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Temperature-triggered microfluidic fabrication of monodisperse organic particles via LCST-mediated phase transition
Keita Tanita, Ryuju Suzuki, Hitoshi Kasai, Mao Fukuyama, Akihide Hibara, Takayuki Ishizaka
RSC Advances 16 (16) 14049-14053 2026
Publisher:
Royal Society of Chemistry (RSC)
DOI：
10.1039/d5ra08639f
eISSN：
2046-2069
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Overcoming stromal barriers in pancreatic cancer via size-engineered carrier-free nano-prodrugs
Mengheng Yang, Ryuju Suzuki, Yoshitaka Koseki, Shuto Kodera, Ken Saijo, Hisato Kawakami, Keita Tanita, Sanjay Kumar, Kouki Oka, Hitoshi Kasai
RSC Pharmaceutics 2026
Publisher:
Royal Society of Chemistry (RSC)
DOI：
10.1039/d5pm00364d
eISSN：
2976-8713
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Newly acylated SN-38 homodimers: carrier-free nano-prodrugs for chemotherapy
Peer-reviewed
Sanjay Kumar, Yoshitaka Koseki, Keita Tanita, Hitoshi Kasai
Mendeleev Communications 35 (3) 278-281 2025/03
Publisher:
OOO Zhurnal "Mendeleevskie Soobshcheniya"
DOI：
10.71267/mencom.7664
ISSN：
0959-9436
eISSN：
1364-551X
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SN-38-indoximod conjugate: carrier free nano-prodrug for cancer therapy
Sanjay Kumar, Yoshitaka Koseki, Keita Tanita, Aki Shibata, Asuka Mizutani, Hitoshi Kasai
THERAPEUTIC DELIVERY 2025/02/02
DOI：
10.1080/20415990.2025.2458449
ISSN：
2041-5990
eISSN：
2041-6008
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SN-38-cholesterol NPs-loaded PDA NPs/agarose & pluronic F-127 hydrogel system for controlled chemo-phototherapy in tumor-localized treatment
Zhixiang Liu, Yoshitaka Koseki, Mengheng Yang, Keita Tanita, Hitoshi Kasai
Journal of Materials Chemistry B 13 (34) 10584-10599 2025
Publisher:
Royal Society of Chemistry (RSC)
DOI：
10.1039/d5tb00994d
ISSN：
2050-750X
eISSN：
2050-7518
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Carrier-free nano-prodrugs for minimally invasive cancer therapy
Keita Tanita, Yoshitaka Koseki, Sanjay Kumar, Farsai Taemaitree, Asuka Mizutani, Hirotaka Nakatsuji, Ryuju Suzuki, Anh Thi Ngoc Dao, Fumiyoshi Fujishima, Hiroshi Tada, Takanori Ishida, Ken Saijo, Chikashi Ishioka, Hitoshi Kasai
NANOSCALE 16 (32) 15256-15264 2024/08/15
DOI：
10.1039/d4nr01763c
ISSN：
2040-3364
eISSN：
2040-3372
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Fabrication of carrier-free heterodimeric nano-prodrugs with podophyllotoxin and SN-38 for a co-delivery system
Yoshitaka Koseki, Keita Tanita, Motofumi Nakamura, Aki Shibata, Kiyotaka Maruoka, Takaaki Kamishima, Hitoshi Kasai
MOLECULAR CRYSTALS AND LIQUID CRYSTALS 768 (12) 481-487 2024/08/12
DOI：
10.1080/15421406.2024.2353966
ISSN：
1542-1406
eISSN：
1563-5287
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Anticancer nano-prodrugs with drug release triggered by intracellular dissolution and hydrogen peroxide response
Aki Shibata, Yoshitaka Koseki, Keita Tanita, Showa Kitajima, Kouki Oka, Kiyotaka Maruoka, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai
CHEMICAL COMMUNICATIONS 60 (50) 6427-6430 2024/06/18
DOI：
10.1039/d4cc02252a
ISSN：
1359-7345
eISSN：
1364-548X
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Fabrication of anti-inflammatory nano eye-drops composed of dexamethasone prodrugs
Keita Tanita, Mai Iijima, Yoshitaka Koseki, Kota Sato, Toru Nakazawa, Hitoshi Kasai
MOLECULAR CRYSTALS AND LIQUID CRYSTALS 762 (1) 81-87 2023/09/02
DOI：
10.1080/15421406.2023.2180212
ISSN：
1542-1406
eISSN：
1563-5287
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Ir-Catalyzed Cascade Reaction Promotes the Formation of Geometrically Selective Enones from Bis-allyl Alcohols
Takaaki Kamishima, Yoshitaka Koseki, Hirotaka Nakatsuji, Sanjay Kumar, Keita Tanita, Hitoshi Kasai
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2022 (43) 2022/11/18
DOI：
10.1002/ejoc.202201002
ISSN：
1434-193X
eISSN：
1099-0690
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Development of camptothecin nano-prodrugs based on trimethyl lock groups toward selective drug release in cancer cells
Aki Shibata, Yoshitaka Koseki, Keita Tanita, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai
TETRAHEDRON LETTERS 103 2022/08/03
DOI：
10.1016/j.tetlet.2022.153989
ISSN：
0040-4039
eISSN：
1873-3581
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Fabrication of Hinokitiol-modified podophyllotoxin nano-prodrugs having a high drug loading capacity
Keita Tanita, Yoshitaka Koseki, Kazue Shimizu, Hirohito Umezawa, Hitoshi Kasai
MOLECULAR CRYSTALS AND LIQUID CRYSTALS 706 (1) 79-85 2020/07/23
DOI：
10.1080/15421406.2020.1743441
ISSN：
1542-1406
eISSN：
1563-5287
-
Tropone Skeleton Enhances the Dispersion Stability of Nano-prodrugs
Keita Tanita, Yoshitaka Koseki, Takaaki Kamishima, Hitoshi Kasai
CHEMISTRY LETTERS 49 (3) 222-224 2020/03
DOI：
10.1246/cl.190876
ISSN：
0366-7022
eISSN：
1348-0715
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Influence of Hydrolysis Susceptibility and Hydrophobicity of SN-38 Nano-Prodrugs on Their Anticancer Activity
Yoshitaka Koseki, Yoshikazu Ikuta, Liman Cong, Mayumi Takano-Kasuya, Hiroshi Tada, Mika Watanabe, Kohsuke Gonda, Takanori Ishida, Noriaki Ohuchi, Keita Tanita, Farsai Taemaitree, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 92 (8) 1305-1313 2019/08
DOI：
10.1246/bcsj.20190088
ISSN：
0009-2673
eISSN：
1348-0634
https://orcid.org/0009-0007-9906-6374