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Kyosuke Ueda

Section

Graduate School of Engineering

Job title

Associate Professor

Degree

博士（工学）（東北大学）
修士（工学）（東北大学）

researchmap

https://researchmap.jp/read0158324

J-GLOBAL ID

200901008476040328

e-Rad No.

40507901

ORCID

https://orcid.org/0000-0001-7166-8727

Research History 5

2021/04 - Present

Hachinohe National College of Technology
2016/04 - Present

Tohoku University　Graduate School of Engineering Department of Materials Processing　Asociate Professor
2019/08 - 2020/08

Imperial College London　Department of Materials　Visiting Researcher
2008/04 - 2016/03

Tohoku University　Graduate School of Engineering Department of Materials Processing　Assistant Professor
2005/04 - 2008/03

JSPS　特別研究員(DC1)

Education 3

Tohoku University　Graduate School of Engineering　Department of Materials Processing

2005/04 - 2008/03
Tohoku University　Graduate School, Division of Engineering　Department of Metallurgy

2003/04 - 2005/03
Tohoku University　Faculty of Engineering　Department of Metallurgy

1999/04 - 2003/03

Committee Memberships 9

軽金属学会　編集委員

2025/05 - Present
日本チタン学会　監事

2021/06 - Present
軽金属学会　企画委員

2017/08 - Present
日本金属学会　分科会委員

2017/04 - Present
日本バイオマテリアル学会　評議委員

2015/11 - Present
日本金属学会　会報編集委員

2013/04 - Present
日本バイオマテリアル学会シンポジウム2024　組織委員

2023/10 - 2024/11
軽金属学会　東北支部幹事

2015/04 - 2019/03
日本バイオマテリアル学会シンポジウム2012　大会実行委員

2012/04 - 2012/11

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Professional Memberships 6

The Japan Institute of Titanium

2022/04 - Present
JAPANESE SOCIETY FOR BONE MORPHOMETRY
Japan Society of Powder and Powder Metallurgy
The Japan Institute of Light Metals
Japanese Society for Biomaterials
The Japan Institute of Metals

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Research Interests 5

貴金属
noble metal
surface modification
calcium phosphate
titanium alloy

Research Areas 3

Nanotechnology/Materials / Material fabrication and microstructure control /
Life sciences / Biomaterials /
Life sciences / Biomedical engineering /

Awards 12

第23回軽金属躍進賞

2024/11　一般社団法人軽金属学会　軽元素に着目した生体用チタン合金開発およびチタンへの抗菌機能付与
第82回日本金属学会功績賞

2024/03　公益財団法人日本金属学会　バイオセラミックスを利用した金属系材料の表面創製および血管治療用合金開発・プロセス構築に関する研究
第41回本多記念研究奨励賞

2020/11　The Honda Memorial Foundation　生体に適した金属材料の微細組織および表面の創製
The Japan Institute of Metals and Materials Murakami Young Researcher Award

2020/09　The Japan Institute of Metals and Materials　金属系材料の生体応用に向けた表面および組織創製プロセスの開発
第34回軽金属奨励賞

2016/11/05　一般社団法人軽金属学会　チタン系生体用金属材料の高機能化
第55回原田研究奨励賞

2015/07　公益財団法人本多記念会　生体吸収性非晶質リン酸カルシウムコーティングによる金属系バイオマテリアルの骨適合性向上に関する研究
第25回トーキン科学技術振興財団

2015/03　公益財団法人トーキン科学技術振興財団　生体吸収性非晶質リン酸カルシウムコーティングによるチタンの骨適合性向上に関する研究
Best Poster Presentation

2012/11/06　The 5th International Symposium on Designing, Processing and Properties of Advanced Engineering Materials ISAEM-2012
(社)日本金属学会第21回奨励賞

2011/11/06　(社)日本金属学会　材料化学部門
Award for Incouragement of Research of Materials Science

2007/12/09　The Materials Research Society of Japan　In Vitro and In Vivo Evaluation of Amorphous Calcium Phosphate Films on Titanium using RF Magnetron Sputtering
第111回東北大学金属材料研究所所内講演会最優秀ポスター賞

2006/05　東北大学金属材料研究所　リン酸カルシウムスパッタリング膜の生成相と生体吸収性の関係
第1回日本金属学会優秀ポスター賞

2003/10　(社)日本金属学会　擬似体液中におけるステンレス鋼およびチタン合金の界面反応

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Papers 170

Citric acid-assisted sol–gel synthesis of highly reactive borate-based bioactive glass powders

Jun Rey Sullano Lincuna, Kyosuke Ueda, Takayuki Narushima

Journal of Non-Crystalline Solids　2025/10

DOI： 10.1016/j.jnoncrysol.2025.123637 　
Laser-beam powder bed fusion followed by laser-induced periodic surface structuring leads to antibacterial properties

Liwei Chen, Hiroyasu Kanetaka, Maiko Furuya, Kotone Yokota, Kyosuke Ueda, Naoki Takano, Masayoshi Mizutani

Materials & Design　2025/06

DOI： 10.1016/j.matdes.2025.114078 　
Co-Cr-W-Pt alloys with high X-ray visibility for next-generation balloon-expandable stents

Tomoki Nakajima, Yuri Ito, Kosuke Ueki, Tomokazu Numano, Kyosuke Ueda, Takayuki Narushima

Materials Science and Engineering: A　2025/06

DOI： 10.1016/j.msea.2025.148216 　
Antibacterial properties of TiO2 layers formed by Au-sputtering and thermal oxidation of titanium under visible light Peer-reviewed

T. Ueda, R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, H. Kanetaka, T. Narushima

J. Jpn. Inst. Metals and Mater.　88　(12)　314-323　2024/12

DOI： 10.2320/jinstmet.JC202405 　
Preface to Special Issue on Research Frontiers in Materials Interfaces in Contact with “Biological Environment”

Ikeo Naoko, Ueki Kousuke, Ueda Kyousuke, Kozasa Ryousuke, Hakamada Masataka, Matsugaki Aira, Yamanaka Kenta, Lee Sungho

Materia Japan　63　(9)　605-605　2024/09/01
Publisher: The Japan Institute of Metals and Materials
DOI： 10.2320/materia.63.605 　

ISSN： 1340-2625

eISSN： 1884-5843
Exceptional balance of strength and ductility in biomedical Co–Cr–W–Ni alloy with added carbon

Sukma Suci Friandani, Kai Hiyama, Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima

Materials Science and Engineering: A　908　146722-146722　2024/08
Publisher: Elsevier BV
DOI： 10.1016/j.msea.2024.146722 　

ISSN： 0921-5093
Probing plastic deformation-related properties in static recrystallized Co–Cr–Fe–Ni–Mo alloy for biomedical applications

Kai Hiyama, Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima

Materials Science and Engineering: A　899　146458-146458　2024/05
Publisher: Elsevier BV
DOI： 10.1016/j.msea.2024.146458 　

ISSN： 0921-5093
Systematic study on the microstructures of biomedical Co-20Cr-15W-10Ni alloys with carbon contents ranging from 0 to 0.2 mass pct Peer-reviewed

S.S. Friandani, K. Ueda, T. Narushima

Metall. Mater. Trans. B　55　1011-1024　2024/03

DOI： 10.1007/s11661-024-07300-3 　
Improvement of Work-Hardening Behavior of Co-Cr-W-Ni Alloy by Adding Mn/Fe for Balloon-Expandable Stents

Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Key Engineering Materials　967　115-120　2023/12/05
Publisher: Trans Tech Publications, Ltd.
DOI： 10.4028/p-ervq7v 　

eISSN： 1662-9795

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The Co-20Cr-15W-10Ni (CCWN, mass%) alloy, registered as American society of testing and materials (ASTM) F90, has been widely used as a balloon-expandable stent because of its excellent balance between its mechanical properties and corrosion resistance. To realize a less invasive stent placement, the stent diameter must be reduced, which implies that the stent strut thickness must be reduced. As such, the CCWN alloy must be high in strength and ductility while maintaining a low yield stress to facilitate the expansion and suppression of stent recoil. In this study, we focus on the effects of the adding Mn/Fe on the microstructure, mechanical properties, and corrosive properties of CCWN alloys. A 6 mass% Mn-added CCWN alloy with a grain size of approximately 20 μm prepared in this study exhibits excellent balance between tensile strength and ductility. In addition, it exhibits a lower yield stress while maintaining a high tensile strength compared with the ASTM F90 alloy. Meanwhile, a 6 mass% Fe-added CCWN alloy exhibits a higher ductility compared with the ASTM F90 alloy. The addition of Mn or Fe to the CCWN alloy increases the stacking fault energy of the alloy and suppresses strain-induced martensitic transformation during plastic deformation, thus improving the ductility of the alloy. Results of polarization tests show that the 6 mass% Mn-or Fe-added CCWN alloys exhibit the same corrosion current density as the ASTM F90 alloy. Mn-added Co-Cr-W-Ni alloys are suitable for use in balloon-expandable stents.
Visible-light-induced antibacterial activity of carbon and nitrogen co-doped rutile TiO<inf>2</inf> films

Ryusuke Koizumi, Kyosuke Ueda, Koyu Ito, Kouetsu Ogasawara, Hiroyasu Kanetaka, Takayuki Mokudai, Takayuki Narushima

Thin Solid Films　780　2023/09/01

DOI： 10.1016/j.tsf.2023.139944 　

ISSN： 0040-6090
Electronic structure analysis of light-element-doped anatase TiO2 using all-electron GW approach Peer-reviewed

Takashi Ishikawa, Ryoji Sahara, Kaoru Ohno, Kyosuke Ueda, Takayuki Narushima

Computational Materials Science　220　112059　2023/03

DOI： 10.1016/j.commatsci.2023.112059 　
Effect of niobium and oxygen contents on microstructure and mechanical properties of α+β-type Ti-(5–25)Nb-(0.5–1)O (mass%) alloys for biomedical applications Peer-reviewed

K. Ueda, M. Omiya, K. Kato, H. Kanetaka, T. Narushima

Mater. Trans.　64　(1)　138-146　2023/01

DOI： 10.2320/matertrans.MT-MLA2022020 　
Antibacterial properties of TiO2 layers formed by Au-sputtering and thermal oxidation of titanium under visible light Peer-reviewed

T. Ueda, R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, H. Kanetaka, T. Narushima

Mater. Trans.　63　(12)　155-164　2023/01

DOI： 10.2320/matertrans.MT-MLA2022006 　

ISSN： 1345-9678
Improvement of mechanical properties of Co–Cr–W–Ni alloy tube suitable for balloon-expandable stent applications through heat treatment Peer-reviewed

Shunsei Takeda, Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Materials Science and Engineering: A　862　144505-144505　2023/01
Publisher: Elsevier BV
DOI： 10.1016/j.msea.2022.144505 　

ISSN： 0921-5093
TOUGH YET FLEXIBLE SUPERELASTIC ALLOYS MEET BIOMEDICAL NEEDS

Xiao Xu, Takumi Odaira, Sheng Xu, Kenji Hirata, Toshihiro Omori, Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima, Makoto Nagasako, Ryosuke Kainuma, Stefanus Harjo, Takuro Kawasaki, Lucie Bodnarova, Petr Sedlak, Hanus Seiner

ADVANCED MATERIALS & PROCESSES　180　(7)　35-37　2022/10

ISSN： 0882-7958

eISSN： 2161-9425
Analysis of the oxidation and nitridation of Ti-17 (Ti-5Al-2Sn-2Zr-4Mo-4Cr) alloys with added Si in atmospheric heating Peer-reviewed

Narushima, S. Suzuki, K. Ueda, S.K. Bhattacharya, R. Sahara

ISIJ Int.　62　(7)　1512-1521　2022/07

DOI： 10.2355/isijinternational.ISIJINT-2022-053 　
Flexible and Tough Superelastic Co–Cr Alloys for Biomedical Applications International-journal

Takumi Odaira, Sheng Xu, Kenji Hirata, Xiao Xu, Toshihiro Omori, Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima, Makoto Nagasako, Stefanus Harjo, Takuro Kawasaki, Lucie Bodnárová, Petr Sedlák, Hanuš Seiner, Ryosuke Kainuma

Advanced Materials　34　(27)　2202305-2202305　2022/06/03
Publisher: Wiley
DOI： 10.1002/adma.202202305 　

ISSN： 0935-9648

eISSN： 1521-4095

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The demand for biomaterials has been increasing along with the increase in the population of elderly people worldwide. The mechanical properties and high wear resistance of metallic biomaterials make them well-suited for use as substitutes or as support for damaged hard tissues. However, unless these biomaterials also have a low Young's modulus similar to that of human bones, bone atrophy inevitably occurs. Because a low Young's modulus is typically associated with poor wear resistance, it is difficult to realize a low Young's modulus and high wear resistance simultaneously. Also, the superelastic property of shape-memory alloys makes them suitable for biomedical applications, like vascular stents and guide wires. However, due to the low recoverable strain of conventional biocompatible shape-memory alloys, the demand for a new alloy system is high. The novel body-centered-cubic cobalt-chromium-based alloys in this work provide a solution to both of these problems. The Young's modulus of <001>-oriented single-crystal cobalt-chromium-based alloys is 10-30 GPa, which is similar to that of human bone, and they also demonstrate high wear and corrosion resistance. They also exhibit superelasticity with a huge recoverable strain up to 17.0%. For these reasons, the novel cobalt-chromium-based alloys can be promising candidates for biomedical applications.
Electronegativity Difference as a Descriptor for the Oxidation-Inhibiting Effect of the Alloying Element during the Early Stages of Titanium Oxidation

Kanika Kohli, Somesh Kr. Bhattacharya, Kyosuke Ueda, Takayuki Narushima, Ryoji Sahara, Prasenjit Ghosh

Langmuir　38　(4)　1448-1457　2022/02/01
Publisher: American Chemical Society (ACS)
DOI： 10.1021/acs.langmuir.1c02633 　

ISSN： 0743-7463

eISSN： 1520-5827
Development of Low-Yield Stress Co–Cr–W–Ni Alloy by Adding 6 Mass Pct Mn for Balloon-Expandable Stents

Soh Yanagihara, Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Metallurgical and Materials Transactions A　52　(9)　4137-4145　2021/09
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11661-021-06374-7 　

ISSN： 1073-5623

eISSN： 1543-1940

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<title>Abstract</title>This is the first report presenting the development of a Co–Cr–W–Ni–Mn alloy by adding 6 mass pct Mn to ASTM F90 Co–20Cr–15W–10Ni (CCWN, mass pct) alloy for use as balloon-expandable stents with an excellent balance of mechanical properties and corrosion resistance. The effects of Mn addition on the microstructures as well as the mechanical and corrosion properties were investigated after hot forging, solution treatment, swaging, and static recrystallization. The Mn-added alloy with a grain size of ~ 20 <italic>µ</italic>m (recrystallization condition: 1523 K, 150 seconds) exhibited an ultimate tensile strength of 1131 MPa, 0.2 pct proof stress of 535 MPa, and plastic elongation of 66 pct. Additionally, it exhibited higher ductility and lower yield stress while maintaining high strength compared to the ASTM F90 CCWN alloy. The formation of intersecting stacking faults was suppressed by increasing the stacking fault energy (SFE) with Mn addition, resulting in a lower yield stress. The low-yield stress is effective in suppressing stent recoil. In addition, strain-induced martensitic transformation during plastic deformation was suppressed by increasing the SFE, thereby improving the ductility. The Mn-added alloys also exhibited good corrosion resistance, similar to the ASTM F90 CCWN alloy. Mn-added Co–Cr–W–Ni alloys are suitable for use as balloon-expandable stents.
Preparation of Ultra High Purity Magnesium Sheet by Vacuum Distillation, Extrusion and Forging

Keito Mizuhara, Makoto Inoue, Tetsuo Aida, Kyosuke Ueda, Takahiro Mineta, Hiromi Miura

Transactions on GIGAKU　7　2021/08

DOI： 10.34468/gigaku.8.1_08003-1 　
Effect of Precursor Deficiency Induced Ca/P Ratio on Antibacterial and Osteoblast Adhesion Properties of Ag-Incorporated Hydroxyapatite: Reducing Ag Toxicity

Ozkan Gokcekaya, Celaletdin Ergun, Thomas J. Webster, Abdurrahman Bahadir, Kyosuke Ueda, Takayuki Narushima, Takayoshi Nakano

Materials　14　(12)　3158-3158　2021/06/08
Publisher: MDPI AG
DOI： 10.3390/ma14123158 　

eISSN： 1996-1944
Improvement of Mechanical Properties by Microstructural Evolution of Biomedical Co–Cr–W–Ni Alloys with the Addition of Mn and Si

Kosuke Ueki, Soh Yanagihara, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

MATERIALS TRANSACTIONS　62　(2)　229-238　2021/02/01
Publisher: Japan Institute of Metals
DOI： 10.2320/matertrans.mt-m2020300 　

ISSN： 1345-9678

eISSN： 1347-5320
Improvement of Strength and Ductility by Combining Static Recrystallization and Unique Heat Treatment in Co-20Cr-15W-10Ni Alloy for Stent Application

Kosuke Ueki, Soh Yanagihara, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Materials Science Forum　1016　1503-1509　2021/01/05
Publisher: Trans Tech Publications, Ltd.
DOI： 10.4028/www.scientific.net/msf.1016.1503 　

ISSN： 0255-5476

eISSN： 1662-9752
Crystallographic orientation control of pure chromium via laser powder bed fusion and improved high temperature oxidation resistance Peer-reviewed

Ozkan Gokcekaya, Naohiro Hayashi, Takuya Ishimoto, Kyosuke Ueda, Takayuki Narushima, Takayoshi Nakano

Additive Manufacturing　36　101624-101624　2020/12
Publisher: Elsevier BV
DOI： 10.1016/j.addma.2020.101624 　

ISSN： 2214-8604

eISSN： 2214-8604
Formation of carbon-added anatase-rich TiO2 layers on titanium and their antibacterial properties in visible light International-journal Peer-reviewed

Takatoshi Ueda, Naoki Sato, Ryusuke Koizumi, Kyosuke Ueda, Koyu Ito, Kouetsu Ogasawara, Takayuki Narushima

Dental Materials　37　(2)　e37-e46　2020/11
Publisher: Elsevier BV
DOI： 10.1016/j.dental.2020.10.009 　

ISSN： 0109-5641

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OBJECTIVE: To avoid risk of infections associated with dental implants, thermal oxidation processes for practical dental Ti alloys were studied for both high bonding strength and antibacterial properties in visible light. METHODS: Two-step thermal oxidation, comprising carburization (first step of treatment: in Ar-1%CO gas) and subsequent oxidation (second step of treatment: in air), was conducted on commercially pure (CP) Ti, Ti-6Al-4V (Ti64), and Ti-6Al-7Nb (Ti67) alloys to form TiO2 layers. Their bonding strengths and antibacterial properties against Escherichia coli (E. coli) in visible light (λ ≥ 400 nm) were evaluated. RESULTS: TiO2 layers formed on each metal were composed of anatase and/or rutile. Anatase fraction and carbon concentration in the layers decreased with increasing temperature in the second step of treatment. Antibacterial properties of the TiO2 layers were dependent on the temperature in the second step of treatment. An approximate antibacterial activity value of 2 (killing ∼99% bacteria) was obtained when the temperatures in the second step of treatment were 673 and 773 K for CP Ti, 773 K for Ti64, and 773 and 873 K for Ti67. It was found that the TiO2 layer must contain carbon and be anatase-rich to exhibit excellent antibacterial properties. Bonding strength between the substrate and TiO2 layers formed at 773 K in the second step of treatment exceeded 80 MPa and was independent of substrate type. SIGNIFICANCE: TiO2 layers, possessing both high bonding strength and excellent antibacterial properties, were successfully formed on practical dental Ti alloys via two-step thermal oxidation.
Fabrication and bioresorbability of Ag- and Ta-containing amorphous calcium phosphate films formed on titanium substrates by RF magnetron sputtering Peer-reviewed

Jun Wu, Kyosuke Ueda, Takayuki Narushima

MATEC Web of Conferences　321　05007-05007　2020/10
Publisher: EDP Sciences
DOI： 10.1051/matecconf/202032105007 　

eISSN： 2261-236X

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Silver (Ag)- and tantalum (Ta)-containing amorphous calcium phosphate (ACP) coating films were fabricated on titanium substrates by radiofrequency magnetron sputtering for biomedical applications. The sputtering targets were hot-pressed into 10 mol% Ag-containing ß-tricalcium phosphate sintered compacts with and without 8 mol% Ta. The fabricated ACP coating films were dense and smooth, with all elements distributed homogeneously along the depth direction. In addition, Ag existed as ions in the ACP regardless of the presence of Ta. The resorbability of the Ag-containing ACP coating films in simulated body fluids was suppressed by the addition of Ta. The concentration of detected Ag ions was higher in diluted nutrient broth solution than in Tris-HCl solution.
Development of α+β-type biomedical Ti–Nb alloys with high oxygen content Peer-reviewed

K. Ueda, M. Omiya, Y. Hirose, T. Narushima

MATEC Web of Conferences　321　05003-05003　2020/10
Publisher: EDP Sciences
DOI： 10.1051/matecconf/202032105003 　

eISSN： 2261-236X

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Ti-(5–20)Nb-(0.5–1)O alloys (mass%) were investigated for developing low-cost biomedical α+β-type Ti alloy. Ti-(5, 10, 15, 20)Nb-(0.5, 0.75, 1)O alloys (mass%) were arc-melted and forged into bars. The forged alloy bars were heat-treated at 873 to 1373 K for 3.6 ks in an Ar atmosphere and quenched in iced water. β transus (<italic>T</italic>_β) of the Ti-Nb-O alloys decreased with increasing Nb content. An increase in the oxygen content led to an increase in <italic>T</italic>_β. After quenching, the formation of α′ martensite was observed in Ti-5Nb-<italic>y</italic>O alloys. An increase in the Nb content to 10 mass% led to the formation of α′ and α″ martensites. A further increase in the Nb content to 15 and 20mass% resulted in the formation of more α″ martensites. The boundary temperature for the formation of α′ and α″ martensite in the Ti-10Nb-<italic>y</italic>O alloys increased with increasing oxygen content, because oxygen enhances the Nb distribution to the β phase. The ultimate tensile strength of the Ti-<italic>x</italic>Nb-0.75O alloys heattreated to obtain the α-phase fraction (<italic>f</italic>_α) of 0.5 was over 1000 MPa, except for the Ti-15Nb-0.75O alloy. The total elongation decreased with increasing Nb content. The Ti-5Nb-0.75O alloy exhibited excellent strength-ductility balance as a low-cost α+β-type biomedical Ti alloy.
Using HAADF-STEM for atomic-scale evaluation of incorporation of antibacterial Ag atoms in a β-tricalcium phosphate structure. International-journal Peer-reviewed

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima, Takayoshi Nakano

Nanoscale　12　(31)　16596-16604　2020/08/21

DOI： 10.1039/d0nr04208k 　

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Structural evaluation of ionic additions in calcium phosphates that enhance their performance is a long-lasting area of research in the field of biomedical materials. Ionic incorporation in β-tricalcium phosphate (β-TCP) structures is indispensable for obtaining desirable properties for specific functions and applications. Owing to its complex structure and beam-sensitive nature, determining the extent of ion incorporation and its corresponding location in the β-TCP structure is challenging. Further, very few experimental studies have been able to estimate the location of Ag atoms incorporated in a β-TCP structure while considering the associated changes in lattice parameters. Although the incorporation alters the lattice parameters, the alteration is not significant enough for estimating the location of the incorporated Ag atoms. Here, Ag incorporation in a β-TCP structure was evaluated on atomic scale using scanning transmission electron microscopy (STEM). To the best of our knowledge, this is the first report to unambiguously determine the location of the incorporated Ag atoms in the β-TCP structure by comparing z-contrast profiles of the Ag and Ca atoms by combining the state-of-art STEM observations and STEM image simulations. The Ag incorporation in the Ca(4) sites of β-TCP, as estimated by the Rietveld refinement, was in good agreement with the high-angle annular dark-field STEM observations and the simulations of the location of Ag atoms for [001] and [010] zone axes.
Fabrication of Ag and Ta co-doped amorphous calcium phosphate coating films by radiofrequency magnetron sputtering and their antibacterial activity Peer-reviewed

Jun Wu, Kyosuke Ueda, Takayuki Narushima

Materials Science and Engineering: C　109　110599-110599　2020/04
Publisher: Elsevier BV
DOI： 10.1016/j.msec.2019.110599 　

ISSN： 0928-4931
水素プラズマを利用したチタン融体からの酸素除去 Peer-reviewed

成島尚之, 上田恭介, 阿部来紀

軽金属　70　316-317　2020
Si添加Ti–6Al–4V合金の高温酸化に関する実験的・計算材料学的研究

成島尚之, 上田恭介, 佐原亮二, S.K. Bhattacharya

チタン　68　328-335　2020
Precipitation during γ-ε phase transformation in biomedical Co-Cr-Mo alloys fabricated by electron beam melting Peer-reviewed

K. Ueki, M. Kasamatsu, K. Ueda, Y. Koizumi, D. Wei, A. Chiba, T. Narushima

Metals　2019/12
Overcoming the strength-ductility trade-off by the combination of static recrystallization and low-temperature heat-treatment in Co-Cr-W-Ni alloy for stent application Peer-reviewed

Ueki Kosuke, Yanagihara Soh, Ueda Kyosuke, Nakai Masaaki, Nakano Takayoshi, Narushima Takayuki

MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING　766　2019/10/24

DOI： 10.1016/j.msea.2019.138400 　

ISSN： 0921-5093

eISSN： 1873-4936
Effect of Nonmetallic Inclusions on Fatigue Properties of Superelastic Ti-Ni Fine Wire Peer-reviewed

Yamashita Fumiyoshi, Ide Yasunori, Kato Suguru, Ueda Kyosuke, Narushima Takayuki, Kise Sumio, Ishikawa Kouji, Nishida Minoru

METALS　9　(9)　2019/09

DOI： 10.3390/met9090999 　

eISSN： 2075-4701
Deoxidation of Ti Melt by Newly Developed Two-Step Plasma Arc Melting Process Using Hydrogen Peer-reviewed

Watanabe, M., Sato, F., Abe, R., Ueda, K., Matsuwaka, D., Kudo, F., Narushima, T.

Metallurgical and Materials Transactions B: Process Metallurgy and Materials Processing Science　50　(4)　1553-1558　2019/08

DOI： 10.1007/s11663-019-01608-x 　

ISSN： 1073-5615
COX-2 induces T cell accumulation and IFN-γ production during the development of chromium allergy. Peer-reviewed

Sitalaksmi RM, Ito K, Ogasawara K, Suto Y, Itabashi M, Ueda K, Hirasawa N, Narushima T, Hendrijantini N, Kresnoadi U, Sasaki K

Autoimmunity　52　(5-6)　228-234　2019/08

DOI： 10.1080/08916934.2019.1662404 　

ISSN： 0891-6934

eISSN： 1607-842X
Visible-light-responsive antibacterial activity of Au-incorporated TiO2 layers formed on Ti-(0-10)at%Au alloys by air oxidation. International-journal Peer-reviewed

Takatoshi Ueda, Kyosuke Ueda, Koyu Ito, Kouetsu Ogasawara, Hiroyasu Kanetaka, Takayuki Mokudai, Yoshimi Niwano, Takayuki Narushima

Journal of biomedical materials research. Part A　107　(5)　991-1000　2019/05

DOI： 10.1002/jbm.a.36624 　

ISSN： 1549-3296
Experimental and theoretical study of the effect of Si on the oxidative behavior of Ti-6Al-4V alloys Peer-reviewed

Maeda Kodai, Suzuki Satoshi, Ueda Kyosuke, Kitashima Tomonori, Bhattacharya Somesh Kr, Sahara Ryoji, Narushima Takayuki

JOURNAL OF ALLOYS AND COMPOUNDS　776　519-528　2019/03/05

DOI： 10.1016/j.jallcom.2018.10.291 　

ISSN： 0925-8388
Antibacterial activity of Ag nanoparticle-containing hydroxyapatite powders in simulated body fluids with Cl ions Peer-reviewed

Gokcekaya, O., Ueda, K., Ogasawara, K., Narushima, T.

Materials Chemistry and Physics　223　473-478　2019/02/01

DOI： 10.1016/j.matchemphys.2018.11.015 　

ISSN： 0254-0584
Synchronous improvement in strength and ductility of biomedical Co-Cr-Mo alloys by unique low-temperature heat treatment Peer-reviewed

Ueki Kosuke, Abe Mai, Ueda Kyosuke, Nakai Masaaki, Nakano Takayoshi, Narushima Takayuki

MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING　739　53-61　2019/01/02

DOI： 10.1016/j.msea.2018.10.016 　

ISSN： 0921-5093

eISSN： 1873-4936
Formation of Photocatalytically Active TiO2 Layers on Ti-Nb Alloys by Two-Step Thermal Oxidation Peer-reviewed

Sado Shota, Ueda Takatoshi, Tokuda Yosuke, Sato Naoki, Ueda Kyosuke, Narushima Takayuki

MATERIALS TRANSACTIONS　60　(9)　1814-1820　2019

DOI： 10.2320/matertrans.ME201901 　

ISSN： 1345-9678
Mechanisms of oxidation of pure and Si-segregated α-Ti surfaces Peer-reviewed

Bhattacharya, S.K., Sahara, R., Suzuki, S., Ueda, K., Narushima, T.

Applied Surface Science　463　686-692　2019/01/01

DOI： 10.1016/j.apsusc.2018.08.253 　

ISSN： 0169-4332
Heterogeneous microstructures and corrosion resistance of biomedical Co-Cr-Mo alloy fabricated by electron beam melting (EBM) Peer-reviewed

Daixiu Wei, Yuichiro Koizumi, Akihiko Chiba, Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima, Yusuke Tsutsumi, Takao Hanawa

Additive Manufacturing　24　103-114　2018/12

DOI： 10.1016/j.addma.2018.09.006 　

ISSN： 2214-8604

eISSN： 2214-8604
Microstructural Changes During Plastic Deformation and Corrosion Properties of Biomedical Co-20Cr-15W-10Ni Alloy Heat-Treated at 873 K Peer-reviewed

Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science　49　(6)　2393-2404　2018/06/01

DOI： 10.1007/s11661-018-4597-0 　

ISSN： 1073-5623
Microstructural changes during plastic deformation and corrosion properties of biomedical Co-Cr-W-Ni alloy heat-treated at 873 K Peer-reviewed

Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima

Metallurgical and Materials Transactions A　2018/04
Corrosion resistance and mechanical properties of titanium nitride plating on orthodontic wires. Peer-reviewed

Haruki Sugisawa, Hideki Kitaura, Kyosuke Ueda, Keisuke Kimura, Masahiko Ishida, Yumiko Ochi, Akiko Kishikawa, Saika Ogawa, Teruko Takano-Yamamoto

Dental materials journal　37　(2)　286-292　2018/03/30

DOI： 10.4012/dmj.2016-348 　

ISSN： 0287-4547
Effect of Si on the oxidation reaction of α-Ti(0 0 0 1) surface: ab initio molecular dynamics study Peer-reviewed

Somesh Kr. Bhattacharya, Ryoji Sahara, Kyosuke Ueda, Takayuki Narushima

Science and Technology of Advanced Materials　18　(1)　998-1004　2017/12/31

DOI： 10.1080/14686996.2017.1403273 　

ISSN： 1878-5514 1468-6996
First principles study of oxidation of Si-segregated alpha-Ti(0001) surfaces Peer-reviewed

Somesh Kr. Bhattacharya, Ryoji Sahara, Tomonori Kitashima, Kyosuke Ueda, Takayuki Narushima

JAPANESE JOURNAL OF APPLIED PHYSICS　56　(12)　125701　2017/12

DOI： 10.7567/JJAP.56.125701 　

ISSN： 0021-4922

eISSN： 1347-4065
TiNコーティングを施した歯科矯正用ワイヤーの摩擦力の検討

杉澤晴紀, 北浦英樹, 上田恭介, 木村桂介, 石田匡彦, 山本照子

日本矯正歯科学会大会プログラム・抄録集　76回　208-208　2017/10
Publisher: (公社)日本矯正歯科学会
In vitro performance of Ag-incorporated hydroxyapatite and its adhesive porous coatings deposited by electrostatic spraying Peer-reviewed

Ozkan Gokcekaya, Thomas J. Webster, Kyosuke Ueda, Takayuki Narushima, Celaletdin Ergun

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　77　556-564　2017/08

DOI： 10.1016/j.msec.2017.03.233 　

ISSN： 0928-4931

eISSN： 1873-0191
In vitro evaluation of Ag-containing calcium phosphates: Effectiveness of Ag-incorporated beta-tricalcium phosphate Peer-reviewed

Ozkan Gokcekaya, Kyosuke Ueda, Kouetsu Ogasawara, Hiroyasu Kanetaka, Takayuki Narushima

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　75　926-933　2017/06

DOI： 10.1016/j.msec.2017.02.059 　

ISSN： 0928-4931

eISSN： 1873-0191
TRAV7-2*02 Expressing CD8⁺ T Cells Are Responsible for Palladium Allergy. International-journal Peer-reviewed

Yuri Takeda, Yoshiko Suto, Koyu Ito, Wataru Hashimoto, Tadashi Nishiya, Kyosuke Ueda, Takayuki Narushima, Tetsu Takahashi, Kouetsu Ogasawara

International journal of molecular sciences　18　(6)　1162 (12 pages)　2017/05/31

DOI： 10.3390/ijms18061162 　

ISSN： 1422-0067
Ceramic coating of Ti and its alloys using dry processes for biomedical applications Peer-reviewed

T. Ueda, N. Kondo, S. Sado, O. Gokcekaya, K. Ueda, K. Ogasawara, T. Narushima

Interface Oral Health Science 2016, Innovative Research on Biosis-Abiosis Intelligent Interface　Chapter 2　22-34　2017

DOI： 10.1007/978-981-10-1560-1_2 　
Development and performance of low cost beta-type Ti-based alloys for biomedical applications using Mn additions Peer-reviewed

P. F. Santos, M. Niinomi, H. Liu, M. Nakai, K. Cho, T. Narushima, K. Ueda, N. Ohtsu, M. Hirano

Interface Oral Health Science 2016, Innovative Research on Biosis-Abiosis Intelligent Interface　Chapter 19　229-246　2017

DOI： 10.1007/978-981-10-1560-1_19 　
Effects of Mo Addition on the Mechanical Properties and Microstructures of Ti-Mn Alloys Fabricated by Metal Injection Molding for Biomedical Applications Peer-reviewed

Pedro Fernandes Santos, Mitsuo Niinomi, Ken Cho, Huihong Liu, Masaaki Nakai, Takayuki Narushima, Kyosuke Ueda, Yoshinori Itoh

MATERIALS TRANSACTIONS　58　(2)　271-279　2017

DOI： 10.2320/matertrans.M2016286 　

ISSN： 1345-9678

eISSN： 1347-5320
In vitro properties of Ag-containing calcium phosphates Peer-reviewed

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima, Kouetsu Ogasawara, Hiroyasu Kanetaka

Ceramic Engineering and Science Proceedings　37　(4)　87-93　2017
Publisher: American Ceramic Society
DOI： 10.1002/9781119321682.ch10 　

ISSN： 0196-6219
Preparation of orthophosphate glasses in the MgO-CaO-SiO2-Nb2O5-P2O5 system Peer-reviewed

Sungho Lee, Kyosuke Ueda, Takayuki Narushima, Takayoshi Nakano, Toshihiro Kasuga

BIO-MEDICAL MATERIALS AND ENGINEERING　28　(1)　23-30　2017

DOI： 10.3233/BME-171652 　

ISSN： 0959-2989

eISSN： 1878-3619
Removal of Oxygen in Ti-Si Melts by Arc-Melting Peer-reviewed

Masahito Watanabe, Fumiya Sato, Kyosuke Ueda, Daisuke Matsuwaka, Takayuki Narushima

MATERIALS TRANSACTIONS　58　(4)　613-618　2017

DOI： 10.2320/matertrans.M2017003 　

ISSN： 1345-9678

eISSN： 1347-5320
Microstructure and Mechanical Properties of an alpha plus beta Type Ti-4V-0.6O Alloy Peer-reviewed

Masahito Omiya, Kyosuke Ueda, Takayuki Narushima

MATERIALS TRANSACTIONS　58　(9)　2017

DOI： 10.2320/matertrans.L-M2017825 　

ISSN： 1345-9678

eISSN： 1347-5320
TiO2 layers on Ti-Au alloy formed by two-step thermal oxidation and their photocatalytic activity in visible-light Peer-reviewed

Takatoshi Ueda, Shota Sado, Kyosuke Ueda, Takayuki Narushima

MATERIALS LETTERS　185　290-294　2016/12

DOI： 10.1016/j.matlet.2016.08.066 　

ISSN： 0167-577X

eISSN： 1873-4979
Formation of porous layer with low Ni content on NiTi substrate by dealloying in metallic melts Peer-reviewed

Kyosuke Ueda, Ryuma Hashimoto, Masahiro Hirohashi, Takeshi Wada, Hidemi Kato, Takayuki Narushima

Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy　63　(8)　766-770　2016/07/01
Publisher: Journal of the Japan Society of Powder and Powder Metallurgy
DOI： 10.2497/jjspm.63.766 　

ISSN： 0532-8799
The antihistamine olopatadine regulates T cell activation in palladium allergy Peer-reviewed

Naohiko Iguchi, Yuri Takeda, Naoki Sato, Kenichirou Ukichi, Akira Katakura, Kyosuke Ueda, Takayuki Narushima, Shigehito Higuchi, Kouetsu Ogasawara

INTERNATIONAL IMMUNOPHARMACOLOGY　35　70-76　2016/06

DOI： 10.1016/j.intimp.2016.03.021 　

ISSN： 1567-5769

eISSN： 1878-1705
Microstructure and Mechanical Properties of Heat-Treated Co-20Cr-15W-10Ni Alloy for Biomedical Application Peer-reviewed

Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　47A　(6)　2773-2782　2016/06

DOI： 10.1007/s11661-016-3488-5 　

ISSN： 1073-5623

eISSN： 1543-1940
Formation and evaluation of thermally-oxidized titania layers on commercially pure Ti Peer-reviewed

T. Narushima, N. Umetsu, T. Ueda, S. Sado, K. Ueda

Proceedings of Ti-2015: The 13th World Conference on Titanium　1717-1721　2016/05/06

DOI： 10.1002/9781119296126.ch288 　
Preparation of Antibacterial ZnO-CaO-P2O5-Nb2O5 Invert Glasses Peer-reviewed

Sungho Lee, Hirotaka Uehara, Anthony L, B. Maçon, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

Materials Transactions　30　30-34　2016/04
中堅研究者から見た金属系バイオマテリアルの現状とこれから Peer-reviewed

上田恭介

バイオマテリアル　34　(4)　268-271　2016/04
Structures and dissolution behaviors of MgO-CaO-P2O5-Nb2O5 glasses Peer-reviewed

Sungho Lee, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

JOURNAL OF NON-CRYSTALLINE SOLIDS　438　18-25　2016/04

DOI： 10.1016/j.jnoncrysol.2016.02.006 　

ISSN： 0022-3093

eISSN： 1873-4812
The role of niobium ions in calcium phosphate invert glasses for bone regeneration Peer-reviewed

A. Obata, H. Maeda, K. Ueda, T. Narushima, T. Kasuga

Phos. Res. Bull.　30　30-34　2016/03/02
Publisher: Japanese Association of Inorganic Phosphorus Chemistry
DOI： 10.3363/prb.30.30 　

ISSN： 0918-4783

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Abstract: Phosphate invert glasses (PIGs) containing niobium were prepared by a conventional melt-quenching method and the structures and chemical durability of the glasses and osteoblast-like cell responses to them were examined. Raman and solid state ³¹ P NMR spectra of the glasses demonstrated that two types of niobate groups, NbO₄ and NbO₆ units, were contained in the glasses and prepared to combine to pyrophosphate structure than orthophosphate one. The chemical durability in Tris-HCl solution was increased with the increase in the niobium content in the glasses, since niobium replaced to phosphorus and contributed to the formation of P-O-Nb and Nb-O-Nb bonds, which are stronger than P-O-P bond. The niobium ions released from the glasses enhanced the differentiation and mineralization of the cells, rather than the initial adhesion and proliferation. The upregulation of these cell functions by the niobium ions possessed doze-dependence; the medium containing 1 x 10^-7 M of the ions exhibited the highest levels of the cell functions.
Preface to Special Issue on Current Issues and Future Perspectives of Design and Manufacturing Process of Biomedical Metallic Devices Peer-reviewed

Y. Koizumi, K. Ueda, Y. Tsutsumi, T. Ishimoto, N. Ohtsu, Y. Tanaka

Materia Japan　55　(4)　131-132　2016/02/29
Publisher: The Japan Institute of Metals and Materials
DOI： 10.2320/materia.55.131 　

ISSN： 1340-2625
Structure and physicochemical properties of CaO-P2O5-Nb2O5-Na2O glasses Peer-reviewed

Hirotaka Maeda, Sungho Lee, Tomohiro Miyajima, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

JOURNAL OF NON-CRYSTALLINE SOLIDS　432　60-64　2016/01

DOI： 10.1016/j.jnoncrysol.2015.06.003 　

ISSN： 0022-3093

eISSN： 1873-4812
Microstructure and Mechanical Property of alpha plus beta Type Ti-(0 similar to 10) mass%V-(0.5 similar to 1) mass%O Alloys Peer-reviewed

Kyosuke Ueda, Tatsuya Kobayashi, Takayuki Narushima

JOURNAL OF THE JAPAN INSTITUTE OF METALS　80　(1)　60-65　2016

DOI： 10.2320/jinstmet.JB201503 　

ISSN： 0021-4876

eISSN： 1880-6880
In vitro properties of Ag-containing calcium phosphate Peer-reviewed

O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara, H. Kanetaka

Proceedings of 40th International Conference and Expo on Advanced Ceramics and Composites　2016
Optimization of Microstructure and Mechanical Properties of Co-Cr-Mo Alloys by High-Pressure Torsion and Subsequent Short Annealing Peer-reviewed

Murat Isik, Mitsuo Niinomi, Huihong Liu, Ken Cho, Masaaki Nakai, Zenji Horita, Takayuki Narushima, Kyosuke Ueda

MATERIALS TRANSACTIONS　57　(11)　1887-1896　2016

DOI： 10.2320/matertrans.M2016112 　

ISSN： 1345-9678

eISSN： 1347-5320
Preparation of Antibacterial ZnO-CaO-P2O5-Nb2O5 Invert Glasses Peer-reviewed

Sungho Lee, Hirotaka Uehara, Anthony L. B. Macon, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

MATERIALS TRANSACTIONS　57　(12)　2072-2076　2016

DOI： 10.2320/matertrans.MI201503 　

ISSN： 1345-9678

eISSN： 1347-5320
Effects of Precipitates and Albumin in Simulated Body Fluids on Pin-on-Disk Wear Behavior of Biomedical Co-Cr-Mo Alloys Peer-reviewed

Kyosuke Ueda, Motoka Kasamatsu, Masanori Tanno, Kosuke Ueki, Jean Geringer, Takayuki Narushima

MATERIALS TRANSACTIONS　57　(12)　2054-2059　2016

DOI： 10.2320/matertrans.MI201518 　

ISSN： 1345-9678

eISSN： 1347-5320
Changes in Microstructure of Biomedical Co-Cr-Mo Alloys during Aging at 973 to 1373 K Peer-reviewed

Kosuke Ueki, Yuto Kurihara, Shingo Mineta, Alfirano, Kyosuke Ueda, Shigenobu Namba, Takashi Yoneda, Takayuki Narushima

MATERIALS TRANSACTIONS　57　(12)　2048-2053　2016

DOI： 10.2320/matertrans.MI201507 　

ISSN： 1345-9678

eISSN： 1347-5320
Rotating-bending Fatigue Properties of NiTi Wires for Biomedical Applications Peer-reviewed

K. Hara, K. Ueda, T. Narushima, F. Yamashita, K. Ishikawa

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　20-28　2015/12
Formation of TiO2 layers on commercially pure Ti and Ti-Mo and Ti-Nb alloys by two-step thermal oxidation and their photocatalytic activity Peer-reviewed

Shota Sado, Takatoshi Ueda, Kyosuke Ueda, Takayuki Narushima

APPLIED SURFACE SCIENCE　357　2198-2205　2015/12

DOI： 10.1016/j.apsusc.2015.09.211 　

ISSN： 0169-4332

eISSN： 1873-5584
Effect of light elements on fatigue properties of NiTi wires for designing biomedical stents Peer-reviewed

K. Hara, K. Ueda, T. Narushima, F. Yamashita, K. Ishikawa

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　20-28　2015/12
Microstructure, tensile properties and corrosive properties of ASTM F90 Co-20Cr-15W-10Ni Alloys Peer-reviewed

K. Ueki, K. Ueda, T. Narushima

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　50-58　2015/12
In vitro evaluation of Ag-containing calcium phosphates Peer-reviewed

O. Gokcekaya, K. Ueda, T. Narushima, K. Ogasawara

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　95-103　2015/12
Behavior of oxygen in arc-melted Ti-Si alloys Peer-reviewed

M. Watanabe, K. Ueda, D. Matsuwaka, T. Narushima

Proceedings of the 24th International Symposium on Processing and Fabrication of Advanced Materials, PFAM XXIV　513-520　2015/12
Zrイオンプレーティング処理Ni-Tiワイヤーのフッ素含有環境下における耐食性評価

布目祥子, 金高弘恭, 上田恭介, 成島尚之, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　74回　219-219　2015/11
Publisher: (公社)日本矯正歯科学会
TiNコーティングを施した歯科矯正用ワイヤーの耐食性および機械的特性の検討

杉澤晴紀, 北浦英樹, 上田恭介, 木村桂介, 石田匡彦, 越智由美子, 岸川明子, 山本照子

日本矯正歯科学会大会プログラム・抄録集　74回　218-218　2015/11
Publisher: (公社)日本矯正歯科学会
Visible light activities of TiO₂ layers formed on Ti-Ag and Ti-Au alloys by thermal oxidation Peer-reviewed

T. Ueda, S. Sado, K. Ueda, T. Narushima

Proceedings for International Symposium on Eco Topia Science 2015　2015/11
Structures and dissolution behaviors of CaO-P2O5-TiO2/Nb2O5 (Ca/P >= 1) invert glasses Peer-reviewed

Sungho Lee, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

JOURNAL OF NON-CRYSTALLINE SOLIDS　426　35-42　2015/10

DOI： 10.1016/j.jnoncrysol.2015.06.024 　

ISSN： 0022-3093

eISSN： 1873-4812
Structure and dissolution behavior of MgO-P2O5-TiO2/Nb2O5 (Mg/P >= 1) invert glasses Peer-reviewed

Sungho Lee, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　123　(1442)　942-948　2015/10

DOI： 10.2109/jcersj2.123.942 　

ISSN： 1882-0743

eISSN： 1348-6535
Formation of the chi-Phase Precipitate in Co-28Cr-6Mo Alloys with Additional Si and C Peer-reviewed

Kei Sugawara, Alfirano, Shingo Mineta, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　46A　(9)　4342-4350　2015/09

DOI： 10.1007/s11661-015-3008-z 　

ISSN： 1073-5623

eISSN： 1543-1940
Synthesis and characterization of Ag-containing calcium phosphates with various Ca/P ratios Peer-reviewed

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima, Celaletdin Ergun

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　53　111-119　2015/08

DOI： 10.1016/j.msec.2015.04.025 　

ISSN： 0928-4931

eISSN： 1873-0191
Control of bioresorbability of amorphous calcium phosphate coating film with niobium added Peer-reviewed

K. Ueda, T. Takahashi, A. Obata, T. Kasuga, T. Goto, T. Narushima

Proceedings of the Biomaterials International Conference 2015　1026　2015/06
Effect of heat treatment of the microstructure and mechanical properties of biomedical Co-20Cr-15W-10Ni alloy Peer-reviewed

K. Ueki, K. Ueda, T. Narushima

Proceedings of the Biomaterials International Conference 2015　1182　2015/06
Evaluation of photocatalytic activity of the tio2 layer formed on ti by thermal oxidation Peer-reviewed

Takayuki Narushima, Shota Sado, Natsumi Kondo, Kyosuke Ueda

Interface Oral Health Science 2014: Innovative Research on Biosis-Abiosis Intelligent Interface　65-78　2015/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-55192-8_6 　
CONTROL OF Ag RELEASE FROM Ag-CONTAINING CALCIUM PHOSPHATES IN SIMULATED BODY FLUID Peer-reviewed

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima

BIOMATERIALS SCIENCE: PROCESSING, PROPERTIES, AND APPLICATIONS V　254　13-20　2015

ISSN： 1042-1122
Evaluation of Thin Amorphous Calcium Phosphate Coatings on Titanium Dental Implants Deposited Using Magnetron Sputtering Peer-reviewed

Sou Yokota, Naruhiko Nishiwaki, Kyosuke Ueda, Takayuki Narushima, Hiroshi Kawamura, Tetsu Takahashi

IMPLANT DENTISTRY　23　(3)　343-350　2014/06

DOI： 10.1097/ID.0000000000000098 　

ISSN： 1056-6163
チタン中における希土類酸化物の溶解/析出挙動 Peer-reviewed

上田恭介

チタン　62　(4)　269　2014/04
Preface to Special Issue on Present and Future Requirements for Development of Biomedical Materialssues and Future Perspectives of Design and Manufacturing Process of Biomedical Metallic Devices Peer-reviewed

仲井正昭, 小泉雄一郎, 上田正人, 三浦永理, 大津直史, 廣本祥子, 石本卓也, 上田恭介

Materia Japan　53　(4)　133-133　2014/04/01
Publisher: The Japan Institute of Metals and Materials
DOI： 10.2320/materia.53.133 　

ISSN： 1340-2625
NKG2D(+) IFN-gamma(+) CD8(+) T Cells Are Responsible for Palladium Allergy Peer-reviewed

Mitsuko Kawano, Masafumi Nakayama, Yusuke Aoshima, Kyohei Nakamura, Mizuho Ono, Tadashi Nishiya, Syou Nakamura, Yuri Takeda, Akira Dobashi, Akiko Takahashi, Misato Endo, Akiyo Ito, Kyosuke Ueda, Naoki Sato, Shigehito Higuchi, Takeru Kondo, Suguru Hashimoto, Masamichi Watanabe, Makoto Watanabe, Tetsu Takahashi, Keiichi Sasaki, Masanori Nakamura, Takehiko Sasazuki, Takayuki Narushima, Ryuji Suzuki, Kouetsu Ogasawara

PLOS ONE　9　(2)　e86810　2014/02

DOI： 10.1371/journal.pone.0086810 　

ISSN： 1932-6203
Preparation of calcium pyrophosphate glass-ceramics containing Nb2O5 Peer-reviewed

Hirotaka Maeda, Tomohiro Miyajima, Sungho Lee, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　122　(1421)　122-124　2014/01

DOI： 10.2109/jcersj2.122.122 　

ISSN： 1882-0743

eISSN： 1348-6535
Precipitate phases and mechanical properties of heat-treated ASTM F 90 Co-Cr-W-Ni alloy Peer-reviewed

Kosuke Ueki, Kyosuke Ueda, Takayuki Narushima

ADVANCED CERAMICS AND NOVEL PROCESSING　616　258-262　2014

DOI： 10.4028/www.scientific.net/KEM.616.258 　

ISSN： 1013-9826
Photocatalytic evaluation of anatase layer formed on Ti alloys by thermal oxidation Peer-reviewed

S. Sado, K. Ueda, T. Narushima, M. Kawano, K. Ogasawara

Proceedings for International Symposium on Eco Topia Science 2013　1131　2013/11
Ag distribution in calcium phosphates with various Ca/P ratios Peer-reviewed

O. Gokcekaya, K. Ueda, T. Narushima, C. Ergun

Proceedings for International Symposium on Eco Topia Science 2013　1113　2013/11
Preparation of Ag-doped calcium phosphates Peer-reviewed

O. Gokcekaya, K. Ueda, T. Narushima, C. Ergun

Proceedings of the 8th Pacific Rim International Congress on Advanced Materials and Processing　1679-1685　2013/08/05

DOI： 10.1002/9781118792148.ch211 　
Formation of Anatase on Commercially Pure Ti by Two-Step Thermal Oxidation Using N-2-CO Gas Peer-reviewed

Nobuyuki Umetsu, Shota Sado, Kyosuke Ueda, Kazuki Tajima, Takayuki Narushima

MATERIALS TRANSACTIONS　54　(8)　1302-1307　2013/08

DOI： 10.2320/matertrans.ME201315 　

ISSN： 1345-9678

eISSN： 1347-5320
Effect of Ba deoxidation on oxygen content in NiTi alloys and non-metallic inclusions Peer-reviewed

Daisuke Ito, Naruhiko Nishiwaki, Kyosuke Ueda, Takayuki Narushima

JOURNAL OF MATERIALS SCIENCE　48　(1)　359-366　2013/01

DOI： 10.1007/s10853-012-6753-z 　

ISSN： 0022-2461

eISSN： 1573-4803
Phase and Formation/Dissolution of Precipitates in Biomedical Co-Cr-Mo Alloys with Nitrogen Addition Peer-reviewed

Shingo Mineta, Alfirano, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　44A　(1)　494-503　2013/01

DOI： 10.1007/s11661-012-1399-7 　

ISSN： 1073-5623
金属材料のセラミックスコーティング Peer-reviewed

成島尚之, 上田恭介

加工プロセスによる材料機能発現第176委員会第24回研究会資料　62-81　2013
beta-Grain Refinement of alpha+beta-Type Ti-4.5Al-6Nb-2Fe-2Mo Alloy by Using Rare-Earth-Oxide Precipitates Peer-reviewed

Kyosuke Ueda, Shinichiro Nakaoka, Takayuki Narushima

MATERIALS TRANSACTIONS　54　(2)　161-168　2013

DOI： 10.2320/matertrans.MC201207 　

ISSN： 1345-9678

eISSN： 1347-5320
Mass loss and ion elution of biomedical Co-Cr-Mo alloys during pin-on-disk wear tests Peer-reviewed

Kyosuke Ueda, Kaori Nakaie, Shigenobu Namba, Takashi Yoneda, Keita Ishimizu, Takayuki Narushima

Materials Transactions　54　(8)　1281-1287　2013

DOI： 10.2320/matertrans.ME201316 　

ISSN： 1345-9678
RFマグネトロンスパッタリング法による非晶質リン酸カルシウムコーティングの評価

横田聡, 栗原淳, 西脇成彦, 玉手総一郎, 上田恭介, 成島尚之, 川村仁, 高橋哲

Japanese Journal of Maxillo Facial Implants　11　(3)　243-243　2012/11
Publisher: (公社)日本顎顔面インプラント学会
ISSN： 1347-894X
Effects of Niobium Ions Released from Calcium Phosphate Invert Glasses Containing Nb2O5 on Osteoblast-Like Cell Functions Peer-reviewed

Akiko Obata, Yoshiaki Takahashi, Tomohiro Miyajima, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga

ACS APPLIED MATERIALS & INTERFACES　4　(10)　5684-5690　2012/10

DOI： 10.1021/am301614a 　

ISSN： 1944-8244
Precipitates in Biomedical Co-28Cr-6Mo-(0-0.41)C Alloys Heat-Treated at 1473 K to 1623 K (1200 degrees C to 1350 degrees C) Peer-reviewed

Shingo Mineta, Alfirano, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　43A　(9)　3351-3358　2012/09

DOI： 10.1007/s11661-012-1142-4 　

ISSN： 1073-5623
Surface modification of titanium for improvement of the bone compatibility by bioresorbable calcium phosphate coating Invited Peer-reviewed

K. Ueda

Materia Japan　51　(9)　424-427　2012/09
Publisher: The Japan Institute of Metals and Materials
DOI： 10.2320/materia.51.424 　

ISSN： 1340-2625
Precipitates in Biomedical Co-Cr-Mo-C-N-Si-Mn Alloys Peer-reviewed

Alfirano, Shingo Mineta, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　43A　(6)　2125-2132　2012/06

DOI： 10.1007/s11661-011-1009-0 　

ISSN： 1073-5623
Deoxidation of NiTi Alloys Using Metallic Barium and their Microstructures Peer-reviewed

Takayuki Narushima, Daisuke Ito, Kyosuke Ueda

TI-2011: PROCEEDINGS OF THE 12TH WORLD CONFERENCE ON TITANIUM, VOL III　2050-2053　2012
Grain Refinement in alpha plus beta-type Ti-4. 5Al-6Nb-2Fe-2Mo Alloys through Precipitation of TiB or Rare Earth Oxides Peer-reviewed

Yasunori Kimura, Nobuyuki Umetsu, Naomichi Iwata, Shinichiro Nakaoka, Kyosuke Ueda, Takayuki Narushima

TI-2011: PROCEEDINGS OF THE 12TH WORLD CONFERENCE ON TITANIUM, VOL III　2077-2080　2012
Grain Refinement in alpha plus beta-type Ti-4. 5Al-6Nb-2Fe-2Mo Alloys through Precipitation of TiB or Rare Earth Oxides Peer-reviewed

Yasunori Kimura, Nobuyuki Umetsu, Naomichi Iwata, Shinichiro Nakaoka, Kyosuke Ueda, Takayuki Narushima

TI-2011: PROCEEDINGS OF THE 12TH WORLD CONFERENCE ON TITANIUM, VOL III　2077-2080　2012
Two-step Gas Treatment of Commercially Pure Titanium for Anatase Layer Formation Peer-reviewed

Nobuyuki Umetsu, Takuro Okazumi, Kyosuke Ueda, Takayuki Narushima

TI-2011: PROCEEDINGS OF THE 12TH WORLD CONFERENCE ON TITANIUM, VOL III　2106-2110　2012
Calcium phosphate-coated titanium alloy implants prepared by radiofrequency magnetron sputtering: A review Peer-reviewed

Naru Shiraishi, Yuko Suzuki, Naoko Sato, Takahisa Anada, Takashi Goto, Rong Tu, Mitsuo Niinomi, Takayuki Narushima, Kyosuke Ueda, Risa Uzuka, Osamu Suzuki, Keiichi Sasaki

Interface Oral Health Science 2011　352-354　2012/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_102 　
Accelerated bone formation around titanium dental implants with amorphous calcium phosphate coating in rabbits Peer-reviewed

Sou Yokota, Jun Kurihara, Naruhiko Nishiwaki, Soichiro Tamate, Kyosuke Ueda, Takayuki Narushima, Hiroshi Kawamura

Interface Oral Health Science 2011　243-245　2012/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_69 　
π-phase and ᵡ-phase: New precipitates in biomedical Co-Cr-Mo alloys Peer-reviewed

Takayuki Narushima, Shingo Mineta, Alfirano, Kyosuke Ueda

Interface Oral Health Science 2011　72-80　2012/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_12 　
Quantitative analyses of osteogenic-differentiation-related gene expressions in human osteoblast-like cells (SaOS-2) cultured on hydroxyapatite and titanium Peer-reviewed

M. Taira, W. Hatakeyama, H. Kihara, H. Kondo, K. Ueda, T. Narushima

J. Oral Tissue Engin.　10　(1)　34-41　2012
Publisher: Japanese Association of Regenerative Dentistry
DOI： 10.11223/jarde.10.34 　

ISSN： 1348-9623

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The purpose of this study was to examine osteogenic differentiation behaviors at gene expression levels of osteoblast-like cells (SaOS-2) when cultured on polystyrene (PS), hydoroxyapatite (HAP) and titanium (Ti) for 8, 16 and 24 days, using six primer sets such as those for genes (mRNAs) of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), alkaline phosphatase (ALPL), type 1 collagen (COL1A1), osteopontin (SPP1), bone Sialo protein (IBSP) and osteocalcin precursor (BGLAP). With respect to GAPDH control, ALPL and COL1A1; SPP1 and IBSP; and BGLAP were used as initial-stage, middle-to-late-stage, and last-stage osteogenic differentiation phenotype markers, respectively. Quantitative real-time RT-PCR analyses revealed that HAP most differentiated SaOS-2, followed by Ti while PS did least. It was re-confirmed that with respect to PS, HAP was an excellent osteo-conductive material while Ti also exerted moderate osteo-conductive effects on SaOS-2 in the cell culture condition.
Deoxidation of NiTi alloys using metallic barium and their microstructures Peer-reviewed

T. Narushima, D. Ito, K. Ueda

Proc. of the 12th World Conference on Titanium (2011)　2050-2053　2011/12
Precipitates in As-Cast and Heat-Treated ASTM F75 Co-Cr-Mo-C Alloys Containing Si and/or Mn Peer-reviewed

Alfirano, Shingo Mineta, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　42A　(7)　1941-1949　2011/07

DOI： 10.1007/s11661-011-0604-4 　

ISSN： 1073-5623
Anatase formation on titanium by two-step thermal oxidation Peer-reviewed

Takuro Okazumi, Kyosuke Ueda, Kazuki Tajima, Nobuyuki Umetsu, Takayuki Narushima

JOURNAL OF MATERIALS SCIENCE　46　(9)　2998-3005　2011/05

DOI： 10.1007/s10853-010-5177-x 　

ISSN： 0022-2461

eISSN： 1573-4803
Enhancement of nickel elution by lipopolysaccharide-induced inflammation Peer-reviewed

Rina Tanaka, Yoshiaki Goi, Kenji Ishihara, Kyosuke Ueda, Takayuki Narushima, Hiroshi Ohtsu, Masahiro Hiratsuka, Noriyasu Hirasawa

JOURNAL OF DERMATOLOGICAL SCIENCE　62　(1)　50-57　2011/04

DOI： 10.1016/j.jdermsci.2010.12.006 　

ISSN： 0923-1811

eISSN： 1873-569X
Precipitates in Biomedical Co-Cr-Mo-C-Si-Mn Alloys Peer-reviewed

T. Narushima, Alfirano, S. Mineta, S. Namba, T. Yoneda, K. Ueda

ADVANCED MATERIALS RESEARCH QIR 12　277　51-+　2011

DOI： 10.4028/www.scientific.net/AMR.277.51 　

ISSN： 1022-6680
Assessment of the release of nickel from biomaterials in vivo and in vitro: enhancement by lipopolysaccharide Peer-reviewed

R. Tanaka, Y. Goi, K. Ishihara, K. Ueda, T. Narushima, H. Ohtsu, K. Ohuchi, M. Hiratsuka, N. Hirasawa

Inflam. Regene.　31　(3)　302-306　2010/11/09
Publisher: The Japanese Society of Inflammation and Regeneration
DOI： 10.2492/inflammregen.31.302 　

ISSN： 1880-9693

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Biodevices are implanted for long periods of time, so the release of metal ions from alloys should be tested in tissues to assess the risk of inducing metal allergies. However there is little evidence that the release of metal ions from alloys in vivo is similar to that in vitro. We implanted metal wires in mice and determined the concentration of metal ions in tissue to analyze the mechanisms responsible for metal allergies. The release of ions from the Ni wire was detected within 8 h and attained a plateau 72 h after the implantation. Furthermore, it was significantly increased by an injection of LPS. The results indicated that the release of Ni was apparently enhanced by inflammatory responses. We also established an in vitro assay system using the murine macrophage cell line RAW 264. The addition of LPS apparently increased the amount of Ni released into the medium, indicating the activation of the cells to have enhanced the elution of ions from the Ni plate. Our in vitro model using LPS-stimulated RAW264 cells might reflect the elution of Ni in inflamed tissue.
Carbide Formation and Dissolution in Biomedical Co-Cr-Mo Alloys with Different Carbon Contents during Solution Treatment Peer-reviewed

Shingo Mineta, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE　41A　(8)　2129-2138　2010/08

DOI： 10.1007/s11661-010-0227-1 　

ISSN： 1073-5623
Surface modification of titanium by pack cementation treatment using calcium phosphate powders for biomedical applications Peer-reviewed

Kyosuke Ueda, Hajime Suto, Takayuki Narushima

METALS AND MATERIALS INTERNATIONAL　16　(4)　569-572　2010/08

DOI： 10.1007/s12540-010-0808-y 　

ISSN： 1598-9623
Calcium phosphate coating on titanium for improving biocompatibility with bone Invited Peer-reviewed

K. Ueda

Journal of Japan Institute of Light Metals　60　(7)　347-350　2010/08
Calcium phosphate coating for biomedical applications and its future Invited Peer-reviewed

K. Ueda

Journal of Japan Society of Biomaterials　28　(3)　159-160　2010/07
Fabrication and evaluation of multi-layered calcium phosphate coating film on titanium Peer-reviewed

Kyosuke Ueda, Yuuki Kawasaki, Takashi Goto, Jun Kurihara, Hiroshi Kawamura, Takayuki Narushima

Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy　57　(5)　314-320　2010/05

DOI： 10.2497/jjspm.57.314 　

ISSN： 0532-8799
Phase and Morphology of Carbides in ASTM F75 Co-Cr-Mo-C Alloys Formed at 1473 to 1623 K Peer-reviewed

Shingo Mineta, Alfi Rano, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

PRICM 7, PTS 1-3　654-656　2176-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2176 　

ISSN： 0255-5476
Heat Treatment of ASTM F75 Co-Cr-Mo-C-Si-Mn Alloys Peer-reviewed

Alfirano, Shingo Mineta, Shigenobu Namba, Takashi Yoneda, Kyosuke Ueda, Takayuki Narushima

PRICM 7, PTS 1-3　654-656　2180-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2180 　

ISSN： 0255-5476
Pack Cementation Treatment of Titanium Using Tetracalcium Phosphate Powder for Biomedical Applications Peer-reviewed

Kyosuke Ueda, Hajime Suto, Kaori Nakaie, Takayuki Narushima

PRICM 7, PTS 1-3　654-656　2172-2175　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2172 　

ISSN： 0255-5476
Calcium Phosphate Coating on Titanium Using Dry Process Peer-reviewed

Takayuki Narushima, Kyosuke Ueda, Takashi Goto, Jun Kurihara, Hiroshi Kawamura

PRICM 7, PTS 1-3　654-656　2162-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2162 　

ISSN： 0255-5476
Calcium Phosphate Coating on Blast-treated Titanium Implants by RF Magnetron Sputtering Peer-reviewed

K. Ueda, T. Narushima, T. Goto, T. Katsube, H. Nakagawa, H. Kawamura, M. Taira

MULTISCALE, MULTIFUNCTIONAL AND FUNCTIONALLY GRADED MATERIALS　631-632　211-+　2010

DOI： 10.4028/www.scientific.net/MSF.631-632.211 　

ISSN： 0255-5476
Preparation of functionally graded bio-ceramic film by MOCVD Peer-reviewed

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

MULTISCALE, MULTIFUNCTIONAL AND FUNCTIONALLY GRADED MATERIALS　631-632　193-+　2010

DOI： 10.4028/www.scientific.net/MSF.631-632.193 　

ISSN： 0255-5476
Changes in microstructure of biomedical Co-Cr-Mo-C alloys with solution treating and aging Peer-reviewed

S. Mineta, S. Namba, T. Yoneda, K. Ueda, T. Narushima

THERMEC 2009 SUPPLEMENT　89-91　377-+　2010

DOI： 10.4028/www.scientific.net/AMR.89-91.377 　

ISSN： 1022-6680
Behavior of precipitates in biomedical Co-Cr-Mo-C alloys during heat treatment Peer-reviewed

S. Mineta, Alfirano, S. Namba, T. Yoneda, K. Ueda, T. Narushima

Processing and Fabrication of Advanced Materials XVIII　3　1301-1310　2009/12
Effect of addition of alloying elements on microstructure of biomedical Co-Cr-Mo alloy Peer-reviewed

Alfirano, S. Mineta, S. Namba, T. Yoneda, K. Ueda, T. Narushima

Processing and Fabrication of Advanced Materials XVIII　3　1455-1464　2009/12
Precipitation Behavior in a Hanks' Solution on Ca-P-O Films Prepared by Laser CVD Peer-reviewed

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

MATERIALS TRANSACTIONS　50　(10)　2455-2459　2009/10

DOI： 10.2320/matertrans.M2009160 　

ISSN： 1345-9678

eISSN： 1347-5320
Fatigue Behaviors of Ultra Fine Wires of beta-Type and alpha-Type Titanium Alloys Peer-reviewed

Satoshi Yonezawa, Takayuki Narushima, Kyosuke Ueda, Hisamichi Kimura, Chiaki Ouchi, Yasutaka Iguchi

MATERIALS TRANSACTIONS　50　(7)　1713-1719　2009/07

DOI： 10.2320/matertrans.MF200920 　

ISSN： 1345-9678

eISSN： 1347-5320
Apatite formation behavior on bio-ceramic films prepared by MOCVD Peer-reviewed

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　117　(1364)　461-465　2009/04

DOI： 10.2109/jcersj2.117.461 　

ISSN： 1882-0743

eISSN： 1348-6535
Surface modification of titanium by dry process for biomedical applications Peer-reviewed

T. Narushima, K. Ueda, T. Goto

Proceedings of the 9th International Symposium on Biomaterials　22-27　2009
Calcium phosphate films with/without heat treatments fabricated using RF magnetron sputtering Peer-reviewed

Kyosuke Ueda, Yuuki Kawasaki, Takayuki Narushima, Takashi Goto, Jun Kurihara, Hironobu Nakagawa, Hiroshi Kawamura, Masayuki Taira

Journal of Biomechanical Science and Engineering　4　(3)　392-403　2009

DOI： 10.1299/jbse.4.392 　

ISSN： 1880-9863
Hydroxyapatite formation on Ca-P-O coating prepared by MOCVD Peer-reviewed

M. Sato, R. Tu, T. Goto, K. Ueda, T. Narushima

Mater. Trans.　49　(8)　1848-1852　2008/08

DOI： 10.2320/matertrans.MRA2008097 　

ISSN： 1345-9678

eISSN： 1347-5320
Fabrication and evaluation of calcium phosphate coating films on blast-treated Ti-6Al-4V alloy substrate Peer-reviewed

Takayuki Narushima, Kyosuke Ueda, Takashi Goto, Tomoyuki Katsube, Hiroshi Kawamura, Hironobu Nakagawa, Masayuki Taira

Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy　55　(5)　318-324　2008/05

DOI： 10.2497/jjspm.55.318 　

ISSN： 0532-8799
Preparation of Ca-Ti-O/Ca-P-O functionally graded bio-ceramic film by MOCVD Peer-reviewed

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy　55　(5)　325-330　2008/05

DOI： 10.2497/jjspm.55.325 　

ISSN： 0532-8799
RFマグネトロンスパッタリング法を用いた吸収性薄層リン酸カルシウムコーティングインプラントに関する実験的研究 Peer-reviewed

H. Nakagawa, T. Katsube, K. Ueda, J. Kurihara, T. Goto, T. Narushima, H. Kawamura

Japanese Journal of Maxillo Facial Implants　7　(1)　3-13　2008
In vitro and in vivo evaluations of calcium phosphate films on titanium fabricated using RF magnetron sputtering Peer-reviewed

K. Ueda, T. Narushima, T. Katsube, M. Taira, H. Kawamura, T. Goto

International Symposium on Interdisciplinary Science of Nanomaterials, Abstract books　2007/12
Evaluation of amorphous calcium phosphate coating films fabricated on titanium by RF magnetron sputtering Peer-reviewed

K. Ueda, T. Narushima, T. Goto, H. Nakagawa, H. Kawamura, T. Katsube

1st Asian Biomaterials Congress, Abstract　47　2007/12
Fabrication of calcium phosphate films for coating on titanium substrates heated up to 773 K by RF magnetron sputtering and their evaluations Peer-reviewed

Kyosuke Ueda, Takayuki Narushima, Takashi Goto, Masayuki Taira, Tomoyuki Katsube

BIOMEDICAL MATERIALS　2　(3)　S160-S166　2007/09

DOI： 10.1088/1748-6041/2/3/S14 　

ISSN： 1748-6041
Hydroxyapatite formation on CaTiO3 film prepared by metal-organic chemical vapor deposition Peer-reviewed

M. Sato, R. Tu, T. Goto, K. Ueda, T. Narushima

Mater. Trans.　48　(6)　1505-1510　2007/06

DOI： 10.2320/matertrans.MRA2007016 　

ISSN： 1345-9678

eISSN： 1347-5320
In vivo and in vitro evaluations of calcium phosphate films coated on titanium by RF magnetron sputtering Peer-reviewed

K. Ueda, T. Narushima, T. Goto, H. Nakagawa, H. Kawamura, T. Katsube

Ti-2007, Science and Technology, Proc. the 11th World Conference on Titanium (JIMIC-5)　1477-1480　2007/06
Fatigue properties of titanium wires for medical applications Peer-reviewed

T. Narushima, K. Ueda, T. Kinami, H. Kimura, C. Ouchi, Y. Iguchi

International Symposium on Interdisciplinary Science of Nanomaterials, Abstract books　1505-1508　2007/06
Evaluation of calcium phosphate coating films on titanium fabricated using RF magnetron sputtering Peer-reviewed

Kyosuke Ueda, Takayuki Narushima, Takashi Goto, Tomoyuki Katsube, Hironobu Nakagawa, Hiroshi Kawamura, Masayuki Taira

MATERIALS TRANSACTIONS　48　(3)　307-312　2007/03

DOI： 10.2320/matertrans.48.307 　

ISSN： 1345-9678

eISSN： 1347-5320
Hydroxyapatite formation on MOCVD-CaTiO3 coated Ti Peer-reviewed

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

INNOVATION IN CERAMICS SCIENCE AND ENGINEERING　352　301-+　2007

DOI： 10.4028/www.scientific.net/KEM.352.301 　

ISSN： 1013-9826
Hydroxyapatite formation on calcium phosphate coated titanium Peer-reviewed

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

PRICM 6: SIXTH PACIFIC RIM INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS AND PROCESSING, PTS 1-3　561-565　(PART 2)　1513-+　2007

DOI： 10.4028/www.scientific.net/MSF.561-565.1513 　

ISSN： 0255-5476
Calcium phosphate films coated on titanium by RF magnetron sputtering for medical applications Peer-reviewed

T. Narushima, K. Ueda, T. Goto, T. Katsube, H. Kawamura, C. Ouchi, Y. Iguchi

THERMEC 2006, PTS 1-5　539-543　(PART 1)　551-+　2007

DOI： 10.4028/www.scientific.net/MSF.539-543.551 　

ISSN： 0255-5476
Hydroxyapatite formation on MOCVD-CaTiO3 coated Ti Peer-reviewed

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

INNOVATION IN CERAMICS SCIENCE AND ENGINEERING　352　301-+　2007

DOI： 10.4028/0-87849-454-5.301 　

ISSN： 1013-9826
In vitro evaluations of RF magnetron-sputtered calcium phosphate films on titanium Peer-reviewed

Kyosuke Ueda, Takayuki Narushima, Tomoyuki Katsube, Hiroshi Kawamura, Takashi Goto

INNOVATION IN CERAMICS SCIENCE AND ENGINEERING　352　305-+　2007

DOI： 10.4028/0-87849-454-5.305 　

ISSN： 1013-9826
In vitro evaluations of RF magnetron-sputtered calcium phosphate films on titanium Peer-reviewed

Kyosuke Ueda, Takayuki Narushima, Tomoyuki Katsube, Hiroshi Kawamura, Takashi Goto

INNOVATION IN CERAMICS SCIENCE AND ENGINEERING　352　305-+　2007

DOI： 10.4028/www.scientific.net/KEM.352.305 　

ISSN： 1013-9826
Preparation of Graded Biocompatible Films by MOCVD Peer-reviewed

M. Sato, R. Tu, T. Goto, K. Ueda, T. Narushima

傾斜機能材料論文集　20　109-114　2006
Characterization of calcium phosphate films prepared by RF magnetron sputtering Peer-reviewed

Takayuki Narushima, Kyosuke Ueda, Takashi Goto, Tomoyuki Katsube, Hiroshi Kawamura, Chiaki Ouchi, Yasutaka Iguchi

MATERIAL AND DEVICES FOR SMART SYSTEMS II　888　101-+　2006

ISSN： 0272-9172
Preparation of calcium phosphate films by radiofrequency magnetron sputtering Peer-reviewed

T Narushima, K Ueda, T Goto, H Masumoto, T Katsube, H Kawamura, C Ouchi, Y Iguchi

MATERIALS TRANSACTIONS　46　(10)　2246-2252　2005/10

DOI： 10.2320/matertrans.46.2246 　

ISSN： 1345-9678

eISSN： 1347-5320
Preferred orientation of calcium phosphate films prepared by RF magnetron sputtering Peer-reviewed

K. Ueda, T. Narushima, T. Goto, T. Katsube, H. Kawamura, C. Ouchi, Y. Iguchi

Archives of BioCeramics Research　5　59-62　2005/09/20
Development of dental and medical systems for reconstruction of human body with high performance titanium materials Peer-reviewed

Tomoyuki Katsube, Kyosuke Ueda, Takayuki Narushima, Takashi Goto, Yasutaka Iguchi, Hiroshi Kawamura

International Congress Series　1284　324-325　2005/09

DOI： 10.1016/j.ics.2005.06.067 　

ISSN： 0531-5131
Wear loss and elution of CPTi and titanium alloys in simulated body fluids Peer-reviewed

K Ueda, T Narushima, C Ouchi, Y Iguchi

PRICM 5: THE FIFTH PACIFIC RIM INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS AND PROCESSING, PTS 1-5　475-479　(III)　2333-2336　2005

DOI： 10.4028/www.scientific.net/MSF.475-479.2333 　

ISSN： 0255-5476
Evaluation of fatigue property of titanium wires by rotating-bending testing in 1 mass% lactic acid solution Peer-reviewed

T. Narushima, K. Ueda, M. Yamashita, T. Murakami, C. Ouchi, Y. Iguchi

Proc. of International Functional Electrical Stimulation Society　2004　416-418　2004/09/09

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Misc. 52

年間レビューチタン・チタン合金 Peer-reviewed

上田恭介, 石本卓也

軽金属　74　397-399　2024/08
チタンへの抗菌性付与を目指した可視光応答型光触媒TiO2膜の作製と評価 Peer-reviewed

上田恭介, 成島尚之, 古泉隆佑

金属　94　233-238　2024/03
年間レビューチタン・チタン合金 Peer-reviewed

上田恭介, 石本卓也

軽金属　73　(8)　432-435　2023/08
Technology Development Results on Biomedical Materials with High Purity Magnesium Peer-reviewed

Makoto Inoue, Kyosuke Ueda, Takahiro Mineta, Tetsuo Aida, Minoru Matsushima, Kazuyoshi Yamaguchi

Materia Japan　62　(2)　93-98　2023/02/01
Publisher: Japan Institute of Metals
DOI： 10.2320/materia.62.93 　

ISSN： 1340-2625

eISSN： 1884-5843
Co-Cr-Al-Si合金の高い弾性異方性と単結晶における低いヤング率

許きょう, 許きょう, 大平拓実, 大平拓実, 許勝, 平田研二, 平田研二, 大森俊洋, 植木洸輔, 植木洸輔, 上田恭介, 成島尚之, 長迫実, HARJO Stefanus, 川崎卓郎, BODNAROVA Lucie, SEDLAK Petr, SEINER Hanus, 貝沼亮介

日本金属学会講演大会(Web)　173rd　2023
Co-Cr-Al-Si superelastic alloys with low Young’s modulus

XU Xiao, XU Xiao, 大平拓実, 大平拓実, XU Sheng, 平田研二, 平田研二, 大森俊洋, 植木洸輔, 植木洸輔, 上田恭介, 成島尚之, 長迫実, HARJO Stefanus, 川崎卓郎, BODNAROVA Lucie, SEDLAK Petr, SEINER Hanus, 貝沼亮介

材料とプロセス(CD-ROM)　35　(2)　2022

ISSN： 1882-8922
Antibacterial Surface Treatment of Titanium Alloys Peer-reviewed

Takayuki NARUSHIMA, Kyosuke UEDA, Ryusuke KOIZUMI

Journal of The Surface Finishing Society of Japan　72　(11)　616-621　2021/11/01
Publisher: The Surface Finishing Society of Japan
DOI： 10.4139/sfj.72.616 　

ISSN： 0915-1869

eISSN： 1884-3409
レーザ積層造形法による高耐食ステンレス鋼の開発

堤祐介, 片山英樹, 石本卓也, 中野貴由, 上田恭介, 成島尚之, 真中智世, 塙隆夫

材料と環境講演集　2021　2021
Development of Ultrahigh Corrosion Resistant Metallic Materials ―Improvement of Corrosion Resistance of Martensitic Stainless Steel by Selective Laser Melting Process― Peer-reviewed

Yusuke Tsutsumi, Takuya Ishimoto, Kyosuke Ueda, Shinpei Maruyama, Tetsuji Kuse, Aira Matsugaki, Maki Ashida, Peng Chen

Materia Japan　59　(12)　679-684　2020/12/01
Publisher: Japan Institute of Metals
DOI： 10.2320/materia.59.679 　

ISSN： 1340-2625

eISSN： 1884-5843
Preface to the Special Issue on “Bioadaptive Materials, Design of Biomaterials Based on the Biological Mechanisms”

Kyosuke Ueda, Takuya Ishimoto, Yusuke Tsutsumi, Naoko Ikeo, Ken Cho, Kenta Yamanaka, Akiko Obata, Yoshihiro Noyama

Materia Japan　59　(11)　587-587　2020/11/01
Publisher: Japan Institute of Metals
DOI： 10.2320/materia.59.587 　

ISSN： 1340-2625

eISSN： 1884-5843
Antibacterial Functionalization of Ti-based Biomaterials Based on the Understanding of the Inactivation Mechanisms of Bacteria via Photocatalytic Activity of Titanium Oxide: Visible-light Responsive Reaction of Titanium Oxide Coating Invited Peer-reviewed

Kyosuke Ueda, Takatoshi Ueda, Takayuki Narushima

Materia Japan　59　(11)　612-617　2020/11/01
Publisher: Japan Institute of Metals
DOI： 10.2320/materia.59.612 　

ISSN： 1340-2625

eISSN： 1884-5843
Controlling Bio-dissolution of Amorphous Calcium Phosphate and Applying Antibacterial Activity to Ti using Bio-dissolved Amorphous Calcium Phosphate as a Carrier of Ag Peer-reviewed

K. Ueda, T. Narushima

38　(4)　242-247　2020/10
Formation of titania coating layer on Ti-Au alloy by thermal oxidation and its antibacterial property through photocatalytic activity under visible-light irradiation Invited Peer-reviewed

K. Ueda, T. Ueda, T. Narushima

JCS-Japan　55　(3)　2020/03
Ti-17合金の時効析出に及ぼす酸素濃度の影響

上田恭介, 福島涼太, 北嶋具教, 成島尚之

日本金属学会講演概要(CD-ROM)　164th　2019

ISSN： 2433-3093
Au蒸着Ti基板の大気酸化によるAu添加TiO₂膜の作製およびその可視光誘起抗菌能

上田隆統志, 佐藤直生, 上田恭介, 伊藤甲雄, 小笠原康悦, 目代貴之, 金高弘恭, 成島尚之

日本金属学会講演概要(CD-ROM)　164th　2019

ISSN： 2433-3093
Ti-Au合金表面に作製したAu添加TiO₂膜の可視光照射下における抗菌能

上田隆統志, 上田恭介, 伊藤甲雄, 小笠原康悦, 金高弘恭, 目代貴之, 目代貴之, 庭野吉己, 庭野吉己, 成島尚之

日本防菌防黴学会年次大会要旨集　46th　2019
No. 1 チタン (Titanium)

上田恭介

まてりあ　58　(1)　5-5　2019
Publisher: 公益社団法人日本金属学会
ISSN： 1340-2625
大気酸化によりTi‐Au合金表面に作製したTiO₂膜の可視光照射下における抗菌能およびラジカル生成

上田隆統志, 上田恭介, 伊藤甲雄, 小笠原康悦, 目代貴之, 金高弘恭, 庭野吉己, 成島尚之

日本金属学会講演概要(CD-ROM)　162nd　ROMBUNNO.217　2018/03/05

ISSN： 1342-5730
大気酸化によりTi-Au合金表面に作製したTiO₂膜の可視光照射下における抗菌能およびラジカル生成

上田隆統志, 上田恭介, 伊藤甲雄, 小笠原康悦, 目代貴之, 金高弘恭, 庭野吉己, 成島尚之

日本金属学会講演概要(CD-ROM)　162nd　2018

ISSN： 2433-3093
Coatings for Improving Bone Compatibility of Titanium

UEDA Kyosuke, UEDA Takatoshi, SATO Naoki, NARUSHIMA Takayuki

Journal of The Surface Finishing Society of Japan　69　(8)　341-345　2018
Publisher: 一般社団法人表面技術協会
ISSN： 0915-1869
At the Inception of the Project

Ttsutsumi Yusuke, Ueda Kyosuke

Materia Japan　57　(4)　139-139　2018
Publisher: 公益社団法人日本金属学会
ISSN： 1340-2625
Ag含有非晶質リン酸カルシウムコーティングによる硬組織代替デバイスへの抗菌性と骨形成能の付与

上田恭介, 井上紅花, 伊藤甲雄, 小笠原康悦, 成島尚之

日本骨形態計測学会雑誌　27　(1)　S140-S140　2017/05
Publisher: 日本骨形態計測学会
ISSN： 0917-4648
抗菌性をもつ生体材料開発

K. Ueda, T. Narushima

炎症と免疫　25　(2)　110-117　2017/02
電子ビーム積層造形(EBM)した生体用Co-Cr-Mo合金の組織と晶析出物分析

小泉雄一郎, 魏代修, 山中謙太, 千葉晶彦, 植木洸輔, 上田恭介, 成島尚之

日本金属学会講演概要(CD-ROM)　160th　2017

ISSN： 2433-3093
Ti-5Al-2Sn-2Zr-4Mo-4Cr(Ti-17)合金の大気中酸化挙動に及ぼすSi添加の影響

鈴木聡, 上田恭介, BHATTACHARYA S.K., 佐原亮二, 北嶋具教, 成島尚之

日本金属学会講演概要(CD-ROM)　160th　2017

ISSN： 2433-3093
History and Perspective of Metal-based Biomaterials

Koizumi Yuichiro, Ueda Kyosuke, Tsutsumi Yusuke, Ishimoto Takuya, Ohtsu Naofumi, Tanaka Yasuhiro

Materia Japan　56　(3)　204-204　2017
Publisher: 公益社団法人日本金属学会
DOI： 10.2320/materia.56.204 　

ISSN： 1340-2625
中堅研究者から見た金属系バイオマテリアルの現状とこれから

上田恭介

バイオマテリアル -生体材料-　34　(4)　268-279　2016/12
Present and Future of Metallic Biomaterials from Mid-level Researcher's Point of View

上田恭介

バイオマテリアル = Journal of Japanese Society for Biomaterials : 生体材料　34　(4)　268-271　2016/10
Publisher: 日本バイオマテリアル学会 ; 2002-
ISSN： 1347-7080
Ti-6Al-4V-xSi(x=0~1mass%)合金の耐酸化性と機械的特性

前田幸大, 上田恭介, 北嶋具教, 池田亜矢子, 萩原益夫, 佐原亮二, 御手洗容子, 成島尚之

日本金属学会講演概要(CD-ROM)　159th　2016

ISSN： 2433-3093
Ti-6242S合金の酸化挙動

池田亜矢子, 北嶋具教, 萩原益夫, 江村聡, 佐原亮二, 成島尚之, 上田恭介

日本金属学会講演概要(CD-ROM)　159th　2016

ISSN： 2433-3093
NiTi and Co-Cr alloys used in biomedical stents

T. Narushima, Alfirano, K. Ueda

Proceedings of 9th National Seminar of Metallurgy and Materials IX (SENAMM IX)　7-16　2016
Microstructure and Mechanical Property of alpha plus beta Type Ti-(0 similar to 10) mass%V-(0.5 similar to 1) mass%O Alloys

Kyosuke Ueda, Tatsuya Kobayashi, Takayuki Narushima

JOURNAL OF THE JAPAN INSTITUTE OF METALS　80　(1)　60-65　2016

DOI： 10.2320/jinstmet.JB201503 　

ISSN： 0021-4876

eISSN： 1880-6880
Surface treatment of titanium using thermal oxidation for biomedical applications

Takayuki Narushima, Kyosuke Ueda, Shota Sado

Zairyo to Kankyo/ Corrosion Engineering　63　(5)　295-300　2014
Publisher: Japan Society of Corrosion Engineering
DOI： 10.3323/jcorr.63.295 　

ISSN： 1881-9664 0917-0480
Osteoconduction by calcium phosphate coating

上田恭介, 成島尚之

日本骨形態計測学会雑誌　24　(1)　33-39　2014
Preface to Special Issue on Present and Future Requirements for Development of Biomedical Materials

Nakai Masaaki, Koizumi Yuichiro, Ueda Masato, Miura-Fujiwara Eri, Ohtsu Naofumi, Hiromoto Sachiko, Ishimoto Takuya, Ueda Kyosuke

Materia Japan　53　(4)　133-133　2014
Publisher: 公益社団法人日本金属学会
DOI： 10.2320/materia.53.133 　

ISSN： 1340-2625
Fabrication of Functional Surface on Metallic Biomaterials using Ceramic Coating

成島尚之, 上田恭介, 佐渡翔太

機能材料　33　(9)　33-39　2013/09
Publisher: シーエムシー出版
ISSN： 0286-4835
Precipitates in Biomedical Co-Cr Alloys

Takayuki Narushima, Shingo Mineta, Yuto Kurihara, Kyosuke Ueda

JOM　65　(4)　489-504　2013/04

DOI： 10.1007/s11837-013-0567-6 　

ISSN： 1047-4838
Calcium phosphate coating on titanium for improving biocompatibility with bone

上田恭介

Journal of Japan Institute of Light Metals　60　(7)　347-350　2010/07
Publisher: 軽金属学会
ISSN： 0451-5994
S0201-1-2 Formation of anatase film on titanium and its evaluation of bone compatibility

NARUSHIMA Takayuki, UEDA Kyosuke, OKAZUMI Takuro

The proceedings of the JSME annual meeting　2010　(0)　13-14　2010
Publisher: 一般社団法人日本機械学会
DOI： 10.1299/jsmemecjo.2010.5.0_13 　

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The oxide phase on Ti, TiO_2, is known to affect their properties. Anatase has been suggested to have excellent bone forming ability as compared to rutile. The anatase layer formation on Ti and its alloys by thermal oxidation could be the low-cost and simple surface treatment for improving their bone compatibility. We developed the two-step thermal oxidation process for the anatase layer formation on CP Ti. At the first-step, CP Ti is heat-treated in an Ar-CO atmosphere. At the second-step, the specimens were oxidized in air, and anatase-rich layer was obtained in the case of that oxycarbide (TiC_xO_y) single phase was formed at the first-step. The immersion tests in simulated body fluid showed that the anatase-rich layer improved the bone compatibility of CP Ti. The bonding strength between the anatase-rich layer and CP Ti was higher than 90 MPa.
The 1^<st> International Symposium on Advanced Synthesis and Processing Technology for Materials (ASPT08)

上田恭介

粉体および粉末冶金　56　(1)　35-36　2009/01/15

ISSN： 0532-8799
S109 Fabrication and Evaluation of Calcium Phosphate Coating Films on Blast-treated Ti-6Al-4V Substrate

NARUSHIMA Takayuki, UEDA Kyosuke, GOTO Takashi, KURIHARA Jun, NAKAGAWA Hironobu, KAWAMURA Hiroshi

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2008　(0)　331-332　2009
Publisher: 一般社団法人日本機械学会
S111 Effect of microstructure for apatite formation on Ca-P-O films prepared by CVD

SATO Mitsutaka, TU Rong, GOTO Takashi, UEDA Kyosuke, NARUSHIMA Takayuki

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2008　(0)　335-336　2009
Publisher: 一般社団法人日本機械学会
J0401-2-3 Evaluation of Calcium Phosphate Coating Film on Titanium Substrate

UEDA Kyosuke, KAWASAKI Yuuki, NARUSHIMA Takayuki, GOTO Takashi, KURIHARA Jun, KAWAMURA Hiroshi

The proceedings of the JSME annual meeting　2009　(0)　271-272　2009
Publisher: 一般社団法人日本機械学会
DOI： 10.1299/jsmemecjo.2009.6.0_271 　

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Amorphous calcium phosphate (ACP), oxyapatite (Ca_<10>(PO_4)_6O, OAp), heat-treated OAp (OAp-AIR) and OAp/OAp-AIR double layer (D-layer) coating films were fabricated on the surface of the titanium substrates using RF magnetron sputtering. The cross sectional observation before and after the implantation, bonding strength between coating film and substrates and removal torques from femur of Japanese white rabbits were examined. The bonding strength between coating films and substrates were more than 50 MPa, and removal torque of coated implants from the femur of Japanese white rabbits were greater than that of uncoated one. After the implantation of ACP coating film, the coating would be dissolved into the body and it caused the high biocompatibility of bone.
レーザーCVD法により合成したリン酸カルシウム膜のアパタイト形成能

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

日本金属学会講演概要　142nd　2008

ISSN： 1342-5730
レーザーCVD法により合成したHAp膜上へのアパタイト形成の結晶配向依存性

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

日本金属学会講演概要　143rd　2008

ISSN： 1342-5730
Erratum:Fabrication and Evaluation of Calcium Phosphate Coating Films on Blast-treated Ti-6Al-4V Alloy Substrate

Narushima Takayuki, Ueda Kyosuke, Goto Takashi, Katsube Tomoyuki, Kawamura Hiroshi, Nakagawa Hironobu, Taira Masayuki

Journal of the Japan Society of Powder and Powder Metallurgy　55　(7)　551-551　2008
Publisher: 一般社団法人粉体粉末冶金協会
ISSN： 0532-8799

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About the paper by Takayuki Narushima et al. published in the May 2008 issue of the Journal, the authors requested that some errors in the Table 1 (p322) of the original paper should be corrected.
MOCVD法によるCa-Ti-OおよびCa-P-O傾斜機能バイオセラミックス膜の合成

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

粉体粉末冶金協会講演概要集　2007　2007
MOCVD法により合成したCa-P-O膜上への擬似体液中におけるアパタイト形成

佐藤充孝, TU R., 後藤孝, 上田恭介, 成島尚之

セラミックス基礎科学討論会講演要旨集　45th　2007
MOCVD法により合成したCa-P-O膜の擬似体液中におけるHAp形成

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

日本金属学会講演概要　140th　2007

ISSN： 1342-5730
Effect of oxygen partial pressure on electrical conductivity of Ca-Ru-O compounds prepared by spark plasma sintering

Mitsutaka Sato, Rong Tu, Takashi Goto, Kyosuke Ueda, Takayuki Narushima

Materials Science Forum　561-565　(0)　595-598　2007
ハーモニックバイオマテリアル-界面制御型生体調和材料創製の可能性-MOCVD法により合成したCaTiO₃膜の擬似体液中におけるHAp形成

佐藤充孝, 塗溶, 後藤孝, 上田恭介, 成島尚之

日本金属学会講演概要　138th　2006

ISSN： 1342-5730
Growth of HAp on the CVD CaTiO₃ film in Hank's solution

Tu Rong, Sato Mitsutaka, Goto Takashi, Ueda Kyosuke, Narushima Takayuki

Preprints of Annual Meeting of The Ceramic Society of Japan Preprints of Fall Meeting of The Ceramic Society of Japan　2006　(0)　591-591　2006
Publisher: 公益社団法人日本セラミックス協会

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縦型コールドウォール式ＣＶＤ装置を用い、Ca(dpm)2およびTi(OiPr)2(dpm)2によりCaTiO3膜を作製した。基板温度が973、1073 Kでは原料モル比が約1のとき、CaTiO3単一相が得られたが、873 KではCaTiO3とCaOの混合相が得られた。膜の微細組織波、基板温度の上昇に伴いCaTiO3膜の断面組織は緻密構造から柱状晶へと変化した。成膜速度は基板温度の上昇および反応室内圧力の減少とともに増大し、基板温度1073 K、反応室内圧力0.4 kPaでは最大であった。ハンクス溶液中におけるHApの生成を調べた。

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Books and Other Publications 10

製品利用に向けたバイオマテリアル開発の基本事項と注意点―材料の特徴・材料劣化・表面解析・安全性試験・ニーズ収集―

上田恭介, 成島尚之

情報機構　2022/06

ISBN: 9784865022360
Phosphate and Borate Bioactive Glasses

K. Ueda, T. Narushima

Royal Society of Chemistry　2022/05/04

DOI： 10.1039/9781839164750-00114 　

ISBN: 1839161647
無機/有機材料の表面処理・改質による生体適合性付与

上田恭介, 佐藤直生, 成島尚之

2019

ISBN: 9784781314150
歯科再生・修復医療と材料

成島尚之, 上田恭介, 上田隆統志, 佐渡翔太

シーエムシー出版　2015/08

ISBN: 9784781310848
Advances in Metallic Biomaterials, Springer Series in Biomaterials Science and Engineering 4

Masahiro Hirohashi, Kyosuke Ueda, Takeshi Wada, Takayuki Narushima, Hidemi Kato

Springer　2015
Interface Oral Health Science 2014, Innovative Research on Biosis-Abiosis Intelligent InterfaceInterface Oral Health Science 2014, Innovative Research on Biosis-Abiosis Intelligent Interface

T. Narushima, S. Sado, N. Kondo, K. Ueda, M. Kawano, K. Ogasawara

2015
Advances in Metallic Biomaterials, Springer Series in Biomaterials Science and Engineering 3

Takayuki Narushima, Kyosuke Ueda, Alfirano

Springer　2015
バイオマテリアル研究の最前線

上田恭介

日本金属学会　2014/09
Technological Advancements in Biomedicine for Healthcare Applications

T. Narushima, K. Ueda

IGI Global　2012/10
CRC Handbook of Biological and Biomedical Coatings

T. Goto, T. Narushima, K. Ueda

CRC Press　2011/07

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Presentations 141

二段階熱酸化法による炭素・窒素共添加TiO2膜の作製および可視光照射下における抗菌性評価

上田恭介, 古泉隆佑, 伊藤甲雄, 小笠原康悦, 金髙弘恭, 目代貴之, 成島尚之

国際・産学連携インヴァースイノベーション材料創出プロジェクト-DEJI²MAプロジェクト-Design & Engineering by Joint Inverse Innovation for Materials Architecture（６大学連携プロジェクト）第1回公開討論会　2023/03/11
生体用Co-Cr-Fe-Mo系合金の微細組織と機械的特性に及ぼすNi含有量の影響

檜山快, 植木洸輔, 上田恭介, 成島尚之

日本金属学会2023年春期(第172回)講演大会　2023/03/10
NaOH処理チタン表面へのゾルゲル・ディップ法による生体活性ガラス膜コーティング

上田恭介, Alexander M. Samuel, Julian Jones, 成島尚之

日本金属学会2023年春期(第172回)講演大会　2023/03/10
計算材料科学によるチタン表面酸化に及ぼす合金元素の影響評価

佐原亮二, K. Kohli, S. Kr. Bhattacharya, P. Ghosh, 上田恭介, 成島尚之

日本金属学会2023年春期(第172回)講演大会　2023/03/09
新型コロナウイルススパイクタンパク質の不活化評価法の確立

古泉隆佑, 井越翔太, 上田恭介, 伊藤甲雄, 小笠原康悦, 成島尚之

日本金属学会2023年春期(第172回)講演大会　2023/03/10
医療用高純度Mg-Zn合金の作製

真田凌弥, 井上誠, 岡根正樹, 喜多正雄, 青柳成俊, 中田大貴, 上田恭介

資源・素材学会関西支部第19回「若手研究者・学生のための研究発表会」　2022/12/09
真空蒸留法による高純度Mg-Zn合金の作製

真田凌弥, 井上誠, 岡根正樹, 橋本安弘, 青柳成俊, 中田大貴, 上田恭介

日本金属学会北陸信越支部・日本鉄鋼協会北陸信越支部令和4年度連合講演会　2022/12/03
新型コロナウイルススパイクタンパク質の定量方法確立

井越翔太, 古泉隆佑, 上田恭介, 伊藤甲雄, 小笠原康悦, 成島尚之

2022年度東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会「臨床応用へ向けたバイオマテリアルサイエンス」　2022/10/26
Preparation of bioactive glass layers on NaOH-treated Ti substrates via sol-gel dip coating method

Alexander Samuel, Kyosuke Ueda, Takayuki Narushima

2022/10/26
低ヤング率を有するCo-Cr-Al-Si超弾性合金 International-coauthorship

許皛, 大平拓実, 許勝, 平田研二, 大森俊洋, 植木洸輔, 上田恭介, 成島尚之, 長迫実, Stefanus Harjo, 川崎卓郎, Lucie Bodnárová, Petr Sedlák, Hanuš Seiner, 貝沼亮介

日本金属学会2022年秋期(第171回)講演大会　2022/09/23
希土類元素添加によるNiTiの非金属介在物制御

上田恭介, 柴﨑大侑, 山下史祥, 成島尚之

日本金属学会2022年秋期(第171回)講演大会　2022/09/23
全電子混合基底法GW計算による軽元素添加TiO2の電子状態計算

佐原亮二, 石川立, 大野かおる, 上田恭介, 成島尚之

日本金属学会2022年秋期(第171回)講演大会　2022/09/23
高いX線造影性を有するステント用Co-Cr-Ni-Pt-W系合金開発

本田有作, 植木洸輔, 上田恭介, 成島尚之

日本金属学会2022年秋期(第171回)講演大会　2022/09/21
光触媒活性TiO2膜の抗菌性に及ぼす可視光照射条件の影響

古泉隆佑, 上田恭介, 伊藤甲雄, 小笠原康悦, 成島尚之

日本金属学会2022年秋期(第171回)講演大会　2022/09/21
生体用Co-Cr-Fe-Ni-Mo合金の微細組織および機械的特性に及ぼす加工熱処理の影響

檜山快, 植木洸輔, 上田恭介, 成島尚之

日本金属学会2022年秋期(第171回)講演大会　2022/09/20
生体用Co-Cr-W-Ni合金におけるFe添加が気化相手機特性および耐食性に与える影響

肥田輝, 植木洸輔, 上田恭介, 成島尚之, 仲井正昭

日本金属学会2022年秋期(第171回)講演大会　2022/09/20
生体用Co-Cr-Moの析出物に及ぼす加工熱処理の影響

橋本航, 上田恭介, 成島尚之

日本金属学会2022年秋期(第171回)講演大会　2022/09/20
Effect of carbon contents on the microstructure of Co-Cr-W-Ni alloys for stent applications International-presentation

Kyosuke Ueda, Sukma Suci Friandani, Takayuki Narushima

Interface Summer Seminar 2022, The 17th International Workshop on Biomaterials in Interface Science　2022/08/24
二段階熱酸化法によりチタン合金上に作製した可視光応答型炭素含有アナターゼ型TiO2膜の抗菌性評価

上田恭介, 成島尚之

令和4年度第79回日本歯科理工学会学術講演会　2022/05/22
Mechanisms of oxidation of pure and Si-segregated Ti surfaces International-presentation

Ryoji Sahara, Somesh, Kr. Bhattacharya, Kyosuke Ueda, Takayuki Narushima

2nd International Conference on Materials Genome (ICMG-II)　2022/03/24
Siを添加したTi-5Al-2Sn-2Zr-4Mo-4Cr (Ti-17)合金の大気中酸化・窒化挙動

成島尚之, 上田恭介, 鈴木聡, 佐原亮二, Somesh Kr. Bhattacharya

日本鉄鋼協会第183回春季講演大会　2022/03/17
Microstructure of Biomedical Co-Cr-W-Ni Alloys with Carbon Addition during Heat Treatment

Sukma Suci Friandani, Kyosuke Ueda, Takayuki Narushima

2022/03/17
二段階法により作製したTiO2膜の構造および光触媒活性に及ぼす酸化処理条件の影響

古泉隆佑, 上田恭介, 伊藤甲雄, 小笠原康悦, 成島尚之

日本金属学会第170回大会(2022年春期)　2022/03/15
生体用金属・セラミックス系材料の生体外評価の現状と課題

上田恭介

日本金属学会第170回大会(2022年春期)　2022/03/16
Formation of visible-light-responsive TiO2 layers on practical dental titanium alloys by two-step thermal oxidation and their antibacterial properties International-presentation

Kyosuke Ueda, Ryusuke Koizumi, Takatoshi Ueda, Naoki Sato, Koyu Ito, Kouetsu Ogasawara, Takayuki Narushima

Joint Symposium on Society for Biomaterials and Japanese Society for Biomaterials　2022/01/08
ステント用NiTi合金の微細組織に及ぼす希土類添加の影響

柴﨑大侑, 上田恭介, 成島尚之

令和3年度第20回日本金属学会東北支部研究発表大会　2021/12/17
X線造影性を有するステント用Co-Cr-W-Pt系合金の微細組織

本田有作, 上田恭介, 成島尚之

第4回日本金属学会第7分野講演会「金属系バイオマテリアルサイエンスの新展開(III)」　2021/12/11
生体用Co-Cr-Mo合金の析出挙動に及ぼす加工熱処理の影響

橋本航, 上田恭介, 成島尚之

第4回日本金属学会第7分野講演会「金属系バイオマテリアルサイエンスの新展開(III)」　2021/12/11
Change in microstructure of biomedical Co-Cr-W-Ni alloys with C addition

Sukma Suci Friandani, Kyosuke Ueda, Takayuki Narushima

2021/12/11
チタンの二段階熱酸化法による可視光応答型TiO2膜の作製とその抗菌性評価

上田恭介, 古泉隆佑, 成島尚之

第９回日本チタン協会「チタン研究者・技術者研究交流会」、第１回日本チタン学会講演大会　2021/11/04
ステント用Co-Cr合金チューブの機械的特性

武田春星, 植木洸輔, 上田恭介, 成島尚之

2021年度東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会バイオマテリアル研究の深化：セオリーとアプリケーション　2021/09/29
Antibacterial functionalization of titanium surface by the formation of visible light responsive photocatalytic TiO2 layer

R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, M. Furuya, H. Kanetaka, T. Narushima

The 16th International Workshop on Biomaterials in Interface Science　2021/09/28
真空蒸留法により作製したMg-Zn合金の擬似体液中における表面反応

上田恭介, 徳永悠介, 成島尚之, 井上誠

日本金属学会第169回大会(2021年秋期)　2021/09/17
チタン表面に作成した炭素含有TiO2膜の短時間可視光照射条件における抗菌性評価

古泉隆祐, 島田啓太, 上田恭介, 伊藤甲雄, 小笠原康悦, 古谷真衣子, 金髙弘恭, 成島尚之

日本金属学会第169回大会(2021年秋期)　2021/09/15
レーザ積層造形法による高耐食ステンレス鋼の開発

堤祐介, 片山秀樹, 石本卓也, 中野貴由, 上田恭介, 成島尚之, 真中知世, 塙隆夫

材料と環境2021　2021/05/19
二段階熱酸化により作製した窒素含有TiO2膜の可視光照射誘起抗菌性および細胞毒性評価

古泉隆祐, 島田啓太, 上田恭介, 伊藤甲雄, 小笠原康悦, 古谷真衣子, 金髙弘恭, 成島尚之

日本金属学会第168回大会(2021年春期)　2021/03/19
Ag, Ta共添加非晶質リン酸カルシウム膜からのAgイオン放出制御と抗菌性

上田恭介, Wu Jun, 伊藤甲雄, 小笠原康悦, 古谷真衣子, 金髙弘恭, 成島尚之

日本金属学会第168回大会(2021年春期)　2021/03/19
Effect of Ta addition on the antibacterial activity and cytotoxicity of Ag-containing amorphous calcium phosphate coating film

K. Ueda, J. Wu, K. Ito, K. Ogasawara, M. Furuya, K. Yokota, H. Kanetaka, T. Narushima

International Joint Symposium 2020, The 15th International Workshop on Biomaterials in Interface Science, The 11th Symposium on Innovative Dental-Engineering Alliance (IDEA)　2020/12/14
Antibacterial activity of Ag-Ta co-containing amorphous calcium phosphate coating films

K. Ueda, J. Wu, K. Ito, K. Ogasawara, H. Kanetaka, T. Narushima

11th World Biomaterials Congress　2020/12/11
Evaluation of long-term antibacterial activity of Ag-containing amorphous calcium phosphate films with various Ta contents

Jun Wu, 上田恭介, 伊藤甲雄, 小笠原康悦, 金髙弘恭, 成島尚之

第3回日本金属学会第7分野講演会「金属系バイオマテリアルサイエンスの新展開(III)」　2020/12/12
2段階熱酸化法による窒素添加酸化チタン膜の作製とその抗菌性評価

上田恭介, 上田隆統志, 佐藤直生, 古泉隆祐, 目代貴之, 伊藤甲雄, 小笠原康悦, 金髙弘恭, 成島尚之

2020/11/30
Visible-light-induced antibacterial activity of TiO2 layer formed by the two-step thermal oxidation of Ti

R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, T. Narushima

The 4th Symposium for The Core Research Cluster for Materials Science and the 3rd Symposium on International Joint Graduate Program in Materials Science “Create New Value of Materials Science through Broad Collaboration”　2020/11/17
Preparation of ultra high purity magnesium sheet by vacuum distillation, extrusion and forging

K. Mizuhara, M. Inoue, T. Aida, K. Ueda, T. Mineta, H. Miura

The 5th International Conference on “Science of Technology Innovation” 2020 (5th STI-Gigaku2020)　2020/10/30
新型コロナウイルス由来タンパク質を利用した不活化評価方法の確立と可視光応答型光触媒によるウイルス不活化表面の創製

2020/10/26
チタン融体の脱酸挙動に及ぼすプラズマアーク溶解条件の検討

阿部来紀, 上田恭介, 松若大介, 成島尚之

2020/09/17
チタン表面に作製した炭素・窒素含有TiO2膜の可視光照射下における抗菌能

古泉隆祐, 上田隆統志, 上田恭介, 伊藤甲雄, 小笠原康悦, 成島尚之

2020/09/16
MnおよびSiを添加したステント用Co-Cr合金の微細組織と機械的特性

柳原創, 植木洸輔, 上田恭介, 仲井正昭, 中野貴由, 成島尚之

2020/09/17
金属系材料の生体応用に向けた表面および組織創製プロセスの開発 Invited

K. Ueda

2020/09/17
Antibacterial activity of bioresorbable Ag-containing amorphous calcium phosphate films International-presentation

K. Ueda, B. Inoue, N. Kondo, K. Ito, K. Ogasawara, T. Narushima

2017 12th International Workshop on Biomaterials in Interface Science　2017/08/04
Ag含有非晶質リン酸カルシウムコーティングによる硬組織代替デバイスへの抗菌性と骨形成能の付与

井上紅花, 伊藤甲雄, 小笠原康悦, 成島尚之

第37回日本骨形態計測学会　2017/06/22
元素添加非晶質リン酸カルシウム膜の構造と溶解性

永田彪, 小幡亜希子, 春日敏宏, 成島尚之

日本金属学会第160回大会　2017/03/15
Ti-17合金の耐酸化性に及ぼすSi添加の影響

上田恭介, 鈴木聡, 成島尚之

第4回チタン若手交流会　2016/11/04
Improvement of oxidation resistance of Ti-6Al-4V alloy by Si addition International-presentation

T. Narushima

Global/Local Innovations for Next Generation Automobiles in 13th International Conference on Flow Dynamics　2016/10/11
元素添加による生体吸収性非晶質リン酸カルシウム薄膜の生体適合性向上

小幡亜希子, 春日敏宏, 小笠原康悦, 成島尚之

東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北地域講演会「バイオマテリアル研究若手交流会」　2016/09/26
Fabrication of a bioresorbable Ag-containing amorphous calcium phosphate coating film and evaluation of its antibacterial activity International-presentation

K. Ueda, N. Kondo, O. Gokcekaya, T. Kasuga, A. Obata, K. Ogasawara, H. Kanetaka, T. Narushima

The 9th Pacific Rim International Conference on Advanced Materials and Processing (PRICM9)　2016/08/01
Effect of chemical state of silver added to calcium phosphates on dissolution behavior, antibacterial activity, and cytotoxicity International-presentation

K. Ueda, O. Gokcekaya, K. Ogasawara, H. Kanetaka, T. Narushima

International Conference on Processing & Manufacturing of Advanced Materials (THERMEC’ 2016)　2016/05/29
TiへのAg含有非晶質リン酸カルシウム薄膜の作製とその抗菌性評価

上田恭介, 近藤なつ美, O. Gokcekaya, 小幡亜希子, 春日敏宏, 小笠原康悦, 成島尚之

軽金属学会第130回秋季大会　2016/05/28
Fabrication and evaluation of Nb-containing amorphous calcium phosphate coating film on Ti International-presentation

K. Ueda, A. Obata, T. Kasuga, T. Goto, K. Ogasawara, T. Narushima

10th World Biomaterials Congress (WBC2016)　2016/05/17
RFマグネトロンスパッタリング法によるAg含有非晶質リン酸カルシウム薄膜の作製とその評価

上田恭介, 近藤なつ美, 小幡亜希子, 春日敏宏, 小笠原康悦, 成島尚之

日本金属学会第158回大会　2016/03/23
高酸素Ti-V合金の組織と機械的特性

上田恭介, 小林達矢, 成島尚之

第3回チタン若手研究会　2015/12/04
機能性Ti系合金細線の回転曲げ疲労特性に及ぼす非金属介在物の影響

上田恭介, 原健治, 山下史祥, 石川浩司

軽金属学会第129回秋季大会　2015/11/21
アルブミン含有溶液中における生体用Co-Cr-Mo合金の摩耗挙動

上田恭介, 丹野将教, Jean Geringer, 成島尚之

日本金属学会第157回大会　2015/09/16
Evaluation of antibacterial activity of Ag-containing calcium phosphates International-presentation

K. Ueda, O. Gokcekaya, T. Narushima, K. Ogasawara, H. Kanetaka

The 10th Anniversary International Workshop on Biomaterials in Interface Science　2015/08/04
Control of bioresorbability of amorphous calcium phosphate coating film with niobium added International-presentation

K. Ueda, T. Takahashi, A. Obata, T. Kasuga, T. Goto, T. Narushima

Biomaterials International 2015　2015/06/01
Ag含有リン酸カルシウムの抗菌性評価

上田恭介, 関山雅人, Ozkan Gokcekaya, 成島尚之, 小笠原康悦

粉体粉末冶金協会平成27年度春季大会　2015/05/26
高酸素濃度含有α+β型Ti-V合金の組織と機械的特性

上田恭介, 小林達矢, 成島尚之

軽金属学会第128回春季大会　2015/05/16
ドライプロセスによるチタンの骨適合化表面改質

上田恭介, 成島尚之, 後藤孝, 小幡亜希子, 春日敏宏, 小笠原康悦

日本金属学会第156回大会　2015/03/18
Biomaterials: Metallic materials in the human body International-presentation

K. Ueda

13th Tohoku Univ. & Univ. Sci. Technol. Beijing exchange program, USTB　2015/03/06
生体吸収性リン酸カルシウムによるインプラントの骨適合性向上

上田恭介, 成島尚之, 後藤孝, 小幡亜希子, 春日敏宏, 小笠原康悦

日本材料学会第38回生体・医療材料部門委員会　2015/01/20
高酸素濃度含有チタン合金の組織と特性

上田恭介, 小林達矢, 成島尚之

軽金属学会第127回秋季大会　2014/11/15
回転曲げ疲労試験による生体用NiTi細線の疲労特性評価

上田恭介, 原健治, 成島尚之, 山下史祥, 石川浩司

SMAシンポジウム2014　2014/11/13
金属系バイオマテリアルの骨適合化表面処理

上田恭介

(一社)表面技術協会関東支部第88回講演会　2014/10/24
Production of Low-cost and high functionalized titanium by controlling the light elements International-presentation

K. Ueda, T. Narushima

Global/Local Innovations for Next Generation Automobiles, ICFD2014　2014/10/09
生体用Co-Cr-Mo合金融体中における窒素溶解度

上田恭介, 堀野祐司, 成島尚之

日本金属学会第155回大会　2014/09/24
Evaluation of TiO2 layer formed on Ti-Nb alloys by thermal oxidation International-presentation

K. Ueda, Y. Tokuda, S. Sado, T. Narushima

9th International Workshop on Biomaterials in Interface Science　2014/08/26
熱酸化法によりTi上に形成されるTiO2皮膜特性に及ぼすNbの影響

上田恭介, 徳田洋介, 佐渡翔太, 近藤なつ美, 成島尚之

軽金属学会第126回春季大会　2014/05/17
Nb添加非晶質リン酸カルシウム薄膜の生体外評価

上田恭介, 髙橋拓巳, 後藤孝, 小幡亜希子, 春日敏宏, 川野光子, 小笠原康悦, 成島尚之

日本金属学会第154回大会　2014/03/21
Synthesis and evaluation of Ag-containing calcium phosphates International-presentation

K. Ueda, O. Gokcekaya, T. Narushima, C. Eurgun

International Conference on Processing & Manufacturing of Advanced Materials (THERMEC’ 2013)　2013/12/02
溶融金属浸漬法によるNiTiのポーラス表面形成とその応用

上田恭介, 廣橋正博, 橋本龍真, 和田武, 加藤秀実, 成島尚之

SMAシンポジウム2013　2013/11/14
リン酸カルシウムスパッタ膜形成によるチタンの生体機能化

上田恭介, O. Gokcekaya, 成島尚之, 小幡亜希子, 春日敏宏

(一社)日本鉄鋼協会・(公社)日本金属学会関西支部材料開発研究会　2013/10/25
RFマグネトロンスパッタリング法による元素添加リン酸カルシウムコーティング

上田恭介, 小幡亜希子, 春日敏宏, 成島尚之

日本バイオマテリアル学会東北地区講演会　2013/10/07
Synthesis of Ag-containing calcium phosphates using precipitation method International-presentation

K. Ueda, O. Gokcekaya, T. Narushima, C. Ergun

8th International Workshop on Biomaterials in Interface Science　2013/08/29
Dealloying of NiTi by immersion in metallic melt International-presentation

K. Ueda, M. Hirohashi, T. Narushima, T. Wada, H. Kato

The 8th Pacific Rim International Conference on Advanced Materials and Processing (PRICM8)　2013/08/04
チタン中における希土類酸化物の溶解/析出挙動

上田恭介, 神﨑文兵, 成島尚之

軽金属学会第124回春季大会　2013/05/18
溶融金属浸漬法によるNiTiのポーラス化と金属イオン溶出

上田恭介, 橋本龍真, 成島尚之, 和田武, 加藤秀実

日本金属学会第152回大会　2013/03/27
NiTi合金中の非金属介在物

上田恭介, 我妻由貴, 青木翔, 成島尚之, 山下文祥, 石川浩司

SMAシンポジウム2012　2012/11/29
NiTi合金中非金属介在物に及ぼす軽元素および熱処理の影響

上田恭介, 我妻由貴, 青木翔, 成島尚之, 山下史祥, 石川浩司

日本バイオマテリアル学会シンポジウム2012　2012/11/26
溶融金属浸漬法によるNiTiからのNi除去

上田恭介, 廣橋正博, 成島尚之, 和田武, 加藤秀実

日本金属学会第151回大会　2012/09/17
Fabrication of element-doped calcium phosphate coating film by RF magnetron sputtering International-presentation

K. Ueda, T. Takahashi, T. Goto, T. Kasuga, A. Obata, T. Narushima

International Workshop on Biomaterials in Biosis-Abiosis Intelligent Interface Science　2012/08/02
TiB析出を利用した生体用+型チタン合金の結晶粒微細化

上田恭介, 木村泰典, 成島尚之

軽金属学会第122回春季大会　2012/05/19
生体用Co-Cr-Mo合金の摩耗挙動に及ぼす擬似体液の影響

上田恭介, 中家香織, 峯田真悟, 難波茂信, 米田隆志, 石水敬大, 成島尚之

日本金属学会第150回大会　2012/03/28
Si添加Ca-P-Na-Ti-O系スパッタリング膜の生体外評価

上田恭介, 玉手聡一郎, 後藤孝, 小幡亜希子, 春日敏宏, 成島尚之

日本金属学会第149回大会　2011/11/07
RFマグネトロンスパッタリング法によるチタンへのリン酸カルシウムコーティング

上田恭介

日本金属学会第149回大会　2011/11/07
生体吸収性非晶質リン酸カルシウムスパッタ膜の生体内評価

上田恭介, 西脇成彦, 玉手聡一郎, 横田聡, 後藤孝, 川村仁, 成島尚之

粉体粉末冶金協会平成23年度秋季大会　2011/10/26
In vivo evaluation of amorphous calcium phosphate sputtered coating film International-presentation

K. Ueda, N. Nishiwaki, S. Tamate, S. Yokota, T. Goto, H. Kawamura, T. Narushima

The 6th International Workshop on Nano-, Bio- and Amorphous Materials　2011/08/08
Fabrication and evaluation of Ca-P-Na-Ti-O coating film fabricated using RF magnetron sputtering International-presentation

K. Ueda, S. Tamate, T. Goto, A. Obata, T. Kasuga, T. Narushima

12th Conference of the European Ceramics Society　2011/06/19
Fabrication and evaluation of Ca-P-Na-Ti-Si-O coating film fabricated using RF magnetron sputtering International-presentation

K. Ueda, S. Tamate, T. Goto, A. Obata, T. Kasuga, T. Narushima

Baltic Boat Conference 2011 (BBC11)　2011/06/16
チタン基板上に作製された Ca-P-Na-Ti-Si-O 系スパッタリング膜の生体外評価

上田恭介, 玉手聡一郎, 後藤孝, 小幡亜希子, 春日敏宏, 成島尚之

日本金属学会第148回大会　2011/03/25
ドライプロセスを利用したチタンの骨適合化表面処理

日本金属学会・日本鉄鋼協会東海支部第58回若手材料研究会　2011/01/25
Fabrication of Ca-P-Na-Ti-Si-O thin film on titanium by RF magnetron sputtering International-presentation

K. Ueda, S. Tamate, T. Goto, A. Obata, T. Kasuga, T. Narushima

Tohoku-Harvard GCOE Program Research Student Workshop　2011/01/06
Pack cementation treatment of titanium using tetracalcium phosphate powder International-presentation

K. Ueda, K. Nakaie, H. Suto, T. Narushima, M. Taira

Novosibirsk-Tohoku Global COE Conference for young scientists　2010/09/21
In vitro evaluation of pack cementation treated titanium using tetracalcium phosphate powder International-presentation

K. Nakaie, H. Suto, T. Narushima, M. Taira

International Workshop on Nano, Bio and Amorphous Materials　2010/08/09
Pack cementation treatment of titanium using tetracalcium phosphate powder for biomedical applications International-presentation

H. Suto, K. Nakaie, T. Narushima

The 7th Pacific Rim International Conference on Advanced Materials and Processing, PRICM7　2010/08/02
リン酸四カルシウムを用いたパックセメンテーション法により表面処理したチタンの生体外評価

中家香織, 平雅之, 成島尚之

軽金属学会第146回大会　2010/05/22
リン酸四カルシウム粉末を用いたパックセメンテーション法によるチタンの表面改質

須藤初, 中家香織, 成島尚之

日本金属学会第146回大会　2010/03/28
Evaluation of double-layer calcium phosphate coating film fabricated by RF magnetron sputtering on titanium substrate International-presentation

T. Narushima, Y. Kawasaki, T. Goto, J. Kurihara, H. Kawamura

ISPlasma2010　2010/03/07
Bioceramics coating on titanium materials International-presentation

International Cooperation between KITECH and Tohoku University　2010/02/25
リン酸四カルシウム粉末を用いたパックセメンテーション法によるチタンの骨適合化表面改質

須藤初, 中家香織, 成島尚之

粉体粉末冶金協会秋季大会研究発表　2009/10/27
Surface modification by pack cementation using HAp and TTCP powders for biomedical applications International-presentation

H. Suto, T. Narushima

Interdisciplinary Science of Nanomaterials　2009/09/25
チタン基板上に作製したリン酸カルシウムコーティング膜評価

川﨑雄城, 成島尚之, 後藤孝, 栗原淳, 川村仁

日本機械学会2009年次大会　2009/09/13
Evaluation of calcium phosphate coating film fabricated by RF magnetron sputtering on titanium substrate International-presentation

T. Narushima, Y. Kawasaki, T. Goto, J. Kurihara, H. Kawamura

Nano/Amorphous Materials and Interface Science Symposium　2009/08/07
パックセメンテーション法によるチタンの骨適合化表面改質

須藤初, 成島尚之

東北大学金属材料研究所共同研究ワークショップ　2009/07/28
リン酸カルシウムを用いたパックセメンテーション法によるチタンの表面改質

須藤初, 成島尚之

軽金属学会第116回春季大会　2009/05/21
PLD法によるリン酸カルシウムコーティング

戸田智美, 塗溶, 後藤孝, 成島尚之

日本金属学会第144回大会　2009/03/28
Calcium phosphate coating on titanium implants by RF magnetron sputtering International-presentation

T. Narushima, T. Goto, T. Katsube, H. Nakagawa, H. Kawamura, M. Taira

The 1st International Symposium on Advanced Synthesis and Processing Technology for Materials ASPT08　2008/11/14
In vivo and in vitro evaluation of amorphous calcium phosphate coating film fabricated on blast-treated titanium implants by RF magnetron sputtering International-presentation

T. Narushima, T. Goto, J. Kurihara, H. Nakagawa, H. Kawamura, M. Taira

The 6th Korea-China Symposium on Biomaterials and Nano-Bio Technology　2008/10/29
チタン上に作製したリン酸カルシウムコーティング膜の生体内外評価

成島尚之, 後藤孝, 栗原淳, 中川浩伸, 川村仁

日本バイオマテリアル学会東北地域講演会　2008/09/05
Amorphous calcium phosphate coating on blast-treated titanium implants fabricated using RF magnetron sputtering International-presentation

T. Narushima, T. Goto, J. Kurihara, H. Nakagawa, H. Kawamura, T. Taira

The 3rd International Symposium on NANO-BIO and AMORPHOUS MATERIALS　2008/08
RFマグネトロンスパッタリング法によるチタン表面へのリン酸カルシウムコーティング

成島尚之, 後藤孝

表面技術協会「ナノテク部会」第24回研究会（医工学材料・デバイスのための表面処理技術）　2008/05
Evaluation of calcium phosphate films coated on titanium using RF magnetron sputtering

T. Narushima, T. Katsube, H. Nakagawa, H. Kawamura, T. Goto

GlobalCOE Material Integration International Center of Education and Research Reports by Young Researchers　2008/03
In vitro and in vivo evaluation of amorphous calcium phosphate films on titanium using RF magnetron sputtering

T. Narushima, T. Katsube, T. Goto, H. Nakagawa, H. Kawamura, T. Katsube

第18回日本MRS学術シンポジウム　2007/12
Evaluation of amorphous calcium phosphate coating films fabricated on titanium by using RF magnetron sputtering International-presentation

T. Narushima, T. Goto, H. Nakagawa, H. Kawamura, T. Goto

1st Asian Biomaterials Congress　2007/12
Surface reactions of calcium phosphate coating films fabricated using RF magnetron sputtering on blast-treated titanium implants International-presentation

T. Narushima, T. Katsube, H. Kawamura, T. Goto

7th Pacific Rim conference on ceramics and glass technology　2007/11
In vivo and in vitro evaluations of calcium phosphate films coated on titanium by RF magnetron sputtering International-presentation

T. Narushima, T. Goto, H. Nakagawa, H. Kawamura, T. Katsube

The 11th World Conference on Titanium　2007/06
RFマグネトロンスパッタリング法によりチタン上に作製したリン酸カルシウム膜の密着力

成島尚之, 勝部朝之, 川村仁, 後藤孝

日本金属学会第140回大会　2007/03
In Vitro and In vivo Evaluations of Calcium Phosphate Films on Titanium Fabricated using RF Magnetron Sputtering International-presentation

T. Narushima, T. Katsube, M. Taira, H. Kawamura, T. Goto

International Symposium on Interdisciplinary Science of Nanomaterials　2007/01
In Vitro Evaluations of RF Magnetron-Sputtered Calcium Phosphate Films on Titanium International-presentation

T. Narushima, T. Katsube, H. Kawamura, T. Goto

The 3rd International Symposium on Advanced Ceramics　2006/12
RFマグネトロンスパッタリング法によるブラストチタン基板へのリン酸カルシウムコーティング

成島尚之, 勝部朝之, 川村仁, 後藤孝

日本金属学会第139回大会　2006/09
リン酸カルシウムスパッタリング膜の生成相と生体吸収性の関係

成島尚之, 勝部朝之, 中川, 浩伸, 川村仁, 増本博, 後藤孝

第111回東北大学金属材料研究所所内講演会　2006/05
チタン基板上に作製されたリン酸カルシウムスパッタリング膜の生体内外評価

藤田健資, 成島尚之, 後藤孝, 勝部朝之, 中川浩伸, 川村仁, 大内千秋, 井口泰孝

日本金属学会第138回大会　2006/03
RFマグネトロンスパッタリング法によるインプラント用チタン材料へのリン酸カルシウムコーティング

成島尚之, 勝部朝之, 川村仁, 井口泰孝, 増本博, 後藤孝

第110回東北大学金属材料研究所所内講演会　2005/11
RFマグネトロンスパッタリング法により作製したリン酸カルシウム膜の生体内外評価

藤田健資, 成島尚之, 後藤孝, 増本博, 勝部朝之, 川村仁, 大内千秋, 井口泰孝

第44回セラミックス基礎科学討論会　2005/11
RFマグネトロンスパッタリング法によるチタン製人工歯根へのリン酸カルシウムコーティング

藤田健資, 成島尚之, 後藤孝, 増本博, 勝部朝之, 川村仁, 大内千秋, 井口泰孝

日本セラミックス協会東北北海道支部研究発表会　2005/10
Preferred orientation of calcium phosphate films prepared by RF magnetron sputtering International-presentation

T. Narushima, T. Goto, T. Katsube, H. Kawamura, C. Ouchi, Y. Iguchi

Asian BioCeramics Symposium　2005/10
RFマグネトロンスパッタリング法によるリン酸カルシウムスパッタリング膜の配向性

藤田健資, 成島尚之, 後藤孝, 増本博, 勝部朝之, 川村仁, 大内千秋, 井口泰孝

日本金属学会第137回大会　2005/09
RFマグネトロンスパッタリング法によるインプラント用チタン材料表面へのリン酸カルシウムコーティング

成島尚之, 後藤孝, 増本博, 勝部朝之, 川村仁, 大内千秋, 井口泰孝

日本金属学会第136回大会　2005/03
インプラント用チタン表面上へのリン酸カルシウムコーティング膜の作製と評価

成島尚之, 後藤孝, 増本博, 勝部朝之, 川村仁, 大内千秋, 井口泰孝

日本金属学会東北支部研究発表大会　2005/02
Wear loss and elution of C.P.Ti and titanium alloys in simulated body fluids International-presentation

T. Narushima, C. Ouchi, Y. Iguchi

5th Pacific Rim International Conference on Advanced Materials and Processing　2004/11
回転曲げ法によるチタンの疲労特性

山下満好, 村上太一, 成島尚之, 大内千秋, 井口泰孝

日本金属学会第135回大会　2004/09
ピンオンディスク法によるチタンおよびチタン合金の比摩耗量とイオン溶出

木村元彦, 成島尚之, 大内千秋, 井口泰孝

日本金属学会第134回大会　2004/03
擬似体液中におけるステンレス鋼およびチタン合金の界面反応

成島尚之, 大内千秋, 井口泰孝

日本金属学会第133回大会　2003/09

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Industrial Property Rights 6

NiTi系合金材料、NiTi系合金の製造方法、NiTi系合金材料からなる線材または管材、およびその製造方法

山下史祥, 石川浩司, 喜瀬純男, 藤井美里, 成島尚之, 上田恭介, 加藤卓

Property Type: Patent
チタン素材の脱酸方法

松若大介, 成島尚之, 上田恭介

Property Type: Patent
光触媒機能性部材およびその製造方法

成島尚之, 上田恭介, 上田隆統志, 佐渡翔太, 小笠原康悦, 伊藤甲雄, 金高弘恭

Property Type: Patent
耐熱Ti合金および耐熱Ti合金材

成島尚之, 上田恭介, 前田幸大, 鈴木聡

Property Type: Patent
Ti−Si系合金の脱酸方法

松若大介, 成島尚之, 上田恭介, 渡辺将仁

Property Type: Patent
NiTi系超弾性合金材料または形状記憶合金材料及びこれを用いた線材または管材

成島尚之, 上田恭介, 原健治, 山下史祥, 石川浩司

Property Type: Patent

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Research Projects 27

析出物を利用したチタンの結晶粒微細化 Competitive

System: The Other Research Programs

2011/04 - Present
Development of next generation ultrahigh corrosion resistant and functional stainless steel by combination of novel surface treatment and laser processing

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: National Institute for Materials Science

2024/04/01 - 2029/03/31
Development of photo-functional antibacterial and antiviral material surfaces considering bacterial adhesion and virus adsorption

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2025/04/01 - 2028/03/31
Development of antibacterial-expressing self-maintenance implant surfaces using biological window

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2024/04/01 - 2028/03/31
ノンパラメータ階層計算技術による耐熱材料設計

佐原亮二, 成島尚之, 大野かおる, 上田恭介

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 国立研究開発法人物質・材料研究機構

2024/04/01 - 2027/03/31
Innovation of titanium smelting and refining process using hydrogen plasma

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Pioneering)

Institution: Tohoku University

2022/06/30 - 2025/03/31
Materials surface design to inactivate coronaviruses by focusing on spike proteins

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2021/04/05 - 2025/03/31
Development of Novel Tailor-Made CoCr-Based Superelastic Biomaterials

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Institution: Tohoku University

2020/10/27 - 2025/03/31
Theoretical investigation of surface chemical reaction in high temperature materials

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: National Institute for Materials Science

2021/04/01 - 2024/03/31
Functionalization of implant by bio-active coating with ion release and high bonding strength

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2020/04/01 - 2024/03/31
超高純度Mgの生体内溶解速度と強度制御技術確立による新規Mg合金製インプラント材料の開発

上田恭介

Offer Organization: 科学技術振興機構

System: 産学が連携した研究開発成果の展開研究成果展開事業研究成果最適展開支援プログラム(A-STEP) 産学共同(育成型)

Institution: 東北大学

2022 - 2024

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顎顔面や脳外科領域での骨折治療時に使用するインプラント(骨プレート)において、従来のチタン合金は溶解しないため、骨接合後に摘出手術が必要である。本課題では、骨接合後に生体内で溶解することで摘出手術が不要となり、低侵襲治療が期待される、亜鉛のみを少量含む超高純度マグネシウム材料を開発する。不均一溶解の原因となる不純物元素を含まない本材料の生体内での強度・溶解性の制御技術確立により、インプラント使用部位に応じた最適な強度、溶解性を持つ材料を提供する。具体的には、1.材料の強度と溶解性を自在に制御できる製造技術、2.動物実験に代わるオフライン溶解性評価技術、3.材料の強度・溶解性マップの提示を行う。
Creation of optically-functional titanium surface with compatibility of bone forming ability and antibacterial activity and its application to implants

Narushima Takayuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2018/04/01 - 2022/03/31

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We succeeded in fabricating a Ti surface with both osteogenic and antibacterial properties for application to dental implants. The Au-containing TiO2 layers prepared on the Ti surface by an original process based on Au-sputtering and thermal oxidation showed antibacterial activity against E. coli under visible-light irradiation. The photofunction of the Au-containing TiO2 layers obtained in this study is considered to be an achievement to realize the “self-maintenance function” in which the implant itself plays a role in “healing” by reattaching to bone tissue and also enables “prevention” by patients themselves. These results, together with the excellent adhesion between the TiO2 layers and the Ti substrates, are expected to be applied not only to dental implants but also to the prevention of contact infection of the new coronavirus (SARS-CoV-2).
極微量希土類元素添加による介在物制御に基づくNiTi製ステントの超長寿命化

上田恭介

Offer Organization: 科学技術振興機構

System: 産学が連携した研究開発成果の展開研究成果展開事業研究成果最適展開支援プログラム(A-STEP) トライアウトトライアウト

Institution: 東北大学

2020 - 2021

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ステント用NiTiの超長寿命化を目指し、極微量希土類元素添加による介在物制御に基づいた疲労強度向上技術を開発する。NiTiには酸化物型および炭化物型介在物が存在するが、2μm以上の大きな酸化物型介在物がNiTi細線破断時の亀裂の起点となることを見出した。NiTi中での希土類酸化物形成による脱酸反応を利用し、耐食性は維持しつつ、1000倍視野当たり50個程度存在する酸化物型介在物を10個以下に低減させる。本NiTiを用いた細線作製プロセスを確立し、回転曲げ疲労試験により疲労強度を評価する。本技術によるNiTiの超長寿命化は、現在NiTiが使用されているステントやアクチュエータの小型化に貢献する。
Removal of oxygen from titanium melt using hydrogen plasma arc: Challenge to 300 ppm

Narushima Takayuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Challenging Research (Exploratory)

Category: Challenging Research (Exploratory)

Institution: Tohoku University

2018/06/29 - 2020/03/31

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The oxygen removal process from titanium melt, which was considered difficult in the past, has been established. The process consists of hydrogen plasma arc melting (first-step melting) and argon plasma arc melting (second-step melting). Oxygen removal from 0.127 mass% (1270 mass ppm) to 0.034 mass% (340 mass ppm) was achieved in the titanium melt by optimizing in melting conditions such as hydrogen partial pressure, melting time, gas flow rate and plasma current. Thermodynamic consideration suggested that the dissolved hydrogen introduced into titanium melt in response to the high hydrogen potential of active atomic hydrogen in plasma functions as a deoxidizer in the second-step melting. An international patent application was filed based on the results of this research.
Release Release of bone morphogenetic protein using amorphous calcium phosphate film as a carrier

UEDA KYOSUKE

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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The surface treatment process for both improving the bone compatibility and achieving antibacterial property on Ti implants was established by focusing on the dissolution of amorphous calcium phosphate (ACP). Bone morphogenetic protein (BMP) was loaded on the surface of the ACP coating films fabricated by RF magnetron sputtering. Sustained release of BMP through the dissolution of ACP coating film was observed. Ag- and Ta- co-added ACP coating film was fabricated by controlling the composition of the target during the sputtering process. The dissolution of Ag-added ACP coating films in simulated body fluids was suppressed by the addition of Ta in the coating film. It was estimated that the long-term antibacterial activity and improving the bone formation of the Ti implants by the release of Ag ion and ACP coating films, respectively.
非晶質リン酸カルシウム薄膜を担体とした骨形成タンパク質の徐放性評価 Competitive

上田恭介

System: 科学研究費補助金基盤研究(C)

2017/04 - 2020/03
Fabrication of drug-release type implant using amorphous calcium phosphate film as a carrier Competitive

Ueda Kyosuke, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2015/04/01 - 2017/03/31

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Bone morphogenetic protein (BMP) was loaded on amorphous calcium phosphate (ACP) film by immersion in BMP-2 solution. The releasing behavior of BMP-2 from ACP film was evaluated. The amount of BMP-2 loaded on ACP film by immersion in PBS(-) without heparin was higher than that with heparin. The BMP-2 loaded on ACP film by immersion in PBS(-) without heparin was released continuously for 12 h.
Creation of implants to influence human body using bioresorbable amorphous calcium phosphate films Competitive

Ueda Kyosuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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Amorphous calcium phosphate (ACP) film known as bioresorbable material was focused on the surface modification of bone substitutes to improve the bone compatibility. Controlling the bioresorbability and giving the antibacterial activity to the ACP film were conducted by addition of elements and Ag, respectively. Nb and Ta addition to ACP film suppressed the bioresorbability of ACP film. Ag added ACP film showed antibacterial activity against E. coli and S. aureus.
Biofunctionalization of metallic biomaterials by forming ceramic interface layers

NARUSHIMA Takayuki, KASUGA Toshihiro, OGASAWARA Kouetsu, UEDA Kyosuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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Ceramic coating layers of amorphous calcium phosphate (ACP) and TiO2 were prepared on Ti, and their antibacterial activities were evaluated. Ag-containing ACP layers fabricated by RF magnetron sputtering exhibited antibacterial activity through the continuous release of Ag ions, caused by the resorbability of ACP. TiO2 layers fabricated by thermal oxidation processes showed photodegradation of organic compounds and antibacterial activity under both UV- and visible-light irradiation. The introduction of Au into TiO2 layers from Ti-Au alloy substrates contributed to the expression of visible-light response. The optimized fabrication processes provided the coating films with both the bone forming ability and antibacterial activity.
Formation of porous surface on NiTi and suppression of Ni ion release Competitive

UEDA Kyosuke, NARUSHIMA Takayuki, KATO Hidemi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2012/04/01 - 2014/03/31

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A dealloying Ni surface having a porous structure was prepared from NiTi alloys through immersion in molten metals. The concentration of Ni from the NiTi substrate to the surface was decreased in a stepwise manner forming an inner Ti2Ni layer and outer alpha-Ti layer on the substrate. The amounts of metallic ions eluted from these specimens to 1mass% lactic acid solution were evaluated. Despite the increased surface area of the dealloyed specimen, Ni ion elution was suppressed to the same level as that in the non-treated NiTi substrate. The anatase layer formed by two-step thermal oxidation suppressed the Ni ion release from the dealloyed substrate.
Development of bone-compatible interface using bioresorbable calcium phosphate coating film

NARUSHIMA Takayuki, UEDA Kyosuke, KAWAMURA Hiroshi, KASUGA Toshihiro, TAIRA Masayuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2010 - 2012

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In vivo and in vitro evaluations of an amorphous calcium phosphate film formed on commercially pure titanium were conducted. Titanium implants coated with amorphous calcium phosphate were given to the femur and tibia of white rabbits. The implant stability quotient (ISQ) and bone implant contact for titanium implants were statistically improved by the coating of amorphous calcium phosphate. The coating film was absorbed during an implantation period of two-weeks; the release of Ca and P-related ions due to this absorption was suggested to play an important role in the improvement of bone compatibility. Further, the addition of Nb to the amorphous calcium phosphate film was an effective technique to control its resorbability in biological environments.
骨形成能向上を目的としたパックセメンテーション法によるチタン系材料の表面改質 Competitive

Kyosuke Ueda

System: Grant-in-Aid for Scientific Research

2009/04 - 2011/03
Surface modification of titanium by pack cementation process for improvement of bone compatibility

UEDA Kyosuke, NARUSHIMA Takayuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2009 - 2010

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Calcium phosphate reaction layers were fabricated on titanium by pack cementation process, isobaric-isothermal process and their combination process to improve the bonecompatibility of titanium. The phase of the reaction layer was hydroxyapatite (HAp) and Ca-P-O-Ti graded layer, and its thickness was several μm. The reaction layer showed high bonding strength to the substrate and high ALP activity by the cell culture test. These results suggested that the new process effectively improved the bone compatibility of titanium.
多機能型プラチナ基材料の開発と応用 Competitive

System: JST Comprehensive Support Programs for Creation of Regional Innovation

2008/04 - 2009/03
Ceramic surface modification of titanium for controlling bone-forming ability

NARUSHIMA Takayuki, UEDA Kyosuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2007 - 2009

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The formation and evaluation of bio-ceramic layer for improving bone-forming ability of titanium have been investigated, and the following results were obtained. (1) The bioresorbable amorphous calcium phosphate coating fabricated using RF magnetron sputtering improved the bone-compatibility of titanium implants. (2) The anatase-rich film with high bone-forming ability was fabricated on titanium by the newly developed two-step thermal oxidation process with low-cost and simplicity.
生体内吸収性セラミックスとチタン系材料を利用した生体機能再建デバイスの開発 Competitive

Kyosuke Ueda

System: GAKUSHIN DC1

2005/04 - 2008/03
生体内吸収性セラミックスとチタン系材料を利用した生体機能再建デバイスの開発

上田恭介

Offer Organization: 日本学術振興会

System: 科学研究費助成事業特別研究員奨励費

Category: 特別研究員奨励費

Institution: 東北大学

2005 - 2007

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【研究目的および方法】歯科分野における生体機能再建をめざし、優れた生体適合性を有するチタン系材料と生体活性/吸収性リン酸カルシウム系材料を複合化したデバイスの開発を目的として、これまでRFマグネトロンスパッタリング法によりチタン基板へのリン酸カルシウムコーティングを行ってきた。これまでの成果から、非晶質リン酸カルシウムコーティング膜において高い骨適合性を、結晶質リン酸カルシウムコーティング膜において擬似体液浸漬後でも高い密着力を示すことを明らかにしてきた。そこで今年度はコーティング膜の多層化に着目し、基板/コーティング膜界面には結晶質リン酸カルシウム、コーティング膜/生体界面には非晶質リン酸カルシウムコーティング膜を作製し、これらの評価を行った。プロセスの途中で条件を変化させることで多層膜を作製した。生体外評価として基板とコーティング膜との密着力評価を、生体内評価として多層膜をブラスト処理した人工歯根にコーティングし、それらをウサギの大腿骨に埋入した。2,4週埋入後に人工歯根を取り出す際のトルク(回転除去トルク)を測定することで、コーティング膜の骨適合性を評価した。【研究成果】ブラスト処理Ti-6A1-4V製基板上に、基板側に結晶質(OAp)膜を、外側に非晶質(ACP)膜をそれぞれ作製した2層コーティング膜を作製することができた。このコーティング膜の基板との密着力は、OAp単層の場合と同程度であり、十分な強度を得ることができた。また、動物埋入試験の結果から、回転除去トルクはいずれの週齢においてもコーティングを施さなかった試料(コントロール)およびACPもしくはOAp単層をコーティングした試料よりも高い値を示し、特に埋入2週目においてはコントロールよりも有意に高い値であった。

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Teaching Experience 6

生体材料学　東北大学
准教授セミナー　東北大学
数学物理学演習I　東北大学
工業数学II　東北大学
数学物理学演習II　東北大学
学生実験　東北大学

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Social Activities 6

模擬授業

2016/11/17 -

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群馬県立高崎女子高校での講演
模擬授業

2016/10/27 -

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静岡県立富士高校での講演
若手教員による公開ゼミ

2015/07/30 -

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東北大学工学部材料科学総合学科オープンキャンパス2015 「からだの中で活躍する金属材料」
ものづくりの人材育成支援

2009/08/05 -

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岩手県立大東高等学校において出前授業を行った
高校生が最先端技術を学ぶ

2009/08/04 -

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岩手県立大東高等学校において出前授業を行った。
出前講座（東北産業活性化センターユニバーサイエンス）

2009/08/04 -

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岩手県立大東高等学校において理系学生を対象とした講義を行ったタイトル「からだの中で活躍する材料～金属とセラミックスの融合～」

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Media Coverage 2

体の中で働く人工の部品って？

Chunichi

2018/12/29

Type: Newspaper, magazine
育児期の男性研究者座談会「青葉山のイクメンたち」

宮城の新聞

2014/12/26

Type: Newspaper, magazine

Other 14

可視光照射により抗菌性と骨形成を発現するセルフメンテナンス可能なチタン系インプラント表面処理方法の開発

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可視光照射により抗菌性と骨形成を発現するセルフメンテナンス可能なチタン系インプラント表面処理方法の開発
抗菌性と骨適合性を有するハイブリッドインプラントの創製

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抗菌性と骨適合性を有するハイブリッドインプラントの創製
抗菌性付与を目的としたAg添加リン酸カルシウムコーティング膜の創製とその評価

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RFマグネトロンスパッタリング法によりチタン基板上にAg含有非晶質リン酸カルシウム薄膜を作製し、その抗菌性を評価した。
チタン中における希土類酸化物の溶解/析出挙動

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チタンの結晶粒微細化方法として、希土類元素(RE)添加により生成する希土類酸化物によるピンニングが知られている。しかし、チタン中における希土類酸化物の溶解/析出挙動は不明であり、特に希土類酸化物の溶解度積といった熱力学的データはほとんどない。一方、鉄鋼材料では電解抽出法を用いることで、炭化物や窒化物の直接観察による溶解/析出挙動解析、溶解度積の算出が行われている。本研究では、添加希土類元素としてY, Er, Ceに着目し、Ti-RE2元系合金中希土類酸化物の電解抽出方法の確立、温度域での希土類酸化物の溶解/析出挙動の解明およびそれらの溶解度積の算出を目的とする。
チタン中における希土類酸化物の溶解/析出挙動

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チタン中に存在する微細析出物の観察方法を電解抽出法を用いて確立する。
チタン中における希土類酸化物の溶解/析出挙動

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チタンの結晶粒微細化を目的として、希土類元素であるLa, Y, Ce, Erに着目し、これらの元素を極微量添加したα+β型チタン合金を作製する。添加希土類元素はチタン中に固溶している酸素と反応し、希土類酸化物を形成し、これらがピンとなり、結晶粒が微細化されると予想される。熱処理に伴う希土類酸化物のチタン中の溶解/再析出挙動の把握を行う。
細胞内への金属取り込み経路の同定

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金属アレルギー発症の原因解明を目的とし、細胞への金属イオンの取り込まれ方を調査した
希土類酸化析出物を利用したチタンの結晶粒微細化

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チタンの結晶粒微細化を目的として、希土類元素であるLa, Y, Ce, Erに着目し、これらの元素を極微量添加したα+β型チタン合金を作製する。添加希土類元素はチタン中に固溶している酸素と反応し、希土類酸化物を形成し、これらがピンとなり、結晶粒が微細化されると予想される。熱処理に伴う希土類酸化物のチタン中の溶解/再析出挙動の把握を行う。
チタン中in situ析出物の観察方法確立

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チタン中に存在する微細析出物の観察方法を電解抽出法を用いて確立する。
希土類酸化析出物を利用したチタンの結晶粒微細化

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生体用金属材料であるチタンの熱処理中結晶粒微細化を目的として、Y, La, Ce等の希土類を微量添加し、これらの酸化物を生成させることでピン止め効果を狙う。
有毒元素を含むチタン合金の無毒ナノポーラス表面化技術の確立とその生体材料への応用

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現在NiTi合金は優れた機械的特性から生体埋入材料として利用されているが、Niの毒性が懸念されている。デアロイングを利用した材料表面からの脱Ni処理および表面改質により毒性元素溶出の低減および骨適合性向上を目指す
RFマグネトロンスパッタリング法によるシリコン徐放型リン酸カルシウムコーティング膜の作製とその評価

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RFマグネトロンスパッタリング法によりチタン基板上にシリコン含有リン酸カルシウムコーティング膜の作製を行い、そのシリコン徐放性を擬似体液浸漬試験により評価する。
RFマグネトロンスパッタリング法によるチタンインプラント上へのリン酸カルシウムコーティング

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RFマグネトロンスパッタリング法により作製したリン酸カルシウムコーティング膜の生体内外評価について発表
骨形成能向上を目的としたパックセメンテーション法によるチタンの表面改質

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チタンのリン酸カルシウム系材料での表面改質を目的として、パックセメンテーション法を用いた。

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