Details of the Researcher

PHOTO

Hideki Kitaura
Section
Graduate School of Dentistry
Job title
Associate Professor
Degree

  • 博士（歯学）（長崎大学）

Research History 1

  • 2013/02 - Present
    Tohoku University　Graduate School of Dentistry

Education 2

  • Nagasaki University　Graduate School, Division of Dental Research　Orthodontics

    - 1994/03/31

  • Nagasaki University　Faculty of Dentistry

    - 1991/03/31

Committee Memberships 3

  • 東北矯正歯科学会　評議員

    - Present

  • 東北矯正歯科学会　理事

    - Present

  • 日本矯正歯科学会　代議員

    - Present

Research Interests 7

  • 肥満

  • 高血圧

  • 糖尿病

  • 骨細胞

  • 破骨細胞

  • 骨代謝

  • Orthodontics

Research Areas 1

  • Life sciences / Developmental dentistry /

Awards 21

  1. 第26回日本矯正歯科学会学術奨励賞

    2023/11　日本矯正歯科学会　Micro-osteoperforations induce TNF-α expression and accelerate orthodontic tooth movement via TNF-α-responsive stromal cells

  2. 第82回日本矯正歯科学会学術大会優秀発表賞

    2023/11　日本矯正歯科学会　ネクロプトーシスした骨細胞が矯正学的歯の移動に伴う破骨細胞形成に与える影響

  3. The 82nd Annual Meeting of the Japanese Orthodontic Society.

    2023/11　Japanese Orthodontic Society　Analysis of DHA effects on osteoclastogenesis through GPR120 in a bone marrow chimeric mouse model.

  4. American Society for Bone and Mineral Research 2023 Annual Meeting, Plenary Poster

    2023/10　The American Society for Bone and Mineral Research　Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and bone resorption through GPR120.

  5. ASBMR Pre-Meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells, Travel award

    2023/10　The American Society for Bone and Mineral Research　Hyperglycemia induces extensive alternative splicing changes in osteocytes with minimal transcriptional alterations.

  6. ASBMR Pre-Meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells, Travel award

    2023/10　The American Society for Bone and Mineral Research　Effect of DAMPs released from osteocyte necroptosis on osteoclastogenesis.

  7. ASBMR Pre-Meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells, Travel award

    2023/10　The American Society for Bone and Mineral Research　Azilsartan inhibits inflammation-triggered bone resorption and osteoclastogenesis in vivo via suppression of TNF-α expression in macrophages.

  8. 第81回日本矯正歯科学会学術大会優秀発表賞

    2022/10　日本矯正歯科学会　TNF-αの骨細胞における破骨細胞分化関連遺伝子発現のRNAシーケンス

  9. 第81回日本矯正歯科学会学術大会優秀発表賞

    2022/10　日本矯正歯科学会　キメラマウスを用いた矯正学的歯の移動促進のマイクロオステオパーフォレーションの解析

  10. 第80回日本矯正歯科学会学術大会優秀発表賞

    2021/11　日本矯正歯科学会　矯正学的歯の移動における骨細胞のネクロプトーシスの検出

  11. The 9th IOC Residents Forum Award 2nd Prize

    2020/10

  12. NIH-Japan-JSPS Symposium Travel award

    2019/10

  13. American Society for Bone and Mineral Research 2019 Annual Meeting Travel grant

    2019/09

  14. 第40回東北骨代謝・骨粗鬆症研究会 基礎部門 優秀演題賞

    2019/02

  15. The 77th Annual Meeting of the Japanese Orthodontic Society Excellent presentation award

    2018/10

  16. 第75回矯正歯科学会学術大会優秀発表賞

    2016/11　日本矯正歯科学会　矯正学的歯の移動における破歯細胞形成および歯根吸収へのTNF-αの関与について

  17. 第37回東北骨代謝・骨粗鬆症研究会 基礎部門 優秀演題賞

    2016/02

  18. 東北大学歯学会学術賞

    2015/06　東北大学

  19. The 5th International Symposium for Interface Oral Health Science Excellent Poster Presentation Award

    2014/01

  20. 第71回日本矯正歯科学会学術大会優秀発表賞

    2007/10

  21. 第66回日本矯正歯科学会優秀発表賞

    2007/10

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Papers 180

  1. Exacerbating orthodontic tooth movement in mice with salt-sensitive hypertension. International-journal

    Ziqiu Fan, Hideki Kitaura, Takahiro Noguchi, Fumitoshi Ohori, Aseel Marahleh, Jinghan Ma, Jiayi Ren, Angyi Lin, Kohei Narita, Itaru Mizoguchi

    Journal of dental sciences　20　(2)　764-769　2025/04

    DOI： 10.1016/j.jds.2024.10.020 　

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    BACKGROUND/PURPOSE: Orthodontic tooth movement (OTM) is a critical aspect of dental treatment that requires the precise control of bone remodeling processes. Hypertension (HTN) can affect the effectiveness of OTM. Salt-sensitive hypertension (SSHTN) is of particular concern due to its detrimental effects on bone health, potentially altering orthodontic outcomes. This study aimed to investigate the effects of SSHTN on OTM using a mouse model. MATERIALS AND METHODS: Male mice were divided into a normal and an SSHTN group. The SSHTN model was generated by administering N(ω)-nitro-l-arginine methyl ester (l-NAME) followed by a high-salt diet. The OTM was performed using a nickel-titanium (Ni-Ti) closed-coil spring, and the tooth movement was measured after 12 days. Silicone imprinting was used to estimate the OTM distance. Osteoclast activity was assessed using tartrate-resistant acid phosphatase (TRAP) staining of decalcified maxillary sections. RESULTS: SSHTN mice exhibited significantly increased tooth movement compared to normal mice. This enhanced movement was associated with more osteoclasts in the SSHTN group than in the control group. These findings suggest that SSHTN increases OTM levels by promoting bone resorption. CONCLUSION: SSHTN significantly affected OTM by enhancing osteoclast activity and increasing tooth movement. These results underscore the importance of considering hypertensive conditions in orthodontic treatment planning as they may require adjustments in force application to prevent potential adverse effects.

  2. Angiotensin II Promotes Osteocyte RANKL Expression via AT1R Activation. International-journal

    Jiayi Ren, Aseel Marahleh, Jinghan Ma, Fumitoshi Ohori, Takahiro Noguchi, Ziqiu Fan, Jin Hu, Kohei Narita, Angyi Lin, Hideki Kitaura

    Biomedicines　13　(2)　2025/02/10

    DOI： 10.3390/biomedicines13020426 　

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    Background/Objective: Osteocytes are the most abundant cell type in the skeleton, with key endocrine functions, particularly in regulating osteoblast and osteoclast activity to maintain bone quality. Angiotensin II (Ang II), a critical component of the renin-angiotensin-aldosterone system, is well-known for its role in vasoconstriction during hypertension. Beyond its cardiovascular functions, Ang II participates in various biological processes, including bone metabolism. While its influence on osteoblast proliferation, differentiation, and osteoclastogenesis has been documented, its effects on osteocytes remain unexplored. This study hypothesized that Ang II enhances the osteoclastogenic activity of osteocytes. Methods: Mouse calvariae were cultured ex vivo in an Ang II-containing medium, analyzed via immunohistochemistry, and evaluated for osteoclastogenic gene expression through real-time PCR. Western blotting was employed to assess protein levels and signaling pathway activation in the MLO-Y4 osteocytic cell line in vitro. Results: Ang II significantly increased the expression of receptor activator of nuclear factor κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). These effects were abrogated by azilsartan, a blocker targeting Ang II type 1 receptors (AT1R). p38 and ERK1/2 in the MAPK pathway were also activated by Ang II. Conclusions: Ang II enhances osteocyte-mediated osteoclastogenesis via AT1R activation, highlighting its potential as a therapeutic target for bone diseases.

  3. Role of CXCL10 released from osteocytes in response to TNF-α stimulation on osteoclasts. International-journal

    Mariko Miura, Hideki Kitaura, Fumitoshi Ohori, Kohei Narita, Jiayi Ren, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Angyi Lin, Ziqiu Fan, Itaru Mizoguchi

    Scientific reports　15　(1)　3040-3040　2025/01/24

    DOI： 10.1038/s41598-025-87092-7 　

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    Tumor necrosis factor-alpha (TNF-α) is a significant cytokine that regulates bone resorption under inflammatory conditions. However, its mechanism of action in osteocytes remains unclear. In this study, highly purified osteocytes were isolated from dentin matrix protein 1 (DMP1)-Topaz mice using cell sorter. RNA sequencing (RNA-seq) revealed that TNF-α stimulation increased C-X-C motif chemokine ligand 10 (CXCL10) gene expression in osteocytes. Although CXCL10 did not affect osteoclast differentiation in vitro, it enhanced the migration of osteoclast precursors. Additionally, in the transwell co-culture system, TNF-α induced the migration of osteoclast precursors. However, this effect was attenuated by a CXCL10-neutralizing antibody. In vivo, mice were administered supracalvarial injections of TNF-α with or without the CXCL10-neutralizing antibody for 5 days. The percentage of CXCL10-positive osteocytes increased after TNF-α administration. Additionally, osteoclast formation and bone resorption were assessed. CXCL10-neutralizing antibody-treated calvariae exhibited a significantly lower number of osteoclasts and bone resorption than those treated with TNF-α alone. These results indicated that TNF-α-induced CXCL10, which affects the migration of osteocyte-derived osteoclast precursors, may enhance TNF-α-triggered osteoclast formation and bone resorption in vivo.

  4. Exogenous Angiotensin-(1-7) Provides Protection Against Inflammatory Bone Resorption and Osteoclastogenesis by Inhibition of TNF-α Expression in Macrophages. International-journal

    Jiayi Ren, Hideki Kitaura, Takahiro Noguchi, Fumitoshi Ohori, Aseel Marahleh, Jinghan Ma, Kayoko Kanou, Ziqiu Fan, Itaru Mizoguchi

    Calcified tissue international　115　(4)　432-444　2024/10

    DOI： 10.1007/s00223-024-01257-6 　

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    Renin-angiotensin-aldosterone system plays a crucial role in the regulation of blood pressure and fluid homeostasis. It is reported to be involved in mediating osteoclastogenesis and bone loss in diseases of inflammatory bone resorption such as osteoporosis. Angiotensin-(1-7), a product of Angiotensin I and II (Ang I, II), is cleaved by Angiotensin-converting enzyme 2 and then binds to Mas receptor to counteract inflammatory effects produced by Ang II. However, the mechanism by which Ang-(1-7) reduces bone resorption remains unclear. Therefore, we aim to elucidate the effects of Ang-(1-7) on lipopolysaccharide (LPS)-induced osteoclastogenesis. In vivo, mice were supracalvarial injected with Ang-(1-7) or LPS ± Ang-(1-7) subcutaneously. Bone resorption and osteoclast formation were compared using micro-computed tomography, tartrate-resistant acid phosphatase (TRAP) stain, and real-time PCR. We found that Ang-(1-7) attenuated tumor necrosis factor (TNF)-α, TRAP, and Cathepsin K expression from calvaria and decreased osteoclast number along with bone resorption at the suture mesenchyme. In vitro, RANKL/TNF-α ± Ang-(1-7) was added to cultures of bone marrow-derived macrophages (BMMs) and osteoclast formation was measured via TRAP staining. The effect of Ang-(1-7) on LPS-induced osteoblasts RANKL expression and peritoneal macrophages TNF-α expression was also investigated. The effect of Ang-(1-7) on the MAPK and NF-κB pathway was studied by Western blotting. As a result, Ang-(1-7) reduced LPS-stimulated macrophages TNF-α expression and inhibited the MAPK and NF-κB pathway activation. However, Ang-(1-7) did not affect osteoclastogenesis induced by RANKL/TNF-α nor reduce osteoblasts RANKL expression in vitro. In conclusion, Ang-(1-7) alleviated LPS-induced osteoclastogenesis and bone resorption in vivo via inhibiting TNF-α expression in macrophages.

  5. Three-Dimensional Evaluation of Treatment Effects and Post-Treatment Stability of Maxillary Molar Intrusion Using Temporary Anchorage Devices in Open Bite Malocclusion Peer-reviewed

    Hiroki Ogura, Kento Numazaki, Toshihito Oyanagi, Masahiro Seiryu, Arata Ito, Takahiro Noguchi, Fumitoshi Ohori, Michiko Yoshida, Tomohiro Fukunaga, Hideki Kitaura, Itaru Mizoguchi

    Journal of Clinical Medicine　13　(10)　2753-2753　2024/05/07

    Publisher: MDPI AG

    DOI： 10.3390/jcm13102753 　

    eISSN： 2077-0383

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    Background: We investigated treatment outcomes and post-treatment stability in 10 patients with an anterior open bite and nonsurgical orthodontics. Methods: The patients underwent maxillary molar intrusion using temporary anchorage devices (TADs) to deepen the overbite due to mandibular autorotation. Lateral cephalograms and dental cast models were obtained before treatment (T0), immediately after it (T1), and >1 year after it (T2). Skeletal and dental cephalometric changes and three-dimensional movements of the maxillary dentitions were evaluated. Results: At T0, cephalometric analysis indicated that patients had skeletal class I with tendencies for a class II jaw relationship and a skeletal open bite. During active treatment (T0 to T1), the maxillary first molar intruded by 1.6 mm, the mandibular first molar extruded by 0.3 mm, the Frankfort-mandibular plane angle decreased by 1.1°, and the overbite increased by 4.1 mm. Statistically significant changes were observed in the amount of vertical movement of the maxillary first molar, Frankfort-mandibular plane angle, and overbite. Three-dimensional (3D) dental cast analysis revealed that the maxillary first and second molars intruded, whereas the anterior teeth extruded, with the second premolar as an infection point. In addition, the maxillary molar was tipped distally by 2.9° and rotated distally by 0.91°. Statistically significant changes were observed in the amount of vertical movement of the central incisor, lateral incisor, canine and first molar, and molar angulation. From T1 to T2, no significant changes in cephalometric measurements or the 3D position of the maxillary dentition were observed. The maxillary and mandibular dentitions did not significantly change during post-treatment follow-up. Conclusions: Maxillary molar intrusion using mini-screws is an effective treatment for open bite correction, with the achieved occlusion demonstrating 3D stability at least 1 year after treatment.

  6. Effect of age on orthodontic tooth movement in mice. International-journal Peer-reviewed

    Kayoko Kanou, Hideki Kitaura, Takahiro Noguchi, Fumitoshi Ohori, Aseel Marahleh, Ria Kinjo, Jinghan Ma, Jiayi Ren, Kouetsu Ogasawara, Itaru Mizoguchi

    Journal of dental sciences　19　(2)　828-836　2024/04

    DOI： 10.1016/j.jds.2023.09.016 　

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    BACKGROUND/PURPOSE: The number of middle-aged and elderly orthodontic patients is increasing due to changes in age composition. It is important to investigate the detailed mechanisms of bone remodeling in orthodontic tooth movement (OTM) in the elderly. However, there are few reports on the mechanism of tooth movement in the elderly. The purpose of the present study was to analyze OTM and osteoclastogenesis in aged mice and to elucidate the mechanism. MATERIALS AND METHODS: It has been reported that tumor necrosis factor (TNF)-α plays an important role in osteoclast formation and OTM. First, 8-week-old and 78-week-old male C57BL/6J mice were subcutaneously injected with TNF-α into the calvaiae, and micro-CT, tartrate-resistant acid phosphatase (TRAP) staining, and real-time PCR were performed to evaluate osteoclast formation and bone resorption. Furthermore, osteoclastogenesis by TNF-α and receptor activator of nuclear factor-kappa B ligand (RANKL) using bone marrow cells was evaluated in vitro. Finally, a nickel-titanium closed-coil spring was attached, mesial movement of the maxillary left first molar was performed, and tooth movement distance and osteoclast formation were evaluated. RESULTS: Compared to 8-week-old mice, 78-week-old mice had decreased TNF-α-induced bone resorption, osteoclastogenesis, and TRAP and cathepsin K expression in the calvariae. In vitro osteoclast formation also decreased in 78-week-old mice. Furthermore, tooth movement distance and osteoclastogenesis were reduced. CONCLUSION: OTM decreased in aged mice, which was shown to be caused by a decrease in osteoclastogenesis. Therefore, it was suggested that it is necessary to keep in mind that tooth movement may be suppressed when treating elderly patients.

  7. (D-Ala2)GIP Inhibits Inflammatory Bone Resorption by Suppressing TNF-α and RANKL Expression and Directly Impeding Osteoclast Formation Peer-reviewed

    Angyi Lin, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Jiayi Ren, Mariko Miura, Ziqiu Fan, Kohei Narita, Itaru Mizoguchi

    International Journal of Molecular Sciences　25　(5)　2555-2555　2024/02/22

    Publisher: MDPI AG

    DOI： 10.3390/ijms25052555 　

    eISSN： 1422-0067

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    Glucose-insulinotropic polypeptide (GIP) is an incretin hormone that induces insulin secretion and decreases blood glucose levels. In addition, it has been reported to suppress osteoclast formation. Native GIP is rapidly degraded by dipeptidyl peptidase-4 (DPP-4). (D-Ala2)GIP is a newly developed GIP analog that demonstrates enhanced resistance to DPP-4. This study aimed to evaluate the influence of (D-Ala2)GIP on osteoclast formation and bone resorption during lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro. In vivo, mice received supracalvarial injections of LPS with or without (D-Ala2)GIP for 5 days. Osteoclast formation and bone resorption were evaluated, and TNF-α and RANKL expression were measured. In vitro, the influence of (D-Ala2)GIP on RANKL- and TNF-α-induced osteoclastogenesis, LPS-triggered TNF-α expression in macrophages, and RANKL expression in osteoblasts were examined. Compared to the LPS-only group, calvariae co-administered LPS and (D-Ala2)GIP led to less osteoclast formation, lower bone resorption, and decreased TNF-α and RANKL expression. (D-Ala2)GIP inhibited osteoclastogenesis induced by RANKL and TNF-α and downregulated TNF-α expression in macrophages and RANKL expression in osteoblasts in vitro. Furthermore, (D-Ala2)GIP suppressed the MAPK signaling pathway. The results suggest that (D-Ala2)GIP dampened LPS-triggered osteoclast formation and bone resorption in vivo by reducing TNF-α and RANKL expression and directly inhibiting osteoclastogenesis.

  8. Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption. International-journal Peer-reviewed

    Jinghan Ma, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Ria Kinjo, Kayoko Kanou, Jiayi Ren, Mariko Miura, Kohei Narita, Itaru Mizoguchi

    International journal of molecular sciences　24　(23)　2023/11/30

    DOI： 10.3390/ijms242317000 　

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    Docosahexaenoic acid (DHA) is an omega-3 fatty acid that exerts physiological effects via G protein-coupled receptor 120 (GPR120). In our previous studies, we figured out the inhibitory effects of DHA on TNF-α (Tumor necrosis factor-α)-induced osteoclastogenesis via GPR120 in vivo. Moreover, DHA directly suppressed RANKL expression in osteoblasts via GPR120 in vitro. In this study, we generated bone marrow chimeric mice using GPR120 deficient mice (GPR120-KO) to study the inhibitory effects of DHA on bone resorption and osteoclast formation. Bone marrow cells of wild-type (WT) or GPR120-KO mice were transplanted into irradiated recipient mice, which were WT or GPR120 deficient mice. The resulting chimeric mice contained stromal cells from the recipient and bone marrow cells, including osteoclast precursors, from the donor. These chimeric mice were used to perform a series of histological and microfocus computed tomography (micro-CT) analyses after TNF-α injection for induction of osteoclast formation with or without DHA. Osteoclast number and bone resorption were found to be significantly increased in chimeric mice, which did not express GPR120 in stromal cells, compared to chimeric mice, which expressed GPR120 in stromal cells. DHA was also found to suppress specific signaling pathways. We summarized that DHA suppressed TNF-α-induced stromal-dependent osteoclast formation and bone resorption via GPR120.

  9. CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress Peer-reviewed

    Yu Yamamoto*, Chiharu Fujihara*, Teerachate Nantakeeratipa, Masahiro Matsumoto, Takahiro Noguchi, Masae Kitagawa, Satoru Yamada, Takashi Takata, Hideki Kitaura, Shinya Murakami

    Journal of Periodontal Research　in press　13182　2023/09

    DOI： 10.1111/jre.13182 　

  10. Three-dimensional morphologic analysis of the maxillary alveolar bone after anterior tooth retraction with temporary anchorage devices Peer-reviewed

    Arata Ito, Atsushi Mayama, Toshihito Oyanagi, Hiroki Ogura, Masahiro Seiryu, Tomohiro Fukunaga, Hideki Kitaura, Itaru Mizoguchi

    The Angle Orthodontist　93　(6)　667-674　2023/07/17

    Publisher: The Angle Orthodontist (EH Angle Education & Research Foundation)

    DOI： 10.2319/120122-827.1 　

    ISSN： 0003-3219

    eISSN： 1945-7103

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    ABSTRACT Objectives To investigate three-dimensional (3D) morphologic changes in the alveolar bone around the maxillary central incisors of patients who underwent premolar extraction and subsequent anterior tooth retraction using temporary anchorage devices (TADs). Materials and Methods The subjects consisted of 16 patients with bimaxillary protrusion. The maxillary anterior teeth were retracted using sliding or loop mechanics and TADs for anchorage reinforcement. Cephalograms and computed tomography scans taken pretreatment and posttreatment were registered with respect to the palatal structures. The movement of the maxillary central incisors and morphologic changes in the anterior alveolar bone were evaluated quantitatively. Results Displacement in the palatal direction was observed in the alveolar bone around the incisors and the interdental septum. The displacement and bone remodeling/tooth movement ratio were larger on the labial side than the palatal side, and decreased progressively from the crest to apex level. The bone thickness was significantly increased on the labial side and decreased on the palatal side. Conclusions Regional differences exist in morphologic changes of the alveolar bone during anterior tooth retraction using TADs. Attention should be paid to the crest region of the palatal alveolar bone because of its small original thickness and low remodeling activity.

  11. Fermented Rice Bran Supplementation Inhibits LPS-Induced Osteoclast Formation and Bone Resorption in Mice. International-journal Peer-reviewed

    Takahiro Noguchi, Hideki Kitaura, Aseel Marahleh, Afifah Zahra Agista, Yusuke Ohsaki, Hitoshi Shirakawa, Itaru Mizoguchi

    Nutrients　15　(13)　2023/07/05

    DOI： 10.3390/nu15133044 　

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    Fermented rice bran (FRB) is known to have numerous beneficial bioactivities, amongst which is its anti-inflammatory properties when used as a supplement. To determine its effects, we examined osteoclastogenesis and bone resorption caused by injections of lipopolysaccharide (LPS), using mice with and without FRB supplementation. The results were favorable: those that received FRB showed reduced osteoclast numbers and bone resorption compared to those with the control diet. Notably, receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-α (TNF-α) mRNA levels were shown to be lower in the LPS-treated animals with FRB supplementation. FRB's inhibitory effect on RANKL- and TNF-α-induced osteoclastogenesis was further confirmed in vitro. In culture, macrophages exhibited decreased TNF-α mRNA levels when treated with FRB extract and LPS versus treatment with LPS alone, but there was no significant change in RANKL levels in osteoblasts. We can conclude that FRB supplementation dampens the effect of LPS-induced osteoclastogenesis and bone resorption by controlling TNF-α expression in macrophages and the direct inhibition of osteoclast formation.

  12. Azilsartan inhibits inflammation-triggered bone resorption and osteoclastogenesis in vivo via suppression of TNF-α expression in macrophages. International-journal Peer-reviewed

    Ziqiu Fan, Hideki Kitaura, Jiayi Ren, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Kayoko Kanou, Mariko Miura, Kohei Narita, Angyi Lin, Itaru Mizoguchi

    Frontiers in endocrinology　14　1207502-1207502　2023

    DOI： 10.3389/fendo.2023.1207502 　

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    INTRODUCTION: Hypertension is a major risk factor for cardiovascular disease (CVD) and is associated with increased bone loss due to excessive activity of the local renin-angiotensin system (RAS). Angiotensinogen/Angiotensin (ANG) II/Angiotensin II type 1 receptor (AT1R) axis is considered as the core axis regulating RAS activity. Azilsartan is an FDA-approved selective AT1R antagonist that is used to treat hypertension. This study aimed to determine whether azilsartan affects formation of osteoclast, resorption of bone, and the expression of cytokines linked with osteoclastogenesis during lipopolysaccharide (LPS)-triggered inflammation in vivo. METHODS: In vivo, following a 5-day supracalvarial injection of LPS or tumor necrosis factor-alpha (TNF-α) with or without azilsartan, the proportion of bone resorption and the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells, which are identified as osteoclasts on mice calvariae were counted. The mRNA expression levels of TRAP, cathepsin K, receptor activator of NF-κB ligand (RANKL), and TNF-α were also evaluated. In vitro, the effect of azilsartan (0, 0.01, 0.1, 1, and 10 μM) on RANKL and TNF-α-triggered osteoclastogenesis were investigated. Also, whether azilsartan restrains LPS-triggered TNF-α mRNA and protein expression in macrophages and RANKL expression in osteoblasts were assessed. Furthermore, western blotting for analysis of mitogen-activated protein kinases (MAPKs) signaling was conducted. RESULTS: Azilsartan-treated calvariae exhibited significantly lower bone resorption and osteoclastogenesis than those treated with LPS alone. In vivo, LPS with azilsartan administration resulted in lower levels of receptor activator of RANKL and TNF-α mRNA expression than LPS administration alone. Nevertheless, azilsartan did not show inhibitory effect on RANKL- and TNF-α-triggered osteoclastogenesis in vitro. Compared to macrophages treated with LPS, TNF-α mRNA and protein levels were lower in macrophages treated by LPS with azilsartan. In contrast, RANKL mRNA and protein expression levels in osteoblasts were the same in cells co-treated with azilsartan and LPS and those exposed to LPS only. Furthermore, azilsartan suppressed LPS-triggered MAPKs signaling pathway in macrophages. After 5-day supracalvarial injection, there is no difference between TNF-α injection group and TNF-α with azilsartan injection group. CONCLUSION: These findings imply that azilsartan prevents LPS-triggered TNF-α production in macrophages, which in turn prevents LPS-Triggered osteoclast formation and bone resorption in vivo.

  13. Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR120. International-journal Peer-reviewed

    Jinghan Ma, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Kayoko Kanou, Akiko Kishikawa, Atsuhiko Ichimura, Itaru Mizoguchi

    Frontiers in immunology　13　929690-929690　2023/01

    DOI： 10.3389/fimmu.2022.929690 　

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    Docosahexaenoic acid (DHA) is an omega-3 fatty acid that has a range of positive impacts on human health, including anti-inflammatory effects and inhibition of osteoclast formation via G-protein-coupled receptor 120 (GPR120). Orthodontic force was reported to induce tumor necrosis factor-α (TNF-α) expression, which activates osteoclast differentiation during orthodontic tooth movement (OTM). The aim of this study was to investigate the influence of DHA on TNF-α-induced osteoclast formation and OTM in vivo. We examined osteoclast formation and bone resorption within the calvaria of both wild-type (WT) and GPR120-deficient (GPR120-KO) mice injected with phosphate-buffered saline (PBS), TNF-α, TNF-α and DHA, or DHA. DHA inhibited TNF-α-induced osteoclast formation and bone resorption in WT mice but had no effect in GPR120-KO mice. OTM experiments were performed in mouse strains with or without regular injection of DHA, and the effects of DHA on osteoclast formation in the alveolar bones during OTM were examined. DHA also suppressed OTM in WT but not GPR120-KO mice. Our data showed that DHA suppresses TNF-α-induced osteoclastogenesis and bone resorption via GPR120. TNF-α has considerable significance in OTM, and therefore, DHA may also inhibit TNF-α-induced osteoclast formation and bone resorption in OTM.

  14. The osteocyte and its osteoclastogenic potential. International-journal Peer-reviewed

    Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Itaru Mizoguchi

    Frontiers in endocrinology　14　1121727-1121727　2023

    DOI： 10.3389/fendo.2023.1121727 　

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    The skeleton is an organ of dual functionality; on the one hand, it provides protection and structural competence. On the other hand, it participates extensively in coordinating homeostasis globally given that it is a mineral and hormonal reservoir. Bone is the only tissue in the body that goes through strategically consistent bouts of bone resorption to ensure its integrity and organismal survival in a temporally and spatially coordinated process, known as bone remodeling. Bone remodeling is directly enacted by three skeletal cell types, osteoclasts, osteoblasts, and osteocytes; these cells represent the acting force in a basic multicellular unit and ensure bone health maintenance. The osteocyte is an excellent mechanosensory cell and has been positioned as the choreographer of bone remodeling. It is, therefore, not surprising that a holistic grasp of the osteocyte entity in the bone is warranted. This review discusses osteocytogenesis and associated molecular and morphological changes and describes the osteocytic lacunocanalicular network (LCN) and its organization. We highlight new knowledge obtained from transcriptomic analyses of osteocytes and discuss the regulatory role of osteocytes in promoting osteoclastogenesis with an emphasis on the case of osteoclastogenesis in anosteocytic bones. We arrive at the conclusion that osteocytes exhibit several redundant means through which osteoclast formation can be initiated. However, whether osteocytes are true "orchestrators of bone remodeling" cannot be verified from the animal models used to study osteocyte biology in vivo. Results from studying osteocyte biology using current animal models should come with the caveat that these models are not osteocyte-specific, and conclusions from these studies should be interpreted cautiously.

  15. Titanium nanotopography induces osteocyte lacunar-canalicular networks to strengthen osseointegration. International-journal Peer-reviewed

    Xindie He, Masahiro Yamada, Jun Watanabe, Watcharaphol Tiskratok, Minoru Ishibashi, Hideki Kitaura, Itaru Mizoguchi, Hiroshi Egusa

    Acta biomaterialia　151　613-627　2022/10/01

    DOI： 10.1016/j.actbio.2022.08.023 　

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    Osteocyte network architecture is closely associated with bone turnover. The cellular mechanosensing system regulates osteocyte dendrite formation by enhancing focal adhesion. Therefore, titanium surface nanotopography might affect osteocyte network architecture and improve the peri-implant bone tissue quality, leading to strengthened osseointegration of bone-anchored implants. We aimed to investigate the effects of titanium nanosurfaces on the development of osteocyte lacunar-canalicular networks and osseointegration of dental implants. Alkaline etching created titanium nanosurfaces with anisotropically patterned dense nanospikes, superhydrophilicity, and hydroxyl groups. MLO-Y4 mouse osteocyte-like cells cultured on titanium nanosurfaces developed neuron-like dendrites with increased focal adhesion assembly and gap junctions. Maturation was promoted in osteocytes cultured on titanium nanosurfaces compared to cells cultured on machined or acid-etched micro-roughened titanium surfaces. Osteocytes cultured in type I three-dimensional collagen gels for seven days on nano-roughened titanium surfaces displayed well-developed interconnectivity with highly developed dendrites and gap junctions compared to the poor interconnectivity observed on the other titanium surfaces. Even if superhydrophilicity and hydroxyl groups were maintained, the loss of anisotropy-patterned nanospikes reduced expression of gap junction in osteocytes cultured on alkaline-etched titanium nanosurfaces. Four weeks after placing the titanium nanosurface implants in the upper jawbone of wild-type rats, osteocytes with numerous dendrites were found directly attached to the implant surface, forming well-developed lacunar-canalicular networks around the nano-roughened titanium implants. The osseointegration strength of the nano-roughened titanium implants was significantly higher than that of the micro-roughened titanium implants. These data indicate that titanium nanosurfaces promote osteocyte lacunar-canalicular network development via nanotopographical cues and strengthen osseointegration. STATEMENT OF SIGNIFICANCE: The clinical stability of bone-anchoring implant devices is influenced by the bone quality. The osteocyte network potentially affects bone quality and is established by the three-dimensional (3D) connection of neuron-like dendrites of well-matured osteocytes within the bone matrix. No biomaterials are known to regulate formation of the osteocyte network. The present study provides the first demonstration that titanium nanosurfaces with nanospikes created by alkali-etching treatment enhance the 3D formation of osteocyte networks by promoting osteocyte dendrite formation and maturation by nanotopographic cues, leading to strengthened osseointegration of titanium implants. Osteocytes attached to the titanium nanosurfaces via numerous cellular projections. The success of osteocyte regulation by nanotechnology paves the way for development of epoch-making technologies to control bone quality.

  16. Analysis of Coating Loss from Coated Stainless Steel Orthodontic Wire Peer-reviewed

    Arata Ito, Hideki Kitaura, Takahiro Noguchi, Fumitoshi Ohori, Itaru Mizoguchi

    APPLIED SCIENCES-BASEL　12　(19)　2022/10

    DOI： 10.3390/app12199497 　

    eISSN： 2076-3417

  17. Effects of anti-mouse RANKL antibody on orthodontic tooth movement in mice International-journal Peer-reviewed

    Masako Yoshimatsu, Hideki Kitaura, Yukiko Morita, Takuya Nakamura, Takashi Ukai

    Journal of Dental Sciences　17　(3)　1087-1095　2022/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.jds.2022.02.007 　

    ISSN： 1991-7902

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    BACKGROUND/PURPOSE: Orthodontic tooth movement is achieved by alveolar bone remodeling, and therefore the balance of bone resorption and formation is important. Receptor activator of nuclear factor-κB ligand (RANKL) plays a crucial role in bone resorption. We previously reported that tumor necrosis factor-α (TNF-α) is also important in bone resorption during tooth movement. In this study, we focused on bone and root resorption during orthodontic tooth movement in mice using anti-mouse RANKL antibody (anti-mRANKL ab). MATERIALS AND METHODS: Anti-mRANKL ab was administered intraperitoneally to mice that subsequently underwent orthodontic tooth movement. After 10 days, tissues around the moved teeth were histologically evaluated. To confirm the effects of anti-mRANKL ab on TNF-α induced bone resorption, TNF-α was administered with and without anti-mRANKL ab into the supracalvaria and the sutures of the calvaria were histologically evaluated. RESULTS: Orthodontic tooth movement was suppressed in mice treated with anti-mRANKL ab. Root resorption was observed after orthodontic tooth movement, but not in mice treated with anti-mRANKL ab. In the calvarial experiment, the number of TRAP-positive cells in the calvarial sutures was lower in mice administered TNF-α with anti-mRANKL ab than in mice administered TNF-α alone. CONCLUSION: Our findings suggest that anti-mRANKL ab suppressed orthodontic tooth movement. This needs to be considered when orthodontic tooth movement is required in patients using anti-RANKL antibody.

  18. Enhancement of orthodontic tooth movement and root resorption in ovariectomized mice. International-journal Peer-reviewed

    Yasuhiko Nara, Hideki Kitaura, Aseel Marahleh, Fumitoshi Ohori, Takahiro Noguchi, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi

    Journal of dental sciences　17　(2)　984-990　2022/04

    DOI： 10.1016/j.jds.2021.11.009 　

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    Background/purpose: As the number of patients with osteoporosis requiring orthodontic treatment is increasing with the aging of society, it is necessary to evaluate the relations between bone metabolism in old age and orthodontic tooth movement (OTM). However, the effects of changes in bone metabolism due to osteoporosis on OTM and root resorption are still unclear. Therefore, we investigated the effects of OTM and root resorption in a mouse ovariectomy (OVX)-induced osteoporosis model. Materials and methods: Eight-week-old female wild-type mice underwent OVX or sham surgery (Sham) as controls. One month after treatment, a nickel titanium coil spring was used to apply a mesial force to the maxillary left first molars of OVX or Sham mice for 12 days. The distance between the maxillary first molar and the second molar changed due to OTM and osteoclast formation was evaluated. The odontoclast formation and root resorption along the root surface of the distobuccal root of the first molar was also evaluated by histological analysis and scanning electron microscopy. Results: Distance of tooth movement and osteoclast formation were significantly increased in OVX mice compared to Sham controls. Furthermore, root resorption in the mesial surface of the distal molars induced by orthodontic force was significantly increased in OVX mice. Conclusion: The amount of OTM was significantly increased, and the accompanying root resorption was also increased in OVX mice. Therefore, attention should be paid to the risk of root resorption associated with orthodontic treatment in patients with osteoporosis.

  19. Micro-Osteoperforations Induce TNF-α Expression and Accelerate Orthodontic Tooth Movement via TNF-α-Responsive Stromal Cells. International-journal Peer-reviewed

    Ria Kinjo, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi

    International journal of molecular sciences　23　(6)　2022/03/09

    DOI： 10.3390/ijms23062968 　

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    Micro-osteoperforations (MOPs) have been reported to accelerate orthodontic tooth movement (OTM), and tumor necrosis factor (TNF)-α has been reported to play a crucial role in OTM. In this report, the influence of MOPs during OTM was analyzed. We evaluated the expression of TNF-α with and without MOPs by RT-PCR analysis. A Ni-Ti closed coil spring was fixed between the maxillary left first molar and the incisors as an OTM mouse model to move the first molar in the mesial direction. MOPs were prepared on the lingual side and mesial side of the upper first molars. Furthermore, to investigate the target cell of TNF-α for osteoclast formation during OTM with MOPs in vivo, we created four types of chimeric mice in which bone marrow of wild-type (WT) or TNF receptor 1- and 2-deficient mice (KO) was transplanted into lethally irradiated WT or KO mice. The results showed that MOPs increased TNF-α expression, the distance of tooth movement and osteoclast formation significantly. Furthermore, mice with TNF-α-responsive stromal cells showed a significant increase in tooth movement and number of osteoclasts by MOPs. We conclude that MOPs increase TNF-α expression, and tooth movement is dependent on TNF-α-responsive stromal cells.

  20. C‑X‑C receptor 7 agonist acts as a C‑X‑C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption. International-journal Peer-reviewed

    Alexander Patera Nugraha, Hideki Kitaura, Fumitoshi Ohori, Adya Pramusita, Saika Ogawa, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Ria Kinjo, Itaru Mizoguchi

    Molecular medicine reports　25　(3)　2022/03

    DOI： 10.3892/mmr.2022.12594 　

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    The C‑X‑C receptor (CXCR) 7 agonist, VUF11207, is a chemical compound that binds specifically to CXCR7, and negatively regulates C‑X‑C motif chemokine ligand 12 (CXCL12) and CXCR4‑induced cellular events. Lipopolysaccharide (LPS) can induce inflammatory cytokines and pathological bone loss. LPS also induces expression of CXCL12, enhancing sensitivity to receptor activator of NF‑κB ligand (RANKL) and tumor necrosis factor‑α (TNF‑α) in vivo. RANKL and TNF‑α induce the differentiation of osteoclasts into osteoclast precursors and bone resorption. The current study was performed to examine the effects of a CXCR7 agonist on osteoclastogenesis and bone resorption induced by LPS in vivo. In addition, the mechanisms underlying these in vivo effects were investigated by in vitro experiments. Eight‑week‑old male C57BL/6J mice were subcutaneously injected over the calvariae with LPS alone or LPS and CXCR7 agonist. After sacrifice, the number of osteoclasts and the bone resorption area were measured. In vitro experiments were performed to investigate the effects of CXCL12 and CXCR7 agonist on osteoclastogenesis induced by RANKL and TNF‑α. Mice injected with LPS and CXCR7 agonist showed significantly reduced osteoclastogenesis and bone resorption compared with mice injected with LPS alone. Moreover, the CXCR7 agonist inhibited CXCL12 enhancement of RANKL‑ and TNF‑α‑induced osteoclastogenesis in vitro. Thus, CXCR7 agonist inhibited LPS‑induced osteoclast‑associated cytokines, such as RANKL and TNF‑α, as well as RANKL‑ and TNF‑α‑induced osteoclastogenesis in vitro by modulating CXCL12‑mediated enhancement of osteoclastogenesis. In conclusion, CXCR7 agonist reduced CXCL12‑mediated osteoclastogenesis and bone resorption.

  21. Role of the Interaction of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors 1 and 2 in Bone-Related Cells. International-journal Peer-reviewed

    Hideki Kitaura, Aseel Marahleh, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi

    International journal of molecular sciences　23　(3)　2022/01/27

    DOI： 10.3390/ijms23031481 　

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    Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine expressed by macrophages, monocytes, and T cells, and its expression is triggered by the immune system in response to pathogens and their products, such as endotoxins. TNF-α plays an important role in host defense by inducing inflammatory reactions such as phagocytes and cytocidal systems activation. TNF-α also plays an important role in bone metabolism and is associated with inflammatory bone diseases. TNF-α binds to two cell surface receptors, the 55kDa TNF receptor-1 (TNFR1) and the 75kDa TNF receptor-2 (TNFR2). Bone is in a constant state of turnover; it is continuously degraded and built via the process of bone remodeling, which results from the regulated balance between bone-resorbing osteoclasts, bone-forming osteoblasts, and the mechanosensory cell type osteocytes. Precise interactions between these cells maintain skeletal homeostasis. Studies have shown that TNF-α affects bone-related cells via TNFRs. Signaling through either receptor results in different outcomes in different cell types as well as in the same cell type. This review summarizes and discusses current research on the TNF-α and TNFR interaction and its role in bone-related cells.

  22. Salt-Sensitive Hypertension Induces Osteoclastogenesis and Bone Resorption via Upregulation of Angiotensin II Type 1 Receptor Expression in Osteoblasts. International-journal Peer-reviewed

    Adya Pramusita, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Yukinori Tanaka, Itaru Mizoguchi

    Frontiers in cell and developmental biology　10　816764-816764　2022

    DOI： 10.3389/fcell.2022.816764 　

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    Hypertension is a chronic-low grade inflammatory disease, which is known to be associated with increased bone loss. Excessive activity of the local renin-angiotensin system (RAS) in bone leads to increased bone resorption. As inflammatory cytokines may activate RAS components, we hypothesized that the elevated proinflammatory cytokine levels in hypertension activate bone RAS and thus lead to increased bone resorption. To investigate whether salt-sensitive hypertension (SSHTN) induces osteoclastogenesis and bone resorption, we generated a model of SSHTN in C57BL/6J mice by post-N ω-nitro-l-arginine methyl ester hydrochloride (l-NAME) high-salt challenge. SSHTN led to the reduction of distal femur trabecular number and bone volume fraction, while trabecular separation of femoral bone showed a significant increase, with no change in cortical thickness. Histomorphometric examination showed a significant reduction in trabecular bone volume fraction with an increased number of multinucleated tartrate-resistant acid phosphatase (TRAP)-positive cells and increased osteoclast surface fraction in the trabecular distal femur of hypertensive mice. Furthermore, analysis of gene expression in bone tissue revealed that TRAP and RANKL/OPG mRNA were highly expressed in hypertensive mice. TNF-α and angiotensin II type 1 receptor (AGTR1) mRNA and protein expression were also upregulated in SSHTN mice. These observations suggested that TNF-α may have an effect on AGTR1 expression leading to osteoclast activation. However, TNF-α stimulation did not promote AGTR1 mRNA expression in osteoclast precursors in culture, while TNF-α increased AGTR1 mRNA expression in osteoblast culture by activation of downstream p38. Angiotensin II was also shown to increase TNF-α-induced RANKL/OPG mRNA expression in primary osteoblast culture and osteoclastogenesis in a TNF-α-primed osteoblast and osteoclast precursor co-culture system. In addition, local injection of lipopolysaccharide into the supracalvariae of SSHTN mice markedly promoted osteoclast and bone resorption. In conclusion, mice with SSHTN show increased osteoclastogenesis and bone resorption due mainly to increased TNF-α and partly to the upregulation of AGTR1 in osteoblasts.

  23. Craniofacial Characteristics and Orthodontic Treatment of Diamond Blackfan Syndrome: Two Case Reports. International-journal Peer-reviewed

    Satoshi Sasaki, Hideki Kitaura, Maki Goto, Michiko Yoshida, Itaru Mizoguchi

    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association　60　(1)　10556656211053774-10556656211053774　2021/11/17

    DOI： 10.1177/10556656211053774 　

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    Diamond Blackfan anemia (DBA) is a chronic congenital form of erythrocytic hypoplasia in which erythroid precursor cell levels are low. DBA reflects ribosomal dysfunction and is accompanied by hematopoietic cell apoptosis, anemia, and various somatic symptoms. We report the characteristic symptoms of the craniofacial region and the orthodontic treatments of two DBA cases. Case 1 was a 12-year-old female. The typical physical and facial characteristics of DBA were lacking. On initial examination, she exhibited a skeletal Class II jaw and end to end molar relationships and a large overjet. An edgewise appliance was placed after extraction of the first maxillary premolars. After 3 years and 11 months, an appropriate overjet and overbite, rigid intercuspation, and an acceptable profile were evident without any clinical adverse effects. Case 2 was a 13-year-old female. She exhibited a skeletal Class I jaw relationship, a spaced dental arch, the maxillofacial dysplasia characteristic of Binder syndrome, hypoplasia of the right mandibular condyle, and labial protrusions of the maxillary and mandibular incisors. We placed an edgewise appliance and after 1 year and 7 months, the occlusion was optimal in the absence of any adverse effects. Our two DBA cases exhibited a broad spectrum of physical and dentofacial symptoms. Patients with DBA are often prescribed combined steroid/bisphosphonate therapies. Both agents are likely to affect alveolar bone remodeling after tooth extraction and orthodontic tooth movement. Careful consideration of medication with reference to various dentofacial characteristics is necessary.

  24. Titanium Nitride Plating Reduces Nickel Ion Release from Orthodontic Wire Invited Peer-reviewed

    Arata Ito, Hideki Kitaura, Haruki Sugisawa, Takahiro Noguchi, Fumitoshi Ohori, Itaru Mizoguchi

    APPLIED SCIENCES-BASEL　11　(20)　2021/10

    DOI： 10.3390/app11209745 　

    eISSN： 2076-3417

  25. Tumor necrosis factor-α enhances the expression of vascular endothelial growth factor in a mouse orthodontic tooth movement model International-journal Peer-reviewed

    Takahiro Noguchi, Hideki Kitaura, Aseel Marahleh, Fumitoshi Ohori, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi

    Journal of Dental Sciences　17　(1)　415-420　2021/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.jds.2021.08.011 　

    ISSN： 1991-7902

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    BACKGROUND/PURPOSE: Tooth movement that is achieved using orthodontic mechanical principles relies on bone resorption which takes place on the compression side via osteoclasts. Tumor necrosis factor-α (TNF-α) has been known to affect osteoclast formation in orthodontic tooth movement (OTM). Vascular endothelial growth factor (VEGF), which is one of the mediators of angiogenesis, also plays an important role in OTM by inducing vascular permeability and chemotaxis of osteoclast precursors. Therefore, the purpose of this research was to evaluate the effect of TNF-α on VEGF expression during OTM. MATERIALS AND METHODS: In order to demonstrate the effect of TNF-α on VEGF expression during OTM, a nickel titanium closed coil spring was fixed to the upper left first molar and the alveolar bone beneath the upper incisors of both wild type (WT) and TNF receptors (TNFRs) deficient mice resulting in a mesial movement of the molar for 12 days. The maxilla was removed for histological analysis and real-time RCR analysis of VEGF expression. RESULTS: Immunohistochemical analysis revealed that there were fewer VEGF-positive cells in the periodontal membrane on the mesial side of the distobuccal root in TNFRs-deficient mice than that in WT mice during the OTM for 12 days. Furthermore, expression of VEGF mRNA is lower level in TNFRs-deficient mice than that in WT mice. CONCLUSION: Our results indicate that TNF-α plays an important role in VEGF expression during tooth movement.

  26. Effects of Incretin-Related Diabetes Drugs on Bone Formation and Bone Resorption International-journal Peer-reviewed

    Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi

    International Journal of Molecular Sciences　22　(12)　6578-6578　2021/06/19

    Publisher: MDPI AG

    DOI： 10.3390/ijms22126578 　

    eISSN： 1422-0067

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    Patients with type 2 diabetes have an increased risk of fracture compared to the general population. Glucose absorption is accelerated by incretin hormones, which induce insulin secretion from the pancreas. The level of the incretin hormone, glucagon-like peptide-1 (GLP-1), shows an immediate postprandial increase, and the circulating level of intact GLP-1 is reduced rapidly by dipeptidyl peptidase-4 (DPP-4)-mediated inactivation. Therefore, GLP-1 receptor agonists and DPP-4 inhibitors are effective in the treatment of type 2 diabetes. However, these incretin-related diabetic agents have been reported to affect bone metabolism, including bone formation and resorption. These agents enhance the expression of bone markers, and have been applied to improve bone quality and bone density. In addition, they have been reported to suppress chronic inflammation and reduce the levels of inflammatory cytokine expression. Previously, we reported that these incretin-related agents inhibited both the expression of inflammatory cytokines and inflammation-induced bone resorption. This review presents an overview of current knowledge regarding the effects of incretin-related diabetes drugs on osteoblast differentiation and bone formation as well as osteoclast differentiation and bone resorption. The mechanisms by which incretin-related diabetes drugs regulate bone formation and bone resorption are also discussed.

  27. The miR-155-5p inhibits osteoclast differentiation through targeting CXCR2 in orthodontic root resorption. International-journal Peer-reviewed

    Hongtao Jiang, Hideki Kitaura, Lin Liu, Itaru Mizoguchi, Shiying Liu

    Journal of periodontal research　2021/03/24

    DOI： 10.1111/jre.12875 　

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    BACKGROUND AND OBJECTIVE: Root resorption is an unavoidable side effect of orthodontic tooth movement. The mechanism of root resorption is similar to bone resorption; the odontoclasts share similar characteristics with osteoclasts (OCs). MicroRNAs (miRNAs) such as miR-155-5p play an important role in OC differentiation, but the underlying molecular mechanism of miR-155-5p in this process is not fully understood. We found that the miR-155-5p seed sequences were complementary to a sequence conserved in the 3-untranslated region of CXCR2 mRNA. In this study, we explored the molecular mechanism underlying the effect of miR-155-5p on OC differentiation by targeting CXCR2. MATERIALS AND METHODS: In this study, we divided the orthodontic patients into mild, moderate, and severe groups according to the severity of root resorption. The gingival crevicular fluid (GCF) of patients in different groups was collected, and the expression levels of dentin phosphoprotein (DPP) were detected by ELISA, and the expression levels of CXCR2 and miR-155-5p in GCF were detected by real-time quantitative PCR (qRT-PCR). The relationship between miR-155-5p and CXCR2 was verified by double luciferase. We analyzed changes of CXCR2 and miR-155-5p expression after transfection of miR-155-5p mimic and inhibitor into RAW264.7 cells induced by receptor activator of nuclear factor-κB ligand (RANKL) through qRT-PCR and western blotting. The effect of miR-155-5p on OC differentiation was evaluated by tartrate-resistant acid phosphatase (TRAP) staining. QRT-PCR and western blotting were used to analyze expression of the osteoclastic bone resorption-related enzymes carbonic anhydrase 2 (CA II), matrix metalloproteinase-9 (MMP-9), and cathepsin K. To further confirm the direct targeting effect of CXCR2 by miR-155-5p, we blocked CXCR2 using si-CXCR2 in RANKL-induced RAW264.7 cells. RESULTS: Dentin phosphoprotein levels were consistent with the trend of miR-155-5p changes, and the trend of CXCR2 expression was opposite to miR-155-5p changes. miR-155-5p can be directly targeted to act on CXCR2. The expression of miR-155-5p was significantly downregulated in differentiated OCs. MiR-155-5p inhibited OC differentiation, and downregulated CA II, MMP-9, and cathepsin K expression at the protein and mRNA levels. CONCLUSIONS: In summary, the results of this study suggested that miR-155-5p inhibited OC differentiation by targeting CXCR2, thus reducing root resorption in orthodontics. MiR-155-5p can be used as an effective target for avoiding or reducing the degree of root resorption in orthodontic treatment.

  28. Effect of TNF-α on osteocyte RANKL expression during orthodontic tooth movement International-journal Peer-reviewed

    Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi

    Journal of Dental Sciences　16　(4)　1191-1197　2021/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.jds.2021.03.006 　

    ISSN： 1991-7902

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    BACKGROUND/PURPOSE: Orthodontic tooth movement (OTM) is facilitated by two events; bone resorption on the compression side and bone formation on the tension side simultaneously termed bone remodeling. Osteocytes play a critical role in bone remodeling during OTM, as they have been described as the critical source of nuclear factor-κB ligand (RANKL) necessary for bone remodeling during OTM. Tumor necrosis factor (TNF)-α is a cytokine that acts by amplifying RANKL expression in osteocytes. In this study, we evaluated the effects of TNF-α on RANKL expression in osteocyte during OTM. MATERIALS AND METHODS: We assessed whether TNF-α influenced RANKL expression in osteocyte during orthodontic tooth movement by using wild-type (WT) and TNF receptor I and II deficient (TNFRsKO) mice. A Nickel-titanium closed coil spring was attached to the maxillary alveolar bone near the incisors and the upper left first molar, and the first molars were moved mesially in WT and TNFRsKO mice. After OTM, the number of RANKL-positive osteocytes in the alveolar bone was evaluated by immunohistochemistry. RESULTS: The number of RANKL-positive osteocyte in the alveolar bone significantly increased in WT mice than in TNFRsKO mice after OTM. CONCLUSION: The results indicate that TNF-α induces the expression of RANKL in osteocyte during OTM.

  29. Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation. International-journal Peer-reviewed

    Tatsuya Hasegawa, V Venkata Suresh, Yoshio Yahata, Masato Nakano, Shigeto Suzuki, Shigeki Suzuki, Satoru Yamada, Hideki Kitaura, Itaru Mizoguchi, Yuichiro Noiri, Keisuke Handa, Masahiro Saito

    Scientific reports　11　(1)　2613-2613　2021/01/28

    DOI： 10.1038/s41598-021-82167-7 　

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    Apical periodontitis (AP) is an acute or chronic inflammatory disease caused by complex interactions between infected root canal and host immune system. It results in the induction of inflammatory mediators such as chemokines and cytokines leading to periapical tissue destruction. To understand the molecular pathogenesis of AP, we have investigated inflammatory-related genes that regulate AP development. We found here that macrophage-derived CXCL9, which acts through CXCR3, is recruited by progressed AP. The inhibition of CXCL9 by a CXCR3 antagonist reduced the lesion size in a mouse AP model with decreasing IL-1β, IL-6 and TNFα expression. The treatment of peritoneal macrophages with CXCL9 and LPS induced the transmigration and upregulation of osteoclastogenic cytokines such as IL-1β, IL-6 and matrix metalloprotease 2, a marker of activated macrophages. This suggests that the CXCL9-CXCR3 axis plays a crucial role in the development of AP, mediated by the migration and activation of macrophages for periapical tissue destruction. Our data thus show that CXCL9 regulates the functions of macrophages which contribute to AP pathogenesis, and that blocking CXCL9 suppresses AP progression. Knowledge of the principal factors involved in the progression of AP, and the identification of related inflammatory markers, may help to establish new therapeutic strategies.

  30. Local administration of high-dose diabetes medicine exendin-4 inhibits orthodontic tooth movement in mice. International-journal Peer-reviewed

    Wei-Ren Shen, Hideki Kitaura, Jiawei Qi, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Pramusita Adya, Itaru Mizoguchi

    The Angle orthodontist　91　(1)　111-118　2021/01/01

    DOI： 10.2319/021320-103.1 　

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    OBJECTIVES: To investigate the effects of exendin-4 on orthodontic tooth movement distance, root resorption, and expression levels of osteoclast-related cytokines in a mouse model. MATERIALS AND METHODS: A 10-g NiTi coil spring was placed between the anterior alveolar bone and upper left first molar of 8-week-old male C57BL/6 mice. Twenty microliters of exendin-4 solution (containing 0.2 μg, 4 μg, or 20 μg exendin-4) or phosphate-buffered saline (PBS) were injected on the buccal side of the upper left first molar at 2-day intervals (4 mice per group). Mice were sacrificed on day 12; silicone impressions were taken to record tooth movement distance. The left maxillae of the PBS and 20 μg exendin-4 groups were also excised for histological analysis and quantitative reverse transcription polymerase chain reaction analysis. RESULTS: Orthodontic tooth movement distance was smaller in the 20 μg exendin-4 group than in the PBS group (P < .01). Compared with the PBS group, the 20 μg exendin-4 group showed lower osteoclast number (P < .05), odontoclast number (P < .05), and root resorption surface percentage (P < .05). Relative to maxillae with PBS injections, maxillae with 20 μg exendin-4 injections had lower receptor activator of nuclear factor kappa-B ligand (RANKL) mRNA expression (P < .05), TNF-α mRNA expression (P < .05), and RANKL/osteoprotegerin (OPG) ratio (P < .01). There were no differences in the expression of OPG mRNA. CONCLUSIONS: Exendin-4 inhibits orthodontic tooth movement. Therefore, additional attention is needed for orthodontic patients who receive exendin-4 for diabetes treatment. GLP-1 receptor may be a treatment target for patients with severe root resorption.

  31. Erratum for Compressive Force-Produced CCN2 Induces Osteocyte Apoptosis through ERK1/2 Pathway. International-journal

    Kenji Hoshi, Harumi Kawaki, Ichiro Takahashi, Nobuo Takeshita, Masahiro Seiryu, Sakhr A Murshid, Taisuke Masuda, Takahisa Anada, Ryushi Kato, Hideki Kitaura, Osamu Suzuki, Teruko Takano-Yamamoto

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research　35　(11)　2303-2304　2020/11

    DOI： 10.1002/jbmr.4169 　

    ISSN： 0884-0431

    eISSN： 1523-4681

  32. TNF-α stimulates the expression of RANK during orthodontic tooth movement International-journal Peer-reviewed

    Takahiro Noguchi, Hideki Kitaura, Saika Ogawa, Jiawei Qi, Wei Ren Shen, Fumitoshi Ohori, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Itaru Mizoguchi

    Archives of Oral Biology　117　104796-104796　2020/09

    DOI： 10.1016/j.archoralbio.2020.104796 　

    ISSN： 0003-9969

    eISSN： 1879-1506

  33. Anti-C-FMS antibody prevents osteoclast formation and bone resorption in co-culture of osteoblasts and osteoclast precursors in vitro and in ovariectomized mice International-journal Peer-reviewed

    Yasuhiko Nara, Hideki Kitaura, Saika Ogawa, Wei Ren Shen, Jiawei Qi, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi

    International Journal of Molecular Sciences　21　(17)　1-16　2020/09/01

    DOI： 10.3390/ijms21176120 　

    ISSN： 1661-6596

    eISSN： 1422-0067

  34. Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption. International-journal Peer-reviewed

    Hideki Kitaura, Aseel Marahleh, Fumitoshi Ohori, Takahiro Noguchi, Wei-Ren Shen, Jiawei Qi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi

    International journal of molecular sciences　21　(14)　2020/07/21

    DOI： 10.3390/ijms21145169 　

    ISSN： 1661-6596

    eISSN： 1422-0067

  35. Obtaining Primary Osteocytes through Murine Calvarial Fractionation of GFP-Expressing Osteocytes. International-journal Peer-reviewed

    Aseel Marahleh, Hideki Kitaura, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi

    Journal of visualized experiments : JoVE　2020　(160)　1-6　2020/06/02

    DOI： 10.3791/61513 　

    ISSN： 1940-087X

  36. IL-33 inhibits TNF-α-induced osteoclastogenesis and bone resorption International-journal Peer-reviewed

    Fumitoshi Ohori, Hideki Kitaura, Saika Ogawa, Wei Ren Shen, Jiawei Qi, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Itaru Mizoguchi

    International Journal of Molecular Sciences　21　(3)　2020/02/01

    DOI： 10.3390/ijms21031130 　

    ISSN： 1661-6596

    eISSN： 1422-0067

  37. Effect of a DPP-4 Inhibitor on Orthodontic Tooth Movement and Associated Root Resorption International-journal Peer-reviewed

    Jiawei Qi, Hideki Kitaura, Wei Ren Shen, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Pramusita Adya, Itaru Mizoguchi

    BioMed Research International　2020　7189084-7189084　2020

    Publisher: Hindawi Limited

    DOI： 10.1155/2020/7189084 　

    ISSN： 2314-6133

    eISSN： 2314-6141

  38. 東北大学病院矯正歯科における7年間の外科的矯正症例動向調査

    佐々木 聡史, 北浦 英樹, 大堀 文俊, 野口 隆弘, 小川 紗衣香, 真山 敦, 溝口 到

    東北矯正歯科学会雑誌　27　(1)　82-82　2019/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  39. TNF-α is responsible for the contribution of stromal cells to osteoclast and odontoclast formation during orthodontic tooth movement International-journal Peer-reviewed

    Saika Ogawa, Hideki Kitaura, Akiko Kishikawa, Jiawei Qi, Wei Ren Shen, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Yumiko Ochi, Itaru Mizoguchi

    PLoS ONE　14　(10)　e0223989　2019/10/01

    DOI： 10.1371/journal.pone.0223989 　

    eISSN： 1932-6203

  40. Establishment of an orthodontic retention mouse model and the effect of anti-c-Fms antibody on orthodontic relapse International-journal Peer-reviewed

    Jiawei Qi, Hideki Kitaura, Wei Ren Shen, Akiko Kishikawa, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Itaru Mizoguchi

    PLoS ONE　14　(6)　e0214260　2019/06

    DOI： 10.1371/journal.pone.0214260 　

    eISSN： 1932-6203

  41. Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro International-journal Peer-reviewed

    Aseel Marahleh, Hideki Kitaura, Masahiko Ishida, Kazuhiro Shima, Akiko Kishikawa, Saika Ogawa, Wei Ren Shen, Jiawei Qi, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi

    Journal of visualized experiments : JoVE　(145)　2019/03/18

    DOI： 10.3791/59089 　

    eISSN： 1940-087X

  42. DPP-4 inhibitor impedes lipopolysaccharide-induced osteoclast formation and bone resorption in vivo International-journal

    Masahiko Ishida, Wei Ren Shen, Keisuke Kimura, Akiko Kishikawa, Kazuhiro Shima, Saika Ogawa, Jiawei Qi, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Hideki Kitaura

    Biomedicine and Pharmacotherapy　109　242-253　2019/01

    DOI： 10.1016/j.biopha.2018.10.052 　

    ISSN： 0753-3322

    eISSN： 1950-6007

  43. TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation. International-journal Peer-reviewed

    Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Akiko Kishikawa, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi

    Frontiers in immunology　10　2925-2925　2019

    DOI： 10.3389/fimmu.2019.02925 　

    eISSN： 1664-3224

  44. Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement. International-journal Peer-reviewed

    Fumitoshi Ohori, Hideki Kitaura, Aseel Marahleh, Akiko Kishikawa, Saika Ogawa, Jiawei Qi, Wei-Ren Shen, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi

    Journal of immunology research　2019　9716758-9716758　2019

    DOI： 10.1155/2019/9716758 　

    ISSN： 2314-8861

    eISSN： 2314-7156

  45. Docosahexaenoic acid inhibits inflammation-induced osteoclast formation and bone resorption in vivo through GPR120 by inhibiting TNF-α production in macrophages and directly inhibiting osteoclast formation International-journal Peer-reviewed

    Akiko Kishikawa, Hideki Kitaura, Keisuke Kimura, Saika Ogawa, Jiawei Qi, Wei Ren Shen, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Atsuhiko Ichimura, Itaru Mizoguchi

    Frontiers in Endocrinology　10　(MAR)　157-157　2019

    DOI： 10.3389/fendo.2019.00157 　

    eISSN： 1664-2392

  46. 東北大学病院矯正歯科における包括歯科治療へのアプローチ

    関 大輔, 北浦 英樹, 山本 照子

    東北矯正歯科学会雑誌　26　(1)　121-125　2018/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  47. 歯科矯正用Ni-Tiワイヤーの耐食性の解析 Peer-reviewed

    木村 桂介, 井田 裕人, 石田 匡彦, 島 和弘, 岸川 明子, 小川 紗衣香, 北浦 英樹

    東北矯正歯科学会雑誌　26　(1)　140-141　2018/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  48. 過去9年間の東北大学病院矯正歯科における歯科矯正用アンカースクリューの動向調査 Peer-reviewed

    真山 敦, 清流 正弘, 出口 徹, 金原 正敬, 岩崎 将也, 解良 洋平, 宮下 俊郎, 関 大輔, 竹下 信郎, 福永 智広, 北浦 英樹, 山本 照子

    東北矯正歯科学会雑誌　26　(1)　3-8　2018/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  49. C-X-C Motif Chemokine 12 Enhances Lipopolysaccharide-Induced Osteoclastogenesis and Bone Resorption In Vivo International-journal Peer-reviewed

    Kazuhiro Shima, Keisuke Kimura, Masahiko Ishida, Akiko Kishikawa, Saika Ogawa, Jiawei Qi, Wei Ren Shen, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Hideki Kitaura

    Calcified Tissue International　103　(4)　431-442　2018/10/01

    DOI： 10.1007/s00223-018-0435-z 　

    ISSN： 0171-967X

    eISSN： 1432-0827

  50. Role of Muramyl dipeptide in Lipopolysaccharide-mediated biological activity and osteoclast activity International-journal Invited Peer-reviewed

    Hideki Kitaura, Masahiko Ishida, Keisuke Kimura, Haruki Sugisawa, Akiko Kishikawa, Kazuhiro Shima, Saika Ogawa, Jiawei Qi, Wei Ren Shen

    Analytical Cellular Pathology　2018　8047610-8047610　2018

    DOI： 10.1155/2018/8047610 　

    ISSN： 2210-7177

    eISSN： 2210-7185

  51. The glucagon-like peptide-1 receptor agonist exendin-4 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption via inhibition of TNF-α expression in macrophages International-journal Peer-reviewed

    Wei Ren Shen, Keisuke Kimura, Masahiko Ishida, Haruki Sugisawa, Akiko Kishikawa, Kazuhiro Shima, Saika Ogawa, Jiawei Qi, Hideki Kitaura

    Journal of Immunology Research　2018　5783639-5783639　2018

    DOI： 10.1155/2018/5783639 　

    ISSN： 2314-8861

    eISSN： 2314-7156

  52. Corrosion resistance and mechanical properties of titanium nitride plating on orthodontic wires Peer-reviewed

    Haruki Sugisawa, Hideki Kitaura, Kyosuke Ueda, Keisuke Kimura, Masahiko Ishida, Yumiko Ochi, Akiko Kishikawa, Saika Ogawa, Teruko Takano-Yamamoto

    Dental Materials Journal　37　(2)　286-292　2018

    DOI： 10.4012/dmj.2016-348 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  53. 歯科矯正用Ni-Tiワイヤーに対する表面コーティングによる耐食性の解析 Peer-reviewed

    木村 桂介, 杉澤 晴紀, 井田 裕人, 石田 匡彦, 島 和弘, 岸川 明子, 小川 紗衣香, 北浦 英樹

    東北矯正歯科学会雑誌　25　(1)　9-15　2017/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  54. 歯科矯正用アンカースクリューを用いて水平的な咬合平面の傾斜を改善した正中離開症例 Peer-reviewed

    吉澤 光弘, 北浦 英樹, 福永 智広, 山本 照子

    東北大学歯学雑誌　35/36　(2/1)　146-153　2017/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  55. 歯科矯正用アンカースクリューを利用し咬合平面傾斜の改善を行い顎口腔機能の改善が認められた症例 Peer-reviewed

    小針寛子, 北浦英樹, 清流正弘, 山本照子

    東北矯正歯科学会雑誌　24　(1)　70-71　2016/12

    Publisher:

    ISSN： 1340-2668

  56. 東北大学病院矯正歯科に来院した患者の不正咬合と歯肉炎との関係

    福永 智広, 川津 正慶, 後藤 まき, 北浦 英樹, 山本 照子

    東北矯正歯科学会雑誌　24　(1)　51-54　2016/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  57. IL-37 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption in vivo International-journal Peer-reviewed

    Jafari Saeed, Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Haruki Sugisawa, Yumiko Ochi, Akiko Kishikawa, Teruko Takano-Yamamoto

    Immunology Letters　175　8-15　2016/07/01

    DOI： 10.1016/j.imlet.2016.04.004 　

    ISSN： 0165-2478

    eISSN： 1879-0542

  58. 東北大学病院矯正歯科を受診した初診患者の歯肉炎の程度に関する実態調査 Peer-reviewed

    川津 正慶, 福永 智広, 後藤 まき, 木村 晴地, 坂本 麻由里, 宍戸 香, 北浦 英樹, 山本 照子

    東北大学歯学雑誌　34/35　(2/1)　27-31　2016/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  59. Genioplastyを併用した外科的矯正治療による顎顔面形態の変化に伴う顎口腔機能の改善をみた骨格性下顎前突症例 Peer-reviewed

    佐々木 紀代, 清流 正弘, 福永 智広, 出口 徹, 北浦 英樹, 竹下 信郎, 山本 照子

    東北大学歯学雑誌　34/35　(2/1)　32-43　2016/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  60. 外科的矯正治療による顎口腔機能の改善 Invited

    竹下 信郎, 北浦 英樹, 山本 照子

    東北矯正歯科学会雑誌　23　(1)　57-60　2015/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  61. Survey of orthodontic patients in the Tohoku University hospital in the past decade Peer-reviewed

    山本照子, 後藤まき, 北浦英樹, 福永智広, 竹下信郎, 清流正弘, 長谷川正和, 青沼智, 金原正敬, 解良洋平, 川津正慶, 加藤龍史, 木村桂介, 山田雅一, 井田裕人, 佐々木紀代, 宮下俊郎, 吉田倫子, 石田匡彦, 関大輔, 高野郁子, 土江雄治朗, 則松佑佳, 坂東加

    東北大学歯学雑誌　34　(1)　32-37　2015/06

    Publisher:

    ISSN： 0287-3915

  62. Effect of interleukin-4 on orthodontic tooth movement and associated root resorption International-journal Peer-reviewed

    Zaki Hakami, Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Haruki Sugisawa, Hiroto Ida, Saeed Jafari, Teruko Takano-Yamamoto

    European Journal of Orthodontics　37　(1)　87-94　2015/02/01

    DOI： 10.1093/ejo/cju016 　

    ISSN： 0141-5387

    eISSN： 1460-2210

  63. Muramyl dipeptide enhances lipopolysaccharide-induced osteoclast formation and bone resorption through increased RANKL expression in stromal cells International-journal Peer-reviewed

    Masahiko Ishida, Hideki Kitaura, Keisuke Kimura, Haruki Sugisawa, Tomo Aonuma, Haruhiko Takada, Teruko Takano-Yamamoto

    Journal of Immunology Research　2015　132765-132765　2015

    DOI： 10.1155/2015/132765 　

    ISSN： 2314-8861

    eISSN： 2314-7156

  64. IL-12 inhibits lipopolysaccharide stimulated osteoclastogenesis in mice International-journal Peer-reviewed

    Masako Yoshimatsu, Hideki Kitaura, Yuji Fujimura, Haruka Kohara, Yukiko Morita, Noriaki Yoshida

    Journal of Immunology Research　2015　214878-214878　2015

    DOI： 10.1155/2015/214878 　

    ISSN： 2314-8861

    eISSN： 2314-7156

  65. Intra-articular administration of an antibody against CSF-1 receptor reduces pain-related behaviors and inflammation in CFA-induced knee arthritis Peer-reviewed

    P. A. Alvarado-Vazquez, C. E. Morado-Urbina, G. Castañeda-Corral, R. I. Acosta-Gonzalez, H. Kitaura, K. Kimura, T. Takano-Yamamoto, J. M. Jiménez-Andrade

    Neuroscience Letters　584　39-44　2015/01/01

    DOI： 10.1016/j.neulet.2014.09.053 　

    ISSN： 0304-3940

    eISSN： 1872-7972

  66. Effect of macrophage colony-stimulating factor receptor c-Fms antibody on lipopolysaccharide-induced pathological osteoclastogenesis and bone resorption Invited

    Keisuke Kimura, Hideki Kitaura, Masahiko Ishida, Zaki Hakami, Jafari Saeed, Haruki Sugisawa, Teruko Takano-Yamamoto

    Interface Oral Health Science 2014: Innovative Research on Biosis-Abiosis Intelligent Interface　259-267　2015/01/01

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-55192-8_22 　

  67. The role of Th1 cytokines on mechanical loading-induced osteoclastogenesis and bone resorption Invited

    Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Zaki Hakami, Jafari Saeed, Haruki Sugisawa, Teruko Takano-Yamamoto

    Interface Oral Health Science 2014: Innovative Research on Biosis-Abiosis Intelligent Interface　269-279　2015/01/01

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-55192-8_23 　

  68. Histochemical Characteristics of Glycoproteins During Rat Palatine Gland Development Peer-reviewed

    Zaki Hakami, Hideki Kitaura, Shiho Honma, Satoshi Wakisaka, Teruko Takano-Yamamoto

    Interface Oral Health Science 2014　183-192　2015

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-55192-8_15 　

  69. 東北大学矯正歯科における長期咬合管理について Invited

    北浦 英樹, 山本 照子

    東北矯正歯科学会雑誌　22　(1)　51-55　2014/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  70. Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway

    Kenji Hoshi, Harumi Kawaki, Ichiro Takahashi, Nobuo Takeshita, Masahiro Seiryu, Sakhr A. Murshid, Taisuke Masuda, Takahisa Anada, Ryushi Kato, Hideki Kitaura, Osamu Suzuki, Teruko Takano-Yamamoto

    Transactions of Japanese Society for Medical and Biological Engineering　52　O-237　2014/08/17

    DOI： 10.11239/jsmbe.52.O-237 　

    ISSN： 1881-4379

    eISSN： 1347-443X

  71. Inhibitory effect of neutralization of macrophage colony-stimulating factor in mechanical loading-induced osteoclastogenesis and odontoclastogenesis

    Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Zaki Hakami, Saeed Jafari, Haruki Sugisawa, Harika Kohara, Masako Yoshimatsu, Teruko Takano-Yamamoto T

    Transactions of Japanese Society for Medical and Biological Engineering　52　O-208　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-208 　

    ISSN： 1881-4379

    eISSN： 1347-443X

  72. Lectin histochemistry of palatine glands in the developing rat International-journal Peer-reviewed

    Zaki Hakami, Hideki Kitaura, Shiho Honma, Satoshi Wakisaka, Teruko Takano-Yamamoto

    Acta Histochemica　116　(4)　596-605　2014/05

    DOI： 10.1016/j.acthis.2013.11.002 　

    ISSN： 0065-1281

    eISSN： 1618-0372

  73. An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model Peer-reviewed

    K. Kimura, H. Kitaura, T. Fujii, M. Ishida, Z. W. Hakami, T. Takano-Yamamoto

    ORAL DISEASES　20　(3)　319-324　2014/04

    DOI： 10.1111/odi.12117 　

    ISSN： 1354-523X

    eISSN： 1601-0825

  74. An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model Peer-reviewed

    K. Kimura, H. Kitaura, T. Fujii, M. Ishida, Zw Hakami, T. Takano-Yamamoto

    Oral Diseases　20　(3)　319-324　2014/04

    DOI： 10.1111/odi.12117 　

    ISSN： 1354-523X

    eISSN： 1601-0825

  75. Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane International-journal Invited Peer-reviewed

    Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Haruki Sugisawa, Haruka Kohara, Masako Yoshimatsu, Teruko Takano-Yamamoto

    The Scientific World Journal　2014　617032-617032　2014

    DOI： 10.1155/2014/617032 　

    ISSN： 1537-744X

    eISSN： 1537-744X

  76. Relationship between sleep bruxism and sleep respiratory events in patients with obstructive sleep apnea syndrome International-journal Peer-reviewed

    Hisashi Hosoya, Hideki Kitaura, Takashi Hashimoto, Mau Ito, Masayuki Kinbara, Toru Deguchi, Toshiya Irokawa, Noriko Ohisa, Hiromasa Ogawa, Teruko Takano-Yamamoto

    Sleep and Breathing　18　(4)　837-844　2014

    DOI： 10.1007/s11325-014-0953-5 　

    ISSN： 1520-9512

    eISSN： 1522-1709

  77. Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway. International-journal Peer-reviewed

    Kenji Hoshi, Harumi Kawaki, Ichiro Takahashi, Nobuo Takeshita, Masahiro Seiryu, Sakhr A Murshid, Taisuke Masuda, Takahisa Anada, Ryushi Kato, Hideki Kitaura, Osamu Suzuki, Teruko Takano-Yamamoto

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research　29　(5)　1244-57　2014

    DOI： 10.1002/jbmr.2115 　

    ISSN： 0884-0431

    eISSN： 1523-4681

  78. Combination of tumor necrosis factor α and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo International-journal Peer-reviewed

    Kazuhiro Yokota, Kojiro Sato, Takashi Miyazaki, Hideki Kitaura, Hisako Kayama, Fumihiko Miyoshi, Yasuto Araki, Yuji Akiyama, Kiyoshi Takeda, Toshihide Mimura

    Arthritis and Rheumatology　66　(1)　121-129　2014/01

    DOI： 10.1002/art.38218 　

    ISSN： 2326-5191

    eISSN： 2326-5205

  79. 東北大学矯正歯科における最近の臨床調査 Invited

    21　(1)　69-72　2013/12

    Publisher:

    ISSN： 1340-2668

  80. Expression of pituitary adenylate cyclase-activating peptide (PACAP) and pac1 in the periodontal ligament after tooth luxation International-journal Peer-reviewed

    Sayako Nonaka, Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Teruko Takano-Yamamoto

    Cellular and Molecular Neurobiology　33　(7)　885-892　2013/10

    DOI： 10.1007/s10571-013-9953-4 　

    ISSN： 0272-4340

    eISSN： 1573-6830

  81. Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo International-journal Invited Peer-reviewed

    Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Haruka Kohara, Masako Yoshimatsu, Teruko Takano-Yamamoto

    Clinical and Developmental Immunology　2013　181849-181849　2013

    DOI： 10.1155/2013/181849 　

    ISSN： 1740-2522

    eISSN： 1740-2530

  82. 東北大学および宮城県における震災後の矯正歯科患者の実態調査

    北浦 英樹

    東北矯正歯科学会雑誌　20　(1)　104-105　2012/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  83. 顎関節症、シザーズバイトおよび叢生を伴う骨格性I級アングルII級の顔面非対称に対しアンカースクリューを用いて改善した症例 Peer-reviewed

    千田透子, 出口徹, 渡辺壽子, 北浦英樹, 山本照子

    東北矯正歯科学会雑誌　20　(1)　31-45　2012/12

    Publisher:

    ISSN： 1340-2668

  84. IL-4 inhibits TNF-α-mediated osteoclast formation by inhibition of RANKL expression in TNF-α-activated stromal cells and direct inhibition of TNF-α-activated osteoclast precursors via a T-cell-independent mechanism in vivo International-journal Peer-reviewed

    Toshiya Fujii, Hideki Kitaura, Keisuke Kimura, Zaki Weli Hakami, Teruko Takano-Yamamoto

    Bone　51　(4)　771-780　2012/10

    DOI： 10.1016/j.bone.2012.06.024 　

    ISSN： 8756-3282

  85. Inhibitory effect of interferon-γ on experimental tooth movement in mice International-journal Peer-reviewed

    Haruka Kohara, Hideki Kitaura, Masako Yoshimatsu, Yuji Fujimura, Yukiko Morita, Toshiko Eguchi, Noriaki Yoshida

    Journal of Interferon and Cytokine Research　32　(9)　426-431　2012/09/01

    DOI： 10.1089/jir.2011.0124 　

    ISSN： 1079-9907

    eISSN： 1557-7465

  86. Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass International-journal Peer-reviewed

    Ritsuko Masuyama, Atsuko Mizuno, Hisato Komori, Hiroshi Kajiya, Atsushi Uekawa, Hideki Kitaura, Koji Okabe, Kaname Ohyama, Toshihisa Komori

    Journal of Bone and Mineral Research　27　(8)　1708-1721　2012/08

    DOI： 10.1002/jbmr.1629 　

    ISSN： 0884-0431

    eISSN： 1523-4681

  87. 東北大学病院における東日本大震災後の矯正歯科患者の実態調査 Peer-reviewed

    北浦英樹, 出口徹, 池田悦子, 竹下信郎, 橋本隆志, 清流正弘, 伊藤麻卯, 木村桂介, 藤井俊哉, 石田匡彦, 山本照子

    東北大学歯学雑誌　31　(1)　1-7　2012/06

    Publisher:

    ISSN： 0287-3915

  88. Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo International-journal Peer-reviewed

    Keisuke Kimura, Hideki Kitaura, Toshiya Fujii, Zaki Weli Hakami, Teruko Takano-Yamamoto

    FEMS Immunology and Medical Microbiology　64　(2)　219-227　2012/03

    DOI： 10.1111/j.1574-695X.2011.00888.x 　

    ISSN： 0928-8244

    eISSN： 1574-695X

  89. Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice International-journal Peer-reviewed

    Masako Yoshimatsu, Hideki Kitaura, Yuji Fujimura, Haruka Kohara, Yukiko Morita, Toshiko Eguchi, Noriaki Yoshida

    Archives of Oral Biology　57　(1)　36-43　2012/01

    DOI： 10.1016/j.archoralbio.2011.07.006 　

    ISSN： 0003-9969

  90. Comparative proteomic analysis of a cytosolic fraction from β3 integrin-deficient cells International-journal Peer-reviewed

    Jason A. Bush, Hideki Kitaura, Yuliang Ma, Steven L. Teitelbaum, F. Patrick Ross, Jeffrey W. Smith

    Cancer Genomics and Proteomics　9　(1)　1-13　2012

    ISSN： 1109-6535

    eISSN： 1790-6245

  91. IL-12-mediated and IL-18-mediated Nitric oxide-induced apoptosis of adherent bone marrow cells in TNF-α-induced osteoclast formation Invited

    Hideki Kitaura, Tomo Aonuma, Emiko Fukumoto, Keisuke Kimura, Toshiya Fujii, Zaki Weli Hakami, Teruko Takano-Yamamoto

    Interface Oral Health Science 2011　125-127　2012/01/01

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-54070-0-29 　

  92. デンタルインプラントを利用して矯正治療を行った成人反対咬合症例 Peer-reviewed

    江口俊子, 北浦英樹, 藤村裕治, 吉松昌子, 小原悠, 西村裕美, 吉田教明

    九矯歯誌　7　(1)　23-32　2011/12

    Publisher:

    ISSN： 1880-9596

  93. IL-12- and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells International-journal Peer-reviewed

    Hideki Kitaura, Yuji Fujimura, Masako Yoshimatsu, Haruka Kohara, Yukiko Morita, Tomo Aonuma, Emiko Fukumoto, Ritsuko Masuyama, Noriaki Yoshida, Teruko Takano-Yamamoto

    Calcified Tissue International　89　(1)　65-73　2011/07

    DOI： 10.1007/s00223-011-9494-0 　

    ISSN： 0171-967X

    eISSN： 1432-0827

  94. IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions International-journal Peer-reviewed

    Haruka Kohara, Hideki Kitaura, Yuji Fujimura, Masako Yoshimatsu, Yukiko Morita, Toshiko Eguchi, Ritsuko Masuyama, Noriaki Yoshida

    Immunology Letters　137　(1-2)　53-61　2011/06/30

    DOI： 10.1016/j.imlet.2011.02.017 　

    ISSN： 0165-2478

  95. Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. International-journal Peer-reviewed

    Takeshi Moriishi, Zenjiro Maruyama, Ryo Fukuyama, Masako Ito, Toshihiro Miyazaki, Hideki Kitaura, Hidetake Ohnishi, Tatsuya Furuichi, Yosuke Kawai, Ritsuko Masuyama, Hisato Komori, Kenji Takada, Hiroshi Kawaguchi, Toshihisa Komori

    PloS one　6　(11)　e27487　2011

    DOI： 10.1371/journal.pone.0027487 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  96. 上顎左側側切歯欠損、上下顎叢生、正中離開を伴う片側性口唇口蓋症例

    北浦 英樹, 藤村 裕治, 吉松 昌子, 江口 俊子, 小原 悠, 佛坂 斉祉, 平野 明喜, 吉田 教明

    九州矯正歯科学会雑誌　6　(1)　89-96　2010/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  97. IL-18 inhibits TNF-α-induced osteoclastogenesis possibly via a T cell-independent mechanism in synergy with IL-12 in vivo International-journal Peer-reviewed

    Yukiko Morita, Hideki Kitaura, Masako Yoshimatsu, Yuji Fujimura, Haruka Kohara, Toshiko Eguchi, Noriaki Yoshida

    Calcified Tissue International　86　(3)　242-248　2010/03

    DOI： 10.1007/s00223-010-9335-6 　

    ISSN： 0171-967X

  98. 上顎左側側切歯欠損，上下顎叢生，正中離開を伴う片側性唇顎口蓋裂症例 Peer-reviewed

    北浦英樹, 藤村裕治, 吉松昌子, 江口俊子, 小原悠, 佛坂斉祉, 平野明喜, 吉田教明

    九矯歯誌　6　(1)　87-94　2010

  99. Influence of bisphosphonates on orthodontic tooth movement in mice International-journal Peer-reviewed

    Yuji Fujimura, Hideki Kitaura, Masako Yoshimatsu, Toshiko Eguchi, Haruka Kohara, Yukiko Morita, Noriaki Yoshida

    European Journal of Orthodontics　31　(6)　572-577　2009/12

    DOI： 10.1093/ejo/cjp068 　

    ISSN： 0141-5387

    eISSN： 1460-2210

  100. 下顎枝垂直骨切り術（IVRO）による外科矯正の術後管理 Peer-reviewed

    吉松昌子, 北浦英樹, 飛田尚慶, 朝比奈泉, 吉田教明

    九矯歯誌　5　(1)　49-54　2009/12

    Publisher:

    ISSN： 1880-9596

  101. IL-12 inhibits TNF-α induced osteoclastogenesis via a T cell-independent mechanism in vivo International-journal Peer-reviewed

    Masako Yoshimatsu, Hideki Kitaura, Yuji Fujimura, Toshiko Eguchi, Haruka Kohara, Yukiko Morita, Noriaki Yoshida

    Bone　45　(5)　1010-1016　2009/11

    DOI： 10.1016/j.bone.2009.07.079 　

    ISSN： 8756-3282

  102. An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice International-journal Peer-reviewed

    Hideki Kitaura, Yuji Fujimura, Masako Yoshimatsu, Toshiko Eguchi, Haruka Kohara, Insan Jang, Yukiko Morita, Noriaki Yoshida

    Angle Orthodontist　79　(5)　835-841　2009/09

    DOI： 10.2319/080708-412.1 　

    ISSN： 0003-3219

    eISSN： 0003-3219

  103. 正貌における咬合平面傾斜と顔面対称性の関係に関する検討 Peer-reviewed

    田崎春奈, 北浦英樹, 江口俊子, 小原悠, Jang In-San, 吉田教明

    九矯歯誌　4　(1)　39-44　2008/12

    Publisher:

    ISSN： 1880-9596

  104. 上顎第一小臼歯および上下顎第一大臼歯抜去を行った著しい叢生を伴う上顎前突症例 Peer-reviewed

    藤村裕治, 北浦英樹, 吉松昌子, 江口俊子, 小原悠, 吉田教明

    九矯歯誌　4　(1)　65-72　2008/12

    Publisher:

    ISSN： 1880-9596

  105. RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice International-journal

    Sergio Vaira, Muhammad Alhawagri, Imani Anwisye, Hideki Kitaura, Roberta Faccio, Deborah Veis Novack

    Journal of Clinical Investigation　118　(6)　2088-2097　2008/06/02

    DOI： 10.1172/JCI33392 　

    ISSN： 0021-9738

    eISSN： 1558-8238

  106. Application of a mini-screw at the maxillary tubercle for treatment of maxillary protrusion Peer-reviewed

    Noriko Nakao, Hideki Kitaura, Yoshiyuki Koga, Noriaki Yoshida

    Orthodontic Waves　67　(2)　72-80　2008/06

    DOI： 10.1016/j.odw.2007.11.021 　

    ISSN： 1344-0241

  107. An anti-c-Fms antibody inhibits orthodontic tooth movement Peer-reviewed

    H. Kitaura, M. Yoshimatsu, Y. Fujimura, T. Eguchi, H. Kohara, A. Yamaguchi, N. Yoshida

    Journal of Dental Research　87　(4)　396-400　2008/04

    DOI： 10.1177/154405910808700405 　

    ISSN： 0022-0345

  108. RANKL activates an apoptotic JNK pathway opposed by RelA/p65. Peer-reviewed

    Vaira S, Alhawagri M, Anwisye I, Kitaura H, Faccio R, Novack DV

    J. Clin. Invest.　118　(6)　2088-2097　2008

    DOI： 10.1172/JCI33392 　

  109. 長崎大学医学部・歯学部附属病院歯並び・噛み合わせ治療室におけるインプラント併用矯正患者の統計学的観察 Peer-reviewed

    吉松昌子, 北浦英樹, 藤村裕治, 江口俊子, 小原悠, 吉田教明

    九矯歯誌　3　(1)　9-14　2007/12

    Publisher:

    ISSN： 1880-9596

  110. 学校歯科健診における中学生の歯列・咬合・顎関節検診結果と推移について Peer-reviewed

    中尾紀子, 北浦英樹, 古賀義之, 吉田教明

    九矯歯誌　3　(1)　1-8　2007/12

    Publisher:

    ISSN： 1880-9596

  111. Glucocorticoids and the osteoclast International-journal Peer-reviewed

    Hyun Ju Kim, Haibo Zhao, Hideki Kitaura, Sandip Bhattacharyya, Judson A. Brewer, Louis J. Muglia, F. Patrick Ross, Steven L. Teitelbaum

    Annals of the New York Academy of Sciences　1116　335-339　2007/11

    DOI： 10.1196/annals.1402.057 　

    ISSN： 0077-8923

    eISSN： 1749-6632

  112. Treatment of a patient with metal hypersensitivity after orthognathic surgery International-journal Peer-reviewed

    Hideki Kitaura, Yuji Fujimura, Noriko Nakao, Toshiko Eguchi, Noriaki Yoshida

    Angle Orthodontist　77　(5)　923-930　2007/09

    DOI： 10.2319/082306-344 　

    ISSN： 0003-3219

    eISSN： 0003-3219

  113. Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency International-journal Peer-reviewed

    Zenjiro Maruyama, Carolina A. Yoshida, Tatsuya Furuichi, Norio Amizuka, Masako Ito, Ryo Fukuyama, Toshihiro Miyazaki, Hideki Kitaura, Kouhei Nakamura, Takashi Fujita, Naoko Kanatani, Takeshi Moriishi, Kei Yamana, Wenguang Liu, Hiroshi Kawaguchi, Kozo Nakamura, Toshihisa Komori

    Developmental Dynamics　236　(7)　1876-1890　2007/07

    DOI： 10.1002/dvdy.21187 　

    ISSN： 1058-8388

    eISSN： 1097-0177

  114. Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption International-journal Peer-reviewed

    Wei Zou, Hideki Kitaura, Jennifer Reeve, Fanxin Long, Victor L.J. Tybulewicz, Sanford J. Shattil, Mark H. Ginsberg, F. Patrick Ross, Steven L. Teitelbaum

    Journal of Cell Biology　176　(6)　877-888　2007/03/12

    DOI： 10.1083/jcb.200611083 　

    ISSN： 0021-9525

    eISSN： 0021-9525

  115. Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide International-journal Peer-reviewed

    Jennifer E. Sprague, Hideki Kitaura, Wei Zou, Yunpeng Ye, Samuel Achilefu, Katherine N. Weilbaecher, Steven L. Teitelbaum, Carolyn J. Anderson

    Journal of Nuclear Medicine　48　(2)　311-318　2007/02/01

    ISSN： 0161-5505

  116. Dexamethsone suppresses bone formation via the osteoclast International-journal Peer-reviewed

    Hyun Ju Kim, Haibo Zhao, Hideki Kitaura, Sandip Bhattacharyya, Judson A. Brewer, Louis J. Muglia, F. Patrick Ross, Steven L. Teitelbaum

    Advances in Experimental Medicine and Biology　602　43-46　2007

    DOI： 10.1007/978-0-387-72009-8_5 　

    ISSN： 0065-2598

  117. SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27 International-journal Peer-reviewed

    Ping Zhou, Hideki Kitaura, Steven L. Teitelbaum, Gerald Krystal, F. Patrick Ross, Sunao Takeshita

    Journal of Immunology　177　(12)　8777-8784　2006/12/15

    DOI： 10.4049/jimmunol.177.12.8777 　

    ISSN： 0022-1767

  118. 学校歯科健診における矯正歯科医による歯列・咬合・顎関節検診結果について Peer-reviewed

    中尾紀子, 北浦英樹, 古賀義之, 吉田教明

    九矯歯誌　2　(1)　15-24　2006/12

    Publisher:

    ISSN： 1880-9596

  119. IL-18 induces apoptosis of adherent bone marrow cells in TNF-α mediated osteoclast formation in synergy with IL-12 International-journal Peer-reviewed

    Hideki Kitaura, Mutsuhito Tatamiya, Noriko Nagata, Yuji Fujimura, Toshiko Eguchi, Noriaki Yoshida, Koji Nakayama

    Immunology Letters　107　(1)　22-31　2006/09/15

    DOI： 10.1016/j.imlet.2006.06.005 　

    ISSN： 0165-2478

  120. Glucocorticoids suppress bone formation via the osteoclast. Peer-reviewed

    H. J. Kim, H. Zhao, H. Kitaura, S. Bhattachayya, J. A. Brewer, L. J. Muglia, F. P. Ross, S. L. Teitelbaum

    JOURNAL OF BONE AND MINERAL RESEARCH　21　(8)　S121-S121　2006/09

    DOI： 10.1172/JCI28084 　

    ISSN： 0884-0431

  121. Glucocorticoids suppress bone formation via the osteoclast International-journal

    Hyun Ju Kim, Haibo Zhao, Hideki Kitaura, Sandip Bhattacharyya, Judson A. Brewer, Louis J. Muglia, F. Patrick Ross, Steven L. Teitelbaum

    Journal of Clinical Investigation　116　(8)　2152-2160　2006/08/01

    DOI： 10.1172/JCI28084 　

    ISSN： 0021-9738

    eISSN： 1558-8238

  122. The hemoglobin receptor protein of Porphyromonas gingivalis inhibits receptor activator NF-κB ligand-induced osteoclastogenesis from bone marrow macrophages International-journal Peer-reviewed

    Yuji Fujimura, Hitoshi Hotokezaka, Naoya Ohara, Mariko Naito, Eiko Sakai, Mamiko Yoshimura, Yuka Narita, Hideki Kitaura, Noriaki Yoshida, Koji Nakayama

    Infection and Immunity　74　(5)　2544-2551　2006/05

    DOI： 10.1128/IAI.74.5.2544-2551.2006 　

    ISSN： 0019-9567

  123. Experimental model of tooth movement by orthodontic force in mice and its application to tumor necrosis factor receptor-deficient mice Peer-reviewed

    Masako Yoshimatsu, Yasuaki Shibata, Hideki Kitaura, Xin Chang, Takeshi Moriishi, Fumio Hashimoto, Noriaki Yoshida, Akira Yamaguchi

    Journal of Bone and Mineral Metabolism　24　(1)　20-27　2006/01

    DOI： 10.1007/s00774-005-0641-4 　

    ISSN： 0914-8779

  124. Critical role of β3 integrin in experimental postmenopausal osteoporosis International-journal

    Haibo Zhao, Hideki Kitaura, Mark S. Sands, F. Patrick Ross, Steven L. Teitelbaum, Deborah Veis Novack

    Journal of Bone and Mineral Research　20　(12)　2116-2123　2005/12

    DOI： 10.1359/JBMR.050724 　

    ISSN： 0884-0431

  125. M-CSF mediates TNF-induced inflammatory osteolysis International-journal Peer-reviewed

    Hideki Kitaura, Ping Zhou, Hyun Ju Kim, Deborah V. Novack, F. Patrick Ross, Steven L. Teitelbaum

    Journal of Clinical Investigation　115　(12)　3418-3427　2005/12

    DOI： 10.1172/JCI26132 　

    ISSN： 0021-9738

    eISSN： 1558-8238

  126. FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner International-journal Peer-reviewed

    Shuting Bai, Hideki Kitaura, Haibo Zhao, Ju Chen, Judith M. Müller, Roland Schüle, Bryant Darnay, Deborah V. Novack, F. Patrick Ross, Steven L. Teitelbaum

    Journal of Clinical Investigation　115　(10)　2742-2751　2005/10

    DOI： 10.1172/JCI24921 　

    ISSN： 0021-9738

  127. NF-κB-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis International-journal Peer-reviewed

    Kunihiko Aya, Muhammad Alhawagri, Amanda Hagen-Stapleton, Hideki Kitaura, Osami Kanagawa, Deborah Veis Novack

    Journal of Clinical Investigation　115　(7)　1848-1854　2005/07

    DOI： 10.1172/JCI23763 　

    ISSN： 0021-9738

  128. IL-1 mediates TNF-induced osteoclastogenesis International-journal Peer-reviewed

    Shi Wei, Hideki Kitaura, Ping Zhou, F. Patrick Ross, Steven L. Teitelbaum

    Journal of Clinical Investigation　115　(2)　282-290　2005/02

    DOI： 10.1172/JCI200523394 　

    ISSN： 0021-9738

  129. Serine752 of the osteoclast b3 integrin mediates experimental post-menopausal osteoporosis. Peer-reviewed

    Zhao H, Kitaura H, Sands MS, Ross FP, Teitelbaum SL, Novack DV

    J. Bone Miner. Res.　20　(12)　2116-2123　2005

  130. An antibacterial surface on dental implants, based on the photocatalytic bactericidal effect International-journal Peer-reviewed

    Naoki Suketa, Takashi Sawase, Hideki Kitaura, Mariko Naito, Koumei Baba, Koji Nakayama, Ann Wennerberg, Mitsuru Atsuta

    Clinical Implant Dentistry and Related Research　7　(2)　105-111　2005

    DOI： 10.1111/j.1708-8208.2005.tb00053.x 　

    ISSN： 1523-0899

    eISSN： 1708-8208

  131. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-α-induced osteoclastogenesis in vivo International-journal Peer-reviewed

    Hideki Kitaura, Mark S. Sands, Kunihiko Aya, Ping Zhou, Teruhisa Hirayama, Brian Uthgenannt, Shi Wei, Sunao Takeshita, Deborah Veis Novack, Matthew J. Silva, Yousef Abu-Amer, F. Patrick Ross, Steven L. Teitelbaum

    Journal of Immunology　173　(8)　4838-4846　2004/10/15

    DOI： 10.4049/jimmunol.173.8.4838 　

    ISSN： 0022-1767

  132. Inhibition of RANKL-induced osteoclast formation in mouse bone marrow cells by IL-12: Involvement of IFN-γ possibly induced from non-T cell population International-journal Peer-reviewed

    Noriko Nagata, Hideki Kitaura, Noriaki Yoshida, Koji Nakayama

    Bone　33　(4)　721-732　2003/10/01

    DOI： 10.1016/S8756-3282(03)00213-8 　

    ISSN： 8756-3282

  133. Interleukin-4 directly inhibits tumor necrosis factor-α-mediated osteoclast formation in mouse bone marrow macrophages International-journal Peer-reviewed

    Hideki Kitaura, Noriko Nagata, Yuji Fujimura, Hitoshi Hotokezaka, Mutsuhito Tatamiya, Noriko Nakao, Noriaki Yoshida, Koji Nakayama

    Immunology Letters　88　(3)　193-198　2003/09/08

    DOI： 10.1016/S0165-2478(03)00082-8 　

    ISSN： 0165-2478

  134. 矯正用エラスティックに対する強酸性電解水による滅菌及び劣化の検討

    中尾 紀子, 北浦 英樹, 吉田 教明

    日本口腔機能水学会誌　4　(1)　3-7　2003/03

    Publisher: 日本口腔機能水学会

  135. Induced sensitization to nickel in guinea pigs immunized with mycobacteria by injection of purified protein derivative with nickel Peer-reviewed

    H. Kitaura, N. Nakao, N. Yoshida, T. Yamada

    New Microbiologica　26　(1)　101-108　2003/01

    ISSN： 1121-7138

  136. 矯正エラスティックに対する強酸性電解水による滅菌および劣化の検討 Peer-reviewed

    中尾紀子, 北浦英樹, 吉田教明

    口腔機水誌　4　3-8　2003

  137. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 Cells into osteoclast-like cells International-journal Peer-reviewed

    Hitoshi Hotokezaka, Eiko Sakai, Kazuhiro Kanaoka, Kan Saito, Ken ichiro Matsuo, Hideki Kitaura, Noriaki Yoshida, Koji Nakayama

    Journal of Biological Chemistry　277　(49)　47366-47372　2002/12/06

    DOI： 10.1074/jbc.M208284200 　

    ISSN： 0021-9258

  138. Three-Dimensional Cephalometry Using Helical Computer Tomography: Measurement Error Caused by Head Inclination International-journal Peer-reviewed

    Kumiko Togashi, Hideki Kitaura, Koichi Yonetsu, Noriaki Yoshida, Takashi Nakamura

    Angle Orthodontist　72　(6)　513-520　2002/12

    ISSN： 0003-3219

  139. Effect of IL-12 on TNF-α-mediated osteoclast formation in bone marrow cells: Apoptosis mediated by Fas/Fas ligand interaction International-journal Peer-reviewed

    Hideki Kitaura, Noriko Nagata, Yuji Fujimura, Hitoshi Hotokezaka, Noriaki Yoshida, Koji Nakayama

    Journal of Immunology　169　(9)　4732-4738　2002/11/01

    DOI： 10.4049/jimmunol.169.9.4732 　

    ISSN： 0022-1767

  140. Changed activation of HIV-1 LTR in monocytoid cells by mycobacteria with temporal progression of infection Peer-reviewed

    H. Kitaura, N. Ohara, N. Nakao, N. Yoshida, T. Yamada

    New Microbiologica　25　(3)　357-361　2002/07

    ISSN： 1121-7138

  141. 矯正用材料に対する強電解酸性水の影響について -DMG testを用いてのNi溶出の解析- Peer-reviewed

    永田礼子, 北浦英樹, 中尾紀子, 藤村祐治, 吉田教明

    口腔機水誌　3　(1)　19-24　2002/03

    Publisher:

  142. The effects of strongly acid electrolytic water on orthodontic materials -Analysis for nickel release using the dimethylglyoxime spot test-

    N Nagata, H Kitaura, N Nakao, Y Fujimura, N Yoshida

    J Jpn Soc Oral Funct Water　3　(1)　19-24　2002

  143. Cloning and sequencing of the groESL homologue from Porphyromonas gingivalis.

    Hotokezaka H, Sakai E, Kanaoka K, Saito K, Matsuo K, Kitaura H, Yoshida N, Nakayama K

    Biochimica et Biophysica Acta　277　(49)　47366-47372.　2002

  144. Analysis of orthodontic wires for nickel release using dimethylglyoxime spot test in vitro and in vivo. Peer-reviewed

    Nakao N, Kitaura H, Yoshida N

    Orthod. Waves.　61　(6)　478-481　2002

    Publisher:

    ISSN： 1344-0241

    More details Close

    Recently, much attention has been focused on allergic diseases thought to be caused by dental metals. Orthodontic materials contain metals that can induce metal allergies, and it is possible that metal ions are eluted from orthodontic materials by the corrosive action of saliva, electrolytes in food debris, and acids produced by bacteria. Nickel (Ni), in particular, is thought to be a typical antigen for metal allergy ; the numbers of patients with Ni allergy are increasing. In this study, we evaluated the release of Ni from orthodontic wires in various acids as the products of oral bacteria using the dimethylgyoxime test (DMG test), which detects the release of Ni. Ni release from nickel-titanium (Ni-Ti) wire occurred in hydrochloric, lactic, formic, phosphoric, and acetic acids. Stainless steel and Ni-Ti coated with Au wires released Ni in hydrochloric and formic acids, respectively. Cobalt chromium (Co-Cr) wire released Ni when placed in hydrochloric, formic and acetic acids. Further, wires that had been placed in oral cavities during orthodontic treatment were analyzed for Ni release by the DMG test. Though just one in 75 Ni-Ti rectangular wires and 2 in 66 Co-Cr rectangular wires released Ni, careful consideration of the materials used is necessary in the treatment of patients with allergies, since the orthodontic wires can release Ni.

  145. 矯正装置に対する強電解酸性水の影響について DMG testによるニッケル溶出の評価

    北浦 英樹, 永田 礼子, 安達 紀子, 小林 和英

    日本口腔機能水学会誌　2　(1)　97-98　2001/03

    Publisher: 日本口腔機能水学会

  146. 矯正用ワイヤーに対する強電解酸性水の影響について -強電解酸性水によるNi溶出について- Peer-reviewed

    北浦英樹, 安達紀子, 永田礼子, 小林和英

    口腔機水誌　2　(1)　11-17　2001/03

    Publisher:

  147. Metal elements contained in nonmetallic orthodontic materials. Peer-reviewed

    Kitaura H, Nakao N, Yoshida N

    Orthod. Waves.　60　(6)　414-417　2001

    Publisher:

    ISSN： 1344-0241

    More details Close

    Recent years have seen metal-related allergies become an increasing problem. Allergy to orthodontic materials has been reported. Therefore, the need for countermeasures to allergies to orthodontic metallic materials has increased. Also, there is a possibility that metal elements are included in the nonmetallic materials. However, the components of nonmetallic orthodontic materials are not being examined. We analysed nonmetallic orthodontic materials for metal elements using an X-ray fluorescence spectroscope. It was found that a small amount of metal element was included in nonmetallic materials. When the patient with a metal allergy is treated, a sufficient examination of the nonmetallic materials is also necessary.

  148. TNF-α-mediated activation of HIV-1 LTR in monocytoid cells by mycobacteria Peer-reviewed

    Hideki Kitaura, Naoya Ohara, Kazuhide Kobayashi, Takeshi Yamada

    FEMS Immunology and Medical Microbiology　31　(2)　97-103　2001

    DOI： 10.1016/S0928-8244(01)00249-8 　

    ISSN： 0928-8244

  149. TNF-α-mediated multiplication of human immunodeficiency virus in chronically infected monocytoid cells by mycobacterial infection Peer-reviewed

    Hideki Kitaura, Naoya Ohara, Kazuhide Kobayashi, Takeshi Yamada

    APMIS　109　(7-8)　533-540　2001

    DOI： 10.1111/j.1600-0463.2001.907807.x 　

    ISSN： 0903-4641

  150. Standardization of 3-D CT measurements for length and angles by matrix transformation in the 3-D coordinate system Peer-reviewed

    Hideki Kitaura, Koichi Yonetsu, Hideki Kitamori, Kazuhide Kobayashi, Takashi Nakamura

    Cleft Palate-Craniofacial Journal　37　(4)　349-356　2000/07

    DOI： 10.1597/1545-1569(2000)037<0349:SODCMF>2.3.CO;2 　

    ISSN： 1055-6656

  151. Quantitative analysis of the surface elements of orthodontic metal materials using an X-ray fluorescence spectroscope Peer-reviewed

    ADACHI Noriko, KITAURA Hideki, IKEDA Miwa, KOBAYASHI Kazuhide

    Orthodontic Waves　59　(2)　128-137　2000/04/25

    Publisher:

    ISSN： 1344-0241

  152. Analysis of the release of nickel from orthodontic wines using the dimethylglyoxime spot test: in vitro and in vivo study

    N Adachi, H Kitaura, M Ikeda, K Kobayashi

    Orthodontic Waves　59　(2)　128-137　2000

  153. Fibronectin-binding proteins secreted by mycobacterium avium Peer-reviewed

    Hideki Kitaura, Naoya Ohara, Mariko Naito, Kazuhide Kobayashi, Takeshi Yamada

    APMIS　108　(9)　558-564　2000

    DOI： 10.1034/j.1600-0463.2000.d01-97.x 　

    ISSN： 0903-4641

  154. 矯正歯科患者に対する金属アレルギーに関する意識調査 Peer-reviewed

    池田美和, 北浦英樹, 井口修一郎, 小林和英

    西日矯歯誌　44　(1)　109-116　1999/08

    Publisher:

    ISSN： 0911-2839

  155. ガム咀嚼時咀嚼筋筋活動、顎運動記録の正規化およびデータベース化 Peer-reviewed

    井口修一郎, 古賀義之, 北浦英樹, 吉田憲弘, 畳屋睦人, 小村弘斉, 池田美和, 小林和英

    西日矯歯誌　44　(1)　96-108　1999/08

    Publisher:

    ISSN： 0911-2839

  156. Species-specific B-cell epitope on the C-terminal region of the α antigen from Mycobacterium intracellulare in mice Peer-reviewed

    Hideki Kitaura, Naoya Ohara, Mariko Naito, Kazuhide Kobayashi, Takeshi Yamada

    Veterinary Microbiology　65　(1)　9-19　1999/02/23

    DOI： 10.1016/S0378-1135(98)00280-6 　

    ISSN： 0378-1135

  157. Ribosomal protein L7 included in tuberculin purified protein derivative (PPD) is a major heat-resistant protein inducing strong delayed-type hypersensitivity Peer-reviewed

    H. Kitaura, M. Kinomoto, Takeshi Yamada

    Scandinavian Journal of Immunology　50　(6)　580-587　1999

    DOI： 10.1046/j.1365-3083.1999.00630.x 　

    ISSN： 0300-9475

  158. The effects of strongly acid electrolytic water used for sterilization on the cutting properties of the orthodontic cutting instruments Peer-reviewed

    KITAURA Hideki, KOGA Yoshiyuki, IKEDA Miwa, IGUCHI Shuichirou, KOBAYASI Kazuhide

    日矯歯誌　57　(5)　291-298　1998/11/01

    Publisher:

    ISSN： 1344-0241

  159. The 16-kDa α-crystallin-like protein of Mycobacterium bovis BCG is produced under conditions of oxygen deficiency and is associated with ribosomes Peer-reviewed

    Y. Tabira, N. Ohara, N. Ohara, H. Kitaura, S. Matsumoto, M. Naito, T. Yamada

    Research in Microbiology　149　(4)　255-264　1998/04

    DOI： 10.1016/S0923-2508(98)80301-X 　

    ISSN： 0923-2508

  160. 矯正用器具に対する強酸性電解水滅菌の有用性の検討 -強酸性電解水とオートクレーブの比較- Peer-reviewed

    北浦英樹, 安達紀子, 池田美和, 井口修一郎, 古賀義之, 吉田憲弘, 畳屋睦人, 小林和英

    西日矯歯誌　42　(2)　108-116　1998/02

    Publisher:

    ISSN： 0911-2839

  161. Evaluation of strongly acid electrolytic water for orthodontic instruments -Comparison of strongly acid electrolytic water and autoclave-

    Kitaura H, Adachi N, Ikeda M, Iguchi S, Koga Y, Yoshida N, Tatamiya M, Kobayashi K

    J Nishi-Nippon Orthod Soc　42　(2)　108-115　1998

  162. Serological analysis of C-terminal region of α antigen from Mycobacterium avium-intracellulare complex and Mycobacterium tuberculosis Peer-reviewed

    Hideki Kitaura, Naoya Ohara, Mariko Naito, Kazuhide Kobayashi, Takeshi Yamada

    APMIS　106　(9)　893-900　1998

    DOI： 10.1111/j.1699-0463.1998.tb00236.x 　

    ISSN： 0903-4641

  163. PCR amplification of 16S ribosomal RNA gene for detection of bacterial infection in root canal. Peer-reviewed

    Kitaura H, Ohara N, Matsuo T, Kobayashi K, Yamada T

    Dentistry in Japan　34　21-23　1998

  164. Analysis of the genes encoding the antigen 85 complex and MPT51 from Mycobacterium avium Peer-reviewed

    Naoya Ohara, Naoko Ohara-Wada, Hideki Kitaura, Takeshi Nishiyama, Sohkichi Matsumoto, Takeshi Yamada

    Infection and Immunity　65　(9)　3680-3685　1997/09

    DOI： 10.1128/iai.65.9.3680-3685.1997 　

    ISSN： 0019-9567

  165. 口腔習癖を伴う上顎前突症の治療例 -機能的顎矯正装置の可及的終日使用の効果- Peer-reviewed

    北浦英樹, 井口修一郎, 古賀義之, 吉田憲弘, 畳屋睦人, 小林和英

    西日矯歯誌　42　(1)　19-28　1997/08

    Publisher:

    ISSN： 0911-2839

  166. Application of strongly acid electrolytic water to orthodontics -Corrosive action on orthodontic materials and instruments- Peer-reviewed

    KITAURA Hideki, IWANUMA Keniji, YOSHIDA Norihiro, IGUCHI Shuichirou, KOBAYASI Kazuhide

    日矯歯誌　56　(3)　141-148　1997/06/01

    Publisher:

    ISSN： 0021-454X

  167. Knowledge and attitudes of Japanese dental health care workers towards HIV-related disease Peer-reviewed

    H. Kitaura, N. Adachi, K. Kobayashi, T. Yamada

    Journal of Dentistry　25　(3-4)　279-283　1997

    DOI： 10.1016/S0300-5712(96)00030-9 　

    ISSN： 0300-5712

  168. Cloning and sequencing of an MPB70 homologue corresponding to MPB83 from Mycobacterium bovis BCG Peer-reviewed

    T. Matsuo, H. Matsuo, N. Ohara, S. Matsumoto, H. Kitaura, A. Mizuno, T. Yamada

    Scandinavian Journal of Immunology　43　(5)　483-489　1996

    DOI： 10.1046/j.1365-3083.1996.d01-68.x 　

    ISSN： 0300-9475

  169. An internal control for the rapid detection of mycobacteria by amplification of a segment of the gene encoding alpha antigen. Peer-reviewed

    H. Kitaura, N. Ohara, T. Matsuo, T. Yamada

    The new microbiologica : official journal of the Italian Society for Medical, Odontoiatric, and Clinical Microbiology (SIMMOC)　18　(4)　429-433　1995/10

    ISSN： 1121-7138

  170. Characterization of the Gene Encoding the MPB51, One of the Major Secreted Protein Antigens of Mycobacterium bovis BCG, and Identification of the Secreted Protein Closely Related to the Fibronectin Binding 85 Complex International-journal Peer-reviewed

    N. OHARA, H. KITAURA, H. HOTOKEZAKA, T. NISHIYAMA, N. WADA, S. MATSUMOTO, T. MATSUO, M. NAITO, T. YAMADA

    Scandinavian Journal of Immunology　41　(5)　433-442　1995/05

    DOI： 10.1111/j.1365-3083.1995.tb03589.x 　

    ISSN： 0300-9475

    eISSN： 1365-3083

  171. 1. The role of some cellular components of bacterial parasites in determining the incidence of tuberculosis: Studies on mycobacterial antigens, with special reference to mycobacterial immunoreactive ribosomal and secreted proteins

    T. Yamada, N. Ohara, S. Matsumoto, T. Matsuo, H. Kitaura, H. Yukitake, N. Wada, T. Nishiyama, M. Naito, M. Kinomoto, M. Kimura

    Kekkaku　70　(11)　639-644　1995

    ISSN： 0022-9776

  172. Differential transcription of the MPB7O genes in two major groups of Mycobacterium bovis BCG substrains Peer-reviewed

    T. Matsuo, S. Matsumoto, N. Ohara, H. Kitaura, A. Mizuno, T. Yamada

    Microbiology　141　(7)　1601-1607　1995

    DOI： 10.1099/13500872-141-7-1601 　

    ISSN： 1350-0872

  173. Biochemical and Immunological Characterization of Ribosomal Fraction and Culture Filtrate from Mycobacterium Peer-reviewed

    Yamada T, Ohara N, Wada N, Matsumoto S, Yukitake E, Matsuo T, Kitaura H, Takano M, Nishiyama T, Nomaguchi H, Matsuo M

    Actinomycetol　9　(2)　228-235　1995

    Publisher: The Society for Actinomycetes Japan

    DOI： 10.3209/saj.9_228 　

    ISSN： 0914-5818

  174. Biochemical and immunological characterization of ribosomal fraction and culture filtrate from BCG Peer-reviewed

    Yamada T, Ohara N, Matsumoto S, Matsuo T, Kitaura H, Takano M, Nishiyama T, Yukitake E, Miyazaki R, Nomaguchi H, Mastuoka M

    Proceedings to 30th Joint Reserch Conference on Leprosy and Tuberculosis　30　246-249　1995

  175. ウインドウズデータベースソフト（Microsoft Access）を応用したセファロ分析システムの開発 Peer-reviewed

    井口修一郎, 柿崎陽介, 古堅信, 北浦英樹, 小林和英

    西日矯歯誌　39　132-141　1994

  176. Study of a antigen from Mycobacterium intracellulare and use of PCR for the rapid identification of Mycobacterium intracellulare. Peer-reviewed

    Kitaura H, Ohara N, Naito M, Nishiyama T, Wada N, Matsumoto S, Matsuo T, Hotokezaka H, Hayashida H, Kobayashi K, Yamada T

    Procceedings to 4th Western Pacific Congress on Chemotherapy and Infectious Diseases　10　(3)　585-586　1994

    DOI： 10.1006/bbrc.1993.2417 　

  177. Structure and immunological properties of major secreted antigen a and related antigens of mycobacteria. Peer-reviewed

    Ohara N, Kitaura H, Naito M, Nishiyama T, Wada N, Matsumoto S, Matsuo T, Hotokezaka H, Hayashida H, Yamada T

    Procceedings to 4th Western Pacifuc Congress on Chemotherapy and Infectious Diseases　10　(3)　628-629　1994

  178. Regulation of MPB70 gene expression between two major BCG substrains. Peer-reviewed

    Matsuo T, Ohara N, Matsumoto S, Kitaura H, Naito M, Wada N, Nishiyama T, Hotokezaka H, Hayashida H, Mizuno A, Yamada T

    Procceedings to 4th Western Pacifuc Congress on Chemotherapy and Infectious Diseases　10　(3)　590-591　1994

  179. Cloning, sequencing and expression of the gene for α antigen from mycobacterium intracellulare and use of PCR for the rapid identification of mycobacterium intracellulare Peer-reviewed

    Hideki Kitaura, Naoya Ohara, Takemitsu Matsuo, Hiromichi Tasaka, Kazuhide Kobayashi, Takeshi Yamada

    Biochemical and Biophysical Research Communications　196　(3)　1466-1473　1993/11/15

    DOI： 10.1006/bbrc.1993.2417 　

    ISSN： 0006-291X

    eISSN： 1090-2104

  180. 外科的矯正治療に伴う顎運動の変化 −顔面非対称を伴う下顎前症例について− Peer-reviewed

    舟越純治, 井口修一郎, 北浦英樹, 小林和英

    西日矯歯誌　37　18-29　1992

Show all ︎Show first 5

Misc. 226

  1. 歯科矯正用アンカースクリューを用いた開咬症例の矯正歯科治療

    野口隆弘, 小倉裕樹, 北浦英樹, 溝口到

    東北矯正歯科学会雑誌　31　(1)　45-47　2023/12

  2. PTFE複合めっきによる歯科矯正用ワイヤーの摩擦特性への影響

    沼崎 研人, 北浦 英樹, 高橋 正敏, 高田 雄京, 溝口 到

    日本歯科理工学会誌　42　(Special Issue WINTER)　9-9　2023/12

    Publisher: (一社)日本歯科理工学会

    ISSN： 1884-4421

  3. Azilsartan attenuates LPS-induced osteoclastogenesis and bone resorption via inhibition of TNF-α expression in macrophages.

    Fan Z, Kitaura H, Ren J, Ohori F, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Narita K, Lin A, Mizoguchi I

    第82回日本矯正歯科学会大会プログラム・抄録集　2023/11

  4. Analysis of DHA effects on osteoclastogenesis through GPR120 in a bone marrow chimeric mouse model.

    Ma J, Kitaura H, Ohori F, Noguchi T, Marahleh A, Kinjo R, Kanou K, Mizoguchi I

    第82回日本矯正歯科学会大会プログラム・抄録集　2023/11

  5. The transcriptomic landscape of hyperglycemic osteocytes.

    2023/11

  6. ネクロプトーシスした骨細胞が矯正学的歯の移動に伴う破骨細胞形成に与える影響

    大堀文俊, 北浦英樹, 野口隆弘, Marahleh Aseel、Ma Jinghan, 加納佳与子, 三浦まり子, 成田昂平, 溝口到

    第82回日本矯正歯科学会大会プログラム・抄録集　2023/11

  7. Angiotensin-(1-7)はLPS刺激マクロファージにおけるTNF-αの発現を減少して破骨細胞形成と骨吸収を抑制する

    Ren Jiayi, 北浦英樹, 野口隆弘, 大堀文俊, Marahleh Aseel, Ma Jinghan, 加納佳代子, 三浦まり子, 成田昂平, 溝口到

    第82回日本矯正歯科学会大会プログラム・抄録集　2023/11

  8. 低酸素環境における骨細胞様細胞(MLO-Y4細胞)のRNAシーケンス解析

    成田昂平, 北浦英樹, 大堀文俊, 野口隆弘, マラーレ アジール, 加納佳与子, マ ジンハン, 三浦まり子, 溝口到

    第82回日本矯正歯科学会大会プログラム・抄録集　2023/11

  9. 老齢マウスにおける矯正学的歯の移動および破骨細胞形成の解析とそのメカニズムの解明

    加納佳与子, 北浦英樹, 野口隆弘, 大堀文俊, Aseel Marahleh, 金城里阿, Jinghan Ma, 三浦まり子, 成田昂平, 溝口到

    第82回日本矯正歯科学会大会プログラム・抄録集　2023/11

  10. ヒストンメチル化酵素SET7/9が破骨細胞分化に及ぼす影響について

    野口隆弘、北浦英樹、大堀文俊、Marahleh Aseel、Ma Jinghan、加納佳与子、三浦まり子、成田昂平、溝口到

    第82回日本矯正歯科学会大会プログラム・抄録集　2023/11

  11. RNA sequencing analysis of osteoclast related genes in osteocyte-like cell line cultured in hypoxic environment.

    Narita K, Kitaura H, Ohori F, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Ren J, Mizoguchi I

    JOURNAL OF BONE AND MINERAL RESEARCH　2023/10

  12. Angiotensin-(1-7) attenuated LPS-induced osteoclastogenesis and bone resorption via inhibiting the activation of MAPK pathway in macrophages.

    Ren J, Kitaura H, Noguchi T, Ohori F, Marahleh A, Ma J, Kanou K, Miura M, Narita K, Mizoguchi I

    JOURNAL OF BONE AND MINERAL RESEARCH　2023/10

  13. Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and bone resorption through GPR120.

    Ma J, Kitaura H, Ohori F, Noguchi T, Marahleh A, Kinjo R, Kanou K, Mizoguchi I

    JOURNAL OF BONE AND MINERAL RESEARCH　2023/10

  14. Effect of DAMPs released from osteocyte necroptosis on osteoclastogenesis.

    Ohori F, Kitaura H, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Ren J, Narita K, Ren J, Mizoguchi I

    JOURNAL OF BONE AND MINERAL RESEARCH　2023/10

  15. Hyperglycemia induces extensive alternative splicing changes in osteocytes with minimal transcriptional alterations.

    Marahleh A, Rashad S, Kitaura H, Ren J, Ohori F, Noguchi T, Mizoguchi I

    JOURNAL OF BONE AND MINERAL RESEARCH　2023/10

  16. キメラマウスを用いた矯正学的歯の移動促進のマイクロオステオパーフォレーションの解析

    金城里阿, 北浦英樹, 大堀文俊, 野口隆弘, マラーレ アジール, 奈良靖彦, 加納佳与子, マ ジンハン, 三浦まり子, 溝口到

    日本矯正歯科学会大会プログラム・抄録集 81回 2022年10月　2023/10

  17. TNF-αの骨細胞における破骨細胞分化関連遺伝子発現のRNAシーケンス

    三浦まり子, 北浦英樹, 大堀文俊, 野口隆弘, マラーレ アジール, 奈良靖彦, 金城里阿, 加納佳与子, マ ジンハン, 溝口到

    日本矯正歯科学会大会プログラム・抄録集 81回 2022年10月　2022/10

  18. Gli1陽性歯根膜細胞の実験的歯牙移動時における骨芽細胞分化機構

    関有里, 建部廣明, 北浦英樹, 飯嶋雅弘, 溝口 到, 細矢明宏

    日本矯正歯科学会大会プログラム・抄録集 81回　2022/10

  19. 骨細胞のネクロプトーシスにより放出される核内因子IL-33の骨代謝への影響

    大堀 文俊, 北浦 英樹, 小川 紗衣香, 野口 隆弘, Marahleh Aseel, 奈良 靖彦, Pramusita Adya, 金城 里阿, Ma Jinghan, 加納 佳与子, 溝口 到

    東北大学歯学雑誌　39/40/41　(2/1-2/1)　47-47　2022/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  20. 窒化チタン(TiN)コーティングによる金属アレルギー患者用ワイヤーの開発

    伊藤 新, 北浦 英樹, 杉澤 晴紀, 野口 隆弘, 大堀 文俊, 溝口 到

    東北大学歯学雑誌　39/40/41　(2/1-2/1)　52-52　2022/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  21. Investigation of the Effect of Anti-c-fms Antibody on Osteoclast formation in Ovariectomized Mice

    Yasuhiko Nara, Hideki Kitaura, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi

    JOURNAL OF BONE AND MINERAL RESEARCH　37　124-124　2022/02

    ISSN： 0884-0431

    eISSN： 1523-4681

  22. Salt-Sensitive Hypertension Induces Systemic Bone Resorption Via Upregulation of Angiotensin II Type 1 Receptor in Osteoblast

    Adya Pramusita, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Ria Kinjo, Itaru Mizoguchi

    JOURNAL OF BONE AND MINERAL RESEARCH　37　95-95　2022/02

    ISSN： 0884-0431

    eISSN： 1523-4681

  23. 東北大学病院矯正歯科における先天疾患症例について

    佐々木 聡史, 北浦 英樹, 溝口 到

    東北矯正歯科学会雑誌　29　(1)　61-62　2021/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  24. 開咬症例における矯正治療と外科的矯正治療の適応 歯科矯正用アンカースクリューを用いた上顎大臼歯の移動様式

    北浦 英樹, 福永 智広, 清流 正弘

    日本顎変形症学会雑誌　31　(4)　226-229　2021/12

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  25. 上顎骨前方牽引装置を用いて骨格的改善を行った軟骨無形成症を伴う骨格性III級症例

    野口 隆弘, 北浦 英樹, 溝口 到

    東北矯正歯科学会雑誌　29　(1)　78-79　2021/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  26. 矯正学的歯の移動における骨細胞のネクロプトーシスの検出

    大堀 文俊, 北浦 英樹, 小川 紗衣香, 野口 隆弘, マラーレ・アジール, 奈良 靖彦, アディア・プラムスィタ, 金城 里阿, 加納 佳与子, 溝口 到

    日本矯正歯科学会大会プログラム・抄録集　80回　146-146　2021/11

    Publisher: (公社)日本矯正歯科学会

  27. マイクロオステオパーフォレーションによる矯正学的歯の移動促進におけるTNF-αの役割

    金城 里阿, 北浦 英樹, 小川 紗衣香, 大堀 文俊, 野口 隆弘, アジール・マラーレ, 奈良 靖彦, アディア・プラムスィタ, 溝口 到

    日本矯正歯科学会大会プログラム・抄録集　80回　147-147　2021/11

    Publisher: (公社)日本矯正歯科学会

  28. 抗RANKL抗体の矯正学的歯の移動への効果について

    吉松 昌子, 北浦 英樹, 森田 幸子, 中村 琢也, 鵜飼 孝

    日本矯正歯科学会大会プログラム・抄録集　80回　148-148　2021/11

    Publisher: (公社)日本矯正歯科学会

  29. 矯正学的歯の移動時に出現する骨芽細胞はGli1陽性歯根膜細胞に由来する

    関 有里, 建部 廣明, 北浦 英樹, 飯嶋 雅弘, 溝口 到, 細矢 明宏

    日本矯正歯科学会大会プログラム・抄録集　80回　151-151　2021/11

    Publisher: (公社)日本矯正歯科学会

  30. 卵巣摘出マウスにおける矯正学的歯の移動と歯根吸収について

    奈良 靖彦, 北浦 英樹, 小川 紗衣香, 大堀 文俊, 野口 隆弘, マラーレ・アジール, アディア・プラムスィタ, 金城 里阿, マー・ジンハン, 加納 佳与子, 溝口 到

    日本矯正歯科学会大会プログラム・抄録集　80回　152-152　2021/11

    Publisher: (公社)日本矯正歯科学会

  31. 開咬症例における歯科矯正用アンカースクリューを用いた矯正治療と外科的矯正治療の後戻りの比較

    小倉 裕樹, 北浦 英樹, 大柳 俊仁, 清流 正弘, 真山 敦, 伊藤 新, 溝口 到

    日本矯正歯科学会大会プログラム・抄録集　80回　185-185　2021/11

    Publisher: (公社)日本矯正歯科学会

  32. Marfan症候群を有する患者に対し全身状態のモニタリングのもとで矯正歯科治療を行った一症例

    佐々木 聡史, 北浦 英樹, 溝口 到

    日本矯正歯科学会大会プログラム・抄録集　80回　223-223　2021/11

    Publisher: (公社)日本矯正歯科学会

  33. 東北大学病院矯正歯科における10年間の先天性疾患症例の実態調査

    佐々木 聡史, 北浦 英樹, 前田 敏博, 小川 紗衣香, 小倉 裕樹, 亀田 真衣, 金城 里阿, 茂見 翔平, 沼崎 研人, 溝口 到

    東北矯正歯科学会雑誌　28　(1)　57-58　2020/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  34. Investigation of the Molecular Mechanism of TNF-alpha-Induced RANK on Osteoclast Precursors in Orthodontic Tooth Movement

    Takahiro Noguchi, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi

    JOURNAL OF BONE AND MINERAL RESEARCH　35　93-93　2020/11

    ISSN： 0884-0431

    eISSN： 1523-4681

  35. Investigation of Effect of IL-33 on TNF-alpha-Induced Osteoclast Formation and Orthodontic Tooth Movement

    Fumitoshi Ohori, Hideki Kitaura, Saika Ogawa, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi

    JOURNAL OF BONE AND MINERAL RESEARCH　35　94-94　2020/11

    ISSN： 0884-0431

    eISSN： 1523-4681

  36. TNF-alpha Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation

    Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Akiko Kishikawa, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi

    JOURNAL OF BONE AND MINERAL RESEARCH　34　238-238　2019/12

    ISSN： 0884-0431

    eISSN： 1523-4681

  37. TNF-alpha stimulates the expression of RANK during orthodontic tooth movement

    Takahiro Noguchi, Hideki Kitaura, Akiko Kishikawa, Saika Ogawa, Jiawei Qi, Wei-Ren Shen, Fumitoshi Ohori, Aseel Marahleh, Yasuhiko Nara, Itaru Mizoguchi

    JOURNAL OF BONE AND MINERAL RESEARCH　34　236-236　2019/12

    ISSN： 0884-0431

    eISSN： 1523-4681

  38. Investigation of the contribution of osteoclastgenesis relevant cells to osteoclast formation in orthodontic tooth movement

    Saika Ogawa, Hideki Kitaura, Aseel Marahleh, Akiko Kishikawa, Jiawei Qi, Wei-Ren Shen, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi

    JOURNAL OF BONE AND MINERAL RESEARCH　34　236-236　2019/12

    ISSN： 0884-0431

    eISSN： 1523-4681

  39. Investigation of the Role of TNF-alpha-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement

    Fumitoshi Ohori, Hideki Kitaura, Aseel Marahleh, Akiko Kishikawa, Saika Ogawa, Jiawei Qi, Wei-Ren Shen, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi

    JOURNAL OF BONE AND MINERAL RESEARCH　34　239-239　2019/12

    ISSN： 0884-0431

    eISSN： 1523-4681

  40. 矯正学的歯の移動におけるTNF-αは骨細胞のsclerostin発現を増強し破骨細胞形成を誘導する

    大堀 文俊, 北浦 英樹, マラーレ・アジール, 岸川 明子, 小川 紗衣香, セイ・カイ, 沈 威任, 野口 隆弘, 奈良 靖彦, 溝口 到

    日本矯正歯科学会大会プログラム・抄録集　78回　130-130　2019/11

    Publisher: (公社)日本矯正歯科学会

  41. 矯正学的歯の移動時にTNF-αはNF-κB経路を介してRANK発現を増加させることで破骨細胞分化を促進する

    野口 隆弘, 北浦 英樹, 岸川 明子, 小川 紗衣香, セイ・カイ, 沈 威任, 大堀 文俊, マラーレ・アジール, 奈良 靖彦, 溝口 到

    日本矯正歯科学会大会プログラム・抄録集　78回　176-176　2019/11

    Publisher: (公社)日本矯正歯科学会

  42. Clinical investigation of the orthodontic anchor screws in Tohoku University Hospital

    Atsushi mayama, Masahiro seiryu, Toru deguchi, Masayuki kinbara, Masaya iwasaki, Yohei kera, Shunro miyashita, Daisuke seki, Nobuo takeshita, Tomohiro fukunaga, Hideki kitaura, Teruko yamamoto

    132-132　2018/11

  43. 最近の矯正歯科における金属アレルギーについて

    北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　77回　175-175　2018/10

    Publisher: (公社)日本矯正歯科学会

  44. 破骨細胞形成、骨吸収および破骨細胞関連サイトカインの発現におけるDHAの影響についての検討

    岸川 明子, 木村 桂介, 小川 紗衣香, セイ・カイ, 沈 威任, 大堀 文俊, 野口 隆弘, マラーレ・アジール, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　77回　233-233　2018/10

    Publisher: (公社)日本矯正歯科学会

  45. CXCL12の破骨細胞形成、骨吸収および破骨細胞関連サイトカインの発現への影響についての検討

    島 和弘, 木村 桂介, 石田 匡彦, 岸川 明子, 小川 紗衣香, セイ・カイ, 沈 威任, 大堀 文俊, 野口 隆弘, マラーレ・アジール, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　77回　233-233　2018/10

    Publisher: (公社)日本矯正歯科学会

  46. 破骨細胞形成、骨吸収および破骨細胞関連サイトカインの発現への糖尿病治療薬DPP-4阻害剤の影響

    石田 匡彦, 沈 威任, 木村 桂介, 島 和弘, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　77回　234-234　2018/10

    Publisher: (公社)日本矯正歯科学会

  47. TNF-αによる骨細胞と矯正学的歯の移動におけるsclerostin発現解析

    大堀 文俊, 木村 桂介, 岸川 明子, 小川 紗衣香, セイ・カイ, 沈 威任, 野口 隆弘, マラーレ・アジール, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　77回　248-248　2018/10

    Publisher: (公社)日本矯正歯科学会

  48. TNF-αのRANK発現への影響および矯正学的歯の移動時のRANK発現について

    野口 隆弘, 木村 桂介, 岸川 明子, 小川 紗衣香, セイ・カイ, 沈 威任, 大堀 文俊, マラーレ・アジール, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　77回　250-250　2018/10

    Publisher: (公社)日本矯正歯科学会

  49. コーティング歯科矯正用ワイヤーの耐食性の解析

    木村 桂介, 井田 裕人, 石田 匡彦, 島 和弘, 岸川 明子, 小川 紗衣香, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　77回　257-257　2018/10

    Publisher: (公社)日本矯正歯科学会

  50. 東北大学病院矯正歯科における歯科矯正用アンカースクリューに関する臨床調査

    真山 敦, 清流 正弘, 出口 徹, 金原 正敬, 岩崎 将也, 解良 洋平, 宮下 俊郎, 関 大輔, 竹下 信郎, 福永 智広, 北浦 英樹, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　77回　268-268　2018/10

    Publisher: (公社)日本矯正歯科学会

  51. 外科的矯正歯科治療により形態および顎機能の改善が認められた前歯部開咬を伴う骨格性III級の下顎偏位症例

    関 大輔, 北浦 英樹, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　77回　333-333　2018/10

    Publisher: (公社)日本矯正歯科学会

  52. 東北大学病院矯正歯科における歯科矯正用アンカースクリューに関する臨床調査

    真山 敦, 清流 正弘, 出口 徹, 金原 正敬, 岩崎 将也, 解良 洋平, 宮下 俊郎, 関 大輔, 竹下 信郎, 福永 智広, 北浦 英樹, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　77回　268-268　2018/10

    Publisher: (公社)日本矯正歯科学会

  53. 東北大学病院矯正歯科における7年間の外科的矯正症例の動向調査 Peer-reviewed

    佐々木 聡史, 北浦 英樹, 大堀 文俊, 野口 隆弘, 小川 紗衣香, 真山 敦, 溝口 到

    東北大学歯学雑誌　36/37　(2/1)　37-40　2018/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  54. 歯科矯正用アンカースクリューを用いてデンタルコンペンセーションにより治療した予想外の晩期成長をした骨格性III級症例 Peer-reviewed

    宇佐見 香織, 北浦 英樹, 宍戸 香, 佐々木 聡, 溝口 到

    東北大学歯学雑誌　36/37　(2/1)　73-82　2018/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  55. 術前に片側性咀嚼筋腱・腱膜過形成症を呈した骨格性下顎後退症の一例

    奥山 喬介, 山内 健介, 片岡 良浩, 齊藤 志都, 鈴木 飛佳理, 山口 佳宏, 佐藤 工, 阿部 陽子, 野上 晋之介, 坂東 加南, 北浦 英樹, 高橋 哲

    日本顎変形症学会雑誌　28　(2)　140-140　2018/05

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  56. 歯科矯正用アンカースクリューを用いて水平的な咬合平面の傾斜を改善した正中離開症例 Peer-reviewed

    吉澤 光弘, 北浦 英樹, 福永 智広, 山本 照子

    東北矯正歯科学会雑誌　25　(1)　146-153　2017/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  57. 歯科矯正用アンカースクリューを用いた矯正歯科治療および臨床研究 Invited

    清流 正弘, 福永 智広, 北浦 英樹, 山本 照子

    東北矯正歯科学会雑誌　25　(1)　49-53　2017/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  58. 成人病と矯正治療について

    北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　76回　124-124　2017/10

    Publisher: (公社)日本矯正歯科学会

  59. TiNコーティングを施した歯科矯正用ワイヤーの摩擦力の検討

    杉澤 晴紀, 北浦 英樹, 上田 恭介, 木村 桂介, 石田 匡彦, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　76回　208-208　2017/10

    Publisher: (公社)日本矯正歯科学会

  60. 小脳髄芽腫の開頭手術後の左側顔面麻痺および側方性開咬を呈する症例

    佐々木 聡史, 北浦 英樹, 岩崎 将也, 原 真美子, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　76回　283-283　2017/10

    Publisher: (公社)日本矯正歯科学会

  61. 破骨細胞形成および骨吸収に対する脂肪細胞に発現するケモカインCXCL12の作用の検討

    島 和弘, 木村 桂介, 石田 匡彦, 杉澤 晴紀, 越智 由美子, 岸川 明子, セイ・カイ, 沈 威任, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　76回　182-182　2017/10

    Publisher: (公社)日本矯正歯科学会

  62. 脂肪酸受容体GPR120の破骨細胞形成および骨吸収との関連性の検討

    木村 桂介, 石田 匡彦, 島 和弘, 杉澤 晴紀, 越智 由美子, 岸川 明子, 小川 紗衣香, セイ・カイ, 沈 威任, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　76回　182-182　2017/10

    Publisher: (公社)日本矯正歯科学会

  63. 糖尿病治療薬DPP-4阻害薬による破骨細胞形成および骨吸収への影響について

    石田 匡彦, 木村 桂介, 島 和弘, 沈 威任, 北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　76回　183-183　2017/10

    Publisher: (公社)日本矯正歯科学会

  64. Runx2+/-マウスの矯正的歯の移動の牽引側における骨芽細胞の増殖および分化のRunx2/mTORC2シグナルの役割

    青沼智, 玉村長都, 福永智広, 酒井雄一, 北浦英樹, 竹下信郎, 山城隆, 山本照子

    日本矯正歯科学会大会プログラム・抄録集　76回　185-185　2017/10

    Publisher: (公社)日本矯正歯科学会

  65. Runx2+/-マウスの矯正的歯の移動の牽引側における骨芽細胞の増殖および分化機構にRunx2/mTORC2シグナルが関与する Peer-reviewed

    青沼 智, 福永 智広, 北浦 英樹, 竹下 信郎, 山城 隆, 山本 照子

    日本骨代謝学会学術集会プログラム抄録集　35回　157-157　2017/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 1349-0761

  66. 3.11 東日本大震災

    北浦英樹

    東北矯正歯科学会の記憶　27-35　2017

  67. 破骨細胞形成および骨吸収に対するIL-37の作用の検討

    木村 桂介, 北浦 英樹, 石田 匡彦, 杉澤 晴紀, 越智 由美子, 岸川 明子, セイ・カイ, ジャファリ・サイード, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　75回　190-190　2016/11

    Publisher: (公社)日本矯正歯科学会

  68. 矯正学的歯の移動における破歯細胞形成および歯根吸収へのTNF-αの関与について

    北浦 英樹, 木村 桂介, 石田 匡彦, 杉澤 晴紀, 越智 由美子, 岸川 明子, セイ・カイ, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　75回　191-191　2016/11

    Publisher: (公社)日本矯正歯科学会

  69. 矯正学的歯の移動による破骨細胞形成に対するIL-18の影響およびIL-12との相互作用の検討

    越智 由美子, 北浦 英樹, 木村 桂介, 石田 匡彦, 杉澤 晴紀, ジャファリ・サイード, 岸川 明子, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　74回　183-183　2015/11

    Publisher: (公社)日本矯正歯科学会

  70. 矯正学的歯の移動における破骨細胞形成に関して骨髄移植を利用したキメラマウスによる解析

    北浦 英樹, 木村 桂介, 石田 匡彦, 杉澤 晴紀, 越智 由美子, ジャファリ・サイード, 岸川 明子, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　74回　189-189　2015/11

    Publisher: (公社)日本矯正歯科学会

  71. TiNコーティングを施した歯科矯正用ワイヤーの耐食性および機械的特性の検討

    杉澤 晴紀, 北浦 英樹, 上田 恭介, 木村 桂介, 石田 匡彦, 越智 由美子, 岸川 明子, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　74回　218-218　2015/11

    Publisher: (公社)日本矯正歯科学会

  72. 先天性疾患を伴う矯正歯科患者に対する生活の質のアンケート調査

    木村 桂介, 北浦 英樹, 黒木 毅, 石田 匡彦, 佐久間 知子, 長谷川 博, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　74回　234-234　2015/11

    Publisher: (公社)日本矯正歯科学会

  73. 顎顔面非対称の認識を評価する質問票の信頼性および妥当性の検討

    黒木 毅, 北浦 英樹, 木村 桂介, 石田 匡彦, 小林 孝敬, 出口 徹, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　74回　235-235　2015/11

    Publisher: (公社)日本矯正歯科学会

  74. Diamond Blackfan貧血を有する患者の頭蓋・顔面の特徴について

    解良 洋平, 北浦 英樹, 後藤 まき, 佐々木 聡史, 真山 敦, 伊藤 新, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　74回　308-308　2015/11

    Publisher: (公社)日本矯正歯科学会

  75. メカニカルストレスによる破骨細胞形成および骨吸収に対するIL-18の影響の解析

    越智 由美子, 北浦 英樹, 木村 桂介, 石田 匡彦, 岸川 明子, 山本 照子

    Journal of Oral Biosciences Supplement　2015　310-310　2015/09

    Publisher: (一社)歯科基礎医学会

    ISSN： 2187-2333

    eISSN： 2187-9109

  76. 口唇口蓋裂などの先天疾患を伴う矯正患者に対する顎口腔機能に関する問診票による調査

    木村 桂介, 北浦 英樹, 黒木 毅, 石田 匡彦, 佐久間 知子, 遠藤 学, 長谷川 博, 山本 照子

    日本口蓋裂学会雑誌　40　(2)　180-180　2015/04

    Publisher: (一社)日本口蓋裂学会

    ISSN： 0386-5185

    eISSN： 2186-5701

  77. LPSによる破骨細胞形成および骨吸収に対するMDPの影響の検討

    石田 匡彦, 北浦 英樹, 木村 桂介, 杉澤 晴紀, 高田 春比古, 山本 照子

    東北大学歯学雑誌　33　(2)　112-112　2014/12

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  78. LPSが引き起こす破骨細胞形成および骨吸収に対するMDPの作用の検討

    石田 匡彦, 北浦 英樹, 木村 桂介, ハカミ・ザキ・ウェリ, 杉澤 晴紀, サイード・ジャファリ, 高田 春比古, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　73回　193-193　2014/10

    Publisher: (公社)日本矯正歯科学会

  79. 前頭面からみた咬合平面傾斜が生活の質、顎機能の問題および顎顔面非対称に対する認識に及ぼす影響

    黒木 毅, 北浦 英樹, 出口 徹, 小林 考敬, 小原 紀明, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　73回　237-237　2014/10

    Publisher: (公社)日本矯正歯科学会

  80. 矯正学的歯の移動におけるIL-4の効果

    北浦 英樹, ハカミ・ザキ・ウェリ, 木村 桂介, 石田 匡彦, 杉澤 晴紀, 井田 裕人, サイード・ジャファリ, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　73回　192-192　2014/10

    Publisher: (公社)日本矯正歯科学会

  81. LPS誘導病的骨吸収に対するMDPの作用の検討

    石田 匡彦, 北浦 英樹, 木村 桂介, 杉澤 晴紀, 山本 照子

    日本骨代謝学会学術集会プログラム抄録集　32回　286-286　2014/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 1349-0761

  82. Muramyl dipeptide enhances Lipopolysaccharide-induced osteoclast formation and bone resorption by enhance of RANKL expression. Peer-reviewed

    Masahiko Ishida, Hideki Kitaura, Keisuke Kimura, Jafari Saeed, Haruki Sugisawa, Haruhiko Takada, Teruko Takano-Yamamoto

    JOURNAL OF BONE AND MINERAL RESEARCH　29　S158-S158　2014/02

    DOI： 10.1155/2015/132765 　

    ISSN： 0884-0431

    eISSN： 1523-4681

  83. Effect of IL-4 on mechanical loading-induced osteoclastogenesis and bone resorption. Peer-reviewed

    Hideki Kitaura, Zaki Hakami, Keisuke Kimura, Masahiko Ishida, Jafari Saeed, Haruki Sugisawa, Teruko Takano-Yamamoto

    JOURNAL OF BONE AND MINERAL RESEARCH　29　S282-S283　2014/02

    ISSN： 0884-0431

    eISSN： 1523-4681

  84. Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway. Peer-reviewed

    Hoshi Kenji, Kitaura Hideki, Suzuki Osamu, Kawaki Harumi, Takahashi Itiro, Takeshita Nobuo, Seiryu Masahiro, Sakhr Murshid, Masuda Taisuke, Anada Takahisa, Kato Ryushi

    Transactions of Japanese Society for Medical and Biological Engineering　52　(0)　O-237-O-238　2014

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.52.O-237 　

    ISSN： 1347-443X

  85. 顎顔面形態と睡眠の関連性について

    北浦 英樹

    東北矯正歯科学会雑誌　21　(1)　74-75　2013/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  86. 日中の眠気と上気道組織形態の関連性について

    千田 透子, Saeed Jafari, 北浦 英樹, 山本 照子

    東北矯正歯科学会雑誌　21　(1)　79-79　2013/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  87. 歯根吸収の生物学的メカニズムと制御について

    北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　72回　114-114　2013/10

    Publisher: (公社)日本矯正歯科学会

  88. 侵襲刺激後の神経ペプタイドpituitary adenylate cyclase activating polypeptide(PACAP)の歯根膜での発現

    北浦 英樹, 野中 紗弥子, 出口 徹, 木村 桂介, 石田 匡彦, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　72回　184-184　2013/10

    Publisher: (公社)日本矯正歯科学会

  89. LPS誘導破骨細胞形成および骨吸収に対するMDPの作用の検討

    石田 匡彦, 北浦 英樹, 木村 桂介, ハカミ・ザキ・ウェリ, 杉澤 晴紀, ジャファリ・サイード, 高田 春比古, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　72回　185-185　2013/10

    Publisher: (公社)日本矯正歯科学会

  90. マウス歯周病モデルを用いた破骨細胞形成および骨吸収に対する抗c-Fms抗体の抑制効果の検討

    木村 桂介, 北浦 英樹, 石田 匡彦, ハカミ・ザキ・ウェリ, 杉澤 晴紀, ジャファリ・サイード, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　72回　205-205　2013/10

    Publisher: (公社)日本矯正歯科学会

  91. 日中の眠気傾向と顎顔面形態の関連性について

    千田 透子, Jafari Saeed, 北浦 英樹, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　72回　224-224　2013/10

    Publisher: (公社)日本矯正歯科学会

  92. LPSによる破骨細胞形成に対するIL-12の抑制機序

    吉松 昌子, 北浦 英樹, 藤村 裕治, 小原 悠, 森田 幸子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　72回　180-180　2013/10

    Publisher: (公社)日本矯正歯科学会

  93. 矯正学的歯の移動時におこる歯根吸収に対するIFN-γの作用について

    小原 悠, 北浦 英樹, 吉松 昌子, 藤村 裕治, 森田 幸子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　72回　186-186　2013/10

    Publisher: (公社)日本矯正歯科学会

  94. LPSの破骨細胞形成に対するMDPの作用の検討

    石田 匡彦, 北浦 英樹, 木村 桂介, 高田 春比古, 山本 照子

    Journal of Oral Biosciences Supplement　2013　166-166　2013/09

    Publisher: (一社)歯科基礎医学会

    ISSN： 2187-2333

    eISSN： 2187-9109

  95. 歯根膜侵襲刺激後の神経ペプタイドpituitary adenylate cyclase activating polypeptide(PACAP)の発現について

    北浦 英樹, 木村 桂介, 石田 匡彦, 山本 照子

    Journal of Oral Biosciences Supplement　2013　178-178　2013/09

    Publisher: (一社)歯科基礎医学会

    ISSN： 2187-2333

    eISSN： 2187-9109

  96. 【最新の骨粗鬆症学-骨粗鬆症の最新知見】骨研究フロンティア 基礎から臨床まで 骨形成・骨吸収における関連因子の働き TNF-α Invited

    北浦 英樹

    日本臨床　71　(増刊2 最新の骨粗鬆症学)　141-145　2013/04

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  97. イオンプレーティング法を用いた金属アレルギー患者用矯正歯科材料の開発

    北浦 英樹, 木村 桂介, 藤井 俊哉, 石田 匡彦, 山本 照子

    東北矯正歯科学会雑誌　20　(1)　113-113　2012/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  98. 歯の移動のバイオロジーとバイオメカニクス 歯の移動の生物学的メカニズムと制御

    北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　71回　102-102　2012/09

    Publisher: (公社)日本矯正歯科学会

  99. IL-4のTNF-αによるRANKLおよびDC-STAMP発現のin vivoにおける抑制効果について

    北浦 英樹, 藤井 俊哉, 木村 桂介, 石田 匡彦, ハカミ・ザキ・ウェリ, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　71回　164-164　2012/09

    Publisher: (公社)日本矯正歯科学会

  100. M-CSF作用抑制による病的骨吸収に対する制御の検討

    木村 桂介, 北浦 英樹, 藤井 俊哉, 石田 匡彦, ハカミ・ザキ・ウェリ, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　71回　165-165　2012/09

    Publisher: (公社)日本矯正歯科学会

  101. 咬筋切除術を施した咬筋肥大症を伴う患者の機能的改善について

    鈴木 章裕, 北浦 英樹, 石田 匡彦, 橋本 隆志, 出口 徹, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　71回　270-270　2012/09

    Publisher: (公社)日本矯正歯科学会

  102. メカニカルストレスに対する歯根周囲組織におけるIFN-γの影響

    小原 悠, 北浦 英樹, 吉松 昌子, 藤村 裕治, 森田 幸子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　71回　161-161　2012/09

    Publisher: (公社)日本矯正歯科学会

  103. IL-12がLPS誘導破骨細胞形成に及ぼす影響

    吉松 昌子, 北浦 英樹, 藤村 裕治, 小原 悠, 森田 幸子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　71回　163-163　2012/09

    Publisher: (公社)日本矯正歯科学会

  104. IL-18による矯正学的歯の移動抑制作用におけるT細胞関与の検討

    森田 幸子, 北浦 英樹, 吉松 昌子, 藤村 裕治, 小原 悠, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　71回　167-167　2012/09

    Publisher: (公社)日本矯正歯科学会

  105. LPS誘導骨吸収に対する抗c-fms抗体の抑制作用の検討

    木村 桂介, 北浦 英樹, 石田 匡彦, Zaki Hakami, 山本 照子

    日本骨代謝学会学術集会プログラム抄録集　30回　240-240　2012/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 1349-0761

  106. TNF-αによる破骨細胞形成におけるIL-4の影響のin vivoでの検討

    北浦 英樹, 木村 桂介, 石田 匡彦, Zaki Hakami, 山本 照子

    日本骨代謝学会学術集会プログラム抄録集　30回　256-256　2012/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 1349-0761

  107. メカニカルストレスに対するIFN-γの発現およびその影響

    小原 悠, 北浦 英樹, 吉松 昌子, 森田 幸子, 藤村 裕治

    日本骨代謝学会学術集会プログラム抄録集　30回　240-240　2012/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 1349-0761

  108. IL-12がメカニカルストレスによる骨吸収に及ぼす影響

    吉松 昌子, 北浦 英樹, 小原 悠, 森田 幸子, 藤村 裕治

    日本骨代謝学会学術集会プログラム抄録集　30回　257-257　2012/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 1349-0761

  109. LPSにより誘導される骨吸収に対する抗c-fms抗体の抑制作用の検討

    木村 桂介, 北浦 英樹, 藤井 俊哉, 石田 匡彦, ハカミ・ザキ・ウェリ, 山本 照子

    東北大学歯学雑誌　31　(1)　63-63　2012/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  110. LPS誘導病的骨吸収に対するM-CSF中和抗体の作用の検討

    木村 桂介, 北浦 英樹, 藤井 俊哉, ハカミ・ザキ・ウェリ, 山本 照子

    Clinical Calcium　22　(5)　749-749　2012/04

    Publisher: (株)医薬ジャーナル社

    ISSN： 0917-5857

  111. IL-4のTNF-αによる破骨細胞形成に対する抑制効果についてのin vivoでの検討

    藤井 俊哉, 北浦 英樹, 木村 桂介, 山本 照子

    東北大学歯学雑誌　30　(2)　55-56　2011/12

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  112. 上顎左側中切歯および側切歯の萠出遅延に対し開窓・牽引を行った1症例

    藤村 裕治, 北浦 英樹, 吉松 昌子, 江口 俊子, 小原 悠, 六反田 裕美, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　70回　342-342　2011/10

    Publisher: (公社)日本矯正歯科学会

  113. IFN-γによるTNF-α誘導性破骨細胞の形成抑制効果

    小原 悠, 北浦 英樹, 吉松 昌子, 藤村 裕治, 森田 幸子, 増山 律子

    日本骨代謝学会学術集会プログラム抄録集　29回　241-241　2011/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 1349-0761

  114. TNF-αによる破骨細胞形成に対するIL-4の作用についてのin vivoでの検討

    藤井 俊哉, 北浦 英樹, 木村 桂介, ハカミ・ザキ・ウェリ, 山本 照子

    Clinical Calcium　21　(5)　756-756　2011/04

    Publisher: (株)医薬ジャーナル社

    ISSN： 0917-5857

  115. 機能的矯正装置における構成咬合について Invited

    北浦英樹

    小児歯科臨床　16　(3)　49-54　2011/03

    Publisher: 東京臨床出版(株)

    ISSN： 1341-1748

  116. TNF-αの骨代謝作用 Invited

    北浦英樹

    骨粗鬆症治療　10　(1)　10-14,8　2011/01

    Publisher: 先端医学社

    ISSN： 1347-572X

  117. 骨髄細胞でのTNF-aによる破骨細胞形成におけるIL-12およびIL-18によるアポトーシス誘導 Invited

    北浦英樹

    骨粗鬆症治療　10　(1)　8-8　2011

  118. 咬筋切除術を行ったAngle II級2類症例

    鈴木 章裕, 北浦 英樹, 橋本 隆志, 山本 照子

    東北矯正歯科学会雑誌　18　(1)　69-69　2010/12

    Publisher: 東北矯正歯科学会

    ISSN： 1340-2668

  119. イオンプレーティング法による矯正用金属コーティングの耐食性に関する検討

    北浦 英樹, 中尾 紀子, 藤田 剛史, 白石 孝信, 吉田 教明, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　69回　209-209　2010/09

    Publisher: (公社)日本矯正歯科学会

  120. 矯正学的歯の移動時の歯根吸収におけるIL-12の作用について

    吉松 昌子, 北浦 英樹, 藤村 裕治, 小原 悠, 森田 幸子, 江口 俊子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　69回　177-177　2010/09

    Publisher: (公社)日本矯正歯科学会

  121. 矯正学的歯の移動に対するIFN-γの発現およびその影響

    小原 悠, 北浦 英樹, 吉松 昌子, 藤村 裕治, 森田 幸子, 江口 俊子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　69回　179-179　2010/09

    Publisher: (公社)日本矯正歯科学会

  122. IL-18のTNF-α誘導破骨細胞形成抑制作用におけるT細胞の関与の検討

    森田 幸子, 北浦 英樹, 吉松 昌子, 藤村 裕治, 小原 悠, 江口 俊子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　69回　188-188　2010/09

    Publisher: (公社)日本矯正歯科学会

  123. 長崎大学における下顎枝垂直骨切り術(IVRO)による外科矯正の術後管理について

    北浦 英樹, 吉松 昌子, 藤村 裕治, 小原 悠, 江口 俊子, 田崎 春奈, 森田 幸子, 吉田 教明

    九州矯正歯科学会雑誌　5　(1)　64-64　2009/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  124. 下顎骨切りによる下顎骨の回転とその安定性について

    藤村 裕治, 北浦 英樹, 吉松 昌子, 田崎 春奈, 小原 悠, 吉田 教明

    九州矯正歯科学会雑誌　5　(1)　66-66　2009/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  125. 骨格性下顎前突症患者の術後正貌に対する垂直的顔面形態の影響

    田崎 春奈, 北浦 英樹, 吉松 昌子, 藤村 裕治, 小原 悠, 橋本 文生, 吉田 教明

    九州矯正歯科学会雑誌　5　(1)　67-67　2009/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  126. TNF-αによる破骨細胞形成に対してのT細胞のかかわりについての検討

    北浦 英樹, 藤村 裕治, 吉松 昌子, 小原 悠, 森田 幸子, 江口 俊子, 吉田 教明, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集　68回　166-166　2009/11

    Publisher: (公社)日本矯正歯科学会

  127. IL-18による矯正学的歯の移動と歯根吸収に及ぼす影響について

    森田 幸子, 北浦 英樹, 吉松 昌子, 藤村 裕治, 小原 悠, 江口 俊子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　68回　168-168　2009/11

    Publisher: (公社)日本矯正歯科学会

  128. IL-12の破骨細胞形成抑制作用におけるT細胞の関与ついて

    吉松 昌子, 北浦 英樹, 藤村 裕治, 小原 悠, 森田 幸子, 江口 俊子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　68回　169-169　2009/11

    Publisher: (公社)日本矯正歯科学会

  129. IFN-γ誘導性のNOによるM-CSF依存性破骨細胞前駆細胞の増殖抑制効果

    小原 悠, 北浦 英樹, 吉松 昌子, 藤村 裕治, 森田 幸子, 江口 俊子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　68回　183-183　2009/11

    Publisher: (公社)日本矯正歯科学会

  130. 下顎垂直骨切り術施行症例における下顎骨の術後位置変化についての検討

    田崎 春奈, 北浦 英樹, 吉松 昌子, 藤村 裕治, 小原 悠, 飛田 尚慶, 朝比奈 泉, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　68回　237-237　2009/11

    Publisher: (公社)日本矯正歯科学会

  131. TRPV4の活性型変異はカルシウムオシレーションを早発させ、破骨細胞分化を促進する

    増山 律子, 鍛治屋 浩, 北浦 英樹, 岡部 幸司, 小守 壽文

    日本骨代謝学会学術集会プログラム抄録集　27回　207-207　2009/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 1349-0761

  132. IVRO術後の顎関節偏位に関する研究 術前術後のCTによる分析

    飛田 尚慶, 北浦 英樹, 田崎 春名, 吉田 教明, 朝比奈 泉

    日本顎変形症学会雑誌　19　(2)　114-114　2009/05

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  133. 正面咬合平面傾斜と顔面対称性の評価の関連性に関する検討

    北浦 英樹, 田崎 春奈, 藤村 裕治, 吉松 昌子, 小原 悠, 飛田 尚慶, 朝比奈 泉, 吉田 教明

    日本顎変形症学会雑誌　19　(2)　103-103　2009/05

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  134. 骨格性下顎前突症患者の垂直的顔面形態の違いによる術後正貌の評価

    田崎 春奈, 北浦 英樹, 吉松 昌子, 藤村 裕治, 小原 悠, 飛田 尚慶, 朝比奈 泉, 吉田 教明

    日本顎変形症学会雑誌　19　(2)　108-108　2009/05

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  135. 下顎枝矢状分割術時の矢状面内での下顎骨の回転量と後戻りとの相関について

    藤村 裕治, 北浦 英樹, 吉松 昌子, 田崎 春奈, 小原 悠, 飛田 尚慶, 朝比奈 泉, 吉田 教明

    日本顎変形症学会雑誌　19　(2)　112-112　2009/05

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  136. 金属アレルギー患者用矯正材料の開発

    北浦 英樹, 中尾 紀子, 古賀 義之, 吉田 教明

    九州矯正歯科学会雑誌　4　(1)　140-140　2008/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  137. 下顎垂直骨切り術施行症例における上下中切歯と下顎骨の術後位置変化についての検討

    田崎 春奈, 芝崎 龍典, 中尾 紀子, 北浦 英樹, 佛坂 斉祉, 古賀 義之, 飛田 尚慶, 朝比奈 泉, 吉田 教明

    九州矯正歯科学会雑誌　4　(1)　144-144　2008/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  138. 矯正治療動物実験モデルにおけるビスフォスフォネートの影響

    藤村 裕治, 北浦 英樹, 吉松 昌子, 江口 俊子, 小原 悠, 吉田 教明

    九州矯正歯科学会雑誌　4　(1)　147-147　2008/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  139. 矯正学的歯の移動におけるIL-12の作用に対する分子生物学的解析

    吉松 昌子, 北浦 英樹, 藤村 裕治, 小原 悠, 江口 俊子, 吉田 教明

    九州矯正歯科学会雑誌　4　(1)　148-148　2008/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  140. 破骨細胞形成因子であるM-CSFに対するIFN-γの制御作用

    小原 悠, 北浦 英樹, 藤村 裕治, 吉松 昌子, 江口 俊子, 吉田 教明

    九州矯正歯科学会雑誌　4　(1)　148-148　2008/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  141. Recombinant Mouse M-CSF Receptor C-fms Inhibits TNF-alfa-induced Osteoclastogenesis.

    H. Kitaura, Y. Fujimura, M. Yoshimatsu, T. Eguchi, H. Kohara, Y. Morita, N. Yoshida

    JOURNAL OF BONE AND MINERAL RESEARCH　23　S401-S401　2008/09

    ISSN： 0884-0431

  142. IFN-gamma Inhibits TNF-alpha-induced Osteoclastogenesis in vitro and in vivo.

    H. Kohara, H. Kitaura, Y. Fujimura, M. Yoshimatsu, T. Eguchi, Y. Morita, N. Yoshida

    JOURNAL OF BONE AND MINERAL RESEARCH　23　S278-S278　2008/09

    ISSN： 0884-0431

  143. IL-12 Induces Apoptosis in TNF-alpha-mediated Osteoclastogenesis in vivo

    M. Yoshimatsu, H. Kitaura, Y. Fujimura, T. Eguchi, H. Kohara, Y. Morita, N. Yoshida

    JOURNAL OF BONE AND MINERAL RESEARCH　23　S166-S166　2008/09

    ISSN： 0884-0431

  144. IL-18による破骨細胞形成における抑制作用と矯正学的歯牙移動時のその効果について

    森田 幸子, 北浦 英樹, 吉松 昌子, 藤村 裕治, 江口 俊子, 小原 悠, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　67回　157-157　2008/09

    Publisher: (公社)日本矯正歯科学会

  145. IL-12の矯正学的歯の移動に及ぼす抑制作用のメカニズムの解析

    吉松 昌子, 北浦 英樹, 藤村 裕治, 小原 悠, 江口 俊子, 森田 幸子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　67回　167-167　2008/09

    Publisher: (公社)日本矯正歯科学会

  146. リコンビナントc-fmsによるM-CSFの作用抑制での矯正学的歯の移動の制御

    北浦 英樹, 藤村 裕治, 吉松 昌子, 小原 悠, 江口 俊子, 森田 幸子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　67回　262-262　2008/09

    Publisher: (公社)日本矯正歯科学会

  147. 歯の移動におけるIFN-γの発現・影響と破骨細胞形成に対する影響

    小原 悠, 北浦 英樹, 藤村 裕治, 吉松 昌子, 江口 俊子, 森田 幸子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　67回　263-263　2008/09

    Publisher: (公社)日本矯正歯科学会

  148. 破骨細胞形成関連細胞のTNF-αによる破骨細胞形成時のかかわりあいについてのin vivoでの検討

    北浦 英樹

    松本歯学　34　(2)　188-189　2008/08

    Publisher: 松本歯科大学学会

    ISSN： 0385-1613

    eISSN： 2188-7233

  149. Coll-Bcl-2トランスジェニックマウスにおける歯牙組織の解析

    江口 俊子, 宮崎 敏博, 森石 武史, 金谷 直子, 北浦 英樹, 吉田 教明, 小守 壽文

    解剖学雑誌　83　(1)　32-32　2008/03

    Publisher: (一社)日本解剖学会

    ISSN： 0022-7722

  150. Col1-Bcl-2トランスジェニックマウスにおける歯牙組織の解析

    江口俊子, 江口俊子, 宮崎敏博, 森石武史, 金谷直子, 北浦英樹, 吉田教明, 小守壽文

    解剖学雑誌　83　(1)　2008

    ISSN： 0022-7722

  151. A case of Maxillary protrusion and severe crowding treated with upper first premolar and upper/lower first molar extraction

    Yuji FUJIMURA, Hideki KITAURA, Masako YOSHIMATSU, Toshiko EGUCHI, Haruka KOHARA, Noriaki YOSHIDA

    Journal of Kyushu Orthodontic Society　4　(1)　65-72　2008

  152. FOCUS Bisphosphonate 歯の移動の抑制因子 歯の移動とビスフォスフォネート

    北浦 英樹, 古賀 正忠, 藤村 裕治, 吉田 教明

    The Quintessence　26　(11)　185-189　2007/11

    Publisher: クインテッセンス出版(株)

    ISSN： 0286-407X

  153. TNF-αによる破骨細胞形成のin vivoでの解析

    北浦英樹

    The Bone　21　(6)　751-754　2007/11

    Publisher: (株)メディカルレビュー社

    ISSN： 0914-7047

  154. 矯正歯科領域における金属アレルギー

    北浦英樹

    Journal of Orthodontic Practice　23　(11)　67-82　2007/11

    Publisher: 東京臨床出版(株)

    ISSN： 0912-1633

  155. 金属アレルギー患者用矯正ワイヤーの開発

    北浦 英樹, 中尾 紀子, 藤田 剛史, 白石 孝信, 古賀 義之, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　66回　158-158　2007/09

    Publisher: (公社)日本矯正歯科学会

  156. M-CSF receptor c-fms antibody inhibits mechanical stress-induced root resorption

    H. Kitaura, Y. Fujimura, M. Yoshimatsu, T. Eguchi, H. Kohara, N. Yoshida

    JOURNAL OF BONE AND MINERAL RESEARCH　22　S154-S154　2007/09

    ISSN： 0884-0431

  157. 矯正学的歯の移動におけるIL-12の効果

    吉松 昌子, 北浦 英樹, 藤村 裕治, 小原 悠, 江口 俊子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　66回　140-140　2007/09

    Publisher: (公社)日本矯正歯科学会

  158. ビスフォスフォネートによる歯科矯正学的な歯牙移動時の歯根吸収の抑制について

    藤村 裕治, 北浦 英樹, 吉松 昌子, 江口 俊子, 小原 悠, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　66回　141-141　2007/09

    Publisher: (公社)日本矯正歯科学会

  159. 抗c-fms抗体による矯正学的歯牙移動時の歯根吸収の抑制について

    江口 俊子, 北浦 英樹, 藤村 裕治, 吉松 昌子, 小原 悠, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　66回　141-141　2007/09

    Publisher: (公社)日本矯正歯科学会

  160. IFN-γのTNF-αによる破骨細胞形成における抑制作用について

    小原 悠, 北浦 英樹, 藤村 裕治, 吉松 昌子, 江口 俊子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　66回　142-142　2007/09

    Publisher: (公社)日本矯正歯科学会

  161. T細胞のTNF-αによる破骨細胞形成でのin vivoでのかかわりあいについての検討

    北浦 英樹, 吉田 教明

    Journal of Oral Biosciences　49　(Suppl.)　153-153　2007/08

    Publisher: (一社)歯科基礎医学会

    ISSN： 1349-0079

    eISSN： 1880-3865

  162. Inhibitory factor of orthodontic tooth movement - Orthodontic tooth movement and bisphosphonate

    Hideki Kitaura, Masatada Koga, Yuji Fujimura, Noriaki Yoshida

    The Quintessence　26　(11)　185-189　2007

  163. The results of examination of dentition, occlusion and temporomandibular disorders in junior high school dental health program with the changes of the times.

    Nakao N, Kitaura H, Koga Y, Yoshida N

    J Kyushu Orthod Soc　3　(1)　1-8　2007

  164. 歯の移動の抑制因子 歯の移動とビスフォスフォネート

    北浦英樹, 古賀正忠, 藤村裕治, 吉田教明

    The Quintessence　26　(11)　2325-2329　2007

  165. 開咬を伴う上下顎前突叢生抜歯症例

    吉松昌子, 北浦英樹

    LAS Society news letter　85　9-15　2007

  166. 上下顎前突叢生抜歯症例

    藤村裕治, 北浦英樹

    LAS Society news letter　85　9-15　2007

  167. M-CSF抑制による矯正学的歯の移動の制御の可能性について

    北浦 英樹, 吉松 昌子, 江口 俊子, 吉田 教明

    九州矯正歯科学会雑誌　2　(1)　42-42　2006/12

    Publisher: 九州矯正歯科学会

    ISSN： 1880-9596

  168. MBTシステム, そしてSmart Clipセルフライゲーションシステム

    北浦英樹

    Journal of Orthodontic Practice　22　(11)　11-24　2006/11

    Publisher: 東京臨床出版(株)

    ISSN： 0912-1633

  169. An antibody of the M-CSF receptor c-fms inhibits mechanical stress-induced osteoclastogenesis in vivo.

    H. Kitaura, M. Yoshimatsu, Y. Fujimura, T. Eguchi, N. Yoshida

    JOURNAL OF BONE AND MINERAL RESEARCH　21　S261-S261　2006/09

    ISSN： 0884-0431

  170. 長崎大学歯科矯正学におけるPBLへの取り組み

    飯島 静子, 吉田 教明, 北浦 英樹, 吉松 昌子

    日本矯正歯科学会大会プログラム・抄録集　65回　238-238　2006/09

    Publisher: (公社)日本矯正歯科学会

  171. The results of examination of dentition, occlusion and temporomandibular joint in school dental health program by orthodontic specialist.

    Nakao N, Kitaura H, Koga Y, Yoshida N

    J Kyushu Orthod Soc　2　(1)　15-24　2006

  172. 上顎前突叢生抜歯症例

    北浦英樹

    LAS Society news letter　83　5-11　2006

  173. 下顎前突開咬抜歯症例

    北浦英樹

    LAS Society news letter　82　2-7　2006

  174. IL-12による破骨細胞様細胞形成抑制の作用機序について

    永田 礼子, 北浦 英樹, 藤村 裕治, 中山 浩次, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　62回　206-206　2003/10

    Publisher: (公社)日本矯正歯科学会

  175. 高速螺旋CTを用いた三次元セファロメトリーでの角度計測の誤差について

    富樫 久美子, 北浦 英樹, 吉田 教明, 北森 秀希, 中村 卓

    日本矯正歯科学会大会プログラム・抄録集　62回　232-232　2003/10

    Publisher: (公社)日本矯正歯科学会

  176. IL-12による破骨細胞形成抑制作用のメカニズムの解明 破骨細胞形成誘導因子(RANKLとTNF-α)による違い

    永田 礼子, 北浦 英樹, 藤村 裕治, 佛坂 斉祉, 畳屋 睦人, 吉田 教明

    西日本歯科矯正学会雑誌　48　(1)　70-70　2003/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  177. Photocatalytic bactericidal effect on oral anaerobic bacteria.

    N. Suketa, T. Sawase, H. Kitaura, M. Naito, K. Baba, K. Nakayama, M. Atsuta

    JOURNAL OF DENTAL RESEARCH　82　B389-B389　2003/06

    ISSN： 0022-0345

  178. Interleukin-18 induces apoptosis of bone marrow cells in tumor necrosis factor-alpha mediated osteoclastogenesis

    M Tatamiya, H Kitaura, N Nagata, N Yoshida, K Nakayama

    BONE　32　(5)　S157-S157　2003/05

    ISSN： 8756-3282

  179. Interleukin-12 inhibits RANKL-induced osteoclast formation in mouse bone marrow cells by T cell and IFN-gamma-independent mechanism

    N Nagata, H Kitaura, M Tatamiya, N Yoshida, K Nakayama

    BONE　32　(5)　S155-S155　2003/05

    ISSN： 8756-3282

  180. Evaluation of sterilization and degradation of orthodontic elastics with strongly acid electrolytic water

    N Nakao, H Kitaura, N Yosida

    J Jpn Soc Oral Funct Water　4　(1)　3-7　2003

  181. I級叢生非抜歯症例

    北浦英樹, 永田礼子

    LAS Society news letter　72　2-10　2003

  182. 上顎前突抜歯症例（叢生を伴う）

    北浦英樹

    LAS Society news letter　71　12-20　2003

  183. III級開咬非抜歯症例

    北浦英樹

    LAS Society news letter　71　3-11　2003

  184. マウス骨髄細胞におけるRANKL及びTNF-alphaによる破骨細胞形成へのIL-18の効果

    畳屋 睦人, 北浦 英樹, 永田 礼子, 中尾 紀子, 藤村 裕治, 佛坂 斉祉, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　61回　178-178　2002/10

    Publisher: (公社)日本矯正歯科学会

  185. エラスティックに対する強酸性電解水滅菌の検討

    中尾 紀子, 北浦 英樹, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　61回　246-246　2002/10

    Publisher: (公社)日本矯正歯科学会

  186. Porphyromonas gingivalis菌体表面タンパク(HGP15)の破骨細胞様細胞形成への影響について

    藤村 裕治, 北浦 英樹, 永田 礼子, 坂井 詠子, 鎌口 有秀, 吉田 教明, 中山 浩次

    歯科基礎医学会雑誌　44　(5)　429-429　2002/09/20

    Publisher: 歯科基礎医学会

    ISSN： 0385-0137

  187. IL-12の破骨細胞形成間接的抑制作用 〜T細胞およびIFN-γ非依存性作用機序について〜

    永田 礼子, 北浦 英樹, 藤村 裕治, 吉田 教明, 中山 浩次

    歯科基礎医学会雑誌　44　(5)　431-431　2002/09/20

    Publisher: 歯科基礎医学会

    ISSN： 0385-0137

  188. RANKLおよびTNF-αによる破骨細胞形成誘導へのIL-18の影響について

    畳屋 睦人, 北浦 英樹, 永田 礼子, 藤村 裕治, 吉田 教明, 中山 浩次

    歯科基礎医学会雑誌　44　(5)　431-431　2002/09/20

    Publisher: 歯科基礎医学会

    ISSN： 0385-0137

  189. Interleukin-12 induces apoptosis of bone marrow cells in tumor necrosis factor-alpha mediated osteoclastogenesis

    H Kitaura, N Nagata, M Tatamiya, N Yoshida, K Nakayama

    JOURNAL OF BONE AND MINERAL RESEARCH　17　S343-S343　2002/09

    ISSN： 0884-0431

  190. IL-4による破骨細胞様細胞形成抑制作用について

    藤村 裕治, 北浦 英樹, 永田 礼子, 吉田 教明

    西日本歯科矯正学会雑誌　47　(1)　58-58　2002/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  191. 破骨細胞培養におけるTNF-α及びIL-12の相互作用によるアポトーシスとNOとの関連性について

    永田 礼子, 北浦 英樹, 藤村 裕治, 吉田 教明

    西日本歯科矯正学会雑誌　47　(1)　58-59　2002/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  192. 外科手術後に金属アレルギーが疑われた症例について

    北浦 英樹, 中尾 紀子, 吉田 憲弘, 永田 礼子, 藤村 裕治, 吉田 教明

    西日本歯科矯正学会雑誌　47　(1)　67-67　2002/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  193. 矯正領域の金属アレルギーについて

    北浦英樹

    アレキサンダー研究会会誌　17　50-55　2002

  194. 上顎前突抜歯症例

    北浦英樹

    LAS Society news letter　70　2-11　2002

  195. 多数埋伏過状歯を伴うI級非抜歯症例

    北浦英樹

    LAS Society news letter　67　3-11　2002

  196. TNF-α及びIL-12の相互作用による骨髄細胞のアポトーシス誘導について

    北浦 英樹, 永田 礼子, 藤村 裕治, 佛坂 斉祉, 中山 浩次, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　60回　197-197　2001/10

    Publisher: (公社)日本矯正歯科学会

  197. 骨髄細胞培養におけるIL-12の破骨細胞様細胞形成抑制作用

    永田 礼子, 北浦 英樹, 藤村 裕治, 中山 浩次, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　60回　198-198　2001/10

    Publisher: (公社)日本矯正歯科学会

  198. 強電解酸性水の影響による矯正装置からのニッケル溶出について

    藤村 裕治, 北浦 英樹, 永田 礼子, 中尾 紀子, 吉田 教明

    日本矯正歯科学会大会プログラム・抄録集　60回　253-253　2001/10

    Publisher: (公社)日本矯正歯科学会

  199. 矯正歯科領域での金属アレルギーについて

    北浦 英樹

    日本矯正歯科学会大会プログラム・抄録集　60回　122-122　2001/10

    Publisher: (公社)日本矯正歯科学会

  200. The effects of strongly acid electrolytic water for the orthodontic wires -Ni release by strongly acid electrolytic water-

    H Kitaura, N Adachi, N Nagata, K Kobayashi

    J Jpn Soc Oral Funct Water　2　(1)　11-17　2001

  201. 金属アレルギーの実験モデルの作製と各種矯正用ワイヤーとの反応について

    北浦 英樹, 中尾 紀子, 藤村 裕治, 小林 和英

    日本矯正歯科学会大会プログラム・抄録集　59回　189-189　2000/10

    Publisher: (公社)日本矯正歯科学会

  202. 歯科矯正用ワイヤーからのニッケルの溶出について

    中尾 紀子[安達], 北浦 英樹, 小林 和英

    日本矯正歯科学会大会プログラム・抄録集　59回　191-191　2000/10

    Publisher: (公社)日本矯正歯科学会

  203. 矯正用ワイヤーに対する強電解酸性水の影響について 強酸によるニッケル溶出との比較

    永田 礼子, 北浦 英樹, 中尾 紀子, 小林 和英

    日本矯正歯科学会大会プログラム・抄録集　59回　241-241　2000/10

    Publisher: (公社)日本矯正歯科学会

  204. 高速螺旋CTを用いた三次元セファロメトリー撮影時の頭位の違いによる誤差の検討

    富樫 久美子, 北浦 英樹, 小林 和英, 中村 卓

    日本矯正歯科学会大会プログラム・抄録集　59回　214-214　2000/10

    Publisher: (公社)日本矯正歯科学会

  205. スライディングメカニクスで治療した下顎両側側切歯の先天性欠如を伴う上顎前突症例

    北浦 英樹

    西日本歯科矯正学会雑誌　45　(1)　109-109　2000/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  206. 金属アレルギーの実験モデルの作製と矯正歯科領域への応用について

    北浦 英樹, 安達 紀子, 池田 美和, 井口 修一郎, 小林 和英

    西日本歯科矯正学会雑誌　45　(1)　87-87　2000/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  207. 矯正歯科領域における金属アレルギーに関する研究 矯正用ワイヤーからのニッケルの溶出について

    安達 紀子, 北浦 英樹, 小林 和英

    西日本歯科矯正学会雑誌　45　(1)　77-77　2000/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  208. 高速螺旋CTによる三次元セファロメトリーと撮影時の頭位の検討

    富樫 久美子, 北浦 英樹, 渡辺 悦子, 小林 和英

    西日本歯科矯正学会雑誌　45　(1)　77-77　2000/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  209. アメリカと日本における不正咬合の社会心理的影響の比較検討 Oral Health Impact Profile(OHIP)を応用して

    渡辺 悦子, 吉田 教明, 北浦 英樹, 古賀 義之, 井口 修一郎, 安達 紀子, 中川 麻紀, 小林 和英

    西日本歯科矯正学会雑誌　45　(1)　81-81　2000/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  210. 抗酸菌の重感染によるHIV-1複製亢進とサイトカインについて

    北浦 英樹, 大原 直也, 山田 毅

    日本細菌学雑誌　55　(2)　211-211　2000/04

    Publisher: 日本細菌学会

    ISSN： 0021-4930

    eISSN： 1882-4110

  211. 矯正用材料に対する強電解酸性水の影響について 各種酸によるニッケル溶出との比較

    北浦 英樹, 安達 紀子, 小林 和英

    日本口腔機能水学会誌　1　(1)　70-71　2000/03

    Publisher: 日本口腔機能水学会

  212. III級非抜歯症例

    北浦英樹

    LAS Society news letter　61　1-12　2000

  213. 細胞内寄生菌の重感染によるHIV-1複製亢進とサイトカインについて

    北浦 英樹, 山田 毅

    歯科基礎医学会雑誌　41　(5)　481-481　1999/08/20

    Publisher: 歯科基礎医学会

    ISSN： 0385-0137

  214. 歯根水平破折歯の再植後に治療したアングルII級叢生症例

    北浦 英樹

    西日本歯科矯正学会雑誌　44　(1)　145-145　1999/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  215. 分泌型リボゾーム蛋白質L7/L12の遅延型アレルギー反応について

    北浦 英樹, 大原 直也, 西山 毅, 木之本 雅通, 山田 毅

    日本細菌学雑誌　54　(1)　318-318　1999/02

    Publisher: 日本細菌学会

    ISSN： 0021-4930

    eISSN： 1882-4110

  216. 高速螺旋CTによる三次元セファロメトリ

    米津 康一, 北浦 英樹, 北森 秀希, 中村 卓

    歯科放射線　38　(増刊)　75-75　1998/09

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  217. 強酸性電解水滅菌による矯正用切断器具の切断性への影響について

    北浦 英樹, 古賀 義之, 安達 紀子, 池田 美和, 井口 修一郎, 吉田 憲弘, 畳屋 睦人, 小林 和英

    西日本歯科矯正学会雑誌　43　(1)　57-57　1998/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  218. 各種抗酸菌のα抗原に対する特異的なB-cellエピトープについて

    北浦 英樹

    日本細菌学雑誌　53　(1)　158-158　1998/02

    Publisher: 日本細菌学会

    ISSN： 0021-4930

    eISSN： 1882-4110

  219. 機能的顎矯正装置の終日使用により悪習癖が改善した上顎前突症例

    北浦 英樹

    西日本歯科矯正学会雑誌　42　(1)　72-73　1997/08

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  220. 抗酸菌のHIV-1-LTR活性作用について

    北浦 英樹

    日本細菌学雑誌　52　(1)　327-327　1997/01

    Publisher: 日本細菌学会

    ISSN： 0021-4930

    eISSN： 1882-4110

  221. Mycobacterium intracellulareのα抗原に対する特異的なB-cellエピトープについて

    北浦 英樹

    日本細菌学雑誌　51　(1)　314-314　1996/01

    Publisher: 日本細菌学会

    ISSN： 0021-4930

    eISSN： 1882-4110

  222. 歯科医療従事者のHIV感染予防に関する意識調査について

    北浦 英樹

    西日本歯科矯正学会雑誌　40　(2)　107-108　1995/12

    Publisher: 西日本歯科矯正学会

    ISSN： 0911-2839

  223. PCR法による抗酸菌検出のための内部コントロールの作製について

    北浦 英樹

    日本細菌学雑誌　50　(1)　228-228　1995/01

    Publisher: 日本細菌学会

    ISSN： 0021-4930

    eISSN： 1882-4110

  224. 結核発病における菌側の因子；抗酸菌の抗原の研究の意味

    山田毅, 大原直也, 松本壮吉, 松尾長光, 北浦英樹, 高野美貴子, 雪竹英治, 和田直子, 西山毅, 内藤真理子, 木ノ本雅道, 木村誠

    結核　70　639-644　1995

  225. Mycobacterium intracellulareのα抗原遺伝子のクローニングおよび発現について

    北浦 英樹

    日本細菌学雑誌　49　(1)　287-287　1994/01

    Publisher: 日本細菌学会

    ISSN： 0021-4930

    eISSN： 1882-4110

  226. Mycobacteria属の迅速検出法及びMycobacterium intracellulareの迅速同定法

    北浦 英樹

    日本細菌学雑誌　48　(1)　300-300　1993/01

    Publisher: 日本細菌学会

    ISSN： 0021-4930

    eISSN： 1882-4110

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Books and Other Publications 6

  1. 歯科矯正学第６版

    北浦英樹

    医歯薬出版　2019/04

  2. 歯科矯正用アンカースクリューを用いた矯正歯科治療アトラス 上下顎前歯部叢生症例

    北浦英樹

    2019/01

  3. 歯科矯正用アンカースクリューを用いた矯正歯科治療アトラス 上下顎前突症例

    北浦英樹

    2019/01

  4. 3.11 東日本大震災 東北矯正歯科学会の記憶

    北浦英樹

    2017/03

  5. 骨ペディア 骨疾患・骨代謝キーワード辞典

    北浦英樹

    2015/01

  6. 歯根吸収の生物学的メカニズムと制御について 臨床家のための矯正YEARSBOOK2014 原点回帰 -矯正の未来を見据えて-

    北浦英樹

    2014/01

Show all Show first 5

Research Projects 24

  1. 骨細胞アポトーシスに着目した矯正学的歯の移動に伴う機械刺激応答性骨吸収機序の解明

    溝口 到, 北浦英樹, 福永智広, 千葉美麗, 吉田倫子, 伊藤 新

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04 - 2026/03

  2. Effects of defective glucose metabolism in osteocytes on osteoclastogenesis and orthodontic tooth movement

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04 - 2025/03

  3. TNF-αによる骨細胞の遺伝子発現の網羅的解析

    小川 紗衣香, 溝口 到, 北浦 英樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

    More details Close

    近年、炎症性のサイトカインであるTNF-αで破骨細胞が誘導されることがわかってきた。関節リウマチや歯周病などの感染による病的骨吸収は、TNF-αが主に関与しているものだと考えられている。また、申請者らの研究で矯正学的歯の移動においてもTNF-αが発現し破骨細胞および骨形成に関与していることがわかっている。特にTNF-αが骨細胞を含む間質系細胞に作用することが重要だと見出している。一方、生理的な骨吸収に関しては骨細胞がRANKLを発現し、破骨細胞形成を誘導していることが新しくわかった。また、我々の研究でTNF-αが骨細胞に作用し、RANKLの発現を増強し、破骨細胞形成を誘導することを見出している。本研究では、TNF-αが骨細胞に作用することでどのような因子が増加し、あるいは減少しているか網羅的に解析することで、さらにTNF-αが骨細胞にどのような影響をあたえているのかそのメカニズムを解明することを目的とする。DMP1プロモーターの下流にGFPの異型のTopazを骨細胞が発現し、蛍光する5-6日齢のDMP1-Topaz（C57BL/6-Tg(Dmp1-Topaz)1lkal/J）マウスの頭蓋骨にコラゲナーゼおよびEDTAを用いて段階的な酵素処理を行い、得られたFraction2-5を回収した。10%FBSを含むαMEM培地で24時間培養後、付着細胞のみを回収し、cell sorter （FACS AriaⅢ）により初代骨細胞としてTopaz陽性骨細胞の単離を行った。この骨細胞にTNF-αを加え培養したものおよび加えずに培養したものからtotalRNAを回収した。それぞれTotalRNAをRNAシークエンス行った。結果、TNF-αで刺激したものでは破骨細胞形成関連遺伝子等の発現が増加した。

  4. Analysis of osteoclastogenesis and orthodontic tooth movement in an experimental hypertensive mouse model

    Kitaura Hideki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

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    We succussed to establish hypertensive mice by feeding LNAME. When hypertensive mice were injected with LPS, osteoclast formation and bone resorption were increased in hypertensive mice compared to normal mice. In addition, TNF-α in the serum of hypertensive mice was increased. Furthermore, the expression of AT1R was increased, and the expression of ATGR1 was found to increase when TNF-α acted on osteoblasts in vitro. Furthermore, femurs from hypertensive mice showed decreased bone mass and osteoporosis-like findings. These findings indicate that hypertension increases TNF-α and AGTR1 expression in osteoblasts, which in turn increases RANKL expression and osteoclastogenesis.

  5. Role of Runx2 in bone remodeling induced by mechanical stress in the animal model of Cleidocranial dysplasia

    FUKUNAGA Tomohiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    Cleidocranial dysplasia (CCD) is caused by mutations of RUNX2, and orthodontic treatment for CCD patients is difficult because of impaired tooth movement. We examined the amount of experimental tooth movement in Runx2+/- mice, the animal model of CCD, and continuous stretch was conducted to bone marrow stromal cells (BMSCs). Compared to wild-type the Runx2+/- mice exhibited delayed experimental tooth movement, and osteoid formation were impaired on the tension side of tooth movement. Runx2+/- BMSCs decreased stretch-induced proliferation. Furthermore, mTORC2 is regulated by Runx2 to phosphorylate Akt to regulate cell proliferation and differentiation. Runx2+/- mice exhibited delayed and suppressed expression of mTOR and Rictor in osteoblasts on the tension side of tooth movement. Runx2+/- BMSCs inhibited stretch-induced PI3K dependent mTORC2/Akt activity to promote BMSCs proliferation. mTORC2 regulated stretch-elevated Runx2 and ALP mRNA expression in BMSCs in osteogenic medium.

  6. Effect of neuropeptide oxytocin on osteoclast and orthodontic tooth movement

    Kohara Haruka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Nagasaki University

    2018/04/01 - 2021/03/31

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    The effect of oxytocin on osteoclastogenesis was examined by adding oxytocin to mouse osteoclast progenitor cells. The number of osteoclasts was not increased significantly by oxytocin. Oxytocin was then applied to the mice whose maxillary first molar was applied with an orthodontic force, but no effect was observed. In addition, mRNA for osteoclast differentiation markers was quantified in osteoclasts when orthodontic force was applied. The results showed that no marker was significantly different by oxytocin administration. These results suggest that oxytocin may not affect osteoclast differentiation induced by orthodontic force. However, we believe that it may have an effect in pathological settings such as periodontal disease and osteoporosis, and we plan to further study osteoclastogenesis under such conditions.

  7. the analysis of relationship between fatty acids and bone metabolism in free fatty acid receptor GPR120 knockout mice.

    Kimura Keisuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    In vitro, RANKL and TNF-α-induced osteoclast formation of wild-type mice was suppressed by DHA in vitro, but not inhibited that of GPR120 knockout mice. LPS was administered to supracalvariae for 5 days and osteoclast formation was examined. Osteoclast formation was suppressed in wild-type mice when DHA was co-administered, but not observed in GPR120 knockout mice. Therefore, it was clarified that LPS-induced osteoclast formation in vivo was suppressed by GPR120 stimulation. In addition, DHA was administered to a model of orthodontic tooth movement mouse model in wild-type mice. DHA had suppressed tooth movement. Furthermore, this inhibitory effect could not be confirmed in GPR120 knockout mice. These results suggested that orthodontic tooth movement is suppressed by DHA via GPR120 signaling.

  8. Effects of Blimp-1 for chemotherapy induced oral mucositis

    YOSHIMATSU Masako

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Nagasaki University

    2018/04/01 - 2021/03/31

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    It has been reported that suppression of Blimp-1 caused inhibition of TNF-alpha induced osteoclastogenesis. Appearance of oral mucositis is related with TNF-alpha. Therefore, we predicted that Blimp-1, induced by immune response, might be related with oral mucositis. For that, model of oral mucositis in mice was used with intraperitoneally injection of 5-FU. After expression of oral mucositis, localizaion of Blimp-1 was histologically evaluated using immunostaining. The expression of Blimp-1 was not recognized in the region of oral mucositis. The results suggest that Blimp-1 unlikely express in oral mucositis induced by chemotherapy.

  9. Evaluation of functions of novel adapter molecules on bone metabolism and orthodontic tooth movement

    Kitaura Hideki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    It has been reported that ITAM is essential for osteoclast differentiation, since the double-defective mouse of adapter molecules FcRγ and DAP12 with ITAM shows a differentiation failure of osteoclasts. A STAM including ITAM motif has been identified as a functional molecule involved in cell proliferation signal transduction. Osteoclastogenesis was carried out by overexpressing STAM1 molecules in osteoclast precursor cells prepared from wild-type mice using a retrovirus. Overexpression of STAM1 promoted osteoclastogenesis. On the other hand, osteoclast formation was suppressed when knockdown of STAM1 was performed using shRNA to osteoclast precursor cells. The results suggested that STAM play an important role in osteoclast formation.

  10. Functional analysis of Runx2 in bone resorption in the animal model of Cleidocranial dysplasia

    FUKUNAGA Tomohiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    Cleidocranial dysplasia (CCD) is caused by mutations of RUNX2. However, the mechanism of orthodontic tooth movement in CCD patients has not been clarified. We examined the amount of experimental tooth movement in hetero mice deficient in RUNX2 gene (hetero KO mice), the animal model of CCD. Compared to wild-type mice, the hetero KO mice exhibited delayed experimental tooth movement, and osteoid formation. Moreover, we applied continuous mechanical tensile force to bone marrow stromal cells (BMSCs) as an in vitro model of the tension side of tooth movement. Runx2 hetero deficiency delayed tensile force-induced increase of DNA content in BMSCs, and also delayed and reduced tensile force-induced ALP activity, calcium content, and OSC mRNA expression of BMSCs in osteogenic medium compared to wild-type BMSCs.

  11. Role of bone metabolism caused by mechanical stress in SHIP KO mice

    YOSHIMATSU Masako, KITAURA Hideki, HOTOKEZAKA Hitoshi, FUJIMURA Yuji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Nagasaki University

    2012/04/01 - 2016/03/31

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    SHIP (SH2-containing inositol-5'-phosphatase) plays an important role for signal transduction of B cell receptor in immunoreaction. In bone metabolism, closely associated with immunology, SHIP also has been researched in recent years. We showed that SHIP might negatively regulate TNF-α mediated osteoclastogenesis in vitro. We also investigated the effect of SHIP caused by methanical stress using an orthodontic tooth movement model in vivo. The amount of tooth movement in SHIP knockout mice wasn’t significantly increased compared with control mice.

  12. Effect of osteocyte in TNF-a-induced osteoclast formation

    KITAURA Hideki, YAMAMOTO Teruko, TAKESITA Nobuo, SEIRYU Masahiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    We purified osteocytes from mouse carvariae by using collagenase and EDTA after removing soft tissues. We analyzed the purification of osteocyte by quantified expression level of DMP-1 with real-time PCR. We found that fraction 5 maximally included osteocytes. We cultured the cells in fraction 5 as osteocyte with TNF-α in α-MEM. Total RNA was isolated from adherent cells. We quantified expression level of osteoclast related genes. We found that expression of RANKL was increased in osteocytes cultured with TNF-α.

  13. Integrated study on mechanism of development and disorder of masticatory and swallowing function and visualization of neural circuits

    YOSHIDA Noriaki, KOGA Yoshiyuki, KITAURA Hideki, TANAKA Motohiro, UTSUMI Kai, INOUE Tomio, ENOUE Makoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Nagasaki University

    2009 - 2011

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    A process of development of masticatory and swallowing function was elucidated. As a result, it was suggested that the critical period of development of those functions was beyond 6 weeks of age in mice. Regarding the mechanism of disorder of masticatory and swallowing function, the formation of an abnormal central pattern generator is unlikely to occur. Such a disturbance may be produced at the site inferior to the central pattern generator. The obtained results indicated that neural circuits controlling jaw and tongue movements have a mutual interaction.

  14. Analysis of SHIP related to osteoclastogenesis

    YOSHIMATSU Masako, KITAURA Hideki, YOSHIDA Noriaki, FUJIMURA Yuji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Nagasaki University

    2009 - 2011

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    SH2-containing inositol-5'-phosphatase(SHIP), which is related to immunoreaction, has been reported to negatively regulate the proliferation of osteoclast precursors induced by macrophage colony-stimulating factor(M-CSF) and ligand for receptor activator of nuclear factor kappa B(RANKL). In this study, we investigated the effects of SHIP on TNF-α-induced osteoclastogenesis. Bone marrow cells from SHIP+/+ and SHIP-/-mice were cultured with M-CSF and TNF-α. The number of TRAP-positive cells was significantly increased in SHIP-/-cells compared with SHIP+/+ cells. These results suggest that SHIP may negatively regulate the proliferation of osteoclast precursors.

  15. Analysis of tooth movement mechanism in TNF receptors deficient chimera mouse

    KITAURA Hideki, YOSHIMATSU Masako, MASUYAMA Ritsuko, FUJIMURA Yuji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2009 - 2011

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    We generated chimeric mice using wild type (WT)or TNF receptor deficient (KO)marrow, immunodepleted of T-cells and stromal cells. The samples were reciprocally transplanted into WT or KO mice following lethal irradiation to eliminate native marrow. We established an orthodontic tooth movement model in mice by using a Ni-Ti closed coil spring. We found that orthodontic tooth movement was occurred in chimeric mice.

  16. 咀嚼と脳発達における歯と歯根膜の役割―無歯顎モデルマウスを用いた統合的研究―

    吉田 教明, 芝崎 龍典, 田中 基大, 古賀 義之, 北浦 英樹, ゼレド ジョージ, 岡安 一郎, 山田 好秋

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 挑戦的萌芽研究

    Category: 挑戦的萌芽研究

    Institution: 長崎大学

    2007 - 2009

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    歯および歯根膜の存在が咀嚼機能・脳機能の発達にどのような役割を果たすかを解明するため、先天的に歯が欠損、すなわち歯根膜機械受容器からの感覚入力のない無歯顎モデル(op/opマウス)の咀嚼機能の解析を行い、機能の発達の程度について、健常マウスと比較した。 その結果、矢状面における咀嚼サイクルは、健常マウスでは閉口相、前方移動相、開口相の3相に分けられたが、op/opマウスでは、明らかな前方移動相が認められず、閉口相と開口相の2相に分けられ、咀嚼パターンの獲得に有意な差がみられた。食品の硬度が低下するに従って、前方移動相の周期時間が短縮するという傾向がみられ、柔らかい食品の咀嚼に適したパターンが習得されたものと考えられる。周期時間について、健常マウスと比較してop/opマウスの全周期時間と開口相時間は有意に長かった。 筋活動に関して、活動量は咬筋、顎二腹筋ともに両群に有意差がみられなかった。活動時間は、咬筋では両群に有意差がみられなかったものの、顎二腹筋の活動時間はop/opマウスの方が健常マウスよりも有意に長かった。以上のことから、op/opマウスは、開口相において、舌を積極的に使用して、食物を口蓋に押しつけ、すりつぶすような咀嚼様式を獲得したことが示唆された。 歯が存在しないことが咀嚼運動に及ぼす影響には、歯根膜機械受容器からの入力が閉口筋活動の末梢性調節あるいはフィードバックに働かないことの他に、歯がないための咬合ガイドの欠損による咀嚼運動経路の安定性の低下が考えられるものの、歯および歯根膜機械受容器の存在が顎口腔機能の健全な発達に重要な役割を果たしていることが示唆された。 また、先天的に歯根膜機械受容器が欠損していたとしても、筋紡錘や、顎顔面領域の他の感覚受容器が歯根膜機械受容器の役割をある程度補うことも考えられた。

  17. Elucidation of the mechanism of skeletal development using Runx2 and Cbfb conditional knockout mice

    KOMORI Toshihisa, IZUMI Shinichi, MIYAZAKI Toshihiro, YOSHIDA Carolina Andrea, MORIISHI Takeshi, NAKAYAMA Koji, KITAURA Hideki, ITO Masako, FUKUYAMA Ryo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Nagasaki University

    2007 - 2008

  18. Investigation into mechanism of development of stomatognathic function using knock-out mice accompanied by oral motor disorders

    YOSHIDA Noriaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Nagasaki University

    2006 - 2008

  19. An anti-c-Fms Antibody Inhibits Orthodontic Tooth Movement

    KITAURA Hideki, YOSHIMATSU Masako

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Nagasaki University

    2006 - 2007

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    Orthodontic force induces osteoclastogenesis in vivo. It has recently been reported that administration of an antibody against the macrophage-colony-stimulating factor(M-CSF)receptor c-Fms blocks osteoclastogenesis and bone erosion induced by tumor necrosis factor-α(TNF-α)administration. This study aimed to examine the effect of an anti-c-Fms antibody on mechanical loading-induced osteoclastogenesis and osteolysis in an orthodontic tooth movement model in mice. Using TNF receptor 1 and 2-deficient mice, we showed that orthodontic tooth movement was mediated by TNF-α. We injected anti-c-Fms antibody daily into a local site, for 12 days, during mechanical loading. The anti-c-Fms antibody significantly inhibited orthodontic tooth movement, markedly reduced the number of osteoclasts in vivo and inhibited TNF-α-induced osteoclastogenesis in vitro. These findings suggest that M-CSF plays an important role in mechanical loading-induced osteoclastogenesis and bone resorption during orthodontic tooth movement mediated by TNF-α.

  20. Development of mechanics of efficient tooth movement for reduction of orthodontic treatment period

    YOSHIDA Noriaki, KOGA Yoshiyuki, IWABE Tatsunori, ISHIMATSU Takakazu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Nagasaki University Graguate School of Biomedical Sciences

    2002 - 2005

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    Control of anterior teeth movement is essential to the success of an orthodontic treatment. In Sliding Mechanics, horizontal level of retraction force can be freely adjusted by soldering various lengths of power arms to an arch wire. Therefore, the force system for desired type of tooth movement can be simply applied. The purpose of this study was to determine what level of retraction force, namely, what length of power arm allow the anterior teeth to retract to a desired position. Human subject with upper right central incisor was chosen as target tooth. Initial tooth movement under sliding mechanics with various horizontal retraction forces were measured by Two-point Three-Dimensional Displacement Magnetic Sensor Device. The sensors detected and recorded initial displacement of target tooth in real time. The tooth's motion trajectories projected on the sagital plane was studied. It was suggested that the location of center of rotation of the target tooth varies according to the height level of retraction force application. Therefore, anterior tooth can be tipped crown-lingually or root-lingually in a pre-determined course by manipulating the location of center of rotation or rather the height level of retraction force application, i.e. the length of power arms itself. This would be of great help to orthodontists for establishing efficient treatment planning for patients.

  21. Effect of-mechanicalstress on osteoblast and osteoclast like cell

    NAKAO Noriko, TATAMIYA Mitsuhito

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Nagasaki University

    2001 - 2003

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    The mechanical stress, which were both the gravity and the electromagnetic field, stimulated the ALPase activity in a dose. dependent manner. The results suggested that the mechanical stress induced the differentiation of the human osteoblast-like cell. Furthermore, the pulse electromagnetic held load inhibited ALPase activity in the cell culture before the cell confluent. It. was clear that the pulse electromagnetic held load effected the human osteoblast-like cell in the proliferation the period. F6-1, 25(OH)2D3 and 1-25(OH)2D3 also effected the stimulation of the human osteoblast-like cell proliferation by the gravity and the electromagnetic field. In general, the increase of ALPase activity and the production of BGP, which was non-collagen substrate protein, were related each other. But, the different production of BMP in the gravity and in the pulse electromagnetic field was recognized in this study. However, the gravity, which was the centrifugal force, did not effect both the RANKL-and TNF-α-induced osteoclastogenesis. These results suggested that the mechanical was useful for bone formation because it induced the osteoblast-formation but not the osteoclastogenesis.

  22. IL-12の破骨細胞形成抑制に関するメカニズムの解明

    北浦 英樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 長崎大学

    2001 - 2002

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    骨の吸収には、骨芽細胞等から産生されたRANKLによって誘導された破骨細胞による生理的骨吸収と、TNF-αによって誘導された破骨細胞によって引き起こされる病的骨吸収があると考えられている。また、その制御には、様々なサイトカインの関与が考えられている。近年、破骨細胞誘導に免疫担当細胞の関与が多く報告されている。しかしながら、免疫において重要な働きをしているIL-12と骨代謝に関しての報告はほとんどない。そこで本報告では、TNF-αによる破骨細胞誘導へのIL-12の影響の検討を行った。5週齢ddYマウスの大腿骨および脛骨から骨髄細胞を採取し、全骨髄細胞を,M-CSFおよびTNF-α存在下で培養し同時にIL-12を0.001〜100ng/mlの濃度で作用させた。また、骨髄細胞から得られたM-CSF依存性のマクロファージ(破骨細胞前駆細胞)をM-CSFおよびTNF-α存在下でIL-12を作用させた。それぞれ、TRAP陽性細胞の数を測定した。全骨髄細胞をM-CSF存在下でTNF-α単独で作用させた場合、破骨細胞様細胞が形成されたが、同時にIL-12を作用させた場合、用量依存的に付着細胞の数が減少した。全細胞を回収し、DNAのフラグメンテーションを解析したところ、約180bpごとのラダーが認められた。また、この作用は、破骨細胞前駆細胞を用いた場合には、起こらなかった。これらのことから、TNF-αとIL-12を同時に全骨髄細胞に作用させるとアポトーシスを誘導する事がわかった。また、その作用は、破骨細胞前駆細胞への直接作用ではないことが示唆された。このアポトーシスを起こす原因は、骨髄細胞の非付着細胞にIL-12が作用して、FasLを発現させ、付着細胞にTNF-αが作用してFasを発現することにより、付着細胞にFas-FasLの相互作用によることがわかった。

  23. 金属アレルギー誘発の原因となる金属結合蛋白の同定と金属アレルギー実験モデルの確立

    北浦 英樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 奨励研究(A)

    Category: 奨励研究(A)

    Institution: 長崎大学

    1999 - 1999

  24. The development of monitoring system of root resorption during ortodontic treatment

    KOBAYASHI Kazuhide, YOSHIDA Noriaki, KITAURA Hideki, IGUCHI Syuichirou

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Nagasaki University

    1996 - 1998

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    Root resorption is one of the most common iatrogenic sequelae of orthodontic treatment. Recently, root contact with the labial or palatal cortical plate at root apex level during orthodontic tooth movement was reported to be related to root resorption, and dentofacial morphology was suggested to predispose certain persons to root contact with the corticaiplate. In this study, we constructed a best-fit straight line for the maxillary palatal cortical plate and set a line for the labial cortical plate from A point to Prosthion point in order to obtain measurements of proximity of root apices with the cortical plates of the maxillary alveolus. We investigated the correlation between apical root resorption and the measured variables. Our findings suggest that root approximation to the palatal cortical plate during orthodontic treatment could explain approximately 12% of the variance observed in the level of root resorption and the maxillary alveolar bone width about 2%. Tooth extrusion and crown lingualization also contributed to root resorption. We concluded that maxillary central incisor apical root resorption is influenced by root approximation to the palatal cortical plate during orthodontic treatment. Furthermore, there is an intimate relationship between tooth mobility and root resorption. There is a tendency that tooth with large mobility has a high level root resorption. However, we could not detect the protein of root or cytokine to induce bone resorption by ELISA- during orthodontic treatment. The evaluation of the risk of root resorption from lateral cephalometric head film during orthodontic treatment was useful for prevention of root resorption.

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