Details of the Researcher

PHOTO

Mika Sakurai
Section
Tohoku Medical Megabank Organization
Job title
Associate Professor
Degree

  • 博士（医学）（東京大学）

  • 修士（工学）（東京理科大学）

e-Rad No.
80508359

Research History 8

  • 2018/03 - Present
    Tohoku University　Tohoku Medical Megabank Organization

  • 2017/04 - 2018/02
    Tohoku University　Tohoku Medical Megabank Organization

  • 2015/04 - 2017/03
    日本医療研究開発機構　主幹

  • 2013/09 - 2015/03
    Tohoku University　Tohoku Medical Megabank Organization

  • 2007/11 - 2013/08
    The University of Tokyo　The Institute of Medical Science

  • 2007/09 - 2007/11
    The University of Tokyo　The Institute of Medical Science

  • 2005/04 - 2007/08
    キュリー研究所　ポストドクトラルフェロー

  • 2003/04 - 2005/03
    国立がんセンター研究所　リサーチレジデント

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Education 3

  • The University of Tokyo

    1999/04 - 2003/03

  • Tokyo University of Science　Graduate School of Industrial Science and Technology

    1997/04 - 1999/03

  • Tokyo University of Science　Faculty of Industrial Science and Technology

    1993/04 - 1997/03

Professional Memberships 3

  • THE JAPAN SOCIETY OF HUMAN GENETICS

  • THE JAPANESE CANCER ASSOCIATION

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Interests 5

  • ゲノム医療

  • 細胞接着

  • 細胞浸潤

  • 細胞外マトリックス

  • Molecular and Cellular Biology

Research Areas 3

  • Life sciences / Molecular biology /

  • Life sciences / Cell biology /

  • Life sciences / Genomics /

Papers 48

  1. The Health History of First-Degree Relatives’ Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia Peer-reviewed

    Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Kayono Yamamoto, Yasushi Ishigaki, HIROSHI KAWAME, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Akira Uruno, Kichiya Suzuki, Kozo Tanno, Hideki Ohmomo, Atsushi Shimizu, Masayuki Yamamoto, Makoto Sasaki

    Genes　2024/03/21

    DOI： 10.3390/genes15030384 　

  2. Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS) Peer-reviewed

    Sei Harada, Miho Iida, Naoko Miyagawa, Aya Hirata, Kazuyo Kuwabara, Minako Matsumoto, Tomonori Okamura, Shun Edagawa, Yoko Kawada, Atsuko Miyake, Ryota Toki, Miki Akiyama, Atsuki Kawai, Daisuke Sugiyama, Yasunori Sato, Ryo Takemura, Kota Fukai, Yoshiki Ishibashi, Suzuka Kato, Ayako Kurihara, Mizuki Sata, Takuma Shibuki, Ayano Takeuchi, Shun Kohsaka, Mitsuaki Sawano, Satoshi Shoji, Yoshikane Izawa, Masahiro Katsumata, Koichi Oki, Shinichi Takahashi, Tsubasa Takizawa, Hiroshi Maruya, Yuji Nishiwaki, Ryo Kawasaki, Akiyoshi Hirayama, Takamasa Ishikawa, Rintaro Saito, Asako Sato, Tomoyoshi Soga, Masahiro Sugimoto, Masaru Tomita, Shohei Komaki, Hideki Ohmomo, Kanako Ono, Yayoi Otsuka-Yamasaki, Atsushi Shimizu, Yoichi Sutoh, Atsushi Hozawa, Kengo Kinoshita, Seizo Koshiba, Kazuki Kumada, Soichi Ogishima, Mika Sakurai-Yageta, Gen Tamiya, Toru Takebayashi

    Journal of Epidemiology　2024/01

    Publisher: Japan Epidemiological Association

    DOI： 10.2188/jea.je20230192 　

    ISSN： 0917-5040

    eISSN： 1349-9092

  3. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project.

    Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Tomomi Onuma, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Akira Uruno, Junichi Sugawara, Kichiya Suzuki, Eiichi N Kodama, Yohei Hamanaka, Naho Tsuchiya, Mana Kogure, Naoki Nakaya, Makiko Taira, Mika Sakurai-Yageta, Toru Tamahara, Junko Kawashima, Maki Goto, Akihito Otsuki, Ritsuko Shimizu, Soichi Ogishima, Hiroaki Hashizume, Fuji Nagami, Tomohiro Nakamura, Atsushi Hozawa, Tadao Kobayashi, Nobuo Fuse, Shinichi Kuriyama, Shigeo Kure, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　259　(2)　93-105　2023/01/20

    DOI： 10.1620/tjem.2022.J103 　

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    The Tohoku Medical Megabank Project (TMM) has been conducting a birth and three-generation cohort study (the BirThree Cohort Study). We recruited 73,529 pregnant women and their family members for this cohort study, which included 23,143 newborns and 9,459 of their siblings. We designed and are in the process of conducting three-step health assessments for each newborn at approximately ages of 5, 10 and 16. These health assessments are administered at seven community support centers. Trained genome medical research coordinators conduct physical examinations of and collect biological specimens from each participant. The Sendai Children's Health Square has been established as the headquarters for these child health assessments and is utilized to accumulate knowledge that can facilitate the proper practice of child health assessments. We designed all the relevant health assessments facilities to allow parents and their children to participate in the health assessments concomitantly. Our centers serve as places where child participants and their parents can feel at ease as a result of the implementation of safety measures and child hospitality measures. The TMM BirThree Cohort Study is in the process of conducting strategically detailed health assessments and genome analysis, which can facilitate studies concerning the gene-environment interactions relevant to noncommunicable diseases. Through these operations, our study allows for a significant depth of data to be collected in terms of the number of biospecimens under study and the comprehensiveness of both basic and clinical data alongside relevant family information.

  4. Trans-homophilic interaction of CADM1 promotes organ infiltration of T-cell lymphoma by adhesion to vascular endothelium. International-journal

    Yutaka Kasai, Siew Pey Gan, Toko Funaki, Yuki Ohashi-Kumagai, Mizuki Tominaga, Shu-Jen Shiu, Daisuke Suzuki, Daisuke Matsubara, Takeharu Sakamoto, Mika Sakurai-Yageta, Takeshi Ito, Yoshinori Murakami

    Cancer science　113　(5)　1669-1678　2022/05

    DOI： 10.1111/cas.15307 　

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    The initial step of organ infiltration of malignant cells is the interaction with host vascular endothelial cells, which is often mediated by specific combinations of cell adhesion molecules. Cell adhesion molecule 1 (CADM1) is overexpressed in adult T-cell leukemia/lymphoma (ATL) and provides a cell-surface diagnostic marker. CADM1 promotes the adhesion of ATL cells to vascular endothelial cells and multiple organ infiltration in mice. However, its binding partner on host cells has not yet been identified. In this study, we show that CADM1 promotes transendothelial migration of ATL cells in addition to the adhesion to vascular endothelial cells. Moreover, CADM1 enhances liver infiltration of mouse T-cell lymphoma cells, EL4, after tail vein injection, whereas a CADM1 mutant lacking adhesive activity did not. Among the known CADM1-binding proteins expressed in primary endothelial cells, only CADM1 and CADM4 could induce morphological extension of ATL cells when plated onto glass coated with these proteins. Furthermore, CADM1-mediated liver infiltration of EL4 cells was canceled in conventional and vascular endothelium-specific Cadm1 knockout mice, whereas it was not canceled in Cadm4 knockout mice. These results suggest that CADM1 on host vascular endothelial cells is required for organ infiltration of ATL and other T-cell lymphomas expressing CADM1.

  5. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants.

    Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, Yoichi Suzuki, Kichiya Suzuki, Akira Uruno, Mika Sakurai-Yageta, Yohei Hamanaka, Makiko Taira, Soichi Ogishima, Shinichi Kuriyama, Atsushi Hozawa, Hiroaki Tomita, Naoko Minegishi, Junichi Sugawara, Inaho Danjoh, Tomohiro Nakamura, Tomoko Kobayashi, Yumi Yamaguchi-Kabata, Shu Tadaka, Taku Obara, Eiji Hishimuma, Nariyasu Mano, Masaki Matsuura, Yuji Sato, Masateru Nakasone, Yohei Honkura, Jun Suzuki, Yukio Katori, Yoichi Kakuta, Atsushi Masamune, Yoko Aoki, Masaharu Nakayama, Shigeo Kure, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto

    JMA journal　5　(2)　177-189　2022/04/15

    DOI： 10.31662/jmaj.2021-0156 　

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    Introduction: Pharmacogenomic (PGx) testing results provide valuable information on drug selection and appropriate dosing, maximization of efficacy, and minimization of adverse effects. Although the number of large-scale, next-generation-sequencing-based PGx studies has recently increased, little is known about the risks and benefits of returning PGx results to ostensibly healthy individuals in research settings. Methods: Single-nucleotide variants of three actionable PGx genes, namely, MT-RNR1, CYP2C19, and NUDT15, were returned to 161 participants in a population-based Tohoku Medical Megabank project. Informed consent was obtained from the participants after a seminar on the outline of this study. The results were sent by mail alongside sealed information letter intended for clinicians. As an exception, genetic counseling was performed for the MT-RNR1 m.1555A > G variant carriers by a medical geneticist, and consultation with an otolaryngologist was encouraged. Questionnaire surveys (QSs) were conducted five times to evaluate the participants' understanding of the topic, psychological impact, and attitude toward the study. Results: Whereas the majority of participants were unfamiliar with the term PGx, and none had undergone PGx testing before the study, more than 80% of the participants felt that they could acquire basic PGx knowledge sufficient to understand their genomic results and were satisfied with their potential benefit and use in future prescriptions. On the other hand, some felt that the PGx concepts or terminology was difficult to fully understand and suggested that in-person return of the results was desirable. Conclusions: These results collectively suggest possible benefits of returning preemptive PGx information to ostensibly healthy cohort participants in a research setting.

  6. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. International-journal

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    Human genome variation　8　(1)　44-44　2021/12/10

    DOI： 10.1038/s41439-021-00175-5 　

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    To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

  7. Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference

    Jun Takayama, Shu Tadaka, Kenji Yano, Fumiki Katsuoka, Chinatsu Gocho, Takamitsu Funayama, Satoshi Makino, Yasunobu Okamura, Atsuo Kikuchi, Sachiyo Sugimoto, Junko Kawashima, Akihito Otsuki, Mika Sakurai-Yageta, Jun Yasuda, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto, Gen Tamiya

    Nature Communications　12　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41467-020-20146-8 　

    eISSN： 2041-1723

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    <title>Abstract</title>The complete human genome sequence is used as a reference for next-generation sequencing analyses. However, some ethnic ancestries are under-represented in the reference genome (e.g., GRCh37) due to its bias toward European and African ancestries. Here, we perform de novo assembly of three Japanese male genomes using &gt; 100× Pacific Biosciences long reads and Bionano Genomics optical maps per sample. We integrate the genomes using the major allele for consensus and anchor the scaffolds using genetic and radiation hybrid maps to reconstruct each chromosome. The resulting genome sequence, JG1, is contiguous, accurate, and carries the Japanese major allele at most loci. We adopt JG1 as the reference for confirmatory exome re-analyses of seven rare-disease Japanese families and find that re-analysis using JG1 reduces total candidate variant calls versus GRCh37 while retaining disease-causing variants. These results suggest that integrating multiple genomes from a single population can aid genome analyses of that population.

  8. Association between Serum Biotin Levels and Cedar Pollinosis in Japanese Schoolchildren

    Mika SAKURAI-YAGETA, Yoichi MASHIMO, Toshinobu KUROISHI, Rino ISHIHARA, Naoki SHIMOJO, Yoichi KOHNO, Yoshitaka OKAMOTO, Akira HATA, Yoichi SUZUKI

    Journal of Nutritional Science and Vitaminology　67　(4)　211-216　2021/08/31

    Publisher: Center for Academic Publications Japan

    DOI： 10.3177/jnsv.67.211 　

    ISSN： 0301-4800

    eISSN： 1881-7742

  9. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. International-journal

    Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Jun Yasuda, Yumi Yamaguchi-Kabata, Kengo Kinoshita, Soichi Ogishima, Takako Takai, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naoko Minegishi, Junichi Sugawara, Kichiya Suzuki, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Yayoi Aizawa, Tomoharu Tokutomi, Kayono Yamamoto, Kinuko Ohneda, Shigeo Kure, Yoko Aoki, Hideki Katagiri, Yasushi Ishigaki, Shojiro Sawada, Makoto Sasaki, Masayuki Yamamoto

    Journal of human genetics　67　(1)　9-17　2021/07/08

    DOI： 10.1038/s10038-021-00952-8 　

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    Certain large genome cohort studies attempt to return the individual genomic results to the participants; however, the implementation process and psychosocial impacts remain largely unknown. The Tohoku Medical Megabank Project has conducted large genome cohort studies of general residents. To implement the disclosure of individual genomic results, we extracted the potential challenges and obstacles. Major challenges include the determination of genes/disorders based on the current medical system in Japan, the storage of results, prevention of misunderstanding, and collaboration of medical professionals. To overcome these challenges, we plan to conduct multilayer pilot studies, which deal with different disorders/genes. We finally chose familial hypercholesterolemia (FH) as a target disease for the first pilot study. Of the 665 eligible candidates, 33.5% were interested in the pilot study and provided consent after an educational "genetics workshop" on the basic genetics and medical facts of FH. The genetics professionals disclosed the results to the participants. All positive participants were referred to medical care, and a serial questionnaire revealed no significant psychosocial distress after the disclosure. Return of genomic results to research participants was implemented using a well-prepared protocol. To further elucidate the impact of different disorders, we will perform multilayer pilot studies with different disorders, including actionable pharmacogenomics and hereditary tumor syndromes.

  10. Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs

    Mika Sakurai-Yageta, Kazuki Kumada, Chinatsu Gocho, Satoshi Makino, Akira Uruno, Shu Tadaka, Ikuko N Motoike, Masae Kimura, Shin Ito, Akihito Otsuki, Akira Narita, Hisaaki Kudo, Yuichi Aoki, Inaho Danjoh, Jun Yasuda, Hiroshi Kawame, Naoko Minegishi, Seizo Koshiba, Nobuo Fuse, Gen Tamiya, Masayuki Yamamoto, Kengo Kinoshita

    The Journal of Biochemistry　2021/05/13

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/jb/mvab060 　

    ISSN： 0021-924X

    eISSN： 1756-2651

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    <title>Abstract</title> Ethnic-specific SNP arrays are becoming more important to increase the power of genome-wide association studies in diverse population. In the Tohoku Medical Megabank Project, we have been developing a series of Japonica Arrays (JPA) for genotyping participants based on reference panels constructed from whole-genome sequence data of the Japanese population. Here, we designed a novel version of the SNP array for the Japanese population, called Japonica Array NEO (JPA NEO), comprising a total of 666,883 markers. Among them, 654,246 tag SNPs of autosomes and X chromosome were selected from an expanded reference panel of 3,552 Japanese, 3.5KJPNv2, using pairwise r2 of linkage disequilibrium measures. Additionally, 28,298 markers were included for the evaluation of previously identified disease risk markers from the literature and databases, and those present in the Japanese population were extracted using the reference panel. Through genotyping 286 Japanese samples, we found that the imputation quality r2 and INFO score in the minor allele frequency bin &amp;gt;2.5–5% were &amp;gt;0.9 and &amp;gt;0.8, respectively, and &amp;gt;12 million markers were imputed with an INFO score &amp;gt;0.8. From these results, JPA NEO is a promising tool for genotyping the Japanese population with genome-wide coverage, contributing to the development of genetic risk scores.

  11. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project

    Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, Akihito Otsuki, Junko Kawashima, Tomomi Kiyama, Toru Tamahara, Maki Goto, Shihoko Koyama, Junichi Sugawara, Eiichi N. Kodama, Hirohito Metoki, Atsushi Hozawa, Shinichi Kuriyama, Hiroaki Tomita, Masahiro Kikuya, Naoko Minegishi, Kichiya Suzuki, Seizo Koshiba, Gen Tamiya, Nobuo Fuse, Yuichi Aoki, Takako Takai-Igarashi, Soichi Ogishima, Tomohiro Nakamura, Mika Sakurai-Yageta, Fuji Nagami, Kengo Kinoshita, Shigeo Kure, Ritsuko Shimizu, Keiichi Sasaki, Masayuki Yamamoto

    The Tohoku Journal of Experimental Medicine　251　(2)　97-115　2020

    DOI： 10.1620/tjem.251.97 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  12. Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. International-journal Peer-reviewed

    Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A, Nishizuka SS, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Takezaki T, Suzuki S, Naito M, Wakai K, Kamatani Y, Momozawa Y, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y

    Scientific reports　9　(1)　17332-17332　2019/11

    DOI： 10.1038/s41598-019-53654-9 　

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    Genome-wide association studies (GWAS) have successfully identified about 70 genomic loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and environmental exposures in different populations, it is essential to perform regional GWAS for better risk prediction. This study aimed to investigate the genetic architecture and to assess common genetic risk model of breast cancer with 6,669 breast cancer patients and 21,930 female controls in the Japanese population. This GWAS identified 11 genomic loci that surpass genome-wide significance threshold of P < 5.0 × 10-8 with nine previously reported loci and two novel loci that include rs9862599 on 3q13.11 (ALCAM) and rs75286142 on 21q22.12 (CLIC6-RUNX1). Validation study was carried out with 981 breast cancer cases and 1,394 controls from the Aichi Cancer Center. Pathway analyses of GWAS signals identified association of dopamine receptor medicated signaling and protein amino acid deacetylation with breast cancer. Weighted genetic risk score showed that individuals who were categorized in the highest risk group are approximately 3.7 times more likely to develop breast cancer compared to individuals in the lowest risk group. This well-powered GWAS is a representative study to identify SNPs that are associated with breast cancer in the Japanese population.

  13. Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project. Peer-reviewed

    Fuse N, Sakurai-YagetaM, Katsuoka F, Danjoh I, Shimizu R, Tamiya G, Nagami F, Kawame H, Higuchi S, Kinoshita K, Kure S, Yamamoto M

    JMA Journal　2　(2)　113-122　2019/09

    DOI： 10.31662/jmaj.2019-0014. 　

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    The Tohoku Medical Megabank (TMM) project was established to provide creative reconstruction of the Tohoku area that suffered from a huge earthquake and ensuing tsunami (the Great East Japan Earthquake, GEJE). TMM aims to establish two large-scale genome cohorts and an integrated biobank managing biospecimen and related information. It supports community medicine by establishing next-generation medical systems through a combination of the prospective genome cohort studies with a total of 150,000 participants and genomic medicine. The strategies for genome analyses in TMM are to develop an elaborate genome reference panel by means of high-fidelity Japanese whole-genome sequence, to design custom single nucleotide polymorphism (SNP) arrays based on the reference panel, and to obtain genotype data for all the TMM cohort participants subsequently. Disease-associated genomic information and omics data, including metabolomics and microbiome analysis, provide an essential platform for precision medicine and personalized healthcare (PHC). Ethical, legal, and social issues (ELSI) and education are important for implementing genomic medicine. The major considerations of ELSI regarding each participant of the cohort studies are the respect for the autonomy and the protection of privacies. Moreover, developing and provide human resources not only for the TMM project but also for the social implementation of precision medicine and PHC is required. We started a pilot study of the return of genomic results for familial hypercholesterolemia (FH) as a target disease. TMM aims to establish solid platforms that support precision medicine and PHC based on the genomic and omics information and environmental and lifestyle factors of the individuals, which is one of the most advanced medical care beyond the evidenced-based medicine in the near future.

  14. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective. International-journal Peer-reviewed

    Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    International journal of epidemiology　2019/08/25

    DOI： 10.1093/ije/dyz169 　

    ISSN： 0300-5771

  15. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. Peer-reviewed

    Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Fuji Nagami, Naoko Minegishi, Soichi Ogishima, Takako Takai-Igarashi, Inaho Danjoh, Taku Obara, Mami Ishikuro, Tomoko Kobayashi, Yayoi Aizawa, Rino Ishihara, Masayuki Yamamoto, Yoichi Suzuki

    BMC Medical Education　19　(1)　297　2019/08

    DOI： 10.1186/s12909-019-1725-5. 　

    ISSN： 1472-6920

  16. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. International-journal Peer-reviewed

    Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, Mika Sakurai-Yageta, Ikuko N Motoike, Yoko Kuroki, Sakae Saito, Kaname Kojima, Matsuyuki Shirota, Daisuke Saigusa, Akihito Otsuki, Junko Kawashima, Yumi Yamaguchi-Kabata, Shu Tadaka, Yuichi Aoki, Takahiro Mimori, Kazuki Kumada, Jin Inoue, Satoshi Makino, Miho Kuriki, Nobuo Fuse, Seizo Koshiba, Osamu Tanabe, Masao Nagasaki, Gen Tamiya, Ritsuko Shimizu, Takako Takai-Igarashi, Soichi Ogishima, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Akito Tsuboi, Hideyasu Kiyomoto, Tadashi Ishii, Hiroaki Tomita, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroshi Kawame, Hiroshi Tanaka, Yasuyuki Taki, Nobuo Yaegashi, Shigeo Kure, Fuji Nagami, Kenjiro Kosaki, Yoichi Sutoh, Tsuyoshi Hachiya, Atsushi Shimizu, Makoto Sasaki, Masayuki Yamamoto

    Journal of biochemistry　165　(2)　139-158　2019/02/01

    DOI： 10.1093/jb/mvy096 　

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    Personalized healthcare (PHC) based on an individual's genetic make-up is one of the most advanced, yet feasible, forms of medical care. The Tohoku Medical Megabank (TMM) Project aims to combine population genomics, medical genetics and prospective cohort studies to develop a critical infrastructure for the establishment of PHC. To date, a TMM CommCohort (adult general population) and a TMM BirThree Cohort (birth+three-generation families) have conducted recruitments and baseline surveys. Genome analyses as part of the TMM Project will aid in the development of a high-fidelity whole-genome Japanese reference panel, in designing custom single-nucleotide polymorphism (SNP) arrays specific to Japanese, and in estimation of the biological significance of genetic variations through linked investigations of the cohorts. Whole-genome sequencing from >3,500 unrelated Japanese and establishment of a Japanese reference genome sequence from long-read data have been done. We next aim to obtain genotype data for all TMM cohort participants (>150,000) using our custom SNP arrays. These data will help identify disease-associated genomic signatures in the Japanese population, while genomic data from TMM BirThree Cohort participants will be used to improve the reference genome panel. Follow-up of the cohort participants will allow us to test the genetic markers and, consequently, contribute to the realization of PHC.

  17. 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. International-journal Peer-reviewed

    Shu Tadaka, Fumiki Katsuoka, Masao Ueki, Kaname Kojima, Satoshi Makino, Sakae Saito, Akihito Otsuki, Chinatsu Gocho, Mika Sakurai-Yageta, Inaho Danjoh, Ikuko N Motoike, Yumi Yamaguchi-Kabata, Matsuyuki Shirota, Seizo Koshiba, Masao Nagasaki, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Atsushi Shimizu, Jun Yasuda, Nobuo Fuse, Gen Tamiya, Masayuki Yamamoto, Kengo Kinoshita

    Human genome variation　6　(28)　28-28　2019

    DOI： 10.1038/s41439-019-0059-5 　

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    The first step towards realizing personalized healthcare is to catalog the genetic variations in a population. Since the dissemination of individual-level genomic information is strictly controlled, it will be useful to construct population-level allele frequency panels with easy-to-use interfaces. In the Tohoku Medical Megabank Project, we sequenced nearly 4000 individuals from a Japanese population and constructed an allele frequency panel of 3552 individuals after removing related samples. The panel is called the 3.5KJPNv2. It was constructed by using a standard pipeline including the 1KGP and gnomAD algorithms to reduce technical biases and to allow comparisons to other populations. Our database is the first large-scale panel providing the frequencies of variants present on the X chromosome and on the mitochondria in the Japanese population. All the data are available on our original database at https://jmorp.megabank.tohoku.ac.jp.

  18. Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project Peer-reviewed

    Naoko Minegishi, Ichiko Nishijima, Takahiro Nobukuni, Hisaaki Kudo, Noriko Ishida, Takahiro Terakawa, Kazuki Kumada, Riu Yamashita, Fumiki Katsuoka, Soichi Ogishima, Kichiya Suzuki, Makoto Sasaki, Mamoru Satoh, Tohoku Medical Megabank Project Study Group, Masayuki Yamamoto

    The Tohoku Journal of Experimental Medicine　248　(1)　45-55　2019

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.248.45 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  19. Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project. International-journal Peer-reviewed

    Jun Yasuda, Fumiki Katsuoka, Inaho Danjoh, Yosuke Kawai, Kaname Kojima, Masao Nagasaki, Sakae Saito, Yumi Yamaguchi-Kabata, Shu Tadaka, Ikuko N Motoike, Kazuki Kumada, Mika Sakurai-Yageta, Osamu Tanabe, Nobuo Fuse, Gen Tamiya, Koichiro Higasa, Fumihiko Matsuda, Nobufumi Yasuda, Motoki Iwasaki, Makoto Sasaki, Atsushi Shimizu, Kengo Kinoshita, Masayuki Yamamoto

    BMC genomics　19　(1)　551-551　2018/07/24

    DOI： 10.1186/s12864-018-4942-0 　

    More details Close

    BACKGROUND: Genotype imputation from single-nucleotide polymorphism (SNP) genotype data using a haplotype reference panel consisting of thousands of unrelated individuals from populations of interest can help to identify strongly associated variants in genome-wide association studies. The Tohoku Medical Megabank (TMM) project was established to support the development of precision medicine, together with the whole-genome sequencing of 1070 human genomes from individuals in the Miyagi region (Northeast Japan) and the construction of the 1070 Japanese genome reference panel (1KJPN). Here, we investigated the performance of 1KJPN for genotype imputation of Japanese samples not included in the TMM project and compared it with other population reference panels. RESULTS: We found that the 1KJPN population was more similar to other Japanese populations, Nagahama (south-central Japan) and Aki (Shikoku Island), than to East Asian populations in the 1000 Genomes Project other than JPT, suggesting that the large-scale collection (more than 1000) of Japanese genomes from the Miyagi region covered many of the genetic variations of Japanese in mainland Japan. Moreover, 1KJPN outperformed the phase 3 reference panel of the 1000 Genomes Project (1KGPp3) for Japanese samples, and IKJPN showed similar imputation rates for the TMM and other Japanese samples for SNPs with minor allele frequencies (MAFs) higher than 1%. CONCLUSIONS: 1KJPN covered most of the variants found in the samples from areas of the Japanese mainland outside the Miyagi region, implying 1KJPN is representative of the Japanese population's genomes. 1KJPN and successive reference panels are useful genome reference panels for the mainland Japanese population. Importantly, the addition of whole genome sequences not included in the 1KJPN panel improved imputation efficiencies for SNPs with MAFs under 1% for samples from most regions of the Japanese archipelago.

  20. The Tohoku Medical Megabank Project: Design and Mission Peer-reviewed

    Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, Masayuki Yamamoto

    JOURNAL OF EPIDEMIOLOGY　26　(9)　493-511　2016/09

    DOI： 10.2188/jea.JE20150268 　

    ISSN： 0917-5040

  21. Erratum to: Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism. Peer-reviewed

    Mashimo Y, Sakurai-Yageta M, Watanabe M, Arima T, Morita Y, Inoue Y, Sato K, Nishimuta T, Suzuki S, Watanabe H, Hoshioka A, Tomiita M, Yamaide A, Kohno Y, Okamoto Y, Shimojo N, Hata A, Suzuki Y

    Inflammation　39　(3)　963　2016/06

    DOI： 10.1007/s10753-016-0334-2 　

    ISSN： 0360-3997

  22. Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism (vol 39, pg 949, 2016) Peer-reviewed

    Yoichi Mashimo, Mika Sakurai-Yageta, Misa Watanabe, Takayasu Arima, Yoshinori Morita, Yuzaburo Inoue, Kazuki Sato, Toshiyuki Nishimuta, Shuichi Suzuki, Hiroko Watanabe, Akira Hoshioka, Minako Tomiita, Akiko Yamaide, Yoichi Kohno, Yoshitaka Okamoto, Naoki Shimojo, Akira Hata, Yoichi Suzuki

    INFLAMMATION　39　(3)　963-963　2016/06

    DOI： 10.1007/s10753-016-0334-2 　

    ISSN： 0360-3997

    eISSN： 1573-2576

  23. Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells Peer-reviewed

    Hasaya Dokduang, Puangrat Yongvanit, Nisana Namwat, Chawalit Pairojkul, Sakkarn Sangkhamanon, Mika Sakurai Yageta, Yoshinori Murakami, Watcharin Loilome

    ONCOLOGY REPORTS　35　(4)　2065-2072　2016/04

    DOI： 10.3892/or.2016.4584 　

    ISSN： 1021-335X

    eISSN： 1791-2431

  24. Dynamic Regulation of a Cell Adhesion Protein Complex Including CADM1 by Combinatorial Analysis of FRAP with Exponential Curve-Fitting Peer-reviewed

    Mika Sakurai-Yageta, Tomoko Maruyama, Takashi Suzuki, Kazuhisa Ichikawa, Yoshinori Murakami

    PLOS ONE　10　(3)　e0116637　2015/03

    DOI： 10.1371/journal.pone.0116637 　

    ISSN： 1932-6203

  25. Genomic and transcriptional alterations of cholangiocarcinoma Peer-reviewed

    Takeshi Ito, Mika Sakurai-Yageta, Akiteru Goto, Chawalit Pairojkul, Puangrat Yongvanit, Yoshinori Murakami

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　21　(6)　380-387　2014/06

    DOI： 10.1002/jhbp.67 　

    ISSN： 1868-6974

    eISSN： 1868-6982

  26. Trans-Homophilic Interaction of CADM1 Activates PI3K by Forming a Complex with MAGuK-Family Proteins MPP3 and Dlg Peer-reviewed

    Shigefumi Murakami, Mika Sakurai-Yageta, Tomoko Maruyama, Yoshinori Murakami

    PLOS ONE　9　(2)　e110062　2014/02

    DOI： 10.1371/journal.pone.0082894 　

    ISSN： 1932-6203

  27. Involvement of miR-214 and miR-375 in malignant features of Non-small-cell lung cancer by down-regulating CADM1 Peer-reviewed

    Ishimura M, Sakurai-Yageta M, Maruyama T, Ando T, Fukayama M, Goto A, Murakami Y

    Journal of Cancer Therapy　3　(4A)　379-387　2012/09

    DOI： 10.4236/jct.2012.324050 　

  28. Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer Peer-reviewed

    Yuka Takahashi, Miwako Iwai, Taketo Kawai, Atsushi Arakawa, Takeshi Ito, Mika Sakurai-Yageta, Akihiko Ito, Akiteru Goto, Mitsue Saito, Fujio Kasumi, Yoshinori Murakami

    BREAST CANCER　19　(3)　242-252　2012/07

    DOI： 10.1007/s12282-011-0272-7 　

    ISSN： 1340-6868

  29. Expression of a splicing variant of the CADM1 specific to small cell lung cancer Peer-reviewed

    Shinji Kikuchi, Miwako Iwai, Mika Sakurai-Yageta, Yumi Tsuboi, Takeshi Ito, Tomoko Maruyama, Hitoshi Tsuda, Yae Kanai, Masataka Onizuka, Yukio Sato, Yoshinori Murakami

    CANCER SCIENCE　103　(6)　1051-1057　2012/06

    DOI： 10.1111/j.1349-7006.2012.02277.x 　

    ISSN： 1347-9032

  30. Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma Peer-reviewed

    Masayoshi Nagata, Mika Sakurai-Yageta, Daisuke Yamada, Akiteru Goto, Akihiko Ito, Hiroshi Fukuhara, Haruki Kume, Teppei Morikawa, Masashi Fukayama, Yukio Homma, Yoshinori Murakami

    INTERNATIONAL JOURNAL OF CANCER　130　(6)　1329-1337　2012/03

    DOI： 10.1002/ijc.26160 　

    ISSN： 0020-7136

  31. Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells Peer-reviewed

    Takeshi Ito, Yuko Williams-Nate, Miwako Iwai, Yumi Tsuboi, Man Hagiyama, Akihiko Ito, Mika Sakurai-Yageta, Yoshinori Murakami

    GENES TO CELLS　16　(7)　791-802　2011/07

    DOI： 10.1111/j.1365-2443.2011.01525.x 　

    ISSN： 1356-9597

  32. Tumor suppressor CADM1 is involved in epithelial cell structure Peer-reviewed

    Mika Sakurai-Yageta, Mari Masuda, Yumi Tsuboi, Akihiko Ito, Yoshinori Murakami

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　390　(3)　977-982　2009/12

    DOI： 10.1016/j.bbrc.2009.10.088 　

    ISSN： 0006-291X

  33. The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA Peer-reviewed

    Mika Sakurai-Yageta, Chiara Recchi, Gaelle Le Dez, Jean-Baptiste Sibarita, Laurent Daviet, Jacques Camonis, Crislyn D'Souza-Schorey, Philippe Chavrier

    JOURNAL OF CELL BIOLOGY　181　(6)　985-998　2008/06

    DOI： 10.1083/jcb.200709076 　

    ISSN： 0021-9525

  34. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4 Peer-reviewed

    YN Williams, M Masuda, M Sakurai-Yageta, T Maruyama, M Shibuya, Y Murakami

    ONCOGENE　25　(10)　1446-1453　2006/03

    DOI： 10.1038/sj.onc.1209192 　

    ISSN： 0950-9232

  35. Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma Peer-reviewed

    D Yamada, S Kikuchi, YN Williams, M Sakurai-Yageta, M Masuda, T Maruyama, K Tomita, DH Gutmann, T Kakizoe, T Kitamura, Y Kanai, Y Murakami

    INTERNATIONAL JOURNAL OF CANCER　118　(4)　916-923　2006/02

    DOI： 10.1002/ijc.21450 　

    ISSN： 0020-7136

  36. Tumor suppressor in lung cancer (TSLC)1 suppresses epithelial cell scattering and tubulogenesis Peer-reviewed

    M Masuda, S Kikuchi, T Maruyama, M Sakurai-Yageta, YN Williams, HP Ghosh, Y Murakami

    JOURNAL OF BIOLOGICAL CHEMISTRY　280　(51)　42164-42171　2005/12

    DOI： 10.1074/jbc.M507136200 　

    ISSN： 0021-9258

  37. Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer Peer-reviewed

    S Kikuchi, D Yamada, T Fukami, M Masuda, M Sakurai-Yageta, YN Williams, T Maruyama, H Asamura, Y Matsuno, M Onizuka, Y Murakami

    CLINICAL CANCER RESEARCH　11　(8)　2954-2961　2005/04

    DOI： 10.1158/1078-0432.CCR-04-2206 　 10.1158/1078-0432.ccr-04-2206 　

    ISSN： 1078-0432

  38. Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary, nonpolyposis, colorectal cancer and retinoblastoma by an RNA difference plot Peer-reviewed

    Yoshinori Murakami, Kana Isogai, Hiroyuki Tomita, Mika Sakurai-Yageta, Tomoko Maruyama, Akio Hidaka, Kiyoshi Nose, Kokichi Sugano, Akihiro Kaneko

    Journal of Human Genetics　49　(11)　635-641　2004/11

    DOI： 10.1007/s10038-004-0201-0 　

    ISSN： 1434-5161

  39. Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary, nonpolyposis, colorectal cancer and retinoblastoma by an RNA difference plot Peer-reviewed

    Y Murakami, K Isogai, H Tomita, M Sakurai-Yageta, T Maruyama, A Hidaka, K Nose, K Sugano, A Kaneko

    JOURNAL OF HUMAN GENETICS　49　(11)　635-641　2004/11

    DOI： 10.1007/s10038-004-0201-0 　

    ISSN： 1435-232X

  40. Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2) Peer-reviewed

    T Fukami, H Satoh, YN Williams, M Masuda, H Fukuhara, T Maruyama, M Yageta, M Kuramochi, S Takamoto, Y Murakami

    GENE　323　11-18　2003/12

    DOI： 10.1016/j.gene.2003.09.018 　

    ISSN： 0378-1119

  41. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg Peer-reviewed

    H Fukuhara, M Masvuda, M Yageta, T Fukami, M Kuramochi, T Maruyama, T Kitamura, Y Murakami

    ONCOGENE　22　(40)　6160-6165　2003/09

    DOI： 10.1038/sj.onc.1206744 　

    ISSN： 0950-9232

  42. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer Peer-reviewed

    M Yageta, M Kuramochi, M Masuda, T Fukami, H Fukuhara, T Maruyama, M Shibuya, Y Murakami

    CANCER RESEARCH　62　(18)　5129-5133　2002/09

    ISSN： 0008-5472

  43. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion Peer-reviewed

    M Masuda, M Yageta, H Fukuhara, M Kuramochi, T Maruyama, A Nomoto, Y Murakami

    JOURNAL OF BIOLOGICAL CHEMISTRY　277　(34)　31014-31019　2002/08

    DOI： 10.1074/jbc.M203620200 　

    ISSN： 0021-9258

  44. Cdc6 requires anchorage for its expression Peer-reviewed

    S Jinno, M Yageta, A Nagata, H Okayama

    ONCOGENE　21　(11)　1777-1784　2002/03

    DOI： 10.1038/sj/onc/1205249 　

    ISSN： 0950-9232

  45. Oncogenic cell cycle start control Peer-reviewed

    S Jinno, J Lin, M Yageta, H Okayama

    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS　477　(1-2)　23-29　2001/06

    DOI： 10.1016/S0027-5107(01)00092-6 　 10.1016/s0027-5107(01)00092-6 　

    ISSN： 0027-5107

  46. The adenovirus E1A domains required for induction of DNA rereplication in G(2)/M arrested cells coincide with those required for apoptosis Peer-reviewed

    M Yageta, H Tsunoda, T Yamanaka, T Nakajima, Y Tomooka, N Tsuchida, K Oda

    ONCOGENE　18　(34)　4767-4776　1999/08

    DOI： 10.1038/sj.onc.1203063 　

    ISSN： 0950-9232

  47. Effects of wild-type and mutated p53 and Id proteins on the induction of apoptosis by adenovirus E1A, c-Myc, Bax, and Nip3 in p53 null mouse cerebellum cells Peer-reviewed

    H Tsunoda, T Terasawa, M Yageta, T Nakajima, Y Tomooka, N Tsuchida, K Oda

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　255　(3)　722-730　1999/02

    DOI： 10.1006/bbrc.1999.0143 　

    ISSN： 0006-291X

  48. Suppression of adenovirus E1A-induced apoptosis by mutated p53 is overcome by coexpression with Id proteins Peer-reviewed

    T Nakajima, M Yageta, K Shiotsu, K Morita, M Suzuki, Y Tomooka, K Oda

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　95　(18)　10590-10595　1998/09

    DOI： 10.1073/pnas.95.18.10590 　

    ISSN： 0027-8424

Show all ︎Show first 5

Misc. 26

  1. 東北メディカル・メガバンク計画における遺伝情報返却の課題

    濱中洋平, 濱中洋平, 大根田絹子, 布施昇男, 川目裕, 川目裕, 長神風二, 鈴木吉也, 鈴木洋一, 鈴木洋一, 佐藤政文, 平塚真弘, 櫻井美佳, 宇留野晃, 山口由美, 平良摩紀子, 山本雅之, 濱中洋平, 濱中洋平

    日本人類遺伝学会大会プログラム・抄録集　65th (CD-ROM)　2020

  2. ゲノムコホート調査参加者に対するゲノム薬理学(PGx)遺伝情報の返却(回付)-PGxの知識・理解に関する調査票解析

    大根田絹子, 布施昇男, 川目裕, 川目裕, 長神風二, 鈴木吉也, 鈴木洋一, 鈴木洋一, 佐藤政文, 櫻井美佳, 宇留野晃, 濱中洋平, 平良摩紀子, 平塚真弘, 山本雅之, 山本雅之

    日本人類遺伝学会大会プログラム・抄録集　65th (CD-ROM)　2020

  3. AMEDにおけるゲノム医療実現に向けた新たなアプローチ -データシェアリングポリシーの策定とその舞台裏-

    三成 寿作, 加藤 治, 櫻井 美佳, 齋藤 あき

    遺伝子医学MOOK 33号　2018/04

  4. Tohoku Medical Megabank Project and the prospects of genomic medicine

    7　(2)　115-120　2018/02

    ISSN： 2188-9147

  5. 細胞接着分子CADM1複合体の動態解明―指数関数あてはめを用いたFRAPデータの解析

    伊東 剛, 櫻井(八下田, 美佳, 村上善則

    35　(5)　2017/03

  6. 「遺伝の仕組み」と「多様性」を学ぶための小児を対象とした遺伝教育ツール開発の取り組み

    小林朋子, 小林朋子, 菅原美智子, 石原利乃, 本郷一夫, 相澤弥生, 山口由美, 齋藤さかえ, 田中由佳里, 栗木美穂, 長神風二, 安田純, 櫻井美佳, 栗山進一, 川目裕, 鈴木吉也, 山本雅之, 鈴木洋一, 鈴木洋一

    日本人類遺伝学会大会プログラム・抄録集　62nd　324　2017

  7. 東北メディカル・メガバンク計画とゲノム研究の展望

    櫻井 美佳, 清元 秀泰

    腎臓内科・泌尿器科　5　(1)　87-93　2017/01

    ISSN： 2188-9147

  8. 肺腺がん細胞の実験的転移系を用いた転移関連分子の同定と機能解析

    熊谷 友紀, 伊東 剛, 永田 政義, 川合 剛人, 丸山 智子, 櫻井 美佳, 八下田, 後藤 明輝, 松原 大祐, 村上 善則

    日本癌学会総会記事　74回　J-1269　2015/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  9. Analysis of the role of CADM1 in suppression of lung cancer using Cadm1-deficient mice

    Takeshi Ito, Masayoshi Nagata, Taketo Kawai, Mika Sakurai-Yageta, Akihiko Ito, Akiteru Goto, Daisuke Matsubara, Yoshinori Murakami

    CANCER RESEARCH　75　2015/08

    DOI： 10.1158/1538-7445.AM2015-2302 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  10. Trans-Homophilic Interaction of CADM1 Activates PI3K by Forming a Complex with MAGuK-Family Proteins MPP3 and Dlg (vol 9, e82894, 2014)

    S. Murakami, M. Sakurai-Yageta, T. Maruyama, Y. Murakami

    PLOS ONE　9　(9)　2014/09

    DOI： 10.1371/journal.pone.0110062 　

    ISSN： 1932-6203

  11. 遺伝子欠損マウスを用いたCADM1の肺腫瘍抑制における役割の解明(Analysis of the role of CADM1 in suppression of lung cancer using Cadm1-deficient mice)

    伊東 剛, 永田 政義, 川合 剛人, 丸山 智子, 櫻井 美佳, 八下田, 伊藤 彰彦, 後藤 明輝, 松原 大祐, 村上 善則

    日本癌学会総会記事　73回　P-2021　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  12. 肺腺がん細胞株の実験的肺転移における遺伝子発現変動を指標として抽出される転移関連因子の探索(Screening of metastasis-related genes by microarray analysis of lung cancer cells using experimental lung metastasis)

    熊谷 友紀, 伊東 剛, 永田 政義, 川合 剛人, 丸山 智子, 櫻井 美佳, 八下田, 後藤 明輝, 松原 大祐, 村上 善則

    日本癌学会総会記事　73回　P-3133　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  13. EXPRESSION OF A SPLICING VARIANT OF THE CADM1 SPECIFIC TO SMALL CELL LUNG CANCER

    Shinji Kikuchi, Miwako Iwai, Mika Sakurai-Yageta, Yumi Tsuboi, Takeshi Ito, Tomoko Maruyama, Hitoshi Tsuda, Yae Kanai, Yukinobu Goto, Mitsuaki Sakai, Masataka Onizuka, Yukio Sato, Yoshinori Murakami

    JOURNAL OF THORACIC ONCOLOGY　8　S754-S754　2013/11

    ISSN： 1556-0864

    eISSN： 1556-1380

  14. 遺伝子欠損マウスを用いたCADM1の肺腫瘍抑制における役割の解明(Analysis of the role of CADM1 in suppression of lung cancer development using Cadm1-deficient mice)

    伊東 剛, 永田 政義, 川合 剛人, 丸山 智子, 櫻井 美佳, 八下田, 伊藤 彰彦, 後藤 明輝, 松原 大祐, 村上 善則

    日本癌学会総会記事　71回　246-246　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  15. 肺腺がんのEGFR-TK阻害剤に対する耐性獲得における細胞接着分子CADM1の役割(Possible involvement of a cell adhesion molecule, CADM1 in acquired resistance of lung adenocarcinoma to EGFR-TKIs)

    桑野 秀規, 岩井 美和子, 川合 剛人, 伊東 剛, 桜井 美佳, 八下田, 後藤 明輝, 小泉 史明, 中島 淳, 田村 研治, 村上 善則

    日本癌学会総会記事　71回　442-442　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  16. がん研究への病理学の新しい関わり方 分子病理学的解析が示す細胞接着分子CADM1のヒト肺癌における抑制、促進両面の役割(Concurrent integration of pathology and cancer research Dual roles of a cell adhesion molecule, CADM1, in lung oncogenesis based on the molecular pathological analyses)

    村上 善則, 桜井 美佳, 伊東 剛, 桑野 秀規, 松原 大祐, 後藤 明輝

    日本癌学会総会記事　71回　450-450　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  17. 肺腺がん細胞株の実験的肺転移における遺伝子発現変動を指標として抽出される転移関連因子の探索(Screening of metastasis-related genes by microarray analysis of lung cancer cells using experimental lung metastasis)

    熊谷 友紀, 伊東 剛, 永田 政義, 川合 剛人, 丸山 智子, 櫻井 美佳, 八下田, 後藤 明輝, 村上 善則

    日本癌学会総会記事　71回　487-487　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  18. 肝吸虫関連および非関連肝内胆管癌におけるCADM1の発現 日本及びタイ症例の比較研究(Loss of CADM1 expression in cholangiocarcinoma related and unrelated to liver fluke infection)

    後藤 明輝, 櫻井 美佳, 八下田, Pairojkul Chawalit, Yongvanit Puangrat, 柴原 純二, 深山 正久, 村上 善則

    日本癌学会総会記事　70回　303-303　2011/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  19. 乳がんの進展、再発に関わる細胞接着分子CADM1、並びに新規分子標的の解析(Identification of molecular targets involved in the progression and recurrence of breast cancer)

    村上 善則, 高橋 由佳, 岩井 美和子, 荒川 敦, 伊東 剛, 櫻井 美佳, 八下田, 伊藤 彰彦, 後藤 明輝, 伊東 紀子, 江見 充, 齋藤 光江, 霞 富士雄

    日本癌学会総会記事　70回　215-215　2011/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  20. miR-375およびmiR-214/199aによるCADM1の発現抑制とそのがん化への関与(Suppression of CADM1 expression by miR-375 and miR-214/199a and its role in tumorigenesis)

    石村 恵, 櫻井 美佳, 八下田, 後藤 明輝, 村上 善則

    日本癌学会総会記事　70回　269-269　2011/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  21. Spontaneous development of lung adenocarcinoma in the CADM1 gene-deficient mice. Peer-reviewed

    Nagata M, Sakurai-Yageta M, Yamada D, Kawai T, Tsuboi Y, Ito T, Ito A, Yoshida M, Murakami Y

    BMC Proceedings　2010/09

    DOI： 10.1186/1753-6561-4-s2-o18 　

  22. DISRUPTION OF CDM4-4.1B CASCADE OF CELL ADHESION IN RENAL CLEAR CELL CARCINOMA

    Masayoshi Nagata, Mika Sakurai-Yageta, Daisuke Yamada, Akihiko Ito, Haruki Kume, Teppei Morikawa, Yoshinori Murakami, Yukio Homma

    JOURNAL OF UROLOGY　183　(4)　E141-E142　2010/04

    DOI： 10.1016/j.juro.2010.02.424 　

    ISSN： 0022-5347

    eISSN： 1527-3792

  23. Spontaeous development of lung adenocarcinoma in mice lacking the tumor suppressor gene, CADM1/TSLC1

    Yoshinori Murakami, Masayoshi Nagata, Daisuke Yamada, Mika Sakurai-Yageta, Miwako Iwai, Takashi Obana, Taketo Kawai, Mari Masuda, Yumi Tsuboi, Hiromi Ichihara, Tomoko Maruyama, Akihiko Ito

    CANCER RESEARCH　69　2009/05

    ISSN： 0008-5472

    eISSN： 1538-7445

  24. Promoter methylation of the DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer

    S Kikuchi, D Yamada, M Masuda, M Sakurai-Yageta, YN Williams, T Maruyama, H Asamura, Y Matsuno, M Onizuka, Y Murakami

    LUNG CANCER　49　S130-S130　2005/07

    ISSN： 0169-5002

  25. TSLC1 affects HGF-induced cell motility of epithelial cells

    Mari Masuda, Mika Sakurai-Yageta, Yuko N. Williams, Tomoko Maruyama, O. Yoshinori Murakami

    CELL STRUCTURE AND FUNCTION　29　28-28　2004/05

    ISSN： 0386-7196

    eISSN： 1347-3700

  26. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg (vol 22, pg 6160, 2003)

    H Fukuhara, M Masuda, M Yageta, T Fukami, M Kuramochi, T Maruyama, T Kitamura, Y Murakami

    ONCOGENE　23　(2)　629-629　2004/01

    DOI： 10.1038/sj.onc.1207365 　

    ISSN： 0950-9232

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Research Projects 10

  1. The role of biotin transport in airway inflammation

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  2. A molecular-epidemiological study on risk factors of gallbladder cancer

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Aichi Medical University

    2021/04/01 - 2024/03/31

  3. Genetic and molecular epidemiology study of GWAS-identified pancreatic cancer-associated GP2 gene

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Aichi Medical University

    2021/04/01 - 2024/03/31

  4. Interdisciplinary fusion research for precision medicine in heart failure patients with preserved ejection fraction

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Hokkaido University

    2020/04/01 - 2024/03/31

  5. ビオチン代謝によるアレルギー性気道炎症の制御メカニズムの解明 Competitive

    櫻井 美佳

    Offer Organization: 文部科学省

    System: 科研費補助金 基盤研究(C)

    2016/04 - 2019/03

  6. Analysis of cell-context dependent features of adhesion molecules for cancer diagnosis

    MURAKAMI Yoshinori

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: The University of Tokyo

    2013/04/01 - 2016/03/31

    More details Close

    MET is a receptor of HGF growth factor and is activated by gene amplification and/or overexpression in various cancer to promote cell growth and epithelial to mesenchymal transition. We have demonstrated that a cell adhesion molecule, CADM1, forms a complex with MET on the raft of the cell membrane and suppresses the MET signaling. CADM1 is known to be often inactivated in various cancer cells in their advanced stages. CADM1 could provide a molecular target to suppress oncogenic signaling of cancer cells to malignant growth.

  7. 生体イメージングを用いた細胞接着分子CADM1のがん化における役割の解析 Competitive

    櫻井 美佳

    Offer Organization: 文部科学省

    System: 科研費補助金 若手研究(B)

    2012/04 - 2015/03

  8. 細胞接着分子群の解析に基づく、がんの個性診断法の開発 Competitive

    村上 善則

    Offer Organization: 文部科学省

    System: 科研費補助金 基盤研究(B)

    2010/04 - 2013/03

  9. Ig様接着分子CADM1による細胞間接着と浸潤における動態と下流分子経路の解明 Competitive

    櫻井 美佳

    Offer Organization: 文部科学省

    System: 科研費補助金 若手研究(B)

    2009/04 - 2012/03

  10. がん関連遺伝子の構造、発現、機能解析によるがんの分子診断と病態の解明 Competitive

    村上 善則

    Offer Organization: 文部科学省

    System: 科研費補助金 特定領域研究

    2005/04 - 2010/03

Show all Show first 5