DMAPO/Boc2O‐Mediated One‐Pot Direct N1‐Acylation of Indazole with Carboxylic Acids: A Practical Synthesis of N1‐Functionalized Alkyl Indazoles

Atsushi Umehara, Soma Shimizu, Makoto Sasaki

European Journal of Organic Chemistry　e202400123　2024/02/14

DOI： 10.1002/ejoc.202400123 　

ISSN： 1434-193X

eISSN： 1099-0690

Synthesis of Bulky N‐Acyl Heterocycles by DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Less Nucleophilic N‐Heterocycles with α‐Fully Substituted Carboxylic Acids Peer-reviewed

Atsushi Umehara, Soma Shimizu, Makoto Sasaki

Advanced Synthesis & Catalysis　365　2367-2376　2023/06/16

DOI： 10.1002/adsc.202300487 　

ISSN： 1615-4150

eISSN： 1615-4169

DMAPO/Boc2O-Mediated One-Pot Direct N-Acylation of Less Nucleophilic N-Heterocycles with Carboxylic Acids Peer-reviewed

Atsushi Umehara, Soma Shimizu, Makoto Sasaki

CHemCatChem　15　e202201596　2023/01

DOI： 10.1002/cctc.202201596 　

ISSN： 1867-3880

eISSN： 1867-3899

Convergent and scalable synthesis of ABCDE-ring fragment of Caribbean ciguatoxin C-CTX-1 Peer-reviewed

Makoto Sasaki, Miku Seida, Atsushi Umehara

The Journal of Organic Chemistry　88　(1)　403-413　2023/01

DOI： 10.1021/acs.joc.2c02414 　

ISSN： 0022-3263

eISSN： 1520-6904

Convergent synthesis of the HIJKLMN-Ring Fragment of Caribbean Ciguatoxin C-CTX-1 by a Late-Stage Reductive Olefin Coupling Peer-reviewed

Makoto Sasaki, Kotaro Iwasaki, Keisuke Arai, Naoya Hamada, Atsushi Umehara

Bulletin of the Chemical Society of Japan　95　(5)　819-824　2022/05

DOI： 10.1246/bcsj.20220070 　

ISSN： 0009-2673

eISSN： 1348-0634

Gambierol Blocks a K+ Current Fraction without Affecting Catecholamine Release in Rat Fetal Adrenomedullary Cultured Chromaffin Cells Peer-reviewed

Evelyne Benoit, Sébastien Schlumberger, Jordi Molgó, Makoto Sasaki, Haruhiko Fuwa, Rol, Bournaud

Toxins　14　254　2022/04

DOI： 10.3390/toxins14040254 　

Determination of toxicity equivalency factors for ciguatoxins using human sodium channels Peer-reviewed

Sandra Raposo-Garcia, M. Carmen Louzao, Haruhiko Fuwa, Makoto Sasaki, Luis M. Botana

Food and Chemical Toxicology　160　112812　2022/01

DOI： 10.1016/j.fct.2022.112812 　

Synthesis and structural implication of the JKLMN-ring of Caribbean ciguatoxin C-CTX-1 Peer-reviewed

M. Sasaki, K. Iwasaki, K. Arai

The Journal of Organic Chemistry　86　4580-4597　2021/03

Unified total synthesis of (–)-enigmazole A and (–)-15-O-methylenigmazole A Peer-reviewed

K. Sakurai, K. Sakamoto, M. Sasaki, H. Fuwa

Chemistry Asian Journal　15　3494-3502　2020/10

Gambierol potently increases evoked quantal transmitter release and reverses pre-and post-synaptic blockade at vertebrate neuromuscular junctions Peer-reviewed

Jordi Molgó, Sébastien Schlumberger, Makoto Sasaki, Haruhiko Fuwa, M. Carmen Louzao, Luis M. Botana, Denis Servent, Evelyne Benoit

439　(2020)　106-116　2019/07

Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging International-journal Peer-reviewed

S. Yanagi, T. Sugai, T. Noguchi, M. Kawakami, M. Sasaki, S. Niwa, A. Sugimoto, H. Fuwa

Organic & biomolecular chemistry　20　(28)　6771-6776　2019/07

DOI： 10.1039/c9ob01276a 　

Studies towards total synthesis of Caribbean ciguatoxin C-CTX-1: Synthesis of the LMN-ring fragment through reductive olefin cross-coupling Peer-reviewed

M. Sasaki, K. Iwasaki, K. Arai

Organic Letters　20　7163-7166　2018/10

DOI： 10.1021/acs.orglett.8b03102 　

Total Synthesis of (−)-Enigmazole A Peer-reviewed

Keisuke Sakurai, Makoto Sasaki, Haruhiko Fuwa

Angewandte Chemie - International Edition　57　(18)　5143-5146　2018/04/23

DOI： 10.1002/anie.201801561 　

ISSN： 1521-3773 1433-7851

Total Synthesis of Polycavernosides A and B, Two Lethal Toxins from Red Alga Peer-reviewed

Kotaro Iwasaki, Satori Sasaki, Yusuke Kasai, Yuki Kawashima, Shohei Sasaki, Takanori Ito, Mari Yotsu-Yamashita, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　82　(24)　13204-13219　2017/12

DOI： 10.1021/acs.joc.7b02293 　

ISSN： 0022-3263

Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid beta Expression in Mice Brains: Implications in AD Pathology Peer-reviewed

Eva Alonso, Andres C. Vieira, Ines Rodriguez, Rebeca Alvarino, Sandra Gegunde, Haruhiko Fuwa, Yuto Suga, Makoto Sasaki, Amparo Alfonso, Jose Manuel Cifuentes, Luis M. Botana

ACS CHEMICAL NEUROSCIENCE　8　(6)　1358-1367　2017/06

DOI： 10.1021/acschemneuro.7b00012 　

ISSN： 1948-7193

Exploiting Ruthenium Carbene-Catalyzed Reactions in Total Synthesis of Marine Oxacyclic Natural Products Invited Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　89　(12)　1403-1415　2016/12

DOI： 10.1246/bcsj.20160224 　

ISSN： 0009-2673

eISSN： 1348-0634

Stereodivergent Synthesis and Configurational Assignment of the C1-C15 Segment of Amphirionin-5 Peer-reviewed

Moemi Kanto, Sota Sato, Masashi Tsuda, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　81　(19)　9105-9121　2016/10

DOI： 10.1021/acs.joc.6b01700 　

ISSN： 0022-3263

Diastereoselective Ring-Closing Metathesis as a Means to Construct Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable Gambierol Derivative Peer-reviewed

Yu Onodera, Kazuaki Hirota, Yuto Suga, Keiichi Konoki, Mari Yotsu-Yamashita, Makoto Sasaki, Haruhiko Fuwa

JOURNAL OF ORGANIC CHEMISTRY　81　(18)　8234-8252　2016/09

DOI： 10.1021/acs.joc.6b01302 　

ISSN： 0022-3263

Toward a total synthesis of amphidinolide N: convergent synthesis of the C1-C13 segment Peer-reviewed

Atsushi Toyoshima, Makoto Sasaki

TETRAHEDRON LETTERS　57　(31)　3532-3534　2016/08

DOI： 10.1016/j.tetlet.2016.06.107 　

ISSN： 0040-4039

Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid Peer-reviewed

Sachie Furumochi, Tatsuya Onoda, Yuko Cho, Haruhiko Fuwa, Makoto Sasaki, Mari Yotsu-Yamashita, Keiichi Konoki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　26　(13)　2992-2996　2016/07

DOI： 10.1016/j.bmcl.2016.05.027 　

ISSN： 0960-894X

eISSN： 1464-3405

Cytotoxicity of goniodomin A and B in non contractile cells Peer-reviewed

Begona Espina, Eva Cagide, M. Carmen Louzao, Natalia Vilarino, Mercedes R. Vieytes, Yoshiyuki Takeda, Makoto Sasaki, Luis M. Botana

TOXICOLOGY LETTERS　250　10-20　2016/05

DOI： 10.1016/j.toxlet.2016.04.001 　

ISSN： 0378-4274

eISSN： 1879-3169

Complete Stereochemical Assignment of Campechic Acids A and B Peer-reviewed

Ruri Isaka, Linkai Yu, Makoto Sasaki, Yasuhiro Igarashi, Haruhiko Fuwa

JOURNAL OF ORGANIC CHEMISTRY　81　(9)　3638-3647　2016/05

DOI： 10.1021/acs.joc.6b00290 　

ISSN： 0022-3263

Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8-C29 Fragment Peer-reviewed

Yuki Kawashima, Atsushi Toyoshima, Haruhiko Fuwa, Makoto Sasaki

ORGANIC LETTERS　18　(9)　2232-2235　2016/05

DOI： 10.1021/acs.orglett.6b00871 　

ISSN： 1523-7060

eISSN： 1523-7052

Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (-)-LyngbyalosideB Peer-reviewed

Haruhiko Fuwa, Naoya Yamagata, Yuta Okuaki, Yuya Ogata, Asami Saito, Makoto Sasaki

CHEMISTRY-A EUROPEAN JOURNAL　22　(20)　6815-6829　2016/05

DOI： 10.1002/chem.201600341 　

ISSN： 0947-6539

eISSN： 1521-3765

Progress toward the Total Synthesis of Goniodomin A: Stereocontrolled, Convergent Synthesis of the C12-C36 Fragment Peer-reviewed

Haruhiko Fuwa, Seiji Matsukida, Taro Miyoshi, Yuki Kawashima, Tomoyuki Saito, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　81　(6)　2213-2227　2016/03

DOI： 10.1021/acs.joc.5b02650 　

ISSN： 0022-3263

Synthetic Studies on Amphirionin-5: Stereochemical Assignment/Reassignment of the C1-C9 Portion through Stereodivergent Synthesis Peer-reviewed

Moemi Kanto, Makoto Sasaki

ORGANIC LETTERS　18　(1)　112-115　2016/01

DOI： 10.1021/acs.orglett.5b03346 　

ISSN： 1523-7060

eISSN： 1523-7052

Concise synthesis of the C15-C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A Peer-reviewed

Haruhiko Fuwa, Keita Sakamoto, Takashi Muto, Makoto Sasaki

TETRAHEDRON　71　(37)　6369-6383　2015/09

DOI： 10.1016/j.tet.2015.04.001 　

ISSN： 0040-4020

Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation Peer-reviewed

J. A. Rubiolo, C. Vale, V. Martin, H. Fuwa, M. Sasaki, L. M. Botana

ARCHIVES OF TOXICOLOGY　89　(7)　1119-1134　2015/07

DOI： 10.1007/s00204-014-1299-2 　

ISSN： 0340-5761

eISSN： 1432-0738

Evaluation of gambierol and its analogs for their inhibition of human K(v)1.2 and cytotoxicity Peer-reviewed

Keiichi Konoki, Yuto Suga, Haruhiko Fuwa, Mari Yotsu-Yamashita, Makoto Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　25　(3)　514-518　2015/02

DOI： 10.1016/j.bmcl.2014.12.022 　

ISSN： 0960-894X

eISSN： 1464-3405

STUDIES TOWARD THE TOTAL SYNTHESIS OF AMPHIDINOLIDE N: STEREOCONTROLLED SYNTHESIS OF THE C13-C29 SEGMENT Peer-reviewed

Makoto Sasaki, Yuki Kawashima, Haruhiko Fuwa

HETEROCYCLES　90　(1)　579-599　2015/01

DOI： 10.3987/COM-14-S(K)66 　

ISSN： 0385-5414

eISSN： 1881-0942

Total Synthesis, Stereochemical Reassignment, and Biological Evaluation of (-)-Lyngbyaloside B Peer-reviewed

Haruhiko Fuwa, Yuta Okuaki, Naoya Yamagata, Makoto Sasaki

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　54　(3)　868-873　2015/01

DOI： 10.1002/anie.201409629 　

ISSN： 1433-7851

eISSN： 1521-3773

Concise synthesis of the A/BCD-ring fragment of gambieric acid A Peer-reviewed

Haruhiko Fuwa, Ryo Fukazawa, Makoto Sasaki

FRONTIERS IN CHEMISTRY　2　116　2015/01

DOI： 10.3389/fchem.2014.00116 　

eISSN： 2296-2646

Concise Synthesis of the C15-C38 Fragment of Okadaic Acid: Application of the Suzuki-Miyaura Reaction to Spiroacetal Synthesis Peer-reviewed

Haruhiko Fuwa, Keita Sakamoto, Takashi Muto, Makoto Sasaki

ORGANIC LETTERS　17　(2)　366-369　2015/01

DOI： 10.1021/ol503491t 　

ISSN： 1523-7060

eISSN： 1523-7052

Programmed Cell Death Induced by (-)-8,9-Dehydroneopeltolide in Human Promyelocytic Leukemia HL-60 Cells under Energy Stress Conditions Peer-reviewed

Haruhiko Fuwa, Mizuho Sato, Makoto Sasaki

MARINE DRUGS　12　(11)　5576-5589　2014/11

DOI： 10.3390/md12115576 　

ISSN： 1660-3397

Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain Peer-reviewed

Haruhiko Fuwa, Takuma Noguchi, Masato Kawakami, Makoto Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　24　(11)　2415-2419　2014/06

DOI： 10.1016/j.bmcl.2014.04.031 　

ISSN： 0960-894X

eISSN： 1464-3405

Total Synthesis and Structure Revision of Didemnaketal B Peer-reviewed

Haruhiko Fuwa, Takashi Muto, Kumiko Sekine, Makoto Sasaki

CHEMISTRY-A EUROPEAN JOURNAL　20　(7)　1848-1860　2014/02

DOI： 10.1002/chem.201303713 　

ISSN： 0947-6539

eISSN： 1521-3765

Stereoselective Synthesis of Medium-Sized Cyclic Ethers: Application of C-Glycosylation Chemistry to Seven- to Nine-Membered Lactone-Derived Thioacetals and Their Sulfone Counterparts Peer-reviewed

Yuto Suga, Haruhiko Fuwa, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　79　(4)　1656-1682　2014/02

DOI： 10.1021/jo4025545 　

ISSN： 0022-3263

Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras Peer-reviewed

Haruhiko Fuwa, Kenkichi Noto, Masato Kawakami, Makoto Sasaki

CHEMISTRY LETTERS　42　(9)　1020-1022　2013/09

DOI： 10.1246/cl.130322 　

ISSN： 0366-7022

eISSN： 1348-0715

Total Synthesis of the Proposed Structure of Didemnaketal B Peer-reviewed

Haruhiko Fuwa, Kumiko Sekine, Makoto Sasaki

ORGANIC LETTERS　15　(15)　3970-3973　2013/08

DOI： 10.1021/ol4017518 　

ISSN： 1523-7060

eISSN： 1523-7052

Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: Identification of pharmacophoric elements Peer-reviewed

Haruhiko Fuwa, Masato Kawakami, Kenkichi Noto, Takashi Muto, Yuto Suga, Keiichi Konoki, Mari Yotsu-Yamashita, Makoto Sasaki

Chemistry - A European Journal　19　(25)　8100-8110　2013/06/17

DOI： 10.1002/chem.201300664 　

ISSN： 0947-6539 1521-3765

Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues Peer-reviewed

Kazuya Ishigai, Haruhiko Fuwa, Keisuke Hashizume, Ryo Fukazawa, Yuko Cho, Mari Yotsu-Yamashita, Makoto Sasaki

Chemistry - A European Journal　19　(17)　5276-5288　2013/04/22

DOI： 10.1002/chem.201204303 　

ISSN： 0947-6539 1521-3765

Total Synthesis of 13-Demethyllyngbyaloside B Peer-reviewed

Haruhiko Fuwa, Naoya Yamagata, Asami Saito, Makoto Sasaki

ORGANIC LETTERS　15　(7)　1630-1633　2013/04

DOI： 10.1021/ol400408w 　

ISSN： 1523-7060

Total synthesis and biological evaluation of (-)-exiguolide analogues: importance of the macrocyclic backbone Peer-reviewed

Haruhiko Fuwa, Kana Mizunuma, Makoto Sasaki, Takaya Suzuki, Hiroshi Kubo

ORGANIC & BIOMOLECULAR CHEMISTRY　11　(21)　3442-3450　2013

DOI： 10.1039/c3ob40131f 　

ISSN： 1477-0520

A CONCISE SYNTHESIS OF THE AB-RING FRAGMENT OF (-)-GAMBIEROL Peer-reviewed

Haruhiko Fuwa, Kazuaki Hirota, Makoto Sasaki

HETEROCYCLES　86　(1)　127-132　2012/12

DOI： 10.3987/COM-12-S(N)21 　

ISSN： 0385-5414

Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives Peer-reviewed

Haruhiko Fuwa, Takuma Noguchi, Kenkichi Noto, Makoto Sasaki

ORGANIC & BIOMOLECULAR CHEMISTRY　10　(40)　8108-8112　2012/10

DOI： 10.1039/c2ob26189h 　

ISSN： 1477-0520

eISSN： 1477-0539

P-60 Synthesis and Biological Evaluation of Structurally Simplified Analogues of Gambierol(Poster Presentation)

Suga Yuto, Fuwa Haruhiko, Goto Tomomi, Konno Yu, Sasaki Makoto, Alonso Eva, Vale Carmen, Botana Luis Miguel

Symposium on the Chemistry of Natural Products, symposium papers　(54)　633-638　2012/09/01

DOI： 10.24496/tennenyuki.54.0_633 　

32 Total Synthesis and Complete Stereostructure of Gambieric Acid A(Oral Presentation)

Fuwa Haruhiko, Ishigai Kazuya, Hashizume Keisuke, Sasaki Makoto

Symposium on the Chemistry of Natural Products, symposium papers　(54)　187-192　2012/09/01

DOI： 10.24496/tennenyuki.54.0_187 　

Stereoselective Synthesis of the C1-C16 Fragment of Goniodomin A Peer-reviewed

Motohiro Nakajima, Haruhiko Fuwa, Makoto Sasaki

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　85　(9)　948-956　2012/09

DOI： 10.1246/bcsj.20120152 　

ISSN： 0009-2673

eISSN： 1348-0634

Effect of Gambierol and Its Tetracyclic and Heptacyclic Analogues in Cultured Cerebellar Neurons: A Structure-Activity Relationships Study Peer-reviewed

Sheila Perez, Carmen Vale, Eva Alonso, Haruhiko Fuwa, Makoto Sasaki, Yu Konno, Tomomi Goto, Yuto Suga, Mercedes R. Vieytes, Luis M. Botana

CHEMICAL RESEARCH IN TOXICOLOGY　25　(9)　1929-1937　2012/09

DOI： 10.1021/tx300242m 　

ISSN： 0893-228X

Total Synthesis and Complete Stereostructure of Gambieric Acid A Peer-reviewed

Haruhiko Fuwa, Kazuya Ishigai, Keisuke Hashizume, Makoto Sasaki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　134　(29)　11984-11987　2012/07

DOI： 10.1021/ja305864z 　

ISSN： 0002-7863

Total Synthesis of (-)-Polycavernoside A: Suzuki-Miyaura Coupling Approach Peer-reviewed

Yusuke Kasai, Takanori Ito, Makoto Sasaki

ORGANIC LETTERS　14　(12)　3186-3189　2012/06

DOI： 10.1021/ol301278e 　

ISSN： 1523-7060

Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-beta and Tau Pathology with Voltage-Gated Potassium Channel and N-Methyl-D-aspartate Receptor Implications Peer-reviewed

Eva Alonso, Haruhiko Fuwa, Carmen Vale, Yuto Suga, Tomomi Goto, Yu Konno, Makoto Sasaki, Frank M. LaFerla, Mercedes R. Vieytes, Lydia Gimenez-Llort, Luis M. Botana

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　134　(17)　7467-7479　2012/05

DOI： 10.1021/ja300565t 　

ISSN： 0002-7863

Stereoselective Synthesis of 2,6-Cis-Substituted Tetrahydropyrans: Bronsted Acid-Catalyzed Intramolecular Oxa-Conjugate Cyclization of alpha,beta-Unsaturated Ester Surrogates Peer-reviewed

Haruhiko Fuwa, Naoki Ichinokawa, Kenkichi Noto, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　77　(6)　2588-2607　2012/03

DOI： 10.1021/jo202179s 　

ISSN： 0022-3263

Total Synthesis of (-)-Brevenal: A Streamlined Strategy for Practical Synthesis of Polycyclic Ethers Peer-reviewed

Makoto Ebine, Haruhiko Fuwa, Makoto Sasaki

CHEMISTRY-A EUROPEAN JOURNAL　17　(49)　13754-13761　2011/12

DOI： 10.1002/chem.201101437 　

ISSN： 0947-6539

eISSN： 1521-3765

Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors Peer-reviewed

Masaki Unno, Masanobu Shinohara, Koichiro Takayama, Hideharu Tanaka, Kenta Teruya, Katsumi Doh-ura, Ryuichi Sakai, Makoto Sasaki, Masao Ikeda-Saito

JOURNAL OF MOLECULAR BIOLOGY　413　(3)　667-683　2011/10

DOI： 10.1016/j.jmb.2011.08.043 　

ISSN： 0022-2836

Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: convergent synthesis of a fully elaborated GHIJ-ring fragment Peer-reviewed

Koichi Tsubone, Keisuke Hashizume, Haruhiko Fuwa, Makoto Sasaki

TETRAHEDRON　67　(35)　6600-6615　2011/09

DOI： 10.1016/j.tet.2011.05.082 　

ISSN： 0040-4020

Synthetic Studies on Dragmacidin D: Synthesis and Assembly of Three Fragments Towards an Advanced Intermediate Peer-reviewed

Masato Oikawa, Minoru Ikoma, Makoto Sasaki

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　(24)　4654-4666　2011/08

DOI： 10.1002/ejoc.201100242 　

ISSN： 1434-193X

A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones via palladium-catalyzed coupling of thioesters Peer-reviewed

Haruhiko Fuwa, Kana Mizunuma, Seiji Matsukida, Makoto Sasaki

TETRAHEDRON　67　(27-28)　4995-5010　2011/07

DOI： 10.1016/j.tet.2011.03.114 　

ISSN： 0040-4020

Comparative Cytotoxicity of Gambierol versus Other Marine Neurotoxins Peer-reviewed

E. Cagide, M. C. Louzao, B. Espina, I. R. Ares, M. R. Vieytes, M. Sasaki, H. Fuwa, C. Tsukano, Y. Konno, M. Yotsu-Yamashita, L. A. Paquette, T. Yasumoto, L. M. Botana

CHEMICAL RESEARCH IN TOXICOLOGY　24　(6)　835-842　2011/06

DOI： 10.1021/tx200038j 　

ISSN： 0893-228X

Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor Peer-reviewed

Chang-Shen Qiu, Leanne Lash-Van Wyhe, Makoto Sasaki, Ryuichi Sakai, Geoffrey T. Swanson, Robert W. Gereau

PAIN　152　(5)　1052-1060　2011/05

DOI： 10.1016/j.pain.2011.01.018 　

ISSN： 0304-3959

Biosynthesis-Inspired Intramolecular Oxa-Conjugate Cyclization of alpha,beta-Unsaturated Thioesters: Stereoselective Synthesis of 2,6-cis-Substituted Tetrahydropyrans Peer-reviewed

Haruhiko Fuwa, Kenkichi Noto, Makoto Sasaki

ORGANIC LETTERS　13　(7)　1820-1823　2011/04

DOI： 10.1021/ol200333p 　

ISSN： 1523-7060

A Convergent Synthesis of the C1-C16 Segment of Goniodomin A via Palladium-Catalyzed Organostannane-Thioester Coupling Peer-reviewed

Haruhiko Fuwa, Motohiro Nakajima, Jinglu Shi, Yoshiyuki Takeda, Tomoyuki Saito, Makoto Sasaki

ORGANIC LETTERS　13　(5)　1106-1109　2011/03

DOI： 10.1021/ol1031409 　

ISSN： 1523-7060

Total synthesis and biological assessment of (-)-Exiguolide and analogues Peer-reviewed

Haruhiko Fuwa, Takaya Suzuki, Hiroshi Kubo, Takao Yamori, Makoto Sasaki

Chemistry - A European Journal　17　(9)　2678-2688　2011/02/25

DOI： 10.1002/chem.201003135 　

ISSN： 0947-6539 1521-3765

Synthetic studies on goniodomin A: convergent assembly of the C15-C36 segment via palladium-catalyzed organostannane-thioester coupling Peer-reviewed

Tomoyuki Saito, Haruhiko Fuwa, Makoto Sasaki

TETRAHEDRON　67　(2)　429-445　2011/01

DOI： 10.1016/j.tet.2010.11.017 　

ISSN： 0040-4020

Studies toward the total synthesis of gambieric acids: convergent synthesis of the GHIJ-ring fragment having a side chain Peer-reviewed

Koichi Tsubone, Keisuke Hashizume, Haruhiko Fuwa, Makoto Sasaki

TETRAHEDRON LETTERS　52　(4)　548-551　2011/01

DOI： 10.1016/j.tetlet.2010.11.127 　

ISSN： 0040-4039

Asymmetric Synthesis and in vivo Biological Inactivity of the Right-Hand Terpenoid Fragment of Terpendole E Peer-reviewed

Masato Oikawa, Ryo Hashimoto, Makoto Sasaki

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　(3)　538-546　2011/01

DOI： 10.1002/ejoc.201001104 　

ISSN： 1434-193X

Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling Peer-reviewed

Masahiro Sonoshita, Masahiro Aoki, Haruhiko Fuwa, Koji Aoki, Hisahiro Hosogi, Yoshiharu Sakai, Hiroki Hashida, Arimichi Takabayashi, Makoto Sasaki, Sylvie Robine, Kazuyuki Itoh, Kiyoko Yoshioka, Fumihiko Kakizaki, Takanori Kitamura, Masanobu Oshima, Makoto Mark Taketo

CANCER CELL　19　(1)　125-137　2011/01

DOI： 10.1016/j.ccr.2010.11.008 　

ISSN： 1535-6108

A CONCISE TOTAL SYTHESIS OF (+/-)-CENTROLOBINE Peer-reviewed

Haruhiko Fuwa, Kenkichi Noto, Makoto Sasaki

HETEROCYCLES　82　(1)　641-647　2010/12

DOI： 10.3987/COM-10-S(E)37 　

ISSN： 0385-5414

Convergent Assembly of the Spiroacetal Subunit of Didemnaketal B Peer-reviewed

Haruhiko Fuwa, Sayaka Noji, Makoto Sasaki

ORGANIC LETTERS　12　(22)　5354-5357　2010/11

DOI： 10.1021/ol1024713 　

ISSN： 1523-7060

The marine polyether gambierol enhances muscle contraction and blocks a transient K+ current in skeletal muscle cells Peer-reviewed

Sebastien Schlumberger, Gilles Ouanounou, Emmanuelle Girard, Makoto Sasaki, Haruhiko Fuwa, M. Carmen Louzao, Luis M. Botana, Evelyne Benoit, Jordi Molgo

TOXICON　56　(5)　785-791　2010/10

DOI： 10.1016/j.toxicon.2010.06.001 　

ISSN： 0041-0101

Total Synthesis of (-)-Exiguolide

Fuwa Haruhiko, Sasaki Makoto

Symposium on the Chemistry of Natural Products, symposium papers　(52)　181-186　2010/09/01

DOI： 10.24496/tennenyuki.52.0_181 　

An enantioselective total synthesis of aspergillides A and B Peer-reviewed

Haruhiko Fuwa, Hiroshi Yamaguchi, Makoto Sasaki

TETRAHEDRON　66　(38)　7492-7503　2010/09

DOI： 10.1016/j.tet.2010.07.062 　

ISSN： 0040-4020

Studies toward the Total Synthesis of Gambieric Acids: Stereocontrolled Synthesis of a DEFG-Ring Model Compound Peer-reviewed

Haruhiko Fuwa, Sayaka Noji, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　75　(15)　5072-5082　2010/08

DOI： 10.1021/jo1008146 　

ISSN： 0022-3263

A series of structurally novel heterotricyclic alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor-selective antagonists Invited Peer-reviewed

M. B. Gill, S. Frausto, M. Ikoma, M. Sasaki, M. Oikawa, R. Sakai, G. T. Swanson

BRITISH JOURNAL OF PHARMACOLOGY　160　(6)　1417-1429　2010/07

DOI： 10.1111/j.1476-5381.2010.00784.x 　

ISSN： 0007-1188

eISSN： 1476-5381

Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs Peer-reviewed

Masato Oikawa, Minoru Ikoma, Makoto Sasaki, Martin B. Gill, Geoffrey T. Swanson, Keiko Shimamoto, Ryuichi Sakai

BIOORGANIC & MEDICINAL CHEMISTRY　18　(11)　3795-3804　2010/06

DOI： 10.1016/j.bmc.2010.04.044 　

ISSN： 0968-0896

eISSN： 1464-3391

ChemInform Abstract: Studies Toward the Total Synthesis of Gymnocin A, a Cytotoxic Polyether: A Highly Convergent Entry to the F-N Ring Fragment. Peer-reviewed

Makoto Sasaki, Chihiro Tsukano, Kazuo Tachibana

ChemInform　33　(38)　no　2010/05

DOI： 10.1002/chin.200238231 　

Calcium Oscillations Induced by Gambierol in Cerebellar Granule Cells

E. Alonso, C. Vale, M. Sasaki, H. Fuwa, Y. Konno, S. Perez, M. R. Vieytes, L. M. Botana

JOURNAL OF CELLULAR BIOCHEMISTRY　110　(2)　497-508　2010/05

DOI： 10.1002/jcb.22566 　

ISSN： 0730-2312

An Efficient Synthesis of 2,6-Disubstituted 2,3-Dihydro-4H-pyran-4-ones via Sonogashira Coupling of p-Toluenethiol Esters Peer-reviewed

Haruhiko Fuwa, Seiji Matsukida, Makoto Sasaki

SYNLETT　1239　(8)　1239-1242　2010/05

DOI： 10.1055/s-0029-1219794 　

ISSN： 0936-5214

Stereoselective Synthesis of Substituted Tetrahydropyrans via Domino Olefin Cross-Metathesis/Intramolecular Oxa-Conjugate Cyclization Peer-reviewed

Haruhiko Fuwa, Kenkichi Noto, Makoto Sasaki

ORGANIC LETTERS　12　(7)　1636-1639　2010/04

DOI： 10.1021/ol100431m 　

ISSN： 1523-7060

A Unified Total Synthesis of Aspergillides A and B Peer-reviewed

Haruhiko Fuwa, Hiroshi Yamaguchi, Makoto Sasaki

ORGANIC LETTERS　12　(8)　1848-1851　2010/04

DOI： 10.1021/ol100463a 　

ISSN： 1523-7060

Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine Peer-reviewed

L. Leanne Lash-Van Wyhe, Pekka A. Postila, Koichi Tsubone, Makoto Sasaki, Olli T. Pentikainen, Ryuichi Sakai, Geoffrey T. Swanson

NEUROPHARMACOLOGY　58　(3)　640-649　2010/03

DOI： 10.1016/j.neuropharm.2009.11.013 　

ISSN： 0028-3908

eISSN： 1873-7064

Total Synthesis of (-)-Exiguolide Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

ORGANIC LETTERS　12　(3)　584-587　2010/02

DOI： 10.1021/ol902778y 　

ISSN： 1523-7060

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan Peer-reviewed

Makoto Ebine, Yuto Suga, Haruhiko Fuwa, Makoto Sasaki

ORGANIC & BIOMOLECULAR CHEMISTRY　8　(1)　39-42　2010

DOI： 10.1039/b919673k 　

ISSN： 1477-0520

eISSN： 1477-0539

A Concise Total Synthesis of (+)-Neopeltolide Peer-reviewed

Haruhiko Fuwa, Asami Saito, Makoto Sasaki

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　49　(17)　3041-3044　2010

DOI： 10.1002/anie.201000624 　

ISSN： 1433-7851

Regioselective Domino Metathesis of Unsymmetrical 7-Oxanorbornenes with Electron-Rich Vinyl Acetate toward Biologically Active Glutamate Analogues Peer-reviewed

Masato Oikawa, Minoru Ikoma, Makoto Sasaki, Martin B. Gill, Geoffrey T. Swanson, Keiko Shimamoto, Ryuichi Sakai

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　5531　(32)　5531-5548　2009/11

DOI： 10.1002/ejoc.200900580 　

ISSN： 1434-193X

Toward the Total Synthesis of Goniodomin A, An Actin-Targeting Marine Polyether Macrolide: Convergent Synthesis of the C15-C36 Segment Peer-reviewed

Tomoyuki Saito, Haruhiko Fuwa, Makoto Sasaki

ORGANIC LETTERS　11　(22)　5274-5277　2009/11

DOI： 10.1021/ol902217q 　

ISSN： 1523-7060

Studies toward the Total Synthesis of Gambieric Acid A

Fuwa Haruhiko, Ishigai Kazuya, Noji Sayaka, Tsubone Koichi, Hashizume Keisuke, Sasaki Makoto

Symposium on the Chemistry of Natural Products, symposium papers　(51)　359-364　2009/09/01

DOI： 10.24496/tennenyuki.51.0_359 　

Stereocontrolled Synthesis of the DEFG-ring Skeleton of Gambieric Acids Peer-reviewed

Haruhiko Fuwa, Sayaka Noji, Makoto Sasaki

CHEMISTRY LETTERS　38　(8)　866-867　2009/08

DOI： 10.1246/cl.2009.866 　

ISSN： 0366-7022

eISSN： 1348-0715

Synthetic Studies on Gambieric Acids, Potent Antifungal Polycyclic Ether Natural Products: Reassignment of the Absolute Configuration of the Nonacyclic Polyether Core by NMR Analysis of Model Compounds Peer-reviewed

Haruhiko Fuwa, Kazuya Ishigai, Tomomi Goto, Akihiro Suzuki, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　74　(11)　4024-4040　2009/06

DOI： 10.1021/jo900332q 　

ISSN： 0022-3263

Proteomic Analysis Reveals Multiple Patterns of Response in Cells Exposed to a Toxin Mixture Peer-reviewed

Gian Luca Sala, Giuseppe Ronzitti, Makoto Sasaki, Haruhiko Fuwa, Takeshi Yasumoto, Albertino Bigiani, Gian Paolo Rossini

CHEMICAL RESEARCH IN TOXICOLOGY　22　(6)　1077-1085　2009/06

DOI： 10.1021/tx900044p 　

ISSN： 0893-228X

eISSN： 1520-5010

Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine Peer-reviewed

Karla Frydenvang, L. Leanne Lash, Peter Naur, Pekka A. Postila, Darryl S. Pickering, Caleb M. Smith, Michael Gajhede, Makoto Sasaki, Ryuichi Sakai, Olli T. Pentikainen, Geoffrey T. Swanson, Jette S. Kastrup

JOURNAL OF BIOLOGICAL CHEMISTRY　284　(21)　14219-14229　2009/05

DOI： 10.1074/jbc.M808547200 　

ISSN： 0021-9258

SYNTHESIS OF OPEN-CHAIN C21-C40 FRAGMENT OF AZASPIRACID-1 Peer-reviewed

Masato Oikawa, Taizo Iwayama, Makoto Sasaki

HETEROCYCLES　78　(3)　609-615　2009/03

DOI： 10.3987/COM-08-11555 　

ISSN： 0385-5414

Synthesis of 2-Substituted Indoles and Indolines via Suzuki-Miyaura Coupling/5-endo-trig Cyclization Strategies Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　74　(1)　212-221　2009/01

DOI： 10.1021/jo801985a 　

ISSN： 0022-3263

Chemospecific Allylation and Domino Metathesis of 7-Oxanorbornenes for Skeletal and Appendage Diversity Peer-reviewed

Minoru Ikoma, Masato Oikawa, Makoto Sasaki

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　2009　(1)　72-84　2009/01

DOI： 10.1002/ejoc.200800781 　

ISSN： 1434-193X

Total Synthesis and Biological Evaluation of (+)-Neopeltolide and Its Analogues Peer-reviewed

Haruhiko Fuwa, Asami Saito, Shinya Naito, Keiichi Konoki, Mari Yotsu-Yamashita, Makoto Sasaki

CHEMISTRY-A EUROPEAN JOURNAL　15　(46)　12807-12818　2009

DOI： 10.1002/chem.200901675 　

ISSN： 0947-6539

Synthetic studies on dragmacidin D: synthesis of the left-hand fragment Peer-reviewed

Minoru Ikoma, Masato Oikawa, Makoto Sasaki

TETRAHEDRON LETTERS　49　(50)　7197-7199　2008/12

DOI： 10.1016/j.tetlet.2008.10.020 　

ISSN： 0040-4039

Regioselective Domino Metathesis of 7-Oxanorbornenes and Its Application to the Synthesis of Biologically Active Glutamate Analogues Peer-reviewed

Minoru Ikoma, Masato Oikawa, Martin B. Gill, Geoffrey T. Swanson, Ryuichi Sakai, Keiko Shimamoto, Makoto Sasaki

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　(31)　5215-5220　2008/11

DOI： 10.1002/ejoc.200800704 　

ISSN： 1434-193X

P-34 Second-generation Total Synthesis of (-)-Brevenal(Poster Presentation)

EBINE Makoto, FUWA Haruhiko, SASAKI Makoto

Symposium on the Chemistry of Natural Products, symposium papers　(50)　641-646　2008/09/01

DOI： 10.24496/tennenyuki.50.0_641 　

P-72 Total Synthesis of Natural Products Based on Suzuki-Miyaura Coupling(Poster Presentation)

Fuwa Haruhiko, Naito Shinya, Goto Tomomi, Sasaki Makoto

Symposium on the Chemistry of Natural Products, symposium papers　(50)　755-760　2008/09/01

DOI： 10.24496/tennenyuki.50.0_755 　

TOTAL SYNTHESIS OF ISOINDOLOBENZAZEPINE ALKALOIDS, LENNOXAMINE AND CHILENINE, BASED ON PALLADIUM-CATALYZED REDUCTION OF ALKENYL PHOSPHATES Invited Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

HETEROCYCLES　76　(1)　521-539　2008/09

DOI： 10.3987/COM-08-S(N)40 　

ISSN： 0385-5414

A New Method for the Generation of Indole-2,3-quinodimethanes from Allenamides Peer-reviewed

Haruhiko Fuwa, Tomomi Tako, Makoto Ebine, Makoto Sasaki

CHEMISTRY LETTERS　37　(9)　904-905　2008/09

DOI： 10.1246/cl.2008.904 　

ISSN： 0366-7022

eISSN： 1348-0715

Total synthesis of (-)-brevenal: A concise synthetic entry to the pentacyclic polyether core Peer-reviewed

Makoto Ebine, Haruhiko Fuwa, Makoto Sasaki

ORGANIC LETTERS　10　(11)　2275-2278　2008/06

DOI： 10.1021/ol800685c 　

ISSN： 1523-7060

Stereocontrolled synthesis of the A/B-ring fragment of gambieric acid B: Reassignment of the absolute configuration of the polycyclic ether region Peer-reviewed

Haruhiko Fuwa, Tomomi Goto, Makoto Sasaki

ORGANIC LETTERS　10　(11)　2211-2214　2008/06

DOI： 10.1021/ol800642t 　

ISSN： 1523-7060

An efficient strategy for the synthesis of endocyclic enol ethers and its application to the synthesis of spiroacetals Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

ORGANIC LETTERS　10　(12)　2549-2552　2008/06

DOI： 10.1021/ol800815t 　

ISSN： 1523-7060

Polycavernosides and Gambierol: Invited Peer-reviewed

M. Carmen Louzao, Eva Cagide, Mari Yotsu-Yamashita, Makoto Sasaki

Chemistry, Pharmacology, Toxicology, and Detection, in Seafood and Freshwater Toxins: Pharmacology, Physiology and detection (Food Science and Technology) Editor, Louis M. Botana, Crc Pr I Llc　2008/04/10

DOI： 10.1002/9780470277874.ch15 　

Assignment of the absolute configuration of goniodomin A by NMR spectroscopy and synthesis of model compounds Peer-reviewed

Yoshiyuki Takeda, Jinglu Shi, Masato Oikawa, Makoto Sasaki

ORGANIC LETTERS　10　(5)　1013-1016　2008/03

DOI： 10.1021/ol8000377 　

ISSN： 1523-7060

Synthesis and domino metathesis of functionalized 7-oxanorbornene analogs toward cis-fused heterocycles Peer-reviewed

Minoru Ikoma, Masato Oikawa, Makoto Sasaki

TETRAHEDRON　64　(12)　2740-2749　2008/03

DOI： 10.1016/j.tet.2008.01.067 　

ISSN： 0040-4020

Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors Peer-reviewed

L. Leanne Lash, James M. Sanders, Nobuyuki Akiyama, Muneo Shoji, Pekka Postila, Olli T. Pentikainen, Makoto Sasaki, Ryuichi Sakai, Geoffrey T. Swanson

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　324　(2)　484-496　2008/02

DOI： 10.1124/jpet.107.129890 　

ISSN： 0022-3565

Rapid and efficient synthesis of dysiherbaine and analogues to explore structure - Activity relationships Peer-reviewed

Makoto Sasaki, Koichi Tsubone, Kunimori Aoki, Nobuyuki Akiyama, Muneo Shoji, Masato Oikawa, Ryuichi Sakai, Keiko Shimamoto

JOURNAL OF ORGANIC CHEMISTRY　73　(1)　264-273　2008/01

DOI： 10.1021/jo702116c 　

ISSN： 0022-3263

Convergent strategies for the total synthesis of polycyclic ether marine metabolites Invited Peer-reviewed

Makoto Sasaki, Haruhiko Fuwa

NATURAL PRODUCT REPORTS　25　(2)　401-426　2008

DOI： 10.1039/b705664h 　

ISSN： 0265-0568

Total synthesis of (+)-neopeltolide Peer-reviewed

Haruhiko Fuwa, Shinya Naito, Tomomi Goto, Makoto Sasaki

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　47　(25)　4737-4739　2008

DOI： 10.1002/anie.200801399 　

ISSN： 1433-7851

Total synthesis of dysiherbaine Peer-reviewed

Makoto Sasaki, Nobuyuki Akiyama, Koichi Tsubone, Muneo Shoji, Masato Oikawa, Ryuichi Sakai

TETRAHEDRON LETTERS　48　(32)　5697-5700　2007/08

DOI： 10.1016/j.tetlet.2007.05.180 　

ISSN： 0040-4039

Strategies for the synthesis of 2-substituted indoles and indolines starting from acyclic alpha-phosphoryloxy enecarbamates Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

ORGANIC LETTERS　9　(17)　3347-3350　2007/08

DOI： 10.1021/ol071312a 　

ISSN： 1523-7060

Convergent synthesis of the BCDEFGHIJ-ring polyether core of gambieric acids, potent antifungal polycyclic ethers Invited Peer-reviewed

Kazushi Sato, Makoto Sasaki

TETRAHEDRON　63　(26)　5977-6003　2007/06

DOI： 10.1016/j.tet.2007.02.039 　

ISSN： 0040-4020

A three-component approach to isoquinoline derivatives by cycloaddition/Heck reaction sequence Peer-reviewed

Masato Oikawa, Yoshiyuki Takeda, Shinya Naito, Daisuke Hashizume, Hiroyuki Koshino, Makoto Sasaki

TETRAHEDRON LETTERS　48　(24)　4255-4258　2007/06

DOI： 10.1016/j.tetlet.2007.04.082 　

ISSN： 0040-4039

Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors Peer-reviewed

Haruhiko Fuwa, Yasuko Takahashi, Yu Konno, Naoto Watanabe, Hiroyuki Miyashita, Makoto Sasaki, Hideaki Natsugari, Toshiyuki Kan, Tohru Fukuyama, Taisuke Tomita, Takeshi Iwatsubo

ACS CHEMICAL BIOLOGY　2　(6)　408-418　2007/06

DOI： 10.1021/cb700073y 　

ISSN： 1554-8929

Development and application of a convergent strategy for the total synthesis of polycyclic ether natural products Invited Peer-reviewed

Makoto Sasaki

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　80　(5)　856-871　2007/05

DOI： 10.1246/bcsj.80.856 　

ISSN： 0009-2673

eISSN： 1348-0634

Stereoselective synthesis of the AB-ring fragment of gambieric acid A Invited Peer-reviewed

Haruhiko Fuwa, Akihiro Suzuki, Kazushi Sato, Makoto Sasaki

HETEROCYCLES　72　139-144　2007/04

DOI： 10.3987/COM-06-S(K)30 　

ISSN： 0385-5414

A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

ORGANIC & BIOMOLECULAR CHEMISTRY　5　(14)　2214-2218　2007

DOI： 10.1039/b707338k 　

ISSN： 1477-0520

Total Synthesis and Structure—Activity Relationship of a Cytotoxic Polycyclic Ether Gymnocin-A Peer-reviewed

Chichiro Tsukano, Makoto Sasaki

ChemInform　38　(4)　2007/01

DOI： 10.1002/chin.200704251 　

Studies toward the total synthesis of gambieric acids A and C: Convergent assembly of the nonacyclic polyether skeleton Peer-reviewed

Kazushi Sato, Makoto Sasaki

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　46　(14)　2518-2522　2007

DOI： 10.1002/anie.200604625 　

ISSN： 1433-7851

An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

ORGANIC & BIOMOLECULAR CHEMISTRY　5　(12)　1849-1853　2007

DOI： 10.1039/b706087d 　

ISSN： 1477-0520

Skeletal diversity by ugi four-component coupling reaction and post-ugi reactions Invited Peer-reviewed

Masato Oikawa, Shinya Naito, Makoto Sasaki

Heterocycles　73　(C)　377-392　2007

DOI： 10.3987/COM-07-S(U)8 　

ISSN： 0385-5414

A new method for the generation of indole-2,3-quinodimethanes and 2-(N-alkoxycarbonylamino)-1,3-dienes. Intramolecular Heck/Diels Alder cycloaddition cascade starting from acyclic alpha-phosphono enecarbamates Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

CHEMICAL COMMUNICATIONS　(27)　2876-2878　2007

DOI： 10.1039/b704374k 　

ISSN： 1359-7345

A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides (Vol 5, pg 2214, 2007) Peer-reviewed

Haruhiko Fuwa, Makoto Sasaki

ORGANIC & BIOMOLECULAR CHEMISTRY　5　(15)　2506-2506　2007

DOI： 10.1039/b707338k 　

ISSN： 1477-0520

Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates Peer-reviewed

Haruhiko Fuwa, Akane Kaneko, Yasuaki Sugimoto, Taisuke Tomita, Takeshi Iwatsubo, Makoto Sasaki

HETEROCYCLES　70　101-+　2006/12

DOI： 10.3987/COM-06-S(W)30 　

ISSN： 0385-5414

Total synthesis, structure revision, and absolute configuration of (-)-brevenal Peer-reviewed

Haruhiko Fuwa, Makoto Ebine, Andrea J. Bourdelais, Daniel G. Baden, Makoto Sasaki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　128　(51)　16989-16999　2006/12

DOI： 10.1021/ja066772y 　

ISSN： 0002-7863

Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes Peer-reviewed

Makoto Sasaki, Koichi Tsubone, Muneo Shoji, Masato Okawa, Keiko Shimamoto, Ryuichi Sakai

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　16　(22)　5784-5787　2006/11

DOI： 10.1016/j.bmcl.2006.08.082 　

ISSN： 0960-894X

39 Total Synthesis and Structural Revision of Marine Polyether Natural Product Brevenal

Fuwa Haruhiko, Ebine Makoto, Ishioka Hiroki, Sasaki Makoto

Symposium on the Chemistry of Natural Products, symposium papers　(48)　229-234　2006/09/15

DOI： 10.24496/tennenyuki.48.0_229 　

P-46 Synthetic Study of Azaspiracid-1

Uehara Tomoko, Iwayama Taizo, Oikawa Masato, Sasaki Makoto

Symposium on the Chemistry of Natural Products, symposium papers　(48)　583-588　2006/09/15

DOI： 10.24496/tennenyuki.48.0_583 　

Effect of ciguatoxin 3C on voltage-gated Na+ and K+ currents in mouse taste cells Peer-reviewed

Valeria Ghiaroni, Haruhiko Fuwa, Masayuki Inoue, Makoto Sasaki, Keisuke Miyazaki, Masahiro Hirama, Takeshi Yasumoto, Gian Paolo Rossini, Giuseppe Scalera, Albertino Bigiani

CHEMICAL SENSES　31　(7)　673-680　2006/09

DOI： 10.1093/chemse/bjl008 　

ISSN： 0379-864X

Structure-activity relationship studies of gymnocin-A Peer-reviewed

Chihiro Tsukano, Makoto Sasaki

TETRAHEDRON LETTERS　47　(38)　6803-6807　2006/09

DOI： 10.1016/j.tetlet.2006.07.081 　

ISSN： 0040-4039

Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture Peer-reviewed

Makoto Sasaki, Naoki Takeda, Haruhiko Fuwa, Ryulchi Watanabe, Masayuki Satake, Yasukatsu Oshima

TETRAHEDRON LETTERS　47　(32)　5687-5691　2006/08

DOI： 10.1016/j.tetlet.2006.06.032 　

ISSN： 0040-4039

Total synthesis of the proposed structure of brevenal Peer-reviewed

Haruhiko Fuwa, Makoto Ebine, Makoto Sasaki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　128　(30)　9648-9650　2006/08

DOI： 10.1021/ja062524q 　

ISSN： 0002-7863

Synthetic study of azaspiracid-1: Synthesis of the EFGHI-ring fragment Peer-reviewed

Masato Oikawa, Tomoko Uehara, Taizo Iwayama, Makoto Sasaki

ORGANIC LETTERS　8　(18)　3943-3946　2006/08

DOI： 10.1021/ol0613766 　

ISSN： 1523-7060

P-545 DIVERGENT SYNTHESIS OF MOLECULAR PROBES BASED ON CAPROLACTAM γ-SECRETASE INHIBITORS AND THEIR MOLECULAR TARGETS

Fuwa Haruhiko, Takahashi Yasuko, Konno Yu, Sasaki Makoto, Kan Toshiyuki, Fukuyama Tohru, Natsugari Hideaki, Iwatsubo Takeshi, Tomita Taisuke

International Symposium on the Chemistry of Natural Products　2006　"P-545"　2006/07/23

DOI： 10.24496/intnaturalprod.2006.0__P-545_ 　

P-557 PROGRESS TOWARD TOTAL SYNTHESIS OF AZASPIRACID-1 : SYNTHESIS OF THE LOWER-HALF FRAGMENT

Oikawa Masato, Uehara Tomoko, Iwayama Taizo, Sasaki Makoto

International Symposium on the Chemistry of Natural Products　2006　"P-557"　2006/07/23

DOI： 10.24496/intnaturalprod.2006.0__P-557_ 　

P-561 TOTAL SYNTHESIS OF THE PROPOSED STRUCTURE OF BREVENAL

Fuwa Haruhiko, Ebine Makoto, Sasaki Makoto

International Symposium on the Chemistry of Natural Products　2006　"P-561"　2006/07/23

DOI： 10.24496/intnaturalprod.2006.0__P-561_ 　

P-512 ORGANIC SYNTHESIS FOR SKELETAL DIVERSITY, STARTING FROM UGI FOUR-COMPONENT COUPLING REACTION PRODUCTS

Oikawa Masato, Ikoma Minoru, Naito Shinya, Sasaki Makoto

International Symposium on the Chemistry of Natural Products　2006　"P-512"　2006/07/23

DOI： 10.24496/intnaturalprod.2006.0__P-512_ 　

Skeletal diversity by allylation/RCM on Ugi four-component coupling reaction products Peer-reviewed

Masato Oikawa, Shinya Naito, Makoto Sasaki

Tetrahedron Letters　47　(27)　4763-4767　2006/07/03

DOI： 10.1016/j.tetlet.2006.04.098 　

ISSN： 0040-4039

Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates Invited Peer-reviewed

Yasuko Takahashi, Haruhiko Fuwa, Akane Kaneko, Makoto Sasaki, Satoshi Yokoshima, Hifumi Koizumi, Tohru Takebe, Toshiyuki Kan, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari, Tohru Fukuyama

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　16　(14)　3813-3816　2006/07

DOI： 10.1016/j.bmcl.2006.04.025 　

ISSN： 0960-894X

eISSN： 1464-3405

Total synthesis and biological evaluation of neodysiherbaine A and analogues Peer-reviewed

Muneo Shoji, Nobuyuki Akiyama, Koichi Tsubone, L. Leanne Lash, James M. Sanders, Geoffrey T. Swanson, Ryuichi Sakai, Keiko Shimamoto, Masato Oikawa, Makoto Sasaki

JOURNAL OF ORGANIC CHEMISTRY　71　(14)　5208-5220　2006/07

DOI： 10.1021/jo0605593 　

ISSN： 0022-3263

Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors Peer-reviewed

JM Sanders, OT Pentikainen, L Settimo, U Pentikainen, M Shoji, M Sasaki, R Sakai, MS Johnson, GT Swanson

MOLECULAR PHARMACOLOGY　69　(6)　1849-1860　2006/06

DOI： 10.1124/mol.106.022772 　

ISSN： 0026-895X

The sodium channel of human excitable cells is a target for gambierol Peer-reviewed

M. Carmen Louzao, Eva Cagide, Mercedes R. Vieytes, Makoto Sasaki, Haruhiko Fuwa, Takeshi Yasumoto, Luis M. Botana

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY　17　(5-6)　257-268　2006

DOI： 10.1159/000094138 　

ISSN： 1015-8987

Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors Invited Peer-reviewed

JM Sanders, K Ito, L Settimo, OT Pentikainen, M Shoji, M Sasaki, MS Johnson, R Sakai, GT Swanson

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　314　(3)　1068-1078　2005/09

DOI： 10.1124/jpet.105.086389 　

ISSN： 0022-3565

Synthesis of dysiherbaine analogue Peer-reviewed

M Shoji, K Shiohara, M Oikawa, R Sakai, M Sasaki

TETRAHEDRON LETTERS　46　(33)　5559-5562　2005/08

DOI： 10.1016/j.tetlet.2005.06.093 　

ISSN： 0040-4039

Simultaneous accumulation of both skeletal and appendage-based diversities on tandem Ugi/Diels-Alder products Invited Peer-reviewed

M Oikawa, M Ikoma, M Sasaki

TETRAHEDRON LETTERS　46　(35)　5863-5866　2005/08

DOI： 10.1016/j.tetlet.2005.06.147 　

ISSN： 0040-4039

2-Oxo-1,2-ethylenedioxy group as a linker for solution-, liquid-, and solid-phase syntheses to discover drug-like small molecules Peer-reviewed

Masato Oikawa, Yoshiyuki Takeda, Makoto Sasaki

Tetrahedron Letters　46　(27)　4667-4670　2005/07/04

DOI： 10.1016/j.tetlet.2005.04.138 　

ISSN： 0040-4039

Synthesis of the NO ring model of gymnocin-B Peer-reviewed

C Tsukano, M Sasaki

TETRAHEDRON LETTERS　46　(27)　4617-4619　2005/07

DOI： 10.1016/j.tetlet.2005.04.140 　

ISSN： 0040-4039

Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: Convergent synthesis of the CDEFG-ring system Peer-reviewed

K Sato, M Sasaki

ORGANIC LETTERS　7　(12)　2441-2444　2005/06

DOI： 10.1021/ol050760k 　

ISSN： 1523-7060

Inhibition of voltage-gated potassium currents by gambierol in mouse taste cells Peer-reviewed

Ghiaroni, V, M Sasaki, H Fuwa, GP Rossini, G Scalera, T Yasumoto, P Pietra, A Bigiani

TOXICOLOGICAL SCIENCES　85　(1)　657-665　2005/05

DOI： 10.1093/toxsci/kfi097 　

ISSN： 1096-6080

Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues Peer-reviewed

C Tsukano, M Ebine, M Sasaki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　127　(12)　4326-4335　2005/03

DOI： 10.1021/ja042686r 　

ISSN： 0002-7863

Parallel synthesis of tandem Ugi/Diels-Alder reaction products on a soluble polymer support directed toward split-pool realization of a small molecule library Invited Peer-reviewed

M Oikawa, M Ikoma, M Sasaki

TETRAHEDRON LETTERS　46　(3)　415-418　2005/01

DOI： 10.1016/j.tetlet.2004.11.115 　

ISSN： 0040-4039

64(P-47) Diverted Total Synthesis and Biological Evaluation of Gambierol Analogues

Fuwa Haruhiko, Natsugari Hideaki, Kainuma Noriko, Tachibana Kazuo, Satake Masayuki, Sasaki Makoto

Symposium on the Chemistry of Natural Products, symposium papers　(46)　359-364　2004/10/01

DOI： 10.24496/tennenyuki.46.0_359 　

Diverted total synthesis and biological evaluation of gambierol analogues: Elucidation of crucial structural elements for potent toxicity Peer-reviewed

H Fuwa, N Kainuma, K Tachibana, C Tsukano, M Satake, M Sasaki

CHEMISTRY-A EUROPEAN JOURNAL　10　(19)　4894-4909　2004/10

DOI： 10.1002/chem.200400355 　

ISSN： 0947-6539

Convergent synthesis of the ABCDE ring fragment of ciguatoxins Peer-reviewed

H Fuwa, S Fujikawa, K Tachibana, H Takakura, M Sasaki

TETRAHEDRON LETTERS　45　(24)　4795-4799　2004/06

DOI： 10.1016/j.tetlet.2004.04.083 　

ISSN： 0040-4039

Synthesis of the CDE/FG ring models of prymnesins: Reassignment of the relative configuration of the E/F ring juncture Peer-reviewed

M Sasaki, M Ebine, H Takagi, H Takakura, T Shida, M Satake, Y Oshima, T Igarashi, T Yasumoto

ORGANIC LETTERS　6　(9)　1501-1504　2004/04

DOI： 10.1021/ol049569l 　

ISSN： 1523-7060

Alkoxyacetyl (AAc) group as a useful linker for organic synthesis on poly(ethylene glycol) support Peer-reviewed

M Oikawa, M Ikoma, M Sasaki

TETRAHEDRON LETTERS　45　(11)　2371-2375　2004/03

DOI： 10.1016/j.tetlet.2004.01.103 　

ISSN： 0040-4039

Simple formylacetal (CH2) as a novel linker for saccharide synthesis on soluble-polymer support Peer-reviewed

M Oikawa, T Tanaka, S Kusomoto, M Sasaki

TETRAHEDRON LETTERS　45　(4)　787-790　2004/01

DOI： 10.1016/j.tetlet.2003.11.036 　

ISSN： 0040-4039

Pathological effects on mice by gambierol, possibly one of the ciguatera toxins Peer-reviewed

E Ito, F Suzuki-Toyota, K Toshimori, H Fuwa, K Tachibana, M Satake, M Sasaki

TOXICON　42　(7)　733-740　2003/12

DOI： 10.1016/j.toxicon.2003.09.011 　

ISSN： 0041-0101

Total synthesis of gymnocin-A Invited Peer-reviewed

C Tsukano, M Sasaki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　125　(47)　14294-14295　2003/11

DOI： 10.1021/ja038547b 　

ISSN： 0002-7863

Synthesis Entry to the ABCD Ring Fragment of Gymnocin-A, a Cytotoxic Marine Polyether. Peer-reviewed

Makoto Sasaki, Chihiro Tsukano, Kazuo Tachibana

ChemInform　34　(34)　2003/08

DOI： 10.1002/chin.200334213 　

Studies toward the total synthesis of azaspiracids: synthesis of the FGHI ring domain Peer-reviewed

M Sasaki, Y Iwamuro, J Nemoto, M Oikawa

TETRAHEDRON LETTERS　44　(33)　6199-6201　2003/08

DOI： 10.1016/S0040-4039(03)01553-3 　

ISSN： 0040-4039

Synthesis and biological evaluation of gambierol analogues Peer-reviewed

H Fuwa, N Kainuma, M Satake, M Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　13　(15)　2519-2522　2003/08

DOI： 10.1016/S0960-894X(03)00467-0 　

ISSN： 0960-894X

Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether Peer-reviewed

M Sasaki, C Tsukano, K Tachibana

TETRAHEDRON LETTERS　44　(23)　4351-4354　2003/06

DOI： 10.1016/S0040-4039(03)00949-3 　

ISSN： 0040-4039

Total synthesis of (-)-gambierol Peer-reviewed

H Fuwa, N Kainuma, K Tachibana, M Sasaki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　124　(50)　14983-14992　2002/12

DOI： 10.1021/ja028167a 　

ISSN： 0002-7863

27 Total Synthesis of Gambierol

Fuwa Haruhiko, Sasaki Makoto, Tachibana Kazuo

Symposium on the Chemistry of Natural Products, symposium papers　(44)　157-162　2002/09/01

DOI： 10.24496/tennenyuki.44.0_157 　

Total synthesis of gambierol Peer-reviewed

H Fuwa, M Sasaki, M Satake, K Tachibana

ORGANIC LETTERS　4　(17)　2981-2984　2002/08

DOI： 10.1021/o1026394b 　

ISSN： 1523-7060

Progress toward the total synthesis of ciguatoxins: A convergent synthesis of the FGHIJKLM ring fragment Peer-reviewed

H Takakura, M Sasaki, S Honda, K Tachibana

ORGANIC LETTERS　4　(16)　2771-2774　2002/08

DOI： 10.1021/ol026306n 　

ISSN： 1523-7060

Studies toward the total synthesis of gymnocin A, a cytotoxic polyether: A highly convergent entry to the F-N ring fragment Peer-reviewed

M Sasaki, C Tsukano, K Tachibana

ORGANIC LETTERS　4　(10)　1747-1750　2002/05

DOI： 10.1021/ol025814u 　

ISSN： 1523-7060

Intramolecular radical cyclization - Ring-closing metathesis approach to fused polycyclic ethers. Convergent synthesis and conformational analysis of the (E)FGH ring system of ciguatoxin Peer-reviewed

M Sasaki, T Noguchi, K Tachibana

JOURNAL OF ORGANIC CHEMISTRY　67　(10)　3301-3310　2002/05

DOI： 10.1021/jo010974p 　

ISSN： 0022-3263

A general strategy for the convergent synthesis of fused polycyclic ethers via B-alkyl Suzuki coupling: synthesis of the ABCD ring fragment of ciguatoxins Invited Peer-reviewed

M Sasaki, M Ishikawa, H Fuwa, K Tachibana

TETRAHEDRON　58　(10)　1889-1911　2002/03

DOI： 10.1016/S0040-4020(02)00045-5 　

ISSN： 0040-4020

Synthetic studies toward gambierol. Convergent synthesis of the octacyclic polyether core Peer-reviewed

H Fuwa, M Sasaki, K Tachibana

ORGANIC LETTERS　3　(22)　3549-3552　2001/11

DOI： 10.1021/ol0166597 　

ISSN： 1523-7060

Synthesis and stereochemical confirmation of the HI/JK ring system of prymnesins, potent hemolytic and ichthyotoxic glycoside toxins isolated from the red tide alga Peer-reviewed

M Sasaki, T Shida, K Tachibana

TETRAHEDRON LETTERS　42　(33)　5725-5728　2001/08

DOI： 10.1016/S0040-4039(01)01067-X 　

ISSN： 0040-4039

Isolation, structure determination, and synthesis of neodysiherbaine A, a new excitatory amino acid from a marine sponge Peer-reviewed

R Sakai, T Koike, M Sasaki, K Shimamoto, C Oiwa, A Yano, K Suzuki, K Tachibana, H Kamiya

ORGANIC LETTERS　3　(10)　1479-1482　2001/05

DOI： 10.1021/ol015798l 　

ISSN： 1523-7060

Synthetic studies on a marine polyether toxin, gambierol: stereoselective synthesis of the EFGH ring system via B-alkyl Suzuki coupling Peer-reviewed

H Fuwa, M Sasaki, K Tachibana

TETRAHEDRON　57　(15)　3019-3033　2001/04

DOI： 10.1016/S0040-4020(01)00164-8 　

ISSN： 0040-4020

Synthetic studies on ciguatoxin: A highly convergent synthesis of the GHIJKLM ring system based on B-alkyl Suzuki coupling Peer-reviewed

H Takakura, K Noguchi, M Sasaki, K Tachibana

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　40　(6)　1090-+　2001

DOI： 10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W 　

ISSN： 1433-7851

Synthetic studies on a marine polyether toxin, gambierol: stereoselective synthesis of the FGH ring system via B-alkyl Suzuki coupling Peer-reviewed

H Fuwa, M Sasaki, K Tachibana

TETRAHEDRON LETTERS　41　(43)　8371-8375　2000/10

ISSN： 0040-4039

A Convergent Synthesis of the Decacyclic Ciguatoxin Model Containing the F−M Ring Framework

Masayuki Inoue, Makoto Sasaki, Kazuo Tachibana

The Journal of Organic Chemistry　64　(26)　9416-9429　1999/12

DOI： 10.1021/jo990989b 　

ISSN： 0022-3263

eISSN： 1520-6904

Stereocontrolled Synthesis of the JKLM Ring Fragment of Ciguatoxin

Makoto Sasaki, Masayuki Inoue, Kuniyuki Takamatsu, Kazuo Tachibana

The Journal of Organic Chemistry　64　(26)　9399-9415　1999/12

DOI： 10.1021/jo990988j 　

ISSN： 0022-3263

eISSN： 1520-6904

A general method for convergent synthesis of polycyclic ethers based on Suzuki cross-coupling: Concise synthesis of the ABCD ring system of ciguatoxin Peer-reviewed

M Sasaki, H Fuwa, M Ishikawa, K Tachibana

ORGANIC LETTERS　1　(7)　1075-1077　1999/10

ISSN： 1523-7060

A convergent synthesis of the trans-fused hexahydrooxonine ring system and reproduction of conformational behavior shown by ring F of ciguatoxin

Masayuki Inoue, Makoto Sasaki, Kazuo Tachibana

Tetrahedron　55　(36)　10949-10970　1999/09

DOI： 10.1016/s0040-4020(99)00620-1 　

ISSN： 0040-4020

Convergent and stereoselective method for synthesis of O -linked oxepane ring system by intramolecular radical cyclization

Makoto Sasaki, Masayuki Inoue, Tetsuji Noguchi, Atsuo Takeichi, Kazuo Tachibana

Tetrahedron Letters　39　(18)　2783-2786　1998/04

DOI： 10.1016/s0040-4039(98)00338-4 　

ISSN： 0040-4039

Structural Elucidation of Organic Molecules by Mass Spectrometry

SASAKI Makoto

CHEMISTRY & EDUCATION　46　(11)　730-734　1998

DOI： 10.20665/kakyoshi.46.11_730 　

ISSN： 0386-2151

Inhibition of maitotoxin-induced Ca²⁺ influx in rat glioma C6 cells by brevetoxins and synthetic fragments of maitotoxin

Keiichi Konoki, Masaki Hashimoto, Taro Nonomura, Makoto Sasaki, Michio Murata, Michio Murata, Kazuo Tachibana

Journal of Neurochemistry　70　409-416　1998/01/01

ISSN： 0022-3042

19 SYNTHESIS AND CONFORMATIONAL ANALYSIS OF THE NINE-MEMBERED ETHER RING SYSTEM OF CIGUATOXIN

Inoue Masayuki, Sasaki Makoto, Tachibana Kazuo

Symposium on the Chemistry of Natural Products, symposium papers　(39)　109-114　1997/07/20

DOI： 10.24496/tennenyuki.39.0_109 　

Construction of fused oxonene ring and reproduction of conformational behavior shown by ring F of ciguatoxin

Masayuki Inoue, Makoto Sasaki, Kazuo Tachibana

Tetrahedron Letters　38　(9)　1611-1614　1997/03

DOI： 10.1016/s0040-4039(97)00125-1 　

ISSN： 0040-4039

27 THE COMPLETE STRUCTURE OF MAITOTOXIN

Sasaki Makoto, Nonomura Taro, Matsumori Nobuaki, Maruyama Takahiro, Murata Michio, Tachibana Kazuo, Yasumoto Takeshi

Symposium on the Chemistry of Natural Products, symposium papers　(38)　157-162　1996/09/02

DOI： 10.24496/tennenyuki.38.0_157 　

Long-range carbon-proton coupling constants for stereochemical assignment of acyclic structures in natural products: Configuration of the C5-C9 portion of maitotoxin

N Matsumori, T Nonomura, M Sasaki, M Murata, K Tachibana, M Satake, T Yasumoto

TETRAHEDRON LETTERS　37　(8)　1269-1272　1996/02

DOI： 10.1016/0040-4039(95)02413-1 　

ISSN： 0040-4039

The Complete Structure of Maitotoxin, Part II: Configuration of the C135-C142 Side Chain and Absolute Configuration of the Entire Molecule

Taro Nonomura, Makoto Sasaki, Nobuaki Matsumori, Michio Murata, Kazuo Tachibana, Takeshi Yasumoto

Angewandte Chemie (International Edition in English)　35　(15)　1675-1678　1996

DOI： 10.1002/anie.199616751 　

ISSN： 0570-0833

The Complete Structure of Maitotoxin, Part I: Configuration of the C1-C14 Side Chain

Makoto Sasaki, Nobuaki Matsumori, Takahiro Maruyama, Taro Nonomura, Michio Murata, Kazuo Tachibana, Takeshi Yasumoto

Angewandte Chemie (International Edition in English)　35　(15)　1672-1675　1996

DOI： 10.1002/anie.199616721 　

ISSN： 0570-0833

SYNTHETIC APPROACH TOWARD COMPLETE STRUCTURE DETERMINATION OF MAITOTOXIN - STEREOCHEMICAL ASSIGNMENT OF THE C63-C68 ACYCLIC LINKAGE

M SASAKI, T NONOMURA, M MURATA, K TACHIBANA

TETRAHEDRON LETTERS　36　(49)　9007-9010　1995/12

DOI： 10.1016/0040-4039(95)01972-K 　

ISSN： 0040-4039

STEREOCHEMICAL ASSIGNMENT OF THE C35-C39 ACYCLIC LINKAGE IN MAITOTOXIN - COMPLETION OF STEREOCHEMICAL DETERMINATION OF C15-C134

M SASAKI, N MATSUMORI, M MURATA, K TACHIBANA, T YASUMOTO

TETRAHEDRON LETTERS　36　(49)　9011-9014　1995/12

DOI： 10.1016/0040-4039(95)01973-L 　

ISSN： 0040-4039

21 SYNTHETIC STUDIES TOWARD COMPLETE STEREOSTRUCTURE OF MAITOTOXIN

SASAKI Makoto, NONOMURA Taro, MATSUMORI Nobuaki, MURATA Michio, TACHIBANA Kazuo, YASUMOTO Takeshi

Symposium on the Chemistry of Natural Products, symposium papers　(37)　121-126　1995/09/01

DOI： 10.24496/tennenyuki.37.0_121 　

P-42 SYNTHETIC AND SPECTROSCOPIC STUDIES ON STEREOSTRUCTURE OF MAITOTOXIN

Sasaki Makoto, Nonomura Taro, Matsumori Nobuaki, Murata Michio, Tachibana Kazuo, Satake Masayuki, Ishida Shu, Yasumoto Takeshi

Symposium on the Chemistry of Natural Products, symposium papers　(36)　705-712　1994/09/20

DOI： 10.24496/tennenyuki.36.0_705 　

SYNTHESIS AND STEREOCHEMICAL CONFIRMATION OF THE CIS-FUSED L/M AND N/O RING-SYSTEMS OF MAITOTOXIN

M SASAKI, T NONOMURA, M MURATA, K TACHIBANA

TETRAHEDRON LETTERS　35　(28)　5023-5026　1994/07

DOI： 10.1016/S0040-4039(00)73310-7 　

ISSN： 0040-4039

Synthetic Studies toward Ciguatoxin. Stereocontrolled Construction of the KLM Ring Fragment

Makoto Sasaki, Masayuki Inoue, Kazuo Tachibana

The Journal of Organic Chemistry　59　(4)　715-717　1994/02

DOI： 10.1021/jo00083a008 　

ISSN： 0022-3263

eISSN： 1520-6904

STRUCTURE OF MAITOTOXIN

M MURATA, H NAOKI, T IWASHITA, S MATSUNAGA, M SASAKI, A YOKOYAMA, T YASUMOTO

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　115　(5)　2060-2062　1993/03

DOI： 10.1021/ja00058a075 　

ISSN： 0002-7863

Membrane perturbation of pardaxins, defensive peptides of flatfish.

Keiichi Konoki, Makoto Sasaki, Kazuo Tachibana

Peptide Chemistry 1992: Proceedings of the 2nd Japan Symposium on Peptide Chemistry　402-405　1993

Partial structures and binding studies of maitotoxin, the most potent marine toxin.

M. Murata, M. Sasaki, A. Yokoyama, T. Iwashita, F. Gusovsky, J. W. Daly, T. Yasumoto

Bulletin de la Societe de pathologie exotique (1990)　85　470-473　1992/12/01

EFFECT OF MAITOTOXIN ANALOGS ON CALCIUM INFLUX AND PHOSPHOINOSITIDE BREAKDOWN IN CULTURED-CELLS

M MURATA, F GUSOVSKY, M SASAKI, A YOKOYAMA, T YASUMOTO, JW DALY

TOXICON　29　(9)　1085-1096　1991

DOI： 10.1016/0041-0101(91)90206-7 　

ISSN： 0041-0101