Details of the Researcher

PHOTO

Kensuke Sato
Section
Graduate School of Biomedical Engineering
Job title
Degree

  • Ph. D. (Media and Governance) (Keio University)

e-Rad No.
41026265
Profile

連絡先：kensuke.sato.a7「＠」tohoku.ac.jp

Research History 5

  • 2025/04 - Present
    Tohoku University　Graduate School of Biomedical Engineering

  • 2025/03 - 2025/06
    Cincinnati Children's Hospital Medical Center　Center for Stem Cell and Organoid Research and Medicine Division of Gastroenterology, Hepatology and Nutrition　Visiting Scholar

  • 2024/10 - 2025/02
    Showa University

  • 2021/04 - 2024/03
    Keio University

  • 2021/09 - 2023/09
    ヤングリーダー奨学基金奨学生

Education 3

  • Keio University　Graduate School of Media and Governance

    2021/09 - 2025/03

  • Keio University　Graduate School of Media and Governance

    2019/04 - 2021/03

  • Yamagata University　Faculty of Engineering　Department of Bio-system Engineering

    2015/04 - 2019/03

Research Areas 5

  • Life sciences / Applied microbiology /

  • Life sciences / Food sciences /

  • Life sciences / Applied biochemistry /

  • Life sciences / Genomics /

  • Life sciences / Immunology /

Awards 6

  1. 最優秀発表賞

    2023/06　第 27 回腸内細菌学会学術集会

  2. 奨励賞

    2021/03　慶應SFC学会

  3. 第 50 回 リバネス研究費 incu・be 賞 奨励賞

    2020/12　株式会社リバネス

  4. 最優秀プレゼンテーション賞

    2020　慶應義塾大学先端生命研−薬研 合同リトリート「総合システム適塾」

  5. グループワーク第2位

    2016　Keio Spring Science Camp

  6. 第1位

    2016　FDネットワータ“つばさ"プロジェクト 連携主体的学習プログラム 学生主体型授業「合同成果発表コンテスト」

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Papers 6

  1. In vitro inhibition of Escherichia coli β-glucuronidase by aripiprazole Peer-reviewed

    Kohsuke Sugiyama, Kensuke Sato, Hanako Aoki, Maho Kotori, Ryota Nakano, Noriko Hida, Maiko Kusano, Masahiro Akiyama

    Pharmacological Reports　2026/06/04

    DOI： 10.1007/s43440-026-00869-z 　

    ISSN： 1734-1140 2299-5684

    More details Close

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Gut microbial β-glucuronidase (GUS) regulates the deconjugation of glucuronidated compounds, thereby influencing the enterohepatic circulation of xenobiotics and endogenous metabolites. Although many orally administered drugs reach the intestinal lumen, their direct effects on microbial enzyme functions remain incompletely understood. In this study, we systematically examined the impact of ten commonly prescribed central nervous system (CNS)-active drugs on microbial GUS activity.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p> GUS inhibition was evaluated using purified GUS from <jats:italic>Escherichia coli</jats:italic> ( <jats:italic>E. coli</jats:italic> ), <jats:italic>E. coli</jats:italic> cell lysates, and intact bacteria, with p-nitrophenyl β-D-glucuronide as the substrate. Intracellular drug accumulation was quantified by high-performance liquid chromatography-tandem mass spectrometry, bacterial growth was assessed by optical density, and GUS activity in mouse cecal contents was analyzed ex vivo. Molecular docking and molecular dynamics simulations were conducted to characterize drug–GUS interactions. </jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p> Purified GUS screening identified aripiprazole (ARI) and duloxetine hydrochloride (DLX) as inhibitors. In intact E. coli, ARI, but not DLX, suppressed intracellular GUS activity without affecting bacterial growth. ARI also accumulated in <jats:italic>E. coli</jats:italic> at higher levels than DLX. In ex vivo assays, ARI showed inhibitory effects on GUS activity. Computational analyses suggested that ARI and DLX may preferentially interact with distinct regions of GUS, with ARI exhibiting more favorable binding energetics. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p> These findings suggest that specific CNS-active drugs may directly modulate gut microbial GUS activity in <jats:italic>E. coli</jats:italic> under experimental conditions. In particular, ARI inhibited intracellular GUS activity, raising the possibility that certain neuropsychiatric drugs may influence microbial metabolic functions in addition to their canonical pharmacological targets. </jats:p> </jats:sec>

  2. Fasting builds a favorable environment for effective gut microbiota modulation by microbiota-accessible carbohydrates Peer-reviewed

    Kensuke Sato, Ayaka Nakashima, Shinji Fukuda, Joe Inoue, Yun-Gi Kim

    BMC Microbiology　25　(1)　2025/07/05

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12866-025-04140-y 　

    eISSN： 1471-2180

  3. Dietary fermentable polyols fuel gut inflammation through M1 macrophage polarization and gut microbiota Peer-reviewed

    Sato, K., Tomioka, M., Akiyama, M., Matsuda, Y., Hara, H., Sasa, H., Kurashima, Y., Inoue, J., Fukuda, S., Kim, Y.-G.

    Iscience　28　(7)　2025/06

    DOI： 10.1016/j.isci.2025.112934 　

    ISSN： 2589-0042

  4. Sufficient Water Intake Maintains the Gut Microbiota and Immune Homeostasis and Promotes Pathogen Elimination Peer-reviewed

    Kensuke Sato, Mariko Hara-Chikuma, Masato Yasui, Joe Inoue, Yun-Gi Kim

    iScience　2024/05

    DOI： 10.1016/j.isci.2024.109903 　

    ISSN： 2589-0042

  5. Alteration of gene levels in fetal brain by prenatal exposure to methylmercury, copper, and their combination Peer-reviewed

    Kensuke Sato, Ryota Nakano, Yoshitaka Yamazaki, Hikaru Isobe, Yun-Gi Kim, Masahiro Hosonuma, Masahiro Akiyama, Yoshito Kumagai

    Fundamental Toxicological Sciences　11　(3)　131-139　2024

    Publisher: Japanese Society of Toxicology

    DOI： 10.2131/fts.11.131 　

    eISSN： 2189-115X

  6. Complete Genome Sequence of Halomonas hydrothermalis Strain Slthf2, a Halophilic Bacterium Isolated from a Deep-Sea Hydrothermal-Vent Environment Peer-reviewed

    Naota Takeyama, Muyang Huang, Kensuke Sato, Josephine Galipon, Kazuharu Arakawa

    Microbiology Resource Announcements　2020/04/09

    DOI： 10.1128/mra.00294-20 　

    ISSN： 2576-098X

    More details Close

    <jats:p> <jats:named-content content-type="genus-species">Halomonas hydrothermalis</jats:named-content> strain Slthf2 is a Gram-negative bacterium isolated from low-temperature hydrothermal fluids in South Pacific Ocean vent fields located at 2,580-m depth. Here, we report the complete genome sequence of this strain, which has a genome size of 4.12 Mb, with a GC content of 53.2%. </jats:p>

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Misc. 3

  1. Modulation of Gut Microbial Function by Environmental Electrophiles

    今井梨可, 今井梨可, 杉山幸翼, 佐藤謙介, 青木はな子, 青木はな子, 内山純, 内山純, 中野僚太, 草野麻衣子, 秋山雅博

    衛生薬学・環境トキシコロジー講演要旨集　2025　2025

    ISSN： 0919-2115

  2. 腸内細菌の組成や代謝に影響を与えるマイクロバイオームモジュレータ

    謙介 佐藤, 倫基 金

    2023/08/25

    DOI： 10.14952/SEIKAGAKU.2023.950467 　

    ISSN： 0037-1017

  3. Water restriction disputes the gastrointestinal homeostasis

    佐藤謙介, 佐藤謙介, 佐藤謙介, 井上浄, 井上浄, 井上浄, 金倫基

    腸内細菌学雑誌　37　(2)　2023

    ISSN： 1343-0882

Presentations 11

  1. Dietary sorbitol exacerbates experimental colitis by promoting M1 macrophage polarization through gut microbiota

    Kensuke SATO, Yasuyuki MATSUDA, Hideki HARA, Shinji FUKUDA, Yun-Gi KIM

    THE 51st NAITO CONFERENCE ON Microbiome in Health and Disease　2024/06/26

  2. Dietary sorbitol exacerbates experimental colitis by promoting M1 macrophage polarization through gut microbiota

    Kensuke Sato, Yasuyuki Matsuda, Hideki Hara, Shinji Fukuda, Yun-Gi Kim

    Keystone Symposia, Regulation of Barrier Immunity　2024/02

  3. Water restriction disputes the gastrointestinal homeostasis

    The 52nd Annual Meeting of the Japanese Society for Immunology　2024/01/19

  4. Water restriction disputes the gastrointestinal homeostasis

    2023/12

  5. 適切な飲水量は腸管恒常性の維持に重要である

    第27回腸内細菌学会学術集会　2023/06

  6. Fasting and refeeding modulate the antigen-specific immune response and gut microbiota

    Hyper Interdisciplinary Conference in Tokyo 2022　2022/03

  7. 絶食による宿主免疫応答の挙動解析

    第十九回 学術交流大会　2021/03

  8. The effects of fasting on antigen-specific immune response

    The effects of fasting on antigen-specific immune response

    The 10th Hyper Interdisciplinary Conference　2021/03

  9. The effects of fasting on antigen-specific immune response

    The 43rd Annual Meeting of the Molecular Biology Society of Japan,　2020/12

  10. The effects of fasting on antigen-specific immune response

    2020/03

  11. Distribution analysis of small RNA homology sequence in the genome of groups of organisms

    Information Processing Society of Japan Tohoku Branch SIG Technical Report　2019/03

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Research Projects 11

  1. 絶食と腸内細菌利用糖による IgA結合細菌叢の制御法開発に向けて

    佐藤 謙介

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2026/04/01 - 2029/03/31

  2. Elucidating the effects of drinking water restriction on chronic inflammatory and metabolic diseases: a perspective on disruption of intestinal homeostasis.

    Offer Organization: JSPS PD Research Fellowships

    System: JSPS PD Research Fellowships

    Institution: Japan Society for the Promotion of Science

    2025/04 - 2028/03

  3. 絶食が誘導するIgA結合細菌叢の生物学的意義解明と腸内細菌利用糖による制御

    Offer Organization: 公益財団法人 三島海雲記念財団

    System: 学術研究奨励金

    Institution: 東北大学大学院医工学研究科

    2026/08 - 2027/07

  4. The exploration of metabolic responses induced fasting using liver organoids

    Offer Organization: Sylff

    System: Sylff Research Grant

    2024/11 - 2025/10

  5. The analysis of effects of IgA on intestinal bacterial colonization using Record seq.

    System: Overseas Challenge Program for Young Researchers

    2025/03 - 2025/06

  6. Water restriction disputes the gastrointestinal homeostasis

    2023/11 - 2024/10

  7. 絶食と食品成分を用いた腸内細菌叢および免疫応答の制御

    System: JST 博士後期課程学生支援プロジェクト

    2021/10 - 2024/09

  8. 絶食および食品成分を用いた腸内細菌叢，宿主免疫応答の挙動解析

    Offer Organization: Sylff

    System: ヤングリーダー奨学基金

    2022 - 2023

  9. 絶食および食品成分を用いた腸内細菌叢，宿主免疫応答の挙動解析

    Offer Organization: Sylff

    System: ヤングリーダー奨学基金

    2021 - 2022

  10. 絶食および食品成分を用いた腸内細菌叢，宿主免疫応答の挙動解析

    Offer Organization: 株式会社リバネス

    System: リバネス研究費 incu・be 賞 奨励賞

    2020/12 -

  11. 絶食が腸内細菌叢組成及び代謝物にあたえる影響

    Offer Organization: 森泰吉郎記念研究振興基金

    2020 -

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