-
Synthesis of 2-Phosphorus-Substituted Indoles via Ring Expansion of Benzocyclobutenone Oxime Sulfonates
Peer-reviewed
Yusuke Kanno, Yumi Yamashita, Akira Sugiyama, Tatsuhiko Kodama, Juri Sakata, Hidetoshi Tokuyama
Organic Letters 2025/05/29
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/acs.orglett.5c01778
ISSN：
1523-7060
eISSN：
1523-7052
-
Semisynthetic Studies Establish a Role for Conjugate Halide Exchange in the Formation of Chlorinated Pyrroloiminoquinones and Related Alkaloids
Peer-reviewed
Samuele Sala, Masashi Shimomura, Louisa Tham, Juri Sakata, Alexandre N. Sobolev, Stephen A. Moggach, Jane Fromont, Oliver Gomez, Matthew J. Piggott, Hidetoshi Tokuyama, Scott G. Stewart, Gavin R. Flematti
Journal of Natural Products 2024/09/30
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/acs.jnatprod.4c00549
ISSN：
0163-3864
eISSN：
1520-6025
-
Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin
Peer-reviewed
Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko, Takeshi Kawamura, Mai Miura, Masazumi Ishii, Tsuyoshi Osawa, Toshiya Tanaka, Shumpei Ishikawa, Masanobu Tsukagoshi, Michael Chansler, Tatsuhiko Kodama, Motomu Kanai, Hidetoshi Tokuyama, Kenzo Yamatsugu
Protein Expression and Purification 106375-106375 2023/10/04
Publisher:
Elsevier BV
DOI：
10.1016/j.pep.2023.106375
ISSN：
1046-5928
-
Unified Divergent Total Synthesis of Discorhabdin B, H, K, and Aleutianamine via the Late-Stage Oxidative N,S-Acetal Formation
Peer-reviewed
Masashi Shimomura, Kohta Ide, Juri Sakata, Hidetoshi Tokuyama
Journal of the American Chemical Society 145 (33) 18233-18239 2023/08/23
DOI：
10.1021/jacs.3c06578
ISSN：
0002-7863 1520-5126
-
Concise Total Synthesis of (+)-Pleiocarpamine and Convergent Total Syntheses of (+)-Voacalgine A and (+)-Bipleiophylline via an Aerobic Oxidative Coupling
Peer-reviewed
Kosuke Okada, Ken-ichi Ojima, Hirofumi Ueda, Hidetoshi Tokuyama
Journal of the American Chemical Society 145 (30) 16337-16343 2023/07/24
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/jacs.3c05811
ISSN：
0002-7863
eISSN：
1520-5126
-
Synthetic Studies on Cimiciduphytine
Peer-reviewed
Ken-ichi Ojima, Hirofumi Ueda, Hidetoshi Tokuyama
Bulletin of the Chemical Society of Japan 96 (5) 484-495 2023/05/15
DOI：
10.1246/bcsj.20230054
ISSN：
0009-2673 1348-0634
-
Iron‐Catalyzed Biomimetic Dimerization of Tryptophan‐Containing Peptides
Peer-reviewed
Hirofumi Ueda, Soichiro Sato, Kenta Noda, Hiroyuki Hakamata, Eunsang Kwon, Nagao Kobayashi, Hidetoshi Tokuyama
Angewandte Chemie International Edition 62 (22) e202302404 2023/03/24
Publisher:
Wiley
DOI：
10.1002/anie.202302404
ISSN：
1433-7851
eISSN：
1521-3773
-
Efficient and Scalable Asymmetric Total Synthesis of (−)-Emetine with Pharmaceutical Grade Quality; First Multigram Scale Synthesis
Peer-reviewed
Masatoshi Yamada, Kazuki Azuma, Iori Takizawa, Yuki Ejima, Mitsuhisa Yamano, Kimio Satoh, Takayuki Doi, Hirofumi Ueda, Hidetoshi Tokuyama
Organic Process Research & Development 27 (2) 343-357 2023/01/24
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/acs.oprd.2c00355
ISSN：
1083-6160
eISSN：
1520-586X
-
Catalytic enantioselective 5-endo-bromocycloetherification of unactivated cyclic alkenes
Peer-reviewed
Haoran Xiong, Kei Yoshida, Kosuke Okada, Hirofumi Ueda, Hidetoshi Tokuyama
Tetrahedron Letters 101 153906-153906 2022/07
Publisher:
Elsevier {BV}
DOI：
10.1016/j.tetlet.2022.153906
ISSN：
0040-4039
-
Total synthesis of (±)-vinoxine: construction of the bridged pyrido[1,2-a]indole skeleton via Tf2O-mediated Bischler–Napieralski reaction and stereoselective radical cyclization
Invited
Peer-reviewed
Kosuke Okada, Hirofumi Ueda, Hidetoshi Tokuyama
Organic & Biomolecular Chemistry 20 (30) 5943-5947 2022/03/03
Publisher:
Royal Society of Chemistry ({RSC})
DOI：
10.1039/D2OB00274D
ISSN：
1477-0520 1477-0539
eISSN：
1477-0539
-
Construction of Tetrahydroquinolines with Spirocyclic Structures at the 4-Position
Peer-reviewed
Hidetoshi Tokuyama, Yuko Wakahara, Takahiro Noro, Juri Sakata, Hirofumi Ueda
HETEROCYCLES 105 (1) 438-438 2022/03
Publisher:
The Japan Institute of Heterocyclic Chemistry
DOI：
10.3987/com-22-s(r)16
ISSN：
0385-5414
-
Photoredox-catalyzed intramolecular cyclopropanation of alkenes with α-bromo-β-keto esters
Peer-reviewed
Kohta Ide, Miyu Furuta, Hidetoshi Tokuyama
Organic & Biomolecular Chemistry 19 (42) 9172-9176 2021/10/09
Publisher:
Royal Society of Chemistry ({RSC})
DOI：
10.1039/D1OB01733K
ISSN：
1477-0520 1477-0539
eISSN：
1477-0539
-
Synthetic studies on discorhabdin V: Construction of the A–F hexacyclic framework
Peer-reviewed
Takahiro Noro, Juri Sakata, Hidetoshi Tokuyama
Tetrahedron Letters 81 153333-153333 2021/09
Publisher:
Elsevier {BV}
DOI：
10.1016/j.tetlet.2021.153333
ISSN：
0040-4039
-
Synthesis of leuconoxine, leuconodine B, and rhazinilam by transformation of melodinine E via 6-hydro-21-dehydroxyleuconolam
Peer-reviewed
Atsushi Umehara, Hirofumi Ueda, Hidetoshi Tokuyama
Tetrahedron 79 131809-131809 2021/01
Publisher:
Elsevier BV
DOI：
10.1016/j.tet.2020.131809
ISSN：
0040-4020
-
Synthesis of substituted anilines via a gold-catalyzed three-component reaction
Invited
Peer-reviewed
Hirofumi Ueda, Ryota Yamamoto, Minami Yamaguchi, Hidetoshi Tokuyama
Organic & Biomolecular Chemistry 19 (4) 765-769 2021
Publisher:
Royal Society of Chemistry ({RSC})
DOI：
10.1039/D0OB02018D
ISSN：
1477-0520 1477-0539
eISSN：
1477-0539
-
Aerobic Dehydrogenation of N‐Heterocycles with Grubbs Catalyst: Its Application to Assisted‐Tandem Catalysis to Construct N‐Containing Fused Heteroarenes
Peer-reviewed
Daichi Kawauchi, Kenta Noda, Yoshiyuki Komatsu, Kei Yoshida, Hirofumi Ueda, Hidetoshi Tokuyama
Chemistry – A European Journal 26 (68) 15793-15798 2020/12/04
Publisher:
Wiley
DOI：
10.1002/chem.202001961
ISSN：
0947-6539 1521-3765
eISSN：
1521-3765
-
A Concise Enantioselective Total Synthesis of (−)‐Deoxoapodine
Peer-reviewed
Kei Yoshida, Kosuke Okada, Hirofumi Ueda, Hidetoshi Tokuyama
Angewandte Chemie International Edition 59 (51) 23089-23093 2020/10/15
Publisher:
Wiley
DOI：
10.1002/anie.202010759
ISSN：
1433-7851
eISSN：
1521-3773
-
Total syntheses of (–)-emestrin H and (–)-asteroxepin
Peer-reviewed
Kanato Umeki, Yusuke Ueda, Juri Sakata, Hidetoshi Tokuyama
Tetrahedron 76 (48) 131630-131630 2020/10
Publisher:
Elsevier BV
DOI：
10.1016/j.tet.2020.131630
ISSN：
0040-4020
-
Cyclic Sulfamidite as Simultaneous Protecting Group for Amino Alcohols: Development of a Mild Deprotection Protocol Using Thiophenol
Peer-reviewed
Juri Sakata, Kazunari Akita, Manabu Sato, Masashi Shimomura, Hidetoshi Tokuyama
Chemical and Pharmaceutical Bulletin 68 (10) 996-1000 2020/10/01
Publisher:
Pharmaceutical Society of Japan
DOI：
10.1248/cpb.c20-00531
ISSN：
0009-2363 1347-5223
-
Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst
Peer-reviewed
Tatsuki Utsumi, Kenta Noda, Daichi Kawauchi, Hirofumi Ueda, Hidetoshi Tokuyama
Advanced Synthesis & Catalysis 362 3583-3588 2020/07/14
Publisher:
Wiley
DOI：
10.1002/adsc.202000663
ISSN：
1615-4150
eISSN：
1615-4169
-
Divergent Total Syntheses of Isobatzellines A/B and Batzelline A
Peer-reviewed
Yumi Yamashita, Louna Poignant, Juri Sakata, Hidetoshi Tokuyama
Organic Letters 22 6239-6243 2020/07/05
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/acs.orglett.0c01894
ISSN：
1523-7060
eISSN：
1523-7052
-
Total Synthesis of (−)-Lepadiformine A via Radical Translocation–Cyclization Reaction
Peer-reviewed
Masashi Shimomura, Manabu Sato, Hiroki Azuma, Juri Sakata, Hidetoshi Tokuyama
Organic Letters 22 (9) 3313-3317 2020/05/01
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/acs.orglett.0c00474
ISSN：
1523-7060
eISSN：
1523-7052
-
Identification of Emetine as a Therapeutic Agent for Pulmonary Arterial Hypertension: Novel Effects of an Old Drug.
International-journal
Peer-reviewed
Mohammad Abdul Hai Siddique, Kimio Satoh, Ryo Kurosawa, Nobuhiro Kikuchi, Md Elias-Al-Mamun, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Satoshi Miyata, Hirofumi Ueda, Hidetoshi Tokuyama, Hiroaki Shimokawa
Arteriosclerosis, thrombosis, and vascular biology 39 (11) 2367-2385 2019/11
DOI：
10.1161/ATVBAHA.119.313309
-
Fluorescent Labeling Method Re-Evaluates the Intriguing Thermoresponsive Behavior of Poly(acrylamide-co-acrylonitrile)s with Upper Critical Solution Temperatures
Peer-reviewed
Chie Otsuka, Yuko Wakahara, Kohki Okabe, Juri Sakata, Masaki Okuyama, Akinobu Hayashi, Hidetoshi Tokuyama, Seiichi Uchiyama
Macromolecules 52 (20) 7646-7660 2019/10
DOI：
10.1021/acs.macromol.9b00880
ISSN：
0024-9297
eISSN：
1520-5835
-
Total Synthesis of (+)-CC-1065 Utilizing Ring Expansion Reaction of Benzocyclobutenone Oxime Sulfonate
Peer-reviewed
Taku Imaizumi, Yumi Yamashita, Yuki Nakazawa, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama
Organic Letters 21 (16) 6185-6189 2019/08/16
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/acs.orglett.9b01690
ISSN：
1523-7060
eISSN：
1523-7052
-
Synthesis of Propargylic Ethers by Gold-Mediated Reaction of Terminal Alkynes with Acetals
Peer-reviewed
Miyu Furuta, Kyoko Sugiyama, Minami Yamaguchi, Hirofumi Ueda, Hidetoshi Tokuyama
Chemical and Pharmaceutical Bulletin 67 (8) 872-876 2019/08/01
Publisher:
Pharmaceutical Society of Japan
DOI：
10.1248/cpb.c19-00322
ISSN：
0009-2363
eISSN：
1347-5223
-
Construction of Indole Structure on Pyrroloindolines via AgNTf2-Mediated Amination/Cyclization Cascade: Application to Total Synthesis of (+)-Pestalazine B
Hiroyuki Hakamata, Hirofumi Ueda, Hidetoshi Tokuyama
Organic Letters 21 (11) 2019/06/07
DOI：
10.1021/acs.orglett.9b01399
-
Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision
Peer-reviewed
Yuzo Mogi, Kazato Inanaga, Hidetoshi Tokuyama, Masataka Ihara, Yousuke Yamaoka, Ken-ichi Yamada, Kiyosei Takasu
Organic Letters 21 (11) 3954-3958 2019/06/07
Publisher:
American Chemical Society (ACS)
DOI：
10.1021/acs.orglett.9b01089
ISSN：
1523-7060
eISSN：
1523-7052
-
Double Functionalization of Styrenes by Cu‐Mediated Assisted Tandem Catalysis
Peer-reviewed
Daichi Kawauchi, Hirofumi Ueda, Hidetoshi Tokuyama
European Journal of Organic Chemistry 2019 (10) 2056-2060 2019/03/14
Publisher:
Wiley
DOI：
10.1002/ejoc.201900088
ISSN：
1434-193X
-
Construction of Indole Structure on Pyrroloindolines via AgNTf<inf>2</inf>-Mediated Amination/Cyclization Cascade: Application to Total Synthesis of (+)-Pestalazine B
Hakamata, H., Ueda, H., Tokuyama, H.
Organic Letters 21 (11) 2019
DOI：
10.1021/acs.orglett.9b01399
-
Synthetic studies on plakinidines
Peer-reviewed
Satoh, T., Adachi, T., Okano, K., Sakata, J., Tokuyama, H.
Heterocycles 99 (1) 310-323 2019
DOI：
10.3987/COM-18-S(F)26
-
Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell.
International-journal
Peer-reviewed
Norihiko Sugisawa, Shinobu Ohnuma, Hirofumi Ueda, Megumi Murakami, Kyoko Sugiyama, Kosuke Ohsawa, Kuniyuki Kano, Hidetoshi Tokuyama, Takayuki Doi, Junken Aoki, Masaharu Ishida, Katsuyoshi Kudoh, Takeshi Naitoh, Suresh V Ambudkar, Michiaki Unno
Molecular pharmaceutics 15 (9) 4021-4030 2018/09/04
DOI：
10.1021/acs.molpharmaceut.8b00457
-
A Cell-Targeted Non-Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium-Containing Cationic Radical Initiator
Peer-reviewed
Seiichi Uchiyama, Toshikazu Tsuji, Kyoko Kawamoto, Kentaro Okano, Eiko Fukatsu, Takahiro Noro, Kumiko Ikado, Sayuri Yamada, Yuka Shibata, Teruyuki Hayashi, Noriko Inada, Masaru Kato, Hideki Koizumi, Hidetoshi Tokuyama
Angewandte Chemie - International Edition 57 (19) 5413-5417 2018/05/04
Publisher:
Wiley-VCH Verlag
DOI：
10.1002/anie.201801495
ISSN：
1521-3773 1433-7851
-
Synthesis of 9,10-Diarylanthracenes via Mg(TMP) 2 ·2LiCl-Mediated Benzyne Generation/[4+2] Cycloaddition and Deoxygenation of 9,10-Epoxyanthracene Intermediates
Peer-reviewed
Naoya Miyamoto, Yuki Nakazawa, Takanori Nakamura, Kentaro Okano, Sota Sato, Zhe Sun, Hiroyuki Isobe, Hidetoshi Tokuyama
Synlett 29 (4) 513-518 2018/03/01
Publisher:
Georg Thieme Verlag
DOI：
10.1055/s-0036-1591510
ISSN：
1437-2096 0936-5214
-
Cordybislactone, a stereoisomer of the 14-membered bislactone clonostachydiol, from the hopper pathogenic fungus Cordyceps sp. BCC 49294: Revision of the absolute configuration of clonostachydiol
Peer-reviewed
Ken-Ichi Ojima, Arunrat Yangchum, Pattiyaa Laksanacharoen, Kanoksri Tasanathai, Donnaya Thanakitpipattana, Hidetoshi Tokuyama, Masahiko Isaka
Journal of Antibiotics 71 (3) 351-358 2018/03/01
Publisher:
Nature Publishing Group
DOI：
10.1038/s41429-017-0008-9
ISSN：
1881-1469 0021-8820
-
A cell-targeted non-cytotoxic fluorescent nanogel thermometer created with an imidazolium-containing cationic radical initiator.
Peer-reviewed
Uchiyama S, Tsuji T, Kawamoto K, Okano K, Fukatsu E, Noro T, Ikado K, Yamada S, Shibata Y, Hayashi T, Inada N, Kato M, Koizumi H, Tokuyama H
Angewandte Chemie 130 5511-5515 2018
DOI：
10.1002/ange.201801495
-
One-Pot Reductive Allylation of Amides by Using a Combination of Titanium Hydride and an Allylzinc Reagent: Application to a Total Synthesis of (-)-Castoramine
Peer-reviewed
Itabashi, S., Shimomura, M., Sato, M., Azuma, H., Okano, K., Sakata, J., Tokuyama, H.
Synlett 29 (13) 1786-1790 2018
DOI：
10.1055/s-0037-1610435
-
Synthetic studies toward isoschizogamine: Construction of pentacyclic core structure
Peer-reviewed
Sugimoto, K., Fujiwara, H., Takada, A., Kim, D.-G., Ueda, H., Tokuyama, H.
Heterocycles 97 (2) 1028-1049 2018
DOI：
10.3987/COM-18-S(T)85
-
AgNTf2-Mediated Allylation with Allylsilanes at C3a-Position of Hexahydropyrroloindoles: Application to Total Syntheses of Amauromine Alkaloids
Peer-reviewed
Hiroyuki Hakamata, Soichiro Sato, Hirofumi Ueda, Hidetoshi Tokuyama
Organic Letters 19 (19) 5308-5311 2017/10/06
DOI：
10.1021/acs.orglett.7b02602
ISSN：
1523-7060
eISSN：
1523-7052
-
AgNTf2-MEDIATED ARYLATION OF BROMOPYRROLOINDOLINES
Peer-reviewed
Soichiro Sato, Azusa Hirayama, Tohma Adachi, Daichi Kawauchi, Hirofumi Ueda, Hidetoshi Tokuyama
HETEROCYCLES 94 (10) 1940-1957 2017/10
DOI：
10.3987/COM-17-13777
ISSN：
0385-5414
eISSN：
1881-0942
-
Total Synthesis of Actinophyllic Acid
Peer-reviewed
Yoshii, Y., Tokuyama, H., Chen, D.Y.-K.
Angewandte Chemie - International Edition 56 (40) 12277-12281 2017/09/25
DOI：
10.1002/anie.201706312
ISSN：
1433-7851
eISSN：
1521-3773
-
Total Synthesis of (−)-Histrionicotoxin through a Stereoselective Radical Translocation–Cyclization Reaction
Peer-reviewed
Sato, M., Azuma, H., Daigaku, A., Sato, S., Takasu, K., Okano, K., Tokuyama, H.
Angewandte Chemie - International Edition 56 (4) 1087-1091 2017/01/19
DOI：
10.1002/anie.201609941
ISSN：
1433-7851
eISSN：
1521-3773
-
Total Syntheses of (+)-T988 B and (+)-T988 C through the AgNTf<inf>2</inf>-Mediated Coupling of Bromopyrroloindoline with Indole
Peer-reviewed
Sato, S., Hirayama, A., Ueda, H., Tokuyama, H.
Asian Journal of Organic Chemistry 6 (1) 54-58 2017/01
DOI：
10.1002/ajoc.201600474
ISSN：
2193-5807
eISSN：
2193-5815
-
An Obtuse-angled Corner Unit for Fluctuating Carbon Nanohoops
Peer-reviewed
Zhe Sun, Naoya Miyamoto, Sota Sato, Hidetoshi Tokuyama, Hiroyuki Isobe
CHEMISTRY-AN ASIAN JOURNAL 12 (2) 271-275 2017/01
DOI：
10.1002/asia.201601614
ISSN：
1861-4728
eISSN：
1861-471X
-
Structural Determination of (-)-SCH 64874 and Hirsutellomycin by Semisynthesis
Peer-reviewed
Hidetoshi Tokuyama, Kaori Yamada, Hideto Fujiwara, Juri Sakata, Kentaro Okano, Malipan Sappan, Masahiko Isaka
JOURNAL OF ORGANIC CHEMISTRY 82 (1) 353-371 2017/01
DOI：
10.1021/acs.joc.6b02452
ISSN：
0022-3263
-
Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc(2)O
Peer-reviewed
Atsushi Umehara, Hirofumi Ueda, Hidetoshi Tokuyama
JOURNAL OF ORGANIC CHEMISTRY 81 (22) 11444-11453 2016/11
DOI：
10.1021/acs.joc.6b02097
ISSN：
0022-3263
-
Bioinspired Total Synthesis of the Dimeric Indole Alkaloid (+)-Haplophytine by Direct Coupling and Late-Stage Oxidative Rearrangement
Peer-reviewed
Hitoshi Satoh, Ken-ichi Ojima, Hirofumi Ueda, Hidetoshi Tokuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55 (48) 15157-15161 2016/11
DOI：
10.1002/anie.201609285
ISSN：
1433-7851
eISSN：
1521-3773
-
Convergent Synthesis of 2-Aryl-Substituted Quinolines by Gold-Catalyzed Cascade Reaction
Peer-reviewed
Hirofumi Ueda, Minami Yamaguchi, Hidetoshi Tokuyama
CHEMICAL & PHARMACEUTICAL BULLETIN 64 (7) 824-829 2016/07
DOI：
10.1248/cpb.c16-00193
ISSN：
0009-2363
-
Conversion of Vindoline into 11-Mesyloxytabersonine
Peer-reviewed
Yuki Han-ya, Tomohiko Inui, Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
CHEMICAL & PHARMACEUTICAL BULLETIN 64 (7) 800-804 2016/07
DOI：
10.1248/cpb.c16-00175
ISSN：
0009-2363
-
Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem-catalyzed pyrrole synthesis
Peer-reviewed
Minami Yamaguchi, Daichi Itagaki, Hirofumi Ueda, Hidetoshi Tokuyama
JOURNAL OF ANTIBIOTICS 69 (4) 253-258 2016/04
DOI：
10.1038/ja.2016.13
ISSN：
0021-8820
-
Synthetic Studies on Acochlearine: Construction of the A/B/C/E/F Ring System
Peer-reviewed
Kosuke Fujioka, Naoya Miyamoto, Hiroki Toya, Kentaro Okano, Hidetoshi Tokuyama
SYNLETT 27 (4) 621-625 2016/03
DOI：
10.1055/s-0035-1560384
ISSN：
0936-5214
eISSN：
1437-2096
-
Synthesis of Substituted Quinolizidines via a Gold-Catalyzed Double Cyclization Cascade
Peer-reviewed
Shiori Nonaka, Kenji Sugimoto, Hirofumi Ueda, Hidetoshi Tokuyama
ADVANCED SYNTHESIS & CATALYSIS 358 (3) 380-385 2016/02
DOI：
10.1002/adsc.201500907
ISSN：
1615-4150
eISSN：
1615-4169
-
Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
Peer-reviewed
Junko Morita, Kuniyuki Kano, Kazuki Kato, Hiroyuki Takita, Hideki Sakagami, Yasuo Yamamoto, Emiko Mihara, Hirofumi Ueda, Takanao Sato, Hidetoshi Tokuyama, Hiroyuki Arai, Hiroaki Asou, Junichi Takagi, Ryuichiro Ishitani, Hiroshi Nishimasu, Osamu Nureki, Junken Aoki
SCIENTIFIC REPORTS 6 20995 2016/02
DOI：
10.1038/srep20995
ISSN：
2045-2322
-
DIBALH-mediated reductive ring-expansion reaction of cyclic ketoxime
Peer-reviewed
Imaizumi, T., Okano, K., Tokuyama, H.
Organic Syntheses 93 1-13 2016
Publisher:
Organic Syntheses
DOI：
10.1002/0471264229.os093.01
-
Trichloroboron-promoted deprotection of phenolic benzyl ether using pentamethylbenzene as a non Lewis-basic cation scavenger
Peer-reviewed
Shun Okaya, Keiichiro Okuyama, Kentaro Okano, Hidetoshi Tokuyama
Organic Syntheses 93 63-74 2016
Publisher:
Wiley Blackwell
DOI：
10.15227/orgsyn.093.0063
ISSN：
1600-0730 0078-6209
-
Total Synthesis of (+)-MPC1001B
Peer-reviewed
Taichi Kurogi, Shun Okaya, Hideto Fujiwara, Kentaro Okano, Hidetoshi Tokuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55 (1) 283-287 2016/01
DOI：
10.1002/anie.201507830
ISSN：
1433-7851
eISSN：
1521-3773
-
Total Synthesis of (-)-Isoschizogamine
Peer-reviewed
Akihiro Takada, Hiroaki Fujiwara, Kenji Sugimoto, Hirofumi Ueda, Hidetoshi Tokuyama
CHEMISTRY-A EUROPEAN JOURNAL 21 (46) 16400-16403 2015/11
DOI：
10.1002/chem.201503606
ISSN：
0947-6539
eISSN：
1521-3765
-
Total synthesis of (-)-rhazinilam using 1,3-dipolar cycloaddition of optically active miinchnone intermediate
Invited
Peer-reviewed
Kenji Sugimoto, Yuta Miyakawa, Hidetoshi Tokuyama
TETRAHEDRON 71 (22) 3619-3624 2015/06
DOI：
10.1016/j.tet.201432.018
ISSN：
0040-4020
-
A concise total synthesis of (-)-indolactam V
Peer-reviewed
Toshiharu Noji, Kentaro Okano, Hidetoshi Tokuyama
TETRAHEDRON 71 (23) 3833-3837 2015/06
DOI：
10.1016/j.tet.2015.04.015
ISSN：
0040-4020
-
STEREOCHEMISTRY OF VINYLOGOUS RUBOTTOM OXIDATION OF PROLINE-FUSED CYCLOHEXADIENOL SILYL ETHER
Peer-reviewed
Kentaro Okano, Shun Okaya, Taichi Kurogi, Hideto Fujiwara, Hidetoshi Tokuyama
HETEROCYCLES 90 (2) 1299-1308 2015/01
DOI：
10.3987/COM-14-S(K)62
ISSN：
0385-5414
eISSN：
1881-0942
-
Synthetic studies toward penitrem E: enantiocontrolled construction of B-E rings
Peer-reviewed
Yu Yoshii, Takanori Otsu, Norihiko Hosokawa, Kiyosei Takasu, Kentaro Okano, Hidetoshi Tokuyama
CHEMICAL COMMUNICATIONS 51 (6) 1070-1073 2015
DOI：
10.1039/c4cc08505a
ISSN：
1359-7345
eISSN：
1364-548X
-
Synthetic studies on lycopodine: construction of hexahydrojulolidine core by intramolecular Mannich reaction
Peer-reviewed
Takanao Sato, Hirofumi Ueda, Hidetoshi Tokuyama
TETRAHEDRON LETTERS 55 (52) 7177-7180 2014/12
DOI：
10.1016/j.tetlet.2014.10.150
ISSN：
0040-4039
-
Total Synthesis of (-)-Haouamine B Pentaacetate and Structural Revision of Haouamine B
Peer-reviewed
Yuichi Momoi, Kei-ichiro Okuyama, Hiroki Toya, Kenji Sugimoto, Kentaro Okano, Hidetoshi Tokuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53 (48) 13215-13219 2014/11
DOI：
10.1002/anie.201407686
ISSN：
1433-7851
eISSN：
1521-3773
-
Stereocontrolled total synthesis and biological evaluation of (-)- and (+)-petrosin and its derivatives
Peer-reviewed
Hiroki Toya, Takahito Satoh, Kentaro Okano, Kiyosei Takasu, Masataka Ihara, Atsushi Takahashi, Haruo Tanaka, Hidetoshi Tokuyama
TETRAHEDRON 70 (43) 8129-8141 2014/10
DOI：
10.1016/j.tet.2014.08.009
ISSN：
0040-4020
-
Generation of Aryl Grignard Reagents from Arene Chromium Tricarbonyl Complexes by Mg(TMP)(2)center dot 2LiCl and Their Application to Murahashi Coupling
Peer-reviewed
Yuichi Momoi, Kentaro Okano, Hidetoshi Tokuyama
SYNLETT 25 (17) 2503-2507 2014/10
DOI：
10.1055/s-0034-1379205
ISSN：
0936-5214
eISSN：
1437-2096
-
Autotandem Catalysis: Synthesis of Pyrroles by Gold-Catalyzed Cascade Reaction
Peer-reviewed
Hirofumi Ueda, Minami Yamaguchi, Hiroshi Kameya, Kenji Sugimoto, Hidetoshi Tokuyama
ORGANIC LETTERS 16 (18) 4948-4951 2014/09
DOI：
10.1021/ol5024695
ISSN：
1523-7060
eISSN：
1523-7052
-
Acetic Acid Promoted Metal-Free Aerobic Carbon-Carbon Bond Forming Reactions at alpha-Position of Tertiary Amines
Peer-reviewed
Hirofumi Ueda, Kei Yoshida, Hidetoshi Tokuyama
ORGANIC LETTERS 16 (16) 4194-4197 2014/08
DOI：
10.1021/ol5018883
ISSN：
1523-7060
eISSN：
1523-7052
-
Total Syntheses of Leuconoxine, Leuconodine B, and Melodinine E by Oxidative Cyclic Aminal Formation and Diastereoselective Ring-Closing Metathesis
Peer-reviewed
Atsushi Umehara, Hirofumi Ueda, Hidetoshi Tokuyama
ORGANIC LETTERS 16 (9) 2526-2529 2014/05
DOI：
10.1021/ol500903e
ISSN：
1523-7060
eISSN：
1523-7052
-
Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo
Peer-reviewed
Keita Nakanaga, Kotaro Hama, Kuniyuki Kano, Takanao Sato, Hiroshi Yukiura, Asuka Inoue, Daisuke Saigusa, Hidetoshi Tokuyama, Yoshihisa Tomioka, Hiroshi Nishina, Atsuo Kawahara, Junken Aoki
JOURNAL OF BIOCHEMISTRY 155 (4) 235-241 2014/04
DOI：
10.1093/jb/mvt114
ISSN：
0021-924X
eISSN：
1756-2651
-
Synthesis of a Human Urate Transporter-1 Inhibitor, an Arginine Vasopressin Antagonist, and a 17 beta-Hydroxysteroid Dehydrogenase Type-3 Inhibitor, Using Ring-Expansion of Cyclic Ketoximes with DIBALH
Peer-reviewed
Hidetsura Cho, Yusuke Iwama, Kentaro Okano, Hidetoshi Tokuyama
CHEMICAL & PHARMACEUTICAL BULLETIN 62 (4) 354-363 2014/04
DOI：
10.1248/cpb.c13-00961
ISSN：
0009-2363
-
FORMATION OF XANTHONE OXIME AND RELATED COMPOUNDS USING A COMBINATION OF tert-BUTYL NITRITE AND POTASSIUM HEXAMETHYLDISILAZIDE
Peer-reviewed
Yusuke Iwama, Takahiro Noro, Kentaro Okano, Hidetsura Cho, Hidetoshi Tokuyama
HETEROCYCLES 88 (2) 1433-1444 2014/01
DOI：
10.3987/COM-13-S(S)110
ISSN：
0385-5414
eISSN：
1881-0942
-
Total synthesis of PDE-I and -II by copper-mediated double aryl amination This paper is dedicated to Professor Teruaki Mukaiyama in celebration of the 40th anniversary of the Mukaiyama aldol reaction
Peer-reviewed
Kentaro Okano, Nakako Mitsuhashi, Hidetoshi Tokuyama
Tetrahedron 69 (51) 10946-10954 2013/12/23
DOI：
10.1016/j.tet.2013.10.057
ISSN：
0040-4020 1464-5416
-
Synthetic studies on isoschizogamine: construction of [3.3.1] bicyclic aminal core by using oxidative skeletal rearrangement
Peer-reviewed
Hirofumi Ueda, Akihiro Takada, Hidetoshi Tokuyama
TETRAHEDRON LETTERS 54 (52) 7115-7118 2013/12
DOI：
10.1016/j.tetlet.2013.10.083
ISSN：
0040-4039
-
Formal Synthesis of Hepatitis C Virus NS5B Polymerase Inhibitor
Peer-reviewed
Takahiro Noro, Kentaro Okano, Hidetoshi Tokuyama
SYNLETT 24 (16) 2143-2147 2013/10
DOI：
10.1055/s-0033-1339522
ISSN：
0936-5214
eISSN：
1437-2096
-
Enantiocontrolled Total Synthesis of (-)-Mersicarpine
Peer-reviewed
Yusuke Iwama, Kentaro Okano, Kenji Sugimoto, Hidetoshi Tokuyama
CHEMISTRY-A EUROPEAN JOURNAL 19 (28) 9325-9334 2013/07
DOI：
10.1002/chem.201301040
ISSN：
0947-6539
eISSN：
1521-3765
-
Protecting-Group-Free Total Synthesis of (-)-Rhazinilam and (-)-Rhazinicine using a Gold-Catalyzed Cascade Cyclization
Peer-reviewed
Kenji Sugimoto, Kazuki Toyoshima, Shiori Nonaka, Kenta Kotaki, Hirofumi Ueda, Hidetoshi Tokuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 (28) 7168-7171 2013/07
DOI：
10.1002/anie.201303067
ISSN：
1433-7851
eISSN：
1521-3773
-
Construction of Dibenzazocine Skeleton by Regiocontrolled Ring-Expansion Reaction of Cyclic Oxime with DIBAL-H: Facile Synthesis of 17 beta-Hydroxysteroid Dehydrogenase Type 3 Inhibitor
Peer-reviewed
Hidetsura Cho, Yusuke Iwama, Kentaro Okano, Hidetoshi Tokuyama
SYNLETT 24 (7) 813-816 2013/04
DOI：
10.1055/s-0032-1318489
ISSN：
0936-5214
-
Synthesis of Substituted Indoline and Carbazole by Benzyne-Mediated Cyclization-Functionalization
Peer-reviewed
Toshiharu Noji, Hideto Fujiwara, Kentaro Okano, Hidetoshi Tokuyama
ORGANIC LETTERS 15 (8) 1946-1949 2013/04
DOI：
10.1021/ol400597f
ISSN：
1523-7060
-
Divergent total synthesis of (-)-aspidophytine and its congeners via Fischer indole synthesis
Peer-reviewed
Hitoshi Satoh, Hirofumi Ueda, Hidetoshi Tokuyama
TETRAHEDRON 69 (1) 89-95 2013/01
DOI：
10.1016/j.tet.2012.10.060
ISSN：
0040-4020
-
Synthetic studies on strictamine: unexpected oxidation of tertiary amine in Ru-catalyzed ring-closing olefin metathesis
Peer-reviewed
Yoshiyuki Komatsu, Kei Yoshida, Hirofumi Ueda, Hidetoshi Tokuyama
TETRAHEDRON LETTERS 54 (5) 377-380 2013/01
DOI：
10.1016/j.tetlet.2012.10.129
ISSN：
0040-4039
-
Toward the Total Synthesis of (+/-)-Andrastin C
Peer-reviewed
Rei Okamoto, Kazutaka Takeda, Hidetoshi Tokuyama, Masataka Ihara, Masahiro Toyota
JOURNAL OF ORGANIC CHEMISTRY 78 (1) 93-103 2013/01
DOI：
10.1021/jo301948h
ISSN：
0022-3263
-
Total synthesis of makaluvamine A/D, damirone B, batzelline C, makaluvone, and isobatzelline C featuring one-pot benzyne-mediated cyclization-functionalization
Peer-reviewed
Takashi Oshiyama, Takahito Satoh, Kentaro Okano, Hidetoshi Tokuyama
TETRAHEDRON 68 (46) 9376-9383 2012/11
DOI：
10.1016/j.tet.2012.09.034
ISSN：
0040-4020
-
Synthesis and biological evaluation of optically active Ki16425
Peer-reviewed
Takanao Sato, Kenji Sugimoto, Asuka Inoue, Shinichi Okudaira, Junken Aoki, Hidetoshi Tokuyama
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22 (13) 4323-4326 2012/07
DOI：
10.1016/j.bmcl.2012.05.012
ISSN：
0960-894X
-
Ring-Expansion Reaction of Oximes with Aluminum Reductants
Peer-reviewed
Hidetsura Cho, Yusuke Iwama, Nakako Mitsuhashi, Kenji Sugimoto, Kentaro Okano, Hidetoshi Tokuyama
MOLECULES 17 (6) 7348-7355 2012/06
DOI：
10.3390/molecules17067348
ISSN：
1420-3049
-
Concise Total Synthesis of (-)-Mersicarpine
Peer-reviewed
Yusuke Iwama, Kentaro Okano, Kenji Sugimoto, Hidetoshi Tokuyama
ORGANIC LETTERS 14 (9) 2320-2322 2012/05
DOI：
10.1021/ol300735g
ISSN：
1523-7060
-
Facile isomerization of silyl enol ethers catalyzed by triflic imide and its application to one-pot isomerization-(2+2) cycloaddition
Peer-reviewed
Kazato Inanaga, Yu Ogawa, Yuuki Nagamoto, Akihiro Daigaku, Hidetoshi Tokuyama, Yoshiji Takemoto, Kiyosei Takasu
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 8 658-661 2012/04
DOI：
10.3762/bjoc.8.73
ISSN：
1860-5397
-
SYNTHETIC STUDIES ON PASPALINE: LEWIS ACID-MEDIATED SEQUENTIAL CONSTRUCTION OF A-E RING SKELETON
Peer-reviewed
Kentaro Okano, Yu Yoshii, Hidetoshi Tokuyama
HETEROCYCLES 84 (2) 1325-1334 2012/01
DOI：
10.3987/COM-11-S(P)67
ISSN：
0385-5414
-
Total synthesis of batzelline C and isobatzelline C
Peer-reviewed
Takashi Oshiyama, Takahito Satoh, Kentaro Okano, Hidetoshi Tokuyama
RSC ADVANCES 2 (12) 5147-5149 2012
DOI：
10.1039/c2ra20604h
ISSN：
2046-2069
-
Total Synthesis of (-)-Acetylaranotin
Peer-reviewed
Hideto Fujiwara, Taichi Kurogi, Shun Okaya, Kentaro Okano, Hidetoshi Tokuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 51 (52) 13062-13065 2012
DOI：
10.1002/anie.201207307
ISSN：
1433-7851
-
43 Total Synthesis of Dictyodendrins A-E(Oral Presentation)
Okano Kentaro, Fujiwara Hideto, Noji Toshiharu, Fukuyama Tohru, Tokuyama Hidetoshi
Symposium on the Chemistry of Natural Products, symposium papers (53) 253-258 2011/09/02
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.53.0_253
-
Total synthesis of tryprostatins A and B
Peer-reviewed
Takayuki Yamakawa, Eiji Ideue, Yuzo Iwaki, Ayumu Sato, Hidetoshi Tokuyama, Jun Shimokawa, Tohru Fukuyama
TETRAHEDRON 67 (35) 6547-6560 2011/09
DOI：
10.1016/j.tet.2011.05.112
ISSN：
0040-4020
-
Synthesis of Acylsilanes by Palladium-catalyzed Cross-coupling Reaction of Thiol Esters and Silylzinc Chlorides
Peer-reviewed
Hiroki Azuma, Kentaro Okano, Hidetoshi Tokuyama
CHEMISTRY LETTERS 40 (9) 959-961 2011/09
DOI：
10.1246/cl.2011.959
ISSN：
0366-7022
eISSN：
1348-0715
-
Preparation of horner-wadsworth-emmons reagent: Methyl 2- benzyloxycarbonylamino-2-(dimethoxy-phosphinyl)acetate
Peer-reviewed
Hiroki Azuma, Kentaro Okano, Tohru Fukuyama, Hidetoshi Tokuyama
Organic Syntheses 88 152-161 2011/07/01
Publisher:
Wiley Blackwell
DOI：
10.15227/orgsyn.088.0152
ISSN：
1600-0730 0078-6209
-
An intramolecular amination of aryl halides with a combination of copper (I) iodide and cesium acetate: Preparation of 5,6-dimethoxyindole-1,2- dicarboxylic acid 1-benzyl ester 2-methyl ester
Peer-reviewed
Toshiharu Noji, Kentaro Okano, Tohru Fukuyama, Hidetoshi Tokuyama
Organic Syntheses 88 388-397 2011/07/01
Publisher:
Wiley Blackwell
DOI：
10.15227/orgsyn.088.0388
ISSN：
1600-0730 0078-6209
-
REGIOSPECIFIC REARRANGEMENT OF HYDROXYLAMINES TO SECONDARY AMINES USING DIISOBUTYLALUMINUM HYDRIDE
Peer-reviewed
Hidetsura Cho, Kenji Sugimoto, Yusuke Iwama, Nakako Mitsuhashi, Kentaro Okano, Hidetoshi Tokuyama
HETEROCYCLES 82 (2) 1633-+ 2011/03
DOI：
10.3987/COM-10-S(E)126
ISSN：
0385-5414
-
Total Synthesis of Dictyodendrins A-E
Peer-reviewed
Hidetoshi Tokuyama, Kentaro Okano, Hideto Fujiwara, Toshiharu Noji, Tohru Fukuyama
CHEMISTRY-AN ASIAN JOURNAL 6 (2) 560-572 2011/02
DOI：
10.1002/asia.201000544
ISSN：
1861-4728
-
Synthetic Studies toward Haouamine B: Construction of Indenotetrahydropyridone Skeleton
Peer-reviewed
Kei-ichiro Okuyama, Yuichi Momoi, Kenji Sugimoto, Kentaro Okano, Hidetoshi Tokuyama
SYNLETT (1) 73-76 2011/01
DOI：
10.1055/s-0030-1259096
ISSN：
0936-5214
-
Total Synthesis of (-)-Conophylline and (-)-Conophyllidine
Peer-reviewed
Yuki Han-ya, Hidetoshi Tokuyama, Tohru Fukuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50 (21) 4884-4887 2011
DOI：
10.1002/anie.201100981
ISSN：
1433-7851
-
Enantioselective Total Synthesis of (-)- and (+)-Petrosin
Peer-reviewed
Hiroki Toya, Kentaro Okano, Kiyosei Takasu, Masataka Ihara, Atsushi Takahashi, Haruo Tanaka, Hidetoshi Tokuyama
ORGANIC LETTERS 12 (22) 5196-5199 2010/11
DOI：
10.1021/ol1022257
ISSN：
1523-7060
-
Total Synthesis of (+/-)-Lepadiformine A via Radical Translocation-Cyclization Reaction
Peer-reviewed
Manabu Fujitani, Masami Tsuchiya, Kentaro Okano, Kiyosei Takasu, Masataka Ihara, Hidetoshi Tokuyama
SYNLETT (5) 822-826 2010/03
DOI：
10.1055/s-0029-1219389
ISSN：
0936-5214
-
Regioselective Synthesis of Heterocycles Containing Nitrogen Neighboring an Aromatic Ring by Reductive Ring Expansion Using Diisobutyl aluminum Hydride and Studies on the Reaction Mechanism
Peer-reviewed
Hidetsura Cho, Yusuke Iwama, Kenji Sugimoto, Seiji Mori, Hidetoshi Tokuyama
JOURNAL OF ORGANIC CHEMISTRY 75 (3) 627-636 2010/02
DOI：
10.1021/jo902177p
ISSN：
0022-3263
-
Total synthesis of PDE-II by copper-mediated double amination
Peer-reviewed
Kentaro Okano, Nakako Mitsuhashi, Hidetoshi Tokuyama
CHEMICAL COMMUNICATIONS 46 (15) 2641-2643 2010
DOI：
10.1039/b926965g
ISSN：
1359-7345
-
Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites
Peer-reviewed
Daiki Morisaki, Hye-Sook Kim, Hiroshi Inoue, Hiroki Terauchi, Shusuke Kuge, Akira Naganuma, Yusuke Wataya, Hidetoshi Tokuyama, Masataka Ihara, Kiyosei Takasu
CHEMICAL SCIENCE 1 (2) 206-209 2010
DOI：
10.1039/c0sc00125b
ISSN：
2041-6520
-
Total Synthesis of Dictyodendrin A and B
Peer-reviewed
Kentaro Okano, Hideto Fujiwara, Toshiharu Noji, Tohru Fukuyama, Hidetoshi Tokuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 49 (34) 5925-5929 2010
DOI：
10.1002/anie.201001966
ISSN：
1433-7851
-
Total Synthesis of (+)-Haplophytine
Ueda Hirofumi, Satoh Hitoshi, Matsumoto Koji, Sugimoto Kenji, Fukuyama Tohru, Tokuyama Hidetoshi
Symposium on the Chemistry of Natural Products, symposium papers (51) 139-144 2009/09/01
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.51.0_139
-
REGIOSPECIFIC SYNTHESIS OF UNSUBSTITUTED BASIC SKELETONS OF HETEROCYCLES CONTAINING NITROGEN NEIGHBORING AN AROMATIC RING BY THE REDUCTIVE RING EXPANSION REACTION USING DIISOBUTYLALUMINUM HYDRIDE
Peer-reviewed
Hidetsura Cho, Yusuke Iwama, Kenji Sugimoto, Eunsang Kwon, Hidetoshi Tokuyama
HETEROCYCLES 78 (5) 1183-1190 2009/05
DOI：
10.3987/COM-08-11629
ISSN：
0385-5414
-
Synthesis of Lysergic Acid Methyl Ester via the Double Cyclization Strategy
Peer-reviewed
Toshiki Kurokawa, Minetaka Isomura, Hidetoshi Tokuyama, Tohru Fukuyama
SYNLETT (5) 775-778 2009/03
DOI：
10.1055/s-0028-1087948
ISSN：
0936-5214
-
TRIFLIC IMIDE CATALYZED [3+2] CYCLOADDITION OF ALDIMINES WITH alpha alpha-DIMETHYLALLYLSILANE
Peer-reviewed
Naoya Shindoh, Hidetoshi Tokuyama, Yoshiji Takemoto, Kiyosei Takasu
HETEROCYCLES 77 (1) 187-192 2009/01
DOI：
10.3987/COM-08-S(F)17
ISSN：
0385-5414
-
PALLADIUM-CATALYZED COUPLING OF N-HETEROARYL SULFIDES WITH ORGANOZINC REAGENTS
Peer-reviewed
Takahiro Koshiba, Tohru Miyazaki, Hidetoshi Tokuyama, Tohru Fukuyama
HETEROCYCLES 77 (1) 233-239 2009/01
DOI：
10.3987/COM-08-S(F)49
ISSN：
0385-5414
-
Protection of diols with 4-(tert-Butyldimethylsilyloxy)Benzylidene acetal and its deprotection: (4-((4R,5R)-4,5-diphenyl-1,3-dioxolan-2-yl)phenoxy) (tertbutyl)dimethylsilane
Peer-reviewed
Osajima, H., Fujiwara, H., Okano, K., Tokuyama, H., Fukuyama, T., Denmark, S.E., Chang, W.-T.T.
Organic Syntheses 86 130-140 2009
Publisher:
Organic Syntheses
DOI：
10.1002/0471264229.os086.14
-
Total Synthesis of (+)-Haplophytine
Peer-reviewed
Hirofumi Ueda, Hitoshi Satoh, Koji Matsumoto, Kenji Sugimoto, Tohru Fukuyama, Hidetoshi Tokuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48 (41) 7600-7603 2009
DOI：
10.1002/anie.200902192
ISSN：
1433-7851
-
A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc
Peer-reviewed
Tetsuji Kubo, Chiharu Katoh, Ken Yamada, Kentaro Okano, Hidetoshi Tokuyama, Tohru Fukuyama
TETRAHEDRON 64 (49) 11230-11236 2008/12
DOI：
10.1016/j.tet.2008.09.042
ISSN：
0040-4020
-
Auto-tandem catalysis in the synthesis of substituted quinolines from aldimines and electron-rich olefins: Cascade Povarov-hydrogen-transfer reaction
Peer-reviewed
Naoya Shindoh, Hidetoshi Tokuyama, Yoshiji Takemoto, Kiyosei Takasu
JOURNAL OF ORGANIC CHEMISTRY 73 (19) 7451-7456 2008/10
DOI：
10.1021/jo8009243
ISSN：
0022-3263
-
P-18 Synthetic Studies towards Haouamines(Poster Presentation)
Okuyama Kei-ichiro, Sugimoto Kenji, Tokuyama Hidetoshi
Symposium on the Chemistry of Natural Products, symposium papers (50) 593-598 2008/09/01
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.50.0_593
-
(2+2) cycloaddition reaction of alkyl enol ethers with acrylates by in situ generated silyl triflic imide catalyst
Peer-reviewed
Kiyosei Takasu, Yuta Miyakawa, Masataka Ihara, Hidetoshi Tokuyama
CHEMICAL & PHARMACEUTICAL BULLETIN 56 (8) 1205-1206 2008/08
DOI：
10.1248/cpb.56.1205
ISSN：
0009-2363
-
Mild debenzylation of aryl benzyl ether with BCl(3) in the presence of pentamethylbenzene as a non-Lewis-basic cation scavenger
Peer-reviewed
Kentaro Okano, Kei-ichiro Okuyama, Tohru Fukuyama, Hidetoshi Tokuyama
SYNLETT (13) 1977-1980 2008/08
DOI：
10.1055/s-2008-1077980
ISSN：
0936-5214
-
Synthesis of eudistomin C and E: Improved preparation of the indole unit
Peer-reviewed
Hiroaki Yamagishi, Koji Matsumoto, Kotaro Iwasaki, Tohru Miyazaki, Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
ORGANIC LETTERS 10 (12) 2369-2372 2008/06
DOI：
10.1021/ol800527p
ISSN：
1523-7060
-
Total synthesis of (-)-kainic acid via intramolecular Michael addition: A. Second-generation route
Peer-reviewed
Hiroshi Sakaguchi, Hidetoshi Tokuyama, Tohru Fukuyama
ORGANIC LETTERS 10 (9) 1711-1714 2008/05
DOI：
10.1021/ol800328q
ISSN：
1523-7060
-
Total synthesis of (+)-yatakemycin
Peer-reviewed
Kentaro Okano, Hidetoshi Tokuyama, Tohru Fukuyama
CHEMISTRY-AN ASIAN JOURNAL 3 (2) 296-309 2008
DOI：
10.1002/asia.200700282
ISSN：
1861-4728
-
Synthesis of vinyloxazolidinones by palladium-catalyzed CO2-recycling reaction of 4-(benzylamino)-2-butenyl carbonates
Peer-reviewed
Masahiro Yoshida, Yusuke Ohsawa, Kenji Sugimoto, Hidetoshi Tokuyama, Masataka Ihara
TETRAHEDRON LETTERS 48 (49) 8678-8682 2007/12
DOI：
10.1016/j.tetlet.2007.10.020
ISSN：
0040-4039
-
Synthetic studies on haplophytine: Protective-group-controlled rearrangement
Peer-reviewed
Koji Matsumoto, Hidetoshi Tokuyama, Tohru Fukuyama
SYNLETT (20) 3137-3140 2007/12
DOI：
10.1055/s-2007-990911
ISSN：
0936-5214
-
Synthesis of (+)-vinblastine and its analogues
Peer-reviewed
Tohru Miyazaki, Satoshi Yokoshirna, Siro Simizu, Hiroyuki Osada, Hidetoshi Tokuyama, Tohru Fukuyama
ORGANIC LETTERS 9 (23) 4737-4740 2007/11
DOI：
10.1021/ol702040y
ISSN：
1523-7060
-
Cascade and one-pot processes providing substituted quinolines from aldimines and allylsilanes: auto-tandem catalysis of triflic imide
Peer-reviewed
Naoya Shindoh, Hidetoshi Tokuyama, Kiyosel Takasu
TETRAHEDRON LETTERS 48 (27) 4749-4753 2007/07
DOI：
10.1016/j.tetlet.2007.05.032
ISSN：
0040-4039
-
A novel indole synthesis via conjugate addition of pyrrolidine to o-nitrophenylacetylenes
Peer-reviewed
Tokuyama, H., Makido, T., Han-ya, Y., Fukuyama, T.
Heterocycles 72 191-197 2007/05
-
Stereocontrolled total synthesis of (-)-kainic acid
Peer-reviewed
Hiroshi Sakaguchi, Hidetoshi Tokuyama, Tohru Fukuyama
ORGANIC LETTERS 9 (9) 1635-1638 2007/04
DOI：
10.1021/ol0631197
ISSN：
1523-7060
-
Design and synthesis of thiazoline-thiazole hybrid macrocycles possessing strong binding affinity to Pb2+ and Cd2+
Peer-reviewed
Fu She Han, Hidetoshi Tokuyama, Tohru Fukuyama
CHEMICAL COMMUNICATIONS (33) 3444-3446 2007
DOI：
10.1039/b707904d
ISSN：
1359-7345
-
Novel structural motifs consisting of chiral thiazolines: Synthesis, molecular recognition, and anticancer activity
Peer-reviewed
Fu She Han, Hiroyuki Osajima, Mui Cheung, Hidetoshi Tokuyama, Tohru Fukuyama
CHEMISTRY-A EUROPEAN JOURNAL 13 (11) 3026-3038 2007
DOI：
10.1002/chem.200601446
ISSN：
0947-6539
-
Catalytic imino Diels-Alder reaction by triflic imide and its application to one-pot synthesis from three components
Peer-reviewed
Kiyosei Takasu, Naoya Shindoh, Hidetoshi Tokuyama, Masataka Ihara
TETRAHEDRON 62 (51) 11900-11907 2006/12
DOI：
10.1016/j.tet.2006.09.092
ISSN：
0040-4020
-
P-37 Synthetic Studies toward Protein Farnesyltransferase Inhibitor Andrastins
Okamoto Rei, Tokuyama Hidetoshi, Ihara Masataka, Toyota Masahiro
Symposium on the Chemistry of Natural Products, symposium papers (48) 349-354 2006/09/15
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.48.0_349
-
30 Total Synthesis of (+)-Yatakemycin
Okano Kentaro, Tokuyama Hidetoshi, Fukuyama Tohru
Symposium on the Chemistry of Natural Products, symposium papers (48) 175-180 2006/09/15
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.48.0_175
-
P-125 SYNTHETIC STUDIES ON PLAKINIDINE A
Seki Atsushi, Osajima Hiroyuki, Kawano Manami, Tokuyama Hidetoshi, Fukuyama Tohru
International Symposium on the Chemistry of Natural Products 2006 "P-125" 2006/07/23
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/intnaturalprod.2006.0__P-125_
-
Total synthesis of (+)-yatakemycin
Peer-reviewed
Kentaro Okano, Hidetoshi Tokuyama, Tohru Fukuyama
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 128 (22) 7136-7137 2006/06
DOI：
10.1021/ja0619455
ISSN：
0002-7863
-
Synthesis of chiral cyclic oligothiazolines: a novel structural motif for a macrocyclic molecule
Peer-reviewed
FS Han, H Osajima, M Cheung, H Tokuyama, T Fukuyama
CHEMICAL COMMUNICATIONS (16) 1757-1759 2006
DOI：
10.1039/b601628f
ISSN：
1359-7345
-
Synthesis of tetrahydro-beta-carbolines via radical cyclization of 2-alkenylthioanilides
Peer-reviewed
M Iwadate, T Yamashita, H Tokuyama, T Fukuyama
HETEROCYCLES 66 241-249 2005/12
DOI：
10.3987/COM-05-S(K)11
ISSN：
0385-5414
-
Stereocontrolled total synthesis of (-)-Eudistomin C
Peer-reviewed
T Yamashita, N Kawai, H Tokuyama, T Fukuyama
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127 (43) 15038-15039 2005/11
DOI：
10.1021/ja055832h
ISSN：
0002-7863
-
Stereocontrolled total synthesis of (-)-kainic acid. regio- and stereoselective lithiation of pyrrolidine ring with the (+)-sparteine surrogate
Peer-reviewed
Y Morita, H Tokuyama, T Fukuyama
ORGANIC LETTERS 7 (20) 4337-4340 2005/09
DOI：
10.1021/ol051408+
ISSN：
1523-7060
-
Synthesis of 2,3-dialkylindoles from 2-alkenylphenylisocyanides and Imines by silyltelluride- and tin hydride-mediated sequential radical reactions
Peer-reviewed
M Kotani, S Yamago, A Satoh, H Tokuyama, T Fukuyama
SYNLETT (12) 1893-1896 2005/08
DOI：
10.1055/s-2005-871931
ISSN：
0936-5214
-
Acceleration of reaction by microwave irradiation
Tokuyama, H., Nakamura, M.
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 63 (5) 2005
-
Fluorescence enhancement by hydroperoxides based on a change in the intramolecular charge transfer character of benzofurazan
Peer-reviewed
M Onoda, H Tokuyama, S Uchiyama, K Mawatari, T Santa, K Kaneko, K Imai, K Nakagomi
CHEMICAL COMMUNICATIONS (14) 1848-1850 2005
DOI：
10.1039/b500419e
ISSN：
1359-7345
-
36(D-6) Total Synthesis of (-)-Strychnine
Kaburagi Yosuke, Tokuyama Hidetoshi, Fukuyama Tohru
Symposium on the Chemistry of Natural Products, symposium papers (46) 191-196 2004/10/01
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.46.0_191
-
Thermal and palladium-catalyzed [3+2] synthesis of cyclopentadienone acetals from cyclopropenone acetals and acetylenes
Peer-reviewed
H Isobe, S Sato, T Tanaka, H Tokuyama, E Nakamura
ORGANIC LETTERS 6 (20) 3569-3571 2004/09
DOI：
10.1021/ol0483450
ISSN：
1523-7060
-
Total synthesis of (-)-strychnine
Peer-reviewed
Y Kaburagi, H Tokuyama, T Fukuyama
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 126 (33) 10246-10247 2004/08
DOI：
10.1021/ja046407b
ISSN：
0002-7863
-
Stereocontrolled total synthesis of (+)-vincristine
Peer-reviewed
T Kuboyama, S Yokoshima, H Tokuyama, T Fukuyama
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (33) 11966-11970 2004/08
DOI：
10.1073/pnas.0401323101
ISSN：
0027-8424
-
4-(tert-butyldimethylsilyloxy)benzylidene acetal: a novel benzylidene-type protecting group for 1,2-diols
Peer-reviewed
Y Kaburagi, H Osajima, K Shimada, H Tokuyama, T Fukuyama
TETRAHEDRON LETTERS 45 (19) 3817-3821 2004/05
DOI：
10.1016/j.tetlet.2004.03.065
ISSN：
0040-4039
-
Enantioselective total synthesis of FR900482
Peer-reviewed
M Suzuki, M Kambe, H Tokuyama, T Fukuyama
JOURNAL OF ORGANIC CHEMISTRY 69 (8) 2831-2843 2004/04
DOI：
10.1021/jo049862z
ISSN：
0022-3263
-
New Odorless Protocols for the Synthesis of Aldehydes and Ketones from Thiol Esters
Peer-reviewed
T. Miyazaki, Y. Han-ya, H. Tokuyama, T. Fukuyama
Synlett 477-480 2004/03
DOI：
10.1055/s-2004-815427
-
Synthesis of secondary arylamines through copper-mediated intermolecular aryl amination
Peer-reviewed
K Okano, H Tokuyama, T Fukuyama
ORGANIC LETTERS 5 (26) 4987-4990 2003/12
DOI：
10.1021/ol035942y
ISSN：
1523-7060
-
Stereocontrolled total synthesis of (-)-aspidophytine
Peer-reviewed
S Sumi, K Matsumoto, H Tokuyama, T Fukuyama
TETRAHEDRON 59 (43) 8571-8587 2003/10
DOI：
10.1016/j.tet.2003.09.005
ISSN：
0040-4020
-
66(P-47) Synthetic Studies on (+)-Lysergic Acid
Kurokawa Toshiki, Isomura Minetaka, Tokuyama Hidetoshi, Fukuyama Tohru
Symposium on the Chemistry of Natural Products, symposium papers (45) 389-394 2003/09/01
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.45.0_389
-
Total synthesis of the duocarmycins
Peer-reviewed
K Yamada, T Kurokawa, H Tokuyama, T Fukuyama
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125 (22) 6630-6631 2003/06
DOI：
10.1021/ja035303i
ISSN：
0002-7863
-
First fluorescent photoinduced electron transfer (PET) reagent for hydroperoxides
Peer-reviewed
M Onoda, S Uchiyama, A Endo, H Tokuyama, T Santa, K Imal
ORGANIC LETTERS 5 (9) 1459-1461 2003/05
DOI：
10.1021/ol0342150
ISSN：
1523-7060
-
Enantioselective total synthesis of aspidophytine
Peer-reviewed
S Sumi, K Matsumoto, H Tokuyama, T Fukuyama
ORGANIC LETTERS 5 (11) 1891-1893 2003/05
DOI：
10.1021/ol034445e
ISSN：
1523-7060
-
Stereoselective formation of a β-lactam fused oxathiazepin: A synthetic approach to eudistomins
Peer-reviewed
Yamashita, T., Tokuyama, H., Fukuyama, T.
Synlett (5) 2003/05
-
A novel palladium-catalyzed coupling of thiol esters with 1-alkynes
Peer-reviewed
Hidetoshi Tokuyama, Tohru Miyazaki, Satoshi Yokoshima, Tohru Fukuyama
Synlett (10) 1512-1514 2003
Publisher:
Georg Thieme Verlag
DOI：
10.1055/s-2003-40861
ISSN：
0936-5214
-
Transformation of primary amines to N-monoalkylhydroxylamines: N-hydroxy-(S)-1-phenylethylamine oxalate: [(Benzenemethanamine, N-hydroxy--methyl-, (S)-, ethanedioate)]
Peer-reviewed
Hidetoshi Tokuyama, Takeshi Kuboyama, Tohru Fukuyama, Scott E. Denmark, Jeromy J. Cottell
Organic Syntheses 80 207-218 2003
Publisher:
Wiley Blackwell
DOI：
10.15227/orgsyn.080.0207
ISSN：
1600-0730 0078-6209
-
Stereocontrolled total synthesis of (+)-vinblastine
Invited
Peer-reviewed
Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama, Tohru Fukuyama
Pure and Applied Chemistry 75 (1) 29-38 2003/01/01
Publisher:
Walter de Gruyter GmbH
DOI：
10.1351/pac200375010029
ISSN：
0033-4545
-
Synthesis of 2,3-disubstituted indoles by radical cyclization with hypophosphorous acid and its application to total synthesis of (±)-catharanthine
Peer-reviewed
Reding, M.T., Kaburagi, Y., Tokuyama, H., Fukuyama, T.
Heterocycles 56 (1-2) 313-330 2002/10
-
A mild copper-mediated intramolecular amination of aryl halides
Peer-reviewed
Yamada, K., Kubo, T., Tokuyama, H., Fukuyama, T.
Synlett (2) 231-234 2002/09
-
Estrogen receptor binding assay method for endocrine disruptors using fluorescence polarization
Peer-reviewed
K Ohno, T Fukushima, T Santa, N Waizumi, H Tokuyama, M Maeda, K Imai
ANALYTICAL CHEMISTRY 74 (17) 4391-4396 2002/09
DOI：
10.1021/ac020088u
ISSN：
0003-2700
-
Reduction of ethanethiol esters to aldehydes
Peer-reviewed
Tokuyama, H., Yokoshima, S., Lin, S.-C., Li, L., Fukuyama, T.
Synthesis (8) 1121-1123 2002/08
DOI：
10.1055/s-2002-31969
-
Stereocontrolled total synthesis of (+)-vinblastine
Peer-reviewed
S Yokoshima, T Ueda, S Kobayashi, A Sato, T Kuboyama, H Tokuyama, T Fukuyama
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124 (10) 2137-2139 2002/03
DOI：
10.1021/ja0177049
ISSN：
0002-7863
-
A novel oxidative transformation of alpha-aminonitriles to amides
Peer-reviewed
S Yokoshima, T Kubo, H Tokuyama, T Fukuyama
CHEMISTRY LETTERS (2) 122-123 2002/02
ISSN：
0366-7022
eISSN：
1348-0715
-
A Novel Conversion of alpha-Aminonitrile to Amide
Peer-reviewed
S. Yokoshima, T. Kubo, H. Tokuyama, T. Fukuyama
Chemistry Letters 212-214 2002/02
-
Indole synthesis by radical cyclization of o-alkenylphenyl isocyanides and its application to the total synthesis of natural products
Tokuyama, H., Fukuyama, T.
Chemical Record 2 (1) 2002
DOI：
10.1002/tcr.10008
-
Indole synthesis by radical cyclization of o-alkenylphenyl isocyanides and its application to the total synthesis of natural products
Tokuyama, H., Fukuyama, T.
Chemical Record 2 (1) 2002
DOI：
10.1002/tcr.10008
-
One-pot Claisen rearrangement with N-butyl vinyl ether
Peer-reviewed
H Tokuyama, T Makido, T Ueda, T Fukuyama
SYNTHETIC COMMUNICATIONS 32 (6) 869-873 2002
DOI：
10.1081/SCC-120002696
ISSN：
0039-7911
-
Facile construction of N-hydroxybenzazocine: Enantioselective total synthesis of FR900482
Peer-reviewed
M Suzuki, M Kambe, H Tokuyama, T Fukuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 41 (24) 4686-4688 2002
DOI：
10.1002/anie.200290016
ISSN：
1433-7851
-
28 Total Synthesis of (+)-Vinblastine
Yokoshima Satoshi, Ueda Toshihiro, Kobayashi Satoshi, Sato Ayato, Kuboyama Takeshi, Tokuyama Hedetoshi, Fukuyama Tohru
Symposium on the Chemistry of Natural Products, symposium papers (43) 163-168 2001/09/01
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.43.0_163
-
A novel protocol for construction of indolylmethyl group at aldehydes or ketones
Peer-reviewed
H Tokuyama, M Watanabe, YI Hayashi, T Kurokawa, G Peng, T Fukuyama
SYNLETT (9) 1403-1406 2001/09
ISSN：
0936-5214
-
Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues
Peer-reviewed
M Kambe, E Arai, M Suzuki, H Tokuyama, T Fukuyama
ORGANIC LETTERS 3 (16) 2575-2578 2001/08
DOI：
10.1021/ol016243t
ISSN：
1523-7060
-
ラジカル環化反応を用いたインドール合成法の新展開とインドールアルカロイド合成への応用
徳山 英利
有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 59 (5) 488-489 2001/05/01
Publisher:
The Society of Synthetic Organic Chemistry, Japan
DOI：
10.5059/yukigoseikyokaishi.59.488
ISSN：
0037-9980
-
反応機構ちからだめし No.2
Peer-reviewed
徳山 英利, 菅 敏幸
ファルマシア 37 (2) 143-143 2001
Publisher:
公益社団法人 日本薬学会
DOI：
10.14894/faruawpsj.37.2_143
ISSN：
0014-8601
-
A practical route to quinolines from anilines
Peer-reviewed
H Tokuyama, M Sato, T Ueda, T Fukuyama
HETEROCYCLES 54 (1) 105-108 2001/01
ISSN：
0385-5414
-
A novel transformation of primary amines to N-monoalkylhydroxylamines
Peer-reviewed
Tokuyama, H., Kuboyama, T., Amano, A., Yamashita, T., Fukuyama, T.
Synthesis (9) 1299-1304 2000/10
DOI：
10.1055/s-2000-6428
-
Synthesis of 2,3-disubstituted indoles by palladium-mediated coupling of 2-iodoindoles
Peer-reviewed
H Tokuyama, Y Kaburagi, XQ Chen, T Fukuyama
SYNTHESIS-STUTTGART (3) 429-434 2000/03
DOI：
10.1055/s-2000-6354
ISSN：
0039-7881
-
Enantioselective total synthesis of (+)-gelsemine: Determination of its absolute configuration
Peer-reviewed
S Yokoshima, H Tokuyama, T Fukuyama
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 39 (22) 4073-4075 2000
DOI：
10.1002/1521-3773(20001117)39:22<4073::AID-ANIE4073>3.0.CO;2-V
ISSN：
1433-7851
-
11 A Novel Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization of 2-Alkenylthioanilides and Its Applications
Tokuyama Hidetoshi, Yamashita Tohru, Reding Matthew T., Kaburagi Yosuke, Fukuyama Tohru
Symposium on the Chemistry of Natural Products, symposium papers (41) 61-66 1999/09/01
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.41.0_61
-
Radical cyclization of 2-alkenylthioanilides: A novel synthesis of 2,3-disubstituted indoles
Peer-reviewed
H Tokuyama, T Yamashita, MT Reding, Y Kaburagi, T Fukuyama
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 121 (15) 3791-3792 1999/04
ISSN：
0002-7863
-
Cyclopropenone-containing cysteine proteinase inhibitors. Synthesis and enzyme inhibitory activities
Peer-reviewed
Ryoichi Ando, Toshiro Sakaki, Yasuhiro Morinaka, Chizuko Takahashi, Yoshikuni Tamao, Narihiko Yoshii, Sota Katayama, Ken-Ichi Saito, Hidetoshi Tokuyama, Masahiko Isaka, Eiichi Nakamura
Bioorganic and Medicinal Chemistry 7 (4) 571-579 1999/04
DOI：
10.1016/S0968-0896(99)00007-3
ISSN：
0968-0896
-
Facile palladium-mediated conversion of ethanethiol esters to aldehydes and ketones
Peer-reviewed
H Tokuyama, S Yokoshima, T Yamashita, SC Lin, LP Li, T Fukuyama
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 9 (4) 381-387 1998/07
ISSN：
0103-5053
-
A novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagents
Peer-reviewed
H Tokuyama, S Yokoshima, T Yamashita, T Fukuyama
TETRAHEDRON LETTERS 39 (20) 3189-3192 1998/05
DOI：
10.1016/S0040-4039(98)00456-0
ISSN：
0040-4039
-
2-(2-Aminophenyl)-acetaldehyde dimethyl acetal: A novel reagent for the protection of carboxylic acids.
Peer-reviewed
E Arai, H Tokuyama, MS Linsell, T Fukuyama
TETRAHEDRON LETTERS 39 (1-2) 71-74 1998/01
DOI：
10.1016/S0040-4039(97)10491-9
ISSN：
0040-4039
-
Synthetic and computational studies on symmetry-defined double cycloaddition of a new tris-annulating reagent to C-60
Peer-reviewed
H Isobe, H Tokuyama, M Sawamura, E Nakamura
JOURNAL OF ORGANIC CHEMISTRY 62 (15) 5034-5041 1997/07
DOI：
10.1021/jo970685u
ISSN：
0022-3263
-
Regio- and diastereocontrolled double cycloaddition to C-60 with new tris-annulating reagents
Peer-reviewed
H Isobe, H Tokuyama, M Sawamura, E Nakamura
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 212 57-ORGN 1996/08
ISSN：
0065-7727
-
Biological activity of water-soluble fullerenes. Structural dependence of DNA cleavage, cytotoxicity, and enzyme inhibitory activities including HIV-protease inhibition
Peer-reviewed
E Nakamura, H Tokuyama, S Yamago, T Shiraki, Y Sugiura
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 69 (8) 2143-2151 1996/08
DOI：
10.1246/bcsj.69.2143
ISSN：
0009-2673
eISSN：
1348-0634
-
Photocytotoxicity of water-soluble fullerene derivatives
Peer-reviewed
K Irie, Y Nakamura, H Ohigashi, H Tokuyama, S Yamago, E Nakamura
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 60 (8) 1359-1361 1996/08
DOI：
10.1271/bbb.60.1359
ISSN：
0916-8451
eISSN：
1347-6947
-
Regio- and diastereo-controlled double cycloaddition to [60]fullerene: One-step synthesis of Cs and C-2 chiral organofullerenes with new tris-annulating reagents
Peer-reviewed
E Nakamura, H Isobe, H Tokuyama, M Sawamura
CHEMICAL COMMUNICATIONS (15) 1747-1748 1996/08
DOI：
10.1039/cc9960001747
ISSN：
1359-7345
-
Nitrene additions to [60]fullerene do not generate [6,5]aziridines
Peer-reviewed
AB Smith, H Tokuyama
TETRAHEDRON 52 (14) 5257-5262 1996/04
DOI：
10.1016/0040-4020(96)00129-9
ISSN：
0040-4020
-
Structure of fullerene anchored by five-membered-ring
Peer-reviewed
H Amano, H Uekusa, Y Ohashi, H Tokuyama, E Nakamura
MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS 276 291-294 1996
ISSN：
1058-725X
-
SYNTHESIS OF OXO-BRIDGED AND METHYLENE-BRIDGED C-60 DIMERS, THE FIRST WELL-CHARACTERIZED SPECIES CONTAINING FULLERENE-FULLERENE BONDS
Peer-reviewed
AB SMITH, H TOKUYAMA, RM STRONGIN, GT FURST, WJ ROMANOW, BT CHAIT, UA MIRZA, HALLER, I
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 117 (36) 9359-9360 1995/09
DOI：
10.1021/ja00141a031
ISSN：
0002-7863
-
IN-VIVO BIOLOGICAL BEHAVIOR OF A WATER-MISCIBLE FULLERENE - C-14 LABELING, ABSORPTION, DISTRIBUTION, EXCRETION AND ACUTE TOXICITY
Peer-reviewed
S YAMAGO, H TOKUYAMA, E NAKAMURA, K KIKUCHI, S KANANISHI, K SUEKI, H NAKAHARA, S ENOMOTO, F AMBE
CHEMISTRY & BIOLOGY 2 (6) 385-389 1995/06
ISSN：
1074-5521
-
Fullerene–Oligonucleotide Conjugates: Photoinduced Sequence‐Specific DNA Cleavage
Peer-reviewed
Alexandre S. Boutorine, Masashi Takasugi, Claude Hélène, Hidetoshi Tokuyama, Hiroyuki Isobe, Eiichi Nakamura
Angewandte Chemie International Edition in English 33 (23-24) 2462-2465 1995/01/03
DOI：
10.1002/anie.199424621
ISSN：
1521-3773 0570-0833
-
METHANOFULLERENES AND PROPANOFULLERENES BY [1+2] AND [3+2] CYCLOADDITIONS OF VINYLCARBENE SPECIES
Peer-reviewed
H TOKUYAMA, H ISOBE, E NAKAMURA
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 68 (3) 935-941 1995
DOI：
10.1246/bcsj.68.935
ISSN：
0009-2673
eISSN：
1348-0634
-
SYNTHESIS OF CYCLOPROPENONE-CONTAINING AMINO-ACID MIMIC - ADDITION OF CYCLOPROPENYL CERIUM REAGENT TO ALPHA-AMINO ALDEHYDES
Peer-reviewed
H TOKUYAMA, M ISAKA, E NAKAMURA
SYNTHETIC COMMUNICATIONS 25 (13) 2005-2012 1995
DOI：
10.1080/00397919508015878
ISSN：
0039-7911
-
PHOTOADDITION OF SILYL KETENE ACETAL TO [60]FULLERENE - SYNTHESIS OF ALPHA-FULLERENE-SUBSTITUTED CARBOXYLIC ESTERS
Peer-reviewed
H TOKUYAMA, H ISOBE, E NAKAMURA
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS (24) 2753-2754 1994/12
DOI：
10.1039/c39940002753
ISSN：
0022-4936
-
SYNTHETIC CHEMISTRY WITH FULLERENES - PHOTOOXYGENATION OF OLEFINS
Peer-reviewed
H TOKUYAMA, E NAKAMURA
JOURNAL OF ORGANIC CHEMISTRY 59 (5) 1135-1138 1994/03
DOI：
10.1021/jo00084a036
ISSN：
0022-3263
-
FULLERENE-OLIGONUCLEOTIDE CONJUGATES - PHOTOINDUCED SEQUENCE-SPECIFIC DNA CLEAVAGE
Peer-reviewed
AS BOUTORINE, H TOKUYAMA, M TAKASUGI, H ISOBE, E NAKAMURA, C HELENE
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 33 (23-24) 2462-2465 1994/01
ISSN：
1433-7851
-
SYNTHESIS OF ORGANIC DERIVATIVES OF FULLERENES
Peer-reviewed
S YAMAGO, H TOKUYAMA, E NAKAMURA, M PRATO, F WUDL
ADVANCED MATERIALS '93, I - A & B 14 (A & B) 1169-1172 1994
-
[1+2] AND [3+2] CYCLOADDITION REACTIONS OF VINYLCARBENES WITH C-60
Peer-reviewed
H TOKUYAMA, M NAKAMURA, E NAKAMURA
TETRAHEDRON LETTERS 34 (46) 7429-7432 1993/11
DOI：
10.1016/S0040-4039(00)60144-2
ISSN：
0040-4039
-
22 [3+2] Cycloaddition Approach for the Synthesis of Biological Active Compounds
Yamago Shigeru, Tokuyama Hidetoshi, Yanagawa Masao, Nakamura Eiichi, Shiraki Takashi, Sugiura Yukio
Symposium on the Chemistry of Natural Products, symposium papers (35) 167-173 1993/09/10
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.35.0_167
-
REGIOSELECTIVE GENERATION AND STEREOSELECTIVE [1+2] CYCLOADDITION OF SUBSTITUTED VINYLCARBENES
Peer-reviewed
H TOKUYAMA, T YAMADA, E NAKAMURA
SYNLETT (8) 589-591 1993/08
ISSN：
0936-5214
-
PHOTOINDUCED BIOCHEMICAL-ACTIVITY OF FULLERENE CARBOXYLIC-ACID
Peer-reviewed
H TOKUYAMA, S YAMAGO, E NAKAMURA, T SHIRAKI, Y SUGIURA
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 115 (17) 7918-7919 1993/08
DOI：
10.1021/ja00070a064
ISSN：
0002-7863
-
CHEMICAL DERIVATIZATION OF ORGANOFULLERENES THROUGH OXIDATION, REDUCTION, AND C-O AND C-C BOND-FORMING REACTIONS
Peer-reviewed
S YAMAGO, H TOKUYAMA, E NAKAMURA, M PRATO, F WUDL
JOURNAL OF ORGANIC CHEMISTRY 58 (18) 4796-4798 1993/08
DOI：
10.1021/jo00070a009
ISSN：
0022-3263
-
A NEW CLASS OF PROTEINASE-INHIBITOR - CYCLOPROPENONE-CONTAINING INHIBITOR OF PAPAIN
Peer-reviewed
R ANDO, Y MORINAKA, H TOKUYAMA, M ISAKA, E NAKAMURA
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 115 (3) 1174-1175 1993/02
DOI：
10.1021/ja00056a067
ISSN：
0002-7863
-
THERMAL-REACTIONS OF SUBSTITUTED CYCLOPROPENONE ACETALS - REGIOCHEMISTRY AND STEREOCHEMISTRY OF VINYLCARBENE FORMATION AND LOW-TEMPERATURE [3+2] CYCLOADDITION
Peer-reviewed
H TOKUYAMA, M ISAKA, E NAKAMURA
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 114 (14) 5523-5530 1992/07
DOI：
10.1021/ja00040a006
ISSN：
0002-7863
-
SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF CYCLOPROPENONE ANTIBIOTIC PENITRICIN AND CONGENERS
Peer-reviewed
H TOKUYAMA, M ISAKA, E NAKAMURA, R ANDO, Y MORINAKA
JOURNAL OF ANTIBIOTICS 45 (7) 1148-1154 1992/07
DOI：
10.7164/antibiotics.45.1148
ISSN：
0021-8820
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61(P1-9) SYNTHESIS OF THE CYCLOPROPENONE ANTIBIOTIC PENITRICIN AND ITS CONGENERS
Isaka Masahiko, Tokuyama Hidetoshi, Yamago Shigeru, Ejiri Satoshi, Miyachi Yoshimitsu, Nakamura Eiichi
Symposium on the Chemistry of Natural Products, symposium papers (31) 467-473 1989/09/17
Publisher:
Symposium on the chemistry of natural products
DOI：
10.24496/tennenyuki.31.0_467
https://orcid.org/0000-0002-6519-7727