状と問題点」
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2010/11/19 -
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「グローバル化する感染症の脅威にどう立ち向かうべきか」
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2010/10/26 -

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2010/10/02 -

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2010/09/10 -

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「新型インフルエンザ対策の現状と課題」
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2010/09/09 -

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「新型インフルエンザ（H1N1)への対応の総括と今後の課題」
[日本国内] 第４７回大分感染症研究会

2010/08/26 -

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「新型インフルエンザへの対応：2009年の流行を振り返って見えてきた課題」
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2010/07/31 -

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「新型インフルエンザ（H1N1)：2009年の流行を振り返って見えてきた課題」
[日本国内] 第21回三河感染・免疫研究会

2010/07/10 -

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[日本国内] 第24回インフルエンザ研究者交流の会シンポジウムプログラム

2010/07/02 -

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2010/07/02 -

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2010/06/19 -

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「新型インフルエンザへの対応：2009年の総括と今後の課題」
[日本国内] 日本医科大学医学会第20回公開シンポジウム

2010/06/12 -

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「新型インフルエンザの対応とその課題」
[日本国内] 第54回倉敷胸部疾患懇話会

2010/05/26 -

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[日本国内] 仙台外来小児科懇話会

2010/03/30 -

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2010/03/30 -

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[日本国内] 岡山小児・感染免疫フォーラム

2010/03/25 -

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「新型インフルエンザA(H1N1)2009-10年の流行の統括」
[日本国内] 京都市市医会臨時総会・講演会

2010/02/28 -

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「新型インフルエンザA(H1N1)への対応の総括と課題」
[日本国内] 石川県金沢市講演会

2010/02/28 -

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「新型インフルエンザA(H1N1)への対応の総括と課題」
[日本国内] 第回元気、健康フェアin 東北

2010/02/27 -

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「新型インフルエンザの基礎と問題点」
[日本国内] 京都市市医会臨時総会

2010/02/27 -

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「新型インフルエンザA(H1N1)への対応の総括と課題」
[日本国内] 長井市西置賜郡医師会薬剤師会合同講演会

2010/02/02 -

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「新型インフルエンザA(H1N1)：これまでの日本の状況とこれからの課題」
[日本国内] 全国疫学情報データベース構築研修会

2010/01/28 -

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「新型インフルエンザA(H1N1)の疫学と公衆衛生対応」
[日本国内] いわき明星大学第17回薬学セミナー

2010/01/26 -

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「新型インフルエンザA (H1N1) の出現と課題」
[日本国内] 第19回IDATENインタラクティプ・ケースカンファレンス

2009/12/05 -

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「新型インフルエンザA/H1N1への対応：これまでの総括と今後の課題」
[日本国内] 平成２１年度阪神南圏域地域戦略推進事業・緊急講演会

2009/12/04 -

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「新型インフルエンザA/H1N1への対応：これまでの総括と今後の課題」
[日本国内] 大館北秋田医師会他学術講演会

2009/11/24 -

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「新型インフルエンザA/H1N1：地域の医療体制の課題」
[日本国内] 市民のためのサイエンス講座

2009/11/24 -

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「新型インフルエンザにどう対応すべきなのか」
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2009/11/22 -
[日本国内] 第23回日本耳鼻咽喉科学会専門医講習会

2009/11/22 -

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新興・再興感染症
[日本国内] 第49回近畿産業衛生学会

2009/11/14 -

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「インフルエンザパンデミックの基本とその対策」
[日本国内] 京都府新型インフルエンザ講演会

2009/11/10 -

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「新型インフルエンザについて」
[日本国内] 京都府市町村長防災危機管理ラボ

2009/11/10 -

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[日本国内] 「楽しむ科学教室」講演会講師

2009/11/01 -

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「新型インフルエンザの脅威と現代医学」
[日本国内] 公開講座（附属災害制御研究センター主催）

2009/10/31 -

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「新型インフルエンザの被害低減のために今何ができるのか」
[日本国内] 小山地区医師会学術講演会

2009/10/30 -

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「新型インフルエンザA/H1N1：地域の医療体制の課題」
[日本国内] 栃木県立がんセンター講演会

2009/10/30 -

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「新型インフルエンザA/H1N1：地域の医療体制の課題」
[日本国内] 大阪講演会

2009/10/29 -

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新型インフルエンザA/H1N1：現状と医療体制の課題
[日本国内] H21年度病理同窓会総会特別講演

2009/10/25 -

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「新型インフルエンザA/H1N1への対応」
[日本国内] 第63回国立病院総合医学会市民公開講座

2009/10/24 -

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「新型インフルエンザについて」
[日本国内] 新型インフルの特徴解説

2009/10/23 -
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2009/10/21 -

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新型インフルエンザA(H1N1) 総論：世界の状況とわが国の対応
[日本国内] 全国保健所長会第６６回総会会員協議

2009/10/20 -

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「新型インフルエンザA(H1N1)最新の知見」
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2009/10/19 -
[日本国内] 第4回仙台外来小児科懇話会

2009/10/19 -

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「新型インフルエンザA(H1N1）：大流行を目前ににかえ被害軽減のため何ができるのか」
[日本国内] 宮崎県医師会平成21年度県民健康セミナー

2009/10/18 -

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「われわれは新型インフルエンザにどう対応したらいいのか」
[日本国内] FETP発足10年記念シンポジウム

2009/10/16 -

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FETPに今後期待される役割？新型インフルエンザ対策等健康危機管理に関連して
[日本国内] 第11回福山市医師会インフルエンザ講演会

2009/10/15 -

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「新型インフルエンザA/H1N1への医療機関の対応」
[日本国内] 新型インフル中旬からワクチン接種

2009/10/12 -
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2009/10/09 -

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フィリピン：新型インフルエンザを見据えた重症肺炎への挑戦
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2009/10/04 -

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[日本国内] 厚木医師会学術講演会

2009/09/26 -

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「新型インフルエンザA(H1N1)に対する対応：被害軽減（Mitigation)への戦略」
[日本国内] 日本ウイルス学会後援第８回ウイルス学夏の学校・みちのくウイルス塾

2009/09/19 -

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「今回の新型インフルエンザの話：わかっていることわかっていないこと」
[日本国内] 新型インフルエンザ対策募る危機感

2009/09/18 -

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[日本国内] 新型インフルエンザ対策豪州、働き盛りが重症化

2009/09/17 -

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[日本国内] 北海道・東北ブロック保険師等研修会

2009/09/15 -

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「新型インフルエンザ対策」
[日本国内] 笹川平和財団緊急討論会

2009/09/14 -

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新型インフルエンザA(H1N1)によるパンデミックの課題
[日本国内] 亘理郡医師会公開講座講演

2009/09/05 -

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「新型インフルエンザの基礎とその対応」
[日本国内] 奈良市危機管理シンポジウム

2009/09/04 -

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「新型インフルエンザ対策の現状と課題：インフルエンザA(H1N1)にどう対応すべきか」
[日本国内] 奈良市職員対象の講演会

2009/09/04 -

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「新型インフルエンザ対策の現状と課題：インフルエンザA(H1N1)にどう対応すべきか」
[日本国内] 第48回臨床呼吸器カンファレンス

2009/09/03 -

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「インフルエンザA(H1N1)による新型インフルエンザの予想される展開と課題」
[日本国内] 新型インフルエンザ対策医師会が公開講座東北大学

2009/09/02 -

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[日本国内] 新型インフル「流行シナリオ」患者推計人口の2割

2009/08/29 -

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[日本国内] 平成２０年度庄内地域新型インフルエンザ対策検討会議

2009/08/27 -

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新型インフルエンザ対策の現状と課題
[日本国内] 医療法人医徳会真壁病院の講演会

2009/08/25 -

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新型インフルエンザA(H1N1)の現状と医療対応の課題
[日本国内] 新型インフル本格流行「想定外」なくす備えを

2009/08/22 -

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コメント
[日本国内] ＩＣＵ病床数などを調査を

2009/08/16 -
[日本国内] 阪神地区感染症懇話会

2009/07/31 -

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「インフルエンザA(H1N1)の現状と日本の対応の課題」
[日本国内] 新型インフルなぜ夏に？

2009/07/26 -
[日本国内] 平成21年度福井県自治研修所県・部次長研修

2009/07/21 -

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新型インフルエンザについて
[日本国内] 第13回日本渡航医学会学術集会

2009/07/17 -

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「新型インフルエンザの基礎知識とその対策」
[日本国内] 第10回大阪シンポジウム特別講演

2009/07/04 -

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インフルエンザA(H1N1）による新型インフルエンザの各国の状況と日本の課題
[日本国内] 長崎市医師会講演

2009/07/02 -

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「インフルエンザA(H1N1）によるパンデミックにどう対処すべきか」
[日本国内] 第45回宮城県公衆衛生学会学術総会

2009/06/25 -

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「新型インフルエンザ対策の現状と課題」
[日本国内] 新型インフルフェーズ6 人口呼吸器集中治療室を

2009/06/21 -
[日本国内] 第14回石川感染対策フォーラム特別講演

2009/06/20 -

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「A(H1N1）による新型インフルエンザの現在の状況と今後予想される展開」
[日本国内] 第17回岡山臨床呼吸器研究会

2009/06/19 -

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インフルエンザA(H1N1)による新型インフルエンザの各国の状況と日本の課題
[日本国内] 第49回日本呼吸器学会学術講演会

2009/06/13 -

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インフルエンザA(H1N1)による新型インフルエンザの各国の状況と日本の課題
[日本国内] 新型インフル終息本当か

2009/05/31 -

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コメント
[日本国内] 学校そろり再開

2009/05/25 -

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コメント
[日本国内] 空港では確認できず

2009/05/21 -

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コメント
[日本国内] 第１１期自治政策講座

2009/05/21 -

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「新型インフルエンザなどウイルス感染症への自治体の役割」
[日本国内] 笹川平和財団の講演会

2009/05/20 -

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「新型インフルエンザに関する緊急報告」
[日本国内] 東北大学新型インフルエンザ星稜地区ＦＤ

2009/05/18 -

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「豚由来A(H1N1)による新型インフルエンザの現状と今後起こり得ること」
[日本国内] 豚インフル、流行拡大の可能性割れる専門家の見方

2009/04/27 -
[日本国内] 第83回日本感染症学会総会ランチョンセミナー

2009/04/24 -

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新型インフルエンザ
[日本国内] 第83回日本感染症学会総会教育セミナー

2009/04/24 -

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WHOでの経験を含めて―感染症コントロールの国際舞台で働くために―
[日本国内] 新型インフル大流行前ワクチン 1000万人事前接種に賛否

2009/04/22 -
[日本国内] 宮城県医師会新型インフルエンザ講演会

2009/04/18 -

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「新型インフルエンザに対する医療機関の対応」
[日本国内] 八尾市医師会学術講演会

2009/04/11 -

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「新型インフルエンザ対策の基礎と課題」
[日本国内] 宇治徳洲会病院「地域連携の会」

2009/03/28 -

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新型インフルエンザの脅威を危機管理戦略
[日本国内] 名取・亘理地区ならび黒川地区地域医療対策委員会合同研修会

2009/03/26 -

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新型インフルエンザ発生時の行政・医療機関の具体的対応とその課題について
[日本国内] 新潟県議会自由民主党議員団

2009/03/25 -

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新型インフルエンザ対策について
[日本国内] 福島県保健福祉部医療看護の研修会

2009/03/23 -

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新型インフルエンザ対策の基礎と課題
[日本国内] 財団法人ヒューマンサイエンス振興財団東京

2009/03/17 -

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地域におけるパンミックへの備え
[日本国内] 北海道保健所長会

2009/03/14 -

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地域における新型インフルエンザ対策の課題
[日本国内] 財団法人ヒューマンサイエンス振興財団

2009/03/12 -

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地域におけるパンミックへの備え
[日本国内] 第9回筑後重症感染症研究会

2009/03/04 -

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新型インフルエンザ対策と課題
[日本国内] 社団法人国際厚生事業団

2009/03/02 -

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Avian and Pandemic Influenza Current Situation and Control Strategies
[日本国内] 社団法人宮城県塩釜医師会

2009/02/27 -

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新型インフルエンザ発生時の行政・医療機関等の具体的対応とその課題
[日本国内] 「寺子屋勉強会」

2009/02/26 -

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地域における新型インフルエンザ対策
[海外・国際] 基本の手洗いを指導院内感染防止で関係者に

2009/02/23 -
[日本国内] 仙台医師会

2009/02/19 -

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全ての市民が知っておくべき新型インフルエンザ対策の基礎
[日本国内] 秋田市医師会

2009/02/14 -

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型インフルエンザ対策の現状と課題
[日本国内] 新型インフルエンザ研究最前線講演会

2009/02/06 -

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新型インフルエンザの脅威とその構え
[日本国内] 多摩商工会議場

2009/01/26 -

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企業における新型インフルエンザ対策
[日本国内] 国保盛岡地区協議会

2009/01/23 -

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新型インフルエンザ対策の現状と課題
[日本国内] うるおい生活講座：ラジオ出演

2009/01/21 -

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新型インフルエンザについて
[日本国内] 5病棟先に職員発症集団感染院外からウイルスか

2009/01/19 -
[日本国内] 宮城県医師会

2009/01/17 -

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地域における新型インフルエンザ対策
[日本国内] 「発熱外来」の整備低調新型インフル初期診療

2009/01/07 -
[日本国内] 効くニュースいつ来る？新型インフルエンザ

2008/12/27 -
[日本国内] MISCO・新型インフルエンザ講演会

2008/12/19 -

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新型インフルエンザのパンデミックに企業としてどう備えたらいいのか
[日本国内] 第20回関西呼吸器感染症懇話会

2008/12/18 -

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新型インフルエンザ最近の話題
[日本国内] 東電環境エンジニアリング・新型インフルエンザ講演会

2008/12/17 -

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新型インフルエンザの発生時に予測される事態と対策について
[日本国内] 電話取材

2008/12/10 -

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新型インフルエンザの予防と対策についての電話取材
[日本国内] 石巻地区新型インフルエンザ講演会

2008/12/09 -

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新型インフルエンザ対策について
[日本国内] 新型インフル被害想定政府上回る試算相次ぎ国立感染研「首都圏、5割発症」

2008/12/01 -
[日本国内] 庄内医師集談会

2008/11/30 -

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新型インフルエンザ対策について
[日本国内] 石川中央保健福祉センター講演

2008/11/27 -

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日本の新型インフルエンザ対策の現状と課題 :今、それぞれが何をすべきかを知る
[日本国内] 名古屋新興・再興感染症講演会

2008/11/21 -

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新型インフルエンザ対策の課題
[日本国内] 福井赤十字病院

2008/11/20 -

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インフルエンザパンデミックへの備え
[日本国内] 天童市医師会

2008/11/19 -

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インフルエンザパンデミックへの備え
[日本国内] 東北大学艮陵同窓会山形県支部総会

2008/11/16 -

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インフルエンザをめぐる最近の話題
[日本国内] いわき市立総合共立病院

2008/11/08 -

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新型インフルエンザ対策の課題
[日本国内] 日本ユニシス新型インフルエンザ社内セミナー

2008/10/31 -

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新型インフルエンザの脅威
[日本国内] 第３回新型インフルエンザ疫学研修会

2008/10/30 -

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新型インフルエンザ公衆衛生対応の基本戦略
[日本国内] 佐久保健所

2008/10/29 -

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新型インフルエンザについてついて
[日本国内] 日本医師会

2008/10/25 -

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新型インフルエンザ・パンデミックー予測と対策
[日本国内] 感染症研究拠点を設置

2008/10/21 -
[日本国内] 岡崎市新型インフルエンザ対策研修会

2008/10/15 -

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新型インフルエンザ対応の医療体制について
[日本国内] 第253回保険医協会研究会

2008/10/14 -

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新型インフルエンザ対策の現状と課題
[日本国内] 宮城県立循環器・呼吸器センター

2008/10/14 -

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新型インフルエンザ対応の医療体制について
[日本国内] 東京商工会議所常議員会

2008/10/09 -

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新型インフルエンザ対策の動向について
[日本国内] 危機管理シンポジウム

2008/10/08 -

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パンデミック・フル迫りくる新型インフルエンザの脅威新型インフルエンザの基礎
[日本国内] 公研セミナー

2008/10/07 -

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新型インフルエンザと企業の危機管理
[日本国内] 第三回インターナショナルワークショップ

2008/10/05 -

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パンデミックインフルエンザについて「世界的な取り組み」
[日本国内] 奈良市新型インフルエンザ対策研修会

2008/10/01 -

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新型インフルエンザ対策の現状と課題
[日本国内] 国立感染症研究所

2008/09/18 -

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感染症危機管理について
[日本国内] 平成20年宮婦連大会

2008/09/17 -

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国境を越えるウイルス感染症
[日本国内] 内科懇話会

2008/09/12 -

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インフルエンザをめぐる最近の話題
[日本国内] 平成20年度中四国保健所長会研修会

2008/09/11 -

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新型インフルエンザの対策と保健所の役割について
[日本国内] 新型インフル対策シミュレーション現実的対応に遅れ

2008/09/10 -
[日本国内] 第２回新型インフルエンザ疫学研修会

2008/08/28 -

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新型インフルエンザ公衆衛生対応の基本戦略
[日本国内] 平成２０年度庄内地域新型インフルエンザ対策検討会議

2008/08/27 -

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新型インフルエンザ対策の現状と課題
[日本国内] 愛媛県保健所長会

2008/08/11 -

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新型インフルエンザの対策と保健所の役割につて
[日本国内] 石巻赤十字病院

2008/08/08 -

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新型インフルエンザ対策の現状と課題
[日本国内] 東京商工会議所新型インフルエンザ対策セミナー

2008/07/29 -

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新型インフルエンザの発生時に予測される事態と対策の現状について
[日本国内] 東京商工会議所

2008/07/22 -

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新型インフルエンザ発生の危険性と国の対策の現状
[日本国内] 第7回みちのくウイルス塾

2008/07/20 -

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グローバル化する新興ウイルス感染症に備えて：フィリピンにおけるウイルス感染症研究拠点づくり
[日本国内] 医療現場からパンデミックに備える新型インフル進まぬ対策

2008/07/12 -
[日本国内] 社会保険病院等検査技師長研修会

2008/07/03 -

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検査室が関わるチーム医療としての院内感染対策：鳥および新型インフルエンザの現状と対策
[日本国内] 財団法人国際保健医療交流センター

2008/06/27 -

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Avian Influenza and Pandemic Influenza
[日本国内] 新型インフル被害試算を再検討厚労省算出根拠に批判強く

2008/06/23 -
[日本国内] フィリピン・レイテ島1床に3人/酸素ボンベ共有・・・救え肺炎の子供

2008/06/21 -
[日本国内] 群馬感染症研究会

2008/06/21 -

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グローバル化する感染症の脅威〜SARS・鳥インフルエンザの教訓
[日本国内] 途上国の子供救え東北大、比で肺炎治療支援

2008/06/20 -
[日本国内] 第1回新型インフルエンザ疫学研修会

2008/06/04 -

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新型インフルエンザ公衆衛生対応の基本戦略
[日本国内] 福井県健康危機管理研修会

2008/06/04 -

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新型インフルエンザについて
[日本国内] 電話取材

2008/05/23 -

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中国四川大地震における感染症の可能性について
[日本国内] 東京都総務局総合防災部

2008/04/16 -

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新型インフルエンザ対策の現状と課題
[日本国内] アジア調査会シンポジウム

2008/04/02 -

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新型インフルエンザ対策の課題
[日本国内] 比に感染症研究拠点

2008/04/01 -
[日本国内] 阪神地区感染症懇話会講演会

2008/02/01 -

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講師演題：「感染症危機管理のあり方と心構え」当番幹事：神戸検疫所
[日本国内] 平成19年度全国保健所長会研修会

2008/01/31 -

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講演：新型インフルエンザ対策「日本の新型インフルエンザ対策の現状と課題」主催：全国保健所長会
[日本国内] 平成19年度保健所機能強化研修会

2008/01/18 -

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講師演題：「新型インフルエンザの対応について」主催：宮崎県中央保健所
[日本国内] NHKスペシャルシリーズ最強ウイルス第２夜調査報告新型インフルエンザの恐怖

2008/01/13 -

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監修
[日本国内] 市町村医療保健事業等担当課長会議

2007/12/18 -

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講師講演：「新型インフルエンザ対策の現状と課題」主催：宮城県
[海外・国際] 李俊仁記念講演会

2007/11/23 -

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Global alert- Lessons from the outbreak of SARS
[日本国内] 第6回いわき救急医療研究会

2007/11/16 -

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講演：「新型インフルエンザを含む感染症対策と救急医療」主催：持田製薬株式会社
[日本国内] 新型インフルエンザ基調講演及びパンデミック時図上訓練シンポジウム

2007/11/10 -

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講演会講師および座長主催：岩手県盛岡保健所
[日本国内] 第2回岩手県南感染制御ネットワーク本会

2007/11/09 -

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特別講演「新興ウイルス感染症にいかに備えるか」共催：岩手県南感染制御ネットワーク、ファイザー株式会社
[日本国内] 平成19年度日本医師会生涯教育講座（山形）

2007/11/06 -

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講演：「新型インフルエンザ対策の現状と課題」
[日本国内] 平成19年度日本医師会生涯教育講座（酒田）

2007/11/05 -

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講演：「新型インフルエンザ対策の現状と課題」
[日本国内] 危機管理産業展2007 スペシャル・カンファレンス危機管理セミナー

2007/10/18 -

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講演およびセッション講演：「新型インフルエンザの基礎と予測される被害」主催：（株）東京ビッグサイト危機管理産業展事務局
[日本国内] 内閣府気候変動シンポジウム第1回気候変動緩和策と適応策の最適化を考える？総合的な温暖化対策への挑戦？

2007/08/20 -

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報告「気候変動の健康影響？感染症と熱波の脅威と対処法？」
[日本国内] 「新型インフルエンザ対策について」

2007/06/30 -

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講師講演会名：「新型インフルエンザ対策について」主催：茨城県
[日本国内] 「ワクチン予防可能疾患の疫学及び対策セミナー」

2007/06/29 -

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講師セミナー名：「ワクチン予防可能疾患の疫学及び対策セミナー」主催：（財）国際保健医療交流センター
[日本国内] 新型インフルエンザ発生時対応研修会

2007/05/31 -

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研修会講師講演：「新型インフルエンザ対策とその課題」主催：岩手県盛岡保健所
[日本国内] 「鳥インフルエンザと新型インフルエンザ」現状と今後の課題について

2007/04/25 -

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講演会講師主催：仙台市眼科医会
[日本国内] 新型インフルエンザ対策及びワクチンに関する世界的動向ならびに日本の課題について

2007/03/27 -

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講師主催：ワクチンの将来を考える会
[日本国内] 「新型インフルエンザの基礎と対応」

2007/03/24 -

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講師および意見交換会助言者主催：青森県
[日本国内] 「21世紀の国際社会を生きるために」

2007/01/27 -

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講師主催：東京都立青山高校
[日本国内] 「新興感染症への対応とメディアの役割」

2007/01/24 -

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ワークショップ名：第１回宮城メディカル＆メディアワークショップ共催：東北大学感染制御・検査診断学、東北大学微生物学、東北感染制御ネットワーク
[日本国内] 「新型インフルエンザについて」

2006/12/27 -

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講師勉強会名：新型インフルエンザパンデミック時の対策に必要な行政機関と報道機関の連携に係る勉強会主催：東北厚生局
[日本国内] 「地域における新型インフルエンザ対策」気仙沼保健所

2006/12/12 -

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講師研修会名：宮城県新型インフルエンザ研修会
[日本国内] 「国際化する新興感染症の脅威とこれからの課題」

2006/12/07 -

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2006/10/30 -

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講師研修会名：宮城県新型インフルエンザ研修会
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2006/10/20 -

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2006/10/12 -

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特別講演演者講演会名：「インフルエンザワクチン学術講演会」主催：沖縄県医師会
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2006/09/20 -

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2006/08/31 -

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講師主催：東北厚生局
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2006/05/30 -

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基調講演「新型インフルエンザパンデミック時におけるWHOの対応について」主催：東北厚生局、仙台検疫所
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2006/04/04 -

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講師主催：厚生労働省健康局結核感染症課

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Type: Newspaper, magazine
[日本国内] 「いつ出現してもおかしくない新型インフルエンザ」

赤旗

2007/01/28

Type: Newspaper, magazine
[日本国内] 「新型インフルエンザ大流行に備える」

朝日新聞（全国版）

2007/01/23

Type: Newspaper, magazine
[日本国内] 「新型インフルエンザ阻止へ」

読売新聞(全国版）

2007/01/21

Type: Newspaper, magazine
[日本国内] 「時の人新型インフルと闘う」

読売新聞(宮城県版）

2006/12/22

Type: Newspaper, magazine
[日本国内] 「鳥インフルエンザと新型インフルエンザ」

医歯薬出版（株）

2006/12/15

Type: Newspaper, magazine

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原稿執筆雑誌名：月刊Medical Technology 35巻 1月号
[日本国内] 「新型インフルエンザ：日本の備えは万全か」

教育医事新聞

2006/11/25

Type: Newspaper, magazine
[日本国内] 「新型インフルエンザに備える」

NHK教育テレビ

2006/11/16

Type: TV or radio program

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番組名：「今日の健康」
[日本国内] 「新型インフルエンザへの対応」

メディカル朝日

2006/11

Type: Newspaper, magazine

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インタビューp32-35
[日本国内] 「院内感染対策で意見交換／盛岡でワークショップ」

河北新報

2006/09/23

Type: Newspaper, magazine
[日本国内] 「新型インフルエンザのお話」

東北放送（株）

2006/07/09

Type: Other

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ラジオ番組名：「家庭医学」（（株）ミノファーゲン製薬提供）
[日本国内] 新型インフルエンザの発生想定／危機管理、方策探る／仙台で研修会

河北新報

2006/05/31

Type: Newspaper, magazine
[日本国内] 新型インフルエンザ／危機管理徹底へ３０日仙台で会議

河北新報

2006/05/25

Type: Newspaper, magazine
[日本国内] 「新型インフルエンザ緊急シンポ新型視野に提言」

毎日新聞（全国版）

2006/04/29

Type: Newspaper, magazine
[日本国内] 「鳥インフルエンザ警戒を」／東北国際保健研究会、感染状況など報告

河北新報

2006/04/25

Type: Newspaper, magazine
[日本国内] 新型インフルエンザ世界的流行封じ込めへ専門家会議で議長を務めた押谷仁東北大学大学院教授

読売新聞（全国版）

2006/03

Type: Newspaper, magazine
[日本国内] 新型インフルエンザへの備え／押谷仁・東北大大学院医学系研究科教授

河北新報

2006/02/03

Type: Newspaper, magazine
[海外・国際] WHO Proposes Plan to Stop Pandemic in Its Tracks.

Sience

2006/01/20

Type: Newspaper, magazine
[海外・国際] WHO: Asia Faces Most Risk From Bird Flu

San Francisco Chronicle

2006/01/17

Type: Newspaper, magazine
[日本国内] 鳥インフルエンザ／国内まん延に警鐘／東北大でサイエンスカフェ

河北新報

2006/01/15

Type: Newspaper, magazine
[日本国内] 新型インフルエンザヒト？ヒト流行阻止

日本経済新聞

2006/01/13

Type: Newspaper, magazine
[海外・国際] WHO warns army may be needed to fight bird flu

Financial Times

2006/01/13

Type: Newspaper, magazine
[日本国内] 鳥インフルエンザ人感染７０例／発症報告に１６．７日／国際会議「新型」封じ課題山積

河北新報

2006/01/13

Type: Newspaper, magazine
[海外・国際] Quicker detection key to fighting bird flu: WHO

Channel News Asia

2006/01/12

Type: TV or radio program
[海外・国際] Bird Flu Experts Push for Early Detection, Rapid Response

Voice of America

2006/01/12

Type: Other
[海外・国際] WHO warns of huge task in fighting bird flu

Financial Times

2006/01/12

Type: Newspaper, magazine
[日本国内] 「感染症に強いアジア」構築新型インフルエンザどう対応

読売新聞

2005/02/15

Type: Newspaper, magazine

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