TOHOKU UNIVERSITY Researchers

Details of the Researcher

Home

日本語 English

Kenji Takeuchi

Section

Graduate School of Dentistry

Job title

Associate Professor

Degree

researchmap

https://researchmap.jp/k-takeuchi64

J-GLOBAL ID

201501016226500405

e-Rad No.

10712680

ORCID

https://orcid.org/0000-0001-8769-8955

Profile

Bibliography on PubMed: https://www.ncbi.nlm.nih.gov/myncbi/12gov99DnJC5S/bibliography/public/
Profile on Scopus: https://www.scopus.com/authid/detail.uri?authorId=55212946900

Research History 10

2022/11 - Present

Tohoku University
2021/11 - Present

Tohoku University
2021/11 - Present

Nagoya University
2024/10 - 2025/09

ハーバード大学　歯学部　研究員（若手リーダー海外派遣プログラム）
2023/04 - 2025/03

宮城県　保健福祉部　参与（歯科医療保健政策担当）
2019/03 - 2023/03

Kyushu University　Section of Preventive and Public Health Dentistry, Faculty of Dental Science　Collaborative Researcher
2021/11 - 2022/10

Tohoku University
2019/03 - 2021/11

Nagoya University　Department of Preventive Medicine　Associate Professor
2018/04 - 2019/02

Kyushu University　OBT Research Center, Faculty of Dental Science　Principal Investigator (Concurrent Post)
2013/04 - 2019/02

Kyushu University　Section of Preventive and Public Health Dentistry, Faculty of Dental Science　Assistant Professor

Show all Show first 5

Education 2

Tohoku University　Division of Dental Science　Department of International and Community Oral Health

2009/04 - 2013/03
Tohoku University　Faculty of Dentistry

2003/04 - 2009/03

Committee Memberships 28

日本疫学会　疫学専門家資格推進TF 委員

2025/01 - Present
厚生労働省・事務局（三菱総合研究所）　医歯薬連携による糖尿病重症化予防事業効果検証ワーキンググループ委員

2024/06 - Present
日本公衆衛生学会　査読委員

2024/04 - Present
日本疫学会　疫学専門家委員会認定試験WG 委員

2024/02 - Present
日本口腔衛生学会　代議員

2023/05 - Present
東北大学大学院歯学研究科　研究倫理委員会委員

2022/04 - Present
東北大学大学院歯学研究科　臨床疫学統計支援室室長

2021/11 - Present
日本老年歯科医学会　特任委員会（老健事業）委員

2021/07 - Present
日本疫学会　Journal of Epidemiology 編集委員

2021/01 - Present
ヘルスサイエンス・ヘルスケア　編集委員

2020/07 - Present
愛知県　歯科衛生士人材育成検討会議委員

2020/05 - Present
日本口腔衛生学会　新型コロナウイルス感染症（COVID-19）対策検討・作業部会委員

2020/05 - Present
日本疫学会　代議員

2019/06 - Present
日本口腔衛生学会　フッ化物応用委員会委員

2019/05 - Present
日本口腔衛生学会　学術委員会委員

2019/05 - Present
日本口腔衛生学会　地域口腔保健委員会委員

2017/06 - Present
日本口腔衛生学会　査読委員

2013/05 - Present
厚生労働省・事務局（口腔衛生学会）　歯科疾患実態調査集計・分析検討会委員

2024/11 - 2025/03
宮城県　みやぎ２１健康プラン有識者ワーキング委員

2023/04 - 2025/03
日本歯科衛生教育学会　研究倫理審査委員会外部委員

2019/04 - 2025/03
厚生労働省・事務局（三菱総合研究所）　医歯薬連携による糖尿病重症化予防モデル事業ワーキンググループ委員

2021/07 - 2024/03
厚生労働省・事務局（みずほ情報総研）　地方自治体等の歯科保健医療施策のための状況や各種取組等の把握・収集・分析及び情報提供の在り方検討委員会委員

2020/08 - 2024/03
日本口腔衛生学会　研修委員会委員

2021/05 - 2023/05
日本口腔衛生学会　認定制度運営委員会・専門医認定部会委員

2021/05 - 2023/05
厚生労働省　歯科口腔保健の推進に関する専門委員会参考人

2022/09 - 2023/03
宮城県　8020運動及び歯科口腔保健の推進に関する検討評価委員会委員

2021/12 - 2023/03
厚生労働省・事務局（NTTデータ）　歯周病予防に関する実証事業に係る調査研究等一式作業委員会委員

2020/09 - 2023/03
福岡市　口腔機能向上検討会委員

2013/04 - 2019/03

Show all ︎Show first 5

Professional Memberships 6

日本老年歯科医学会
THE INTERNATIONAL ASSOCIATION FOR DENTAL RESEARCH
日本歯科衛生学会
JAPANESE SOCIETY OF PUBLIC HEALTH
JAPANESE SOCIETY FOR ORAL HEALTH
JAPAN EPIDEMIOLOGICAL ASSOCIATION

︎Show all ︎Show first 5

Research Interests 20

EBPM
データサイエンス
医療経済
ヘルスサービスリサーチ
レセプトデータ
RWD
Non-communicable diseases
医療費
笑い
予防医学
oral care
COPD
Social epidemiology
dysphagia
介護保険
Geriatrics
Dementia
Epidemiology
Public Health
Periodontal disease

Research Areas 2

Life sciences / Healthcare management, medical sociology /
Life sciences / Community dentistry /

Awards 21

ポスター賞（共同演者）

2025/09　第25回日本歯科医学会学術大会
老年歯科医学賞（渡邉郁馬賞）（共同演者）

2025/06　日本老年歯科医学会第36回学術大会
奨励賞

2025/02　日本疫学会
学術賞

2024/12　東北大学歯学会
演題賞（共同演者）

2024/10　第83回日本公衆衛生学会総会
Young Leaders Overseas Program（Adoption）

2024/09　Tohoku University
功績賞（研究部門）

2024/06　東北大学大学院歯学研究科
IADR Aubrey Sheiham Award for Distinguished Research in Dental Public Health Sciences

2024/03　The 102th IADR General Session & Exhibition
優秀演題賞（非専門家部門）（共同演者）

2022/11　日本臨床疫学会第5回年次学術大会
IADR BEHSR Outstanding Student Abstract Award

2022/06　The 100th IADR General Session & Exhibition
JADR/GC Young Investigator Award

2022/06　The 100th IADR General Session & Exhibition
優秀発表賞（共同演者）

2022/05　第71回日本口腔衛生学会総会
The Japanese Society for Oral Health Academic Award "LION Award".

2019/05
論文奨励賞（共同演者）

2017/06　第66回日本口腔衛生学会総会　地域住民における口腔の健康状態と生活習慣病の関連性の検討－久山町研究－
優秀発表賞（共同演者）

2016/09　第38回九州口腔衛生学会総会
The IADR BEHSR student abstract award

2016/06　The 94th IADR General Session & Exhibition
The J. Morita Post-doctoral Award for Junior Investigators for Geriatric Oral Research (First Prize)

2016/06　The 94th IADR General Session & Exhibition.
Joseph Lister Award

2015/10　The 63rd Annual Meeting of Japanese Association for Dental Research
優秀発表賞（共同演者）

2015/09　第37回九州口腔衛生学会総会
The Best Presenter Award

2014/07　The 36th General Meeting of Kyushu Society for Oral Health.
研究者育成プログラム（採択）

2012/10　東北大学大学院歯学研究科

Show all ︎Show 5

Papers 209

Oral Frailty and Social Frailty Among Older Japanese

Isi Susanti, Hazem Abbas, Kenji Takeuchi, Jun Aida, Ken Osaka

Gerodontology　2026/02/17

DOI： 10.1111/ger.70056 　
Role of Posterior Occlusal Support in the Development of Frailty Among Japanese Adults: A Longitudinal Cohort Study

Takashi Miyano, Taro Kusama, Yudai Tamada, Ken Osaka, Kenji Takeuchi

Geriatrics & Gerontology International　2026/02

DOI： 10.1111/ggi.70405 　
Clustering Analysis of Partial Tooth Loss Patterns and Their Association With Cardiovascular Health Using a Japanese Claims Database

Takashi Miyano, Taro Kusama, Manami Hoshi-Harada, Ken Osaka, Kenji Takeuchi

Journal of the American Medical Directors Association　2026/02

DOI： 10.1016/j.jamda.2025.106046 　
Unfilled Prescriptions in Japan: A 10‐Year Retrospective Analysis

Yuki Kataoka, Yudai Tamada, Takahiro Tabuchi, Kenji Takeuchi

Pharmacoepidemiology and Drug Safety　35　(2)　2026/01/16
Publisher: Wiley
DOI： 10.1002/pds.70324 　

ISSN： 1053-8569

eISSN： 1099-1557

More details Close

ABSTRACT Purpose To describe primary medication non‐adherence (PMN; failure to fill newly prescribed medications) patterns in Japan over a decade under universal healthcare coverage. Methods We conducted a retrospective cohort study using the DeSC Healthcare database, which integrates pharmacy dispensing records with Japanese medical claims data. We analyzed medical claims with prescription fees from April 2014 to September 2023. PMN was defined as the absence of a pharmacy dispensing record following a documented prescription issuance. Results We analyzed 2 620 639 medical claims from 1 935 948 unique patients. The overall PMN proportion was 4.9%, with 5.6% in 2014 and 4.3% in 2023. Age‐specific subgroup analysis showed proportions ranging from 4.5% to 5.2%. Across all 7 days of the week, proportions ranged from 4.9% to 5.1%. Disease‐specific analysis showed proportions ranging from 4.0% (hypertension) to 7.0% (spinal disorders). Conclusions PMN remained around 5% over the study period. Health insurers should consider developing notification mechanisms to alert healthcare providers about unfilled prescriptions. Future research should evaluate the impact of electronic prescribing systems.
Switching from cigarette use to dual use with heated tobacco products and severe periodontitis risk. International-journal

Chihiro Shiota, Kenji Takeuchi, Yudai Tamada, Taro Kusama, Ken Osaka, Takahiro Tabuchi

Frontiers in oral health　7　1765902-1765902　2026

DOI： 10.3389/froh.2026.1765902 　

More details Close

INTRODUCTION: Severe periodontitis is a major global health concern, yet the impact of switching from combustible cigarettes to dual use of combustible cigarettes and heated tobacco products on periodontal status remains unclear. This study aimed to examine whether changes in smoking status influence the risk of severe periodontitis among Japanese adults. METHODS: We conducted a longitudinal analysis using panel data from the Japan COVID-19 and Society Internet Survey. Participants were daily combustible cigarette smokers with periodontitis in 2021 and were followed through 2023. Smoking trajectories between 2021 and 2022 were categorized as: (1) continuous combustible cigarette smokers, (2) dual users (heated tobacco product-dominant), (3) dual users (combustible cigarette-dominant), and (4) quitters/reduced smokers. Severe periodontitis in 2023 was defined using validated self-reported criteria. Modified Poisson regression with robust variance was applied to estimate risk ratios and 95% confidence intervals (95% CIs), adjusting for potential confounders (age, sex, educational attainment, occupational status, marital status, equivalent income, alcohol consumption, diabetes mellitus status, periodontal pain, and smoking frequency). RESULTS: A total of 193 participants (mean age 57.6 years; men 67.9%) were analyzed. Over 2 years, 61.1% developed severe periodontitis. Compared to continuous combustible cigarette smokers, the adjusted risk of severe periodontitis was 1.19 times (95% CI: 0.67-2.11), 1.41 times (95% CI: 1.04-1.91), and 0.99 times (95% CI: 0.76-1.28) higher for dual users (heated tobacco product-dominant), dual users (combustible cigarette-dominant), and quitters/reduced smokers, respectively. Sensitivity analyses using inverse probability weighting yielded consistent findings. CONCLUSION: Switching from daily combustible cigarette smoking to dual use with heated tobacco products may increase the risk of severe periodontitis. Combining combustible cigarettes with heated tobacco products, regardless of the frequency of combustible cigarette smoke, should not be considered a harm-reduction strategy in dental and public health practice.
With the Rise of Right‐Wing Governments, Why a One‐Time “50% Health Tax” Will Be a Hard Sell and How It Could Be Implemented

Hazem Abbas, Maha El Tantawi, Manami Hoshi‐Harada, Kenji Takeuchi, Ken Osaka, Carol C. Guarnizo‐Herreño, Marco A. Peres

Community Dentistry and Oral Epidemiology　2025/12/30

DOI： 10.1111/cdoe.70051 　
Tooth loss, dental prosthesis use, and cause-specific mortality in older Japanese adults: a 7-year cohort study

Faiz Abdurrahman, Taro Kusama, Yudai Tamada, Sakura Kiuchi, Masashige Saito, Toshiyuki Ojima, Jun Aida, Katsunori Kondo, Ken Osaka, Kenji Takeuchi

Scientific Reports　15　(1)　2025/11/19
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-025-24357-1 　

eISSN： 2045-2322
Oral health and happiness after 3-years with causal mediation of oral functions

Hazem Abbas, Kenji Takeuchi, Taro Kusama, Sakura Kiuchi, Katsunori Kondo, Ken Osaka

Journal of Dentistry　162　106036-106036　2025/11
Publisher: Elsevier BV
DOI： 10.1016/j.jdent.2025.106036 　

ISSN： 0300-5712
Willingness to pay and its determinants for missing tooth replacement among older adults: A cross-sectional study in Japan

Sakura Kiuchi, Taro Kusama, Jun Aida, Ken Osaka, Kenji Takeuchi

The Journal of Prosthetic Dentistry　2025/11

DOI： 10.1016/j.prosdent.2025.10.041 　
Oral Health and Social Isolation After 6 Years: Mediation of Oral Functions

Hazem Abbas, Kenji Takeuchi, Taro Kusama, Sakura Kiuchi, Ken Osaka

Community Dentistry and Oral Epidemiology　2025/10/26
Publisher: Wiley
DOI： 10.1111/cdoe.70035 　

ISSN： 0301-5661

eISSN： 1600-0528

More details Close

ABSTRACT Objectives Tooth loss was longitudinally associated with social isolation. The absence of dental prosthesis use was an additional risk factor. However, the mediating pathways for this association are unknown. The aim of this cohort study was to estimate the mediating effect of three oral functions: speaking, smiling and chewing observed at baseline on the association between oral health at baseline and social isolation after 6 years of follow‐up. Methods The 2010–2016 panel data from 6103 functionally independent participants aged ≥ 65 years who were not socially isolated at baseline was used from the Japan Gerontological Evaluation Study (JAGES). Causal mediation analysis using parametric logistic regression models was used to calculate the natural direct effect (NDE), the natural indirect effect (NIE), and the total effect. Social isolation was derived from a 5‐point index and dichotomised (0/3 = not isolated, 4/5 = isolated). The confounders observed at baseline were age, sex, educational attainment, income, activities of daily living, living area, and having depressive symptoms assessed using the geriatric depression scale (GDS‐15). Results The mean age of the participants was 72.4 years (SD = ±5.1), and 44.7% were males. Social isolation was observed at follow‐up among 3.6% of participants ( n = 220). The cumulative incidence rate of socially isolated participants among those with ≥ 20 teeth was 2.9% increasing gradually to 3.2%, 3.5%, 3.7% and 7.2% among those with 10–19 teeth and used dental prosthesis, 10–19 teeth and did not use the dental prosthesis, 0–9 teeth and used dental prosthesis, and 0–9 teeth and did not use the dental prosthesis respectively. Compared with those with ≥ 20 teeth, having difficulty in speaking [NIE odds ratio (OR) = 1.02, 95% confidence interval (CI) = 0.93–1.11], problems in smiling (NIE OR = 1.02, 95% CI = 0.93–1.10) and difficulty in chewing (NIE OR = 1.04, 95% CI = 0.94–1.14) might have mediated the association for those with 10–19 teeth and used dental prosthesis as well as for those with 10–19 teeth without dental prosthesis (NIE OR = 1.02, 95% CI = 0.94–1.10), (NIE OR = 1.02, 95% CI = 0.93–1.11) and (NIE OR = 1.02, 95% CI = 0.93–1.11) respectively. While they might not have mediated the association for those with 0–9 teeth with and without dental prosthesis use. Conclusion With low precision and uncertain estimates, limited oral function might have mediated the association between tooth loss (10–19 with and without dental prosthesis use groups) and social isolation over 6 years. It was uncertain whether a mediation effect of oral functions was observed for those with 0–9 teeth with and without dental prosthesis use.
No Cost Sharing for Public Assistance Recipients and Health Service Usage in Japan. International-journal

Chihiro Shiota, Kenji Takeuchi, Taro Kusama, Yudai Tamada, Futoshi Oda, Megumi Maeda, Ken Osaka, Haruhisa Fukuda

JAMA health forum　6　(10)　e253713　2025/10/03

DOI： 10.1001/jamahealthforum.2025.3713 　

More details Close

IMPORTANCE: In Japan, the public assistance (PA) system for low-income individuals provides medical aid that covers all health care costs (no cost sharing). However, little is known about how health care service utilization changes after PA certification. OBJECTIVE: To examine the trajectories of outpatient medical and dental care utilization among PA recipients before and after PA certification. DESIGN, SETTING, AND PARTICIPANTS: Longitudinal data from a municipality in Japan participating in the Longevity Improvement Fair Evidence Study from 2017 to 2022 were used. Generalized estimating equations were used to calculate absolute differences and relative ratios in health care service utilization before and after PA certification. An interrupted time-series analysis (ITSA) was performed to examine the trends in health care service use based on monthly panel data. The elasticity of each health care service was also calculated. The participants were individuals who switched from National Health Insurance to PA and were 20 years and older. The analysis was performed in 2024. EXPOSURE: PA certification. MAIN OUTCOMES AND MEASURES: Outpatient medical and dental care expenditures, visits, and unit costs per month from 1 year before to 1 year after PA certification. RESULTS: Overall, 2893 study participants were analyzed (mean [SD] age, 54.2 [15.3] years; 1501 women [51.9%]). For outpatient medical care, the mean (SD) expenditures per month before and after PA certification were \16 565 (\53 159) and \22 442 (\53 443), respectively (converting to US dollars using the rate of \100 = $0.68 based on 2025 rates). For outpatient dental care, the mean (SD) expenditures per month before and after PA certification were \1727 (\3726) and \3978 (\6894), respectively. The ITSA showed significant increases in outpatient expenditure immediately after PA certification: \2681 (95% CI, 317-5046) and \2330 (95% CI, 1896-2764) in medical and dental care, respectively. CONCLUSIONS AND RELEVANCE: This study found that eliminating cost sharing under a PA system was associated with increased outpatient health service use, particularly for dental care. These findings highlight financial barriers to care among low-income populations and suggest that no cost-sharing policies can improve access but may require policy measures to address overuse.
Frequency of laughter and depression onset among older adults: A 6-year longitudinal study from the Japan Gerontological Evaluation Study

Yudai Tamada, Masashige Saito, Tetsuya Ohira, Kokoro Shirai, Chikae Yamaguchi, Kohei Hasebe, Katsunori Kondo, Ken Osaka, Kenji Takeuchi

Journal of Affective Disorders　2025/09

DOI： 10.1016/j.jad.2025.120209 　
Socioeconomic Inequalities in Oral Frailty Among Older Adults: A Causal Mediation Analysis on the Role of Prevention From Tooth Loss

Mieko Fujita, Kenji Takeuchi, Yudai Tamada, Taro Kusama, Tatsuo Yamamoto, Katsunori Kondo, Ken Osaka

Journal of Oral Rehabilitation　2025/08/27

DOI： 10.1111/joor.70042 　
Chewing difficulty, swallowing problems, xerostomia and cause‐specific mortality among older adults: A 7‐year follow‐up JAGES cohort study

Taro Kusama, Yudai Tamada, Sakura Kiuchi, Masashige Saito, Toshiyuki Ojima, Jun Aida, Katsunori Kondo, Ken Osaka, Kenji Takeuchi

Geriatrics & Gerontology International　2025/08/25

DOI： 10.1111/ggi.70150 　
Perceived indoor thermal environment and depressive symptoms among older adults in the Japan Gerontological Evaluation Study

Maho Iwata, Anna Kinugawa, Masamichi Hanazato, Katsunori Kondo, Ken Osaka, Kenji Takeuchi

SCIENTIFIC REPORTS　15　(1)　2025/08/22

DOI： 10.1038/s41598-025-15922-9 　

ISSN： 2045-2322
Association between infrequent denture cleaning and all-cause mortality risk among community-dwelling older adults: Findings from a six-year cohort study. International-journal

Taro Kusama, Jun Aida, Ken Osaka, Kenji Takeuchi

The Journal of prosthetic dentistry　2025/07/25

DOI： 10.1016/j.prosdent.2025.07.005 　

More details Close

STATEMENT OF PROBLEM: Although dental prostheses provide important clinical benefits for individuals with tooth loss, removable dentures can also serve as reservoirs for pathogenic microorganisms. Although denture cleanliness has been associated with pneumonia risk among older adults in residential or hospital settings, its relationship with adverse health outcomes among community-dwelling older adults remains unclear. PURPOSE: The purpose of this cohort study was to investigate the association between the frequency of denture cleaning and the risk of all-cause mortality among community-dwelling older adults. MATERIAL AND METHODS: Data from the Japan Gerontological Evaluation Study were evaluated with participants aged ≥65 years who used removable dentures being included. The self-reported frequency of denture cleaning (daily versus nondaily) was used as the exposure variable, and all-cause mortality as the outcome. Cox proportional hazards models, adjusted for potential confounders, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Among 45 301 participants (mean age=75.8 years [standard deviation=6.4]; 46.4% male), the all-cause mortality rate was 2.42 per 100 person-years. Overall, 4.5% of participants reported not cleaning their dentures daily. After adjustment, nondaily denture cleaning was significantly associated with higher all-cause mortality risk compared with daily cleaning (HR=1.18, 95% CI: 1.06 to 1.30). CONCLUSIONS: Daily denture cleaning was found to be critical for preventing adverse health outcomes associated with denture use among community-dwelling older adults. Dental professionals should emphasize proper denture hygiene in clinical practice.
Removable partial denture, complete denture, and fixed partial denture use and health-related quality of life among older adults with tooth loss: A JAGES cross-sectional study.

Manami Hoshi-Harada, Kenji Takeuchi, Taro Kusama, Jun Aida, Hiroshi Egusa, Ken Osaka

Journal of prosthodontic research　2025/06/24

DOI： 10.2186/jpr.JPR_D_24_00286 　

More details Close

PURPOSE: To investigate the association of removable partial denture (RPD)/complete denture (CD) and fixed partial denture (FPD) use with health-related quality of life (HRQoL), evaluated using the EuroQol 5-dimension, 5-level instrument (EQ-5D-5L) among older adults with tooth loss. METHODS: Cross-sectional data from the 2022 Japan Gerontological Evaluation Study. Participants were classified as RPD/CD users, FPD users, or nonusers. Generalized linear regression models stratified by the number of teeth were used to explore the association of RPD/CD and FPD use with the HRQoL evaluated using the EQ-5D-5L. The interactions among the number of teeth, RPD/CD, and FPD use were examined. RESULTS: After adjusting for all covariates, RPD/CD and FPD users with 5-19 teeth had higher predicted HRQoL utility scores than nonusers (RPD/CD [n=14,297]: 0.837 vs. 0.850; FPD [n=7,476]: 0.858 vs. 0.861 [nonusers vs. users]). The interaction between number of teeth and RPD/CD and FPD use revealed that differences in HRQoL between users and nonusers were greater among those with 1-14 teeth for RPD/CD use and among those with 10-14 teeth for FPD use (RPD/CD: β = -0.008, P < 0.01; FPD: β = -0.008, P = 0.183). CONCLUSIONS: RPD/CD and FPD users with 5-19 teeth had a higher HRQoL than nonusers, with differences appearing to depend on the number of teeth. The World Health Organization has promoted the incorporation of oral health into universal health coverage (UHC). Given the minimal HRQoL difference between CD users and nonusers among edentulous individuals, unconventional dentures may merit inclusion in UHC.
Association of Number of Teeth Present With Nutrient Intake and Food Group Consumption. International-journal

Mayuka Asaeda, Rumi Nishimura, Shino Suma, Mineko Tsukamoto, Yuka Kadomatsu, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Chiho Goto, Nahomi Imaeda, Kenji Wakai, Nishiki Arimoto, Tomoko Maehara, Mariko Naito

Journal of oral rehabilitation　2025/05/19

DOI： 10.1111/joor.14011 　

More details Close

BACKGROUND: Several studies have examined the impact of tooth loss on nutrient intake, yielding mixed results. OBJECTIVES: This cross-sectional study aimed to investigate the association among the number of teeth present, nutrient intake and food group consumption in Japanese adults with no history of the four major diseases (diabetes, cancer, heart disease and stroke). METHODS: Data were obtained from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study conducted in the Shizuoka and Daiko areas. Participants completed a self-administered questionnaire on their number of teeth, medical history (diabetes, cancer, heart disease and stroke), education level, employment status and lifestyle factors, such as diet, smoking history and exercise habits. The number of teeth was classified into four groups: 0 teeth, 1-19 teeth, 20-27 teeth and 28-32 teeth. RESULTS: A total of 8912 individuals included in the analysis had a mean age ± SD of 51.7 ± 9.5 years, with women accounting for 53.6% of the total. In adult men, the number of teeth was negatively associated with the intake of vitamin D, n-3 highly unsaturated fatty acid intake and seafood, while in women, bread consumption was positively associated with the number of teeth. CONCLUSIONS: These findings suggest that the number of teeth is independently associated with poor nutritional status in Japanese adults with no history of the four major diseases.
Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database. International-journal

Takashi Miyano, Yudai Tamada, Taro Kusama, Ken Osaka, Kenji Takeuchi

Scientific reports　15　(1)　16693-16693　2025/05/14

DOI： 10.1038/s41598-025-01846-x 　

More details Close

Cardiovascular disease (CVD) is a global health concern; however, its association with the posterior occlusal contact remains unexplored. This study investigated the association between posterior occlusal contact and CVD risk in a large Japanese cohort and examined whether the loss of posterior occlusal contact in individuals with at least 20 teeth was a distinct CVD risk factor. Using Japanese health insurance claims data from 1,209,997 adults aged ≥ 40 years without prior CVD history (April 2016-March 2022), participants were categorized using the Eichner classification to assess posterior occlusal contact. Over an average follow-up period of 36.2 months, 51,471 participants developed CVD. Compared with individuals with full occlusal contact (Eichner A), those with reduced contact (Eichner B and C) demonstrated significantly higher CVD risks, with hazard ratios of 1.25 (95% confidence interval [CI]: 1.19-1.32) and 1.31 (95% CI: 1.17-1.46), respectively. In a subgroup analysis of participants with ≥ 20 teeth, reduced occlusal contact from Eichner A2 to B2 was associated with an increased risk of CVD, especially in those aged 40-59 years. These findings suggest that reduced posterior occlusal contact may contribute to increased CVD risk, emphasizing the importance of preserving natural occlusal support for CVD prevention.
Combined association of social isolation and loneliness with frailty onset among independent older adults: A JAGES cohort study

Mamoru Sato, Manami Hoshi-Harada, Kenji Takeuchi, Taro Kusama, Takaaki Ikeda, Sakura Kiuchi, Masashige Saito, Naoki Nakaya, Ken Osaka

Archives of Gerontology and Geriatrics　2025/05

DOI： 10.1016/j.archger.2025.105914 　
Response to Letter to the Editor: Stepwise rather than linear trend in prevalence of secondhand tobacco exposure among children

Yudai Tamada, Kenji Takeuchi, Takahiro Tabuchi

Nicotine and Tobacco Research　2025/04/28

DOI： 10.1093/ntr/ntaf090 　
Frequency of Conversation, Laughter and Other Vocalising Opportunities in Daily Life and Maximum Tongue Pressure: The Goto Longevity Study

Mako Nagayoshi, Mami Tamai, Kenji Takeuchi, Hirotomo Yamanashi, Jun Koyamatsu, Fumiaki Nonaka, Kenichi Nobusue, Yukiko Honda, Shin‐ya Kawashiri, Yasuhiro Nagata, Takahiro Maeda

Journal of Oral Rehabilitation　2025/04/22

DOI： 10.1111/joor.13979 　
日本人成人を対象とした睡眠時間とう蝕との関連 JACSIS2023横断研究

白井凜, 衣川安奈, 塩田千尋, 原田真奈実, 草間太郎, 竹内研時, 小坂健

口腔衛生学会雑誌　75　(増刊)　181-181　2025/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831

eISSN： 2189-7379
睡眠時間と重度歯周病との関連 JACSIS2023横断研究

金高麗奈, 衣川安奈, 塩田千尋, 原田真奈実, 草間太郎, 竹内研時, 小坂健

口腔衛生学会雑誌　75　(増刊)　181-181　2025/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831

eISSN： 2189-7379
睡眠時間と歯の痛みとの関連 JACSIS2023横断研究

畑中大輝, 衣川安奈, 塩田千尋, 原田真奈美, 草間太郎, 竹内研時, 小坂健

口腔衛生学会雑誌　75　(増刊)　182-182　2025/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831

eISSN： 2189-7379
Differences in health care expenditure due to the comorbidity status of periodontal disease and diabetes mellitus

Anna Kinugawa, Kenji Takeuchi, Yudai Tamada, Taro Kusama, Misuzu Sato, Megumi Maeda, Fumiko Murata, Ken Osaka, Haruhisa Fukuda

Journal of Periodontology　2025/01/18

DOI： 10.1002/JPER.24-0496 　
公的統計における咀嚼に関連する食行動指標の概況と意義について

深井穫博, 大内章嗣, 福田英輝, 岡田寿朗, 佐々木健, 安藤雄一, 小川祐司, 竹内研時, 山中史教, 小畑充彦, 長優子, 田所大典, 皆川久美子, 江藤優希, 神原正樹, 宮崎秀夫, 嶋崎義浩, 花田信弘

口腔衛生学会雑誌　75　(1)　31-36　2025/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831

eISSN： 2189-7379
日本人における臼歯部咬合と認知症発症との関連 JMDCデータベースを用いた縦断研究

宮野貴士, 玉田雄大, 草間太郎, 竹内研時

Journal of Epidemiology　35　(Suppl.)　178-178　2025/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Evidence-based Decision-making Regarding Fluoride Application in Recent Years Part 2: Data Interpretation to Address Misunderstandings

MATSUYAMA Yusuke, FURUTA Michiko, MAKI Yoshinobu, ISHIZUKA Yoichi, TAKEUCHI Kenji, TADOKORO Daisuke, MORIKI Daisuke, TAGUCHI Nobuhiro, AIDA Jun

JOURNAL OF DENTAL HEALTH　75　(3)　124-131　2025
Publisher: Japanese Society for Oral Health
DOI： 10.5834/jdh.75.3_124 　

ISSN： 0023-2831

eISSN： 2189-7379

More details Close

This paper is the second part of a report on recent scientific evidence regarding fluoride application. 1. The effectiveness of school-based fluoride mouthrinse in Japan: We explained that the effectiveness of health policies in real-world settings could not be evaluated based on randomized controlled trials alone, and school-based fluoride mouth rinse is necessary as a population strategy to reduce health inequalities. 2. Chlorhexidine application for caries prevention and the safety of fluoride toothpaste with titanium materials for anaphylactic shock: We reviewed the scientific evidence on the caries-preventing effects of and adverse events caused by chlorhexidine. 3. Fluoride application and allergies/anaphylaxis: We reported the unlikeliness of fluoride application causing anaphylactic shock, and stated that fluoride should be applied carefully to prevent acute fluoride toxicity. 4. Fluoride application and scientific evidence on caries prevention for infants and toddlers: We explained that “evidence of the cause of disease” and “evidence of preventing the cause” needed to be considered separately. 5. Necessity of advocates for fluoride application, including water fluoridation: We explained that it is necessary to continue to advocate for public-based scientific evidence as the role of experts in public health policy in the group decision-making process.
Bidirectional longitudinal associations between subjective oral health and subjective well-being. International-journal

Taro Kusama, Takamasa Komiyama, Kenji Takeuchi, Wael Sabbah, Ken Osaka, Jennifer E Gallagher

Archives of gerontology and geriatrics　131　105740-105740　2024/12/31

DOI： 10.1016/j.archger.2024.105740 　

More details Close

OBJECTIVE: This study investigated the bidirectional longitudinal association between subjective oral health (SOH) and subjective well-being (SWB) over time. METHODS: This cohort study was based on a four-wave surveys conducted by the English Longitudinal Study of Aging. SOH was measured by oral impacts on daily performance (OIDP), self-rated oral health (SROH), and SWB was measured by the Center for Epidemiologic Studies-Depression (CES-D) scale, Control, Autonomy, Self-Realization, and Pleasure (CASP-19), and satisfaction with life scale (SWLS). To evaluate the bidirectional associations between SOH and SWB, separate models were created using SOH and SWB as the outcome and exposure, respectively. Additionally, the synchronous and lagged effects of exposure on outcomes were checked by employing exposures measured at different time points. A generalized estimating equation model was fitted, including the exposure variables, outcome variables in the previous wave, and baseline covariates. RESULTS: Among 4,510 participants (mean age=61.7 years [1SD=7.9], men=43.1 %), 8.1 %, 18.2 %, 14.3 %, 30.5 %, and 25.0 % had poor SOH and SWB as measured by OIDP, SROH, CES-D, CASP-19, and SWLS at baseline, respectively. The results of the regression models with all combinations of SOH and SWB measures showed that poor conditions of SOH or SWB were significantly associated with poor conditions of the other measures (all p < 0.05). In almost all combinations of SOH and SWB measures, the synchronous effect was stronger than the lagged effect. CONCLUSION: SOH and SWB are closely linked, and comprehensive care that considers oral health could contribute to well-being later in life.
School‐Based Fluoride Mouth‐Rinse Programs and Dental Caries Treatment Expenditure: An Ecological Study of the NDB Open Data Japan

Daisuke Tadokoro, Kazue Honda, Taro Kusama, Kenji Takeuchi, Ken Osaka, Jun Aida

Community Dentistry and Oral Epidemiology　2024/12/25

DOI： 10.1111/cdoe.13024 　
Longitudinal association between posterior occlusal contact and dementia development in a large retrospective cohort study using a Japanese claims database

Takashi Miyano, Yudai Tamada, Taro Kusama, Ken Osaka, Kenji Takeuchi

Scientific Reports　14　(1)　2024/11/11
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-024-79399-8 　

eISSN： 2045-2322
Public Periodontal Screening Increases Subsequent Regular Dental Visits: The Life Study

Y. Tamada, T. Kusama, M. Maeda, F. Murata, K. Osaka, H. Fukuda, K. Takeuchi

JDR Clinical & Translational Research　2024/09/25

DOI： 10.1177/23800844241275859 　
Secondhand tobacco exposure assessed using urinary cotinine among 10-year-old children in Japan: An 11-year repeated cross-sectional study. International-journal

Yudai Tamada, Kenji Takeuchi, Takahiro Tabuchi

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco　2024/09/19

DOI： 10.1093/ntr/ntae220 　

More details Close

INTRODUCTION: The emergence of heated tobacco products (HTPs) has made it important to monitor HTP-generated aerosols in addition to combustible cigarette (CC) smoke as a source of secondhand tobacco (SHT) exposure. We investigated the trend of SHT exposure in school-aged children and assessed whether SHT exposure depended on household tobacco use status. METHODS: This repeated cross-sectional study from 2011 to 2021 (15,927 participants) was based on data from an annual survey of fourth-grade students (aged 10 years) in Kumagaya City, Japan. In addition to a questionnaire which includes questions about household tobacco use status, we measured urinary cotinine levels of each participant by their first morning urine sample to objectively assess SHT exposure. We defined the participants with urinary cotinine levels ≥5.0 ng/ml as being exposed to SHT. RESULTS: The prevalence of SHT exposure decreased over the 11-year period from 18.6% in 2011 to 5.3% in 2021. It was significantly higher in households with tobacco users than without tobacco users (t-test P<0.001). Prevalence of SHT exposure was 1.4% among the 68.1% of households not using tobacco, 22.9% among the 16.5% using only CC, 3.1% among the 12.3% using only HTP and 27.6% among the 3.9% of households using CC and HTP. CONCLUSIONS: While the prevalence of SHT exposure showed a decreasing trend from 2011 to 2021, the prevalence of SHT exposure was higher in children with household members using tobacco products, regardless of the type of tobacco product, than in those without tobacco users. IMPLICATIONS: This study observed that the prevalence of SHT exposure was higher among children in households with tobacco users than among those without tobacco users, regardless of the type of tobacco product. Our findings highlight the importance of advocating that HTPs do not reduce the likelihood of SHT exposure to bystanders.
Number of Teeth and Dementia-free Life Expectancy: A 10-Year Follow-Up Study From the Japan Gerontological Evaluation Study. International-journal

Sakura Kiuchi, Yusuke Matsuyama, Kenji Takeuchi, Taro Kusama, Upul Cooray, Ken Osaka, Jun Aida

Journal of the American Medical Directors Association　25　(11)　105258-105258　2024/09/11

DOI： 10.1016/j.jamda.2024.105258 　

More details Close

OBJECTIVES: Previous studies have reported that tooth loss is associated with an increased risk of dementia; however, few have explored the association between number of teeth and dementia-free and total life expectancies. We investigated whether having more teeth is associated with longer dementia-free and total life expectancies. DESIGN: A 10-year follow-up prospective cohort study from 2010 to 2020. SETTING AND PARTICIPANTS: Functionally independent older adults aged ≥65 years living in 9 municipalities in Japan. METHODS: The exposure was the number of teeth (≥20, 10-19, 1-9, and 0). Dementia onset and mortality within the 10-year follow-up were used as the outcome. Dementia-free and total life expectancies according to the number of teeth were derived from multistate modeling estimates. RESULTS: A total of 44,083 participants were included (men: 46.8%). The mean age was 73.7 years (standard deviation [SD] = 6.0). During follow-up, 17.3% and 21.4% of the participants experienced the onset of dementia and death, respectively. Having fewer teeth was associated with dementia (hazard ratio [HR], 1.14; 95% confidence interval [CI], 1.07-1.22, 10-19 teeth; HR, 1.15; 95% CI, 1.08-1.22, 1-9 teeth; HR, 1.13; 95% CI, 1.05-1.21, 0 teeth) and death (HR, 1.13; 95% CI, 1.05-1.22, 10-19 teeth; HR, 1.27; 95% CI, 1.19-1.37, 1-9 teeth; HR, 1.47; 95% CI, 1.36-1.59, 0 teeth) compared with having ≥20 teeth. Dementia-free life expectancies at the age of 65 years were 16.43 years and 18.88 years with ≥20 teeth, and 14.40 years and 17.12 years with 0 teeth for men and women, respectively. The total life expectancies at the age of 65 were 17.84 years and 22.03 years with ≥20 teeth, and 15.42 years and 19.79 years with 0 teeth for men and women, respectively. CONCLUSIONS AND IMPLICATIONS: Having more teeth was associated with longer dementia-free and total life expectancies.
Differences in cumulative long-term care costs by dental visit pattern among Japanese older adults: the JAGES cohort study. International-journal

Sakura Kiuchi, Kenji Takeuchi, Masashige Saito, Taro Kusama, Noriko Nakazawa, Kinya Fujita, Katsunori Kondo, Jun Aida, Ken Osaka

The journals of gerontology. Series A, Biological sciences and medical sciences　2024/08/05

DOI： 10.1093/gerona/glae194 　

More details Close

BACKGROUND: Long-term care (LTC) costs create burdens on aging societies. Maintaining oral health through dental visits may result in shorter LTC periods, thereby decreasing LTC costs; however, this remains unverified. We examined whether dental visits in the past 6 months were associated with cumulative LTC insurance (LTCI) costs. METHODS: This cohort study of the Japan Gerontological Evaluation Study targeted independent adults aged ≥65 years in 2010 over an eight-year follow-up. We used data from a self-reported questionnaire and LTCI records from the municipalities. The outcome was cumulative LTCI costs, and exposure was dental visits within 6 months for prevention, treatment, and prevention or treatment. A two-part model was used to estimate the differences in the predicted cumulative LTCI costs and 95% confidence intervals (CIs) for each dental visit. RESULTS: The mean age of the 8,429 participants was 73.7 years (standard deviation [SD]=6.0), and 46.1% were men. During the follow-up period, 17.6% started using LTCI services. The mean cumulative LTCI cost was USD 4877.0 (SD=19082.1). The predicted cumulative LTCI costs were lower among those had dental visits than among those who did not. The differences in predicted cumulative LTCI cost were -USD 1089.9 (95%CI = -1,888.5 - -291.2) for dental preventive visits, -USD 806.7 (95%CI = -1,647.4 - 34.0) for treatment visits, and -USD 980.6 (95%CI = -1,835.7 - -125.5) for preventive or treatment visits. CONCLUSIONS: Dental visits, particularly preventive visits, were associated with lower cumulative LTCI costs. Maintaining oral health through dental visits may effectively reduce the LTCI costs.
A principal component analysis of metabolome and cognitive decline among Japanese older adults: cross-sectional analysis using Tohoku Medical Megabank Cohort Study.

Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

Journal of epidemiology　2024/07/06

DOI： 10.2188/jea.JE20240099 　

More details Close

BackgroundDementia is the leading cause of disability and imposes a significant burden on society. Previous studies have suggested an association between metabolites and cognitive decline. Although the metabolite composition differs between Western and Asian populations, studies targeting Asian populations remain scarce.MethodsThis cross-sectional study used data from a cohort survey of community-dwelling older adults aged ≥ 60 years living in Miyagi, Japan, conducted by Tohoku Medical Megabank Organization between 2013 and 2016. Forty-three metabolite variables quantified using nuclear magnetic resonance spectroscopy were used as explanatory variables. Dependent variable was the presence of cognitive decline (≤ 23 points), assessed by the Mini-Mental State Examination. Principal component (PC) analysis was performed to reduce the dimensionality of metabolite variables, followed by logistic regression analysis to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for cognitive decline.ResultsA total of 2,940 participants were included (men: 49.0%, mean age: 67.6 years). Among them, 1.9% showed cognitive decline. The first 12 PC components (PC1-PC12) accounted for 71.7% of the total variance. Multivariate analysis showed that PC1, which mainly represented essential amino acids, was associated with lower odds of cognitive decline (OR = 0.89; 95% CI, 0.80-0.98). PC2, which mainly included ketone bodies, was associated with cognitive decline (OR = 1.29; 95% CI, 1.11-1.51). PC3, which included amino acids, was associated with lower odds of cognitive decline (OR = 0.81; 95% CI, 0.66-0.99).ConclusionAmino acids are protectively associated with cognitive decline, whereas ketone metabolites are associated with higher odds of cognitive decline.
Association between Number of Teeth and Eating out of Home: A 2019 Statistical Survey of the Japanese Representative Population. International-journal

Anna Kinugawa, Takafumi Yamamoto, Taro Kusama, Kenji Takeuchi, Ken Osaka

Nutrients　16　(13)　2024/07/01

DOI： 10.3390/nu16132102 　

More details Close

Eating out of home (EOH), with its diverse food options, can benefit those with difficulty preparing their meals, especially older adults. Oral health status may be a determinant of EOH, as food accessibility is influenced by oral health, but this association remains unclear. This cross-sectional study used merged data from two national statistical surveys conducted in 2019. Participants were individuals aged ≥ 65 years who responded to both surveys. The frequency of EOH (<once/week or ≥once/week) was the dependent variable. The number of teeth was used as the independent variable (≥20, 10-19, 1-9, and 0). Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using multivariate Poisson regression analysis to identify the association between EOH and the number of teeth, adjusting for possible confounders. We analyzed 2164 participants (mean age = 74.0, women 52.4%). Of these, 456 (21.1%) participants were EOH ≥ once/week; 1142 (52.8%) participants had ≥20 teeth. Compared to those with ≥20 teeth, those with <20 teeth had a lower prevalence of EOH ≥ once/week (10-19: PR = 0.89, 95% CI = 0.72-1.09, 1-9: PR = 0.67, 95% CI = 0.51-0.89, and 0: PR = 0.53, 95% CI = 0.36-0.77, respectively). We observed an association between fewer teeth and a lower frequency of EOH.
Validity of claims-based definition of number of remaining teeth in Japan: Results from the Longevity Improvement and Fair Evidence Study

Yudai Tamada, Taro Kusama, Sachiko Ono, Megumi Maeda, Fumiko Murata, Ken Osaka, Haruhisa Fukuda, Kenji Takeuchi

PLOS ONE　2024/05/07

DOI： 10.1371/journal.pone.0299849 　
Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study. International-journal

Chinatsu Kasahara, Takashi Tamura, Kenji Wakai, Yudai Tamada, Yasufumi Kato, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Asahi Hishida, Nahomi Imaeda, Chiho Goto, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Isao Oze, Yuriko N Koyanagi, Yohko Nakamura, Miho Kusakabe, Daisaku Nishimoto, Ippei Shimoshikiryo, Sadao Suzuki, Miki Watanabe, Etsuko Ozaki, Chie Omichi, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Keitaro Matsuo

Public health nutrition　1-40　2024/05/03

DOI： 10.1017/S1368980024000831 　

More details Close

OBJECTIVE: Although small fish are an important source of micronutrients, the relationship between their intake and mortality remains unclear. This study aimed to clarify the association between intake of small fish and all-cause and cause-specific mortality. DESIGN: We used the data from a cohort study in Japan. The frequency of the intake of small fish was assessed using a validated food frequency questionnaire. The hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality according to the frequency of the intake of small fish by sex were estimated using a Cox proportional hazard model with adjustments for covariates. SETTING: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. PARTICIPANTS: A total of 80,802 participants (34,555 males and 46,247 females), aged 35-69 years. RESULTS: During a mean follow-up of 9.0 years, we identified 2,482 deaths including 1,495 cancer-related deaths. The intake of small fish was statistically significantly and inversely associated with the risk of all-cause and cancer mortality in females. The multivariable-adjusted HRs (95% CIs) in females for all-cause mortality according to the intake were 0.68 (0.55-0.85) for intakes 1-3 times/month, 0.72 (0.57-0.90) for 1-2 times/week, and 0.69 (0.54-0.88) for ≥3 times/week, compared with the rare intake. The corresponding HRs (95% CIs) in females for cancer mortality were 0.72 (0.54-0.96), 0.71 (0.53-0.96), and 0.64 (0.46-0.89), respectively. No statistically significant association was observed in males. CONCLUSIONS: Intake of small fish may reduce the risk of all-cause and cancer mortality in Japanese females.
Regional Inequalities in Oral Frailty and Social Capital

T. Yamamoto, Y. Mochida, K. Irie, N. U. Altanbagana, S. Fuchida, J. Aida, K. Takeuchi, M. Fujita, K. Kondo

JDR Clinical & Translational Research　2024/04/23

DOI： 10.1177/23800844241238648 　
歯の本数と認知症を有さない余命期間との関連 JAGESコホート研究

木内桜, 松山祐輔, 竹内研時, 草間太郎, 小坂健, 相田潤

口腔衛生学会雑誌　74　(増刊)　122-122　2024/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
The association between objective and subjective oral health conditions and the presence of anorexia of aging among Japanese older Adults1

Taro Kusama, Kenji Takeuchi, Sakura Kiuchi, Jun Aida, Ken Osaka

Appetite　2024/04

DOI： 10.1016/j.appet.2024.107332 　
Dental prosthesis use moderates association between tooth loss and risk of depressive symptoms in older adults with severe tooth loss: The JAGES cohort trial.

Noriko Nakazawa, Kenji Takeuchi, Taro Kusama, Sakura Kiuchi, Katsunori Kondo, Ken Osaka

Journal of prosthodontic research　2024/03/13

DOI： 10.2186/jpr.JPR_D_23_00046 　

More details Close

PURPOSE: Depression is a leading cause of disability. Although tooth loss increases the risk of depressive symptoms, it is unclear whether dental prosthesis use moderates this risk. This study aimed to investigate whether dental prosthesis use moderates the association between tooth loss and new depressive symptoms in older adults. METHODS: This cohort study used data from the 2016 and 2019 Japan Gerontological Evaluation Study (JAGES). The participants were independent older adults aged ≥65 years without depressive symptoms in 2016. The onset of depressive symptoms in 2019 was the outcome variable. The explanatory variables were dental status (≥20 teeth, 10-19 teeth with or without dental prostheses, and 0-9 teeth with or without dental prostheses) in 2016. Risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using Poisson regression models with potential confounders as covariates. RESULTS: The analysis included 50,169 participants (mean age: 72.8 [standard deviation, 5.4] years). During follow-up, the incidence of depressive symptoms was 11.3%. Compared to those who had ≥20 teeth, the RR of depressive symptom onset was highest among those who had 0-9 teeth without dental prostheses (RR, 1.27; 95% CI, 1.04-1.56), after the adjustment for confounders. However, this risk was lower in those with 0-9 teeth and dental prostheses (RR, 1.08; 95% CI, 1.01-1.15). CONCLUSIONS: These data highlight the potential of dental prostheses as an important factor in reducing the risk of depressive symptoms among individuals with severe tooth loss.
Social disconnection and suicide mortality among Japanese older adults: A seven-year follow-up study. International-journal

Masashige Saito, Ryota Watanabe, Yudai Tamada, Kenji Takeuchi, Yukako Tani, Katsunori Kondo, Toshiyuki Ojima

Social science & medicine (1982)　347　116778-116778　2024/03/11

DOI： 10.1016/j.socscimed.2024.116778 　

More details Close

BACKGROUND: Few prospective studies have examined the association between social disconnection and late-life suicide. Therefore, we conducted a large-scale prospective study of older adults in Japan to examine differences in suicide mortality according to specific aspects of social disconnectedness. METHODS: We conducted a nationwide baseline survey of functionally independent older adults (age ≥65 years) from 12 municipalities in Japan from 2010 to 2011. We followed the participants (n = 46,144) for cause of death through December 2017 using vital statistics. Social disconnection was assessed based on the indicators of eating alone, a lack of instrumental/emotional support, no participation in community activities, and no contact with friends. We adopted Cox regression models with multiple imputation for missing values and calculated the population-attributable fraction (PAF). RESULTS: A total of 55 suicide deaths were recorded during an average follow-up of 7 years. Older adults with social disconnection had a marginally increased risk of suicide. The hazard ratio for eating alone vs. eating together was 2.81 (95% confidence interval [CI]: 1.47-5.37). The direction of these associations and point estimations did not largely change after controlling for depressive symptoms, an evident risk factor for suicidal behavior. The PAF indicated that eating alone was attributable to around 1800 (29%) of the suicide deaths among older adults annually in Japan. CONCLUSION: Avoidance of not only depressive symptoms, but also social disconnection including eating alone, is useful in suicide prevention among older adults.
Differences in prevalence of self‐reported oral hypofunction between older adult patients with rheumatoid arthritis and the general older population: A cross‐sectional study using propensity score matching

Yoko Kudo, Kenji Takeuchi, Taro Kusama, Toshihisa Kojima, Yuko Waguri‐Nagaya, Mako Nagayoshi, Katsunori Kondo, Kentaro Mizuta, Ken Osaka, Masayo Kojima

Journal of Oral Rehabilitation　2024/02/14

DOI： 10.1111/joor.13658 　
Tooth loss mediates the association between smoking and an increased risk of dementia among older adults: The <scp>JAGES</scp> prospective cohort study

Taro Kusama, Kenji Takeuchi, Sakura Kiuchi, Yudai Tamada, Takahiro Tabuchi, Ken Osaka

Journal of Clinical Periodontology　2024/02/07
Publisher: Wiley
DOI： 10.1111/jcpe.13959 　

ISSN： 0303-6979

eISSN： 1600-051X

More details Close

Abstract Aim Tooth loss has various causes; however, its cause‐specific effects on health outcomes remain unclear. This study evaluated whether the association between past/current smoking and risk of dementia was mediated by tooth loss. Materials and Methods This 9‐year‐follow‐up prospective cohort study targeted adults aged ≥65 years. Dementia incidence during 2013–2019, smoking status (never, past/current) in 2010 and the number of remaining teeth (≤19, ≥20) in 2013 were the outcome, exposure and mediator, respectively. We used causal mediation analysis to fit the Cox proportional hazards model and estimated the hazard ratio (HR) and 95% confidence interval (CI) of the natural indirect effect (NIE) of smoking on dementia incidence through tooth loss and their mediated proportions. Results Among 32,986 participants (mean age 72.6 years [1 SD = 5.4]; men 48.4%), the dementia incidence during follow‐up was 2.11/100 person‐years. Tooth loss significantly mediated the association between past/current smoking and dementia incidence; the NIE of fewer remaining teeth for past/current smokers compared to never smokers was HR = 1.03 (95% CI: 1.02–1.05), and the mediated proportion was 18.0%. Conclusions Tooth loss significantly mediates the association between past/current smoking and an increased risk of dementia among older adults.
Bivalent mRNA vaccine effectiveness against COVID-19 among older adults in Japan: a test-negative study from the VENUS study

Yudai Tamada, Kenji Takeuchi, Taro Kusama, Megumi Maeda, Fumiko Murata, Ken Osaka, Haruhisa Fukuda

BMC Infectious Diseases　24　(1)　2024/01/29
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12879-024-09035-3 　

eISSN： 1471-2334

More details Close

Abstract Background Bivalent COVID-19 vaccines have been implemented worldwide since the booster vaccination campaigns of autumn of 2022, but little is known about their effectiveness. Thus, this study holistically evaluated the effectiveness of bivalent vaccines against infection in older adults in Japan. Methods We adopted the test-negative design using COVID-19 test data of individuals, aged ≥ 65 years, residing in three municipalities in Japan, who underwent tests in medical institutions between October 1 and December 30, 2022. Logistic regression analyses were conducted to estimate the odds of testing positive according to vaccination status. Vaccine effectiveness was defined as (1 − odds ratio) × 100%. Results A total of 3,908 positive and 16,090 negative results were included in the analyses. Receiving a bivalent dose in addition to ≥ 2 monovalent doses was 33.6% (95% confidence interval [CI]: 20.8, 44.3%) more effective than receiving no vaccination, and 18.2% (95% CI: 9.4, 26.0%) more effective than receiving ≥ 2 monovalent doses but not receiving a bivalent vaccination. In addition, the effectiveness peaked at 14–20 days after administration and then gradually declined over time. Furthermore, a bivalent booster dose provided 18.6% (95% CI: 9.9, 26.5%) additional protection among those vaccinated with ≥ 2 monovalent doses, in the absence of a previous infection history. However, we did not find sufficient evidence of effectiveness of bivalent vaccines among previously infected older adults. Conclusions Bivalent vaccines are effective against COVID-19 infections among older adults without a history of infection.
Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. International-journal Peer-reviewed

Koyanagi Y.N, Nakatochi M, Namba S, Oze I, Charvat H, Narita A, Kawaguchi T, Ikezaki H, Hishida A, Hara M, Takezaki T, Koyama T, Nakamura Y, Suzuki S, Katsuura-Kamano S, Kuriki K, Nakamura Y, Takeuchi K, Hozawa A, Kinoshita K, Sutoh Y, Tanno K, Shimizu A, Ito H, Kasugai Y, Kawakatsu Y, Taniyama Y, Tajika M, Shimizu Y, Suzuki E, Hosono Y, Imoto I, Tabara Y, Takahashi M, Setoh K, Matsuda K, Nakano S, Goto A, Katagiri R, Yamaji T, Sawada N, Tsugane S, Wakai K, Yamamoto M, Sasaki M, Matsuda F, Okada Y, Iwasaki M, Brennan P, Matsuo K, The BioBank Japan, Proj

Science advances　10　(4)　eade2780　2024/01/26

DOI： 10.1126/sciadv.ade2780 　

More details Close

An East Asian-specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G>A) is the major genetic determinant of alcohol consumption. We performed an rs671 genotype-stratified genome-wide association study meta-analysis of alcohol consumption in 175,672 Japanese individuals to explore gene-gene interactions with rs671 behind drinking behavior. The analysis identified three genome-wide significant loci (GCKR, KLB, and ADH1B) in wild-type homozygotes and six (GCKR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, and GOT2) in heterozygotes, with five showing genome-wide significant interaction with rs671. Genetic correlation analyses revealed ancestry-specific genetic architecture in heterozygotes. Of the discovered loci, four (GCKR, ADH1B, ALDH1A1, and ALDH2) were suggested to interact with rs671 in the risk of esophageal cancer, a representative alcohol-related disease. Our results identify the genotype-specific genetic architecture of alcohol consumption and reveal its potential impact on alcohol-related disease risk.
75歳居宅高齢者における口腔乾燥を起こす薬剤服薬と口腔健康状態の関連 LIFE study

石丸美穂, 大野幸子, 佐藤美寿々, 竹内研時, 玉田雄大, 村田典子, 前田恵, 相田潤, 福田治久

Journal of Epidemiology　34　(Suppl.)　180-180　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
歯周疾患に対するレセプトデータ病名・処置の妥当性の検証 LIFE Study

大野幸子, 石丸美穂, 佐藤美寿々, 井田有亮, 竹内研時, 玉田雄大, 大野洋介, 村田典子, 前田恵, 福田治久

Journal of Epidemiology　34　(Suppl.)　180-180　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Present state and perceived future use of teledentistry in long-term care facilities in Japan: A cross-sectional study. International-journal

Takuma Okumura, Kazuharu Nakagawa, Kanako Yoshimi, Mitsuko Saito, Kayoko Ito, Masataka Itoda, Kenji Takeuchi, Shinsuke Mizutani, Mitsuyoshi Yoshida, Yutaka Watanabe, Haruka Tohara

Digital health　10　20552076241282394-20552076241282394　2024

DOI： 10.1177/20552076241282394 　

More details Close

OBJECTIVES: Teledentistry could be effective in managing oral health through the provision of oral hygiene instruction and diagnostic services. This study aimed to assess the perception and usefulness of teledentistry in Japanese long-term care facilities. METHODS: We conducted a questionnaire survey to compare related factors of the usefulness of teledentistry and identify issues in its implementation. We chose 1000 facilities using a stratified random sampling method. The questionnaires were sent to the facilities in August 2021 and collected in December of the same year. Responses to the questionnaire items regarding the usefulness of teledentistry for oral management were divided into three groups according to the answer: perceiving teledentistry as "useful," "not useful," or "neither," including facilities that do not currently use teledentistry. RESULTS: In total, 26.1% (261) responded to the questionnaire, and among these, 184 facilities answered the question regarding the usefulness of teledentistry. Only two of these facilities implemented teledentistry. Facilities with dental hygienists (p = 0.040) and those that receive insured medical treatment: reimbursement for oral feeding maintenance II (p = 0.040) tended to perceive teledentistry as useful in the management of patients with coronavirus disease. The higher the number of services that responded to the question "what kind of services do you think can be provided via teledentistry?" the higher the percentage of "useful" responses. CONCLUSIONS: Although only a few facilities use teledentistry, many long-term care facilities perceive it as useful even without using it. The presence of dental hygienists and interprofessional work done with reimbursement for oral feeding maintenance II contributed to the perception of the usefulness of teledentistry in long-term care facilities.
75歳居宅高齢者における口腔乾燥を起こす薬剤服薬と口腔健康状態の関連 LIFE study

石丸美穂, 大野幸子, 佐藤美寿々, 竹内研時, 玉田雄大, 村田典子, 前田恵, 相田潤, 福田治久

Journal of Epidemiology　34　(Suppl.)　180-180　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
歯周疾患に対するレセプトデータ病名・処置の妥当性の検証 LIFE Study

大野幸子, 石丸美穂, 佐藤美寿々, 井田有亮, 竹内研時, 玉田雄大, 大野洋介, 村田典子, 前田恵, 福田治久

Journal of Epidemiology　34　(Suppl.)　180-180　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Changes in the utilization of outpatient and visiting dental care and per-attendance care cost by age groups during COVID-19 pandemic waves in Japan: A time-series analysis from LIFE study

Taro Kusama, Yudai Tamada, Megumi Maeda, Fumiko Murata, Ken Osaka, Haruhisa Fukuda, Kenji Takeuchi

Journal of Epidemiology　2024

DOI： 10.2188/jea.JE20230323 　
Poor oral health and dementia risk under time‐varying confounding: A cohort study based on marginal structural models

Taro Kusama, Kenji Takeuchi, Sakura Kiuchi, Jun Aida, Ken Osaka

Journal of the American Geriatrics Society　2023/12/08

DOI： 10.1111/jgs.18707 　
Does online communication mitigate the association between a decrease in face-to-face communication and laughter during the COVID-19 pandemic? A cross-sectional study from JACSIS study. International-journal

Sakura Kiuchi, Kenji Takeuchi, Taro Kusama, Upul Cooray, Yudai Tamada, Ken Osaka, Takahiro Tabuchi

Preventive medicine reports　36　102432-102432　2023/12

DOI： 10.1016/j.pmedr.2023.102432 　

More details Close

Laughter has a protective effect on human health. The spread of coronavirus disease 2019 (COVID-19) has changed opportunities for face-to-face communication and might decrease opportunities for laughter. This cross-sectional study aimed to investigate whether the decrease in face-to-face communication during the COVID-19 pandemic is associated with a decrease in laughter. Additionally, we investigated whether an increase in online communication mitigates this association. Data from the "Japan COVID-19 and Society Internet Survey (JACSIS)," conducted between August and September 2020, were used. Participants aged 15-79 years were included in this study. The outcome was a decrease in laughter before the onset of the COVID-19 pandemic. The explanatory variables were decreased face-to-face communication with friends and increased online communication (text message, telephone, and video contact). Causal mediation analysis was used to calculate prevalence ratios (PRs) and 95 % confidence intervals (CIs) of the controlled direct effects of increased online communication. Furthermore, the proportions eliminated (PEs) by an increase in online communication were calculated. Among the 25,482 participants, 40.4 % had decreased face-to-face communication and 21.4 % had a decreased frequency of laughter. After adjusting for confounders, a decrease in face-to-face communication was significantly associated with a decrease in laughter (PR = 1.62, 95 %CI = 1.55-1.70). PEs for decrease in laughter were 27.2 % (95 %CI = -2.0 to 56.4) for text-based communication, 36.1 % (95 %CI = 12.3-59.8) for telephone-based communication, and 28.6 % (95 %CI = 0.6-56.6) for video-based communication. Although a decrease in face-to-face communication was associated with a decrease in laughter during the COVID-19 pandemic, online communication, particularly telephone-based communication, mitigated this association.
Oral Hypofunction and Risk of Weight Change among Independent Older Adults. International-journal

Chihiro Shiota, Taro Kusama, Kenji Takeuchi, Sakura Kiuchi, Ken Osaka

Nutrients　15　(20)　2023/10/15

DOI： 10.3390/nu15204370 　

More details Close

Oral health is essential for nutritional status; however, little is known about its association with weight change. This study aimed to investigate whether the risk of weight change differs according to the presence of each important component of oral hypofunction (fewer remaining teeth, low chewing efficiency, swallowing problems, and xerostomia) among independent older adults. This was a three-year follow-up cohort study based on self-reported questionnaires. The participants were independent older adults aged ≥65 from the Japan Gerontological Evaluation Study (JAGES). We used >5% weight loss/gain during follow-up as the outcome variables, and the number of remaining teeth (≥20/10-19/0-9), the presence of chewing difficulty, swallowing problems, and xerostomia (yes/no) as the exposure variables. We fitted the Poisson regression model, including possible confounders to estimate the risk ratios (RRs) and 95% confidence intervals (CIs). For weight loss, RRs were significantly higher among those with 0-9 remaining teeth (RR = 1.17; 95% CI = 1.11-1.23), chewing difficulty (RR = 1.12; 95% CI = 1.07-1.16), and xerostomia (RR = 1.11; 95% CI = 1.06-1.16), but there was no significant association with swallowing problems (RR = 1.01; 95% CI = 0.97-1.06). For weight gain, we also found similar associations with oral hypofunction. Oral hypofunction among older adults could have non-negligible health impacts on nutritional status.
Reduced number of teeth with and without dental prostheses and low frequency of laughter in older adults: Mediation by poor oral function.

Yudai Tamada, Kenji Takeuchi, Taro Kusama, Masashige Saito, Tetsuya Ohira, Kokoro Shirai, Chikae Yamaguchi, Katsunori Kondo, Jun Aida, Ken Osaka

Journal of prosthodontic research　2023/10/05

DOI： 10.2186/jpr.JPR_D_23_00071 　

More details Close

PURPOSE: Laughter is expected to have health-protective effects, but the potential link between tooth loss and laughter remains unclear. Therefore, this study aimed to examine the association between tooth loss and a low frequency of laughter among older adults in Japan, to elucidate whether this association could be mitigated by dental prostheses, and to evaluate the magnitude of the association mediated by poor oral function. METHODS: We used cross-sectional data from 157,708 functionally independent participants aged ≥65 years (46.3% male) from the Japan Gerontological Evaluation Study. A modified Poisson regression model was applied to examine the association between the number of remaining teeth (≥20/10-19/0-9), dental prostheses use, and infrequent laughter (i.e., laughing never or almost never). Causal mediation analysis was performed to assess whether the association was mediated by difficulties in eating hard foods, choking, or dry mouth. RESULTS: Among the participants, 9,129 reported infrequent laughter. Participants with ≤9 and 10-19 teeth who did not use dental prostheses had a 1.29 and 1.14 times higher likelihood of infrequent laughter than those with ≥20 teeth, respectively. Furthermore, difficulty eating hard foods, choking, and dry mouth mediated 22.8%, 0.4%, and 4.3% of the association between fewer remaining teeth and infrequent laughter, respectively. Meanwhile, we did not find evidence for the differences in infrequent laughter between participants with ≤19 teeth using dental prostheses and those with ≥20 teeth. CONCLUSIONS: Tooth loss among individuals without dental prostheses was associated with infrequent laughter, and this association was mediated by poor oral function.
Association between dietary pattern and insomnia symptoms among independent older adults: A cross-sectional study based on JAGES. International-journal

Anna Kinugawa, Taro Kusama, Kenji Takeuchi, Jun Aida, Sakura Kiuchi, Ryoko Katagiri, Hiroyuki Hikichi, Satoshi Sasaki, Katsunori Kondo, Ken Osaka

Sleep medicine　112　70-76　2023/10/02

DOI： 10.1016/j.sleep.2023.09.027 　

More details Close

BACKGROUND: Poor diet can cause sleep disorders; however, this association has not been established in older populations. This study investigated the association between dietary patterns and insomnia symptoms in independent older adults. METHODS: This cross-sectional study targeted independent older Japanese adults aged ≥74 years. We used insomnia symptoms classified into three domains: difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), and insomnia. These symptoms were assessed as dependent variables by a self-reported questionnaire. Dietary patterns (DP), identified by principal component analysis of a self-administered diet history questionnaire, were used as independent variables. Poisson regression analysis was used to estimate the prevalence ratios and 95% confidence intervals with adjustment for potential confounders. RESULTS: Among 1,311 participants (mean age = 80.1; women, 48.5%), we identified three dietary patterns: DP1 was characterized by a high intake of vegetables, soy products, and fruits and a low intake of rice; DP2 was characterized by a high intake of fish, chicken, processed meat, and noodles and a low intake of soy products; and DP3 was characterized by a lower intake of fruits and confectionaries. Higher DP1 scores were significantly associated with a lower prevalence of DIS (p-for-trend = 0.012). A higher DP2 score was significantly associated with a higher prevalence of insomnia (p-for-trend = 0.032). There was no significant association between DP3 and insomnia symptoms (p-for-trend >0.05). CONCLUSION: Our results highlighted that a dietary pattern with a high intake of vegetables, soy products, and fruits may contribute to reducing insomnia symptoms among independent older adults.
Exploring the relationship between oral health and multiple health conditions: An outcome-wide approach.

Shiho Kino, Yudai Tamada, Kenji Takeuchi, Atsushi Nakagomi, Koichiro Shiba, Taro Kusama, Takafumi Yamamoto, Jun Aida

Journal of prosthodontic research　2023/08/11

DOI： 10.2186/jpr.JPR_D_23_00091 　

More details Close

PURPOSE: A growing body of evidence suggests that oral health is associated with a wide range of health outcomes; however, opinions tend to vary because of inconsistent findings. This study aimed to simultaneously examine the association between oral health status and multiple health and well-being indicators using outcome-wide epidemiology. METHODS: Data were obtained from the Japan Gerontological Evaluation Study. Oral health status was categorized as: ≥20 teeth, 10-19 teeth with dental prosthesis, 0-9 teeth with prosthesis, 10-19 teeth without prosthesis, and 0-9 teeth without prosthesis. We examined the associations between oral health status in 2013 and 35 health and well-being outcomes in 2019, including physical/cognitive health, psychological distress, subjective health, social well-being, prosocial/altruistic behaviors, and health behaviors, using two databases (n=32,827 and 15,905). RESULTS: Compared to individuals with ≥20 teeth, those with <20 teeth had a 10-33% higher risk of mortality and a 7-10% higher risk of functional disability six years later. Additionally, individuals with fewer than 20 teeth tended to go out less frequently and eat fewer vegetables and fruits. Furthermore, individuals with 0-9 teeth without a prosthesis were more likely to have severe functional disability (risk ratio (RR):1.17, 95% confidence interval (CI):1.05-1.31), engage in fewer intellectual activities (standardized difference: 0.17, 95% CI: 0.10-0.24), and feel more hopeless (RR: 1.21, 95% CI: 1.04-1.41). CONCLUSIONS: The prevention of tooth loss and prosthodontic treatment may be associated with reduced mortality and functional disability, as well as maintenance of intellectual ability, frequency of going out, and improvements in dietary lifestyle.
GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese - the J-MICC Study.

Mineko Tsukamoto, Asahi Hishida, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Yasufumi Kato, Nobuyuki Hamajima, Yuichiro Nishida, Chisato Shimanoe, Rie Ibusuki, Kenichi Shibuya, Naoyuki Takashima, Yasuyuki Nakamura, Miho Kusakabe, Yohko Nakamura, Yuriko N Koyanagi, Isao Oze, Takeshi Nishiyama, Sadao Suzuki, Isao Watanabe, Daisuke Matsui, Jun Otonari, Hiroaki Ikezaki, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai, Keitaro Matsuo

Journal of epidemiology　2023/07/29

DOI： 10.2188/jea.JE20220341 　

More details Close

BACKGROUND: The present genome-wide association study (GWAS) aimed to reveal the genetic loci associated with folate metabolites as well as to detect related gene-environment interactions in Japanese. METHODS: We conducted the GWAS of plasma homocysteine (Hcy), folic acid (FA), and vitamin B12 (VB12) levels in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study participants who joined from 2005 to 2012, and also estimated gene-environment interactions. In the replication phase, we used data from the Yakumo Study conducted in 2009. In the discovery phase, data of 2,263 participants from four independent study sites of the J-MICC Study were analyzed. In the replication phase, data of 573 participants from the Yakumo Study were analyzed. RESULTS: For Hcy, MTHFR locus on chr 1, NOX4 on chr 11, CHMP1A on chr 16, and DPEP1 on chr 16 reached genome-wide significance (P < 5×10-8). MTHFR also associated with FA, and FUT2 on chr 19 associated with VB12. We investigated gene-environment interactions in both studies and found significant interactions between MTHFR C677T and ever drinking, current drinking, and physical activity > 33% on Hcy (β = 0.039, 0.038 and -0.054, P = 0.018, 0.021 and < 0.001, respectively) and the interaction of MTHFR C677T with ever drinking on FA (β = 0.033, P = 0.048). CONCLUSIONS: The present GWAS revealed the folate metabolism-associated genetic loci and gene-environment interactions with drinking and physical activity in Japanese, suggesting the possibility of future personalized CVD prevention.
Compliance Trajectory and Patterns of COVID-19 Preventive Measures, Japan, 2020-2022. International-journal

Taro Kusama, Kenji Takeuchi, Yudai Tamada, Sakura Kiuchi, Ken Osaka, Takahiro Tabuchi

Emerging infectious diseases　29　(9)　2023/07/24

DOI： 10.3201/eid2909.221754 　

More details Close

COVID-19 remains a global health threat. Compliance with nonpharmaceutical interventions is essential because of limited effectiveness of COVID-19 vaccines, emergence of highly contagious variants, and declining COVID-19 antibody titers over time. We evaluated compliance with 14 nonpharmaceutical intervention-related COVID-19 preventive behaviors, including mask wearing, ventilation, and surface sanitation, in a longitudinal study in Japan using 4 waves of Internet survey data obtained during 2020-2022. Compliance with most preventive behaviors increased or remained stable during the 2-year period, except for surface sanitation and going out behaviors; compliance with ventilation behavior substantially decreased in winter. Compliance patterns identified from latent class analysis showed that the number of persons in the low compliance class decreased, whereas those in the personal hygiene class increased. Our findings reflect the relaxation of mobility restriction policy in Japan, where the COVID-19 pandemic continues. Policymakers should consider behavioral changes caused by new policies to improve COVID-19 prevention strategies.
Effectiveness of COVID-19 vaccines against infection in Japan: A test-negative study from the VENUS study. International-journal

Yudai Tamada, Kenji Takeuchi, Taro Kusama, Megumi Maeda, Fumiko Murata, Ken Osaka, Haruhisa Fukuda

Vaccine　2023/07/22

DOI： 10.1016/j.vaccine.2023.07.035 　

More details Close

BACKGROUND: Although the effectiveness of coronavirus disease 2019 (COVID-19) vaccines is a crucial public health concern, evidence from Western Pacific countries is limited, including Japan. This study aimed to estimate the COVID-19 vaccines effectiveness (VE) against infection during the Delta variant predominance (July-September 2021) in Japan. METHODS: We performed a test-negative study using COVID-19 test data of ≥20-year-old residents in four municipalities who were tested in medical institutions between July 1 and September 30, 2021. We extracted COVID-19 test data from healthcare claims data, and the vaccination status at the testing date was ascertained using the Vaccination Record System data. Confirmed positive cases were identified using data from the national system for COVID-19, Health Center Real-time Information-sharing System on COVID-19. Logistic regression analyses were conducted to estimate the odds of testing positive according to vaccination status. VE was calculated as (1 - odds ratio) × 100%. RESULTS: This study included 530 positive and 15,650 negative results. Adjusted manufacturer-unspecified VE was 4.1% (95% confidence interval [CI], -36.5-32.6) at 0-13 days after the first dose, 45.2% (95% CI, 13.4-65.3) at ≥14 days after the first dose, 85.2% (95% CI, 69.9-92.7) at 0-13 days after the second dose, and 79.6% (95% CI, 72.6-84.8) at ≥14 days after the second dose. In addition, the VE after the second dose was highest at 14-34 days after the dose (VE, 89.1%; 95% CI, 80.5-93.9). CONCLUSIONS: High real-world effectiveness of COVID-19 vaccines, especially two doses, against infection during the Delta variant predominance in Japan was confirmed.
Oral self-care, pneumococcal vaccination, and pneumonia among Japanese older people, assessed with machine learning. International-journal

Yuko Inoue, Upul Cooray, Miho Ishimaru, Kousuke Saito, Kenji Takeuchi, Katsunori Kondo, Jun Aida

The journals of gerontology. Series A, Biological sciences and medical sciences　2023/07/10

DOI： 10.1093/gerona/glad161 　

More details Close

BACKGROUND: Pneumonia is a leading cause of death worldwide. It is a particularly serious burden in older people, as they tend to have a weakened immune response. Identifying the role of oral self-care and pneumococcal vaccination in healthy, independent older people can aid pneumonia prevention among them. This study investigated the associations between oral self-care, pneumococcal vaccination, and pneumonia experience among independent older people. METHODS: This cross-sectional study used data from the 2016 Japan Gerontological Evaluation Study (JAGES). We used machine learning to examine the association between oral self-care and the experience of pneumonia over the previous year, stratified by pneumococcal vaccination. The covariates were sex, age, years of education, equivalent annual income, medical history of stroke, oral health status (choking, dryness, number of teeth), and smoking status. The analysis included 17,217 independent older people aged 65 and over. RESULTS: The prevalence of pneumonia experienced among those who brushed their teeth once or less per day was 4.5% and 5.3% for those with and those without pneumococcal vaccinations, respectively. In the unvaccinated group, the odds ratio of pneumonia experience for those who brushed their teeth once or less a day was 1.57 (95% CI 1.15-2.14) compared to those who brushed their teeth three or more times a day. By contrast, there was no significant association between the frequency of toothbrushing and the experience of pneumonia among people who received pneumococcal vaccination. CONCLUSION: Oral care influenced the experience of pneumonia among independent older people who did not receive pneumococcal vaccination.
Association of daily physical activity and leisure-time exercise with dysphagia risk in community-dwelling older adults: a cross-sectional study. International-journal

Tomoko Maehara, Rumi Nishimura, Akari Yoshitake, Mineko Tsukamoto, Yuka Kadomatsu, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Kenji Wakai, Mariko Naito

Scientific reports　13　(1)　10893-10893　2023/07/05

DOI： 10.1038/s41598-023-37605-z 　

More details Close

This study aimed to clarify the association of daily physical activity and leisure-time exercise with the risk of dysphagia in community-dwelling Japanese older adults using a questionnaire-based survey. We analyzed 3070 participants (1657 men, 1413 women; age 66 ± 4 years [mean ± SD]) of the Shizuoka and Daiko studies within the Japanese Multi-Institutional Collaborative Cohort study. We used the Dysphagia Risk Assessment for the Community-dwelling Elderly questionnaire to assess dysphagia risk and the International Physical Activity Questionnaire to assess daily physical activity and leisure-time exercise. Logistic regression analyses were used to evaluate the independent association of the amount of physical activity and leisure-time exercise with dysphagia risk. The proportion of participants with dysphagia risk was 27.5% (n = 844) and the risk was significantly higher in women (29.8%, n = 421) than in men (25.5%, n = 423; P = 0.008). Daily physical activity was not associated with dysphagia risk. A greater amount of leisure-time exercise was associated with lower dysphagia risk (P for trend = 0.003) and individuals in the highest leisure-time exercise quartile had a significantly lower odds ratio (0.68, 95% CI 0.52-0.89) than those in the lowest quartile, even after adjusting for the covariates.
Dental prosthesis use is associated with higher protein intake among older adults with tooth loss. International-journal

Taro Kusama, Kenji Takeuchi, Sakura Kiuchi, Jun Aida, Hiroyuki Hikichi, Satoshi Sasaki, Katsunori Kondo, Ken Osaka

Journal of oral rehabilitation　2023/07/02

DOI： 10.1111/joor.13554 　

More details Close

BACKGROUND: Tooth loss is associated with reduced protein intake, which leads to sarcopenia and frailty in older adults. OBJECTIVE: To evaluate the protective effect of dental prostheses on decreased protein intake in older adults with tooth loss. METHODS: This cross-sectional study was based on a self-reported questionnaire targeting older adults. Data were obtained from the Iwanuma Survey of the Japan Gerontological Evaluation Study. We used % energy intake (%E) of total protein as the outcome and the use of dental prostheses and number of remaining teeth as explanatory variables. We estimated the controlled direct effects of tooth loss by fixing the use/non-use of dental prostheses based on a causal mediation analysis, including possible confounders. RESULTS: Among 2095 participants, the mean age was 81.1 years (1SD = 5.1), and 43.9% were men. The average protein intake was 17.4%E (1SD = 3.4) of the total energy intake. Among participants with ≥20, 10-19 and 0-9 remaining teeth, the average protein intake was 17.7%E, 17.2%E/17.4%E and 17.0%E/15.4%E (with/without a dental prosthesis), respectively. Compared to participants with ≥20 remaining teeth, those with 10-19 remaining teeth without a dental prosthesis did not have a significantly different total protein intake (p > .05). Among those with 0-9 remaining teeth without a dental prosthesis, total protein intake was significantly low (-2.31%, p < .001); however, the use of dental prostheses mitigated the association by 79.4% (p < .001). CONCLUSION: Our results suggest that prosthodontic treatment could contribute to maintaining protein intake in older adults with severe tooth loss.
Exposure to household dysfunction at childhood and later number of teeth among older Japanese adults: A life course study from the Japan Gerontological Evaluation Study. International-journal

Hazem Abbas, Kenji Takeuchi, Sakura Kiuchi, Katsunori Kondo, Ken Osaka

Journal of public health dentistry　83　(3)　299-308　2023/07

DOI： 10.1111/jphd.12582 　

More details Close

OBJECTIVES: The aim of this retrospective cohort study was to investigate the life course association between exposure to two household dysfunctions (father violence against mother and parental divorce) at childhood (≤18 years) with later number of remaining teeth (≥65 years) in functionally independent older Japanese population. This was the first study to investigate this research question in the Asian context. METHODS: The Japan Gerontological Evaluation study (JAGES) self-reported retrospective data gathered in 2013 was used (n = 21,604). Each household dysfunction was binary variable (Yes/No), while the five categories of the number of remaining teeth were ≥20, 10-19, 5-9, 1-4, and no teeth. Sex-stratified ordered logistic regression models were used to calculate the odds ratios (OR) of having fewer teeth. The models were adjusted for age, economic adversity in childhood, educational attainment, comorbidities, and smoking status. RESULTS: Overall, 46.4% were men and a total of 1149 participants (5.3%) experienced household dysfunction at childhood [men = 642 (6.4%), women = 507 (4.4%)]. The regression models showed higher OR of having fewer teeth among men who experienced a household dysfunction [OR = 1.16; 95% Confidence interval (CI) = 1.00-1.36] than men who did not. This association was not observed among women [OR = 0.94; 95% CI = 0.79-1.13]. Similar magnitude and direction of the association was observed among men but not among women when the two components of household dysfunction were used separately and aggregately as exposure variables. CONCLUSION: An exposure to a household dysfunction at childhood was associated with having fewer teeth in later life among men but not among women.
高齢者における緑茶摂取と主観的な口腔健康状態との関連横断研究より

野口有紀, 藤田美枝子, 種村崇, 竹内研時, 吉田直樹

東海公衆衛生雑誌　11　(1)　65-70　2023/07
Publisher: 東海公衆衛生学会
ISSN： 2187-736X

eISSN： 2434-0421
The role of science communication and academic health advocacy in improving population oral health and tackling inequalities. International-journal

Hazem Abbas, Kenji Takeuchi, Ken Osaka, Carol C Guarnizo-Herreño, Georgios Tsakos, Richard G Watt

Community dentistry and oral epidemiology　2023/06/06

DOI： 10.1111/cdoe.12882 　

More details Close

Oral conditions are a public health problem globally and stark oral health inequalities exist between and within countries. Yet, oral diseases are rarely considered as a health priority and evidence-informed policy generation is challenging. Science communication and health advocacy are critical in that respect. However, due to time limitations, research workload and other factors, academics are usually hindered from participating in such lengthy endeavours. Here, we make the case that 'science communication and health advocacy task forces' should be a priority at academic institutions. The two main duties of these task forces are knowledge transfer about the burden of oral conditions and patterns of inequalities, and their underlying social and commercial determinants, and advocacy and mediation between the stakeholders involved directly or indirectly in policy making. These interdisciplinary task forces, including both academics and non-academics, should collectively have skills that include (1) knowledge about oral health, dental public health and epidemiology, (2) ability to communicate clearly and coherently and make the case in both lay and scientific language terms, (3) familiarity with digital and social media platforms and ability to create visual aids, videos and documentaries, (4) good negotiation skills and (5) maintaining scientific transparency and avoiding getting involved in confrontation with political parties. In the current context, the role of the academic institutions should not only be the production of knowledge, but also the active transferability and application of this knowledge towards public benefit.
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. International-journal

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Bao Song, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Karen M Funderburk, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Batel Blechter, Bryan A Bassig, Jin Hee Kim, Demetrius Albanes, Jason Y Y Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, Dean H Hosgood, Hideo Kunitoh, Harsh Patel, Shun-Ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G Schwartz, Richard Houlston, Margaret R Spitz, Ivan P Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, Bu-Tian Ji, H-Erich Wichmann, David C Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K Field, Sanjay S Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C H Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K C Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L Stevens, Joseph F Fraumeni Jr, Nilanjan Chatterjee, Olga Y Gorlova, Chao Agnes Hsiung, Christopher I Amos, Hongbing Shen, Stephen J Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan

Nature communications　14　(1)　3043-3043　2023/05/26

DOI： 10.1038/s41467-023-38196-z 　

More details Close

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.
Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation. International-journal

Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N Koyanagi, Masahiro Nakatochi, Yoichi Sutoh, Shiori Nakano, Isao Oze, Hidemi Ito, Taiki Yamaji, Norie Sawada, Masao Iwagami, Aya Kadota, Teruhide Koyama, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Keitaro Tanaka, Toshiro Takezaki, Issei Imoto, Midori Suzuki, Yukihide Momozawa, Kenji Takeuchi, Akira Narita, Atsushi Hozawa, Kengo Kinoshita, Atsushi Shimizu, Kozo Tanno, Keitaro Matsuo, Shoichiro Tsugane, Kenji Wakai, Makoto Sasaki, Masayuki Yamamoto, Motoki Iwasaki

Scientific reports　13　(1)　7052-7052　2023/04/29

DOI： 10.1038/s41598-023-33966-7 　

More details Close

Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and colorectal cancer risk. In the single nucleotide polymorphism (SNP)-exposure analysis, we meta-analysed study-level genome-wide associations of fasting glucose (~ 17,289 individuals), HbA1c (~ 52,802 individuals), and fasting C-peptide (1,666 individuals) levels from the Japanese Consortium of Genetic Epidemiology studies. The odds ratios of colorectal cancer were 1.01 (95% confidence interval [CI], 0.99-1.04, P = 0.34) for fasting glucose (per 1 mg/dL increment), 1.02 (95% CI, 0.60-1.73, P = 0.95) for HbA1c (per 1% increment), and 1.47 (95% CI, 0.97-2.24, P = 0.06) for fasting C-peptide (per 1 log increment). Sensitivity analyses, including Mendelian randomisation-Egger and weighted-median approaches, revealed no significant association between glycaemic characteristics and colorectal cancer (P > 0.20). In this study, genetically predicted glycaemic characteristics were not significantly related to colorectal cancer risk. The potential association between insulin resistance and colorectal cancer should be validated in further studies.
Lower socio-economic status in adolescence is associated with poor oral health at an older age: Mediation by social and behavioural factors. International-journal

Kinumi Yamamoto-Kuramoto, Taro Kusama, Sakura Kiuchi, Katsunori Kondo, Ken Osaka, Kenji Takeuchi, Jun Aida

Gerodontology　2023/04/10

DOI： 10.1111/ger.12688 　

More details Close

AIM: To examine the mediators between lower socio-economic status (SES) in adolescence and oral health at an older age to uncover the underlying mechanisms of the association. METHODS: Participants (n = 21 536) aged ≥65 years from the Japan Gerontological Evaluation Study were evaluated. The dependent variables were self-rated chewing difficulty and having ≤19 remaining teeth. The main independent variable was self-perceived SES in adolescence. The Karlson-Holm-Breen method was used for mediation analysis. RESULTS: Mean age of the participants was 74.8 years (standard deviation = 6.4), and 51.5% were female. Overall, 5598 (26.0%) participants reported chewing difficulty and 9404 (43.7%) had ≤19 remaining teeth. Lower SES in adolescence was associated with a higher prevalence of chewing difficulty (odds ratio [OR] = 1.38, 95%confidence interval [CI] = 1.29-1.48; total effect). After controlling for mediators, OR for lower SES in adolescence was 1.22 (95%CI = 1.13-1.30; direct effect) and 1.13 (95%CI = 1.11-1.16; indirect effect). Mediators, prominently the number of teeth and income, explained 39.3% of the associations. Lower SES in adolescence increased the odds of ≤19 remaining teeth by OR = 1.23 (95% CI = 1.16-1.31; total effect). After controlling for mediators, the OR for lower SES in adolescence was 1.03 (95%CI = 0.97-1.10; direct effect) and 1.19 (95%CI = 1.16-1.23; indirect effect). Mediators, prominently educational attainment, explained 85.0% of the associations. CONCLUSIONS: Lower SES in adolescence was associated with poor oral health at an older age through mediators. Approaches that consider social determinants from the beginning of the life course are required.
高齢者におけるインターネット利用と現在歯との関連

野口有紀, 藤田美枝子, 上田一紀, 種村崇, 竹内研時, 吉田直樹

口腔衛生学会雑誌　73　(増刊)　163-163　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯科受診の有無と8年間の累積介護費用との関連 JAGESコホート研究

木内桜, 竹内研時, 草間太郎, 中澤典子, 相田潤, 小坂健, 近藤克則, 斉藤雅茂

口腔衛生学会雑誌　73　(増刊)　142-142　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
労働者におけるVisual Display Terminals時間と歯痛との関連 JACSIS研究

村松賢志郎, 塩田千尋, 竹内研時, 草間太郎, 木内桜, 中澤典子, 小坂健

口腔衛生学会雑誌　73　(増刊)　165-165　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
良好な職場環境と予防目的の歯科受診との関連 JACSIS研究

劉芳吟, 竹内研時, 草間太郎, 木内桜, 中澤典子, 塩田千尋, 小坂健

口腔衛生学会雑誌　73　(増刊)　166-166　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
新型コロナウイルス流行下における帰宅時のうがい習慣と味覚・嗅覚障害との関連の検討 JASTIS研究

大内博貴, 中澤典子, 竹内研時, 草間太郎, 木内桜, 塩田千尋, 小坂健

口腔衛生学会雑誌　73　(増刊)　173-173　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
高齢者の日常生活における笑いの頻度と抑うつ状態の関連 JAGES縦断研究

岡崎愛, 竹内研時, 草間太郎, 木内桜, 小坂健

口腔衛生学会雑誌　73　(増刊)　176-176　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
ストロング系アルコール飲料の摂取習慣と歯周病との関連 JACSIS研究

佐藤那紀, 竹内研時, 草間太郎, 木内桜, 中澤典子, 塩田千尋, 小坂健

口腔衛生学会雑誌　73　(増刊)　182-182　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
Association Between Toothbrushing Habits and COVID-19 Symptoms

Hazem Abbas, Kenji Takeuchi, Shihoko Koyama, Ken Osaka, Takahiro Tabuchi

International Dental Journal　73　(2)　302-310　2023/04

DOI： 10.1016/j.identj.2022.07.011 　

ISSN： 0020-6539

eISSN： 1875-595X
Association Between Toothbrushing Habits and COVID-19 Symptoms. International-journal

Hazem Abbas, Kenji Takeuchi, Shihoko Koyama, Ken Osaka, Takahiro Tabuchi

International dental journal　73　(2)　302-310　2023/04

DOI： 10.1016/j.identj.2022.07.011 　

More details Close

OBJECTIVES: The association between toothbrushing and coronavirus disease 2019 (COVID-19) infections is unknown. The aim of this study was to test the hypothesis that the change in time and frequency of toothbrushing is associated with having COVID-19 symptoms. METHODS: In this 8-month retrospective cohort study, we used the data from the Japan COVID-19 and Society Internet Survey (JACSIS; N = 22,366), which was conducted between August and September 2020. The logistic regression analyses were used to calculate the odds ratios (ORs) of having the 3 main COVID-19 symptoms (high fever, cough, and taste and smell disorder). Confounders were age, sex, educational attainment, equivalised income level, self-rated health, health literacy, and living area. RESULTS: The mean age of the participants was 49 years (SD = ±17.3), and 49.2% were male. Overall 2704 (12.1%) participants changed (increased or decreased) the time and frequency of toothbrushing, whilst 19,662 (87.9%) did not change. Only 60 participants (0.3%) had the 3 main COVID-19 symptoms. All logistic regression models showed that those who had a change in time and frequency of toothbrushing had higher odds of having the 3 main COVID-19 symptoms compared to those who had unchanged time and frequency of toothbrushing. The ORs ranged from 6.00 (95% confidence interval [CI], 3.60-9.99) in the crude model to 4.08 (95% CI, 2.38-6.98) in the fully adjusted model. CONCLUSIONS: The change in time and frequency of toothbrushing from before to after the COVID-19 pandemic was associated with having the 3 main COVID-19 symptoms.
質問紙で調査した成人の身体活動：日本多施設共同コーホート研究（J-MICC Study）

齋藤義信, 小熊祐子, 中村翔, 成松宏人, 中嶋綾子, 池崎裕昭, 田中恵太郎, 原めぐみ, 玉田雄大, 永吉真子, 田村高志, 菱田朝陽, 尾瀬功, 谷山祐香里, 三上春夫, 永瀬浩喜, 嶽﨑俊郎, 指宿りえ, 鈴木貞夫, 大谷隆浩, 小山晃英, 渡邉功, 栗木清典, 喜多義邦, 高嶋直敬, 有澤孝吉, 釜野桜子, 竹内研時, 若井建志, J-MICC研究グループ

運動疫学研究　2023/03/31

DOI： 10.24804/ree.2154 　
Oral status and incident functional disability: A 9-year prospective cohort study from the JAGES. International-journal

Kinumi Yamamoto-Kuramoto, Sakura Kiuchi, Kenji Takeuchi, Taro Kusama, Noriko Nakazawa, Yudai Tamada, Jun Aida, Katsunori Kondo, Ken Osaka

Archives of gerontology and geriatrics　111　105009-105009　2023/03/28

DOI： 10.1016/j.archger.2023.105009 　

More details Close

INTRODUCTION: The population-attributable risk of oral status for incident functional disability remains unknown. We investigated the impact of a range of oral statuses (number of remaining teeth, chewing difficulty, dry mouth, and choking) on incident functional disability. METHODS: Participants (n = 44,083) aged ≥ 65 years from the Japan Gerontological Evaluation Study were evaluated. The outcome variable was incident functional disability, and the explanatory variables were four select oral statuses. The possible confounders were included as covariates. Using the Cox proportional hazards model, we calculated hazard ratios (HRs), 95% confidence intervals (CIs), and their population-attributable fractions (PAFs). RESULTS: The mean age of the participants was 73.7 (standard deviation=6.0) years at baseline, and 53.2% were women. A total of 8,091 participants (18.4%) developed functional disabilities during the follow-up period. Among the four oral statuses, the incidence rate of functional disability was the highest in those with chewing difficulty (3.27/100 person-years), followed by those with dry mouth (3.20/100 person-years), choking (3.10/100 person-years), and ≤19 remaining teeth (2.89/100 person-years). After adjusting for all covariates, chewing difficulty showed the highest risk of functional disability (HR=1.22, 95%CI=1.16-1.28), followed by ≤19 remaining teeth (HR=1.18, 95%CI=1.12-1.25), dry mouth (HR=1.18, 95%CI=1.12-1.24), and choking (HR=1.10, 95%CI=1.04-1.17). Regarding PAF, ≤19 remaining teeth (12.0%) were the largest, followed by chewing difficulty (7.2%), dry mouth (4.6%), and choking (1.9%). CONCLUSIONS: Maintaining a good oral status may reduce the risk of functional disability later in life. Given its population contribution, tooth loss had the largest impact among the four oral conditions.
Frequency of going outdoors and risk of poor oral health among older Japanese adults: a longitudinal cohort from the Japan Gerontological Evaluation Study.

Keiko Ishimura, Ryoto Sakaniwa, Kokoro Shirai, Jun Aida, Kenji Takeuchi, Katsunori Kondo, Hiroyasu Iso

Journal of epidemiology　2023/03/25

DOI： 10.2188/jea.JE20220221 　

More details Close

BackgroundThe association between the frequency of going outdoors and the risk of poor oral health has been reported in several studies; however, the findings have been inconclusive.MethodsWe conducted a three-year longitudinal study of 19,972 Japanese adults aged ≥65 years who reported no poor oral condition at baseline in 2013. The respondents rated their frequency of going outdoors in three categories (≤1, 2-3, or ≥4 times/week), and the oral conditions reported in 2016 included tooth loss, chewing difficulty, swallowing difficulty, dry mouth, and composite outcomes. The associations between the frequency of going outdoors and the risk of poor oral health were examined as relative risk ratios (RR) and 95% confidence intervals (CI) using multivariable Poisson regression, while mediation analysis was performed to investigate indirect effects.ResultsDuring the follow-up, 32.5% of participants developed poor oral health. In the mediation analysis, indirect effects were observed through low instrumental activities of daily living, depressive symptoms, little social network diversity, and underweight.Compared to going outdoors ≥4 times/week, the multivariable RR(95%CI) of composite poor oral health conditions was 1.12 (1.05-1.20) for 2-3 times/week and 1.22 (1.07-1.39) for ≤1 time/week (P-trend<0.001). Similar associations were observed for tooth loss, chewing difficulty, and swallowing difficulty; the corresponding RRs(95%CIs) were 1.07(0.97-1.19) and 1.36(1.13-1.64) (P-trend=0.002), 1.18(1.06-1.32) and 1.30(1.05-1.60) (P-trend<0.001), and 1.15(1.01-1.31) and 1.38(1.08-1.77) (P-trend=0.002), respectively.ConclusionThe frequency of going outdoors was inversely associated with the risk of poor oral health through several modifiable risk factors in the older population.
自立高齢者における口腔の健康状態と体重減少の関連 JAGESコホート研究

塩田千尋, 草間太郎, 竹内研時, 木内桜, 近藤克則, 小坂健

Journal of Epidemiology　33　(Suppl.1)　115-115　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
高齢者における口腔機能と要介護発生との関連 JAGESコホート研究

山元絹美, 竹内研時, 木内桜, 草間太郎, 中澤典子, 玉田雄大, 近藤克則, 小坂健

Journal of Epidemiology　33　(Suppl.1)　156-156　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
高齢者における口腔の健康と健康状態・ウェルビーイングとの関連アウトカムワイド縦断研究

木野志保, 玉田雄大, 竹内研時, 中込敦士, 芝孝一郎, 草間太郎, 山本貴文, 相田潤

Journal of Epidemiology　33　(Suppl.1)　157-157　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Effects of gene–lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis International-journal

Sho Nakamura, Xuemin Fang, Yoshinobu Saito, Hiroto Narimatsu, Azusa Ota, Hiroaki Ikezaki, Chisato Shimanoe, Keitaro Tanaka, Yoko Kubo, Mineko Tsukamoto, Takashi Tamura, Asahi Hishida, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Toshiro Takezaki, Daisaku Nishimoto, Sadao Suzuki, Takahiro Otani, Nagato Kuriyama, Daisuke Matsui, Kiyonori Kuriki, Aya Kadota, Yasuyuki Nakamura, Kokichi Arisawa, Sakurako Katsuura-Kamano, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai

PLoS ONE　18　(2 February)　e0279169　2023/02

DOI： 10.1371/journal.pone.0279169 　

eISSN： 1932-6203
BMI and cardiometabolic traits in Japanese: a Mendelian randomization study.

Mako Nagayoshi, Asahi Hishida, Tomonori Shimizu, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Isao Oze, Yuriko N Koyanagi, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Sakurako Katsuura-Kamano, Kokichi Arisawa, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai

Journal of epidemiology　2023/01/28

DOI： 10.2188/jea.JE20220154 　

More details Close

BACKGROUND: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. METHODS: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study, and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses by the two-stage least squares estimator method. The β-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses. RESULTS: In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with higher risks of higher blood pressure, triglycerides, uric acid, lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent by different methods, including the directions. CONCLUSIONS: The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes.
Co-Payments and Inequality in Gingival Bleeding and Dental Visits. International-journal

Noriko Nakazawa, Taro Kusama, Kenji Takeuchi, Sakura Kiuchi, Tatsuo Yamamoto, Katsunori Kondo, Ken Osaka, Jun Aida

International dental journal　2023/01/13

DOI： 10.1016/j.identj.2022.11.009 　

More details Close

OBJECTIVES: Japan's universal health insurance covers a wide range of dental treatments, and the co-payment rates differ by age. We investigated whether the inequality in gingival bleeding and dental visits was smaller amongst those with lower co-payment rates. METHODS: This cross-sectional study used data from the 2019 Japan Gerontological Evaluation Study. The participants were functionally independent adults aged 65 years or older. The dependent variables were current gingival bleeding as a symptom of periodontal diseases and dental nonattendance for treatment in the past year. The independent variables were ridit scores of equivalent income and educational status. For covariates, we used age, sex, and the number of remaining teeth. To evaluate the inequalities, we used the slope index of inequality (SII) and the relative index of inequality (RII). We also conducted stratified analyses by co-payment rates (30%, 20%, and 10%) to clarify the difference in inequalities by co-payment rate. RESULTS: A total of 15,389 participants were included in the analysis; their mean age was 71.8 (SD = 4.1) and 51.8% were women. There were significant absolute and relative inequalities in gingival bleeding and dental visits by equivalent income and education. With regards to educational status, inequalities were lower with a decrease in the co-payment rate. In particular, relative inequality by education in gingival bleeding was the largest amongst the 30% co-payment group (RII, 1.918; 95% confidence interval [CI], 1.386 to 2.656). For gingival bleeding, the absolute and relative inequality by equivalent income were not significant amongst the 10% co-payment group (SII, -0.003; 95% CI, -0.003 to 0.028; RII, 1.006; 95% CI = 0.676 to 1.498). CONCLUSIONS: A low co-payment rate was associated with smaller inequalities in gingival bleeding and dental visits by equivalent income and educational status.
Association of second-hand smoke exposure, quantified by salivary cotinine, with dental caries in Japanese adolescents.

Naohiro Takao, Michiko Furuta, Toru Takeshita, Shinya Kageyama, Takuro Goto, Myrna N Zakaria, Kenji Takeuchi, Yoshihisa Yamashita

Journal of oral science　65　(2)　107-110　2023

DOI： 10.2334/josnusd.22-0388 　

More details Close

PURPOSE: Second-hand smoke has adverse effects on oral health. This cohort study used a multilevel approach to investigate the association of second-hand smoke exposure, as determined by salivary cotinine level, with dental caries in adolescents. METHODS: Data from 75 adolescents aged 11 or 12 years and 2,061 teeth without dental caries were analyzed in this study. Annual dental examinations to assess dental caries were conducted between 2018 and 2021. Salivary cotinine and Dentocult SM-Strip level were measured at baseline. Information on the smoking habits of parents, snack frequency, regular dental visits, and use of fluoride toothpaste was collected at baseline from parent-reported questionnaires. RESULTS: During the 3-year follow-up, dental caries was noted in 21 adolescents and 43 teeth. Participants exposed to parental smoking had higher salivary cotinine levels than those whose parents did not smoke. The multilevel Cox regression model showed that a high salivary cotinine level was associated with the incidence of dental caries, after adjusting for potential confounding factors (hazard ratio, 3.39; 95% confidence interval 1.08-10.69). CONCLUSION: This study suggests that the risk of dental caries is higher for adolescents who have high salivary cotinine levels attributable to second-hand smoke exposure.
Association between periodontal pocket depth determined during dental check-ups and new onset of diabetes in community residents: the LIFE study Peer-reviewed

70　(1)　39-47　2023/01

DOI： 10.11236/jph.22-038 　

ISSN： 0546-1766 2187-8986
Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis. International-journal

Sho Nakamura, Xuemin Fang, Yoshinobu Saito, Hiroto Narimatsu, Azusa Ota, Hiroaki Ikezaki, Chisato Shimanoe, Keitaro Tanaka, Yoko Kubo, Mineko Tsukamoto, Takashi Tamura, Asahi Hishida, Isao Oze, Yuriko N Koyanagi, Yohko Nakamura, Miho Kusakabe, Toshiro Takezaki, Daisaku Nishimoto, Sadao Suzuki, Takahiro Otani, Nagato Kuriyama, Daisuke Matsui, Kiyonori Kuriki, Aya Kadota, Yasuyuki Nakamura, Kokichi Arisawa, Sakurako Katsuura-Kamano, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai

PloS one　18　(2)　e0279169　2023

DOI： 10.1371/journal.pone.0279169 　

More details Close

BACKGROUND: The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene-environment interactions, has been attracting attention in recent years. However, evidence for gene-environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene-lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. METHODS: This study aimed to elucidate the effects of gene-lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model. RESULTS: The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg/m2 and -0.07 (0.16), respectively. The correlation between GRS and BMI was r(12,916) = 0.13 (95% confidence interval [CI] 0.11-0.15, P < 0.001). An interaction between GRS and saturated fatty acid intake was observed (β = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and n-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (β = -0.12, 95% CI -0.22 to -0.03). CONCLUSION: Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene-lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.
URAT1遺伝子の機能低下型変異による痛風の保護効果は、ABCG2遺伝子の機能低下型変異による痛風のリスク亢進効果を上回る

豊田優, 河村優輔, 中山昌喜, 東野俊英, 清水聖子, 大山博司, 市田公美, 四ノ宮成祥, 高田龍平, 松尾洋孝, 中岡博史, 竹内研時, 井ノ上逸郎, 鈴木洋史

痛風と尿酸・核酸　46　(2)　149-149　2022/12
Publisher: (一社)日本痛風・尿酸核酸学会
eISSN： 2435-0095
URAT1遺伝子の機能低下型変異による痛風の保護効果は、ABCG2遺伝子の機能低下型変異による痛風のリスク亢進効果を上回る

豊田優, 河村優輔, 中山昌喜, 東野俊英, 清水聖子, 大山博司, 市田公美, 四ノ宮成祥, 高田龍平, 松尾洋孝, 中岡博史, 竹内研時, 井ノ上逸郎, 鈴木洋史

痛風と尿酸・核酸　46　(2)　149-149　2022/12
Publisher: (一社)日本痛風・尿酸核酸学会
eISSN： 2435-0095
Free Sugar Intake and Periodontal Diseases: A Systematic Review. International-journal

Taro Kusama, Noriko Nakazawa, Kenji Takeuchi, Sakura Kiuchi, Ken Osaka

Nutrients　14　(21)　2022/10/22

DOI： 10.3390/nu14214444 　

More details Close

High free sugar intake is associated with an increased risk of various non-communicable diseases. We aimed to systematically review articles investigating the association between free sugar intake and periodontal diseases. This systematic review was conducted according to PRISMA guidelines and was registered in the PROSPERO database (CRD42022337828). We obtained articles from PubMed, Web of Science, and Scopus in April 2022. The study selection was performed according to predefined eligibility criteria based on the following PECOS: (P) general population, (E/C) free-sugar-containing food/beverage intake, (O) clinically measured periodontal diseases, and (S) observational study and clinical trial. Of the 839 screened records, 13 studies were included in the review. Most studies (n = 12) had a cross-sectional design. The age groups in the included studies were children/adolescents (n = 5) and adults (n = 8). Among the included studies, 11 reported a significant association between the frequent intake of free-sugar-containing food or beverages and a higher prevalence or incidence of periodontal diseases. The quality of most of the included studies was scored "fair" based on the Newcastle-Ottawa Quality Assessment Scale. Although the majority of the included studies reported a significant positive association between high free sugar intake and periodontal diseases, the evidence is considered to be limited due to the study designs.
Irregular sleep and all-cause mortality: A large prospective cohort study. International-journal

Chie Omichi, Teruhide Koyama, Hiroshi Kadotani, Etsuko Ozaki, Satomi Tomida, Tamami Yoshida, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Keitaro Tanaka, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Isao Oze, Keitaro Matsuo, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Kenichi Shibuya, Sadao Suzuki, Miki Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kenji Takeuchi, Kenji Wakai

Sleep health　8　(6)　678-683　2022/10/10

DOI： 10.1016/j.sleh.2022.08.010 　

More details Close

OBJECTIVES: Previous studies using objective parameters have shown that irregular sleep is associated with the disease incidence, progression, or mortality. This study aimed to determine the association between subjective sleep duration and sleep regularity, with mortality in a large population. METHODS: Participants were from the Japan Multi-Institutional Collaborative Cohort study. We obtained information from each participant on sleep duration, sleep regularity, and demographics and overall lifestyle using self-administered questionnaires. We defined sleep regularity according to participants' subjective assessment of sleep/wake time regularity. Participants (n = 81,382, mean age: 58.1 ± 9.1years, males: 44.2%) were classified into 6 groups according to sleep duration and sleep regularity. Hazard ratios (HR) for time-to-event of death were calculated using the Cox proportional hazards model. RESULTS: The mean follow-up period was 9.1 years and the mean sleep duration was 6.6 h/day. Irregular sleep significantly increased the risk of all-cause mortality in all models compared with regular sleep (HR 1.30, 95% confidence interval; CI, 1.18-1.44), regardless of sleep duration. Multivariable analysis of the 6 groups by sleep pattern (sleep regularity and duration) showed irregular sleep and sleep durations of <6 h/day, 6 to <8 h/day, or ≥8 h/day were associated with a 1.2-1.5-fold increases in mortality, compared to regular sleep and sleep duration of 6 to <8 h/day. CONCLUSIONS: Our study shows an association between sleep irregularity and all-cause mortality in a large Japanese population. Our findings provide further confirmation of the need to consider not only sleep duration, but also the regularity aspect of sleep schedules.
Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study. International-journal

Kosuke Saita, Masahiko Sumitani, Daisuke Nishizawa, Takashi Tamura, Kazutaka Ikeda, Kenji Wakai, Yoshika Sudo, Hiroaki Abe, Jun Otonari, Hiroaki Ikezaki, Kenji Takeuchi, Asahi Hishida, Keitaro Tanaka, Chisato Shimanoe, Toshiro Takezaki, Rie Ibusuki, Isao Oze, Hidemi Ito, Etsuko Ozaki, Daisuke Matsui, Yohko Nakamura, Miho Kusakabe, Sadao Suzuki, Hiroko Nakagawa-Senda, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kiyonori Kuriki, Yoshikuni Kita, Yasuyuki Nakamura, Yukihide Momozawa, Kanji Uchida

Medicine　101　(37)　e30580　2022/09/16

DOI： 10.1097/MD.0000000000030580 　

More details Close

Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)-located on the gene encoding for pleiotrophin on chromosome 7-that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing.
中学生の歯間部清掃用具使用と養育者の歯科保健行動の関連

藤田美枝子, 野口有紀, 吉田直樹, 竹内研時

社会歯科学会雑誌　15　(1)　14-27　2022/09
Publisher: 社会歯科学会
ISSN： 2434-2084
高齢者における歯科補綴装置の使用が抑うつ発症リスクへもたらす効果 JAGES縦断研究

中澤典子, 竹内研時, 草間太郎, 木内桜, 近藤克則, 小坂健

日本公衆衛生学会総会抄録集　81回　229-229　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高齢者の喫煙状況と健康・Well-beingとの関連 Out-come-wide縦断研究

玉田雄大, 草間太郎, 竹内研時, 木内桜, 小坂健, 近藤克則, 田淵貴大

日本公衆衛生学会総会抄録集　81回　318-318　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
SARS-CoV-2流行下における日本の一般住民の予防行動の遵守割合の推移

塩田千尋, 玉田雄大, 竹内研時, 草間太郎, 木内桜, 小坂健, 田淵貴大

日本公衆衛生学会総会抄録集　81回　458-458　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Blood lipids and the risk of colorectal cancer: Mendelian randomization analyses in the Japanese Consortium of Genetic Epidemiology studies. International-journal

Masao Iwagami, Atsushi Goto, Ryoko Katagiri, Yoichi Sutoh, Yuriko N Koyanagi, Masahiro Nakatochi, Shiori Nakano, Akiko Hanyuda, Akira Narita, Atsushi Shimizu, Kozo Tanno, Atsushi Hozawa, Kengo Kinoshita, Isao Oze, Hidemi Ito, Taiki Yamaji, Norie Sawada, Yohko Nakamura, Sho Nakamura, Kiyonori Kuriki, Sadao Suzuki, Asahi Hishida, Yumiko Kasugai, Issei Imoto, Midori Suzuki, Yukihide Momozawa, Kenji Takeuchi, Masayuki Yamamoto, Makoto Sasaki, Keitaro Matsuo, Shoichiro Tsugane, Kenji Wakai, Motoki Iwasaki

Cancer prevention research (Philadelphia, Pa.)　15　(12)　827-836　2022/08/30

DOI： 10.1158/1940-6207.CAPR-22-0146 　

More details Close

The associations between blood lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, and low-density lipoprotein cholesterol (LDL-C), and colorectal cancer risk are controversial. We evaluated potential causal relationships between blood lipids and colorectal cancer risk. Using the baseline data from the Japanese Consortium of Genetic Epidemiology studies, we estimated the single-nucleotide polymorphism (SNP)-exposure associations (n=34,546 for TC, n=50,290 for HDL-C, n=51,307 for triglycerides, and n=30,305 for LDL-C). We also estimated the SNP-outcome associations in another Japanese dataset (n=7,936 colorectal cancer cases and n=38,042 controls). We conducted Mendelian randomization analyses for the association between each blood lipid type and the risk of colorectal cancer using an inverse variance-weighted method. The total variances explained by the selected SNPs in TC (68 SNPs), HDL-C (50 SNPs), log-transformed triglycerides (26 SNPs), and LDL-C (35 SNPs) were 7.0%, 10.0%, 6.2%, and 5.7%, respectively. The odds ratios for colorectal cancer were 1.15 (95% confidence interval 1.01-1.32) per 1 standard deviation (SD) (33.3 mg/dL) increase in TC, 1.11 (0.98-1.26) per 1 SD (15.4 mg/dL) increase in HDL-C, 1.06 (0.90-1.26) per 1 SD (0.5 log-mg/dL) increase in log-transformed triglycerides, and 1.17 (0.91-1.50) per 1 SD (29.6 mg/dL) increase in LDL-C. Sensitivity analyses consistently suggested the positive association between TC and colorectal cancer, whereas results of each lipid component were inconsistent. In conclusion, this large Mendelian randomization study of a Japanese population showed a potentially causal association between high TC and colorectal cancer risk, although the association between each lipid component and colorectal cancer remained inconclusive.
Burden of Oral Diseases and Access to Oral Care in an Ageing Society. International-journal

Jun Aida, Kenji Takeuchi, Michiko Furuta, Kanade Ito, Yuji Kabasawa, Georgios Tsakos

International dental journal　72　(4S)　S5-S11　2022/08

DOI： 10.1016/j.identj.2022.06.012 　

More details Close

OBJECTIVE: The total years lived with disability among older people, and the concomitant burden of tooth loss in ageing societies have increased. This study is an overview of the burden of oral diseases and access to oral care in an ageing society. METHODS: We selected key issues related to the burden of oral diseases and access to oral care and reviewed the relevant literature. RESULTS: The rising number of older people with teeth increases their oral health care needs. To improve access to oral care, affordability of care is a great concern with respect to universal health coverage. In addition, accessibility is a crucial issue, particularly for vulnerable older adults. To improve oral care access, attempts to integrate oral health care into general care are being made in ageing countries. For this purpose, provision of professional oral care at home through domiciliary visits and provision of daily oral health care by non-dental professional caregivers are important. Oral health care for older people reduces general diseases such as pneumonia and malnutrition, which in turn could reduce further healthcare costs. CONCLUSIONS: To address the growing burden of oral care in ageing societies, special provision of oral health care to vulnerable older people, and integration of oral care with primary care will be required.
Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population. International-journal

Ryosuke Fujii, Asahi Hishida, Masahiro Nakatochi, Yoshiki Tsuboi, Koji Suzuki, Takaaki Kondo, Hiroaki Ikezaki, Megumi Hara, Rieko Okada, Takashi Tamura, Ippei Shimoshikiryo, Sadao Suzuki, Teruhide Koyama, Kiyonori Kuriki, Naoyuki Takashima, Kokichi Arisawa, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai

Circulation. Genomic and precision medicine　15　(4)　101161CIRCGEN121003612　2022/06/06

DOI： 10.1161/CIRCGEN.121.003612 　

More details Close

BACKGROUND: Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wide PRS for blood pressure in a Japanese population and examined the associations between this PRS and hypertension prevalence. METHODS: We performed a cross-sectional study in 11 252 Japanese individuals who participated in the J-MICC (Japan Multi-Institutional Collaborative Cohort) study. Using publicly available GWAS summary statistics from Biobank Japan, we developed the PRS in the target data (n=7876). With >30 000 single nucleotide polymorphisms, we evaluated PRS performance in the test data (n=3376). Hypertension was defined as systolic blood pressure of 130 mm Hg or more, or diastolic blood pressure of 85 mm Hg or more, or taking an antihypertensive drug. RESULTS: Compared with the middle PRS quintile, the prevalence of hypertension at the top PRS quintile was higher independently from traditional risk factors (odds ratio, 1.73 [95% CI, 1.32-2.27]). The difference of mean systolic blood pressure and diastolic blood pressure between the middle and the top PRS quintile was 4.55 (95% CI, 2.26-6.85) and 2.32 (95% CI, 0.86-3.78) mm Hg, respectively. Subgroups reflecting combinations of Japanese PRS and modifiable lifestyles and factors (smoking, alcohol intake, sedentary time, and obesity) were associated with the prevalence of hypertension. A European-derived PRS was not associated with hypertension in our participants. CONCLUSIONS: A PRS for blood pressure was significantly associated with hypertension and BP traits in a general Japanese population. Our findings also highlighted the importance of a combination of PRS and risk factors for identifying high-risk subgroups.
Secondhand aerosol exposure from heated tobacco products and its socioeconomic inequalities in Japan: The JASTIS study 2017-2020. International-journal

Yudai Tamada, Kenji Takeuchi, Sumiyo Okawa, Takahiro Tabuchi

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco　24　(9)　1430-1438　2022/03/21

DOI： 10.1093/ntr/ntac074 　

More details Close

INTRODUCTION: The growing use of heated tobacco products (HTPs) has raised concerns about secondhand aerosol (SHA) from HTPs, but few studies have been reported on it. This study aimed to investigate the trends in SHA exposure and their socioeconomic inequalities in Japan. METHODS: The prevalence of SHA exposure from 2017 to 2020 was estimated using longitudinal internet survey data of 5,221 participants, aged 20-69 years in 2017 (baseline), with adjustments using inverse probability weighting for 'being a participant in an internet survey'. Multivariable modified Poisson regression models were applied to examine the association between socioeconomic status (i.e., educational attainment and equivalent income) at baseline and SHA exposure in 2020 with adjustments for sex and age. RESULTS: The estimated prevalence of SHA exposure has consistently increased from 4.5% in 2017 to 10.8% in 2020. Lower educational attainment was associated with a higher risk of SHA exposure (p for trend = 0.010). The covariate-adjusted risks of SHA exposure in participants with a low-education and middle-education level were 1.57 and 1.34 times higher, respectively, than in those with a high-education level. However, significant differences in risks of SHA exposure between participants with low-, middle-, and high-income levels were not observed. Meanwhile, participants with a low-education and middle-education level also had 1.87 and 1.61 times higher risks of SHS exposure than those with a high-education level, respectively. CONCLUSIONS: Our study revealed a rapid increase in SHA exposure and the existence of educational inequalities in both SHA and SHS exposure. IMPLICATIONS: Using longitudinal internet cohort survey data, we found that the prevalence of exposure to secondhand aerosol (SHA) from heated tobacco products (HTPs) rapidly increased to 10.8% in 2020 in Japan. Furthermore, people with lower educational attainment were at higher risk of SHA exposure, suggesting that extensive educational interventions may be necessary to inform the public that although emissions from HTPs contain significantly lesser amounts of harmful and potentially harmful constituents and these compounds than cigarette smoke, they are not harmless and still entail risks, and its long-term effects are unknown. Therefore, future extensive monitoring of SHA exposure is needed.
Occasions for laughter and dementia risk: Findings from a six-year cohort study.

Yu Wang, Kokoro Shirai, Tetsuya Ohira, Mayumi Hirosaki, Naoki Kondo, Kenji Takeuchi, Chikae Yamaguchi, Yudai Tamada, Katsunori Kondo, Dorina Cadar, Hiroyasu Iso

Geriatrics & gerontology international　22　(5)　392-398　2022/03/14

DOI： 10.1111/ggi.14371 　

ISSN： 1444-1586

eISSN： 1447-0594
Information Usage and Compliance with Preventive Behaviors for COVID-19: A Longitudinal Study with Data from the JACSIS 2020/JASTIS 2021. International-journal

Taro Kusama, Sakura Kiuchi, Kenji Takeuchi, Takaaki Ikeda, Noriko Nakazawa, Anna Kinugawa, Ken Osaka, Takahiro Tabuchi

Healthcare (Basel, Switzerland)　10　(3)　2022/03/13

DOI： 10.3390/healthcare10030521 　

eISSN： 2227-9032
12歳児とその養育者の主観的口腔健康状態に関連があるのか? 探索的研究より

野口有紀, 吉田直樹, 藤田美枝子, 竹内研時

社会歯科学会雑誌　14　(2)　2-12　2022/03
Publisher: 社会歯科学会
ISSN： 2434-2084
A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility.

Shun-Jen Chang, Yu Toyoda, Yusuke Kawamura, Takahiro Nakamura, Masahiro Nakatochi, Akiyoshi Nakayama, Wei-Ting Liao, Seiko Shimizu, Tappei Takada, Kenji Takeuchi, Kenji Wakai, Yongyong Shi, Nariyoshi Shinomiya, Chung-Jen Chen, Changgui Li, Yukinori Okada, Kimiyoshi Ichida, Hirotaka Matsuo

Human cell　35　(2)　767-770　2022/03

DOI： 10.1007/s13577-021-00665-2 　

ISSN： 0914-7470

eISSN： 1749-0774
Investigation of miRNA expression profiles using cohort samples reveals potential early detectability of colorectal cancers by serum miR-26a-5p before clinical diagnosis. International-journal

Asahi Hishida, Hiroya Yamada, Yoshitaka Ando, Yoshinaga Okugawa, Manabu Shiozawa, Yohei Miyagi, Yataro Daigo, Yuji Toiyama, Yumiko Shirai, Koji Tanaka, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Atsuyoshi Mori, Takaaki Kondo, Nobuyuki Hamajima, Kenji Takeuchi, Kenji Wakai

Oncology letters　23　(3)　87-87　2022/03

DOI： 10.3892/ol.2022.13207 　

ISSN： 1792-1074

eISSN： 1792-1082
A genome-wide association study on adherence to low-carbohydrate diets in Japanese. International-journal

Yasuyuki Nakamura, Takashi Tamura, Akira Narita, Atsushi Shimizu, Yoichi Sutoh, Naoyuki Takashima, Kenji Matsui, Naoko Miyagawa, Aya Kadota, Katsuyuki Miura, Jun Otonari, Hiroaki Ikezaki, Asahi Hishida, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Keitaro Tanaka, Chisato Shimanoe, Rie Ibusuki, Daisaku Nishimoto, Isao Oze, Hidemi Ito, Etsuko Ozaki, Daisuke Matsui, Haruo Mikami, Miho Kusakabe, Sadao Suzuki, Miki Watanabe, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kiyonori Kuriki, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai

European journal of clinical nutrition　76　(8)　1103-1110　2022/02/07

DOI： 10.1038/s41430-022-01090-w 　

ISSN： 0954-3007

eISSN： 1476-5640
Does laughing with others lower the risk of functional disability among older Japanese adults? The JAGES prospective cohort study. International-journal

Yudai Tamada, Chikae Yamaguchi, Masashige Saito, Tetsuya Ohira, Kokoro Shirai, Katsunori Kondo, Kenji Takeuchi

Preventive medicine　155　106945-106945　2022/02

DOI： 10.1016/j.ypmed.2021.106945 　

ISSN： 0091-7435

eISSN： 1096-0260
Yogurt product intake and reduction of tooth loss risk in a Japanese community. International-journal

Jiale Ma, Michiko Furuta, Kazuhiro Uchida, Toru Takeshita, Shinya Kageyama, Mikari Asakawa, Kenji Takeuchi, Shino Suma, Satoko Sakata, Jun Hata, Woosung Sohn, Toshiharu Ninomiya, Yoshihisa Yamashita

Journal of clinical periodontology　49　(4)　345-352　2022/01/23

DOI： 10.1111/jcpe.13593 　

ISSN： 0303-6979

eISSN： 1600-051X
The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study. International-journal

Mizuki Ohashi, Katsuyuki Miura, Naoyuki Takashima, Aya Kadota, Yoshino Saito, Shunichiro Tsuji, Takashi Murakami, Yuka Kadomatsu, Mako Nagayoshi, Megumi Hara, Keitaro Tanaka, Takashi Tamura, Asahi Hishida, Toshiro Takezaki, Ippei Shimoshikiryo, Etsuko Ozaki, Isao Watanabe, Sadao Suzuki, Miki Watanabe, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Sho Yamasaki, Hiroaki Ikezaki, Isao Oze, Yuriko N Koyanagi, Haruo Mikami, Yohko Nakamura, Kenji Takeuchi, Yoshikuni Kita, Kenji Wakai

Hypertension research : official journal of the Japanese Society of Hypertension　45　(4)　708-714　2022/01/14

DOI： 10.1038/s41440-021-00820-0 　

ISSN： 0916-9636

eISSN： 1348-4214
Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women. International-journal

Kayoko Koga, Megumi Hara, Chisato Shimanoe, Yuichiro Nishida, Takuma Furukawa, Chiharu Iwasaka, Keitaro Tanaka, Jun Otonari, Hiroaki Ikezaki, Yoko Kubo, Yasufumi Kato, Takashi Tamura, Asahi Hishida, Keitaro Matsuo, Hidemi Ito, Yohko Nakamura, Miho Kusakabe, Daisaku Nishimoto, Keiichi Shibuya, Sadao Suzuki, Miki Watanabe, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Kenji Wakai

Scientific reports　12　(1)　291-291　2022/01/07

DOI： 10.1038/s41598-021-04324-2 　

eISSN： 2045-2322
URAT1遺伝子の機能低下型変異による痛風の保護効果は、ABCG2遺伝子の機能低下型変異による痛風のリスク亢進効果を上回る

豊田優, 河村優輔, 中山昌喜, 東野俊英, 清水聖子, 大山博司, 市田公美, 四ノ宮成祥, 高田龍平, 松尾洋孝, 中岡博史, 竹内研時, 井ノ上逸郎, 鈴木洋史

日本痛風・尿酸核酸学会総会プログラム・抄録集　55回　69-69　2022/01
Publisher: (一社)日本痛風・尿酸核酸学会
尿酸輸送体遺伝子URAT1/SLC22A12の機能消失型変異の低尿酸血症への影響日本人4,993名の分子疫学的解析から

堀江美音, 中山昌喜, 河村優輔, 豊田優, 清水聖子, 川口真, 青木優佳, 藤原慎, 竹内研時, 今給黎敏彦, 岩澤聡子, 中島宏, 角田正史, 伊藤敬一, 熊谷裕生, 市田公美, 四ノ宮成祥, 松尾洋孝

防衛衛生　69　(別冊)　34-34　2022/01
Publisher: (一社)日本防衛衛生学会
ISSN： 0006-5528
Weight Loss Mediated the Relationship between Tooth Loss and Mortality Risk

T. Kusama, K. Takeuchi, S. Kiuchi, J. Aida, K. Kondo, K. Osaka

Journal of Dental Research　2022

DOI： 10.1177/00220345221120642 　

ISSN： 0022-0345

eISSN： 1544-0591
高齢者の日常生活における笑いとフレイル発生リスクとの関連 JAGES縦断研究

玉田雄大, 竹内研時, 斉藤雅茂, 山口知香枝, 白井こころ, 大平哲也, 小嶋雅代, 若井建志, 近藤克則

Journal of Epidemiology　32　(Suppl.1)　148-148　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Subjective cognitive complaints and dental clinic visits: A cross-sectional study from the Japan Gerontological Evaluation Study

Kinumi Yamamoto-Kuramoto, Sakura Kiuchi, Taro Kusama, Katsunori Kondo, Kenji Takeuchi, Ken Osaka, Jun Aida

Geriatrics and Gerontology International　2022

DOI： 10.1111/ggi.14455 　

ISSN： 1444-1586

eISSN： 1447-0594
Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. International-journal

Tien Van Nguyen, Kokichi Arisawa, Sakurako Katsuura-Kamano, Masashi Ishizu, Mako Nagayoshi, Rieko Okada, Asahi Hishida, Takashi Tamura, Megumi Hara, Keitaro Tanaka, Daisaku Nishimoto, Keiichi Shibuya, Teruhide Koyama, Isao Watanabe, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Yasuyuki Nakamura, Yoshino Saito, Hiroaki Ikezaki, Jun Otonari, Yuriko N Koyanagi, Keitaro Matsuo, Haruo Mikami, Miho Kusakabe, Kenji Takeuchi, Kenji Wakai

PloS one　17　(7)　e0269550　2022

DOI： 10.1371/journal.pone.0269550 　

More details Close

PURPOSE: The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. METHODS: We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35-69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. RESULTS: During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04-2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78-1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05). CONCLUSION: MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.
Effect of the interaction between physical activity and estimated macronutrient intake on HbA1c: population-based cross-sectional and longitudinal studies. International-journal

Takuma Furukawa, Yuichiro Nishida, Megumi Hara, Chisato Shimanoe, Kayoko Koga, Chiharu Iwasaka, Yasuki Higaki, Keitaro Tanaka, Ryoko Nakashima, Hiroaki Ikezaki, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Yudai Tamada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Hiroko Nakagawa-Senda, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Yasuyuki Nakamura, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Kenji Wakai

BMJ open diabetes research & care　10　(1)　2022/01

DOI： 10.1136/bmjdrc-2021-002479 　

eISSN： 2052-4897
Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study. International-journal

Takashi Matsunaga, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Toshiro Takezaki, Ippei Shimoshikiryo, Sadao Suzuki, Hiroko Nakagawa, Naoyuki Takashima, Yoshino Saito, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Nagato Kuriyama, Daisuke Matsui, Haruo Mikami, Yohko Nakamura, Isao Oze, Hidemi Ito, Masayuki Murata, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Kenji Takeuchi, Kenji Wakai

PloS one　17　(1)　e0262252　2022

DOI： 10.1371/journal.pone.0262252 　

eISSN： 1932-6203
Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: Baseline data from the Japan Multi-Institutional Collaborative cohort study. International-journal

Sakurako Katsuura-Kamano, Kokichi Arisawa, Hirokazu Uemura, Tien Van Nguyen, Toshiro Takezaki, Rie Ibusuki, Sadao Suzuki, Takahiro Otani, Rieko Okada, Yoko Kubo, Takashi Tamura, Asahi Hishida, Teruhide Koyama, Daisuke Matsui, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Hiroaki Ikezaki, Yuji Matsumoto, Yuichiro Nishida, Chisato Shimanoe, Isao Oze, Keitaro Matsuo, Haruo Mikami, Miho Kusakabe, Kenji Takeuchi, Kenji Wakai

Preventive medicine reports　24　101613-101613　2021/12

DOI： 10.1016/j.pmedr.2021.101613 　

eISSN： 2211-3355
コロナ禍における歯磨き及び集団フッ化物洗口等の実施状況報告

田所大典, 相田潤, 草間太郎, 井下英二, 竹内研時, 濃野要, 松山祐輔, 三宅達郎, 小坂健

日本公衆衛生学会総会抄録集　80回　437-437　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study.

Megumi Hara, Yuichiro Nishida, Keitaro Tanaka, Chisato Shimanoe, Kayoko Koga, Takuma Furukawa, Yasuki Higaki, Koichi Shinchi, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Takashi Tamura, Asahi Hishida, Mineko Tsukamoto, Yuka Kadomatsu, Keitaro Matsuo, Isao Oze, Mikami Haruo, Kusakabe Miho, Toshiro Takezaki, Rie Ibusuki, Sadao Suzuki, Hiroko Nakagawa-Senda, Daisuke Matsui, Teruhide Koyama, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai

Journal of epidemiology　33　(6)　285-293　2021/10/16

DOI： 10.2188/jea.JE20210155 　

More details Close

BACKGROUND: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and CKD, whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function. METHODS: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR<60 mL/min/1.73 m2. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied. RESULTS: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (Pfor trend MVPA<0.0001) and lower eGFR (Pfor trend SB<0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA≥20 MET·h/day: 0.76 [95%CI: 0.68-0.85] compared to MVPA<5 MET·h/day) and a higher OR of CKD (adjusted OR of SB≥16 h/day: 1.81 [95%CI: 1.52-2.15] compared to SB<7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD. CONCLUSIONS: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.
Sex-specific Relationship between Stress Coping Strategies and All-Cause Mortality: Japan Multi-Institutional Collaborative Cohort Study.

Mako Nagayoshi, Kenji Takeuchi, Yudai Tamada, Kato Yasufumi, Yoko Kubo, Rieko Okada, Takashi Tamura, Asahi Hishida, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Yuriko N Koyanagi, Keitaro Matsuo, Mikami Haruo, Kusakabe Miho, Daisaku Nishimoto, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai

Journal of epidemiology　33　(5)　236-245　2021/09/25

DOI： 10.2188/jea.JE20210220 　

More details Close

BACKGROUND: Stress coping strategies are related to health outcomes. However, there is no clear evidence for sex differences between stress-coping strategies and mortality. We investigated the relationship between all-cause mortality and stress-coping strategies, focusing on sex differences among Japanese adults. METHODS: A total of 79,580 individuals aged 35-69 years participated in the Japan Multi-Institutional Collaborative Cohort Study between 2004 and 2014 and were followed up for mortality. The frequency of use of the five coping strategies was assessed using a questionnaire. Sex-specific, multivariable-adjusted hazard ratios (HRs) for using each coping strategy "sometimes," and "often/very often" (versus "very few" use) were computed for all-cause mortality. Furthermore, relationships were analyzed in specific follow-up periods when the proportion assumption was violated. RESULTS: During the follow-up (median: 8.5 years), 1,861 mortalities were recorded. In women, three coping strategies were related to lower total mortality. The HRs (95% confidence intervals) for "sometimes" were 0.81 (0.67-0.97) for emotional expression, 0.79 (0.66-0.95) for emotional support-seeking, and 0.80 (0.66-0.98) for disengagement. Men who "sometimes" used emotional expression and sometimes or often used problem-solving and positive reappraisal had a 15-41% lower HRs for all-cause mortality. However, those relationships were dependent on the follow-up period. There was evidence that sex modified the relationships between emotional support-seeking and all-cause mortality (p for interaction = 0.03). CONCLUSIONS: In a large Japanese population, selected coping strategies were associated with all-cause mortality. The relationship of emotional support-seeking was different between men and women.
Comparison of frailty associated factors between older adult patients with rheumatoid arthritis and community dwellers

Sae Ozeki, Kenji Takeuchi, Mikako Yasuoka, Koto Kamiji, Toshihisa Kojima, Yuko Waguri-Nagaya, Toshiyuki Ojima, Katsunori Kondo, Kenji Wakai, Masayo Kojima

Archives of Gerontology and Geriatrics　96　2021/09/01

DOI： 10.1016/j.archger.2021.104455 　

ISSN： 0167-4943

eISSN： 1872-6976
Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: estimates of population attributable risk in a Japanese community. International-journal

Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Yukie Shibata, Shino Suma, Shinya Kageyama, Mikari Asakawa, Yoshihiro Shimazaki, Jun Hata, Toshiharu Ninomiya, Yoshihisa Yamashita

Journal of periodontology　93　(4)　526-536　2021/08/26

DOI： 10.1002/JPER.21-0191 　

ISSN： 0022-3492
Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants.

Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, Ippei Shimoshikiryo, Daisaku Nishimoto, Keiichi Shimatani, Toshiro Takezaki, Hiroaki Ikezaki, Masayuki Murata, Megumi Hara, Yuichiro Nishida, Takashi Tamura, Asahi Hishida, Mako Nagayoshi, Rieko Okada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Takahiro Otani, Sadao Suzuki, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kokichi Arisawa, Sakurako Katsuura-Kamao, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai

Journal of epidemiology　33　(4)　193-200　2021/08/21

DOI： 10.2188/jea.JE20210142 　

More details Close

BACKGROUND: Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C. METHODS: Data from 11,498 men and women aged 35-69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (P < 5 × 10-8) were selected from the GWAS catalog, and seven representative SNPs were defined, and the population-based impact was estimated using population attributable fraction (PAF). RESULTS: We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex and the SNPs CETP rs3764261, APOA5 rs662799, LIPC rs1800588, LPL rs328, ABCA1 rs2575876, LIPG rs3786247, and APOE rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively. CONCLUSIONS: The present study showed that the population-based impact of genomic factor CETP rs3764261 for low HDL-C was higher than that of smoking and lower than that of drinking.
10-year trend of tooth loss and associated factors in a Japanese population-based longitudinal study. International-journal

Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Yukie Shibata, Shino Suma, Shinya Kageyama, Mikari Asakawa, Jun Hata, Daigo Yoshida, Yoshihiro Shimazaki, Toshiharu Ninomiya, Yoshihisa Yamashita

BMJ open　11　(8)　e048114　2021/08/18

DOI： 10.1136/bmjopen-2020-048114 　

eISSN： 2044-6055
A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals. International-journal

Yusuke Kawamura, Akiyoshi Nakayama, Seiko Shimizu, Yu Toyoda, Yuichiro Nishida, Asahi Hishida, Sakurako Katsuura-Kamano, Kenichi Shibuya, Takashi Tamura, Makoto Kawaguchi, Satoko Suzuki, Satoko Iwasawa, Hiroshi Nakashima, Rie Ibusuki, Hirokazu Uemura, Megumi Hara, Kenji Takeuchi, Tappei Takada, Masashi Tsunoda, Kokichi Arisawa, Toshiro Takezaki, Keitaro Tanaka, Kimiyoshi Ichida, Kenji Wakai, Nariyoshi Shinomiya, Hirotaka Matsuo

Biomedicines　9　(8)　2021/08/13

DOI： 10.3390/biomedicines9081012 　

eISSN： 2227-9059
Genetic-epidemiological analysis of hypouricemia from 4,993 Japanese on nonfunctional variants of URAT1/SLC22A12 gene. International-journal

Akiyoshi Nakayama, Yusuke Kawamura, Yu Toyoda, Seiko Shimizu, Makoto Kawaguchi, Yuka Aoki, Kenji Takeuchi, Rieko Okada, Yoko Kubo, Toshihiko Imakiire, Satoko Iwasawa, Hiroshi Nakashima, Masashi Tsunoda, Keiichi Ito, Hiroo Kumagai, Tappei Takada, Kimiyoshi Ichida, Nariyoshi Shinomiya, Hirotaka Matsuo

Rheumatology (Oxford, England)　61　(3)　1276-1281　2021/07/13

DOI： 10.1093/rheumatology/keab545 　

ISSN： 1462-0324

eISSN： 1462-0332
Effect of Underlying Cardiometabolic Diseases on the Association Between Sedentary Time and All-Cause Mortality in a Large Japanese Population: A Cohort Analysis Based on the J-MICC Study. International-journal

Teruhide Koyama, Etsuko Ozaki, Nagato Kuriyama, Satomi Tomida, Tamami Yoshida, Ritei Uehara, Keitaro Tanaka, Megumi Hara, Asahi Hishida, Rieko Okada, Yoko Kubo, Isao Oze, Yuriko N Koyanagi, Haruo Mikami, Yohko Nakamura, Ippei Shimoshikiryo, Toshiro Takezaki, Sadao Suzuki, Takahiro Otani, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Kenji Wakai

Journal of the American Heart Association　10　(13)　e018293　2021/07/06

DOI： 10.1161/JAHA.120.018293 　

More details Close

Background This study aimed to determine the association between sedentary time and mortality with regard to leisure-time physical activity with or without cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus. Methods and Results Using data from the J-MICC (Japan Multi-Institutional Collaborative Cohort) Study, 64 456 participants (29 022 men, 35 434 women) were analyzed. Hazard ratios (HRs) and 95% CIs were used to characterize the relative risk of all-cause mortality to evaluate its association with sedentary time (categorical variables: <5, 5 to <7, 7 to <9, ≥9 h/d and 2-hour increments in exposure) according to the self-reported hypertension, dyslipidemia, and diabetes mellitus using a Cox proportional hazards model. A total of 2257 participants died during 7.7 years of follow-up. The corresponding HRs for each 2-hour increment in sedentary time among participants with all factors, no factors, hypertension, dyslipidemia, and diabetes mellitus were 1.153 (95% CI, 1.114-1.194), 1.125 (95% CI, 1.074-1.179), 1.202 (95% CI, 1.129-1.279), 1.176 (95% CI, 1.087-1.273), and 1.272 (95% CI, 1.159-1.396), respectively. Furthermore, when analyzed according to the combined different factors (hypertension, dyslipidemia, and diabetes mellitus), HRs increased with each additional factor, and participants reporting all 3 conditions had the highest HR of 1.417 (95% CI, 1.162-1.728) independently of leisure-time metabolic equivalents. Conclusions The association between sedentary time and increased mortality is stronger among patients with hypertension, dyslipidemia, and diabetes mellitus regardless of leisure-time physical activity in a large Japanese population.
Dental Pain and Worsened Socioeconomic Conditions Due to the COVID-19 Pandemic. International-journal

Y Matsuyama, J Aida, K Takeuchi, S Koyama, T Tabuchi

Journal of dental research　100　(6)　591-598　2021/06

DOI： 10.1177/00220345211005782 　

More details Close

The coronavirus disease 2019 (COVID-19) pandemic has led to economic contraction and significant restrictions on society. The shock to the economy could lead to a deterioration of physical health outcomes, including dental health. The present study investigated the association between worsened socioeconomic conditions due to the COVID-19 pandemic and dental pain in Japan. The mediating effects of psychological distress and oral health-related behaviors were also evaluated. Cross-sectional data from the Japan COVID-19 and Society Internet Survey conducted from August to September 2020 (n = 25,482; age range, 15-79 y) were analyzed. Multivariable logistic regression models were fitted to evaluate the independent associations of household income reduction, work reduction, and job loss due to the COVID-19 pandemic with dental pain within a month. Dental pain was reported by 9.8%. Household income reduction, work reduction, and job loss were independently associated with dental pain after adjusting for confounders (odds ratios: 1.42 [95% confidence interval (CI), 1.28-1.57], 1.58 [95% CI, 1.41-1.76], 2.17 [95% CI, 1.64-2.88], respectively). The association related to household income reduction was mediated by psychological distress, postponing dental visits, toothbrushing behavior, and between-meals eating behavior by 21.3% (95% CI, 14.0-31.6), 12.4% (95% CI, 7.2-19.6), 1.5% (95% CI, -0.01 to 4.5), and 9.3% (95% CI, 5.4-15.2), respectively. Our findings showed that worsened socioeconomic conditions due to the COVID-19 pandemic deteriorated dental health. Policies that protect income and job loss may reduce dental health problems after the pandemic.
Number of teeth, denture wearing and cognitive function in relation to nutritional status in residents of nursing homes. International-journal

Shino Suma, Michiko Furuta, Kenji Takeuchi, Mikiko Tomioka, Yasuyuki Iwasa, Yoshihisa Yamashita

Gerodontology　39　(2)　197-203　2021/05/28

DOI： 10.1111/ger.12554 　

ISSN： 0734-0664

eISSN： 1741-2358
Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12. International-journal

Yu Toyoda, Yusuke Kawamura, Akiyoshi Nakayama, Hirofumi Nakaoka, Toshihide Higashino, Seiko Shimizu, Hiroshi Ooyama, Keito Morimoto, Naohiro Uchida, Ryuichiro Shigesawa, Kenji Takeuchi, Ituro Inoue, Kimiyoshi Ichida, Hiroshi Suzuki, Nariyoshi Shinomiya, Tappei Takada, Hirotaka Matsuo

Rheumatology (Oxford, England)　60　(11)　5224-5232　2021/04/02

DOI： 10.1093/rheumatology/keab327 　

More details Close

OBJECTIVES: Gout, caused by chronic elevation of serum uric acid levels, is the commonest form of inflammatory arthritis. The causative effect of common and rare variants of ATP-binding cassette transporter G2 (ABCG2/BCRP) on gout risk has been studied, but, little attention has been paid to the effect of common (rs121907892, p. W258X) and rare variants of urate transporter 1 (URAT1/SLC22A12) on gout, despite dysfunctional variants of URAT1 having been identified as pathophysiological causes of renal hypouricemia. METHODS: To address this important but overlooked issue, we investigated the effects of these URAT1 variants on gout susceptibility, using targeted exon sequencing on 480 clinically-defined gout cases and 480 controls of Japanese male in combination with a series of functional analyses of newly-identified URAT1 variants. RESULTS: Our results show that both common and rare dysfunctional variants of URAT1 markedly decrease the risk of gout (OR 0.0338, reciprocal OR 29.6, p = 7.66 × 1 0 -8). Interestingly, we also found that the URAT1-related protective effect on gout eclipsed the ABCG2-related causative effect (OR 2.30 - 3.32). Our findings reveal only one dysfunctional variant of URAT1 to have a substantial anti-gout effect, even in the presence of causative variants of ABCG2, a "gout gene". CONCLUSION: Our findings provide a better understanding of gout/hyperuricemia and its aetiology that is highly relevant to personalized health care. The substantial anti-gout effect of common and rare variants of URAT1 identified in the present study support the genetic concept of a 'Common Disease, Multiple Common and Rare Variant' model.
Airflow limitation and tongue microbiota in community-dwelling elderly individuals. International-journal

Toru Takeshita, Koichiro Matsumoto, Michiko Furuta, Satoru Fukuyama, Kenji Takeuchi, Hiroaki Ogata, Mikari Asakawa, Shinya Kageyama, Jun Hata, Toshiharu Ninomiya, Hiromasa Inoue, Yoshihisa Yamashita

ERJ open research　7　(2)　2021/04

DOI： 10.1183/23120541.00616-2020 　

More details Close

Numerous oral indigenous microorganisms are constantly introduced into the stomach via the laryngopharynx, and a portion of these microorganisms irregularly reaches the lower airways and lungs. This study investigated the association between airflow limitation and the status of tongue microbiota, which is a primary source of ingested oral bacterial populations. The study population consisted of 484 community-dwelling adults aged 70-80 years inhabiting Hisayama town, Japan, who underwent a regular health examination including dental examination and spirometry test in 2016. The bacterial density and composition of their tongue microbiota were determined using a previously used 16S rRNA gene to understand their relationship with oral health conditions. The present cross-sectional study compared the tongue microbiota status between elderly individuals with airflow limitation and those with normal airflow. The total bacterial density of the tongue microbiota of individuals with airflow limitation was significantly higher than that of individuals with normal airflow. Logistic regression analysis demonstrated that a high-biomass tongue microbiota was significantly associated with airflow limitation after adjustment for smoking intensity and other covariates (adjusted OR 1.61, 95% CI 1.01-2.60). Of the predominant commensals, higher amounts of Prevotella melaninogenica and Actinomyces odontolyticus were associated with a higher prevalence of airflow limitation. These results indicate that increased bacterial burden in the tongue microbiota is associated with a higher prevalence of airflow limitation.
Association of self-reported moderate vegetable juice intake with small decline in kidney function in a five-year prospective study. International-journal

Ryosuke Fujii, Takaaki Kondo, Mineko Tsukamoto, Sayo Kawai, Tae Sasakabe, Mariko Naito, Yoko Kubo, Rieko Okada, Takashi Tamura, Asahi Hishida, Jun Ueyama, Yumi Hayashi, Joji Ohnishi, Nobuyuki Hamajima, Kenji Takeuchi, Kenji Wakai

Nutrition (Burbank, Los Angeles County, Calif.)　84　111114-111114　2021/04

DOI： 10.1016/j.nut.2020.111114 　

More details Close

OBJECTIVES: Although consumption of vegetable and 100% fruit juices are an acceptable alternative for vegetable and fruit intake, information about their actual effects on kidney function is sparse. The aim of this study was to determine the association between the consumption of vegetable and fruit juices and changes in kidney function in a Japanese population over a 5-y period. METHODS: In this prospective study, we analyzed 2755 Japanese (742 men and 2013 women) individuals who participated in both the baseline and follow-up surveys in the Daiko study (a study within the Japan Multi-Institutional Collaborative Cohort study). Estimated glomerular filtration rate (eGFR) was calculated by age, sex, and serum creatinine level. For each beverage, we categorized all participants into four groups-rare (rarely consumed), low (≤2 cups/wk), moderate (3-4 cups/wk), or frequent (≥5 cups/wk) consumers of the beverage-based on a food frequency questionnaire. RESULTS: The mean baseline and follow-up eGFR (SD) were 82.4 (14.6) and 72.2 (12.6), respectively. In fully adjusted regression analyses, moderate consumption of vegetable juice was associated a lower decline in eGFR compared with the rare consumption group (β = -1.30; P = 0.01). Moreover, stratified analyses revealed that this significant association remained in those who were young, female, non-obese, normotensive, smoked cigarettes, consumed alcohol, or exercised. However, no significant association was found in analyses for fruit juices. CONCLUSIONS: This 5-y prospective study suggested an association between self-reported moderate consumption of vegetable juice and changes (possibly smaller decline) in kidney function in a relatively healthy Japanese population.
Body mass index and colorectal cancer risk: A Mendelian randomization study. International-journal

Shiori Suzuki, Atsushi Goto, Masahiro Nakatochi, Akira Narita, Taiki Yamaji, Norie Sawada, Ryoko Katagiri, Masao Iwagami, Akiko Hanyuda, Tsuyoshi Hachiya, Yoichi Sutoh, Isao Oze, Yuriko N Koyanagi, Yumiko Kasugai, Yukari Taniyama, Hidemi Ito, Hiroaki Ikezaki, Yuichiro Nishida, Takashi Tamura, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Kokichi Arisawa, Kenji Takeuchi, Kozo Tanno, Atsushi Shimizu, Gen Tamiya, Atsushi Hozawa, Kengo Kinoshita, Kenji Wakai, Makoto Sasaki, Masayuki Yamamoto, Keitaro Matsuo, Shoichiro Tsugane, Motoki Iwasaki

Cancer science　112　(4)　1579-1588　2021/04

DOI： 10.1111/cas.14824 　

More details Close

Traditional observational studies have reported a positive association between higher body mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other approaches to pursue the causal relationship between BMI and CRC is sparse. A two-sample Mendelian randomization (MR) study was undertaken using 68 single nucleotide polymorphisms (SNPs) from the Japanese genome-wide association study (GWAS) and 654 SNPs from the GWAS catalogue for BMI as sets of instrumental variables. For the analysis of SNP-BMI associations, we undertook a meta-analysis with 36 303 participants in the Japanese Consortium of Genetic Epidemiology studies (J-CGE), comprising normal populations. For the analysis of SNP-CRC associations, we utilized 7636 CRC cases and 37 141 controls from five studies in Japan, and undertook a meta-analysis. Mendelian randomization analysis of inverse-variance weighted method indicated that a one-unit (kg/m2 ) increase in genetically predicted BMI was associated with an odds ratio of 1.13 (95% confidence interval, 1.06-1.20; P value <.001) for CRC using the set of 68 SNPs, and an odds ratio of 1.07 (1.03-1.11, 0.001) for CRC using the set of 654 SNPs. Sensitivity analyses robustly showed increased odds ratios for CRC for every one-unit increase in genetically predicted BMI. Our MR analyses strongly support the evidence that higher BMI influences the risk of CRC. Although Asians are generally leaner than Europeans and North Americans, avoiding higher BMI seems to be important for the prevention of CRC in Asian populations.
Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study. Peer-reviewed

Madoka Iwase, Keitaro Matsuo, Masahiro Nakatochi, Isao Oze, Hidemi Ito, Yuriko Koyanagi, Tomotaka Ugai, Yumiko Kasugai, Asahi Hishida, Kenji Takeuchi, Rieko Okada, Yoko Kubo, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Toshiro Takezaki, Daisaku Nishimoto, Nagato Kuriyama, Etsuko Ozaki, Sadao Suzuki, Miki Watanabe, Haruo Mikami, Yohko Nakamura, Hirokazu Uemura, Sakurako Katsuura-Kamano, Kiyonori Kuriki, Yoshikuni Kita, Naoyuki Takashima, Masato Nagino, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai

Journal of epidemiology　31　(3)　172-179　2021/03/05

DOI： 10.2188/jea.JE20190296 　

More details Close

BACKGROUND: Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these have been focused on Europeans, and little evidence is available on the genetic effects across the life course of other ethnicities. METHODS: We conducted a cross-sectional study to examine the associations of 282 GWAS-identified single nucleotide polymorphisms with three BMI-related traits, current BMI, BMI at 20 years old (BMI at 20), and change in BMI (BMI change), among 11,586 Japanese individuals enrolled in the Japan Multi-Institutional Collaborative Cohort study. Associations were examined using multivariable linear regression models. RESULTS: We found a significant association (P < 0.05/282 = 1.77 × 10-4) between BMI and 11 polymorphisms in or near FTO, BDNF, TMEM18, HS6ST3, and BORCS7. The trend was similar between current BMI and BMI change, but differed from that of the BMI at 20. Among the significant variants, those on FTO were associated with all BMI traits, whereas those on TMEM18 and HS6SR3 were only associated with BMI at 20. The association of FTO loci with BMI remained, even after additional adjustment for dietary energy intake. CONCLUSIONS: Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways.
Association between periodontitis and fibrotic progression of non-alcoholic fatty liver among Japanese adults. International-journal

Kei Kuroe, Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Shino Suma, Takashi Shinagawa, Yoshihiro Shimazaki, Yoshihisa Yamashita

Journal of clinical periodontology　48　(3)　368-377　2021/03

DOI： 10.1111/jcpe.13415 　

More details Close

AIM: Non-alcoholic fatty liver (NAFL) is known to develop into liver fibrosis, which increases the risk of liver cirrhosis and liver cancer. The association between periodontal condition and fibrotic progression of NAFL is unclear. This study aimed to clarify this longitudinal association. MATERIALS AND METHODS: Among 4812 participants aged 35-64 years undergoing annual health check-ups between 2003 and 2004, and follow-up 5 years later, 392 participants were diagnosed with NAFL. After excluding participants with liver fibrosis at baseline, 341 participants were followed up for 5 years. NAFL disease fibrosis score of ≥-1.455 was used to evaluate the probability of the presence of liver fibrosis. RESULTS: During the follow-up period, 10.6% of participants progressed to liver fibrosis. A higher clinical attachment level (CAL) tended to be associated with the incidence of liver fibrosis in the logistic regression analysis (odds ratio [OR] 1.82, 95% confidence interval [CI], 0.94-3.49, p = .074). The stratified analysis by obesity revealed a significant association with higher CAL in obese participants (OR 2.87, 95% CI, 1.23-6.69, p = .015), but not in non-obese participants. CONCLUSION: Higher CAL was associated with an increased probability of liver fibrosis in obese adults with NAFL.
A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study. International-journal Peer-reviewed

Taro Suzuki, Yasuyuki Nakamura, Keitaro Matsuo, Isao Oze, Yukio Doi, Akira Narita, Atsushi Shimizu, Nahomi Imaeda, Chiho Goto, Kenji Matsui, Masahiro Nakatochi, Katsuyuki Miura, Naoyuki Takashima, Kiyonori Kuriki, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Rie Ibusuki, Toshiro Takezaki, Yuriko Koyanagi, Hidemi Ito, Daisuke Matsui, Teruhide Koyama, Haruo Mikami, Yohko Nakamura, Sadao Suzuki, Takeshi Nishiyama, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kenji Takeuchi, Takashi Tamura, Rieko Okada, Yoko Kubo, Yukihide Momozawa, Michiaki Kubo, Yoshikuni Kita, Kenji Wakai

European journal of clinical nutrition　75　(3)　480-488　2021/03

DOI： 10.1038/s41430-020-00702-7 　

More details Close

BACKGROUND/OBJECTIVE: Although benefits of fish consumption for health are well known, a significant percentage of individuals dislike eating fish. Fish consumption may be influenced by genetic factors in addition to environmental factors. We conducted a genome-wide association study (GWAS) to find genetic variations that affect fish consumption in a Japanese population. METHODS: We performed a two-stage GWAS on fish consumption using 13,739 discovery samples from the Japan Multi-Institutional Collaborative Cohort study, and 2845 replication samples from the other population. We used a semi-quantitative food frequency questionnaire to estimate food intake. Association of the imputed variants with fish consumption was analyzed by separate linear regression models per variant, with adjustments for age, sex, energy intake, principal component analysis components 1-10, and alcohol intake (g/day). We also performed conditional analysis. RESULTS: We found 27 single nucleotide polymorphisms (SNPs) located in 12q24 and 14q32.12 that were associated with fish consumption. The 19 SNPs were located at 11 genes including six lead SNPs at the BRAP, ACAD10, ALDH2, NAA25, and HECTD4 regions on 12q24.12-13, and CCDC197 region on 14q32.12. In replication samples, all five SNPs located on chromosome 12 were replicated successfully, but the one on chromosome 14 was not. Conditional analyses revealed that the five lead variants in chromosome 12 were in fact the same signal. CONCLUSION: We found that new SNPs in the 12q24 locus were related to fish intake in two Japanese populations. The associations between SNPs on chromosome 12 and fish intake were strongly confounded by drinking status.
A genome-wide association study on confection consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort Study. International-journal

Taro Suzuki, Yasuyuki Nakamura, Yukio Doi, Akira Narita, Atsushi Shimizu, Nahomi Imaeda, Chiho Goto, Kenji Matsui, Aya Kadota, Katsuyuki Miura, Masahiro Nakatochi, Keitaro Tanaka, Megumi Hara, Hiroaki Ikezaki, Masayuki Murata, Toshiro Takezaki, Daisaku Nishimoto, Keitaro Matsuo, Isao Oze, Nagato Kuriyama, Etsuko Ozaki, Haruo Mikami, Yohko Nakamura, Miki Watanabe, Sadao Suzuki, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Yoshikuni Kita, Kenji Wakai

The British journal of nutrition　126　(12)　1-9　2021/02/26

DOI： 10.1017/S0007114521000684 　

ISSN： 0007-1145

eISSN： 1475-2662
Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study.

Ryosuke Fujii, Asahi Hishida, Takeshi Nishiyama, Masahiro Nakatochi, Keitaro Matsuo, Hidemi Ito, Yuichiro Nishida, Chisato Shimanoe, Yasuyuki Nakamura, Tanvir Chowdhury Turin, Sadao Suzuki, Miki Watanabe, Rie Ibusuki, Toshiro Takezaki, Haruo Mikami, Yohko Nakamura, Hiroaki Ikezaki, Masayuki Murata, Kiyonori Kuriki, Nagato Kuriyama, Daisuke Matsui, Kokichi Arisawa, Sakurako Katsuura-Kamano, Mineko Tsukamoto, Takashi Tamura, Yoko Kubo, Takaaki Kondo, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai

Journal of epidemiology　32　(11)　483-488　2021/02/20

DOI： 10.2188/jea.JE20200540 　

More details Close

BACKGROUND: Inflammation is thought to be a risk factor for kidney disease. However, discussion is controversial whether inflammatory status is either a cause or an outcome of chronic kidney disease. We aimed to investigate the causal relationship between high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) using mendelian randomization (MR) approaches. METHODS: A total of 10,521 participants of the Japan Multi-institutional Collaborative Cohort Study was analyzed in this study. We used two-sample MR approaches (the inverse-variance weighted (IVW), the weighted median (WM), and the MR-Egger method) to estimate the effect of genetically determined hs-CRP on kidney function. We selected four and three hs-CRP associated single nucleotide polymorphisms (SNPs) as two instrumental variables (IV): IVCRP and IVAsian, based on SNPs previously identified in European and Asian populations. IVCRP and IVAsian explained 3.4% and 3.9% of the variation in hs-CRP, respectively. RESULTS: Using the IVCRP, genetically determined hs-CRP was not significantly associated with eGFR in the IVW and the WM methods (estimate per 1 unit increase in ln(hs-CRP), 95%CI: 0.000, -0.019 to 0.020 and -0.003, -0.019 to 0.014). For IVAsian, we found similar results using the IVW and the WM methods (estimate, 95% CI: -0.005, -0.020 to 0.010 and -0.004, -0.020 to 0.012). The MR-Egger method also showed no causal relationships between hs-CRP and eGFR (IVCRP: -0.008, -0.058 to 0.042; IVAsian: 0.001, -0.036 to 0.036). CONCLUSIONS: Our two-sample MR analyses with different IVs did not support a causal effect of hs-CRP on eGFR.
Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study.

Asahi Hishida, Masahiro Nakatochi, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Mineko Tsukamoto, Yuka Kadomatsu, Sadao Suzuki, Takeshi Nishiyama, Nagato Kuriyama, Isao Watanabe, Toshiro Takezaki, Daisaku Nishimoto, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Haruo Mikami, Miho Kusakabe, Isao Oze, Yuriko N Koyanagi, Yasuyuki Nakamura, Aya Kadota, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Michiaki Kubo, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai

Nagoya journal of medical science　83　(1)　183-194　2021/02

DOI： 10.18999/nagjms.83.1.183 　

More details Close

Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study, we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10-8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10-6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2 SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future.
Association between frequency of laughter and oral health among community-dwelling older adults: a population-based cross-sectional study in Japan. International-journal

Mayumi Hirosaki, Tetsuya Ohira, Kokoro Shirai, Naoki Kondo, Jun Aida, Tatsuo Yamamoto, Kenji Takeuchi, Katsunori Kondo

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation　30　(6)　1561-1569　2021/01/11

DOI： 10.1007/s11136-020-02752-7 　

More details Close

PURPOSE: Oral health has been reported to have an impact on the activities of daily life such as chewing, eating, and laughing, while psychological factors such as depression and loneliness have been reported to affect oral health. Little is known, however, about the association between laughter and oral health in older adults. This study examined the bidirectional association between the frequency of daily laughter and oral health in community-dwelling older Japanese adults. METHODS: Our cross-sectional study employed data from the 2013 Japan Gerontological Evaluation Study's self-reported survey, which included 11,239 male and 12,799 female community-dwelling independent individuals aged 65 years or older. We defined the oral health status by the number of remaining teeth. The association between the self-reported frequency of laughter (almost every day, 1-5 days per week, 1-3 days per month, or almost never) and oral health was examined using logistic regression analysis. RESULTS: The participants with 10 or more teeth were significantly more likely to laugh compared with the edentulous participants, after adjusting for all covariates. Compared with those who almost never laughed, those who laughed 1-5 days per week were significantly less likely to be edentulous. After stratifying by sex, similar results were found only in the men for both analyses. CONCLUSION: There was a significant bidirectional association between frequency of laughter and oral health that was independent of socioeconomic and lifestyle factors among older adults.
A genome-wide association study on meat consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort study. International-journal

Yasuyuki Nakamura, Akira Narita, Yoichi Sutoh, Nahomi Imaeda, Chiho Goto, Kenji Matsui, Naoyuki Takashima, Aya Kadota, Katsuyuki Miura, Masahiro Nakatochi, Takashi Tamura, Asahi Hishida, Ryoko Nakashima, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Toshiro Takezaki, Rie Ibusuki, Isao Oze, Hidemi Ito, Nagato Kuriyama, Etsuko Ozaki, Haruo Mikami, Miho Kusakabe, Hiroko Nakagawa-Senda, Sadao Suzuki, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Yoshikuni Kita, Kenji Wakai

Journal of nutritional science　10　e61　2021

DOI： 10.1017/jns.2021.49 　

ISSN： 2048-6790
Prolonged sedentary time under the state of emergency during the first wave of coronavirus disease 2019: Assessing the impact of work environment in Japan. International-journal

Teruhide Koyama, Kenji Takeuchi, Yudai Tamada, Jun Aida, Shihoko Koyama, Yusuke Matsuyama, Takahiro Tabuchi

Journal of occupational health　63　(1)　e12260　2021/01

DOI： 10.1002/1348-9585.12260 　

More details Close

OBJECTIVES: The coronavirus disease 2019 (COVID-19) outbreak and the resulting state of emergency have restricted work environments, which may contribute to increased duration of sedentary behaviors. This study investigated the self-reported sedentary time of Japanese workers during and after the first state of emergency (April 7 to May 25, 2020) and examined differences in sedentary time after starting work from home and according to job type. METHODS: We used cross-sectional data from the Japan COVID-19 and Society Internet Survey, a web-based questionnaire survey conducted from August to September 2020 (n = 11,623; age range 15-79 years; 63.6% male). Prolonged sedentary time was calculated by subtracting the sedentary time after the state of emergency (defined as the normal sedentary time) from that during the emergency, with adjustments using inverse probability weighting for being a respondent in an internet survey. RESULTS: An increase in sedentary time of at least 2 hours was reported by 12.8% of respondents who started working from home during the state of emergency, including 9.7% of salespersons and 7.7% of desk workers. After adjusting for potential confounders, the multivariate-adjusted odds ratios (ORs) for a prolonged sedentary time ≥2 hours was significantly higher in respondents who started to work from home (OR: 2.14, 95% confidence interval: 1.78-2.57), and certain job types (desk workers; OR: 1.56, 95% CI: 1.27-1.91, salespersons; OR: 2.03, 95% CI: 1.64-2.51). CONCLUSIONS: Working from home and non-physical work environments might be important predictors of prolonged sedentary time.
Associations between peroxisome proliferator-activated receptor γ (PPAR-γ) polymorphisms and serum lipids: Two cross-sectional studies of community-dwelling adults. International-journal Peer-reviewed

Takashi Matsunaga, Mariko Naito, Guang Yin, Asahi Hishida, Rieko Okada, Sayo Kawai, Tae Sasakabe, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Takashi Tamura, Kenji Takeuchi, Atsuyoshi Mori, Nobuyuki Hamajima, Kenji Wakai

Gene　762　145019-145019　2020/12/15

DOI： 10.1016/j.gene.2020.145019 　

More details Close

Dyslipidemia is a well-established risk factor for cardiovascular disease. Experimental studies have reported that peroxisome proliferator-activated receptor γ (PPAR-γ) regulates adipocyte differentiation, lipid storage, and glucose metabolism. Therefore, we examined the associations between PPAR-γ polymorphisms (rs1801282, rs3856806, rs12497191, rs1151999, and rs1152003) and serum lipids in two cross-sectional studies. In the Shizuoka area of the Japan Multi-Institutional Collaborative Cohort Study, we examined 4,952 participants (3,356 men and 1,596 women) in a baseline survey and 2,245 participants (1,550 men and 695 women) in a second survey 5 years later. Outcome measures were the prevalence of dyslipidemia (low-density lipoprotein-cholesterol [LDL-C] ≥ 140 mg/dl, high-density lipoprotein-cholesterol < 40 mg/dl, triglycerides ≥ 150 mg/dl, and/or use of cholesterol-lowering drugs) and the prevalence of high LDL-C (LDL-C ≥ 140 mg/dl and/or use of cholesterol-lowering drugs). Multivariate odds ratios (ORs) were estimated by using unconditional logistic regression models. A total of 2,114 and 1,431 individuals (42.7% and 28.9%) had dyslipidemia and high LDL-C in the baseline survey, respectively, as did 933 and 716 (41.6% and 31.9%), respectively, in the second survey. In the baseline study, compared with major allele homozygotes, minor allele homozygotes of rs3856806 and rs12497191 had a 42% (OR, 0.58; 95% confidence interval (CI), 0.39-0.85) and 23% (OR, 0.77; 95% CI, 0.60-0.99) lower risk of dyslipidemia, respectively, after adjustment for potential confounding factors. In addition, minor allele homozygotes of rs3856806 had a 45% (OR, 0.55; 95% CI, 0.35-0.86) lower risk of high LDL-C. Similar risk reductions were found in the second survey. In conclusion, rs3856806 and rs12497191 polymorphisms may be related to a lower risk of dyslipidemia and high LDL-C.
A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern. International-journal

Harumitsu Suzuki, Yasuyuki Nakamura, Keitaro Matsuo, Nahomi Imaeda, Chiho Goto, Akira Narita, Atsushi Shimizu, Naoyuki Takashima, Kenji Matsui, Katsuyuki Miura, Masahiro Nakatochi, Asahi Hishida, Takashi Tamura, Yuka Kadomatsu, Rieko Okada, Yuichiro Nishida, Chisato Shimanoe, Daisaku Nishimoto, Toshiro Takezaki, Isao Oze, Hidemi Ito, Hiroaki Ikezaki, Masayuki Murata, Daisuke Matsui, Etsuko Ozaki, Haruo Mikami, Yohko Nakamura, Sadao Suzuki, Miki Watanabe, Kokichi Arisawa, Hirokazu Uemura, Kiyonori Kuriki, Yukihide Momozawa, Michiaki Kubo, Yoshikuni Kita, Kenji Takeuchi, Kenji Wakai

European journal of clinical nutrition　75　(6)　937-945　2020/12/06

DOI： 10.1038/s41430-020-00823-z 　

More details Close

BACKGROUND/OBJECTIVES: Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. SUBJECTS/METHODS: We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1-10 omitting variants in the major histocompatibility region. RESULTS: We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10-8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. CONCLUSION: We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.
Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study. International-journal

Takashi Tamura, Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki, Daisuke Matsui, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Asahi Hishida, Tae Sasakabe, Sayo Kawai, Mariko Naito, Naoyuki Takashima, Aya Kadota, Keitaro Tanaka, Megumi Hara, Sadao Suzuki, Hiroko Nakagawa-Senda, Toshiro Takezaki, Ippei Shimoshikiryo, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kiyonori Kuriki, Kokichi Arisawa, Hirokazu Uemura, Kenji Takeuchi, Kenji Wakai

Scientific reports　10　(1)　18499-18499　2020/10/28

DOI： 10.1038/s41598-020-75267-3 　

More details Close

There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.
Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study. Peer-reviewed

Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Satomi Tomida, Ritei Uehara, Yuichiro Nishida, Chisato Shimanoe, Asahi Hishida, Takashi Tamura, Mineko Tsukamoto, Yuka Kadomatsu, Isao Oze, Keitaro Matsuo, Haruo Mikami, Yohko Nakamura, Rie Ibusuki, Toshiro Takezaki, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Hirokazu Uemura, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Kenji Wakai

Journal of atherosclerosis and thrombosis　27　(10)　1097-1107　2020/10/01

DOI： 10.5551/jat.54320 　

More details Close

AIM: Accumulating evidence reveals that sedentary behavior is associated with mortality and cardiometabolic disease; however, there are potential age and sex differences in sedentary behavior and health outcomes that have not been adequately addressed. This study aimed to determine the association of sedentary behavior with cardiometabolic diseases such as hypertension, dyslipidemia, diabetes mellitus, and its risk factors in a large Japanese population according to age and sex. METHODS: Using data from the Japan Multi-Institutional Collaborative Cohort Study obtained from baseline surveys, data of 62,754 participants (27,930 males, 34,824 females) were analyzed. This study uses a cross-sectional design and self-administered questionnaires to evaluate sedentary time and anamnesis. For the logistic regression analysis, sedentary time ＜5 h/day was used as the reference and then adjusted for age, research areas, leisure-time metabolic equivalents, and alcohol and smoking status. From the analysis of anthropometric and blood examinations, 35,973 participants (17,109 males, 18,864 females) were analyzed. RESULTS: For hypertension and diabetes, sedentary time was associated with a significantly higher proportion of male participants. Both sexes were associated with a significantly higher proportion of participants with dyslipidemia. Participants who had longer sedentary time tended to have increased levels of blood pressure, triglycerides, and non-high-density lipoprotein cholesterol (HDL-C), and decreased levels of HDL-C, especially in the 60-69 years group. CONCLUSIONS: Independent of leisure-time physical activity, sedentary time was associated with cardiometabolic diseases in a large Japanese population classified by age and sex. Our findings indicate that regularly interrupting and replacing sedentary time may contribute to better physical health-related quality of life.
Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Peer-reviewed

Kenji Takeuchi, Mariko Naito, Sayo Kawai, Mineko Tsukamoto, Yuka Kadomatsu, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Masahiro Nakatochi, Tae Sasakabe, Shuji Hashimoto, Hidetaka Eguchi, Yukihide Momozawa, Hiroaki Ikezaki, Masayuki Murata, Norihiro Furusyo, Keitaro Tanaka, Megumi Hara, Yuichiro Nishida, Keitaro Matsuo, Hidemi Ito, Isao Oze, Haruo Mikami, Yohko Nakamura, Miho Kusakabe, Toshiro Takezaki, Rie Ibusuki, Ippei Shimoshikiryo, Sadao Suzuki, Takeshi Nishiyama, Miki Watanabe, Teruhide Koyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Yoshikuni Kita, Hirotsugu Ueshima, Kenji Matsui, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano, Sho Nakamura, Hiroto Narimatsu, Nobuyuki Hamajima, Hideo Tanaka, Kenji Wakai

Journal of epidemiology　31　(12)　660-668　2020/09/19

DOI： 10.2188/jea.JE20200147 　

More details Close

BACKGROUND: The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene-environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. METHODS: The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history, and collected peripheral blood samples. RESULTS: The baseline survey included 92,610 adults (mean age: 55.2 [9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65-69 years for men and 60-64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. CONCLUSIONS: The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.
Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study. International-journal Peer-reviewed

Kokichi Arisawa, Sakurako Katsuura-Kamano, Hirokazu Uemura, Nguyen Van Tien, Asahi Hishida, Takashi Tamura, Yoko Kubo, Mineko Tsukamoto, Keitaro Tanaka, Megumi Hara, Toshiro Takezaki, Daisaku Nishimoto, Teruhide Koyama, Etsuko Ozaki, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Aya Kadota, Naoyuki Takashima, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Keitaro Matsuo, Haruo Mikami, Yohko Nakamura, Kenji Takeuchi, Kenji Wakai

Nutrients　12　(6)　2020/05/29

DOI： 10.3390/nu12061605 　

More details Close

The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35-69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12-1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.
Does laughter predict onset of functional disability and mortality among older Japanese adults? the JAGES prospective cohort study. Peer-reviewed

Yudai Tamada, Kenji Takeuchi, Chikae Yamaguchi, Masashige Saito, Tetsuya Ohira, Kokoro Shirai, Katsunori Kondo

Journal of epidemiology　31　(5)　301-307　2020/05/16

DOI： 10.2188/jea.JE20200051 　

More details Close

BACKGROUND: While laughter is broadly recognized as a good medicine, a potential preventive effect of laughter on disability and death is still being debated. Accordingly, we investigated the association between the frequency of laughter and onset of functional disability and all-cause mortality among the older adults in Japan. METHODS: The data for a 3-year follow-up cohort including 14,233 individuals (50.3% men) aged ≥ 65 years who could independently perform the activities of daily living and participated in the Japan Gerontological Evaluation Study were analyzed. The participants were classified into four categories according to their frequency of laughter (almost every day, 1-5 days/week, 1-3 days/month, and never or almost never). We estimated the risks of functional disability and all-cause mortality in each category using a Cox proportional hazards model. RESULTS: During follow-up, 605 (4.3%) individuals developed functional disability, identified by new certification for the requirement of Long-Term Care Insurance, and 659 (4.6%) deaths were noted. After adjusting for the potential confounders, the multivariate-adjusted hazard ratio of functional disability increased with a decrease in the frequency of laughter (p for trend = 0.04). The risk of functional disability was 1.42 times higher for individuals who laughed never or almost never than for those who laughed almost every day. No such association was observed with the risk of all-cause mortality (p for trend = 0.39). CONCLUSIONS: Low frequency of laughter is associated with increased risks of functional disability. Laughter may be an early predictor of functional disability later on in life.
Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study. International-journal Peer-reviewed

Naoki Choda, Kenji Wakai, Mariko Naito, Nahomi Imaeda, Chiho Goto, Kenta Maruyama, Yuka Kadomatsu, Mineko Tsukamoto, Tae Sasakabe, Yoko Kubo, Rieko Okada, Sayo Kawai, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Atsuyoshi Mori, Nobuyuki Hamajima

Nutrition journal　19　(1)　2-2　2020/01/09

DOI： 10.1186/s12937-019-0515-6 　

More details Close

BACKGROUND: Mental health has become a major public health issue worldwide. Biological and epidemiological studies suggest diet has a role in the prevention or cure of mental disorders. However, further research is required to elucidate the relationship between diet and mental health. This study aimed to investigate associations between dietary intake of nutrients (macronutrients, vitamins, calcium, and fatty acids) and food groups (fish, meat and chicken, dairy products, and vegetables) and mental health among middle-aged Japanese in cross-sectional and prospective studies. METHODS: In total, 9298 men and women that participated in two areas of the Japan Multi-Institutional Collaborative Cohort Study were eligible for analysis at the baseline (cross-sectional) survey. Of these, 4701 participants were followed for about 5 years and included in the follow-up (prospective) analysis. The 12-item General Health Questionnaire (GHQ) was used to assess participants' general mental health status over the past several weeks. The average intake of 46 foods over the past year was assessed by a validated food frequency questionnaire. We also evaluated lifestyle and medical factors using a self-administered questionnaire. A cross-sectional logistic regression analysis was performed to estimate odds ratios for a GHQ score ≥ 4 (poor mental health) according to dietary intake of foods/nutrients at baseline. The prospective study used baseline dietary and lifestyle factors and GHQ scores at follow-up. RESULTS: The cross-sectional logistic regression analysis showed vegetables, protein, calcium, vitamin D, carotene and n-3 highly-polyunsaturated fatty acids were inversely associated with a GHQ score ≥ 4. On the other hand, mono-unsaturated fatty acids showed a positive association with higher GHQ score. The prospective logistic regression analysis found dairy products, calcium, vitamin B2, and saturated fatty acids were inversely correlated with a GHQ score ≥ 4. Calcium was associated with GHQ scores in both the cross-sectional and follow-up studies. In the follow-up study, the multivariable-adjusted odds ratio for a GHQ score ≥ 4 was 0.71 (95% confidence interval, 0.55-0.92) for the highest versus lowest quartiles of calorie-adjusted dietary calcium intake. CONCLUSION: Consuming particular nutrients and foods, especially calcium and dairy products, may lead to better mental health in Japanese adults.
Longitudinal associations of toothbrushing with obesity and hyperglycemia

Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Akihiko Tanaka, Shino Suma, Takashi Shinagawa, Yoshihiro Shimazaki, Yoshihisa Yamashita

Journal of Epidemiology　30　(12)　556-565　2020

DOI： 10.2188/jea.JE20190165 　

ISSN： 0917-5040

eISSN： 1349-9092
Dentist gender-related differences in patients' oral health behaviour. Peer-reviewed

Kenji Takeuchi, Yuki Noguchi, Yukie Nakai, Toshiyuki Ojima, Yoshihisa Yamashita

Journal of oral science　62　(1)　32-35　2020

DOI： 10.2334/josnusd.18-0462 　

More details Close

This study aimed at determining whether oral health behavior differs between patients regularly checked by male and female dentists. The analysis was based on a cross-sectional survey of 354 Japanese community residents (median age = 54 years; 145 men and 209 women) conducted in a municipality from January to February 2017. Data on demographic characteristics and factors associated with oral health behavior were obtained through self-administered questionnaires. The association between regular dentist gender and patients' regular dental care check-up and interdental cleaning performance was examined after adjusting for potential confounders. Among respondents, 88.7% and 11.3% reported having male and female regular dentists, respectively. In a multivariate logistic regression model, patients regularly checked by female dentists had an increased likelihood of visiting their dentist for dental care check-up at least once every year (odds ratio [OR] = 2.23, 95% confidence interval [CI] = 1.09-4.55)and using an interdental cleaner (OR = 2.62, 95% CI = 1.03-6.71) compared to those regularly checked by male dentists. Patients regularly checked by female dentists tended to have more preventive oral health behaviors than those regularly checked by male dentists. These findings suggest that dentist gender has important clinical implications for patients' oral health behavior.
Impact of PSCA polymorphisms on the risk of duodenal ulcer. Peer-reviewed

Yoshiaki Usui, Keitaro Matsuo, Isao Oze, Tomotaka Ugai, Yuriko Koyanagi, Yoshinobu Maeda, Hidemi Ito, Asahi Hishida, Kenji Takeuchi, Takashi Tamura, Mineko Tsukamoto, Yuka Kadomatsu, Megumi Hara, Yuichiro Nishida, Ippei Shimoshikiryo, Toshiro Takezaki, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Sadao Suzuki, Miki Watanabe, Hiroko Nakagawa-Senda, Haruo Mikami, Yohko Nakamura, Kokichi Arisawa, Hirokazu Uemura, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Hiroaki Ikezaki, Masayuki Murata, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai

Journal of epidemiology　31　(1)　12-20　2019/12/14

DOI： 10.2188/jea.JE20190184 　

More details Close

BACKGROUND: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population. METHODS: PSCA six SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CI) for association between the SNPs and risk of DU/GU. RESULTS: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18-1.51; P=2.28×10-6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs. CONCLUSIONS: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
Path from epidemiological studies to policy Peer-reviewed

Kenji Takeuchi

Health Science and Health Care　19　(2)　62-65　2019/12
Publisher:
ISSN： 1881-1892
Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease Peer-reviewed

Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y

Journal of Dental Research　98　(5)　534-540　2019/03
Publisher: {SAGE} Publications
DOI： 10.1177/0022034519833630 　

ISSN： 0022-0345

eISSN： 1544-0591
Denture Wearing Moderates the Association between Aspiration Risk and Incident Pneumonia in Older Nursing Home Residents: A Prospective Cohort Study. Peer-reviewed

Takeuchi K, Izumi M, Furuta M, Takeshita T, Shibata Y, Kageyama S, Okabe Y, Akifusa S, Ganaha S, Yamashita Y

International journal of environmental research and public health　16　(4)　2019/02

DOI： 10.3390/ijerph16040554 　

ISSN： 1661-7827

eISSN： 1660-4601
Characteristics of the Salivary Microbiota in Patients With Various Digestive Tract Cancers. International-journal Peer-reviewed

Kageyama S, Takeshita T, Takeuchi K, Asakawa M, Matsumi R, Furuta M, Shibata Y, Nagai K, Ikebe M, Morita M, Masuda M, Toh Y, Kiyohara Y, Ninomiya T, Yamashita Y

Frontiers in microbiology　10　1780-1780　2019

DOI： 10.3389/fmicb.2019.01780 　

More details Close

The salivary microbiota is constantly swallowed and delivered to the digestive tract. These bacteria may be associated with gastrointestinal diseases. This case-control study examined the salivary microbiota in patients with digestive tract cancer (DTC) and evaluated their differential distribution based on the cancer sites. We collected saliva samples from 59 patients with cancer in any part of the digestive tract (tongue/pharynx, esophagus, stomach, and large intestine) and from 118 age- and sex-matched control subjects. There was no significant difference in periodontal status between DTC patients and control subjects (P = 0.72). We examined the bacterial diversity and composition in saliva by 16S ribosomal RNA gene sequencing. Salivary bacterial diversity in DTC patients was significantly higher than that in control subjects [number of operational taxonomic units (OTUs), P = 0.02; Shannon index, P < 0.01; Chao1, P = 0.04]. Eleven differentially abundant OTUs in DTC patients were identified using the linear discriminant analysis effect size (LEfSe) method. Based on the cancer sites, the diversity of salivary bacteria was especially higher in tongue/pharyngeal or esophageal cancer patients than in control subjects. Among the 11 differentially abundant OTUs in DTC patients, an OTU corresponding to Porphyromonas gingivalis was more abundant in the saliva of all groups of DTC patients compared to that in control subjects, and an OTU corresponding to Corynebacterium species was more abundant in all groups other than gastric cancer patients (P < 0.01). In addition, the relative abundances of OTUs corresponding to Fusobacterium nucleatum, Streptococcus parasanguinis II, and Neisseria species were significantly higher in tongue/pharyngeal cancer patients compared to their abundances in control subjects (P < 0.01). The relative abundance of an OTU corresponding to the Neisseria species was also significantly higher in gastric cancer patients and that of an OTU corresponding to Actinomyces odontolyticus was significantly higher in colorectal cancer patients (P < 0.01). These results suggest that the salivary microbiota might be associated with various digestive tract cancers.
Effects of xylitol-containing chewing gum on the oral microbiota Peer-reviewed

Takeuchi K, Asakawa M, Hashiba T, Takeshita T, Saeki Y, Yamashita Y

Journal of oral science　60　(4)　588-594　2018/11

DOI： 10.2334/josnusd.17-0446 　

ISSN： 1343-4934

eISSN： 1880-4926
Comparison of the periodontal condition in Korean and Japanese adults: a cross-sectional study Peer-reviewed

Furuta M, Takeuchi K, Shimazaki Y, Takeshita T, Shibata Y, Hata J, Yoshida D, Park DY, Ninomiya T, Yamashita Y

BMJ Open　8　(11)　2018/11

DOI： 10.1136/bmjopen-2018-024332 　

ISSN： 2044-6055
Tongue Microbiota and Oral Health Status in Community-Dwelling Elderly Adults. International-journal Peer-reviewed

Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y

mSphere　3　(4)　2018/08

DOI： 10.1128/mSphere.00332-18 　

More details Close

Tongue microbiota are a dominant source of oral microbial populations that are ingested with saliva, and therefore careful attention is required for the maintenance of health of elderly adults, who are susceptible to aspiration of oral contents. This study aimed to investigate the variation in tongue microbiota among community-dwelling elderly adults. Following a dental examination, tongue coating was collected from a 15-mm-diameter circular area at the center of the tongue dorsum of 506 elderly adults aged 70 to 80 years inhabiting the town of Hisayama, Japan. The microbial composition and density were determined by a 16S rRNA gene sequencing approach using a next-generation sequencer and quantitative PCR analysis, respectively. Co-occurrence network analysis identified two cohabiting groups of predominant commensals, one of which was primarily composed of Prevotella histicola, Veillonella atypica, Streptococcus salivarius, and Streptococcus parasanguinis; these organisms have been previously associated with an increased risk of mortality due to pneumonia in the frail elderly. This bacterial group was more predominant in the elderly with fewer teeth, a higher plaque index, and more dental caries experience, whereas the total bacterial density was independent of these traits. A higher density of fungi was also observed in the elderly with these traits, as well as in individuals who wore dentures. These results suggest that elderly adults with poorer oral health swallow a more dysbiotic microbiota formed on the tongue.IMPORTANCE Aspiration of oral contents can lead to pneumonia, which is a major cause of death among elderly adults susceptible to swallowing impairments. Tongue microbiota are a dominant source of oral microbial populations that are ingested with saliva. This large-scale population-based study revealed variations in the tongue microbiota among community-dwelling elderly adults. The total bacterial density was independent of the conditions of teeth surrounding the tongue, whereas the microbiota composition, especially the relative abundances of predominant commensals, showed an association with tooth conditions. Our results demonstrate that the elderly with fewer teeth, poorer dental hygiene, and more dental caries experience constantly ingest more dysbiotic microbiota, which could be harmful for their respiratory health.
Decreased cognitive function is associated with dysphagia risk in nursing home older residents International-journal Peer-reviewed

Yatabe N, Takeuchi K, first authorship, Izumi M, Furuta M, Takeshita T, Shibata Y, Suma S, Kageyama S, Ganaha S, Tohara H, Yamashita Y

Gerodontology　35　(4)　376-381　2018/07

DOI： 10.1111/ger.12366 　

ISSN： 0734-0664

More details Close

OBJECTIVE: To examine the association between cognitive function and dysphagia risk among Japanese nursing home residents. BACKGROUND: Reduction in cognitive function can influence the intake of food during swallowing, and may be an aggravating factor in dysphagia. METHODS: This cross-sectional study included 236 residents aged ≥60 years from eight nursing homes. Screening of dysphagia, especially aspiration risk, was conducted using the Modified Water Swallow Test, whose scores from one to three were classified as at risk of dysphagia. Cognitive function was evaluated using Mini-Mental State Examination (MMSE). Number of teeth and occlusal support were evaluated by clinical examination. The participants were stratified into dentulous and edentulous groups, because the number of teeth could influence swallowing function. The odds ratio (OR) and 95% confidence interval (CI) for dysphagia risk based on the scores of MMSE were calculated using logistic regression. Demographic characteristics, activity of daily living, comorbidities, health behaviour and occlusal support were used as covariates. RESULTS: Among the 236 participants (111 dentulous participants and 125 edentulous participants) included in our analysis, 16.9% belonged to risk of dysphagia. Dentulous participants with higher scores of MMSE tended to have significantly lower odds of dysphagia risk after adjusting for covariates (OR = 0.87, 95% CI = 0.80-0.96). Despite the lack of significant differences, edentulous participants with higher score of MMSE tended to have lower odds of dysphagia risk (OR = 0.92, 95% CI = 0.83-1.00). CONCLUSION: Decreased cognitive function may be an independent predictor of dysphagia among dentulous and edentulous adults.
Periodontitis modifies the association between smoking and chronic obstructive pulmonary disease in Japanese men Peer-reviewed

Jane Harland, Michiko Furuta, Kenji Takeuchi, Shunichi Tanaka, Yoshihisa Yamashita

Journal of Oral Science　60　(2)　226-231　2018/06/01
Publisher: Nihon University, School of Dentistry
DOI： 10.2334/josnusd.17-0225 　

ISSN： 1880-4926 1343-4934
Tooth loss, swallowing dysfunction and mortality in Japanese older adults receiving home care services Peer-reviewed

Michiko Furuta, Kenji Takeuchi, Munehisa Adachi, Toshinori Kinoshita, Nobuoki Eshima, Sumio Akifusa, Takeshi Kikutani, Yoshihisa Yamashita

Geriatrics and Gerontology International　18　(6)　873-880　2018/06/01
Publisher: Blackwell Publishing
DOI： 10.1111/ggi.13271 　

ISSN： 1447-0594 1444-1586
Relationship of toothbrushing to metabolic syndrome in middle-aged adults Peer-reviewed

Akihiko Tanaka, Kenji Takeuchi, Michiko Furuta, Toru Takeshita, Shino Suma, Takashi Shinagawa, Yoshihiro Shimazaki, Yoshihisa Yamashita

Journal of Clinical Periodontology　45　(5)　538-547　2018/05/01
Publisher: Blackwell Munksgaard
DOI： 10.1111/jcpe.12876 　

ISSN： 1600-051X 0303-6979
Periodic and Regional Differences in Estimated Consultation Rate for Periodontal Disease Screening in Japan Peer-reviewed

YATABE Naoko, FURUTA Michiko, TAKEUCHI Kenji, SUMA Shino, FUCHIDA Shinya, YAMAMOTO Tatsuo, YAMASHITA Yoshihisa

JOURNAL OF DENTAL HEALTH　68　(2)　92-100　2018/04
Publisher: 一般社団法人口腔衛生学会
DOI： 10.5834/jdh.68.2_92 　

ISSN： 0023-2831

eISSN： 2189-7379

More details Close

The Japanese Ministry of Health, Labour, and Welfare has been conducting periodontal disease screening as a part of senior health services since 1995, and as an independent medical examination for individuals aged between 40 and 50 years since 2000. This service has been extended for individuals aged between 60 and 70 years since 2004. The consultation rate for periodontal disease screening in Japan has not been reported recently, and so its current status is unknown. In this study, we estimated and assessed periodic and regional differences in the consultation rate for periodontal disease screening over a period of 15 years. We calculated the consultation rate for periodontal disease screening by dividing the number of individuals screened for periodontal disease (as recorded in the regional health care and health promotion service report), by the total population (as per the Basic Resident Register and multiplying by 100), from the year 2000 to 2015. At the national level, the consultation rate was 1.27% in 2000, 2.74% in 2005, 3.34% in 2010, and 4.30% in 2015. The highest rate in a prefecture was 13.33% and the lowest rate was 0.34% reveling that consultation rates differed markedly among prefectures. Multiple linear regression analysis that factored in socio-demographic variables revealed that prefectures with larger total numbers of oral examinations and health guidance sessions (partial correlation coefficient= 0.356; p=0.016), a larger proportion of health care costs (partial correlation coefficient=0.295; p=0.049), and a higher level of available funds (partial correlation coefficient=0.337; p=0.024), had higher consultation rates. It was concluded that the total consultation rate showed an increasing trend, while the regional differences widened. The total consultation rate may increase in the future by focusing efforts on improving regional consultation rates.
歯周疾患検診受診率の推移とその地域差に関する検討 Peer-reviewed

矢田部尚子, 古田美智子, 竹内研時, 須磨紫乃, 渕田慎也, 山本龍生, 山下喜久

口腔衛生学会雑誌　68　(1)　45-45　2018/01
Publisher:
ISSN： 0023-2831
Periodontal status and lung function decline in the community: the Hisayama study Peer-reviewed

Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y

Scientific Reports　8　(1)　13354　2018

DOI： 10.1038/s41598-018-31610-3 　

eISSN： 2045-2322
Characterization of oral microbiota and acetaldehyde production. International-journal Peer-reviewed

Yokoyama S, Takeuchi K, first authorship, Shibata Y, Kageyama S, Matsumi R, Takeshita T, Yamashita Y

Journal of oral microbiology　10　(1)　1492316-1492316　2018

DOI： 10.1080/20002297.2018.1492316 　

More details Close

Background: Neisseria has been reported to be a high producer of acetaldehyde (ACH), a carcinogen, from ethanol in vitro, but no information exists regarding whether the ACH production depends on oral microbiota profiles. Objective and Design: To explore the salivary microbiota profiles with respect to ACH production ability in the oral cavity using a cross-sectional design. Results: Using 16S rRNA gene amplicon sequencing, we classified 100 saliva samples into two types of communities (I and II). Salivary ACH production ability from ethanol was measured using gas chromatography and was found to vary over a 30-fold range. ACH production ability was significantly higher in the type I community, wherein the relative abundance of Neisseria species was significantly lower. Multivariate logistic regression analysis showed that the subjects with the type I community exhibited significantly higher probability of high ACH production ability than those with the type II community (P = 0.014). Moreover, the relative abundance of Neisseria species was inversely correlated with the ACH production ability (P = 0.002). Conclusion: The salivary microbiota profile with a lower relative abundance of Neisseria species was independently associated with high ACH production ability, despite Neisseria species are dominant producers of ACH in vitro.
Gender-dependent associations between occupational status and untreated caries in Japanese adults Peer-reviewed

Yuriko HARADA, Kenji TAKEUCHI, Michiko FURUTA, Akihiko TANAKA, Shunichi TANAKA, Naohisa WADA, Yoshihisa YAMASHITA

Industrial Health　56　(6)　539-544　2018
Publisher: National Institute of Industrial Health
DOI： 10.2486/indhealth.2018-0062 　

ISSN： 0019-8366

eISSN： 1880-8026
Association of Regional Inequality in 12-year-olds' Decayed, Missing, or Filled Permanent Teeth in Fukuoka Prefecture with Community-level Socioeconomic Status Peer-reviewed

OKABE Yuka, TAKEUCHI Kenji, FURUTA Michiko, HIRASE Hisayoshi, MATSUDA Kouichi, SAKATA Hitoshi, SUGIHARA Eiji, YAMASHITA Yoshihisa

JOURNAL OF DENTAL HEALTH　68　(1)　15-20　2018/01
Publisher: 一般社団法人口腔衛生学会
DOI： 10.5834/jdh.68.1_15 　

ISSN： 0023-2831
Swallowing disorders and 1-year functional decline in community-dwelling older adults receiving home care Peer-reviewed

K. Takeuchi, M. Furuta, Y. Okabe, S. Suma, T. Takeshita, S. Akifusa, M. Adachi, T. Kinoshita, T. Kikutani, Y. Yamashita

JOURNAL OF ORAL REHABILITATION　44　(12)　982-987　2017/12

DOI： 10.1111/joor.12577 　

ISSN： 0305-182X

eISSN： 1365-2842
Relationships of variations in the tongue microbiota and pneumonia mortality in nursing home residents. International-journal Peer-reviewed

Kageyama S, Takeshita T, Furuta M, Tomioka M, Asakawa M, Suma S, Takeuchi K, Shibata Y, Iwasa Y, Yamashita Y

The journals of gerontology. Series A, Biological sciences and medical sciences　73　(8)　1097-1102　2017/10

DOI： 10.1093/gerona/glx205 　

ISSN： 1079-5006

More details Close

Background: Aspiration of oral debris, containing dense oral bacteria, is a major cause of pneumonia in elderly adults. This study investigated the relationship between tongue microbiota composition and incidence of pneumonia-related deaths, in nursing home residents. Methods: The subjects were assessed for health conditions, including their tongue microbiota, at baseline. We determined tongue microbiota profiles by 16S ribosomal RNA gene sequencing and clustering approach. All subjects (n = 173) were followed prospectively for a median of 19 months to assess the incidence of all-cause death, including pneumonia-related death. We evaluated risk estimates of microbiota effects on death using multivariate Cox proportional hazards regression analysis. Results: Tongue microbiota were classified into two community types: type I was dominated by Prevotella and Veillonella species, while type II was dominated by Neisseria and Fusobacterium species. The subjects with type I microbiota exhibited a significantly greater risk of all-cause death (adjusted hazard ratio [aHR] = 3.79, 95% confidence interval [CI] = 1.38-10.39) and pneumonia-related death (aHR = 13.88, 95% CI = 1.64-117.21), than those with type II microbiota. There was no significant association between microbiota type and other-cause death. Conclusions: The tongue microbiota type was significantly associated with an increased mortality risk from pneumonia in nursing home residents.
Associations of Oral Health Status and Dental Health Service Utilization with Dental and Medical Expenditures Peer-reviewed

竹内研時, 佐藤遊洋, 須磨紫乃, 古田美智子, 岡部優花, 田中照彦, 小坂健, 山下喜久

口腔衛生学会雑誌　67　(3)　160‐171-171　2017/07
Publisher: Japanese Society for Oral Health
DOI： 10.5834/jdh.67.3_160 　

ISSN： 0023-2831

More details Close

It was recently reported that dental care management not only reduces the economic burden caused by dental diseases, but also helps to prevent the deterioration of lifestyle-related diseases. This study was aimed to comprehensively survey the findings to date on how the oral health status and dental health service utilization are associated with dental and medical expenditures. Investigation focused on: (1) association of the oral health status with dental and medical expenses, and (2) association of the utilization of dental health services with dental and medical expenses. An initial combination of electronic-database and hand searches yielded 32 relevant reports, which were then intensively reviewed.(1) Many studies revealed that patients with 20 or more teeth incur lower dental costs, and those with more remaining teeth incur lower medical costs. In addition, there were reports that the presence of dental disease, primarily periodontal disease, is associated with higher dental and medical expenses. (2) There were reports that participating in regular preventive visits to a dental clinic or dental check-ups is associated with lower dental and medical costs.The results of this study reveal that dental and medical expenditures are particularly associated with the number of remaining teeth, and with participation in dental health activity such as regular preventive dental visits. Caries and periodontal disease are the leading causes of tooth loss: the present findings suggest that continuing regular dental check-ups from a young age focused on the prevention of such dental diseases could make a consistent contribution to controlling costs of not only dental care but also general medical care.
Tooth Loss and Risk of Dementia in the Community: the Hisayama Study Peer-reviewed

Kenji Takeuchi, Tomoyuki Ohara, Michiko Furuta, Toru Takeshita, Yukie Shibata, Jun Hata, Daigo Yoshida, Yoshihisa Yamashita, Toshiharu Ninomiya

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　65　(5)　E95-E100　2017/05

DOI： 10.1111/jgs.14791 　

ISSN： 0002-8614

eISSN： 1532-5415
Association between posterior teeth occlusion and functional dependence among older adults in nursing homes in Japan Peer-reviewed

Kenji Takeuchi, Maya Izumi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Shinya Kageyama, Seijun Ganaha, Yoshihisa Yamashita

GERIATRICS & GERONTOLOGY INTERNATIONAL　17　(4)　622-627　2017/04

DOI： 10.1111/ggi.12762 　

ISSN： 1444-1586

eISSN： 1447-0594
Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis Peer-reviewed

Shinya Kageyama, Toru Takeshita, Mikari Asakawa, Yukie Shibata, Kenji Takeuchi, Wataru Yamanaka, Yoshihisa Yamashita

PLOS ONE　12　(4)　2017/04

DOI： 10.1371/journal.pone.0174782 　

ISSN： 1932-6203
Posterior teeth occlusion and dysphagia risk in older nursing home residents: a cross-sectional observational study Peer-reviewed

Y. Okabe, K. Takeuchi, M. Izumi, M. Furuta, T. Takeshita, Y. Shibata, S. Kageyama, S. Ganaha, Y. Yamashita

JOURNAL OF ORAL REHABILITATION　44　(2)　89-95　2017/02

DOI： 10.1111/joor.12472 　

ISSN： 0305-182X

eISSN： 1365-2842
認知機能が嚥下機能を介して栄養状態に与える効果の検証

竹内研時, 泉繭依, 古田美智子, 岡部優花, 我那覇生純, 山下喜久

日本摂食・嚥下リハビリテーション学会雑誌　20　(3)　S152-S152　2016/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
歯科医療・口腔保健の2050年までの研究課題 Peer-reviewed

竹内研時, 深井穫博

ヘルスサイエンス・ヘルスケア　16　(2)　85-90　2016/12
Publisher: 深井保健科学研究所
ISSN： 1881-1892
Effects of oral care with tongue cleaning on coughing ability in geriatric care facilities: a randomised controlled trial Peer-reviewed

M. Izumi, K. Takeuchi, S. Ganaha, S. Akifusa, Y. Yamashita

JOURNAL OF ORAL REHABILITATION　43　(12)　953-959　2016/12

DOI： 10.1111/joor.12451 　

ISSN： 0305-182X

eISSN： 1365-2842
地域住民における口腔の健康状態と生活習慣病の関連性の検討久山町研究

古田美智子, 竹内研時, 竹下徹, 柴田幸江, 二宮利治, 清原裕, 山下喜久

口腔衛生学会雑誌　66　(5)　465-474　2016/10
Publisher: (一社)日本口腔衛生学会
DOI： 10.5834/jdh.66.5_465 　

ISSN： 0023-2831
Swallowing function and nutritional status in Japanese elderly people receiving home-care services: A 1-year longitudinal study Peer-reviewed

Y. Okabe, M. Furuta, S. Akifusa, K. Takeuchi, M. Adachi, T. Kinoshita, T. Kikutani, S. Nakamura, Y. Yamashita

JOURNAL OF NUTRITION HEALTH & AGING　20　(7)　697-704　2016/07

DOI： 10.1007/s12603-015-0645-2 　

ISSN： 1279-7707

eISSN： 1760-4788
Tooth loss and metabolic syndrome in middle-aged Japanese adults Peer-reviewed

Michiko Furuta, An Liu, Takashi Shinagawa, Kenji Takeuchi, Toru Takeshita, Yoshihiro Shimazaki, Yoshihisa Yamashita

JOURNAL OF CLINICAL PERIODONTOLOGY　43　(6)　482-491　2016/06

DOI： 10.1111/jcpe.12523 　

ISSN： 0303-6979

eISSN： 1600-051X
Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study Peer-reviewed

Toru Takeshita, Shinya Kageyama, Michiko Furuta, Hidenori Tsuboi, Kenji Takeuchi, Yukie Shibata, Yoshihiro Shimazaki, Sumio Akifusa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita

SCIENTIFIC REPORTS　6　2016/02

DOI： 10.1038/srep22164 　

ISSN： 2045-2322
Dental Caries and Community Socioeconomic Status in Japanese and Chinese Children : An Ecological Study

LIU An, FURUTA Michiko, TAKEUCHI Kenji, YAMASHITA Yoshihisa

口腔衛生学会雑誌　66　(1)　32-38　2016/01/30
Publisher: 有限責任中間法人日本口腔衛生学会
DOI： 10.5834/jdh.66.1_32 　

ISSN： 0023-2831

More details Close

Our aim was to compare the dental caries status between Japanese and Chinese children and to examine the association between the community socioeconomic status (SES) and dental caries. We made use of data collected in national surveys in Japan and China. Japanese children aged 5 and 12 years old had more filled teeth than Chinese children. As a result of this large number of filled teeth, Japanese 5-year-old children had fewer decayed teeth than Chinese children. Japanese 12-year-old children who lived in communities with a high SES had significantly fewer dental caries than those who lived in communities with a lower SES. Conversely, in China, dental caries was positively associated with the community SES. This suggests that the association between dental caries and the community SES differs among countries.
Association of periodontal status with liver abnormalities and metabolic syndrome Peer-reviewed

Aisyah Ahmad, Michiko Furuta, Takashi Shinagawa, Kenji Takeuchi, Toru Takeshita, Yoshihiro Shimazaki, Yoshihisa Yamashita

JOURNAL OF ORAL SCIENCE　57　(4)　335-343　2015/12

DOI： 10.2334/josnusd.57.335 　

ISSN： 1343-4934

eISSN： 1880-4926
Posterior Teeth Occlusion Associated with Cognitive Function in Nursing Home Older Residents: A Cross-Sectional Observational Study Peer-reviewed

Kenji Takeuchi, Maya Izumi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Shinya Kageyama, Seijun Ganaha, Yoshihisa Yamashita

PLOS ONE　10　(10)　e0141737　2015/10

DOI： 10.1371/journal.pone.0141737 　

ISSN： 1932-6203
Serum antibody to Porphyromonas gingivalis and periodontitis progression: the Hisayama Study Peer-reviewed

Kenji Takeuchi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Yoshihiro Shimazaki, Sumio Akifusa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita

JOURNAL OF CLINICAL PERIODONTOLOGY　42　(8)　719-725　2015/08

DOI： 10.1111/jcpe.12431 　

ISSN： 0303-6979

eISSN： 1600-051X
Chewing Xylitol Gum Improves Self-Rated and Objective Indicators of Oral Health Status under Conditions Interrupting Regular Oral Hygiene Peer-reviewed

Takafumi Hashiba, Kenji Takeuchi, Yoshihiro Shimazaki, Toru Takeshita, Yoshihisa Yamashita

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　235　(1)　39-46　2015/01

DOI： 10.1620/tjem.235.39 　

ISSN： 0040-8727

eISSN： 1349-3329
Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers Peer-reviewed

Michiko Furuta, Yoshihiro Shimazaki, Shunichi Tanaka, Kenji Takeuchi, Yukie Shibata, Toru Takeshita, Fusanori Nishimura, Yoshihisa Yamashita

BIOMED RESEARCH INTERNATIONAL　2015　2015

DOI： 10.1155/2015/897971 　

ISSN： 2314-6133

eISSN： 2314-6141
Impact of Loss of Removable Dentures on Oral Health after the Great East Japan Earthquake: A Retrospective Cohort Study Peer-reviewed

Yukihiro Sato, Jun Aida, Kenji Takeuchi, Kanade Ito, Shihoko Koyama, Masako Kakizaki, Mari Sato, Ken Osaka, Ichiro Tsuji

JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY　24　(1)　32-36　2015/01

DOI： 10.1111/jopr.12210 　

ISSN： 1059-941X

eISSN： 1532-849X
Risk Factors for Reduced Salivary Flow Rate in a Japanese Population: The Hisayama Study Peer-reviewed

Kenji Takeuchi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Yoshihiro Shimazaki, Sumio Akifusa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita

BIOMED RESEARCH INTERNATIONAL　2015　2015

DOI： 10.1155/2015/381821 　

ISSN： 2314-6133

eISSN： 2314-6141
Inequalities of dental prosthesis use under universal healthcare insurance Peer-reviewed

Yusuke Matsuyama, Jun Aida, Kenji Takeuchi, Georgios Tsakos, Richard G. Watt, Katsunori Kondo, Ken Osaka

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY　42　(2)　122-128　2014/04

DOI： 10.1111/cdoe.12074 　

ISSN： 0301-5661

eISSN： 1600-0528
Nutritional status and dysphagia risk among community-dwelling frail older adults Peer-reviewed

K. Takeuchi, J. Aida, K. Ito, M. Furuta, Y. Yamashita, K. Osaka

JOURNAL OF NUTRITION HEALTH & AGING　18　(4)　352-357　2014/04

DOI： 10.1007/s12603-014-0025-3 　

ISSN： 1279-7707

eISSN： 1760-4788
Association between Periodontitis and Stroke : A Meta-analysis Based on Periodontal Measurement Characteristics Peer-reviewed

MATSUYAMA Yusuke, AIDA Jun, TAKEUCHI Kenji, ITO Kanade, NAKAYASU Mieko, KOYAMA Shihoko, HASE Akihiro, TSUBOYA Toru, OSAKA Ken

JOURNAL OF DENTAL HEALTH　64　(1)　2-9　2014
Publisher: Japanese Society for Oral Health
DOI： 10.5834/jdh.64.1_2 　

ISSN： 0023-2831

More details Close

From the year 2000, an increasing number of reports have focused on the association between periodontal and cardiovascular diseases. Periodontal measurements are carried out in a number of ways, and, therefore, the grading of periodontitis in each study may differ according to the measurements used. Some previous studies included meta-analyses; however, the heterogeneity of periodontal measurements was not taken into account. Therefore, we divided periodontal measurements which are taken more frequently into two groups: Group A, which included measurements reflecting inflammation on examination, as indicated by Bleeding on Probing (BOP) and Probing Pocket Depth (PPD); and Group B, which included measurements not reflecting inflammation on examination, indicated by Clinical Attachment Loss (CAL), and analyzed the pooled odds ratios (OR) of each group. We conducted online and manual searches, which revealed 688 articles, of which 11 fulfilled the inclusion criteria. The measurements in Group A did not reveal a significant correlation between periodontal and cerebrovascular diseases (OR = 1.35; 95% confidence interval [CI], 0.90-2.02), while Group B measurements revealed a significant positive correlation between the 2 diseases (OR = 1.96; 95% CI, 1.32-2.90). To assess the existence of publication bias, we drew funnel plots, which revealed the possibility of publication bias. In order to analyze non-published articles, a trim and fill method was used to assess Group B. After putative non-published articles were included in the analysis, a significant correlation was observed between periodontitis and cerebrovascular diseases (OR = 1.48; 95% CI, 1.07-2.06). Differences were observed between periodontitis and cerebrovascular disease due to different periodontal measurements. BOP and PPD cannot indicate the duration of periodontal disease, while CAL is a cumulative measure that can indicate the duration of periodontitis. Therefore, a stronger association may exist between CAL and cerebrovascular disease than that of BOP or PPD. This study suggests that the association between periodontal disease and stroke may differ according to periodontal measurements. Therefore, careful analysis is required while investigating the association between periodontal and cerebrovascular diseases, and further studies are warranted.
Social Participation and Dental Health Status among Older Japanese Adults: A Population-Based Cross-Sectional Study Peer-reviewed

Kenji Takeuchi, Jun Aida, Katsunori Kondo, Ken Osaka

PLOS ONE　8　(4)　2013/04

DOI： 10.1371/journal.pone.0061741 　

ISSN： 1932-6203
在宅高齢者の栄養状態と誤嚥リスクの把握

竹内研時, 相田潤, 伊藤奏, 小山史穂子, 吉中晋, 小坂健

日本摂食・嚥下リハビリテーション学会雑誌　16　(3)　S206-S206　2012/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
介護老人福祉施設における口腔機能維持管理加算と経口維持・移行加算の算定の現状

伊藤奏, 相田潤, 竹内研時, 小山史穂子, 小坂健

日本摂食・嚥下リハビリテーション学会雑誌　16　(3)　S396-S396　2012/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
Community-level socioeconomic status and parental smoking in Japan Peer-reviewed

Kenji Takeuchi, Jun Aida, Manabu Morita, Yuichi Ando, Ken Osaka

SOCIAL SCIENCE & MEDICINE　75　(4)　747-751　2012/08

DOI： 10.1016/j.socscimed.2012.04.001 　

ISSN： 0277-9536
都道府県歯科保健条例の記載事項の比較

竹内研時, 相田潤, 岩城倫弘, 田口千恵子, 田浦勝彦, 小林清吾, 小坂健

ヘルスサイエンス・ヘルスケア　11　(2)　72-77　2011/12
Publisher: 深井保健科学研究所
ISSN： 1881-1892

More details Close

2011年12月迄に、全国23道県で歯科保健条例が制定されている。各条例の特徴を調査し、記載事項を比較検討した。全ての条例で、健康の保持・増進、市町村との連携協力、歯科保健計画、障害者・要介護者への支援を記載していた。一方で、科学的根拠が存在し重要と考えられるフッ化物応用・洗口、喫煙対策、国と日本歯科医師会が主体となって進めている8020運動の記載がない条例が少なからず存在した。更に、口腔の健康格差是正にまで踏み込んで記載している条例は3県のみであった。今後条例を制定する地域においては、健康格差やフッ化物応用・洗口、喫煙対策といった項目も漏らさず記載する必要がある。

Show all ︎Show first 5

Misc. 201

公的統計における咀嚼に関連する食行動指標の概況と意義について

深井穫博, 大内章嗣, 福田英輝, 岡田寿朗, 佐々木健, 安藤雄一, 小川祐司, 竹内研時, 山中史教, 小畑充彦, 長優子, 田所大典, 皆川久美子, 江藤優希, 神原正樹, 宮崎秀夫, 嶋崎義浩, 花田信弘

口腔衛生学会雑誌　75　(1)　2025

ISSN： 0023-2831
歯科治療に対する支払い意欲に関連する要因の解明-日本老年学的評価研究(JAGES)

木内桜, 木内桜, 竹内研時, 草間太郎, 相田潤, 小坂健

日本歯科医師会雑誌　78　(4)　2025

ISSN： 0047-1763
歯科レセプトから把握する義歯使用状況の妥当性評価研究:LIFE Study

衣川安奈, 竹内研時, 玉田雄大, 草間太郎, 原田真奈実, 大野幸子, 前田恵, 村田典子, 小坂健, 福田治久

日本疫学会学術総会講演集(Web)　35th　2025
高齢者の住まいの暑さ・寒さとうつ傾向の関連:JAGES横断研究

岩田真歩, 竹内研時, 衣川安奈, 近藤克則, 花里真道, 小坂健

日本疫学会学術総会講演集(Web)　35th　2025
分割時系列解析を用いた生活保護認定による医療受診行動の変化の評価:LIFE Study

塩田千尋, 竹内研時, 竹内研時, 草間太郎, 玉田雄大, 前田恵, 村田典子, 小坂健, 福田治久

日本疫学会学術総会講演集(Web)　35th　2025
歯科保健を通じたwell-beingの向上を考えるコホート研究から探る健康寿命延伸に向けた口腔の健康の役割

竹内研時

日本全身咬合学会学術大会プログラム・抄録集　34回　17-17　2024/11
Publisher: (一社)日本全身咬合学会
2022年歯科疾患実態調査の解析作業報告および歯科疾患総量でみた推移の例示

深井穫博, 大内章嗣, 福田英輝, 岡田寿朗, 佐々木健, 安藤雄一, 小川祐司, 竹内研時, 山中史教, 小畑充彦, 長優子, 田所大典, 皆川久美子, 江藤優希, 神原正樹, 宮崎秀夫, 嶋崎義浩, 花田信弘, 日本口腔衛生学会・地域口腔保健委員会(2023年-2024年)

口腔衛生学会雑誌　74　(4)　309-313　2024/10
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯科インプラント治療後の心理的変化に関する質問紙調査研究

伊藤明日香, 花渕静, 小川徹, 竹内研時, 佐藤由美子, 石井京子, 小野寺芽美, 渡部千代, 佐々木啓一, 依田信裕

日本歯科衛生学会雑誌　19　(1)　117-117　2024/08
Publisher: 日本歯科衛生学会
ISSN： 1884-5193
生活保護受給開始前後での医科・歯科医療費の変化 LIFE Study

塩田千尋, 竹内研時, 玉田雄大, 草間太郎, 福田治久, 小坂健

口腔衛生学会雑誌　74　(増刊)　112-112　2024/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯周病と新規糖尿病発症の併存と年間医療費との関連 LIFE Study

衣川安奈, 竹内研時, 玉田雄大, 草間太郎, 佐藤美寿々, 福田治久, 小坂健

口腔衛生学会雑誌　74　(増刊)　122-122　2024/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯の本数と認知症を有さない余命期間との関連 JAGESコホート研究

木内桜, 松山祐輔, 竹内研時, 草間太郎, 小坂健, 相田潤

口腔衛生学会雑誌　74　(増刊)　122-122　2024/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
成人集団における喪失歯数とHuman Flourishingとの関連 JACSIS横断研究

青山高弘, 衣川安奈, 竹内研時, 草間太郎, 玉田雄大, 塩田千尋, 小坂健

口腔衛生学会雑誌　74　(増刊)　162-162　2024/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
在宅勤務経験の有無と口腔疾患との関連 JACSIS2022横断研究

和田健太郎, 塩田千尋, 竹内研時, 草間太郎, 玉田雄大, 衣川安奈, 小坂健

口腔衛生学会雑誌　74　(増刊)　162-162　2024/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
抑うつ傾向と歯磨き回数との関連 JAC-SIS2022横断研究

白田和慧, 塩田千尋, 竹内研時, 草間太郎, 玉田雄大, 衣川安奈, 小坂健

口腔衛生学会雑誌　74　(増刊)　163-163　2024/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
新型コロナウイルス2価ワクチン有効性の経時的変化 VENUS Study

玉田雄大, 塩田千尋, 竹内研時, 小坂健, 前田恵, 村田典子, 福田治久

日本衛生学雑誌　79　(Suppl.)　S225-S225　2024/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082

eISSN： 1882-6482
支持政党と新型コロナワクチン接種に対する忌避との関連 JASTIS2022横断研究

草間太郎, 玉田雄大, 塩田千尋, 竹内研時, 小坂健, 田淵貴大

日本衛生学雑誌　79　(Suppl.)　S225-S225　2024/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082

eISSN： 1882-6482
食育における歯科口腔保健の推進のための研究種々の統計データを用いた分析(政府統計)

山本貴文, 衣川安奈, 小坂健, 竹内研時, 草間太郎

食育における歯科口腔保健の推進のための研究令和5年度総括・分担研究報告書(Web)　2024
成育基本法を地域格差なく継続的に社会実装するための研究学校におけるフッ化物洗口とう蝕の治療費に関する研究

相田潤, 田所大典, 本田和枝, 小坂健, 竹内研時, 草間太郎, 島田怜実

成育基本法を地域格差なく継続的に社会実装するための研究令和5年度総括・分担研究報告書(Web)　2024
タバコ製品の使用状況の変化による重度歯周病移行リスクの違い:JACSIS研究

塩田千尋, 竹内研時, 竹内研時, 玉田雄大, 玉田雄大, 草間太郎, 草間太郎, 小坂健, 田淵貴大

日本公衆衛生学会総会抄録集(CD-ROM)　83rd　2024
心理的ストレスの強さ、立ち直りの速さ、SOCと高血圧有病との関連 J-MICC研究(静岡地区)

永吉真子, 菱田朝陽, 吉岡曉子, 都築陽祐, 竹内研時, 加藤泰文, 久保陽子, 岡田理恵子, 田村高志, 玉田雄大, 森厚嘉, 若井建志

Journal of Epidemiology　34　(Suppl.)　176-176　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
加熱式タバコを含むタバコ製品の使用と歯周病発症リスクとの関連の検討

塩田千尋, 竹内研時, 草間太郎, 木内桜, 玉田雄大, 小坂健, 田淵貴大

日本公衆衛生学会総会抄録集　82回　297-297　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Test-negative designによる新型コロナウイルス2価ワクチンの有効性評価 VENUS Study

玉田雄大, 竹内研時, 草間太郎, 小坂健, 前田恵, 村田典子, 福田治久

日本公衆衛生学会総会抄録集　82回　326-326　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
地域住民コホート調査によるメタボロームと認知機能低下の関連

木内桜, 中谷久美, 竹内研時, 小坂健, 寳澤篤

日本公衆衛生学会総会抄録集　82回　389-389　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
行政歯科衛生士のキャリアラダー及び研修体系構築の課題と展望

小栗智江子, 高澤みどり, 竹内研時, 犬飼順子, 古川大祐, 長谷川勢子, 澁谷いづみ

日本公衆衛生学会総会抄録集　82回　500-500　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高齢者における緑茶摂取と主観的な口腔健康状態との関連横断研究より

野口有紀, 藤田美枝子, 種村崇, 竹内研時, 吉田直樹

東海公衆衛生雑誌　11　(1)　65-70　2023/07
Publisher: 東海公衆衛生学会
ISSN： 2187-736X

eISSN： 2434-0421
地域歯科口腔保健事業の連携状況に関する調査報告

深井穫博, 大内章嗣, 福田英輝, 岡田寿朗, 佐々木健, 安藤雄一, 小川祐司, 竹内研時, 山中史教, 小畑充彦, 長優子, 田所大典, 皆川久美子, 日本口腔衛生学会地域口腔保健委員会

口腔衛生学会雑誌　73　(2)　122-125　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯科口腔保健医療のエビデンスと政策を考える歯科口腔保健の医療経済的エビデンス

竹内研時

口腔衛生学会雑誌　73　(増刊)　110-110　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯科受診の有無と8年間の累積介護費用との関連 JAGESコホート研究

木内桜, 竹内研時, 草間太郎, 中澤典子, 相田潤, 小坂健, 近藤克則, 斉藤雅茂

口腔衛生学会雑誌　73　(増刊)　142-142　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
オーラルフレイルの地域差と地域差に関連する要因横断研究

持田悠貴, 山本龍生, 入江浩一郎, 渕田慎也, Altanbagana Nandin Uchral, 相田潤, 竹内研時, 藤田美枝子, 近藤克則

口腔衛生学会雑誌　73　(増刊)　159-159　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
労働者におけるVisual Display Terminals時間と歯痛との関連 JACSIS研究

村松賢志郎, 塩田千尋, 竹内研時, 草間太郎, 木内桜, 中澤典子, 小坂健

口腔衛生学会雑誌　73　(増刊)　165-165　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
良好な職場環境と予防目的の歯科受診との関連 JACSIS研究

劉芳吟, 竹内研時, 草間太郎, 木内桜, 中澤典子, 塩田千尋, 小坂健

口腔衛生学会雑誌　73　(増刊)　166-166　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
新型コロナウイルス流行下における帰宅時のうがい習慣と味覚・嗅覚障害との関連の検討 JASTIS研究

大内博貴, 中澤典子, 竹内研時, 草間太郎, 木内桜, 塩田千尋, 小坂健

口腔衛生学会雑誌　73　(増刊)　173-173　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
高齢者の日常生活における笑いの頻度と抑うつ状態の関連 JAGES縦断研究

岡崎愛, 竹内研時, 草間太郎, 木内桜, 小坂健

口腔衛生学会雑誌　73　(増刊)　176-176　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
ストロング系アルコール飲料の摂取習慣と歯周病との関連 JACSIS研究

佐藤那紀, 竹内研時, 草間太郎, 木内桜, 中澤典子, 塩田千尋, 小坂健

口腔衛生学会雑誌　73　(増刊)　182-182　2023/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
高齢者におけるインターネット利用と現在歯との関連

野口有紀, 藤田美枝子, 藤田美枝子, 上田一紀, 種村崇, 竹内研時, 吉田直樹

口腔衛生学会雑誌　73　2023

ISSN： 0023-2831
笑いの健康効果に関する近年の研究動向笑いを増やすための口腔からのアプローチを考える

竹内研時

歯界展望　140　(6)　1065-1068　2022/12
Publisher: 医歯薬出版
ISSN： 0011-8702
歯科口腔保健の新時代データからのat a glance(第10回) 予防効果を把握し最大化するためのアプローチ

竹内研時

歯界展望　140　(1)　144-147　2022/07
Publisher: 医歯薬出版(株)
ISSN： 0011-8702
WHOの口腔保健の決議を受けて:学術的視点から考えるフッ化物応用医療経済的側面からみたフッ化物洗口

竹内研時

口腔衛生学会雑誌　72　(増刊)　37-38　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
新型コロナウイルス感染症拡大期の対面交流と笑いの頻度との関連

木内桜, 竹内研時, 草間太郎, 小坂健

口腔衛生学会雑誌　72　(増刊)　86-86　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯の喪失による死亡リスク上昇における体重減少の媒介効果高齢者を対象としたJAGESコホート研究

草間太郎, 竹内研時, 木内桜, 相田潤, 近藤克則, 小坂健

口腔衛生学会雑誌　72　(増刊)　93-93　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
前期高齢者におけるインターネット利用と歯間部補助用具の使用との関連

野口有紀, 藤田美枝子, 種村崇, 吉田直樹, 竹内研時

口腔衛生学会雑誌　72　(増刊)　94-94　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
舌苔細菌叢の加齢変化とその特徴の探索

朝川美加李, 竹下徹, 影山伸哉, 古田美智子, 竹内研時, 須磨紫乃, 山下喜久

口腔衛生学会雑誌　72　(増刊)　110-110　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
生活習慣病対策における歯科口腔保健のあり方特定健診・標準的質問票に咀嚼に関する質問が組み込まれたことを踏まえて

深井穫博, 大内章嗣, 福田英輝, 岡田寿朗, 佐々木健, 安藤雄一, 小川祐司, 竹内研時, 山中史教, 小畑充彦, 長優子, 田所大典, 皆川久美子, 神原正樹, 宮崎秀夫, 嶋崎義浩, 花田信弘, 日本口腔衛生学会地域口腔保健委員会

口腔衛生学会雑誌　72　(2)　122-129　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
WHOの口腔保健の決議を受けて:学術的視点から考えるフッ化物応用医療経済的側面からみたフッ化物洗口

竹内研時

口腔衛生学会雑誌　72　(増刊)　37-38　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
新型コロナウイルス感染症拡大期の対面交流と笑いの頻度との関連

木内桜, 竹内研時, 草間太郎, 小坂健

口腔衛生学会雑誌　72　(増刊)　86-86　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯の喪失による死亡リスク上昇における体重減少の媒介効果高齢者を対象としたJAGESコホート研究

草間太郎, 竹内研時, 木内桜, 相田潤, 近藤克則, 小坂健

口腔衛生学会雑誌　72　(増刊)　93-93　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
前期高齢者におけるインターネット利用と歯間部補助用具の使用との関連

野口有紀, 藤田美枝子, 種村崇, 吉田直樹, 竹内研時

口腔衛生学会雑誌　72　(増刊)　94-94　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
舌苔細菌叢の加齢変化とその特徴の探索

朝川美加李, 竹下徹, 影山伸哉, 古田美智子, 竹内研時, 須磨紫乃, 山下喜久

口腔衛生学会雑誌　72　(増刊)　110-110　2022/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
Relationship between Caregivers’ and Children’s Self-rated Oral Health-Exploratory Research-

野口有紀, 吉田直樹, 藤田美枝子, 竹内研時

社会歯科学会雑誌　14　(2)　2022

ISSN： 2434-2084
地域在住成人における食品群摂取量と高感度CRPとの関連の横断的検討

松永貴史, 今枝奈保美, 今枝奈保美, 後藤千穂, 後藤千穂, 玉田雄大, 加藤泰文, 久保陽子, 岡田理恵子, 永吉真子, 田村高志, 菱田朝陽, 竹内研時, 若井建志

日本疫学会学術総会講演集(Web)　32nd　2022
地域在住高齢者における現在歯数および食習慣フレイルとの関連についての横断研究

宮野貴士, 金子諒右, 加藤幸一郎, 岸村顕広, 片山佳樹, 古田美智子, 木村年秀, 丸岡三紗, 竹内研時, 須磨紫乃, 岡田寿朗, 豊嶋健治, 山下喜久

Journal of Epidemiology　32　(Suppl.1)　150-150　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
20歯未満の地域在住高齢者において低栄養と関連する因子を探索する横断研究

金子諒右, 宮野貴士, 岸村顕広, 加藤幸一郎, 片山佳樹, 古田美智子, 木村年秀, 丸岡三紗, 竹内研時, 須磨紫乃, 岡田寿朗, 豊嶋健治, 山下喜久

Journal of Epidemiology　32　(Suppl.1)　150-150　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
自立高齢者における関節リウマチの診断とフレイル、社会的背景に関する検討 JAGES横断研究

小嶋雅代, 渡邉良太, 安岡実佳子, 竹内研時, 斎藤民, 寺部健哉, 小嶋俊久, 尾島俊之, 武藤剛, 大関沙依, 近藤克則

Journal of Epidemiology　32　(Suppl.1)　152-152　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
PAPSS1遺伝子多型と肝機能異常との関連

藤和太, 内藤真理子, 塚本峰子, 門松由佳, 久保陽子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 竹内研時, 若井建志, 浜島信之

Journal of Epidemiology　32　(Suppl.1)　156-156　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
日本人コホート集団30,685人を対象とした腎性低尿酸血症の臨床遺伝疫学的解析実際的診断に向けて

河村優輔, 中山昌喜, 豊田優, 西田裕一郎, 菱田朝陽, 釜野桜子, 渋谷謙一, 田村高志, 中島宏, 指宿りえ, 上村浩一, 原めぐみ, 竹内研時, 角田正史, 有澤幸吉, 嶽崎俊郎, 田中恵太郎, 若井建志, 四ノ宮成祥, 松尾洋孝

Journal of Epidemiology　32　(Suppl.1)　157-157　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
高齢者の日常生活における笑いとフレイル発生リスクとの関連 JAGES縦断研究

玉田雄大, 竹内研時, 斉藤雅茂, 山口知香枝, 白井こころ, 大平哲也, 小嶋雅代, 若井建志, 近藤克則

Journal of Epidemiology　32　(Suppl.1)　148-148　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
地域在住高齢者における現在歯数および食習慣フレイルとの関連についての横断研究

宮野貴士, 金子諒右, 加藤幸一郎, 岸村顕広, 片山佳樹, 古田美智子, 木村年秀, 丸岡三紗, 竹内研時, 須磨紫乃, 岡田寿朗, 豊嶋健治, 山下喜久

Journal of Epidemiology　32　(Suppl.1)　150-150　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
20歯未満の地域在住高齢者において低栄養と関連する因子を探索する横断研究

金子諒右, 宮野貴士, 岸村顕広, 加藤幸一郎, 片山佳樹, 古田美智子, 木村年秀, 丸岡三紗, 竹内研時, 須磨紫乃, 岡田寿朗, 豊嶋健治, 山下喜久

Journal of Epidemiology　32　(Suppl.1)　150-150　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
自立高齢者における関節リウマチの診断とフレイル、社会的背景に関する検討 JAGES横断研究

小嶋雅代, 渡邉良太, 安岡実佳子, 竹内研時, 斎藤民, 寺部健哉, 小嶋俊久, 尾島俊之, 武藤剛, 大関沙依, 近藤克則

Journal of Epidemiology　32　(Suppl.1)　152-152　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
PAPSS1遺伝子多型と肝機能異常との関連

藤和太, 内藤真理子, 塚本峰子, 門松由佳, 久保陽子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 竹内研時, 若井建志, 浜島信之

Journal of Epidemiology　32　(Suppl.1)　156-156　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
日本人コホート集団30,685人を対象とした腎性低尿酸血症の臨床遺伝疫学的解析実際的診断に向けて

河村優輔, 中山昌喜, 豊田優, 西田裕一郎, 菱田朝陽, 釜野桜子, 渋谷謙一, 田村高志, 中島宏, 指宿りえ, 上村浩一, 原めぐみ, 竹内研時, 角田正史, 有澤幸吉, 嶽崎俊郎, 田中恵太郎, 若井建志, 四ノ宮成祥, 松尾洋孝

Journal of Epidemiology　32　(Suppl.1)　157-157　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
尿中尿酸排泄率と血清尿酸値の特徴的な分布パターンに基づく腎性低尿酸血症の実践的な診断モデルの提案日本人30685人を対象とした臨床遺伝疫学的解析より

河村優輔, 中山昌喜, 豊田優, 川口真, 高田雄三, 清水聖子, 高田龍平, 市田公美, 四ノ宮成祥, 松尾洋孝, 西田裕一郎, 原めぐみ, 田中恵太郎, 渋谷謙一, 指宿りえ, 嶽崎俊郎, 釜野桜子, 有澤幸吉, 上村浩一, 菱田朝陽, 田村高志, 竹内研時, 若井建志, 鈴木聡子, 岩澤聡子, 中島宏, 角田正史

日本痛風・尿酸核酸学会総会プログラム・抄録集　55回　66-66　2022/01
Publisher: (一社)日本痛風・尿酸核酸学会
URAT1遺伝子の機能低下型変異による痛風の保護効果は、ABCG2遺伝子の機能低下型変異による痛風のリスク亢進効果を上回る

豊田優, 河村優輔, 中山昌喜, 東野俊英, 清水聖子, 大山博司, 市田公美, 四ノ宮成祥, 高田龍平, 松尾洋孝, 中岡博史, 竹内研時, 井ノ上逸郎, 鈴木洋史

日本痛風・尿酸核酸学会総会プログラム・抄録集　55回　69-69　2022/01
Publisher: (一社)日本痛風・尿酸核酸学会
歯科健診における歯周病判定と糖尿病発生の関連性 LIFE Study

谷直道, 竹内研時, 福田治久

日本公衆衛生学会総会抄録集　80回　434-434　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
コロナ禍における歯磨き及び集団フッ化物洗口等の実施状況報告

田所大典, 相田潤, 草間太郎, 井下英二, 竹内研時, 濃野要, 松山祐輔, 三宅達郎, 小坂健

日本公衆衛生学会総会抄録集　80回　437-437　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
後ろ向きコホート研究におけるメタボリックシンドロームの発症と現在歯数との関連

須磨紫乃, 古田美智子, 竹内研時, 山下喜久

日本歯科医師会雑誌　74　(4)　407-407　2021/07
Publisher: (公社)日本歯科医師会
ISSN： 0047-1763
ニホンコウコウエイセイガッカイガッカイセイメイ『ショウガイ 28 』ノカガクテキコンキョニツイテカンガエル

137　(4)　887-891　2021/04
Publisher: 医歯薬出版
ISSN： 0011-8702
口腔衛生・予防歯科研究の新たな展開-その専門性を問う- 歯科医師兼疫学者がライフワークとする研究を見つけるために

竹内研時

口腔衛生学会雑誌　71　(増刊)　55-55　2021/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域住民における発酵乳製品の摂取と歯の喪失の関係

古田美智子, 竹内研時, 竹下徹, 須磨紫乃, 影山伸哉, 朝川美加李, 嶋崎義浩, 二宮利治, 山下喜久, 内田和宏

口腔衛生学会雑誌　71　(増刊)　86-86　2021/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
12歳男児の主観的口腔健康感と養育者の主観的口腔健康感との関連

野口有紀, 藤田美枝子, 吉田直樹, 竹内研時

口腔衛生学会雑誌　71　(増刊)　99-99　2021/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
人口10万人対歯科医師数を横軸スケールとした都道府県別歯科医師人口ピラミッドの作成

安藤雄一, 福田英輝, 田野ルミ, 竹内研時, 大島克郎, 大内章嗣

口腔衛生学会雑誌　71　(増刊)　108-108　2021/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
『生涯28』の科学的根拠について考える歯の喪失の歯科・医科医療費への影響

竹内研時

歯界展望　137　(4)　887-891　2021/04
Publisher: 医歯薬出版(株)
ISSN： 0011-8702
口腔衛生・予防歯科研究の新たな展開-その専門性を問う- 歯科医師兼疫学者がライフワークとする研究を見つけるために

竹内研時

口腔衛生学会雑誌　71　(増刊)　55-55　2021/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域住民における発酵乳製品の摂取と歯の喪失の関係

古田美智子, 竹内研時, 竹下徹, 須磨紫乃, 影山伸哉, 朝川美加李, 嶋崎義浩, 二宮利治, 山下喜久, 内田和宏

口腔衛生学会雑誌　71　(増刊)　86-86　2021/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
12歳男児の主観的口腔健康感と養育者の主観的口腔健康感との関連

野口有紀, 藤田美枝子, 吉田直樹, 竹内研時

口腔衛生学会雑誌　71　(増刊)　99-99　2021/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
人口10万人対歯科医師数を横軸スケールとした都道府県別歯科医師人口ピラミッドの作成

安藤雄一, 福田英輝, 田野ルミ, 竹内研時, 大島克郎, 大内章嗣

口腔衛生学会雑誌　71　(増刊)　108-108　2021/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
withコロナの口腔予防管理

山下喜久, 須磨紫乃, 古田美智子, 竹内研時

歯界展望　137　(3)　669-673　2021/03
Publisher: 医歯薬出版(株)
ISSN： 0011-8702
PAPSS1遺伝子多型と空腹時血糖値との関連

藤和太, 内藤真理子, 塚本峰子, 門松由佳, 久保陽子, 岡田理恵子, 永吉真子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 竹内研時, 若井建志, 浜島信之

Journal of Epidemiology　31　(Suppl.)　136-136　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
口とこころ口腔と精神保健口腔保健から考える認知症予防

竹内研時

口腔衛生学会雑誌　71　(1)　51-51　2021/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
新型コロナウイルス感染症緊急事態宣言期間における在宅勤務と座位時間延長との関連

竹内研時, 小山晃英, 玉田雄大, 田淵貴大

Journal of Epidemiology　31　(Suppl.)　91-91　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
炭水化物・脂質摂取量と全死亡との関連日本多施設共同コーホート研究(J-MICC Study)

田村高志, 門松由佳, 塚本峰子, 久保陽子, 岡田理恵子, 永吉真子, 菱田朝陽, 竹内研時, 若井建志

Journal of Epidemiology　31　(Suppl.)　95-95　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
ストレス対処行動とがん死亡リスクとの関係 J-MICC Study

永吉真子, 塚本峰子, 久保陽子, 岡田理恵子, 田村高志, 菱田朝陽, 竹内研時, 若井建志

Journal of Epidemiology　31　(Suppl.)　115-115　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
精神的健康度とストレス対処行動との関連

塚本峰子, 久保陽子, 永吉真子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 竹内研時, 若井建志

Journal of Epidemiology　31　(Suppl.)　122-122　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
緊急事態宣言期間の歯科医院の状況と国民の歯科受診行動

竹内研時

ヘルスサイエンス・ヘルスケア　20　(2)　23-26　2020/12
Publisher: 深井保健科学研究所
ISSN： 1881-1892
緊急事態宣言期間の歯科医院の状況と国民の歯科受診行動

竹内研時

ヘルスサイエンス・ヘルスケア　20　(2)　23-26　2020/12
Publisher: 深井保健科学研究所
ISSN： 1881-1892
社会参加とフレイル関節リウマチ患者と「健康とくらしの調査2016」参加者との比較

小嶋雅代, 上地香杜, 安岡実佳子, 武藤剛, 飯塚玄明, 斎藤民, 渡邉美貴, 鈴木貞夫, 竹内研時, 若井建志, 尾島俊之, 近藤克則

日本公衆衛生学会総会抄録集　79回　250-250　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
フレイル状態にある関節リウマチ患者と地域在住高齢者の比較検討

上地香杜, 小嶋雅代, 安岡実佳子, 武藤剛, 飯塚玄明, 斎藤民, 渡邉美貴, 鈴木貞夫, 竹内研時, 若井建志, 尾島俊之, 近藤克則

日本公衆衛生学会総会抄録集　79回　250-250　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高齢者サロンへの参加状況と味覚・舌圧との関連

永吉真子, 玉井慎美, 延末謙一, 本多由起子, 竹内研時, 若井建志, 前田隆浩

日本公衆衛生学会総会抄録集　79回　253-253　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
都道府県別にみた歯科医師の人口ピラミッドから見える歯科医師供給の将来像

安藤雄一, 福田英輝, 田野ルミ, 竹内研時, 大島克郎

日本公衆衛生学会総会抄録集　79回　419-419　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
社会参加とフレイル関節リウマチ患者と「健康とくらしの調査2016」参加者との比較

小嶋雅代, 上地香杜, 安岡実佳子, 武藤剛, 飯塚玄明, 斎藤民, 渡邉美貴, 鈴木貞夫, 竹内研時, 若井建志, 尾島俊之, 近藤克則

日本公衆衛生学会総会抄録集　79回　250-250　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
フレイル状態にある関節リウマチ患者と地域在住高齢者の比較検討

上地香杜, 小嶋雅代, 安岡実佳子, 武藤剛, 飯塚玄明, 斎藤民, 渡邉美貴, 鈴木貞夫, 竹内研時, 若井建志, 尾島俊之, 近藤克則

日本公衆衛生学会総会抄録集　79回　250-250　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高齢者サロンへの参加状況と味覚・舌圧との関連

永吉真子, 玉井慎美, 延末謙一, 本多由起子, 竹内研時, 若井建志, 前田隆浩

日本公衆衛生学会総会抄録集　79回　253-253　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
都道府県別にみた歯科医師の人口ピラミッドから見える歯科医師供給の将来像

安藤雄一, 福田英輝, 田野ルミ, 竹内研時, 大島克郎

日本公衆衛生学会総会抄録集　79回　419-419　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
成人における主観的な口腔健康状態と自殺を考えた経験との関連

野口有紀, 藤田美枝子, 竹内研時

日本歯科衛生学会雑誌　15　(1)　34-44　2020/08
Publisher: 日本歯科衛生学会
ISSN： 1884-5193
中学生のインターネット利用時間とう蝕経験の関連の検討

藤田美枝子, 野口有紀, 森下綾香, 松本美奈子, 松浦知佐子, 竹内研時

日本歯科衛生学会雑誌　15　(1)　68-68　2020/08
Publisher: 日本歯科衛生学会
ISSN： 1884-5193
壮年期における口腔健康状態と緑茶摂取との関連

野口有紀, 藤田美枝子, 竹内研時

日本歯科衛生学会雑誌　15　(1)　74-74　2020/08
Publisher: 日本歯科衛生学会
ISSN： 1884-5193
新型コロナウイルス感染拡大下における一般住民の歯科医院受診に関する意識調査

高屋翔, 小山史穂子, 竹内研時

The Quintessence　39　(7)　1588-1593　2020/07
Publisher: クインテッセンス出版(株)
ISSN： 0286-407X
COVID-19感染拡大下における歯科受診行動どんな人が歯科受診に不安を抱いているのか

小山史穂子, 竹内研時

口腔衛生学会雑誌　70　(3)　168-174　2020/07
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
小学校でのフッ化物洗口の経験と成人のう蝕との関係

古田美智子, 竹内研時, 竹下徹, 須磨紫乃, 影山伸哉, 朝川美加李, 奥菜央理, 黒江慧, 高尾直宏, 柴田幸江, 二宮利治, 山下喜久

口腔衛生学会雑誌　70　(2)　106-106　2020/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
「生涯28」の科学的根拠について考える歯の喪失の歯科・医科医療費への影響

竹内研時

口腔衛生学会雑誌　70　(増刊)　68-68　2020/03
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
成人における口腔の健康状態とインターネット活用による健康情報の入手との関連

野口有紀, 竹内研時, 藁科穂奈美, 藤田美枝子, 仲井雪絵

口腔衛生学会雑誌　70　(増刊)　112-112　2020/03
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
「生涯28」の科学的根拠について考える歯の喪失の歯科・医科医療費への影響

竹内研時

口腔衛生学会雑誌　70　(増刊)　68-68　2020/03
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
成人における口腔の健康状態とインターネット活用による健康情報の入手との関連

野口有紀, 竹内研時, 藁科穂奈美, 藤田美枝子, 仲井雪絵

口腔衛生学会雑誌　70　(増刊)　112-112　2020/03
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
メタボリックシンドロームの発症と現在歯数および摂食速度との関連

須磨紫乃, 古田美智子, 竹内研時, 山下喜久

口腔衛生学会雑誌　70　(増刊)　114-114　2020/03
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域住民の口腔の健康状態の経年的変化と歯科疾患実態調査との比較

古田美智子, 竹内研時, 竹下徹, 須磨紫乃, 影山伸哉, 朝川美加李, 黒江慧, 柴田幸江, 嶋崎義浩, 二宮利治, 山下喜久

口腔衛生学会雑誌　70　(増刊)　117-117　2020/03
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
消化管がん患者の唾液マイクロバイオームに特徴的な細菌種の同定

影山伸哉, 竹下徹, 竹内研時, 朝川美加李, 古田美智子, 柴田幸江, 山下喜久, 永井清志, 池部正彦, 森田勝, 益田宗幸, 藤也寸志, 清原裕, 二宮利治

口腔衛生学会雑誌　70　(増刊)　149-149　2020/03
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
高齢者の低栄養に関する社会的要因について

古田美智子, 木村年秀, 丸岡三沙, 竹内研時, 竹内研時, 須磨紫乃, 岡田寿朗, 豊嶋健治, 山下喜久

日本疫学会学術総会講演集(Web)　30th　2020
高齢者の口腔機能と死亡との関係に関する地域疫学研究-日常の生活環境と習慣(人とのつながり・発声頻度・咀嚼)は予後に影響を与えるか-

永吉真子, 竹内研時, 前田隆浩

8020公募研究報告書抄録(Web)　2020　2020
一人で/誰かと笑うかで要介護リスクは異なるか:JAGES縦断研究

山口知香枝, 竹内研時, 玉田雄大, 白井こころ, 大平哲也, 斉藤雅茂, 近藤克則, 近藤克則

日本疫学会学術総会講演集(Web)　30th　2020
地域住民における歯の喪失と認知症発症との関連久山町研究

竹内研時

口腔衛生学会雑誌　70　(1)　7-10　2020/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831

More details Close

地域在住の一般高齢住民を対象とした前向きコホートデータをもとに、歯の喪失が認知症発症に及ぼす影響を病型別に検討した。2007〜2008年に福岡県久山町の住民健診を受診した60歳以上の高齢男女1566名(男性691名、女性875名)を解析対象とした。追跡期間(中央値5.3年)中に180名が認知症を発症し、病型別ではアルツハイマー病(AD)が127名、血管性認知症が42名であった。全認知症発症の調整ハザード比は20歯以上群に比べて10〜19歯群1.62、1〜9歯群1.81、0歯群1.63と現在歯数の減少に伴い有意に増加した。病型別でみた場合、AD発症の調整ハザード比も現在歯数の減少に伴い増加する傾向にあった。一方、血管性認知症発症と現在歯数の減少との間には有意な関係は認められなかったものの、20歯以上群に比べて10〜19歯群の血管性認知症発症の調整ハザード比は3.19と有意に高いことが確認された。
口腔健康状態と自殺願望との関連

野口有紀, 藁科穂奈美, 竹内研時, 仲井雪絵

日本歯科衛生学会雑誌　14　(1)　161-161　2019/08
Publisher: 日本歯科衛生学会
ISSN： 1884-5193
歯科衛生士等による定期的なう蝕予防の情報提供が中学生の歯科保健行動に及ぼす効果の検討

藤田美枝子, 野口有紀, 竹内研時, 仲井雪絵

日本歯科衛生学会雑誌　14　(1)　176-176　2019/08
Publisher: 日本歯科衛生学会
ISSN： 1884-5193
歯周状態と肝機能の関連性について

黒江慧, 古田美智子, 竹内研時, 田中照彦, 須磨紫乃, 竹下徹, 品川隆, 山下喜久

口腔衛生学会雑誌　69　(3)　154-154　2019/07
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域高齢者における歯の損失と認知症の危険性久山研究(Tooth Loss and Risk of Dementia in the Community: the Hisayama Study)

竹内研時

口腔衛生学会雑誌　69　(増刊)　60-60　2019/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域歯科保健人材養成プログラムの概要と今後の在り方-口腔衛生学会専門医の創設を見据えて- 地域歯科保健を支える歯科医師・研究者に求められる知識・技能と課題(大学・研究者の立場から)

竹内研時

口腔衛生学会雑誌　69　(増刊)　83-84　2019/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯周組織状態と糖尿病発症との関係

古田美智子, 竹内研時, 竹下徹, 須磨紫乃, 品川隆, 嶋崎義浩, 山下喜久

口腔衛生学会雑誌　69　(増刊)　163-163　2019/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯周組織状態と非ウイルス性の肝線維化の関連性について

黒江慧, 古田美智子, 竹内研時, 田中照彦, 須磨紫乃, 竹下徹, 嶋崎義浩, 品川隆, 山下喜久

口腔衛生学会雑誌　69　(増刊)　164-164　2019/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
施設入所高齢者における義歯利用と肺炎発症の関連

竹内研時, 泉繭依, 古田美智子, 竹下徹, 柴田幸江, 影山伸哉, 岡部優花, 秋房住郎, 我那覇生純

日本疫学会学術総会講演集(Web)　29th　2019
誤嚥性肺炎予防における舌清掃を加えた口腔ケアが咳嗽力の維持・改善に与える影響の検討

泉繭依, 竹内研時, 秋房住郎, 我那覇生純, 山下喜久

日本口腔ケア学会雑誌　12　(3)　162-162　2018/04
Publisher: (一社)日本口腔ケア学会
ISSN： 1881-9141
施設入所高齢者における舌苔マイクロバイオームと肺炎死亡の関連

影山伸哉, 竹下徹, 古田美智子, 冨岡未記子, 朝川美加李, 須磨紫乃, 竹内研時, 柴田幸江, 岩佐康行, 山下喜久

日本口腔ケア学会雑誌　12　(3)　162-162　2018/04
Publisher: (一社)日本口腔ケア学会
ISSN： 1881-9141
メタボリックシンドロームの発症と歯科健診受診との関連:5年間の後ろ向きコホート研究

田中照彦, 竹内研時, 古田美智子, 須磨紫乃, 竹下徹, 嶋崎義浩, 品川隆, 山下喜久

口腔衛生学会雑誌　68　(増刊)　111-111　2018/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域在住高齢者における咀嚼機能と低栄養の関連性の男女差の検討

須磨紫乃, 古田美智子, 竹内研時, 竹下徹, 竹下徹, 柴田幸江, 嶋崎義浩, 二宮利治, 山下喜久

口腔衛生学会雑誌　68　(増刊)　163-163　2018/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
かかりつけ歯科医の性別による患者の歯科保健行動の違い

竹内研時, 野口有紀, 山下喜久

口腔衛生学会雑誌　68　(増刊)　122-122　2018/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
施設高齢者における現在歯数に関連する因子の検討

岩佐康行, 須磨紫乃, 古田美智子, 竹内研時, 山下喜久

口腔衛生学会雑誌　68　(増刊)　166-166　2018/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域一般住民における呼吸機能低下に及ぼす歯周病の影響の解析久山町研究

福山聡, 松元幸一郎, 竹内研時, 緒方大聡, 竹下徹, 古田美智子, 須磨紫乃, 秦淳, 二宮利治, 山下喜久, 井上博雅, 中西洋一

日本呼吸器学会誌　7　(増刊)　255-255　2018/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
舌苔細菌叢の構成と高齢者の肺炎死亡リスクとの関連

竹下徹, 影山伸哉, 須磨紫乃, 古田美智子, 竹内研時, 朝川美加李, 岩佐康行, 山下喜久

日本嫌気性菌感染症学会雑誌　48　(1)　37-37　2018/03
Publisher: 日本嫌気性菌感染症学会
ISSN： 2188-7365
地域一般住民における呼吸機能低下に及ぼす歯周病の影響の解析久山町研究

福山聡, 松元幸一郎, 竹内研時, 緒方大聡, 竹下徹, 古田美智子, 須磨紫乃, 秦淳, 二宮利治, 山下喜久, 井上博雅, 中西洋一

日本呼吸器学会誌　7　(増刊)　255-255　2018/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876
九州・沖縄地方における集団応用フッ化物洗口普及の推移(第2報) 県別の実施市町村の割合、施設別の実施状況と公的支援状況について

田浦勝彦, 晴佐久悟, 古田美智子, 竹内研時, 井上文子, 岩瀬達雄, 重政昭彦, 市野浩司, 難波亮二, 森木大輔, 加藤進作, 木本一成, 筒井昭仁, 境脩, 山内皓央

口腔衛生学会雑誌　68　(1)　45-46　2018/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域一般住民における呼吸機能低下に及ぼす歯周病の影響の検討

竹内研時, 古田美智子, 須磨紫乃, 秦淳, 二宮利治, 山下喜久, 松元幸一郎, 福山聡, 緒方大聡

日本公衆衛生学会総会抄録集　76回　447-447　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
農山村地域における地縁的な活動への参加と主観的健康感との関連

野口有紀, 伊藤奏, 竹内研時, 若林チヒロ, 仲井雪絵, 中野恵美子, 有泉祐吾, 尾島俊之

日本公衆衛生学会総会抄録集　76回　539-539　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
政策声明認知症に対する口腔保健の予防的役割

葭原明弘, 安藤雄一, 深井穫博, 安細敏弘, 伊藤博夫, 佐々木健, 山本龍生, 皆川久美子, 宮本茜, 岩崎正則, 竹内研時, 日本口腔衛生学会, 日本口腔衛生学会疫学研究委員会および政策声明委員会

口腔衛生学会雑誌　67　(4)　251-259　2017/10
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
「口腔保健の新定義」に関する動向

深井穫博, 佐々木健, 野村圭介, 大内章嗣, 安藤雄一, 小川祐司, 岡田寿郎, 嶋崎義浩, 宮崎秀夫, 竹内研時

口腔衛生学会雑誌　67　(4)　306-310　2017/10
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
高齢者施設入所者における現在歯数が発熱に及ぼす影響

岩佐康行, 須磨紫乃, 古田美智子, 竹内研時, 山下喜久

口腔衛生学会雑誌　67　141　2017/04/30

ISSN： 0023-2831
口腔の健康状態及び歯科保健サービスが歯科医療費及び医療費に与える影響に関する文献レビュー

竹内研時, 佐藤遊洋, 須磨紫乃, 古田美智子, 岡部優花, 田中照彦, 小坂健, 山下喜久

口腔衛生学会雑誌　67　129　2017/04/30

ISSN： 0023-2831
メタボリックシンドロームの発症と歯周病および口腔保健行動との関連:5年間の後ろ向きコホート研究

田中照彦, 竹内研時, 古田美智子, 須磨紫乃, 竹下徹, 嶋崎義浩, 品川隆, 山下喜久

口腔衛生学会雑誌　67　150　2017/04/30

ISSN： 0023-2831
舌苔マイクロバイオームが高齢者の発熱に及ぼす影響

影山伸哉, 竹下徹, 須磨紫乃, 古田美智子, 竹内研時, 朝川美加李, 岩佐康行, 山下喜久

口腔衛生学会雑誌　67　107　2017/04/30

ISSN： 0023-2831
舌苔マイクロバイオームの細菌構成と口腔の健康状態の関連

朝川美加李, 竹下徹, 影山伸哉, 古田美智子, 竹内研時, 須磨紫乃, 山下喜久

口腔衛生学会雑誌　67　107　2017/04/30

ISSN： 0023-2831
福岡県12歳児のう蝕の有病状況と地域の社会経済状態との検討

岡部優花, 竹内研時, 古田美智子, 山下喜久

口腔衛生学会雑誌　67　162　2017/04/30

ISSN： 0023-2831
要介護高齢者における義歯の装着と認知機能との関連

須磨紫乃, 古田美智子, 竹内研時, 岩佐康行, 山下喜久

口腔衛生学会雑誌　67　139　2017/04/30

ISSN： 0023-2831
口腔が健康な日本人成人における唾液のマイクロバイオームの特徴(Characteristics of salivary microbiome in orally-healthy Japanese adults)

竹下徹, 影山伸哉, 朝川美加李, 古田美智子, 竹内研時, 二宮利治, 山下喜久

日本細菌学雑誌　72　(1)　58-58　2017/02
Publisher: 日本細菌学会
ISSN： 0021-4930
口腔清掃が困難な環境下におけるキシリトール配合ガム摂取が口腔環境へ与える影響

朝川美加李, 竹内研時, 葉柴崇文, 竹下徹, 佐伯洋二, 山下喜久

口腔衛生学会雑誌　67　(1)　45　2017/01/30

ISSN： 0023-2831
要介護高齢者における義歯の装着が認知機能に及ぼす影響

須磨紫乃, 古田美智子, 竹内研時, 冨岡未記子, 岩佐康行, 山下喜久

口腔衛生学会雑誌　67　(1)　44‐45　2017/01/30

ISSN： 0023-2831
九州・沖縄地方における集団応用フッ化物洗口普及の推移―1990~2016年の県別比較の結果―

晴佐久悟, 晴佐久悟, 古田美智子, 古田美智子, 竹内研時, 岩瀬達雄, 重政昭彦, 市野浩司, 森木大輔, 加藤進作, 難波亮二, 木本一成, 木本一成, 筒井昭仁, 田浦勝彦, 境脩

口腔衛生学会雑誌　67　(1)　41-42　2017/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
認知機能が嚥下機能を介して栄養状態に与える効果の検証

竹内研時, 泉繭依, 古田美智子, 岡部優花, 我那覇生純, 山下喜久

日本摂食・嚥下リハビリテーション学会雑誌　20　(3)　S152-S152　2016/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
義歯装着が嚥下機能に及ぼす効果について

岡部優花, 古田美智子, 竹内研時, 木村年秀, 後藤拓朗, 山下喜久

日本摂食・嚥下リハビリテーション学会雑誌　20　(3)　S300-S300　2016/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
Association between Oral Health and Lifestyle-related Diseases in Community-dwelling People: The Hisayama Study

古田美智子, 竹内研時, 竹下徹, 柴田幸江, 二宮利治, 清原裕, 山下喜久

口腔衛生学会雑誌　66　(5)　465‐474-474　2016/10/30
Publisher: Japanese Society for Oral Health
DOI： 10.5834/jdh.66.5_465 　

ISSN： 0023-2831

More details Close

It is important to prevent lifestyle-related diseases to extend healthy life expectancy. Although maintaining oral health is known to prevent lifestyle-related diseases, the association has not yet been elucidated. Here, we investigated the association between oral health and lifestyle-related diseases in a population of community-dwelling people.We recruited 2,523 people, aged 40-79 years, from subjects who participated in the 2007 Hisayama study. Each subject received a dental examination. To rate the oral health status, the number of teeth, periodontal pocket depth, and experience of dental caries were assessed. To rate the lifestyle-related disease status, the presence of diabetes, hypertension, and dyslipidemia was assessed. The absence of any disease was defined as "no lifestyle-related disease." Subjects were stratified into two age groups (40-59 and 60-79 years). We performed logistic regression analysis with the no lifestyle-related disease condition as a dependent variable and the oral health status as the independent variable.The percentage of subjects with no lifestyle-related disease was 42.0% in the 40-59-year-old group and 17.9% in the 60-79-year-old group. Logistic regression analysis showed that no lifestyle-related disease was associated with a greater number of teeth in the 40-59-year-old group and shallow pocket depth in the 60-79-year-old group, after adjusting for age, sex, body mass index, smoking, alcohol consumption, exercise, and occupational status. Good oral health was associated with good general health, without lifestyle-related diseases. The results suggest that maintaining oral health may contribute to preventing lifestyle-related diseases.
地域高齢者における歯の喪失が認知症発症に及ぼす影響の検討:久山町研究

竹内研時, 古田美智子, 山下喜久, 二宮利治

日本公衆衛生学会総会抄録集　75th　271　2016/10/15

ISSN： 1347-8060
嚥下機能低下による在宅療養高齢者の日常生活動作自立度低下リスクの縦断的検証

竹内研時, 古田美智子, 岡部優花, 秋房住郎, 足立宗久, 木下俊則, 菊谷武, 山下喜久

口腔衛生学会雑誌　66　(2)　271　2016/04/30

ISSN： 0023-2831
歯周組織状態とメタボリックシンドローム発症との関連性:5年間の後ろ向きコホート研究

田中照彦, 古田美智子, 竹内研時, 竹下徹, 嶋崎義浩, 山下喜久

口腔衛生学会雑誌　66　(2)　268　2016/04/30

ISSN： 0023-2831
職業が歯の喪失に与える影響の性差―後ろ向きコホート研究―

原田有理子, 竹内研時, 古田美智子, 山下喜久

口腔衛生学会雑誌　66　(2)　292　2016/04/30

ISSN： 0023-2831
WHOの簡易禁煙介入プログラムと日本の歯科禁煙教育モデルの比較

尾崎和歌子, 蓮田賀子, 埴岡隆, 原田有理子, 竹内研時, 小川祐司

口腔衛生学会雑誌　66　(2)　293　2016/04/30

ISSN： 0023-2831
介護保険施設入所高齢者における噛み合わせと認知機能の関連

竹内研時, 泉繭依, 泉繭依, 古田美智子, 竹下徹, 柴田幸江, 影山伸哉, 我那覇生純, 山下喜久

Journal of Epidemiology (Web)　26　(Supplement 1)　2016

ISSN： 1349-9092
歯の有無が口腔常在細菌叢に与える影響

影山伸哉, 竹内研時, 泉繭依, 我那覇生純, 竹下徹, 柴田幸江, 古田美智子, 山下喜久

口腔衛生学会雑誌　66　(1)　53-53　2016/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
義歯装着が嚥下機能の改善に及ぼす効果の検討

岡部優花, 古田美智子, 竹内研時, 木村年秀, 後藤拓朗, 中村誠司, 山下喜久

口腔衛生学会雑誌　66　(1)　58-58　2016/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
介護保険施設入所高齢者の栄養状態に関わる口腔機能と嚥下機能について

竹内研時, 泉繭依, 古田美智子, 我那覇生純, 山下喜久

日本摂食・嚥下リハビリテーション学会雑誌　19　(3)　S128-S129　2015/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
在宅要介護高齢者における死亡と嚥下機能に関する縦断研究

岡部優花, 古田美智子, 竹内研時, 中村誠司, 山下喜久

日本摂食・嚥下リハビリテーション学会雑誌　19　(3)　S315-S315　2015/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
介護保険施設入所高齢者の栄養状態に関わる口腔機能と嚥下機能について

竹内研時, 泉繭依, 古田美智子, 我那覇生純, 山下喜久

日本摂食・嚥下リハビリテーション学会雑誌　19　(3)　S128-S129　2015/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
在宅要介護高齢者における死亡と嚥下機能に関する縦断研究

岡部優花, 古田美智子, 竹内研時, 中村誠司, 山下喜久

日本摂食・嚥下リハビリテーション学会雑誌　19　(3)　S315-S315　2015/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
在宅要介護高齢者における低栄養と口腔機能に関する縦断研究

岡部優花, 古田美智子, 秋房住郎, 足立宗久, 木下俊則, 菊谷武, 竹内研時, 中村誠司, 山下喜久

口腔衛生学会雑誌　65　(2)　181-181　2015/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
生活機能の低下が口腔常在細菌叢に与える影響

影山伸哉, 竹内研時, 泉繭依, 我那覇生純, 竹下徹, 柴田幸江, 古田美智子, 山下喜久

口腔衛生学会雑誌　65　(2)　195-195　2015/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
血清抗体価による歯周疾患重症化リスクの縦断的検証久山町研究

竹内研時, 古田美智子, 竹下徹, 柴田幸江, 嶋崎義浩, 秋房住郎, 山下喜久

口腔衛生学会雑誌　65　(2)　219-219　2015/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
在宅療養要介護高齢者の口腔機能と生活活動動作に関する縦断的検討

古田美智子, 秋房住郎, 岡部優花, 足立宗久, 木下俊則, 竹内研時, 中村誠司, 菊谷武, 山下喜久

口腔衛生学会雑誌　65　(2)　251-251　2015/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
お口に関する市民アンケート調査を用いた福岡市における歯科節目健診の認知度に関わる要因の検討

竹内研時, 古田美智子, 安永愛, 出分菜々衣, 山下喜久

口腔衛生学会雑誌　64　(5)　430-430　2014/10
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
健康高齢者および在宅・施設入所要介護高齢者における口腔の健康状態

古田美智子, 秋房住郎, 菊谷武, 冨岡未記子, 岩佐康行, 竹内研時, 竹下徹, 柴田幸恵, 嶋崎義浩, 清原裕, 山下喜久

口腔衛生学会雑誌　64　(5)　432-433　2014/10
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
在宅療養要介護者における口腔の健康状態と肺炎、発熱の関係について

岡部優花, 古田美智子, 竹内研時, 中村誠司, 山下喜久

老年歯科医学　29　(2)　143-144　2014/09
Publisher: (一社)日本老年歯科医学会
ISSN： 0914-3866
重度の口腔乾燥感に関わる要因の検討久山町研究

竹内研時, 古田美智子, 岡部優花, 山下喜久

老年歯科医学　29　(2)　157-158　2014/09
Publisher: (一社)日本老年歯科医学会
ISSN： 0914-3866
在宅療養要介護高齢者における口腔機能と死亡に関するコホート研究

古田美智子, 竹内研時, 岡部優花, 菊谷武, 山下喜久

老年歯科医学　29　(2)　209-210　2014/09
Publisher: (一社)日本老年歯科医学会
ISSN： 0914-3866
コホートデータを用いた刺激唾液分泌量の減少に関わる要因の検討久山町研究

竹内研時, 古田美智子, 竹下徹, 柴田幸江, 嶋崎義浩, 秋房住郎, 山下喜久

口腔衛生学会雑誌　64　(2)　231-231　2014/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
誤嚥性肺炎の予防に繋がる咳嗽力の維持・向上を目指した口腔ケアの検討

泉繭依, 泉繭依, 我那覇生純, 竹内研時, 山下喜久

8020公募研究報告書抄録(Web)　2014　2014
血清中Porphyromonas gingivalisの抗体価および全身状態が歯周組織状態に及ぼす影響についてのコホート研究

古田美智子, 嶋崎義浩, 竹内研時, 田中俊一, 山下喜久

口腔衛生学会雑誌　64　(1)　52-52　2014/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
高齢者の無歯顎の地域格差とソーシャルキャピタルの関連 JAGESプロジェクト

相田潤, 近藤克則, 山本龍生, 竹内研時, 小坂健

日本公衆衛生学会総会抄録集　72回　460-460　2013/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
P-47 歯周病と脳卒中の関連:測定指標の差異を考慮したメタアナリシス(ポスター)

松山祐輔, 相田潤, 竹内研時, 伊藤奏, 中安美枝子, 小山史穂子, 長谷晃広, 成田展章, 坪谷透, 小坂健

口腔衛生学会雑誌　63　(2)　189-189　2013/04/30
Publisher: 有限責任中間法人日本口腔衛生学会
ISSN： 0023-2831
P-73 口腔ケアによる肺炎の抑制効果 : メタアナリシスによる検討(ポスター)

長谷晃広, 相田潤, 竹内研時, 伊藤奏, 中安美枝子, 小山史穂子, 成田展章, 坪谷透, 小坂健

口腔衛生学会雑誌　63　(2)　204-204　2013/04/30
Publisher: 有限責任中間法人日本口腔衛生学会
ISSN： 0023-2831
歯周病と脳卒中の関連測定指標の差異を考慮したメタアナリシス

松山祐輔, 相田潤, 竹内研時, 伊藤奏, 中安美枝子, 小山史穂子, 長谷晃広, 成田展章, 坪谷透, 小坂健

口腔衛生学会雑誌　63　(2)　189-189　2013/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
口腔ケアによる肺炎の抑制効果メタアナリシスによる検討

長谷晃広, 相田潤, 竹内研時, 伊藤奏, 中安美枝子, 小山史穂子, 成田展章, 坪谷透, 小坂健

口腔衛生学会雑誌　63　(2)　204-204　2013/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東日本大震災による義歯喪失と口腔のQOLの関連

佐藤遊洋, 相田潤, 竹内研時, 若栗真太郎, 冨士岳志, 服部佳功, 小関健由, 小坂健, 佐々木啓一, 辻一郎

宮城県公衆衛生学会会誌　(45)　5-5　2013/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
口腔保健とQOLの向上に関する総合的研究口腔と全身疾患に関するシステマティックレビュー 1)歯周病と脳卒中の関連:測定指標の差異を考慮したメタアナリシス

小坂健, 松山祐輔, 長谷晃広, 相田潤, 坪谷透, 竹内研時, 伊藤奏, 小山史穂子, 中安美枝子, 成田展章

口腔保健とQOLの向上に関する総合的研究平成24年度総括・分担研究報告書　25-28　2013
口腔保健とQOLの向上に関する総合的研究口腔と全身疾患に関するシステマティックレビュー 2)口腔ケアによる肺炎の予防効果:メタアナリシスによる検討

小坂健, 長谷晃広, 松山祐輔, 相田潤, 坪谷透, 竹内研時, 伊藤奏, 小山史穂子, 中安美枝子, 成田展章

口腔保健とQOLの向上に関する総合的研究平成24年度総括・分担研究報告書　29-35　2013
自己評価口腔の健康度にはお小遣いが関連するか社会経済的地位指標としてのお小遣いの利用

伊藤奏, 相田潤, 若栗真太郎, 竹内研時, 野口有紀, 小坂健

口腔衛生学会雑誌　62　(2)　205-205　2012/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東日本大震災による歯科医院への通院の中断と再開とその関連要因

末永竜右, 相田潤, 竹内研時, 若栗真太郎, 服部佳功, 小関健由, 小坂健, 佐々木啓一, 辻一郎

口腔衛生学会雑誌　62　(2)　255-255　2012/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
震災による義歯喪失の実態とその影響について

佐藤遊洋, 相田潤, 竹内研時, 若栗真太郎, 服部佳功, 小関健由, 小坂健, 佐々木啓一, 辻一郎

口腔衛生学会雑誌　62　(2)　256-256　2012/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
Gender differences in the association between self-rated oral health and socioeconomic status among Japanese

Shintaro Wakaguri, Kanade Ito, Jun Aida, Kenji Takeuchi, Ken Osaka

Interface Oral Health Science 2011　294-296　2012/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_87 　
Socioeconomic inequalities in tooth loss among Japanese

Kanade Ito, Jun Aida, Shintaro Wakaguri, Kenji Takeuchi, Yuki Noguchi, Ken Osaka

Interface Oral Health Science 2011　291-293　2012/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_86 　
介護保険の総合的政策評価ベンチマーク・システムの開発 4)マルチレベル分析・GIS(地理情報システム)を用いた分析ソーシャルキャピタルと高齢者の残存歯数の関連;J‐AGESプロジェクト

小坂健, 山本龍生, 相田潤, 竹内研時

介護保険の総合的政策評価ベンチマーク・システムの開発平成23年度総括・分担研究報告書　170-175　2012
歯科医療関連職種と歯科医療機関の業務のあり方及び需給予測に関する研究口腔保健における需要を考える:口腔衛生学会自由集会における討論

安藤雄一, 大内章嗣, 大山篤, 恒石美登里, 神光一郎, 深井穫博, 瀧口徹, 古川清香, 竹内研時, 木下淳博

歯科医療関連職種と歯科医療機関の業務のあり方及び需給予測に関する研究平成23年度総括・分担研究報告書　85-90　2012
在宅療養支援診療所の概況と医科歯科連携

小野瑞穂, 若栗真太郎, 松山祐輔, 竹内研時, 伊藤奏, 相田潤, 小坂健

日本公衆衛生学会総会抄録集　70回　329-329　2011/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
在宅療養における医科歯科連携の実施状況と連携拡大に求められる事項の検討

松山祐輔, 若栗真太郎, 小野瑞穂, 竹内研時, 伊藤奏, 相田潤, 小坂健

日本公衆衛生学会総会抄録集　70回　329-329　2011/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高齢者における社会参加と口腔の主観的健康度の関連

竹内研時, 相田潤, 小坂健, 近藤克則

日本公衆衛生学会総会抄録集　70回　342-342　2011/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
お小遣いか世帯収入か? 仮想評価法を用いた歯の健康への支払意思額との関連

伊藤奏, 相田潤, 竹内研時, 小坂健

日本公衆衛生学会総会抄録集　70回　342-342　2011/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高等学校における新型インフルエンザ感染拡大時の対応の現状

長谷晃広, 竹内研時, 若栗真太郎, 伊藤奏, 相田潤, 小坂健

日本公衆衛生学会総会抄録集　70回　417-417　2011/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
在宅療養者における口腔内と栄養摂取状態との関連

若栗真太郎, 相田潤, 竹内研時, 伊藤奏, 野口有紀, 小坂健

老年歯科医学　26　(2)　163-164　2011/09
Publisher: (一社)日本老年歯科医学会
ISSN： 0914-3866
一般住民の訪問歯科診療に対する認知に関する研究

白川力丸, 伊藤奏, 若栗真太郎, 竹内研時, 相田潤, 小坂健

老年歯科医学　26　(2)　212-213　2011/09
Publisher: (一社)日本老年歯科医学会
ISSN： 0914-3866
高齢者における社会参加と残存歯数の関連

竹内研時, 相田潤, 小坂健, 近藤克則

口腔衛生学会雑誌　61　(4)　429-429　2011/08
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
仮想評価法を用いた歯の健康に対する支払意思額と社会経済的地位との関連について

伊藤奏, 相田潤, 若栗真太郎, 野口有紀, 竹内研時, 小坂健

口腔衛生学会雑誌　61　(4)　430-430　2011/08
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
都道府県主体の歯科保健推進条例制定を進めるために

竹内研時, 岩城倫弘, 田口千恵子, 田浦勝彦, 小林清吾, 相田潤, 小坂健

口腔衛生学会雑誌　61　(4)　487-487　2011/08
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
口腔保健とQOLの向上に関する総合的研究高齢者の口腔と全身の健康に影響する要因に関する研究

小坂健, 竹内研時, 松山祐輔

口腔保健とQOLの向上に関する総合的研究平成22年度研究報告書　22-24　2011
歯科医師の需給に関する研究女性歯科医師数の医師・薬剤師との推移比較

竹内研時, 安藤雄一, 古川清香, 小坂健, 児玉知子

日本公衆衛生学会総会抄録集　69回　195-195　2010/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
介護施設における新型インフルエンザ対策に関する調査研究

小坂健, 竹内研時, 相田潤

日本公衆衛生学会総会抄録集　69回　461-461　2010/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
思春期におけるフッ化物配合歯磨剤使用に関する意識調査

野口有紀, 若栗真太郎, 竹内研時, 伊藤奏, 相田潤, 小坂健

口腔衛生学会雑誌　60　(4)　449-449　2010/08
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
性・年齢階級別にみた歯科医師数の推移医師・歯科医師・薬剤師調査を用いた分析

竹内研時, 安藤雄一, 大内章嗣, 古川清香, 小坂健

口腔衛生学会雑誌　60　(4)　474-474　2010/08
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
マルチレベル分析による親の喫煙行動と社会環境に関する研究

竹内研時, 相田潤, 森田学, 安藤雄一, 小坂健

J Epidemiol　20　(Supplement 1)　S117　2010/01/09

ISSN： 0917-5040

Show all ︎Show first 5

Books and Other Publications 6

新編衛生学・公衆衛生学

安井利一他(編), 竹内研時他(著)

医歯薬出版社　2021/02
フロリデーション・ファクツ２０１８科学的根拠に基づく水道水フロリデーション

日本口腔衛生学会フッ化物応用委員(編), 小林清吾他(監), 竹内研時他(訳)

口腔保健協会　2020/11
健康長寿のための口腔保健と栄養をむすぶエビデンスブック

深井穫博(編), 竹内研時他(著)

医歯薬出版　2019/08
認知症の人への歯科治療ガイドライン

日本老年歯科医学(編), 平野浩彦他(著), 竹内研時他(コンセンサスボード)

医歯薬出版　2019/06
オーストラリアにおける水道水フロリデーション

NPO法人日本フッ化物むし歯予防協会(編), 竹内研時他(訳)

口腔保健協会　2019/02
MNA在宅栄養ケア在宅高齢者の低栄養予防と早期発見

葛谷雅文他(編), 竹内研時他(著)

医歯薬出版　2015/01

ISBN: 4263706374

Show all Show first 5

Presentations 108

(シンポジスト: 歯科衛生研究について考える) 歯学教育での研究指導 Invited

竹内研時

第16回日本歯科衛生教育学会総会・学術大会　2025/12/06
(ランチョンセミナー講師: 口腔の健康と食事・飲料との関りについて) 飲料を含む食事や食行動などの食生活と口腔の健康の関わり Invited

竹内研時

第49回日本口蓋裂学会総会・学術集会　2025/10/24
(シンポジスト: エビデンスに基づく実践・政策および実践・政策に基づくエビデンス) リアルワールドデータに基づく歯科政策科学研究の実践 Invited

竹内研時

第25回日本歯科医学会学術大会　2025/09/28
(シンポジスト: 栄養疫学の可能性と展開～ライフコースを通じた健康への貢献) 疾病予防と健康における歯科口腔保健の重要性 Invited

竹内研時

第79回日本栄養・食糧学会大会　2025/05/25
(シンポジスト: 歯科医療供給が大きく変わり始めた今，歯科保健医療提供体制の在り方を中長期的視点から考える) 歯科疾患の疾病負担への理解と対策：ギャップを埋め，視野を広げる Invited

竹内研時

第74回日本口腔衛生学会学術大会　2025/05/18
(基調講演: 働く人々の全身の健康づくりに寄与できる歯科口腔保健) 就労世代の健康づくりに向けた歯科口腔保健の役割 Invited

竹内研時

第98回日本産業衛生学会　2025/05/15
(シンポジスト: 歯科保健を通じたwell-beingの向上を考える) コホート研究から探る健康寿命延伸に向けた口腔の健康の役割 Invited

竹内研時

第34回日本全身咬合学会学術大会　2024/11/23
(座長: 歯科口腔保健の推進に関する基本的事項（第２次）をどう見るかー政策科学の観点からー) Invited

竹内研時

2024/05/12
(シンポジスト: AIとDXが切り開くビッグデータ時代の歯科医療) 歯科保健医療ビッグデータ活用事例と今後の活用について Invited

竹内研時

2024/05/12
(座長: 基礎・臨床・疫学若手研究者からの令和の健口戦略 ―どうするミレニアル世代！？―) Invited

竹内研時

2024/05/11
(シンポジスト: ポジティブ心理を用いた疾病予防・健康増進の社会実装) 笑いの健康効果：笑いの社会的利用の実装に向けて Invited

竹内研時

第82回日本公衆衛生学会総会　2023/11/01
明日からできる臨床疫学研究 ―臨床疫学統計支援室の利活用について―

竹内研時

歯学教育FD　2023/08/25
(シンポジスト: 歯科口腔保健医療のエビデンスと政策を考える) 歯科口腔保健の医療経済的エビデンス Invited

竹内研時

第72回日本口腔衛生学会学術大会　2023/05/20
(非専門家部門優秀演題賞) 保健・医療・行政データを用いた、test-negativeデザインによるCOVID-19ワクチンの有効性評価：VENUS Study

玉田雄大, 竹内研時, 草間太郎, 小坂健, 前田恵, 村田典子, 福田治久

日本臨床疫学会第5回年次学術大会　2022/11/13
(シンポジスト: 新型コロナ・新型タバコ時代の禁煙推進方策－新しい問題に立ち向かう－) 新型タバコも含めた喫煙・受動喫煙の社会格差 Invited

竹内研時

第81回日本公衆衛生学会総会　2022/10/08
(シンポジスト: 実践および健康政策につなげる研究展開と基盤整備) 歯周疾患検診有効性の検討

竹内研時

第21回深井保健科学研究所コロキウム　2022/08/28
(座長: 統計手法を用いた観察研究からの因果推論の可能性)

竹内研時

第21回深井保健科学研究所コロキウム　2022/08/28
Impact of Poverty on Frequent Dental Pain Among US Adults International-presentation

Muthuthanthrige Cooray, Kenji Takeuchi, Ken Osaka, Jun Aida

The 100th IADR General Session & Exhibition　2022/06/23
(WINNER: JADR/GC Young Investigator Award) The Association Between Tooth Brushing and Covid-19 Main Symptoms. International-presentation

Hazem Abbas, Kenji Takeuchi, Shihoko Koyama, Ken Osaka, Takahiro Tabuchi

The 100th IADR General Session & Exhibition　2022/06/23
Tooth loss increases cumulative long-term care costs. International-presentation

Kenji Takeuchi, Masashige Saito, Yudai Tamada, Yasuhiro Miyaguni, Kinya Fujita, Naoki Kondo, Jun Aida, Taro Kusama, Ken Osaka, Katsunori Kondo

The 100th IADR General Session & Exhibition　2022/06/22
(Panelist: Global oral health and healthcare policies) International-presentation Invited

Kenji Takeuchi

The International Oral Health Symposium 2022　2022/06/07
(シンポジスト: WHO の口腔保健の決議を受けて：学術的視点から考えるフッ化物応用) 医療経済的側面からみたフッ化物洗口 Invited

竹内研時

第71回日本口腔衛生学会総会　2022/05/13
(Symposiast: Data health) The results of cohort studies of a highly generalizable population and nationwide big data studies, and the future of epidemiological research using real-world data. International-presentation Invited

Kenji Takeuchi

International Symposium for Interface Oral Health Science　2022/01/15
(シンポジスト: 医療保険・介護保険制度における歯科受診・受療) 高齢期の口腔の健康状態による介護医療費格差

竹内研時

第20回深井保健科学研究所コロキウム　2021/09/19
(シンポジスト: 口腔衛生・予防歯科研究の新たな展開－その専門性を問う－) 歯科医師兼疫学者がライフワークとする研究を見つけるために Invited

竹内研時

第70回日本口腔衛生学会総会　2021/05/27
(シンポジスト: 口とこころ～口腔と精神保健) 口腔保健から考える認知症予防 Invited

竹内研時

第42回九州口腔衛生学会　2020/09/06
(シンポジスト: 歯科医療機関における感染予防のNew Normal) 緊急事態宣言下での歯科医院の状況と一般住民の受診行動

竹内研時

第19回深井保健科学研究所コロキウム　2020/08/30
(座長: 保健医療システムのNew Normal)

竹内研時, 安藤雄一

第19回深井保健科学研究所コロキウム　2020/08/30
(シンポジスト: 『生涯28』の科学的根拠について考える) 歯の喪失の歯科・医科医療費への影響 Invited

竹内研時

第69回日本口腔衛生学会総会　2020/04/24
(シンポジスト: 公衆衛生と医療) 疫学研究から政策への架け橋

竹内研時

第18回深井保健科学研究所コロキウム　2019/08/04
Association of Oral Microbiota with Digestive Tract Cancers.

Kageyama S, Takeshita T, Asakawa M, Matsumi R, Takeuchi K, Nagai K, Morita M, Masuda M, Toh Y, Ninomiya T, Kiyohara Y, Yamashita Y

The 97th IADR General Session & Exhibition　2019/06/22
(受賞講演: 日本口腔衛生学会学術賞LION AWARD) Tooth loss and risk of dementia in the community: the Hisayama Study Invited

竹内研時

第68回日本口腔衛生学会総会　2019/05/24
(シンポジスト: 地域歯科保健人材養成プログラムの概要と今後の在り方) 地域歯科保健を支える歯科医師・研究者に求められる知識・技能と課題 Invited

竹内研時

第68回日本口腔衛生学会総会　2019/05/23
(座長: シンポジウムⅠ コホート研究における対象年齢とアウトカム評価)

竹内研時, 岩崎正則

第17回深井保健科学研究所コロキウム　2018/08/19
Characterization of Oral Microbiota and Acetaldehyde Production. International-presentation

Takeuchi K, Yokoyama S, Shibata Y, Matsumi R, Kageyama S, Takeshita T, Yamashita Y

The 96th IADR General Session & Exhibition　2018/07/28
Periodontal Status and Lung Function in Middle-Aged and Older Adults. International-presentation

Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomya T, Yamashita Y

The 96th IADR General Session & Exhibition　2018/07/26
九州・沖縄地方における集団応用フッ化物洗口普及の推移第2報県別の実施市町村の割合,施設別の実施状況と公的支援状況について

田浦勝彦, 晴佐久悟, 古田美智子, 竹内研時, 井上文子, 岩瀬達雄, 重政昭彦, 市野浩司, 難波亮二, 森木大輔, 加藤進作, 木本一成, 筒井昭仁, 境脩, 山内皓央

口腔衛生学会雑誌　2018/01/30
歯周疾患検診受診率の推移とその地域差に関する検討

矢田部尚子, 古田美智子, 竹内研時, 須磨紫乃, 渕田慎也, 山本龍生, 山下喜久

口腔衛生学会雑誌　2018/01/30
農山村地域における地縁的な活動への参加と主観的健康感との関連

野口有紀, 伊藤奏, 竹内研時, 若林チヒロ, 仲井雪絵, 中野恵美子, 有泉祐吾, 尾島俊之

日本公衆衛生学会総会抄録集　2017/10/15
地域一般住民における呼吸機能低下に及ぼす歯周病の影響の検討

竹内研時, 古田美智子, 須磨紫乃, 秦淳, 二宮利治, 山下喜久

日本公衆衛生学会総会抄録集　2017/10/15
要介護高齢者における義歯の装着と認知機能との関連

須磨紫乃, 古田美智子, 竹内研時, 岩佐康行, 山下喜久

口腔衛生学会雑誌　2017/04/30
福岡県12歳児のう蝕の有病状況と地域の社会経済状態との検討

岡部優花, 竹内研時, 古田美智子, 山下喜久

口腔衛生学会雑誌　2017/04/30
舌苔マイクロバイオームの細菌構成と口腔の健康状態の関連

朝川美加李, 竹下徹, 影山伸哉, 古田美智子, 竹内研時, 須磨紫乃, 山下喜久

口腔衛生学会雑誌　2017/04/30
舌苔マイクロバイオームが高齢者の発熱に及ぼす影響

影山伸哉, 竹下徹, 須磨紫乃, 古田美智子, 竹内研時, 朝川美加李, 岩佐康行, 山下喜久

口腔衛生学会雑誌　2017/04/30
メタボリックシンドロームの発症と歯周病および口腔保健行動との関連:5年間の後ろ向きコホート研究

田中照彦, 竹内研時, 古田美智子, 須磨紫乃, 竹下徹, 嶋崎義浩, 品川隆, 山下喜久

口腔衛生学会雑誌　2017/04/30
口腔の健康状態及び歯科保健サービスが歯科医療費及び医療費に与える影響に関する文献レビュー

竹内研時, 佐藤遊洋, 須磨紫乃, 古田美智子, 岡部優花, 田中照彦, 小坂健, 山下喜久

口腔衛生学会雑誌　2017/04/30
高齢者施設入所者における現在歯数が発熱に及ぼす影響

岩佐康行, 須磨紫乃, 古田美智子, 竹内研時, 山下喜久

口腔衛生学会雑誌　2017/04/30
口腔が健康な日本人成人における唾液のマイクロバイオームの特徴(Characteristics of salivary microbiome in orally-healthy Japanese adults)

竹下徹, 影山伸哉, 朝川美加李, 古田美智子, 竹内研時, 二宮利治, 山下喜久

日本細菌学雑誌　2017/02
地域高齢者における歯の喪失が認知症発症に及ぼす影響の検討久山町研究

竹内研時, 古田美智子, 山下喜久, 二宮利治

第75回日本公衆衛生学会総会　2016/10/27
義歯装着が嚥下機能に及ぼす効果について

岡部優花, 古田美智子, 竹内研時, 木村年秀, 後藤拓朗, 山下喜久

第22回日本摂食嚥下リハビリテーション学会学術大会　2016/09/24
認知機能が嚥下機能を介して栄養状態に与える効果の検証

竹内研時, 泉繭依, 古田美智子, 岡部優花, 我那覇生純, 山下喜久

第22回日本摂食嚥下リハビリテーション学会学術大会　2016/09/23
(優秀発表賞) 要介護高齢者における義歯の装着が認知機能に及ぼす影響

須磨紫乃, 古田美智子, 竹内研時, 冨岡未記子, 岩佐康行, 山下喜久

第38回九州口腔衛生学会総会　2016/09/04
九州・沖縄地方における集団応用フッ化物洗口普及の推移―1990~2016年の県別比較の結果―

晴佐久悟, 晴佐久悟, 古田美智子, 古田美智子, 竹内研時, 岩瀬達雄, 重政昭彦, 市野浩司, 森木大輔, 加藤進作, 難波亮二, 木本一成, 木本一成, 筒井昭仁, 田浦勝彦, 境脩

第38回九州口腔衛生学会総会　2016/09/04
口腔清掃が困難な環境下におけるキシリトール配合ガム摂取が口腔環境へ与える影響

朝川美加李, 竹内研時, 葉柴崇文, 竹下徹, 佐伯洋二, 山下喜久

第38回九州口腔衛生学会総会　2016/09/04
(FIRST PRIZE: The J. Morita Post-doctoral Award for Junior Investigators for Geriatric Oral Research) Posterior Teeth Occlusion and Functional Dependence Among Japanese Older Adults International-presentation

Takeuchi K, Izumi M, Furuta M, Takeshita T, Shibata Y, Kageyama S, Ganaha S, Yamashita Y

The 94th IADR General Session & Exhibition　2016/06/25
(WINNER: The IADR BEHSR student abstract award) Gender-Specific Association Between Periodontal Disease and Job Classification Among Employees International-presentation

Y. Harada, K. Takeuchi, M. Furuta, S. Tanaka, Y. Yamashita

The 94th IADR General Session & Exhibition　2016/06/24
歯周組織状態とメタボリックシンドローム発症との関連性：5 年間の後ろ向きコホート研究

田中照彦, 古田美智子, 竹内研時, 竹下徹, 嶋崎義浩, 山下喜久

第65回日本口腔衛生学会総会　2016/05/29
嚥下機能低下による在宅療養高齢者の日常生活動作自立度低下リスクの縦断的検証

竹内研時, 古田美智子, 岡部優花, 秋房住郎, 足立宗久, 木下俊則, 菊谷武, 山下喜久

第65回日本口腔衛生学会総会　2016/05/29
WHO の簡易禁煙介入プログラムと日本の歯科禁煙教育モデルの比較.

尾崎和歌子, 蓮田賀子, 埴岡隆, 原田有理子, 竹内研時, 小川祐司

第65回日本口腔衛生学会総会　2016/05/28
職業が歯の喪失に与える影響の性差─後ろ向きコホート研究─

原田有理子, 竹内研時, 古田美智子, 山下喜久

第65回日本口腔衛生学会総会　2016/05/28
WHOの簡易禁煙介入プログラムと日本の歯科禁煙教育モデルの比較

尾崎和歌子, 蓮田賀子, 埴岡隆, 原田有理子, 竹内研時, 小川祐司

口腔衛生学会雑誌　2016/04
職業が歯の喪失に与える影響の性差後ろ向きコホート研究

原田有理子, 竹内研時, 古田美智子, 山下喜久

口腔衛生学会雑誌　2016/04
嚥下機能低下による在宅療養高齢者の日常生活動作自立度低下リスクの縦断的検証

竹内研時, 古田美智子, 岡部優花, 秋房住郎, 足立宗久, 木下俊則, 菊谷武, 山下喜久

口腔衛生学会雑誌　2016/04
歯周組織状態とメタボリックシンドローム発症との関連性 5年間の後ろ向きコホート研究

田中照彦, 古田美智子, 竹内研時, 竹下徹, 嶋崎義浩, 山下喜久

口腔衛生学会雑誌　2016/04
介護保険施設入所高齢者における噛み合わせと認知機能の関連

竹内研時, 泉繭依, 古田美智子, 竹下徹, 柴田幸江, 影山伸哉, 我那覇生純, 山下喜久

第26回日本疫学会学術総会　2016/01/23
(WINNER: Joseph Lister Award) Gender Differences in the Association between Periodontal Condition and Socioeconomic Status in Japanese Employees. International-presentation

Yuriko Harada, Kenji Takeuchi, Michiko Furuta, Shunichi Tanaka, Yoshihisa Yamashita

The 63rd Annual Meeting of Japanese Association for Dental Research.　2015/10/30
介護保険施設入所高齢者の栄養状態に関わる口腔機能と嚥下機能.

竹内研時, 泉繭依, 古田美智子, 我那覇生純, 山下喜久

第21回日本摂食嚥下リハビリテーション学会学術大会　2015/09/11
(優秀発表賞) 歯の有無が口腔常在細菌叢に与える影響

影山伸哉, 竹内研時, 泉繭依, 我那覇生純, 竹下徹, 柴田幸江, 古田美智子, 山下喜久

第37回九州口腔衛生学会総会　2015/09/06
在宅療養要介護高齢者の口腔機能と生活活動動作に関する縦断的検討

古田美智子, 秋房住郎, 岡部優花, 足立宗久, 木下俊則, 竹内研時, 中村誠司, 菊谷武, 山下喜久

口腔衛生学会雑誌　2015/04
血清抗体価による歯周疾患重症化リスクの縦断的検証久山町研究

竹内研時, 古田美智子, 竹下徹, 柴田幸江, 嶋崎義浩, 秋房住郎, 山下喜久

口腔衛生学会雑誌　2015/04
生活機能の低下が口腔常在細菌叢に与える影響

影山伸哉, 竹内研時, 泉繭依, 我那覇生純, 竹下徹, 柴田幸江, 古田美智子, 山下喜久

口腔衛生学会雑誌　2015/04
在宅要介護高齢者における低栄養と口腔機能に関する縦断研究

岡部優花, 古田美智子, 秋房住郎, 足立宗久, 木下俊則, 菊谷武, 竹内研時, 中村誠司, 山下喜久

口腔衛生学会雑誌　2015/04
健康高齢者および在宅・施設入所要介護高齢者における口腔の健康状態

古田美智子, 秋房住郎, 菊谷武, 冨岡未記子, 岩佐康行, 竹内研時, 竹下徹, 柴田幸恵, 嶋崎義浩, 清原裕, 山下喜久

口腔衛生学会雑誌　2014/10
在宅療養要介護者における口腔の健康状態と肺炎,発熱の関係について

OKABE YUKA, FURUTA MICHIKO, TAKEUCHI KENJI, NAKAMURA SEIJI, YAMASHITA YOSHIHISA

老年歯科医学　2014/09/30
在宅療養要介護高齢者における口腔機能と死亡に関するコホート研究

古田美智子, 竹内研時, 岡部優花, 菊谷武, 山下喜久

老年歯科医学　2014/09
(優秀発表賞) お口に関する市民アンケート調査を用いた福岡市における歯科節目健診の認知度に関わる要因の検討

竹内研時, 古田美智子, 安永愛, 出分菜々衣, 山下喜久

第36回九州口腔衛生学会総会　2014/07/27
コホートデータを用いた刺激唾液分泌量の減少に関わる要因の検討:久山町研究

TAKEUCHI KENJI, FURUTA MICHIKO, TAKESHITA TOORU, SHIBATA YUKIE, SHIMAZAKI YOSHIHIRO, AKIFUSA SUMIO, YAMASHITA YOSHIHISA

口腔衛生学会雑誌　2014/04/30
血清中Porphyromonas gingivalisの抗体価および全身状態が歯周組織状態に及ぼす影響についてのコホート研究

FURUTA MICHIKO, SHIMAZAKI YOSHIHIRO, TAKEUCHI KENJI, TANAKA SHUN'ICHI, YAMASHITA YOSHIHISA

口腔衛生学会雑誌　2014/01/30
高齢者の無歯顎の地域格差とソーシャルキャピタルの関連;JAGESプロジェクト

AIDA JUN, KONDO KATSUNORI, YAMAMOTO TATSUO, TAKEUCHI KENJI, OSAKA KEN

日本公衆衛生学会総会抄録集　2013/10/15
口腔ケアによる肺炎の抑制効果:メタアナリシスによる検討

HASE AKIHIRO, AIDA JUN, TAKEUCHI KENJI, ITO SUSUMU, NAKAYASU MIEKO, KOYAMA SHIHOKO, NARITA NOBUAKI, TSUBOTANI TOORU, OSAKA KEN

口腔衛生学会雑誌　2013/04/30
歯周病と脳卒中の関連:測定指標の差異を考慮したメタアナリシス

MATSUYAMA YUSUKE, AIDA JUN, TAKEUCHI KENJI, ITO SUSUMU, NAKAYASU MIEKO, KOYAMA SHIHOKO, HASE AKIHIRO, NARITA NOBUAKI, TSUBOTANI TOORU, OSAKA KEN

口腔衛生学会雑誌　2013/04/30
Social Participation and Dental Health Status among Older Japanese. International-presentation

Takeuchi K, Aida J, Kondo K, Osaka K

IADR General Session & Exhibition.　2013/03/21
東日本大震災による義歯喪失と口腔のQOLの関連

SATO YUKIHIRO, AIDA JUN, TAKEUCHI KENJI, WAKAGURI SHINTARO, FUJI TAKESHI, HATTORI YOSHINORI, KOSEKI TAKEYOSHI, OSAKA KEN, SASAKI KEIICHI, TSUJI ICHIRO

宮城県公衆衛生学会会誌　2013/03
仮設住宅居住者における心理的ストレスのリスク要因の検討

KOYAMA SHIHOKO, AIDA JUN, TAKEUCHI KENJI, ITO SUSUMU, MASUNO KANAKO, KONDO KATSUNORI, OSAKA KEN

J Epidemiol　2013/01/24
口腔保健とQOLの向上に関する総合的研究口腔と全身疾患に関するシステマティックレビュー 2)口腔ケアによる肺炎の予防効果:メタアナリシスによる検討

OSAKA KEN, HASE AKIHIRO, MATSUYAMA YUSUKE, AIDA JUN, TSUBOYA TOORU, TAKEUCHI KENJI, ITO SUSUMU, KOYAMA SHIHOKO, NAKAYASU MIEKO, NARITA NOBUAKI

口腔保健とQOLの向上に関する総合的研究平成24年度総括・分担研究報告書　2013
口腔保健とQOLの向上に関する総合的研究口腔と全身疾患に関するシステマティックレビュー 1)歯周病と脳卒中の関連:測定指標の差異を考慮したメタアナリシス

OSAKA KEN, MATSUYAMA YUSUKE, HASE AKIHIRO, AIDA JUN, TSUBOYA TOORU, TAKEUCHI KENJI, ITO SUSUMU, KOYAMA SHIHOKO, NAKAYASU MIEKO, NARITA NOBUAKI

口腔保健とQOLの向上に関する総合的研究平成24年度総括・分担研究報告書　2013
在宅高齢者の生活環境,地域環境および介護予防プログラム・介護サービスと高齢者の健康に関する疫学研究日本の高齢者における社会参加と残存歯数の関連

OSAKA KEN, TAKEUCHI KENJI, KONDO KATSUNORI, AIDA JUN

在宅高齢者の生活環境、地域環境および介護予防プログラム・介護サービスと高齢者の健康に関する疫学研究平成24年度総括・分担研究報告書　2013
自己評価口腔の健康度にはお小遣いが関連するか~社会経済的地位指標としてのお小遣いの利用~

ITO SUSUMU, AIDA JUN, WAKAGURI SHINTARO, TAKEUCHI KENJI, NOGUCHI YUKI, OSAKA KEN

口腔衛生学会雑誌　2012/04/30
東日本大震災による歯科医院への通院の中断と再開とその関連要因

SUENAGA RYUSUKE, AIDA JUN, TAKEUCHI KENJI, WAKAKURI SHINTARO, HATTORI YOSHINORI, KOSEKI TAKEYOSHI, OSAKA KEN, SASAKI KEIICHI, TSUJI ICHIRO

口腔衛生学会雑誌　2012/04/30
震災による義歯喪失の実態とその影響について

SATO YUYO, AIDA JUN, TAKEUCHI KENJI, WAKAKURI SHINTARO, HATTORI YOSHINORI, KOSEKI TAKEYOSHI, OSAKA KEN, SASAKI KEIICHI, TSUJI ICHIRO

口腔衛生学会雑誌　2012/04/30
ソーシャルキャピタルと高齢者の残存歯数の関連;J‐AGESプロジェクト

AIDA JUN, KONDO KATSUNORI, YAMAMOTO TATSUO, TAKEUCHI KENJI, OSAKA KEN

J Epidemiol　2012/01/26
在宅高齢者の栄養状態と誤嚥リスクの把握

TAKEUCHI KENJI, AIDA JUN, ITO SUSUMU, KOYAMA SHIHOKO, YOSHINAKA SUSUMU, OSAKA KEN

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　2012
介護保険の総合的政策評価ベンチマーク・システムの開発 4)マルチレベル分析・GIS(地理情報システム)を用いた分析ソーシャルキャピタルと高齢者の残存歯数の関連;J‐AGESプロジェクト

OSAKA KEN, YAMAMOTO TATSUO, AIDA JUN, TAKEUCHI KENJI

介護保険の総合的政策評価ベンチマーク・システムの開発平成23年度総括・分担研究報告書　2012
歯科医療関連職種と歯科医療機関の業務のあり方及び需給予測に関する研究口腔保健における需要を考える:口腔衛生学会自由集会における討論

ANDO YUICHI, OUCHI AKITSUGU, OYAMA ATSUSHI, TSUNEISHI MIDORI, JIN KOICHIRO, FUKAI KAKUHIRO, TAKIGUCHI TOORU, FURUKAWA KIYOKA, TAKEUCHI KENJI, KINOSHITA ATSUHIRO

歯科医療関連職種と歯科医療機関の業務のあり方及び需給予測に関する研究平成23年度総括・分担研究報告書　2012
都道府県歯科保健条例の記載事項の比較

TAKEUCHI KENJI, AIDA JUN, IWAKI MICHIHIRO, TAGUCHI CHIEKO, TAURA KATSUHIKO, KOBAYASHI SEIGO, OSAKA KEN

ヘルスサイエンス・ヘルスケア　2011/12/15
在宅療養における医科歯科連携の実施状況と連携拡大に求められる事項の検討

MATSUYAMA YUSUKE, WAKAKURI SHINTARO, ONO MIZUHO, TAKEUCHI KENJI, ITO SUSUMU, AIDA JUN, OSAKA KEN

日本公衆衛生学会総会抄録集　2011/10/15
高等学校における新型インフルエンザ感染拡大時の対応の現状

HASE AKIHIRO, TAKEUCHI KENJI, WAKAKURI SHINTARO, ITO SUSUMU, AIDA JUN, OSAKA KEN

日本公衆衛生学会総会抄録集　2011/10/15
高齢者における社会参加と口腔の主観的健康度の関連

TAKEUCHI KENJI, AIDA JUN, OSAKA KEN, KONDO KATSUNORI

日本公衆衛生学会総会抄録集　2011/10/15
お小遣いか世帯収入か?~仮想評価法を用いた歯の健康への支払意思額との関連~

ITO SUSUMU, AIDA JUN, TAKEUCHI KENJI, OSAKA KEN

日本公衆衛生学会総会抄録集　2011/10/15
在宅療養支援診療所の概況と医科歯科連携

ONO MIZUHO, WAKAKURI SHINTARO, MATSUYAMA YUSUKE, TAKEUCHI KENJI, ITO SUSUMU, AIDA JUN, OSAKA KEN

日本公衆衛生学会総会抄録集　2011/10/15
在宅療養者における口腔内と栄養摂取状態との関連

WAKAGURI SHINTARO, AIDA JUN, TAKEUCHI KENJI, ITO KANADE, NOGUCHI YUKI, OSAKA KEN

老年歯科医学　2011/09/30
一般住民の訪問歯科診療に対する認知に関する研究

SHIRAKAWA RIKIMARU, ITO KANADE, WAKAGURI SHINTARO, TAKEUCHI KENJI, AIDA JUN, OSAKA KEN

老年歯科医学　2011/09/30
高齢者における社会参加と残存歯数の関連

TAKEUCHI KENJI, AIDA JUN, OSAKA KEN, KONDO KATSUNORI

口腔衛生学会雑誌　2011/08/30
仮想評価法を用いた歯の健康に対する支払意思額と社会経済的地位との関連について

ITO SUSUMU, AIDA JUN, WAKAGURI SHINTARO, NOGUCHI YUKI, TAKEUCHI KENJI, OSAKA KEN

口腔衛生学会雑誌　2011/08/30
口腔保健とQOLの向上に関する総合的研究高齢者の口腔と全身の健康に影響する要因に関する研究

OSAKA KEN, TAKEUCHI KENJI, MATSUYAMA YUSUKE

口腔保健とQOLの向上に関する総合的研究平成22年度研究報告書　2011
思春期におけるフッ化物配合歯磨剤使用に関する意識調査

NOGUCHI YUKI, WAKAGURI SHINTARO, TAKEUCHI KENJI, ITO SUSUMU, AIDA JUN, OSAKA KEN

口腔衛生学会雑誌　2010/08/30
性・年齢階級別にみた歯科医師数の推移~医師・歯科医師・薬剤師調査を用いた分析~

TAKEUCHI KENJI, ANDO YUICHI, OUCHI AKITSUGU, FURUKAWA KIYOKA, OSAKA KEN

口腔衛生学会雑誌　2010/08/30
マルチレベル分析による親の喫煙行動と社会環境に関する研究

TAKEUCHI KENJI, AIDA JUN, MORITA MANABU, ANDO YUICHI, OSAKA KEN

J Epidemiol　2010/01/09

Show all Show first 5

Research Projects 41

Analysis of Oral and Cardiovascular Diseases Based on Real-World Data Including Metabolome and Claims Data

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2025/04/01 - 2030/03/31
A survey on health status and behavior among living alone and/or unmarried middle-aged individuals

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Nagoya University

2025/04 - 2028/03
Exploring evidence on the relationship between oral health, healthy life expectancy, and medical and long-term care cost reduction by utilizing big data

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2022/04/01 - 2027/03/31
機械学習を応用した異質介入効果に基づく健診事業のターゲティング・アプローチの開発

竹内研時, 研究分担者, 福田治久, 草間太郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的研究(萌芽)

Institution: 東北大学

2025/06 - 2027/03
妊娠期から学童期を紡ぐ保健・医療統合データベース基盤開発とエビデンス創出

福田治久, 研究分担者, 小川浩平, 石黒智恵子, 上村夕香理, 上田瑛美, 竹内研時, 森崎菜穂, 小野玲

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(A)

Institution: 九州大学

2024/04 - 2027/03
Exploring evidence on the relationship between oral health, healthy life expectancy, and medical and long-term care cost reduction by utilizing big data

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2022/04 - 2027/03
リアルワールドデータに基づく口腔の健康と健康関連QOLや労働生産性との関連に関する研究

竹内研時, 研究分担者, 福田治久, 田淵貴大, 草間太郎

Offer Organization: 厚生労働省

System: 厚生労働科学研究費補助金（循環器疾患・糖尿病等生活習慣病対策総合研究事業）

2024/04 - 2026/03
保健医療データベース利用による行動変容に向けたフィードバック手法の開発

福田治久, 研究分担者, 小野玲, 竹内研時

Offer Organization: 国立研究開発法人日本医療研究開発機構（AMED）

System: 循環器疾患・糖尿病等生活習慣病対策実用化研究事業

2023/11 - 2026/03
高齢者の笑顔を取り戻す：機械学習と自然実験を駆使した歯科からの挑戦

竹内研時, 研究分担者, 近藤克則, 大平哲也

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的研究(萌芽)

Institution: 東北大学

2023/06 - 2025/03
大規模コホートとリアルワールドデータを用いた口腔と全身疾患の関連についての研究

小坂健, 研究分担者, 相田潤, 葭原明弘, 岩崎正則, 財津崇, 大野幸子, 福田治久, 二宮利治, 古田美智子, 寳澤篤, 竹内研時

Offer Organization: 厚生労働省

System: 厚生労働科学研究費補助金（循環器疾患・糖尿病等生活習慣病対策総合研究事業）

2023/04 - 2025/03
Influence of Stress Resilience and Determinants of Resilience in the Development of Type 2 Diabetes in Japanese

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Nagoya University

2022/04 - 2025/03
Frailty prevention program for successful aging of rheumatoid arthritis patients

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: National Center for Geriatrics and Gerontology

2020/04 - 2025/03
保健・医療・介護・行政データを統合した大規模データベースを活用したワクチンの有効性・安全性の検証に資する研究開発

福田治久, 研究分担者, 小野玲, 勝田友博, 佐藤俊太朗, 石黒智恵子, 竹内研時

Offer Organization: 国立研究開発法人日本医療研究開発機構（AMED）

Category: ワクチン開発推進事業

2021/04 - 2024/03
プレシジョンメディシンに向けた口腔と循環器疾患についての遺伝と社会要因の解明

小坂健, 研究分担者, 竹内研時, 小山史穂子, 相田潤

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(B)

Category: 基盤研究(B)

Institution: 東北大学

2019/04 - 2024/03

More details Close

口腔衛生と認知機能低下の長期的な関連を調査するための無作為化試験の実施可能性は低いが、観察データから因果関係を導き出すことは困難である。我々は，観察されない時変因子の交絡効果を排除するために，固定効果モデルを用いて，口腔状態不良と主観的認知愁訴（SCC）の関連を調査することを目的とした。2010年，2013年，2016年に実施されたJapan Gerontological Evaluation Study（JAGES）のデータを使用した。口腔状態の悪化がSCC発症に及ぼす影響について，固定効果モデルを用いてβ回帰係数と95％信頼区間[CI]を算出した。SCCの発症は、キホンチェックリスト-認知機能スコアを用いて評価した。口腔内の状態は、嚥下困難の自覚、咀嚼機能の低下、ドライマウス、歯の本数の4つの変数を用いた。結果としてベースライン時にSCCを発症していない13,594人（女性55.8%）を対象とした。平均年齢は、男性72.4歳（標準偏差[SD]、5.1）、女性72.4歳（SD、4.9）であった。6年間の追跡期間中に、男性の26.6％、女性の24.9％がSCCを発症した。SCCの発症確率は、嚥下障害（β = 0.088; 95% CI, 0.065-0.111 for men and β = 0.077; 95% CI, 0.057-0.097 for women）、咀嚼機能低下（β = 0.039; 95% CI, 0.021-0.099; 95% CI, 0.057-0.097 for women）を獲得すると著しく高くなることが明らかになった。 057（男性）、β＝0.030（95％CI、0.013-0.046）、ドライマウス（β＝0.026（95％CI、0.005-0.048）、β＝0.064（95％CI、0.045-0.083）、歯の喪失（β＝0.043（95％CI、0.001-0.085）／男性）、β＝0.058（95％CI、0.015-0.102））であった。 結論この結果は、将来の認知症リスクを高めるSCCの発症を予防するために、良好な口腔衛生を維持する必要があることを示唆している。
歯科健診の効果検証の手法等に関する検証等一式

小坂健, 竹内研時

Offer Organization: 厚生労働省

System: 歯科健康診査推進事業

2022/12 - 2023/03
我が国の歯科口腔保健の実態把握を継続的・安定的に実施する手法の開発のための調査研究

田口円裕, 研究分担者, 竹内研時, 三浦宏子, 福田英輝, 篠崎智大, 古田美智子, 大島克郎, 石塚洋一, 田口千恵子

Offer Organization: 厚生労働省

System: 令和4年度厚生労働行政推進調査事業費補助金（厚生労働科学特別研究事業）

2022/07 - 2023/03
Elucidation of factors affecting oral microbiome development in early life stage

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Kyushu University

2020/04 - 2023/03
受動喫煙のバイオマーカーとしてのコチニンと幼児・学童のう蝕の関連についての研究

後藤拓朗, 研究分担者, 古田美智子, 竹内研時, 竹下徹, 山下喜久

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 九州大学

2020/04 - 2023/03

More details Close

受動喫煙が健康へ悪影響を及ぼすことは多くの研究で報告されている。小児期における受動喫煙は、両親の家庭内における喫煙が原因となっていることが多く、小児は自ら受動喫煙を回避することが困難であるため、健康被害を受けやすい。受動喫煙の客観的指標として、ニコチンの代謝産物であるコチニンの測定が有効であることが知られているが、小児の唾液中に排出されるコチニン濃度とう蝕の関連性に関する報告は少ない。本研究では、小学1年生における唾液中のコチニン濃度と受動喫煙状況、う蝕の発症の関連性を明らかにすることを目的とした。学校歯科健康診断を受診した小学校1年生92名を対象とした。口腔内診査は歯科医師が行い、同時にアンケートと唾液の採取を行った。アンケートでの喫煙回答は、両親喫煙、母親のみ喫煙、父親のみ喫煙、両親非喫煙に分類した。未処置歯数と処置歯数（DF歯数）は、乳歯DF歯数と永久歯DF歯数の合計とした。アンケートでは性別、間食回数、フッ素の歯磨き剤使用、歯科医院の定期受診の有無についても評価した。唾液中コチニン濃度はELISA法にて測定し、受動喫煙状況、DF歯数との関連を検討した。唾液中コチニン濃度は、両親喫煙、母親のみ喫煙と回答した者において有意に高かった。DF歯数を従属変数として負の二項分布モデルで解析した結果、DF歯数とコチニン濃度に関連性がみられた。小学生の唾液中コチニン濃度と受動喫煙状況、DF歯数に関連性がある可能性が示唆された。
歯科口腔保健の推進に資するう蝕予防のための手法に関する研究

相田潤, 研究分担者, 晴佐久悟, 濃野要, 竹内研時, 磯﨑篤則, 荒川浩久, 石塚洋一, 古田美智子, 松山祐輔, 廣瀬晃子

Offer Organization: 厚生労働省

System: 令和3年度厚生労働行政推進調査事業費補助金（地域医療基盤開発推進研究事業）

2021/04 - 2022/03
Clarification of the relationship between periodontitis severity and the onset and progression of chronic obstructive pulmonary disease

Takeuchi Kenji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Nagoya University

2019/04 - 2022/03

More details Close

This study examined whether periodontal disease could be a risk factor for the development and progression of COPD in an average Japanese population, adults 40 years of age and older living in the town of Hisayama, taking into account the effects of various covariates, such as smoking. The results showed that the severity of periodontal disease was consistently associated with airflow obstruction, a typical precursor symptom of COPD, throughout the 10-year study period. It was also found that periodontal disease was associated with the risk of developing new COPD, particularly among those with severe periodontal disease, who had an approximately 3-fold higher risk of developing COPD after 5 years compared to those with healthy or mild periodontal disease. On the other hand, no significant association was found between the severity of periodontal disease and severe COPD or percent predicted forced expiratory volume in one second, one of the COPD severity indicators.
慢性閉塞性肺疾患（COPD）の発症・進行に対する歯周病の重症度の影響の解明 Competitive

竹内研時, 研究分担者, 松元幸一郎, 古田美智子

Offer Organization: 文部科学省

System: 科学研究費補助金(基盤研究(C))

2019/04 - 2022/03
高齢者の口腔機能と施設入所・死亡との関係に関する地域疫学研究ー日常生活に環境と習慣（人と人とのつながり・発声頻度・咀嚼）は予後に影響を与えるかー

永吉真子, 研究分担者, 竹内研時, 前田隆浩

Offer Organization: 公益財団法人8020推進財団

System: 令和2年度8020公募研究課題

2020/04 - 2021/03
Oral health and male-female health-survival paradox

Furuta Michiko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kyushu University

2018/04 - 2021/03

More details Close

Gender difference in abnormal aging may result in male-female health-survival paradox. Oral health is potentially associated with abnormal aging. This study aimed to investigate the gender difference between oral health and abnormal aging which is represented by advanced glycation end products (AGEs). This study focused on soluble receptor for AGEs (sRAGE) which could prevent the adverse effects of RAGE signaling by acting as a decoy. Levels of sRAGE was lower in males than in females. Low levels of sRAGE in plasma were associated with tooth loss in males. Gender difference in oral condition may be related to that in levels of sRAGE.
口腔の健康から健康長寿をめぐる性差パラドックスの解明を目指す研究 Competitive

古田美智子, 研究分担者, 竹内研時, 山下喜久, 二宮利治

Offer Organization: 文部科学省

System: 科学研究費補助金(基盤研究(C))

2018/04 - 2021/03
Platform of Supporting Cohort Study and Biospecimen Analysis

MURAKAMI Yoshinori, IMAI Kohzoh, TANAKA Hideo, WAKAI Kenji, MURAYAMA Shigeo, DAIGO Yataro, TAKEUCHI Kenji, MATSUO Keitaro, MIKAMI Haruo, NAKAMURA Yohko, SUZUKI Sadao, KITA Yoshikuni, WATANABE Yoshiyuki, UEHARA Ritei, KOYAMA Teruhide, TANAKA Keitaro, TAKEZAKI Toshiro, NAITO Mariko, KURIKI Kiyonori, FURUSHO Norihiro, OHNAKA Keizo, MURATA Masayuki, ARISAWA Kokichi, TAMAKOSHI Akiko, MORI Mitsuru, KAWASAKI Ryo, KONTA Tsuneo, TAKEBAYASHI Toru, MIURA Katsuyuki, NARIMATSU Hiroto, SUZUKI Kouji, NAKATOCHI Masahiro, SHIMIZU Atsushi, TAKAO Masaki, AKATSU Hiroyasu, KANEDA Daita, SAITO Yuko, YABE Hirooki, MIHARA Ban, IMOTO Issei, MIYAGI Youhei, WATANABE Toshiki, YASUI Hiroshi, ISHIKAWA Fuyuki, HINO Okio, TAKANO Atsushi, TERAMOTO Koji, MATSUDA Kouichi, AOKI Ichiro, YANAGISAWA Kiyoshi, OHASHI Kenichi, FUJII Satoshi, TOUJHOU Arinobu, UCHIMARU Kaoru, TANAKA Yukichi, YOKOSE Tomoyuki, KAWASAKI Takashi, SHIBATA Wataru, YATABE Yasushi, ORIME Kazuki, TAKAHASHI Takashi, TAGUCHI Ayumu, YAMAGUCHI Rui, SATO Shinya, TAJIRI Michihiko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources

Category: Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources

Institution: The University of Tokyo

2016 - 2021

More details Close

Biomedical research is shifting its paradigm from molecular, cellular and animal-model analysis to human research. Now, comprehensive or validation studies on human materials become essential for understanding of their biomedical significance and for their clinical applications. Thus, based on the collaboration of scientists in Japan, a platform was constructed to collect, store, and provide materials with informed consent from cohorts of around 135,000 healthy individuals, around 300 brain tissues from autopsy, and around 114,000 clinical specimens, as well as cutting-edge analytical techniques of human materials. Then, in 6 years, this platform supported 4,997 projects and contributed to the publishment of 882 scientific articles, including state-of-the-art studies published in various top journals. This platform also encouraged interdisciplinary sciences through workshops for young scientists and cultivated human resources who devoted themselves to support activities.
口腔の健康と全身の健康の関連の文献レビューと因果推論手法の提案 Competitive

相田潤, 研究分担者, 大野幸子, 竹内研時, 山田聡, 小坂健

Offer Organization: 厚生労働省

System: 令和元年度厚生労働行政推進調査事業費補助金（循環器疾患・糖尿病等生活習慣病対策総合研究事業）

2019/08 - 2020/03
歯の喪失予防と義歯利用が高齢者の笑って暮らせる生活の維持に果たす役割の検討 Competitive

竹内研時, 研究分担者, 近藤克則

Offer Organization: 公益財団法人8020推進財団

System: 令和元年度8020公募研究課題

2019/04 - 2020/03
Identification of oral health-related risk factors for development of dementia

Takeuchi Kenji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Kyushu University

2017/04/01 - 2019/03/31

More details Close

This study clarified oral-related risk factors contributing to the onset and progression of dementia in a community-dwelling adults aged 65 years or over in Hisayama town, adjusting for potential confounders. Salivary oxidative stress markers in Alzheimer's disease patients were significantly lower than those in healthy controls. In linear regression models, tooth loss was significantly positively associated with global brain atrophy, but not hippocampal atrophy, one of the morphological features of Alzheimer's disease.
かかりつけ歯科医の性別による患者の歯科保健行動の違いの検討 Competitive

竹内研時

Offer Organization: 公益財団法人富徳会

System: 平成30年度研究助成金（口腔衛生学部門）

2018/04 - 2019/03
認知症の発症・進行に寄与する口腔関連リスク因子の解明 Competitive

竹内研時

Offer Organization: 文部科学省

System: 科学研究費補助金(若手研究(B))

2017/04 - 2019/03
A large-scale survey of tongue microbiota of elderly adults for the development of its maintenance approach

Takeshita Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Kyushu University

2016/04 - 2019/03

More details Close

Tongue microbiota is a primary source of microbial populations that are ingested with saliva. Therefore, careful attention is needed for the health maintenance in elderly adults, because they are susceptible to aspiration of oral contents. This study determined the microbial composition of elderly adults based on a comprehensive microbial community analysis using microbial DNA with a large sample size. We revealed variations in the tongue microbiota composition among community elderly adults, as well as a dysbiotic pattern associated with pneumonia-related death in the frail elderly adults. Our results would be a basis for the development a novel health maintenance approach of elderly adults targeting their tongue microbiota.
Health factors among elderly people in low-class healthy life expectancy: interregional comparison

Noguchi Yuki, Takeuchi Kenji, Ojima Toshiyuki, Okada Eisaku, Inaba Youji, Aida Jun

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: University of Shizuoka,Shizuoka College

2016/04 - 2019/03

More details Close

Healthy life expectancy for elderly people living in the longest regions was 3 years longer than for those living in the shortly regions. This study compared the lifestyle and social support between two populations: low-class and top-class (Morimachi Study) healthy life expectancy. We investigate regional differences in healthy life expectancy. In this study, the subjects were 2,000 among elderly people living in low-class healthy life expectancy, Japan. The subjects completed the self-administered questionnaire consisting of their self-reported education, income, region, health status, smoking, drinking, lifestyle, health behaviors, social support. Morimachi Study was conducted in the same way. The result suggested that low-class healthy life expectancy could have some impact on the hypertension.
舌苔の病原性評価ガイドラインの策定に向けた基盤マイクロバイオームデータの構築 Competitive

竹下徹, 研究分担者, 竹内研時, 山下喜久, 古田美智子, 二宮利治

Offer Organization: 文部科学省

System: 科学研究費補助金(基盤研究(B))

2016/04 - 2019/03
費用対効果の高い歯科保健サービスの提供方法・内容の分析 Competitive

山下喜久, 研究分担者, 竹内研時, 古田美智子, 須磨紫乃

Offer Organization: 厚生労働省

System: 厚生労働科学研究費補助金

2016/11 - 2017/03
Research for relationship between oral microboiome and head and neck and digestive organ cancers

Yamashita Yoshihisa, TOU Yasushi, MORITA Masaru, MASUDA Muneyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Kyushu University

2015/04 - 2017/03

More details Close

The purpose of this study is the characterization of the oral microbiome related to head and neck, digestive organ cancer. Saliva was collected from the patients who had a diagnosis of head and neck cancer or a digestive organ cancer in National Hospital Organization Kyushu Cancer Center. Salivary microbiome was analyzed with the next-generation sequencer. The results were compared with those of the salivary microbiome of dwelling population at Hisayama town to aim the identification of a special microbe or the unique constitution pattern to cancer patients. As a result, the salivary microbiome constitution peculiar to the patients of head and neck, digestive organ cancer was not recognized, but the constituent ratio of some bacterial species was significantly different between a cancer patients and non-cancer dwelling population.
Elucidation of the actual situation and the risk factor of the human papilloma virus infection involved in the oral cavity, pharynx cancer Competitive

Takeuchi Kenji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Kyushu University

2015/04 - 2017/03

More details Close

This study estimated the prevalence of high-risk human papillomavirus (HPV) infection and determined distinct risk factors for high-risk HPV infection in a community-dwelling adults aged 40-69 years. Among 574 respondents (269 men and 305 women), high-risk HPV infection was found in 25 respondents (4.4%). In a multivariate logistic regression model, higher plaque score was significantly associated with greater odds of high-risk HPV infection (plaque score >1, odds rario = 3.49, 95% confidence interval= 1.24-9.81). These findings suggest that plaque score is an important predictor of high-risk HPV infection and maintenance of oral hygiene may contribute to prevention of oral cavity, pharynx cancer in Japanese adults.
The effect of local community cooperation on prevention of dental caries in children by Sociometry analysis

Hironaka Mikiko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kyushu University

2013/04 - 2017/03

More details Close

This study examined the effect of community characteristics and community health program on dental caries in children, considering health behavior as individual characteristics. The data of medical and dental examination for one and half years old and three years old was used. We explored the factor of increasing dental caries in children with and without dental caries, aged one and half years. This study indicates that fluoride application as community health program is more likely to prevent dental caries in children without dental caries than those who have dental caries.
Oxytocin, social capital, and oral health related QOL

AIDA Jun, OSAKA Ken, KONDO Katsunori, MATSUYAMA Yusuke, KOYAMA Shihoko, TAKEUCHI Kenji, HASE Akihiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2013/04/01 - 2015/03/31

More details Close

Oxytocin is a peptide hormone. It plays an important role on social behaviors of humans. In recent years, Social capital has drawn increased attention as a key factor in relation to health, and oxytocin may be an underlying biomarker. Oral health is associated with social relationships through oral health function on conversation, eating, and facial appearance. We examined the association of oxytocin on sociality and oral health. As the results, weak associations were partially observed. Social function of oral health may be associated with improvement of sociality and oxytocin secretion volume.
Effects of social determinants before- and after- the disaster on oral and general health

AIDA Jun, OSAKA Ken, KONDO Katsunori, MATSUYAMA Yusuke, KOYAMA Shihoko, SATO Yukihiro, TAKEUCHI Kenji, ITO Kanade, HASE Akihiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2012/04/01 - 2015/03/31

More details Close

A huge disaster causes change of social determinants of health, which damage health of victims. However, few studies examine the effect of social determinants on physical, not only mental, health after a huge disaster. Our cohort study investigated the association between disaster-related economic difficulty and health among older victims of the Great East Japan Earthquake in 2011. After considering covariates, disaster-related economic difficulty was significantly associated with tooth loss. Loss of social relationships was significantly associated with deterioration of mental health. Psychological stress caused by various social factors after disasters may affect health of victims.
誤嚥性肺炎の予防に繋がる咳嗽力の維持・向上を目指した口腔ケアの検討 Competitive

泉繭依, 研究分担者, 山下喜久, 竹内研時

Offer Organization: 公益財団法人8020推進財団

System: 平成26年度8020公募研究課題

2014/04 - 2015/03
Serum antibody to Porphyromonas gingivalis and periodontitis progression: a prospective cohort study Competitive

TAKEUCHI KENJI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

Category: Grant-in-Aid for Research Activity Start-up

Institution: Kyushu University

2013/08 - 2015/03

More details Close

This prospective cohort study assessed the effectiveness of serum titers of antibody to Porphyromonas gingivalis in the prediction of periodontitis progression in 183 Japanese individuals (75 men and 108 women) aged 40-49 years. Periodontitis progression, defined as a progression in attachment loss of 3 mm or greater at 2 or more measurement sites during the 4-year follow-up period, was found in 8.7% subjects. In a multivariate logistic regression model, higher titers of antibody to Porphyromonas gingivalis and male gender were significantly associated with greater odds of periodontitis progression, even after adjustment for other confounding variables (titers of antibody to Porphyromonas gingivalis per 10 units: odds Ratio, 1.66; 95% confidence interval, 1.16-2.36; male gender: odds ratio, 4.13; 95% confidence interval, 1.20-14.27). These findings suggest that elevated serum titers of antibody to Porphyromonas gingivalis may be a risk factor for periodontitis progression.

Show all Show first 5

Teaching Experience 33

Lectures in Dental Statistics: Social Dentistry　Tohoku University
社会疫学（疫学各論）　名古屋大学 Undergraduate (specialized)
Seminars in Dental Sciences: International Oral Health　Tohoku University Postgraduate
Lectures in Dental Sciences: International Oral Health　Tohoku University Postgraduate
Technical Courses in Dental Sciences: International Oral Health　Tohoku University Postgraduate
Basic Technical Courses in DentalSciences: Dental Public Health　Tohoku University Postgraduate
医療保障と歯科（社会歯科学）　東北大学 Undergraduate (specialized)
公衆衛生学　仙台医健・スポーツ専門学校
The burden of oral health problems in older adults (The 12th World Prestigious Scholar Lecture Series)　Seoul National University School of Dentistry Other
Social EpidemiologyーThe Link between Oral and General Healthー　Sichuan University & Tohoku University Other
予防医学　名古屋大学 Postgraduate
Healthcare Administration (Young Leaders' Program)：Epidemiology　Nagoya University Postgraduate
Healthcare Administration (Young Leaders' Program)：Biostatistics　Nagoya University Postgraduate
基礎医学セミナー　名古屋大学 Undergraduate (specialized)
遺伝疫学（社会医学実習）　名古屋大学 Undergraduate (specialized)
口腔領域の疫学（疫学各論）　名古屋大学 Undergraduate (specialized)
分析疫学（疫学総論）　名古屋大学 Undergraduate (specialized)
スクリーニング（予防）　名古屋大学 Undergraduate (specialized)
記述疫学と疫学指標（疫学総論）　名古屋大学 Undergraduate (specialized)
疾患予防と健康施策（予防）　名古屋大学 Undergraduate (specialized)
環境衛生学　九州大学 Undergraduate (specialized)
口腔保健学　九州大学 Undergraduate (specialized)
歯学総論Ⅱ　九州大学 Undergraduate (specialized)
アーリーエクスポージャⅡ　九州大学 Undergraduate (specialized)
リサーチエクスポージャ　九州大学 Undergraduate (specialized)
総合歯科学　九州大学 Undergraduate (specialized)
口腔予防医学　九州大学 Postgraduate
口腔衛生学　福岡歯科衛生専門学校
歯科衛生統計学　博多メディカル専門学校
口腔微生物学　九州大学 Undergraduate (specialized)
口腔環境保健学Ⅱ　九州大学 Undergraduate (specialized)
口腔環境保健学Ⅰ　九州大学 Undergraduate (specialized)
歯科衛生統計学　山形歯科専門学校

Show all Show first 5

Social Activities 15

歯科疾患の疾病負担への理解と対策：ギャップを埋め，視野を広げる

歯科保健医療提供体制の在り方について考える集い

2025/12/10 -
データから探る成人期の歯科口腔保健施策の意義

令和6年度江戸川区８０２０運動推進勉強会

2025/01/29 -
歯科の立場から考える認知症予防

学術交流研修会

2024/10/29 -
歯周疾患検診の対象に20歳・30歳が追加された背景と若年層対策

令和6年度第2回愛知県歯科衛生士人材育成研修

2024/08/19 -
口腔機能と全身の健康とのつながり

令和5年度江戸川区８０２０運動推進勉強会

2024/01/26 -
なるほど・なっとく・たのしい疫学・統計

令和5年度第3回愛知県歯科衛生士人材育成研修

2023/12/26 -
笑って長生きするには、歯医者に行こう～笑いの健康効果と口との繋がり～

社内⻭科公開講座

2023/11/13 -
疫学・統計の実践編Ⅱ～事例から学ぶアンケート集計・分析～

令和4年度第3回愛知県歯科衛生士人材育成研修

2022/12/26 -
今、改めて考えるう蝕予防の重要性

ライオン大学院

2022/08/19 -
疫学・統計の実践編～事例から学ぶアンケート集計・分析～

令和3年度第３回愛知県歯科衛生士人材育成研修

2021/12/27 -
地域保健活動における統計・疫学の基礎と実践

令和2年度第３回愛知県歯科衛生士人材育成研修

2020/12/18 -
地域歯科保健活動における統計・疫学の基礎知識

令和2年度医療圏代表者会議研修会

2020/11/19 -
地域保健活動における統計・疫学の基礎知識

令和元年度第２回愛知県歯科保健課題対応研修

2019/11/06 -
知って得する！健口情報

平成30年度生活習慣病予防月間歯科講演会

2019/02/14 -
お口の健康と全身の健康の関係

平成28年度特定保健指導従事者研修会

2017/01/26 -

Show all Show first 5

Media Coverage 49

歯の本数と死因別死亡の関連を検証、入れ歯使用でリスクが減弱か——4.4万人の7年追跡研究残存歯が少ないほど複数の死因で死亡率が高まり、補綴物の使用でそのリスクが弱まる可能性

m3.com　臨床ニュース

2026/02/11

Type: Internet
歯の本数と死因別死亡の関連を検証、入れ歯使用でリスクが減弱か——4.4万人の7年追跡研究

ケアネット

2026/01/15

Type: Internet
数字で見る「歯」の最新情報。大人の虫歯が増加傾向にあり？

Yahoo! JAPAN　Yahoo!ニュース

2026/01/10

Type: Internet
入れ歯は死亡リスクを下げるって本当？「歯の本数」と「死亡率」の関連性

小学館　@DIMEアットダイム

2026/01/09

Type: Internet
歯の本数と死因別死亡の関連を検証、入れ歯使用でリスクが減弱か——4.4万人の7年追跡研究

株式会社Buzzreach　smt

2026/01/05

Type: Internet
寒い住宅抑うつリスクも

朝日新聞社　朝日新聞　ぶらっとラボ

2025/11/17

Type: Newspaper, magazine
健康寿命は、歯が決める!

マガジンハウス　Tarzan（ターザン）No. 913（2025年11月13日号）　お口にまつわる最新トピックス。（P12~15）;歯と健康の深すぎる関係。（P16～19）

2025/10/23

Type: Newspaper, magazine
日本の高齢者データが示す、室内温度と抑うつ症状の関連性

ケアネット

2025/10/16

Type: Internet
Frequent laughter linked to lower risk of depression in older adults

2025/10/15

Type: Internet
笑わないから「うつ」なのか、「うつ」だから笑わないのか？

Forbes JAPAN　Web-News

2025/10/05

Type: Internet
「高齢者が憂うつになる家」の決定的な特徴

ダイヤモンド社　ダイヤモンド・オンライン

2025/10/04

Type: Internet
実は関連性があった？高齢者の「抑うつ症状」と「室内温度」

小学館　@DIMEアットダイム

2025/10/01

Type: Internet
糖尿病患者は……歯周病治療をすべし

毎日新聞社　毎日メディカル

2025/08/06

Type: Internet
奥歯の咬合不全でCVDリスク25～31％増

メディカルトリビューン

2025/05/27

Type: Internet
歯周病治療で糖尿病患者における人工透析リスクが低下か

m3.com　臨床ニュース

2025/05/09

Type: Internet
歯周病治療で糖尿病患者における人工透析リスクが低下か

ケアネット

2025/03/12

Type: Internet
糖尿病患者こそ歯周病の治療をしたほうがいい理由

小学館　@DIMEアットダイム

2025/03/11

Type: Internet
歯周病かつ糖尿病だと年間医療費が1.3倍／東北大研究で

日本歯科新聞

2025/02/06

Type: Newspaper, magazine
歯科受診で介護コストが抑制される可能性――日本老年学的評価研究

m3.com　国際医学短信

2025/01/02

Type: Internet
「予防目的で歯医者に行っている高齢者は介護費用が11万円低い」東北大大学院研究グループの調査で判明

小学館　介護ポストセブン

2024/11/19

Type: Internet
「未来の歯産価値を、今からつくる。＃投歯」PJ始動歯科健診の有無が、将来的な医療費・介護費に影響

共同通信　PRワイヤー

2024/11/07

Type: Internet
歯科受診で介護費用を1000ドル削減！～予防歯科診療の重要性～

m3.com　ドクター寄稿

2024/11/06

Type: Internet
歯科受診で介護コストが抑制される可能性―日本老年学的評価研究

ケアネット

2024/10/31

Type: Internet
介護コストが抑えられる？予防目的で歯医者を受診し続けると得をする理由

小学館　@DIMEアットダイム

2024/10/29

Type: Internet
週１回以上笑って健康に～友人と交流で効果アップ～

時事メディカル

2024/04/19

Type: Newspaper, magazine
ワハハと笑って介護予防人生の目標に

産経新聞

2023/12/25

Type: Newspaper, magazine
どんな笑いが健康リスクを減少させる？

メディカルトリビューン

2023/11/27

Type: Internet
新型コロナで減った「笑い」回復の鍵は？

メディカルトリビューン

2023/10/19

Type: Internet
低学歴・低収入ほどたばこで病気に？喫煙が「格差問題」と化した理由

ダイヤモンド社　ダイヤモンド・オンライン

2023/03/09

Type: Internet
Lower the risk of bad health by laughing with others, says research

2022/10/19

Type: Newspaper, magazine
加熱式たばこによる受動喫煙への曝露状況を調査

株式会社法研　へるすあっぷ２１

2022/07/01

Type: Promotional material
ジャーナル医療健康誰かと笑うと要介護リスクが減る！？

NHK　NHKジャーナル

2022/05/17

Type: TV or radio program
友人などと笑うと要介護リスクが減少東北大などの研究

NHK東北版　NHK NEWS

2022/05/09

Type: TV or radio program
友人などと一緒に笑う高齢者要介護リスク低くなる東北大など

NHK　NEWS WEB

2022/05/06

Type: Internet
研究結果誰かと一緒に笑うと要介護のリスクが減少

NHK東海版　ニュース番組「まるっと！」

2022/05/06

Type: TV or radio program
特別企画日本口腔衛生学会学会声明『生涯28』の科学的根拠について考える

歯界展望 2021年4月号（137巻4号）　歯の喪失の歯科・医科医療費への影響

2021/03/26

Type: Newspaper, magazine
with コロナの口腔予防管理

歯界展望 2021年3月号（137巻3号）

2021/02/26

Type: Newspaper, magazine
笑って減らそう要介護リスク笑わない人は毎日笑う人の1・4倍も危険／運動より簡単誰でもできる！

週刊朝日 2020年11月13日号

2020/11/04

Type: Newspaper, magazine
もっと笑いたい発声で心身リラックス

毎日新聞人生100年クラブ

2020/10/11

Type: Newspaper, magazine
本当だった？「笑う門には福来たる」介護リスクへの影響、名古屋大が初の大規模調査

毎日新聞

2020/09/13

Type: Internet
笑わない人ほど要介護リスク高くよく笑う人の1.4倍

朝日新聞

2020/08/04

Type: Newspaper, magazine
笑わない高齢者介護必要になるリスク1.4倍に名古屋大など

NHK　おはよう日本

2020/07/16

Type: TV or radio program
新型コロナウイルス感染拡大下における一般住民の歯科医院受診に関する意識調査

ザ・クインテッセンス 2020年7月号

2020/06/17

Type: Newspaper, magazine
病気になる社会的要因を探る

朝日新聞先端人

2020/04/19

Type: Newspaper, magazine
歯周病でＣＯＰＤリスク３・５倍喫煙しなくても危険

朝日新聞

2019/04/10

Type: Newspaper, magazine
肺の健康を守るには口の健康から。歯周病が呼吸機能低下を引き起こす。

Dentalism 2018 Winter Vol. 33 Dentalism News & Topics

2018/12/01

Type: Newspaper, magazine
非喫煙でも「たばこ病」に歯周病でリスク上昇

朝日新聞

2018/11/06

Type: Newspaper, magazine
医局紹介：研究プロジェクトの精鋭たち医局のエース紹介

ザ・クインテッセンス 2018年5月号

2018/05/10

Type: Newspaper, magazine
「歯は大切に」認知症発症にも影響：久山町研究

ケアネット

2017/04/10

Type: Internet

Show all Show first 5

Academic Activities 3

日本口腔衛生学会・COVID-19対策緊急アンケート結果速報

2020/05/19 -

Activity type: Other
委員会報告: 「口腔保健の新定義」に関する動向

2017/10/30 -
The preventive role of oral health against dementia

2017/05/31 -

Other 7

日本口腔衛生学会専門医

More details Close

認定年月日：2022年1月1日（番号：50）
日本口腔衛生学会指導医

More details Close

認定年月日：2021年1月1日（番号：75）
日本疫学会上級疫学専門家

More details Close

認定年月日：2020年4月1日（番号：CSE 20-179）更新年月日：2025年4月1日（番号：CSE 25-20179）
口腔衛生学会若手の会世話人
日本口腔衛生学会認定医

More details Close

認定年月日：2015年3月2日（番号：463）
若手の会（疫学の未来を語る若手の会）世話人

More details Close

2020年4月以降は代表幹事（広報担当） https://jeaweb.jp/youth/index.html
J-MICC研究（日本多施設共同コーホート研究）中央事務局長

Show all Show first 5