TOHOKU UNIVERSITY Researchers

Details of the Researcher

Home

日本語 English

Taro Kanno

Section

Graduate School of Dentistry

Job title

Professor

Degree

博士（歯学）（東北大学）

researchmap

https://researchmap.jp/TaroKanno

J-GLOBAL ID

200901020706982077

Research History 7

2017 - Present

Tohoku University Graduate School of Dentistry　Department of Advanced Free Radical Science　Professor
2015 - 2017

Tohoku University Graduate School of Dentistry, Department of Dentistry, Restorative Dentistry,Molecular and Regenerative Prosthodontics　Assistant Professor
2005 - 2015

Tohoku University　Graduate School of Dentistry
2004 - 2005

スウェーデン・イエテボリ大学・補綴科客員研究員
2004 - 2005

Department of Prosthetic Dentistry / Dental Material Science, Faculty of Odontology, Göteborg University, Göteborg, Sweden.
1998 - 2004

Tohoku University　Faculty of Dentistry
1993 - 1994

Tohoku University　Faculty of Dentistry

Show all Show first 5

Education 4

Tohoku University

- 1998
Tohoku University　Graduate School, Division of Dental Research

- 1998
Tohoku University　Faculty of Dentistry

- 1993
Tohoku University　Faculty of Dentistry

- 1993

Research Areas 1

Life sciences / Prosthodontics /

Papers 88

Critical evaluations on the crystallographic properties of translucent dental zirconia ceramics stabilized with 3-6 mol% yttria

Keisuke Nakamura, Shunichi Shishido, Ryoichi Inagaki, Taro Kanno, Sargon Barkarmo, Per Svanborg, Ulf Örtengren

Dental Materials　2024/06
Publisher: Elsevier BV
DOI： 10.1016/j.dental.2024.06.027 　

ISSN： 0109-5641
Mechanism underlying ultraviolet-irradiation-induced discoloration of dental zirconia ceramics stabilized with 3 and 5 mol% yttria

Akari Kurihara, Keisuke Nakamura, Shunichi Shishido, Ryoichi Inagaki, Akio Harada, Taro Kanno, Hiroshi Egusa

Ceramics International　50　(7)　12136-12145　2024/04
Publisher: Elsevier BV
DOI： 10.1016/j.ceramint.2024.01.117 　

ISSN： 0272-8842
Residual stress associated with crystalline phase transformation of 3-6 mol% yttria-stabilized zirconia ceramics induced by mechanical surface treatments. International-journal

Shunichi Shishido, Ryoichi Inagaki, Taro Kanno, Per Svanborg, Sargon Barkarmo, Ulf Örtengren, Keisuke Nakamura

Journal of the mechanical behavior of biomedical materials　146　106067-106067　2023/08/04

DOI： 10.1016/j.jmbbm.2023.106067 　

More details Close

Monolithic dental prostheses made of 3-6 mol% yttria-stabilized zirconia (3-6YSZ) have gained popularity owing to their improved material properties and semi-automated fabrication processes. In this study, we aimed to evaluate the influence of mechanical surface treatments, such as polishing, grinding, and sandblasting, on the residual stress of 3-6YSZ used for monolithic prostheses in association with crystalline phase transformation. Plate specimens were prepared from five dental zirconia blocks: Aadva Zirconia ST (3YSZ), Aadva Zirconia NT (6YSZ), Katana HT (4YSZ), Katana STML (5YSZ), and Katana UTML (6YSZ). The specimens were either polished using 1, 3, or 9 μm diamond suspensions, ground using 15, 35, or 55 μm diamond discs, or sandblasted at 0.2, 0.3, or 0.4 MPa. The residual stress, crystalline phase, and hardness were analyzed using the cosα method, X-ray diffraction (XRD), and Vickers hardness test, respectively. Additionally, we analyzed the residual stress on the surfaces of monolithic zirconia crowns (MZCs) made of 4YSZ, 5YSZ, and 6YSZ, which were processed using clinically relevant procedures, including manual grinding, followed by polishing using a dental electric motor on the external surface, and sandblasting on the internal surface. Residual stress analysis demonstrated that grinding and sandblasting, particularly the latter, resulted in the generation of compressive residual stress on the surfaces of the plate specimens. XRD revealed that the ground and sandblasted specimens contained a larger amount of the rhombohedral phase than that of the polished specimens, which may be a cause of the residual stress. Sandblasting significantly increased the Vickers hardness compared to polishing, which may possibly be due to the generation of compressive residual stress. In the case of MZCs, compressive residual stress was detected not only on the sandblasted surface, but also on the polished surface. The difference in the residual stress between the plate and crown specimens may be related to the force applied during the automated and manual grinding and polishing procedures. Further studies are required to elucidate the effects of the compressive residual stress on the clinical performance of MZCs.
Mutagenicity assessment of high-power 1.6-THz pulse laser radiation. International-journal

Midori Shirato, Yuma Takida, Taro Kanno, Hiroshi Matsuura, Yoshimi Niwano, Hiroaki Minamide, Keisuke Nakamura

Photochemistry and photobiology　2023/07/21

DOI： 10.1111/php.13840 　

More details Close

The effect of terahertz (THz) radiation has been studied in medicine. However, there is a lack of scientific information regarding its possible mutagenicity. Therefore, the present study aimed to assess the mutagenicity of 1.6 THz laser irradiation. The Ames test was conducted using five bacterial tester strains. The bacteria were subjected to (i) 1.6 THz laser irradiation at 3.8 mW/cm2 for 60 min using a tabletop THz pulse laser system, (ii) ultraviolet irradiation, (iii) treatment with positive control chemicals (positive control) or (iv) treatment with the solvent used in the positive control (negative control). After treatment, the bacterial suspensions were cultured on minimal glucose agar to determine the number of revertant colonies. In addition, the comet assay was performed using fibroblasts (V79) to assess possible DNA damage caused by the THz laser irradiation. The Ames test demonstrated that the THz laser irradiation did not increase the number of revertant colonies compared to that in the negative control group, whereas the ultraviolet irradiation and positive control treatment increased the number of revertant colonies. Thus, 1.6 THz laser irradiation is unlikely to be mutagenic. The comet assay additionally suggests that the THz laser irradiation unlikely induce cellular DNA damage.
Inhibition of tooth demineralization caused by Streptococcus mutans biofilm via antimicrobial treatment using hydrogen peroxide photolysis. International-journal Peer-reviewed

Midori Shirato, Keisuke Nakamura, Taichi Tenkumo, Yoshimi Niwano, Taro Kanno, Keiichi Sasaki, Peter Lingström, Ulf Örtengren

Clinical oral investigations　27　(2)　739-750　2022/12/09

DOI： 10.1007/s00784-022-04821-2 　

More details Close

OBJECTIVES: An antimicrobial technique utilizing hydroxyl radicals generated by the photolysis of 3% H2O2 has been developed recently. The present study aimed to evaluate the effect of H2O2 photolysis treatment on tooth demineralization caused by Streptococcus mutans biofilm. MATERIALS AND METHODS: To induce tooth demineralization, S. mutans biofilm was allowed to form on the maxillary first molars collected from Wistar rats via 24-h culturing. The samples were immersed in 3% H2O2 and irradiated with 365-nm LED (H2O2 photolysis treatment). Viable bacterial counts in the biofilm were evaluated immediately after treatment and after an additional 30-h culturing by colony counting. The acidogenicity of the biofilm, re-established 30 h after treatment, was assessed by measuring the pH. The effect of H2O2 photolysis treatment on tooth demineralization was assessed by measuring the depth of the radiolucent layer in micro-CT images. RESULTS: H2O2 photolysis significantly reduced viable bacterial counts in the biofilm to 3.7 log colony forming units (CFU)/sample, while the untreated group had 7.9 log CFU/sample. The pH of the biofilm re-established after treatment (6.6) was higher than that of the untreated group (5.3). In line with the pH measurement, the treatment group had a significantly lower depth of radiolucent layer in dentin than the untreated group. CONCLUSIONS: H2O2 photolysis treatment was effective not only in killing the biofilm-forming S. mutans but also in lowering the acidogenicity of the biofilm. Thus, this technique could inhibit tooth demineralization. CLINICAL RELEVANCE: H2O2 photolysis can be applicable as a new dental caries treatment.
研磨、研削、サンドブラスト処理がジルコニアの結晶構造および残留応力に及ぼす影響

宍戸駿一, 稲垣亮一, 菅野太郎

日本補綴歯科学会誌　14　(特別号)　192-192　2022/07
Publisher: (公社)日本補綴歯科学会
ISSN： 1883-4426

eISSN： 1883-6860
Impact of adhesive primer and light-curing on polymerization kinetics of self-adhesive resin cement in association with free radical reaction. International-journal

Akane Ozaki, Shunichi Shishido, Keisuke Nakamura, Akio Harada, Yusuke Katsuda, Taro Kanno, Hiroshi Egusa

European journal of oral sciences　2021/10/21

DOI： 10.1111/eos.12828 　

More details Close

This study analyzed the impact of adhesive primer and light-curing on the polymerization kinetics of urethane dimethacrylate-based self-adhesive resin cement combined with free radical reaction. Specimens were prepared by mixing the cement paste with or without adhesive primer. Subsequently, specimens were light-cured or set without light-curing. The degree of conversion (DC), Vickers hardness (Hv), and free radical concentrations were repeatedly measured up to 168 h after the curing initiation. Irrespective of the curing procedures, DC, Hv, and free radical concentration rapidly increased during the initial 30 min of curing. The specimens cured with adhesive primer and/or light-curing generally showed higher values of DC, Hv, and radical concentration than those set by chemical curing alone, especially during the initial polymerization phase. Kinetic analysis using a linear mixed model revealed that the adhesive primer had a higher coefficient estimate than light-curing, indicating that the former had a higher impact on the polymerization. Additionally, the adhesive primer alleviated the Hv reduction caused by water and air during the initial polymerization phase, although light-curing hardly prevented the polymerization inhibition. Therefore, we suggest that application of adhesive primer is beneficial to achieve higher degree of conversion and better mechanical properties of self-adhesive resin cements by enhancing free radical reactions.
Bactericidal activity and recovery effect of hydroxyl radicals generated by ultraviolet irradiation and silver ion application on an infected titanium surface Peer-reviewed

Taichi Tenkumo, Kirika Ishiyama, Oleg Prymak, Keisuke Nakamura, Midori Shirato, Toru Ogawa, Makiko Miyashita, Masatoshi Takahashi, Matthias Epple, Taro Kanno, Keiichi Sasaki

Scientific Reports　10　(1)　2020/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-020-65411-4 　

eISSN： 2045-2322

More details Close

<title>Abstract</title>This study investigated the bactericidal effect, the underlying mechanisms of treatment, and recovery of biocompatibility of the infected titanium surface using a combination treatment of silver ion application and ultraviolet-A (UV-A) light irradiation. <italic>Streptococcus mutans</italic> and <italic>Aggregatibacter actinomycetemcomitans</italic> were used in suspension and as a biofilm on a titanium surface to test for the bactericidal effect. The bactericidal effect of the combination treatment was significantly higher than that of silver ion application or UV-A light irradiation alone. The bactericidal effect of the combination treatment was attributable to hydroxyl radicals, which generated from the bacterial cell wall and whose yield increased with the silver concentration. To assess the biocompatibility, proliferation and calcification of MC3T3E1 cells were evaluated on the treated titanium surface. The treated titanium screws were implanted into rat tibias and the removal torques were measured 28 days post-surgery. The titanium surface that underwent the combination treatment exhibited recovery of biocompatibility by allowing cellular proliferation or calcification at levels observed in the non-infected titanium surfaces. The removal torque 28 days after surgery was also comparable to the control values. This approach is a novel treatment option for peri-implantitis.
Proanthocyanidin-rich grape seed extract improves bone loss, bone healing, and implant osseointegration in ovariectomized animals Peer-reviewed

Taichi Tenkumo, Alkebaier Aobulikasimu, Yoshinori Asou, Midori Shirato, Shunichi Shishido, Taro Kanno, Yoshimi Niwano, Keiichi Sasaki, Keisuke Nakamura

Scientific Reports　10　(1)　2020/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-020-65403-4 　

eISSN： 2045-2322
Reactions of dental pulp to hydrogen peroxide photolysis-based antimicrobial chemotherapy under ultraviolet-A irradiation in rats International-journal Peer-reviewed

Keisuke Nakamura, Midori Shirato, Shunichi Shishido, Yoshimi Niwano, Taro Kanno, Keiichi Sasaki, Peter Lingström, Ulf Örtengren

Journal of Photochemistry and Photobiology B: Biology　212　112042-112042　2020/11
Publisher: Elsevier BV
DOI： 10.1016/j.jphotobiol.2020.112042 　

ISSN： 1011-1344

More details Close

Hydrogen peroxide photolysis-based antimicrobial chemotherapy that utilizes ultraviolet-A irradiation (UVA-H2O2 photolysis) has been previously proposed as a method of treatment of cariogenic biofilm. Therefore, in the present study, we aimed to assess time-dependent reactions in the dental pulp of rats after UVA-H2O2 photolysis. Maxillary first molars were treated. UVA irradiation (wavelength: 365 nm) with 3 wt% H2O2 was performed for 90 s at a radiant emittance of 500-2000 mW/cm2 on the rats for 3 consecutive days or only 1 day. The animals were sacrificed at Days 1, 3, 7, and 21 after the treatment for the histological evaluation of inflammatory cells and immunohistochemistry of heat shock protein (HSP)-25, a marker of odontoblasts. Tertiary dentin formation was evaluated at Day 21 by histomorphometry and micro-CT analysis. UVA-H2O2 photolysis elicited little infiltration of inflammatory cells, but disturbances in the odontoblast layer and/or presence of localized degenerative tissue were observed on Day 3. This condition was followed by a healing process that was characterized by the reappearance of HSP-25 positive odontoblast-like cells at Day 7 and tertiary dentin formation at Day 21. The amount of tertiary dentin formed was dependent on the intensity of treatment; repeated UVA irradiations of H2O2 at 2000 mW/cm2 resulted in the largest amount of tertiary dentin formation at the pulp horn regions. Our findings suggest that UVA-H2O2 photolysis treatment can be used to treat dental caries clinically because the post-treatment inflammatory reaction was minimal and tertiary dentin formation was substantial, which may prove effective in protecting dental pulp from external irritants. As a cautionary consideration, the radiant emittance of the UVA irradiation should be carefully optimized before clinical application.
Mechanical and microstructural properties of ultra-translucent dental zirconia ceramic stabilized with 5 mol% yttria Peer-reviewed

Akio Harada, Shunichi Shishido, Sargon Barkarmo, Ryoichi Inagaki, Taro Kanno, Ulf Örtengren, Hiroshi Egusa, Keisuke Nakamura

Journal of the Mechanical Behavior of Biomedical Materials　111　103974-103974　2020/11
Publisher: Elsevier BV
DOI： 10.1016/j.jmbbm.2020.103974 　

ISSN： 1751-6161
Oral mucosal irritation potential of antimicrobial chemotherapy involving hydrogen peroxide photolysis with high-power laser irradiation for the treatment of periodontitis. Peer-reviewed

Shirato M, Nakamura K, Tenkumo T, Kano Y, Ishiyama K, Kanno T, Sasaki K, Niwano Y, Matsuura H

J Photochem Photobiol B.　doi: 10.1016/j.jphotobiol.201　2019/09
医師主導治験におけるラジカル殺菌歯周病治療器の臨床効果の検証無作為化比較試験 Peer-reviewed

佐々木啓一, 菅野太郎, 中村圭祐, 石山希里香, 山田康友, 白土翠, 庭野吉己, 萱場千恵, 池田浩治, 高木愛理, 山口拓洋

日本歯周病学会会誌　61　(春季特別)　127-127　2019/05
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
Hydroxyl radicals generated by hydrogen peroxide photolysis recondition biofilm-contaminated titanium surfaces for subsequent osteoblastic cell proliferation. Peer-reviewed

Nakamura K, Shirato M, Tenkumo T, Kanno T, Westerlund A, rtengren

Sci Rep.　doi: 10.1038/s41598-019-41126-　2019/03
Critical considerations on load-to-failure test for monolithic zirconia molar crowns. International-journal Peer-reviewed

Keisuke Nakamura, Shuhei Ankyu, Fritjof Nilsson, Taro Kanno, Yoshimi Niwano, Per Vult von Steyern, Ulf Örtengren

Journal of the mechanical behavior of biomedical materials　87　180-189　2018/11

DOI： 10.1016/j.jmbbm.2018.07.034 　

ISSN： 1751-6161

More details Close

Application of monolithic zirconia crowns (MZCs) with reduced thickness to the molar region has been proposed, but potential complications have yet to be fully evaluated in laboratory tests. The present study aimed to develop a clinically relevant load-to-failure test in combination with fatigue treatments involving thermal and mechanical cycling (TC and MC) to evaluate the fracture resistance of molar MZCs. MZCs with a minimal thickness of 0.5 mm were bonded to dies made of resin-based composite (RBC), epoxy resin (EP), or polyoxymethylene-copolymer (POM-C). The samples were either untreated (UT) or subjected to TC (5-55 °C for 1 × 105 cycles) and MC (300 N for 2.4 × 106 cycles). The stress generated by TC and MC was simulated by finite element modeling. The load-to-failure test was performed using an inverse V-shaped two-plane indenter and was followed by fractographic analysis. The median values of fracture load for MZC/RBC and MZC/EP in the TC group were significantly lower than those in the UT group. MC also decreased the median value of fracture load for MZC/RBC significantly, but not that for MZC/EP and MZC/POM-C. Fractography revealed that the fracture started in the cervical area in all groups, which is similar to clinically failed crowns. The simulation confirmed stress concentration at the cervical area in both TC and MC groups. The present study suggests that the load-to-failure test using a two-plane indenter could induce clinically relevant fracture of MZCs, the vulnerability of the MZCs depends largely on the die material employed, and MZCs are more likely to be damaged by thermal fatigue than mechanical fatigue.
Influence of microscale expansion and contraction caused by thermal and mechanical fatigue on retentive strength of CAD/CAM-generated resin-based composite crowns. International-journal Peer-reviewed

Shuhei Ankyu, Keisuke Nakamura, Akio Harada, Ryoichi Inagaki, Yusuke Katsuda, Taro Kanno, Yoshimi Niwano, Ulf Örtengren, Hiroshi Egusa

Journal of the mechanical behavior of biomedical materials　86　89-97　2018/10

DOI： 10.1016/j.jmbbm.2018.06.025 　

ISSN： 1751-6161

More details Close

CAD/CAM-generated resin-based composite crowns have been proposed as an inexpensive alternative to conventional crowns. However, concerns have been raised about crown loosening in clinical use. Therefore, the present in vitro study aimed to evaluate the influence of thermal and mechanical cycling (TC and MC) on retentive strength of CAD/CAM resin-based crowns in relation to microscale expansion and contraction caused by fatigue. Eighty standardized dies were produced using a resin-based composite material. Crowns were milled from resin-based composite (n = 40) and glass-ceramic blocks (n = 40; control) using a dental CAD/CAM system. The crowns bonded to the dies were subjected to TC (temperature: 5 and 55 °C, cycles: 50,000) and MC (load: 200 N, cycles: 1.2 million). After fatigue treatment, retentive strength of the crowns was evaluated by a crown pull-off test at a crosshead speed of 1 mm/min. Coefficient of thermal expansion (CTE) and modulus of elasticity (E-modulus) of each material were also analyzed to estimate the microscale expansion and contraction during TC and MC. TC and MC significantly reduced the retentive strength of the CAD/CAM resin-based crowns whereas that of the CAD/CAM ceramic crowns was only affected by TC. In addition, the resin-based crowns showed a higher number of crown loosening during TC than the ceramic crowns. Analyses of CTE and E-modulus indicated that the resin-based crowns would be more deformed during TC and MC than the ceramic crowns. The present study demonstrated that the resistance of crowns to microscale expansion and contraction caused by thermal and mechanical fatigue would play an important role in maintaining retentive strength.
Potential adverse effects of antimicrobial chemotherapy based on ultraviolet-A irradiation of polyphenols against the oral mucosa in hamsters and wounded skin in rats. International-journal Peer-reviewed

Keisuke Nakamura, Taichi Tenkumo, Takayuki Mokudai, Midori Shirato, Kirika Ishiyama, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

Journal of photochemistry and photobiology. B, Biology　187　96-105　2018/10

DOI： 10.1016/j.jphotobiol.2018.08.006 　

ISSN： 1011-1344

More details Close

Antimicrobial chemotherapy based on ultraviolet-A (UVA) irradiation of polyphenol solution has been proposed as an adjunctive treatment for dental caries. However, the safety of this treatment has not been thoroughly evaluated. Therefore, the aim of the present study was to assess the influence of this treatment on the oral mucosa in hamsters and wounded skin in rats. An oral mucosal irritation test was performed in hamsters. The cheek pouch was everted and treated with UVA irradiation (wavelength: 365 nm) of pure water, 1 mg/mL of caffeic acid, or 1 mg/mL of grape seed extract using a light-emitting diode at an irradiance of 275 mW/cm2. Each treatment was performed for 2 or 5 min and repeated three times. Macroscopic and histological evaluations were performed 24 h after the last treatment. We also examined the effects of the treatment on the healing process of skin wounds in rats. Full-thickness skin wounds created on the back of the rats were treated for 2 min as described above, but only once. The wound area was then assessed daily for 9 days. The results demonstrated that the treatment induced oral mucosal irritation depending on the irradiation time; however, it did not influence the wound healing process. The oral mucosal irritation potential of three treatment sessions performed for 2 and 5 min was minimal and mild to moderate, respectively, according to histological analysis. These findings suggest that the duration of treatment based on UVA irradiation of polyphenols in the oral cavity should be as short as possible, considering the clinical efficacy of the antimicrobial effects and the irritation potential.
A novel pathway for the photooxidation of catechin in relation to its prooxidative activity. International-journal Peer-reviewed

Shunichi Shishido, Rei Miyano, Takuji Nakashima, Hirotaka Matsuo, Masato Iwatsuki, Keisuke Nakamura, Taro Kanno, Hiroshi Egusa, Yoshimi Niwano

Scientific reports　8　(1)　12888-12888　2018/08/27

DOI： 10.1038/s41598-018-31195-x 　

More details Close

In the present study, we evaluated the prooxidative mode of action of photoirradiated (+)-catechin at 400 nm in relation to reactive oxygen species generation and its possible application to disinfection. Photoirradiation of (+)-catechin at a concentration of 1 mg/mL yielded not only hydrogen peroxide (H2O2) but hydroxyl radical (·OH) in a total amount of approximately 20 μM in 10 min. As a result, photoirradiated catechin killed Staphylococcus aureus, and a > 5-log reduction in viable bacteria counts was observed within 20 min. Liquid chromatography-high-resolution-electrospray ionization-mass spectrometry showed that photoirradiation decreased the (+)-catechin peak (molecular formula C15H14O6) whilst it increased two peaks of a substance with the molecular formula C15H12O6 with increasing irradiation time. Nuclear magnetic resonance analysis revealed that the two C15H12O6 peaks were allocated to intramolecular cyclization products that are enantiomers of each other. These results suggest that photoirradiation induces oxidation of (+)-catechin resulting in the reduction of oxygen to generate H2O2. This H2O2 is then homolytically cleaved to ·OH, and alongside this process, (+)-catechin is finally converted to two intramolecular cyclization products that are different from the quinone structure of the B ring, as proposed previously for the autoxidation and enzymatic oxidation of catechins.
遺伝子導入剤を含有したナノハイドロキシアパタイトーコラーゲンscaffoldの開発

天雲太一, 中村圭祐, 佐々木啓一, 菅野太郎

日本歯周病学会会誌　60　(春季特別)　130-130　2018/05
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
Proanthocyanidin-Rich Grape Seed Extract Modulates Intestinal Microbiota in Ovariectomized Mice. International-journal Peer-reviewed

Guangwen Jin, Yoshinori Asou, Kirika Ishiyama, Atsushi Okawa, Taro Kanno, Yoshimi Niwano

Journal of food science　83　(4)　1149-1152　2018/04

DOI： 10.1111/1750-3841.14098 　

ISSN： 0022-1147

More details Close

Grape-seed extract (GSE) is rich in proanthocyanidins (polymers of flavan-3-ols). GSE is well known to have various beneficial effects to health. The objective of this study was to examine the effect of dietary GSE on the intestinal microbiota in ovariectomized (OVX) mice as a model of menopause. Phylum-level analyses using 16S rRNA-targeted group-specific polymerase-chain reaction primers in fecal samples collected 8 weeks postoperatively from OVX mice revealed that the proportion of Firmicutes and Bacteroidetes populations became imbalanced as compared with that in sham-operated control mice. That is, the ratio of Firmicutes:Bacteroidetes populations in the OVX group were increased significantly. When OVX animals were given dietary GSE, the imbalanced proportion of Firmicutes and Bacteroidetes populations was normalized to that seen in control mice. In addition, the body weight of OVX animals measured at 6 weeks postoperatively was significantly higher than that in sham-operated control animals. Dietary GSE also prevented OVX animals from increasing body weight. Thus, we postulated that GSE can improve imbalanced populations of intestinal microbiota, leading to prevention of obesity under conditions of not only menopause but morbidity. PRACTICAL APPLICATION: The GSE has a great potential to be a functional food to improve dysbiosis in post-menopausal women.
Proanthocyanidin-rich grape seed extract prevent estrogen deficiency-induced metabolic disorders Peer-reviewed

Guangwen Jin, Alkebaier Aobulikasimu, Jinying Piao, Zulipiya Aibibula, Daisuke Koga, Hiroki Ochi, Kirika Ishiyama, Taro Kanno, Yoshimi Niwano, Atsushi Okawa, Yoshinori Asou

Journal of Medical and Dental Sciences　65　(2)　45-50　2018
Publisher: Tokyo Medical and Dental University
DOI： 10.11480/jmds.650201 　

ISSN： 2185-9132 1342-8810
Surface properties of dental zirconia ceramics affected by ultrasonic scaling and low-temperature degradation. International-journal Peer-reviewed

Kosuke Nakazawa, Keisuke Nakamura, Akio Harada, Midori Shirato, Ryoichi Inagaki, Ulf Örtengren, Taro Kanno, Yoshimi Niwano, Hiroshi Egusa

PloS one　13　(9)　e0203849　2018

DOI： 10.1371/journal.pone.0203849 　

More details Close

Zirconia (3Y-TZP) dental prostheses are widely used in clinical dentistry. However, the effect of ultrasonic scaling performed as a part of professional tooth cleaning on 3Y-TZP dental prostheses, especially in conjunction with low-temperature degradation (LTD), has not been fully investigated. The present study aimed to evaluate the influence of ultrasonic scaling and LTD on the surface properties of 3Y-TZP in relation to bacterial adhesion on the treated surface. 3Y-TZP specimens (4 × 4 × 2 mm) were polished and then subjected to autoclaving at 134°C for 100 h to induce LTD, followed by 10 rounds of ultrasonic scaling using a steel scaler tip for 1 min each. Surface roughness, crystalline structure, wettability, and hardness were analyzed by optical interferometry, X-ray diffraction analysis, contact angle measurement, and nano-indentation technique, respectively. Subsequently, bacterial adhesion onto the treated 3Y-TZP surface was evaluated using Streptococcus mitis and S. oralis. The results demonstrated that the combination of ultrasonic scaling and LTD significantly increased the Sa value (surface roughness parameter) of the polished 3Y-TZP surface from 1.6 nm to 117 nm. LTD affected the crystalline structure, causing phase transformation from the tetragonal to the monoclinic phase, and decreased both the contact angle and surface hardness. However, bacterial adhesion was not influenced by these changes in surface properties. The present study suggests that ultrasonic scaling may be acceptable for debridement of 3Y-TZP dental prostheses because it did not facilitate bacterial adhesion even in the combination with LTD, although it did cause slight roughening of the surface.
Oral mucosal irritation study in hamster to evaluate a therapeutic apparatus using hydrogen peroxide photolysis for periodontitis treatment Peer-reviewed

Yoshimi Niwano, Kazunori Konno, Takeshi Matayoshi, Keisuke Nakamura, Taro Kanno, Keiichi Sasaki

REGULATORY TOXICOLOGY AND PHARMACOLOGY　90　206-213　2017/11

DOI： 10.1016/j.yrtph.2017.09.019 　

ISSN： 0273-2300

eISSN： 1096-0295
Adjunctive antimicrobial chemotherapy based on hydrogen peroxide photolysis for non-surgical treatment of moderate to severe periodontitis: a randomized controlled trial Peer-reviewed

Taro Kanno, Keisuke Nakamura, Kirika Ishiyama, Yasutomo Yamada, Midori Shirato, Yoshimi Niwano, Chie Kayaba, Koji Ikeda, Airi Takagi, Takuhiro Yamaguchi, Keiichi Sasaki

SCIENTIFIC REPORTS　7　(1)　12247　2017/09

DOI： 10.1038/s41598-017-12514-0 　

ISSN： 2045-2322
Time-kill kinetic analysis of antimicrobial chemotherapy based on hydrogen peroxide photolysis against Streptococcus mutans biofilm Peer-reviewed

Midori Shirato, Keisuke Nakamura, Taro Kanno, Peter Lingstrom, Yoshimi Niwano, Ulf Ortengren

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY　173　434-440　2017/08

DOI： 10.1016/j.jphotobiol.2017.06.023 　

ISSN： 1011-1344
Photo-irradiated caffeic acid exhibits antimicrobial activity against Streptococcus mutans biofilms via hydroxyl radical formation Peer-reviewed

Keisuke Nakamura, Midori Shirato, Taro Kanno, Peter Lingstrom, Ulf Ortengren, Yoshimi Niwano

SCIENTIFIC REPORTS　7　(1)　6353　2017/07

DOI： 10.1038/s41598-017-07007-z 　

ISSN： 2045-2322
Efficacy and safety of a therapeutic apparatus using hydrogen peroxide photolysis to treat dental and periodontal infectious diseases Peer-reviewed

Hirohisa Sato, Yoshimi Niwano, Keisuke Nakamura, Takayuki Mokudai, Hiroyo Ikai, Taro Kanno, Hiroshi Egusa

JOURNAL OF TOXICOLOGICAL SCIENCES　41　(6)　793-799　2016/12

DOI： 10.2131/jts.41.793 　

ISSN： 0388-1350

eISSN： 1880-3989
Antimicrobial activity of hydroxyl radicals generated by hydrogen peroxide photolysis against Streptococcus mutans biofilm Peer-reviewed

Keisuke Nakamura, Midori Shirato, Taro Kanno, Ulf Ortengren, Peter Lingstrom, Yoshimi Niwano

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS　48　(4)　373-380　2016/10

DOI： 10.1016/j.ijantimicag.2016.06.007 　

ISSN： 0924-8579

eISSN： 1872-7913
Bactericidal Action of Photodynamic Antimicrobial Chemotherapy (PACT) with Photosensitizers Used as Plaque-Disclosing Agents against Experimental Biofilm Peer-reviewed

Kirika Ishiyama, Keisuke Nakamura, Taro Kanno, Yoshimi Niwano

BIOCONTROL SCIENCE　21　(3)　187-191　2016/09

DOI： 10.4265/bio.21.187 　

ISSN： 1342-4815

eISSN： 1884-0205
Fatigue analysis of computer-aided design/computer-aided manufacturing resin-based composite vs. lithium disilicate glass-ceramic Peer-reviewed

Shuhei Ankyu, Keisuke Nakamura, Akio Harada, Guang Hong, Taro Kanno, Yoshimi Niwano, Ulf Ortengren, Hiroshi Egusa

EUROPEAN JOURNAL OF ORAL SCIENCES　124　(4)　387-395　2016/08

DOI： 10.1111/eos.12278 　

ISSN： 0909-8836

eISSN： 1600-0722
CAD/CAM冠用コンポジットレジンの疲労動態解析

安久修平, 原田章生, 菅野太郎, 江草宏

日本補綴歯科学会誌　8　(特別号)　245-245　2016/07
Publisher: (公社)日本補綴歯科学会
ISSN： 1883-4426

eISSN： 1883-6860
Effect of low-temperature degradation on the mechanical and microstructural properties of tooth-colored 3Y-TZP ceramics. Peer-reviewed

Nakamura K, Harada A, Ono M, Shibasaki H, Kanno T, Niwano Y, Milleding P, Ortengren U

Journal of the mechanical behavior of biomedical materials　53　301-311　2016/01

DOI： 10.1016/j.jmbbm.2015.08.031 　
Effect of cements on fracture resistance of monolithic zirconia crowns. Peer-reviewed

Nakamura K, Mouhat M, Nergård JM, Lægreid SJ, Kanno T, Milleding P, Örtengren U

Acta biomaterialia odontologica Scandinavica　2　(1)　12-19　2016/01

DOI： 10.3109/23337931.2015.1129908 　
Acute Phosphate Nephropathy with Diffuse Tubular Injury Despite Limited Calcium Phosphate Deposition Peer-reviewed

Yosuke Yamada, Makoto Harada, Akinori Yamaguchi, Mai Sugiyama, Taro Kanno, Koji Hashimoto, Takashi Ehara, Hisashi Shimojo, Hidekazu Shigematsu, Yuji Kamijo

INTERNAL MEDICINE　55　(16)　2229-2235　2016

DOI： 10.2169/internalmedicine.55.5864 　

ISSN： 0918-2918

eISSN： 1349-7235
Cutting efficiency of diamond burs operated with electric high-speed dental handpiece on zirconia Peer-reviewed

Keisuke Nakamura, Yusuke Katsuda, Shuhei Ankyu, Akio Harada, Taichi Tenkumo, Taro Kanno, Yoshimi Niwano, Hiroshi Egusa, Percy Milleding, Ulf Ortengren

EUROPEAN JOURNAL OF ORAL SCIENCES　123　(5)　375-380　2015/10

DOI： 10.1111/eos.12211 　

ISSN： 0909-8836

eISSN： 1600-0722
Bactericidal Activity and Mechanism of Photoirradiated Polyphenols against Gram-Positive and -Negative Bacteria Peer-reviewed

Keisuke Nakamura, Kirika Ishiyama, Hong Sheng, Hiroyo Ikai, Taro Kanno, Yoshimi Niwano

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY　63　(35)　7707-7713　2015/09

DOI： 10.1021/jf5058588 　

ISSN： 0021-8561

eISSN： 1520-5118
Cytoprotective Effects of Grape Seed Extract on Human Gingival Fibroblasts in Relation to Its Antioxidant Potential (vol 10, e0134704, 2015) Peer-reviewed

Yusuke Katsuda, Yoshimi Niwano, Takuji Nakashima, Takayuki Mokudai, Keisuke Nakamura, Satomi Oizumi, Taro Kanno, Hiroyasu Kanetaka, Hiroshi Egusa

PLOS ONE　10　(9)　e0138394　2015/09

DOI： 10.1371/journal.pone.0138394 　

ISSN： 1932-6203
Cytoprotective Effects of Grape Seed Extract on Human Gingival Fibroblasts in Relation to Its Antioxidant Potential Peer-reviewed

Yusuke Katsuda, Yoshimi Niwano, Takuji Nakashima, Takayuki Mokudai, Keisuke Nakamura, Satomi Oizumi, Taro Kanno, Hiroyasu Kanetaka, Hiroshi Egusa

PLOS ONE　10　(8)　e0134704　2015/08

DOI： 10.1371/journal.pone.0134704 　

ISSN： 1932-6203
The influence of low-temperature degradation and cyclic loading on the fracture resistance of monolithic zirconia molar crowns. Peer-reviewed

Nakamura K, Harada A, Kanno T, Inagaki R, Niwano Y, Milleding P, Ortengren U

Journal of the mechanical behavior of biomedical materials　47　49-56　2015/07

DOI： 10.1016/j.jmbbm.2015.03.007 　
Bactericidal Effect of Photolysis of H2O2 in Combination with Sonolysis of Water via Hydroxyl Radical Generation Peer-reviewed

Hong Sheng, Keisuke Nakamura, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

PLOS ONE　10　(7)　e0132445　2015/07

DOI： 10.1371/journal.pone.0132445 　

ISSN： 1932-6203
Fracture resistance of computer-aided design/computer-aided manufacturing generated composite resin-based molar crowns Peer-reviewed

Akio Harada, Keisuke Nakamura, Taro Kanno, Ryoichi Inagaki, Ulf Ortengren, Yoshimi Niwano, Keiichi Sasaki, Hiroshi Egusa

EUROPEAN JOURNAL OF ORAL SCIENCES　123　(2)　122-129　2015/04

DOI： 10.1111/eos.12173 　

ISSN： 0909-8836

eISSN： 1600-0722
Synergistic interaction between wavelength of light and concentration of H2O2 in bactericidal activity of photolysis of H2O2 Peer-reviewed

Toshihide Toki, Keisuke Nakamura, Michiko Kurauchi, Taro Kanno, Yusuke Katsuda, Hiroyo Ikai, Eisei Hayashi, Hiroshi Egusa, Keiichi Sasaki, Yoshimi Niwano

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　119　(3)　358-362　2015/03

DOI： 10.1016/j.jbiosc.2014.08.015 　

ISSN： 1389-1723

eISSN： 1347-4421
Postantifungal-like effect of sublethal treatment of Candida albicans with acid-electrolyzed water Peer-reviewed

Takayuki Mokuclai, Taro Kanno, Yoshimi Niwano

ARCHIVES OF ORAL BIOLOGY　60　(3)　479-487　2015/03

DOI： 10.1016/j.archoralbio.2014.12.008 　

ISSN： 0003-9969

eISSN： 1879-1506
Involvement of reactive oxygen species in the cytotoxic effect of acid-electrolyzed water Peer-reviewed

Takayuki Mokudai, Taro Kanno, Yoshimi Niwano

JOURNAL OF TOXICOLOGICAL SCIENCES　40　(1)　13-19　2015/02

DOI： 10.2131/jts.40.13 　

ISSN： 0388-1350

eISSN： 1880-3989
Fracture resistance of monolithic zirconia molar crowns with reduced thickness Peer-reviewed

Keisuke Nakamura, Akio Harada, Ryoichi Inagaki, Taro Kanno, Yoshimi Niwano, Percy Milleding, Ulf Ortengren

ACTA ODONTOLOGICA SCANDINAVICA　73　(8)　602-608　2015

DOI： 10.3109/00016357.2015.1007479 　

ISSN： 0001-6357

eISSN： 1502-3850
Acceleration of Proliferative Response of Mouse Fibroblasts by Short-Time Pretreatment with Polyphenols Peer-reviewed

Makoto Tsuruya, Yoshimi Niwano, Keisuke Nakamura, Taro Kanno, Takuji Nakashima, Hiroshi Egusa, Keiichi Sasaki

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY　174　(6)　2223-2235　2014/11

DOI： 10.1007/s12010-014-1124-7 　

ISSN： 0273-2289

eISSN： 1559-0291
Cytoprotective Effect of Short-Term Pretreatment with Proanthocyanidin on Human Gingival Fibroblasts Exposed to Harsh Environmental Conditions Peer-reviewed

Michiko Kurauchi, Yoshimi Niwano, Midori Shirato, Taro Kanno, Keisuke Nakamura, Hiroshi Egusa, Keiichi Sasaki

PLOS ONE　9　(11)　e113403　2014/11

DOI： 10.1371/journal.pone.0113403 　

ISSN： 1932-6203
Blue light injures corneal epithelial cells in the mitotic phase in vitro Peer-reviewed

Yoshimi Niwano, Taro Kanno, Atsuo Iwasawa, Masahiko Ayaki, Kazuo Tsubota

BRITISH JOURNAL OF OPHTHALMOLOGY　98　(7)　990-U244　2014/07

DOI： 10.1136/bjophthalmol-2014-305205 　

ISSN： 0007-1161

eISSN： 1468-2079
Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide Peer-reviewed

Yu Odashima, Keisuke Nakamura, Hiroyo Ikai, Taro Kanno, Luiz Meirelles, Keiichi Sasaki, Yoshimi Niwano

JOURNAL OF CHEMOTHERAPY　26　(2)　92-100　2014/04

DOI： 10.1179/1973947813Y.0000000114 　

ISSN： 1120-009X

eISSN： 1973-9478
A Case of Perio-Implant-Prosthesis in a Patient with Severe Generalized Chronic Periodontitis

Kanno Taro

Annals of Japan Prosthodontic Society　6　(1)　95-98　2014
Publisher: Japan Prosthodontic Society
DOI： 10.2186/ajps.6.95 　

ISSN： 1883-4426

More details Close

Patients: A 53-year-old female with the chief complaints of pain of the upper right molar region and pathologic teeth mobility was diagnosed as severe generalized chronic periodontitis with masticatory disorder. Cause-related periodontal therapy and well-established supra-gingival self-performed plaque control by the patient resulted in improvement in periodontal condition. Then, orthodontic treatment and single-implant therapy were performed. The implant was installed along the anterior wall of the maxillary sinus in a tilted manner. Masticatory function and esthetics were recovered by a combined tooth-implant-supported fixed dental prosthesis. Discussion: The perio-implant-prosthesis based on the shortened dental arch concept led to high satisfaction of this patient with severe generalized chronic periodontitis. Conclusion: The perio-implant-prosthesis is acceptable under meticulous plaque control by both the patient and dental professional.
細菌、ウィルスに対するPDTの研究成果歯垢染色剤に含まれる各種キサンテン系色素を光感受性物質とした一重項酸素依存性光線力学殺菌療法の比較 Peer-reviewed

庭野吉己, 石山希里香, 中村圭祐, 猪飼紘代, 菅野太郎, 佐々木啓一

日本レーザー医学会誌　34　(3)　326-326　2013/10
Publisher: (NPO)日本レーザー医学会
ISSN： 0288-6200

eISSN： 1881-1639
Synergistic Effect of Proanthocyanidin on the Bactericidal Action of the Photolysis of H2O2 Peer-reviewed

Hiroyo Ikai, Keisuke Nakamura, Taro Kanno, Midori Shirato, Luiz Meirelles, Keiichi Sasaki, Yoshimi Niwano

BIOCONTROL SCIENCE　18　(3)　137-141　2013/09

ISSN： 1342-4815

eISSN： 1884-0205
Influence of a new denture cleaning technique based on photolysis of H2O2 on the mechanical properties and color change of acrylic denture base resin Peer-reviewed

Tatsuro Nakahara, Akio Harada, Yasutomo Yamada, Yu Odashima, Keisuke Nakamura, Ryoichi Inagaki, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

DENTAL MATERIALS JOURNAL　32　(4)　529-536　2013/08

DOI： 10.4012/dmj.2013-047 　

ISSN： 0287-4547
過酸化水素の光分解および水の超音波分解を併用したヒドロキシルラジカル生成系の殺菌効果 Peer-reviewed

生宏, 中村圭祐, 菅野太郎, 佐々木啓一, 庭野吉己

超音波医学　40　(4)　427-427　2013/07
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
過酸化水素光分解殺菌技術を応用した新規歯周病治療器の開発 Peer-reviewed

菅野太郎, 中村圭祐, 猪飼紘代, 庭野吉己, 佐々木啓一

日本歯周病学会会誌　55　(春季特別)　90-90　2013/04
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110

eISSN： 1880-408X
Photo-Irradiation of Proanthocyanidin as a New Disinfection Technique via Reactive Oxygen Species Formation Peer-reviewed

Keisuke Nakamura, Midori Shirato, Hiroyo Ikai, Taro Kanno, Keiichi Sasaki, Masahiro Kohno, Yoshimi Niwano

PLOS ONE　8　(3)　e60053　2013/03

DOI： 10.1371/journal.pone.0060053 　

ISSN： 1932-6203
In vitro bactericidal activity of photo-irradiated oxydol products via hydroxyl radical generation. Peer-reviewed

Akira Oyamada, Hiroyo Ikai, Keisuke Nakamura, Eisei Hayashi, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

Biocontrol science　18　(2)　83-8　2013

ISSN： 1342-4815

eISSN： 1884-0205

More details Close

The oxidative power of hydroxyl radicals has been applied to disinfection systems for the purpose of oral hygiene by utilizing blue light-induced photolysis of hydrogen peroxide (H₂O₂) in our laboratory. In the present study, the bactericidal potential of blue light-irradiated oxydol products via hydroxyl radical generation was compared with that of 3% (w/v) H₂O₂. Eleven commercially available oxydol products were used in the present study. Even though a few of the products that contained ethanol, a hydroxyl radical scavenger, as an additive showed slightly lower hydroxyl radical yield as compared with 3% (w/v) H₂O₂, the blue-light irradiation of each oxydol product for 3 min showed similar or superior bactericidal activity against Staphylococcus aureus to that of 3% (w/v) H₂O₂. The results strongly suggest that any of the oxydol products tested in the present study can be used as a source of hydroxyl radicals for the disinfection technique developed in our laboratory.
In vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide. International-journal Peer-reviewed

Hiroyo Ikai, Yu Odashima, Taro Kanno, Keisuke Nakamura, Midori Shirato, Keiichi Sasaki, Yoshimi Niwano

PloS one　8　(11)　e81316　2013

DOI： 10.1371/journal.pone.0081316 　

More details Close

The purpose of the present study was to evaluate the risk of inducing bacterial resistance to disinfection treatment with photolysis of H2O2 and comparing this with existing antibacterial agents. We tested seven antibacterial agents, including amoxicillin, cefepime hydrochloride, erythromycin, ofloxacin, clindamycin hydrochloride, ciprofloxacin hydrochloride, and minocycline hydrochloride, as positive controls for validation of the assay protocol. For all of the agents tested, at least one of the four bacterial species (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Streptococcus salivarius) was resistant to these agents by repeated exposure to subinhibitory concentrations of the agents up to 10 times. In contrast, antibacterial activity against any of the bacterial species tested (S. aureus, E. faecalis, E. coli, S. salivarius, Pseudomonas aeruginosa, Streptococcus mutans, and Aggregatibacter actinomycetemcomitans) was not affected by repeated exposure to the disinfection treatment up to 40 times. This finding suggested that the risk of inducing bacterial resistance by disinfection treatment was low. The active ingredient of this disinfection treatment is hydroxyl radicals generated by photolysis of H2O2. Therefore, hydroxyl radicals interact with several cell structures and different metabolic pathways in microbial cells, probably resulting in a lack of development of bacterial resistance. In conclusion, disinfection treatment with photolysis of H2O2 appears to be a potential alternative for existing antimicrobial agents in terms of a low risk of inducing bacterial resistance.
Corrosive effect of disinfection solution containing hydroxyl radicals generated by photolysis of H2O2 on dental metals Peer-reviewed

Keisuke Nakamura, Yasutomo Yamada, Yukyo Takada, Takayuki Mokudai, Hiroyo Ikai, Ryoichi Inagaki, Taro Kanno, Keiichi Sasaki, Masahiro Kohno, Yoshimi Niwano

DENTAL MATERIALS JOURNAL　31　(6)　941-946　2012/11

DOI： 10.4012/dmj.2012-098 　

ISSN： 0287-4547
Erratum to Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats (J. Toxicol. Sci., (2012), 37, (329-335))

Yamada Y, Mokudai T, Nakamura K, Hayashi E, Kawana Y, Kanno T, Sasaki K, Niwano Y

J Toxicol Sci　37　1091　2012/10

ISSN： 1880-3989
Bactericidal Action of Photoirradiated Gallic Acid via Reactive Oxygen Species Formation Peer-reviewed

Keisuke Nakamura, Yasutomo Yamada, Hiroyo Ikai, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY　60　(40)　10048-10054　2012/10

DOI： 10.1021/jf303177p 　

ISSN： 0021-8561
Presence of Hydrogen Peroxide, a Source of Hydroxyl Radicals, in Acid Electrolyzed Water Peer-reviewed

Takayuki Mokudai, Keisuke Nakamura, Taro Kanno, Yoshimi Niwano

PLOS ONE　7　(9)　e46392　2012/09

DOI： 10.1371/journal.pone.0046392 　

ISSN： 1932-6203
過酸化水素光分解殺菌法に対する熱エネルギーの相乗的効果 Peer-reviewed

白土翠, 猪飼紘代, 中村圭祐, 林栄成, 菅野太郎, 佐々木啓一, 庭野吉己

日本歯科医師会雑誌　65　(5)　615-615　2012/08
Publisher: (公社)日本歯科医師会
ISSN： 0047-1763
プラーク染色剤を用いた新しい光線力学殺菌療法の基礎的検討 Peer-reviewed

石山希里香, 中村圭祐, 猪飼紘代, 菅野太郎, 佐々木啓一, 庭野吉己

日本歯科医師会雑誌　65　(5)　615-615　2012/08
Publisher: (公社)日本歯科医師会
ISSN： 0047-1763
In vitro and in vivo anti-Staphylococcus aureus activities of a new disinfection system utilizing photolysis of hydrogen peroxide Peer-reviewed

Eisei Hayashi, Takayuki Mokudai, Yasutomo Yamada, Keisuke Nakamura, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　114　(2)　193-197　2012/08

DOI： 10.1016/j.jbiosc.2012.03.020 　

ISSN： 1389-1723
Novel Denture-Cleaning System Based on Hydroxyl Radical Disinfection Peer-reviewed

Taro Kanno, Keisuke Nakamura, Hiroyo Ikai, Eisei Hayashi, Midori Shirato, Takayuki Mokudai, Atsuo Iwasawa, Yoshimi Niwano, Masahiro Kohno, Keiichi Sasaki

INTERNATIONAL JOURNAL OF PROSTHODONTICS　25　(4)　376-380　2012/07

ISSN： 0893-2174
Literature review of the role of hydroxyl radicals in chemically-induced mutagenicity and carcinogenicity for the risk assessment of a disinfection system utilizing photolysis of hydrogen peroxide Peer-reviewed

Taro Kanno, Keisuke Nakamura, Hiroyo Ikai, Katsushi Kikuchi, Keiichi Sasaki, Yoshimi Niwano

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION　51　(1)　9-14　2012/07

DOI： 10.3164/jcbn.11-105 　

ISSN： 0912-0009

eISSN： 1880-5086
Determination of reactive oxygen species generated by phorbol 12-myristate 13-acetate-stimulated oral polymorphonuclear cells from healthy human volunteers without any dental problems Peer-reviewed

Noriko Yaekashiwa, Emiko Sato, Keisuke Nakamura, Atsuo Iwasawa, Akihito Kudo, Taro Kanno, Masahiro Kohno, Yoshimi Niwano

ARCHIVES OF ORAL BIOLOGY　57　(6)　636-641　2012/06

DOI： 10.1016/j.archoralbio.2011.10.020 　

ISSN： 0003-9969

eISSN： 1879-1506
Influence of grain size and veneer firing process on the flexural strength of zirconia ceramics Peer-reviewed

Keisuke Nakamura, Erik Adolfsson, Percy Milleding, Taro Kanno, Ulf Ortengren

EUROPEAN JOURNAL OF ORAL SCIENCES　120　(3)　249-254　2012/06

DOI： 10.1111/j.1600-0722.2012.00958.x 　

ISSN： 0909-8836
Bactericidal Action of Photogenerated Singlet Oxygen from Photosensitizers Used in Plaque Disclosing Agents Peer-reviewed

Kirika Ishiyama, Keisuke Nakamura, Hiroyo Ikai, Taro Kanno, Masahiro Kohno, Keiichi Sasaki, Yoshimi Niwano

PLOS ONE　7　(5)　e37871　2012/05

DOI： 10.1371/journal.pone.0037871 　

ISSN： 1932-6203
Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats Peer-reviewed

Yasutomo Yamada, Takayuki Mokudai, Keisuke Nakamura, Eisei Hayashi, Yoshiko Kawana, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

JOURNAL OF TOXICOLOGICAL SCIENCES　37　(2)　329-335　2012/04

ISSN： 0388-1350

eISSN： 1880-3989
Synergistic Effect of Thermal Energy on Bactericidal Action of Photolysis of H2O2 in Relation to Acceleration of Hydroxyl Radical Generation Peer-reviewed

Midori Shirato, Hiroyo Ikai, Keisuke Nakamura, Eisei Hayashi, Taro Kanno, Keiichi Sasaki, Masahiro Kohno, Yoshimi Niwano

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY　56　(1)　295-301　2012/01

DOI： 10.1128/AAC.05158-11 　

ISSN： 0066-4804
Microbial resistance in relation to catalase activity to oxidative stress induced by photolysis of hydrogen peroxide Peer-reviewed

Keisuke Nakamura, Taro Kanno, Takayuki Mokudai, Atsuo Iwasawa, Yoshimi Niwano, Masahiro Kohno

MICROBIOLOGY AND IMMUNOLOGY　56　(1)　48-55　2012/01

DOI： 10.1111/j.1348-0421.2011.00400.x 　

ISSN： 0385-5600
Reevaluation of analytical methods for photogenerated singlet oxygen Peer-reviewed

Keisuke Nakamura, Kirika Ishiyama, Hiroyo Ikai, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano, Masahiro Kohno

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION　49　(2)　87-95　2011/09

DOI： 10.3164/jcbn.10-125 　

ISSN： 0912-0009

eISSN： 1880-5086
Photolysis of Hydrogen Peroxide, an Effective Disinfection System via Hydroxyl Radical Formation Peer-reviewed

Hiroyo Ikai, Keisuke Nakamura, Midori Shirato, Taro Kanno, Atsuo Iwasawa, Keiichi Sasaki, Yoshimi Niwano, Masahiro Kohno

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY　54　(12)　5086-5091　2010/12

DOI： 10.1128/AAC.00751-10 　

ISSN： 0066-4804
A retrospective study of fixed dental prostheses without regular maintenance Peer-reviewed

Hiroyo Ikai, Taro Kanno, Kohei Kimura, Keiichi Sasaki

JOURNAL OF PROSTHODONTIC RESEARCH　54　(4)　173-178　2010/10

DOI： 10.1016/j.jpor.2010.04.003 　

ISSN： 1883-1958

eISSN： 2212-4632
Reevaluation of Quantitative ESR Spin Trapping Analysis of Hydroxyl Radical by Applying Sonolysis of Water as a Model System Peer-reviewed

Nakamura Keisuke, Kanno Taro, Ikai Hiroyo, Sato Emiko, Mokudai Takayuki, Niwano Yoshimi, Ozawa Toshihiko, Kohno Masahiro

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　83　(9)　1037-1046　2010/09/15

DOI： 10.1246/bcsj.20100078 　

ISSN： 0009-2673
A novel analytical method to evaluate directly catalase activity of microorganisms and mammalian cells by ESR oximetry Peer-reviewed

Keisuke Nakamura, Taro Kanno, Takayuki Mokudai, Atsuo Iwasawa, Yoshimi Niwano, Masahiro Kohno

FREE RADICAL RESEARCH　44　(9)　1036-1043　2010/09

DOI： 10.3109/10715762.2010.495750 　

ISSN： 1071-5762
Zirconia as a Dental Implant Abutment Material: A Systematic Review Peer-reviewed

Keisuke Nakamura, Taro Kanno, Percy Milleding, Ulf Ortengren

INTERNATIONAL JOURNAL OF PROSTHODONTICS　23　(4)　299-309　2010/07

ISSN： 0893-2174
Transmitted laser beam power of the resin washed by experimental washing machine for dentures Peer-reviewed

Eisei Hayashi, Mika Tada, Taro Kanno, Hiroyo Ikai, Keisuke Nakamura, Masahiro Kohno

INTERFACE ORAL HEALTH SCIENCE 2009　257-+　2010

DOI： 10.1007/978-4-431-99644-6_69 　
The evaluation of the dental disinfection device with low concentration of H2O2 and laser diode Peer-reviewed

Hiroyo Ikai, Taro Kanno, Keisuke Nakamura, Eisei Hayashi, Akihito Kudo, Masahiro Kohno

INTERFACE ORAL HEALTH SCIENCE 2009　259-+　2010

DOI： 10.1007/978-4-431-99644-6_70 　
Bactericidal effect of photodynamic therapy Peer-reviewed

Nakamura Keisuke, Tada Mika, Kanno Taro, Ikai Hiroyo, Hayashi Eisei, Mokudai Takayuki, Kohno Masahiro

INTERFACE ORAL HEALTH SCIENCE 2009　232-+　2010

DOI： 10.1007/978-4-431-99644-6_59 　
Denture plaque removal efficacy of denture cleansing device utilizing radical disinfection ability of activated low concentration H2O2 Peer-reviewed

Kanno Taro, Hayashi Eisei, Ikai Hiroyo, Nakamura Keisuke, Mokudai Takayuki, Kohno Masahiro, Sasaki Keiichi

INTERFACE ORAL HEALTH SCIENCE 2009　252-+　2010

DOI： 10.1007/978-4-431-99644-6_67 　
Radical Sterilization Properties of Hydrogen Peroxide Activated by LED (386nm) Irradiation for Oral Bacterium : A Pilot Study

KANNO Taro, NAKAMURA Keisuke, IKAI Hiroyo, MOKUDAI Takayuki, HAYASHI Eisei, KOHNO Masahiro

Prosthodont Res. Pract.　7　(2)　138-140　2008/07/01
Publisher: Japan Prosthodontic Society
DOI： 10.2186/prp.7.138 　

ISSN： 1347-7021
[What prosthodontic therapy should we select for periodontally compromised patients? Part 1: Review of the literature focusing on implant therapy for periodontally compromised patients]. Peer-reviewed

Kanno T, Nakamura K, Hayashi E, Kimura K, Hirooka H, Kimura K

Nihon Hotetsu Shika Gakkai zasshi　52　(2)　135-142　2008/04

ISSN： 0389-5386
[What prosthodontic therapy should we select for periodontally compromised patients? Part 2: Review of the literature focusing on conventional prosthodontic therapy for periodontally compromised patients and clinical implication (RPD vs FPD vs implant)]. Peer-reviewed

Kanno T, Nakamura K, Hayashi E, Kimura K, Hirooka H, Kimura K

Nihon Hotetsu Shika Gakkai zasshi　52　(2)　143-149　2008/04

ISSN： 0389-5386
What Prosthodontic Therapy Should We Select for Periodontally Compromised Patients?-Part 2: A Review of the Literature Focusing on Conventional Prosthodontic Therapy for Periodontally Compromised Patients and Clinical Implication (RPD vs FPD vs Implant)-:—Part 2: A Review of the Literature Focusing on Conventional Prosthodontic Therapy for Periodontally Compromised Patients and Clinical Implication— (RPD vs FPD vs Implant)

Kanno Taro, Nakamura Keisuke, Hayashi Eisei, Kimura Kohei, Hirooka Hideaki, Kimura Kohei

Journal of Prosthodontic Research　52　(2)　143-149　2008
Publisher: Japan Prosthodontic Society
DOI： 10.2186/jjps.52.143 　

ISSN： 0389-5386

More details Close

Purpose: To review the clinical literature on fixed partial denture (FPD) and removable partial denture (RPD) treatment for periodontally compromised patients with partial dentate. In addition, prosthodontic management in periodontitis-susceptible subjects was evaluated from the results of Part 1 and Part 2. Study selection: Clinical studies that documented survival rates of FPD in periodontally compromised patients were selected and reviewed. Results: There was no RPD study that fulfilled the criteria of this review paper. On the other hand, 8 reports that were reviewed in this study showed good survival rate of FPD in long-term clinical results. Conclusion: Since the number of reports on RPD is very few, it was difficult to evaluate the RPD treatment for periodontally compromised patients. From the results of some long-term follow-up retrospective studies, however, it was suggested that FPD of high-risk design showed excellent results. Regarding management in periodontits-susceptible subjects, it should be discussed whether positive prosthodontic treatment is necessary. Strict plaque control by both doctors and patients before/after treatment is indispensable for prosthodontic management in periodontally compromised patients.
[A review of clinical follow-up studies focusing on pretreatment conditions of abutment and clinical examination parameters]. Peer-reviewed

Ikai H, Kanno T, Kimura K

Nihon Hotetsu Shika Gakkai zasshi　50　(2)　245-255　2006/04

ISSN： 0389-5386

Show all ︎Show first 5

Misc. 89

カテキンの光酸化反応機構の解明および活性酸素を介した殺菌活性評価

宍戸駿一, 宮野怜, 中島琢自, 松尾洋孝, 岩月正人, 中村圭祐, 菅野太郎, 江草宏, 庭野吉己, 庭野吉己

日本ポリフェノール学会学術集会プログラム・講演抄録集　15th　2022
遺伝子導入剤を含有したナノハイドロキシアパタイトーコラーゲンscaffoldの開発

天雲太一, 中村圭祐, 佐々木啓一, 菅野太郎

日本歯周病学会会誌　60　(春季特別)　130-130　2018/05
Publisher: (NPO)日本歯周病学会
ISSN： 0385-0110
カフェイン酸に対するUV-A照射で得られる殺菌作用と口腔粘膜刺激性の評価

中村圭祐, 天雲太一, 目代貴之, 白土翠, 石山希里香, 菅野太郎, 佐々木啓一, 庭野吉己

日本防菌防黴学会年次大会要旨集　45th　2018
カテキンの光酸化を介した殺菌活性と光酸化機序の解明-その2-

宍戸駿一, 宮野怜, 中島琢自, 松尾洋孝, 岩月正人, 中村圭祐, 菅野太郎, 江草宏, 庭野吉己

日本防菌防黴学会年次大会要旨集　45th　2018
カテキンの光酸化を介した殺菌活性と光酸化機序の解明

宍戸駿一, 宮野怜, 中島琢自, 中島琢自, 佐藤恵美子, 中村圭祐, 菅野太郎, 江草宏, 庭野吉己

日本防菌防黴学会年次大会要旨集　44th　2017
CAD/CAM冠用コンポジットレジンの疲労動態解析

安久修平, 原田章生, 菅野太郎, 江草宏

日本補綴歯科学会誌(Web)　8　245 (WEB ONLY)　2016/07

ISSN： 1883-6860
Blue light induces oxidative damage in human ocular surface cells in culture

Masahiko Ayaki, Yoshimi Niwano, Taro Kanno, Kazuo Tsubota

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
過酸化水素光分解殺菌技術における光の波長と過酸化水素濃度の相乗作用

唐木俊英, 倉内美智子, 菅野太郎, 勝田悠介, 猪飼紘代, 林栄成, 佐々木啓一, 江草宏

日本補綴歯科学会誌　7　(特別号)　154-154　2015/05
Publisher: (公社)日本補綴歯科学会
ISSN： 1883-4426

eISSN： 1883-6860
過酸化水素光分解殺菌技術における光の波長と過酸化水素濃度の相乗作用

唐木俊英, 倉内美智子, 菅野太郎, 勝田悠介, 猪飼紘代, 林栄成, 佐々木啓一, 江草宏

日本補綴歯科学会誌(Web)　7　2015

ISSN： 1883-6860
ワイン製造残渣・澱水抽出物への光照射による殺菌活性

塚田愛, 塚田愛, SHENG Hong, 目代貴之, 菅野太郎, 蒲池利章, 庭野吉己

日本防菌防黴学会年次大会要旨集　42nd　2015
有機物存在下でのpH調整混合電解水の抗菌活性

古田美香, 小田桐慎一郎, 川名喜子, 毛呂宇吉郎, 岩井邦雄, 菅野稔, 目代貴之, 菅野太郎, 庭野吉己

日本防菌防黴学会年次大会要旨集　42nd　2015
CAD/CAM法による大臼歯硬質レジンジャケットクラウンの強度試験

原田章生, 菅野太郎, 稲垣亮一, 佐々木啓一

日本補綴歯科学会学術大会プログラム・抄録集　123rd　204　2014/04/01

ISSN： 1883-4426
過酸化水素光分解殺菌技術を応用した新規歯周病治療器の安全性と有効性の検証

猪飼紘代, 目代貴之, 中村圭祐, 菅野太郎, 庭野吉己

日本防菌防黴学会年次大会要旨集　41st　2014
Candida albicansに対する希釈酸性電解水のpost-antifungal like effectと活性酸素の関与

目代貴之, 菅野太郎, 庭野吉己

日本防菌防黴学会年次大会要旨集　41st　2014
酸性電解水の細胞毒性における活性酸素の関与

庭野吉己, 目代貴之, 追泉里実, 菅野太郎

日本防菌防黴学会年次大会要旨集　41st　2014
過酸化水素光分解殺菌技術を応用した新規義歯先浄システムが床用レジンに及ぼす影響

原田章生, 中原達郎, 山田康友, 小田島優, 稲垣亮一, 菅野太郎, 佐々木啓一

日本補綴歯科学会学術大会プログラム・抄録集　122nd　178　2013/05/01

ISSN： 1883-4426
電気分解で生成された酸性電解水中に存在する水酸化ラジカルは殺菌活性に寄与するか?

目代貴之, 中村圭祐, 菅野太郎, 庭野吉己

日本防菌防黴学会年次大会要旨集　40th　2013
Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats (vol 37, pg 329, 2012)

Yasutomo Yamada, Takayuki Mokudai, Keisuke Nakamura, Eisei Hayashi, Yoshiko Kawana, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

JOURNAL OF TOXICOLOGICAL SCIENCES　37　(5)　1091-1091　2012/10

ISSN： 0388-1350

eISSN： 1880-3989
過酸化水素光分解殺菌法に対する微生物の抵抗性とカタラーゼ活性の関連性

中村圭祐, 菅野太郎, 目代貴之, 林栄成, 猪飼紘代, 佐々木啓一, 庭野吉己

日本歯科医師会雑誌　65　(5)　615-615　2012/08
Publisher: (公社)日本歯科医師会
ISSN： 0047-1763
過酸化水素光分解を応用したラジカル殺菌技術のin vivo殺菌活性および安全性評価

庭野吉己, 林栄成, 山田康友, 目代貴之, 中村圭祐, 菅野太郎, 佐々木啓一

日本防菌防黴学会年次大会要旨集　39th　2012
過酸化水素光分解を利用した新規歯科治療器のラット口腔粘膜および創傷皮膚への局所応用における急性の毒性学的評価

山田康友, 目代貴之, 中村圭祐, 林栄成, 菅野太郎, 佐々木啓一, 庭野吉己

日本酸化ストレス学会学術集会プログラム・抄録集　65th　2012
過酸化水素光分解を応用した新しい殺菌システムの黄色ブドウ球菌に対するin vitroおよびin vivo抗菌活性

林栄成, 目代貴之, 山田康友, 中村圭祐, 菅野太郎, 佐々木啓一, 庭野吉己

日本酸化ストレス学会学術集会プログラム・抄録集　65th　2012
Comparison of different analytical methods for determining singlet oxygen photogenerated from rose bengal

Kirika Ishiyama, Keisuke Nakamura, Hiroyo Ikai, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano, Masahiro Kohno

Interface Oral Health Science 2011　89-91　2012/01/01

DOI： 10.1007/978-4-431-54070-0_15 　
Corrosion resistance of dental metals to hydroxyl radical generated by photolysis of H<inf>2</inf>O<inf>2</inf>

Yasutomo Yamada, Keisuke Nakamura, Yukyo Takada, Takayuki Mokudai, Hiroyo Ikai, Ryoichi Inagaki, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano, Masahiro Kohno

Interface Oral Health Science 2011　240-242　2012/01/01

DOI： 10.1007/978-4-431-54070-0_68
Bactericidal effect of hydroxyl radical generated by photolysis of hydrogen peroxide

Hiroyo Ikai, Keisuke Nakamura, Midori Shirato, Taro Kanno, Atsuo Iwasawa, Yoshimi Niwano, Keiichi Sasaki, Masahiro Kohno

Interface Oral Health Science 2011　86-88　2012/01/01

DOI： 10.1007/978-4-431-54070-0_14 　
Booster effect of thermal energy on bactericidal action of hydroxyl radical generated by photolysis of H<inf>2</inf>O<inf>2</inf>

Midori Shirato, Hiroyo Ikai, Keisuke Nakamura, Eisei Hayashi, Taro Kanno, Keiichi Sasaki, Masahiro Kohno, Yoshimi Niwano

Interface Oral Health Science 2011　150-152　2012/01/01

DOI： 10.1007/978-4-431-54070-0_38
ヒドロキシルラジカルが歯科用金属の耐食性に及ぼす影響

山田康友, 中村圭祐, 高田雄京, 目代貴之, 猪飼紘代, 稲垣亮一, 菅野太郎, 佐々木啓一, 庭野吉己, 河野雅弘

日本酸化ストレス学会学術集会プログラム・抄録集　64th　2011
過酸化水素光分解殺菌法における微生物の反応動態解析

林栄成, 中村圭祐, 菅野太郎, 目代貴之, 岩沢篤朗, 河野雅弘, 庭野吉己

日本酸化ストレス学会学術集会プログラム・抄録集　64th　2011
A Case of Perio-Implant-Prosthesis to Severe Generalized Chronic Periodontitis Patient

KANNO T

1　(118)　260-260　2010/08/16
Denture Plaque Removal Efficacy of Denture Cleansing System Utilizing Radical Disinfection Ability of Low Concentration H_2O_2 Activated by Visible Radiation

KANNO T, MOKUDAI T, HAYASHI E, IKAI H, NAKAMURA K, KUDOU A, KOHNO M, SASAKI K

日本補綴歯科学会誌. 特別号, 社団法人日本補綴歯科学会学術大会プログラム・抄録集 = Program and abstracts, the ... scientific meeting of Japan Prosthodontic Society　1　(118)　110-110　2010/08/16
ESRスピントラップ法を用いたラジカル定量の潜在的問題

佐藤恵美子, 中村圭祐, 菅野太郎, 猪飼紘代, 目代貴之, 庭野吉己, 小澤俊彦, 河野雅弘

日本酸化ストレス学会学術集会プログラム・抄録集　63rd　128　2010/06/24
ESRオキシメトリー法を応用した微生物および動物細胞の新しいカタラーゼ活性測定法

中村圭祐, 中村圭祐, 菅野太郎, 目代貴之, 岩沢篤郎, 岩沢篤郎, 庭野吉己, 河野雅弘

日本酸化ストレス学会学術集会プログラム・抄録集　63rd　2010
化学発光における末梢血好中球と口腔内好中球の細胞応答の違い

八重柏典子, 佐藤恵美子, 中村圭祐, 猪飼紘代, 林栄成, 菅野太郎, 河野雅弘

日本酸化ストレス学会学術集会プログラム・抄録集　62nd　117　2009/06/11
光励起された電解水および過酸化水素の殺菌効果

菅野太郎, 古田美香, 目代貴之, 中村圭祐, 岩沢篤朗, 河野雅弘

日本口腔機能水学会誌　10　(1)　45-46　2009/03
Publisher: 日本口腔機能水学会
低濃度過酸化水素に405nm可視光を照射することにより生成したヒドロキシルラジカルの殺菌効果

中村圭祐, 目代貴之, 菅野太郎, 林栄成, 猪飼紘代, 河野雅弘, 岩沢篤郎

日本防菌防黴学会年次大会要旨集　36th　2009
Denture Plaque Removal Efficacy of Denture Cleansing Device Utilizing Radical Ssterilization Ability of Activated Low Hypodense Hydrogen Peroxide

KANNO T, HAYASHI E, IKAI H, NAKAMURA K, MOKUDAI T, KUDOU A, KOHNO M, SASAKI K

日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society　52　(117)　2008/06/06
Radical Sterilization Properties of Hydrogen Peroxide Activated by LED (386nm) Irradiation for Candida Albicans

IKAI H, KANNO T, NAKAMURA K, HAYASHI E, MOKUDAI T, IWASAWA A, KUDOU A, KOHNO M

日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society　52　(117)　2008/06/06
New Irradiation System for Clinical Dental Treatment Advanced Using Low Density Hydrogen Peroxide and Laser Diode

IKAI H, KANNO T, HAYASHI E, NAKAMURA K, MOKUDAI T, KUDOU A, IWASAWA A, KOHNO M

日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society　52　(117)　2008/06/06
Plaque Removal by the Ultrasound Device Utilized Active Oxygen and Free Radical : Part 4

HAYASHI E, KANNO T, IKAI H, MOKUDAI T, KIMURA K, KOUNO M

日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society　52　(117)　195-195　2008/06/06
電解機能水と特定周波数の超音波を併用したプラーク除去法

林栄成, 菅野太郎, 猪飼紘代, 目代貴之, 中村圭祐, 河野雅弘

日本口腔機能水学会誌　9　(1)　36-36　2008/03
Publisher: 日本口腔機能水学会
電解機能水と特定周波数の超音波を併用したプラーク除去法

林栄成, 菅野太郎, 猪飼紘代, 目代貴之, 中村圭祐, 河野雅弘

口腔機水誌　9　(1)　36-36　2008/03
Publisher: 日本口腔機能水学会
過酸化水素が有するラジカル殺菌能を高度利用した義歯洗浄技術

目代貴之, 菅野太郎, 林栄成, 猪飼紘代, 工藤朗人, 岩沢篤郎, 岩沢篤郎, 河野雅弘

日本防菌防黴学会年次大会要旨集　35th　2008
活性酸素・フリーラジカルを応用した化学的なプラーク除去第１報

猪飼紘代, 菅野太郎, 目代貴之, 林栄成, 中村圭祐, 河野雅弘, 木村幸平

日本補綴歯科学会雑誌　51　(116回特別)　155-155　2007/05
Publisher: (公社)日本補綴歯科学会
ISSN： 0389-5386

eISSN： 1883-177X
活性酸素・フリーラジカルを応用した化学的なプラーク除去第2報

林栄成, 菅野太郎, 目代貴之, 猪飼紘代, 中村圭祐, 河野雅弘, 木村幸平

日本補綴歯科学会雑誌　51　(116回特別)　156-156　2007/05
Publisher: (公社)日本補綴歯科学会
ISSN： 0389-5386

eISSN： 1883-177X
活性酸素・フリーラジカルを応用した化学的なプラーク除去第１報

猪飼紘代, 菅野太郎, 目代貴之, 林栄成, 中村圭祐, 河野雅弘, 木村幸平

日本補綴歯科学会雑誌　51　115　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去第2報

林栄成, 菅野太郎, 目代貴之, 猪飼紘代, 中村圭祐, 河野雅弘, 木村幸平

日本補綴歯科学会雑誌　51　116　2007
歯周病による咬合崩壊へのチームアプローチとインプラント矯正

船津三奈代, 菅原準二, 弘岡秀明, 菅野太郎, 長坂浩, 川村仁

日本歯科評論　67　(7)　81-88　2007
部分歯列の臨床 -Introduction-

菅野太郎, 弘岡秀明

ザ・クインテセンス　26　(10)　96-108　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去-第3報-

林栄成, 菅野太郎, 目代貴之, 猪飼紘代, 中村圭祐, 木村幸平, 河野雅弘

日本補綴歯科学会雑誌　22　2007
歯周病による咬合崩壊へのチームアプローチとインプラント矯正

船津三奈代, 菅原準二, 弘岡秀明, 菅野太郎, 長坂浩, 川村仁

日本歯科評論　67　(7)　81-88　2007
Topography, microhardness, and precision of fit on ready-made zirconia abutment before/after sintering process

Taro Kanno, Percy Milleding, Ann Wennerberg

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH　9　(3)　156-165　2007

DOI： 10.1111/j.1708-8208.2007.00044.x 　

ISSN： 1523-0899
Partial Dental Arch Concept -Introduction-

菅野太郎, 弘岡秀明

the Quintessence　26　(10)　96-108　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去-第3報-

林栄成, 菅野太郎, 目代貴之, 猪飼紘代, 中村圭祐, 木村幸平, 河野雅弘

日本補綴歯科学会雑誌　22　2007
A review of the shortened dental arch concept focusing on the work by the Kayser/Nijmegen group

T. Kanno, G. E. Carlsson

JOURNAL OF ORAL REHABILITATION　33　(11)　850-862　2006/11

DOI： 10.1111/j.1365-2842.2006.01625.x 　

ISSN： 0305-182X
[A review of clinical follow-up studies focusing on pretreatment conditions of abutment and clinical examination parameters] (Nihon Hotetsu Shika Gakkai Zasshi)

Ikai Hiroyo, Kanno Taro, Kimura Kohei

Nihon Hotetsu Shika Gakkai Zasshi　50　(2)　245-255　2006
はたして過剰な咬合力は歯科用インプラントの失敗を招くのか？ -Scandinavian Consensus- (日本実験力学会誌)

菅野太郎, 中村圭祐, 猪飼紘代, 林栄成

日本実験力学会誌　6　(2)　82-87　2006
[A review of clinical follow-up studies focusing on pretreatment conditions of abutment and clinical examination parameters] (Nihon Hotetsu Shika Gakkai Zasshi)

Ikai Hiroyo, Kanno Taro, Kimura Kohei

Nihon Hotetsu Shika Gakkai Zasshi　50　(2)　245-255　2006
Does the excessive occlusal load cause the failure of the dental implant? -Scandinavian Consensus- (The Japanese Society for Experimental Mechanics)

Kanno Taro, Nakamura Keisuke, Ikai Hiroyo, Hayashi Eisei

The Japanese Society for Experimental Mechanics　6　(2)　82-87　2006
6. アルジネート印象の採得方法と保管方法の相違による咬合再現性の臨床的評価(第44回東北大学歯学会講演抄録)

片岡展夫, 菅野太郎, 猪飼紘代, 中村圭祐, 三宅理史, 木村幸平, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野

東北大学歯学雑誌 = Tohoku University dental journal　23　(1)　37-37　2004/06/30

ISSN： 0287-3915
コーヌスクローネと磁性アタッチメントの境界 (日本補綴歯科学会雑誌)

木村幸平, 菅野太郎

日本補綴歯科学会雑誌　48　(2)　154-158　2004
Is It Necessary to Replace the Molar Regions for Dentition Maintenance? : A Review of Literature : Kayser's Shortened Dental Arch Concept

KANNO Taro, HIROOKA Hideaki, KIMURA Kohei

Journal of Prosthodontic Research　48　(3)　441-456　2004
Publisher: Japan Prosthodontic Society
DOI： 10.2186/jjps.48.441 　

ISSN： 0389-5386

More details Close

Purpose: There has been no systematic clinical study of the scientific evidence of replacing missing teeth. We suggest that the number of teeth being replaced should not only be decided from morphologic and dynamic viewpoints, but also from a diverse viewpoint. Study Selection: To prove the suggestion, a series of research of Kayser (Netherlands) advocating the Shortened Dental Arch (SDA) Concept is reviewed. Results: Kayser et al. reported that there were no significant clinical differences between a SDA of 3-5 occlusal units (one molar unit is considered to be equivalent to two occlusal units) and a complete dental arch in the migration of teeth, masticatory ability, TMD, periodontal support, and oral comfort. Therefore, it was proposed that the anterior and premolar regions should always get the best quality care throughout life. In long-term longitudinal clinical studies, the SDA group indicated minor changes of the criteria on occlusal stability, however, the occlusal relationship remained stable in the evaluation period. As a result, the studies suggested that the changes were adaptation leading to a new equilibrium and SDA did not result in occlusal collapse. Conclusions: From this review of literature, it was revealed that the SDA Concept might be a dental therapy validated by the scientific evidence. Consequently, a strategy to reduce complex restorative treatment in the molar area may be accepted.
科学的根拠に基づくこれからの歯周病治療の潮流 -神奈川歯科大学同窓会学術講演会より- (歯界展望)

菅野太郎, 中村圭祐

歯界展望　104　(6)　1295-1299　2004
The Boundary between the Cone-crown Telescope System and the Magnetic Attachment (The Journal of Japan Prosthodontic Society)

Kimura Kohei, Kanno Taro

The Journal of Japan Prosthodontic Society　48　(2)　154-158　2004
Is it necessary to replace the molar regions for dentition maintenance? -A review of literature: Käyser's shortened dental arch concept- (The journal of Japan Prosthodontic Society)

Kanno Taro, Hirooka, Hideaki, Kimura Kohei

The journal of Japan Prosthodontic Society　48　(3)　441-456　2004
Publisher: Japan Prosthodontic Society
DOI： 10.2186/jjps.48.441 　

ISSN： 0389-5386

More details Close

Purpose: There has been no systematic clinical study of the scientific evidence of replacing missing teeth. We suggest that the number of teeth being replaced should not only be decided from morphologic and dynamic viewpoints, but also from a diverse viewpoint. Study Selection: To prove the suggestion, a series of research of Kayser (Netherlands) advocating the Shortened Dental Arch (SDA) Concept is reviewed. Results: Kayser et al. reported that there were no significant clinical differences between a SDA of 3-5 occlusal units (one molar unit is considered to be equivalent to two occlusal units) and a complete dental arch in the migration of teeth, masticatory ability, TMD, periodontal support, and oral comfort. Therefore, it was proposed that the anterior and premolar regions should always get the best quality care throughout life. In long-term longitudinal clinical studies, the SDA group indicated minor changes of the criteria on occlusal stability, however, the occlusal relationship remained stable in the evaluation period. As a result, the studies suggested that the changes were adaptation leading to a new equilibrium and SDA did not result in occlusal collapse. Conclusions: From this review of literature, it was revealed that the SDA Concept might be a dental therapy validated by the scientific evidence. Consequently, a strategy to reduce complex restorative treatment in the molar area may be accepted.
The modality of the periodontal therapy based on the evidence. - from the lecture of the alumni association of Kanagawa Dental Univ.- (Dental Outlook)

Kanno Taro, Nakamura Keisuke

Dental Outlook　104　(6)　1295-1299　2004
4. 咬合採得における再現性について : 採得方法のトレーニング前後および採得材料間の相違(第43回東北大学歯学会講演抄録)

片岡展夫, 菅野太郎, 猪飼紘代, 中村圭祐, 三宅埋史, 木村幸平, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野, 東北大学大学院歯学研究科口腔修復学講座咬合機能再建学分野

東北大学歯学雑誌 = Tohoku University dental journal　22　(2)　127-127　2003/12/30

ISSN： 0287-3915
インプラント治療における生物学 -Lindhe教授講演会より- (歯界展望)

菅野太郎, 中村圭祐

歯界展望　101　(5)　1141-1145　2003
The biology of implant therapy - from the lecture of Prof. Lindhe.- (Dental Outlook)

Kanno Taro, Nakamura Keisuke

Dental Outlook　101　(5)　1141-1145　2003
エムドゲインによる生物学的コンセプトに基づいた組織再生法？ -エムドゲイン療法の適応症- その１ (ザ・クインテッセンス)

弘岡秀明, 菅野太郎

ザ・クインテッセンス　21　(4)　169-177　2002
エムドゲインによる生物学的コンセプトに基づいた組織再生法？ -エムドゲイン療法の適応症- その２ (ザ・クインテッセンス)

弘岡秀明, 菅野太郎

ザ・クインテッセンス　21　(5)　99-118　2002
The tissue regenerative therapy by EMDOGAIN based on the biological concept V. The indication of EMDGAIN therapy - 1 (The Quintessence)

Hirooka Hideaki, Kanno Taro

The Quintessence　21　(4)　169-177　2002
The tissue regenerative therapy by EMDOGAIN based on the biological concept V. The indication of EMDOGAIN therapy - 2 (The Quintessence)

Hirooka Hideaki, Kanno Taro

The Quintessence　21　(5)　99-118　2002
磁性ステンレス鋼の歯科鋳造に関する基礎的検討第3報機械的性質ならびに適合精度

相田光治郎, 羽岡克規, 菅野太郎, 依田正信, 木村幸平, 高田雄京, 奥野攻, 中山孝文

日本磁気歯科学会雑誌　10　(1)　71-71　2001/10/01
Publisher: 日本磁気歯科学会
ISSN： 0918-9629
白金鉄系磁石合金のクラウンブリッジへの応用磁性ステンレス鋼との接触腐食について

羽岡克規, 菅野太郎, 木村幸平, 高田雄京, 奥野攻

日本磁気歯科学会雑誌　9　(1)　34-35　2000/10/01
Publisher: 日本磁気歯科学会
ISSN： 0918-9629
磁性ステンレス鋼の歯科鋳造に関する基礎的検討磁気特性と吸引力

相田光治郎, 羽岡克規, 菅野太郎, 依田正信, 木村幸平

日本磁気歯科学会雑誌　9　(1)　11-16　2000
歯科鋳造による白金鉄系磁石合金と磁性ステンレス鋼の可撤式クラウン・ブリッジへの応用 (QDT)

菅野太郎, 羽岡克規, 相田光治郎, 木村幸平, 奥野攻, 中山孝文

QDT　25　(3)　19-26　2000
Application of the iron-platinum magnetic ally and magnetic stainless steel to the removable crown & bridge by dental casting. (Quintessence of Dental Technology)

Kanno Taro, Haoka Katunori Aida Kojiro Kimura, Kohei Okuno, Osamu, Nakayama Takafumi

Quintessence of Dental Technology　25　(3)　19-26　2000
Corrosion Resistance of the Pt-Fe-Nb Magnets for Dental-casting

Katsunori Haoka, Taro Kanno, Yukyo Takada, Kohei Kimura, Osamu Okuno

Dental Materials Journal　19　(3)　270-282　2000
Publisher: Japanese Society for Dental Materials and Devices
DOI： 10.4012/dmj.19.270 　

ISSN： 0287-4547
磁性ステンレス鋼の加熱と耐食性について

高田雄京, 飯島一法, 奥野攻, 羽岡克規, 相田光治郎, 菅野太郎, 木村幸平, 中山孝文

日本磁気歯科学会雑誌　8　(1)　84-84　1999/10
Publisher: 日本磁気歯科学会
ISSN： 0918-9629
磁性ステンレス鋼の歯科鋳造に関する基礎的検討？埋没材について？

相田光治郎, 羽岡克規, 菅野太郎, 木村幸平, 高田雄京飯島一法奥野, 攻, 中山孝文

日本磁気歯科学会雑誌　8　(1)　28-34　1999
Dental Casting of Magnetic Stainless Steel.

Aida Kojiro, Haoka Katunori, Kanno, Taro Kimura Kohei, Takada Yukyo, Iigima Kazunori, Okuno Osamu, Nakayama Takafumi

The Japanese Society of Magnetic Applications in Dentistry　8　(1)　28-34　1999
白金鉄磁石のメビウス症候群による口唇閉鎖不全への応用の試み磁性インプラントの吸引力について

羽岡克規, 菅野太郎, 木村幸平, 菊地聖史, 高田雄京, 奥野攻, 中山孝文, 山田勲, 三次正春

日本磁気歯科学会雑誌　7　(1)　66-67　1998/10
Publisher: 日本磁気歯科学会
ISSN： 0918-9629
白金鉄系磁石合金鋳造体に及ぼすSiおよびNbの添加効果

菅野太郎, 中山孝文, 木村幸平, 奥野攻

歯科材料・器械　17　(1)　54-61　1998

DOI： 10.18939/jjdm.17.1_54 　
Basic Investigation of Fe-Pt-Nb Magnetic Alloys to Removable Crowns and Bridges by Casting

KANNO Taro, NAKAYAMA Takafumi, OKUNO Osamu, KIMURA Kohei

Journal of Prosthodontic Research　42　(3)　424-430　1998
Publisher: Japan Prosthodontic Society
DOI： 10.2186/jjps.42.424 　

ISSN： 0389-5386

More details Close

The purpose of this study was to examine effects of magnetizing, methods on attractive forces in disk-type model and crown-type model which consisted of two kinds of Fe-Pt magnetic alloys (Fe-39.5Pt-0.75 Nb (mole%), Fe-39.5 Pt-0.65 Nb-0.1Si (mole%)). In addition the surface roughness and adaptability of the inner surfaces were examined in the crown-type model. The results were as follows: 1. Surface roughness (crown-type samples) There was no significant difference between the alloys. As for the alloys, surface roughness was greater than that of the metal model. 2. Adaptability (crown-type samples) The adaptability of the crown-type was loose. In order to keep the frictional forces as small as possible, the expansion of the investment was intentionally increased by the adjustment of the L/P ratio. 3. Attractive forces 1) Disk-type samples The attractive force of the disk-type was large when magnetized at four-poles on a plane and the attractive force of a sample was 734 gf on the average. 2) Crown-type samples The attractive force observed with crown-type (magnetized along the crown axis, Fe-39.5 Pt-0.65 Nb-0.1 Si (mole%)) showed 536 gf on the average. This value was sufficient for retaining removable crowns and bridges.
Effects of Si and Nb on Fe-Pt Magnetic Casting Alloys.

Kanno Taro, Nakayama Takafumi Kimura, Kohei Okuno Osamu

The Journal of the Japanese Society for Dental Materials and Devices　17　(1)　54-61　1998

DOI： 10.18939/jjdm.17.1_54 　
Basic Investigation Of Fe-Pt-Nb Magnetic Alloys to Removable Crowns and Bridges by Casting

Kanno Taro, Nakayama, Takafumi, Okuno, Osamu, Kimura Kohei

The Journal of Japan Prosthodontic Society　42　(3)　424-430　1998
Publisher: Japan Prosthodontic Society
DOI： 10.2186/jjps.42.424 　

ISSN： 0389-5386

More details Close

The purpose of this study was to examine effects of magnetizing, methods on attractive forces in disk-type model and crown-type model which consisted of two kinds of Fe-Pt magnetic alloys (Fe-39.5Pt-0.75 Nb (mole%), Fe-39.5 Pt-0.65 Nb-0.1Si (mole%)). In addition the surface roughness and adaptability of the inner surfaces were examined in the crown-type model. The results were as follows: 1. Surface roughness (crown-type samples) There was no significant difference between the alloys. As for the alloys, surface roughness was greater than that of the metal model. 2. Adaptability (crown-type samples) The adaptability of the crown-type was loose. In order to keep the frictional forces as small as possible, the expansion of the investment was intentionally increased by the adjustment of the L/P ratio. 3. Attractive forces 1) Disk-type samples The attractive force of the disk-type was large when magnetized at four-poles on a plane and the attractive force of a sample was 734 gf on the average. 2) Crown-type samples The attractive force observed with crown-type (magnetized along the crown axis, Fe-39.5 Pt-0.65 Nb-0.1 Si (mole%)) showed 536 gf on the average. This value was sufficient for retaining removable crowns and bridges.
Magnetic Properties of hard magnetic Fe-Pt alloys in dental casts.

Nakayama Takafumi, Watanabe, Masato Honma, Motofumi, Kanno, Taro Kimura, Kohei Okuno Osamu

The Magnetic Society of Japan　21　(4)　377-380　1997
Publisher: The Magnetics Society of Japan
DOI： 10.3379/jmsjmag.21.377 　

ISSN： 0285-0192

More details Close

Application of a hard magnetic alloy, Fe-39.5%Pt-0.75% Nb, to dental parts such as crowns and bridges, was investigated. The material has excellent magnetic properties and corrosion resistance. All of the samples were produced by the dental casting method, and the optimum conditions for producing good hard magnets for crowns and bridges were determined. The results obtained were as follows: Casting by means of alumina and magnesia investment showed good results as regards the surface roughness of alloys. The alloys made by dental casting showed energy products as high as 15 MGOe. The attractive force was in the range from 600 to 700 gf, which is required in applications for removable dental parts.
歯科鋳造による白金鉄磁石合金のクラウン・ブリッジへの応用

菅野太郎依田正信木村幸平高田雄京, 飯島一法, 奥野攻, 中山孝文

日本磁気歯科学会雑誌　5　(1)　48-66　1996
An Application of Fe-Pt-Nb Magnet to Crown and Bridje Prosthodontics.

Kanno Taro, Yoda, Masanobu Kimura Kohei, Takada Yukyo, Iijima Kazunori, Okuno Osamu

The Japanese Society of Magnetic Applications in Dentistry　5　(1)　48-66　1996

Show all ︎Show first 5

Books and Other Publications 2

オクルージョン＆クリニカルプラクティス

医歯薬出版株式会社　2007
Occlusion and Clinical Practice. An Evidence-Based Approach.

Ishiyaku Publishers　2007

Presentations 88

高透光性歯科用ジルコニアの微細構造評価

宍戸駿一, 原田章生, 稲垣亮一, 菅野太郎, 江草宏

日本補綴歯科学会東北・北海道支部学術大会　2019/10
歯周病原因菌によって汚染されたチタン表面の清浄化技術の開発：過酸化水素光分解で生成する水酸化ラジカルの応用.

白土翠, 中村圭祐, 天雲太一, 菅野太郎, 佐々木啓一, 庭野吉己

第46回日本防菌防黴学会年次大会　2019/09
医師主導治験におけるラジカル殺菌歯周病治療器の臨床効果の検証：無作為化比較試験

佐々木啓一, 菅野太郎, 中村圭祐, 石山希里香, 山田康友, 白土翠, 庭野吉己, 萱場千恵, 池田浩治, 高木愛理, 山口拓洋

第62回春季日本歯周病学会学術大会　2019/05
プロタミンを付与したリン酸カルシウム系遺伝子導入剤の抗菌作用

天雲太一, 中村圭祐, 白土翠, 菅野太郎, 佐々木啓一

第45回日本防菌防黴学会年次大会　2018/11
カフェイン酸に対するUV-A照射で得られる殺菌作用と口腔粘膜刺激性の評価

中村圭祐, 天雲太一, 目代貴之, 白土翠, 石山希里香, 菅野太郎, 佐々木啓一, 庭野吉己

第45回日本防菌防黴学会年次大会　2018/11
Streptococcus mutansバイオフィルムが引き起こす歯質脱灰に対する過酸化水素光分解殺菌技術の効果

白土翠, 中村圭祐, 天雲太一, 菅野太郎, 庭野吉己

第45回日本防菌防黴学会年次大会　2018/11
カテキンの光酸化を介した殺菌活性と光酸化機序の解明―その2―.

宍戸駿一, 宮野怜, 中島琢自, 松尾洋孝, 岩月正人, 中村圭祐, 菅野太郎, 江草宏, 庭野吉己

第45回日本防菌防黴学会年次大会　2018/11
遺伝子導入剤を含有したナノハイドロキシアパタイト-コラーゲンscaffoldの開発

天雲太一, 中村圭祐, 菅野太郎, 佐々木啓一

第61回春季日本歯周病学会学術大会　2018/06
Gene transfection in vivo with bone morphogenetic protein-2 encoding DNA-functionalized calcium phosphate nanoparticle-loaded collagen scaffolds.

Tenkumo T, Saenz JRV, Nakamura K, Shimizu Y, Sokolova V, Epple M, Kamano Y, Egusa H, Sugaya T, Sasaki K

International Symposium for Multimodal Research and Education in IOHS-Liaison 2018　2018/01
Reconditioning of biofilm-contaminated titanium surface for osteoblast proliferation by hydroxyl radicals generated via H2O2 photolysis.

Nakamura K, Shirato M, Tenkumo T, Kanno T, Westerlund A, Örtengren U, Sasaki K, Niwano Y

International Symposium for Multimodal Research and Education in IOHS-Liaison 2018　2018/01
Comparison of antimicrobial activity of hydrogen peroxide photolysis against Streptococcus mutans biofilm with photodynamic therapy.

Shirato M, Nakamura K, Kanno T, Lingström P, Niwano Y, rtengren U

CED-IADR/NOF Oral Health Research Congress　2017/10
Anti-biofilm effect of hydroxyl radicals generated in UVA-irradiated caffeic acid

Nakamura K, Shirato M, Kanno T, Lingström P, Örtengren U, Niwano Y

CED-IADR/NOF Oral Health Research Congress　2017/10
齲蝕原因菌（Streptococcus mutans）のバイオフィルムに対する長波長紫外線照射の殺菌作用.

中村圭祐, 白土翠, 菅野太郎, 庭野吉己

日本防菌防黴学会第44回年次大会　2017/09
カテキンの光酸化を介した殺菌活性と光酸化機序の解明

宍戸駿一, 宮野怜, 中島琢自, 佐藤恵美子, 中村圭祐, 菅野太郎, 江草宏, 庭野吉己

日本防菌防黴学会第44回年次大会　2017/09
Scandinavian Occlusionを基礎とした咬合の再考 ”はたしてオクルージョンに何処までエビデンスがあるか？”

2008 3rd Wednesday 特別講演会　2008
電解機能水と特定周波数の超音波を併用したプラーク除去法

日本口腔機能水学会　2008
Scandinavian Occlusionを基礎とした咬合の再考 ”はたしてオクルージョンに何処までエビデンスがあるか？”

2008 3rd Wednesday 特別講演会　2008
電解機能水と特定周波数の超音波を併用したプラーク除去法

日本口腔機能水学会　2008
スカンジナビアン・オクルージョンのコンセンサス ―北欧では“咬合”をどう考え、どう対処されているかー

関東矯正会特別セミナー2007　2007
スカンジナビア咬合のコンセンサス理想と臨床の間を科学的根拠から検証する

2007SSG特別講演会　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去第１報

日本補綴歯科学会第116回学術大会　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去第2報

日本補綴歯科学会第116回学術大会　2007
Radical Sterilization Properties of Hydrogen Peroxide Activated by LED(386nm) Irradiation for Oral Bacterium. A Pilot Study

The 2nd Joint Meeting of the Japan Prosthodontic Society and the Greater New York Academy of Prosthodontics　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去-第3報-

日本補綴歯科学会北海道・東北支部会　2007
スカンジナビアン・オクルージョンのコンセンサス ―北欧では“咬合”をどう考え、どう対処されているかー

関東矯正会特別セミナー2007　2007
スカンジナビア咬合のコンセンサス理想と臨床の間を科学的根拠から検証する

2007SSG特別講演会　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去第１報

日本補綴歯科学会第116回学術大会　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去第2報

日本補綴歯科学会第116回学術大会　2007
Radical Sterilization Properties of Hydrogen Peroxide Activated by LED(386nm) Irradiation for Oral Bacterium. A Pilot Study

The 2nd Joint Meeting of the Japan Prosthodontic Society and the Greater New York Academy of Prosthodontics　2007
活性酸素・フリーラジカルを応用した化学的なプラーク除去-第3報-

日本補綴歯科学会北海道・東北支部会　2007
スカンジナビアンオクルージョンのコンセンサスとPerio-Implant-Proshesis(P.I.P)

仙台臨床研修会　2006
スカンジナビアンオクルージョンのコンセンサス

第３回Journal Club　2006
はたして過剰な咬合力は歯科用インプラントの失敗を招くのか？

第６回バイオメカニクス・ワークショップ・仙台　2006
スカンジナビアンオクルージョンのコンセンサスとPerio-Implant-Proshesis(P.I.P)

仙台臨床研修会　2006
スカンジナビアンオクルージョンのコンセンサス

第３回Journal Club　2006
はたして過剰な咬合力は歯科用インプラントの失敗を招くのか？

第６回バイオメカニクス・ワークショップ・仙台　2006
Fixed prosthodontics治療における術後管理システムの構築長期経過症例の後向きコホート研究第1報

日本補綴歯科学会　2005
Fixed prosthodontics治療における術後管理システムの構築〜長期経過症例の後ろ向きコホート研究第２報〜

日本補綴歯科学会　2005
Fixed prosthodontics治療における術後管理システムの構築長期経過症例の後向きコホート研究第1報

日本補綴歯科学会　2005
Fixed prosthodontics治療における術後管理システムの構築〜長期経過症例の後ろ向きコホート研究第２報〜

日本補綴歯科学会　2005
Fixed Prosthodontics治療におけるメインテナンスシステムの構築〜当分野における長期症例の臨床的評価〜

東北大学歯学会　2004
Fixed Prosthodontics治療におけるメインテナンスシステムの構築〜当分野における長期症例の臨床的評価〜

東北大学歯学会　2004
咬合採得における再現性について ―採得方法のトレーニング前後および採得材料間の相違―

東北大学歯学会　2003
咬合採得における再現性について ―採得方法のトレーニング前後および採得材料間の相違―

東北大学歯学会　2003
Grindability of Fe-Pt-Nb Magnetic Alloy and Magnetic Stainless Steel

International congress on dental materials　2002
積分要素法を用いた白金鉄系磁石合金クラウン・ブリッジの最適設計に関する基礎的研究（第二報）

日本磁気歯科学会　2002
Grindability of Fe-Pt-Nb Magnetic Alloy and Magnetic Stainless Steel

International congress on dental materials　2002
積分要素法を用いた白金鉄系磁石合金クラウン・ブリッジの最適設計に関する基礎的研究（第二報）

日本磁気歯科学会　2002
Development of Removable Prosthodontic Appliance Using Fe-Pt Magnetic Alloys.

IADR　2001
歯科用磁性合金の研削性

日本歯科理工学会　2001
白金鉄系磁石合金および磁性ステンレス鋼の研削性

日本磁気歯科学会　2001
Development of Removable Prosthodontic Appliance Using Fe-Pt Magnetic Alloys.

IADR　2001
歯科用磁性合金の研削性

日本歯科理工学会　2001
白金鉄系磁石合金および磁性ステンレス鋼の研削性

日本磁気歯科学会　2001
白金鉄磁石のクラウン・ブリッジへの応用に関する基礎的検討（第四報）白金鉄系磁石合金と磁性ステンレス鋼との接触腐食

日本歯科理工学会　2000
白金鉄磁石のクラウン・ブリッジへの応用に関する基礎的検討（第四報）白金鉄系磁石合金と磁性ステンレス鋼との接触腐食

日本歯科理工学会　2000
Application of Dental Casting Fe-Pt Magnetic Alloy to Removable

Asian Academy of Prosthodontics　1999
磁性ステンレス鋼の歯科鋳造に関する基礎的検討磁気特性と吸引力

日本磁気歯科学会　1999
ハイコレックススリムを用いたネジ式歯根挺出装置の試作

日本磁気歯科学会　1999
白金鉄磁石合金のクラウンブリッジへの応用？磁性ステンレス鋼との接触腐食について？

日本磁気歯科学会　1999
Application of Dental Casting Fe-Pt Magnetic Alloy to Removable

Asian Academy of Prosthodontics　1999
磁性ステンレス鋼の歯科鋳造に関する基礎的検討磁気特性と吸引力

日本磁気歯科学会　1999
ハイコレックススリムを用いたネジ式歯根挺出装置の試作

日本磁気歯科学会　1999
白金鉄磁石合金のクラウンブリッジへの応用？磁性ステンレス鋼との接触腐食について？

日本磁気歯科学会　1999
歯科鋳造による白金鉄磁石合金の可撤式クラウン・ブリッジへの応用第４報

日本補綴歯科学会　1998
白金鉄磁石合金のクラウン・ブリッジへの応用に関する基礎的検討第３報機械的性質および耐食性について

日本歯科理工学会　1998
磁性ステンレス鋼の歯科鋳造に関する基礎的検討第一報埋没材について

日本磁気歯科学会　1998
磁性ステンレス鋼の加熱と耐食性について

日本磁気歯科学会　1998
白金鉄磁石合金の可撤式クラウン・ブリッジへの応用に関する基礎的・臨床的検討

東北大学歯学会　1998
歯科鋳造による白金鉄磁石合金の可撤式クラウン・ブリッジへの応用第４報

日本補綴歯科学会　1998
白金鉄磁石合金のクラウン・ブリッジへの応用に関する基礎的検討第３報機械的性質および耐食性について

日本歯科理工学会　1998
磁性ステンレス鋼の歯科鋳造に関する基礎的検討第一報埋没材について

日本磁気歯科学会　1998
磁性ステンレス鋼の加熱と耐食性について

日本磁気歯科学会　1998
白金鉄磁石合金の可撤式クラウン・ブリッジへの応用に関する基礎的・臨床的検討

東北大学歯学会　1998
歯科鋳造による白金鉄磁石合金の可撤式クラウン・ブリッジへの応用第3報

日本補綴歯科学会　1997
Application of Dental Casting Fe-Pt Magnet to Crowns and Bridg

International Congress on Dental Materials　1997
白金鉄磁石のメビウス症候群による口唇閉鎖不全への応用の試みー磁性インプラントの吸引力についてー

日本磁気歯科学会　1997
歯科鋳造による白金鉄磁石合金の可撤式クラウン・ブリッジへの応用第3報

日本補綴歯科学会　1997
Application of Dental Casting Fe-Pt Magnet to Crowns and Bridg

International Congress on Dental Materials　1997
白金鉄磁石のメビウス症候群による口唇閉鎖不全への応用の試みー磁性インプラントの吸引力についてー

日本磁気歯科学会　1997
歯科鋳造による白金鉄磁石合金の可撤式ブリッジへの応用

日本補綴歯科学会　1996
歯科鋳造による白金鉄磁石合金の可撤式クラウン・ブリッジへの応用第２報

日本補綴歯科学会東北・北海道支部学会　1996
歯科鋳造による白金鉄磁石合金の可撤式ブリッジへの応用

日本補綴歯科学会　1996
歯科鋳造による白金鉄磁石合金の可撤式クラウン・ブリッジへの応用第２報

日本補綴歯科学会東北・北海道支部学会　1996
白金鉄磁石のクラウン・ブリッジへの応用に関する基礎的研究第一報

日本歯科理工学会　1995
歯科鋳造による白金鉄磁石合金のクラウン・ブリッジへの応用

日本磁気歯科学会　1995
白金鉄磁石のクラウン・ブリッジへの応用に関する基礎的研究第一報

日本歯科理工学会　1995
歯科鋳造による白金鉄磁石合金のクラウン・ブリッジへの応用

日本磁気歯科学会　1995

Show all Show first 5

Research Projects 14

Reconditioning of implant surface contaminated by microorganisms using advanced oxidation process

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2022/04/01 - 2025/03/31
Facilitation of wound healing by proanthocyanidin: Application in gerodontology

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2021/04/01 - 2024/03/31
Mechanistic analysis of bone formation via photobiologic reaction triggered by UVA irradiation

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2021/04/01 - 2024/03/31
Improvement of implant osseointegration in osteoporosis patients via modification of intestinal microbiota

Kanno Taro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2019/04 - 2022/03

More details Close

The present study aimed to evaluate the potential effects of proanthocyanidin-rich grape seed extract (GSE) on the healing of bone defects as well as implant osseointegration in ovariectomized (OVX) rats, a model of osteoporosis in postmenopausal women. Female Wistar rats were used. The animals underwent OVX operation. One week after OVX surgery, the second surgery was performed to create calvarial bone defects. In addition, one week after the second surgery, implant surgery was performed to install titanium mini-screws in tibiae. During the healing period, GSE or vehicle (water) was daily administered by oral gavage. OVX tended to impair healing of the defects. However, GSE counteracted the OVX-induced impairment in bone healing. Similarly, GSE increased the implant removal torque and bone-to-implant contact compared to those of the water-administered animals. These findings suggest that oral administration of GSE may be beneficial in dental implant therapy in osteoporosis patients.
Development of surface modification process enabling adhesion with soft tissue for suppressing peri-implantitis

Mizutani Masayoshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2020/03/31

More details Close

Dental health is closely related to quality of life (QOL) improvement, and implant therapy is effective in prosthesis for missing teeth and recovery of QOL. Currently, however, inflammation caused by bacterial infection is a problem in implant therapy. The purpose of this study is to create ideal functional bio-interfaces that have both biocompatibility and anti-bacterial adhesion properties, e.g. hydrophobicity and photocatalytic activity by the simultaneous process of microfabrication and chemical property changes on the material surface with laser processing. In conclusion, functional bio-interfaces for dental implants may be realized by forming grooves suppressing bacterial adhesion and suitable micro-irregularities promoting cell growth.
Establishment of peri-implantitis treatment based on radical disinfection technique

Sasaki Keiichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2015/04/01 - 2018/03/31

More details Close

In this project, in vitro and in vivo tests were performed with an aim of application of radical disinfection technique to treatment for peri-implantitis. In vivo test, where peri-implantitis caused around implants installed in dogs were treated with radical disinfection technique. However, there was no significant difference between the test and control groups. Thus, to find more suitable treatment conditions, in vitro test was additionally performed. The results demonstrated that the radical disinfection technique could recondition the titanium surface that had been previously contaminated by bacteria for subsequent osteoblastic cells. Therefore, future study should focus more on the establishment of treatment condition that enables to acquire re-osseointegration around the implants suffering from peri-implantitis.
Establishment of a basic technology using polyphenols in terms of application to tissue regeneration/protection and tissue engineering

KANNO TARO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2015/04 - 2017/03

More details Close

To assess if proanthocyanidin (PA), which is consisted of catechin oligomers and has a potential to accelerate cell proliferation in vitro, could accelerate tissue regeneration in vivo, the effect of repeated oral administration of PA on liver regeneration in partially hepatectomized rats was examined. As a result, PA did not accelerate liver regeneration in normal and streptozotocin-induced diabetic rats. Given that bioavailability of oral catechin oligomers is low, I then focused on enterobacterial flora and examined the effect of repeated oral administration of PA on equol-producing bacteria in mice. However, no significant effects were found. I will further make a study on isolated organs.
Clinical application of a novel disinfection system based on local administration of low concentration hydroxyl radicals

SASAKI Keiichi, KANNO Taro, HAYASHI Eisei, IKAI Hiroyo, NAKAMURA Keisuke, NIWANO Yoshimi, KOHNO Masahiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2012/04/01 - 2015/03/31

More details Close

Bactericidal effect and biological safety of a novel therapeutic device utilizing a disinfection technique based on photolysis of hydrogen peroxide for the treatment of periodontal disease were evaluated in the present study. In addition, clinical study was conducted to compare the efficacy of the device in the treatment of periodontitis with that of conventional root debridement. In vitro bactericidal tests demonstrated that device exerted high bactericidal effect, whereas in vivo test showed that it did not cause adverse effect on the oral mucosa of rats. In the clinical study, it was demonstrated that the treatment using the device significantly reduced the probing pocket depth 3 months after the treatment than conventional root debridement. Thus, it is suggested that the periodontal treatment using the device may improve the effect of non-surgical periodontal therapy.
Research and development of a novel denture cleaning device utilizing a disinfection technique based on photolysis of hydrogen peroxide

KANNO Taro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04 - 2015/03

More details Close

In the present study, the bactericidal effect and influence on the denture base-resin of denture cleaning technique using a newly developed device based on photolysis of hydrogen peroxide were evaluated. The device consisted of ultrasound cleaning bath and high power LED. Bactericidal test showed that the photolysis of hydrogen peroxide killed Streptococcus mutans with a >5-log reduction of viable counts within 3 min. Regarding the influence of the cleaning technique on the resin material, it was found that the strength and color were affected as the irradiance of LED increased. However, the results suggest that the influence may be acceptable when the LED was used at an irradiance of 10 mW/cm2 even on the assumption of repeated denture cleanings.
青色可視光励起型低濃度過酸化水素ラジカル殺菌技術を応用した次世代義歯洗浄器開発

菅野太郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2010 - 2011

More details Close

われわれはこれまで、日常臨床で用いられるオキシドール(1M;3%)よりも低濃度の過酸化水素に、可視光領域の波長(405nm)のLEDを照射することで、効率的にヒドロキシルラジカル(HO・)を発生させ殺菌を行うという新しい義歯洗浄器を試作し検討を行ってきた. 義歯をこの洗浄器で洗浄する際、HO・は強力な酸化剤であるため、金属や床用レジンといった歯科材料を腐食させるという懸念がある。本年度は、過酸化水素の光分解によって生じるHO・が歯科用金属に及ぼす腐食作用を評価した。金属試料は、12%金銀パラジウム合金、チタン、コバルトクロム合金、ステンレス鋼を用いた。放射照度115mW/cm^2のLEDを光源とし、過酸化水素濃度は1Mとし、金属試料を37℃条件下1週間浸漬し、ICP(誘導結合プラズマ発光分光分析)装置を用いて各元素の溶出イオン量を計測した。その結果、どの歯科用金属においても、1M過酸化水素の光分解によるHO・生成系の腐食作用は、光を照射しない過酸化水素に1週間浸漬した場合よりも低いという結果が得られた。すなわち、本殺菌法を義歯洗浄に応用することの歯科用金属に対する安全性は示された。また、今回、義歯洗浄器自体の改良も行った。義歯を浴槽に入れて洗浄する場合、洗浄液や浴槽も汚染される可能性が高い。したがって、以前試作した放射照度110mW/cm^2のLEDを搭載した洗浄器の改良を行った。浴槽の大きさを大きくし、上下の義歯を同時に洗浄できるようにした。義歯は過酸化水素が入ったプラスチックパックに入れて洗浄し、汚染した洗浄液が浴槽につかない設計とした。
ヒドロキシルラジカルを人工的に生成する新しいラジカル殺菌技術の口腔内領域への応用

佐々木啓一, 菅野太郎, 林栄成, 猪飼紘代, 中村圭祐, 河野雅弘

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2010 - 2011

More details Close

〔目的〕平成23年度は、本ラジカル殺菌技術のin vivoでの抗菌活性及び生体安全性を評価することを目的とした。〔方法〕殺菌活性評価:プレドニゾロン投与により免疫抑制状態にしたラット背部に直径1cmの全層皮膚欠損創を作製し、黄色ブドウ球菌を接種した。創作製の翌日(1日後)および2日後に1 M H_2O_2と青色LED光を2分間創傷部全体に処理した。その2日後に創傷部皮膚を摘出し、培養試験に供した。安全性評価:ラットの口腔粘膜に1 M H_2O_2と青色レーザー光の2分間処理を3日間行い、粘膜組織に対する影響を調べた。加えて、ラット背部に作製した直径1cmの全層皮膚欠損創辺縁部に同様の処理を行い、その後の治癒過程の対する影響を調べた。〔結果〕殺菌活性評価:水だけを処理した対照群に対して1 M H_2O_2+青色LED光処理群では、回収された生菌数は約1/100(2logオーダー)と有意に減少した。水+青色LED光処理群、1 M H_2O_2単独処理群では殺菌効果は認められなかった。安全性評価:1 M H_2O_2+青色レーザー光処理群の口腔粘膜組織像は、水だけを処理した対照群と同様であり、異常所見は認められなかった。ラット皮膚創傷モデルにおいても1 M H_2O_2+青色レーザー光処理群で治癒の遅延はなく、組織学的にも異常所見は認められなかった。以上、in vitroで抗菌活性を発揮する条件で、本殺菌技術のin vivo表在性感染モデルでの抗菌活性を確認するとともに、局所粘膜および損傷皮膚への急性の影響を検討し、安全性に問題がないことを確認した。
唾液由来顆粒球の活性酸素生成能をマーカーとした新規アレルギー診断技術開発

菅野太郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 萌芽研究

Institution: 東北大学

2007 - 2008

More details Close

『研究目的』花粉症患者と健常者において、スギ花粉抗原(SBP)の刺激に応答して口腔内顆粒球と血中顆粒球が活性酸素をどの程度産生するのか?、また、その刺激応答の違いが見られるのか?という疑問に対して、化学発光法とスピンとラップ法(ESR)による検証を行った。さらに細胞の活性状態の1つの指標としてATP測定も行った。『サンプル』花粉症オフシーズンにおける男女19名(自己申告型のアレルギー症状アンケートによる花粉症9名・健常者10名)。サンプル採取の前日20時以降を絶食とし、6時間以上の睡眠をとってもらった。当日は朝食量を統一し(男女差はあり)、歯磨き後9時以降絶飲・絶食とした。昼食前の12時に採血(15ml)、うがい液(60ml)を採取し、1被験者に対してうがい液、血液当日、血液翌日の3サンプルに分け、各サンプルから顆粒球を分離、化学発光測定で1×105 cells/ml(最終濃度7.5×104 cells/ml)、ESRで1×106 cells/ml(7.5×105 cells/ml)を用いて実験を行った。『結果』顆粒球の回収量において、血液翌日で花粉症(+)が(-)より有意に多かった。化学発光値において、血液当日のSBP0.2μg/mlの刺激応答で花粉症(+)が(-)より有意に高かった。ESR測定値において、口腔内顆粒球のSBP0.2μg/mlの刺激比(DMPO-OH値/non)で花粉症(+)が(-)より有意に高かった。ATP値において、血液翌日で花粉症(-)が(+)より有意に高かった。化学発光値とATP値の関係において、口腔内顆粒球の花粉症(-)で強い正の相関関係を示した。『結論』口腔内顆粒球は、アレルギー診断のマーカーになりうる可能性が示唆されたが、産生する活性酸素の相対量に個人差があり、生成量による診断を行うには今後、サンプル数を拡大し精査が必要である。
Construction of the dental attachment manufacturing system made from the Fe-Pt-Nb magnetic alloy by CAD/CAM

KASAHARA Shin, YODA Masanobu, KANNO Taro, OKUNO Osamu, KIKUCHI Masafumi, HAYASHI Eisei

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2002 - 2005

More details Close

New prosthetic appliances composed of outer and inner crowns, each made of Fe-39.5mol%Pt-0.75mol%Nb magnetic alloy and magnetic stainless steel, have been developed. The Fe-Pt-Nb magnet has high energy product almost equivalent to the Sm-Co magnet, and excellent corrosion resistance. Kanno et al. showed the possibility of dental casting of the Fe-Pt magnet alloy. However, there remains a problem that the magnetic properties of the Fe-Pt-Nb magnetic alloy are very sensitive to the thermal history of the casting process. Good grindability is desirable in magnetic alloys for clinical use. Furthermore, if the magnetic alloys could be readily machined by a dental CAD/CAM system, it would be possible to avoid problems related to melting the material, which are inevitable when casting. In this study, the grindability of the cast Fe-Pt-Nb magnetic alloy and the magnetic stainless steel was evaluated and compared with that of conventional dental casting alloys. Furthermore, using the integral element method, the 3-dimensional magnetic field of the outer and inner cap model were analyzed to determine the optimal method for the design and magnetization of removable crown and bridge system made of the Fe-Pt magnet. CONCLUSION 1. There was no significant difference in the grinding rate between the solution treated and aged Fe-Pt-Nb magnetic alloys at 500 m min^<-1>. However, the grinding rate of aged Fe-Pt-Nb magnetic alloy was significantly lower at the higher grinding speeds. 2. It was found that the grinding rate of the aged Fe-Pt-Nb magnetic alloy and the stainless steel were higher than those of conventional casting alloys at lower speed. 3. When the thickness of outer cap top was 1.5mm and the length of outer cap side was 4.0-3.5mm, the optimum attractive force were obtained clinically. 4. The attractive force of model-1 was more excellent than that of model-2. 5. When the occlusal vertical dimension of the molar was low, it was suggested that the thickness of outer cap top was more important than the length of outer cap side in both models.
補綴前処理における磁力を用いた歯根挺出装置の基礎的・臨床的検討

菅野太郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 若手研究(B)

Institution: 東北大学

2001 - 2002

More details Close

1,挺出に関する科学的文献考察による実験デザインの検討挺出に関してこれまでの研究を調査すると,その方法に関してはある程度の客観性と根拠を持った研究がなされているが,必要な挺出力に関する研究はほとんどなく,述べられていたとしても経験的なものばかりで,実際に生物学的組織学的検討は行われておらず,科学的根拠のある結果が得られていないのが現状である.また、磁力を矯正力とした場合,従来のワイヤーやゴムと違って,歯牙が装置に近づくほど矯正力は大きくなるため、磁力をもちいた場合と従来の方法での組織学的相違を検討することが、磁力を用いた挺出の基礎的検討となろう.さらに、挺出時にデンタルプラークの有無によって挺出量、支持骨縁の高さに差が出てくることが示唆されており、まず、プラークの有無と挺出量の関係についての基礎実験を行う必要性があることがわかった。本年度の期間内では、実験に使用する白金鉄系磁石合金に関する論文発表と挺出に必要な矯正力に関する基礎実験デザインの決定までであったが、現在、上記基礎実験を行っている途中であり、その報告は、来年度以降に行う予定である。 2.臨床試験前年度に引き続きに、3名の患者の3歯牙に関して、磁力を用いた試作の歯根挺出装置にて、歯牙の挺出を行った。患者には実験の趣旨・内容、またそれに伴うリスクを十分説明し、この実験に協力する承諾を得た後、処置を行った。結果はすべての歯牙の挺出に成功し、磁力によって歯牙の挺出は可能であることが示唆された。また術者による客観的、患者による主観的評価も、臨床的には問題のないものであった。しかし、前回同様挺出が完了するまでの期間は3・4ヶ月と、従来の挺出装置と比較して長く、症例によっては歯牙形態やスペースに合わせた磁石も必要であった。また,遊離端義歯部での歯牙挺出は、義歯の動揺により困難な場合が多く、挺出を可能とする場合、まず義歯の安定を図ることが大切であることがわかった。

Show all Show first 5

Works 6

口腔内顆粒球の活性酸素応答を利用した生体適合性評価法の開発

2006 - 2008
特定超音波振動を利用した化学的口腔内殺菌方法の開発

2006 - 2008
口腔内顆粒球の活性酸素応答を利用した生体適合性評価法の開発

2006 - 2008
特定超音波振動を利用した化学的口腔内殺菌方法の開発

2006 - 2008
ナノバブルを用いた新しい義歯洗浄器の開発

2006 - 2007
ナノバブルを用いた新しい義歯洗浄器の開発

2006 - 2007

Show all ︎Show first 5