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Takeshi Kanno

Section

Graduate School of Medicine

Job title

Associate Professor

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/egd

J-GLOBAL ID

201801017707199790

Profile

＜臨床経験に立脚した、社会の問題を解決するエビデンスの構築と、シミュレータ開発および学習法の開発＞

1. 地域医療の経験を背景にし、内科学一般とくに消化器内科学を研究の基盤としています。医学博士は「東日本大震災後の消化性潰瘍の増加とその特徴」に関する臨床研究で取得し、精神的ストレスは、消化性潰瘍の独立した成因であり、災害時潰瘍出血の危険因子となることを報告しました。現在も臨床の課題を克服すべく、コホートを含む臨床研究とCochrane Review memberとしてシステマティックレビューを行っており、エビデンスの実臨床への還元を目指しています。2019年7月よりCochrane Upper GI and Pancreatic diseases(その後Cochrane Gutに名称変更)のEditorとなりました。COVID-19状況下の意思決定支援として、Paul Moayyedi教授の指導下で、免疫不全者や小児におけるワクチン接種の効果に関してのエビデンス集積を行いました。(COVID-END: COVID-19 Evidence Network to support Decision-making in Canada)。

東日本大震災時の出血性潰瘍増加をきっかけとして、出血を伴う観血的内視鏡処置の学習環境の課題を明らかとし、そこから新規シミュレータ開発とそれらを用いた問題解決型シミュレーション教育の推進をしています。
医学教育学会主催の第43回富士研ＷＳにも参加し、医学教育の基本とこれからの在り方に関して学んでおり、2023年4月から自治医科大学医学教育センター医療人キャリア教育開発部門を担当し、卒前卒後をつなぐキャリア教育を模索しています。また2．と関連して災害の経験を通した医療者としてのプロフェッショナリズムに関する講義を継続的に行っております。

＜災害時の経験と人脈をきっかけに、領域横断的な災害医療人材の育成＞
2. 2008年岩手宮城内陸地震(M7.2)では震源地に近接する栗原中央病院での急性期トリアージと初期治療そしてDMAT受け入れを経験しました。また2011年東日本大震災(M9.0)では、南三陸町公立志津川病院で勤務医として15mを超える地震津波災害に被災、患者・住民避難とその後の災害医療体制構築に関わりTIME誌「世界で最も影響力のある100人」に選出されました。以降、災害医療領域の中でこれまで重視されてこなかった支援を受け止める「受援」の在り方を提言しています。さらに、被災した人間として困難に向き合うレジリエントな社会を目指し、国内外で経験と知見を共有する講演活動・いのちの教育を継続しています。2024年現在で講演はのべ250回を超え、2万3千人超の聴講者へメッセージを伝えています。
2019年10月より文部科学省補助金事業（平成30年度選定）「課題解決型高度医療人材養成プログラム」"コンダクター型災害保健医療人材の養成プログラム"の運営業務に携わり、社会に提案できる医療人材育成を進めています。2024年1月の能登半島地震においても自治医科大学同窓会支援チームの立ち上げおよび事務局を担当し受援体制構築と被災地内医療機関の疲弊を防ぐ取り組みを主導しました。

＜クロスアポイントメントを用いた大学×大学連携／臨床×教育連携＞

3. 文部科学省が推進するクロスアポイントメント制度の事例として、2023年4月より東北大学大学院医学系研究科消化器病態学分野でのシミュレータ研究開発を准教授として継続しつつ、自治医科大学医学教育センター医療人キャリア教育開発部門の特命教授として両方常勤職を務め、領域横断的かつ大学横断的な活動を実践すべく取り組んでいます。どちらの所属においても周囲の理解と協力の下でいくつものプロジェクトを進めていますので、研究力や医工連携に強い東北大学と、臨床と医療人教育に強みのある自治医科大学の連携構築としても発展できるよう努めています。

産学連携で開発しているシミュレータ Medical Rising STAR シリーズ（動画）https://www.youtube.com/playlist?list=PLYyDSR_h1X0yyqqgRpVUd6erdvJKoXqIA

＜リンク先：シミュレータ開発におけるプレスリリース記事＞

侵襲的内視鏡手技シミュレータの社会実装デンカと東北大学の産学連携「Medical Rising STAR®」プロジェクト

https://www.tohoku.ac.jp/japanese/2023/04/press20230425-01-denka.html

出血合併症の再現を含む胆膵内視鏡シミュレータモデルを開発産学連携「Medical Rising STAR」プロジェクト第2弾

https://www.tohoku.ac.jp/japanese/2024/02/press20240219-02-mrs.html

＜リンク先：TEDxTaipei 2014講演被災とレジリエンスについて＞
http://tedxtaipei.com/talks/2014-takeshi-kanno/
※メディア関連出演の記録は社会貢献活動欄の末尾に、東北大学医学部広報一條様のご助力で一覧を作成し掲載しています。
＜リンク先：コンダクター型災害保健医療人材の養成プログラム＞
https://www.dcnd.hosp.tohoku.ac.jp/

Research History 11

2023/04 - Present

Jichi Medical University
2023/04 - Present

Tohoku University
2019/10 - 2023/03

東北大学病院　総合地域医療教育支援部（消化器内科兼務）　助教
2020/08 - 2021/03

Tohoku Medical Megabank Organization Department of Community Medical Supports
2017/10 - 2019/09

Division of Gastroenterology, McMaster University　Research Fellow (Invited Assistant Professor)
2017/10 - 2019/09

Tohoku University　Graduate School of Medicine
2015/04 - 2017/09

東北大学病院卒後研修センター（消化器内科兼務）助教
2012/04 - 2014/03

丸森町国民健康保険丸森病院内科医長
2009/04 - 2011/03

公立志津川病院内科医長
2007/04 - 2009/03

栗原市立栗原中央病院内科医員
2005/04 - 2007/03

National Hospital Organization

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Education 2

Tohoku University　Graduate School of Medicine

2011/04 - 2015/03
Jichi Medical University　School of Medicine

1999/04 - 2005/03

Committee Memberships 9

月刊地域医学　編集委員

2023/10 - Present
日本消化器病学会　支部評議員

2023/03 - Present
文部科学省「ポストコロナ時代の医療人材養成拠点形成事業」多様な山・里・海を巡り個別最適に学ぶ「多地域共創型」医学教育拠点の構築事業　外部評価委員

2023/01 - Present
日本消化器内視鏡学会　支部評議員

2022/07 - Present
日本消化器病学会　消化性潰瘍診療ガイドライン作成委員

2018/08 - Present
高知県災害医療アドバイザー（高知県災害医療対策本部会議参与員）

2013/07 - Present
Cochrane Gut　Editor

2019/07 - 2024/10
宮城県保健福祉部参与（兼務）

2020/04 - 2023/03
宮城県保健福祉部参与（兼務）

2015/09 - 2017/09

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Professional Memberships 8

JAPANESE SOCIETY OF GASTROENTEROLOGY
THE JAPANESE SOCIETY OF INTERNAL MEDICINE
日本消化器がん検診学会
日本災害医学会
日本ヘリコバクター学会
日本医学教育学会
JAPAN PRIMARY CARE ASSOCIATION
JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY

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Research Interests 5

Systematic review
シミュレーション教育
Disaster Medicine
Medical Education
Gastroenterology

Research Areas 3

Life sciences / Hygiene and public health (non-laboratory) / Systematic review
Life sciences / Healthcare management, medical sociology /
Life sciences / Gastroenterology /

Awards 6

2024年度日本ヘリコバクター学会学術集会賞（優秀賞）

2024/10
平成29年度日本消化器内視鏡学会学会賞

2017/10
Symbols of Tomorow

2013/10
次代を創る100人『The Nikkei Business 100』

2011/10　日経ビジネス　「この世の終わり」と光
希望の象徴

2011/05　米国研究製薬工業協会: PhRMA
The 100 Most Influential People of 2011

2011/04

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Papers 100

Effectiveness of Japanese traditional medicine (Kamikihito and Saikokeishito) for treating long COVID: a prospective observational study Peer-reviewed

Rie Ono, Shin Takayama, Ryutaro Arita, Kota Ishizawa, Akiko Kikuchi, Michiaki Abe, Minoru Ohsawa, Natsumi Saito, Takeshi Kanno, Koh Onodera, Tadashi Ishii

Frontiers in Medicine　12　2025/07/21
Publisher: Frontiers Media SA
DOI： 10.3389/fmed.2025.1609812 　

eISSN： 2296-858X

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Background Long COVID symptoms, especially brain fog, significantly impair patient quality of life (QOL); however, effective treatments remain elusive. Japanese traditional medicine (JTM, usually called Kampo medicine) is often used adjunctively to treat patients with diverse manifestations of long COVID. Objective To evaluate the effectiveness of JTM in treating long COVID using a comprehensive QOL assessment. Methods This single-center, prospective observational study evaluated QOL changes in patients with symptoms persisting beyond 28 days from the onset of COVID-19 (long COVID) who visited our general medicine outpatient department between October 2021 and August 2024. The treatment plan was determined by the attending physician based on the patient’s condition. The health-related QOL (HR-QOL) was comprehensively assessed using EuroQol-5 demensions-5levels (EQ-5D-5L) scores (ranging from −0.025 to 1.000, with higher values indicating better HR-QOL) at baseline and 3 months after the first visit. The formulations and factors associated with QOL changes were analyzed using multivariate logistic regression analyses. Results We analyzed 112 patients. The most common symptoms were fatigue (83.9%). The median (interquartile range) HR-QOL of the entire cohort significantly increased from 0.711 (0.561–0.711) at baseline to 0.833 (0.671–0.890) at 3 months (p &lt; 0.0001); the proportion of patients exceeding the national standard significantly increased from 7.1% to 20.4% (p = 0.0037). The brain fog patients group (50.0%, N = 56), the median (interquartile range) HR-QOL of the entire cohort significantly increased from 0.677 (0.551–0.770) at baseline to 0.750 (0.623–0.846) at 3 months (p &lt; 0.005). However, the proportion of patients achieving the Japanese average HR-QOL did not show improvement significantly. A total of 101 patients (90.2%) were treated with JTM, and a combination of kamikihito and saikokeishito was administered to 20 patients. Multivariate regression analysis revealed that the combination usage was associated with greater improvements in the HR-QOL in all patients (odds ratio 5.4) and brain fog patients’ group (odds ratio 6.1). Conclusion Long COVID treatment involving JTM improved the patients’ QOL at 3 months. The combination of kamikihito with saikokeishito may be a potential treatment option for long COVID. However, a randomized controlled trial is required to confirm its efficacy.
Computer‐aided diagnosis for colorectal polyp in comparison with endoscopists: Systematic review and meta‐analysis

Satoshi Shinozaki, Jun Watanabe, Takeshi Kanno, Yuhong Yuan, Tomonori Yano, Hironori Yamamoto

Digestive Endoscopy　2025/05/16
Publisher: Wiley
DOI： 10.1111/den.15047 　

ISSN： 0915-5635

eISSN： 1443-1661

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Objectives Computer‐aided diagnosis (CADx) is anticipated to enhance the prediction of colorectal polyp histology. This study aims to compare the diagnostic accuracy of CADx in the optical diagnosis of colorectal polyps, evaluating its performance against that of both experienced and inexperienced endoscopists. Methods The protocol of this study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD42024585097). Three electronic databases including MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched in September 2024. A bivariate random effects model was employed. The primary outcome was the comparison of sensitivity and specificity between CADx and experienced endoscopists; the secondary outcome was the comparison between CADx and inexperienced endoscopists. Results Twenty‐one studies involving 5477 polyps were included. The pooled sensitivities of CADx and experienced endoscopists were 0.87 (95% confidence interval [CI] 0.82–0.91) and 0.88 (95% CI 0.83–0.91), respectively (P = 0.93). The pooled specificities of CADx and experienced endoscopists were 0.85 (95% CI 0.78–0.90) and 0.87 (95% CI 0.82–0.92), respectively (P = 0.53). In nine studies comparing CADx with inexperienced endoscopists, the pooled sensitivities were 0.88 (95% CI 0.82–0.92) for CADx and 0.85 (95% CI 0.78–0.90) for inexperienced endoscopists (P = 0.46). The pooled specificities were 0.84 (95% CI 0.78–0.88) for CADx and 0.77 (95% CI 0.70–0.83) for inexperienced endoscopists (P = 0.16). Conclusion Computer‐aided diagnosis does not demonstrate superior diagnostic accuracy in optical diagnosis of colorectal polyps compared to endoscopists, regardless of their experience level.
Associations between excessive supragastric belching and esophageal reflux factors in patients with PPI-refractory GERD in Japan Peer-reviewed

Yukihiro Shuto, Masahiro Saito, Tomoyuki Koike, Kaoru Koizumi, Yumiko Kaise, Kazuma Yachi, Yutaka Hatayama, Yohei Ogata, Xiaoyi Jin, Takeshi Kanno, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

Journal of Gastroenterology　2025/05/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00535-025-02258-4 　

ISSN： 0944-1174

eISSN： 1435-5922

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Abstract Background No studies have evaluated the prevalence of supragastric belching (SGB) in Japanese patients with proton pump inhibitor (PPI)-refractory non-erosive reflux disease (NERD) under off-PPI conditions. This study aimed to clarify the association between excessive SGB and esophageal reflux factors. Methods Seventy-nine patients with PPI-refractory NERD under off-PPI treatment were evaluated using 24-h multichannel intraluminal impedance pH monitoring and high-resolution impedance manometry. Results The prevalence values of excessive SGB overall and in the true NERD, reflux hypersensitivity, and function heartburn subtypes were 19.0%, 35.7%, 5.3%, and 12.5%, respectively. The monitoring results demonstrated that, compared with those without excessive SGB, patients with excessive SGB had a significantly higher total number of reflux events (63 episodes vs. 39 episodes, p = 0.01) and significantly greater acid exposure time (6.1% vs. 1.35%, p = 0.01). However, bolus exposure did not differ significantly between the groups (p = 0.09). The manometry findings showed no significant differences in lower esophageal sphincter pressure, integrated relaxation pressure, and distal contractile integral between the groups. Regarding gastroesophageal reflux, 22% of the SGB episodes were preceded by reflux, 55% occurred independently, and 23% were followed by reflux. Conclusions The prevalence of excessive SGB in Japanese patients with PPI-refractory NERD under off-PPI conditions was 19.0% and most commonly observed in patients with true NERD (35.7%). Patients with excessive SGB exhibited increased esophageal acid exposure, and reflux events were sometimes observed before SGB episodes.
Co-stimulation with high-fat diet and acidic bile salts may promote Warburg effect in gastric carcinogenesis around the squamo-columnar junction in Gan mice

Koichiro Sudo, Kaname Uno, Toru Tamahara, Naoki Asano, Keisuke Kusano, Mizuki Tanabe, Kouya Ogasawara, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

American Journal of Physiology-Gastrointestinal and Liver Physiology　2025/04/17
Publisher: American Physiological Society
DOI： 10.1152/ajpgi.00305.2024 　

ISSN： 0193-1857

eISSN： 1522-1547

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Epidemiological studies demonstrated relationships between gastric cardia adenocarcinoma (GCA) and metabolic syndrome (MetS). We aimed to clarify mechanism underlying their relationship. To investigate whether systemic inflammation against high-fat diet (HFD)-related dysbiosis promotes Warburg effect in tumors at the squamo-columnar junction (SCJ), we applied K19-Wnt1/C2mE (Gan) mice, fed either HFD or control diet ± acidic bile salts (ABS) with/without clodronate liposomes (CLs), and in vitro studies using MKN7 cells with/without THP1-derived macrophages. Then, we assessed involvement of oxidative stress (OS) in Warburg effect by comparing between nuclear factor-erythroid 2-related factor 2 (Nrf2) knockout-Gan mice and Gan mice. Tumors with macrophage infiltration in HFD+ABS group were larger than in Control group. Gene Set Enrichment Analysis revealed enhancement of the OS signaling in tumor of HFD+ABS group. HFD+ABS group mice demonstrated induction of OS, Nqo1, TNFα, and Warburg effect in tumors and mucosal barrier dysfunction of dysbiotic gut. All of them were abolished with diminishing macrophage infiltration by additional CLs treatment. Stimulation with TNFα, but not ABS nor lipopolysaccharide, on MKN7 cells activated Warburg effect. In MKN7 cells co-cultured with the macrophages whose TNFa expression was induced by the lipopolysaccharide pretreatment, Warburg effect was enhanced in the TNFα concentration-dependent manners. In Nrf2 knockout-Gan mice, tumors shrank with reducing OS, TNFα, and Warburg effect, along with decreasing macrophage infiltration. Accordingly, MetS may develop GCA through the Nrf2-related Warburg effect under the TNFα stimulation from the macrophages activated by both local ABS exposure and systemic lipopolysaccharide exposure from leaky gut with HFD-related dysbiosis.
Prevalence and risk factors for lymph node metastasis in duodenal neuroendocrine tumors: a systematic review and meta-analysis

Yohei Ogata, Waku Hatta, Takeshi Kanno, Yutaka Hatayama, Masahiro Saito, Xiaoyi Jin, Tomoyuki Koike, Akira Imatani, Yuhong Yuan, Atsushi Masamune

Journal of Gastroenterology　2025/04/03
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00535-025-02247-7 　

ISSN： 0944-1174

eISSN： 1435-5922

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Abstract Background Although the status of lymph node metastasis (LNM) is crucial in determining treatment strategy for duodenal neuroendocrine tumors (D-NETs), robust evidence for their potential LNM risk remains lacking. This systematic review aimed to summarize the prevalence and risk factors of LNM in D-NETs. Methods This systematic review of electronic databases identified eligible case–control and cohort studies for D-NET resected either endoscopically or surgically, published from 1990 to 2023. The primary outcome was the pooled prevalence of LNM in D-NETs. Secondary outcomes included the pooled prevalence of LNM according to tumor location and functionality, as well as identifying pathological risk factors for LNM. Meta-analysis was performed. Results We identified 36 studies that involved 1,396 patients with D-NETs, including 326 with LNM. The pooled prevalence of LNM in D-NETs was 22.7% (95% confidence interval [CI] 17.3–29.2%). The prevalence was high in ampullary/peri-ampullary D-NETs and functional D-NETs (46.8 and 53.3%, respectively), whereas it was low in non-functional, non-ampullary D-NETs (NAD-NETs) (9.5%). Pathological risk factors for LNM in NAD-NETs included tumor size > 10 mm (odds ratio [OR] 7.31 [95% CI 3.28–16.31]), tumor invasion into the muscularis propria or deeper (OR 7.79 [3.65–16.61]), lymphovascular invasion (OR 5.67 [2.29–14.06]), and World Health Organization grading of G2 (OR 2.47 [1.03–5.92]). Conclusion Approximately one-fourth of the patients with D-NETs had LNM. Endoscopic resection might be acceptable for non-functional NAD-NETs with diameters of 10 mm or less, but additional surgical resection with lymphadenectomy may be recommended for cases exhibiting pathological risk factors.
Type 2 and type 3 gastric neuroendocrine tumors have high risk of lymph node metastasis: Systematic review and meta-analysis International-coauthorship

Yohei Ogata, Waku Hatta, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Naoki Asano, Tomoyuki Koike, Akira Imatani, Yuhong Yuan, Atsushi Masamune

Digestive Endoscopy　2025/04
Publisher: Wiley
DOI： 10.1111/den.15026 　

ISSN： 0915-5635

eISSN： 1443-1661

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Objectives Lymph node metastasis (LNM) is crucial in determining treatment strategies for gastric neuroendocrine tumors (gNETs). While type 3 is considered more aggressive than types 1 and 2 within the clinical subtype of gNETs, the supporting data were insufficient, due to their rarity. We aimed to study the prevalence and risk factors associated with LNM in gNETs. Methods We searched electronic databases from 1990 to 2023 to identify case–control and cohort studies regarding gNETs resected either endoscopically or surgically. The primary outcome measured was the pooled prevalence of LNM in gNETs. Secondary outcomes included categorizing the prevalence of LNM by clinical subtypes and identifying pathological risk factors associated with LNM in gNETs. Results We included 28 studies, involving 1742 patients, among whom 240 had LNM (pooled prevalence rate, 11.8%; 95% confidence interval 7.6–17.9%). The pooled prevalence rates of LNM for type 1, type 2, and type 3 gNETs were 6.0%, 38.5%, and 23.2%, respectively. Type 2 (odds ratio [95% confidence interval] 11.53 [3.46–38.49]) and type 3 (6.88 [3.79–12.49]) gNETs exhibited a higher risk for LNM compared to type 1. Pathological risk factors for LNM included tumor size >10 mm (4.18 [1.91–9.17]), tumor invasion into the muscularis propria or deeper (11.21 [3.50–35.92]), grade 2/grade 3 (5.96 [2.65–13.40]), and lymphovascular invasion (34.50 [6.70–177.51]). Conclusion We demonstrated that type 2 gNETs, as well as type 3, had a high risk of LNM. Additionally, four pathological risk factors associated with LNM were identified.
【Award Report】H. pylori感染状態とディスベプシアの頻度：成人胃がん検診事業データに基づく疫学的分析

菅野武, 鈴木直生, 小池智幸, 千葉隆士, 浅沼清孝, 加藤勝章, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本ヘリコバクター学会誌　26　(2)　94-96　2025/02
Four cases in which PuraStat® was used for ulcers related to physical stress at our hospital

Ulcer research　51　35-39　2024/09/27
The Impact of Psychological Stress on Gastric and Duodenal Ulcer Formation: Insights from Acute Disastrous Situations and Idiopathic Peptic Ulcers

Ulcer Research　51　24-30　2024/09/27
ひろげる!深める!消化器ナース+トピック大規模災害と消化器疾患～緊急時に私たちができること～

菅野武, 石井正

消化器ナーシング　29　(8)　754-759　2024/08
Sequential Sampling of the Gastrointestinal Tract to Characterize the Entire Digestive Microbiome in Japanese Subjects Peer-reviewed

Kota Ishizawa, Toru Tamahara, Suguo Suzuki, Yutaka Hatayama, Bin Li, Michiaki Abe, Yuichi Aoki, Ryutaro Arita, Natsumi Saito, Minoru Ohsawa, Soichiro Kaneko, Rie Ono, Shin Takayama, Muneaki Shimada, Kazuki Kumada, Tomoyuki Koike, Atsushi Masamune, Ko Onodera, Tadashi Ishii, Ritsuko Shimizu, Takeshi Kanno

Microorganisms　12　(7)　1324-1324　2024/06/28
Publisher: MDPI AG
DOI： 10.3390/microorganisms12071324 　

eISSN： 2076-2607

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The gastrointestinal (GI) tract harbors trillions of microorganisms known to influence human health and disease, and next-generation sequencing (NGS) now enables the in-depth analysis of their diversity and functions. Although a significant amount of research has been conducted on the GI microbiome, comprehensive metagenomic datasets covering the entire tract are scarce due to cost and technical challenges. Despite the widespread use of fecal samples, integrated datasets encompassing the entire digestive process, beginning at the mouth and ending with feces, are lacking. With this study, we aimed to fill this gap by analyzing the complete metagenome of the GI tract, providing insights into the dynamics of the microbiota and potential therapeutic avenues. In this study, we delved into the complex world of the GI microbiota, which we examined in five healthy Japanese subjects. While samples from the whole GI flora and fecal samples provided sufficient bacteria, samples obtained from the stomach and duodenum posed a challenge. Using a principal coordinate analysis (PCoA), clear clustering patterns were identified; these revealed significant diversity in the duodenum. Although this study was limited by its small sample size, the flora in the overall GI tract showed unwavering consistency, while the duodenum exhibited unprecedented phylogenetic diversity. A visual heat map illustrates the discrepancy in abundance, with Fusobacteria and Bacilli dominating the upper GI tract and Clostridia and Bacteroidia dominating the fecal samples. Negativicutes and Actinobacteria were found throughout the digestive tract. This study demonstrates that it is possible to continuously collect microbiome samples throughout the human digestive tract. These findings not only shed light on the complexity of GI microbiota but also provide a basis for future research.
Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding: a Cochrane review (in Spanish) International-journal International-coauthorship

Takeshi Kanno, Takeshi Kanno, Yuhong Yuan, Frances Tse, Colin W Howden, Paul Moayyedi, Grigorios I Leontiadis

Emergencias　2024/06/26
Publisher: SEMES (Sociedad Espanola de Medicina de Urgencias y Emergencias)
DOI： 10.55633/s3me/055.2024 　

ISSN： 1137-6821

eISSN： 2386-5857

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This is an original article published by Cochrane Reviews and translated into Spanish under agreement between Cochrane Foundation and EMERGENCIAS. The original article as published in English is available at: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD0054 15.pub4/full
A Case Series of Post-COVID Conditions with Fatigability Treated with Saikokeishito

Rie Ono, Shin Takayama, Natsumi Saito, Ryutaro Arita, Akiko Kikuchi, Kota Ishizawa, Takeshi Kanno, Akito Sugawara, Minoru Ohsawa, Michiaki Abe, Ko Onodeara, Tetsuya Akaishi, Tadashi Ishii

An Official Journal of the Japan Primary Care Association　47　(2)　49-55　2024/06/20
Publisher: The Japan Primary Care Association
DOI： 10.14442/generalist.47.49 　

ISSN： 2185-2928

eISSN： 2187-2791
Oral alkalinizing supplementation suppressed intrarenal reactive oxidative stress in mild-stage chronic kidney disease: a randomized cohort study.

Michiaki Abe, Takuhiro Yamaguchi, Seizo Koshiba, Shin Takayama, Toshiki Nakai, Koichiro Nishioka, Satomi Yamasaki, Kazuhiko Kawaguchi, Masanori Umeyama, Atsuko Masaura, Kota Ishizawa, Ryutaro Arita, Takeshi Kanno, Tetsuya Akaishi, Mariko Miyazaki, Takaaki Abe, Tetsuhiro Tanaka, Tadashi Ishii

Clinical and experimental nephrology　2024/06/13

DOI： 10.1007/s10157-024-02517-3 　

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BACKGROUND: The beneficial effects of oral supplements with alkalinizing agents in patients with chronic kidney disease (CKD) have been limited to the severe stages. We investigated whether two types of supplements, sodium bicarbonate (SB) and potassium citrate/sodium citrate (PCSC), could maintain renal function in patients with mild-stage CKD. METHODS: This was a single-center, open-labeled, randomized cohort trial. Study participants with CKD stages G2, G3a, and G3b were enrolled between March 2013 and January 2019 and randomly assigned by stratification according to age, sex, estimated glomerular filtration rate (eGFR), and diabetes. They were followed up for 6 months (short-term study) for the primary endpoints and extended to 2 years (long-term study) for the secondary endpoints. Supplementary doses were adjusted to achieve an early morning urinary pH of 6.8-7.2. We observed renal dysfunction or new-onset cerebrovascular disease and evaluated urinary surrogate markers for renal injury. RESULTS: Overall, 101 participants were registered and allocated to three groups: standard (n = 32), SB (n = 34), and PCSC (n = 35). Two patients in the standard group attained the primary endpoints (renal stones and overt proteinuria) but were not statistically significant. There was one patient in the standard reduced eGFR during the long-term study (p = 0.042 by ANOVA). SB increased proteinuria (p = 0.0139, baseline vs. 6 months), whereas PCSC significantly reduced proteinuria (p = 0.0061, baseline vs. 1 year, or p = 0.0186, vs. 2 years) and urinary excretion of 8-hydroxy-2'-deoxyguanosine (p = 0.0481, baseline vs. 6 months). CONCLUSION: This study is the first to report supplementation of PCSC reduced intrarenal oxidative stress in patients with mild-stage CKD.
Simulation-based training of endoscopic hemostasis for Japanese pediatric endoscopy learners: a pilot program Peer-reviewed

Takeshi Kanno, Itaru Iwama, Yutaka Hatayama, Suguo Suzuki, Yutaro Arata, Tomoyuki Koike, Atsushi Masamune

iGIE　3　(2)　230-236　2024/06
Publisher: Elsevier BV
DOI： 10.1016/j.igie.2024.04.003 　

ISSN： 2949-7086
Appendicitis after endoscopic band ligation for massive ileocecal hemorrhage Peer-reviewed

Hiroto Sato, Yu Yamamoto, Akira Kaizuka, Yu Ohtaki, Makoto Toda, Shoichiro Fujishima, Nakao Shirahata, Ryusuke Ae, Takeshi Kanno

DEN Open　5　(1)　2024/05/28
Publisher: Wiley
DOI： 10.1002/deo2.392 　

ISSN： 2692-4609

eISSN： 2692-4609

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Abstract A 68‐year‐old man was admitted with hematochezia. Emergency computed tomography showed multiple diverticula throughout the colon. Initial colonoscopy on day 2 showed no active bleeding, but massive hematochezia on day 3 led to the performance of an emergency endoscopy. Substantial bleeding in the ileocecal area obscured the visual field, making it challenging to view the area around the bleeding site. Two endoscopic band ligations (EBLs) were applied at the suspected bleeding sites. Hemostasis was achieved without active bleeding after EBL. However, the patient developed lower right abdominal pain and fever (39.4°C) on day 6. Urgent computed tomography revealed appendiceal inflammation, necessitating emergency open ileocecal resection for acute appendicitis. Pathological examination confirmed acute phlegmonous appendicitis, with EBLs noted at the appendiceal orifice and on the anal side. This case illustrates the efficacy of EBL in managing colonic diverticular bleeding. However, it also highlights the risk of appendicitis due to EBL in cases of ileocecal hemorrhage exacerbated by poor visibility due to substantial bleeding. Endoscopists need to consider this rare but important complication when performing EBL in similar situations.
Similar Effect of Vonoprazan and Oral Proton Pump Inhibitors for Preventing Rebleeding in Cases of Upper Gastrointestinal Bleeding

Hiroko Abe, Kunio Tarasawa, Waku Hatta, Tomoyuki Koike, Isao Sato, Yoshitaka Ono, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

Internal Medicine　63　(7)　911-918　2024/04/01
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.2211-23 　

ISSN： 0918-2918

eISSN： 1349-7235
Linked Color Imaging of Barrett’s Esophageal Adenocarcinoma: Effects on Visibility

Masahiro Saito, Tomoyuki Koike, Yuki Ohara, Yohei Ogata, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

Gastroenterology Insights　2024/02/05

DOI： 10.3390/gastroent15010010 　
Interactive training with a novel simulation model for upper gastrointestinal endoscopic hemostasis improves trainee technique and confidence International-journal International-coauthorship Peer-reviewed

Takeshi Kanno, Yutaro Arata, Eric Greenwald, Paul Moayyedi, Suguo Suzuki, Yutaka Hatayama, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Yutaka Kagaya, Tomoyuki Koike, Atsushi Masamune

Endoscopy International Open　12　(02)　E245-E252　2024/01/17
Publisher: Georg Thieme Verlag KG
DOI： 10.1055/a-2248-5110 　

ISSN： 2364-3722

eISSN： 2196-9736

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Abstract Background and study aims Endoscopic hemostasis is a life-saving procedure for gastrointestinal bleeding; however, training for it is often performed on real patients and during urgent situations that put patients at risk. Reports of simulation-based training models for endoscopic hemostasis are scarce. Herein, we developed a novel simulator called “Medical Rising STAR-Ulcer type” to practice endoscopic hemostasis with hemoclips and coagulation graspers. This study aimed to evaluate the reproducibility of the clinical difficulty of this model and the effectiveness of simulation-based training for clipping hemostasis. Patients and methods This was a prospective educational study. Fifty gastroenterology residents from Japan and Canada were recruited to participate in a simulation-based training program. The primary outcome was the success rate for clipping hemostasis. We measured differences in trainee subjective assessment scores and evaluated the co-occurrence network based on comments after training. Results The hemostasis success rate of the trainees significantly increased after instruction (64% vs. 86%, P < 0.05). The success rate for ulcers in the upper body of the stomach (59%), a high-difficulty site, was significantly lower than that for ulcers in the antrum, even after feedback and instruction. Trainee self-perceived proficiency and confidence significantly improved after simulation-based training (P < 0.05). Co-occurrence network analysis showed that trainees valued a structured learning approach, acknowledged simulator limitations, and recognized the need for continuous skill refinement. Conclusions Our study demonstrates the potential of our simulation-based training model as a valuable tool for improving technical skills and confidence in trainees learning to perform endoscopic hemostasis.
A novel dry simulator model for learning comprehensive endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomy procedures while minimizing adverse bleeding events (with Video). International-journal Peer-reviewed

Yutaka Hatayama, Takeshi Kanno, Tetsuya Takikawa, Ryotaro Matsumoto, Yutaro Arata, Suguo Suzuki, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Shin Miura, Waku Hatta, Shin Hamada, Kaname Uno, Kiyoshi Kume, Kazuhiro Kikuta, Naoki Asano, Akira Imatani, Tomoyuki Koike, Atsushi Masamune

Digestion　105　(2)　149-156　2024/01/10

DOI： 10.1159/000536217 　

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BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincterotomy (EST) are essential skills for endoscopic cholangio-pancreatic procedures. However, these procedures have a high incidence of adverse events, and most training is currently patient-based. Herein, we aimed to develop an ERCP/EST simulator model to address the need for safer training alternatives, especially for learners with limited ERCP experience. METHODS: The model was designed to facilitate the use of actual endoscopic devices, supporting learning objectives that align with the components of the validated Bethesda ERCP Skill Assessment Tool (BESAT). BESAT focuses on skills such as papillary alignment and maintenance of duodenoscope position, gentle and efficient cannulation, controlled sphincterotomy in the correct trajectory, and guidewire manipulation. Thirty gastroenterology trainees used the simulator between May 2022 and March 2023, and their satisfaction was assessed using a visual analog scale (VAS) and pre- and post-training questionnaires. RESULTS: The novel simulator model comprises a disposable duodenal papillary portion, suitable for incision with an electrosurgical knife, alongside washable upper gastrointestinal tract and bile duct portions, designed for repeated use. The duodenal papillary portion enabled reproduction of a realistic endoscope position and the adverse bleeding events due to improper incisions. The bile duct portion allowed for the reproduction of fluoroscopic-like images, enabling learners to practice guidewire guidance and insert other devices. After training, the median VAS score reflecting the expectation for model learning significantly increased from 69.5 (interquartile range [IQR]:55.5-76.5) to 85.5 (IQR: 78.0-92.0) (P<0.01). All participants expressed their desire for repeated simulator training sessions. CONCLUSIONS: This innovative simulator serves as a practical educational tool, particularly beneficial for novices in ERCP. It facilitates hands-on practice with actual devices, enhancing procedural fluency and understanding of precise incisions to minimize the risk of bleeding complications during EST.
総論 (2) 消化管出血の診断手順

小池智幸, 八田和久, 尾形洋平, 齊藤真弘, 菅野武, 正宗淳

臨牀消化器内科　38　(11)　1360-1367　2023/10

DOI： 10.19020/CG.0000002804 　
Discrepancy between Abdominal Symptoms and Endoscopic Findings in Patients with Gastro-duodenal Eosinophilia: A Case Series

Hideyuki Sugawara, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Tomoyuki Koike, Atsushi Masamune

Internal Medicine　62　(18)　2661-2665　2023/09/15
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.1137-22 　

ISSN： 0918-2918

eISSN： 1349-7235
13．非Helicobacter pylori・非NSAIDs潰瘍の診療

菅野武, 川邉誠, 小野義高, 宇野要, 小池智幸, 正宗淳

Progress in Medicine　43　(9)　825-829　2023/09
A Case of Gastric Cancer With a Rare Spreading Pattern Into the Submucosal Layer International-journal

Yutaka Hatayama, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Tomoyuki Koike, Atsushi Masamune

Journal of the Canadian Association of Gastroenterology　6　(4)　135-136　2023/08
Publisher: Oxford University Press (OUP)
DOI： 10.1093/jcag/gwac012 　

ISSN： 2515-2084

eISSN： 2515-2092
A case of refractory bleeding from duodenal angioectasia with acquired hemophilia A.

Hiroko Abe, Masahiro Saito, Kaname Uno, Tomoyuki Koike, Satoshi Ichikawa, Masashi Saito, Takeshi Kanno, Waku Hatta, Naoki Asano, Atsushi Masamune

Clinical journal of gastroenterology　16　(3)　355-360　2023/06

DOI： 10.1007/s12328-023-01790-1 　

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Acquired hemophilia A (AHA) is a coagulation disorder related to the factor VIII inhibitors, which might cause intractable bleeding of gastrointestinal tracts. However, its scarcity makes it difficult to recognize AHA as a pitfall of endoscopic hemostasis failure. An 81-year-old female with a history of endoscopic treatment for colon polyps visited a local hospital with chief compliments of bloody stool and severe anemia. During several examinations for the bleeding origin, esophagogastroduodenoscopy depicted a 5 mm-sized hemorrhagic angioectasia of the duodenum, followed by treatment with argon plasma coagulation. However, hemostasis was not achieved by multiple sessions of endoscopic hemostasis and transcatheter arterial embolization, so blood transfusion was repeatedly done and she was transferred to our hospital. Laboratory data showed severe anemia with coagulation disorder. Based on the results of von Willebrand factor activity, factor VIII activity and factor VIII inhibitor, we diagnosed AHA as a comorbidity. Endoscopic hemostasis was confirmed only after improvement of APTT level and negative for the factor VIII inhibitor by hemostatic bypass treatment with recombinant active factor VII and immunosuppressive therapy with prednisolone and cyclophosphamide. In case of refractory bleeding of gastrointestinal tract, we should suspect of a comorbidity of coagulation disorder like AHA.
Linked color imaging versus conventional white light colonoscopy for the detection of colorectal polyps

Jun Watanabe, Takeshi Kanno, Eiichi Kakehi, Kazuma Rifu, Takehiro Kagaya, Kazuhiko Kotani, Yuki Kataoka

Cochrane Database of Systematic Reviews　2023　(5)　2023/05/30
Publisher: Wiley
DOI： 10.1002/14651858.cd015476 　

eISSN： 1465-1858
Progress and treatment of “long <scp>COVID</scp>” in non‐hospitalized patients: A single‐center retrospective cohort study

Rie Ono, Ryutaro Arita, Shin Takayama, Takeshi Kanno, Akiko Kikuchi, Satoko Suzuki, Minoru Ohsawa, Natsumi Saito, Michiaki Abe, Koh Onodera, Tetsuya Akaishi, Yasunori Tadano, Tadashi Ishii

Traditional & Kampo Medicine　10　(2)　150-158　2023/05/25
Publisher: Wiley
DOI： 10.1002/tkm2.1370 　

ISSN： 2053-4515

eISSN： 2053-4515

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Abstract Background “Long COVID” or “post‐COVID conditions” describes prolonged symptoms after the acute phase of coronavirus disease 2019 (COVID‐19). However, there is a paucity of published reports on its treatment. Method This retrospective cohort study included adult, non‐hospitalized patients with COVID‐19 symptoms at least one month after the onset who had been examined at the isolation facility in Miyagi prefecture between October 2020 and September 2021. Results In total, 70 patients with a median age of 46 (21–69) years were included, and 37 were women (52.9%). The median time from onset to the end of treatment was 46 (28–396) days. Thirty‐eight patients (53.5%) showed improvement in all symptoms, while four (5.7%) did not recover within the study period. The symptoms at six months with high residual rates were dizziness (33.3%), fatigue (14.3%), myalgia (14.3%), abdominal discomfort (14.3%), and taste dysfunction (11.8%). For treatment of prolonged symptoms, formulae of Kampo medicine (Japanese traditional medicine) were used alone or in combination with Western medications in 76%, 66%, 53%, and 66% of patients at 1–2 months, 2–3 months, 3–6 months, and over 6 months respectively. Kampo formulae with anti‐inflammatory effects were used in the early period; however, tonifying formulae and blood stasis‐resolving formulae were used in the late period. Conclusion Non‐hospitalized patients with COVID‐19 may suffer from persistent symptoms after the acute phase of infection. For the management of long COVID, a comprehensive and holistic approach is needed. Kampo medicine should be considered as a treatment option for long COVID.
【この領域のランドマーク論文はこう読むべき!】Systematic reviewから読み解く早期胃癌に対する内視鏡治療非治療切除(eCuraC-2)例に対する追加治療

八田和久, 後藤田卓志, 菅野武, 小池智幸, 正宗淳

消化器クリニカルアップデート　4　(2)　197-202　2023/02
Publisher: 医学図書出版(株)
ISSN： 2435-256X
Novel simulator of endoscopic hemostasis with actual endoscope and devices International-journal

Takeshi Kanno, Yutaro Arata, Yutaka Hatayama, Tomoyuki Koike, Atsushi Masamune

VideoGIE　8　(2)　56-59　2023/02
Publisher: Elsevier BV
DOI： 10.1016/j.vgie.2022.10.004 　

ISSN： 2468-4481
非HP非NSAID・難治性胃・十二指腸潰瘍の診断と治療非H.pylori非NSAIDs潰瘍の診療鑑別診断と特発性潰瘍

菅野武, 小池智幸, 正宗淳

日本消化管学会雑誌　7　(Suppl.)　161-161　2023/01
Publisher: (一社)日本消化管学会
ISSN： 2433-3840

eISSN： 2435-8967
Predictors for the Development of Hypoxia or Prolonged Acute Symptoms among Non-Hospitalized Mild-to-Moderate Patients with Coronavirus Disease 2019

Yasunori Tadano, Tetsuya Akaishi, Satoko Suzuki, Rie Ono, Natsumi Saito, Ryutaro Arita, Takeshi Kanno, Junichi Tanaka, Akiko Kikuchi, Minoru Ohsawa, Shin Takayama, Michiaki Abe, Ko Onodera, Tadashi Ishii

The Tohoku Journal of Experimental Medicine　260　(3)　231-244　2023
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2023.j038 　

ISSN： 0040-8727

eISSN： 1349-3329
PREDICTORS OF EARLY AND LATE MORTALITY AFTER THE TREATMENT FOR EARLY GASTRIC CANCERS

OGATA Yohei, HATTA Waku, OHARA Yuki, KOIKE Tomoyuki, ABE Hiroko, SAITO Masahiro, JIN Xiaoyi, KANNO Takeshi, UNO Kaname, ASANO Naoki, IMATANI Akira, YAMAMURA Akihiro, TANAKA Naoki, KAMEI Takashi, UNNO Michiaki, NAKAMURA Tomohiro, NAKAYA Naoki, MASAMUNE Atsushi

GASTROENTEROLOGICAL ENDOSCOPY　65　(2)　162-172　2023
Publisher: Japan Gastroenterological Endoscopy Society
DOI： 10.11280/gee.65.162 　

ISSN： 0387-1207

eISSN： 1884-5738

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Objectives: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately. Methods: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of 3 years. Results: We enrolled 1439 patients with a median follow-up period of 79 months. The 5-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥85 years (hazard ratio [HR] 2.88 and 4.54, respectively) and Eastern Cooperative Oncology Group Performance Status ≥2 (HR 3.00 and 4.19, respectively). Charlson comorbidity index ≥2 (HR 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥3 (HR 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥0.028 (HR 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR 2.26), intermediate- (HR 2.12)/high-risk (HR 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR 1.70) were predictors for early mortality. Conclusion: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality
特発性胃潰瘍（Ⅲ.陥凹を呈する病変 1.上皮性非腫瘍性陥凹病変）

菅野武, 小池智幸, 正宗淳

胃疾患アトラス（消化器内視鏡 34巻増刊号）　188-189　2022/10/22
Publisher: 東京医学社

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ISBN 978-4-88563-665-3
上部消化管内視鏡治療におけるP-CABの後出血予防効果 propensity scoreを用いたデータベース解析

阿部寛子, 八田和久, たら澤邦男, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

潰瘍　49　55-55　2022/10
Publisher: (一社)日本潰瘍学会
ISSN： 2189-7956
Feasibility of Support by Family Practitioners in Reducing Colorectal Cancer-Related Death among Outpatients Who Have Not Undergone Colorectal Cancer Screening International-journal Peer-reviewed

Ryo Sugaya, Takeshi Kanno, Hirohisa Yasaka, Misuzu Masu, Masataka Otomo, Tomoyuki Koike

Diagnostics　12　(8)　1782-1782　2022/07/22
Publisher: MDPI AG
DOI： 10.3390/diagnostics12081782 　

eISSN： 2075-4418

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We aimed to clarify the effectiveness of interventions in outpatients who did not undergo colorectal cancer (CRC) screening. From September 2012 to August 2013, we conducted a project, which showed that the immunological fecal occult blood test (FOBT) was actively recommended for outpatients who were ≥40 years of age, attended the Marumori Hospital regularly, and were not screened for CRC in the previous two years. We evaluated the detection rate of CRC and the disease specific survival ratio in February 2021 among patients with positive FOBT results during the retrospective cohort study. Overall, 388 (91%) out of the 425 outpatients submitted their stool samples. Among 388 outpatients, 66 tested positive for FOBT. While both the positive rate of FOBT and the detection rate of CRC (17% and 0.77%, respectively) were significantly higher than those in the nationwide administrative examination (5.7% and 0.13%, respectively) (p < 0.05), there was no statistically significant difference in the detection rate, compared with the group aged 65 years and older in the nationwide administrative examination. The 7-year CRC-specific survival ratio was 98.5%. Active promotion of FOBT at primary care institutions for outpatients who did not undergo CRC screening may contribute to reducing the frequency of CRC-related deaths.
Suppressed cellular senescence mediated by T-box3 in aged gastric epithelial cells may contribute to aging-related carcinogenesis International-journal

Akio Takeuchi, Naoki Asano, Akira Imatani, Masashi Saito, Xiaoyi Jin, Masahiro Saito, Takeshi Kanno, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

Cancer Research Communications　2　(8)　772-783　2022/07/14
Publisher: American Association for Cancer Research (AACR)
DOI： 10.1158/2767-9764.crc-22-0084 　

eISSN： 2767-9764

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Abstract Aging is a risk factor for cancers in various organs. Recent advances in the organoid culturing system have made it viable to investigate the influence of aging utilizing these mini organs. In this study, we aimed to examine the implications of aging for gastric carcinogenesis. Gastric organoids established from aged mice grew larger, proliferated vigorously, and survived longer than that from young mice. Since Wnt/b-catenin signaling was intensified in the aged organoids and since removal of Wnt-related factors diminished their proliferation, we investigated for Wnt target gene that contributed to enhanced proliferation and discovered that the aged organoids expressed the transcription factor T-box3 (Tbx3), which has been reported to suppress cellular senescence. Indeed, cellular senescence was suppressed in the aged organoids, and this resulted from enhanced G2/M transition. As for the mechanism involved in the intensified Wnt/b-catenin signaling, we identified that Dickkopf3 (Dkk3) expression was reduced in the aged organoids due to methylation of the Dkk3 gene. Finally, the expression of TBX3 was enhanced in human atrophic gastritis and even more enhanced in human gastric cancers. In addition, its expression correlated positively with patients' age. These results indicated that the emergence of anti-senescent property in aged gastric organoids due to enhanced Tbx3 expression led to accelerated cellular proliferation and organoid formation. Since the enhanced Tbx3 expression seen in aged gastric organoids was also observed in human gastric cancer tissues, this Dkk3-Wnt-Tbx3 pathway may be involved in aging-related gastric carcinogenesis.
What Is the Prevalence of Clinically Significant Endoscopic Findings in Subjects with Dyspepsia? Updated Systematic Review and Meta-analysis International-journal International-coauthorship

Siavosh Nasseri-Moghaddam, Amir-Hossein Mousavian, Amir Kasaeian, Takeshi Kanno, Yuhong Yuan, Alex C. Ford, Paul Moayyedi

Clinical Gastroenterology and Hepatology　2022/06
Publisher: Elsevier BV
DOI： 10.1016/j.cgh.2022.05.041 　

ISSN： 1542-3565
Response to Glucocorticoid Therapy in Patients with Mild to Moderate Coronavirus Disease 2019 at a Japanese Care Facility

Akiko Kikuchi, Ryutaro Arita, Rie Ono, Yasunori Tadano, Natsumi Saito, Tetsuya Akaishi, Takeshi Kanno, Minoru Osawa, Shin Takayama, Michiaki Abe, Ko Onodera, Tadashi Ishii

The Tohoku Journal of Experimental Medicine　257　(2)　97-106　2022/06
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j022 　

ISSN： 0040-8727

eISSN： 1349-3329

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The fifth wave of the coronavirus disease 2019 (COVID-19) pandemic caused by delta variant infection depleted medical resources, and the Japanese government announced glucocorticoid use for outpatients. An appropriate outpatient-glucocorticoid treatment for COVID-19 has not been established; therefore, we created treatment manuals with indications for glucocorticoid administration in a care facility adequately equipped to manage patients with mild to moderate COVID-19. Thirty-eight patients (24 males, 14 females; mean age 40.5 ± 11.8 years) were treated with glucocorticoids from August 1 to October 1, 2021 [COVID-19 staging, mild (n = 1), moderate I (n = 19), and moderate II (n = 18)]. Patients were treated with 6.6 mg/day d.i.v. or 6 mg/day p.o. dexamethasone, or 20-30 mg/day p.o. prednisolone. The median (25th-75th percentile) number of days from the date of onset to glucocorticoid administration was 8.0 days (7.0-11.25 days). While 24 patients were hospitalized, the condition of 14 improved without hospitalization. The median number of days from glucocorticoid administration to hospitalization was 1.0 day (range, 1.0-1.0 day). In the non-hospitalized patients, the median number of days of glucocorticoid administration was 5.0 days (5.0-5.25 days). The mean number of days from glucocorticoid administration to discharge from the care facility for non-hospitalized patients was 8.4 ± 3.3 days. The adverse reactions among non-hospitalized patients included insomnia (n = 1) and mild liver dysfunction (n = 3). The present method of glucocorticoid administration can be safely used for patients with COVID-19 in care facilities.
Refractory Chest Pain in Mild to Moderate Coronavirus Disease 2019 Successfully Treated with Saikanto, a Japanese Traditional Medicine.

Ryutaro Arita, Rie Ono, Natsumi Saito, Satoko Suzuki, Akiko Kikuchi, Minoru Ohsawa, Yasunori Tadano, Tetsuya Akaishi, Takeshi Kanno, Michiaki Abe, Ko Onodera, Shin Takayama, Tadashi Ishii

The Tohoku journal of experimental medicine　257　(3)　241-249　2022/05/20

DOI： 10.1620/tjem.2022.J040 　

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Coronavirus disease 2019 (COVID-19) causes a variety of pain symptoms in the acute phase. Severe chest pain suddenly occurs even without abnormalities on examination and is sometimes refractory to analgesics. Such pain is a clinical concern in care facilities with limited resources, and this is the first report on the use of saikanto for its treatment. In Miyagi Prefecture, Japan, COVID-19 patients with mild symptoms were admitted to a hotel that operated as an isolation facility, and their symptoms were observed. In this article, we report four cases in which chest pain comorbid with mild to moderate COVID-19 was successfully treated with saikanto, a traditional Japanese (Kampo) medicine. The patients presented with chest pain and underwent medical examination at the facility. Two patients had severe chest pain refractory to acetaminophen. Critical cardiopulmonary diseases were ruled out in all the patients, and three patients had features of pneumonia on chest radiograph. Medications, including saikanto, were administered to the patients. The patients' chest pain and other symptoms improved 1-4 days after the administration of saikanto, and they left the care facility without hospitalization. The cause of the chest pain experienced by these patients is unclear, but we speculate that it could be minimal pleural inflammation or neuropathy. Previous pharmacological studies have suggested anti-inflammatory and analgesic properties of the crude drugs that constitute saikanto. This case report suggests that saikanto could be a treatment option for chest pain refractory to analgesics in patients with mild to moderate COVID-19.
The depressive state of COVID-19-free patients seen in a General Medicine Department before and during the outbreak

4　(3)　139-147　2022/05
Predictors of early and late mortality after the treatment for early gastric cancers International-journal

Yohei Ogata, Waku Hatta, Yuki Ohara, Tomoyuki Koike, Hiroko Abe, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Akihiro Yamamura, Naoki Tanaka, Takashi Kamei, Michiaki Unno, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

Digestive Endoscopy　34　(4)　816-825　2022/05
Publisher: Wiley
DOI： 10.1111/den.14172 　

ISSN： 0915-5635

eISSN： 1443-1661

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OBJECTIVES: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately. METHODS: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of 3 years. RESULTS: We enrolled 1439 patients with a median follow-up period of 79 months. The 5-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥85 years (hazard ratio [HR] 2.88 and 4.54, respectively) and Eastern Cooperative Oncology Group Performance Status ≥2 (HR 3.00 and 4.19, respectively). Charlson comorbidity index ≥2 (HR 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥3 (HR 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥0.028 (HR 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR 2.26), intermediate- (HR 2.12)/high-risk (HR 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR 1.70) were predictors for early mortality. CONCLUSION: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality.
The effects of third and fourth dose vaccination in immunocompromised people Systematic review of research studies on immunogenicity, safety, and efficacy/effectiveness of third and fourth dose COVID-19 vaccines in immunocompromised individuals

2022/04/13

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Objectives: Vaccination against COVID-19 may be less efficacious in immunocompromised and dialysis patients who may require booster vaccinations. We evaluated this in a systematic review of the efficacy, immunogenicity, and safety of 3rd and 4th dose vaccines in the immunocompromised and those on dialysis. Design: This was a rapid systematic review and meta-analysis. Methods: Two reviewers assessed studies for eligibility and performed data extraction independently. Proportions were calculated for case series and relative risk for comparative studies with 95% confidence intervals and synthesised using a random effects model. Results: There is approximately a 20% reduction in vaccine efficacy in the immunocompromised compared to the healthy population although overall the vaccine offers 75% protection compared to the immunocompromised that are not vaccinated for the Delta variant. A third vaccine led to a 19% absolute increase in seroconversion with the least absolute increase seen in dialysis patients (9%) and the most in transplant patients (27%). A fourth vaccine resulted in 56% seroconverting who had previously been negative after three vaccinations. There are no safety concerns with COVID-19 vaccinations in the immunocompromised or in dialysis patients. A more detailed summary of the results is given in the table below. Conclusions: Booster COVID-19 vaccination is modestly less efficacious in the immunocompromised and immunogenicity data would suggest transplant patients are particularly vulnerable. A fourth vaccination increases seroconversion.
Recent approach for preventing complications in upper gastrointestinal endoscopic submucosal dissection International-journal

Waku Hatta, Tomoyuki Koike, Hiroko Abe, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

DEN Open　2　(1)　e60　2022/04
Publisher: Wiley
DOI： 10.1002/deo2.60 　

ISSN： 2692-4609

eISSN： 2692-4609

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Although endoscopic submucosal dissection (ESD) is a minimally invasive treatment method for upper gastrointestinal (GI) tumors, patients undergoing upper GI ESD sometimes fall into a serious condition from complications. Thus, it is important to fully understand how to prevent complications when performing upper GI ESD. One of the major complications in esophageal and gastric ESD is intraoperative perforation. To prevent this complication, blind dissection should be avoided. Traction-assisted ESD is a useful technique for maintaining good endoscopic view. This method was proven to reduce the incidence of intraoperative perforation, which would become a standard technique in esophageal and gastric ESD. In gastric ESD, delayed bleeding is the most common complication. Recently, a novel prediction model (BEST-J score) consisting of 10 factors with four risk categories for delayed bleeding in gastric ESD was established, and a free mobile application is now available. For reducing delayed bleeding in gastric ESD, vonoprazan ≥20 mg/day is the sole reliable method in the current status. Duodenal ESD is still challenging with a much higher frequency of complications, such as perforation and delayed bleeding, than ESD in other organs. However, with the development of improved devices and techniques, the frequency of complications in duodenal ESD has been decreasing. To prevent intraoperative perforation, some ESD techniques, such as using the distal tips of the Clutch Cutter, were developed. An endoscopic mucosal defect closure technique would be mandatory for preventing delayed complications. However, several unresolved issues, including standardization of duodenal ESD, remain and further studies are demanded.
食道上皮内腫瘍の病理学的検討

藤島史喜, 國吉真平, 佐藤聡子, 尾形洋平, 齊藤真弘, 菅野武, 八田和久, 小池智幸, 正宗淳, 笹野公伸

胃と腸　57　(3)　243-249　2022/03
Publisher: 株式会社医学書院
DOI： 10.11477/mf.1403202673 　

ISSN： 0536-2180

eISSN： 1882-1219
Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia.

Yasuaki Abe, Waku Hatta, Sho Asonuma, Tomoyuki Koike, Hiroko Abe, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Hironobu Sasano, Atsushi Masamune

Internal medicine (Tokyo, Japan)　61　(16)　2441-2448　2022/02/01

DOI： 10.2169/internalmedicine.8253-21 　

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A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase [please check this carefully]. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up.
Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding International-journal International-coauthorship Peer-reviewed

Takeshi Kanno, Yuhong Yuan, Frances Tse, Colin W Howden, Paul Moayyedi, Grigorios I Leontiadis

Cochrane Database of Systematic Reviews　2022　(1)　2022/01/07
Publisher: Wiley
DOI： 10.1002/14651858.cd005415.pub4 　

eISSN： 1465-1858

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<h4>Background</h4>Upper gastrointestinal (GI) bleeding is a common reason for emergency hospital admission. Proton pump inhibitors (PPIs) reduce gastric acid production and are used to manage upper GI bleeding. However, there is conflicting evidence regarding the clinical efficacy of proton pump inhibitors initiated before endoscopy in people with upper gastrointestinal bleeding.<h4>Objectives</h4>To assess the effects of PPI treatment initiated prior to endoscopy in people with acute upper GI bleeding.<h4>Search methods</h4>We searched the CENTRAL, MEDLINE, Embase and CINAHL databases and major conference proceedings to October 2008, for the previous versions of this review, and in April 2018, October 2019, and 3 June 2021 for this update. We also contacted experts in the field and searched trial registries and references of trials for any additional trials.<h4>Selection criteria</h4>We selected randomised controlled trials (RCTs) that compared treatment with a PPI (oral or intravenous) versus control treatment with either placebo, histamine-2 receptor antagonist (H₂RA) or no treatment, prior to endoscopy in hospitalised people with uninvestigated upper GI bleeding.<h4>Data collection and analysis</h4>At least two review authors independently assessed study eligibility, extracted study data and assessed risk of bias. Outcomes assessed at 30 days were: mortality (our primary outcome), rebleeding, surgery, high-risk stigmata of recent haemorrhage (active bleeding, non-bleeding visible vessel or adherent clot) at index endoscopy, endoscopic haemostatic treatment at index endoscopy, time to discharge, blood transfusion requirements and adverse effects. We used standard methodological procedures expected by Cochrane.<h4>Main results</h4>We included six RCTs comprising 2223 participants. No new studies have been published after the literature search performed in 2008 for the previous version of this review. Of the included studies, we considered one to be at low risk of bias, two to be at unclear risk of bias, and three at high risk of bias. Our meta-analyses suggest that pre-endoscopic PPI use may not reduce mortality (OR 1.14, 95% CI 0.76 to 1.70; 5 studies; low-certainty evidence), and may reduce rebleeding (OR 0.81, 95% CI 0.62 to 1.06; 5 studies; low-certainty evidence). In addition, pre-endoscopic PPI use may not reduce the need for surgery (OR 0.91, 95% CI 0.65 to 1.26; 6 studies; low-certainty evidence), and may not reduce the proportion of participants with high-risk stigmata of recent haemorrhage at index endoscopy (OR 0.80, 95% CI 0.52 to 1.21; 4 studies; low-certainty evidence). Pre-endoscopic PPI use likely reduces the need for endoscopic haemostatic treatment at index endoscopy (OR 0.68, 95% CI 0.50 to 0.93; 3 studies; moderate-certainty evidence). There were insufficient data to determine the effect of pre-endoscopic PPI use on blood transfusions (2 studies; meta-analysis not possible; very low-certainty evidence) and time to discharge (1 study; very low-certainty evidence). There was no substantial heterogeneity amongst trials in any analysis.<h4>Authors' conclusions</h4>There is moderate-certainty evidence that PPI treatment initiated before endoscopy for upper GI bleeding likely reduces the requirement for endoscopic haemostatic treatment at index endoscopy. However, there is insufficient evidence to conclude whether pre-endoscopic PPI treatment increases, reduces or has no effect on other clinical outcomes, including mortality, rebleeding and need for surgery. Further well-designed RCTs that conform to current standards for endoscopic haemostatic treatment and appropriate co-interventions, and that ensure high-dose PPIs are only given to people who received endoscopic haemostatic treatment, regardless of initial randomisation, are warranted. However, as it may be unrealistic to achieve the optimal information size, pragmatic multicentre trials may provide valuable evidence on this topic.
The effects of vaccination in immunocompromised pediatric people Systematic review of research studies on immunogenicity, safety, and efficacy/effectiveness of COVID-19 vaccines in immunocompromised pediatric individuals

2022/01/03
Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma

Shusuke Toda, Waku Hatta, Kiyotaka Asanuma, Naoki Asano, Yoshitaka Ono, Hiroko Abe, Yohei Ogata, Masahiro Saito, Takeshi Kanno, Xiaoyi Jin, Kaname Uno, Tomoyuki Koike, Akira Imatani, Shin Hamada, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

The Tohoku Journal of Experimental Medicine　258　(3)　195-206　2022
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j077 　

ISSN： 0040-8727

eISSN： 1349-3329

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Patients with esophageal squamous cell carcinoma (ESCC) might have a specific mechanism for the carcinogenesis by alcohol consumption in the background esophageal mucosa, and nuclear factor erythroid 2-related factor 2 (NRF2), which plays a protective role against esophageal carcinogenesis, and barrier dysfunction might be associated with this phenomenon. This study aimed to confirm this hypothesis. Twenty patients with superficial ESCCs (ESCC patients) and 20 age- and sex-matched patients without ESCC (non-ESCC patients) were enrolled. Biopsy samples were obtained from non-neoplastic esophageal mucosa: one for histological evaluation, one for quantitative real-time polymerase chain reaction (PCR), and two for the mini-Ussing chamber system to measure transepithelial electrical resistance (TEER) and, thereafter, for PCR. The TEER after acetaldehyde or both acetaldehyde and ethanol exposure did not differ significantly between ESCC and non-ESCC patients. Unlike non-ESCC patients, mRNA levels of NRF2 target genes and claudin4 in ESCC patients tended to decrease after the exposure, with a significant difference between no exposure and both acetaldehyde and ethanol exposure in NRF2 target genes (p < 0.05). Furthermore, in ESCC patients, the decreased tendency of mRNA levels of NRF2 target genes after the exposure was more pronounced in high-risk states, such as aldehyde dehydrogenase 2 (ALDH2) Lys alleles (Glu/Lys + Lys/Lys), Lugol-voiding lesion grade C, and drinking history. In conclusion, the protective role of NRF2 against carcinogenesis from alcohol exposure might be disrupted in the background esophageal mucosa of ESCC patients, which might lead to a high incidence of metachronous ESCC.
Reliability and Validation of the Persian Version of JUICE Study Questionnaire International-journal International-coauthorship

Maryam Rayatpisheh, Saba Nasseri-Moghaddam, Afsoon Kherad, Takeshi Kanno, Ali Reza Sima, Paul Moayyedi, Siavosh Nasseri-Moghaddam

Archives of Iranian Medicine　25　(1)　1-5　2022/01/01
Publisher: Maad Rayan Publishing Company
DOI： 10.34172/aim.2022.01 　

ISSN： 1029-2977

eISSN： 1735-3947

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Background: This study is part of a prospective international cohort study on the composition of microbiota living in the upper gastrointestinal (GI) tract and its correlations to the patients’ symptoms, and their psychological and physical health status in three different populations (JUICE Study). Our study evaluates the reliability and validity of the Persian version of a three-part questionnaire which will be used in this study. Methods: The original English version of the questionnaire was translated to Farsi and then back translated to English by an expert Iranian English teacher. The back-translation was edited by a native English speaker and then retranslated to Farsi. The questionnaire consists of three parts; the first part includes demographic data, the second part is the EQ-5D questionnaire which is an instrument developed by the EuroQol group to measure five dimensions of quality of life and health status, and the third part is the Hospital Anxiety and Depression Scale questionnaire (HADS). By convenience sampling, 22 participants were enrolled. To check reliability, they were asked to complete the questionnaire and repeat this two weeks later. For validity, one of the researchers completed the questionnaire for each of the participants after interviewing them and this was compared with the questionnaire completed by the participant. Each participant was also asked to comment on the content and structure of the questionnaire and these points were considered for improvement of the questionnaire. Results: The first six questions were demographic, and completely the same in the test and retest phases. All of the other questions in the first part of the questionnaire had Kappa values above 0.6 for both reliability and validity. Four questions in this section were assessed with percentage agreement. Percentage agreements were 0.86, 0.54, 0.66 and 0.9 for reliability and 1, 0.81, 0.81 and 1 for validity for the 8th, 12th, 13th and 14th questions, respectively. In the second part, i.e. the EQ5D questionnaire, percentage agreements of the first and second items for reliability equaled 1. Percentage agreements of the three last items were 0.90, 0.63 and 0.72, respectively. Validity of the EQ5D questionnaire was 100% for the first three items and 95% for the last one. For the HADS questionnaire, percentage agreement averaged 0.63 in the reliability phase and 0.78 in the validation phase. Conclusion: According to our data, this three-part questionnaire has acceptable reliability and validity to be used as an instrument in Farsi-speaking populations for the JUICE study.
特集:絶対に見逃してはいけない観察ポイントはこれ! 救急でよく出会う症状・所見16:⑤吐血 ⑥下血・血便

星知恵実, 菅野武

Emer Log エマログ2022年1月号　35　(1)　36-47　2022/01
特発性潰瘍—特集臨床の悩ましい問題をスッキリ解消! 消化性潰瘍治療薬の使い分け ; 病態別にみる消化性潰瘍治療薬の使い方

菅野武, 小池智幸, 正宗淳

月刊薬事 = The pharmaceuticals monthly　63　(14)　2792-2796　2021/11
Publisher: じほう
ISSN： 0016-5980
Linked-color Imaging May Help Improve the Visibility of Superficial Barrett's Esophageal Adenocarcinoma by Increasing the Color Difference

Masahiro Saito, Tomoyuki Koike, Yuki Ohara, Kenichiro Nakagawa, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

Internal Medicine　60　(21)　3351-3358　2021/11/01
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.6674-20 　

ISSN： 0918-2918

eISSN： 1349-7235
特発性潰瘍

菅野武, 小池智幸, 正宗淳

月刊薬事 2021年11月号【特集】臨床の悩ましい問題をスッキリ解消！消化性潰瘍治療薬の使い分け　63　(14)　48-52　2021/11
Prevention of delayed bleeding with vonoprazan in upper gastrointestinal endoscopic treatment.

Hiroko Abe, Waku Hatta, Yohei Ogata, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Kunio Tarasawa, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

Journal of gastroenterology　56　(7)　640-650　2021/07

DOI： 10.1007/s00535-021-01781-4 　

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BACKGROUND: Delayed bleeding is the major adverse event in upper gastrointestinal endoscopic treatment (UGET). We aimed to investigate the efficacy of vonoprazan, which is the novel strong antisecretory agent, to reduce the risk for delayed bleeding in comparison with proton pump inhibitors (PPIs) in UGET. METHODS: This retrospective population-based cohort study used the Diagnosis Procedure Combination database in Japan. We included patients on vonoprazan or PPI in UGET between 2014 and 2019. The primary outcome was delayed bleeding. We conducted propensity score matching to balance the comparison groups, and logistic regression analyses to compare the bleeding outcomes. RESULTS: We enrolled 124,422 patients, in which 34,822 and 89,600 were prescribed with vonoprazan and PPI, respectively. After propensity score matching, the risk for delayed bleeding was lower in vonoprazan than in PPI (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.71-0.80), consistent with sensitivity analysis results. In the subgroup analyses of seven UGET procedures, vonoprazan was significantly advantageous in esophageal endoscopic submucosal dissection (E-ESD) (OR, 0.71; 95% CI, 0.54-0.94) and gastroduodenal endoscopic submucosal dissection (GD-ESD) (OR, 0.70; 95% CI, 0.65-0.75), although correction for multiple testing of the outcome data removed the significance in E-ESD. These results were also consistent with sensitivity analysis results. In the five other procedures, no significant advantage was found. CONCLUSIONS: This nationwide study found that, compared with PPI, vonoprazan can reduce delayed bleeding with approximately 30% in GD-ESD. Vonoprazan has the possibility to become a new treatment method for preventing delayed bleeding in this procedure.
Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series Peer-reviewed

Shin Takayama, Ryutaro Arita, Rie Ono, Natsumi Saito, Satoko Suzuki, Akiko Kikuchi, Minoru Ohsawa, Yasunori Tadano, Tetsuya Akaishi, Junichi Tanaka, Takeshi Kanno, Michiaki Abe, Ko Onodera, Tadashi Ishii

The Tohoku Journal of Experimental Medicine　254　(2)　71-80　2021/06

DOI： 10.1620/tjem.254.71 　

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Olfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory disorder presented with a blocked nose, nasal discharge or taste impairment. Physical examination using Kampo medicine showed similar findings, such as a red tongue with red spots and sublingual vein congestion, which presented as blood stasis and inflammation; thus, we prescribed the Kampo medicine, kakkontokasenkyushin'i. After administration, the numeric rating scale scores of the smell impairment improved within 3 days from 9 to 3 in case 1, from 10 to 0 in case 2, from 9 to 0 in case 3, from 5 to 0 in case 4, and from 9 to 0 within 5 days in case 5. Following the treatment, other common cold symptoms were also alleviated. Kakkontokasenkyushin'i can be used for treating nasal congestion, rhinitis, and inflammation in the nasal mucosa. The olfactory disorder in COVID-19 has been reportedly associated with inflammation and congestion, especially in the olfactory bulb and olfactory cleft. Kakkontokasenkyushin'i may be one of the treatment alternatives for the olfactory disorder with rhinitis in patients with COVID-19.
A Rare Case of Localized Esophageal Amyloidosis.

Taku Fujiya, Waku Hatta, Tomoyuki Koike, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Nagaaki Katoh, Tsuneaki Yoshinaga, Atsushi Masamune

Internal medicine (Tokyo, Japan)　60　(10)　1529-1532　2021/05/15

DOI： 10.2169/internalmedicine.6321-20 　

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A 72-year-old man without any symptoms was referred to our hospital. Esophagogastroduodenoscopy revealed an elevated esophageal lesion that was covered with normal mucosa. The examination of biopsy specimens from the lesion revealed amyloid light-chain (AL) (λ) type amyloid deposits, but there were no amyloid deposits elsewhere in the gastrointestinal tract. Further examinations did not indicate systemic amyloidosis. Thus, this case was diagnosed as a localized esophageal amyloidosis. As the clinical outcome of localized amyloidosis is favorable, this case was scheduled for close follow-up. Localized amyloidosis should be considered in the differential diagnosis of esophageal submucosal tumors.
Restoration of clean water supply and toilet hygiene reduces infectious diseases in post-disaster evacuation shelters: A multicenter observational study International-journal

Tetsuya Akaishi, Kazuma Morino, Yoshikazu Maruyama, Satoru Ishibashi, Shin Takayama, Michiaki Abe, Takeshi Kanno, Yasunori Tadano, Tadashi Ishii

Heliyon　7　(5)　e07044-e07044　2021/05
Publisher: Elsevier BV
DOI： 10.1016/j.heliyon.2021.e07044 　

ISSN： 2405-8440

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After a massive disaster, many residents in affected areas are forced to temporarily stay in evacuation shelters. The exact impact of the state of resource supply and infrastructure in evacuation shelters on the health status of evacuees has not been sufficiently studied. Two weeks after the 2011 Great East Japan Earthquake (GEJE), comprehensive surveillance related to the health status and hygiene level was performed for all evacuation shelters (328 shelters with 46,480 evacuees at the peak) in one of the most devastating medical zones after the tsunami hit the area (Ishinomaki City). The joint relief team regularly visited all evacuation shelters across the area to assess the situation of resource supply levels, infrastructural damage, rapid need of resources, and the health status of the evacuees. In this cross-sectional observational study, we evaluated the relationship between the resource supply levels and health status among evacuees in two time periods (days 14-19 and 20-25). Among the evaluated vital resources, clean tap water supply was among the most disrupted by the disaster, and was not fully restored in most shelters during the assessment period. The cross-sectional relationship between resource supplies and morbidity was inconsistent between the two assessment periods, reflecting the multifactorial nature of health status in evacuation shelters. The clean tap water supply level at the first assessment showed a strong negative correlation with the subsequent prevalence of respiratory or gastrointestinal infectious conditions at the second assessment. Restorations in the clean tap water supply and toilet hygiene correlated each other, and both correlated with a decrease in the prevalence of gastrointestinal infectious conditions. In conclusion, disrupted clean tap water supply and inadequate toilet hygiene after a massive disaster would jointly harm the health status of those in shelters. Prompt assessments using quick visual assessment and restorations of these key resources have validity with suppressed environmental health risks among evacuees.
Lidocaine spray versus viscous lidocaine solution for pharyngeal local anesthesia in upper gastrointestinal endoscopy: Systematic review and meta‐analysis International-journal

Jun Watanabe, Yusuke Ikegami, Ayumi Tsuda, Eiichi Kakehi, Takeshi Kanno, Shizukiyo Ishikawa, Yuki Kataoka

Digestive Endoscopy　33　(4)　538-548　2021/05
Publisher: Wiley
DOI： 10.1111/den.13775 　

ISSN： 0915-5635

eISSN： 1443-1661

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OBJECTIVES: There are two major methods for local anesthesia by lidocaine before upper gastrointestinal endoscopy: simple spray and viscous solution. We aimed to assess the efficacy and safety by meta-analysis between these two methods. METHODS: We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov databases through October 2019 to perform meta-analyses using random-effects models. The primary outcomes were participants' pain/discomfort, satisfaction, and anaphylactic shock. Three reviewers independently searched for articles, extracted data, and assessed the risk of bias. We evaluated the certainty of evidence based on the Grading of Recommendations, Assessment, Development, and Evaluation approach. This study was registered in PROSPERO (CRD42020155611). RESULTS: We included seven randomized controlled trials (2667 participants). The participants' pain/discomfort may be similar between the lidocaine spray and viscous solution [standardized mean difference 0.03, 95% confidence intervals (CI) -0.37 to 0.42; I2 = 93%; low certainty of evidence]. The lidocaine spray probably increased participants' satisfaction compared with the viscous solution (relative risk 1.22; 95% CI, 1.02 to 1.47; I2 = 47%; moderate certainty of evidence). No anaphylactic shock occurred in four studies (low certainty of evidence). Four studies had high risks of selection bias. CONCLUSION: The use of lidocaine spray for local anesthesia provided better satisfaction scores than the viscous solution, and both methods have the same effect with regards to the control of discomfort and pain. Further studies in large multicenter randomized controlled trials with a pre-registration protocol are needed.
Vertical evacuation and acute disaster response: Focusing topics from the experience in Great East Japan earthquake 2011 at Shizugawa public hospital Invited

45　(3)　252-258　2021/03
Evidence-based clinical practice guidelines for peptic ulcer disease 2020 Peer-reviewed

Tomoari Kamada, Kiichi Satoh, Toshiyuki Itoh, Masanori Ito, Junichi Iwamoto, Tadayoshi Okimoto, Takeshi Kanno, Mitsushige Sugimoto, Toshimi Chiba, Sachiyo Nomura, Mitsuyo Mieda, Hideyuki Hiraishi, Junji Yoshino, Atsushi Takagi, Sumio Watanabe, Kazuhiko Koike

Journal of Gastroenterology　56　(4)　303-322　2021/02/23
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00535-021-01769-0 　

ISSN： 0944-1174

eISSN： 1435-5922

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<title>Abstract</title>The Japanese Society of Gastroenterology (JSGE) revised the third edition of evidence-based clinical practice guidelines for peptic ulcer disease in 2020 and created an English version. The revised guidelines consist of nine items: epidemiology, hemorrhagic gastric and duodenal ulcers, <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) eradication therapy, non-eradication therapy, drug-induced ulcers, non<italic>-H. pylori,</italic> and nonsteroidal anti-inflammatory drug (NSAID) ulcers, remnant gastric ulcers, surgical treatment, and conservative therapy for perforation and stenosis. Therapeutic algorithms for the treatment of peptic ulcers differ based on ulcer complications. In patients with NSAID-induced ulcers, NSAIDs are discontinued and anti-ulcer therapy is administered. If NSAIDs cannot be discontinued, the ulcer is treated with proton pump inhibitors (PPIs). Vonoprazan (VPZ) with antibiotics is recommended as the first-line treatment for <italic>H. pylori</italic> eradication, and PPIs or VPZ with antibiotics is recommended as a second-line therapy. Patients who do not use NSAIDs and are <italic>H. pylori</italic> negative are considered to have idiopathic peptic ulcers. Algorithms for the prevention of NSAID- and low-dose aspirin (LDA)-related ulcers are presented in this guideline. These algorithms differ based on the concomitant use of LDA or NSAIDs and ulcer history or hemorrhagic ulcer history. In patients with a history of ulcers receiving NSAID therapy, PPIs with or without celecoxib are recommended and the administration of VPZ is suggested for the prevention of ulcer recurrence. In patients with a history of ulcers receiving LDA therapy, PPIs or VPZ are recommended and the administration of a histamine 2-receptor antagonist is suggested for the prevention of ulcer recurrence.
(第4章)術後合併症の予防と治療逆流性食道炎、胃十二指腸潰瘍

菅野武, 小池智幸, 正宗淳

月刊薬事 2021年2月臨時増刊号【どんな薬剤・合併症・病態・患者背景にも対応できる周術期の薬の使い方パーフェクトガイド】　63　(3)　495-500　2021/02
Publisher: (株)じほう
ISSN： 0016-5980
Somatic symptoms with psychogenic or psychiatric background: Characteristics and pitfalls Peer-reviewed

Tetsuya Akaishi, Michiaki Abe, Atsuko Masaura, Junichi Tanaka, Shin Takayama, Ko Onodera, Takehiro Numata, Kota Ishizawa, Satoko Suzuki, Minoru Ohsawa, Takeshi Kanno, Tadashi Ishii

Journal of Family Medicine and Primary Care　10　(2)　1021-1021　2021/02
Publisher: Medknow
DOI： 10.4103/jfmpc.jfmpc_1100_20 　

ISSN： 2249-4863
Barrett食道腺癌のsurveillance Peer-reviewed

小池智幸, 齊藤真弘, 大原祐樹, 伊丹英昭, 竹内章夫, 大方智樹, 李秀載, 中川健一郎, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

胃と腸　56　(2)　163-173　2021/02
Publisher: (株)医学書院
ISSN： 0536-2180

eISSN： 1882-1219
The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis

Masahiro Saito, Tomoyuki Koike, Yasuaki Abe, Kenichiro Nakagawa, Takeshi Kanno, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Atsushi Masamune

Internal Medicine　60　(3)　391-396　2021/02/01
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.5431-20 　

ISSN： 0918-2918

eISSN： 1349-7235
Predictors of Early and Late Mortality after Endoscopic Resection for Esophageal Squamous Cell Carcinoma. Peer-reviewed

Yohei Ogata, Waku Hatta, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

The Tohoku journal of experimental medicine　253　(1)　29-39　2021/01

DOI： 10.1620/tjem.253.29 　

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In esophageal squamous cell carcinoma (ESCC) comprising 90% of cases with esophageal cancer, endoscopic resection (ER) is recommended for patients with negligible risk of ESCC-related mortality. In fact, a main cause of death in patients underwent ER is not ESCC. We thus aimed to clarify the predictors for early and late mortality among patients underwent ER of ESCC between 2005 and 2018 at our institution. In this retrospective cohort study, we investigated the prognosis and predictors of early and late mortality with the cut-off value of 3 years. We enrolled 407 patients with a median 69 months follow-up. The 5-year overall survival and disease-specific survival, an indicator of ESCC-related mortality, were 83.4% and 98.4%, respectively. In multivariate Cox analyses, Eastern Cooperative Oncology Group performance status (ECOG-PS), consisting of six grades by a patient's level of activity, ≥ 2 was a predictor for early and late morality [hazard ratio (HR), 7.21 (P = 0.007) and 15.62 (P = 0.021), respectively]. Charlson comorbidity index (CCI), which is an index for predicting mortality by comorbid conditions, ≥ 2 was also a predictor for both mortality [HR, 2.97 (P = 0.017) and 1.90 (P = 0.019), respectively]. However, age was a predictor only for late mortality [HR, 3.08 (P = 0.010) in 80-84 years and 8.38 (P < 0.001) in ≥ 85 years]. Considering the predictive ability for early mortality, we propose that ECOG-PS and/or CCI are better indices compared with age in deciding treatment strategy after ER for ESCC.
Localized Gastric Amyloidosis that Displayed Morphological Changes over 10 Years of Observation Peer-reviewed

Yasushi Takahashi, Waku Hatta, Tomoyuki Koike, Yohei Ogata, Taku Fujiya, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Fumiyoshi Fujishima, Nagaaki Katoh, Tsuneaki Yoshinaga, Atsushi Masamune

Internal Medicine　60　(4)　539-543　2021
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.5031-20 　

ISSN： 0918-2918

eISSN： 1349-7235

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We herein report an extremely rare case of localized gastric amyloidosis (LGA) with morphological changes during the follow-up. A 71-year-old woman who had a depressed lesion with central elevation in the gastric lower body was diagnosed with LGA. Esophagogastroduodenoscopy at 10 years after the initial examination showed that the lesion had grown and changed morphologically, exhibiting a submucosal tumor-like appearance. Since the lesion was confined to the submucosa, the patient underwent endoscopic submucosal dissection. The final pathological diagnosis was amyloid light-chain (AL)-type LGA. This case may provide useful information regarding the natural history of AL-type LGA.
Who Needs Gastroprotection in 2020? International-journal International-coauthorship Peer-reviewed

Takeshi Kanno, Paul Moayyedi

Current Treatment Options in Gastroenterology　18　557-573　2020/11/11
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11938-020-00316-9 　

ISSN： 1092-8472

eISSN： 1534-309X
特発性潰瘍：注目すべき非H. pylori非NSAIDsの胃・十二指腸潰瘍

J. New Rem. & Clin.　69　(7)　873-877　2020/07
Publisher:
ISSN： 0559-8672
Barrett食道癌の診断

小池智幸, 齊藤真弘, 大原祐樹, 大方智樹, 阿部泰明, 中川健一郎, 金笑奕, 菅野武, 八田和久, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 菊地亮介, 猪股芳文, 正宗淳

胃と腸　55　(5)　514-529　2020/05
Prevalence and risk factors for lymph node metastasis after noncurative endoscopic resection for early gastric cancer: a systematic review and meta-analysis. International-coauthorship Peer-reviewed

Waku Hatta, Takuji Gotoda, Takeshi Kanno, Yuhong Yuan, Tomoyuki Koike, Paul Moayyedi, Atsushi Masamune

Journal of gastroenterology　55　(8)　742-753　2020/04/10

DOI： 10.1007/s00535-020-01685-9 　

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BACKGROUND: Additional surgery for all patients with noncurative resection after endoscopic resection (ER) for early gastric cancer (EGC) may be excessive due to the relatively low rate of lymph node metastasis (LNM) in such patients. However, the prevalence and risk factors for LNM after noncurative ER have not been consistent across studies. METHODS: We performed a systematic review of electronic databases through August 10, 2018 to identify cohort studies with patients who underwent additional surgery after noncurative ER for EGC. The prevalence of LNM in such patients was extracted for all studies. Odds ratios (ORs) were combined using random-effects meta-analyses to assess the risk of LNM, when possible. RESULTS: We identified 24 studies comprising 3877 patients with 311 having LNM (pooled prevalence, 8.1%). The risk of LNM was significantly increased in lymphatic invasion (OR [95% confidence interval] = 4.22 [2.88-6.19]), lymphovascular invasion (LVI) (4.17 [2.90-5.99]), vascular invasion (2.38 [1.65-3.44]), positive vertical margin (2.16 [1.59-2.93]), submucosal invasion depth of ≥ 500 μm (2.14 [1.48-3.09]), and tumor size > 30 mm (1.77 [1.31-2.40]). In contrast, there was no significant association between undifferentiated-type or ulceration (scar) and LNM. When studies were restricted to those that evaluated the adjusted OR, the risk of vascular invasion for LNM did not reach statistical significance. CONCLUSIONS: Several pathological factors, most notably lymphatic invasion and LVI, were associated with LNM in patients with noncurative resection after ER for EGC. Lymphatic and vascular invasion should be assessed separately instead of LVI (PROSPERO CRD42018109996).
Clarithromycin Versus Metronidazole in First-Line Helicobacter Pylori Triple Eradication Therapy Based on Resistance to Antimicrobial Agents: Meta-Analysis. International-journal Peer-reviewed

Masaki Murata, Mitsushige Sugimoto, Hitomi Mizuno, Takeshi Kanno, Kiichi Satoh

Journal of clinical medicine　9　(2)　2020/02/17

DOI： 10.3390/jcm9020543 　

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BACKGROUND: International treatment guidelines for Helicobacter pylori infection recommend a proton pump inhibitor (PPI)/amoxicillin/clarithromycin (CAM) regimen (PAC) or PPI/amoxicillin/metronidazole (MNZ) regimen (PAM) as first-line therapy based on culture and sensitivity testing. As incidence rates of antimicrobial agent-resistant strains are changing year by year, it is important to reevaluate the efficacy of eradication regimens. We performed a meta-analysis to evaluate the efficacy and safety of PAC and PAM based on different locations categorized by the reported incidence of CAM- and MNZ-resistant strains. METHODS: Randomized control trials (RCTs) comparing eradication rates between PAC and PAM first-line treatment up to December 2018 were included. We divided RCTs into four groups based on resistance to CAM (< 15% or ≥ 15%) and MNZ (< 15% or ≥ 15%). RESULTS: A total of 27 studies (4825 patients) were included. Overall eradication rates between PAC and PAM were similar (74.8% and 72.5%, relative risk (RR): 1.13, 95% confidence interval (CI): 0.91-1.39, P = 0.27) in the intention-to-treat analysis. In areas with low MNZ- and high CAM-resistance rates, PAM had a significantly higher eradication rate than PAC (92.5% vs. 70.8%, RR: 0.29, 95% CI: 0.13-0.68). In areas with high MNZ- and low CAM-resistance rates, the eradication rate with PAC was only 72.9%. CONCLUSIONS: Overall eradication rates with PAC and PAM were equivalent worldwide. In low MNZ-resistance areas, PAM may be recommended as first-line therapy. However, the efficacy of PAC may be insufficient, irrespective of susceptibility to CAM.
Strong Intra-Esophageal Reflux May Contribute to the Development of Barrett’s Adenocarcinoma and Affect the Localization International-journal

Masahiro Saito, Tomoyuki Koike, Kenichiro Nakagawa, Yasuaki Abe, Kazuaki Norita, Hiroki Kikuchi, Takeshi Kanno, Waku Hatta, Nobuyuki Ara, Kaname Uno, Kiyotaka Asanuma, Naoki Asano, Akira Imatani, Tooru Shimosegawa, Atsushi Masamune

Digestion　101　(6)　752-760　2020
Publisher: S. Karger AG
DOI： 10.1159/000502377 　

ISSN： 0012-2823

eISSN： 1421-9867

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<b><i>Background:</i></b> There has been no study that has directly measured the esophageal reflux factors in Barrett’s adenocarcinoma (BA) using 24-h multichannel intraluminal impedance-pH monitoring (24-h MII-pH). We aimed to clarify the esophageal reflux factors in Barrett’s esophagus (BE) and BA and the factors that determine the location of BA with 24-h MII-pH. <b><i>Methods:</i></b> We performed 24-h MII-pH in 26 patients with superficial BA treated endoscopically (BA group) and 13 patients with BE (BE group) and examined the esophageal reflux factors (esophageal acid exposure time [AET], bolus exposure (acid, weakly acid, and alkaline), and number of reflux episodes. In the BA group, there were 16 cases in which the lesions were localized in an area in contact with the esophagogastric junction (EGJ; EGJ group), and 10 cases in which the lesions were proximal to the BE and separated from the EGJ (non-EGJ group). <b><i>Results:</i></b> Total reflux in the bolus exposure in the BA group showed higher values compared to that in the BE group. The total of acid and weakly acid reflux of bolus exposure was significantly higher in the BA group than that in the BE group. The BA group also had greater numbers of total reflux episodes than the BE group. As for the cancer locations in BE, the cases in which the lesions were located proximally and separated from the EGJ had more AET and total reflux and acid reflux indicated by bolus exposure compared to the lesions adjacent to the EGJ. <b><i>Conclusions:</i></b> Stronger gastro-esophageal reflux appeared to be an important factor in the development of adenocarcinoma from BE. In addition, the cancer location in BE may be related to the intensity of esophageal reflux.
Proton Pump Inhibitors in the Elderly, Balancing Risk and Benefit: an Age-Old Problem Peer-reviewed

Takeshi Kanno

Current Gastroenterology Reports　21　(12)　2019/12

DOI： 10.1007/s11894-019-0732-3 　

ISSN： 1534-312X
Editorial: the overlap between dyspepsia and gastro-oesophageal reflux-is duodenal eosinophilia the missing link? Peer-reviewed

Kanno T, Moayyedi P

Aliment Pharmacol Ther. 2019 Aug;50(4):454-455.　50　(4)　2019/08

DOI： 10.1111/apt.15388 　

ISSN： 0269-2813
Imipramine for functional dyspepsia: a 60-year journey Peer-reviewed

Kanno, T., Moayyedi, P.

The Lancet Gastroenterology and Hepatology　3　(12)　2018/12

DOI： 10.1016/S2468-1253(18)30338-8 　

ISSN： 2468-1253
The Use of Higher Dose Steroids Increases the Risk of Rebleeding After Endoscopic Hemostasis for Peptic Ulcer Bleeding. International-journal Peer-reviewed

Kondo Y, Hatta W, Koike T, Takahashi Y, Saito M, Kanno T, Asanuma K, Asano N, Imatani A, Masamune A

Digestive diseases and sciences　63　(11)　3033-3040　2018/11

DOI： 10.1007/s10620-018-5209-y 　

ISSN： 0163-2116

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BACKGROUND: Previous studies have shown that several factors such as hemodynamic instability at admission are risk factors for rebleeding of peptic ulcer bleeding. However, whether steroid use increases the risk of rebleeding remains elusive. AIMS: This study aimed to clarify the risk factors for rebleeding after endoscopic hemostasis for peptic ulcer bleeding. METHODS: A total of 185 patients who underwent endoscopic hemostasis for peptic ulcer bleeding at our institution between 2005 and 2017 were retrospectively analyzed. We evaluated factors, including comorbid conditions, in-hospital onset, and steroid use, associated with rebleeding by logistic regression analysis. In addition, we investigated the association between the dose of steroids and rebleeding. RESULTS: The rebleeding rate after endoscopic hemostasis for peptic ulcer bleeding was 14.6%. In the multivariate analysis, the independent risk factors for rebleeding were steroid use (odds ratio 4.56, p = 0.015), multiple ulcers (4.43, p = 0.005), number of comorbidities ≥ 3 3.18, p = 0.026), hemodynamic instability (3.06, p = 0.039), and number of comorbidities ≥ 3 (2.93, p = 0.047). Furthermore, the use of higher dose steroids (≥ 20 mg per day in prednisolone; 10.55, p = 0.002), but not lower dose (< 20 mg per day in prednisolone), was an independent risk factor for rebleeding in the multivariate analysis. The relationship between steroid use and rebleeding was observed in a dose-dependent manner (p for trend = 0.002). CONCLUSIONS: This study first revealed that using higher dose steroids was an independent risk factor for rebleeding after endoscopic hemostasis for peptic ulcer bleeding, with a dose-response relation.
救急医療における医歯薬連携救急・災害医療における医歯薬連携東日本大震災における医科歯科保健対策被災した医療者としての視点,災害時受援体制の構築と課題南三陸町の事例を通して

菅野武

救急医学　42　(8)　931‐940　2018/08

ISSN： 0385-8162
好酸球性食道炎の診断と治療好酸球性食道炎の画像診断内視鏡診断

浅野直喜, 小池智幸, 菅野武, 八田和久, 淺沼清孝, 宇野要, 今谷晃, 下瀬川徹

胃と腸　53　(3)　291-298　2018/03
Publisher: (株)医学書院
DOI： 10.11477/mf.1403201302 　

ISSN： 0536-2180

eISSN： 1882-1219
gNET―アップデート十二指腸neuroendocrine tumor(G1,G2)の診断と治療

八田和久, 小池智幸, 高橋貴一, 菅野武, 荒誠之, 淺沼清孝, 浅野直喜, 今谷晃, 下瀬川徹

月刊消化器・肝臓内科　2　(5)　489-495　2017/11
Publisher: (有)科学評論社
ISSN： 2432-3446
The slow progressive nature of duodenal neuroendocrine tumor: a case report of long-term observation over 14 years Peer-reviewed

Takahashi K, Hatta W, Koike T, Kanno T, Ara N, Asanuma K, Asano N, Imatani A, Fujishima F, Sasano H, Shimosegawa T

Clinical Journal of Gastroenterology　10　(5)　469-473　2017/10

DOI： 10.1007/s12328-017-0758-8 　

ISSN： 1865-7257
Gastric Ulcers with Neither Helicobacter pylori Infection nor Non-steroidal Anti-inflammatory Drugs

菅野武, 飯島克則, 小池智幸, 八田和久, 荒誠之, 淺沼清孝, 浅野直喜, 今谷晃, 下瀬川徹

胃と腸　52　(7)　900-906　2017/06
Publisher: (株)医学書院
DOI： 10.11477/mf.1403201104 　

ISSN： 0536-2180

eISSN： 1882-1219
non‐H.pylori,non‐NSAID潰瘍(ストレス潰瘍)

菅野武, 飯島克則, 小池智幸, 八田和久, 荒誠之, 淺沼清孝, 浅野直喜, 今谷晃, 下瀬川徹

日本ヘリコバクター学会誌　19　(1)　8-11　2017/05
Publisher: (一社)日本ヘリコバクター学会
ISSN： 2187-8005
Notch1 directly induced CD133 expression in human diffuse type gastric cancers Peer-reviewed

Hidetomo Konishi, Naoki Asano, Akira Imatani, Osamu Kimura, Yutaka Kondo, Xiaoyi Jin, Takeshi Kanno, Waku Hatta, Nobuyuki Ara, Kiyotaka Asanuma, Tomoyuki Koike, Tooru Shimosegawa

ONCOTARGET　7　(35)　56598-56607　2016/08

DOI： 10.18632/oncotarget.10967 　

ISSN： 1949-2553
Helicobacter pylori-negative and non-steroidal anti-inflammatory drugs-negative idiopathic peptic ulcers show refractoriness and high recurrence incidence: Multicenter follow-up study of peptic ulcers in Japan Peer-reviewed

Takeshi Kanno, Katsunori Iijima, Yasuhiko Abe, Makoto Yagi, Sho Asonuma, Motoki Ohyauchi, Hirotaka Ito, Tomoyuki Koike, Tooru Shimosegawa

DIGESTIVE ENDOSCOPY　28　(5)　556-563　2016/07

DOI： 10.1111/den.12635 　

ISSN： 0915-5635

eISSN： 1443-1661
高齢者における消化管疾患の低侵襲治療と診断 Seminar 3.成因を意識した消化性潰瘍診療

菅野武, 小池智幸, 下瀬川徹

Geriatric Medicine　54　(4)　347‐351-351　2016/04
Publisher:
ISSN： 0387-1088
Preferential location of idiopathic peptic ulcers Peer-reviewed

Katsunori Iijima, Takeshi Kanno, Yasuhiko Abe, Makoto Yagi, Sho Asonuma, Motoki Ohyauchi, Hirotaka Ito, Tomoyuki Koike, Tooru Shimosegawa

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY　51　(7)　782-787　2016

DOI： 10.3109/00365521.2016.1141316 　

ISSN： 0036-5521

eISSN： 1502-7708
[Relationship between disaster stress and peptic ulcers].

Kanno T, Iijima K, Koike T, Shimosegawa T

Nihon rinsho. Japanese journal of clinical medicine　73　(7)　1209-1214　2015/07
Publisher:
ISSN： 0047-1852
酸関連疾患 III.酸関連疾患治療薬の有用性酸関連疾患治療の最新動向

小池智幸, 中川健一郎, 菅野武, 飯島克則, 下瀬川徹

日本臨床　73　(7)　1136-1146　2015/07
Publisher:
ISSN： 0047-1852
A multicenter prospective study on the prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drugs-negative idiopathic peptic ulcers in Japan. Peer-reviewed

Kanno T, Iijima K, Abe Y, Yagi M, Asonuma S, Ohyauchi M, Ito H, Koike T, Shimosegawa T

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　30　(5)　842-848　2015/05

DOI： 10.1111/jgh.12876 　

ISSN： 0815-9319

eISSN： 1440-1746
Accommodation in a refugee shelter as a risk factor for peptic ulcer bleeding after the Great East Japan Earthquake: a case-control study of 329 patients. Peer-reviewed

Kanno T, Iijima K, Koike T, Abe Y, Shimada N, Hoshi T, Sano N, Ohyauchi M, Ito H, Atsumi T, Konishi H, Asonuma S, Shimosegawa T

J Gastroenterol. 2015 Jan;50(1):31-40　50　(1)　31-40　2015/01

DOI： 10.1007/s00535-014-0940-4 　

ISSN： 0944-1174

eISSN： 1435-5922
東日本大震災を通して、私たちが残せるものとは何か

菅野武

公衆衛生情報みやぎ　443　1-6　2015
A Case of Paralytic Ileus Associated with the Administration of Linagliptin in a Diabetic Patient without a History of Abdominal Surgery Peer-reviewed

Utsumi Sayaka, Kanno Takeshi, Ootomo Masataka

Journal of the Japan Diabetes Society　57　(11)　826-829　2014/11
Publisher: 一般社団法人日本糖尿病学会
DOI： 10.11213/tonyobyo.57.826 　

ISSN： 0021-437X
東日本大震災における4つの被害―宮城県南三陸町の事例からの考察 Peer-reviewed

牧信行, 菅野武, 西澤匡史

日本老年医学会雑誌　51　(3)　286-286　2014/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
[The 41st Scientific Meeting: perspectives of internal medicine lessons from the disaster of the Great East Japan earthquake; 3. Medical disease learned from the Great East Japan earthquake--feature, treatment and prevention--; 3) Digestive diseases].

Iijima K, Kanno T, Koike T, Shimosegawa T

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine　103　(3)　557-560　2014/03
Publisher: The Japanese Society of Internal Medicine
DOI： 10.2169/naika.103.557 　

ISSN： 0021-5384
高齢者消化管疾患の現状と対策高齢者における消化性潰瘍と心因性ストレスとの関連―東日本大震災前後の集計結果から―

飯島克則, 菅野武, 小池智幸, 下瀬川徹

月刊消化器内科　58　(1)　22-23　2014/01/28
Publisher: (有)科学評論社
ISSN： 1884-2895
Helicobacter pylori-negative, non-steroidal anti-inflammatory drug: Negative idiopathic ulcers in Asia Peer-reviewed

Katsunori Iijima, Takeshi Kanno, Tomoyuki Koike, Tooru Shimosegawa

WORLD JOURNAL OF GASTROENTEROLOGY　20　(3)　706-713　2014/01

DOI： 10.3748/wjg.v20.i3.706 　

ISSN： 1007-9327

eISSN： 2219-2840
Peptic ulcers after the Great East Japan earthquake and tsunami: possible existence of psychosocial stress ulcers in humans Peer-reviewed

Takeshi Kanno, Kastunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Norihiro Shimada, Tatsuya Hoshi, Nozomu Sano, Motoki Ohyauchi, Hirotaka Ito, Tomoaki Atsumi, Hidetomo Konishi, Sho Asonuma, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY　48　(4)　483-490　2013/04

DOI： 10.1007/s00535-012-0681-1 　

ISSN： 0944-1174
Hemorrhagic ulcers after Great East Japan Earthquake and Tsunami: features of post-disaster hemorrhagic ulcers. Peer-reviewed

Kanno T, Iijima K, Abe Y, Koike T, Shimada N, Hoshi T, Sano N, Ohyauchi M, Ito H, Atsumi T, Konishi H, Asonuma S, Shimosegawa T

Digestion　87　(1)　40-46　2013/01

DOI： 10.1159/000343937 　

ISSN： 0012-2823
震災医療―来るべき日への医療者としての対応《急性期が過ぎた後に顕在化してくる病態》消化管出血

菅野武, 飯島克則, 小池智幸, 下瀬川徹

内科　110　(6)　999-1003　2012/12
Publisher: (株)南江堂
ISSN： 0022-1961

eISSN： 2432-9452
特異的な脳CT像を呈したエチレングリコール中毒の1例 Peer-reviewed

菅野武, 山田康雄, 乙供茂, 大平祐己, 洞口潔, 上之原広司, 鈴木靖士

日本救急医学会雑誌　17　(8)　491-491　2006/08
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

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Misc. 89

表在型Barrett食道癌の発見契機と特徴に関する検討

小泉薫, 齊藤真弘, 小池智幸, 谷地一真, 首藤千博, 皆瀬ゆみ子, 畑山裕, 尾形洋平, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器がん検診学会雑誌　62　(Suppl大会)　744-744　2024/10
Publisher: (一社)日本消化器がん検診学会
ISSN： 1880-7666

eISSN： 2185-1190
Establishment of a Collaborative System for Long COVID Brain Fog Using a Questionnaire and Scoring

Rie Ono, Shin Takayama, Taizen Nakase, Akiko Kikuchi, Ryutaro Arita, Michiaki Abe, Takeshi Kannno, Ko Onodera, Minoru Osawa, Kota Ishizawa, Natsumi Saito, Tadashi Ishii

An Official Journal of the Japan Primary Care Association　47　(3)　120-123　2024/09/20
Publisher: The Japan Primary Care Association
DOI： 10.14442/generalist.47.120 　

ISSN： 2185-2928

eISSN： 2187-2791
胃瘻抜去後の瘻孔閉鎖不全に対してOTSCが有用であった一例

小笠原光矢, 金笑奕, 小池智幸, 畑山裕, 尾形洋平, 齊藤真弘, 菅野武, 八田和久, 宇野要, 正宗淳

PEG・在宅医療学会学術集会プログラム抄録集　28回　79-79　2024/09
Publisher: PEG・在宅医療学会
若手消化器内視鏡専門医からのメッセージ胃NETのRindi分類におけるリンパ節転移リスクメタ解析による検討

尾形洋平, 八田和久, 菅野武, 小池智幸, 正宗淳

日本消化器内視鏡学会東北支部例会　172回　55-55　2024/07
Publisher: 日本消化器内視鏡学会-東北支部
サルコイドーシス関連縦隔リンパ節腫脹により食道通過障害をきたした一例

大塚哲也, 宇野要, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 小池智幸, 正宗淳

日本消化器内視鏡学会東北支部例会　172回　83-83　2024/07
Publisher: 日本消化器内視鏡学会-東北支部
出血性ショックをきたし血管内治療を要した食道胃粘膜下血腫の1例

皆瀬ゆみ子, 宇野要, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 今谷晃, 小池智幸, 正宗淳

日本消化器内視鏡学会東北支部例会　172回　85-85　2024/07
Publisher: 日本消化器内視鏡学会-東北支部
胆膵内視鏡室の効率的な運用,リスクマネージメントと課題 ERCP/ESTシミュレータ学習はリスク低減に寄与できるか新規モデル開発と教育介入研究

畑山裕, 菅野武, 滝川哲也, 池田未緒, 佐野貴紀, 松本諒太郎, 三浦晋, 濱田晋, 粂潔, 菊田和宏, 正宗淳

膵臓　39　(3)　A301-A301　2024/07
Publisher: (一社)日本膵臓学会
ISSN： 0913-0071

eISSN： 1881-2805
術前確定診断が困難であったEBV関連リンパ球浸潤胃癌の一例

丹野尚太郎, 八田和久, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　217回　91-91　2024/07
Publisher: 日本消化器病学会-東北支部
H.pylori感染状態とディスペプシアの頻度成人胃がん検診事業データに基づく疫学的分析

菅野武, 鈴木直生, 小池智幸, 千葉隆士, 淺沼清孝, 加藤勝章, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本ヘリコバクター学会学術集会プログラム・抄録集　30回　110-110　2024/06
Publisher: (一社)日本ヘリコバクター学会
良質な消化器内視鏡医を育てる教育とは? 侵襲的内視鏡手技に対する教育と評価新規シミュレータ開発を通して明確となった課題

菅野武, 小池智幸, 正宗淳

Gastroenterological Endoscopy　66　(Suppl.1)　842-842　2024/04
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
消化器疾患における腸内細菌叢の解析;病態解明と診療展開食道胃接合部癌発育伸展におけるdysbiosis・腸管粘膜バリア傷害の役割

須藤洸一郎, 宇野要, 玉原亨, 草野啓介, 田邊瑞樹, 菅野武, 浅野直喜, 小池智幸, 正宗淳

日本消化器病学会雑誌　121　(臨増総会)　A44-A44　2024/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
一般成人におけるディスペプシアの疫学と内視鏡所見がん検診事業のデータから

鈴木直生, 菅野武, 小池智幸, 千葉隆士, 淺沼清孝, 加藤勝章, 尾形洋平, 齊藤真弘, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会雑誌　121　(臨増総会)　A350-A350　2024/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
ボノプラザン投与により軽快したHypercontractile esophagusの一例

小泉薫, 齊藤真弘, 小池智幸, 谷地一真, 首藤千博, 皆瀬ゆみ子, 尾形洋平, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器内視鏡学会東北支部例会　171回　95-95　2024/02
Publisher: 日本消化器内視鏡学会-東北支部
内視鏡的粘膜下層剥離術を施行した粘膜内限局リンパ球浸潤胃癌の一例

丹野尚太郎, 尾形洋平, 八田和久, 小池智幸, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 浅野直喜, 今谷晃, 正宗淳, 山崎有人, 藤島史喜

日本消化器内視鏡学会東北支部例会　171回　97-97　2024/02
Publisher: 日本消化器内視鏡学会-東北支部
シミュレータ学習プログラムは安全なESTの達成および自覚的習熟度の向上に寄与する前向き教育介入研究

畑山裕, 菅野武, 滝川哲也, 松本諒太郎, 齊藤真弘, 金笑奕, 三浦晋, 八田和久, 濱田晋, 宇野要, 粂潔, 菊田和宏, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

Gastroenterological Endoscopy　65　(Suppl.2)　2026-2026　2023/10
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
検診で発見されたBarrett食道腺癌の臨床病理学的特徴

谷地一真, 齊藤真弘, 小池智幸, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器がん検診学会雑誌　61　(Suppl総会)　475-475　2023/06
Publisher: (一社)日本消化器がん検診学会
ISSN： 1880-7666

eISSN： 2185-1190
検診にて発見された非機能性十二指腸NETに対してEMROにて断端陰性切除となった一例

鈴木直生, 八田和久, 小池智幸, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器がん検診学会雑誌　61　(Suppl総会)　476-476　2023/06
Publisher: (一社)日本消化器がん検診学会
ISSN： 1880-7666

eISSN： 2185-1190
胃がん2次検診で胃粘膜下腫瘍が疑われ,難治性特発性胃潰瘍であった一例

川邉誠, 菅野武, 小野義高, 宇野要, 小池智幸, 正宗淳

日本消化器がん検診学会雑誌　61　(Suppl総会)　476-476　2023/06
Publisher: (一社)日本消化器がん検診学会
ISSN： 1880-7666

eISSN： 2185-1190
COVID-19軽症者等療養施設におけるモルヌピラビルの効果と安全性

有田龍太郎, 高山真, 阿部倫明, 菊地章子, 大澤稔, 小野寺浩, 菅野武, 齊藤奈津美, 赤石哲也, 小野理恵, 只野恭教, 鈴木聡子, 菅原章人, 石井正

日本プライマリ・ケア連合学会学術大会　14回　219-219　2023/05
Publisher: (一社)日本プライマリ・ケア連合学会
災害医療人材教育におけるオンライン型実習の実際と課題

菅野武, 只野恭教, 阿部喜子, 藤田基生, 西岡貴志, 今井浩之, 佐々木宏之, 江川新一, 島田二郎, 石井正

Japanese Journal of Disaster Medicine　27　(Suppl.2)　385-385　2023/04
Publisher: (一社)日本災害医学会
ISSN： 2189-4035

eISSN： 2434-4214
好酸球性消化管疾患の診断と治療腹部症状と内視鏡所見の乖離無症候性好酸球浸潤例を含む9例の胃・十二指腸好酸球浸潤症例の検討

菅原英之, 菅野武, 正宗淳

日本消化器病学会雑誌　120　(臨増総会)　A67-A67　2023/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
DOAC服用患者における上部消化管ESD後出血と脳梗塞

小野義高, 八田和久, たら澤邦男, 阿部寛子, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 浅野直喜, 小池智幸, 藤森研司, 伏見清秀, 正宗淳

日本消化器病学会雑誌　120　(臨増総会)　A307-A307　2023/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
十二指腸血管拡張症からの難治性出血を契機に後天性血友病を診断・治療しえた1例

阿部寛子, 齊藤真弘, 宇野要, 金笑奕, 菅野武, 八田和久, 浅野直喜, 小池智幸, 今谷晃, 正宗淳, 市川聡

日本消化器内視鏡学会東北支部例会　169回　108-108　2023/02
Publisher: 日本消化器内視鏡学会-東北支部
Excessive supragastric belchingの1例

首藤千博, 小池智幸, 伊丹英昭, 谷地一真, 大原祐樹, 齊藤真弘, 中川健一郎, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　214回　75-75　2023/02
Publisher: 日本消化器病学会-東北支部
胃と十二指腸の潰瘍再発しやすい「特発性」

菅野武

読売新聞医療ルネサンスNo.7722　17　2022/03/09
語り継ぐ震災今、あなたと共に

菅野武

ロータリーの友　70　(3)　4-7　2022/03
食道扁平上皮癌患者の背景食道非腫瘍粘膜におけるアルコール曝露後のNRF2標的遺伝子発現低下

外田修裕, 八田和久, 正宗淳, 淺沼清孝, 浅野直喜, 齊藤真弘, 金笑奕, 菅野武, 小池智幸, 今谷晃

日本消化器病学会雑誌(Web)　119　2022

ISSN： 1349-7693
難治性食道狭窄を呈した微小ガストリノーマの1例

草野啓介, 宇野要, 小池智幸, 三浦晋, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 浅野直喜, 今谷晃, 正宗淳, 益田邦洋, 大塚英郎, 海野倫明, 藤島史喜, 中堀昌人

日本消化器病学会東北支部例会誌　212th　2022
Prevention of delayed bleeding with P-CAB in upper gastrointestinal endoscopic treatment

阿部寛子, 八田和久, たら澤邦男, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

日本消化管学会雑誌(CD-ROM)　6　(Supplement)　2022

ISSN： 2433-3840
内視鏡的に完全切除した胃平滑筋肉腫の一例

谷地一真, 八田和久, 小池智幸, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 浅野直喜, 今谷晃, 渡邊裕文, 藤島史喜, 正宗淳

日本消化器病学会東北支部例会誌　212th　2022
今を生き、明日へとつなごう：自己実現と忘己利他のあいだで Invited

菅野武

未来の地域医療を支えるために～自治医科大学創立50周年記念提言集～　130-135　2021/12
Rapid Review on the Effects of Vaccination in the Immunocompromised and those on Dialysis

2021/10/15

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The SPOR Evidence Alliance (SPOR EA) is supported by the Canadian Institutes of Health Research (CIHR) under the Strategy for Patient-Oriented Research (SPOR) initiative. COVID-19 Evidence Network to support Decision-making (COVID-END) is supported by the Canadian Institutes of Health Research (CIHR) through the Canadian 2019 Novel Coronavirus (COVID-19) Rapid Research Funding opportunity.
40年に及ぶ疫学的評価による本邦における食道胃接合部腺癌、食道腺癌の増加

畑山裕, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 金村政輝, 正宗淳

日本消化器病学会雑誌　118　(臨増大会)　A738-A738　2021/10
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
GERDの診断・病態・治療の最新の知見 Postprandial HRIMにおける胃食道逆流の検討

伊丹英昭, 中川健一郎, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

日本食道学会学術集会プログラム・抄録集　75回　15-15　2021/09
Publisher: (NPO)日本食道学会
表在型Barrett食道腺癌に対するLCIの視認性に関する検討

大原祐樹, 齊藤真弘, 小池智幸, 阿部寛子, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本食道学会学術集会プログラム・抄録集　75回　132-132　2021/09
Publisher: (NPO)日本食道学会
新時代の遠隔ハンズオンセミナー内視鏡的止血術に対する、新規ドライシミュレータを用いたオンラインハンズオンスキルセミナーへの挑戦

菅野武, 畑山裕, 荒田悠太郎, 小池智幸, 正宗淳, 石井正

医学教育　52　(Suppl.)　20-20　2021/07
Publisher: (一社)日本医学教育学会
ISSN： 0386-9644
新規内視鏡シミュレーターを用いた、消化管止血術学習プログラムによる教育介入研究

畑山裕, 菅野武, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A329-A329　2021/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
Helicobacter pylori感染による分化制御遺伝子Notch1の発現抑制を介した胃粘膜萎縮機序の解明

金笑奕, 浅野直喜, 今谷晃, 齋藤方志, 竹内章夫, 斉藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A330-A330　2021/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
歯周病菌リポ多糖類刺激によるピロリ菌除菌療法後の胃粘膜バリア傷害の検討

織内優好, 宇野要, 李秀載, 齊藤真弘, 中川健一郎, 金笑奕, 菅野武, 八田和久, 浅野直喜, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A332-A332　2021/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
Barrett食道腺癌の周在性に関する食道内逆流因子と基線値の検討

大原祐樹, 齊藤真弘, 小池智幸, 中川健一郎, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A345-A345　2021/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
新規内視鏡シミュレーターを用いた、消化管止血術学習プログラムによる教育介入研究

畑山裕, 菅野武, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A329-A329　2021/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
Helicobacter pylori感染による分化制御遺伝子Notch1の発現抑制を介した胃粘膜萎縮機序の解明

金笑奕, 浅野直喜, 今谷晃, 齋藤方志, 竹内章夫, 斉藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A330-A330　2021/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
歯周病菌リポ多糖類刺激によるピロリ菌除菌療法後の胃粘膜バリア傷害の検討

織内優好, 宇野要, 李秀載, 齊藤真弘, 中川健一郎, 金笑奕, 菅野武, 八田和久, 浅野直喜, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A332-A332　2021/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
Barrett食道腺癌の周在性に関する食道内逆流因子と基線値の検討

大原祐樹, 齊藤真弘, 小池智幸, 中川健一郎, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会雑誌　118　(臨増総会)　A345-A345　2021/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
胃十二指腸ESDにおけるP-CABの後出血予防効果 propensity scoreを用いたデータベース解析

阿部寛子, 八田和久, たら澤邦男, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 中川健一郎, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　210回　45-45　2021/02
Publisher: 日本消化器病学会-東北支部
胃十二指腸ESDにおけるP-CABの後出血予防効果 propensity scoreを用いたデータベース解析

阿部寛子, 八田和久, たら澤邦男, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 中川健一郎, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　210回　45-45　2021/02
Publisher: 日本消化器病学会-東北支部
COVID-19軽症者療養施設医療対応のための検査体制とその有用性

高山真, 小野理恵, 有田龍太郎, 齊藤奈津美, 鈴木聡子, 只野恭教, 赤石哲也, 田中淳一, 菅野武, 菊地章子, 大澤稔, 小野寺浩, 阿部倫明, 井戸敬介, 稲葉洋平, 中村直毅, 中山雅晴, 石井正

日本病院総合診療医学会雑誌(Web)　17　2021

ISSN： 2185-8136
歯周病菌リポ多糖類刺激によるピロリ菌除菌療法後の胃粘膜バリア傷害の検討

織内優好, 宇野要, 李秀載, 齊藤真弘, 中川健一郎, 金笑奕, 菅野武, 八田和久, 浅野直喜, 小池智幸, 今谷晃, 正宗淳

日本消化器病学会雑誌(Web)　118　2021

ISSN： 1349-7693
新規内視鏡シミュレーターを用いた,消化管止血術学習プログラムによる教育介入研究

畑山裕, 菅野武, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

日本消化器病学会雑誌(Web)　118　2021

ISSN： 1349-7693
40年に及ぶ疫学的評価による本邦における食道胃接合部腺癌,食道腺癌の増加

畑山裕, 菅野武, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 金村政輝, 正宗淳

日本消化器病学会雑誌(Web)　118　2021

ISSN： 1349-7693
Helicobacter pylori感染による分化制御遺伝子Notch1の発現抑制を介した胃粘膜萎縮機序の解明

金笑奕, 浅野直喜, 今谷晃, 齋藤方志, 竹内章夫, 斉藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

日本消化器病学会雑誌(Web)　118　2021

ISSN： 1349-7693
Scoring systems for the prediction of choledocholithiasis: systematic review and meta-analysis (protocol) v1

Jun Watanabe, Takanori Sano, Takeshi Kanno, Kotani Kazuhiko, Atsushi masamune, Yuki Kataoka

2020/10/09
Publisher: {ZappyLab}, Inc.
DOI： 10.17504/protocols.io.bm7rk9m6 　
Scoring systems for the prediction of choledocholithiasis: systematic review and meta-analysis (protocol) v2

Jun Watanabe, Takanori Sano, Takeshi Kanno, Kotani Kazuhiko, Atsushi Masamune, Yuki Kataoka

2020/10/09
Publisher: {ZappyLab}, Inc.
DOI： 10.17504/protocols.io.bm7xk9pn 　
食道扁平上皮癌における分化制御遺伝子Sox2の発現増強による発癌・血管新生機序の解明

高橋貴一, 浅野直喜, 今谷晃, 金笑奕, 竹内章夫, 齋藤方志, 齊藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

日本消化器病学会雑誌　117　(臨増大会)　A692-A692　2020/10
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
食道扁平上皮癌における分化制御遺伝子Sox2の発現増強による発癌・血管新生機序の解明

高橋貴一, 浅野直喜, 今谷晃, 金笑奕, 竹内章夫, 齋藤方志, 齊藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

日本消化器病学会雑誌　117　(臨増大会)　A692-A692　2020/10
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
"安心して学び失敗できる"消化管出血に対する内視鏡的止血術習得に向けたシミュレーション教育の開発

菅野武, 荒田悠太郎, 加賀谷豊, 石井正, 小池智幸, 正宗淳

医学教育　51　(Suppl.)　111-111　2020/07
Publisher: (一社)日本医学教育学会
ISSN： 0386-9644
食道扁平上皮癌における分化制御遺伝子Sox2の発現増強による発癌・血管新生機序の解明

高橋貴一, 浅野直喜, 今谷晃, 金笑奕, 竹内章夫, 齋藤方志, 齊藤真弘, 中川健一郎, 菅野武, 八田和久, 宇野要, 小池智幸, 正宗淳

日本消化器病学会雑誌(Web)　117　2020

ISSN： 1349-7693
食道限局性アミロイドーシスの一例

藤谷拓, 八田和久, 小池智幸, 齊藤真弘, 中川健一郎, 菅野武, 金笑奕, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　208回　146-146　2020/01
Publisher: 日本消化器病学会-東北支部
壁細胞機能不全に伴う胃の多発NETの1例

阿部泰明, 八田和久, 小池智幸, 齊藤真弘, 金笑奕, 中川健一郎, 菅野武, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 阿曽沼祥, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　208回　153-153　2020/01
Publisher: 日本消化器病学会-東北支部
胃食道逆流症の病態と治療戦略 PPI抵抗性NERD患者における逆流時食道内pHと到達部位の検討

阿部泰明, 小池智幸, 菊池弘樹, 大方智樹, 乗田一明, 菅野武, 八田和久, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 下瀬川徹

日本消化管学会雑誌　2　(Suppl.)　96-96　2018/02
Publisher: (一社)日本消化管学会
ISSN： 2433-3840
東北大学病院総合診療外来における簡易心理検査の有用性と関連要因の検討 Peer-reviewed

野崎裕之, 中川高, 阿部倫明, 八木橋真央, 甲賀ひとみ, 吉村直仁, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菅野武, 鈴木聡子, 大澤稔, 菊池章子, 黒田仁, 高山真, 奈良正之, 富田博秋, 石井正

総合病院精神医学　29　(Suppl.)　S-203　2017/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
東日本大震災の被災地における医療体験実習は医学生の学習態度や進路に影響を与えるか?

田畑雅央, 荒田悠太郎, 菅野武, 井本博文, 石井正, 加賀谷豊

医学教育　48　(Suppl.)　123-123　2017/08
Publisher: (一社)日本医学教育学会
ISSN： 0386-9644
十二指腸非乳頭部NETの内視鏡的特徴多施設共同研究における胃NETとの比較より

八田和久, 小池智幸, 淺沼清孝, 菅野武, 荒誠之, 浅野直喜, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　59　(Suppl.1)　963-963　2017/04
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
早期胃癌ESD後除菌患者における異時性胃癌発生喫煙を中心とした生活因子との関連性

八田和久, 阿見麗子, 飯島克則, 小池智幸, 菅野武, 荒誠之, 淺沼清孝, 浅野直喜, 今谷晃, 下瀬川徹

胃病態機能研究会誌　49　18-18　2017/02
Publisher: (株)勁草書房コミュニケーション事業部
ISSN： 1880-3652
東北大学病院総合診療外来新患におけるうつ度および認知度の実態調査

阿部倫明, 野崎裕之, 中川高, 八木橋真央, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菅野武, 宇佐美修, 大澤稔, 黒田仁, 高山真, 奈良正之, 富田博秋, 石井正

日本プライマリ・ケア連合学会学術大会抄録集　8th　2017
当院における表在型Barrett食道癌の内視鏡治療成績

菊池弘樹, 小池智幸, 齊藤真弘, 菅野武, 八田和久, 荒誠之, 淺沼清孝, 浅野直喜, 今谷晃, 下瀬川徹

日本消化管学会総会学術集会プログラム・抄録集　13th　173　2017

ISSN： 2189-9037
Typical Features of Peptic Ulcers after the Great East Japan Earthquake and Tsunami

菅野武, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

心身医学　57　(10)　999-1004　2017
Publisher: 一般社団法人日本心身医学会
DOI： 10.15064/jjpm.57.10_999 　

ISSN： 0385-0307
The analysis for use of percutaneous endoscopic gastrostomy placed prophylactically for head and neck cancer treated with chemoradiotherapy

Nobuyuki Ara, Takeshi Kanno, Waku Hatta, Kiyotaka Asanuma, Naoki Asano, Tomoyuki Koike, Akira Imatani, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　31　351-352　2016/11

ISSN： 0815-9319

eISSN： 1440-1746
Factors associated with the development of secondary esophageal squamous cell carcinomas after endoscopic resection for superficial esophageal squamous cell carcinomas

Waku Hatta, Kazuaki Norita, Tomoyuki Koike, Takeshi Kanno, Nobuyuki Ara, Kiyotaka Asanuma, Naoki Asano, Akira Imatani, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　31　12-12　2016/11

ISSN： 0815-9319

eISSN： 1440-1746
Vonoprazan reduces the GERD symptoms in the symptom index positive PPI-refractory NERD

Tomoyuki Koike, Msahiro Saito, Hiroki Kikuchi, Kazuaki Norita, Takeshi Kanno, Waku Hatta, Nobuyuki Ara, Kiyotaka Asanuma, Naoki Asano, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　31　21-21　2016/11

ISSN： 0815-9319

eISSN： 1440-1746
大災害ストレスの心身医学災害時急性期ストレスと上部消化管東日本大震災後の消化性潰瘍の増加とその特徴

菅野武, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

心身医学　56　(6)　591-591　2016/06
Publisher: (一社)日本心身医学会
ISSN： 0385-0307
消化管出血における診断と治療の現状と今後の展望上部消化管潰瘍出血に関わる因子の検討

菅野武, 小池智幸, 飯島克則

Gastroenterological Endoscopy　58　(Suppl.1)　552-552　2016/04
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
難治性嚥下障害を呈したリンパ球性食道炎の一例

前嶋隆平, 宇野要, 飯島克則, 藤島史喜, 野口哲也, 本田純也, 菅野武, 日下玄, 近藤穣, 八田和久, 荒誠之, 淺沼清孝, 浅野直喜, 小池智幸, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　58　(Suppl.1)　785-785　2016/04
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
Intense Gastro-Esophageal Reflux May Influence the Localization of Barrett's Adenocarcinoma: Measured by 24-h pH-Impedance Monitoring

Masahiro Saito, Tomoyuki Koike, Hiroki Kikuchi, Kazuaki Norita, Kenichirou Nakagawa, Takeshi Kanno, Gen Kusaka, Yutaka Kondo, Waku Hatta, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Katsunori Iijima, Tooru Shimosegawa

GASTROENTEROLOGY　150　(4)　S483-S483　2016/04

ISSN： 0016-5085

eISSN： 1528-0012
PPI抵抗性NERD患者における24hr MLL-pHモニタリングの基線値の検討

菊池弘樹, 小池智幸, 乗田一明, 齊藤真弘, 菅野武, 近藤穣, 日下玄, 八田和久, 荒誠之, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 下瀬川徹

日本消化器病学会雑誌　113　(臨増総会)　A229-A229　2016/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
[New trends of acid-related diseases treatment].

Koike, Tomoyuki, Nakagawa, Kenichiro, Kanno, Takeshi, Iijima, Katsunori, Shimosegawa, Tooru

Nihon Rinsho　73　(7)　1136-1146　2015
当院における頭頸部癌治療後消化管狭窄への内視鏡的バルーン拡張術の検討

前嶋隆平, 飯島克則, 本田純也, 白木健悠, 中川健一郎, 金笑奕, 菅野武, 新海洋彦, 伏谷淳, 近藤穣, 八田和久, 遠藤博之, 荒誠之, 宇野要, 浅野直喜, 小池智幸, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　56　(Suppl.1)　1070-1070　2014/04
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
特発性潰瘍の特徴

菅野武, 飯島克則, 小池智幸, 阿部靖彦, 大矢内幹, 伊藤博敬, 阿曽沼祥, 下瀬川徹

Gastroenterological Endoscopy　56　(Suppl.1)　1088-1088　2014/04
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
Helicobacter pylori除菌後胃癌発見のためのpit fall 2)胃酸分泌領域の変化からみたHelicobacter pylori除菌後胃癌の特徴

小池智幸, 飯島克則, 中川健一郎, 菅野武, 今谷晃, 関根仁, 大原秀一, 下瀬川徹

Helicobacter Res　18　(2)　102-108　2014/04/01
Publisher: (株)先端医学社
ISSN： 1342-4319
特発性潰瘍の頻度調査多施設共同・前向き研究

菅野武, 飯島克則, 小池智幸, 下瀬川徹, 阿部靖彦, 大矢内幹, 伊藤博敬, 阿曽沼祥

日本消化器病学会雑誌　110　(臨増大会)　A891-A891　2013/09
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
巻頭インタビュー菅野武医師に聞く「患者に寄り添う医療」とは (寄り添い力)

菅野武

医道の日本 = The Japanese journal of acupuncture & manual therapies　72　(5)　12-17　2013/05
Publisher: 医道の日本社
ISSN： 0287-6760
被災病院での体験とストレス : 津波を直接経験した医療者として

菅野武

日本心療内科学会誌　16　(4)　269-269　2012/11/20

ISSN： 1342-9558
[Experience and measures taken by Great East Japan earthquake and tsunami-stricken hospital (Shizugawa Public Hospital)].

Kanno T

Masui. The Japanese journal of anesthesiology　61　(増刊)　S41-S47　2012/11
Publisher: 克誠堂出版(株)
ISSN： 0021-4892
東日本大震災後の出血性潰瘍のリスクについての検討

菅野武, 阿部靖彦, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

日本消化器病学会雑誌　109　(臨増大会)　A786-A786　2012/09
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
食道表在癌(扁平上皮癌・腺癌)に対する内視鏡治療後の予後に関する検討

中川健一郎, 小池智幸, 宇野要, 白木健悠, 金笑奕, 菅野武, 荒誠之, 浅野直喜, 阿部靖彦, 飯島克則, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　54　(Suppl.2)　2840-2840　2012/09
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
食道胃接合部腺癌・噴門部癌に対する内視鏡治療後の予後に関する検討

中川健一郎, 小池智幸, 宇野要, 白木健悠, 金笑奕, 菅野武, 荒誠之, 浅野直喜, 阿部靖彦, 飯島克則, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　54　(Suppl.2)　2882-2882　2012/09
Publisher: (一社)日本消化器内視鏡学会
ISSN： 0387-1207

eISSN： 1884-5738
東日本大震災被災地域における消化性潰瘍症例の検討

菅野武, 阿部靖彦, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

日本消化器病学会雑誌　109　(臨増総会)　A274-A274　2012/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
志津川での日々は忘れない (TIME誌「世界の百人」に選ばれた被災地の英雄のそれから)

菅野武

文芸春秋　89　(11)　211-213　2011/09
Publisher: 文芸春秋
新しい命がくれた覚悟 (大震災・医師たちの闘い)

菅野武, 増田晶文

新潮45　30　(8)　122-128　2011/08
Publisher: 新潮社

Show all ︎Show first 5

Books and Other Publications 13

消化器疾患最新の治療 2025-2026 （編集: 山本博徳, 瀬戸泰之,吉治仁志）

菅野武, 小池智幸

南江堂　2025/04

ISBN: 9784524211425
Web版「家庭の医学」https://medical.jiji.com/medical/（「時事メディカル」サイト内）

菅野武

時事通信社　2024/12
患者さんとご家族のための消化性潰瘍ガイド2023

消化性潰瘍診療ガイドライン委員会

日本消化器病学会　2023/10
みんなで取り組む災害時の保健・医療・福祉活動（編集: 國井修; 尾島俊之）

菅野武, 石井正

南山堂　2022/02

ISBN: 9784525184810
消化性潰瘍診療ガイドライン2020 改訂第3版

日本消化器病学会

南江堂　2020/06

ISBN: 9784524225446
消化器疾患最新の治療 2019-2020（編集: 小池和彦;山本博徳;瀬戸泰之）

菅野武, 小池智幸

南江堂　2019/03

ISBN: 9784524245499
病院からの全患者避難～災害医療フォーラム全講演

福田幾夫, 菅野武ほか

2017/09

ISBN: 9784753228515
消化器画像診断アトラス（編集: 下瀬川徹;小池智幸;遠藤克哉;井上淳;正宗淳）

菅野武

中山書店　2017/08

ISBN: 9784521745442
「生と死」の21世紀宣言Part6 (苦しみの意味と再生への道)

菅野武, 池澤夏樹, 柳田邦男, 井上ウィマラ, 井村裕夫, 森崎雅好

青海社.　2014/09

ISBN: 9784902249729
今を生きる-東日本大震災から明日へ！復興と再生への提言-4.医療と福祉（編集: 久道茂;鴨池治）

菅野武

東北大学出版会　2013/02

ISBN: 9784861632068
循環器内科医のための災害時医療ハンドブック（日本心臓病学会）

菅野武

日本医事新報社　2012/09

ISBN: 9784784954605
いのちを守る－東日本大震災・南三陸町における医療の記録

佐藤仁, 菅野武, 西澤匡史, 杉本勝彦, 鵜飼卓, 奥村順子, ほ

へるす出版　2012/02

ISBN: 9784892697630
寄り添い支える―公立志津川病院若き内科医の3・11

菅野武

河北新報社　2011/12

ISBN: 4873412676

Show all Show first 5

Presentations 219

Impacts of H. pylori Infection and Acid Suppression on the Duodenal Microbiome

2025/07/11
当院での胃内視鏡廃液を使用したH. pylori核酸増幅法の使用経験

畑山裕, 菅野武, 小池智幸, 尾形洋平, 齊藤真弘, 金笑奕, 八田和久, 宇野要, 今谷晃, 正宗淳

第31回日本ヘリコバクター学会学術集会　2025/07/11
ハイリスクな内視鏡治療を Simulator-based trainingで安全に学べる時代へ：小児内視鏡教育リカレント教育への可能性 Invited

菅野武

第52回日本小児内視鏡研究会教育講演　2025/07/06
出血し治療手技ができる消化器内視鏡シミュレータの開発と教育 Invited

菅野武

第48回日本バイオレオロジー学会リサーチ・フォーラム（特別講演）　2025/06/29
育休ブログを用いたテキストマインニングによる探索的研究～義務年限内で取得した男性育休の経験から～

滝井孝英, 才津旭弘, 菅野武

第18回へき地・地域医療学会　2025/06/29
百聞一見～地域の先輩を訪ねて～被災地でのインタビューから学ぶ地域医療

住茜音, 才津旭弘, 菅野武

第18回へき地・地域医療学会　2025/06/28
百聞一見～地域の先輩を訪ねて～女川町出島での住民座談会に参加して

吉川紫, 才津旭弘, 菅野武

第18回へき地・地域医療学会　2025/06/28
百聞一見～地域の先輩を訪ねて～女川町の災害復興から学ぶ住民主体のまちづくり

遠藤優希, 才津旭弘, 菅野武

第18回へき地・地域医療学会　2025/06/28
医学生による「さんぽ連句会」ワークショップの活動報告

平こころ, 才津旭弘, 菅野武

第18回へき地・地域医療学会　2025/06/28
男性医師による育休ブログのテキスト解析からみえた可能性と限界

滝井孝英, 才津旭弘, 菅野武

第16回日本プライマリ・ケア連合学会学術大会　2025/06/22
医学生による災害復興を通して学ぶ地域医療

住茜音, 菅野武, 才津旭弘, 滝井孝英, 遠藤優希, 吉川紫

第16回日本プライマリ・ケア連合学会学術大会　2025/06/22
医学生による女川町災害復興の学び：住民主体のまちづくりへの取り組み

遠藤優希, 菅野武, 才津旭弘, 滝井孝英, 吉川紫, 住茜音

第16回日本プライマリ・ケア連合学会学術大会　2025/06/22
宮城県女川町出島での住民座談会にファシリテーターとして参加して

吉川紫, 菅野武, 才津旭弘, 滝井孝英, 住茜音, 遠藤優希

第16回日本プライマリ・ケア連合学会学術大会　2025/06/22
胃ESD 中の出血管理におけるGel immersion endoscopy の課題と展望

林宏樹, 赤星和明, 大和田潤, 上野貴, 野本佳恵, 福田久, 高橋治夫, 井野裕治, 菅野武, 矢野智則, 山本博徳

第109回日本消化器内視鏡学会総会附置研究会（第 1 回内視鏡用視野確保ゲルを用いた内視鏡診断および治療手技に関する研究会）　2025/05/11
急性出血性直腸潰瘍の前向きコホート研究：止血時にゲルを用いる有用性を含めた検討

菅野武, 滝井孝英, 才津旭弘, 角田洋一, 関口裕美, 竹澤敬人, 正宗淳, 矢野智則

第 109 回日本消化器内視鏡学会総会附置研究会（第 1 回内視鏡用視野確保ゲルを用いた内視鏡診断および治療手技に関する研究会）　2025/05/11
ピュアスタット®︎とGel Immersion Endoscopy導入前後の十二指腸球後部潰瘍に対する治療成績の比較

関口裕美, 菅野武, 竹澤敬人, 井野裕治, 福田久, 髙橋治夫, 野本佳恵, 上野貴, 林宏樹, 赤星和明, 大澤博之, 山本博徳

第109回日本消化器内視鏡学会総会　2025/05/09
東日本大震災の被災と継承:全病院避難と受援の経験を、人材育成へどうつなげるか Invited

菅野武

第41回臨床研修研究会シンポジウム２初期研修と災害活動　2025/04/19
Computer-aided diagnosis for colorectal polyp in comparison with endoscopists: A systematic review and meta-analysis International-presentation

Satoshi Shinozaki, Jun Watanabe, Takeshi Kanno, Yuhong Yuan, Tomonori Yano, Hironori Yamamoto

ESGE(European Society of Gastrointestinal Endoscopy) Days 2025　2025/04/03
地域医療と災害:被災した医療者としてレジリエンスを考える Invited

菅野武

令和6年度広島県医師会勤務医部会総会特別講演　2025/03/29
東日本大震災における被災の実際と課題の継承:被災した医療者として Invited

菅野武

第158回埼玉小児疾患集談会特別講演　2025/03/13
新規ERCP/ESTドライシミュレータモデルの開発と教育介入研究

畑山裕, 菅野武, 滝川哲也, 佐野貴紀, 松本諒太郎, 田中裕, 齊藤真弘, 金笑奕, 三浦晋, 八田和久, 濱田晋, 宇野要, 菊田和宏, 今谷晃, 小池智幸, 正宗淳

第21回日本消化管学会総会学術集会ワークショップ2　2025/02/21
今を生き、明日へとつなごう：自己実現と忘己利他のあいだで Invited

菅野武

第41回九州地域医学研究会特別講演　2025/02/15
胃穿破を来した膵臓・胃動静脈奇形に対し，内視鏡的止血後に根治的外科切除術を施行した1 例

尾形洋平, 畑山裕, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 宇野要, 小池智幸, 今谷晃, 前田晋平, 水間正道, 海野倫明, 正宗淳

日本消化器病学会東北支部第218回例会　2025/02/08
Barrett 食道腺癌における食道運動機能の検討

谷地一真, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 首藤千博, 畑山裕, 尾形洋平, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会東北支部第218回例会　2025/02/08
PPI 抵抗性NERD 患者におけるexcessive supragastric belching と食道内逆流の関連についての検討

首藤千博, 齊藤真弘, 小池智幸, 小泉薫, 皆瀬ゆみ子, 谷地一真, 畑山裕, 尾形洋平, 金笑奕, 菅野武, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会東北支部第218回例会　2025/02/08
細径処置スコープEG-840TP を用いた，咽喉頭癌・食道癌治療後狭窄を有する症例における上部消化管ESD の検討

尾形洋平, 八田和久, 小池智幸, 畑山裕, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 今谷晃, 正宗淳

日本消化器病学会東北支部第218回例会シンポジウム　2025/02/08
Simulation-based trainingで消化器内視鏡治療を安全に学べる時代へ：リカレント教育（学び直し）, 若手教育への期待

菅野武

日本消化器病学会東北支部第218回例会シンポジウム基調講演　2025/02/08
生体肝移植術後空腸静脈瘤出血に対し内視鏡的静脈瘤硬化療法を行った１例

梶浦大貴, 宇野要, 粂潔, 畑山裕, 齊藤真弘, 小池智幸, 尾形洋平, 金笑奕, 菅野武, 八田和久, 下山雄丞, 志賀永嗣, 二宮匡史, 今谷晃, 正宗淳

第173回日本消化器内視鏡学会東北支部例会　2025/02/07
多発性内分泌腫瘍症1 型を併存する多発十二指腸非機能性NET の一例

加宅田公子, 八田和久, 畑山裕, 尾形洋平, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 小池智幸, 今谷晃, 正宗淳

第173回日本消化器内視鏡学会東北支部例会　2025/02/07
臨床経験とリンクする、実践的なERCP/EST シミュレータ学習コンテンツの検討

畑山裕, 菅野武, 滝川哲也, 小池智幸, 正宗淳

第173 回日本消化器内視鏡学会東北支部例会特別シンポジウム　2025/02/07
上部消化管障害の治療と治療内視鏡のシミュレータ開発について

菅野武

柴田郡医師会学術講演会講演　2024/12/16
東日本大震災の被災と継承：全病院避難と受援の経験から、人材育成へ

菅野武

第13回日本プライマリ・ケア連合学会関東甲信越ブロック地方会シンポジウム２　2024/12/01
義務内に被災した医療者が、今は学生教育・災害支援に：はじめから強かったわけではないんです Invited

菅野武

令和6年度岐阜県地域医療研究会特別講演　2024/11/30
Prevalence and Endoscopic Characteristics of Dyspepsia in Japanese Adults: Insights from a Cancer Screening Initiative International-presentation

Suguo Suzuki, Takeshi Kanno, Tomoyuki Koike, Takashi Chiba, Kiyotaka Asanuma, Katsuaki Kato, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Akira Imatani, Atsushi Masamune

Asian Pacific Digestive Week 2024　2024/11/23
支援を受け止める「受援」とレジリエンス～被災した医療者として～ Invited

菅野武

令和6年度東京臨海病院地域医療連携情報交換会講演　2024/11/22
津波災害とレジリエンス：被災した医療者として次に残すこと

菅野武

長崎大学・福島県立医科大学共同大学院修士課程災害・被ばく医療科学専攻「地域医療学」特別講義　2024/11/06
バトンをつなぐ～被災と喪失の先に何を残すか～

菅野武

令和6年度自治医科大学熊本県人会総会特別講演　2024/11/02
侵襲的内視鏡治療の安全な学習方法の確立潰瘍止血とERCP/ESTシミュレータ開発を通して

菅野武

第170回備後内視鏡研究会特別講演　2024/08/07
ERCP/ESTシミュレータ学習はリスク低減に寄与できるか：新規モデル開発と教育介入研究

畑山裕, 菅野武, 滝川哲也, 池田未緒, 佐野貴紀, 松本諒太郎, 三浦晋, 濱田晋, 粂潔, 菊田和宏, 正宗淳

第55回日本膵臓学会大会ワークショップ6　2024/07/26
薬剤起因性を含む上部消化管障害の治療と止血術シミュレータ開発

菅野武

Shirakawa GI Forum 講演　2024/07/11
臨床実習前の医学生の地域医療実習の意義：三施設を見学した得た学びから

平こころ, 才津, 旭弘, 菅野武

第１７回へき地地域医療学会　2024/06/29
自治医科大学同窓会支援プロジェクトのコンセプトと概要：医療の谷間はそこにある Invited

菅野武

第１７回へき地地域医療学会　2024/06/29
Prevalence of Dyspepsia by H. pylori Infection Status : An Epidemiological Analysis Based on Data from an Adult Gastric Cancer Screening Program

Takeshi Kanno, Suguo Suzuki, Tomoyuki Koike, Takashi Chiba, Kiyotaka Asanuma, Katsuaki Kato, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Xiaoyi Ji, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Atsushi Masamune

2024/06/21
上部消化管障害の治療と止血術シミュレータ開発 Invited

菅野武

角田医師会学術講演会講演　2024/06/20
侵襲的内視鏡手技に対する教育と評価：新規シミュレータ開発を通して明確となった課題

2024/06/01
一般成人におけるディスペプシアの疫学と内視鏡所見：がん検診事業のデータから

鈴木直生, 菅野武, 小池智幸, 千葉隆士, 淺沼清孝, 加藤勝章, 尾形洋平, 齊藤真弘, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

第110回日本消化器病学会総会　2024/05/11
From Victim to Visionary: My Role as a Medical Professional through Disaster and Recovery International-presentation Invited

2024/03/09
The involvement of pharmacists contributed efficient medicine distribution to the affected people in Ishinomaki area after the 2011 Great East Japan Earthquake

2024/02/23
ストレスと胃十二指腸潰瘍：東日本大震災と１０年後のＱＯＬを加味した検討

菅野武, 只野恭教, 前嶋隆平, 赤羽武弘, 小池智幸, 石井正

第51回日本潰瘍学会シンポジウム2 ストレス潰瘍2024　2024/02/11
消化管出血（上部）

菅野武

第21回日本消化管学会教育講演会消化管診療の基本と最新情報　2024/02/11
内視鏡的粘膜下層剥離術を施行した粘膜内限局リンパ球浸潤胃癌の一例

丹野尚太郎, 尾形洋平, 八田和久, 小池智幸, 齊藤真弘, 金, 笑, 菅野武, 宇野要, 浅野直喜, 今谷晃, 正宗淳, 山崎有人, 藤島史喜

第171回日本消化器内視鏡学会東北支部例会　2024/02/02
ボノプラザン投与により軽快した Hypercontractile esophagus の一例

小泉薫, 齊藤真弘, 小池智幸, 谷地一真, 首藤千博, 皆瀬ゆみ子, 尾形洋平, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

第171回日本消化器内視鏡学会東北支部例会　2024/02/02
講演東日本大震災における実際とレジリエンス：被災した医療者として Invited

菅野武

新潟日報・河北新報防災むすび塾「東日本大大震災を忘れない―被災体験を聞く会」　2023/12/16
災害医療と地域医療：過去に学び明日へとつなぐ Invited

菅野武

第36回静岡県地域医学研究会特別講演１　2023/11/19
東日本大震災における被災の実際と課題の継承：被災した医療者として Invited

菅野武

第36回日本総合病院精神医学会総会シンポジウム22　2023/11/18
津波災害とレジリエンス：被災した医療者の12年

菅野武

長崎大学・福島県立医科大学共同大学院修士課程災害・被ばく医療科学専攻「地域医療学」特別講義　2023/11/08
シミュレータ学習プログラムは安全なESTの達成および自覚的習熟度の向上に寄与する:前向き教育介入研究

畑山裕, 菅野武, 滝川哲也, 齊藤真弘, 金笑奕, 三浦晋, 八田和久, 濱田晋, 宇野要, 粂潔, 菊田和宏, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

第31回日本消化器関連学会週間 JDDW2023　2023/11/04
地域医療と災害医療：被災した医療者としての10年、レジリエンス Invited

菅野武

第50回日本小児栄養消化器肝臓学会学術集会特別講演3　2023/10/22
THE EDUCATIONAL PROGRAM WITH A NOVEL EST SIMULATOR CAN CONTRIBUTE TO ACHIEVE SAFE EST AND TO IMPROVE TRAINEE’S CONFIDENCE OF THE EST PROCEDURE: AN EDUCATIONAL INTERVENTION STUDY International-presentation

United European Gastroenterology (UEG) Week 2023　2023/10/15
特別講演内視鏡的止血術シミュレータの開発：地域医療の課題を社会の財産に変える Invited

菅野武

第17回宮城プライマリ・ケア研究会　2023/07/08
地域でつながりかがやく医療人になろう：世界の100人に選ばれて12年これまでとこれから Invited

菅野武

山口県立総合医療センター臨床研修研修会、第70回鬼怒川勉強会特別講演会　2023/07/08
ステロイド嚥下療法により食道運動機能障害の改善を認めた好酸球性食道炎の一例

谷地一真, 齊藤真弘, 小池智幸, 首藤千博, 尾形洋平, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

日本消化器病学会東北支部第215回例会　2023/07/07
肝様腺癌を伴った胃腺癌（Adenocarcinoma with focal hepatoid adenocarcinoma）の一例

加宅田公子, 菅野武, 宇野要, 尾形洋平, 齊藤真弘, 金笑奕, 八田和久, 浅野直喜, 今谷晃, 小池智幸, 正宗淳, 藤島史喜

日本消化器病学会東北支部第215回例会　2023/07/07
検診で発見されたBarrett食道腺癌の臨床病理学的特徴

谷地一真, 齊藤真弘, 小池智幸, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 正宗淳

第62回日本消化器がん検診学会総会　2023/07/01
検診にて発見された非機能性十二指腸NETに対してEMROにて断端陰性切除となった一例

鈴木直生, 八田和久, 小池智幸, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 浅野直喜, 今谷晃, 正宗淳

第62回日本消化器がん検診学会総会　2023/07/01
胃がん2次検診で胃粘膜下腫瘍が疑われ、難治性特発性胃潰瘍であった一例

川邉誠, 菅野武, 小野義高, 宇野, 要, 小池智幸

第62回日本消化器がん検診学会総会　2023/07/01
プロフェッショナルとしての自分を育てる～つなげる、つながること～ Invited

菅野武

第16回へき地・地域医療学会メインシンポジウム「地域医療の過去と未来～さあ行こう、新しい景色へ～」　2023/06/25
COVID-19軽症者等療養施設におけるモルヌピラビルの効果と安全性

有田龍太郎, 高山真, 阿部倫明, 菊地章子, 大澤稔, 小野寺浩, 菅野武, 齊藤奈津美, 赤石哲也, 小野理恵, 只野恭教, 鈴木聡子, 菅原章人, 石井正

日本プライマリ・ケア連合学会学術大会　2023/05
腹部症状と内視鏡所見の乖離：無症候性好酸球浸潤例を含む9例の胃・十二指腸好酸球浸潤症例の検討

菅原英之, 菅野武, 正宗淳

第109回日本消化器病学会総会シンポジウム10 好酸球性消化管疾患の診断と治療　2023/04/08
大規模災害後増加する消化性潰瘍：その治療戦略

菅野武

Nexium×Ondexxya TV Symposium 2023 南海トラフ巨大地震に備えて～医療者である我々にできること～　2023/03/15
Facts and issues of online practice in human resource education of disaster medicine

2023/03/10
Risk factors of developing severe disease and prolonged care period in COVID-19 patients who stayed at a recovery accommodation facility

2023/03/10
医師である私たちのできること‐東日本大震災の経験を通して‐ Invited

菅野武

黒潮医療人養成プロジェクト第1回合同シンポジウム特別講演　2023/03/01
侵襲的内視鏡手技の、患者にも学習者にも、安心な学習方法を目指して合併症の再現できるシミュレータ ”Medical Rising STAR” の開発

菅野武

第169回消化器内視鏡学会東北支部例会教育セミナー　2023/02/10
非H. pylori 非NSAIDs潰瘍の診療：鑑別診断と特発性潰瘍 Invited

菅野武, 小池智幸, 正宗淳

第19回日本消化管学会総会学術集会パネルディスカッション２―非HP非NSAID・難治性胃・十二指腸潰瘍の診断と治療　2023/02/03
新規消化管潰瘍止血モデル（Rising STAR-U）を用いた，初期研修医への教育介入研究

畑山裕, 菅野武, 鈴木直生, 荒田悠太郎, 小池智幸, 正宗淳

第20回東北シミュレーション医学医療教育研究会大会　2022/11/26
論文の種類の違い Systematic reviewの読み方

菅野武

ゼリア新薬社外講師勉強会　2022/11/25
消化器内視鏡領域における合併症の再現できる手技シミュレータの開発 Invited

菅野武

医療用立体モデルコンソーシアム会員限定講演会　2022/11/01
(IS-S4-1_E) Novel Simulator for Endoscopic Hemostasis Provides Opportunity to Foster Confidence and Interest in Endoscopic Therapy for Diverse Learners

Takeshi Kanno, Tomoyuki Koike, Atsushi Masamune

第30回日本消化器関連学会週間JDDW 2022　2022/10/29
出血を再現した十二指腸ESTシミュレータモデルの開発

畑山裕, 菅野武, 滝川哲也, 齊藤真弘, 金笑奕, 三浦晋, 八田和久, 濱田晋, 宇野要, 粂潔, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

第30回日本消化器関連学会週間JDDW 2022　2022/10/29
ランチョンセミナー56(消化器内視鏡学会) 南海トラフ巨大地震に備えて～医療者である我々にできること～【共催：アストラゼネカ(株)】大規模災害後増加する消化性潰瘍：その治療戦略 Invited

菅野武

第30回日本消化器関連学会週間JDDW 2022　2022/10/28
上部消化管出血患者における, ボノプラザンのPPI内服に対する再出血・死亡リスクの検討－傾向スコアを用いたDPCデータベース解析－

阿部寛子, 八田和久, たら澤邦男, 小野義高, 尾形洋平, 齊藤真弘, 菅野武, 金笑奕, 宇野要, 小池智幸, 今谷晃, 藤森研司, 伏見清秀, 正宗淳

第30回日本消化器関連学会週間JDDW 2022　2022/10/27
胃・十二指腸に好酸球浸潤を伴う症例の特徴

菅原英之, 菅野武, 齊藤真弘, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

第227回日本内科学会東北地方会　2022/09/03
LSBE内に発生し、癌との鑑別が困難であった隆起性炎症性ポリープの一例

谷地一真, 齊藤真弘, 小池智幸, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 藤島史喜, 正宗淳

第168回日本消化器内視鏡学会東北支部例会　2022/07/02
内視鏡治療後経過観察中に診断・治療し得た早期食道神経内分泌癌の一例

田邊瑞樹, 齊藤真弘, 宇野要, 金笑奕, 菅野武, 八田和久, 浅野直喜, 小池智幸, 今谷晃, 藤島史喜, 佐藤千晃, 谷山裕亮, 亀井尚, 正宗淳

第168回日本消化器内視鏡学会東北支部例会　2022/07/02
東日本大震災を通して地域医療の力を考える Invited

菅野武

自治医科大学医学部6年災害医療講義　2022/06/10
消化性潰瘍診療Update 災害時潰瘍から最新の知見まで

菅野武

上部消化管疾患治療セミナー　2022/06/08
過去に学び今を生き明日に備える～大規模災害からのレジリエンス～

菅野武

３１１『伝える／備える』次世代塾　2022/05/21
Session 1. 日常診療で悩ましい上部消化管疾患の話題

菅野武

Reiwa GI meetig　2022/05/16
Education with a novel simulator for endoscopic hemostasis contributes to improving pediatric endoscopists’ skill and motivation

2022/05/15
SIMULATOR-BASED LEARNING OF ENDOSCOPIC HEMOSTASIS WITH A NOVEL MODEL STAR-U FOR BEGINNER TRAINEES: AN EDUCATIONAL INTERVENTION STUDY

T. Kanno, Y. Arata, Y. Hatayama, M. Saito, X. Jin, W. Hatta, K. Uno, N. Asano, A. Imatani, T. Koike, A. Masamune

ENDO 2022 - 3rd World Congress of GI Endoscopy　2022/05/13
Diagnostic and medical treatment approaches for idiopathic PUD Invited

Takeshi Kanno, Tomoyuki Koike, Atsushi Masamune

The 30th Annual Meeting of the Korean College of Helicobacter. The 4th International Symposium on Helicobacter and Upper Gastrointestinal Disease (HUG 2022) Scientific Session 5: PUD: Diagnosis, Prevention, Complications, and More.　2022/03/19
注目すべき非 H. pylori・非 NSAIDs 潰瘍：特発性潰瘍の現状と課題

菅野武, 小池智幸, 正宗淳

第18回日本消化管学会総会学術集会パネルディスカッション２―治療適応；内科・外科の立場から―難治性胃十二指腸潰瘍　2022/02/11
消化性潰瘍診療のコツ～生検・診断など基本からガイドライン2020の最新知見まで～

菅野武

第8回岩手県南消化器 Meeting　2022/01/20
東日本大震災の経験をもとに災害医療や防災教育を考える～被災した医療者としての10 年の足跡～

菅野武

宮城県高等学校教頭副校長会本吉地区会教育講演　2021/12/03
40年に及ぶ疫学的評価による本邦における食道胃接合部腺癌，食道腺癌の増加

畑山裕, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 金村政輝, 正宗淳

第29回日本消化器関連学会週間 JDDW2021　2021/11/05
東日本大震災に被災した医療者としての10 年の足跡～困難と向き合うということ～

菅野武

第23回日本病院総合診療医学会学術総会会長招聘講演２　2021/09/19
地域一次医療機関でかかりつけ医が積極的に大腸がん検診の受診歴を確認し介入する意義

菅谷涼, 菅野武, 安藤舜典, 八坂寛久, 枡みすず, 大友正隆

第23回日本病院総合診療医学会学術総会　2021/09/18
SS02-2 内視鏡的止血術に対する、新規ドライシミュレータを用いたオンラインハンズオンスキルセミナーへの挑戦

菅野武, 畑山, 裕荒田, 悠太郎, 小池, 智幸, 正宗, 淳石井正

第53回日本医学教育学会大会　2021/07/31
内反性発育(inverted growth)を呈した早期胃癌の1例

畑山裕, 菅野武, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 藤島史喜, 正宗淳

第223回日本内科学会東北地方会　2021/06/19
東日本大震災を通して地域医療の力を考える Invited

菅野武

自治医科大学医学部6年災害医療講義　2021/06/11
医療者にできること～東日本大震災の経験を経て～ Invited

菅野武

高知大学医学部4年災害・救急医療学講義　2021/06/09
Interactive Training With A Novel Simulation Model For Upper Gastrointestinal Endoscopic Hemostasis Improves Trainee’s Technique And Confidence: Educational Intervention Study International-presentation

Takeshi Kanno, Yutaro Arata, Eric Greenwald, Paul Moayyedi, Yutaka Hatayama, Masahiro Saito, Kenichiro Nakagawa, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Yutaka Kagaya, Tadashi Ishii, Tomoyuki Koike, Atsushi Masamune

Digestive Disease Week 2021　2021/05/23
精神科の現場で知っていてほしい「腹痛」への一次対応 Invited

菅野武

第5回東北CNS倶楽部教育講演　2021/05/21
過去に学び今を生き明日に備える～大規模災害からのレジリエンス～ Invited

菅野武

３１１『伝える／備える』次世代塾　2021/05/15
新規内視鏡シミュレータを用いた, 消化管止血術学習プログラムによる教育介入研究

畑山裕, 菅野武, 齊藤真弘, 中川健一郎, 金笑奕, 八田和久, 宇野要, 浅野直喜, 今谷晃, 小池智幸, 正宗淳

第107回日本消化器病学会総会　2021/04/15
災害時における抗凝固薬の適切な使用への提案～災害時潰瘍出血のリスク因子解析から～ Invited

菅野武, 只野恭教, 石井正

第26回日本災害医学会総会・学術集会パネルディスカッション19「災害時における深部静脈血栓・肺血栓塞栓症の治療方略」　2021/03/17
与えられた「いのち」をどう生きますか？～東日本大震災を経験した医師として～

菅野武

唐丹中学校いのちの教育講演会　2021/02/22
消化性潰瘍診療ガイドライン2020にみるH. pylori 陰性時代の潰瘍マネジメント

菅野武

Collaboration Seminar between Cardiology and Gastroenterology　2021/02/10
消化性潰瘍診療ガイドライン2020

菅野武

Tohoku Takecab GI channel　2020/10/12
消化性潰瘍診療に関する最新の知見～ガイドライン2020の話題を踏まえて～ Invited

菅野武

Nexium Web Seminar in Miyagi　2020/09/29
A NOVEL SIMULATION MODEL FOR UPPER GASTROINTESTINAL HEMOSTASIS

2020/07/17
東日本大震災を通して地域医療の力を考える Invited

自治医科大学医学部6年災害医療講義　2020/06/12
医療者にできること～東日本大震災の経験を経て～ Invited

高知大学医学部4年災害・救急医療学講義　2020/06/10
Su1394 SELECTION OF CLARITHROMYCIN IN FIRST-LINE HELICOBACTER PYLORI TRIPLE ERADICATION THERAPY BASED ON PREVALENCE OF RESISTANCE TO ANTIMICROBIAL AGENTS: AN UPDATED META ANALYSIS.

Masaki Murata, Mitsushige Sugimoto, Hitomi Mizuno, Takeshi Kanno, Kiichi Satoh

Digestive Disease Week 2020　2020/05
PREVALENCE AND RISK FACTORS FOR LYMPH NODE METASTASIS AFTER NONCURATIVE ENDOSCOPIC RESECTION FOR EARLY GASTRIC CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS

2020/05
過去に学び今を生き明日へとつなぐ：東日本大震災の被災の実際と課題 Invited

菅野武

第6回日本医療安全学会学術集会総会（感染対策でWeb開催に変更）　2020/03/27
医療者にできること：東日本大震災の被災の実際と課題 Invited

菅野武

宮崎県立延岡病院延岡市医師会災害医療講演会　2020/02/17
災害医療と地域医療～初めから特別な人なんていない～ Invited

菅野武

東北医科薬科大学令和元年度医学生交流支援事業　2020/02/06
Experience and Resilience from Great East Japan earthquake and Tsunami Invited

Takeshi Kanno

Niigata/Kitasato Session at McMaster University　2019/08/14
東日本大震災を通して地域医療の力を考える Invited

菅野武

自治医科大学医学部６年災害医療学講義　2019/06/07
医療者にできること～東日本大震災の経験を経て～ Invited

菅野武

高知大学医学部4年災害・救急医療学講義　2019/06/05
医療者にできること：東日本大震災の被災の実際と課題 Invited

菅野武

宮崎大学地域医療・総合診療医学講座災害医療講演会　2019/06/03
Proton Pump Inhibitor Treatment Initiated Prior to Endoscopy Ic Diagnosis in Upper Gastrointestinal Bleeding: An Updated Cochrane Collaboration Systematic Review and Meta-Analysis of Randomized Controlled Trials International-presentation

Takeshi Kanno, Yuhong Yuan, Colin W. Howden, Paul Moayyedi, Grigorios I. Leontiadis

Digestive Disease Week 2019　2019/05
東日本大震災を通して地域医療の力を考える Invited

Kanno Takeshi

2018/06/29
医療者にできること～東日本大震災の経験を経て～ Invited

菅野武

高知大学医学部4年災害・救急医療学講義　2018/06/27
Notable increase of patients with peptic ulcer disease after Great East Japan earthquake and tsunami in 2011 International-presentation Invited

Takeshi Kanno, Katsunori Iijima, Tomoyuki Koike

Summer School on Stress 2018　2018/06/26
PPI抵抗性NERD患者における逆流時食道内pHと到達部位の検討

阿部泰明, 小池智幸, 菊池弘樹, 大方智樹, 乗田一明, 菅野武, 八田和久, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 下瀬川徹

2018/02/09
Being a doctor in Japan: From the everyday to the extraordinary Invited

Shinya Ito, Takeshi Kanno, James Tiessen

2018/01/31
東北大学病院総合診療外来における簡易心理検査の有用性と関連要因の検討

野崎裕之, 中川高, 中川高, 阿部倫明, 八木橋真央, 甲賀ひとみ, 吉村直仁, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菅野武, 鈴木聡子, 大澤稔, 菊池章子, 黒田仁, 高山真, 奈良正之, 富田博秋, 石井正

2017/11/18
東日本大震災の被災地における医療体験実習は医学生の学習態度や進路に影響を与えるか?

田畑雅央, 荒田悠太郎, 菅野武, 井本博文, 石井正, 加賀谷豊

2017/08/19
災害時における受援体制に必要なこと東日本大震災を通じて-保健師への期待- Invited

Kanno Takeshi

2017/07/19
東日本大震災と地域医療～困難を乗り越え、次につなげるために～ Invited

Kanno Takeshi

2017/07/14
好酸球性胃腸炎を呈した木村病の一例

鵜浦友輔, 菅野武, 八田和久, 淺沼清孝, 宇野要, 浅野直喜, 小池智幸, 今谷晃, 下瀬川徹

日本消化器病学会東北支部第203回例会　2017/07/08
東日本大震災を通して地域医療の力を考える

Kanno Takeshi

2017/06/23
医療者にできること～東日本大震災の経験を経て～ Invited

Kanno Takeshi

2017/05/24
東北大学病院総合診療外来新患におけるうつ度および認知度の実態調査

阿部倫明, 野崎裕之, 中川高, 八木橋真央, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菅野武, 宇佐美修, 大澤稔, 黒田仁, 高山真, 奈良正之, 富田博秋, 石井正

2017/05/13
十二指腸非乳頭部NETの内視鏡的特徴多施設共同研究における胃NETとの比較より

八田和久, 小池智幸, 淺沼清孝, 菅野武, 荒誠之, 浅野直喜, 今谷晃, 下瀬川徹

Gastroenterological Endoscopy　2017/04
早期胃癌ESD後除菌患者における異時性胃癌発生―喫煙を中心とした生活因子との関連性―

八田和久, 阿見麗子, 飯島克則, 小池智幸, 菅野武, 荒誠之, 淺沼清孝, 浅野直喜, 今谷晃, 下瀬川徹

2017/02/17
当院における表在型Barrett食道癌の内視鏡治療成績

菊池弘樹, 小池智幸, 齊藤真弘, 菅野武, 八田和久, 荒誠之, 淺沼清孝, 浅野直喜, 今谷晃, 下瀬川徹

2017/02/17
Great East Japan earthquake and resilience from disaster International-presentation

Takeshi Kanno

2017/02/15
東日本大震災をとして残せることは何か～被災した医療者として～

菅野武

岩手県立病院医学会消化器分科会特別講演　2016/12/02
The analysis for use of percutaneous endoscopic gastrostomy placed prophylactically for head and neck cancer treated with chemoradiotherapy

Ara Nobuyuki, Kanno Takeshi, Hatta Waku, Asanuma Kiyotaka, Asano Naoki, Koike Tomoyuki, Imatani Akira, Shimosegawa Tooru

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　2016/11
Vonoprazan reduces the GERD symptoms in the symptom index positive PPI-refractory NERD

Koike Tomoyuki, Saito Msahiro, Kikuchi Hiroki, Norita Kazuaki, Kanno Takeshi, Hatta Waku, Ara Nobuyuki, Asanuma Kiyotaka, Asano Naoki, Shimosegawa Tooru

2016/11
Factors associated with the development of secondary esophageal squamous cell carcinomas after endoscopic resection for superficial esophageal squamous cell carcinomas

Hatta Waku, Norita Kazuaki, Koike Tomoyuki, Kanno Takeshi, Ara Nobuyuki, Asanuma Kiyotaka, Asano Naoki, Imatani Akira, Shimosegawa Tooru

2016/11
災害時の医療と受援～東日本大震災の経験を通して～

菅野武

国際医療福祉大学大学院災害医療講義　2016/10/07
東日本大震災後の消化性潰瘍の増加とその特徴

菅野武

第7回茨城ヘリコバクター研究会特別講演　2016/09/23
復興と「つながる力」～東日本大震災の経験を通して～

菅野武

第16回日本音楽療法学会学術大会特別企画　2016/09/16
災害対応におけるマネジメントとリーダーシップ Invited

2016/08/27
医療者にできること～東日本大震災の経験を経て～

菅野武

高知大学医学部4年、看護学部1年合同授業　2016/07/13
80歳以上の高齢者における消化性潰瘍の特徴：H. pylori陰性潰瘍の重要性

高橋貴一, 菅野武, 八田和久, 荒誠之, 淺沼清孝, 浅野直喜, 小池智幸, 今谷晃, 伊藤博敬, 大矢内幹, 阿部靖彦, 阿曽沼祥, 下瀬川徹

日本消化器病学会東北支部第201例会　2016/07/08
被災した医療者としての災害医療と受援

菅野武

東北大学大学院公衆衛生看護学分野研究会　2016/07/01
P-CAB 登場後のH. pylori除菌治療の現状

大方英樹, 菅野武, 齊藤真弘, 小池智幸, 下瀬川徹

第22回日本ヘリコバクター学会学術集会　2016/06/24
災害時急性期ストレスと上部消化管

菅野武, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹

第57回日本心身医学会総会パネルディスカッション　2016/06/05
東日本大震災を通して地域医療の力を考える

菅野武

自治医科大学医学部6年災害医療学講義　2016/06/03
上部消化管潰瘍出血に関わる因子の検討

菅野武, 小池智幸, 飯島克則, 下瀬川徹

第91回日本消化器内視鏡学会総会ワークショップ８　2016/05/13
難治性嚥下障害を呈したリンパ球性食道炎の一例

前嶋隆平, 宇野要, 飯島克則, 藤島史喜, 野口哲也, 本田純也, 菅野武, 日下玄, 近藤穣, 八田和久, 荒誠之, 淺沼清孝, 浅野直喜, 小池智幸, 今谷晃, 下瀬川徹

2016/05/13
PPI抵抗性NERD患者における24hr MLL-pHモニタリングの基線値の検討

菊池弘樹, 小池智幸, 乗田一明, 齊藤真弘, 菅野武, 近藤穣, 日下玄, 八田和久, 荒誠之, 淺沼清孝, 宇野要, 浅野直喜, 今谷晃, 下瀬川徹

2016/04
Intense Gastro-Esophageal Reflux May Influence the Localization of Barrett's Adenocarcinoma: Measured by 24-h pH-Impedance Monitoring

Saito Masahiro, Koike Tomoyuki, Kikuchi Hiroki, Norita Kazuaki, Nakagawa Kenichirou, Kanno Takeshi, Kusaka Gen, Kondo Yutaka, Hatta Waku, Ara Nobuyuki, Asanuma Kiyotaka, Uno Kaname, Asano Naoki, Imatani Akira, Iijima Katsunori, Shimosegawa Tooru

2016/04
大規模災害時に問われる地域の力 Invited

菅野武

日本医療マネジメント学会第15回神奈川県支部学術集会市民公開講座　2016/03/05
東日本大震災後の消化性潰瘍の増加と特徴：災害時ストレスとの関連

菅野武

第29回静岡県地域医学研究会シンポジウム　2015/11/15
災害時急性期ストレスと上部消化管：東日本大震災後の消化性潰瘍の増加とその特徴

菅野武, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

第22回日本行動医学会学術総会シンポジウム　2015/10/16
何を伝え、残せるか～東日本大震災の経験を通して～ Invited

菅野武

第15回地域医療と消化器病研究会特別講演　2015/10/09
災害時の医療～東日本大震災の経験に学ぶ～

菅野武

国際医療福祉大大学院災害医療学講義　2015/10/02
困難を乗り越える力～東日本大震災の経験を通して～ Invited

菅野武

第13回兵庫県立病院学会基調講演　2015/09/05
いまを生き、明日へとつなぐ～東日本大震災の経験を通して～ Invited

菅野武

第14回茨城県地域医療学術集会特別講演　2015/08/23
医師にできること～東日本大震災の経験を通して～

菅野武

高知大学医学部4年災害・救急医療学講義　2015/06/03
特発性潰瘍の特徴と長期経過

菅野武, 飯島克則, 阿部靖彦, 大矢内幹, 阿曽沼祥

2015/05/30
ストレスと消化器疾患機能性消化管障害の病態における東日本大震災に伴うストレスの影響

菅野武, 飯島克則, 朝倉徹

2015/04/23
精神的ストレスは、消化性潰瘍の独立した成因であり、災害時潰瘍出血の危険因子となる：東日本大震災後の消化性潰瘍の増加とその特徴

菅野武

JMU in Tohoku　2015/02/21
今を生き、明日へとつなぐ～東日本大震災を通して考える～ Invited

菅野武

第53回衛生教育大阪大会第57回公衆衛生大阪大会　2015/02/12
地域医療と東日本大震災～今を生き、明日へとつなぐ～

菅野武

第50回鹿児島県立病院学会特別講演　2014/10/18
DPAT先遣隊活動の意義～東日本大震災の経験を通して～

菅野武

DPAT（災害派遣精神医療チーム）先遣隊研修　2014/07/19
医師にできること

菅野武

高知大学医学部4年災害・救急医療学講義　2014/06/25
Increasing of idiopathic peptic ulcers in Japan: Multicenter-prospective study

Takeshi Kanno, Kastunori Iijima, Tomoyuki Koike, Yasuhiko Abe, Motoki Ohyauchi, Hirotaka Ito, Sho Asonuma, Tooru Shimosegawa

第87回日本消化器内視鏡学会総会　2014/05/15
当院における頭頸部癌治療後消化管狭窄への内視鏡的バルーン拡張術の検討

前嶋隆平, 飯島克則, 本田純也, 白木健悠, 中川健一郎, 金笑奕, 菅野武, 新海洋彦, 伏谷淳, 近藤穣, 八田和久, 遠藤博之, 荒誠之, 宇野要, 浅野直喜, 小池智幸, 今谷晃, 下瀬川徹

2014/05
今を生き、明日へとつなぐ～東日本大震災の経験を通して～

菅野武

PCBM in Minamisanriku（プライマリケア勉強会）　2014/03/22
東日本大震災は日本の持つ問題を前倒しにした～この経験を社会の財産にできるか～ Invited

菅野武

東京大学医療産業サミット第11回朝食会講演　2014/03/12
今を生き、明日へとつなぐ～東日本大震災の経験を通して～ International-presentation Invited

菅野武

未来医療研究人材養成拠点形成事業『東京大学医療イノベーションイニシアティブ』オープニングシンポジウム特別講演　2014/03/11
「東北大学病院における除菌治療」「特発性潰瘍について」

菅野武

ラベキュア・ラベファイン新発売記念講演会 in 宮城　2014/02/27
高齢者に対するサムスカ錠の使用経験

菅野武

丸森地域医療連携勉強会　2014/01/31
ストレスと消化性潰瘍

菅野武

あすか製薬社内勉強会講義　2014/01/28
今を生き、明日へとつなぐ～東日本大震災に被災した医療者として

菅野武

さざなみ会冬季学術集会基調講演　2013/12/21
医師に出来ること」～東日本大震災の経験を通して～

菅野武

東北大学医学部1年生医療入門2 講義　2013/11/28
Experience taken by a tsunami-stricken hospital (Shizugawa public hospital) International-presentation

Takeshi Kanno

ACEM2013 アジア救急医学会　2013/10/24
特発性潰瘍の頻度調査:多施設共同・前向き研究

菅野武, 飯島克則, 小池智幸, 下瀬川徹, 阿部靖彦, 大矢内幹, 伊藤博敬, 阿曽沼祥

2013/10/09
医師にできること

菅野武

高知大学医学部4年災害・救急医療学講義　2013/07/24
寄り添う医療～東日本大震災の体験を通して～

菅野武

岡山県プライマリケア学会基調講演　2013/07/20
当科におけるH. pylori除菌療法の治療成績

菅野武, 小池智幸, 飯島克則, 阿部靖彦, 下瀬川徹

第19回日本ヘリコバクター学会　2013/06/28
Peptic ulcer after East Japan Earthquake and Tsunami: Role of stress in ulcer pathogenesis International-presentation

Takeshi Kanno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Norihiro Shimada, Tatsuya Hoshi, Nozomu Sano, Motoki Oyauchi, TomoakI Atsumi, Syo Asonuma, Tooru Shimosegawa

Tohoku-NIH symposium　2013/05/10
3.11を経験して医療に携わる意義～東日本大震災の経験とそれから

菅野武

ノバルティスファーマ新人研修会講義　2013/04/18
高齢者における消化性潰瘍と心因性ストレスとの関連―東日本大震災前後の集計結果から―

飯島克則, 菅野武, 下瀬川徹

2013/03/21
残された命をつなぐ～志津川病院での被災とそれから～

菅野武

ノバルティス社内勉強会講演　2013/01/22
被災した医療者として Invited

菅野武

第61回千葉県国民健康保険直営診療施設医療学会市民公開セミナーシンポジウム　2012/11/30
被災病院での体験とストレス : 津波を直接経験した医療者として

菅野武

日本心療内科学会誌　2012/11/20
東日本大震災後の出血性潰瘍のリスクについての検討

菅野武, 阿部靖彦, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

2012/10/11
食道胃接合部腺癌・噴門部癌に対する内視鏡治療後の予後に関する検討

中川健一郎, 小池智幸, 宇野要, 白木健悠, 金笑奕, 菅野武, 荒誠之, 浅野直喜, 阿部靖彦, 飯島克則, 今谷晃, 下瀬川徹

2012/10
食道表在癌(扁平上皮癌・腺癌)に対する内視鏡治療後の予後に関する検討

中川健一郎, 小池智幸, 宇野要, 白木健悠, 金笑奕, 菅野武, 荒誠之, 浅野直喜, 阿部靖彦, 飯島克則, 今谷晃, 下瀬川徹

2012/10
いのちに寄り添う医療～被災した医療者として生と死を思う Invited

菅野武

第25回日本サイコオンコロジー学会学術集会シンポジウム７がん診療と災害医療　2012/09/22
東日本大震災における急性期看護の実際と課題 Invited

菅野武

第43回日本看護学会成人看護Ⅰ学術集会特別企画シンポジウム　2012/09/21
「被災者」から「震災経験者」に変わる日 Invited

菅野武

エーザイ社内勉強会講演　2012/08/03
苦難の時こそ、医療者としての思いが現れる Invited

菅野武

第44回日本医学教育学会教育講演　2012/07/27
医師に出来ること～東日本大震災の経験を通して

菅野武

高知大学医学部4年災害・救急医療学講義　2012/06/27
「被災者」から「震災経験者」になる日

菅野武

日本麻酔科学会第59回学術集会招待講演　2012/06/07
Peptic ulcer after East Japan Earthquake and Tsunami : Role of stress in ulcer pathogenesis International-presentation

Takeshi Kanno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Norihiro Shimada, Tatsuya Hoshi, Nozomu Sano, Motoki Oyauchi, TomoakI Atsumi, Syo Asonuma, Tooru Shimosegawa

第83回日本消化器内視鏡学会総会国際ポスターセッション　2012/05/12
東日本大震災1年後の現状と課題「被災者」から「震災経験者」になる日公立志津川病院での東日本大震災の体験を通して Invited

菅野武

2012/05/12
東日本大震災被災地域における消化性潰瘍症例の検討

菅野武, 阿部靖彦, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

日本消化管学会総会学術集会プログラム・抄録集　2012/04/21
「被災者」から「震災経験者」になる日公立志津川病院での東日本大震災の体験を通して Invited

菅野武

2012/03/14
東日本大震災被災地域における消化性潰瘍症例の検討

菅野武, 阿部靖彦, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

第8回日本消化管学会総会学術集会会長特別企画WS-3　2012/02/10
東日本大震災後の消化性潰瘍症例についての検討

菅野武, 阿部靖彦, 飯島克則, 小池智幸, 島田憲宏, 星達也, 佐野望, 大矢内幹, 熱海智章, 阿曽沼祥, 下瀬川徹

第148回消化器内視鏡学会東北支部例会　2012/02/03
被災病院での体験とストレス~津波を直接経験した医療者として Invited

菅野武

2011/11/27
被災病院(公立志津川病院)での体験と対応 Invited

菅野武

2011/10/22
被災病院（公立志津川病院）での体験と対応 Invited

菅野武

自治医大シンポジウム特別講演　2011/09/02
Local response to the earthquake and its results～Experience and measures taken by a disaster-stricken hospital (Shizugawa public hospital) International-presentation Invited

Takeshi Kanno

International Surgical Week ISW2011International Surgical Week ISW2011"　2011/09/01
被災病院（公立志津川病院）での体験と対応 Invited

菅野武

第47回日本腹部救急医学会総会会長企画講演　2011/08/11
被災病院の体験と対応 Invited

菅野武

日本消化器病学会東北支部第191例会緊急企画「被災現場からの報告」講演　2011/07/08
２．被災病院の体験と対応 Invited

菅野武

第97回日本消化器病学会総会緊急特別企画「東日本大震災現地からの報告と復興への課題」講演　2011/05/14
災害医療マニュアルの見直し―岩手宮城内陸地震の経験から―

内田孝, 菅野武

日本集団災害医学会誌　2009/12/31
岩手・宮城内陸地震の経験~被災地内病院での初期対応

菅野武, 内田孝

日本集団災害医学会誌　2008/12/31

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Industrial Property Rights 6

内視鏡手技訓練具

松本睦, 菅野武, 荒田悠太郎, 正宗淳

実用新案登録第3232990号

Property Type: Utility model
粘膜組織モデル

松本睦, 見山彰, 菅野武, 荒田悠太郎, 正宗淳

Property Type: Patent
止血を含む手技を練習するために用いられる潰瘍模型

見山彰, 荒井亨, 佐々木崇, 菅野武, 荒田悠太郎, 正宗淳

Property Type: Patent
粘膜モデル

宮脇まなみ, 福田祐子, 菅野武, 荒田悠太郎, 正宗淳

Property Type: Patent
十二指腸乳頭モデル

福田祐子, 長尾圭介, 菅野武, 荒田悠太郎, 滝川哲也, 畑山裕, 正宗淳

Property Type: Patent
模擬粘液被覆粘膜組織モデル

福田祐子, 菅野武, 荒田悠太郎, 正宗淳

Property Type: Patent

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Research Projects 13

質の高い学習が可能な胆膵内視鏡シミュレータモデルの開発と学習プログラムの構築

滝川哲也, 菅野武, 畑山裕

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

2025/04 - 2028/03
Development of interactive online learning that specializes in cultivating the clinical diagnostic skills necessary for clinicians in the age of AI

Yasushi Matsuyama, Yoshikazu Asada, Takeshi Kanno

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

2025/04 - 2028/03
メタゲノム解析による人体の全消化管細菌叢の同定と臨床応用へのアプローチ

石沢興太菅野武高山真青木裕一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2023/04 - 2028/03
市中施術所および医療機関におけるCOVID-19後遺症の特徴の抽出と鍼灸治療の効果の検討

金子聡一郎, 菅野武, 有田龍太郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2023/04 - 2027/03
合併症を再現できる内視鏡手技シミュレータを展開し、有効な学習プログラムを構築する

菅野武, 太田信, 荒田悠太郎

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（C）

2022/04 - 2025/03
急性出血性直腸潰瘍の疫学研究多施設共同前向きコホート研究の基盤構築

才津旭弘, 菅野武

Offer Organization: 地域医療振興協会

System: 第37回地域保健医療に関する研究助成

2024/09 -
口腔から上部消化管におよぶ腸内細菌叢と、窒素酸化物代謝活性から紐解くディスペプシア症状

菅野武有田龍太郎石沢興太小池智幸

Offer Organization: 公益財団法人鈴木謙三記念医科学応用研究財団

System: 令和4年度調査研究助成金

2022/12 - 2024
Dyspepsiaを上部消化管細菌叢とNitrate reductase activityで読み解く前向き研究

菅野武有田龍太郎石沢興太小池智幸鈴木直生

Offer Organization: 公益財団法人艮陵医学振興会

System: 医学研究奨励賞

2022/09 - 2024
丸森町国民健康保険丸森病院における大腸がん検診未受診者への積極的な便潜血検査の意義に関する研究事業 Competitive

大友正隆(代表), 菅野武(分担), 菅谷涼(分担)

Offer Organization: 公益財団法人地域社会振興財団

System: 長寿社会づくりソフト事業（特定事業）ア地域医療技術向上推進事業研究事業

2021/04 - 2022/03
Development of a comprehensive ERCP simulator

Offer Organization: ＪＦＥ（The Japanese Foundation for Research and Promotion of Endoscopy)

System: ＪＦＥ（The Japanese Foundation for Research and Promotion of Endoscopy) Research grant B

2021/04 - 2022/03
食道癌および胃癌の実数と組織型の変化に関する疫学研究

菅野武

Offer Organization: 宮城県公衆衛生協会

System: 令和2年度宮城県公衆衛生研究振興基金

2020/07 - 2022/03
合併症が再現でき消化管の層構造をもつ、安全な内視鏡治療手技モデルを開発する Competitive

菅野武(代表), 荒田悠太郎(分担), 加賀谷豊(分担)

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（B)

2019/04 - 2022/03
内視鏡的止血術のシミュレーションモデルを構築し、安全な学習方法を確立する Competitive

菅野武

Offer Organization: 文部科学省

System: 科学研究費助成事業若手研究（Ｂ）

2017/04 - 2019/03

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Social Activities 104

セレンディピティこそがイノベーションを生む：被災の経験を越え仲間と共にレジリエンスを育む

オンライン講演会

2025/07/04 -

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中小企業のM&A仲介企業の若手営業関係者、及びパラダイムシフト社のメンバーに対するプロフェッショナリズムに関するオンライン勉強会謝金なし
災害医療と地域医療～生きのびた命をつなぐ～

令和7年度自治医科大学松韻会総会講演会

2025/05/17 -
"Extra" Tohoku Medical Cafe 緩和ケア医と医学部教授の対話で地域のwell-beingを掘り下げる

Well-Being Conference with "Mori"　青葉山公園仙臺緑彩館

2025/03/20 -
出会いを活かすDecision Making 自己実現と医療者のプロフェッショナリズム

若手医師メンタリングプログラム「NANIMON」

2025/02/26 -
生きのびる災害医療～被災した医療者として次へつなぐ～

自治医科大学第53回薬師祭（学園祭）

2024/10/12 -
わが町が災害に遭ったら～支援を受け止める「受援」を考えよう～

Tohoku Medical Cafe

2024/07/02 -
被災医師の12年

３・１１祈りのコンサート　電力ホール

2023/03/11 -
過去に学び今を生き明日に備える～大規模災害からのレジリエンス～

東北DMAS第4回研修会　仙台市福沢市民センター

2023/02/11 -
地域医療と災害医療：被災した医療者としての10年、レジリエンス

東北大学小児科イブニングカンファレンス

2023/01/24 -
過去に学び今を生き明日に備える～大規模災害からのレジリエンス～

３１１『伝える／備える』次世代塾

2021/05/15 -
与えられた「いのち」をどう生きますか？～東日本大震災を経験した医師として～

いのちの授業

2021/02/22 -
過去に学び今を生き明日に備える～大規模災害からのレジリエンス～

2020年度一般向け学習講座

2020/10/17 -
過去に学び今を生き明日へとつなぐ～被災とレジリエンス～

JAMSNET東京講演会　早稲田大学9号館

2019/07/28 -
Experience and Resilience from Great East Japan earthquake and Tsunami

2019/05/25 -
過去に学び今を生き明日へとつなぐ～被災とレジリエンス～

平成30年若手職員研修会

2019/02/20 -
Experience and Resilience from Great East Japan earthquake and Tsunami

2018/11/10 -
困難を乗り越える力：東日本大震災の経験を通して

The Japanese American Association of New York

2018/10/06 -
初めから特別な人間なんていない～東日本大震災で被災した医療者～

The Japanese Canadian Cultural Centre

2018/08/20 -
困難を乗り越える力：東日本大震災の経験を通して

Toronto, Canada

2018/05/06 -
初めから特別な人間なんていない～東日本大震災で被災した医療者～

U-18東北次世代リーダーカンファレンス

2017/08/19 -
東日本大震災と地域医療～困難を乗り越え、次につなげるために～

2017/06/12 -
大規模災害時に問われる地域の力～東日本大震災の経験を通して～

2017/06/10 -
大規模災害時に問われる地域の力～東日本大震災の経験を通して～

2017/04/08 -
医師にできることは何か～東日本大震災を経て考える～

2016/10/22 -
寄り添う医療とは～東日本大震災の経験を経て～

2016/09/22 -
今を生き、明日へとつなぐ～東日本大震災の経験を通して考える～

2016/09/03 -
困難を乗り越える力～地域医療と東日本大震災～

2015/11/15 -
生き抜く災害医療～東日本大震災の経験に学ぶ～

戦略的災害医療プロジェクト講演会

2015/10/30 -
今を生き、明日へとつなぐ～東日本大震災を通して考える～

仙台市医師会

2015/06/16 -
地域医療と東日本大震災～被災した医療者として～

2015/05/15 -
やがて来る災害を生き抜くには～東日本大震災の経験に学ぶ～

2015/03/21 -
東日本大震災の経験から日本の課題を考える

日経ソーシャルイニシアチブセミナー基調講演

2015/03/12 -
寄り添い支える～東日本大震災と地域医療～

2015/02/28 -
医療といのち～東日本大震災を通して考える～

2014/12/26 -
寄り添い支える～東日本大震災から学ぶ～

榴ヶ岡老壮大学特別講演

2014/11/19 -
やがて来る災害を生き抜くには～東日本大震災の経験に学ぶ～

2014/11/15 -
震災から学び、明日へとつなぐ～次の南海地震に備えて～

災害医療講演会 in いの特別講演

2014/11/15 -
今を生き、明日へとつなぐ～東日本大震災を通して考える～

第1回高度先進医療薬剤師講座

2014/11/09 -
Resilience：我們如何記取311的教訓

2014/10/04 -
今を生き、明日へとつなぐ～東日本大震災を通して考える～

2014/09/17 -
寄り添い支える～地域医療と東日本大震災～

地域に寄り添う医師・医学生キャリアアップセミナー特別講演

2014/08/16 -
震災から学び、明日へとつなぐ～災害時のコミュニティリーダー、医療者の目指すもの～

2014/07/30 -
今を生き、明日へとつなぐ～東日本大震災の経験を通して～

2014/06/19 -
今を生き、明日へとつなぐ～東日本大震災の経験を通して～

2014/04/05 -
「医師にできること」～東日本大震災を通して考える～

2014/03/29 -
今を生き、明日へとつなぐ～被災した医療者として～

2014/03/02 -
寄り添い支える～東日本大震災の経験を通して～

2014/02/26 -
今を生き、明日へとつなぐ～東日本大震災の経験を通して～

2014/02/22 -
「医師にできること」～東日本大震災を通して考える～

医師を志す高校生支援事業

2014/01/11 -
地域医療と東日本大震災～被災した医療者として～

2013/11/23 -
地域医療と東日本大震災～被災した医療者として～

2013/11/02 -
寄り添う医療～東日本大震災の経験を通して～

2013/10/19 -
今を生き、明日へとつなぐ～東日本大震災の経験を通して～

2013/10/12 -
今を生き、明日へとつなぐ～地域医療と東日本大震災～

2013/09/28 -
地域医療と東日本大震災～公立志津川病院での経験を通して～

2013/09/21 -
寄り添う医療～東日本大震災の経験を通して～

2013/09/17 -
寄り添い支える～東日本大震災の経験を経て～

2013/08/27 -
地域医療と東日本大震災～公立志津川病院での体験とそれから～

2013/08/17 -
今を生き、明日へとつなぐ～被災した医療者として～

2013/07/30 -
高知県災害医療行政に関する講演会

2013/07/25 -
困難の先にさす光～公立志津川病院での被災とそれから～

2013/06/29 -
地域医療と東日本大震災～志津川病院での体験を通じて～

2013/06/22 -
苦難に学ぶ～東日本大震災の経験とそれから～

2013/06/14 -
志津川病院での被災とそれから～東日本大震災の体験を通して～

伊具地区学校保健会総会講演

2013/06/13 -
寄り添う医療～公立志津川病院での被災とそれから～

2013/05/08 -
被災した医療者として～南三陸町での経験とそれから

2013/03/30 -
寄り添う医療～公立志津川病院での被災とそれから～

2013/03/16 -
「被災者」から「震災経験者」に変わる日～東日本大震災の経験を通して

2013/03/09 -
寄り添う医療～東日本大震災の経験を通して～

2013/03/05 -
寄り添い支える～東日本大震災の経験を通して～

2013/02/24 -
寄り添う医療～志津川病院での被災とそれから～

2013/02/22 -
苦難の時こそ、医療者としての思いが現れる～公立志津川病院での東日本大震災の経験を通して～

2013/02/21 -
東日本大震災を通して地域の医療福祉を考える～被災した医療者として

2013/02/17 -
明日への希望を～「被災者」から「震災経験者に変わる日」～

2013/02/16 -
寄り添う医療～東日本大震災の経験を通して～

2013/01/31 -
残された命をつなぐ～志津川病院での被災とそれから

市民のためのサイエンス講座2012 講演

2012/12/20 -
「医師に出来ること」

2012/11/24 -
「被災者」から「震災経験者」に変わる日

2012/11/17 -
「出来ることを果たす」～東日本大震災の経験を通してプロフェッショナルとしての自覚を考える

2012/10/23 -
「被災者」から「震災経験者」に変わる日

2012/10/20 -
寄り添う～東日本大震災の経験を通して

2012/09/30 -
東日本大震災に被災した医療の現場から

2012/09/11 -
「被災者」から「震災経験者」に変わる日

2012/09/05 -
院内での急性期対応とその後

2012/08/31 -
寄り添う医療～被災した医療者として

2012/08/30 -
Experience and measures taken by a disaster-stricken hospital

HLB Japanレセプション講演

2012/08/28 -
「被災者」から「震災経験者」に変わる日

2012/07/28 -
医師に出来ること～東日本大震災の経験を通して

2012/07/21 -
「被災者」から「震災経験者」になる日

2012/07/03 -
「被災者」から「震災経験者」になる日

2012/06/02 -
より添い支える～東日本大震災の経験を通して

2012/05/19 -
「寄り添う」とは～東日本大震災の経験を通して考える

2012/05/15 -
医師に出来ること～東日本大震災の経験を通して

ウェルカムみやぎ基調講演

2012/04/06 -
「被災者」から「震災経験者」へ変わる日

2012/03/27 -
被災者」から「震災経験者」へ変わる日

朝日復興フォーラム特別講演

2012/02/16 -
被災病院での体験と対応

2012/01/27 -
被災病院での体験と対応

2012/01/21 -
地域医療の現場とは～東日本大震災を通して考える

医師を志す高校生支援事業講演

2012/01/07 -
時に癒し、しばしば支え、つねに慰む―地方病院が被災したとき

2011/11/26 -
公立志津川病院での体験と対応～地方病院が被災したとき～

2011/11/22 -
被災地の経験から学ぶ地域医療と震災～地方病院が被災したとき～

2011/11/13 -
被災病院（公立志津川病院）での体験と対応

2011/10/08 -
被災病院（公立志津川病院）での体験と対応

2011/09/05 -
被災病院での医師としての体験、対応

2011/07/26 -

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Media Coverage 1

メディア関係

テレビ、ラジオ、雑誌掲載など

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東北大学医学部広報、一條様のご助力にて一覧を作成しております。

Academic Activities 12

災害後に注目すべき内科系疾患～災害後消化性潰瘍を中心に

2020/02/21 -
医療者にできること～東日本大震災の経験を経て～

2019/06/05 -
医療者にできること：東日本大震災の被災の実際と課題

2019/06/03 -
喪失とレジリエンス～被災した医療者として～

2019/02/21 -
医療者にできること～東日本大震災の経験を経て～

2018/06/27 -
復興と「つながる力」～東日本大震災の経験を通して～

2017/03/01 -
ガイドラインを意識した上部消化管診療と最近の話題

2017/02/10 -
東日本大震災の津波被害と復興

2016/11/20 -
大規模災害と地域医療～東日本大震災の経験を通して～

2016/08/23 -
生き抜く災害医療～東日本大震災の経験に学ぶ～

2015/10/31 -
やがて来る災害を生き抜くには～東日本大震災の経験に学ぶ～

2015/07/31 -
被災病院（公立志津川病院）での体験と対応

2011/09/04 -

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