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Shin Yoshizawa

Section

Graduate School of Engineering

Job title

Professor

Degree

博士（工学）（東京大学）
修士（工学）（東京大学）

researchmap

https://researchmap.jp/read0134571

J-GLOBAL ID

200901019935946027

Research History 7

2021/10 - Present

Tohoku University　Graduate School of Engineering, Department of Communications Engineering　Professor
2013/05 - 2021/09

Tohoku University　Graduate School of Engineering, Department of Communications Engineering
2012/04 - 2013/04

Tohoku University　Graduate School of Engineering, Department of Communications Engineering
2007/05 - 2012/03

Tohoku University　Graduate School of Engineering, Department of Electrical and Communication Engineering
2007/04 - 2007/04

理化学研究所　日本学術振興会特別研究員（PD）
2006/04 - 2007/03

東京大学大学院工学系研究科　日本学術振興会特別研究員（PD）
2002/04 - 2003/03

日本電気株式会社

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Education 5

The University of Tokyo　Graduate School, Division of Engineering

2003/10 - 2006/03
The University of Tokyo　The Graduate School of Engineering

2003/04 - 2003/09
The University of Tokyo　The Graduate School of Engineering　Department of Mechanical Engineering

2000/04 - 2002/03
The University of Tokyo　Faculty of Engineering　産業機械工学科

1998/04 - 2000/03
The University of Tokyo　College of Arts and Sciences

1996/04 - 1998/03

Professional Memberships 5

ACOUSTICAL SOCIETY OF JAPAN
IEEE
電子情報通信学会
The Japan Society of Ultrasonics in Medicine
The Japan Society of Mechanical Engineers

Research Interests 4

ultrasound treatment
HIFU
cavitaiton
microbubble

Research Areas 3

Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Fluid engineering /
Life sciences / Biomaterials /
Life sciences / Biomedical engineering /

Awards 7

大学発ベンチャー表彰経済産業大臣賞

2024/08
Best paper award

2023/05　Displacement detection with sub-pixel accuracy and high spatial resolution using deep learning
Symposium on Ultrasonic Electronics Best Paper Award

2021/10　Comparison between thermal strain and acoustic radiation force imaging methods for estimation of heat source distribution of high-intensity focused ultrasound
Symposium on Ultrasonic Electronics Best Paper Award

2018/10　Singular value decomposition of received ultrasound signal to separate tissue, blood flow, and cavitation signals
Symposium on Ultrasonic Electronics Best Paper Award

2016/11　Quantitative measurement of ultrasound pressure field by optical phase contrast method and acoustic holography
日本超音波医学会第15回奨励賞

2014/05/10　一般社団法人日本超音波医学会
2006年度日本機械学会賞（論文賞）

2007/04/06　日本機械学会

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Papers 102

Improvement of contrast ratio between cavitation bubbles and tissue by frequency filtering in triplet pulse ultrasound imaging

Shota Kuji, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　63　(4)　2024/04/01

DOI： 10.35848/1347-4065/ad2d06 　

ISSN： 0021-4922

eISSN： 1347-4065
Expansion of the cavitation region using ultrasound focus scanning in the direction of ultrasound propagation for an efficient method of histotripsy

Kazuki Takahashi, Shin Yoshizawa

Japanese Journal of Applied Physics　63　(4)　2024/04/01

DOI： 10.35848/1347-4065/ad2d78 　

ISSN： 0021-4922

eISSN： 1347-4065
Effect of intended shift in propagation direction of cavitation generation position on coagulation position in bubble-enhanced ultrasonic heating

Sota Kannoto, Shin Yoshizawa

Japanese Journal of Applied Physics　63　(3)　2024/03/01

DOI： 10.35848/1347-4065/ad2916 　

ISSN： 0021-4922

eISSN： 1347-4065
Basic study on a filtering method for selectively extracting cavitation bubble region in ultrasound imaging by triplet pulse sequence

Shota Kuji, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　62　(SJ)　2023/07/01

DOI： 10.35848/1347-4065/acbe03 　

ISSN： 0021-4922

eISSN： 1347-4065
Development of efficient method of generating reactive oxygen species by expanding cavitation region using ultrasound focus scanning in the direction of ultrasound propagation

Shotaro Miyake, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　62　(SJ)　2023/07/01

DOI： 10.35848/1347-4065/accaf0 　

ISSN： 0021-4922

eISSN： 1347-4065
A study on correction method of total acoustic power in presence of shielding in focused ultrasound treatment using acoustic radiation force imaging

Erika Numahata, Shin Yoshizawa, Shin Ichiro Umemura, Takuro Ishii, Yoshifumi Saijo

Japanese Journal of Applied Physics　62　2023/07/01
Publisher: IOP Publishing
DOI： 10.35848/1347-4065/acc595 　

ISSN： 0021-4922

eISSN： 1347-4065
Quantitative analysis of heat-source estimation of high-intensity focused ultrasound using thermal strain imaging

Nozomi Obara, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　61　(SG)　2022/07/01

DOI： 10.35848/1347-4065/ac5d15 　

ISSN： 0021-4922

eISSN： 1347-4065
光音響・高周波超音波東北大学における光音響/高周波超音波イメージング

西條芳文, 新楯諒, 鈴木陸, 石井琢郎, 荒川元孝, 梅村晋一郎, 吉澤晋, 長岡亮, 小林和人, 根本隆治

超音波医学　49　(Suppl.)　S522-S522　2022/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
Displacement detection with sub-pixel accuracy and high spatial resolution using deep learning

Mariko Yamamoto, Shin Yoshizawa

Journal of Medical Ultrasonics　49　(1)　3-15　2022/01

DOI： 10.1007/s10396-021-01162-7 　

ISSN： 1346-4523

eISSN： 1613-2254
Effect of difference in shear modulus of biological tissue on heat source distribution of high-intensity focused ultrasound estimated by acoustic radiation force imaging

Hiroki Yabata, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　60　2021/07

DOI： 10.35848/1347-4065/abf4a7 　

ISSN： 0021-4922

eISSN： 1347-4065
Effects from correction of speed of sound in transmit and receive beamforming using focus beam

Ryo Nagaoka, Shin Yoshizawa, Shin Ichiro Umemura, Hideyuki Hasegawa

Japanese Journal of Applied Physics　60　(SD)　SDDE19-SDDE19　2021/07/01
Publisher: IOP Publishing
DOI： 10.35848/1347-4065/abf55b 　

ISSN： 0021-4922

eISSN： 1347-4065
Investigation of feasibility of noise suppression method for cavitation-enhanced high-intensity focused ultrasound treatment

Ryo Takagi, Yoshihiko Koseki, Shin Yoshizawa, Shin ichiro Umemura

Ultrasonics　114　2021/07

DOI： 10.1016/j.ultras.2021.106394 　

ISSN： 0041-624X
Effect of focal spot scanning method in agarose gel and chicken breast on heating efficiency in cavitation-enhanced ultrasonic heating

Kohei Ueda, Sayaka Ito, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　60　2021/07

DOI： 10.35848/1347-4065/abf2a8 　

ISSN： 0021-4922

eISSN： 1347-4065
Comparison between thermal strain and acoustic radiation force imaging methods for estimation of heat source distribution of high-intensity focused ultrasound

Nozomi Obara, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　60　(SD)　2021/07

DOI： 10.35848/1347-4065/abef0a 　

ISSN： 0021-4922

eISSN： 1347-4065
Effect of ultrasonic intensity and intervals of ultrasonic exposure on efficiency of sonochemiluminescence in gel phantom for sonodynamic therapy

Kenki Tsukahara, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　60　2021/07

DOI： 10.35848/1347-4065/abf4a4 　

ISSN： 0021-4922

eISSN： 1347-4065
Analysis of tissue displacement induced by high-intensity focused ultrasound exposure for coagulation monitoring

Mariko Yamamoto, Shin Yoshizawa

Japanese Journal of Applied Physics　60　(4)　2021/04

DOI： 10.35848/1347-4065/abeb4c 　

ISSN： 0021-4922

eISSN： 1347-4065
Effects of intermittent duration of ultrasound exposure on temperature rise and behavior of cavitation bubbles in bubble-enhanced ultrasonic heating

Sayaka Ito, Shin Ichiro Umernura, Shin Yoshizawa

Acoustical Science and Technology　41　(6)　913-916　2020/11/01

DOI： 10.1250/ast.41.913 　

ISSN： 1346-3969

eISSN： 1347-5177
Effect of split-aperture transmission on cavitation bubbles and ultrasonic heating outside focal region in high-intensity focused ultrasound exposure

Yui Tanaka, Shin Ichiro Urnernura, Shin Yoshizawa

Acoustical Science and Technology　41　(6)　909-912　2020/11/01

DOI： 10.1250/ast.41.909 　

ISSN： 1346-3969

eISSN： 1347-5177
Experimental investigation of effect of ultrasonic duty cycle on generation of reactive oxygen species for highly efficient sonodynamic treatment Peer-reviewed

Kenki Tsukahara, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　59　SKKE08　2020/07

DOI： 10.35848/1347-4065/ab82a5 　

ISSN： 0021-4922

eISSN： 1347-4065
Ultrasound imaging of cavitation using triplet pulse sequence in bubble-enhanced ultrasonic heating Peer-reviewed

Ikumi Shiozaki, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　59　SKKE05　2020/07

DOI： 10.35848/1347-4065/ab7fe5 　

ISSN： 0021-4922

eISSN： 1347-4065
Effect of shear wave propagation on estimation of heating distribution by high-intensity focused ultrasound using acoustic radiation force imaging Peer-reviewed

Hiroki Yabata, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　59　SKKE19　2020/07

DOI： 10.35848/1347-4065/ab8be4 　

ISSN： 0021-4922

eISSN： 1347-4065
Ultrasound Sub-pixel Motion-tracking Method with Out-of-plane Motion Detection for Precise Vascular Imaging Peer-reviewed

Hideki Yoshikawa, Taku Yamamoto, Tomohiko Tanaka, Ken ichi Kawabata, Shin Yoshizawa, Shin ichiro Umemura

Ultrasound in Medicine and Biology　46　(3)　782-795　2020/03

DOI： 10.1016/j.ultrasmedbio.2019.11.005 　

ISSN： 0301-5629

eISSN： 1879-291X
Development of a High-intensity Focused Ultrasound Exposure Device for Reducing Skin Burn Risk

Shogo NISHII, Kohei SEO, Aleksander Tatsuya IZDEBSKI, Miki KUSHIMA, Ryo TAKAGI, Shin YOSHIZAWA, Shin-ichiro UMEMURA, Kiyotake ICHIZUKA, Akihiko SEKIZAWA

The Showa University Journal of Medical Sciences　32　(1)　1-9　2020
Publisher: The Showa University Society
DOI： 10.15369/sujms.32.1 　

ISSN： 0915-6380

eISSN： 2185-0968
Treatment of twin-reversed arterial perfusion sequence using high-intensity focused ultrasound

K. Seo, K. Ichizuka, T. Okai, S. Dohi, M. Nakamura, J. Hasegawa, R. Matsuoka, S. Yoshizawa, S. I. Umemura, M. Nagatsuka, A. Sekizawa

Ultrasound in Obstetrics and Gynecology　54　128-134　2019/07/01

DOI： 10.1002/uog.20101 　

ISSN： 0960-7692
Sonodynamic Therapy: Advances and Challenges in Clinical Translation

Maxime Lafond, Shin Yoshizawa, Shin ichiro Umemura

Journal of Ultrasound in Medicine　38　567-580　2019/03/01

DOI： 10.1002/jum.14733 　

ISSN： 0278-4297
Blood flow imaging using singular value decomposition filter during high-intensity focused ultrasound exposure Peer-reviewed

Hayato Ikeda, Shin Yoshizawa, Moe Maeda, Shin Ichiro Umemura, Yoshifumi Saijo

Japanese Journal of Applied Physics　58　SGGE15　2019

DOI： 10.7567/1347-4065/ab1a2e 　

ISSN： 0021-4922
Effect of inter-focal distance and interval time in focus scanning of high-intensity focused ultrasound on efficiency of reactive oxygen generation Peer-reviewed

Daisaku Mashiko, Shin Ichiro Umemura, Shin Yoshizawa

Japanese Journal of Applied Physics　58　SGGE04　2019

DOI： 10.7567/1347-4065/ab0df6 　

ISSN： 0021-4922
Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer. International-journal

Yuki Horise, Masanori Maeda, Yoshiyuki Konishi, Jun Okamoto, Soko Ikuta, Yoshiharu Okamoto, Hiroshi Ishii, Shin Yoshizawa, Shinichiro Umemura, Tsuyoshi Ueyama, Satoshi Tamano, Atsushi Sofuni, Kazuhisa Takemae, Ken Masamune, Hiroshi Iseki, Nobuhiro Nishiyama, Kazunori Kataoka, Yoshihiro Muragaki

Frontiers in pharmacology　10　545-545　2019

DOI： 10.3389/fphar.2019.00545 　
Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles Peer-reviewed

Maxime Lafond, Akiko Watanabe, Shin Yoshizawa, Shin-Ichiro Umemura, Katsuro Tachibana

Scientific Reports　8　(1)　7472　2018/12/01

DOI： 10.1038/s41598-018-25913-8 　

ISSN： 2045-2322
Singular value decomposition of received ultrasound signal to separate tissue, blood flow, and cavitation signals Peer-reviewed

Ikeda Hayato, Nagaoka Ryo, Lafond Maxime, Yoshizawa Shin, Iwasaki Ryosuke, Maeda Moe, Umemura Shin-ichiro, Saijo Yoshifumi

JAPANESE JOURNAL OF APPLIED PHYSICS　57　(7)　07LF04　2018/07

DOI： 10.7567/JJAP.57.07LF04 　

ISSN： 0021-4922
Basic study of improvement of axial resolution and suppression of time side lobe by phase-corrected Wiener filtering in photoacoustic tomography Peer-reviewed

Nagaoka Ryo, Yoshizawa Shin, Umemura Shin-ichiro, Saijo Yoshifumi

JAPANESE JOURNAL OF APPLIED PHYSICS　57　(7)　07LD11　2018/07

DOI： 10.7567/JJAP.57.07LD11 　

ISSN： 0021-4922
Selective detection of cavitation bubbles by triplet pulse sequence in high-intensity focused ultrasound treatment Peer-reviewed

Iwasaki Ryosuke, Nagaoka Ryo, Yoshizawa Shin, Umemura Shin-ichiro

JAPANESE JOURNAL OF APPLIED PHYSICS　57　(7)　07LF12　2018/07

DOI： 10.7567/JJAP.57.07LF12 　

ISSN： 0021-4922
Quantitative measurement of ultrasonic pressure field using combination of optical phase contrast and nonlinear acoustic holography methods Peer-reviewed

Nakamura Takuya, Iwasaki Ryosuke, Yoshizawa Shin, Umemura Shin-ichiro

JAPANESE JOURNAL OF APPLIED PHYSICS　57　(7)　07LB13　2018/07

DOI： 10.7567/JJAP.57.07LB13 　

ISSN： 0021-4922
Estimation of sonodynamic treatment region with sonochemiluminescence in gel phantom Peer-reviewed

Mashiko Daisaku, Nishitaka Shinya, Iwasaki Ryosuke, Lafond Maxime, Yoshizawa Shin, Umemura Shin-ichiro

JAPANESE JOURNAL OF APPLIED PHYSICS　57　(7)　07LF13　2018/07

DOI： 10.7567/JJAP.57.07LF13 　

ISSN： 0021-4922
Effect of annular focusing of ultrasound on rate of stone erosion using cavitation bubbles Peer-reviewed

Yura Toshiya, Lafond Maxime, Yoshizawa Shin, Umemura Shin-ichiro

JAPANESE JOURNAL OF APPLIED PHYSICS　57　(7)　07LB18　2018/07

DOI： 10.7567/JJAP.57.07LB18 　

ISSN： 0021-4922
Effect of scanning the focus on generating cavitation bubbles and reactive oxygen species by using trigger high-intensity focused ultrasound sequence Peer-reviewed

Nishitaka Shinya, Mashiko Daisaku, Yoshizawa Shin, Umemura Shin-ichiro

JAPANESE JOURNAL OF APPLIED PHYSICS　57　(7)　07LF25　2018/07

DOI： 10.7567/JJAP.57.07LF25 　

ISSN： 0021-4922
Visualization of murine lymph vessels using photoacoustic imaging with contrast agents Peer-reviewed

Ryo Nagaoka, Takuya Tabata, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo

Photoacoustics　9　39-48　2018/03/01

DOI： 10.1016/j.pacs.2018.01.001 　

ISSN： 2213-5979
SONODYNAMIC THERAPY BASED ON COMBINED USE OF LOW DOSE ADMINISTRATION OF EPIRUBICIN-INCORPORATING DRUG DELIVERY SYSTEM AND FOCUSED ULTRASOUND Peer-reviewed

Masanori Maeda, Yoshihiro Muragaki, Jun Okamoto, Shin Yoshizawa, Nobutaka Abe, Hidekazu Nakamoto, Hiroshi Ishii, Kenichi Kawabata, Shinichiro Umemura, Nobuhiro Nishiyama, Kazunori Kataoka, Hiroshi Iseki

ULTRASOUND IN MEDICINE AND BIOLOGY　43　(10)　2295-2301　2017/10

DOI： 10.1016/j.ultrasmedbio.2017.06.003 　

ISSN： 0301-5629

eISSN： 1879-291X
Development of Real-Time 3-D Photoacoustic Imaging System Employing Spherically Curved Array Transducer Peer-reviewed

Ryo Nagaoka, Takuya Tabata, Ryo Takagi, Shin Yoshizawa, Shin-Ichiro Umemura, Yoshifumi Saijo

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL　64　(8)　1223-1233　2017/08

DOI： 10.1109/TUFFC.2017.2718030 　

ISSN： 0885-3010

eISSN： 1525-8955
Simulation of optical propagation based on wave optics for phase retrieval in shadowgraph of ultrasonic field Peer-reviewed

Hiroki Hanayama, Takuya Nakamura, Ryo Takagi, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　56　(7)　07JC13　2017/07

DOI： 10.7567/JJAP.56.07JC13 　

ISSN： 0021-4922

eISSN： 1347-4065
Prediction of thermal coagulation from the instantaneous strain distribution induced by high-intensity focused ultrasound Peer-reviewed

Ryosuke Iwasaki, Ryo Takagi, Kentaro Tomiyasu, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　56　(7)　07JF23　2017/07

DOI： 10.7567/JJAP.56.07JF23 　

ISSN： 0021-4922

eISSN： 1347-4065
Simultaneous observation of cavitation bubbles generated in biological tissue by high-speed optical and acoustic imaging methods Peer-reviewed

Kai Suzuki, Ryosuke Iwasaki, Ryo Takagi, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　56　(7)　07JF27　2017/07

DOI： 10.7567/JJAP.56.07JF27 　

ISSN： 0021-4922

eISSN： 1347-4065
Basic study on ultrasonic monitoring using 1.5-dimensional ultrasound phased array for ultrasound-guided high-intensity focused ultrasound treatment Peer-reviewed

Ryo Takagi, Ryosuke Iwasaki, Kentaro Tomiyasu, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　56　(7)　07JF22　2017/07

DOI： 10.7567/JJAP.56.07JF22 　

ISSN： 0021-4922

eISSN： 1347-4065
Multifunctional pulse generator for high-intensity focused ultrasound system Peer-reviewed

Satoshi Tamano, Shin Yoshizawa, Shin-Ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　56　(7)　07JF21　2017/07

DOI： 10.7567/JJAP.56.07JF21 　

ISSN： 0021-4922

eISSN： 1347-4065
Control of treatment size in cavitation-enhanced high-intensity focused ultrasound using radio-frequency echo signals Peer-reviewed

Kentaro Tomiyasu, Ryo Takagi, Ryosuke Iwasaki, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　56　(7)　07JF28　2017/07

DOI： 10.7567/JJAP.56.07JF28 　

ISSN： 0021-4922

eISSN： 1347-4065
Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation Peer-reviewed

Shin Yoshizawa, Ryo Takagi, Shin-ichiro Umemura

APPLIED SCIENCES-BASEL　7　(3)　288　2017/03

DOI： 10.3390/app7030288 　

ISSN： 2076-3417
Evaluation of Second-generation HIFU Systems: Less-invasive Fetal Therapy for TRAP Sequence Peer-reviewed

SEO Kohei, YOSHIZAWA Shin, UMEMURA Shin-ichiro, SEKIZAWA Akihiko, ICHIZUKA Kiyotake, OKAI Takashi, NAKAMURA Masamitsu, HASEGAWA Jun-ichi, MATSUOKA Ryu, KITADAI Yuzo, SUMIE Masahiro, TSUKIMORI Kiyomi

The Showa University Journal of Medical Sciences　29　(3)　241-251　2017
Publisher: Showa University Society
DOI： 10.15369/sujms.29.241 　

ISSN： 0915-6380

More details Close

In this report, the second-generation high-intensity focused ultrasound （HIFU） systems were clinically evaluated for human fetal therapy in two cases of twin reversed arterial perfusion sequence. The HIFU systems comprised an improved lead zirconate-titanate transducer with an imaging phase array sector probe, a Sonachill cooling system, and three phases of HIFU exposure: a trigger pulse, a continuous heating wave, and an idle period to obtain images with the imaging probe set on the transducer. To evaluate skin surface temperature, a thermal camera was used. To evaluate vessel occlusions, blood flow was measured at fixed timings after exposures. Target vessel occlusion was achieved with HIFU in only one of the cases, but recanalization occurred the following day. Both cases were finally treated with radiofrequency ablation and one infant was successfully delivered without any complications. This case highlighted three advantages with the change to second-generation HIFU systems in human fetal therapy: the simplicity of maneuvers by reduced range of motion disturbance; the ability to observe in real time during the exposure; and a decrease in total ultrasonic output. Treatment interruption due to burns or complaints of heat sensation represented an obstruction to treatment completion. This remains an issue to be addressed in the future.
Feasibility of real-time treatment feedback using novel filter for eliminating therapeutic ultrasound noise with high-speed ultrasonic imaging in ultrasound-guided high-intensity focused ultrasound treatment Peer-reviewed

Ryo Takagi, Hayato Jimbo, Ryosuke Iwasaki, Kentaro Tomiyasu, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KC10　2016/07

DOI： 10.7567/JJAP.55.07KC10 　

ISSN： 0021-4922

eISSN： 1347-4065
Improvement of high-voltage staircase drive circuit waveform for high-intensity therapeutic ultrasound Peer-reviewed

Satoshi Tamano, Hayato Jimbo, Takashi Azuma, Shin Yoshizawa, Keisuke Fujiwara, Kazunori Itani, Shin-Ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KF17　2016/07

DOI： 10.7567/JJAP.55.07KF17 　

ISSN： 0021-4922

eISSN： 1347-4065
Study on heavy matching layer transducer towards producing second harmonics Peer-reviewed

Zulfadhli Zaini, Masamizu Osuga, Hayato Jimbo, Jun Yasuda, Ryo Takagi, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KF15　2016/07

DOI： 10.7567/JJAP.55.07KF15 　

ISSN： 0021-4922

eISSN： 1347-4065
Monitoring of high-intensity focused ultrasound treatment by shear wave elastography induced by two-dimensional-array therapeutic transducer Peer-reviewed

Ryosuke Iwasaki, Ryo Takagi, Ryo Nagaoka, Hayato Jimbo, Shin Yoshizawa, Yoshifumi Saijo, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KF05　2016/07

DOI： 10.7567/JJAP.55.07KF05 　

ISSN： 0021-4922

eISSN： 1347-4065
Quantitative measurement of ultrasound pressure field by optical phase contrast method and acoustic holography Peer-reviewed

Seiji Oyama, Jun Yasuda, Hiroki Hanayama, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KB09　2016/07

DOI： 10.7567/JJAP.55.07KB09 　

ISSN： 0021-4922

eISSN： 1347-4065
Acceleration of lithotripsy using cavitation bubbles induced by second-harmonic superimposition Peer-reviewed

Masamizu Osuga, Jun Yasuda, Hayato Jimbo, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KF18　2016/07

DOI： 10.7567/JJAP.55.07KF18 　

ISSN： 0021-4922

eISSN： 1347-4065
Study on cavitation behavior during high-intensity focused ultrasound exposure by using optical and ultrasonic imaging Peer-reviewed

Kei Taguchi, Ryo Takagi, Jun Yasuda, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KF22　2016/07

DOI： 10.7567/JJAP.55.07KF22 　

ISSN： 0021-4922

eISSN： 1347-4065
Advantage of annular focus generation by sector-vortex array in cavitation-enhanced high-intensity focused ultrasound treatment Peer-reviewed

Hayato Jimbo, Ryo Takagi, Kei Taguchi, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KF19　2016/07

DOI： 10.7567/JJAP.55.07KF19 　

ISSN： 0021-4922

eISSN： 1347-4065
Efficient generation of cavitation bubbles and reactive oxygen species using triggered high-intensity focused ultrasound sequence for sonodynamic treatment Peer-reviewed

Jun Yasuda, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KF24　2016/07

DOI： 10.7567/JJAP.55.07KF24 　

ISSN： 0021-4922

eISSN： 1347-4065
Detection of tissue coagulation by decorrelation of ultrasonic echo signals in cavitation-enhanced high-intensity focused ultrasound treatment Peer-reviewed

Shin Yoshizawa, Keiko Matsuura, Ryo Takagi, Mariko Yamamoto, Shin-Ichiro Umemura

Journal of Therapeutic Ultrasound　4　(1)　15　2016
Publisher: BioMed Central Ltd.
DOI： 10.1186/s40349-016-0060-0 　

ISSN： 2050-5736
Effect of controlled offset of focal position in cavitation-enhanced high-intensity focused ultrasound treatment Peer-reviewed

Kota Goto, Ryo Takagi, Takuya Miyashita, Hayato Jimbo, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　54　(7)　07HF12　2015/07

DOI： 10.7567/JJAP.54.07HF12 　

ISSN： 0021-4922

eISSN： 1347-4065
Basic study of intrinsic elastography: Relationship between tissue stiffness and propagation velocity of deformation induced by pulsatile flow Peer-reviewed

Ryo Nagaoka, Ryosuke Iwasaki, Mototaka Arakawa, Kazuto Kobayashi, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo

JAPANESE JOURNAL OF APPLIED PHYSICS　54　(7)　07HF08　2015/07

DOI： 10.7567/JJAP.54.07HF08 　

ISSN： 0021-4922

eISSN： 1347-4065
Quantitative assessment of reactive oxygen sonochemically generated by cavitation bubbles Peer-reviewed

Jun Yasuda, Takuya Miyashita, Kei Taguchi, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　54　(7)　07HF21　2015/07

DOI： 10.7567/JJAP.54.07HF21 　

ISSN： 0021-4922

eISSN： 1347-4065
Effects of cavitation-enhanced heating in high-intensity focused ultrasound treatment on shear wave imaging Peer-reviewed

Ryosuke Iwasaki, Ryo Nagaoka, Ryo Takagi, Kota Goto, Shin Yoshizawa, Yoshifumi Saijo, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　54　(7)　07HF11　2015/07

DOI： 10.7567/JJAP.54.07HF11 　

ISSN： 0021-4922

eISSN： 1347-4065
Quantitative measurement of high intensity focused ultrasound pressure field by optical phase contrast method applying non-continuous phase unwrapping algorithm Peer-reviewed

Mohd Syahid, Seiji Oyama, Jun Yasuda, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　54　(7)　07HC09　2015/07

DOI： 10.7567/JJAP.54.07HC09 　

ISSN： 0021-4922

eISSN： 1347-4065
Elimination of therapeutic ultrasound noise from pre-beamformed RF data in ultrasound imaging for ultrasound-guided high-intensity focused ultrasound treatment Peer-reviewed

Ryo Takagi, Kota Goto, Hayato Jimbo, Keiko Matsuura, Ryosuke Iwasaki, Shin-ichiro Umemura, Shin Yoshizawa

JAPANESE JOURNAL OF APPLIED PHYSICS　54　(7)　07HD10　2015/07

DOI： 10.7567/JJAP.54.07HD10 　

ISSN： 0021-4922

eISSN： 1347-4065
Measurement of regional pulse-wave velocity using spatial compound imaging of the common carotid artery in vivo Peer-reviewed

Ryo Nagaoka, Genta Masuno, Kazuto Kobayashi, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo

ULTRASONICS　55　(1)　92-103　2015/01

DOI： 10.1016/j.ultras.2014.07.018 　

ISSN： 0041-624X

eISSN： 1874-9968
Monitoring of high-intensity focused ultrasound lesion formation using decorrelation between high-speed ultrasonic images by parallel beamforming Peer-reviewed

Shoya Sasaki, Ryo Takagi, Keiko Matsuura, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　53　(7)　07KF10　2014/07

DOI： 10.7567/JJAP.53.07KF10 　

ISSN： 0021-4922

eISSN： 1347-4065
Quantitative measurement of focused ultrasound pressure field by background-subtracted shadowgraph using holographic diffuser as screen Peer-reviewed

Ryo Miyasaka, Jun Yasuda, Mohd Syahid, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　53　(7)　07KF24　2014/07

DOI： 10.7567/JJAP.53.07KF24 　

ISSN： 0021-4922

eISSN： 1347-4065
Effects of rose bengal on cavitation generation in gel phantom investigated using high-speed camera Peer-reviewed

Jun Yasuda, Takuya Miyashita, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　53　(7)　07KF20　2014/07

DOI： 10.7567/JJAP.53.07KF20 　

ISSN： 0021-4922

eISSN： 1347-4065
Highly efficient cavitation-enhanced heating with dual-frequency ultrasound exposure in high-intensity focused ultrasound treatment Peer-reviewed

Hiroshi Sasaki, Jun Yasuda, Ryo Takagi, Takuya Miyashita, Kota Goto, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　53　(7)　07KF11　2014/07

DOI： 10.7567/JJAP.53.07KF11 　

ISSN： 0021-4922

eISSN： 1347-4065
High-speed observation of bubble cloud generation near a rigid wall by second-harmonic superimposed ultrasound Peer-reviewed

Shin Yoshizawa, Jun Yasuda, Shin-ichiro Umemura

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA　134　(2)　1515-1520　2013/08

DOI： 10.1121/1.4812870 　

ISSN： 0001-4966
Changes in backscatter of liver tissue due to thermal coagulation induced by focused ultrasound Peer-reviewed

Takashi Shishitani, Ryo Matsuzawa, Shin Yoshizawa, Shin-ichiro Umemura

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA　134　(2)　1724-1730　2013/08

DOI： 10.1121/1.4813104 　

ISSN： 0001-4966
Optical Phase Contrast Mapping of Highly Focused Ultrasonic Fields Peer-reviewed

Soichiro Harigane, Ryo Miyasaka, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　52　(7)　07HF07　2013/07

DOI： 10.7567/JJAP.52.07HF07 　

ISSN： 0021-4922

eISSN： 1347-4065
Large Volume Coagulation Utilizing Multiple Cavitation Clouds Generated by Array Transducer Driven by 32 Channel Drive Circuits Peer-reviewed

Kotaro Nakamura, Ayumu Asai, Hiroshi Sasaki, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　52　(7)　07HF10　2013/07

DOI： 10.7567/JJAP.52.07HF10 　

ISSN： 0021-4922

eISSN： 1347-4065
Enhancement of Focused Ultrasound Treatment by Acoustically Generated Microbubbles Peer-reviewed

Shin-ichiro Umemura, Shin Yoshizawa, Ryo Takagi, Yuta Inaba, Jun Yasuda

JAPANESE JOURNAL OF APPLIED PHYSICS　52　(7)　07HA02　2013/07

DOI： 10.7567/JJAP.52.07HA02 　

ISSN： 0021-4922

eISSN： 1347-4065
Efficient Generation of Cavitation Bubbles in Gel Phantom by Ultrasound Exposure with Negative-Followed by Positive-Peak-Pressure-Emphasized Waves Peer-reviewed

Jun Yasuda, Ayumu Asai, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　52　(7)　07HF11　2013/07

DOI： 10.7567/JJAP.52.07HF11 　

ISSN： 0021-4922

eISSN： 1347-4065
Analysis of Temperature Rise Induced by High-Intensity Focused Ultrasound in Tissue-Mimicking Gel Considering Cavitation Bubbles Peer-reviewed

Ayumu Asai, Hiroki Okano, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　52　(7)　07HF02　2013/07

DOI： 10.7567/JJAP.52.07HF02 　

ISSN： 0021-4922

eISSN： 1347-4065
Therapeutic Array Transducer Element Using Coresonance between Hemispherical Piezoceramic Shell and Water Sphere: Effect of Load Masses of Support and Electric Contact Peer-reviewed

Kenji Otsu, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　51　(7)　07GF24　2012/07

DOI： 10.1143/JJAP.51.07GF24 　

ISSN： 0021-4922
Three-Dimensional Quantitative Optical Measurement of Asymmetrically Focused Ultrasound Pressure Field Peer-reviewed

Yuta Shimazaki, Soichiro Harigane, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　51　(7)　07GF25　2012/07

DOI： 10.1143/JJAP.51.07GF25 　

ISSN： 0021-4922
Thermal Simulation of Cavitation-Enhanced Ultrasonic Heating Verified with Tissue-Mimicking Gel Peer-reviewed

Tatsuya Moriyama, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　51　(7)　07GF27　2012/07

DOI： 10.1143/JJAP.51.07GF27 　

ISSN： 0021-4922
High Voltage Staircase Drive Circuit for Triggered High-Intensity Focused Ultrasound Treatment Peer-reviewed

Keisuke Takada, Jumpei Okada, Kotaro Nakamura, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　51　(7)　07GF23　2012/07

DOI： 10.1143/JJAP.51.07GF23 　

ISSN： 0021-4922
Monitoring of Lesion Induced by High-Intensity Focused Ultrasound Using Correlation Method Based on Block Matching Peer-reviewed

Ryo Matsuzawa, Takashi Shishitani, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　51　(7)　07GF26　2012/07

DOI： 10.1143/JJAP.51.07GF26 　

ISSN： 0021-4922
Quantitative Measurement of Focused Ultrasound Pressure Field Using Subtraction Shadowgraph Peer-reviewed

Ryosuke Omura, Yuta Shimazaki, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　50　(7)　07HC07　2011/07

DOI： 10.1143/JJAP.50.07HC07 　

ISSN： 0021-4922
Breathing-Mode Ceramic Element for Therapeutic Array Transducer Peer-reviewed

Kenji Otsu, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　50　(7)　07HC02　2011/07

DOI： 10.1143/JJAP.50.07HC02 　

ISSN： 0021-4922
Ultrasonic Coagulation of Large Tissue Region by Generating Multiple Cavitation Clouds in Direction Perpendicular to Ultrasound Propagation Peer-reviewed

Yuta Inaba, Moriyama Tatsuya, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　50　(7)　07HF13　2011/07

DOI： 10.1143/JJAP.50.07HF13 　

ISSN： 0021-4922
Sonodynamic Therapy with 5-Aminolevulinic Acid and Focused Ultrasound for Deep-seated Intracranial Glioma in Rat Peer-reviewed

Tadahiro Ohmura, Takeo Fukushima, Hirotomo Shibaguchi, Shin Yoshizawa, Tooru Inoue, Masahide Kuroki, Kazunari Sasaki, Shin-Ichiro Umemura

ANTICANCER RESEARCH　31　(7)　2527-2533　2011/07

ISSN： 0250-7005
Analysis of High-Intensity Focused Ultrasound Source Using Time Reversal: Effect of Lamb-Like Waves Peer-reviewed

Yasuhiro Kaneshima, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　50　(4)　047301　2011/04

DOI： 10.1143/JJAP.50.047301 　

ISSN： 0021-4922

eISSN： 1347-4065
Cavitation inception by dual-frequency excitation in high-intensity focused ultrasound treatment Peer-reviewed

Takagi, R.a, Yoshizawa, S., Umemura, S.-I

Jpn. J. Appl. Phys.　50　(7 PART 2)　07HF14-07HF14-5　2011
Publisher: The Japan Society of Applied Physics
DOI： 10.1143/JJAP.50.07HF14 　

ISSN： 0021-4922

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In our previous study, we proposed a "triggered high-intensity focused ultrasound (HIFU)" exposure sequence, in which a high-intensity triggering pulse was irradiated just before CW heating waves, to accelerate HIFU treatment. In this study, the second-harmonic was superimposed to the triggering pulse, and the cavitation threshold was investigated by comparing different schemes of second-harmonic superimposition including the case of single-frequency exposure through detecting the subharmonic emission and high-speed camera observation. The experimental results show that cavitation bubbles can be generated most efficiently by using negative-peak-pressure emphasized waves followed by positive-peak-pressure emphasized waves.
The influence of the insonation conditions of pulsed ultrasound on microbubble volumetric oscillations (On the mechanical index and the oscillation characteristics) Peer-reviewed

Takeshi Miyamoto, Shin Yoshizawa, Yoichiro Matsumoto

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　77　(774)　264-273　2011

DOI： 10.1299/kikaib.77.264 　

ISSN： 0387-5016
Enhancement of localized heating by ultrasonically induced cavitation in high intensity focused ultrasound treatment Peer-reviewed

Ryo Takagi, Shin Yoshizawa, Shin-Ichiro Umemura

Japanese Journal of Applied Physics　49　(7)　07HF21　2010/07

DOI： 10.1143/JJAP.49.07HF21 　

ISSN： 0021-4922 1347-4065
Staircase-Voltage Metal-Oxide-Semiconductor Field-Effect Transistor Driver Circuit for Therapeutic Ultrasound Peer-reviewed

Kosuke Moro, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　49　(7)　07HF02　2010

DOI： 10.1143/JJAP.49.07HF02 　

ISSN： 0021-4922
Coagulation of Large Regions by Creating Multiple Cavitation Clouds for High Intensity Focused Ultrasound Treatment Peer-reviewed

Yuta Inaba, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　49　(7)　07HF22　2010

DOI： 10.1143/JJAP.49.07HF22 　

ISSN： 0021-4922
Acoustic Impedance Evaluation of High-Intensity-Focused-Ultrasound Exposed Chicken Breast Muscle Using Ultrasonic Microscopy Peer-reviewed

Takashi Shishitani, Shin Yoshizawa, Shin-ichiro Umemura

JAPANESE JOURNAL OF APPLIED PHYSICS　49　(7)　07HF04　2010

DOI： 10.1143/JJAP.49.07HF04 　

ISSN： 0021-4922
High intensity focused ultrasound lithotripsy with cavitating microbubbles Peer-reviewed

Shin Yoshizawa, Teiichiro Ikeda, Akira Ito, Ryuhei Ota, Shu Takagi, Yoichiro Matsumoto

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING　47　(8)　851-860　2009/08

DOI： 10.1007/s11517-009-0471-y 　

ISSN： 0140-0118
G1501-1-1 Development of acoustic pressure scanner for the Non-Invasive Ultrasound Theragnostic System by HIFU

SEO Joonho, KOIZUMI Norihiro, SUZUKI Yugo, NOMIYA Akira, YOSHIZAWA Shin, YOSHINAKA Kiyoshi, SUGITA Naohiko, HOMMA Yukio, MATSUMOTO Yoichiro, MITSUISHI Mamoru

The proceedings of the JSME annual meeting　2009　131-132　2009
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2009.5.0_131 　

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We propose an automated needle hydrophone based scanning system to obtain high-resolution planar acoustic pressure distribution generated by high intensity focused ultrasound (HIFU). The preoperative scanning plan manipulates the position of HIFU transducer and automates the acquisition of spatial acoustic pressure distribution. In particular, a method to minimize the displacement error induced by the time delay improves the scanning speed problem of the conventional needle hydrophone based scan system. Moreover, the noise-robust and automatic focus searching algorithm using Gaussian curve fitting reduces a total number of iterations as well as prevents divergence of searching the initial scanning position.
Growth of an oscillating microbubble in an ultrasound field (Enhancement of rectified diffusion with a dual-frequency excitation method) Peer-reviewed

Shin Yoshizawa, Shu Takagi, Yoichiro Matsumoto

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　75　(752)　710-717　2009
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.75.752_710 　

ISSN： 0387-5016
The Feed-Forward Controller of the Integrated System for Non-Invasive Ultrasound Diagnosis and Treatment Peer-reviewed

N. Koizumi, K. Ota, D. Lee, S. Yoshizawa, A. Ito, Y. Kaneko, K. Yoshinaka, Y. Matsumoto, M. Mitsuishi

J. Robotics Mechatronics　20　(1)　89-97　2008
4341 A Study on Technologizing and Digitalization of Skills in Medical Ultrasound Diagnosis and Therapy

KOIZUMI Norihiro, OTA Kohei, LEE Deukhee, YOSHIZAWA Shin, ITOH Akira, NAGOSHI Mitsuru, HASHIZUME Hiroyuki, MATSUMOTO Yoichiro, MITSUISHI Mamoru

The proceedings of the JSME annual meeting　2007　535-536　2007
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2007.5.0_535 　

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We have been studying the technologizing of skill of the medical doctor in the medical diagnosis and therapy. In this paper, we propose a method of decomposing and reconstructing required functions in medical ultrasound diagnosis and therapy.
4340 Real-time 3D tracking of kidney stones using ultrasound RF echo signals

LEE Deukhee, KOIZUMI Norihiro, OTA Kohei, YOSHIZAWA Shin, ITOH Akira, MATSUMOTO Yoichiro, MITSUISHI Mamoru

The proceedings of the JSME annual meeting　2007　533-534　2007
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2007.5.0_533 　

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For non-invasive 3D tracking of a target deep within a body, ultrasound-based visual servoing system is proposed. The ultrasound-based visual servoing system uses an ultrasound scanner for visual sensing. Two ultrasound probes equipped on the ultrasound scanner are located at the end-effector of a XYZ stage machine, and their scan planes parallel with XZ plane and YZ plane of the XYZ stage machine. The two sectional images of a target object in scan images of two ultrasound probes are registered as model images for pattern matching algorithm, respectively. 3D movement of the target object is sensed by pattern matching of the model images in input scan images. Displacement of the target between two successive frames decreases the accuracy of pattern matching. Therefore, scanning frame rate should be high enough to maintain the displacement of the target below threshold. Frame rate of ultrasound probes is adjustable through changing the view angle. Therefore, echo signals of ultrasound probes are used directly. Moreover, in order to save processing cost, image-based control method is used.
Cloud cavitation control for lithotripsy using high intensity focused ultrasound Peer-reviewed

Teiichiro Ikeda, Shin Yoshizawa, Masataka Tosaki, John S. Allen, Shu Takagi, Nobutaka Ohta, Tadaichi Kitamura, Yoichiro Matsumoto

ULTRASOUND IN MEDICINE AND BIOLOGY　32　(9)　1383-1397　2006/09

DOI： 10.1016/j.ultrasmedbio.2006.05.010 　

ISSN： 0301-5629
Nonlinear behavior of the collapse of a spherical bubble cloud Peer-reviewed

Yoshizawa, S, Ikeda, T, Takagi, S, Matsumoto, Y

Transactions of the Japan Society of Mechanical Engineers　72　(3)　620-627　2006

DOI： 10.1299/kikaib.72.620 　
Medical ultrasound with microbubbles Peer-reviewed

Y Matsumoto, JS Allen, S Yoshizawa, T Ikeda, Y Kaneko

EXPERIMENTAL THERMAL AND FLUID SCIENCE　29　(3)　255-265　2005/03

DOI： 10.1016/j.expthermflusci.2004.05.008 　

ISSN： 0894-1777
Behaviour of a bubble cluster in an ultrasound field Peer-reviewed

Y Matsumoto, S Yoshizawa

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS　47　(6-7)　591-601　2005/02

DOI： 10.1002/fld.833 　

ISSN： 0271-2091
Renal stone comminution utilizing cloud cavitation erosion (1st report, the control of cloud cavitation) Peer-reviewed

Teiichiro Ikeda, Shin Yoshizawa, Masataka Tosaki, Yukio Kaneko, Shu Takagi, Yoichiro Matsumoto

Nippon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　70　(692)　904-911　2004
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.70.904 　

ISSN： 0387-5016

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Misc. 197

High frequency ultrasound / photoacoustic imaging at Tohoku University

西條芳文, 新楯諒, 鈴木陸, 石井琢郎, 荒川元孝, 梅村晋一郎, 吉澤晋, 長岡亮, 小林和人, 根本隆治

超音波医学 Supplement　49　2022

ISSN： 1881-9311
切除不能膵癌に対する薬剤併用High intensity focused ultrasound(HIFU)治療

祖父尼淳, 村垣善浩, 梅村晋一郎, 岡本淳, 吉澤晋, 糸井隆夫

超音波医学　47　(Suppl.)　S325-S325　2020/11
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
半球型アレイトランスデューサと4方向傾斜レーザ照射による3次元光音響イメージング

森野太介, 新楯諒, 林瑛己, 長岡亮, 吉澤晋, 梅村晋一郎, 西條芳文

超音波医学　47　(Suppl.)　S524-S524　2020/11
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
Experimental Investigation of Relationship between Coagulation Size and Estimated Distribution of HIFU Heat Source from Displacement Distribution by Acoustic Radiation Force Imaging

Hiroki Yabata, Shin Ichiro Umemura, Shin Yoshizawa

IEEE International Ultrasonics Symposium, IUS　2020-September　2020/09/07

DOI： 10.1109/IUS46767.2020.9251597 　

ISSN： 1948-5719

eISSN： 1948-5727
Investigation on Ultrasonic Exposure Sequence by Luminol Sonochemiluminescence for Highly Effective Sonodynamic Treatment

Kenk Tsukahara, Shin Ichiro Umemura, Shin Yoshizawa

IEEE International Ultrasonics Symposium, IUS　2020-September　2020/09/07

DOI： 10.1109/IUS46767.2020.9251776 　

ISSN： 1948-5719

eISSN： 1948-5727
Effect of alternate transmission of split apertures on bubble behavior and temperature rise for bubble-enhanced ultrasound treatment

Sayaka Ito, Shin Ichiro Umemura, Shin Yoshizawa

IEEE International Ultrasonics Symposium, IUS　2020-September　2020/09/07

DOI： 10.1109/IUS46767.2020.9251407 　

ISSN： 1948-5719

eISSN： 1948-5727
Three-dimensional photoacoustic imaging using a hemispherical array transducer and four way oblique laser irradiation

森野太介, 新楯諒, 林瑛己, 長岡亮, 吉澤晋, 梅村晋一郎, 西條芳文

超音波医学 Supplement　47　2020

ISSN： 1881-9311
高周波数帯域の光音響信号による細胞レベルのイメージング

西條芳文, 新楯諒, 高橋爽, 平塚竜基, 石井琢郎, 吉澤晋, 梅村晋一郎, 長岡亮, 岩崎秀明, 伊田泰一郎

乳腺甲状腺超音波医学　9　(4)　2020

ISSN： 2187-2880
PDT・PDDの新応用・新技術音響力学的療法によるがん治療 SDTはPDTを超えられるか

小西良幸, 堀瀬友貴, 前田真法, 岡本淳, 生田聡子, 岡本芳晴, 石井宏志, 吉澤晋, 梅村晋一朗, 祖父尼淳, 正宗賢, 伊関洋, 西山伸宏, 片岡一則, 村垣善浩

日本レーザー医学会誌　40　(Suppl.)　S63-S63　2019/11
Publisher: (NPO)日本レーザー医学会
ISSN： 0288-6200

eISSN： 1881-1639
光超音波トモグラフィにおける光超音波信号の初期位相の補正による深さ分解能の改善に関する研究 : 高空間分解能化を目指して (特集超音波を使用した医療のあり方を探る(1))

長岡亮, 吉澤晋, 梅村晋一郎, 西條芳文

超音波techno　31　(3)　70-74　2019/05
Publisher: 日本工業出版
ISSN： 0916-2410
高周波数アニュラアレイセンサによる被写界深度の拡大

藤井佳祐, 佐藤泰, 菅野尚哉, 新楯諒, 小林和人, 吉澤晋, 梅村晋一郎, 西條芳文

電子情報通信学会技術研究報告　119　(211(US2019 46-56))　2019

ISSN： 0913-5685
Comparative study of one-way vertical illumination and four-way oblique illumination in three-dimensional photoacoustic imaging using a hemispherical array transducer

森野太介, 新楯諒, 長岡亮, 吉澤晋, 梅村晋一郎, 西條芳文

電子情報通信学会技術研究報告　119　(211(US2019 46-56))　2019

ISSN： 0913-5685
Visualization of skin morphology and microcirculation with high frequency ultrasound and dual-wavelength photoacoustic microscope

Yoshifumi Saijo, Taiichiro Ida, Hideaki Iwazaki, Jun Miyajima, Huabin Tang, Ryo Shintate, Kanta Sato, Tatsuki Hiratsuka, Shin Yoshizawa, Shinichiro Umemura

Progress in Biomedical Optics and Imaging - Proceedings of SPIE　10878　2019

DOI： 10.1117/12.2508599 　

ISSN： 1605-7422
切除不能難治癌に対する音響力学的療法の安全性に関する検討

祖父尼淳, 村垣善浩, 藤田充, 朝井靖二, 伊関洋, 正宗賢, 岡本淳, 小西良幸, 堀瀬友貴, 生田聡子, 岸本眞治, 泉美喜雄, 吉澤晋, 梅村晋一郎, 糸井隆夫

日本消化器病学会雑誌　115　(臨増大会)　A806-A806　2018/10
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
超音波治療の最前線-基礎と臨床- 切除不能難治癌に対する集束超音波(HIFU)治療と音響力学的治療(SDT)

祖父尼淳, 村垣善浩, 佐野隆友, 藤田充, 朝井靖二, 伊関洋, 正宗賢, 岡本淳, 小西良幸, 堀瀬友貴, 生田聡子, 岸本眞治, 泉美喜雄, 吉澤晋, 梅村晋一郎, 糸井隆夫

Thermal Medicine　34　(Suppl.)　67-67　2018/08
Publisher: (一社)日本ハイパーサーミア学会
ISSN： 1882-2576
集束超音波治療(FUS)の最前線集束超音波とドラッグデリバリーシステムを組み合わせた音響力学的療法の基礎と臨床試験

村垣善浩, 小西良幸, 堀瀬友貴, 岡本淳, 吉澤晋, 岡本芳晴, 祖父尼淳, 西山伸宏, 片岡一則, 正宗賢

Neurosonology　31　(増刊)　52-52　2018/06
Publisher: (一社)日本脳神経超音波学会
ISSN： 0917-074X
焦点ナビゲーション法のHIFU治療への応用

瀬尾晃平, 市塚清健, イズデプスキ龍也, 西井彰悟, 土肥聡, 岩崎亮祐, 高木亮, 吉澤晋, 梅村晋一郎, 関沢明彦

超音波医学　45　(Suppl.)　S560-S560　2018/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
HIFU照射方式の違いによるブタ腎実質焼灼の比較検証

イズデプスキ龍也, 瀬尾晃平, 西井彰悟, 土肥聡, 高木亮, 吉澤晋, 梅村晋一郎, 関沢明彦, 市塚清健

超音波医学　45　(Suppl.)　S709-S709　2018/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
皮膚熱傷を低減させるためのHIFU照射プロトコールの検証

西井彰悟, 瀬尾晃平, イズデプスキ龍也, 土肥聡, 岩崎亮祐, 高木亮, 吉沢晋, 梅村晋一郎, 関沢明彦, 市塚清健

超音波医学　45　(Suppl.)　S709-S709　2018/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
超音波によるtheranostics(診断と治療)の広がり音響力学的療法におけるセラノスティクス

村垣善浩, 小西良幸, 吉澤晋, 岡本芳晴, 祖父尼淳, 玉野聡, 植山剛, 竹前和久, 西山伸宏, 片岡一則

超音波医学　45　(Suppl.)　S186-S186　2018/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
超音波によるtheranostics(診断と治療)の広がり切除不能難治癌に対する集束超音波治療と音響力学的治療

祖父尼淳, 村垣善浩, 藤田充, 朝井靖二, 岡本淳, 小西良幸, 堀瀬友貴, 吉澤晋, 梅村晋一郎, 糸井隆夫

超音波医学　45　(Suppl.)　S186-S186　2018/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
音響力学的療法によるがん治療

岡本淳, 村垣善浩, 正宗賢, 伊関洋, 小西良幸, 堀瀬友貴, 清水京子, 糸井隆夫, 祖父尼淳, 梅村晋一郎, 吉澤晋, 高木亨, 岡本芳晴, 玉野聡, 植山剛, 竹前和久

未来医学　(31)　73-78　2018/02/15
Publisher: (一社)未来医学研究会
DOI： 10.20780/00031872 　

ISSN： 0910-9870
Basic study on ultrasonic tissue monitoring using 1.5-dimensional ultrasound phased array for ultrasound-guided high intensity focused ultrasound treatment Peer-reviewed

Ryo Takagi, Shin Yoshizawa, Shin Ichiro Umemura

IEEE International Ultrasonics Symposium, IUS　2017/10/31
Publisher: IEEE Computer Society
DOI： 10.1109/ULTSYM.2017.8092624 　

ISSN： 1948-5719

eISSN： 1948-5727
Three dimensional pressure field measurement of focused ultrasound by optical phase contrast method Peer-reviewed

Shin Yoshizawa, Takuya Nakamura, Yohei Sasaki, Maxime Lafond, Shin Ichiro Umemura

IEEE International Ultrasonics Symposium, IUS　2017/10/31
Publisher: IEEE Computer Society
DOI： 10.1109/ULTSYM.2017.8091908 　

ISSN： 1948-5719

eISSN： 1948-5727
Prediction of thermal coagulation by short-pulse pre-exposure for cavitation-enhanced ultrasonic heating Peer-reviewed

Ryosuke Iwasaki, Ryo Takagi, Shin Yoshizawa, Shin Ichiro Umemura

IEEE International Ultrasonics Symposium, IUS　2017/10/31
Publisher: IEEE Computer Society
DOI： 10.1109/ULTSYM.2017.8092354 　

ISSN： 1948-5719

eISSN： 1948-5727
Visualization of the microcirculation in micro vasculatures by photoacoustic tomography with high frequency spherical array transducer Peer-reviewed

Ryo Nagaoka, Takuya Tabata, Ryo Takagi, Shin Yoshizawa, Shin Ichiro Umemura, Yoshifumi Saijo

IEEE International Ultrasonics Symposium, IUS　2017/10/31
Publisher: IEEE Computer Society
DOI： 10.1109/ULTSYM.2017.8092091 　

ISSN： 1948-5719

eISSN： 1948-5727
Differentiation of vein and lymphatic vessel by photoacoustic imaging system with parabolic array transducer and tunable laser Peer-reviewed

Takuya Tabata, Ryo Nagaoka, Shin Yoshizawa, Shin Ichiro Umernura, Yoshifumi Saijo

IEEE International Ultrasonics Symposium, IUS　2017/10/31

DOI： 10.1109/ULTSYM.2017.8091669 　

ISSN： 1948-5719

eISSN： 1948-5727
Effect of HIFU exposure method to suppress standing waves on cavitation generation

117　(227)　33-37　2017/10/05
Publisher: 電子情報通信学会
ISSN： 0913-5685
進化する超音波治療技術の最前線 2)キャビテーション援用超音波加熱におけるワイドビーム超音波照射の加熱凝固領域に対する影響=超音波伝播の非線形性による超音波加熱増強効果を低減する=

吉澤晋, 梅村晋一郎

超音波Techno　29　(5)　62-67　2017/09
Publisher: 日本工業出版
ISSN： 0916-2410
TRAPシーケンスにおける低侵襲胎児治療に対する第二世代HIFUシステムの評価

瀬尾晃平, 市塚清健, 岡井崇, 仲村将光, 長谷川潤一, 松岡隆, 北代祐三, 住江正大, 月森清巳, 吉澤晋, 梅村晋一郎, 関沢明彦

昭和学士会雑誌　77　(2)　241-241　2017/04
Publisher: 昭和大学学士会
ISSN： 2187-719X

eISSN： 2188-529X
HIFUの臨床応用 HIFUによる胎児治療

市塚清健, 瀬尾晃平, 松岡隆, 仲村将光, 高木亮, 吉澤晋, 梅村晋一郎, 岡井崇

超音波医学　44　(Suppl.)　S179-S179　2017/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
HIFUを用いたTRAP sequenceに対する胎児治療の成績と今後の課題

瀬尾晃平, 市塚清健, 岡井崇, 松岡隆, 高木亮, 吉澤晋, 梅村晋一郎, 関沢明彦

超音波医学　44　(Suppl.)　S579-S579　2017/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
Quantitative Measurement of Pulsed Ultrasonic Pressure Field using Optical Phase Contrast Method and Acoustic Holography

116　(419)　5-10　2017/01/25
Publisher: 電子情報通信学会
ISSN： 0913-5685
Effectiveness of High-Speed Imaging on Predicting Thermal Coagulation Utilizing Acoustic Radiation Force by Pulsed High-Intensity Focused Ultrasound

116　(419)　11-15　2017/01/25
Publisher: 電子情報通信学会
ISSN： 0913-5685
Development in Method to Reduce Temperature Rise near Tissue Boundary in Cavitation-Enhanced High-Intensity Focused Ultrasound Treatment

116　(419)　17-21　2017/01/25
Publisher: 電子情報通信学会
ISSN： 0913-5685
Study of Simulation of Optical Propagation for Phase Retrieval in Shadowgraph of Ultrasound Field

116　(241)　23-27　2016/10/07
Publisher: 電子情報通信学会
ISSN： 0913-5685
Study on Control of Coagulation Size Induced by Bubble-Enhanced Ultrasound Heating Using Scattered Ultrasound Signal from Focal Region of Therapeutic Ultrasound

116　(241)　11-15　2016/10/07
Publisher: 電子情報通信学会
ISSN： 0913-5685
Analysis of cavitation bubbles generated by high-intensity focused ultrasound in biological tissue using high-speed optical and acoustic imaging

116　(241)　17-22　2016/10/07
Publisher: 電子情報通信学会
ISSN： 0913-5685
―音響に関する施設と装置―強力集束超音波装置(医用超音波装置)

吉澤晋

日本音響学会誌　72　(9)　576‐577　2016/09/01

DOI： 10.20697/jasj.72.9_576 　

ISSN： 0369-4232
先進医療に寄与する超音波技術頸動脈壁の粘弾性計測に関する検討=生体由来の拍動微小変位の速度分散を用いて=

長岡亮, 荒川元孝, 吉澤晋, 梅村晋一郎, 西條芳文, 小林和人

超音波Techno　28　(3)　10‐14　2016/06/01

ISSN： 0916-2410
先進医療に寄与する超音波技術強力集束超音波治療の組織変化モニタリング=高速超音波イメージングによる非相関モニタリング=

吉澤晋, 佐々木翔也, 高木亮, 梅村晋一郎

超音波Techno　28　(3)　39‐42　2016/06/01

ISSN： 0916-2410
先進医療に寄与する超音波技術強力集束超音波治療のモニター時における治療用超音波ノイズの除去

高木亮, 吉澤晋, 梅村晋一郎

超音波Techno　28　(3)　1‐5　2016/06/01

ISSN： 0916-2410
超音波治療の臨床応用最前線 HIFUによる胎児治療

市塚清健, 瀬尾晃平, 青木弘子, 松岡隆, 長谷川潤一, 石川哲也, 岡井崇, 吉澤晋, 梅村晋一郎

超音波医学　43　(Suppl.)　S238-S238　2016/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
HIFUにおける焦点のナビゲーション及びキャビテーションの可視化に関する基礎研究

瀬尾晃平, 市塚清健, 吉澤晋, 梅村晋一郎, 仲村将光, 長谷川潤一, 松岡隆, 関沢明彦, 岡井崇

超音波医学　43　(Suppl.)　S713-S713　2016/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
超音波治療の効果判定とその臨床経過観察癌に対する薬剤併用集束超音波治療(Application of Therapeutic Ultrasound and Monitoring Its Clinical Outcome High intensity therapeutic ultrasound combined with drug for cancer patients)

村垣善浩, 前田真法, 伊関洋, 岡本淳, 岸本眞治, 正宗賢, 高木亮, 吉澤晋, 梅村晋一郎

超音波医学　43　(Suppl.)　S217-S217　2016/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
気泡援用集束超音波治療の安全性向上に関する研究

坂本和広, 高木亮, 吉澤晋, 梅村晋一郎

電気関係学会東北支部連合大会講演論文集　2016　189-189　2016
Publisher: 電気関係学会東北支部連合大会実行委員会
DOI： 10.11528/tsjc.2016.0_189 　
音響キャビテーションによる活性酸素生成における超音波焦点走査の影響

西高慎也, 高木亮, 吉澤晋, 梅村晋一郎

電気関係学会東北支部連合大会講演論文集　2016　187-187　2016
Publisher: 電気関係学会東北支部連合大会実行委員会
DOI： 10.11528/tsjc.2016.0_187 　
光学的測定と音響ホログラフィー解析による高強度超音波音場の定量測定

中村拓也, 大山誠司, 花山洋貴, 高木亮, 吉澤晋, 梅村晋一郎

電気関係学会東北支部連合大会講演論文集　2016　178-178　2016
Publisher: 電気関係学会東北支部連合大会実行委員会
DOI： 10.11528/tsjc.2016.0_178 　
Focal zone visualization by absorption imaging method to predict thermal lesion formation in ultrasonic thermal therapy

Tohoku-Section Joint Convention Record of Institutes of Electrical and Information Engineers, Japan　2016　25-25　2016
Publisher: Organizing Committee of Tohoku-Section Joint Convention of Institutes of Electrical and Information Engineers, Japan
DOI： 10.11528/tsjc.2016.0_25 　
Focused Ultrasound and Lithotripsy Peer-reviewed

Teiichiro Ikeda, Shin Yoshizawa, Norihiro Koizumi, Mamoru Mitsuishi, Yoichiro Matsumoto

THERAPEUTIC ULTRASOUND　880　113-129　2016

DOI： 10.1007/978-3-319-22536-4_7 　

ISSN： 0065-2598
A Study of the driving circuit for array transducer considering its impedance properties Peer-reviewed

Hayato Jimbo, Kota Goto, Shin Yoshizawa, Shin Ichiro Umemura

2015 IEEE International Ultrasonics Symposium, IUS 2015　7329179　2015/11/13

DOI： 10.1109/ULTSYM.2015.0429 　

ISSN： 1948-5719
Efficient generation of reactive oxygen species sonochemically generated by cavitation bubbles Peer-reviewed

Jun Yasuda, Shin Yoshizawa, Shin Ichiro Umemura

2015 IEEE International Ultrasonics Symposium, IUS 2015　7329535　2015/11/13

DOI： 10.1109/ULTSYM.2015.0402 　

ISSN： 1948-5719
Quantitative measurement of pulsed ultrasound pressure field using optical phase contrast Peer-reviewed

Seiji Oyama, Mohd Syahid, Jun Yasuda, Shin Yoshizawa, Shin Ichiro Umemura

2015 IEEE International Ultrasonics Symposium, IUS 2015　7329280　2015/11/13

DOI： 10.1109/ULTSYM.2015.0228 　

ISSN： 1948-5719
Study of ultrasound transducer which produces second harmonic superimposed signal Peer-reviewed

Zulfadhli Zaini, Shin Ichiro Umemura, Hayato Jimbo, Ryo Takagi, Shin Yoshizawa

2015 IEEE International Ultrasonics Symposium, IUS 2015　7329298　2015/11/13

DOI： 10.1109/ULTSYM.2015.0555 　

ISSN： 1948-5719
Monitoring of lesions induced by cavitation-enhanced high-intensity focused ultrasound using shear wave elastography Peer-reviewed

Ryosuke Iwasaki, Ryo Nagaoka, Yoshifumi Saijo, Shin Ichiro Umemura, Ryo Takagi, Hayato Jimbo, Shin Yoshizawa

2015 IEEE International Ultrasonics Symposium, IUS 2015　7329182　2015/11/13

DOI： 10.1109/ULTSYM.2015.0042 　

ISSN： 1948-5719
1P5-7 Study on Heavy Matching Layer Transducer Towards Producing Second Harmonic.

Zulfadhli Zaini, Osuga Masamizu, Jimbo Hayato, Yasuda Jun, Takagi Ryo, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　36　"1P5-7-1"-"1P5-7-2"　2015/11/05
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
1P5-11 Monitoring of High-Intensity Focused Ultrasound Treatment Using Shear Wave Elastography Induced by 2D Array Therapeutic Transducer

Iwasaki Ryosuke, Takagi Ryo, Nagaoka Ryo, Jimbo Hayato, Yoshizawa Shin, Saijo Yoshifumi, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　36　"1P5-11-1"-"1P5-11-2"　2015/11/05
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2E2-3 Real-time Treatment Feedback Using Novel Filter for Eliminating Therapeutic Ultrasound Noise in US-guided High-Intensity Focused Ultrasound Treatment

Takagi Ryo, Jimbo Hayato, Iwasaki Ryosuke, Tomiyasu Kentaro, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　36　"2E2-3-1"-"2E2-3-2"　2015/11/05
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-4 Efficient Generation of Cavitation Bubbles and Reactive Oxygen Species using Triggered HIFU Sequence for Sonodynamic Treatment

Yasuda Jun, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　36　"2P5-4-1"-"2P5-4-2"　2015/11/05
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3J1-3 Quantitative Measurement of Ultrasound Pressure Field by Optical Phase Contrast Method and Acoustic Holography

Oyama Seiji, Yasuda Jun, Hanayama Hiroki, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　36　"3J1-3-1"-"3J1-3-2"　2015/11/05
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-3 Advantage of Annular Focal Region Generated by Sector-Vortex Array in Cavitation-Enhanced High-Intensity Focused Ultrasound Treatment

Jimbo Hayato, Takagi Ryo, Goto Kota, Taguchi Kei, Yoshizawa Shin, Umemura Shinichiro

Proceedings of Symposium on Ultrasonic Electronics　36　"2P5-3-1"-"2P5-3-2"　2015/11/05
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-7 Study of Cavitation Behavior during High-Intensity Focused Ultrasound Exposure by Using Flash Imaging

Taguchi Kei, Takagi Ryo, Yasuda Jun, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　36　"2P5-7-1"-"2P5-7-2"　2015/11/05
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
Intrinsic elastography and its dependence on arterial flow volume Peer-reviewed

Ryo Nagaoka, Kazuto Kobayashi, Shin Yoshizawa, Shin Ichiro Umemura, Yoshifumi Saijo

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2015-November　6309-6312　2015/11/04

DOI： 10.1109/EMBC.2015.7319835 　

ISSN： 1557-170X
Quantitative assessment of reactive oxygen species generation by cavitation incepted efficiently using nonlinear propagation effect Peer-reviewed

Jun Yasuda, Shin Yoshizawa, Shin Ichiro Umemura

AIP Conference Proceedings　1685　040003　2015/10/28

DOI： 10.1063/1.4934398 　

ISSN： 0094-243X

eISSN： 1551-7616
医工連携と癌治療国産DDS製剤と集束超音波治療装置による音響力学的療法の実現

村垣善浩, 前田真法, 伊関洋, 岡本淳, 岸本眞治, 正宗賢, 吉澤晋, 梅村晋一郎

日本癌治療学会誌　50　(2)　447-448　2015/09
Publisher: (一社)日本癌治療学会
ISSN： 0021-4671
A Study of the Driving Circuit for Array Transducer Considering the Impedance Properties

JIMBO Hayato, GOTO Kota, YOSHIZAWA Shin, UMEMURA Shinnichiro

Technical report of IEICE. EA　114　(423)　39-43　2015/01/28
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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High-intensity focused ultrasound (HIFU) is a noninvasive method for cancer treatments, and one of the requirements for clinical use is to make the treatment more efficient. One of the approach, there is a multi-channel array transducer to enlarge treatment volume by making multiple focal points and scanning focal points. Since array transducer needs driving circuits for each channel, we have developed studying compact and high-efficiency driving circuits. In this study, we designed and made a driving circuit for array transducers considering the impedance properties. We compared new circuit and prior circuit by simulating its electrical power consumption and measuring focal pressure.
Quantitative Measurement of Pulsed Ultrasound Pressure Field Using Optical Phase Contrast

OYAMA Seiji, SYAHID Mohd, YASUDA Jun, YOSHIZAWA Shin, UMEMURA Shin-ichiro

Technical report of IEICE. EA　114　(423)　69-74　2015/01/28
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Establishment of fast and accurate measurement of ultrasound pressure field leads to the development of ultrasound application in medication. The most common method is a hydrophone scan which requires a long scanning time and disturbs the acoustic field. In this study, we used an optical phase contrast method for the measurement which enables a fast and noninterfering measurement. This method measures the modulated phase of light cause by the pulsed ultrasound pressure field. Then, we applied a CT algorithm to reconstruct the 3D ultrasound pressure field and measure the pressure field quantitatively. The result of optical phase contrast method was compared with that of hydrophone measurement and simulation and well agreement was achieved.
Monitoring of Cavitation Bubbles Induced by High-Intensity Focused Ultrasound in a Graphite Gel Phantom

TAGUCHI Kei, TAKAGI Ryo, YASUDA Jun, MIYASHITA Takuya, OYAMA Seiji, YOSHIZAWA Shin, UMEMURA Shin-ichiro

IEICE technical report. Ultrasonics　114　(422)　63-68　2015/01/28
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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High-intensity focused ultrasound (HIFU) treatment is a noninvasive treatment method in which ultrasound is focused to a target tissue such as cancer to be thermally coagulated. Cavitation bubbles can be used to provide efficient therapy. In this case, it is necessary to monitor cavitation bubbles. In this study, we examined the efficiency of high-speed pulse inversion imaging with plane wave transmission for monitoring cavitaion bubbles. Cavitation bubbles were generated and monitored by ultrasound imaging and high-speed photography in a graphite gel phantom. The result suggests that pulse inversion imaging is efficient when duration of bubble vibration is short after cavitation phenomenon.
Quantitative Measurement of Pulsed Ultrasound Pressure Field Using Optical Phase Contrast

OYAMA Seiji, SYAHID Mohd, YASUDA Jun, YOSHIZAWA Shin, UMEMURA Shin-ichiro

IEICE technical report. Ultrasonics　114　(422)　105-110　2015/01/28
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Establishment of fast and accurate measurement of ultrasound pressure field leads to the development of ultrasound application in medication. The most common method is a hydrophone scan which requires a long scanning time and disturbs the acoustic field. In this study, we used an optical phase contrast method for the measurement which enables a fast and noninterfering measurement. This method measures the modulated phase of light cause by the pulsed ultrasound pressure field. Then, we applied a CT algorithm to reconstruct the 3D ultrasound pressure field and measure the pressure field quantitatively. The result of optical phase contrast method was compared with that of hydrophone measurement and simulation and well agreement was achieved.
A Study of the Driving Circuit for Array Transducer Considering the Impedance Properties

JIMBO Hayato, GOTO Kota, YOSHIZAWA Shin, UMEMURA Shinnichiro

IEICE technical report. Ultrasonics　114　(422)　75-79　2015/01/28
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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High-intensity focused ultrasound (HIFU) is a noninvasive method for cancer treatments, and one of the requirements for clinical use is to make the treatment more efficient. One of the approach, there is a multi-channel array transducer to enlarge treatment volume by making multiple focal points and scanning focal points. Since array transducer needs driving circuits for each channel, we have developed studying compact and high-efficiency driving circuits. In this study, we designed and made a driving circuit for array transducers considering the impedance properties. We compared new circuit and prior circuit by simulating its electrical power consumption and measuring focal pressure.
2P5-3 Analysis of Ultrasound-Enhanced Heating in near and far Vicinity of Cavitation Area(Poster Session)

Miyashita Takuya, Yasuda Jun, Taguchi Kei, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　35　309-310　2014/12/03
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-10 Detection of Thermally-Induced Lesion Using Shear Wave Imaging in Cavitation-Enhanced High-Intensity Focused Ultrasound Therapy(Poster Session)

Iwasaki Ryosuke, Nagaoka Ryo, Takagi Ryo, Goto Kota, Yoshizawa Shin, Saijo Yoshifumi, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　35　323-324　2014/12/03
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3J3-2 Elimination of Therapeutic Ultrasound Noise from Pre-beamformed RF Data in Ultrasound Imaging for US-guided High-Intensity Focused Ultrasound Treatment(Biomedical Ultrasound III)

Takagi Ryo, Goto Kota, Jinbo Hayato, Matsuura Keiko, Iwasaki Ryosuke, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　35　393-394　2014/12/03
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-2 Analysis of Decorrelation in Ultrasonic Echo Signals Coincided with Tissue Change due to High-Intensity Focused Ultrasound Enhanced by Cavitation(Poster Session)

Matsuura Keiko, Takagi Ryo, Yanagisawa Yukari, Yoshizawa Shin, Kodama Tetsuya, Umemura Shim-ichiro

Proceedings of Symposium on Ultrasonic Electronics　35　307-308　2014/12/03
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-1 Effect of Controlled Offset of Focal Position in Cavitation Enhanced High Intensity Focused Ultrasound Treatment(Poster Session)

Goto Kota, Takagi Ryo, Jinbo Hayato, Miyashita Takuya, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　35　305-306　2014/12/03
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3P5-19 A Basic Study of Intrinsic Elastography Based on Propagation Velocity Distribution Induced by Artery Pulsation(Poster Session)

Nagaoka Ryo, Iwasaki Ryosuke, Arakawa Mototaka, Kobayashi Kazuto, Yoshizawa Shin, Umemura Shin-ichiro, Saijo Yoshifumi

Proceedings of Symposium on Ultrasonic Electronics　35　545-546　2014/12/03
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
1P5-22 Quantitative Assessment of Reactive Oxygen Sonochemically Generated by Cavitation Bubbles(Poster Session)

Yasuda Jun, Miyashita Takuya, Taguchi Kei, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　35　167-168　2014/12/03
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2E2-4 Quantitative Measurement of High Intensity Focused Ultrasound Pressure Field by Optical Phase Contrast Method Applying Non-Continuous Phase Unwrapping Algorithm(Biomedical Ultrasound I)

Syahid Mohd, Oyama Seiji, Yasuda Jun, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　35　197-198　2014/12/03
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
A Basic Study of Visualization of Propagation Velocity Distribution Induced by Arterial Pulsation

Nagaoka Ryo, Arakawa Mototaka, Kobayashi Kazuto, Yoshizawa Shin, Umemura Shin-ichiro, Saijo Yoshifumi

The Computational Mechanics Conference　2014　(27)　362-363　2014/11/22
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-026X
Measurement of propagation wave velocity of thyroid induced by pulsation Peer-reviewed

Ryo Nagaoka, Shin Yoshizawa, Shin Ichiro Umemura, Yoshifumi Saijo, Kazuto Kobayashi

IEEE International Ultrasonics Symposium, IUS　1136-1139　2014/10/20

DOI： 10.1109/ULTSYM.2014.0279 　

ISSN： 1948-5719

eISSN： 1948-5727
High frame-rate estimation of two-dimensional blood flow vector by bidirectional doppler ultrasound with parallel beamforming Peer-reviewed

Genta Masuno, Ryo Nagaoka, Osamu Akagawa, Shoya Sasaki, Shin Yoshizawa

Transactions of Japanese Society for Medical and Biological Engineering　52　331-O-332　2014/08/17
Publisher: Japan Soc. of Med. Electronics and Biol. Engineering
DOI： 10.11239/jsmbe.52.O-331 　

ISSN： 1347-443X 1881-4379
Focused ultrasound thermal treatment using cavitation-enhanced ultrasonic heating Peer-reviewed

Shin Yoshizawa, Ryo Takagi, Hiroshi Sasaki, Kota Goto, Nobutaka Abe, Shohei Kodera, Hiroshi Ishii, Takashi Suzuki, Yoshihiro Muragaki, Hiroshi Iseki, Shin-Ichiro Umemura

Transactions of Japanese Society for Medical and Biological Engineering　52　3-SY-4　2014/08/17
Publisher: Japan Soc. of Med. Electronics and Biol. Engineering
DOI： 10.11239/jsmbe.52.SY-3 　

ISSN： 1347-443X 1881-4379
Visualization of pulse propagation with high frame rate spatial compound imaging Peer-reviewed

Ryo Nagaoka, Genta Masuno, Kazuto Kobayashi, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo

Transactions of Japanese Society for Medical and Biological Engineering　52　353-O-354　2014/08/17
Publisher: Japan Soc. of Med. Electronics and Biol. Engineering
DOI： 10.11239/jsmbe.52.O-353 　

ISSN： 1347-443X 1881-4379
Elimination of HIFU Components in Monitoring of High-Intensity Focused Ultrasound Lesion Formation

TAKAGI Ryo, MATSUURA Keiko, IWASAKI Ryosuke, YOSHIZAWA Shin, UMEMURA Shin-ichiro

IEICE technical report. Ultrasonics　114　(102)　9-12　2014/06/23
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Ultrasonic detection of focal tissue coagulation thermally induced by high-intensity focused ultrasound (HIFU) has been difficult without the involvement of microbubbles. A significant length of interval between HIFU shots is set for monitoring target tissue to avoid interference between HIFU noise and RF echo signals in conventional ultrasound monitoring of HIFU treatment. This way, it is difficult to detect tissue changes in the order of milliseconds, which is required for dynamically controlling the HIFU exposure. In this study, a new filtering method to handle RF signals before beam forming is proposed, which will enable truly real-time detection of tissue coagulation during HIFU exposure.
超音波医学におけるバブル基礎から応用まで超音波生成したキャビテーション気泡の超音波観察

吉澤晋, 高木亮, 佐々木博史, 佐々木翔也, 阿部信隆, 小寺祥平, 村垣善浩, 伊関洋, 梅村晋一郎

超音波医学　41　(Suppl.)　S274-S274　2014/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
高速超音波イメージング下でのキャビテーション援用超音波加熱治療手法の開発

吉澤晋, 高木亮, 佐々木博史, 後藤功太, 阿部信隆, 小寺祥平, 村垣善浩, 伊関洋, 梅村晋一郎

超音波医学　41　(Suppl.)　S451-S451　2014/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
キャビテーションを用いた超音波加熱治療法

吉澤晋, 中村高太郎, 浅井歩, 佐々木博史, 梅村晋一郎

超音波テクノ　26　(2)　80-83　2014/04/01
Analysis on Cavitation Region Induced by Positive and Negative Acoustic Pressure

YASUDA Jun, MIYASHITA Takuya, YOSHIZAWA Shin, UMEMURA Shin-ichiro

IEICE technical report. Ultrasonics　113　(412)　15-20　2014/01/27
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Cavitation bubbles have much potential for therapeutic treatments such as high-intensity focused ultrasound (HIFU) treatment. In HIFU treatment method, highly efficient as well as controlled generation of them is important to utilize them effectively as well as safely. However, producing strong negative pressure for generating cavitation bubbles by focused ultrasound is difficult due to the nonlinear propagation. To solve this problem, we have suggested Dual Frequency Ultrasound Exposure method. In this study, cavitation bubbles generated by Dual Frequency Ultrasound Exposure were observed by high-speed camera, and acoustic pressure distribution around focal area was measured by automatic acoustic pressure measurement system. As a result, the measured negative and positive pressure distributions agreed well with the optically observed distributions of cavitation inception and cavitation cloud growth.
2B34 Highly efficient heating by cavitation bubbles in multiple focal spots in high intensity focused ultrasound treatment

GOTO Kota, SASAKI Hiroshi, MIYASHITA Takuya, YOSHIZAWA Shin, UMEMURA Shin-ichiro

2014　(26)　319-320　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2B36 Estimation of Coagulation Region by Using Ultrasonic Imaging in Presence of Cavitation Bubbles

MATSUURA Keiko, TAKAGI Ryo, SASAKI Syoya, YOSHIZAWA Shin, UMEMURA Shin-ichiro

2014　(26)　323-324　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2B21 Quantitative Measurement of High-Intensity Focused Ultrasound Pressure Field by Optical Phase Contrast

SYAHID Mohd, MIYASAKA Ryo, YASUDA Jun, YOSHIZAWA Shin, UMEMURA Shin-ichiro

2014　(26)　303-304　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2B33 Analysis of Cavitation-enhanced HIFU Heating by Taking Acoustic Emission from Cavitation Bubbles into Account

Miyashita Takuya, Yasuda Jun, Yoshizawa Shin, Umemura Shin-ichiro

2014　(26)　317-318　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
Quantitative Measurement of Highly Focused Ultrasound Pressure Field by Optical Shadowgraph Peer-reviewed

R. Miyasaka, S. Harigane, S. Yoshizawa, S. Umemura

3RD INTERNATIONAL SYMPOSIUM ON LASER ULTRASONICS AND ADVANCED SENSING　520　(1)　012026　2014

DOI： 10.1088/1742-6596/520/1/012026 　

ISSN： 1742-6588
2P5-19 Highly Efficient Cavitation-Enhanced Heating with Dual-Frequency Ultrasound Exposure in High-Intensity Focused Ultrasound Treatment(Poster Session)

Sasaki Hiroshi, Yasuda Jun, Takagi Ryo, Miyashita Takuya, Goto Kota, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　34　337-338　2013/11/20
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-7 Quantitative Measurement of Focused Ultrasound Pressure Field by Background-subtracted Shadowgraph Using Holographic Diffuser as Screen(Poster Session)

Miyasaka Ryo, Yasuda Jun, Syahid Mohd, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　34　313-314　2013/11/20
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3J5-2 Monitoring of High-Intensity Focused Ultrasound Lesion Formation Using Decorrelation Between High-Speed Ultrasonic Images by Parallel Beamforming(Biomedical Ultrasound 1)

Sasaki Shoya, Takagi Ryo, Matsuura Keiko, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　34　393-394　2013/11/20
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-18 Effects of Rose Bengal on Cavitation Generation in Gel Phantom Investigated using High-Speed Camera(Poster Session)

Yasuda Jun, Miyashita Takuya, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　34　335-336　2013/11/20
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3P5-19 Two-dimensional Blood Flow Vector obtained by Bidirectional Doppler Ultrasound with Parallel Beamforming(Poster Session)

Masuno Genta, Nagaoka Ryo, Sasaki Shoya, Yoshizawa Shin, Umemura Shinichiro, Saijo Yoshifumi

Proceedings of Symposium on Ultrasonic Electronics　34　527-528　2013/11/20
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
Adaptive 2-dimension Displacement Estimation on Medical Ultrasonography

YAMAMOTO Mariko, YOSHIZAWA Shin, UMEMURA Shin-ichiro

IEICE technical report. Ultrasonics　113　(284)　25-30　2013/11/11
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have applied the minimum variance adaptive beamformer to displacement estimation in medical ultrasound imaging and shown improvement in estimation accuracy compared to the conventional method using autocorrelation and Least-square method at low SNR. The proposed method calibrates the weights of trasnducer signals and more improvement was expected along the lateral axis than along the longitudinal axis, while comparable improvements were found by the numerical experiment.
Therapeutic Imaging Using Decorrelation of Ultrasound RF Signal in Cavitation-enhanced Ultrasound Thermal Therapy

MATSUURA Keiko, TAKAGI Ryo, SASAKI Syoya, YOSHIZAWA Shin, UMEMURA Shin-ichiro

IEICE technical report. Ultrasonics　113　(284)　31-36　2013/11/04
Publisher: The Institute of Electronics, Information and Communication Engineers

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HIFU is a medical technology to coagulate tissue by its acoustic energy. A dependable imaging technology is essential for establishing its accuracy and safety. Minor alternation of ultrasound RF signal in echography due to coagulation is focused in this study. By mapping the decrease in cross-correlation coefficient between frames, we succeeded in estimating the coagulate area in the existence of cavitation bubbles that were generated around the focal spot due to the high ultrasonic intensity.
Analysis of cavitation-enhanced heating and acoustic emission from cavitation in a focused ultrasound field

Miyashita Takuya, Yasuda Jun, Yoshizawa Shin, Umemura Shin-ichiro

IEICE technical report. Ultrasonics　113　(201)　19-24　2013/09/12
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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High-intensity focused ultrasound (HIFU) is a noninvasive method for cancer treatments. However, there is a problem that it takes for several hours to treat a large tumor. To shorten the treatment time, there is need for the development of a highly-efficient method. It is known that cavitation bubbles accelerate the HIFU heating treatment. In this study, the enhancement of the heating by cavitation was estimated in a numeral simulation solving a bio-heat transfer equation by increasing the absorption coefficients and heat source in and out of the volume of cavitation bubbles. The absorption coefficient and the amount of the generated heat were calculated by a curve fitting between the temperature rise in experiment and simulation. Finally, we investigated the accuracy of the model by measuring acoustic emission from cavitation in a focused ultrasound field.
【医療情報誘導治療の最新】 HIFU治療におけるマルチモダリティナビゲーションシステムの開発

村垣善浩, 阿部信隆, 仲本秀和, 荒井修, 鈴木孝司, 岡本淳, 小寺祥平, 石井宏志, 中丸小百合, 川畑健一, 吉澤晋, 梅村晋一郎, 伊関洋

映像情報Medical　45　(7)　597-603　2013/07
Publisher: 産業開発機構(株)
ISSN： 1346-1354
2A18 Quantitative Measurement of Highly Focused Ultrasound Pressure Field by Optical Shadowgraph

MIYASAKA Ryo, HARIGANE Soichiro, YOSHIZAWA Shin, UMEMURA Shin-ichiro

2013　(25)　267-268　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
2A17 Ultrasound Monitoring of Tissue Coagulation Induced by High-Intensity Focused Ultrasound

SASAKI Shoya, YOSHIZAWA Shin, UMEMURA Shin-ichiro

2013　(25)　265-266　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
2A16 Tissue coagulation enlarged by cavitation babbles in multiple focal spots in high intensity focused ultrasound treatment

SASAKI Hiroshi, NAKAMURA Kotaro, ASAI Ayumu, YOSIZAWA Shin, UMEMURA Shin-ichiro

2013　(25)　263-264　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
2A15 Analysis on Enhanced Ultrasonic Absorption by Cavitation Bubbles in Ultrasound Thermal Treatment

OKANO Hiroki, ASAI Ayumu, YASUDA Jun, YOSHIZAWA Shin, UMEMURA Shinichiro

2013　(25)　261-262　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
3I-1 Enhancement of Focal Ultrasonic Treatment by Microbubbles(Invited Talk 3)

Umemura Shin-ichiro, Kawabata Ken-ichi, Yoshizawa Shin

Proceedings of Symposium on Ultrasonic Electronics　33　407-408　2012/11/13
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pa5-7 Large Volume Coagulation Utilizing Multiple Cavitation Clouds Generated by 32 Channel Drive Circuits(Poster Session)

Nakamura Kotaro, Asai Ayumu, Takada Keisuke, Sasaki Hiroshi, Okano Hiroki, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　33　385-386　2012/11/13
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pa5-8 Efficient Generation of Cavitation bubbles in Gel Phantom by Dual-Frequency Ultrasound Exposure(Poster Session)

Yasuda Jun, Asai Ayumu, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　33　387-388　2012/11/13
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pa5-10 Effect of BSA Concentration on Cavitation Bubbles in Gel Phantom(Poster Session)

Asai Ayumu, Yasuda Jun, Okano Hiroki, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　33　391-392　2012/11/13
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
1J5-2 Optical Phase Contrast Mapping of Highly Focused Ultrasonic Fields(Biomedical Ultrasound)

Harigane Soichiro, Miyasaka Ryo, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　33　127-128　2012/11/13
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
実用化を見据えた研究・開発 PDTの発展に向けて先端医療機器開発における国際標準化の役割

岸本眞治, 村垣善浩, 岡本淳, 吉光喜太郎, 鈴木孝司, 伊関洋, 吉澤晋, 梅村晋一郎, 植松美幸, 松岡厚子, 阿部信隆, 仲本秀和, 鏑木正志, 川畑健一, 石井宏志

日本レーザー医学会誌　33　(3)　282-282　2012/10
Publisher: (NPO)日本レーザー医学会
ISSN： 0288-6200

eISSN： 1881-1639
新たな低侵襲治療を目指してトリガパルスを用いた高効率集束超音波治療

村垣善浩, 和田章秀, 阿部信隆, 仲本秀和, 伊関洋, 鈴木孝司, 梅村晋一郎, 吉澤晋, 川畑健一, 石井宏志, 吉光喜太郎, 岡本淳, 小西良幸

日本コンピュータ外科学会誌　14　(3)　158-159　2012/10
Publisher: (一社)日本コンピュータ外科学会
ISSN： 1344-9486

eISSN： 1884-5770
Enhancement of cavitation inception by second-harmonic superimposition Peer-reviewed

Shin Yoshizawa, Ryo Takagi, Jun Yasuda, Shin ichiro Umemura

AIP Conference Proceedings　1474　(1)　235-238　2012/05

DOI： 10.1063/1.4749339 　

ISSN： 0094-243X

eISSN： 1551-7616
Detection of HIFU-induced coagulation by motion-compensated decorrelation of RF echo signals Peer-reviewed

Shin Ichiro Umemura, Ryo Matsuzawa, Takashi Shishitani, Shin Yoshizawa

IEEE International Ultrasonics Symposium, IUS　2611-2614　2012

DOI： 10.1109/ULTSYM.2012.0654 　

ISSN： 1948-5719

eISSN： 1948-5727
Efficient generation of cavitation cloud by dual-frequency ultrasound exposure in optically transparent gel Peer-reviewed

Jun Yasuda, Ayumu Asai, Shin Yoshizawa, Shin Ichiro Umemura

IEEE International Ultrasonics Symposium, IUS　2607-2610　2012

DOI： 10.1109/ULTSYM.2012.0653 　

ISSN： 1948-5719

eISSN： 1948-5727
Optimization of phase shift of the transducer for high intensity focused ultrasound (HIFU) Peer-reviewed

Mariko Yamamoto, Shin Yoshizawa, Shin Ichiro Umemura

IEEE International Ultrasonics Symposium, IUS　1625-1628　2012

DOI： 10.1109/ULTSYM.2012.0407 　

ISSN： 1948-5719

eISSN： 1948-5727
Ultrasound image based visual tracking of kidney by utilizing multi-templates

FUNAMOTO T., KOIZUMI N., SEO J., NOMIYA A., YOSHIZAWA S., YOSHINAKA K., SUGITA N., MATSUMOTO Y., HOMMA Y., MITSUISHI M.

13　(3)　190-191　2011/11/22

ISSN： 1344-9486
3J5-2 Thermal simulation of cavitation enhanced ultrasonic heating verified with tissue mimicking gel(Medical Ultrasound)

Moriyama Tatsuya, Asai Ayumu, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　32　581-582　2011/11/08
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pb5-6 Simulated B-mode image from acoustic impedance map of HIFU-exposed specimen(Poster Session)

Shishitani Takashi, Matsuzawa Ryo, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　32　541-542　2011/11/08
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pb5-1 Therapeutic array transducer element using coresonance between hemispherical piezoceramic shell and water sphere(Poster Session)

Otsu Kenji, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　32　531-532　2011/11/08
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pb5-5 Ultrasonic Monitoring of High Intensity Focused Ultrasound Lesions Using Sub-Image Correlation(Poster Session)

Matsuzawa Ryo, Shishitani Takashi, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　32　539-540　2011/11/08
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pb5-7 Analysis of temperature increase in excised porcine liver tissue induced by cavitation-enhanced HIFU(Poster Session)

Iwasaki Eiko, Asai Ayumu, Moriyama Tatsuya, Shishitani Takashi, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　32　543-544　2011/11/08
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pb5-8 Efficient Generation of Cavitation Cloud by Dual-Frequency Ultrasound Exposure(Poster Session)

Yasuda Jun, Takagi Ryo, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　32　545-546　2011/11/08
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3Pb5-4 3D-Quantitative Optical Measurement of Asymmetrically Focused Ultrasound Pressure Field(Poster Session)

Shimazaki Yuta, Harigane Soichiro, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　32　537-538　2011/11/08
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
キャビテーション気泡による加熱増強効果を利用した超音波治療

吉澤晋

超音波テクノ　23　(5)　91-95　2011/10
マイクロバブルの応用

S. Yoshizawa, Yoichiro Matsumoto

Journal of Clinical and Experimental Medicine　238　(2)　157-162　2011/07/09
Publisher: 医歯薬出版
ISSN： 0039-2359
マイクロ気泡による集束超音波治療の効率化

梅村晋一郎, 吉澤晋, 稲葉脩太

ナノ医工学年報　5　(1)　111-120　2011
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
新評価科学の構築:疾患伴侶動物を対象とした新規治療機器の評価手法開発

村垣善浩, 村垣善浩, 伊関洋, 伊関洋, 鈴木孝司, 吉光喜太郎, 石井宏志, 和田章秀, 岡本芳晴, 仲本秀和, 阿部信隆, 川畑健一, 梅村晋一郎, 吉澤晋

日本生体医工学会大会プログラム・論文集(CD−ROM)　50th　ROMBUNNO.OS1-2-3　2011
Effects of Lamb waves in a single-element High Intensity Focused Ultrasound transducer Peer-reviewed

Kenji Otsu, Yasuhiro Kaneshima, Shin Yoshizawa, Shin Ichiro Umemura

AIP Conference Proceedings　1359　211-214　2011

DOI： 10.1063/1.3607907 　

ISSN： 0094-243X

eISSN： 1551-7616
Gel phantom containing controlled air to test Triggered HIFU exposure sequence Peer-reviewed

Kengo Takimoto, Tatsuya Moriyama, Ryo Takagi, Shin Yoshizawa, Shin Ichiro Umemura

AIP Conference Proceedings　1359　109-113　2011

DOI： 10.1063/1.3607891 　

ISSN： 0094-243X

eISSN： 1551-7616
Minimally invasive intracardiac intervention using high intensity focused ultrasound Peer-reviewed

Takashi Mochizuki, Taizou Kihar, Kazunori Itani, Kouji Ogawa, Shin Yoshizawa, Shin Ichiro Umemura, Gontaro Kitazumi, Yasumasa Katsuike, Toshio Chiba

AIP Conference Proceedings　1359　241-245　2011

DOI： 10.1063/1.3607912 　

ISSN： 0094-243X

eISSN： 1551-7616
2P-48 Frequency-Dependent Phase Change threshold of Perfluorocarbon Nanodroplets(Poster Session)

Takimoto Kengo, Moriyama Tatsuya, Yoshizawa Shin, Asami Rei, Kawabata Ken-ichi, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　31　385-386　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P-54 Creation of Multiple Cavitation Clouds by Phased Array Transducer Driven with Staircase Voltage(Poster Session)

Okada Jumpei, Inaba Yuta, Moriyama Tatsuya, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　31　397-398　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P-44 Cavitation Inception by Dual-Frequency Excitation in High Intensity Focused Ultrasound Treatment(Poster Session)

Takagi Ryo, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　31　377-378　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P-46 Study on Change in Sound Speed by HIFU-Exposure in Chicken Breast Muscle(Poster Session)

Shishitani Takashi, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　31　381-382　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P-52 High Speed Observation of Multiple Cavitation Cloud Behavior Induced by HIFU(Poster Session)

Inaba Yuta, Moriyama Tatsuya, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　31　393-394　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
1Pb-60 Analysis of Non-uniform Vibration of Focused Ultrasound Transducer Using Time-Reversal Method(Poster Session)

Komura Yuji, Otsu Kenji, Yoshizawa Shin, Umemura Shin-iciro

Proceedings of Symposium on Ultrasonic Electronics　31　261-262　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
1Pb-15 On the Optical Measurement of Focused Ultrasound Pressure Field(Poster Session)

Omura Ryosuke, Shimazaki Yuta, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　31　171-172　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
1Pb-53 Breathing Mode Ceramic Element for Therapeutic Array Transducer(Poster Session)

Otsu Kenji, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　31　247-248　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
1Pb-63 Effect of thin intervening layer on acoustic impedance measurement of soft tissue using ultrasonic microscope(Poster Session)

Satoh Yusuke, Shishitani Takashi, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　31　267-268　2010/12/06
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
Staircase Voltage MOSFET Driver Circuit for High Intensity Forcused Ultrasound

TAKADA Keisuke, OKADA Jumpei, YOSHIZAWA Shin, UMEMURA Shin-ichiro

IEICE technical report　110　(213)　117-120　2010/09/22
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In ultrasound treatment, an array transducer with a number of elements becomes to be used. Then, we need a class D amplifier which is inexpensive, compact, and low power loss. In square wave drive, odd harmonics are large, so that we designed a class D amplifier which can eliminate the third and fifth harmonics by staircase voltage drive and tested the performance of this amplifier
3D reconstruction of HIFU(high intensity focused ultrasound) pressure field from optical mearuement

SHIMAZAKI Yuta, OMURA Ryosuke, YOSHIZAWA Shin, UMEMURA Shin-itiro

IEICE technical report　110　(213)　13-16　2010/09/22
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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To ensure the safety and accuracy of medical, typically therapeutic, ultrasound an accurate measurement of the ultrasonic field is especially important. The optical ultrasonic field mapping such as a schlieren method has advantages over the measurement with a hydrophone in its orders-of-magnitude faster speed and its non-interference nature to the acoustic field. However, the ultrasonic field obtained by a conventional schlieren method is rather qualitative. By modifying the optical configuration and signal processing, we obtained a pressure field map preserving the sign of the ultrasonic pressure, which is necessary for 3-D reconstruction of the ultrasonic field using a CT algorithm.
Vibration Analysis of Single-element High Intensity Focused Ultrasound Transducer : Effects of Leaky Lamb Waves

OTSU Kenji, KANESHIMA Yasuhiro, KOMURA Yuji, YOSHIZAWA Shin, UMEMURA Shin-ichiro

IEICE technical report　110　(213)　111-116　2010/09/22
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In a spherical single-element piezoceramic transducer for HIFU (High Intensity Focused Ultrasound) treatment, the unwanted modes of plate wave propagation within the ceramic were observed in addition to the pure thickness-mode vibration in experiment. In this study, we analyzed the vibration behavior of a single-element spherical PZT transducer in two ways: by reconstruction of the sound source distribution from the measured ultrasound pressure field and by numerical simulation of vibration based on a Finite Element Method (FEM). In the two-dimensional Fourier analysis, the radial wavenumber spectrum showed a secondary peak, corresponding to waves propagating along the spherical transducer like leaky Lamb waves. The leaked waves propagate in water and form the relatively large lobes on the propagating axis in the nearside of the geometric focus. The acoustic energy of the nearside lobes may cause additional near-field heating of the tissues, which should not be treated.
2P1-G24 Construction Methodology for Non-Invasive Ultrasound Theragnostic System : 2^<nd> report

KOIZUMI Norihiro, SEO Joonho, DEUKHEE Lee, NOMIYA Akira, YOSHINAKA Kiyoshi, YOSHIZAWA Shin, SUGITA Naohiko, HOMMA Yukio, MATSUMOTO Yoichiro, MITSUISHI Mamoru

2010　"2P1-G24(1)"-"2P1-G24(4)"　2010
Publisher: The Japan Society of Mechanical Engineers

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We propose a non-invasive ultrasound theragnostic system that tracks movement in an affected area (kidney stones, in this study) by irradiating it with high-intensity focused ultrasound (HIFU). In this paper, the concept behind a novel medical support system that integrates therapy and diagnostics (theragnostics), is illustrated. The required functions for the proposed system are discussed and an overview of the constructed system configuration is illustrated. Problems of stone motion tracking by ultrasonography are described. To overcome with this problem, we should take 2 approaches. The first approach is to minimize the servoing error to enhance both the efficiency of the therapy and the safety of the patient. The second approach is to reduce the effect of the servoing error. Concerning the first approach, we propose 2 solutions. One is robust detection of the stone position by shape information. Another is the controller that compensates for periodic motion of the affected area. Concerning the second approach, we propse a solution to control HIFU irradiation power in accordance with the servoing error, mainly to enhance the safety of the patient.
マイクロ気泡による集束超音波治療の加速 : 相変化ナノ液滴やキャビテーションの応用

梅村晋一郎, 吉澤晋

ナノ医工学年報　4　(1)　109-118　2010
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
Effects of lamb wave in therapeutic ultrasound transducer by vibration analysis Peer-reviewed

Kenji Otsu, Yasuhiro Kaneshima, Shin Yoshizawa, Shin Ichiro Umemura

IFMBE Proceedings　31 IFMBE　1640-1643　2010

DOI： 10.1007/978-3-642-14515-5_417 　

ISSN： 1680-0737
Acoustic impedance evaluation of thermally denatured and non-denatured biological tissues Peer-reviewed

T. Shishitani, S. Yoshizawa, S. Umemura

IFMBE Proceedings　31 IFMBE　1629-1632　2010

DOI： 10.1007/978-3-642-14515-5_414 　

ISSN： 1680-0737
3J5-2 Vibration Analysis of High Intensity Focused Ultrasound Source using Time Reversal : Effects of Lamb Waves(Medical Acoustics)

Kaneshima Yasuhiro, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　30　403-404　2009/11/18
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236

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In HIFU (High Intensity Focused Ultrasound) therapy, ultrasound is focused on target tissue for coagulation. This method is attracting attention as noninvasive therapeutic modality, and being researched widely from basic study to clinical application. Accurate measurement of the ultrasound pressure field is very important in the research areas of HIFU such as biological effects and ultrasound devices. In this study, we reconstructed the distribution of sound source vibration using Time Reversal and investigated the effects of Lamb waves. In the two-dimensional Fourier transform of the sound source vibration in both time and space domain, we found a peak with a finite phase velocity, which may corresponds to Lamb waves propagating from the edge toward the center of the circular transducer.
2P5-7 Staircase Voltage MOSFET Driver Circuit for Therapeutic Ultrasound(Poster Session)

Moro Kosuke, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　30　333-334　2009/11/18
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
2P5-8 Vibration Analysis of Therapeutic Ultrasound Transducer by FEM(Poster Session)

Otsu Kenji, Yoshizawa Shin, Azuma Takashi, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　30　335-336　2009/11/18
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3P5-20 Acoustic Impedance Evaluation of Thermally-induced Lesion in Biological Tissue using Ultrasonic Microscopy(Poster Session)

Shishitani Takashi, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　30　561-562　2009/11/18
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3P5-17 Enhancement of Localized Heating by Ultrasonically Induced Cavitation in High Intensity Focused Ultrasound Treatment(Poster Session)

Takagi Ryo, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　30　555-556　2009/11/18
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
3P5-18 Coagulation of Large Region by Creating Multiple Cavitation Clouds for HIFU Treatment(Poster Session)

Inaba Yuta, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　30　557-558　2009/11/18
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
1P2-16 Analysis of Therapeutic Ultrasound Pressure Field with Schlieren Optical System(Poster Session)

Omura Ryosuke, Yoshizawa Shin, Umemura Shin-ichiro

Proceedings of Symposium on Ultrasonic Electronics　30　47-48　2009/11/18
Publisher: Steering committee of symposium on ultrasonic electronics
ISSN： 1348-8236
医工連携の実践治療機器開発のための疾患伴侶動物の試験研究動物実験とヒト治験の橋渡し

村垣善浩, 伊関洋, 鈴木孝司, 吉光喜太郎, 石井宏志, 和田章秀, 岡本芳晴, 佐々木明, 仲本秀和, 阿部信孝, 荒井修, 川畑健一, 梅村晋一郎, 吉澤晋

日本コンピュータ外科学会誌　11　(3)　153-154　2009/11
Publisher: (一社)日本コンピュータ外科学会
ISSN： 1344-9486

eISSN： 1884-5770
Servoing Performance and safety enhancement for the Non-Invasive Ultrasound Theragnostic System

小泉憲裕, SEO Joonho, 鈴木悠悟, 野宮明, 吉澤晋, 葭仲潔, 杉田直彦, 本間之夫, 松本洋一郎, 光石衛

日本ロボット学会学術講演会予稿集(CD-ROM)　27th　2009
ナノまたはマイクロ粒子による集束超音波治療効果の強調

梅村晋一郎, 吉澤晋

ナノ医工学年報　3　(1)　113-122　2009
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
超音波キャビテーションとその治療応用

吉澤晋, 梅村晋一郎, 松本洋一郎

マテリアルインテグレーション　22　(6)　48-53　2009
Publisher: ティー・アイ・シィー
ISSN： 1344-7858
Development of HIFU treatment in which the heating location is controlled using microbubbles Peer-reviewed

Kenichi Kajiyama, Naoyuki Iida, Keisuke Hasegawa, Shin Yoshizawa, Kiyoshi Yoshinaka, Shu Takagi, Yoichiro Matsumoto

AIP Conference Proceedings　1113　48-52　2009

DOI： 10.1063/1.3131469 　

ISSN： 0094-243X

eISSN： 1551-7616
1A1-C11 Construction Methodology for Non-Invasive Ultrasound Theragnostic System

KOIZUMI Norihiro, LEE Deukhee, OTA Kohei, OTA Ryuhei, YOSHIZAWA Shin, YOSHINAKA Kiyoshi, MATSUMOTO Yoichiro, MITSUISHI Mamoru

2008　"1A1-C11(1)"-"1A1-C11(4)"　2008/06/06
Publisher: The Japan Society of Mechanical Engineers

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The authors have developed a non-invasive ultrasound theragnostic system to decrease the strain of patients and medical doctors. The system we propose tracks and follows movement in an affected area -kidney stones here- while High-Intensity Focused Ultrasound (HIFU) is irradiated onto the area. In this paper, a framework of the non-invasive ultrasound theragnostic system is proposed and illustrated. Specifically, the concept of the system is proposed at first. Secondly, decomposing and reconstructing (structuring) of the functional requirements are discussed. Third, the constructed system, which is based on those structured functional requirements, is illustrated. Fourth, the result of the servoing experiments of the model stone is reported to confirm the effectiveness of the proposed construction methodology and constructed system.
Nonlinear phenomena of acoustic cloud cavitation Peer-reviewed

Yoichiro Matsumoto, Shin Yoshizawa, Shu Takagi

AIP Conference Proceedings　1022　237-240　2008

DOI： 10.1063/1.2956196 　

ISSN： 0094-243X

eISSN： 1551-7616
Framework of the non-invasive ultrasound theragnostic system Peer-reviewed

Norihiro Koizumi, Deukhee Lee, Kohei Ota, Shin Yoshizawa, Kiyoshi Yoshinaka, Yoichiro Matsumoto, Mamoru Mitsuishi

MEDICAL IMAGING AND AUGMENTED REALITY, PROCEEDINGS　5128　231-240　2008

DOI： 10.1007/978-3-540-79982-5_26 　

ISSN： 0302-9743

eISSN： 1611-3349
High Intensity Focused Ultrasound Therapy with Microbubbles

S. Yoshizawa, S. Umemura, Y. Matsumoto

11th International Symposium on Advanced Biomedical Ultrasound　2008
1P1-H06 Feedforward control utilizing real-time information of the integrated system for non invasive ultrasound diagnosis and treatment

KOIZUMI Norihiro, OTA Kohei, LEE Deukhee, YOSHIZAWA Shin, ITOH Akira, MATSUMOTO Yoichiro, MITSUISHI Mamoru

2007　"1P1-H06(1)"-"1P1-H06(2)"　2007/05/11
Publisher: The Japan Society of Mechanical Engineers

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The authors have developed an integrated system for the non-invasive ultrasound diagnosis and treatment to decrease the load of patients and medical doctors. In this paper, motion of a kidney and abdominal circumference information, which is acquired by a force sensor, are analyzsed at first. Secondly, the authors propose a feedforward controller to enhance the servoing performance of the system for model kidney stones by utilizing real-time information of abdominal circumference. Finally, experimental results show that the constructed system ia appropriate to presume the phase information of stone motion to generate the feedforward term of the controller.
1P1-H05 Kidney Stone Tracking Framework Using Ultrasonic Radio Frequency Echo Signal

LEE Deukhee, KOIZUMI Norihiro, OTA Kohei, YOSHIZAWA Shin, ITOH Akira, MATSUMOTO Yoichiro, MITSUISHI Mamoru

2007　"1P1-H05(1)"-"1P1-H05(3)"　2007/05/11
Publisher: The Japan Society of Mechanical Engineers

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The authors are developing an ultrasound-based integrated system for non-invasive diagnosis and treatment of kidney stones. The major goals of the system are to aid to detect kidney stones with ultrasound images and to eliminate them by cloud-cavitaion controlled lithotripsy using high intensity focused ultrasound (HIFU). The target kidney stone of lithotripsy moves during the treatment by breathing. Therefore, real-time motion tracking and servoing of the target kidney stone are necessary in order to improve the accuracy of the treatment and reduce treatment time. This paper describes the feasibility study of real-time 3D tracking and servoing with two ultrasound diagnostic probes and a 3D stage machine using ultrasonic radio frequency (RF) echo signal with regard to the therapeutic goal of the integrated system.
Optimization of Ultrasound Lithotripsy by Ultrasound Monitoring

OHTA Ryuhei, ITO Akira, YOSHIZAWA Shin, TAKAGI Shu, MATSUMOTO Yoichiro

34　S306　2007/04/15

ISSN： 1346-1176
非侵襲超音波診断・治療統合システムにおけるフィード・フォワード制御

小泉憲裕, 太田耕平, LEE Deukhee, 吉澤晋, 伊藤陽, 松本洋一郎, 光石衛

精密工学会大会学術講演会講演論文集　2007　2007
非侵襲超音波診断・治療統合システムのためのリアルタイム呼吸情報取得

太田耕平, 小泉憲裕, LEE Deukhee, 吉澤晋, 伊藤陽, 松本洋一郎, 光石衛

精密工学会大会学術講演会講演論文集　2007　2007
10項超音波エレクトロニクス研究会(3節工学研究会,第5章国際会議・シンポジウム等)

梅村晋一郎, 吉澤晋

東北大学電気通信研究所研究活動報告　14　300-301　2007/01/01
Behavior of microbubbles in an ultrasound field and medical applications using microbubbles

S. Yoshizawa, Y. Matsumoto

Valve technical report　22　(1)　62-66　2007
Real-time imaging of the process of stone crushing by ultrasound Peer-reviewed

Akira Ito, Shin Yoshizawa, Yukio Kaneko, Haruki Kume, Tadaichi Kitamura, Yoichiro Matsumoto

AIP Conference Proceedings　911　342-348　2007

DOI： 10.1063/1.2744295 　

ISSN： 0094-243X

eISSN： 1551-7616
Numerical Study on Rectified Diffusion of an Oscillating Microbubble in an Ultrasound Field Peer-reviewed

S. Yoshizawa, Y. Matsumoto

Proc. of The 1st International Colloquium on Dynamics, Physics and Chemistry of Bubble and Gas-Liquid Boundaries　2007
Development of an integrated system for non-invasive ultrasound diagnosis and treatment

OTA K., KOIZUMI N., LEE D., YOSHIZAWA S., ITO A., MATSUMOTO Y., MITSUISHI M.

8　(3)　386-387　2006/12/30

ISSN： 1344-9486
AM06-KN-004 Medical Applications in Fluid Mechanics : Noninvasive Therapeutic Ultrasound with Microbubbles

Matsumoto,Yoichiro, Fujiwara,Akiko, Yoshizawa,Shin, Kaneko,Yukio

Proceedings, ... meeting of Japan Society of Fluid Mechanics　2006　(0)　17-20　2006/09
Publisher: Japan Society of Fluid Mechanics
ISSN： 1342-8004

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Ultrasonic medical applications such as ultrasound diagnosis and High Intensity Focused Ultrasound (HIFU) therapy have recently been the subject of much interest. In these applications, micro-bubbles facilitate the medical treatment by improving the image quality or enhancing the therapeutic effects through localized heating or acoustic emission. In order to treat a diseased part properly and safely, real-time diagnosis with therapy is necessary. The objective of this study is the establishment of the integrative system of real-time ultrasound imaging and minimally invasive HIFU therapy.
Ultrasound Imaging for the Diagnostic and Therapeutic System

YOSHIZAWA Shin, KANEKO Yukio, FUJIWARA Akiko, MATSUMOTO Yoichiro

Journal of the Visualization Society of Japan　26　(1)　5-8　2006/07/01
Publisher: 可視化情報学会
ISSN： 0916-4731
Characterization of the HIFU-induced cloud cavitation for the optimization of high pressure concentration for lithotripsy Peer-reviewed

Teiichiro Ikeda, Shin Yoshizawa, Yukio Kaneko, Yoichiro Matsumoto

AIP Conference Proceedings　829　328-332　2006/05/08

DOI： 10.1063/1.2205491 　

ISSN： 0094-243X

eISSN： 1551-7616
21101 Real-time Ultrasound Imaging of Process of Ablation Induced by HIFU

ITO Akira, KANEKO Yukio, YOSHIZAWA Shin, TAKAGI Shu, MATSUMOTO Yoichiro

2006　(12)　89-90　2006/03/09
Publisher: The Japan Society of Mechanical Engineers

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It is necessary to accurately understand the condition of the treated region from outside of the body in real-time in HIFU (High Intensity Focused Ultrasound) therapy. In this study, to monitor the condition of the treated region with ultrasound diagnostic system, the ultrasound diagnostic images were compared with the movie taken by a digital video camera during and after ultrasound irradiation. In the ultrasound diagnostic images, high-bright region got shrunk after the irradiation stopped, but not in the video images. This probably means cavitation bubbles disappeared after the irradiation. This result indicates the necessity for the consideration of cavitaion effect on ultrasound diagnostic images in monitoring HIFU therapy.
Design of Controller and its Servoing Performance of the Integrated System for Non-Invasive Ultrasound Diagnosis and Treatment

小泉憲裕, 太田耕平, LEE Deukhee, 吉澤晋, 伊藤陽, 中島義和, 松本洋一郎, 光石衛

日本ロボット学会学術講演会予稿集(CD-ROM)　24th　2006
3638 Simulation of Temperature Rise during High Intensity Focused Ultrasound Therapy

KATO Mitsuaki, YOSHIZAWA Shin, ONO Kenji, MATSUMOTO Yoichiro

The Proceedings of Mechanical Engineering Congress, Japan　2006　(0)　369-370　2006
Publisher: 一般社団法人日本機械学会
DOI： 10.1299/jsmemecjo.2006.2.0_369 　

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Focused ultrasound treatment is widely applied in the clinical treatment, for example the tumor ablation with High Intensity Focused Ultrasound (HIFU). HIFU shows considerable nonlinearity due to its high pressure amplitude, and it is attenuated, reflected and refracted in the medium. Previously, researchers have simulated the ultrasound field using linear and nonlinear approximation equations. However, the predictions using these equations have restrictions such that the higher order nonlinearity or the reflection and refraction cannot be reproduced. So we apply axsymmetric Navier-Stokes equation to the governing equation to solve the ultrasound propagation without such restrictions. We calculated the profile of temperature rise in a liver with the model of an array transducer and an absorption effect. It is concluded that the temperature rise is focused at focal point by modeling array transducer and the ratio of the parameters inside the absorption coefficient affects the temperature rise and distribution.
2A1-A18 The development of the integrated system for non invasive ultrasound diagnosis and treatment (1st report) : The controller and experiment for servoing stone model in the bladder

OTA Kohei, KOIZUMI Norihiro, YOSHIZAWA Shin, ITOH Akira, NAKAJIMA Yoshikazu, WARISAWA Shin'ichi, MATSUMOTO Yoichiro, MITSUISHI Mamoru

The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)　2006　(0)　_2A1-A18_1-_2A1-A18_3　2006
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmermd.2006._2A1-A18_1 　

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In this paper, the authors report the required functions of the integrated system for non invasive ultrasound diagnosis and treatment and the methods of mounting these functions. The concept of the proposed system is to destroy cancer tissues and stones by applying high intensity focused ultrasound (HIFU) to the affected parts precisely without destroying peritumoral tissues. But if the affected parts lie in the deep portion of the patient's body, it is difficult to apply HIFU precisely by reason of the movement of the affected parts with the influence of breath. Therefore the authors propose the system which has the function of canceling the influence of the movement.
Medical applications in fluid mechanics (noninvasive therapeutic ultrasound with microbubbles)

Y. Matsumoto, A. Fujiwara, S. Yoshizawa, Y. Kaneko

Nagare　25　(6)　533-541　2006
Publisher: Japan Society of Fluid Mechanics
DOI： 10.11426/nagare1982.25.533 　

ISSN： 0286-3154
Numerical study on growth by rectified diffusion of an oscillating bubble in an ultrasound field Peer-reviewed

S. Yoshizawa, Y. Matsumoto

Proc. of 6th International Symposium on Cavitation　2006
Optimization of the bubble cloud collapse with application to lithotripsy Peer-reviewed

T. Ikeda, S. Yoshizawa, Y. Matsumoto

Proc. of 6th International Symposium on Cavitation　2006
The design of microbubbles specialized for therapeutic or diagnostic use Peer-reviewed

Yukio Kaneko, Shunsuke Watanabe, Shin Yoshizawa, Shu Takagi, Yoichiro Matsumoto

AIP Conference Proceedings　754　224-226　2005/03/28

DOI： 10.1063/1.1901643 　

ISSN： 0094-243X

eISSN： 1551-7616
High-speed observation of two-frequency controlled cloud cavitation in HIFU field Peer-reviewed

Teiichiro Ikeda, Masataka Tosaki, Shin Yoshizawa, Yoichiro Matsumoto

AIP Conference Proceedings　754　199-203　2005/03/28

DOI： 10.1063/1.1901636 　

ISSN： 0094-243X

eISSN： 1551-7616
Numerical study of the heat transfer from an oscillating bubble Peer-reviewed

Shin Yoshizawa, John S. Allen, Shu Takagi, Yoichiro Matsumoto

AIP Conference Proceedings　754　131-133　2005/03/28

DOI： 10.1063/1.1901618 　

ISSN： 0094-243X

eISSN： 1551-7616
Nonlinear acoustic behavior of a microbubble in an oscillating pressure field

S. Yoshizawa, Y. Matsumoto

Nagare　24　(4)　405-412　2005
Publisher: Japan Society of Fluid Mechanics
DOI： 10.11426/nagare1982.24.405 　

ISSN： 0286-3154
Dynamics of bubble and bubble cloud

Y. Matsumoto, S. Yoshizawa

Ultrasonic technology　17　(1)　1-6　2005
Using of Focused Ultra-induced Cavitation Erosion for the Industrial Application

TOSAKI Masataka, IKEDA Teiichiro, YOSHIZAWA Shin, TAKAGI Shu, MATSUMOTO Yoichiro

Fluids engineering conference ...　2004　291-291　2004/11/24
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
Simulation of ultrasound propagation in body

IMAKITA Akio, ONO Kenji, YOSHIZAWA Shin, MATSUMOTO Yoichiro

Fluids engineering conference ...　2004　277-277　2004/11/24
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
Nonlinear oscillation of ultrasound contrast agents

S. Yoshizawa, Y. Matsumoto

Medical ultrasound - new technology and clinical application　125-129　2004
Ultrasound Focusing in a Spherical Bubble Cloud Peer-reviewed

S. Yoshizawa, T. Ikeda, S. Takagi, Y. Matsumoto

Proc of the 5th International Conference on Multiphase Flow　2004
Ultrasound Focusing in Spherical Bubble Cloud (CAV2003) Peer-reviewed

S. Yoshizawa, Y. Matsumoto

Proc. of Fifth International Symposium on Cavitation　2003
Control of Cavitation in Ultrasound Field

KANEKO Yukio, IKEDA Teiichiro, YOSHIZAWA Shin, TAKAGI Shu, MATSUMOTO Yoichiro

The proceedings of the JSME annual meeting　2002　123-124　2002
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2002.3.0_123 　

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It is known that cavitation erosion cause to break the parts of fluid machinery or damage the tissue of the body during medical ultrasound, for example, ESWL : Extracorporeal Shock Wave Lithotripsy. But if cavitation behavior can be analyzed and controlled actively, we are able to utilize cavitation as a transducer, which can concentrate energy in a very narrow area. And this cavitation control has the possibilities to be applied in engineering and medical field. In order to analyze cavitation behavior in ultrasound field, we conduct experiments and numerically simulate the dynamics of bubble cloud in detail, and we obtain the following conclusions. We build the method to concentrate cavitation cloud only in a small region with high frequency ultrasound and oscillate and crush the cloud with low frequency one near the natural frequency of it. And it is possible to break an object in a narrow area by this method.
Nonlinear oscillation of a bubble

Y. Matsumoto, S. Yoshizawa

Science of machine　54　(1)　108-113　2002
Acoustic Emission from Micro Bubbles in Ultrasound Field Peer-reviewed

S. Yoshizawa, K. Sugiyama, Y. Matsumoto

Proc. of Fourth International Symposium on Cavitation　2001

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Books and Other Publications 4

Ultrasonics : physics and applications

Matsukawa, Mami

IOP Pub.　2022

ISBN: 9780750349345
スマート医療テクノロジー

エヌ・ティー・エス　2019/10

ISBN: 9784860436193
微細気泡の最新技術Vol.2 ～進展するマイクロ・ナノバブルの基礎研究と拡がる産業利用～

エヌ・ティー・エス　2014/08

ISBN: 9784860434076
マイクロバブル最前線

松本洋一郎, 高木周, 吉澤晋, 金子暁子, 竹村文男, 村井祐一, 川村隆文, 児玉良明, 幸田和郎, 井田博之, 川崎達治, 金子幸生

共立出版　2009

ISBN: 9784320081673

Presentations 14

Enhancement of cavitation inception by second-harmonic superimposition International-presentation

S. Yoshizawa, R. Takagi, J. Yasuda, S. Umemura

19th International Symposium on Nonlinear Acoustics　2012/05/21
High-intensity focused ultrasound heating of large tissue region enhanced by cavitation bubbles at multiple focal spots

S. Yoshizawa, K. Nakamura, A. Asai, J. Yasuda, S. Umemura

Acoustics 2012　2012/05/13
Ultrasound Tissue Heating Enhanced by Cavitation Clouds at Multiple Focal Spots for High-intensity Focused Ultrasound Therapy International-presentation

S. Yoshizawa, T. Moriyama, E. Iwasaki, K. Nakamura, A. Asai, S. Umemura

6th International Symposium on Medical, Bio- and Nano-Electronics　2012/03/08
Cavitation Inception and Growth by Dual-Frequency Excitation in High-Intensity Focused Ultrasound Treatment International-presentation

S. Yoshizawa, J. Yasuda, S. Umemura

2011 IEEE International Ultrasonics Symposium　2011/10/18
Cavitation Inception and Growth by Dual-Frequency Excitation Method International-presentation

S. Yoshizawa, R. Takagi, J. Yasuda, S. Umemura

11th International Symposium on Therapeutic Ultrasound　2011/04/11
Large-volume coagulation by creating multiple cavitation clouds in High Intensity Focused Ultrasound treatment International-presentation

S. Yoshizawa, Y. Inaba, R. Takagi, S. Umemura, Y. Muragaki, H. Iseki

Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST) International Symposium　2011/01/17
3D reconstruction of ultrasonic fields from optical measurement International-presentation

R. Omura, Y. Shimazaki, ○S. Yoshizawa, S. Umemura

2010 IEEE International Ultrasonics Symposium　2010/10/11
Ultrasound lithotripsy for pet kidney stones International-presentation

S. Yoshizawa, K. Iida, A. Wada, T. Matsuura, H. Ishii, S. Umemura, Y. Matsumoto

10th International Symposium on Therapeutic Ultrasound　2010/06/09
Enhancement of Localized Heating by Creating Multiple Cavitation Clouds International-presentation

S. Yoshizawa, Y. Inaba, R. Takagi, S. Umemura

10th International Symposium on Therapeutic Ultrasound　2010/06/09
Tissue ablation using cavitating bubbles triggered by high intensity ultrasound pulse International-presentation

S. Yoshizawa, R. Takagi, S. Umemura

9th International Symposium on Therapeutic Ultrasound　2009/09/23
Cavitation Detection with Subharmonic Emissions by Low Intensity Sustaining Ultrasound International-presentation

S. Yoshizawa, S. Umemura, Y. Matsumoto

2008 IEEE International Ultrasonics Symposium　2008/11/02
Ultrasound Heating Enhanced with Acoustic Cavitation Induced by Pulsed Ultrasound International-presentation

S. Yoshizawa, S. Umemura, Y. Matsumoto

8th International Symposium on Therapeutic Ultrasound　2008/09/10
High Intensity Focused Ultrasound Therapy with Microbubbles International-presentation

S. Yoshizawa, S. Umemura, Y. Matsumoto

11th International Symposium on Advanced Biomedical Ultrasound　2008/03/07
Numerical Study on Rectified Diffusion of an Oscillating Microbubble in an Ultrasound Field International-presentation

S. Yoshizawa, Y. Matsumoto

1st International Colloquium on Dynamics, Physics and Chemistry of Bubble and Gas-Liquid Boundaries　2007/09/25

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Industrial Property Rights 15

超音波医用装置

吉澤晋, 高木亮, 梅村晋一郎, 玉野聡

特許6633314

Property Type: Patent
光音響計測装置

長岡亮, 西條芳文, 梅村晋一郎, 吉澤晋

Property Type: Patent
超音波医用システム

吉澤晋, 高木亮, 梅村晋一郎, 玉野聡

Property Type: Patent
超音波の送信回路

梅村晋一郎, 吉澤晋, 神保勇人, 玉野聡

Property Type: Patent
アレイ型超音波送波器

梅村晋一郎, 吉澤晋, 大津賢治

Property Type: Patent
アレイ型超音波送波器

梅村晋一郎, 吉澤晋, 大津賢治

特許第5605567号

Property Type: Patent
超音波洗浄方法

正木広志, 妻木伸夫, 佐原輝隆, 北田由光, 松本洋一郎, 吉澤晋

Property Type: Patent
超音波洗浄方法

正木広志, 妻木伸夫, 佐原輝隆, 北田由光, 松本洋一郎, 吉澤晋

特許第5127257号

Property Type: Patent
超音波洗浄装置

松本洋一郎, 池田貞一郎, 吉澤晋, 佐原輝隆, 妻木伸夫, 北田由光

Property Type: Patent
超音波洗浄装置

松本洋一郎, 池田貞一郎, 吉澤晋, 佐原輝隆, 妻木伸夫, 北田由光

特許第4442383号

Property Type: Patent
超音波照射方法及び超音波照射装置

松本洋一郎, 池田貞一郎, 吉澤晋

Property Type: Patent
超音波照射方法及び超音波照射装置

吉澤晋, 松本洋一郎, 池田貞一郎

Property Type: Patent
超音波照射方法及び超音波照射装置

吉澤晋, 松本洋一郎, 池田貞一郎

特許第4139916号

Property Type: Patent
微小可動機構システムと微小可動機構部の制御方法

柳田美穂, 吉澤晋

Property Type: Patent
微小可動機構システムと微小可動機構部の制御方法

柳田美穂, 吉澤晋

特許第3800161号

Property Type: Patent

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Research Projects 15

Ultrasonic signed echo imaging to distinguish bwtween vulnerable and stable plaques

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2021/04/01 - 2024/03/31
リピッドバブルとMRIガイド経頭蓋超音波による血液脳関門開口と脳内薬物送達

丸山一雄, 吉田道春, 梅村晋一郎, 吉澤晋, 小俣大樹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 帝京大学

2020/04/01 - 2023/03/31

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脳には血液と脳実質の間の物質移行を厳密に制御する血液脳関門が存在する。脳腫瘍やアルツハイマー病などの中枢神経系疾患に対する薬物治療において、血液脳関門が障壁となる。そのため、脳実質へと薬物送達可能な技術が求められている。近年、集束超音波とマイクロバブルを利用した血液脳関門の透過性亢進技術が注目されている。超音波照射によりマイクロバブルの収縮や膨張といった機械的作用が誘導され、血管内皮細胞間の密着結合が緩まり、血管透過性が亢進すると考えられている。そのため、マイクロバブルの収縮や膨張などの振る舞いに影響する超音波の周波数と音圧は、血液脳関門の透過性亢進において重要なパラメーターである。そこで本研究では、効率的かつ低侵襲的な血液脳関門の透過性亢進を行うために、脳への薬物送達と傷害性に及ぼす集束超音波の周波数と音圧の影響を検討した。マウスにリピッドバブルとモデル薬物としてエバンスブルーを静脈内投与し、脳に集束超音波 (周波数：0.25, 0.5, 1.0 MHz、音圧：0.1, 0.2, 0.4, 0.6 MPa) を照射した。1時間後に血液還流し、脳実質へのエバンスブルー移行を評価した。その結果、0.25 MHz、0.5 MHzの各音圧および1 MHzの0.6 MPaでは脳の広範囲において脳の広範囲においてエバンスブルーの漏出が認められた。一方で、1 MHzの0.4 MPaでは超音波集束部位でエバンスブルーの漏出が認められた。次に、各周波数において、エバンスブルー漏出が認められた最低音圧を用いて、血液脳関門の透過性亢進を誘導し、脳切片のヘマトキシリン・エオジン染色により傷害性を評価した。その結果、0.25 MHzと0.5 MHzでは赤血球の漏出が認められたに対して、1 MHzの0.4 MPaでは赤血球の漏出は認められなかった。これらの結果から、1 MHz、0.4 MPaの集束超音波照射条件を用いることで、標的部位に対して低侵襲的かつ効率的な血液脳関門オープニングを誘導できることが示唆された。
音響力学的療法における治療効果増強薬剤の探索的研究

岡本淳, 吉澤晋, 村垣善浩

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東京女子医科大学

2020/04/01 - 2023/03/31

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本提案では音響力学的療法（sonodynamic therapy：SDT）において抗腫瘍効果増大作用を示す薬剤の網羅的な探索研究を行う。SDTは高密度集束超音波（high-intensity focused ultrasound: HIFU）と薬剤の相互作用を利用する方法であり、体内深部の低侵襲がん治療を目的としている。我々は既にDDS製剤（エピルビシンナノミセル）を用いたSDTの疾患動物治療や人に対する臨床研究を行っているが、SDTの作用機序自体は明らかでない部分が多い。本研究では難治性がんの代表である膵がん等で適用されている抗がん剤を中心に選定した薬剤に対し、HIFUとの相互作用によるマウスに対する腫瘍増殖抑制効果検証実験を行い、がんに対して有効な薬剤のスクリーニングを行うとともに、結果から推測される作用機序について考察を行い、SDTの効果に関する科学的な説明を試みる。本年度は効果的にキャビテーションをエンハンス可能なマルチチャンネルトランスデューサを開発し、性能評価試験を実施した。加熱波、トリガー波の焦点サイズと焦点位置、サイドローブの大きさを精密に測定し、また、天秤法により音響出力も正確に測定を行った。さらに焦点温度の計測も行い、細胞に対するサーマルドーズとの関係を導き、細胞への影響を定量化した。来年度以降、本トランスデューサを用い、マウス等を用いたSDT実験を実施していく。
Development of Ultrasound Lithotripsy with High Throughput and Accuracy using Acoustic Cavitation

YOSHIZAWA Shin

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2016/04 - 2020/03

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A HIFU transducer which has two resonance frequencies was developed. Cavitation bubbles were generated by the newly developed transducer or existing transducers and observed by high-speed photography and ultrasound imaging to investigate the behavior of the cavitation bubbles. A HIFU exposure method was proposed to erode a renal stone using cavitation bubbles efficiently. The result in the experiment of the erosion of model stones in a water tank showed the efficiency of the proposed method.
Hemi-sperical ultrasonic trasducer producing high power at low voltage

Umemura Shin-ichiro, ITO HIROSHI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2016/04/01 - 2019/03/31

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A short ultrasonic pulse at an extremely high pressure is effective to generate acoustic cavitation, which remarkably enhances the efficiency of ultrasonic therapy and lithotripsy. However, if it is for a conventional thickness mode piezoelectric transducer, the required driving voltage may almost exceed the limit of MOSFETs. To overcome this problem, we have suggested a spherical transducer utilizing the co-resonance between a piezoelectric spherical shell and a water sphere. We are further suggesting a cylindrical transducer utilizing the co-resonance between a piezoelectric cylindrical shell and a water cylinder. Its principle was confirmed by a numerical simulation, and a prototype transducer was constructed, which proved that the ratio of acoustic output / driving voltage was in a realistic range.
High-speed Measurement of 3D Ultrasound Field Reconstructed from Shadowgraph Images

YOSHIZAWA Shin

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2016/04/01 - 2019/03/31

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An experimental system for the measurement of a 3D ultrasound field reconstructed from optical images was developed. The optical images of a 3D focused ultrasound field were obtained and the pressure field was successfully reconstructed. A simulation code was developed to estimate optical phase modulations by acoustic field from shadowgraph images. The error of the reconstructed pressure when the distance between the acoustic field and the optical measurement plane was relatively long was reduced by the simulation. Furthermore, a 3D ultrasound field was reconstructed using the combination of the optical measurement and numerical simulation where the nonlinearity of ultrasound propagation is considered. The measurement time for a 3D nonlinear ultrasound field was significantly reduced by the combined method.
Development of photoacoustic flow cytometry by employing multi-channel high frequency ultrasonic probe

Nagaoka Ryo, SAIJO Yoshifumi, UMEMURA Shin-ichiro, YOSHIZAWA Shin, ARAKAWA Mototaka, ISHIKAWA Kazuo

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up

Category: Grant-in-Aid for Research Activity start-up

2016/08/26 - 2018/03/31

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In a traditional photoacoustic flow cytometry, cells in vessels are aligned in one line by laser manipulation, and the photoacoustic signals induced from the cells are measured to classify the characteristics. However, scattering and absorption in the living tissues has effects on the propagation of the radiated laser, and the alignment of the cell by the manipulation cannot be achieved owing to the effect. In this study, the effect of the scattering and absorption was minimized by acoustical focusing, and the method could visualize the living tissues at the deeper part was developed.
Real-time detection of HIFU (high-intensity focused ultrasound) induced thermal coaulation by ultrasonic imaging

Umemura Shin-ichiro, YOSHIZAWA SHIN

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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In noninvasive therapy such as HIFU (high-intensity focused ultrasound) treatment, a noninvasive imaging method to aim and monitor the tissue to be treated is essential because the surgeon cannot looked at the tissue by naked eye. Ultrasonic imaging has advantages that the deflection due to non-uniformity in sound speed can be inherently corrected and that real-time imaging can achieved at a relatively low cost, but temperature mapping is significantly more difficult than MRI in principle. Therefore, we looked at the fact that the correlation between ultrasonic echo images before and after thermal coagulation significantly decreases because of the change in backscatter of the tissue. As the result of this study, we succeeded in real-time detection of HIFU-induced thermal coagulation of tissue by real-time mapping of maximum correlation coefficient between the ultrasonic RF images obtained using high-speed ultrasonic imaging.
Treatment Time Reduction in Ultrasound Thermal Therapy using Cavitation Bubbles in a Large Region

YOSHIZAWA Shin, UMEMURA Shin-ichiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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High-intensity focused ultrasound has attracted much attention as a modality for the noninvasive thermal treatment of cancer. However, it has a problem of long treatment time. The objective of this study is to develop a method for the ultrasonic heating with high efficiency by using cavitation clouds generated in a large region. Cavitation clouds were generated and used in a large region by electronically scanning HIFU focus in a plane perpendicular to the HIFU propagation direction. Applying this method to a tissue mimicking phantom, the temperature rise measured with a thermocouple was two to three times of that without cavitation generation. The coagulation volume of chicken breast tissues showed a high efficiency of the developed method for a HIFU thermal treatment.
ACCELERATION OF FOCUSED ULTRASOUND TREATMENT BY HIGH-INTENSITY TRIGGER PULSES

UMEMURA Shinichiro, YOSHIZAWA Shin

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2010 - 2012

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The generation of cavitated microbubbles which can potentially enhance ultrasonic heating of biological tissue was studied using a high-speed camera. An optically transparent gel with tissue-mimicking ultrasonic properties was developed and used. The generation was confirmed at an ultrasonic intensity more than the order of 10 kW/cm2. It was localized in the focal region at a pulse duration less than the order of 100 μs. The throughput of ultrasonic thermal coagulation of excised tissue was markedly improved by the generated microbubbles. Furthermore, it was discovered that the ultrasonic intensity needed for generating such cavitated microbubbles can be significantly reduced by superimposing the second harmonic to the fundamental.
Development of a novel method to enhance localized heating by cavitation bubbles for ultrasound cancer treatment

YOSHIZAWA Shin

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2010 - 2011

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High-intensity focused ultrasound (HIFU)therapy is attracting attention as a noninvasive therapeutic modality for cancer. However, it has a problem of long treatment time. It is known that acoustic cavitation generated in the focal region of HIFU enhances tissue heating. In this study, the behavior of cavitation bubbles were observed and scattered pressure waves from the bubbles were detected and investigated for the cavitation monitoring. The optical pressure measurement method was also investigated.
Development of a method to control acoustic cavitation withdual-frequency ultrasound for therapeutic use

YOSHIZAWA Shin

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2008 - 2009

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Ultrasound treatment has attracted much attention as a treatment for cancer, and many researchers have investigated the method. One of the big topics of the investigation is to control of cavitation bubbles induced by therapeutic ultrasound. In this study, dual-frequency method was investigated to generate cavitation with lower intensity ultrasound and control the cavitation bubbles. The results showed that it is important to choose the frequency and the phase difference of the two-frequency ultrasound depending on the properties of the bubbles.
Noninvasive High Intensity Focused Ultrasound Therapy with Microbubbles Competitive

2007/05 -
集束超音波音場における微小気泡群のマルチ・スケール解析およびその医療応用

吉澤晋

Offer Organization: 日本学術振興会

System: 科学研究費助成事業特別研究員奨励費

Category: 特別研究員奨励費

Institution: 東北大学

2007 - 2007

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本年度の研究においては,強力集束超音波による非侵襲治療を目指して,集束超音波音場における微小気泡および微小気泡群のマルチ・スケール解析を実験・数値計算によって調べた. 医療応用を目的とした実験的な研究としては,動物実験に適用可能な治療システムとして,呼吸による臓器移動を補正しつつキャビテーション気泡群を制御するシステムを構築した.この成果は,「J. Robotics Mechatronics」にて発表された.単一球形気泡の体積振動に関しては,Rectified diffusionによる気泡成長について詳しく調べた.直接数値計算による非線形な挙動と,単純化されたモデルによる結果の比較を行うことで直接数値計算の重要性を調べた.また直接数値計算によって,用いる超音波波形や気泡の大きさについての様々な条件下でRectified diffusionによる気泡成長について調べ,その結果を「1st International Colloquium on Dynamics,Physics and Chemistry of Bubble and Gas-Liquid Boundaries」において発表した.また,単一気泡での解析結果を気泡群の数値解析にフィードバックし,気泡群の数値解析に改良を加えた.その気泡群数値解析コードによる結果の一部を「11th International Symposium on Advanced Biomedical Ultrasound」において発表を行った.
強力集束超音波による非観血的低侵襲治療システムの構築

吉澤晋

Offer Organization: 日本学術振興会

System: 科学研究費助成事業特別研究員奨励費

Category: 特別研究員奨励費

Institution: 東京大学

2004 - 2006

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単一球形気泡の体積振動に関しては,「6th International Symposium on Cavitation」において気泡振動におけるrectified diffusionにつていの発表を行った.ここでは,昨年度に構築したモデルによる計算結果について従来の近似式によって求められる量との比較検討を行ったうえで,異なる2種類の周波数の超音波を重畳させた波形を用いた計算を行い,その波形,圧力振幅とrectified diffusionによるガスの輸送量について詳細な解析を行った.その結果として,周波数重畳波形がガスの輸送を促進させることのできる気泡の大きさについての知見を得た.気泡群の挙動については,昨年度に日本機械学会論文集に掲載されたものをさらに推し進め,波形や気泡のプロパティをパラメータとした計算を行い,それらの結果をまとめて「151^<st> Meeting Acoustic Society of America」において発表を行った.ここでは,マイクロサイズの微小気泡からなる球形気泡クラウドの周波数応答や,気泡クラウドが崩壊するときの気泡の挙動について,昨年度まででわかったことに加えて,波形や気泡のプロパティを変えることによる定量的な影響についての知見が得られるとともに,崩壊挙動の機序や周波数応答の性質については違いがないことがわかった. 実験では,昨年度に行ったブタ膀胱内でのモデル結石の破砕実験の結果を踏まえて,動物実験において体内のキャビテーション発生,成長をモニタリングし,それによってそのときの実験における適切な超音波のパラメータを決定する手法を水槽実験において開発した.また,それまでの超音波結石破砕にかかる成果は「Ultrasound Medicine and Biology」誌に論文が掲載された.

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