Details of the Researcher

PHOTO

Yosuke Kakisaka
Section
Graduate School of Medicine
Job title
Associate Professor
Degree

  • 博士（医学）（東北大学）

e-Rad No.
90400324

Research History 5

  • 2024/04 - Present
    東北大学 医学系研究科・医学部　医学教育推進センター　准教授

  • 2013/04 - 2024/03
    Tohoku University Hospital　Department of Epileptology

  • 2012/08 - 2013/03
    みやぎ県南中核病院　小児科

  • 2012/04 - 2012/07
    東北大学病院　小児科

  • 2010/03 - 2012/03
    Cleveland Clinic Foundation

Education 3

  • Tohoku University　Graduate School of Medicine

    2006/04 - 2010/03

  • Fukushima Medical University　School of Medicine

    1994/04 - 2000/03

  • 宮城県仙台第一高等学校

    1991/04 - 1994/03

Committee Memberships 1

  • 日本てんかん学会　「てんかん研究」編集委員会

    2019/12 - Present

Professional Memberships 4

  • 日本医学教育学会

  • JAPAN PEDIATRIC SOCIETY

  • 日本頭痛学会

  • JAPAN EPILEPSY SOCIETY

Research Interests 8

  • 高校生に対する発信法（ポスター・口演・論文化）教育

  • ジェームス・ヤング「アイデアのつくり方」を援用した発想法・キャリア教育

  • 小児科学

  • てんかん学

  • 「症例報告執筆」教育

  • pediatric migraine and its equivalent

  • 遠隔医学教育

  • 脳磁図

Research Areas 1

  • Life sciences / Fetal medicine/Pediatrics /

Awards 11

  1. Good teacher賞

    2025/05　東北医科薬科大学医学部　医学英語Ⅴ

  2. 令和3年度医学部・医学系研究科教育貢献賞

    2022/03　東北大学医学部

  3. Marquis Who's Who in the World, 2019, 掲載

    2019/07　Marquis Who's Who Ventures LLC

  4. 2018年度 東北大学医学部 The Best Teacher Award

    2019/05　東北大学

  5. 2016年 度東北大学医学部 The Best Teacher Award

    2017/04　東北大学

  6. 東北大学小児科 荒川賞

    2014/11　東北大学小児科

  7. 東北大学小児科 優秀論文賞

    2012/12　東北大学小児科

  8. 第44回日本てんかん学会JUHN AND MARY WADA 奨励賞

    2012/10　日本てんかん学会

  9. 第42回日本てんかん学会優秀ポスター賞

    2008/10　日本てんかん学会

  10. Young Investigator Award, 16th International Conference on biomagnetism

    2008/08　Biomag

  11. 第40回日本てんかん学会優秀ポスター賞

    2006/09　日本てんかん学会

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Papers 161

  1. 動画記録を活用し教員と模擬患者からの複合的フィードバックを導入した医療面接教育プログラム構築の試み． Peer-reviewed

    柿坂庸介, 齋木由利子, 岩﨑淳也, 田中淳一

    東北医誌　in press　2025/12

  2. Understanding enacted and felt stigma in temporal lobe epilepsy. Peer-reviewed

    Ogawa M., Fujikawa M., Tasaki K., Kakisaka Y., Jin K., Nakasato N.

    Epilepsy Behav　171　110620　2025/07

  3. Neuromagnetic evidence of the foot primary somatosensory area in the frontal cortex. Peer-reviewed

    Ishida M., Katayama H., Kakisaka Y., Jin K., Nakasato N.

    Clin Neurophysiol　176　2110767　2025/05

  4. Acute Respiratory Failure Caused by Lateral Medullary Infarction - An Unknown Condition with Varied Etiology and Requiring Special Vigilance: A Case Series.

    Ako Miyata, Ryosuke Doijiri, Kohei Takikawa, Takuji Sonoda, Naoya Yamazaki, Shuhei Egashira, Kiyotaka Oi, Kanako Kato, Momoyo Oda, Yosuke Kakisaka, Takahiko Kikuchi

    Internal medicine (Tokyo, Japan)　64　(6)　947-951　2025/03/15

    DOI： 10.2169/internalmedicine.3993-24 　

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    Acute respiratory failure (ARF) due to lateral medullary infarction (LMI) can be a fatal condition, although its details remain unclarified. To clarify clinical aspects of ARF due to LMI, we reviewed eight applicable cases treated in a tertiary hospital. Of them, we focused on the detailed clinical course of one case. We clarified that even patients with a serious clinical course may have no apparent magnetic resonance imaging abnormalities in respiratory control centers at the initial examination. We should be mindful that respiratory monitoring is necessary even without infarction of regions responsible for respiratory control at the initial presentation.

  5. Adult-onset epilepsy with startle-induced seizure after febrile infection-related epilepsy syndrome;A case report. Peer-reviewed

    Konomatsu K., Kakisaka Y., Jin K., Fujiwara Y., Kubota T., Ogawa M., Ishida M., Ukishiro K., Ono H., Kaneko K., Sugeno N., Aoki M., Nakasato N.

    Epileptic Disord　27　451-456　2025/03

  6. 協働的ICTツールを活用した医学教育の可能性． Peer-reviewed

    柿坂庸介, 平田理絵

    福島医学　in press　2025/03

  7. Complete Corpus Callosotomy Brings Worthwhile Seizure Reduction in Both Pediatric and Adult Patients. International-journal

    Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

    Neurosurgery　96　(2)　410-415　2025/02/01

    DOI： 10.1227/neu.0000000000003092 　

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    BACKGROUND AND OBJECTIVES: The influence of the age at which complete corpus callosotomy (CC) surgery is performed on seizure outcomes remains unclear. This study aimed to evaluate the age-dependent aspects of long-term seizure outcomes after complete CC. METHODS: We reviewed 41 patients who underwent one-stage complete CC. Seizure outcomes were analyzed for age at epilepsy onset and at complete CC, focal MRI abnormality, and etiology. RESULTS: The median age was 7 months at epilepsy onset and 93 months at complete CC. The median follow-up duration was 67 months. Sixteen patients had focal MRI lesions and 4 had only general atrophy. Etiology was identified in 20 patients. For overall seizure outcomes (N = 41), complete seizure freedom was achieved in 5 patients, excellent seizure reduction (>80%) in 11, good (50%-80%) in 5, and poor (<50%) in 20. Freedom was correlated with younger age at complete CC and unknown etiology ( P ≤ .05). Freedom was only achieved in patients aged younger than 7 years. Worthwhile (≥50%, freedom, excellent, and good) and not worthwhile (<50%, poor) overall seizure reduction showed no statistical difference in age at complete CC. No related factor was found for worthwhile overall seizure reduction. For drop attack outcomes (N = 31), freedom was achieved in 22 cases, excellent in 5, and poor in 4. Freedom was correlated with younger age at complete CC ( P < .05) although freedom was achieved in 4 of 7 patients older than 20 years. Age at complete CC showed no statistical difference between worthwhile (≥50%) and not worthwhile (<50%) drop attack reduction. Worthwhile drop attack reduction was correlated with unknown etiology ( P < .05). Complications were mild and transient. CONCLUSION: Complete CC is an excellent surgical option based on favorable seizure outcomes and acceptable complications in our present study.

  8. 症候学と臨床推論の統合的学修を目指した講義アーカイブ集構築の試み. Peer-reviewed

    柿坂庸介, 齋木由利子, 岩﨑淳也, 田中淳一

    東北医誌　136　73-76　2024/12

  9. Achievement and Chanllenges in China's Standardized Residency Training System Peer-reviewed

    YU Chun, Ukishiro K, Kakisaka Y, Nakasato N

    55　493-495　2024/12

  10. Individual and relational factors related to disclosure of epilepsy in the workplace

    Ogawa M, Fujikawa M, Tasaki K, Ukishiro K, Kakisaka Y, Jin K, Nakasato N

    Ogawa M;Fujikawa M;Tasaki K;Ukishiro K;Kakisaka Y;Jin K;Nakasato N　160　110079-110079　2024/10

  11. 深層学習を用いた単チャネル脳波のdensity spectral arrayによるてんかん発作と心因性非てんかん発作の鑑別

    此松 和俊, 柏田 祐樹, 久保田 隆文, 神 一敬, 高橋 健人, 黒田 直生人, 浮城 一司, 柿坂 庸介, 青木 正志, 中里 信和

    てんかん研究　42　(2)　584-584　2024/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  12. Somatosensory evoked spikes in normal adults detected by magnetoencephalography. International-journal

    Makoto Ishida, Yosuke Kakisaka, Kazutaka Jin, Akitake Kanno, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　164　19-23　2024/05/22

    DOI： 10.1016/j.clinph.2024.05.006 　

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    OBJECTIVE: Somatosensory evoked spikes (SESs) have been reported only in children aged under 14 years and are considered as an age-dependent phenomenon. However, we detected SESs in adult patients with epilepsy using magnetoencephalography (MEG). The present study investigated whether MEG can detect SESs in normal adults. METHODS: Spontaneous MEG was recorded during measurement of somatosensory evoked fields (SEFs) for bilateral electrical median nerve stimuli in 30 healthy adults. RESULTS: Bilateral SESs were observed in 10 adults but none in the other 20 subjects. SESs consisted of one or two peaks, and the first peak latency corresponded to that of the second peak (M2) of SEFs. The first SES peak was identical to the M2 in isofield map pattern, as well as location and orientation of the equivalent current dipole (ECD). M2 ECD strength in the 10 subjects with SESs was larger (p <0.0001) than in 20 without SESs. CONCLUSIONS: All-or-nothing detection of bilateral SESs by MEG in normal adults must depend on the signal-to-noise issue of symmetrical SEFs and background brain activity. SIGNIFICANCE: Our results further confirm the higher sensitivity of MEG compared to scalp EEG for the detection of focal cortical sources tangential to the scalp such as SESs.

  13. Remission of startle epilepsy provoked by acoustic stimuli following complete callosotomy: A case study. International-journal

    Kazushi Ukishiro, Shin-Ichiro Osawa, Yosuke Kakisaka, Kazutaka Jin, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

    Epileptic disorders : international epilepsy journal with videotape　2024/05/07

    DOI： 10.1002/epd2.20238 　

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    Herein, we present the case of a 21-year-old man with a history of generalized tonic seizures since the age of 4 years. These seizures occurred either spontaneously or could be provoked by auditory stimuli such as the sounds of a vacuum cleaner or an electric shaver. Despite trials with 10 different anti-seizure medications, his seizures remained refractory. Interictal electroencephalography (EEG) revealed generalized epileptiform activity, whereas ictal EEG showed a generalized attenuation pattern. Magnetic resonance imaging revealed extensive chronic infarctions, predominantly in the bilateral cerebral watershed areas. At the age of 17, the patient underwent a one-stage complete callosotomy, which only achieved remission of auditory-provoked seizures. Based on this experience and published reports, we propose that the posterior corpus callosum, particularly the isthmus and anterior splenium, may be involved in seizures caused by unexpected sound stimuli.

  14. Genetic generalized epilepsy with catecholaminergic polymorphic ventricular tachycardia complicated by ryanodine receptor 2 variant: A case report

    Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Takeshi Aiba, Shin Takahashi, Hironobu Ueda, Takafumi Kubota, Temma Soga, Kazushi Ukishiro, Masashi Aoki, Nobukazu Nakasato

    Seizure: European Journal of Epilepsy　117　284-287　2024/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.seizure.2024.04.003 　

    ISSN： 1059-1311

  15. “Caterpillar sign” in corpus callosum associated with curvilinear pericallosal lipoma in MRI: A case report. Peer-reviewed

    Konomatsu K, Kakisaka Y, Sato S, Kubota T, Soga T, Ukishiro K, Jin K, Mugikura S, Aoki M, Nakasato N

    Radiol Case Rep　19　2058-2061　2024/03

  16. Ongoing EEG artifact correction using blind source separation. International-journal

    Nicole Ille, Yoshiaki Nakao, Shumpei Yano, Toshiyuki Taura, Arndt Ebert, Harald Bornfleth, Suguru Asagi, Kanoko Kozawa, Izumi Itabashi, Takafumi Sato, Rie Sakuraba, Rie Tsuda, Yosuke Kakisaka, Kazutaka Jin, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　158　149-158　2024/01/04

    DOI： 10.1016/j.clinph.2023.12.133 　

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    OBJECTIVE: Analysis of the electroencephalogram (EEG) for epileptic spike and seizure detection or brain-computer interfaces can be severely hampered by the presence of artifacts. The aim of this study is to describe and evaluate a fast automatic algorithm for ongoing correction of artifacts in continuous EEG recordings, which can be applied offline and online. METHODS: The automatic algorithm for ongoing correction of artifacts is based on fast blind source separation. It uses a sliding window technique with overlapping epochs and features in the spatial, temporal and frequency domain to detect and correct ocular, cardiac, muscle and powerline artifacts. RESULTS: The approach was validated in an independent evaluation study on publicly available continuous EEG data with 2035 marked artifacts. Validation confirmed that 88% of the artifacts could be removed successfully (ocular: 81%, cardiac: 84%, muscle: 98%, powerline: 100%). It outperformed state-of-the-art algorithms both in terms of artifact reduction rates and computation time. CONCLUSIONS: Fast ongoing artifact correction successfully removed a good proportion of artifacts, while preserving most of the EEG signals. SIGNIFICANCE: The presented algorithm may be useful for ongoing correction of artifacts, e.g., in online systems for epileptic spike and seizure detection or brain-computer interfaces.

  17. Exploring the efficacy of an educational approach of case-writing for remote learners: insights from a novice writer. International-journal

    Kenko Aoki, Chiharu Ota, Yosuke Kakisaka

    Rural and remote health　23　(4)　8527-8527　2023/10

    DOI： 10.22605/RRH8527 　

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  18. Referral odyssey plot to visualize causes of surgical delay in mesial temporal lobe epilepsy with hippocampal sclerosis. International-journal

    Kazutoshi Konomatsu, Yosuke Kakisaka, Makoto Ishida, Temma Soga, Kazushi Ukishiro, Shin-Ichiro Osawa, Kazutaka Jin, Masashi Aoki, Nobukazu Nakasato

    Epilepsy & behavior : E&B　147　109434-109434　2023/09/14

    DOI： 10.1016/j.yebeh.2023.109434 　

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    The "odyssey plot" was used to visualize referral delays in epilepsy surgery. Participants were 36 patients (19 males; 13-67 years, median 27 years) with mesial temporal lobe epilepsy with hippocampal sclerosis (HS) who underwent resection surgery. The "referral odyssey plot" included five clinical episodes: seizure onset (T1), first visits to a non-epileptologist (T2) and to an epileptologist (T3), first admission to our epilepsy monitoring unit (EMU) (T4), and resection surgery (T5). For each patient, we identified the first seizure type: the physician who first diagnosed focal aware seizure (FAS), focal impaired awareness seizure (FIAS), focal to bilateral tonic-clonic seizure (FBTCS), and radiologically suspected HS. Within the overall delay (T1-T5, median 18 years; interquartile range [IQR] 14), non-epileptologist's delay (T2-T3, 11.5 years; IQR 12.25) was far (p < 0.0001) longer than patient's (T1-T2, 0 year; IQR 2.25), epileptologist's (T3-T4, 1 year; IQR 4), or after-EMU delay (T4-T5, 1 year; IQR 1). FAS onset cases had significantly longer T1-T2 (N = 5, median 7 years; IQR 6) than FIAS (N = 22, 0 year; IQR 1, p < 0.005) or FBTCS onset cases (N = 9, 0 year; IQR 0, p < 0.001). FAS was correctly diagnosed first by non-epileptologists in 17.9%, by out-patient epileptologists in 35.7%, and at the EMU in 46.4%. FIAS was correctly diagnosed first by non-epileptologists in 94.4% and by out-patient epileptologists in 5.6%. Non-epileptologists diagnosed FBTCS in all cases. HS was diagnosed by non-epileptologists in 13.9%, by out-patient epileptologists in 47.2%, and at the EMU in 38.9%. Early referral to epileptologists is most critical for early surgery. Early utilization of the EMU is highly recommended because FAS is often overlooked by outpatient epileptologists. The odyssey plot will be useful to improve the healthcare system for other types of epilepsy.

  19. Temporomandibular joint dislocation during epileptic seizures in the epilepsy monitoring unit: A case report

    Takafumi Kubota, Kazutaka Jin, Keigo Honoki, Temma Soga, Kazushi Ukishiro, Yosuke Kakisaka, Masashi Aoki, Nobukazu Nakasato

    Epileptic Disorders　2023/09

    Publisher: Wiley

    DOI： 10.1002/epd2.20158 　

    ISSN： 1294-9361

    eISSN： 1950-6945

  20. Dynamic electro‐clinical changes corresponding to immediate recovery after glucose administration from insulinoma‐induced hypoglycemia: report of two cases

    Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Kazushi Ukishiro, Ayumi Sakata, Takafumi Shimogawa, Takato Morioka, Takafumi Kubota, Temma Soga, Masashi Aoki, Nobukazu Nakasato

    Epileptic Disorders　2023/08/26

    Publisher: Wiley

    DOI： 10.1002/epd2.20155 　

    ISSN： 1294-9361

    eISSN： 1950-6945

  21. Combination of Lectures for Case-report Writing and Advances in Internet Technology May Be a Possible Solution for "Encouraging Students and Trainees to Write".

    Yosuke Kakisaka, Chiharu Ota, Jun-Ichi Kameoka

    JMA journal　6　(3)　360-361　2023/07/14

    DOI： 10.31662/jmaj.2023-0045 　

  22. 側頭葉てんかん患者のセルフスティグマの予測因子

    小川 舞美, 藤川 真由, 田崎 勝也, 柿坂 庸介, 神 一敬, 中里 信和

    The Japanese Journal of Rehabilitation Medicine　60　(特別号)　4-6　2023/05

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  23. Patients with bear-associated injuries may vary between countries. International-journal

    Kenko Aoki, Ayako Watanabe, Yosuke Kakisaka, Motoyasu Nakamura, Yasuo Fujita, Kenji Dohi

    Injury　2023/04/15

    DOI： 10.1016/j.injury.2023.04.019 　

  24. Case study of a migraine patient with multiple extracephalic symptoms including melena due to telangiectasia of the sigmoid colon : a possible new migraine-associated symptom.

    Yosuke Kakisaka, Hiroshi Ishii

    The journal of medical investigation : JMI　70　(1.2)　298-300　2023

    DOI： 10.2152/jmi.70.298 　

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    Migraine is a chronic neurological disorder characterized by headaches and extracephalic symptoms. We report a 73-year-old male patient with a history of migraines as well as several other chronic conditions including abdominal pain accompanied by nausea and vomiting, pain and ecchymosis of the limbs, dysmetropsia, syncope, and melena due to telangiectasia of the sigmoid colon. After a thorough evaluation of the migraine condition, we hypothesized that the patient's melena due to telangiectasia of the sigmoid colon might in fact be a migraine-related phenomenon. In this report, we discuss a possible mechanism for melena due to telangiectasia in migraine patients, as well as "tips" for identifying subtle and/or unreported clinical features of migraine conditions. J. Med. Invest. 70 : 298-300, February, 2023.

  25. Web会議システムを用いた遠隔外来による迷走神経刺激療法の外来刺激調整 Peer-reviewed

    古知 龍三郎, 大沢 伸一郎, 成田 徳雄, 柴田 憲一, 森田 隆弘, 村上 謙介, 柿坂庸介, 中里 信和, 冨永 悌二

    てんかん研究　41　11-16　2023

  26. Distribution of postictal slowing has an additional yield to interictal epileptiform discharge in predicting surgical outcomes in temporal lobe epilepsy. International-journal

    Sally Shaaban, Yosuke Kakisaka, Tamer Belal, Kazutaka Jin, Shin-Ichiro Osawa, Teiji Tominaga, Ibrahim Elmenshawi, Nobukazu Nakasato

    Epilepsia open　7　(4)　802-809　2022/10/12

    DOI： 10.1002/epi4.12660 　

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    OBJECTIVE: To investigate whether the slowing of bilateral postictal scalp electroencephalography (EEG) after focal impaired awareness seizures is associated with poor seizure outcomes after temporal lobe epilepsy (TLE) surgery. METHODS: This retrospective cohort study was conducted in the Department of Epileptology, Tohoku University Hospital from 2010 to 2020. The study included 42 patients with TLE who underwent a detailed presurgical evaluation and sequential resective surgery for the unilateral probable epileptogenic temporal lobe with one year or more of follow-up. We reviewed the interictal epileptiform distribution and those of the ictal and postictal epochs of the first focal impaired awareness seizure recorded in presurgical scalp EEG. We classified patients either with postoperative seizure-free status (Engel I) as group A or those with seizure persistence (Engel II-IV) as group B. RESULTS: Of 42 patients, 29 (69 %) were classified into group A. Compared with group B, group A had a lower number of bilateral postictal polymorphic delta activity (PPDA) (10.3%: 61.5%) and bilateral interictal epileptiform discharges (IEDs) (13.8%: 69.2%) (p=0.003, p=0.001, respectively). A combined analysis of bilateral PPDA and IEDs per individual patient showed significantly more frequent seizure persistence after surgery (p <0.0001) than a single analysis of bilateral IEDs or PPDA alone (p=0.001). The regression analysis revealed that bilaterally distributed PPDA or IEDs had 13.50 or 13.72 times higher odds of persisting seizures within 1 year of surgery (95% confidence interval: 1.90-95.88; 2.12-88.87, respectively) (p=0.009, 0.006). SIGNIFICANCE: The results of this study revealed that the bilateral distribution of PPDA was associated with poor postoperative seizure outcomes in patients with TLE, as well as bilateral IEDs. Additionally, the concomitant bilateral distribution of interictal and postictal changes is a strong indicator of poor surgical outcomes.

  27. Age-Related Recovery of Daily Living Activity After 1-Stage Complete Corpus Callosotomy: A Retrospective Analysis of 41 Cases. International-journal

    Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Nobukazu Nakasato

    Neurosurgery　90　(5)　547-551　2022/02/09

    DOI： 10.1227/NEU.0000000000001871 　

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    BACKGROUND: Recovery time after corpus callosotomy (CC) is known to be longer in elderly than in younger patients. OBJECTIVE: To evaluate the relationship between patient age and recovery time of activities of daily living (ADL) after 1-stage complete CC. METHODS: This study included 41 patients (22 women; aged 13 months-34 years, median 7 years) who underwent 1-stage complete CC for medically intractable seizures with drop attacks, infantile spasms, and/or bilaterally synchronized electroencephalographic discharges between August 2009 and April 2019. The timing of restart of competence in 5 ADL categories and surgical outcomes were recorded. RESULTS: Patients (1) restarted speech at 2.2 ± 1.3 (mean ± 2 standard deviations; range 1-5) days, (2) restarted replying with their own name on request at 5.5 ± 8.6 (2-33) days, (3) restarted oral intake at 1.6 ± 1.7 (1-11) days, (5) discontinued intravenous feeding at 6.0 ± 3.0 (2-16) days, and (5) restarted ambulation or wheelchair movement at 5.8 ± 3.4 (2-10) days. Younger patients showed significantly (P < .0223) earlier recovery of ambulation or wheelchair movement, but no age difference was found in the other 4 ADL categories. Overall seizure freedom was achieved in 5 patients, excellent (>80%) seizure reduction in 11, good (50%-80%) seizure reduction in 5, and poor (<50%) seizure reduction in 20. CONCLUSION: Early ADL recovery after 1-stage complete CC is favorable in both young and adult patients. These findings, with good surgical outcomes, will encourage more positive consideration of 1-stage complete CC in both pediatric and adult patients.

  28. Writingと医療面接に力点を置いた東北医科薬科大学の医学英語教育 : 対面授業と遠隔授業の違いを含めて Peer-reviewed

    亀岡淳一, 芦田ルリ, 柿坂庸介, 野中泉, 中村豊, 大野勲

    Journal of Medical English Education　20　69-79　2021/10

  29. 開頭術後に生じた心因性非てんかん発作心理社会的アプローチが著効した1例 Peer-reviewed

    小川舞美, 大沢伸一郎, 上利 大, 柿坂庸介, 神 一敬, 冨永悌二, 中里信和

    脳神経外科速報　31　(6)　e20213106a　2021/10

  30. Acceptance of disability predicts quality of life in patients with epilepsy. International-journal

    Maimi Ogawa, Mayu Fujikawa, Kazutaka Jin, Yosuke Kakisaka, Takashi Ueno, Nobukazu Nakasato

    Epilepsy & behavior : E&B　120　107979-107979　2021/07

    DOI： 10.1016/j.yebeh.2021.107979 　

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    BACKGROUND: Acceptance of disability (AOD) is a key concept in rehabilitation psychology that enhances psychosocial adjustment of individuals with disability. However, the impact of AOD on well-being has never been examined for patients with epilepsy. The present study investigated whether AOD affects quality of life (QOL) in patients with epilepsy in the presence of other multiple aspects of epilepsy based on the biopsychosocial model. METHODS: We retrospectively reviewed 151 consecutive patients with epilepsy (77 men, aged 18-74 years) who underwent comprehensive assessment including long-term video-EEG monitoring, neuroimaging studies, and neuropsychological and psychosocial assessment in our epilepsy monitoring unit. Data were obtained from medical records and self-reported questionnaires. The outcome variable was QOL. Predictive variables included demographic characteristics, seizure-related variables (i.e., duration of epilepsy, seizure frequency, and number of antiepileptic drugs), psychological factors (i.e., AOD, depression, and self-stigma), and social factors (i.e., social support and education level). Acceptance of disability was measured by the Adaptation of Disability Scale-Revised (ADS-R), which we translated into Japanese with the original author's approval, and examined its internal consistency reliability. Data were analyzed using four hierarchical multiple regression analysis models. RESULTS: The mean ADS-R score was 80 (range 45-115). The predictors accounted for 42% of the variance in QOL (R2 = 0.45, ΔR2 = 0.42, F[8, 141] = 14.47, p = 0.00). Higher AOD (p < 0.01), higher social support (p < 0.01), and lower depression scores (p = 0.02) were found to contribute significantly to higher overall QOL. CONCLUSION: The present study revealed AOD as an important psychological concept, in addition to social support and depression as previously reported, to improve the QOL of patients with epilepsy. Acceptance of disability should be incorporated in the intervention to increase QOL of patients with epilepsy.

  31. Magnetoencephalography to confirm epileptiform discharges mimicking small sharp spikes in temporal lobe epilepsy. International-journal

    Dai Agari, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Makoto Ishida, Ryuta Kawashima, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　132　(8)　1785-1789　2021/05/08

    DOI： 10.1016/j.clinph.2021.03.049 　

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    OBJECTIVE: To determine whether magnetoencephalography (MEG) can identify epileptiform discharges mimicking small sharp spikes (SSSs) on scalp electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE). METHODS: We retrospectively reviewed simultaneous scalp EEG and MEG recordings of 83 consecutive patients with TLE and 49 with extra-TLE (ETLE). RESULTS: SSSs in scalp EEG were detected in 15 (18.1%) of 83 TLE patients compared to only two (4.1%) of 49 ETLE patients (p = 0.029). Five of the 15 TLE patients had MEG spikes with concurrent SSSs in EEG, but neither of the 2 ETLE patients. Three of these 5 TLE patients had additional interictal epileptiform discharges (IEDs) in EEG and MEG. Equivalent current dipoles (ECDs) of MEG spikes with concurrent SSSs and IEDs showed no difference in temporal lobe localization and horizontal orientation, whereas ECD moments were smaller in MEG spikes with concurrent SSSs than those with IEDs. CONCLUSIONS: SSSs were more common in TLE than in ETLE. At least some morphologically diagnosed SSSs are true but low-amplitude epileptiform discharges in TLE which can be identified with simultaneous MEG. SIGNIFICANCE: Simultaneous MEG is useful to identify epileptiform discharges mimicking SSSs in patients with TLE.

  32. てんかん領域におけるオンライン診療

    柿坂庸介, 中里信和

    カレントテラピー　39　(4)　34-37　2021/04

  33. Initial delta and delayed theta/alpha pattern in the temporal region on ictal EEG suggests purely hippocampal epileptogenicity in patients with mesial temporal lobe epilepsy. International-journal

    Izumi Itabashi, Kazutaka Jin, Shiho Sato, Hiroyoshi Suzuki, Masaki Iwasaki, Yu Kitazawa, Yosuke Kakisaka, Nobukazu Nakasato

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　132　(3)　737-743　2021/03

    DOI： 10.1016/j.clinph.2020.11.041 　

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    OBJECTIVE: To determine whether the ictal scalp EEG findings suggest purely hippocampal epileptogenicity in patients with mesial temporal lobe epilepsy (mTLE) associated with hippocampal sclerosis (HS). METHODS: Twenty-three patients with mTLE with pathologically confirmed HS were divided into 12 with epileptogenicity only in the hippocampus (HS only group) and 11 with epileptogenicity in both the hippocampus and temporal neocortex or other locations (HS plus group), based on the combination of surgical procedures, postoperative outcome, and pathological findings. Sixteen underwent selective amygdalohippocampectomy (SelAH) and 7 received anterior temporal lobectomy. Ictal scalp EEG findings of 79 focal impaired awareness seizures were compared between the HS only and HS plus groups. We focused on the 1-4 Hz rhythmic delta activity at ictal onset followed by 5-9 Hz rhythmic theta/alpha activity 10-30 s after the onset in the temporal region. RESULTS: The initial delta and delayed theta/alpha (ID-DT) pattern was observed in 8 of 12 patients in the HS only group, but in none of 11 patients in the HS plus group (p < 0.01). CONCLUSIONS: ID-DT pattern on ictal EEG suggests purely hippocampal epileptogenicity in mTLE with HS. SIGNIFICANCE: Patients with the ID-DT pattern are likely to become seizure-free after SelAH.

  34. オンライン教育のプレゼンテーションにおける残像効果のある「指マーカー機能」の有用性

    柿坂 庸介, 神 一敬, 大沢 伸一郎, 中里 信和

    日本遠隔医療学会学術大会プログラム・抄録集　24回　161-161　2021/02

    Publisher: (一社)日本遠隔医療学会

  35. Five-day observation program in adult epileptology for undergraduate medical students.

    Kakisaka Y., Jin K., Osawa S., Nakasato N.

    Epilepsia　62　(S3)　64-65　2021/01

  36. Epilepsy in Five Long-term Survivors of Pineal Region Tumors.

    Yutaro Takayama, Kazutaka Jin, Shin-Ichiro Osawa, Masaki Iwasaki, Kazushi Ukishiro, Yosuke Kakisaka, Teiji Tominaga, Tetsuya Yamamoto, Nobukazu Nakasato

    NMC case report journal　8　(1)　773-780　2021

    DOI： 10.2176/nmccrj.cr.2021-0093 　

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    Cognitive decline is a well-known chronic side effect of multidisciplinary treatment of pineal region tumors, whereas epilepsy is an under-reported chronic consequence caused by multiple potential factors including radiotherapy, surgery, or chemotherapy. Some long-term survivors have suffered drug-resistant epilepsy after treatment, which impaired the quality of life. We report five consecutive patients with drug-resistant epilepsy after combined treatment of pineal region tumor (5 men, aged 21-42 years) among 1201 epilepsy patients who underwent comprehensive evaluation in our tertiary epilepsy center from 2011 to 2018. The comprehensive epilepsy evaluation included medical interview, long-term video electroencephalography (EEG) monitoring (VEM), and magnetic resonance (MR) imaging. The patients started to have seizures at 2-22 years after initial treatment for the tumor. Four of the five patients had focal impaired awareness seizures, whereas one patient had only visual aura. All patients had EEG seizures during VEM, which confirmed the diagnosis of focal epilepsy, but three patients had no interictal epileptiform discharges (IEDs). Two patients had diagnoses of focal epilepsy arising from the left occipital region based on ictal EEG findings. Both patients had MR imaging lesion in the left occipital lobe, radiation-induced cavernoma, or surgical injury. The remaining three patients showed poor localization of epileptogenic foci based on VEM and MR imaging. Drug-resistant epilepsy after multidisciplinary treatment of pineal region tumor is characterized by focal impaired awareness seizures with poorly localized EEG onset or rare interictal spikes.

  37. オンライン教育のプレゼンテーションにおける残存効果のある「指マーカー機能」の有用性. Peer-reviewed

    柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

    日本遠隔医療学会雑誌　16　145-147　2021/01

  38. てんかん診療における遠隔外来と包括的入院精査の相補的利用. Peer-reviewed

    柿坂庸介, 大沢伸一郎, 成田徳雄, 神一敬, 冨永悌二, 中里信和

    脳神経外科速報　30　(11)　1254-1261　2020/12

  39. Normal Variants in Magnetoencephalography. International-journal Peer-reviewed

    Stefan Rampp, Yosuke Kakisaka, Sumiya Shibata, Xingtong Wu, Karl Rössler, Michael Buchfelder, Richard C Burgess

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society　37　(6)　518-536　2020/11

    DOI： 10.1097/WNP.0000000000000484 　

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    Normal variants, although not occurring frequently, may appear similar to epileptic activity. Misinterpretation may lead to false diagnoses. In the context of presurgical evaluation, normal variants may lead to mislocalizations with severe impact on the viability and success of surgical therapy. While the different variants are well known in EEG, little has been published in regard to their appearance in magnetoencephalography. Furthermore, there are some magnetoencephalography normal variants that have no counterparts in EEG. This article reviews benign epileptiform variants and provides examples in EEG and magnetoencephalography. In addition, the potential of oscillatory configurations in different frequency bands to appear as epileptic activity is discussed.

  40. Diagnostic yield of seizure recordings and neuroimaging in patients with focal epilepsy without interictal epileptiform discharges. International-journal Peer-reviewed

    Minori Suzuki, Kazutaka Jin, Yu Kitazawa, Mayu Fujikawa, Yosuke Kakisaka, Shiho Sato, Shunji Mugikura, Nobukazu Nakasato

    Epilepsy & behavior : E&B　112　107468-107468　2020/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.yebeh.2020.107468 　

    ISSN： 1525-5050

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    OBJECTIVE: Repeated routine electroencephalography (EEG) or even long-term video-EEG monitoring (VEM) does not always record interictal epileptiform discharges (IEDs) in some patients with epilepsy. The present study investigated whether focal seizures detected by VEM and focal abnormalities on neuroimaging are useful for the diagnosis of patients with focal epilepsy without IEDs. METHODS: We retrospectively reviewed 409 consecutive patients with focal epilepsy (207 men, aged 9 to 76 years) who underwent 4- or 5-day VEM, magnetic resonance imaging (MRI), and fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) for diagnosis to identify patients without IEDs. The occurrence of focal seizures during VEM and the presence of focal abnormalities on neuroimaging were investigated in those patients. The occurrence rate of seizures during VEM was investigated in patients with daily, weekly, monthly, and yearly seizure frequency based on history-taking. RESULTS: Ninety-five (23.2%) of 409 patients with focal epilepsy did not have IEDs. Fifty-five (57.9%) of the 95 patients had focal seizures during VEM. Fifty-four patients (56.8%) showed focal abnormalities compatible with seizure semiology on neuroimaging investigations. Neither seizure recordings nor neuroimaging abnormalities were seen in 16 (16.8%) of the 95 patients. The occurrence rate of seizures during VEM depended on the seizure frequency at history-taking. However, 28 (45.9%) of 61 patients with monthly and yearly seizure frequency had focal seizures during 4- or 5-day VEM with seizure induction. CONCLUSIONS: Video-EEG monitoring can detect focal seizures in patients with focal epilepsy but no IEDs. Comprehensive assessment including VEM and neuroimaging study is important for the diagnosis.

  41. Awake state-specific suppression of primary somatosensory evoked response correlated with duration of temporal lobe epilepsy. International-journal Peer-reviewed

    Makoto Ishida, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato

    Scientific reports　10　(1)　15895-15895　2020/09/28

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-020-73051-x 　

    eISSN： 2045-2322

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    Epilepsy is a network disease. The primary somatosensory cortex (S1) is usually considered to be intact, but could be subclinically disturbed based on abnormal functional connectivity in patients with temporal lobe epilepsy (TLE). We aimed to investigate if the S1 of TLE is abnormally modulated. Somatosensory evoked magnetic fields (SEFs) evoked by median nerve stimulation were recorded in each hemisphere of 15 TLE patients and 28 normal subjects. All responses were separately averaged in the awake state and light sleep using background magnetoencephalography. Latency and strength of the equivalent current dipole (ECD) was compared between the groups for the first (M1) and second peaks. Latencies showed no significant differences between the groups in either wakefulness or light sleep. ECD strengths were significantly lower in TLE patients than in controls only during wakefulness. The reduction of M1 ECD strength in the awake state is significantly correlated with duration of epilepsy. SEFs of TLE patients showed pure ECD strength reduction without latency delay. The phenomenon occurred exclusively during wakefulness, suggesting that a wakefulness-specific modulator of S1 is abnormal in TLE. Repetitive seizures may gradually insult the modulator of S1 distant from the epileptogenic network.

  42. Revisional Analysis of Electroencephalography and Magnetoencephalography Based on Comprehensive Epilepsy Conference Peer-reviewed

    Nakasato N, Kanno A, Ishida M, Osawa S, Iwasaki M, Kakisaka Y, Jin K

    Fifty Years of Magnetoencephalography.　191-197　2020/09

    Publisher: Oxford University Press

    DOI： 10.1093/oso/9780190935689.003.0013 　

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    <p>This chapter highlights the importance of the revised analysis of electroencephalography (EEG) and magnetoencephalography (MEG) spike source estimation based on comprehensive case conference discussion. It discusses two typical cases of localization-related epilepsy: case 1 as a simple situation and case 2 as a complicated situation. No “gold standard” for epileptic spike analysis in EEG or MEG has been established, so several methods must be adopted to achieve the most reasonable interpretation. However, such intense and revisional analyses may be too time-consuming in clinical settings and result in arbitrary conclusions. Therefore, the authors currently use a simple method first, that is, a single dipole model for the peak or preceding upward slope of unaveraged single spikes. In the following case conference, EEG and MEG data are reviewed with seizure semiology, anatomical magnetic resonance imaging (MRI), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). If all the findings almost agree, the clinical decision can be easily made. If not, revisional analysis of EEG/MEG is recommended using averaged spikes and principal component analysis models as well as distributed source models. In addition to EEG/MEG, the authors often order revisional analysis and additional MRI and FDG-PET studies after the conference. Even further history taking will be recommended if necessary.</p>

  43. External validation of the Epilepsy Surgery Grading Scale in a Japanese cohort of patients with epilepsy. Peer-reviewed

    Gabriel F, Kakisaka Y, Jin K, Osawa S, Iwasaki M, Tominaga T, Nakasato N

    Epileptic Disorders　23　104-110　2020/09

  44. Two males with sick sinus syndrome in a family with 0.6 kb deletions involving major domains in MECP2. International-journal Peer-reviewed

    Takehiko Inui, Kazuhiro Iwama, Takuya Miyabayashi, Ryo Sato, Yukimune Okubo, Wakaba Endo, Noriko Togashi, Yosuke Kakisaka, Atsuo Kikuchi, Takeshi Mizuguchi, Shigeo Kure, Naomichi Matsumoto, Kazuhiro Haginoya

    European journal of medical genetics　63　(3)　103769-103769　2020/03

    DOI： 10.1016/j.ejmg.2019.103769 　

    ISSN： 1769-7212

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    Mutations in methyl-CpG-binding protein 2 (MECP2) in males can lead to various phenotypes, ranging from neonatal encephalopathy to intellectual disability. In this study, using Nord's method of next-generation sequencing in three siblings, we identified a 0.6 kb deletion involving the transcriptional repression domain (TRD). Two males and one female had intellectual disability and apnea, but none met the criteria of Rett syndrome. Both males had sick sinus syndrome and severe tracheomalacia that resulted in early death. The mother, with skewed X-inactivation, had no symptoms. Therefore, this mutation is pathological for both males and females, resulting in sick sinus syndrome and severe tracheomalacia with strong reproducibility in males. Deletions involving major domains in MECP2 can result in a severe phenotype, and deletion of the TRD domain can cause severe autonomic nervous system dysregulation in males in these cases.

  45. Apparently diffuse epileptic abnormalities caused by a small cavernous malformation: a surgical case report Peer-reviewed

    Ninomiya A, Iwasaki M, Kakisaka Y, Jin K, Nakasato N, Tominaga T

    Epilepsy & Seizure　10　(1)　107-113　2018/12

  46. [18F]fluorodeoxyglucose-positron emission tomography study of genetically confirmed patients with Dravet syndrome Peer-reviewed

    Kazuhiro Haginoya, Noriko Togashi, Tomohiro Kaneta, Naomi Hino-Fukuyo, Mamiko Ishitobi, Yosuke Kakisaka, Mitsugu Uematsu, Takehiko Inui, Yukimune Okubo, Ryo Sato, Takuya Miyabayashi, Akira Arai, Ikuo Ogiwara, Emi Mazaki, Kazuhiro Yamakawa, Kazuhie Iinuma, Shigeo Kure

    Epilepsy Research　147　9-14　2018/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.eplepsyres.2018.08.008 　

    ISSN： 0920-1211

  47. Information and communication technology in epilepsy care

    BioClinica　33　(11)　1032-1036　2018/10

  48. 焦点性てんかん患者における発作後全般性脳波抑制とノンレム睡眠時の心拍変動異常との関連

    坂本 美佳, 神 一敬, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　36　(2)　507-507　2018/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  49. Teleconference-based education of epileptic seizure semiology. International-journal Peer-reviewed

    Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Yu Kitazawa, Nobukazu Nakasato

    Epilepsy research　145　73-76　2018/09

    DOI： 10.1016/j.eplepsyres.2018.06.007 　

    ISSN： 0920-1211

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    BACKGROUND: To evaluate whether a teleconference-based lecture provides similar understanding of seizure semiology to a face-to-face lecture for physicians. METHODS: Subjects were 66 physicians consisting of adult and pediatric neurologists, neurosurgeons, psychiatrists, and general practitioners. All attended the 30-minute lecture to introduce various types of seizure semiology using video-clips by one of the authors (Yo.K.) and then joined the comprehensive case conference which discussed three cases in 1.5 h. Group A received the lecture and conference using a teleconference system (N = 43) and Group B attended in person (N = 23) for geographical reasons. After the conference, 32 subjects (23 in Group A and nine in Group B) scored their own post-lecture understanding of seizure semiology using the four-point Likert scale from 1 (not at all) to 4 (very well) as well as the estimated pre-lecture score. Data was analyzed to assess whether their understanding was improved after the lecture. RESULTS: No significant difference was found in improvement of understanding after the lecture between Group A (43%) and Group B (22%; p = 0.42). Pre-lecture score of subjects with improved understanding was significantly lower (2.3 +/- 0.2) than those without improvement (3.7 +/- 0.1) (p < 0.05). SIGNIFICANCE: Teleconference-based lectures can be a useful tool to educate seizure semiology for physicians, especially at the inexperienced level, by overcoming geographical limitations.

  50. Predictive factors of higher drug load for seizure freedom in idiopathic generalized epilepsy: Comparison between juvenile myoclonic epilepsy and other types. International-journal Peer-reviewed

    Yu Kitazawa, Kazutaka Jin, Yosuke Kakisaka, Mayu Fujikawa, Fumiaki Tanaka, Nobukazu Nakasato

    Epilepsy research　144　20-24　2018/08

    DOI： 10.1016/j.eplepsyres.2018.04.009 　

    ISSN： 0920-1211

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    PURPOSE: Predictive factors of higher drug load for seizure freedom were investigated in idiopathic generalized epilepsy (IGE), focusing on the difference between juvenile myoclonic epilepsy (JME) and other types of IGE (non-JME IGE). METHODS: Twelve patients with JME and 12 patients with non-JME IGE, who achieved seizure freedom for 1 year or longer with appropriate antiepileptic drugs (AEDs) after video electroencephalography monitoring, were reviewed retrospectively. The sum of prescribed daily dose/defined daily dose ratio of all prescribed AEDs at the final visit was defined as total AED load. Patients requiring total AED load >1 were classified into the higher AED load group. Clinical background and the presence of interictal focal epileptiform abnormalities (FEAs) were compared between the higher and lower AED load groups. RESULTS: Higher AED load group of patients with JME had interictal FEAs and family history of epilepsy more frequently than the lower AED load group (p = 0.03 and p = 0.03). Similar comparison of patients with non-JME IGE showed no significant differences. CONCLUSIONS: The presence of interictal FEAs and a family history of epilepsy are significantly associated variables for higher AED load for seizure freedom in patients with JME, but not in patients with non-JME IGE.

  51. Assessment of the Utility of Ictal Magnetoencephalography in the Localization of the Epileptic Seizure Onset Zone. Peer-reviewed

    Alkawadri R, Burgess RC, Kakisaka Y, Mosher JC, Alexopoulos AV

    JAMA neurology　2018/06

    DOI： 10.1001/jamaneurol.2018.1430 　

    ISSN： 2168-6149

  52. Stressful medical explanation may cause syncope in patients with emotion-triggered neurocardiogenic syncope. International-journal Peer-reviewed

    Kazuhiro Kato, Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Miki Nakamura, Natsumi Suzuki, Masateru Kondo, Koji Fukuda, Hiroaki Shimokawa, Nobukazu Nakasato

    Pacing and clinical electrophysiology : PACE　41　(1)　96-98　2018/01

    DOI： 10.1111/pace.13199 　

    ISSN： 0147-8389

  53. MEG May Reveal Hidden Population of Spikes in Epilepsy With Porencephalic Cyst/Encephalomalacia Peer-reviewed

    Yosuke Kakisaka, Zhong I. Wang, Sumiya Shibata, Yoko Takahashi, John C. Mosher, Andreas V. Alexopoulos, Richard C. Burgess

    JOURNAL OF CLINICAL NEUROPHYSIOLOGY　34　(6)　546-549　2017/11

    DOI： 10.1097/WNP.0000000000000362 　

    ISSN： 0736-0258

    eISSN： 1537-1603

  54. 睡眠段階に着目したてんかん患者の心拍変動解析

    坂本 美佳, 神 一敬, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　35　(2)　547-547　2017/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  55. 発作起始の睡眠段階と時間帯に着目した強直間代発作の鑑別診断

    新村 彩香, 神 一敬, 板橋 泉, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　35　(2)　604-604　2017/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  56. 神経救急患者のけいれん性疾患の診断予測に与える乳酸値測定の有用性 連続661症例の検討から

    大沢 伸一郎, 藤田 健亮, 神 一敬, 柿坂 庸介, 川村 強, 今 明秀, 久志本 成樹, 中里 信和, 冨永 悌二

    てんかん研究　35　(2)　508-508　2017/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  57. Reversible brain atrophy in glutaric aciduria type 1 Peer-reviewed

    Yurika Numata-Uematsu, Osamu Sakamoto, Yosuke Kakisaka, Yukimune Okubo, Yoshitsugu Oikawa, Natsuko Arai-Ichinoi, Shigeo Kure, Mitsugu Uematsu

    BRAIN & DEVELOPMENT　39　(6)　532-535　2017/06

    DOI： 10.1016/j.braindev.2017.01.003 　

    ISSN： 0387-7604

    eISSN： 1872-7131

  58. A novel mutation in the proteolytic domain of LONP1 causes atypical CODAS syndrome Peer-reviewed

    Takehiko Inui, Mai Anzai, Yusuke Takezawa, Wakaba Endo, Yosuke Kakisaka, Atsuo Kikuchi, Akira Onuma, Shigeo Kure, Ichizo Nishino, Chihiro Ohba, Hirotomo Saitsu, Naomichi Matsumoto, Kazuhiro Haginoya

    JOURNAL OF HUMAN GENETICS　62　(6)　653-655　2017/06

    DOI： 10.1038/jhg.2017.11 　

    ISSN： 1434-5161

    eISSN： 1435-232X

  59. 成人てんかん患者における病状説明と心理社会的要因の関連

    Ogaw M, Fujikawa M, Iwaki H, Kitazawa Y, Kakisaka Y, Jin K, Nakasato N, Ueno T

    東北大学大学院教育学研究科臨床心理相談室紀要　15　25-38　2017/03/17

  60. [Ictal Speech Manifesting as Sleep Talking: A Case Report]. Peer-reviewed

    Takehiro Suzuki, Yosuke Kakisaka, Yu Kitazawa, Kazutaka Jin, Shiho Sato, Masaki Iwasaki, Mayu Fujikawa, Yoshiyuki Nishio, Akitake Kanno, Nobukazu Nakasato

    Brain and nerve = Shinkei kenkyu no shinpo　69　(2)　167-171　2017/02

    DOI： 10.11477/mf.1416200657 　

    ISSN： 1881-6096

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    We present a 28-year-old female patient whose epilepsy started at the age of 19. MRI showed right perisylvian polymicrogyria. She exhibited various seizure symptoms, such as somatosensory aura involving the left leg, dyscognitive seizures, and amnesic seizures. Her mother indicated that the patient sometimes had "sleep talking", which was associated with presence of epileptic seizures of the next day. Long-term video electroencephalography (EEG) revealed that her episodes of "sleep talking" were epileptic events, specifically ictal speech, originating in the right hemisphere. The present case demonstrates the importance of considering "sleep talk" as an epileptic symptom. Careful history taking is fundamental to carry patients with possibly pathological "sleep talk" to the long-term video EEG, which will contribute correct diagnosis and treatment. (Received August 16, 2016; Accepted September 9, 2016; Published February 1, 2017).

  61. Variety of symptoms associated with migraine, a migraine variant and idiopathic stabbing headache.

    Kakisaka Y, Fujikawa M

    Brain Dev　39　(S3)　365-365　2017

  62. Establishing a structured program for case writing in pediatric neurology medical education: A preliminary study.

    Kakisaka Y, Fujikawa M, Hino-Fukuyo N, Ishii S

    Brain Dev　39　(S3)　364-364　2017

  63. Differences in sleep architecture between left and right temporal lobe epilepsy Peer-reviewed

    Miki Nakamura, Kazutaka Jin, Kazuhiro Kato, Hisashi Itabashi, Masaki Iwasaki, Yosuke Kakisaka, Nobukazu Nakasato

    NEUROLOGICAL SCIENCES　38　(1)　189-192　2017/01

    DOI： 10.1007/s10072-016-2731-6 　

    ISSN： 1590-1874

    eISSN： 1590-3478

  64. Levetiracetam improves symptoms of multiple chemical sensitivity: Case report. Peer-reviewed

    Yosuke Kakisaka, Kazutaka Jin, Mayu Fujikawa, Yu Kitazawa, Kazuhiro Kato, Nobukazu Nakasato

    The journal of medical investigation : JMI　64　(3.4)　296-298　2017

    DOI： 10.2152/jmi.64.296 　

    ISSN： 1343-1420

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    Multiple chemical sensitivity (MCS) is a disorder of unknown etiology with no effective treatment. Many clinicians accept that a diagnosis of somatic symptoms disorder (SSD) is an appropriate diagnostic category for MCS. We found that administration of levetiracetam improved recurrent symptoms of MCS in a patient. A 23-year-old female presented with recurrent multiple symptoms of musculoskeletal, airway or mucous membrane, heart/chest-related, gastrointestinal, cognitive, affective, neuromuscular, head-related, and skin-related induced by exposure to diesel or gas engine exhaust, tobacco smoke, insecticide, gasoline, paint or paint thinner, cleaning products, fragrances, tar or asphalt, nail polish or hairspray, and new furnishings. Gastrointestinal, cognitive, and skin-related symptoms were precipitated by some food additives. She suffered partial seizures from the age of 17 years, and was diagnosed with right parietal lobe epilepsy. Administration of levetiracetam (250 mg/day) eliminated her MCS symptoms. Levetiracetam reduces the release of presynaptic neurotransmitter including glutamate by binding to presynaptic vesicle protein. A recent study established the presence of glutamatergic overactivation in somatization disorder, a form of SSD. Our case may indicate that a subset of patients with SSD have glutamatergic overactivation, which levetiracetam can normalize. J. Med. Invest. 64: 296-298, August, 2017.

  65. Correlating magnetoencephalography to stereo-electroencephalography in patients undergoing epilepsy surgery Peer-reviewed

    Hiroatsu Murakami, Zhong I. Wang, Ahmad Marashly, Balu Krishnan, Richard A. Prayson, Yosuke Kakisaka, John C. Mosher, Juan Bulacio, Jorge A. Gonzalez-Martinez, William E. Bingaman, Imad M. Najm, Richard C. Burgess, Andreas V. Alexopoulos

    BRAIN　139　(11)　2935-2947　2016/11

    DOI： 10.1093/brain/aww215 　

    ISSN： 0006-8950

    eISSN： 1460-2156

  66. 特発性全般てんかんと前頭葉てんかんの鑑別における概日リズムの重要性

    新村 彩香, 板橋 泉, 神 一敬, 北澤 悠, 柿坂 庸介, 中里 信和

    臨床神経生理学　44　(5)　460-460　2016/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  67. Acute encephalitis with refractory, repetitive partial seizures: Pathological findings and a new therapeutic approach using tacrolimus Peer-reviewed

    Yuko Sato, Yurika Numata-Uematsu, Mitsugu Uematsu, Atsuo Kikuchi, Tojo Nakayama, Yosuke Kakisaka, Tomoko Kobayashi, Naomi Hino-Fukuyo, Hiroyoshi Suzuki, Yukitoshi Takahashi, Yoshiaki Saito, Naoyuki Tanuma, Masaharu Hayashi, Masaki Iwasaki, Kazuhiro Haginoya, Shigeo Kure

    BRAIN & DEVELOPMENT　38　(8)　772-776　2016/09

    DOI： 10.1016/j.braindev.2016.02.006 　

    ISSN： 0387-7604

    eISSN： 1872-7131

  68. A single tight MEG cluster may only represent a fragment of type I FCD Peer-reviewed

    Riem El Tahry, Z. Irene Wang, Yosuke Kakisaka, Hiroatsu Murakami, Sumiya Shibata, Balu Krishnan, Prakash Kotagal, Andreas Alexopoulos, Richard C. Burgess

    CLINICAL NEUROPHYSIOLOGY　127　(7)　2570-2572　2016/07

    DOI： 10.1016/j.clinph.2016.04.007 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  69. Epilepsy case with focal cerebral herniation into the sigmoid sinus Peer-reviewed

    Yosuke Kakisaka, Shiho Sato, Masaru Takayanagi, Nobukazu Nakasato

    NEUROLOGICAL SCIENCES　37　(3)　487-488　2016/03

    DOI： 10.1007/s10072-015-2430-8 　

    ISSN： 1590-1874

    eISSN： 1590-3478

  70. A case of 3p deletion syndrome associated with cerebellar hemangioblastoma Peer-reviewed

    Sato Suzuki-Muromoto, Naomi Hino-Fukuyo, Kazuhiro Haginoya, Atsuo Kikuchi, Hiroki Sato, Yuko Sato, Tojo Nakayama, Yuki Kubota, Yosuke Kakisaka, Mitsugu Uematsu, Toshihiro Kumabe, Shigeo Kure

    BRAIN & DEVELOPMENT　38　(2)　257-260　2016/02

    DOI： 10.1016/j.braindev.2015.07.005 　

    ISSN： 0387-7604

    eISSN： 1872-7131

  71. The efficacy of lamotrigine for atypical absence status epilepticus in a case of perioral myoclonia with absence

    Yusuke Takezawa, Yosuke Kakisaka, Keisuke Wakusawa, Mamiko Ishitobi, Naomi Hino-Fukuyo, Takehiko Inui, Wakaba Endo, Mai Anzai, Nobukazu Nakasato, Kazuhiro Haginoya

    Epilepsy and Seizure　8　(1)　1-8　2016

    Publisher: Japan Epilepsy Society

    DOI： 10.3805/eands.8.1 　

    ISSN： 1882-5567

    eISSN： 1882-5567

  72. Structured Didactic Education Program for Writing Case Reports Can Motivate Medical Students Peer-reviewed

    Kakisaka Y, Fujikawa M, Gaillard S

    Int J Med Student　4　131-132　2016

  73. Writing Case Reports: Teaching and Tuition Techniques, and the Improvement of Clinical Diagnostic Reasoning. Peer-reviewed

    Kakisaka Y, Fujikawa M, Gaillard S

    Int J Med Student　4　87-89　2016

  74. High frequency oscillations are less frequent but more specific to epileptogenicity during rapid eye movement sleep Peer-reviewed

    Rie Sakuraba, Masaki Iwasaki, Eiichi Okumura, Kazutaka Jin, Yosuke Kakisaka, Kazuhiro Kato, Teiji Tominaga, Nobukazu Nakasato

    CLINICAL NEUROPHYSIOLOGY　127　(1)　179-186　2016/01

    DOI： 10.1016/j.clinph.2015.05.019 　

    ISSN： 1388-2457

    eISSN： 1872-8952

  75. Fantastic confabulation in right frontal lobe epilepsy. International-journal Peer-reviewed

    Mayu Fujikawa, Yoshiyuki Nishio, Yosuke Kakisaka, Nanayo Ogawa, Masaki Iwasaki, Nobukazu Nakasato

    Epilepsy & behavior case reports　6　55-7　2016

    DOI： 10.1016/j.ebcr.2016.08.003 　

    More details Close

    BACKGROUND: Interictal behavioral symptoms in frontal lobe epilepsy (FLE) are variable and often difficult to discriminate from other localization-related epilepsies. METHODS AND RESULTS: We report two female patients with right FLE who exhibited fantastic confabulations. One of the patients had a 14-year history of hypermotor seizures, and the other had a 10-year history of dyscognitive seizures with automatism. Their fantastic confabulations arose in the context of moderate-to-severe cognitive impairment and of a variety of behavioral abnormalities, including emotional withdrawal and compulsive behaviors. CONCLUSION: Fantastic confabulations are rare but may be a relatively specific behavioral marker for FLE-associated psychosis.

  76. 治療抵抗性若年ミオクロニーてんかんにおける焦点性脳波異常

    北澤 悠, 神 一敬, 加藤 量広, 柿坂 庸介, 藤川 真由, 岩崎 真樹, 田中 章景, 中里 信和

    臨床神経生理学　43　(5)　459-459　2015/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  77. Clinical features and long-term outcome of a group of Japanese children with inflammatory central nervous system disorders and seropositivity to myelin-oligodendrocyte glycoprotein antibodies Peer-reviewed

    Naomi Hino-Fukuyo, Kazuhiro Haginoya, Ichiro Nakashima, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Tatsuro Misu, Kazuo Fujihara, Mieko Hirose, Yosuke Kakisaka, Mitsugu Uematsu, Tomoko Kobayashi, Shigeo Kure

    BRAIN & DEVELOPMENT　37　(9)　849-852　2015/10

    DOI： 10.1016/j.braindev.2015.02.006 　

    ISSN： 0387-7604

    eISSN： 1872-7131

  78. 左手のtwitchingを呈したepilepsia partialis continuaにおいて脳波脳磁図所見に乖離がみられた一例

    柿坂 庸介, 岩崎 真樹, 神 一敬, 北澤 悠, 藤川 真由, 中里 信和, So Norman

    てんかん研究　33　(2)　435-435　2015/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  79. 睡眠・覚醒リズム、概日リズムに注目した強直間代発作の鑑別

    新村 彩香, 板橋 泉, 神 一敬, 岩崎 真樹, 北澤 悠, 柿坂 庸介, 中里 信和

    てんかん研究　33　(2)　529-529　2015/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  80. 側頭葉てんかんの脳画像病変に対応した特徴的発作時脳波所見

    板橋 泉, 神 一敬, 佐藤 志帆, 岩崎 真樹, 北澤 悠, 柿坂 庸介, 鈴木 博義, 中里 信和

    てんかん研究　33　(2)　593-593　2015/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  81. Lennox-Gastaut症候群を呈した視床下部過誤腫の一例

    渡辺 靖章, 神 一敬, 高橋 健太, 柿坂 庸介, 北澤 悠, 藤川 真由, 中里 信和, 加藤 量広, 青木 正志, 岩崎 真樹

    臨床神経学　55　(7)　510-510　2015/07

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  82. バルプロ酸・ラモトリギン・レベチラセタムの3剤併用で発作消失に至った難治性若年ミオクロニーてんかんの3例

    北澤 悠, 神 一敬, 柿坂 庸介, 藤川 真由, 中里 信和, 加藤 量広, 岩崎 真樹, 田中 章景

    臨床神経学　55　(7)　510-510　2015/07

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  83. NREM睡眠時にのみ局所性発作起始を呈した側頭・頭頂・後頭葉てんかん患者3例

    板橋 泉, 神 一敬, 岩崎 真樹, 北澤 悠, 加藤 量広, 柿坂 庸介, 中里 信和

    日本睡眠学会定期学術集会プログラム・抄録集　40回　239-239　2015/07

    Publisher: (一社)日本睡眠学会

  84. REM睡眠関連発作が記録された側頭葉外てんかん患者3例

    神 一敬, 中村 美輝, 板橋 泉, 加藤 量広, 北澤 悠, 柿坂 庸介, 岩崎 真樹, 中里 信和

    日本睡眠学会定期学術集会プログラム・抄録集　40回　240-240　2015/07

    Publisher: (一社)日本睡眠学会

  85. 1-A-D-26. Pre-operative magnetoencephalographic spike localization in patients with surgically-cured epilepsy Invited

    Makoto Ishida, Masaki Iwasaki, Akitake Kanno, Kazutaka Jin, Yosuke Kakisaka, Kazuhiro Kato, Ryuta Kawashima, Nobukazu Nakasato

    Clinical Neurophysiology　126　(6)　e57-e57　2015/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.clinph.2015.02.029 　

    ISSN： 1388-2457

  86. Genomic analysis identifies candidate pathogenic variants in 9 of 18 patients with unexplained West syndrome. International-journal Peer-reviewed

    Naomi Hino-Fukuyo, Atsuo Kikuchi, Natsuko Arai-Ichinoi, Tetsuya Niihori, Ryo Sato, Tasuku Suzuki, Hiroki Kudo, Yuko Sato, Tojo Nakayama, Yosuke Kakisaka, Yuki Kubota, Tomoko Kobayashi, Ryo Funayama, Keiko Nakayama, Mitsugu Uematsu, Yoko Aoki, Kazuhiro Haginoya, Shigeo Kure

    Human genetics　134　(6)　649-58　2015/06

    DOI： 10.1007/s00439-015-1553-6 　

    ISSN： 0340-6717

    More details Close

    West syndrome, which is narrowly defined as infantile spasms that occur in clusters and hypsarrhythmia on EEG, is the most common early-onset epileptic encephalopathy (EOEE). Patients with West syndrome may have clear etiologies, including perinatal events, infections, gross chromosomal abnormalities, or cases followed by other EOEEs. However, the genetic etiology of most cases of West syndrome remains unexplained. DNA from 18 patients with unexplained West syndrome was subjected to microarray-based comparative genomic hybridization (array CGH), followed by trio-based whole-exome sequencing in 14 unsolved families. We identified candidate pathogenic variants in 50% of the patients (n = 9/18). The array CGH revealed candidate pathogenic copy number variations in four cases (22%, 4/18), including an Xq28 duplication, a 16p11.2 deletion, a 16p13.1 deletion and a 19p13.2 deletion disrupting CACNA1A. Whole-exome sequencing identified candidate mutations in known epilepsy genes in five cases (36%, 5/14). Three candidate de novo mutations were identified in three cases, with two mutations occurring in two new candidate genes (NR2F1 and CACNA2D1) (21%, 3/14). Hemizygous candidate mutations in ALG13 and BRWD3 were identified in the other two cases (14%, 2/14). Evaluating a panel of 67 known EOEE genes failed to identify significant mutations. Despite the heterogeneity of unexplained West syndrome, the combination of array CGH and whole-exome sequencing is an effective means of evaluating the genetic background in unexplained West syndrome. We provide additional evidence for NR2F1 as a causative gene and for CACNA2D1 and BRWD3 as candidate genes for West syndrome.

  87. Obsessive-compulsive behavior induced by levetiracetam. International-journal Peer-reviewed

    Mayu Fujikawa, Yuri Kishimoto, Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Nobukazu Nakasato

    Journal of child neurology　30　(7)　942-4　2015/06

    DOI： 10.1177/0883073814541471 　

    ISSN： 0883-0738

    More details Close

    A novel antiepileptic drug, levetiracetam, has been reported to cause several psychiatric adverse effects in spite of its effectiveness on epilepsy. However, a possible relationship between levetiracetam and obsessive-compulsive behavior has only been reported in a few studies with adult epilepsy patients. We treated a pediatric patient with epilepsy without past or family history of psychiatric disorder. Levetiracetam was started to control generalized tonic-clonic seizure. Two months after initiation of levetiracetam with favorable seizure control, she started to show an obsessive-compulsive behavior such as repetitive checking of her back, pants, and chair. Based on the course of its appearance, levetiracetam administration was identified as a possible cause. After termination of levetiracetam, her obsessive-compulsive behavior completely disappeared with reappearance of seizures. This case provides clear evidence that levetiracetam may cause obsessive-compulsive behavior even in a pediatric epilepsy patient without psychiatric background, possibly mediated by modulation of the glutamate system by levetiracetam.

  88. Glabellar ecchymosis and headache: Variations of pain-associated ecchymosis. International-journal Peer-reviewed

    Yosuke Kakisaka, Mayu Fujikawa, Naomi Hino-Fukuyo

    Psychiatry and clinical neurosciences　69　(6)　385-385　2015/06

    DOI： 10.1111/pcn.12266 　

    ISSN： 1323-1316

  89. [A case of focal epilepsy manifesting multiple psychiatric auras]. Peer-reviewed

    Michinori Ezura, Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Mayu Fujikawa, Masashi Aoki, Nobukazu Nakasato

    Brain and nerve = Shinkei kenkyu no shinpo　67　(1)　105-9　2015/01

    DOI： 10.11477/mf.1416200093 　

    ISSN： 1881-6096

    More details Close

    We present a case of epilepsy with multiple types of focal seizures that were misdiagnosed as psychiatric disorders. A 20-year-old female patient presented with a variety of episodes, including loss of consciousness, deja vu, fear, delusion of possession, violent movements, and generalized convulsions. Each of these symptoms appeared in a stereotypic manner. She was initially diagnosed with a psychiatric disorder and treated with psychoactive medications, which had no effect. Long-term video electroencephalography revealed that her episodes of violent movement with impaired consciousness and secondarily generalized seizure were epileptic events originating in the right hemisphere. High-field brain magnetic resonance imaging for detecting subtle lesions revealed bilateral lesions from periventricular nodular heterotopia. Her final diagnosis was right hemispheric focal epilepsy. Carbamazepine administration was started, which successfully controlled all seizures. The present case demonstrates the pitfall of diagnosing focal epilepsy when it presents with multiple types of psychiatric aura. Epilepsy should thus be included in differential diagnoses, considering the stereotypic nature of symptoms, to avoid misdiagnosis.

  90. Unilateral Phrenic Nerve Plasy: A Rare Manifestation of Vincristine Neurotoxicity: Correspondence Peer-reviewed

    Kunihiko Moriya, Yosuke Kakisaka, Masaei Onuma, Yoji Sasahara, Shigeo Kure

    INDIAN JOURNAL OF PEDIATRICS　81　(12)　1429-1429　2014/12

    DOI： 10.1007/s12098-014-1394-7 　

    ISSN： 0019-5456

    eISSN： 0973-7693

  91. The correlation of magnetoencephalography to intracranial EEG in localizing the epileptogenic zone: A study of the surgical resection outcome Peer-reviewed

    Salah Almubarak, Andreas Alexopoulos, Felix Von-Podewils, Z. Irene Wang, Yosuke Kakisaka, John C. Mosher, Juan Bulacio, Jorge Gonzalez-Martinez, Williams Bingaman, Richard C. Burgess

    EPILEPSY RESEARCH　108　(9)　1581-1590　2014/11

    DOI： 10.1016/j.eplepsyres.2014.08.016 　

    ISSN： 0920-1211

    eISSN： 1872-6844

  92. Correspondence on "Clinical Characterization of Gastroenteritis-Related Seizures in Children: Impact of Fever and Serum Sodium Levels" Peer-reviewed

    Yosuke Kakisaka, Atsuo Kikuchi, Naomi Hino-Fukuyo, Mitsugu Uematsu, Shigeo Kure

    JOURNAL OF CHILD NEUROLOGY　29　(11)　1578-1579　2014/11

    DOI： 10.1177/0883073813497428 　

    ISSN： 0883-0738

    eISSN： 1708-8283

  93. 長時間ビデオ脳波モニタリングでsubclinical rhythmic electroencephalographic discharges of adultsを認めた高齢てんかん患者3例

    横田 恵理, 櫻庭 理絵, 神 一敬, 北澤 悠, 加藤 量広, 柿坂 庸介, 岩崎 真樹, 中里 信和

    臨床神経生理学　42　(5)　352-352　2014/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  94. 側頭葉てんかんの発作時脳波と脳画像所見

    板橋 泉, 神 一敬, 岩崎 真樹, 北澤 悠, 加藤 量広, 柿坂 庸介, 中里 信和

    臨床神経生理学　42　(5)　352-352　2014/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  95. Earlier tachycardia onset in right than left mesial temporal lobe seizures Peer-reviewed

    Kazuhiro Kato, Kazutaka Jin, Hisashi Itabashi, Masaki Iwasaki, Yosuke Kakisaka, Masashi Aoki, Nobukazu Nakasato

    NEUROLOGY　83　(15)　1332-1336　2014/10

    DOI： 10.1212/WNL.0000000000000864 　

    ISSN： 0028-3878

    eISSN： 1526-632X

  96. 左右半球に独立性の発作起始を認めるてんかん患者における発作時心拍変化

    加藤 量広, 神 一敬, 柿坂 庸介, 北澤 悠, 岩崎 真樹, 青木 正志, 中里 信和

    てんかん研究　32　(2)　490-490　2014/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  97. Prolonged depersonalization/derealization-like symptom after migraine headache: a case report Peer-reviewed

    Yosuke Kakisaka, Mayu Fujikawa, Sunao Kaneko, Nobukazu Nakasato

    NEUROLOGICAL SCIENCES　35　(9)　1483-1484　2014/09

    DOI： 10.1007/s10072-014-1799-0 　

    ISSN： 1590-1874

    eISSN： 1590-3478

  98. Cephalic aura after frontal lobe resection Peer-reviewed

    Yosuke Kakisaka, Lara Jehi, Rafeed Alkawadri, Zhong I. Wang, Rei Enatsu, John C. Mosher, Anne-Sophie Dubarry, Andreas V. Alexopoulos, Richard C. Burgess

    JOURNAL OF CLINICAL NEUROSCIENCE　21　(8)　1450-1452　2014/08

    DOI： 10.1016/j.jocn.2013.11.024 　

    ISSN： 0967-5868

    eISSN： 1532-2653

  99. Pediatric-Onset Extracephalic Stabbing Pain Peer-reviewed

    Yosuke Kakisaka, Shinsuke Kano, Naomi Hino-Fukuyo, Mitsugu Uematsu, Shigeo Kure

    JOURNAL OF CHILD NEUROLOGY　29　(8)　NP47-NP48　2014/08

    DOI： 10.1177/0883073813498643 　

    ISSN： 0883-0738

    eISSN： 1708-8283

  100. Neonatal "Seizure" While Riding in a Car A Peculiar but Key Episode for Diagnosis of Benign Neonatal Sleep Myoclonus Peer-reviewed

    Yosuke Kakisaka, Tomoichiro Ohara, Naomi Hino-Fukuyo, Mitsugu Uematsu, Shigeo Kure

    CLINICAL PEDIATRICS　53　(6)　605-606　2014/06

    DOI： 10.1177/0009922813491314 　

    ISSN： 0009-9228

    eISSN： 1938-2707

  101. Linking MRI Postprocessing with Magnetic Source Imaging in MRI-negative Epilepsy Peer-reviewed

    Zhong I. Wang, Andreas V. Alexopoulos, Stephen E. Jones, Imad M. Najm, Aleksandar Ristic, Chong Wong, Richard Prayson, Felix Schneider, Yosuke Kakisaka, Shuang Wang, William Bingaman, Jorge A. Gonzalez-Martinez, Richard C. Burgess

    ANNALS OF NEUROLOGY　75　(5)　759-770　2014/05

    DOI： 10.1002/ana.24169 　

    ISSN： 0364-5134

    eISSN： 1531-8249

  102. [Chronic anemia, neutropenia and peculiar bone change seen in total parenteral nutrition]. Peer-reviewed

    Kakisaka Y, Fukuyo N

    No to hattatsu = Brain and development　46　(3)　167-168　2014/05

    ISSN： 0029-0831

  103. Temporal intermittent rhythmic delta activity and abdominal migraine Peer-reviewed

    Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Nobukazu Nakasato

    NEUROLOGICAL SCIENCES　35　(4)　627-628　2014/04

    DOI： 10.1007/s10072-013-1625-0 　

    ISSN： 1590-1874

    eISSN： 1590-3478

  104. Another case with relapsing polychondritis-like ear disease. Peer-reviewed

    Kakisaka Y, Hino-Fukuyo N, Uematsu M, Kure S

    Pediatr Neonat Care Open Access　2　108-108　2014

  105. Exanthema subitum and redness at a BCG inoculation site: An additional clinical evidence. Peer-reviewed

    Kakisaka Y, Hino-Fukuyo N, Uematsu M, Kure S

    Pediatr Neonat Care Open Access　2014　(2)　107-107　2014

  106. Seizure Freedom after Lamotrigine Rash: A Peculiar Phenomenon in Epilepsy Peer-reviewed

    Yosuke Kakisaka, Kazutaka Jin, Kazuhiro Kato, Masaki Iwasaki, Nobukazu Nakasato

    INTERNAL MEDICINE　53　(21)　2521-2522　2014

    DOI： 10.2169/internalmedicine.53.2284 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  107. Abdominal and Lower Back Pain in Pediatric Idiopathic Stabbing Headache Peer-reviewed

    Yosuke Kakisaka, Tomoichiro Ohara, Naomi Hino-Fukuyo, Mitsugu Uematsu, Shigeo Kure

    PEDIATRICS　133　(1)　E245-E247　2014/01

    DOI： 10.1542/peds.2013-0793 　

    ISSN： 0031-4005

    eISSN： 1098-4275

  108. Periodic eye movements and epileptic spasms in west syndrome Peer-reviewed

    Yosuke Kakisaka, Tomoko Kobayashi, Naomi Hino-Fukuyo, Mitsugu Uematsu, Yurika Numata, Masato Mori, Shigeo Kure

    Journal of Child Neurology　28　(11)　1483-1484　2013/11

    DOI： 10.1177/0883073813489169 　

    ISSN： 0883-0738 1708-8283

    eISSN： 1708-8283

  109. The usefulness of subtraction ictal SPECT and ictal near-infrared spectroscopic topography in patients with West syndrome Peer-reviewed

    Kazuhiro Haginoya, Mitsugu Uematsu, Mitsutoshi Munakata, Yosuke Kakisaka, Atsuo Kikuchi, Tojo Nakayama, Naomi Hino-Fukuyo, Rie Tsuburaya, Taro Kitamura, Ikuko Sato-Shirai, Yu Abe, Yoko Matsumoto, Keisuke Wakusawa, Tomoko Kobayashi, Mamiko Ishitobi, Noriko Togashi, Masaki Iwasaki, Nobukazu Nakasato, Kazuie Iinuma

    BRAIN & DEVELOPMENT　35　(10)　887-893　2013/11

    DOI： 10.1016/j.braindev.2013.08.011 　

    ISSN： 0387-7604

    eISSN： 1872-7131

  110. Localization of the ictal onset zone with MEG using minimum norm estimate of a narrow band at seizure onset versus standard single current dipole modeling Peer-reviewed

    Rafeed Alkawadri, Balu Krishnan, Yosuke Kakisaka, Dileep Nair, John C. Mosher, Richard C. Burgess, Andreas V. Alexopoulos

    CLINICAL NEUROPHYSIOLOGY　124　(9)　1915-1918　2013/09

    DOI： 10.1016/j.clinph.2013.03.016 　

    ISSN： 1388-2457

  111. Head Turning Associated With Involuntary Gaze Deviation Peer-reviewed

    Yosuke Kakisaka, Naomi Hino-Fukuyo, Shigeo Kure

    PEDIATRIC NEUROLOGY　49　(2)　144-144　2013/08

    DOI： 10.1016/j.pediatrneurol.2013.04.023 　

    ISSN： 0887-8994

  112. Feasibility of magnetoencephalography recording in an epilepsy patient with implanted responsive cortical stimulation device Peer-reviewed

    Zhong Irene Wang, Andreas V. Alexopoulos, Dileep Nair, Balu Krishnan, John C. Mosher, Richard C. Burgess, Yosuke Kakisaka

    CLINICAL NEUROPHYSIOLOGY　124　(8)　1705-1706　2013/08

    DOI： 10.1016/j.clinph.2013.01.019 　

    ISSN： 1388-2457

  113. Utility of temporally-extended signal space separation algorithm for magnetic noise from vagal nerve stimulators Peer-reviewed

    Yosuke Kakisaka, John C. Mosher, Zhong I. Wang, Kazutaka Jin, Anne-Sophie Dubarry, Andreas V. Alexopoulos, Richard C. Burgess

    CLINICAL NEUROPHYSIOLOGY　124　(7)　1277-1282　2013/07

    DOI： 10.1016/j.clinph.2012.03.082 　

    ISSN： 1388-2457

  114. Asymmetric Drug-Induced Tremor: Rare Feature of a Common Event Peer-reviewed

    Yosuke Kakisaka, Satoko Ito, Tomoichiro Ohara, Naomi Hino-Fukuyo, Mitsugu Uematsu, Shigeo Kure

    PEDIATRIC NEUROLOGY　48　(6)　479-480　2013/06

    DOI： 10.1016/j.pediatrneurol.2013.03.004 　

    ISSN： 0887-8994

  115. Magnetoencephalography correlate of EEG POSTS (positive occipital sharp transients of sleep) Peer-reviewed

    Yosuke Kakisaka, Zhong I. Wang, Rei Enatsu, Anne-Sophie Dubarry, John C. Mosher, Andreas V. Alexopoulos, Richard C. Burgess

    Journal of Clinical Neurophysiology　30　(3)　235-237　2013/06

    DOI： 10.1097/WNP.0b013e31827681a3 　

    ISSN： 0736-0258 1537-1603

  116. Lower Back Pain as a Symptom of Migrainous Corpalgia Peer-reviewed

    Yosuke Kakisaka, Tomoichiro Ohara, Saori Katayama, Tasuku Suzuki, Naomi Hino-Fukuyo, Mitsugu Uematsu, Shigeo Kure

    JOURNAL OF CHILD NEUROLOGY　28　(5)　676-677　2013/05

    DOI： 10.1177/0883073813478170 　

    ISSN： 0883-0738

  117. Yield of repeat routine MEG recordings in clinical practice Peer-reviewed

    Rafeed Alkawadri, Richard Burgess, Cigdem Isitan, Irene Z. Wang, Yosuke Kakisaka, Andreas V. Alexopoulos

    EPILEPSY & BEHAVIOR　27　(2)　416-419　2013/05

    DOI： 10.1016/j.yebeh.2013.02.028 　

    ISSN： 1525-5050

  118. Another Case of Lower Back Pain Associated With Migraine: The Importance of Specific Questions Peer-reviewed

    Yosuke Kakisaka, Tomoichiro Ohara, Saori Katayama, Tasuku Suzuki, Naomi Hino-Fukuyo, Mitsugu Uematsu, Shigeo Kure

    JOURNAL OF CHILD NEUROLOGY　28　(5)　680-680　2013/05

    DOI： 10.1177/0883073813483366 　

    ISSN： 0883-0738

  119. Infantile tullio phenomenon Peer-reviewed

    Yosuke Kakisaka, Naomi Hino-Fukuyo, Hiromitsu Miyazaki, Shigeo Kure

    Journal of Pediatrics　162　(4)　880　2013/04

    DOI： 10.1016/j.jpeds.2012.10.049 　

    ISSN： 0022-3476 1097-6833

  120. Sensitivity of scalp 10-20 EEG and magnetoencephalography Peer-reviewed

    Yosuke Kakisaka, Rafeed Alkawadri, Zhong I. Wang, Rei Enatsu, John C. Mosher, Anne-Sophie Dubarry, Andreas V. Alexopoulos, Richard C. Burgess

    EPILEPTIC DISORDERS　15　(1)　27-31　2013/03

    DOI： 10.1684/epd.2013.0554 　

    ISSN： 1294-9361

  121. Magnetoencephalography Reveals a Unique Neurophysiological Profile of Focal-Onset Epileptic Spasms Peer-reviewed

    Yosuke Kakisaka, Ajay Gupta, Rei Enatsu, Zhong I. Wang, Andreas V. Alexopoulos, John C. Mosher, Anne-Sophie Dubarry, Naomi Hino-Fukuyo, Richard C. Burgess

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　229　(2)　147-151　2013/02

    DOI： 10.1620/tjem.229.147 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  122. Magnetic source imaging and ictal SPECT in MRI-negative neocortical epilepsies: Additional value and comparison with intracranial EEG Peer-reviewed

    Felix Schneider, Z. Irene Wang, Andreas V. Alexopoulos, Salah Almubarak, Yosuke Kakisaka, Kazutaka Jin, Dileep Nair, John C. Mosher, Imad M. Najm, Richard C. Burgess

    EPILEPSIA　54　(2)　359-369　2013/02

    DOI： 10.1111/epi.12004 　

    ISSN： 0013-9580

  123. Extremely low-dose vigabatrin for West syndrome with tuberous sclerosis Peer-reviewed

    Naomi Hino-Fukuyo, Yuko Sato, Yosuke Kakisaka, Wakaba Endo, Yuki Kubota, Atsuo Kikuchi, Tomoko Kobayashi, Kazuhiro Haginoya, Mitsugu Uematsu, Yurika Numata, Hiroshi Doi, Masato Mori, Hitoshi Osaka, Shigeo Kure

    Journal of Pediatric Epilepsy　2　(4)　255-258　2013

    DOI： 10.3233/PEP-14064 　

    ISSN： 2146-4588 2146-457X

  124. Additional evidence that the ryanodine receptor gene (RYR1) causes malignant hyperthermia and severe skeletal malformations Peer-reviewed

    Yosuke Kakisaka, Kazuhiro Haginoya, Yuko Takahashi, Tatsuhiro Ochiai, Ikuma Fujiwara, Atsuo Kikuchi, Keisuke Wakusawa, Satoru Kobayashi, Hirosato Kikuchi, Yasuko Ichihara, Shinichiro Takahashi, Ichizo Nishino

    AMERICAN JOURNAL OF MEDICAL GENETICS PART A　161A　(1)　234-235　2013/01

    DOI： 10.1002/ajmg.a.35678 　

    ISSN： 1552-4825

  125. Utility of Thallium-201 Scintigraphy in Tolosa-Hunt Syndrome Peer-reviewed

    Yosuke Kakisaka, Tomoko Kobayashi, Mitsugu Uematsu, Yurika Numata, Mieko Hirose, Naomi Hino-Fukuyo, Shigeru Tsuchiya, Hiroshi Doi, Hiroshi Fukuda, Shigeo Kure

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　229　(1)　83-86　2013/01

    DOI： 10.1620/tjem.229.83 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  126. Reorganization of posterior language area in temporal lobe epilepsy: A cortico-cortical evoked potential study Peer-reviewed

    Rei Enatsu, Yuichi Kubota, Yosuke Kakisaka, Juan Bulacio, Zhe Piao, Timothy O'Connor, Karl Horning, John Mosher, Richard C. Burgess, William Bingaman, Dileep R. Nair

    EPILEPSY RESEARCH　103　(1)　73-82　2013/01

    DOI： 10.1016/j.eplepsyres.2012.07.008 　

    ISSN： 0920-1211

  127. Human Herpes Virus Type 6 Can Cause Skin Lesions at the BCG Inoculation Site Similar to Kawasaki Disease Peer-reviewed

    Yosuke Kakisaka, Tomoichiro Ohara, Saori Katayama, Tasuku Suzuki, Shu Sasai, Naomi Hino-Fukuyo, Shigeo Kure

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　228　(4)　351-353　2012/12

    DOI： 10.1620/tjem.228.351 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  128. Imag(in)ing seizure propagation: MEG-guided interpretation of epileptic activity from a deep source Peer-reviewed

    Zhong I. Wang, Kazutaka Jin, Yosuke Kakisaka, John C. Mosher, William E. Bingaman, Prakash Kotagal, Richard C. Burgess, Imad M. Najm, Andreas V. Alexopoulos

    HUMAN BRAIN MAPPING　33　(12)　2797-2801　2012/12

    DOI： 10.1002/hbm.21401 　

    ISSN： 1065-9471

  129. Magnetoencephalography in fronto-parietal opercular epilepsy Peer-reviewed

    Yosuke Kakisaka, Masaki Iwasaki, Andreas V. Alexopoulos, Rei Enatsu, Kazutaka Jin, Zhong I. Wang, John C. Mosher, Anne-Sophie Dubarry, Dileep R. Nair, Richard C. Burgess

    EPILEPSY RESEARCH　102　(1-2)　71-77　2012/11

    DOI： 10.1016/j.eplepsyres.2012.05.003 　

    ISSN： 0920-1211

  130. Panax Ginseng: A Newly Identified Cause of Gynecomastia Peer-reviewed

    Yosuke Kakisaka, Tomoichiro Ohara, Hideo Tozawa, Shun Sato, Saori Katayama, Tasuku Suzuki, Naomi Hino-Fukuyo, Shigeo Kure

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　228　(2)　143-145　2012/10

    DOI： 10.1620/tjem.228.143 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  131. Interconnections in superior temporal cortex revealed by musicogenic seizure propagation Peer-reviewed

    Z. Irene Wang, Kazutaka Jin, Yosuke Kakisaka, Richard C. Burgess, Jorge A. Gonzalez-Martinez, Shuang Wang, Susumu Ito, John C. Mosher, Stephen Hantus, Andreas V. Alexopoulos

    JOURNAL OF NEUROLOGY　259　(10)　2251-2254　2012/10

    DOI： 10.1007/s00415-012-6556-9 　

    ISSN： 0340-5354

  132. Hallucinations associated with cerebrospinal fluid leakage after a lumbar puncture Peer-reviewed

    Y. Kakisaka, N. Hino-Fukuyo, T. Kobayashi, Y. Kubota, A. Kikuchi, W. Endo, Y. Sato, S. Kawashima, S. Kure

    BRITISH JOURNAL OF ANAESTHESIA　109　(3)　465-466　2012/09

    DOI： 10.1093/bja/aes289 　

    ISSN： 0007-0912

  133. Use of simultaneous depth and MEG recording may provide complementary information regarding the epileptogenic region Peer-reviewed

    Yosuke Kakisaka, Yuichi Kubota, Zhong I. Wang, Zhe Piao, John C. Mosher, Jorge Gonzalez-Martinez, Kazutaka Jin, Andreas V. Alexopoulos, Richard C. Burgess

    EPILEPTIC DISORDERS　14　(3)　298-303　2012/09

    DOI： 10.1684/epd.2012.0517 　

    ISSN： 1294-9361

  134. Abdominal migraine reviewed from both central and peripheral aspects. Peer-reviewed

    Kakisaka Y, Uematsu M, Wang ZI, Haginoya K

    World journal of experimental medicine　2　(4)　75-77　2012/08

    DOI： 10.5493/wjem.v2.i4.75 　

  135. Clinical evidence for the utility of movement compensation algorithm in magnetoencephalography: Successful localization during focal seizure Peer-reviewed

    Yosuke Kakisaka, Zhong I. Wang, John C. Mosher, Anne-Sophie Dubarry, Andreas V. Alexopoulos, Rei Enatsu, Prakash Kotagal, Richard C. Burgess

    EPILEPSY RESEARCH　101　(1-2)　191-196　2012/08

    DOI： 10.1016/j.eplepsyres.2012.03.014 　

    ISSN： 0920-1211

  136. Voxel-based morphometric MRI post-processing in MRI-negative focal cortical dysplasia followed by simultaneously recorded MEG and stereo-EEG Peer-reviewed

    Z. I. Wang, S. E. Jones, A. J. Ristic, C. Wong, Y. Kakisaka, K. Jin, F. Schneider, J. A. Gonzalez-Martinez, J. C. Mosher, D. Nair, R. C. Burgess, I. M. Najm, A. V. Alexopoulos

    EPILEPSY RESEARCH　100　(1-2)　188-193　2012/06

    DOI： 10.1016/j.eplepsyres.2012.02.011 　

    ISSN： 0920-1211

  137. Magnetic source imaging in non-lesional neocortical epilepsy: Additional value and comparison with ICEEG Peer-reviewed

    Felix Schneider, Andreas V. Alexopoulos, Zhong Wang, Salah Almubarak, Yosuke Kakisaka, Kazutaka Jin, Dileep Nair, John C. Mosher, Imad M. Najm, Richard C. Burgess

    EPILEPSY & BEHAVIOR　24　(2)　234-240　2012/06

    DOI： 10.1016/j.yebeh.2012.03.029 　

    ISSN： 1525-5050

  138. Hypoperfusion in caudate nuclei in patients with brain-lung-thyroid syndrome Peer-reviewed

    Mitsugu Uematsu, Kazuhiro Haginoya, Atsuo Kikuchi, Tojo Nakayama, Yosuke Kakisaka, Yurika Numata, Tomoko Kobayashi, Naomi Hino-Fukuyo, Ikuma Fujiwara, Shigeo Kure

    JOURNAL OF THE NEUROLOGICAL SCIENCES　315　(1-2)　77-81　2012/04

    DOI： 10.1016/j.jns.2011.11.025 　

    ISSN： 0022-510X

  139. Intractable focal epilepsy contralateral to the side of facial atrophy in Parry-Romberg syndrome Peer-reviewed

    Yosuke Kakisaka, Norman K. So, Stephen E. Jones, Zhong I. Wang, John C. Mosher, Andreas V. Alexopoulos, Richard C. Burgess

    NEUROLOGICAL SCIENCES　33　(1)　165-168　2012/02

    DOI： 10.1007/s10072-011-0643-z 　

    ISSN： 1590-1874

  140. Magnetoencephalography's higher sensitivity to epileptic spikes may elucidate the profile of electroencephalographically negative epileptic seizures Peer-reviewed

    Yosuke Kakisaka, Zhong I. Wang, John C. Mosher, Dileep R. Nair, Andreas V. Alexopoulos, Richard C. Burgess

    EPILEPSY & BEHAVIOR　23　(2)　171-173　2012/02

    DOI： 10.1016/j.yebeh.2011.09.019 　

    ISSN： 1525-5050

  141. 咽頭筋麻痺を認めない咽頭頸部上腕型Guillain-Barre症候群の1例

    沼田 有里佳, 植松 貢, 福與 なおみ, 柿坂 庸介, 小林 朋子, 廣瀬 三恵子, 萩野谷 和裕, 土屋 滋

    脳と発達　43　(6)　482-485　2011/11

    Publisher: (一社)日本小児神経学会

    ISSN： 0029-0831

    eISSN： 1884-7668

  142. Lateralization of interictal spikes after corpus callosotomy Peer-reviewed

    Masaki Iwasaki, Nobukazu Nakasato, Yosuke Kakisaka, Akitake Kanno, Mitsugu Uematsu, Kazuhiro Haginoya, Teiji Tominaga

    CLINICAL NEUROPHYSIOLOGY　122　(11)　2121-2127　2011/11

    DOI： 10.1016/j.clinph.2011.04.013 　

    ISSN： 1388-2457

  143. Different cortical involvement pattern of generalized and localized spasms: A magnetoencephalography study Peer-reviewed

    Yosuke Kakisaka, Ajay Gupta, Zhong I. Wang, Anne-Sophie Dubarry, John C. Mosher, Richard C. Burgess

    EPILEPSY & BEHAVIOR　22　(3)　599-601　2011/11

    DOI： 10.1016/j.yebeh.2011.08.011 　

    ISSN： 1525-5050

  144. A case of a pharyngeal-cervical-brachial variant of Guillain-Barré syndrome without pharyngeal palsy Peer-reviewed

    Yurika Numata, Mitsugu Uematsu, Naomi Hino-Fukuyo, Yosuke Kakisaka, Tomoko Kobayashi, Mieko Hirose, Kazuhiro Haginoya, Shigeru Tsuchiya

    No To Hattatsu　43　(6)　482-485　2011/11

    DOI： 10.11251/ojjscn.43.482 　

    ISSN： 0029-0831

  145. 塩化タリウムシンチが診断に有用と考えられたTolosa-Hunt症候群の1例

    小林 朋子, 植松 貢, 沼田 有里佳, 柿坂 庸介, 土屋 滋

    脳と発達　43　(Suppl.)　S297-S297　2011/05

    Publisher: (一社)日本小児神経学会

    ISSN： 0029-0831

    eISSN： 1884-7668

  146. Somatotopic distribution of peri-rolandic spikes may predict prognosis in pediatric-onset epilepsy with sensorimotor seizures Peer-reviewed

    Yosuke Kakisaka, Masaki Iwasaki, Kazuhiro Haginoya, Akitake Kanno, Shigeru Tsuchiya, Nobukazu Nakasato

    CLINICAL NEUROPHYSIOLOGY　122　(5)　869-873　2011/05

    DOI： 10.1016/j.clinph.2010.09.026 　

    ISSN： 1388-2457

  147. Generalized 3-Hz spike-and-wave complexes emanating from focal epileptic activity in pediatric patients Peer-reviewed

    Yosuke Kakisaka, Andreas V. Alexopoulos, Ajay Gupta, Zhong I. Wang, John C. Mosher, Masaki Iwasaki, Richard C. Burgess

    EPILEPSY & BEHAVIOR　20　(1)　103-106　2011/01

    DOI： 10.1016/j.yebeh.2010.10.025 　

    ISSN： 1525-5050

  148. Unique discrepancy between cerebral blood flow and glucose metabolism in hemimegalencephaly Peer-reviewed

    Mitsugu Uematsu, Kazuhiro Haginoya, Noriko Togashi, Naomi Hino-Fukuyo, Tojo Nakayama, Atsuo Kikuchi, Yu Abe, Keisuke Wakusawa, Yoko Matsumoto, Yosuke Kakisaka, Tomoko Kobayashi, Mieko Hirose, Hiroyuki Yokoyama, Kazuie Iinuma, Masaki Iwasaki, Nobukazu Nakasato, Tomohiro Kaneta, Manami Akasaka, Atsushi Kamei, Shigeru Tsuchiya

    EPILEPSY RESEARCH　92　(2-3)　201-208　2010/12

    DOI： 10.1016/j.eplepsyres.2010.09.010 　

    ISSN： 0920-1211

    eISSN： 1872-6844

  149. Restless legs syndrome: A unique case of relapse after traffic accidents with a long remission Peer-reviewed

    Yosuke Kakisaka, Kazuhiro Haginoya, Mitsugu Uematsu, Shigeru Tsuchiya

    SLEEP MEDICINE　11　(6)　596-597　2010/06

    DOI： 10.1016/j.sleep.2010.02.005 　

    ISSN： 1389-9457

  150. Abdominal Migraine Associated with Ecchymosis of the Legs and Buttocks: Does the Symptom Imply an Unknown Mechanism of Migraine? Peer-reviewed

    Yosuke Kakisaka, Keisuke Wakusawa, Kazuhiro Haginoya, Mitsugu Uematsu, Shigeru Tsuchiya

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　221　(1)　49-51　2010/05

    DOI： 10.1620/tjem.221.49 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  151. Efficacy of Sumatriptan in Two Pediatric Cases With Abdominal Pain-Related Functional Gastrointestinal Disorders: Does the Mechanism Overlap That of Migraine? Peer-reviewed

    Yosuke Kakisaka, Keisuke Wakusawa, Kazuhiro Haginoya, Akiko Saito, Mitsugu Uematsu, Hiroyuki Yokoyama, Tetsuo Sato, Shigeru Tsuchiya

    JOURNAL OF CHILD NEUROLOGY　25　(2)　234-237　2010/02

    DOI： 10.1177/0883073809336875 　

    ISSN： 0883-0738

  152. Successful Treatment With Sumatriptan in a Case With Cyclic Vomiting Syndrome Combined With 18q-Syndrome Peer-reviewed

    Yosuke Kakisaka, Keisuke Wakusawa, Ikuko Sato, Kazuhiro Haginoya, Mitsugu Uematsu, Mieko Hirose, Mitsutoshi Munakata, Tetsuo Sato, Shigeru Tsuchiya

    JOURNAL OF CHILD NEUROLOGY　24　(12)　1561-1563　2009/12

    DOI： 10.1177/0883073809334384 　

    ISSN： 0883-0738

  153. Sensorimotor seizures of pediatric onset with unusual posteriorly oriented rolandic spikes Peer-reviewed

    Yosuke Kakisaka, Nobukazu Nakasato, Kazuhiro Haginoya, Akitake Kanno, Shigeru Tsuchiya

    EPILEPSY RESEARCH　84　(2-3)　153-158　2009/04

    DOI： 10.1016/j.eplepsyres.2009.01.012 　

    ISSN： 0920-1211

    eISSN： 1872-6844

  154. Utility of subtraction ictal SPECT images in detecting focal leading activity and understanding the pathophysiology of spasms in patients with West syndrome Peer-reviewed

    Yosuke Kakisaka, Kazuhiro Haginoya, Mamiko Ishitobi, Noriko Togashia, Taro Kitamura, Keisuke Wakusawa, Ikuko Sato, Naomi Hino-Fukuyo, Mitsugu Uematsu, Mitsutoshi Munakata, Hiroyuki Yokoyama, Kazuie Iinuma, Tomohiro Kaneta, Shuichi Higano, Shigeru Tsuchiya

    EPILEPSY RESEARCH　83　(2-3)　177-183　2009/02

    DOI： 10.1016/j.eplepsyres.2008.11.005 　

    ISSN： 0920-1211

  155. Ictal Vomiting as an Initial Symptom of Severe Myoclonic Epilepsy in Infancy: A Case Report Peer-reviewed

    Naomi Hino-Fukuyo, Kazuhiro Haginoya, Noriko Togashi, Mitsugu Uematsu, Taro Kitamura, Yosuke Kakisaka, Mamiko Ishitobi, Keisuke Wakusawa, Kazuie Iinuma, Hirokazu Oguni, Kazuhiro Yamakawa, Shigeru Tsuchiya

    JOURNAL OF CHILD NEUROLOGY　24　(2)　228-230　2009/02

    DOI： 10.1177/0883073808327839 　

    ISSN： 0883-0738

  156. Kakisaka Y, Nakasato N, Haginoya K, Tsuchiya S

    Pediatric-onset rolandic seizure showing posteriorly-oriented rolandic spikes

    Clin. Neurophysiol　2009　(120)　e149-e149　2009

  157. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term enteral nutrition Peer-reviewed

    Mitsutoshi Munakata, Kaori Kobayashi, Junko Niisato-Nezu, Souichiro Tanaka, Yosuke Kakisaka, Takae Ebihara, Satoru Ebihara, Kazuhiro Haginoya, Shigeru Tsuchiya, Akira Onuma

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　214　(4)　327-332　2008/04

    DOI： 10.1620/tjem.214.327 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  158. Malignant rolandic-sylvian epilepsy in children(MRSE)におけるIMZ SPECT

    北村 太郎, 萩野谷 和裕, 柿坂 庸介, 植松 貢, 福與 なおみ, 冨樫 紀子, 横山 浩之, 奈良 千恵子, 宗形 光敏, 廣瀬 三恵子, 涌澤 圭介, 佐藤 育子, 小林 朋子, 松本 葉子, 飯沼 一宇

    脳と発達　39　(Suppl.)　S326-S326　2007/06

    Publisher: (一社)日本小児神経学会

    ISSN： 0029-0831

    eISSN： 1884-7668

  159. Neonatal-onset brainstem reticular reflex myoclonus following a prenatal brain insult: Generalized myoclonic jerk and a brainstem lesion Peer-reviewed

    Yosuke Kakisaka, Kazuhiro Haginoya, Noriko Togashi, Taro Kitamiura, Mitsugu Uematsu, Naomi Hino-Fukuyo, Shigeo Kure, Junko Saito, Setsuko Kitaoka, Shuei Watanabe, Hideto Yoshikawa, Takahiro Nara, Yoichi Suzuki, Shigeru Tsuchiya

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　211　(3)　303-308　2007/03

    DOI： 10.1620/tjem.211.303 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  160. Successful treatment of a 2-year-old girl with intractable myasthenia gravis using tacrolimus Peer-reviewed

    Yosuke Kakisaka, Kazuhiro Haginoya, Hiroyuki Yokoyama, Mamiko Ishitobi, Keisuke Wakusawa, Ikuko Sato, Noriko Togashi, Taro Kitamura, Naomi Fukuyo, Yasushi Yoshihara, Kazuie Iinuma

    BRAIN & DEVELOPMENT　28　(8)　534-536　2006/09

    DOI： 10.1016/j.braindev.2006.02.001 　

    ISSN： 0387-7604

  161. Epileptic focus analysis in childhood epilepsy by using IMZ-SPECT Peer-reviewed

    Kitamura Taro, Kakisaka Yosuke, Haginoya Kazuhiro, Nakasato Nobukazu, Shamoto Hiroshi, Kaneta Tomohiro

    EPILEPSIA　47　85　2006

    ISSN： 0013-9580

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    池之内初, 柿坂庸介, 浮城一司

    医学教育　56　(1)　36-37　2025/02

  4. 東北大学医学部教室員会が主導する医学生や若手医師の英語論文執筆支援の取り組み―辛酉会との後進育成のための協働―． Peer-reviewed

    柿坂庸介, 荒田悠太郎, 横川裕大, 唐澤秀明, 後岡広太郎, 多田寛, 大田英揮

    東北医誌　137　33-34　2025

  5. 東北医学雑誌における症例報告部門開設の意義と成果． Peer-reviewed

    柿坂庸介, 唐澤秀明, 後岡広太郎, 多田寛, 大田英揮, 高瀬圭, 八重樫伸生, 石井直人, 大田千晴

    東北医誌　137　31-32　2025

  6. 小学校教諭免許を有する医学生から見た、医学教育における論文作成等の”探究的学修”活動に対する考察 Peer-reviewed

    木村颯介, 柿坂庸介, 浮城一司

    医学教育　55　350-351　2024/08

  7. 海馬硬化を伴う内側側頭葉てんかん患者における側頭葉深部の脳磁図棘波信号源の臨床的意義. Peer-reviewed

    大村花薫子, 石田 誠, 柿坂庸介, 神 一敬, 大沢伸一郎, 中里信和

    日本生体磁気学会誌　37　140-141　2024/06

  8. 医学専門教育開始前の学修者に焦点を当てた論文執筆教育の試み-医学教育誌に掲載された論考を活用して-. Peer-reviewed

    柿坂庸介, 佐々木拓也, 浮城一司

    医学教育　55　268-269　2024/06

  9. 症例報告の添削過程を録画し、著者と共有する教育的取り組み. Peer-reviewed

    柿坂庸介, 多田寛, 森下葵, 浮城一司, 大田千晴

    医学教育　55　264-265　2024/06

  10. 医療者の臨床・研究・教育活動を哲学の観点で位置づけし教育に生かす試み Peer-reviewed

    柿坂庸介, 此松和俊, 久保田隆文

    医学教育　55　52-52　2024/02

  11. 精神科医にどのようにすれば「てんかん医療」を好きになってもらえるか. Invited

    柿坂庸介

    臨床精神医学　53　165-170　2024/02

  12. 「症例報告の書き方」講義と執筆支援が系統講義終了前の医学生にもたらす内的変化

    佐々木 拓也, 柿坂 庸介, 亀岡 淳一

    医学教育　54　(5)　490-491　2023/10

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  13. 多岐にわたる進路希望を持つ高校生に対する医学講義において探究学習の要素を導入した教育経験 Peer-reviewed

    柿坂庸介

    医学教育　54　316-317　2023/06

  14. 実践報告-新たな試み 医学科における「症例報告の書き方」教育法の模索

    柿坂 庸介

    医学教育　54　(2)　209-215　2023/04

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  15. The validity and reliability of the Japanese version of Medical Outcomes Study Social Support Survey for patients with epilepsy

    高橋健人, 藤川真由, 藤川真由, 藤川真由, 田崎勝也, 小川舞美, 大友風佳, 柿坂庸介, 神一敬, 中里信和

    てんかん研究　41　(2)　2023

    ISSN： 0912-0890

  16. ECD direction of interictal neuromagnegtic spikes in patients with temporal lobe epilepsy with amygdala enlargement.

    Konomatsu K, Jin K, Ishida M, Sato S, Morishita Y, Soga T, Ukishiro K, Kakisaka Y, Kanno A, Mugikura S, Aoki M, Nakasato N

    J Jpn Biomag.　36　158-159　2023

  17. 側頭葉てんかん患者において深部に推定される発作間欠時棘波信号源の臨床的意義

    石田 誠, 大村 花薫子, 神 一敬, 菅野 彰剛, 大沢 伸一郎, 柿坂 庸介, 安藤 康夫, 中里 信和

    日本生体磁気学会誌　36　(1)　160-161　2023

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  18. 扁桃体腫大を伴う側頭葉てんかん患者における脳磁図所見の特徴

    此松 和俊, 神 一敬, 石田 誠, 佐藤 志帆, 森下 陽平, 曽我 天馬, 柿坂 庸介, 菅野 彰剛, 麦倉 俊司, 青木 正志, 中里 信和

    日本生体磁気学会誌　35　120-121　2022

  19. 中心溝近傍病変による非典型的な体性感覚機能局在を誘発磁界により予測できた一例

    石田 誠, 柿坂庸介, 菅野 彰剛, 大沢伸一郎, 浮城一司, 神 一敬, 冨永悌二, 中里信和

    日本生体磁気学会誌　34　(1)　142-143　2021/06

  20. 眼球・頭部の向反を伴う焦点意識保持発作を呈する 前頭葉てんかんで脳磁図が局在診断に有用だった一例

    土屋真理夫, 石田誠, 大沢伸一郎, 浮城一司, 柿坂庸介, 菅野彰剛, 神一敬, 張替宗介, 中里信和

    日本生体磁気学会誌　34　(1)　139-141　2021/06

  21. てんかんの地域診療連携体制推進のためのてんかん診療拠点病院運用ガイドラインに関する研究 てんかん診療拠点病院における遠隔診療の役割の調査

    中里信和, 神一敬, 柿坂庸介

    てんかんの地域診療連携体制の推進のためのてんかん診療拠点病院運用ガイドラインに関する研究 令和2年度 総括・分担研究報告書(Web)　2021

  22. Attenuation of N20m during wakefulness with disease duration of temporal lobe epilepsy

    Makoto Ishida, Kazutaka Jin, Yosuke Kakisaka, Akitake Kanno, Ryuta Kasashima, Nobukazu Nakasato

    Journal of Japan Biomagnetism and Bioelectromagnetics Society　33　(1)　62-63　2020/10

    ISSN： 0915-0374

  23. Utility of lower lip stimulation somatosensory evoked magnetic fields : An epilepsy case with right paracentral lobule focal cortical dysplasia

    Akitake Kanno, Kazutaka Jin, Yosuke Kakisaka, Dai Agari, Kazushi Ukishiro, Mario Tsuchiya, Makoto Ishida, Shinichiro Osawa, Teiji Tominaga, Nobukazu Nakasato

    Journal of Japan Biomagnetism and Bioelectromagnetics Society　33　(1)　108-110　2020/10

    ISSN： 0915-0374

  24. CLARA clarifies involvement of insular and cingulate gyrus in generation of gelastic seizure due to left frontal lobe epilepsy.

    Dai Agari, Yosuke Kakisaka, Akitake Kanno, Makoto Ishida, Shinichiro Osawa, Kazutaka Jin, Nobukazu Nakasato

    Journal of Japan Biomagnetism and Bioelectromagnetics Society　33　(1)　117-119　2020/10

  25. Tele-epilepsy conference : How we can maximize an educational effect of teleconference system Peer-reviewed

    15　(2)　127-129　2019/09

    Publisher: 日本遠隔医療学会

    ISSN： 1880-800X

  26. 東北大学病院の「てんかん脳磁図・ベスト・オブ・ザ・ベスト」

    神 一敬, 柿坂庸介, 石田 誠, 菅野彰剛, 岩崎真樹, 川島隆太, 中里信和

    日本生体磁気学会誌　32　(1)　62-63　2019/06

  27. Abnormal somatosensory evoked magnetic fields evoked by posterior tibial nerve stimulation contributed to localization of the epileptogenic focus in a patient with focal epilepsy

    上利大, 神一敬, 神一敬, 柿坂庸介, 柿坂庸介, 菅野彰剛, 石田誠, 中里信和, 中里信和

    日本生体磁気学会誌　32　(1)　194-195　2019/06

    ISSN： 0915-0374

  28. 情報通信技術を活用したてんかんオンライン診療と遠隔医療者教育

    柿坂庸介, 中里信和

    精神科治療学　34　(2)　177-180　2019/02

  29. 脳磁図棘波の信号源推定に平均加算と空間フィルター法の併用が役立った前頭葉てんかんの1症例

    菅野 彰剛, 神 一敬, 大沢 伸一郎, 石田 誠, 柿坂 庸介, 上利 大, 浮城 一司, 土屋 真理夫, 中里 信和

    日本生体磁気学会誌　32　(1)　114-115　2019

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  30. 側頭葉てんかん患者の体性感覚誘発磁界の信号強度は覚醒時のみ抑制される

    石田 誠, 神 一敬, 柿坂 庸介, 菅野 彰剛, 川島 隆太, 中里 信和

    日本生体磁気学会誌　32　(1)　150-151　2019

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  31. 脳磁図の再評価とさらなる発展を目指して 電流双極子のみによらないてんかん波形の解釈 脳磁図とステレオ脳波の同時記録による棘波の検出

    神 一敬, 柿坂 庸介, 中里 信和

    日本生体磁気学会誌　31　(1)　80-81　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  32. 脳磁図の再評価とさらなる発展を目指して 電流双極子のみによらないてんかん波形の解釈 脳磁図とステレオ脳波の同時記録による棘波の検出

    神 一敬, 柿坂 庸介, 中里 信和

    日本生体磁気学会誌　31　(1)　80-81　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  33. 聴覚性前兆を呈した側頭葉てんかん患者における脳波・脳磁図による発作間欠時棘波の信号源推定

    上利 大, 神 一敬, 柿坂 庸介, 菅野 彰剛, 石田 誠, 中里 信和

    日本生体磁気学会誌　31　(1)　104-105　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  34. 【てんかん診療-すべての医師のための診断・治療のコツ-】 てんかんの検査・診断 遠隔てんかん症例検討会

    柿坂 庸介, 上利 大, 大沢 伸一郎, 神 一敬, 中里 信和

    日本臨床　76　(6)　932-936　2018/06

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  35. 聴覚性前兆を呈した側頭葉てんかん患者における脳波・脳磁図による発作間欠時棘波の信号源推定

    上利 大, 神 一敬, 柿坂 庸介, 菅野 彰剛, 石田 誠, 中里 信和

    日本生体磁気学会誌　31　(1)　104-105　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  36. てんかん診療における脳磁図の役割と電流双極子モデルの意味

    柿坂庸介, 神 一敬, 北澤 悠, 上利 大, 高山裕太郎, 菅野彰剛, 中里信和

    31　(1)　42-43　2018/06

  37. Advantages and disadvantages of equivalent current dipole models for EEG and MEG in diagnosing epilepsy

    中里信和, 中里信和, 菅野彰剛, 菅野彰剛, 石田誠, 上利大, 大沢伸一郎, 柿坂庸介, 柿坂庸介, 神一敬, 神一敬

    日本生体磁気学会誌　31　(1)　40-41　2018/06

    ISSN： 0915-0374

  38. 脳磁図は体性感覚誘発性棘波様活動を成人でも観察できる

    石田 誠, 菅野 彰剛, 柿坂 庸介, 神 一敬, 上利 大, 川島 隆太, 中里 信和

    日本生体磁気学会誌　31　(1)　102-103　2018/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  39. てんかん切除術後に主成分分析による脳磁図追加解析が残存発作を説明できた2例

    菅野 彰剛, 神 一敬, 石田誠, 柿坂 庸介, 上利大, 大沢伸一郎, 岩崎真樹, 中里 信和

    日本生体磁気学会誌　31　(1)　100-101　2018/06

  40. 脳磁図とステレオ脳波の同時記録による棘波の検出

    神 一敬, 柿坂 庸介, 中里 信和

    日本生体磁気学会誌　31　(1)　14-15　2018/06

  41. Epilepsy tele-conferencing system

    柿坂 庸介, 上利 大, 大沢 伸一郎, 神 一敬, 中里 信和

    日本臨床　76　(6)　932-936　2018/06

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  42. よく使う日常治療薬の正しい使い方 成人てんかんに対する抗てんかん薬の正しい使い方

    高山 裕太郎, 柿坂 庸介, 中里 信和

    レジデントノート　19　(12)　2169-2172　2017/11

    Publisher: 羊土社

    ISSN： 1344-6746

  43. 【事例から学ぶ(その2)】 てんかん患者の就労支援における医療の役割

    藤川 真由, 岩城 弘隆, 大竹 茜, 柿坂 庸介, 北澤 悠, 神 一敬, 中里 信和

    職業リハビリテーション　31　(1)　3-9　2017/09

    Publisher: 日本職業リハビリテーション学会

    ISSN： 0915-0870

  44. 寝言とみなされていた発作時発話の1例

    鈴木 健大, 柿坂 庸介, 北澤 悠, 神 一敬, 佐藤 志帆, 岩崎 真樹, 藤川 真由, 西尾 慶之, 菅野 彰剛, 中里 信和

    BRAIN and NERVE: 神経研究の進歩　69　(2)　167-171　2017/02

    Publisher: (株)医学書院

    ISSN： 1881-6096

    eISSN： 1344-8129

  45. 多小脳回患者で認められた正中神経刺激体性感覚誘発反応における異常ダイポール回転現象

    北澤 悠, 菅野 彰剛, 神 一敬, 石田 誠, 柿坂 庸介, 田中 章景, 中里 信和

    日本生体磁気学会誌　30　(1)　122-123　2017

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  46. 画像診断 今月の症例 Peer-reviewed

    宮内 隼弥, 柿坂 庸介, 力石 健, 麦倉 俊司, 割田 仁, 小田切 邦雄

    小児科臨床　70　(1)　1-4　2017/01

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  47. てんかん脳磁図の最前線 脳磁図はさまざまな領域の棘波を捉える

    柿坂 庸介, 岩崎 真樹, 神 一敬, 北澤 悠, 菅野 彰剛, 中里 信和

    日本生体磁気学会誌　29　(1)　14-15　2016/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  48. 遊離前腕皮弁による舌再建術後の一次体性感覚誘発磁界反応

    菅野 彰剛, 小枝 聡子, 柿坂 庸介, 中里 信和, 川島 隆太, 杉浦 元亮

    日本生体磁気学会誌　29　(1)　90-91　2016/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  49. 側頭葉てんかん患者における術前MEG言語機能マッピング

    石田 誠, 岩崎 真樹, 菅野 彰剛, 神 一敬, 柿坂 庸介, 川島 隆太, 中里 信和

    日本生体磁気学会誌　29　(1)　128-129　2016/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  50. 画像診断 今月の症例 多嚢胞性卵巣症候群(Polycystic ovary syndrome;PCOS) Peer-reviewed

    前山 俊史, 柿坂 庸介, 大原 朋一郎, 戸澤 秀夫, 小田切 邦雄

    小児科臨床　69　(3)　321-324　2016/03

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  51. 体性感覚誘発性棘波様活動を脳磁図で検出した成人てんかん3例

    石田 誠, 柿坂 庸介, 菅野 彰剛, 岩崎 真樹, 神 一敬, 川島 隆太, 中里 信和

    日本生体磁気学会誌　28　(1)　154-155　2015/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  52. 時間周波数解析による体性感覚誘発磁界反応の評価は遷延性意識障害患者の機能残存の評価に有用である

    菅野 彰剛, 中里 信和, 柿坂 庸介, 長嶺 義秀, 川島 隆太

    日本生体磁気学会誌　28　(1)　68-69　2015/06

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  53. 不快な感覚・尿意切迫感を自覚する単純部分発作を呈した前帯状回てんかんの1例 Peer-reviewed

    吉野 彰兼, 柿坂 庸介, 神 一敬, 加藤 量広, 佐藤 志帆, 藤川 真由, 北澤 悠, 岩崎 真樹, 板橋 尚, 中里 信和

    小児科臨床　68　(6)　1225-1230　2015/06

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  54. 画像診断 今月の症例 異物(竹の箸) Peer-reviewed

    吉野 彰兼, 柿坂 庸介, 大原 朋一郎, 泉山 祐美, 澤村 武, 小田切 邦雄

    小児科臨床　68　(5)　953-956　2015/05

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  55. RELATIONSHIP BETWEEN ICTAL EEG AND NEUROIMAGING FINDINGS IN PATIENTS WITH TEMPORAL LOBE EPILEPSY

    I. Itabashi, K. Jin, S. Sato, M. Iwasaki, Y. Kitazawa, K. Kato, Y. Kakisaka, M. Fujikawa, N. Nakasato

    EPILEPSIA　56　125-126　2015/02

    ISSN： 0013-9580

    eISSN： 1528-1167

  56. PSYCHOSOCIAL ISSUES OF ADOLESCENTS WITH EPILEPSY IN JAPAN

    Y. Kishimoto, M. Fujikawa, K. Kato, Y. Kitazawa, Y. Kakisaka, M. Iwasaki, K. Jin, N. Nakasato

    EPILEPSIA　56　168-168　2015/02

    ISSN： 0013-9580

    eISSN： 1528-1167

  57. EPILEPSY KNOWLEDGE IS THE KEY TOWARDS SOCIAL ACCEPTANCE AMONG UNIVERSITY STUDENTS IN JAPAN

    M. Fujikawa, N. Kaneko, Y. Kakisaka, T. Ueno, N. Nakasato

    EPILEPSIA　56　103-103　2015/02

    ISSN： 0013-9580

    eISSN： 1528-1167

  58. RELATIONSHIP BETWEEN CARDIAC AUTONOMIC DYSREGULATION AND SEIZURE LATERALIZATION IN PATIENTS WITH FOCAL EPILEPSY

    K. Jin, N. Suzuki, K. Kato, Y. Kitazawa, Y. Kakisaka, M. Iwasaki, M. Fujikawa, N. Nakasato

    EPILEPSIA　56　126-126　2015/02

    ISSN： 0013-9580

    eISSN： 1528-1167

  59. てんかんと共に成長する患者の教育について

    柿坂庸介, 藤川真由, 中里信和

    日本神経学会学術大会プログラム・抄録集　56th　2015

  60. 複数の発作周辺期精神症状を含む多彩な発作症状を呈した部分てんかんの1例

    江面 道典, 柿坂 庸介, 神 一敬, 加藤 量広, 岩崎 真樹, 藤川 真由, 青木 正志, 中里 信和

    BRAIN and NERVE: 神経研究の進歩　67　(1)　105-109　2015/01

    Publisher: (株)医学書院

    ISSN： 1881-6096

    eISSN： 1344-8129

  61. ビガバトリンを第一選択に用いた結節性硬化症に伴うウエスト症候群後の1例 Peer-reviewed

    佐藤 優子, 福與 なおみ, 菊池 敦生, 中山 東城, 柿坂 庸介, 久保田 由紀, 遠藤 若葉, 小林 朋子, 萩野谷 和裕, 植松 貢, 沼田 有里佳, 土井 洋, 呉 繁夫

    小児科臨床　67　(6)　1047-1050　2014/06

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  62. 慢性的な貧血と好中球減少症,特徴的な骨X線所見を呈した完全中心静脈栄養の重症心身障害児

    柿坂庸介, 福與なおみ

    脳と発達　46　(3)　167-168　2014/05/01

    ISSN： 0029-0831

  63. MEGによるてんかん病態の解析 脳磁図の"眼"でみるてんかんの病態生理

    柿坂 庸介, 岩崎 真樹, 神 一敬, 加藤 量広, 藤川 真由, 中里 信和

    日本生体磁気学会誌　27　(1)　16-17　2014/05

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  64. てんかん患者の被災直後の実態調査に基づいた災害に強い診療システムの提案

    中里 信和, 柿坂 庸介, 神 一敬, 岩崎 真樹, 渡辺 雅子, 兼子 直

    精神薬療研究年報　(46)　90-91　2014/03

    Publisher: (公財)先進医薬研究振興財団

    ISSN： 1346-1702

  65. 頸部腫脹とアミラーゼ上昇を来した川崎病の1例 超音波検査の可能性 Peer-reviewed

    鈴木 資, 柿坂 庸介, 佐々木 和人, 片山 紗乙莉, 大原 朋一郎

    小児科臨床　67　(1)　135-139　2014/01

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  66. 特徴的な症状を呈した片頭痛の小児例 Peer-reviewed

    片山 紗乙莉, 柿坂 庸介, 佐々木 和人, 鈴木 資, 大原 朋一郎, 呉 繁夫

    小児科臨床　66　(10)　2055-2060　2013/10

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  67. 脳波上hypsarrhythmiaの出現前にspasmが6週間先行したWest症候群の1例 Peer-reviewed

    相原 悠, 福與 なおみ, 柿坂 庸介, 菊池 敦生, 川嶋 明香, 佐藤 優子, 遠藤 若葉, 久保田 由紀, 小林 朋子, 富樫 紀子, 呉 繁夫

    小児科臨床　66　(9)　1899-1903　2013/09

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  68. Marked periosteal hyperostosis: A feature of copper deficiency.

    Kakisaka Y, Hino-Fukuyo N, Uematsu M, Kure S

    Pediatrics e-letter　2012/12

  69. 非定型後方ローランド棘波をもつ小児期発症の感覚運動発作(Sensorimotor seizures of pediatric onset with unusual posteriorly oriented rolandic spikes)

    柿坂 庸介, 中里 信和, 萩野谷 和裕, 菅野 彰剛, 土屋 滋

    てんかん研究　28　(2)　234-234　2010/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  70. 心臓合併症により根治術が困難であった広範囲腸管無神経節症に伴うbacterial overgrowth syndromeに対しsynbiotics療法が有効であった1例 Peer-reviewed

    柿坂 庸介, 三浦 雄一郎, 佐藤 智樹, 松木 茂伸, 中山 信吾, 佐藤 都留雄, 田名部 宗之, 工藤 正文, 鈴木 豊, 神田 進, 澤 直哉, 橋本 剛, 高橋 琢也, 諸富 正己, 土屋 滋

    小児科臨床　63　(1)　81-86　2010/01

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  71. 正中神経刺激体性感覚誘発磁界の同側反応は脳梁離断術に影響されない

    菅野彰剛, 中里信和, 岩崎真樹, 柿坂庸介, 藤原悟

    てんかん研究　27　(2)　277-277　2009/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  72. 脳梁離断による全般性棘波の側性化:半球間潜時差の影響

    岩崎真樹, 中里信和, 柿坂庸介, 菅野彰剛, 植松貢, 萩野谷和裕, 冨永悌二

    てんかん研究　27　(2)　274-274　2009/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  73. 脳波と脳磁図の所見に乖離が見られた半球性病変によるてんかんの1例

    柿坂庸介, 岩崎真樹, 中里信和, 菅野彰剛, 土屋滋

    てんかん研究　27　(2)　222-223　2009/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  74. 良性ローランドてんかんと予後不良の感覚運動発作を呈するてんかん群では中心溝棘波の信号源局在が異なる

    柿坂庸介, 中里信和, 萩野谷和裕, 菅野彰剛, 土屋滋

    てんかん研究　27　(2)　330-330　2009/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  75. Efficacy of Continuous Acyclovir Infusion in Neonatal Herpes Virus Encephalitis

    Y. Kakisaka, M. Ishitobi, K. Wakusawa, K. Haginoya, N. Togashi, T. Kitamura, N. Hino-Fukuyo, I. Sato, M. Uematsu, S. Tsuchiya

    NEUROPEDIATRICS　40　(4)　199-200　2009/08

    DOI： 10.1055/s-0029-1241187 　

    ISSN： 0174-304X

  76. 脳梁離断による全般性棘波の側性化半球間潜時差の影響

    岩崎真樹, 中里信和, 柿坂庸介, 菅野彰剛, 植松貢, 萩野谷和裕, 冨永悌二

    日本脳神経外科学会総会抄録集(CD-ROM)　68th　ROMBUNNO.1D-O001-04　2009

    ISSN： 1347-9040

  77. 頭痛のない片頭痛と機能性腹痛

    柿坂庸介

    仙台市医師会報　543　41-42　2009

  78. 筋痛を主訴に非典型的な経過をたどりギランバレー症候群亜型と考えられた1例 Peer-reviewed

    佐藤 育子, 佐藤 徹雄, 小野 雅典, 涌澤 圭介, 柿坂 庸介, 船越 慶, 萩野谷 和裕

    小児科臨床　62　(1)　115-118　2009/01

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  79. EPILEPSY OF ROLANDIC SPIKES WITH POSTERIOR CURRENT ORIENTATION

    Yosuke Kakisaka, N. Nakasato, A. Kanno, K. Haginoya, S. Tsuchiya

    EPILEPSIA　49　219-219　2008

    ISSN： 0013-9580

  80. 【神経疾患】 遺伝子診断により診断を確認した重症ミオクロニーてんかん(SME)の2家系3症例

    福與 なおみ, 萩野谷 和裕, 冨樫 紀子, 北村 太郎, 植松 貢, 柿坂 庸介, 石飛 真美子, 涌澤 圭介, 中里 信和, 社本 博, 飯沼 一宇

    小児科臨床　59　(9)　1931-1937　2006/09

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  81. 腸回転異常を伴ったCostello症候群の1例 Peer-reviewed

    柿坂 庸介, 坂本 修, 小島 加奈子, 植松 貢, 松田 直, 大浦 敏博, 土屋 滋, 林 富

    小児科臨床　59　(9)　2057-2061　2006/09

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  82. 四肢麻痺と呼吸困難を呈した胸部交感神経原発乳児神経芽腫の2例 Peer-reviewed

    森川 志穂, 笹原 洋二, 吉成 みやこ, 柿坂 庸介, 小沼 正栄, 坂本 修, 飯沼 一宇, 田中 靖久, 星川 健, 国分 正一, 中村 潤, 林 富, 久間木 悟, 土屋 滋

    小児がん　43　(2)　210-215　2006/09

    Publisher: (NPO)日本小児がん学会

    ISSN： 0389-4525

  83. FDG-pet study of genetically confirmed patients with severe myoclonic epilepsy in infancy

    Kazuhiro Haginoya, Noriko Togashi, Taro Kitamura, Yosuke Kakisaka, Keisuke Wakusawa, Naomi Fukuyo, Mamiko Ishitobi, Kazuie Iinuma, Shigeru Tsuchiya, Kazuhiro Yamakawa

    EPILEPSIA　47　82-83　2006

    ISSN： 0013-9580

  84. Increased blood flow of subcortical structure including basal ganglia/thalamus and brain stem during spasm in west syndrome. 11 cases of west syndrome analyzed with subtraction ictal spect

    Yosuke Kakisaka, Kazuhiro Haginoya, Mamiko Ishitobi, Noriko Togashi, Taro Kitamura, Keisuke Wakusawa, Ikuko Sato, Naomi Fukuyo, Mitsutoshi Munakata, Hiroyuki Yokoyama, Shigeru Tsuchiya, Kazuie Iinuma

    EPILEPSIA　47　84-84　2006

    ISSN： 0013-9580

  85. スパズム発作時の脳血流動態-Subtraction ictal画像によるWest症候群11例の検討

    柿坂庸介, 萩野谷和裕, 石飛真美子, 冨樫紀子, 北村太郎, 涌澤圭介, 佐藤育子, 福與なおみ, 宗形光敏, 横山浩之, 土屋滋, 飯沼一宇

    てんかん研究　24　(3)　232-232　2006

  86. 硫酸マグネシウムを投与されていた母体から出生した先天性くる病の双胎例 Peer-reviewed

    柿坂 庸介, 松木 茂伸, 三浦 雄一郎, 中山 信吾, 佐藤 都留雄, 田名部 宗之, 工藤 正文

    八戸市立市民病院医誌　21　(2)　91-95　2005/02

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

  87. 【精神・神経疾患】 スマトリプタン点鼻液の投与が著効したabdominal migraineと考えられた1例 Peer-reviewed

    柿坂 庸介, 松木 茂伸, 三浦 雄一郎, 中山 信吾, 佐藤 都留雄, 田名部 宗之, 工藤 正文

    小児科臨床　57　(11)　2285-2289　2004/11

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  88. 硫酸マグネシウム投与を受けた母体において胎内で著明な三尖弁逆流を認めた双胎例 Peer-reviewed

    柿坂 庸介, 松木 茂伸, 三浦 雄一郎, 中山 信吾, 佐藤 都留雄, 田名部 宗之, 工藤 正文

    小児科臨床　57　(8)　1875-1880　2004/08

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  89. 血球貪食症候群の4例 Peer-reviewed

    佐藤 智樹, 三浦 雄一郎, 柿坂 庸介, 中山 信吾, 佐藤 都留雄, 田名部 宗之, 工藤 正文

    八戸市立市民病院医誌　21　(1)　18-27　2003/05

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

  90. 診断に苦慮したクローン病の二例 Peer-reviewed

    三浦 雄一郎, 柿坂 庸介, 佐藤 智樹, 中山 信吾, 佐藤 都留雄, 田名部 宗之, 工藤 正文, 木皿 典宏, 澤 直哉

    八戸市立市民病院医誌　21　(1)　28-31　2003/05

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

  91. 極低出生体重児の胆汁うっ滞の2例 Peer-reviewed

    柿坂 庸介, 三浦 雄一郎, 佐藤 智樹, 中山 信吾, 佐藤 都留雄, 田名部 宗之, 工藤 正文

    八戸市立市民病院医誌　21　(1)　36-40　2003/05

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

  92. 溶連菌感染による深部静脈血栓症に対して下大静脈フィルターを使用した一例 Peer-reviewed

    山本 匡, 柿坂 庸介, 遠藤 一靖, 櫻井 薫

    仙台市立病院医学雑誌　23　125-127　2003/05

    Publisher: 仙台市立病院

    ISSN： 0388-8878

  93. 家庭内喫煙の有無と喘息児の臨床経過について Peer-reviewed

    佐藤 都留雄, 三浦 雄一郎, 柿坂 庸介, 佐藤 智樹, 中山 信吾, 田名部 宗之, 工藤 正文

    八戸市立市民病院医誌　21　(1)　41-46　2003/05

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

  94. 腸炎を契機に出血性脳梗塞をきたしたnephrocalcinosisの1例 Peer-reviewed

    柿坂 庸介, 秋保 直樹, 沖津 庸子, 北村 知子, 遠藤 一靖, 佐藤 峰成, 樋口 じゅん, 小川 達次

    仙台市立病院医学雑誌　22　135-139　2002/05

    Publisher: 仙台市立病院

    ISSN： 0388-8878

  95. 甲状腺クリーゼを呈し甲状腺亜全摘後に脳膿瘍を発症した副鼻腔炎の1例 Peer-reviewed

    柿坂 庸介, 山本 匡, 大西 康, 遠藤 一靖, 佐藤 峰成, 樋口 じゅん, 小川 達次, 鈴木 直弘, 沖津 卓二, 高屋 潔, 小沼 武英

    仙台市立病院医学雑誌　22　127-133　2002/05

    Publisher: 仙台市立病院

    ISSN： 0388-8878

  96. 腎不全を原因とするシベンゾリン中毒の2例 Peer-reviewed

    柿坂 庸介, 小田倉 弘典, 滑川 明男, 櫻井 薫, 石田 明彦, 大友 潔, 佐藤 公雄, 林 英守, 伊藤 明一

    仙台市立病院医学雑誌　22　119-125　2002/05

    Publisher: 仙台市立病院

    ISSN： 0388-8878

Show all ︎Show first 5

Books and Other Publications 5

  1. 頭痛とてんかんの関係を教えてください：Q&Aでわかる初心者のための小児のてんかん・けいれん.

    柿坂庸介, 編集)奥村彰久, 白石秀明

    中外医学社，東京　2022

  2. どのような患者に抗てんかん薬が必要なのでしょうか：Q&Aでわかる初心者のための小児のてんかん・けいれん.

    柿坂庸介, (編集)奥村彰久, 白石秀明

    中外医学社，東京　2022

  3. 貧血と好中球減少症、特徴的な骨X線所見を呈した6歳男児.

    柿坂庸介, 福與なおみ

    診断と治療社　2015

  4. MEG in epilepsy care

    Kakisaka Y, Nakasato N

    Igaku shoin　2015

  5. Video EEG monitoring

    Kakisaka Y, Nakasato N

    Igaku shoin　2015

Presentations 101

  1. 動画記録を活用し教員と模擬患者からの複合的フィードバックを導入した医療面接教育の試み

    第25回東北シミュレーション医学医療教育研究会大会　2025/05/17

  2. 医学を学んで、発想を広げて、未来を創ろう

    沖縄進学エンカレッジ推進事業(2022/10~毎年)　2025

  3. てんかん医療における最強人材である精神科医に、どうすれば「てんかん医療」を好きになってもらえるか． Invited

    第119回日本精神神経学会学術総会　2023/06/23

  4. Attempt of changing global epilepsy care with teleeducation. Actions of Tohoku University, and future educational plan for Indonesian epilepsy care by Japan Epilepsy Society (JES). Invited

    Kakisaka Y

    2022/09/21

  5. オンライン医学教育の意義と運用の実際-遠隔てんかん症例検討会の経験から-

    柿坂庸介

    第51回日本臨床神経生理学会　2021/12/17

  6. 試験で出たところから学ぶ小児脳波 - 臨床検査技師国家試験から - Invited

    第9回日本神経生理検査研究会東北支部研修会　2021/09/25

  7. オンライン教育のプレゼンテーションにおける残存効果のある「指マーカー機能」の有用性

    柿坂庸介

    第24回日本遠隔医療学会学術大会　2021/02/11

  8. Tips for writing case report in MEG

    Kakisaka Y

    Tohoku-Yonsei Epilepsy and MEG symposium: toward better presurgical evaluation and surgery　2021/02/19

  9. Teleconference system changes professional education in epilepsy

    Kakisaka Y

    Tohoku-Yonsei Epilepsy and MEG symposium: toward better presurgical evaluation and surgery　2021/02/19

  10. 当科のオンラインを活用したてんかん診療

    柿坂庸介

    第8回全国てんかんセンター協議会　2021/02/13

  11. 脳波を30分で好きになってもらうには

    柿坂庸介

    第50回日本臨床神経生理学会　2020/11/27

  12. てんかん診療における遠隔外来と包括的入院精査の相補的利用

    柿坂庸介

    第50回日本臨床神経生理学会　2020/11/26

  13. てんかん発作のいろいろ

    柿坂 庸介

    第187回四季会　2020/01/25

  14. Education by telemedicine warrants sustainable development. Invited

    Yosuke Kakisaka

    Kickoff meeting of Medical Excellence Japan at Cipto Mangunkusumo Hospital.　2020/01/24

  15. Education by telemedicine warrants sustainable development. Invited

    Yosuke Kakisaka

    Kickoff meeting of Medical Excellence Japan at Kariadi Hospital.　2020/01/23

  16. Education by telemedicine warrants sustainable development. Invited

    Yosuke Kakisaka

    Kickoff meeting of Medical Excellence Japan at Soetomo Hospital.　2020/01/22

  17. Education by telemedicine warrants sustainable development. Invited

    Yosuke Kakisaka

    Kickoff meeting of Medical Excellence Japan at Hasan-Sadikin Hospital　2020/01/21

  18. 遠隔てんかん症例検討会の未来

    柿坂庸介

    第20回東北てんかんフォーラム　2020/01/11

  19. 遠隔てんかん症例検討会

    柿坂庸介

    第23回日本遠隔医療学会学術大会　2019/10/06

  20. 明日から役立つ発作学・脳波学

    柿坂庸介

    Educational seminar 明日から役立つ脳波検査@新潟大　2019/07/11

  21. 片頭痛の小児例:何歳から病歴聴取は可能か

    柿坂庸介

    第5回プライマリケア医のための頭痛フォーラムin宮城　2019/06/27

  22. 遠隔テレビ会議×症例検討会：てんかん診療に大きなインパクト

    柿坂庸介

    Clinic Magazine 6月号　2019/06

  23. てんかん患者100万人(てんかん遠隔症例検討会)

    柿坂庸介

    時事通信2019/4　2019/04

  24. てんかんの医療者教育をオンラインで

    柿坂庸介

    Q Life Pro 2019/4　2019/04

  25. テレビ会議システムを活用した医療者教育とオンライン診療-遠隔てんかん症例検討会の教育的意義を中心に-

    柿坂庸介

    てんかんプレスセミナー　2019/03/22

  26. 明日から役立つ発作学・脳波学

    柿坂庸介

    Educational seminar 明日から役立つ脳波検査@岩手医大　2019/03/06

  27. てんかんの症例検討会に遠隔会議システム活用

    柿坂庸介

    ミクス2019/3　2019/03

  28. てんかん遠隔症例検討会の教育的意義

    柿坂庸介

    第16回てんかん包括医療東北研究会　2018/11/17

  29. 大学病院てんかん科における医学科学生実習カリキュラム

    柿坂庸介

    第52回日本てんかん学会学術集会　2018/10/26

  30. Outpatient clinic and case-based education via a high definition TV conference system International-presentation

    KAKISAKA, Yosuke

    さくらサイエンス　2018/09/10

  31. Our activities with teleconference system International-presentation

    KAKISAKA, Yosuke

    台南市ゼーランディア認知症協会訪問記念講演会　2018/08/31

  32. Outpatient clinic and case-based education via a high definition TV conference system. International-presentation Invited

    KAKISAKA, Yosuke

    12th Asian Oceanian Epilepsy Congress　2018/06/30

  33. てんかん診療における脳磁図の役割と電流双極子モデルの意味 Invited

    柿坂庸介

    第33回日本生体磁気学会　2018/06/16

  34. てんかんについて

    柿坂庸介

    LIXIL株式会社企業内勉強会　2018/04/26

  35. 成長する小児てんかん患者に親・医療者はどのようにあるべきか

    柿坂庸介

    河北新報「健康フェア講演」　2018/03/31

  36. 遠隔テレビ会議システムを用いたてんかん症例検討会 Invited

    柿坂庸介

    第51回日本てんかん学会　2017/11/04

  37. ビデオ脳波モニタリングで学ぶてんかん入門

    柿坂庸介

    神経救急カンファランス　2017/09/19

  38. Case studies International-presentation Invited

    KAKISAKA, Yosuke

    Indonesian Neurological Association and Neurology Department, Hasanuddin University　2017/07/08

  39. Semiology and EEG International-presentation Invited

    KAKISAKA, Yosuke

    EEG Workshop, Neurology Department, Hasanuddin University　2017/07/07

  40. EEG of childhood epilepsy International-presentation Invited

    KAKISAKA, Yosuke

    EEG Workshop, Neurology Department, Hasanuddin University　2017/07/07

  41. How to read EEG International-presentation Invited

    KAKISAKA, Yosuke

    EEG Workshop, Neurology Department, Hasanuddin University　2017/07/07

  42. Learn epilepsy from cases. International-presentation Invited

    KAKISAKA, Yosuke

    The International Seminar "Knowing Epilepsy”, Medical Faculty Alkhairaat University　2017/07/05

  43. レベチラセタムは化学物質化敏症の症状緩和に有効かもしれない

    柿坂庸介

    第26回日本臨床環境医学会学術集会　2017/06/24

  44. Variety of symptoms associated with migraine, a migraine variant and idiopathic stabbing headache International-presentation

    KAKISAKA, Yosuke

    AOCCN 2017 (14th Asian and Oceanian Congress of Child Neurology)　2017/05/13

  45. Establishing a structured program for case writing in pediatric neurology medical education: A preliminary study International-presentation

    KAKISAKA, Yosuke

    AOCCN 2017 (14th Asian and Oceanian Congress of Child Neurology)　2017/05/13

  46. 小児の頭痛〜症状聞き取りのコツと親への対応〜

    柿坂庸介

    頭痛フォーラム2017　2017/02/26

  47. ビデオ脳波モニタリングで学ぶてんかん学入門

    柿坂庸介

    第74回神経救急カンファランス　2016/11/17

  48. 作話を呈した右前頭葉てんかんの２例

    柿坂庸介

    第12回てんかん包括医療東北研究会　2016/11/14

  49. ラスムッセン脳炎

    柿坂庸介

    第50回日本てんかん学会学術集会　2016/10/08

  50. MEG may reveal hidden population of spikes in epilepsy with porencephalic cyst/encephalomalacia International-presentation

    KAKISAKA, Yosuke

    20th International Conference on Biomagnetism (BIOMAG2016)　2016/10/06

  51. 脳磁図は様々な領域の棘波を捉える Invited

    柿坂庸介

    第31回日本生体磁気学会　2016/06/10

  52. 医学生に対する小児神経領域の症例報告指導の経験〜要改善点の抽出と執筆プログラム開発の試み〜

    柿坂庸介

    第58回日本小児神経学会　2016/06/03

  53. てんかん診療における脳磁図の可能性を考える Invited

    柿坂庸介

    第39回日本脳神経CI学会　2016/01/29

  54. 左手のtwitchingを呈したEPCにおいて脳波脳磁図所見に乖離が見られた一例(抄録タイトル)

    柿坂庸介

    第49回日本てんかん学会学術集会　2015/10/31

  55. A case of brain herniation into dural venous sinuses

    柿坂庸介

    東北大学病院リハビリテーション科Case of the week　2015/10/20

  56. A case of brain herniation into dural venous sinuses

    柿坂庸介

    宮城放射線カンファランス　2015/10/16

  57. 遠隔てんかん症例検討会デモンストレーション

    柿坂庸介

    第19回日本遠隔医療学会学術大会　2015/10/09

  58. Eye symptoms and epileptic spasms in West syndrome.

    KAKISAKA, Yosuke

    The 57th Congress of Japan Society of Child Neurology　2015/05/30

  59. てんかんとともに成長する~患児に対する教育について~ Invited

    柿坂庸介

    第56回日本神経学会学術大会　2015/05/23

  60. 人とチームをはぐくむてんかん医療-東北大学てんかん科の試み-

    柿坂庸介

    第1回埼玉てんかん懇話会　2015/02/06

  61. てんかんの診断と脳波・発作兆候

    柿坂庸介

    第38回日本てんかん外科学会　2015/01/16

  62. 小児頭痛に随伴する症状の多様性とその診断的有用性に関する研究 Invited

    柿坂庸介

    第38回荒川記念賞受賞特別講演　2014/11/08

  63. 胸部不快感と自律神経症状を呈した自閉症スペクトラムの14歳男児

    柿坂庸介

    日本臨床神経生理学会学術大会　2014/10/16

  64. 側頭葉てんかんが疑われていた腹部片頭痛の一例

    柿坂庸介

    第9回東北てんかんフォーラム　2014/07/12

  65. 小児の片頭痛・片頭痛類縁疾患・穿刺様頭痛の臨床症状の多様性

    柿坂庸介

    第56回小児神経学会学術集会　2014/05/30

  66. 小児の片頭痛・その類縁疾患および穿刺様頭痛の臨床症状の多様性

    柿坂庸介

    第56回日本小児神経学会　2014/05/30

  67. 脳磁図の“眼”でみるてんかんの病態生理

    柿坂庸介

    第29回日本生体磁気学会　2014/05/29

  68. 進路決定に臨む皆さんへ

    柿坂庸介

    医学部医学科を目指す生徒のために：仙台青陵中等教育学校特別講演　2014/01/31

  69. 周期的な腹痛を認めた片頭痛を有する女性の一例

    柿坂庸介

    東北大学病院リハビリテーション科Case of the weekカンファランス　2013/12/10

  70. てんかん患者の被災直後の実態調査に基づいた災害に強い診療システムの提案

    柿坂庸介

    第45回記念精神神経系薬物治療研究報告会　2013/12/06

  71. バルプロ酸による非対称性振戦を認めた小児例

    柿坂庸介

    第47回日本てんかん学会　2013/10/12

  72. 症例報告を書こう

    東北大学小児科研修医会　2013/08/03

  73. ある共働き医者夫婦の日常

    柿坂庸介

    宮城県医師会女性医師支援セミナー　2013/06/15

  74. Unique magnetoencephalography interictal spikes and seizure onset: known and unknown advantages.

    KAKISAKA, Yosuke

    The 55th Congress of Japan Society of Child Neurology　2013/05/29

  75. Magnetoencephalography in Fronto-Parietal Operculum

    The 46th Congress of Japan Epilepsy Society　2012/10

  76. 発作時スパズムを脳磁図で捉え得た2例

    東北小児神経懇話会　2012/09

  77. 症例報告の書き方の一方法論

    東北小児神経懇話会　2012/09

  78. 乳児Tullio現象

    東北大学小児科優秀論文賞記念講演　2012/02

  79. 前頭頭頂葉弁蓋部由来のてんかんにおける脳磁図の有用性

    東北大学小児科優秀論文賞記念講演　2012/02

  80. Use of simultaneous depth and MEG recording to provide complementary information regarding the epileptogenic region. International-presentation

    The Cleveland Clinic Neurological Institute Research Day 2011　2011/05/26

  81. Utility of tsss algorithm in SEF in Patients with VNS. International-presentation

    The Cleveland Clinic Neurological Institute Ground Round　2011/05/20

  82. Generalized 3 Hz spike-and-wave complexes emanating from focal epileptic activity in pediatric patients. International-presentation

    The 64th North American Epilepsy Congress　2010/12/05

  83. 小児期に発症する感覚運動発作で良性ローランドてんかんと予後不良の感覚運動発作を呈するてんかん群の信号源局在の差異に関する検討

    第43回日本臨床神経生理学会　2009/11

  84. Somatotopic location of rolandic spikes in pediatric-onset epilepsy with sensorimotor seizures International-presentation

    2nd Conference of International Society for the Advancement of Clinical Magnetoencephalography　2009/09/03

  85. 笑い発作を呈した前頭葉てんかんの一例

    第3回日本てんかん学会東北地方会　2009/07

  86. Sensorimotor seizures of pediatric onset with unusual posteriorly-oriented rolandic spikes. International-presentation

    The 62th North American Epilepsy Congress　2008/12

  87. 突発波の電流方向が後ろ向きの小児期発症ローランド発作を有するてんかんの臨床像

    第14回日本小児神経学会東北地方会　2008/11

  88. 小児期発症の感覚運動発作を呈し電流方向が後ろ向きのてんかんの臨床像

    第42回日本てんかん学会　2008/10

  89. Seizure semiology and outcome in patients with rolandic discharges of posterior dipole orientation International-presentation

    International Conference on Biomagnetism　2008/08

  90. 電流方向が後ろ向きのローランドてんかんの4例

    第10回日本ヒト脳機能マッピング学会　2008/06

  91. 電流方向が後ろ向きのローランドてんかんの臨床像

    日本生体磁気学会　2008/06

  92. 器質病変の対側に棘波が目立った一例

    第41回日本てんかん学会　2007/10

  93. Development of contralateral spike focus over years in a patient with cavernoma and medically intractable epilepsy International-presentation

    1st Conference of International Society for the Advancement of Clinical Magnetoencephalography　2007/08

  94. 出生直後より特徴的症状を呈した脳幹網様体反射ミオクローヌスと考えられる一例

    第48回日本小児神経学会　2007/07

  95. Activation of subcortical gray matter during spasms in patients with West syndrome: Subtraction SPECT. International-presentation

    The 10th Annual meeting of the infantile seizure society　2007/04

  96. Increased blood flow of subcortical structure including basal ganglia and thalamus during spasm in West syndrome. 11 cases of West syndrome analyzed with subtraction ictal SPECT. International-presentation

    The 60th North American Epilepsy Congress　2006/12/06

  97. Neonatal rigid-akinetic syndromeの1例

    第136回東北小児神経学研究会　2006/09

  98. West症候群におけるスパズム時の脳血流動態〜Subtraction ictal SPECTを用いて〜

    第40回日本てんかん学会　2006/09

  99. 四肢麻痺、頚部痛で発症したCraniovertebral neurenteric cystの一例

    第47回日本小児神経学会　2006/06

  100. タクロリムスが有効であった難治性眼筋咽頭型重症筋無力症の1例

    第11回東北小児神経地方会　2005/11

  101. Subtraction ictal SPECTを用いたWest症候群を含むてんかん23例の検討

    第46回日本小児神経学会　2005/05

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Research Projects 5

  1. Elucidation of a mechanism of epileptic seizure induction by using multimodal autonomic monitoring

    Jin Kazutaka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    Multimodal autonomic monitoring system including electrogastrography as well as electroencephalography, electrocardiography, and oxygen saturation was established in the present study. Unfortunately, no seizures were detected during simultaneous recording of electrogastrography and a mechanism of epileptic seizure induction has not been elucidated. However, interesting data of interictal heart rate variability during non-REM sleep, postictal asystole, preictal central apnea was obtained from simultaneous monitoring of heart rate and respiration with electroencephalography in the present study.

  2. Visualization of dynamic brain function by magnetoencephalography using tunnel magnetic resistance (TMR) sensors

    Nakasato Nobukazu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    In the present study, we successfully measured magnetocardiography (MCG) using tunnel-magnetic-resistance (TMR) sensors without signal averaging technique. We also successfully measured magnetoencephalography (MEG) using TMR sensors for the first. In order to expand MEG application, we applied conventional SQUID MEG to reveal neuronal mechanism of “lip-reading”. We also applied MEG to measure somatosensory evoked magnetic fields (SEFs) with strict separation of awake and sleep condition. As a result, we found amplitude of N20m, the first component of SEFs, is decreased during awake condition only in patients with temporal lobe epilepsy. Using intracranial electrode, we also found high frequency oscillation during rapid-eye-movement (REM) sleep is specific to epileptogenic area. Above all results, we became more confident for the development of TMR MEG system in the future.

  3. 遠隔ネットワークを用いた医学生に対する症例報告執筆プログラムの確立 Competitive

    柿坂庸介

    Offer Organization: 日本学術振興会

    System: 科研費

    2015/04 - 2018/03

  4. Development of pediatric MEG measurement without sedation

    NAKASATO Nobukazu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2013/04/01 - 2015/03/31

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    We applied superconducting quantum interference device (SQUID)-based magnetoencephalography (MEG) to measure both normal brain function and epilepsy-related abnormal activity for future development of tunnel-magnetic-registance (TMR)-based high resolution MEG system. Subjects were people with epilepsy with focal cortical dysplasia, with various types of age-dependent epilepsy, or with interhemispheric foci; and normal subjects. Time-axis waveformes and sensor-based isofield maps were analyzed for both epileptic and normal auditory function. These basic data can be used to apply future development of high-resolution MEG system using TMR sensors.

  5. 高密度脳波及び脳磁図で加算平均法を用いたウエスト症候群の発作焦点同定に関する研究 Competitive

    柿坂庸介

    Offer Organization: 日本学術振興会

    System: 科研費

    2013/04 - 2015/03

Teaching Experience 8

  1. 全学総合科目「体と健康」　東北大学経済学部

  2. 全学総合科目「健康と医学」　東北大学

  3. 基礎ゼミ　東北大学

  4. 臨床実習(てんかん学)　東北大学医学部医学科

  5. 小児脳波学　東北大学医学部保健学科

  6. 画像診断学　東北大学医学部医学科

  7. 臨床薬理学　東北大学医学部医学科

  8. 「症例報告の書き方」講義　東北大学医学部医学科, 東北医科薬科大学医学部医学科

Show all Show first 5

Social Activities 4

  1. 沖縄県 進学エンカレッジ推進事業

    2022/10 - Present

  2. てんかんとは

    LIXIL株式会社企業内勉強会

    2018/04/26 - 2018/04/26

  3. 成長する小児てんかん患者に親・医療者はどのようにあるべきか

    健康フェア

    2018/03/31 - 2018/03/31

  4. 進路決定に望む皆さんへ

    2014/01/31 - 2014/01/31

Media Coverage 5

  1. 高校生に対する模擬講義の経験を通じて(艮陵新聞；東北大学医学部新聞)

    2024/02

  2. 遠隔テレビ会議×症例検討会：てんかん診療に大きなインパクト

    Clinic Magazine 6月号

    2019/06

  3. 記事：てんかん患者100万人(てんかん遠隔症例検討会)

    時事通信2019/4/21掲載

    2019/04

  4. 記事：てんかんの症例検討会に遠隔会議システム活用

    ミクス2019/3/25掲載

    2019/03

  5. 記事：てんかんの医療者教育をオンラインで

    Q Life Pro 2019/4/3掲載

    2019/03

Other 1

  1. 各種講義動画（てんかん学・症例報告法・医学教育など）

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    www.youtube.com/@柿坂庸介