Details of the Researcher

PHOTO

Satoshi Yamaguchi
Section
Graduate School of Dentistry
Job title
Associate Professor
Degree

  • 博士（歯学）（東北大学）

Profile

日本補綴歯科学会専門医・指導医

Research History 5

  • 2023/08 - Present
    Tohoku University Graduate School of Dentistry　Associate Professor

  • 2018/01 - 2023/07
    東北大学病院　講師

  • 2007/04 - 2017/12
    東北大学病院　助教

  • 2006/02 - 2007/03
    東北大学病院　助手

  • 2005/04 - 2006/01
    Tohoku University　Graduate School of Dentistry

Education 2

  • Tohoku University　Graduate School, Division of Dental Research

    - 2005/03/31

  • Tohoku University　Faculty of Dentistry

    - 2001/03/31

Committee Memberships 5

  • 日本補綴歯科学会　代議員

    2019/04 - Present

  • 日本補綴歯科学会　編集委員会委員

    2025/06 - 2027/05

  • 日本補綴歯科学会　研究企画推進委員会幹事

    2019/04 - 2021/03

  • 日本老年歯科医学会　第30回学術大会準備委員長

    2017 - 2019/06

  • 日本補綴歯科学会　第二特命委員会幹事

    2017/04 - 2019/03

Professional Memberships 3

  • International Association for Dental, Oral, and Craniofacial Research

  • JAPANESE SOCIETY OF GERODONTOLOGY

  • JAPAN PROSTHODONTIC SOCIETY

Research Interests 5

  • Dementia

  • 医療画像

  • MRI

  • 顎口腔機能

  • 歯科補綴学

Research Areas 3

  • Other / Other /

  • Life sciences / Community dentistry /

  • Life sciences / Prosthodontics /

Awards 2

  1. 第33回日本老年学会総会（一般社団法人日本老年歯科医学会第34回学術大会） 最優秀合同ポスター賞

    2023/06　現在歯数と歯周炎の交互作用が海馬形態と認知機能に与える影響 ー大迫研究における縦断MRI解析ー

  2. 公益社団法人日本補綴歯科学会第131回学術⼤会 優秀ポスター賞（デンツプライシロナ賞）

    2022/07　公益社団法人日本補綴歯科学会　現在歯数と歯周炎の交互作用が脳形態変化に与える影響：大迫研究における縦断MRI解析

Papers 22

  1. Associations of Dental Health With the Progression of Hippocampal Atrophy in Community-Dwelling Individuals International-journal Peer-reviewed

    Satoshi Yamaguchi, Takahisa Murakami, Michihiro Satoh, Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Kosei Endo, Takako Hiratsuka, Azusa Hara, Yukako Tatsumi, Tomoko Totsune, Kei Asayama, Masahiro Kikuya, Kyoko Nomura, Atsushi Hozawa, Hirohito Metoki, Yutaka Imai, Makoto Watanabe, Takayoshi Ohkubo, Yoshinori Hattori

    Neurology　101　(10)　e1056-e1068　2023/07/05

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1212/wnl.0000000000207579 　

    ISSN： 0028-3878

    eISSN： 1526-632X

    More details Close

    Background and Objectives Although tooth loss and periodontitis have been considered risk factors of Alzheimer disease, recent longitudinal researches have not found a significant association with hippocampal atrophy. Therefore, this study aimed to clarify a longitudinal association between the number of teeth present (NTP) and hippocampal atrophy dependent on the severity of periodontitis in a late middle-aged and older adult population. Methods This study included community-dwelling individuals aged 55 years or older who had no cognitive decline and had undergone brain MRI and oral and systemic data collection twice at 4-year intervals. Hippocampal volumes were obtained from MRIs by automated region-of-interest analysis. The mean periodontal probing depth (PD) was used as a measure of periodontitis. Multiple regression analysis was performed with the annual symmetric percentage change (SPC) of the hippocampal volume as the dependent variable and including an interaction term between NTP and mean PD as the independent variable. The interaction details were examined using the Johnson-Neyman technique and simple slope analysis. The 3-way interaction of NTP, mean PD, and time on hippocampal volume was analyzed using a linear mixed-effects model, and the interaction of NTP and time was examined in subgroups divided by the median mean PD. In all models, dropout bias was adjusted by inverse probability weighting. Results Data of 172 participants were analyzed. The qualitative interaction between NTP and the mean PD was significant for the annual SPC in the left hippocampus. The regression coefficient of the NTP on the annual SPC in the left hippocampus was positive (B= 0.038,p= 0.026) at the low-level mean PD (mean −1 SD) and negative (B= −0.054,p= 0.001) at the high-level mean PD (mean +1 SD). Similar results were obtained in the linear mixed-effects model; the interaction of NTP and time was significant in the higher mean PD group. Discussion In a late middle-aged and older cohort, fewer teeth were associated with a faster rate of left hippocampal atrophy in patients with mild periodontitis, whereas having more teeth was associated with a faster rate of atrophy in those with severe periodontitis. The importance of keeping teeth healthy is suggested.

  2. 「要介護高齢者における補綴診療の目標設定を考える」 臨床倫理の観点から考える要介護高齢者に対する補綴診療 Invited

    山口 哲史

    日本補綴歯科学会誌　15　(3)　288-293　2023/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  3. Expression of matrix metalloproteinase-3 and -10 is up-regulated in the periodontal tissues of aged mice. International-journal Peer-reviewed

    Yoko Kageyama, Megumi Nakamura, Yohei Igari, Satoshi Yamaguchi, Akiko Oguchi, Yasuhiro Murakawa, Yoshinori Hattori, Yasuyuki Sasano

    Journal of periodontal research　57　(4)　733-741　2022/08

    DOI： 10.1111/jre.12996 　

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    OBJECTIVE: The present study was designed to investigate the whole transcriptome of periodontal tissues of both young and aged mice to identify the characteristic up-regulation of protease genes with aging and to localize their translated protein products in the periodontal tissues. BACKGROUND: The metzincin protease superfamily is composed of matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs. Up-regulation of these extracellular matrix-degrading proteases has been implicated in senescence of tissues and organs, including the skin. However, few studies have investigated the expression profiles of these proteases and potential involvement in aging of periodontal tissues. METHODS: Periodontal tissues with the surrounding mandibular bones were collected from 50- and 10-week-old mice. Total RNA was extracted from the periodontal tissue and analyzed by cap analysis of gene expression (CAGE) to identify differentially expressed genes encoding the metzincin proteases. Furthermore, quantitative real-time polymerase chain reaction (qRT-PCR) was performed to validate the CAGE results, and the phenotypic expression of proteases involved in aging was localized via immunohistochemical analysis. RESULTS: The CAGE results showed that the expression levels of MMP-3, -10, and -12 were up-regulated at 50 weeks. Subsequent qRT-PCR analysis showed that the gene expression levels of MMP-3 and -10 were significantly increased with age. MMP-10 immunoreactivity was localized exclusively in the cementum and alveolar bone adjacent to the periodontal ligament and was stronger and broader in aged mice than young mice. MMP-3 immunoreactivity was localized in the periodontal ligaments at both 10 and 50 weeks. CONCLUSION: In the present study, we demonstrated that the expression of MMP-3 and -10 increased with aging and identified their characteristic localizations in aged periodontal tissues.

  4. Statistical parametric mapping of three-dimensional local activity distribution of skeletal muscle using magnetic resonance imaging (MRI). International-journal Peer-reviewed

    Satoshi Yamaguchi, Makoto Watanabe, Yoshinori Hattori

    Scientific reports　11　(1)　4808-4808　2021/02/26

    DOI： 10.1038/s41598-021-84247-0 　

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    Analysis of the internal local activity distribution in human skeletal muscles is important for managing muscle fatigue/pain and dysfunction. However, no method is established for three-dimensional (3D) statistical analysis of features of activity regions common to multiple subjects during voluntary motor tasks. We investigated the characteristics of muscle activity distribution from the data of ten healthy subjects (29 ± 1 year old, 2 women) during voluntary teeth clenching under two different occlusal conditions by applying spatial normalization and statistical parametric mapping (SPM) to analysis of muscle functional magnetic resonance imaging (mfMRI) using increase in transverse relaxation time (T2) of the skeletal muscle induced by exercise. The expansion of areas with significant T2 increase was observed in the masticatory muscles after clenching with molar loss comparing with intact dentition. The muscle activity distribution characteristics common to a group of subjects, i.e., the active region in the temporal muscle ipsilateral to the side with the molar loss and medial pterygoid muscle contralateral to the side with the molar loss, were clarified in 3D by applying spatial normalization and SPM to mfMRI analysis. This method might elucidate the functional distribution within the muscles and the localized muscular activity related to skeletal muscle disorders.

  5. Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles Peer-reviewed

    Megumi NAKAMURA, Naoki AOYAMA, Satoshi YAMAGUCHI, Yasuyuki SASANO

    Biomedical Research　42　(1)　13-21　2021/02/10

    Publisher: Biomedical Research Press

    DOI： 10.2220/biomedres.42.13 　

    ISSN： 0388-6107

    eISSN： 1880-313X

  6. Caregiver‐reported dementia as a predictor of oral health among patients receiving home‐visit dental treatment: A retrospective cohort study International-journal Peer-reviewed

    Satoshi Yamaguchi, Yukari Horigome, Kosei Endo, Moritoshi Komagata, Shinya Komai, Kenichiro Komaki, Hideki Miyata, Kazuhiko Sugano, Setsuko Ito, Shiho Itabashi, Harumi Sato, Minako Okahashi, Sayaka Kishi, Rika Abe, Yoshinori Hattori

    Clinical and Experimental Dental Research　7　(1)　49-55　2021/02

    Publisher: Wiley

    DOI： 10.1002/cre2.333 　

    ISSN： 2057-4347

    eISSN： 2057-4347

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    OBJECTIVE: To assess caregiver-reported dementia as a risk factor for retained roots, an indicator of poor oral hygiene, among patients receiving home-visit dental treatment in Japan. METHODS: The medical records of 231 dentate patients who received home-visit dental treatment (covered by public medical insurance) for more than 2 years were retrospectively analyzed. The number of teeth and retained roots at the initial and final examinations were obtained from the dental charts, and the "change in the number of retained roots from initial to final examination" was determined. The presence or absence of caregiver-reported dementia, diabetes, and osteoporosis, as well as the level of long-term care needed, were used as indicators of general health condition at the initial interview. Multiple regression analyses were conducted in five models that tested the association of independent variables (age, gender, observation period, general health, presence or absence of caregiver-reported dementia at the initial interview) with changes in the number of retained roots. RESULTS: In all models, the presence of caregiver-reported dementia at the initial interview was significantly associated with the change in the number of retained roots (p < .05). The adjusted coefficient of determination (R2 ) of model 5, which included all the predetermined independent factors, was .168. CONCLUSIONS: Caregiver-reported dementia may be a risk factor for an increase in the number of retained roots among patients who receive home-visit dental treatment and may serve as an indicator of the need for regular and proactive oral hygiene management.

  7. Correlation between Changes in the Transverse Relaxation Time and Electromyographic Measurements of the Superficial Masseter and Temporal Muscles Peer-reviewed

    Tsuyoshi Fujii, Satoshi Yamaguchi, Yul Wan Sung, Makoto Watanabe, Yoshinori Hattori

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　19　(3)　268-275　2020/08/03

    DOI： 10.2463/mrms.tn.2019-0035 　

    eISSN： 1880-2206

  8. とろみ調整食品が口腔テクスチャー感覚に及ぼす影響

    伊藤 佳彦, 古川 奈緒, 伊藤 和花菜, 田中 恭恵, 山口 哲史, 服部 佳功

    日本顎口腔機能学会雑誌　25　(1)　36-37　2018/09

    Publisher: 日本顎口腔機能学会

    ISSN： 1340-9085

    eISSN： 1883-986X

  9. Analysis of masticatory muscle coordination during unilateral single-tooth clenching using muscle functional magnetic resonance imaging International-journal Peer-reviewed

    S. Yamaguchi, C. Okada, Y. Watanabe, M. Watanabe, Y. Hattori

    Journal of Oral Rehabilitation　45　(1)　9-16　2017/11/15

    DOI： 10.1111/joor.12583 　

    ISSN： 0305-182X

    eISSN： 1365-2842

  10. mfMRIによる咀嚼筋局所活動分布における多様性の可視化と共通傾向の解析

    山口哲史, 岡田知佳, 渡部芳彦, 渡辺誠, 服部佳功

    東北大学歯学雑誌　35　(2)　20-26　2017

  11. 舌－硬口蓋間のテクスチャー感覚と舌乳頭の形態的特徴との関係：予備的研究 Peer-reviewed

    伊藤佳彦, 遠藤耕生, 田中恭恵, 山口哲史, 服部佳功

    日本顎口腔機能学会雑誌　23　(2)　85-95　2017

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.23.85 　

    ISSN： 1340-9085

    eISSN： 1883-986X

  12. Contribution of each masticatory muscle to the bite force determined by MRI using a novel metal-free bite force gauge and an index of total muscle activity Peer-reviewed

    Minoru Takahashi, Satoshi Yamaguchi, Tsuyoshi Fujii, Makoto Watanabe, Yoshinori Hattori

    JOURNAL OF MAGNETIC RESONANCE IMAGING　44　(4)　804-813　2016/10

    DOI： 10.1002/jmri.25223 　

    ISSN： 1053-1807

    eISSN： 1522-2586

  13. Evaluation of masticatory activity during unilateral single tooth clenching using muscle functional magnetic resonance imaging Peer-reviewed

    C. Okada, S. Yamaguchi, Y. Watanabe, M. Watanabe, Y. Hattori

    JOURNAL OF ORAL REHABILITATION　43　(8)　583-590　2016/08

    DOI： 10.1111/joor.12404 　

    ISSN： 0305-182X

    eISSN： 1365-2842

  14. Calcification during bone healing in a standardised rat calvarial defect assessed by micro-CT and SEM-EDX Peer-reviewed

    H. Okata, M. Nakamura, A. Henmi, S. Yamaguchi, Y. Mikami, H. Shimauchi, Y. Sasano

    ORAL DISEASES　21　(1)　74-82　2015/01

    DOI： 10.1111/odi.12212 　

    ISSN： 1354-523X

    eISSN： 1601-0825

  15. 機能画像を利用した新しい顎口腔機能検査の可能性～mfMRIによる咀嚼筋活動の3次元解析～ Invited

    山口哲史

    日本補綴歯科学会誌　6　(1)　38-40　2014/01

    Publisher: Japan Prosthodontic Society

    DOI： 10.2186/ajps.6.38 　

    ISSN： 1883-4426

  16. 高齢者の歯科治療における最適時間帯を探る -アンケート調査からの考察- Peer-reviewed

    玉澤佳純, 玉澤かほる, 岩松正明, 山口哲史

    老年歯科医学　27　(2)　69-76　2012

    DOI： 10.11259/jsg.27.69 　

  17. The Influence of Mastication on the Dopaminergic System in the Rat Brain

    Hiroki Takahashi, Toshihito Funaki, Akito Tsuboi, Makoto Watanabe, Satoshi Yamaguchi

    Interface oral Health Science 2011　2012

  18. Quantitative analysis of masticatory activity during unilateral mastication using muscle fMRI Peer-reviewed

    S. Yamaguchi, S. Itoh, Y. Watanabe, A. Tsuboi, M. Watanabe

    ORAL DISEASES　17　(4)　407-413　2011/05

    DOI： 10.1111/j.1601-0825.2010.01767.x 　

    ISSN： 1354-523X

    eISSN： 1601-0825

  19. 口腔環境の変化による全身的影響の検討 -オクルーザルスプリント装着による脳活動の変化と心理的順応-

    渡辺誠, 山口哲史, 伊藤進太郎, 小牧健一朗, 佐藤智昭, 高津匡樹, 坪井明人, 服部佳功, 渡部芳彦, 阿部一彦, 山本光璋

    感性福祉研究所年報　7　73-85　2006/08

  20. Overall activity of all masticatory muscles during lateral excursion Peer-reviewed

    S Yamaguchi, H Rikimaru, K Yamaguchi, M Itoh, M Watanabe

    JOURNAL OF DENTAL RESEARCH　85　(1)　69-73　2006/01

    DOI： 10.1177/154405910608500112 　

    ISSN： 0022-0345

  21. Measurement of masticatory activity by application of PET-MRI registration technique

    S. Yamaguchi, H. Rikimaru, K. Yamaguchi, M. Itoh, M. Watanabe

    International Congress Series　1284　61-62　2005/09

    DOI： 10.1016/j.ics.2005.06.103 　

    ISSN： 0531-5131

  22. Oral health status in an elderly urban population : the Tsurugaya project

    Takashi Ohi, Masahiko Kikuchi, Yoshinori Tamazawa, Yoshinori Hattori, Akito Tsuboi, Masaki Takatsu, Chiaki Sato, Masaaki Iwamatsu, Shintaro Ito, Kenichiro Komaki, Satoshi Yamaguchi, Atsushi Hozawa, Ichiro Tsuji, Makoto Watanabe, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry:The Tohoku University 21st Century COE Program Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation (CRESCENDO), Special Care Unit for Infection Control Tohoku University Dental Hospital, Comprehensive Dentistry Tohoku University Dental Hospital, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry, Division of Epidemiology Department of Public Health and Forensic Medicine Tohoku University Graduate School of Medicine, Division of Epidemiology Department of Public Health and Forensic Medicine Tohoku University Graduate School of Medicine, Division of Aging and Geriatric Dentistry Department of Oral Function and Morphology Tohoku University Graduate School of Dentistry:The Tohoku University 21st Century COE Program Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation (CRESCENDO)

    24　(1)　16-23　2005/06

    Publisher:

    ISSN： 0287-3915

Show all ︎Show first 5

Misc. 28

  1. マウス実験的歯周炎モデルを用いた加齢と炎症が及ぼす歯槽骨吸収への影響

    中村 恵, Yang Mu-Chen, 山口 哲史, 大方 広志, 笹野 泰之

    日本歯周病学会会誌　65　(秋季特別)　129-129　2023/10

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

    eISSN： 1880-408X

  2. 部分床義歯を用いて骨隆起と咬合高径低下による咀嚼障害を回復した症例

    山口 哲史

    日本補綴歯科学会誌　15　(3)　417-420　2023/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  3. 現在歯数と歯周炎の交互作用が海馬形態と認知機能に与える影響 大迫研究における縦断MRI解析

    山口 哲史, 村上 任尚, 小宮山 貴将, 大井 孝, 三好 慶忠, 山田 唱, 関 大蔵, 大久保 孝義, 服部 佳功

    日本老年歯科医学会総会・学術大会プログラム・抄録集　34回　[GP4-3]　2023/06

    Publisher: (一社)日本老年歯科医学会

  4. 要介護高齢者における補綴診療の目標設定を考える 臨床倫理の観点から考える要介護高齢者に対する補綴診療

    山口 哲史

    日本補綴歯科学会誌　14　(東北・北海道支部学術大会特別号)　21-21　2022/10

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  5. 部分床義歯を用いて顕著な骨隆起と咬合高径低下による咀嚼障害を回復した症例

    山口 哲史

    日本補綴歯科学会誌　14　(特別号)　373-373　2022/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  6. 現在歯数と歯周炎の交互作用が脳形態変化に与える影響 大迫研究における縦断MRI解析

    山口 哲史, 小宮山 貴将, 大井 孝, 村上 任尚, 佐藤 倫広, 沼崎 貴子, 三好 慶忠, 遠藤 耕生, 山田 唱, 目時 弘仁, 大久保 孝義, 服部 佳功

    日本補綴歯科学会誌　14　(特別号)　256-256　2022/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  7. 東北大学病院口腔内科・リエゾンセンターにおける初診患者の動向

    庄司 憲明, 千葉 雅俊, 永井 宏和, 佐藤 しづ子, 菅原 由美子, 小川 徹, 重光 竜二, 岩間 亮介, 鈴木 飛佳理, 工藤 葉子, 安田 真, 水田 健太郎, 田中 恭恵, 山口 哲史, 八幡 祥生, 五十嵐 薫

    東北大学歯学雑誌　39/40/41　(2/1-2/1)　52-53　2022/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  8. 網羅的遺伝子解析を用いた高齢マウスの下顎における細胞外マトリックス分解酵素の発現

    影山 曜子, 中村 恵, 猪狩 洋平, 山口 哲史, 服部 佳功, 笹野 泰之, 小口 綾貴子, 村川 泰裕

    Journal of Oral Biosciences Supplement　2019　230-230　2019/10

    Publisher: (一社)歯科基礎医学会

    ISSN： 2187-2333

    eISSN： 2187-9109

  9. 訪問歯科症例において初診時の認知症がその後の歯科口腔保健に及ぼす影響の解析

    堀込 ゆかり, 山口 哲史, 駒形 守俊, 駒井 伸也, 小牧 健一朗, 宮田 英樹, 菅野 和彦, 伊藤 勢津子, 板橋 志保, 佐藤 はるみ, 岡橋 美奈子, 岸 さやか, 服部 佳功

    老年歯科医学　32　(2)　130-130　2017/09

    Publisher: (一社)日本老年歯科医学会

    ISSN： 0914-3866

  10. 訪問歯科症例において初診時の認知症がその後の歯科口腔保健に及ぼす影響の解析

    堀込 ゆかり, 山口 哲史, 駒形 守俊, 駒井 伸也, 小牧 健一朗, 宮田 英樹, 菅野 和彦, 伊藤 勢津子, 板橋 志保, 佐藤 はるみ, 岡橋 美奈子, 岸 さやか, 服部 佳功

    日本老年歯科医学会総会・学術大会プログラム・抄録集　28回　126-126　2017/06

    Publisher: (一社)日本老年歯科医学会

  11. 舌乳頭の形態計測的特徴と口腔のテクスチャー感覚の関連

    伊藤佳彦, 遠藤耕生, 田中恭恵, 山口哲史, 服部佳功

    日本顎口腔機能学会雑誌　23　(2)　118‐119-119　2017/03/31

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.23.118 　

    ISSN： 1340-9085

    eISSN： 1883-986X

  12. mfMRIによる咀嚼筋活動解析の基礎的検証~筋電図との相関~

    藤居剛志, 山口哲史, 渡辺誠, 服部佳功

    日本顎口腔機能学会雑誌　23　(2)　144‐145-145　2017/03/31

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.23.144 　

    ISSN： 1340-9085

  13. 舌乳頭の形態計測的特徴と口腔のテクスチャー感覚の関連

    伊藤佳彦, 遠藤耕生, 田中恭恵, 山口哲史, 服部佳功

    日本顎口腔機能学会学術大会プログラム・事前抄録集　57th　14‐15　2016

  14. mfMRIによる咀嚼筋活動解析の基礎的検証~筋電図との相関~

    藤居剛志, 山口哲史, 渡辺誠, 服部佳功

    日本顎口腔機能学会学術大会プログラム・事前抄録集　57th　40‐41　2016

  15. 咬合支持状態の異なるクレンチングにおける全咀嚼筋の活動様相~新たな咬合力計を応用したmfMRIによる解析~

    高橋実, 山口哲史, 渡辺誠, 服部佳功

    日本顎口腔機能学会雑誌　21　(2)　150-151　2015/03/31

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.21.150 　

    ISSN： 1340-9085

  16. 【補綴臨床イノベーションのための若手研究者の挑戦 2 治療、検査法の新たな展開】機能画像を利用した新しい顎口腔機能検査の可能性 mfMRIによる咀嚼筋活動の3次元解析

    山口 哲史

    歯界展望　123　(5)　1006-1011　2014/05

    Publisher: 医歯薬出版(株)

    ISSN： 0011-8702

  17. 咬合支持状態の異なるクレンチングにおける全咀嚼筋の活動様相~新たな咬合力計を応用したmfMRIによる解析~

    高橋実, 山口哲史, 渡辺誠, 服部佳功

    日本顎口腔機能学会学術大会プログラム・事前抄録集　53rd　42-43　2014

  18. 臨床イノベーションのための若手研究者の挑戦 治療、検査法の新たな展開 機能画像を利用した新しい顎口腔機能検査の可能性 mfMRIによる咀嚼筋活動の3次元解析

    山口 哲史

    日本補綴歯科学会誌　5　(特別号)　98-98　2013/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  19. muscle functional MRIによる咀嚼筋活動の3次元可視化

    山口 哲史, 岡田 知佳, 渡部 芳彦, 渡辺 誠

    日本顎口腔機能学会雑誌　18　(2)　180-181　2012/02

    Publisher: 日本顎口腔機能学会

    ISSN： 1340-9085

    eISSN： 1883-986X

  20. muscle functional MRIを用いた片側クレンチングにおける咀嚼筋活動の定量的解析

    岡田 知佳, 山口 哲史, 渡部 芳彦, 渡辺 誠

    日本顎口腔機能学会雑誌　16　(2)　134-135　2010/02

    Publisher: 日本顎口腔機能学会

    ISSN： 1340-9085

    eISSN： 1883-986X

  21. 居宅高齢者における口腔状態と大脳白質病変の関連

    水尻 大希, 伊藤 進太郎, 木之村 重男, 大井 孝, 山口 哲史, 辻 一郎, 福田 寛, 渡邉 誠

    老年歯科医学　23　(2)　181-181　2008/09

    Publisher: (一社)日本老年歯科医学会

    ISSN： 0914-3866

    eISSN： 1884-7323

  22. 咬合支持・咬合力と転倒骨折発生との関連

    大井孝, 服部佳功, 坪井明人, 佐藤智昭, 伊藤進太郎, 小牧健一朗, 土谷昌広, 山口哲史, 水戸祐子, 菊池雅彦, 辻一郎, 渡邉誠

    日本補綴歯科学会学術大会プログラム・抄録集　117th　109　2008/06

    ISSN： 1883-4426

  23. 地域高齢者における口腔状態と精神機能の縦断的検討

    西村一将, 高津匡樹, 大井孝, 菊池雅彦, 玉澤佳純, 服部佳功, 坪井明人, 佐藤智昭, 岩松正明, 伊藤進太郎, 小牧健一朗, 土谷昌広, 山口哲史, 大森芳, 辻一郎, 渡辺誠

    老年歯科医学　22　(2)　146-147　2007/09/30

    Publisher: (一社)日本老年歯科医学会

    ISSN： 0914-3866

  24. 中高齢者における抑うつスコアの高値に関わる歯科的要因:大迫研究

    大井孝, 伊藤進太郎, 山口哲史, 菊池雅彦, 服部佳功, 福田寛, 星晴久, 今井潤, 渡邉誠

    老年歯科医学　22　(2)　178-179　2007/09/30

    Publisher: (一社)日本老年歯科医学会

    ISSN： 0914-3866

  25. 骨格筋機能的磁気共鳴画像を用いた咀嚼筋活動の測定

    山口 哲史, 伊藤 進太郎, 渡部 芳彦, 今泉 修, 渡辺 誠

    日本補綴歯科学会雑誌　51　(116回特別)　217-217　2007/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  26. 高齢者の歯科治療における最適時間帯を探る

    玉澤 佳純, 岩松 正明, 玉澤 かほる, 山口 哲史, 渡辺 誠

    老年歯科医学　21　(3)　275-276　2006/12

    Publisher: (一社)日本老年歯科医学会

    ISSN： 0914-3866

    eISSN： 1884-7323

  27. 健常高齢者における歯数と脳灰白質容積の関連 A morphometric study

    伊藤 進太郎, 山口 哲史, 高津 匡樹, 菊池 雅彦, 渡辺 誠, 木之村 重男, 後藤 了以, 井上 健太郎, 瀧 靖之, 佐藤 和則, 福田 寛, 辻 一郎

    日本医学放射線学会雑誌　64　(8)　578-578　2004/11

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  28. FDG-PETによる下顎側方運動時の咀嚼筋活動の測定

    山口 哲史, 力丸 尚, 渡辺 誠, 山口 慶一郎, 伊藤 正敏

    核医学　41　(2)　174-174　2004/05

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

Show all ︎Show first 5

Books and Other Publications 2

  1. パーシャルデンチャー治療失敗回避のためのポイント47

    山口哲史, 高橋正敏, 服部佳功

    クインテッセンス出版　2017

  2. バウチャー 無歯顎患者の補綴治療 原著第12版

    田中久敏, 小谷野潔, 市川哲雄, 渡辺誠, 山口哲史

    医歯薬出版株式会社　2008/04/25

Presentations 25

  1. 高齢肺炎患者への急性期における歯科介入と転帰との関連

    大井 孝, 菊地 真友, 服部 佳功, 山口 哲史, 田中 恭恵, 猪狩 洋平, 小宮山 貴将, 伊藤 佳彦, 伊藤 有希, 小林 誠一, 矢内 勝

    一般社団法人日本老年歯科医学会 第36回学術大会　2025/06/27

  2. 高齢マウスにおける頭頂骨規格化骨欠損修復に関する形態学的検討

    猪狩 洋平, 中村 恵, 山口 哲史, 服部 佳功

    一般社団法人日本老年歯科医学会第36回学術大会　2025/06/29

  3. エビデンスに基づく舌機能訓練タスクの選択:mfMRIによる舌筋活動分布解析の応用

    佐藤 全弘, 山口 哲史, 服部 佳功

    公益社団法人日本補綴歯科学会第134回学術大会　2025/05/18

  4. 多角的な視点から見る口腔と全身の関連 Invited

    山口哲史

    第34回日本全身咬合学会学術大会　2024/11/23

  5. A New Perspective on the Number of Teeth in Older Adults Invited

    Satoshi Yamaguchi

    CAMPUS Asia Plus in Dentistry International Symposium 2024　2024/10/20

  6. 家族介護者の介護負担感と口腔保健指標との関連

    岸 さやか, 山口 哲史, 小宮山 貴将, 猪狩 洋平, 田中 恭恵, 伊藤 佳彦, 伊藤 有希, 内ケ崎 一徹, 黒田 雅博, 齋藤 貫, 佐藤 全弘, 関 大蔵, 大道寺 明也, 岡橋 美奈子, 阿部 吏芳, 小牧 健一朗, 成田 憲司, 小菅 玲, 服部 佳功

    日本老年歯科医学会第35回学術大会　2024/06/30

  7. 舌抵抗訓練における舌圧方向が筋活動分布と舌圧向上効果に及ぼす影響：骨格筋機能的磁気共鳴画像による検討

    佐藤 全弘, 山口 哲史, 服部 佳功

    日本老年歯科医学会第35回学術大会　2024/06/29

  8. 急性期高齢者肺炎患者の転帰と歯科介入に関する後ろ向き調査

    大井 孝, 菊地 真友, 服部 佳功, 山口 哲史, 田中 恭恵, 猪狩 洋平, 小宮山 貴将, 伊藤 佳彦, 小林 誠一, 矢内 勝

    日本老年歯科医学会第35回学術大会　2024/06/29

  9. 現在歯数と歯周炎の交互作用が海馬形態と認知機能に与える影響 ー大迫研究における縦断MRI解析ー

    山口 哲史, 村上 任尚, 小宮山 貴将, 大井 孝, 三好 慶忠, 山田 唱, 関 大蔵, 大久保 孝義, 服部 佳功

    第33回日本老年学会総会（一般社団法人日本老年歯科医学会第34回学術大会）　2023/06/16

  10. 臨床倫理の観点から考える要介護高齢者に対する補綴診療 Invited

    山口 哲史

    令和４年度 公益社団法人 日本補綴歯科学会 東北・北海道支部学術大会　2022/10/16

  11. 現在歯数と歯周炎の交互作用が脳形態変化に与える影響：大迫研究における縦断MRI解析

    山口哲史, 小宮山貴将, 大井 孝, 村上任尚, 佐藤倫広, 沼崎貴子, 三好慶忠, 遠藤耕生, 山田 唱, 目時弘仁, 大久保孝義, 服部佳功

    公益社団法人日本補綴歯科学会第131回学術大会　2022/07/17

  12. マウス下顎のトランスクリプトーム解析による老化関連細胞外マトリックス分解酵素 の同定

    影山曜子, 中村恵, 猪狩洋平, 山口哲史, 服部佳功, 笹野泰之

    第125回日本解剖学会総会・全国学術集会　2020/03/26

  13. 網羅的遺伝子解析を用いた高齢マウスの下顎における細胞外マトリック ス分解酵素の発現

    影山曜子, 中村恵, 猪狩洋平, 山口哲史, 服部佳功, 笹野泰之

    第61回歯科基礎医学会学術大会　2019/10/12

  14. とろみ調整食品が口腔テクスチャー感覚に及ぼす影響

    伊藤佳彦, 古川奈緒, 伊藤和花菜, 田中恭恵, 山口哲史, 服部佳功

    日本顎口腔機能学会第60回学術大会　2018/04

  15. 骨格筋機能的磁気共鳴画像による咀嚼筋活動評価の特性

    藤居剛志, 山口哲史, 渡邉誠, 服部佳功

    日本補綴歯科学会平成29年度東北・北海道支部学術大会　2017/10

  16. 舌乳頭の形態計測的特徴と口腔テクスチャー感覚の関連

    伊藤佳彦, 遠藤耕生, 田中恭恵, 山口哲史, 服部佳功

    日本顎口腔機能学会第57回学術大会　2016/10

  17. mfMRIによる咀嚼筋活動解析の基礎的検証～筋電図との相関～

    藤居剛志, 山口哲史, 渡邉誠, 服部佳功

    日本顎口腔機能学会第57回学術大会　2016/10

  18. 咬合支持状態の異なるクレンチングにおける全咀嚼筋の活動様相 -新たな咬合力計を応用したmfMRIによる解析-

    日本顎口腔機能学会第53回学術大会　2014/10/05

  19. 機能画像を利用した 新しい顎口腔機能検査の可能性 ～mfMRIによる咀嚼筋活動の3次元解析～ Invited

    山口哲史

    日本補綴歯科学会第122回学術大会 イブニングセッション2　2013/05

  20. muscle functional MRIによる咀嚼筋活動の3次元可視化

    山口哲史, 岡田知佳, 渡部芳彦, 渡辺誠

    日本顎口腔機能学会第47回学術大会　2011/10/22

  21. muscle functional MRI を用いた片側クレンチングにおける咀嚼筋活動の定量的解析

    岡田知佳, 山口哲史, 渡部芳彦, 渡辺誠

    日本顎口腔機能学会 第34回学術大会　2009/11/28

  22. 骨格筋機能的磁気共鳴画像を用いた咀嚼筋活動の測定

    山口哲史, 伊藤進太郎, 渡部芳彦, 今泉 修, 渡辺 誠

    第116回(社)日本補綴歯科学会学術大会　2007/05/18

  23. Measurement of masticatory activity by application of PET-MRI registration technique

    S.Yamaguchi, H.Rikimaru, K.Yamaguchi, M.Itoh, M.Watanabe

    インターフェイス口腔健康科学国際シンポジウム　2005/02/02

  24. 地域の医療と介護を支えるための補綴歯科治療 Invited

    山口 哲史

    令和6年度宮城県歯科医師会 日本補綴歯科学会共催生涯学習セミナー　2024/10/19

  25. 3次元機能画像を応用した咀嚼筋活動分布解析による咬合評価の可能性 Invited

    山口哲史

    第28回日本全身咬合学会学術大会　2018/11/24

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Industrial Property Rights 1

  1. ３次元画像処理装置、３次元画像処理方法及びプログラム

    山口 哲史, 中村 恵

    Property Type: Patent

Research Projects 14

  1. 海馬形態の縦断解析による口腔状態が認知症リスクに及ぼす影響とメカニズムの解明

    山口 哲史, 大久保 孝義, 佐藤 倫広, 戸恒 智子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2024/04 - 2028/03

  2. 咀嚼筋fMRIを応用した口腔機能とフレイルの多角的関連解析

    山口 哲史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

    More details Close

    新型コロナウィルス感染症の流行に伴い、感染リスクの高い口腔内への咬合力測定装置の挿入が困難となり、解析対象となるmfMRIの撮像をほとんど行うことが出来なかった。そのため、過去に別の研究課題で撮像した頭頚部MRIを利用して、3次元画像の空間的標準化を応用した咀嚼筋の体積および脂肪化率の自動計測パイプライン構築の検討を行った。 まず、医用画像Registrationの分野で精度に定評のある「Advanced Normalization Tools（ANTs）」の脳MRIテンプレート作成スクリプトである「antsMultivariateTemplateConstruction2.sh」を利用して、30名の頭頚部MRIから頭頚部全体のテンプレート画像を生成した。テンプレート作成に必要なパラメータは、試行錯誤的に最適な数値を検索した。完成したテンプレート画像上で各咀嚼筋の外形をトレースすることで、各咀嚼筋の領域に対応するマスク画像を作成した。 次に、ANTsを利用して、各被験者の頭頚部MRIのテンプレート画像に対する空間的標準化を実施した。その際に出力される変換パラメータ画像を利用して、咀嚼筋マスク画像の逆変換を行い、各被験者の咀嚼筋領域を反映するマスク画像を出力した。マスク画像のマスク領域の体積を算出し、これを各咀嚼筋の体積とした。また、逆変換したマスク画像を利用して各被験者の咀嚼筋内における信号強度の分布を求めることで、脂肪化率の指標とした。これらの処理はスクリプトによる自動化が可能であり、バイアスを排除した自動解析を実施できることが確認された。

  3. 大規模縦断コホートデータを用いた義歯の認知症予防効果のエビデンスの探索

    坪井 明人, 瀧 靖之, 大井 孝, 山口 哲史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04 - 2024/03

  4. Three-dimensional analysis of muscle function distribution inside the tongue using muscle fMRI

    Yamaguchi Satoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

    More details Close

    The purpose of this study was to visualize the distribution of muscle activity inside the tongue during tongue pressure training in three dimensions by applying anatomical standardization and statistical parametric mapping to analysis of muscle functional magnetic resonance imaging (mfMRI). First, the local activity distribution in the masticatory muscles, which have a more distinct morphology than the tongue, was analyzed to establish the image processing method needed for this study, and then the muscle activity distribution inside the tongue in one subject was analyzed. The results of this study show that the distribution of muscle activity inside the tongue can be visualized.

  5. Experimental investigation of bone repair using a mouse model lacking osteoclast differentiation: are osteoclasts necessary for bone repair?

    Nakamura Megumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    The incidence of c-fos deficient (-/-) mice was examined by genotyping with PCR using DNA extracted from embryos obtained from mating between c-fos heterozygous (+/-) mice. The results showed that heterozygous (+/-) mice accounted for more than half of the total number of mice (61.2%), while the incidence of c-fos deficient (-/-) mice was low at 14.3%. Micro-CT analysis was performed at 4, 8, and 12 weeks after creation of a standardized defect in the parietal bone of wild-type mice to examine the process of bone defect repair. The results showed that the amount of repaired bone increased over time, and that repaired bone was not only formed from the margins of the defect, but also sporadically formed within the defect. Furthermore, our histological analysis with hematoxylin and eosin staining showed consistent findings with the results of micro-CT analysis.

  6. Three-dimensional analysis of masticatory muscle local activity with spatial normalization and statistical imaging

    Yamaguchi Satoshi, WATANABE makoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2019/03/31

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    This study was started with the aim of three-dimensional visualizing masticatory muscle internal activity by applying spatial normalization and statistical imageing when analyzing the masticatory muscle activity with mfMRI. First, the characteristics of T2 shift associated with exercise within the masticatory muscles were clarified by comparison with electromyographic measurements. Second, a technique for spatial normalization of the masticatory muscles was established and its accuracy was verified. The results of this study suggested the possibility of visualizing the masticatory muscle local activity common to the subject group, and the basis of the method was established.

  7. Establishment of the MR imaging method to visualize the functional load of stomatognathic system associated with loss of occlusal support.

    Yamaguchi Satoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

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    This study was planned to visualize and quantitatively analyze the functional load of masticatory muscles and temporomandibular joint. However, the masticatory activities were analyzed under the various scclusal support conditions with the total muscle T2 shift as a new index using a novel bite force gauge, due to the problem in the MR imaging of temporomandibular joint. The novel bite force gauge provided reliable real-time measurements of the bite force in the strong magnetic field of an MRI scanner. The index of total muscle activity was found to be a stronger correlation than the traditional index to the real bite force in the inter-subject study.

  8. Roles played by histamine in strenuous or prolonged masseter muscle activity.

    WATANABE Makoto, ENDO Yasuo, YAMAGUCHI Satoshi, TSUCHIYA Masahiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2011/04/01 - 2015/03/31

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    Bruxism and/or clenching, resulting in fatigue or dysfunction of masseter muscles (MM), may cause temporomandibular disorders (TMD). Functional support of the microcirculation is critical for prolonged muscle activity. Histamine is a regulator of the microcirculation and is supplied by release from its stores and/or by de novo production via the induction of histidine decarboxylase (HDC). In the present study, we examined the roles of histamine and HDC in MM activity. Experiments were conducted using our R+G+ model. In addition that fexofenadine (a histamine H1 receptor antagonist) reduced MM activity, both H1 receptor-deficient and HDC-deficient mice exhibited low MM activity. Prolonged R+G+ induced HDC activity in MM. These results suggest that: (i) peripheral histamine supports strenuous MM activity; (ii) strenuous MM activity stimulates mast cells to release histamine and to induce HDC; and (iii) peripheral histamine H1 receptor antagonists may be effective in treating TMD.

  9. The study of the brain plasticity adapting to the changes of intraoral environment based on the brain molecules

    WATANABE Makoto, TSUBOI Akito, YAMAGUCHI Satoshi, KIKUCHI Masahiko, ITO Shintaro, FUKUDA Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2008 - 2010

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    The aim of the present study was to investigate the effects of different mastication on the dopaminergic system in the rat striatum using positron emission tomography (PET)and brain microdialysis (MD). Male F344 rats were fed solid diets (group-S)or powder diets (group-P). These rats were bred reach to 8 and 60 weeks old under the above conditions. As the result of PET study, the accumulation of 11C-RAC at 60 weeks old of group-S was lower than that of group-P. As the result of MD study, dopamine release at 8 and 60 weeks old of group-P was higher than that of group-S. These results suggest that the different mastication influenced on dopaminergic system at the molecular level.

  10. The study of age-related changes of stomatognathic function using the analysis of masticatory activities by muscle fMRI

    YAMAGUCHI Satoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2008 - 2010

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    The new features about the masticatory activities during unilateral clenching were suggested in the present study, which differed from the previous electromyographic studies. Especially, the present results suggested that the superior head of the lateral pterygoid muscle was controlled independently from other masticatory muscles, and the activity of superior head of ipsilateral lateral pterygoid muscle increased in association with the changes in the occlusal point from the first molar to the first premolar during unilateral clenching.

  11. A study of functional change of swallowing with ageing

    TSUBOI Akito, TSUBOI Akito

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2007 - 2008

  12. Study of adaptability to oral environmental changes from brain plasticity perspective

    WATANABE Makoto, TSUBOI Akito, ITOH Shintaro, YAMAGUCHI Satoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2006 - 2007

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    Nine subjects (mean age 28.7) underwent fMRI during chewing gum on the left side of jaw, with and without a resin cap on the lingual region of the maxillary left canine. fMRI acquisition protocol used in the present study has been optimised in our pilot study. fMRI was performed before, immediately after and 30min after applying resin cap. Six out of nine subjects were asked to masticate a wax cube on the left side of jaw in each condition to determine masticatory efficiency. fMRI data were analyzed with SPM2 (Statistical Parametric Mapping 2) to determine differences of brain activity (p=0.001 uncorrected, extent threshold=20voxels). During left side gum chewing, bilateral cerebellar posterior lobe and the proximal part of right supramarginal gyrus were more activated immediately after applying resin cap than before applying it. The activation of cerebellum might show the activity of cerebellum during "motor learning". During left side gum chewing, right cerebellar posterior lobe were less activated 30min after applying resin cap than immediately after applying it. This result might show that the motor learning of left masticatory muscles and the adaptation to left gum chewing with regin cap were achievement. The brain regions showing negative correlation to masticatory efficiency were bilateral postcentral gyrus, left precentral gyrus, right cingulate gyrus, right superior temporal gyrus, right cerebellar posterior lobe and right cerebellar anterior lobe. These findings suggest that right cerebellar posterior and anterior lobe were activated to achieve motor learning of left masticatory muscles to remedy reduced masticatory efficiency immediately after applying resin cap, and were less activated with the improvement of masticatory efficiency and achievement of motor learning 30min after applying resin cap.

  13. 骨格筋fMRIの応用による口腔顔面痛の原因究明

    山口 哲史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 東北大学

    2006 - 2007

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    骨格筋機能的磁気共鳴画像による咀嚼筋活動の定量的測定法を確立し、緊張型頭痛患者に応用することを目的として、健常な若年成人被験者に1Hzの下顎側方運動を一定時間(2.5分、5分、7.5分、10分)行わせてMR画像を撮像し、下顎側方運動を行う時間の増加に伴う各咀嚼筋のT2値の変化を確認した。各課題運動の間には40分間の安静を確保した。各被験者のMR画像の全スライス上で、両側咬筋、内側翼突筋、外側翼突筋の外形をトレースすることにより関心体積を設定し、各関心体積における平均T2値を算出した。その結果、左側方運動を「安静→2.5分→5分→7.5分→10分」の順番で行わせた場合(実験1)には、下顎運動時間の増加に伴うT2値の増加が観察され、特に右側(平衡側)の外側翼突筋で著明な増加が確認された。一方、右側方運動を「10分→7.5分→5分→2.5分→安静」の順番で行わせた場合(実験2)には、下顎運動時間の増加に伴うT2値の増加は左側方運動の場合と比較して明確でなく、筋間の差もあまり観察されなかった。実験1の結果ではT2値と運動量は相関しており、10分咀嚼後の各筋のT2値の増加量を運動量と考えると筋電図による過去の報告と一致していた。しかし、ガム咀嚼時と比較すると各筋のT2値の変化量は小さく、さらに実験2の結果では各筋におけるT2値の増加量は運動量と相関せず、各筋間の差も不明確であった。ガム咀嚼と比較して下顎側方運動は負荷が小さいためにT2値の変化が安定せず、ノイズや測定順序の影響を受けやすいと考えられる。下顎運動時の咀嚼筋活動測定にT2値の変化を利用するためには、負荷を適切に増大させる工夫が必要であると考えられる。今後も緊張型頭痛を含めた臨床的研究への応用に向けた更なる検証を行う予定である。

  14. Study of brain plasticity and functional and psychological adaptability caused by alteration of oral environment

    WATANABE Makoto, HATTORI Yoshinori, ITOH Shintaro, KOMAKI Kenichiro, TSUBOI Akito, YAMAGUCHI Satoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: TOHOKU UNIVERSITY

    2003 - 2005

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    We evaluated brain function using functional magnetic resonance image (fMRI) to demonstrate brain activity change of mastication. fMRI acquisition protocol used in the present study has been optimised in our pilot study. 6 adult male subjects (mean age 23.2) were told to use occlusal splint for 7 days. fMRI was performed on day 1, 3, 7 of occlusal splint use and day 7 after occlusal splint removal. After fMRI acquisition, subjective sensations of every subject were recorded with "Visual Analog Scale". fMRI data were analyzed with SPM2 (Statistical Parametric Mapping 2) to determine differences of brain activity between with and without occlusal Splint (p=0.001 uncorrected, extent threshold=20voxels). On day 1 of occlusal splint use, cerebellum and left middle frontal gyrus (BA10) were more activated with occlusal splint than without it. These results showed the activation of cerebellum and frontal lobe during "motor learning". On day 3 and 7 of occlusal splint use, no difference of activity was detected in cerebellum and frontal lobe. On day 7 after occlusal splint removal, left premotor cortex was more activated with occlusal splint than without it. These findings suggest that brain neural network corresponding to new pattern of masticatory movement was constructed and maintained after occlusal splint removal. Although we analyzed association between subjective sensation score by VAS and brain activity using SPM2, no significant correlation was observed.

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Teaching Experience 3

  1. 口腔機能回復学Ⅱ（老年歯学）

  2. 口腔機能回復学Ⅱ（全部床義歯学・実習）

  3. 口腔機能回復学Ⅱ（全部床義歯学・講義）

Social Activities 4

  1. 元気に過ごすためのお口の健康

    千葉クリニック市民医学講座, 於仙台北山市民センター

    2019/07/24 -

  2. 生涯おいしく食べるために ～要介護になってからの口腔ケア～

    目指せ！生涯楽しむ健口生活, 市民公開講座, 於宮城・仙台口腔保健センター.

    2018/06/09 -

  3. 心身の健康を支える口の働き ～しっかり噛んで楽しく食べよう～

    歯と口の健康づくり市民のつどい, 市民公開講座, 目指せ！生涯楽しむ健口生活, 於宮城・仙台口腔保健センター

    2017/06/10 -

  4. [日本国内] 「国際シンポジウム 画像科学技術の製薬に対する寄与」市民公開講座

    2007/09/17 -

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    歯科診療におけるPET/SPECTの寄与

Media Coverage 27

  1. Evidence Grows for the Association Between Oral Health and Neurologic Disorders

    NeurologyToday

    2025/07/17

    Type: Internet

  2. 生老病死の秘密 [超高齢社会特集 逆老化生存公式 - 第3部 咀嚼力、脳老化予防の先兵]

    韓国放送公社(KBS)　生老病死の秘密

    2025/06/25

    Type: TV or radio program

  3. Research Suggests Good Oral Health May Reduce Risk of Cognitive Decline

    American Academy of Neurology　Brain & Life

    2023/12

    Type: Promotional material

  4. 重度の歯周病の歯を残すことで海馬の萎縮が速まる可能性あり。

    Dentalism 2023 SEPTEMBER No.59

    2023/09/25

    Type: Promotional material

  5. GOOD DENTAL CARE TIED TO BETTER BRAIN HEALTH

    The Fisher Center for Alzheimer's Research Foundation

    2023/09/20

    Type: Internet

  6. Missing Teeth and Inflamed Gums May Be Tied to Brain Health

    American Academy of Neurology　NeurologyToday

    2023/08/15

    Type: Internet

  7. 海馬の萎縮速度との関連性を解明 重度の歯周病⇒痛みなくても抜歯を

    公益財団法人認知症予防財団　新時代

    2023/08

    Type: Promotional material

  8. Poor dental health may increase Alzheimer's risk

    Medical News Today

    2023/07/07

    Type: Internet

  9. Scientists Reveal Link Between Brushing Teeth and Dementia

    Newsweek (International)

    2023/07/07

    Type: Internet

  10. TAKING GOOD CARE OF YOUR TEETH MAY BE GOOD FOR YOUR BRAIN

    American Academy of Neurology　Press Release

    2023/07/05

    Type: Other

  11. Periodontitis May Accelerate Hippocampal Atrophy in Older Adults

    Neurology ADVISOR

    2023/08/28

    Type: Internet

  12. 重度の歯周病の歯を無理に残しても「海馬の萎縮を早める」可能性

    ナゾロジー

    2023/08/15

    Type: Internet

  13. 歯を健康に保つことが「海馬」の縮小を遅らせる!? 日本の研究でわかったオーラルヘルスと脳の関係

    FYTTE

    2023/08/11

    Type: Internet

  14. 歯周病と海馬萎縮との関連性解明 重度なら痛みなくても抜歯を

    公益財団法人認知症予防財団　トピックス

    2023/08

    Type: Internet

  15. I'm a neurologist - these are the six things I do every day to keep my mind sharp

    Daily Mail

    2023/07/22

    Type: Internet

  16. La santé de vos dents serait liée à celle de votre cerveau

    Sciences et Avenir (France)

    2023/07/20

    Type: Internet

  17. Evidence mounts that gum disease shrinks and inflames your brain

    The New Daily

    2023/07/15

    Type: Internet

  18. Une mauvaise hygiène dentaire favoriserait le déclin cognitif

    Futura Sciences (France)

    2023/07/10

    Type: Internet

  19. https://www.mirror.co.uk/news/health/silent-killer-disease-could-caused-30416846

    The Mirror

    2023/07/09

    Type: Internet

  20. Disturbing New Finding Links Cognitive Decline to Dental Hygiene

    Science Alert

    2023/07/08

    Type: Internet

  21. Gum Disease and Tooth Loss Linked to Shrinking Hippocampus

    LabRoots

    2023/07/07

    Type: Internet

  22. Denti curati, cervello in salute

    Scienza e Farmaci (Italia)

    2023/07/07

    Type: Internet

  23. Poor Oral Health May Increase Risk for Memory Issues

    Newsmax

    2023/07/07

    Type: Internet

  24. Esto es lo que le pasa al cerebro cuando no te lavas los dientes

    La Razón (Spain)

    2023/07/07

    Type: Internet

  25. This Is What Happens To Your Brain When You Don’t Brush Your Teeth

    Then24

    2023/07/07

    Type: Internet

  26. Brushing, Flossing Could Help Shield Your Brain From Dementia

    U.S. News & World Report

    2023/07/06

    Type: Internet

  27. Number of Teeth, Periodontitis in Older Adults Linked to Hippocampal Atrophy

    2023/07/06

    Type: Internet

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