Details of the Researcher

PHOTO

Shimpei Kawamoto
Section
Healthspan Research Center
Job title
Professor
e-Rad No.
40612081

Awards 13

  1. 2025 年度長瀬研究振興賞

    2025/04　公益財団法人長瀬科学技術振興財団　腸内細菌による腸管老化促進機構の解明とその制御法の開発

  2. 第23回杉田玄白賞 奨励賞

    2024/12　小浜市　IgAを介した宿主と腸内細菌叢の相互作用が健康及び老化に及ぼす影響の解明

  3. 令和5年度腸内細菌学会研究奨励賞

    2024/06　公益財団法人腸内細菌学会

  4. 第64回学術奨励賞

    2024/04　公益財団法人UBE学術振興財団

  5. 令和5年度大阪大学賞（若手教員部門）

    2023/11　大阪大学

  6. 第18回日本免疫学会研究奨励賞

    2023/10　日本免疫学会

  7. Best Oral Presentation Award

    2023/10　The 18th International Symposium of the Institute Network for Biomedical Sciences

  8. 微研研究業績発表会最優秀学術賞

    2023/01　大阪大学微生物病研究所

  9. 文部科学大臣表彰(若手科学者賞）

    2020/04　文部科学省　免疫系を介した宿主と腸内細菌叢の相互作用に関する研究

  10. 平成26年度理化学研究所技術奨励賞

    2015/03　独立行政法人理化学研究所　Foxp3+ T cells regulate immunoglobulin A selection and facilitate diversification of bacterial species responsible for immune homeostasis

  11. The Excellent Paper Award 2012

    2013/03　独立行政法人理化学研究所免疫・アレルギー科学総合研究センター　The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

  12. 平成24年度理化学研究所研究奨励賞

    2013/03　独立行政法人理化学研究所　The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

  13. 2012年度内藤記念科学振興財団研究奨励賞

    2012/10　公益財団法人内藤記念科学振興財団　抑制性受容体PD-1は免疫グロブリンAの選択を制御することにより腸内細菌制御に関与している

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Papers 26

  1. Limitations of the p16-3MR mouse model for detecting and eliminating senescent cells

    Nozomi Hori, Shimpei Kawamoto, Ken Uemura, Yumi Kinugasa-Katayama, Yumiko Okumura, Kentaro Tanaka, Jeong Hoon Park, Masahiro Wakita, Daisuke Motooka, Naoko Ohtani, Eiji Hara

    EMBO Reports　2026/05/28

    DOI： 10.1038/s44319-026-00802-8 　

  2. Senescence-like cells recruit γδ T cells to drive prolonged hyposmia after SARS-CoV-2 infection in mice

    Shunya Tsuji, Sosuke Nakano, Koyu Ito, Shohei Minami, Ken Uemura, Yusuke Konishi, Masahiro Wakita, Yumiko Okumura, Shimpei Kawamoto, Akari Matsuki, Shinji Nakaoka, Chikako Ono, Hiroo Takahashi, Itsuki Anzai, Tokiko Watanabe, Akiyoshi Uezumi, Yoshiharu Matsuura, Takeshi Kobayashi, Toru Okamoto, Akio Tsuboi, Masataka Asagiri, Eiji Hara

    EMBO Reports　2026/04/10

    DOI： 10.1038/s44319-026-00769-6 　

  3. Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor

    Shimpei Kawamoto, Haruki Horiguchi, Daisuke Torigoe, Masahiro Wakita, Koyu Ito, Sho Sugawara, Xiangyu Zhou, Takumi Mikawa, Jeong Hoon Park, Birte Kristin Jung, Yumiko Okumura, Hideka Miyagawa, Mikako Maruya, Nozomi Hori, Ken Uemura, Masataka Sugimoto, Michiyuki Matsuda, Naoki Mochizuki, Hiroshi Kondoh, Akiko Takahashi, Yuichi Oike, Eiji Hara

    EMBO Reports　2026/04/03

    DOI： 10.1038/s44319-026-00740-5 　

  4. B cell senescence promotes age-related changes in oral microbiota. International-journal Peer-reviewed

    Hiroya Mizuno, Shimpei Kawamoto, Ken Uemura, Jeong Hoon Park, Nozomi Hori, Yumiko Okumura, Yusuke Konishi, Eiji Hara

    Aging cell　e14304　2024/08/09

    DOI： 10.1111/acel.14304 　

    More details Close

    In recent years, there has been increasing attention towards understanding the relationship between age-related alterations in the oral microbiota and age-associated diseases, with reports emphasizing the significance of maintaining a balanced oral microbiota for host health. However, the precise mechanisms underlying age-related changes in the oral microbiota remain elusive. We recently reported that cellular senescence of ileal germinal center (GC) B cells, triggered by the persistent presence of commensal bacteria, results in diminished IgA production with aging and subsequent alterations in the gut microbiota. Consequently, we hypothesize that a similar phenomenon may occur in the oral cavity, potentially contributing to age-related changes in the oral microbiota. Examination of p16-luc mice, wherein the expression of the senescent cell marker p16INK4a can be visualized, raised under specific pathogen-free (SPF) or germ-free (GF) conditions, indicated that, unlike ileal GC B cells, the accumulation of senescent cells in GC B cells of cervical lymph nodes increases with age regardless of the presence of commensal bacteria. Furthermore, longitudinal studies utilizing the same individual mice throughout their lifespan revealed concurrent age-related alterations in the composition of the oral microbiota and a decline in salivary IgA secretion. Further investigation involving Rag1-/- mice transplanted with B cells from wild-type or p16INK4a and p21Waf1/Cip1 -double knockout mice unveiled that B cell senescence leads to reduced IgA secretion and alteration of the oral microbiota. These findings advance our understanding of the mechanism of age-associated changes in the oral microbiota and open up possibilities of their control.

  5. Crosstalk between gut microbiota and cellular senescence: a vicious cycle leading to aging gut. International-journal Peer-reviewed

    Shimpei Kawamoto, Eiji Hara

    Trends in cell biology　2024/01/13

    DOI： 10.1016/j.tcb.2023.12.004 　

    ISSN： 0962-8924

    eISSN： 1879-3088

  6. Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice. International-journal Peer-reviewed

    Tsutomu Endo, Kiyonori Kobayashi, Takafumi Matsumura, Chihiro Emori, Manabu Ozawa, Shimpei Kawamoto, Daisuke Okuzaki, Keisuke Shimada, Haruhiko Miyata, Kentaro Shimada, Mayo Kodani, Yu Ishikawa-Yamauchi, Daisuke Motooka, Eiji Hara, Masahito Ikawa

    Communications biology　7　(1)　16-16　2024/01/04

    DOI： 10.1038/s42003-023-05685-2 　

    eISSN： 2399-3642

  7. Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype. International-journal Peer-reviewed

    Tatsuyuki Matsudaira, Sosuke Nakano, Yusuke Konishi, Shimpei Kawamoto, Ken Uemura, Tamae Kondo, Koki Sakurai, Takaaki Ozawa, Takatoshi Hikida, Okiru Komine, Koji Yamanaka, Yuki Fujita, Toshihide Yamashita, Tomonori Matsumoto, Eiji Hara

    Communications biology　6　(1)　665-665　2023/06/23

    DOI： 10.1038/s42003-023-05027-2 　

    eISSN： 2399-3642

  8. Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota. International-journal Peer-reviewed

    Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Lena Takayasu, Yusuke Konishi, Kazutaka Katoh, Tomonori Matsumoto, Masae Suzuki, Yusuke Sakai, Tatsuyuki Matsudaira, Takahiro Adachi, Naoko Ohtani, Daron M Standley, Wataru Suda, Shinji Fukuda, Eiji Hara

    Nature cell biology　25　(6)　865-876　2023/06/01

    DOI： 10.1038/s41556-023-01145-5 　

    ISSN： 1465-7392

    eISSN： 1476-4679

  9. Sesamin Metabolites Suppress the Induction of Cellular Senescence. International-journal Peer-reviewed

    Chie Araki, Daisuke Takemoto, Yoshinori Kitagawa, Norifumi Tateishi, Tomohiro Rogi, Takayuki Izumo, Shimpei Kawamoto, Hiroshi Shibata, Eiji Hara, Masaaki Nakai

    Nutrients　15　(7)　2023/03/27

    DOI： 10.3390/nu15071627 　

    eISSN： 2072-6643

  10. The 6th international cell senescence association conference Peer-reviewed

    Shimpei Kawamoto, Tomonori Matsumoto, Masaki Takasugi, Eiji Hara

    Genes to Cells　27　(8)　517-525　2022/08/01

    DOI： 10.1111/gtc.12970 　

    ISSN： 1356-9597

    eISSN： 1365-2443

  11. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response Peer-reviewed

    Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo, Miwa Sasai, Shiho Torii, Chikako Ono, Shintaro Shichinohe, Shintaro Sato, Masahiro Wakita, Shintaro Okumura, Sosuke Nakano, Tatsuyuki Matsudaira, Tomonori Matsumoto, Shimpei Kawamoto, Masahiro Yamamoto, Tokiko Watanabe, Yoshiharu Matsuura, Kazuo Takayama, Takeshi Kobayashi, Toru Okamoto, Eiji Hara

    Nature Aging　2　(2)　115-124　2022/02/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s43587-022-00170-7 　

    eISSN： 2662-8465

  12. Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion. International-journal Peer-reviewed

    Shintaro Okumura, Yusuke Konishi, Megumi Narukawa, Yuki Sugiura, Shin Yoshimoto, Yuriko Arai, Shintaro Sato, Yasuo Yoshida, Shunya Tsuji, Ken Uemura, Masahiro Wakita, Tatsuyuki Matsudaira, Tomonori Matsumoto, Shimpei Kawamoto, Akiko Takahashi, Yoshiro Itatani, Hiroaki Miki, Manabu Takamatsu, Kazutaka Obama, Kengo Takeuchi, Makoto Suematsu, Naoko Ohtani, Yosuke Fukunaga, Masashi Ueno, Yoshiharu Sakai, Satoshi Nagayama, Eiji Hara

    Nature communications　12　(1)　5674-5674　2021/09/28

    DOI： 10.1038/s41467-021-25965-x 　

    eISSN： 2041-1723

  13. Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis Peer-reviewed

    Yamato Tanabe, Shimpei Kawamoto, Tomoiku Takaku, Soji Morishita, Atsushi Hirao, Norio Komatsu, Eiji Hara, Naofumi Mukaida, Tomohisa Baba

    Blood Advances　4　(24)　6175-6188　2020/12/22

    DOI： 10.1182/bloodadvances.2020003117 　

    ISSN： 2473-9529

    eISSN： 2473-9537

  14. A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells Peer-reviewed

    Masahiro Wakita, Akiko Takahashi, Osamu Sano, Tze Mun Loo, Yoshinori Imai, Megumi Narukawa, Hidehisa Iwata, Tatsuyuki Matsudaira, Shimpei Kawamoto, Naoko Ohtani, Tamotsu Yoshimori, Eiji Hara

    Nature Communications　11　(1)　2020/12/01

    DOI： 10.1038/s41467-020-15719-6 　

    eISSN： 2041-1723

  15. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells Peer-reviewed

    Akiko Takahashi, Tze Mun Loo, Ryo Okada, Fumitaka Kamachi, Yoshihiro Watanabe, Masahiro Wakita, Sugiko Watanabe, Shimpei Kawamoto, Kenichi Miyata, Glen N. Barber, Naoko Ohtani, Eiji Hara

    Nature Communications　9　(1)　2018/12/01

    DOI： 10.1038/s41467-018-03555-8 　

    eISSN： 2041-1723

  16. The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells

    Ajithkumar Vasanthakumar, Kazuyo Moro, Annie Xin, Yang Liao, Renee Gloury, Shimpei Kawamoto, Sidonia Fagarasan, Lisa A. Mielke, Shoukat Afshar-Sterle, Seth L. Masters, Susumu Nakae, Hirohisa Saito, John M. Wentworth, Peng Li, Wei Liao, Warren J. Leonard, Gordon K. Smyth, Wei Shi, Stephen L. Nutt, Shigeo Koyasu, Axel Kallies

    Nature Immunology　16　(3)　276-285　2015/02/17

    DOI： 10.1038/ni.3085 　

    ISSN： 1529-2908

    eISSN： 1529-2916

  17. Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

    Shimpei Kawamoto, Mikako Maruya, Lucia M. Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, Sidonia Fagarasan

    Immunity　41　(1)　152-165　2014/07/17

    DOI： 10.1016/j.immuni.2014.05.016 　

    ISSN： 1074-7613

    eISSN： 1097-4180

  18. Impaired selection of IgA and intestinal dysbiosis associated with PD-1-deficiency

    Mikako Maruya, Shimpei Kawamoto, Lucia M. Kato, Sidonia Fagarasan

    Gut Microbes　4　(2)　165-171　2013/03

    DOI： 10.4161/gmic.23595 　

    ISSN： 1949-0976

    eISSN： 1949-0984

  19. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut

    Shimpei Kawamoto, Thinh H. Tran, Mikako Maruya, Keiichiro Suzuki, Yasuko Doi, Yumi Tsutsui, Lucia M. Kato, Sidonia Fagarasan

    Science　336　(6080)　485-489　2012/04

    DOI： 10.1126/science.1217718 　

    ISSN： 0036-8075

    eISSN： 1095-9203

  20. Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease

    Jeffrey VanValkenburgh, Diana I. Albu, Chandra Bapanpally, Sarah Casanova, Danielle Califano, David M. Jones, Leszek Ignatowicz, Shimpei Kawamoto, Sidonia Fagarasan, Nancy A. Jenkins, Neal G. Copeland, Pentao Liu, Dorina Avram

    Journal of Experimental Medicine　208　(10)　2069-2081　2011/09/26

    DOI： 10.1084/jem.20102683 　

    ISSN： 0022-1007

    eISSN： 1540-9538

  21. Foxp3+ follicular regulatory T cells control the germinal center response

    Michelle A. Linterman, Wim Pierson, Sau K. Lee, Axel Kallies, Shimpei Kawamoto, Tim F. Rayner, Monika Srivastava, Devina P. Divekar, Laura Beaton, Jennifer J. Hogan, Sidonia Fagarasan, Adrian Liston, Kenneth G.C. Smith, Carola G. Vinuesa

    Nature Medicine　17　(8)　975-982　2011/08

    DOI： 10.1038/nm.2425 　

    ISSN： 1078-8956

    eISSN： 1546-170X

  22. B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

    Sau K. Lee, Robert J. Rigby, Dimitra Zotos, Louis M. Tsai, Shimpei Kawamoto, Jennifer L. Marshall, Roybel R. Ramiscal, Tyani D. Chan, Dominique Gatto, Robert Brink, Di Yu, Sidonia Fagarasan, David M. Tarlinton, Adam F. Cunningham, Carola G. Vinuesa

    Journal of Experimental Medicine　208　(7)　1377-1388　2011/07/04

    DOI： 10.1084/jem.20102065 　

    ISSN： 0022-1007

    eISSN： 1540-9538

  23. Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

    Il Mi Okazaki, Katsuya Okawa, Maki Kobayashi, Kiyotsugu Yoshikawa, Shimpei Kawamoto, Hitoshi Nagaoka, Reiko Shinkura, Yoko Kitawaki, Hisaaki Taniguchi, Tohru Natsume, Shun Ichiro Iemura, Tasuku Honjo

    Proceedings of the National Academy of Sciences of the United States of America　108　(19)　7920-7925　2011/05/10

    DOI： 10.1073/pnas.1104423108 　

    ISSN： 0027-8424

    eISSN： 1091-6490

  24. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut

    Keiichiro Suzuki, Mikako Maruya, Shimpei Kawamoto, Katarzyna Sitnik, Hiroshi Kitamura, William W. Agace, Sidonia Fagarasan

    Immunity　33　(1)　71-83　2010/07

    DOI： 10.1016/j.immuni.2010.07.003 　

    ISSN： 1074-7613

  25. GALT. Organization and dynamics leading to IgA synthesis

    Keiichiro Suzuki, Shimpei Kawamoto, Mikako Maruya, Sidonia Fagarasan

    Advances in Immunology　107　(C)　153-185　2010

    DOI： 10.1016/B978-0-12-381300-8.00006-X 　

    ISSN： 0065-2776

    eISSN： 1557-8445

  26. Preferential generation of follicular B helper T cells from Foxp3 + T cells in gut Peyer's patches

    Masayuki Tsuji, Noriko Komatsu, Shimpei Kawamoto, Keiichiro Suzuki, Osami Kanagawa, Tasuku Honjo, Shohei Hori, Sidonia Fagarasan

    Science　323　(5920)　1488-1492　2009/03/13

    DOI： 10.1126/science.1169152 　

    ISSN： 0036-8075

    eISSN： 1095-9203

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Misc. 10

  1. The Non- Senolytic Effects of asatinib and Quercetin (D plus Q) on Cellular Senescence

    Koyu Ito, Masahiro Wakita, Birte Jung, Shimpei Kawamoto, Yuuki Ohara, Yumiko Okumura, Sosuke Nakano, Yasutoshi Agata, Shinya Toyokuni, Eiji Hara

    CANCER SCIENCE　117　115-115　2026/01

    ISSN： 1347-9032

    eISSN： 1349-7006

  2. Effects of HPV-derived E6/E7 genes on the cell cycle arrest after anti-cancer drug treatment

    Kazuki Hayashi, Tomonori Matsumoto, Ken Uemura, Masahiro Wakita, Shimpei Kawamoto, Takahito Fukusumi, Hidenori Inohara, Eiji Hara

    CANCER SCIENCE　114　525-525　2023/02

    ISSN： 1347-9032

    eISSN： 1349-7006

  3. Obesity associated alternation of the skin microbiota promotes skin carcinogenesis in mice

    Ken Uemura, Shimpei Kawamoto, Masahiro Wakita, Eiji Hara

    CANCER SCIENCE　113　1081-1081　2022/02

    ISSN： 1347-9032

    eISSN： 1349-7006

  4. Identification and characterization of skin bacteria involved in skin carcinogenesis in mice

    Ken Uemura, Shimpei Kawamoto, Masahiro Wakita, Eiji Hara

    CANCER SCIENCE　112　257-257　2021/02

    ISSN： 1347-9032

    eISSN： 1349-7006

  5. The regulation of gut microbiota by immunoglobulin a and foxp3 t cells

    Shimpei Kawamoto

    Japanese Journal of Allergology　67　(2)　114-116　2018

    DOI： 10.15036/arerugi.67.114 　

    ISSN： 0021-4884

    eISSN： 1347-7935

  6. Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases

    Sugiko Watanabe, Shimpei Kawamoto, Naoko Ohtani, Eiji Hara

    Cancer Science　108　(4)　563-569　2017/04

    DOI： 10.1111/cas.13184 　

    ISSN： 1347-9032

    eISSN： 1349-7006

  7. The role of the adaptive immune system in regulation of gut microbiota

    Lucia M. Kato, Shimpei Kawamoto, Mikako Maruya, Sidonia Fagarasan

    Immunological Reviews　260　(1)　67-75　2014/07

    DOI： 10.1111/imr.12185 　

    ISSN： 0105-2896

    eISSN： 1600-065X

  8. Gut T<inf>FH</inf> and IgA: Key players for regulation of bacterial communities and immune homeostasis

    Lucia M. Kato, Shimpei Kawamoto, Mikako Maruya, Sidonia Fagarasan

    Immunology and Cell Biology　92　(1)　49-56　2014/01

    DOI： 10.1038/icb.2013.54 　

    ISSN： 0818-9641

    eISSN： 1440-1711

  9. Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity

    Keiichiro Suzuki, Mikako Maruya, Shimpei Kawamoto, Sidonia Fagarasan

    Immunological Reviews　237　(1)　180-190　2010/09

    DOI： 10.1111/j.1600-065X.2010.00941.x 　

    ISSN： 0105-2896

    eISSN： 1600-065X

  10. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis

    Sidonia Fagarasan, Shimpei Kawamoto, Osami Kanagawa, Keiichiro Suzuki

    Annual Review of Immunology　28　243-273　2010/04

    DOI： 10.1146/annurev-immunol-030409-101314 　

    ISSN： 0732-0582

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Presentations 18

  1. Age-related disruption of the crosstalk between host and gut microbiota through B-cell senescence Invited

    河本 新平

    International Symposium on Cancer・Aging Biology and Bioinformatics　2025/02

  2. 加齢に伴うIgAを介した宿主と腸内細菌叢のクロストーク Invited

    河本 新平

    第58回日本無菌生物ノートバイオロジー学会総会　2025/01

  3. The crosstalk between gut microbiota and cellular senescence Invited

    河本 新平

    第47回日本分子生物学会年会　2024/11

  4. Age-related disruption of the cross-talk between host and gut microbiota through B-cell senescence Invited

    河本 新平

    第97回日本生化学会大会　2024/11

  5. 腸内細菌叢と細胞老化のクロストーク ?腸の老化につながる悪循環? Invited

    河本 新平

    In vivoイメージングフォーラム2024 第17回IVISユーザーの会　2024/10

  6. 加齢に伴うIgAを介した腸内細菌叢とB細胞のクロストークの破綻 Invited

    河本 新平

    第52回日本臨床免疫学会総会　2024/10

  7. 腸内細菌による細胞老化を介した腸管老化の促進機構 Invited

    河本 新平

    第157回日本獣医学会学術集会・日本実験動物医学会シンポジウム　2024/09

  8. 免疫グロブリンAを介した宿主と腸内細菌叢の相互作用の解明 Invited

    河本 新平

    第3回日本医学会連合Rising Starリトリート　2024/06

  9. 免疫グロブリンAを介した宿主と腸内細菌叢の相互作用の解明 Invited

    河本 新平

    第28回腸内細菌学会　2024/06

  10. Identification and characterization of skin bacteria involved in obesity-induced skin tumorigenesis in mice

    河本 新平

    第51回内藤コンファレンス　2024/06

  11. Bacterial induction of B-cell senescence promotes age-related changes in gut microbiota

    河本 新平

    第51回内藤コンファレンス　2024/06

  12. Bacterial induction of B-cell senescence promotes age-related changes in gut microbiota International-presentation Invited

    河本 新平

    A3 Foresight Meeting　2024/05

  13. 細胞老化の誘導に関わる腸内細菌の特定と個体老化に与える影響の解明 Invited

    河本 新平

    文部科学省共同利用・共同研究システム形成事業 学際領域展開ハブ形成プログラムキックオフシンポジウム　2024/02

  14. Bacterial induction of B-cell senescence promotes age-related changes in gut microbiota

    Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Kazutaka Katoh, Takahiro Adachi, Naoko Ohtani, Daron M. Standley, Wataru Suda, Shinji Fukuda, Eiji Hara

    第52回日本免疫学会学術集会　2024/01

  15. 免疫グロブリンAを介した宿主と腸内細菌叢のクロストーク —生体恒常性維持における重要性とその破綻が老化に及ぼす影響— Invited

    河本 新平

    関西共創の場 第28回若手人材セミナー　2023/12

  16. 加齢に伴う免疫グロブリンAを介した宿主と腸内細菌叢の相互作用の破綻 Invited

    河本 新平, 原 英二

    第19回 日本食品免疫学会学術大会　2023/11

  17. Bacterial induction of B-cell senescence promotes age-related changes in gut microbiota Invited

    Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Lena Takayasu, Kazutaka Katoh, Tomonori Matsumoto, Yusuke Sakai, Takahiro Adachi, Naoko Ohtani, Daron M. Standley, Wataru Suda, Shinji Fukuda, Eiji Hara

    18th International Symposium of The Institute Network　2023/10

  18. Bacterial induction of B-cell senescence promotes age-related changes in gut microbiota

    8th International Cell Senescence Association (ICSA) Conference　2023/10

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Research Projects 6

  1. 常在細菌のストレスに起因する老化メカニズムの解明

    河本 新平

    Offer Organization: 科学技術振興機構

    Category: 戦略的な研究開発の推進/創発的研究支援事業

    2024 - 2031

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    老化は様々な組織の機能低下を引き起こし生活の質の低下や加齢性疾患発症の原因となるため、健康寿命の延伸を目的とした老化研究が現在盛んに行われています。近年、加齢に伴い生じる２つの現象、すなわち「老化細胞の蓄積」と「常在細菌叢の乱れ」の老化への関与が注目されています。本研究では、宿主と共生関係にある常在細菌叢を生体ストレスの一つとして捉え、常在細菌叢が老化の進行に与える影響の解明を目指します。

  2. 腸内細菌によるT細胞変容を介した組織老化促進メカニズムの解明

    河本 新平

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2026/04/01 - 2029/03/31

  3. Elucidating the mechanism of skin aging by skin bacteria and cellular senescence

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Osaka University

    2023/04/01 - 2026/03/31

  4. Impact of skin bacteria and cellular senescence on cutaneous tumor malignant conversion

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Osaka University

    2020/04/01 - 2023/03/31

  5. Elucidation of the role of p16INK4a in aging process of gut immune system and microbiota

    Kawamoto Shimpei

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Osaka University

    2018/04/01 - 2020/03/31

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    The human gastrointestinal tract harbours a complex community of microorganisms, called the gut microbiota. Although it has known that an imbalance of gut microbiota, named dysbiosis is generated through aging, its mechanism has not been clarified. This study revealed that the increase of p16INK4 expression in T or B cells through aging affects the immunoglobulin A production in Peyer's patches, leading to dysbiosis of gut microbiota.

  6. The influence of TCR specificity of T follicular helper cells on gut IgA production

    KAWAMOTO SHIMPEI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: The Institute of Physical and Chemical Research

    2013/04/01 - 2015/03/31

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    Foxp3+ T cells play a critical role for the maintenance of immune tolerance. We show that in mice, Foxp3+ T cells contributed to diversification of gut microbiota, particularly of species belonging to Firmicutes, Clostridia. Diversified and selected immunoglobulin A (IgA)s, which are regulated by Foxp3+ T cells in germinal centers (GCs) of Peyer’s patches, contributed to maintenance of diversified and balanced microbiota, which in turn facilitated the expansion of Foxp3+ T cells, induction of GCs, and IgA responses in the gut through a symbiotic regulatory loop. Thus, the adaptive immune system, through cellular and molecular components that are required for immune tolerance and through the diversification as well as selection of antibody repertoire, mediates host-microbial symbiosis by controlling the richness and balance of bacterial communities required for homeostasis.

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