Details of the Researcher

PHOTO

Takeshi Kawabe
Section
Graduate School of Medicine
Job title
Associate Professor
Degree

  • 博士（医学）（東北大学）

Research History 6

  • 2020/10 - Present
    Tohoku University　Graduate School of Medicine

  • 2018/11 - 2020/09
    Tohoku University　Graduate School of Medicine

  • 2013/12 - 2018/10
    米国立衛生研究所　国立アレルギー・感染症研究所　博士研究員

  • 2016/01 - 2017/12
    日本学術振興会　海外特別研究員NIH

  • 2013/04 - 2013/11
    Tohoku University

  • 2011/04 - 2013/03
    日本学術振興会　特別研究員DC2

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Education 2

  • Tohoku University　Graduate School of Medicine

    - 2013/03

  • Tohoku University　Faculty of Medicine　School of Medicine

    - 2007/03

Professional Memberships 2

  • International Cytokine and Interferon Society

  • 日本免疫学会

Research Interests 5

  • ホメオスタシス

  • 腫瘍免疫

  • 感染免疫

  • 自己免疫・炎症性疾患

  • T細胞

Research Areas 1

  • Life sciences / Immunology /

Awards 18

  1. 医学奨励賞

    2023/12　MSD生命科学財団

  2. 研究奨励賞

    2022/12　日本免疫学会

  3. 医学研究奨励賞

    2021/11　日本医師会

  4. インテリジェントコスモス奨励賞

    2021/05　インテリジェントコスモス学術振興財団

  5. 勾坂記念賞

    2021/04　艮陵医学振興会

  6. 渡辺記念特別奨励賞

    2021/03　宇部興産学術振興財団

  7. 医学奨励賞

    2021/01　宮城県医師会

  8. 坂田賞

    2021/01　東北大学 医学部

  9. 医学部奨学賞 銀賞

    2021/01　東北大学 医学部

  10. Milstein Abstract Award

    2020/11　International Cytokine & Interferon Society

  11. Outstanding Young Immunology Researcher Award

    2019/12　日本免疫学会

  12. 北斗医学賞

    2019/10　日本細菌学会 東北支部会

  13. NIH-Japan-JSPS Symposium Travel Award

    2019/10　NIH-Japan-JSPS Symposium

  14. Tadamitsu Kishimoto International Travel Award

    2019/10　日本免疫学会

  15. Milstein Travel Award

    2017/11　International Cytokine & Interferon Society

  16. 辛酉優秀学生賞

    2014/03　東北大学大学院医学系研究科

  17. Ursula and Fritz Melchers Travel Award

    2012/12　日本免疫学会

  18. JSI Young investigators’ travel award for 14th ICI

    2010/08　日本免疫学会

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Papers 32

  1. Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation

    Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Hibiki Suzuki, Jing Li, Ziying Yang, Ryoji Mitsuwaka, Akihisa Kawajiri, Kosuke Sato, Feng Gao, Taku Nakai, Yuko Okuyama, Tadahisa Numakura, Mitsuhiro Yamada, Tomoaki Ida, Masanobu Morita, Takeshi Kawabe, Takaaki Akaike, Naoto Ishii

    Frontiers in Immunology　16　2025/04/15

    Publisher: Frontiers Media SA

    DOI： 10.3389/fimmu.2025.1506580 　

    eISSN： 1664-3224

    More details Close

    Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation where CD4+ T lymphocytes play an essential role. Accumulating evidence suggests that immune responses driven by CD4+ T cells are critically regulated by various metabolic pathways including oxidative phosphorylation and glycolysis. Here we show that CARS2/CPERS-dependent supersulfide metabolism restrains CD4+ T cell proliferation in a cell-intrinsic manner. Under steady state, Cars2+/- mice exhibited spontaneous accumulation of effector/memory CD4+ T cells in the colon with age. In lymphopenic conditions, Cars2+/- CD4+ T cells showed enhanced cell cycle entry with reduced expression of a cell cycle inhibitor Trp53 and triggered an exacerbated form of colitis, the response being rescued by treatment with a supersulfide donor glutathione trisulfide (GSSSG). Furthermore, re-analysis of publicly available gene datasets of human colonic CD4+ T lymphocytes revealed that downregulation of CARS2 was associated with pathogenesis of IBD, and indeed, addition of GSSSG inhibited human CD4+ T cell proliferation in vitro. Together these observations reveal that CARS2/CPERS-dependent supersulfide metabolism is essential for homeostasis of intestinal effector/memory CD4+ T cells, and further suggest that dysregulation of the same metabolic pathway can lead to development of gut inflammation both in mice and humans.

  2. Naturally arising memory-phenotype CD4+ T lymphocytes give rise to multiple helper subsets to contribute to tumor immunity while inhibiting GVHD

    Ziying Yang, Jing Li, Hideaki Watanabe, Feng Gao, Akihisa Kawajiri, Keita Koinuma, Kosuke Sato, Yuko Okuyama, Shunichi Tayama, Yoichiro Iwakura, Naoto Ishii, Takeshi Kawabe

    Cancer Immunology Research　2025/04/01

    Publisher: American Association for Cancer Research (AACR)

    DOI： 10.1158/2326-6066.cir-24-0598 　

    ISSN： 2326-6066

    eISSN： 2326-6074

    More details Close

    Abstract Memory-phenotype (MP) CD4+ T lymphocytes spontaneously develop in steady state from peripheral naïve precursors in a manner dependent on self-antigen recognition. While MP cells possess innate type 1 and 3 effector functions that can contribute to host defense and autoimmunity, their immunological functions in tumor immunity and graft-versus-host disease (GVHD), which results from therapeutic bone marrow transplantation (BMT) against hematological malignancies, remain unclear. Here we show that in mixed lymphocyte reactions, MP lymphocytes can generate T helper 1 (Th1), T helper 17 (Th17), and regulatory T (Treg) cell subsets, whereas naïve cells dominantly differentiate to Th1. Consistent with this, naïve lymphocytes mainly induce Th1 responses in the mouse EL4 model of malignant lymphoma and the B16 model of malignant melanoma, whereas MP cells efficiently give rise to Th1, Th17, and Treg subsets to exert mild, IFN--dependent antitumor activities in vivo. Moreover, we demonstrate using a mouse model of BMT that MP cells more efficiently differentiate into Treg cells to partially suppress GVHD as compared to naïve T lymphocytes. Furthermore, our data suggest that when used as donor T lymphocytes in BMT in tumor-bearing mice, MP cells give rise to Th1, Th17, and Treg cells to generate antitumor responses without inducing GVHD. Together these results identify MP cells as a unique T-cell population that has potential to generate multiple T helper subsets including Th1 and Treg cells, thereby contributing to tumor immunity while inhibiting development of BMT-associated GVHD.

  3. Naturally arising memory-phenotype CD4+ T lymphocytes contain an undifferentiated population that can generate TH1, TH17, and Treg cells. Peer-reviewed

    Kawajiri A., Li J., Koinuma K., Yang Z., Yoon HJ, Yi J., Nagashima H., Ishii M., Gao F., Sato K., Tayama S., Harigae H., Iwakura Y., Ishii N., Sher A., Ishigaki K., Zhu J., Kim KS, Kawabe T.

    Sci Adv　10　(49)　eadq6618　2024/12

  4. Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state. Peer-reviewed

    Li J., Yang Z., Kawajiri A., Sato K., Tayama S., Ishii N., Zhu J., Kawabe T.

    Front Immunol　15　1429954　2024/08

  5. Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes. Invited Peer-reviewed

    Kawabe T

    Immunol Med　46　(1)　1-8　2023/03

  6. IL-33-ILC2 axis promotes anti-tumor CD8+ T cell responses via OX40 signaling. Peer-reviewed

    Okuyama Y, Okajima A, Sakamoto N, Hashimoto A, Tanabe R, Kawajiri A, Kawabe T, Ishii N

    Biochem Biophys Res Commun　637　9-16　2022/12

  7. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Peer-reviewed

    Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, Asano Y, Aiba S

    Sci Immunol　7　(76)　eabm9811　2022/10

  8. Memory-phenotype CD4+ T Lymphocytes: A Novel Therapeutic Target in Infectious or Autoimmune Diseases? Invited Peer-reviewed

    Kawabe T

    JMA J　5　(3)　298-306　2022/07

    Publisher: Japan Medical Association

    DOI： 10.31662/jmaj.2022-0048 　

    ISSN： 2433-328X

    eISSN： 2433-3298

  9. Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses. International-journal Peer-reviewed

    Kawabe T, Ciucci T, Kim KS, Tayama S, Kawajiri A, Suzuki T, Tanaka R, Ishii N, Jankovic D, Zhu J, Sprent J, Bosselut R, Sher A

    Front Immunol　13　870542　2022/05

    DOI： 10.3389/fimmu.2022.870542 　

    More details Close

    Under steady-state conditions, conventional CD4+ T lymphocytes are classically divided into naïve (CD44lo CD62Lhi) and memory (CD44hi CD62Llo) cell compartments. While the latter population is presumed to comprise a mixture of distinct subpopulations of explicit foreign antigen (Ag)-specific "authentic" memory and foreign Ag-independent memory-phenotype (MP) cells, phenotypic markers differentially expressed in these two cell types have yet to be identified. Moreover, while MP cells themselves have been previously described as heterogeneous, it is unknown whether they consist of distinct subsets defined by marker expression. In this study, we demonstrate using combined single-cell RNA sequencing and flow cytometric approaches that self-driven MP CD4+ T lymphocytes are divided into CD127hi Sca1lo, CD127hi Sca1hi, CD127lo Sca1hi, and CD127lo Sca1lo subpopulations that are Bcl2lo, while foreign Ag-specific memory cells are CD127hi Sca1hi Bcl2hi. We further show that among the four MP subsets, CD127hi Sca1hi lymphocytes represent the most mature and cell division-experienced subpopulation derived from peripheral naïve precursors. Finally, we provide evidence arguing that this MP subpopulation exerts the highest responsiveness to Th1-differentiating cytokines and can induce colitis. Together, our findings define MP CD4+ T lymphocytes as a unique, self-driven population consisting of distinct subsets that differ from conventional foreign Ag-specific memory cells in marker expression and establish functional relevance for the mature subset of CD127hi Sca1hi MP cells.

  10. Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation Peer-reviewed

    Fang D, Cui K, Cao Y, Zheng M, Kawabe T, Hu G, Khillan JS, Li D, Zhong C, Jankovic D, Sher A, Zhao K, Zhu J

    Immunity　55　(4)　639-655.e7　2022/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.immuni.2022.03.005 　

    ISSN： 1074-7613

  11. Memory-phenotype CD4+ T cells: a naturally arising T lymphocyte population possessing innate immune function Invited Peer-reviewed

    Kawabe T, Sher A

    Int Immunol　34　(4)　189-196　2022/03

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/intimm/dxab108 　

    eISSN： 1460-2377

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    Abstract In conventional adaptive immune responses, upon recognition of foreign antigens, naive CD4+ T lymphocytes are activated to differentiate into effector/memory cells. In addition, emerging evidence suggests that in the steady state, naive CD4+ T cells spontaneously proliferate in response to self-antigens to acquire a memory phenotype (MP) through homeostatic proliferation. This expansion is particularly profound in lymphopenic environments but also occurs in lymphoreplete, normal conditions. The ‘MP T lymphocytes’ generated in this manner are maintained by rapid proliferation in the periphery and they tonically differentiate into T-bet-expressing ‘MP1’ cells. Such MP1 CD4+ T lymphocytes can exert innate effector function, producing IFN-γ in response to IL-12 in the absence of antigen recognition, thereby contributing to host defense. In this review, we will discuss our current understanding of how MP T lymphocytes are generated and persist in steady-state conditions, their populational heterogeneity as well as the evidence for their effector function. We will also compare these properties with those of a similar population of innate memory cells previously identified in the CD8+ T lymphocyte lineage.

  12. Homeostasis of Naive and Memory T Lymphocytes. Invited Peer-reviewed

    Kawabe T, Yi J, Sprent J

    Cold Spring Harb Perspect Biol　13　(9)　a037879　2021/09

  13. GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity. International-journal Peer-reviewed

    Tsuyoshi Sakurai, Yuko Okuyama, Shuhei Kobayashi, Hai The Phung, Atsuko Asao, Takeshi Kawabe, Lishomwa C Ndhlovu, Carlo Riccardi, Hironori Kudo, Motoshi Wada, Masaki Nio, Takanori So, Naoto Ishii

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology　34　(11)　14820-14831　2020/11

    DOI： 10.1096/fj.202001675R 　

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    Glucocorticoid-induced TNFR family related gene (GITR) is a member of the TNFR superfamily that is expressed on cells of the immune system. Although the protective and pathogenic roles of GITR in T cell immunity are well characterized, the role of GITR in innate immunity in the intestinal tissues has not been well clarified. In this study, using a dextran sulfate sodium (DSS)-induced colitis model in mice, we found that GITR-deficiency rendered mice more susceptible to acute intestinal inflammation and that a significantly higher number of activated natural killer (NK) cells was accumulated in the colonic lamina propria of Gitr-/- mice as compared to wild-type mice. Additionally, Rag2-/- Gitr-/- mice, which lack T cells but have NK cells, also displayed more severe colonic inflammation than Rag2-/- mice. In contrast, an anti-GITR agonistic antibody significantly alleviated colitis in Rag2-/- mice. Engagement of GITR inhibited IL-15-mediated activating signaling events in NK cells, which include cell activation and proliferation, and production of cytokines and cytotoxic granules. Taken together, our results provide the first evidence that GITR negatively controls intestinal inflammation through NK cell functions.

  14. Germ-free conditions modulate host purine metabolism, exacerbating adenine-induced kidney damage. Peer-reviewed

    Mishima E, Ichijo M, Kawabe T, Kikuchi K, Akiyama Y, Toyohara T, Suzuki C, Suzuki T, Asao A, Ishii N, Fukuda S, Abe T

    Toxins　12　(9)　547　2020/08

  15. Requirements for the differentiation of innate T-bet(high) memory-phenotype CD4+ T lymphocytes under steady state Peer-reviewed

    Kawabe T, Yi J, Kawajiri A, Hilligan K, Fang D, Ishii N, Yamane H, Zhu J, Jankovic D, Kim KS, Trinchieri G, Sher A

    Nat Commun　11　(1)　3366　2020/07

  16. 'Rinse and Replace': Boosting T Cell Turnover To Reduce HIV-1 Reservoirs. Invited Peer-reviewed

    Grossman Z, Singh NJ, Simonetti FR, Lederman MM, Douek DC, Deeks SG, Contributing authors(Full authorship: Kawabe T, Bocharov G, Meier-Schellersheim M, Alon H, Chomont N, Grossman Z, Sousa AE, Margolis L, Maldarelli F)

    Trends Immunol　41　(6)　466-480　2020/06

  17. New insights on T-cell self-tolerance. Invited Peer-reviewed

    Yi J, Kawabe T, Sprent J

    Curr Opin Immunol　63　14-20　2020/04

  18. IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s. International-journal Peer-reviewed

    Shunichi Tayama, Yuko Okuyama, Hai The Phung, Atsuko Asao, Shuhei Kobayashi, Tomomi Musha, Tomoaki Machiyama, Tsuyoshi Sakurai, Chengming Zhang, Masuko Ushio-Fukai, Takeshi Kawabe, Takanori So, Naoto Ishii

    International immunology　32　(4)　233-241　2020/04

    DOI： 10.1093/intimm/dxz077 　

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    Group 2 innate lymphoid cells (ILC2s) play critical roles in type 2 immunity and are crucial for pathogenesis of various types of inflammatory disease. IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a ubiquitously expressed scaffold protein that is involved in multiple cellular functions such as cell survival and trafficking. While the roles for IQGAP1 in T and B lymphocytes have been uncovered, the physiological significance of IQGAP1 in innate lymphocytes remains to be elucidated. In the current study, we demonstrate that using bone marrow chimeras, the deficiency of IQGAP1 caused an impaired survival of lung ILC2s in a cell-intrinsic manner and that Iqgap1-/- mice displayed decreased accumulation of ILC2s after administration of papain and thereby reduced the pathology of the disease. Moreover, Iqgap1-/- ILC2s showed a significantly enhanced apoptosis as compared to wild-type ILC2s under both steady-state and inflammatory conditions. Together these results identify for the first time that IQGAP1 is essential for homeostasis of ILC2s in the lung.

  19. TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells. International-journal Peer-reviewed

    Hai The Phung, Hiroyuki Nagashima, Shuhei Kobayashi, Naoki Asano, Tomoaki Machiyama, Tsuyoshi Sakurai, Shun-Ichi Tayama, Atsuko Asao, Akira Imatani, Takeshi Kawabe, Yuko Okuyama, Naoto Ishii, Takanori So

    ImmunoHorizons　4　(3)　129-139　2020/03/10

    DOI： 10.4049/immunohorizons.2000007 　

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    TNFR-associated factor 5 (TRAF5) is a cytosolic adaptor protein and functions as an inflammatory regulator. However, the in vivo function of TRAF5 remains unclear, and how TRAF5 controls inflammatory responses in the intestine is not well understood. In this study, we found that intestinal epithelial cells from Traf5-/- mice expressed a significantly lower level of NF-κB-regulated proinflammatory genes, such as Tnf, Il6, and Cxcl1, as early as day 3 after dextran sulfate sodium (DSS) exposure when compared with wild-type mice. The intestinal barrier integrity of DSS-treated Traf5-/- mice remained intact at this early time point, and Traf5-/- mice showed decreased body weight loss and longer colon length at later time points. Surprisingly, the protein level of TRAF2, but not TRAF3, was reduced in colon tissues of Traf5-/- mice after DSS, indicating the requirement of TRAF5 for TRAF2 protein stability in the inflamed colon. Experiments with bone marrow chimeras confirmed that TRAF5 deficiency in nonhematopoietic cells caused the attenuated colitis. Our in vitro experiments demonstrated that proinflammatory cytokines significantly promoted the degradation of TRAF2 protein in Traf5-/- nonhematopoietic cells in a proteasome-dependent manner. Collectively, our data suggest a novel regulatory function of TRAF5 in supporting the proinflammatory function of TRAF2 in nonhematopoietic cells, which may be important for acute inflammatory responses in the intestine.

  20. TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors. International-journal Peer-reviewed

    Shuhei Kobayashi, Yuka Shiota, Takeshi Kawabe, Hai The Phung, Takashi Maruyama, Yuji Owada, Takanori So, Naoto Ishii

    Biochemical and biophysical research communications　521　(2)　353-359　2020/01

    DOI： 10.1016/j.bbrc.2019.10.123 　

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    The conventional dendritic cells (cDCs) and plasmacytoid DCs (pDCs) originate from the same common dendritic cell precursor cells in the bone marrow. The pDCs produce large amounts of type 1 interferon in response to foreign nucleic acid and crucially contribute to host defense against viral infection. Tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) is a pivotal component of various TNF receptor signaling pathways in the immune system. Although the functions of TRAF5 in T and B lymphocytes have been well studied, its roles in pDCs remains to be fully elucidated. In this study, we show that the expression of TRAF5 supports the generation of pDCs in the bone marrow and also critically contributes to the homeostasis of the pDC subset in the periphery in a cell-intrinsic manner. Furthermore, we provide evidence that TRAF5 promotes the commitment of DC precursor cells toward pDC versus cDC subsets, which is regulated by the balance of transcription factors TCF4 and ID2. Together our findings reveal that TRAF5 acts as a positive regulator of pDC differentiation from bone marrow progenitors.

  21. Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells. Peer-reviewed

    Lee PH, Yamamoto TN, Gurusamy D, Sukumar M, Yu Z, Hu-Li J, Kawabe T, Gangaplara A, Kishton RJ, Henning AN, Vodnala SK, Germain RN, Paul WE, Restifo NP

    J Exp Med　216　(11)　2619-2634　2019/11

  22. TNF Receptor-Associated Factor 5 Limits Function of Plasmacytoid Dendritic Cells by Controlling IFN Regulatory Factor 5 Expression. Peer-reviewed

    Kobayashi S, Sakurai T, So T, Shiota Y, Asao A, Phung HT, Tanaka R, Kawabe T, Maruyama T, Kanno E, Kawakami K, Owada Y, Ishii N

    J Immunol　203　(6)　1447-1456　2019/09

  23. Foreign antigen-independent memory-phenotype CD4+ T cells: a new player in innate immunity? Invited Peer-reviewed

    Kawabe T, Zhu J, Sher A

    Nat Rev Immunol　18　(3)　1　2018/02

  24. S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. Peer-reviewed

    Huang Y, Mao K, Chen X, Sun MA, Kawabe T, Li W, Usher N, Zhu J, Urban JF Jr, Paul WE, Germain RN

    Science.　359　(6371)　114-119　2018/01

  25. Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function. Peer-reviewed

    Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee PH, Yamane H, Zhu J, Sher A, Germain RN, Paul WE

    Sci Immunol.　2　(12)　eaam9304　2017/06

  26. The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells Peer-reviewed

    Immunity　46　(6)　983-991　2017/06

    DOI： 10.1016/j.immuni.2017.05.005 　

    ISSN： 1074-7613

    eISSN： 1097-4180

  27. Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice Peer-reviewed

    Kawabe T, Suzuki N, Yamaki S, Sun SL, Asao A, Okuyama Y, So T, Iwakura Y, Ishii N

    Eur J Immunol　46　(5)　1119-1131　2016/05

    DOI： 10.1002/eji.201545907 　

    ISSN： 0014-2980

    eISSN： 1521-4141

  28. OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. Peer-reviewed

    Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, Ichinose M

    EMBO Mol Med.　8　(4)　422-36　2016/04

    DOI： 10.15252/emmm.201506154 　

  29. OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells Peer-reviewed

    Yamaki S, Ine S, Kawabe T, Okuyama Y, Suzuki N, Soroosh P, Mousavi SF, Nagashima H, Sun SL, So T, Sasaki T, Harigae H, Sugamura K, Kudo H, Wada M, Nio M, Ishii N

    Eur J Immunol　44　(10)　3015-3025　2014/10

    DOI： 10.1002/eji.201444701 　

    ISSN： 0014-2980

    eISSN： 1521-4141

  30. The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Peer-reviewed

    Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N, So T

    Nat Immunol　15　(5)　449-56　2014/05

    DOI： 10.1038/ni.2863 　

    ISSN： 1529-2908

    eISSN： 1529-2916

  31. Y chromosome-linked B and NK cell deficiency in mice Peer-reviewed

    Shu-Lan Sun, Satoshi Horino, Ari Itoh-Nakadai, Takeshi Kawabe, Atsuko Asao, Takeshi Takahashi, Takanori So, Ryo Funayama, Motonari Kondo, Hirotomo Saitsu, Naomichi Matsumoto, Keiko Nakayama, Naoto Ishii

    Journal of Immunology　190　(12)　6209-6220　2013/06/15

    DOI： 10.4049/jimmunol.1300303 　

    ISSN： 0022-1767 1550-6606

  32. Homeostatic Proliferation of Naive CD4+ T Cells in Mesenteric Lymph Nodes Generates Gut-Tropic Th17 Cells Peer-reviewed

    Kawabe T, Sun SL, Fujita T, Yamaki S, Asao A, Takahashi T, So T, Ishii N

    J Immunol　190　(11)　5788-5798　2013/06

    DOI： 10.4049/jimmunol.1203111 　

    ISSN： 0022-1767

Show all ︎Show first 5

Misc. 23

  1. 自己抗原認識T細胞. Invited

    河部剛史

    臨床免疫アレルギー科　82　(6)　2024

  2. Tリンパ球の恒常性維持における自己反応性の新たな役割 Invited

    河部剛史

    医学のあゆみ　291　(8)　24983-24986　2024

  3. 自己反応性Memory-phenotype CD4+ T細胞 Invited

    河部剛史

    炎症と免疫　32　(5)　384-388　2024

  4. Regulatory T cells tonically inhibit spontaneous activation of naturally arising memory-phenotype CD4+ T lymphocytes. Peer-reviewed

    Li J., Yang Z., Kawajiri A., Sato K., Tayama S., Ishii N., Kawabe T.

    J Immunol　212　(S1)　0194_4767　2024

  5. Memory-phenotype T細胞 Invited

    河部剛史

    臨床免疫アレルギー科　80　(3)　279-285　2023

  6. CD127 and Sca1 mark self-driven memory-phenotype CD4 +T cells that differ from foreign antigen-specific memory cells and possess inflammatogenic and anti-tumor activities. Peer-reviewed

    Kawabe T, Ciucci T, Kim KS, Yang Z, Kawajiri A, Tayama S, Ishii N, Jankovic D, Zhu J, Sprent J, Bosselut R, Sher A

    J Immunol　210　(S1)　76.08　2023

  7. Self antigen-driven, undifferentiated memory-phenotype CD4 T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells. Peer-reviewed

    Kawajiri A, Li J, Yang Z, Koinuma K, Yoon HJ, Ishii M, Tayama S, Sato K, Okuyama Y, Harigae H, Ishii N, Ishigaki K, Zhu J, Kim KS, Kawabe T

    J Immunol　210　(S1)　76.09　2023

  8. Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation. Peer-reviewed

    Tayama S, Kitamura Y, Hiraide K, Li J, Yang Z, Kawajiri A, Sato K, Okuyama Y, Kawabe T, Akaike T, Ishii N

    J Immunol　210　(S1)　61.01　2023

  9. 2型自然リンパ球における足場蛋白質IQGAP1の新たな役割. Invited

    田山舜一, 河部剛史, 石井直人

    臨床免疫・アレルギー科　74　(3)　226-233　2020/09

  10. IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s. Peer-reviewed

    Tayama S, Okuyama Y, Phung HT, Asao A, Kobayashi S, Kawabe T, So T, Ishii N

    J Immunol　204　(S1)　147.4　2020

  11. IL-12 derived from CD8a+ dendritic cells drives the differentiation of innate-like T-bet(high) memory-phenotype CD4+ T lymphocytes in steady state. Peer-reviewed

    Kawabe T, Yi J, Kawajiri A, Hilligan K, Fang D, Ishii N, Yamane H, Zhu J, Jankovic D, Kim KS, Trinchieri G, Sher A

    J Immunol　204　(S1)　81.18　2020

  12. Differentiation of innate-like T-bet(high) memory-phenotype CD4+ T lymphocytes is promoted by homeostatic IL-12 derived from CD8a+ dendritic cells in steady state. Peer-reviewed

    Kawabe T, Yi J, Yamane H, Zhu J, Jankovic D, Kim KS, Trinchieri G, Sher A

    Eur J Immunol　49　(S3)　404　2019

  13. T-bet+ memory-phenotype CD4+ T cells are spontaneously generated via tonic IL-12 in steady state and exert cytokine-dependent, innate-like effector function. Peer-reviewed

    Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee PH, Yamane H, Zhu J, Sher A, Germain RN, Paul WE

    Cytokine　100　(S)　53-54　2017/12

    ISSN： 1043-4666

    eISSN： 1096-0023

  14. T-bet suppresses the IFN-gamma mediated induction of a T cell intrinsic type I IFN signature during T helper 1 responses. Peer-reviewed

    Mikami Y, Davis F, Iwata S, Sun HW, Brooks SR, Shih HY, Kawabe T, Jiang K, Jankovic D, Sher A, Kanno Y, O'Shea JJ

    Cytokine　100　(S)　42-42　2017/12

    ISSN： 1043-4666

    eISSN： 1096-0023

  15. Memory-phenotype CD4+ T cells spontaneously generated under steady state conditions exert innate Th1-like effector function. Peer-reviewed

    Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee PH, Yamane H, Zhu J, Sher A, Germain RN, Paul WE

    J Immunol　198　(S1)　150.4　2017/05

    ISSN： 0022-1767

    eISSN： 1550-6606

  16. Inflammatory ILC2: An IL-25-activated circulating ILC population with a protective role during helminthic infection Peer-reviewed

    Huang Y, Mao K, Chen X, Kawabe T, Li W, Zhu J, Urban JF, Germain RN, Paul WE

    J Immunol　198　(S1)　68.13　2017/05

    ISSN： 0022-1767

    eISSN： 1550-6606

  17. CD4+ T cell-intrinsic TRAF5 negatively regulates Th17 cell-dependent experimental autoimmune encephalomyelitis. Peer-reviewed

    Nagashima H, Okuyama Y, Hayashi T, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N, So T

    Eur J Immunol　46　(S1)　869-869　2016/08

    ISSN： 0014-2980

    eISSN： 1521-4141

  18. TRAF adaptors limit IL-6 receptor signaling through an unexpected binding to the signaling transducer receptor gp130. Peer-reviewed

    So T, Nagashima H, Okuyama Y, Hayashi T, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N

    Eur J Immunol　46　(S1)　23-24　2016/08

    ISSN： 0014-2980

    eISSN： 1521-4141

  19. Tissue-resident ILC2 and inflammatory ILC2: two distinct ILC populations. Peer-reviewed

    Huang Y, Mao K, Chen X, Kawabe T, Zhu J, Urban JF, Germain RN, Paul WE

    Eur J Immunol　46　(S1)　297-297　2016

  20. エフェクター記憶CD4陽性T細胞の恒常性維持増殖におけるOX40およびIL‐7の役割

    山木聡史, 井根省二, 河部剛史, 宗孝紀, 工藤博典, 仁尾正記, 石井直人

    日本小児外科学会雑誌　50　(3)　695-695　2014/04/25

    Publisher: (NPO)日本小児外科学会

    ISSN： 0288-609X

  21. OX40(CD134)-OX40リガンド標的. Invited

    河部剛史, 石井直人

    炎症と免疫.　21　(3)　208-212　2013/05

  22. B細胞分化と維持の制御プログラム Y染色体連鎖遺伝を示すB細胞欠損症の解析(Y chromosome-linked B cell deficiency in mice)

    Sun Shulan, 河部 剛史, 宗 孝紀, 高橋 武司, 石井 直人

    日本免疫学会総会・学術集会記録　40　142-142　2011/11

    Publisher: (NPO)日本免疫学会

    ISSN： 0919-1984

  23. 臓器特異的自己免疫疾患の発症におけるOX40シグナルの関与. Invited

    河部剛史, 石井直人

    炎症と免疫.　18　(6)　628-636　2010/11

Show all ︎Show first 5

Books and Other Publications 3

  1. 実験医学・ヒト免疫細胞サブセット最新研究

    河部剛史

    羊土社　2024/07

  2. Science - Japanese Scientists in Science 2018 -

    Huang Y, 河部剛史, Germain RN

    AAAS　2019/03

  3. seriesモデル動物利用マニュアル 疾患モデルの作製と利用 免疫疾患

    河部剛史, 石井直人

    エル・アイ・シー　2011/06

Presentations 88

  1. Naturally arising memory-phenotype CD4+ T lymphocytes differentiate into Th1, Th17, and Treg cells to contribute to tumor immunity while inhibiting graft-versus-host disease.

    Gao F., Yang Z., Li J., Kawajiri A., Sato K., Tayama S., Ishii N., Kawabe T.

    2024/12/04

  2. Naturally arising memory-phenotype CD4+ T lymphocytes rapidly accumulate in ischemic organs to exacerbate the tissue injury in an innate manner.

    Sato K., Kawajiri A., Li J., Yang Z., Tayama S., Matsuda K., Oda C., Shibuya A., Wada M., Ishii N., Kawabe T.

    2024/12/03

  3. Generation and Activation of naturally arising memory-phenotype CD4+ T lymphocytes are homeostatically restricted by regulatory T cells dependently of TCR, CD28, and IL-2 signaling.

    Li J., Yang Z., Kawajiri A., Sato K., Tayama S., Ishii N., Kawabe T.

    2024/12/04

  4. Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation.

    Tayama S., Kitamura Y., Hiraide K., Suzuki H., Li J., Yang Z., Sato K., Kawajiri A., Okuyama Y., Kawabe T., Akaike T., Ishii N.

    2024/12/03

  5. Memory-phenotype CD4+ T cells differentiate into Th1 and Treg cells to contribute to tumor immunity while inhibiting GVHD.

    Yang Z., Li J., Watanabe H., Kawajiri A., Koinuma K., Sato K., Okuyama Y., Tayama S., Iwakura Y., Ishii N., Kawabe T.

    12th Annual Meeting of the International Cytokine & Interferon Society　2024/10/21

  6. Naturally arising memory-phenotype CD4+ T lymphocytes contain an undifferentiated subpopulation that can differentiate into functional Th1, Th17, and Treg cells

    Kawajiri A., Li J., Yang Z., Yoon HJ, Yi J., Nagashima H., Sato K., Tayama S., Harigae H., Iwakura Y., Ishii N., Ishigaki K., Zhu J., Kim KS, Kawabe T.

    12th Annual Meeting of the International Cytokine & Interferon Society　2024/10/21

  7. 新たな自然免疫型Tリンパ球「MP細胞」の免疫学的意義 Invited

    河部剛史

    第3回日本医学会連合Rising Star　2024/06/20

  8. T細胞自己反応性の持つ生理的・病理的意義 Invited

    河部剛史

    第33回KTCC　2024/06/14

  9. Regulatory T cells tonically inhibit spontaneous activation of naturally arising memory-phenotype CD4+ T lymphocytes.

    Li J., Yang Z., Kawajiri A., Sato K., Tayama S., Ishii N., Kawabe T.

    Annual Meeting of the American Association of Immunologists　2024/03/05

  10. Regulatory T cells tonically inhibit spontaneous activation of naturally arising memory-phenotype CD4+ T lymphocytes.

    Li J., Yang Z., Kawajiri A., Sato K., Tayama S., Ishii N., Kawabe T.

    2024/01/17

  11. Mitochondrial cysteinyl-tRNA synthetase (CARS2) -dependent sulfur metabolism exacerbates a mouse model of multiple sclerosis through antigen presentation.

    Suzuki H., Hiraide K., Kitamura Y., Tayama S., Sato K., Koinuma K., Okuyama Y., Kawabe T., Akaike T., Ishii N.

    2024/01/19

  12. Memory-phenotype CD4+ T lymphocytes rapidly accumulate in ischemic organs and exacerbate tissue injury in an innate manner.

    Sato K., Kawajiri A., Li J., Yang Z., Tayama S., Matsuda K., Oda C., Shibuya A., Wada M., Ishii N., Kawabe T.

    2024/01/17

  13. Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation.

    Tayama S., Kitamura Y., Hiraide K., Suzuki H., Li J., Yang Z., Sato K., Kawajiri A., Okuyama Y., Kawabe T., Akaike T., Ishii N.

    2024/01/18

  14. Memory-Phenotype CD4+ T Lymphocytes Can Contribute to Tumor Control without Inducing Graft-versus-Host Disease.

    Yang Z., Li J., Watanabe H., Koinuma K., Kawajiri A., Sato K., Tayama S., Okuyama Y., Ishii N., Kawabe T.

    2024/01/19

  15. T細胞自己反応性の持つ免疫学的意義を再考する Invited

    河部剛史

    第10回T-cell seminar　2023/11/29

  16. Self-driven memory-phenotype cells: a naturally arising CD4+ T lymphocyte population possessing innate immune function Invited

    Takeshi Kawabe

    The RIKEN IMS-JSI International Symposium on Immunology 2023　2023/06/30

  17. CD127 and Sca1 mark self-driven memory-phenotype CD4+ T cells that differ from foreign antigen-specific memory cells and possess inflammatogenic and anti-tumor activities

    Takeshi Kawabe, Thomas Ciucci, Kwang Soon Kim, Ziying Yang, Akihisa Kawajiri, Shunichi Tayama, Naoto Ishii, Dragana Jankovic, Jinfang Zhu, Jonathan Spren, Rémy Bosselu, Alan Sher

    Annual Meeting of The American Association of Immunologists 2023　2023/05/12

  18. Self antigen-driven, undifferentiated memory-phenotype CD4+ T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells

    Akihisa Kawajiri, Jing Li, Ziying Yang, Keita Koinuma, Hye Jin Yoo, Minami Ishii, Shunichi Tayama, Kosuke Sato, Yuko Okuyama, Hideo Harigae, Naoto Ishii, Kazuyoshi Ishigaki, Jinfang Zhu, Kwang Soon Kim, Takeshi Kawabe

    Annual Meeting of The American Association of Immunologists 2023　2023/05/12

  19. Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation

    Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Yuko Okuyama, Takeshi Kawabe, Takaaki Akaike, Naoto Ishii

    Annual Meeting of The American Association of Immunologists 2023　2023/05/13

  20. 新規の自然免疫型T細胞の機能制御による新たな感染症治療戦略の創出 Invited

    河部 剛史

    第6回先進医薬研究報告会　2022/12/09

  21. ILC2-derived OX40L-OX40 signal promotes cytotoxic CD8+ T cell-mediated antitumor immunity in murine melanoma.

    Yuko Okuyama, Akira Okajima, Nao Sakamoto, Ryuto Tanabe, Ayaka Hashimoto, Atsuko Asao, Ziying Yang, Akihisa Kawajiri, Takeshi Kawabe, Naoto Ishii

    第51回日本免疫学会学術集会　2022/12/09

  22. Immunological Functions of Memory-Phenotype CD4+ T lymphocytes in Anti-Tumor Responses and Graft-versus-Host Disease.

    Ziying Yang, Hideaki Watanabe, Jing Li, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe

    第51回日本免疫学会学術集会　2022/12/08

  23. Rapid accumulation of circulating memory-phenotype CD4+ T lymphocytes in the gut critically contributes to tissue injury driven by intestinal ischemia and reperfusion.

    Kosuke Sato, Jing Li, Ziying Yang, Akihisa Kawajiri, Shunichi Tayama, Yuko Okuyama, Motoshi Wada, Naoto Ishii, Takeshi Kawabe

    第51回日本免疫学会学術集会　2022/12/08

  24. Mitochondrial cysteinyl-tRNA synthetase (CARS2)-dependent sulfur metabolism exacerbates experimental autoimmune encephalomyelitis in mice.

    Kyoga Hiraide, Yuya Kitamura, Shunichi Tayama, Yuko Okuyama, Kosuke Sato, Hibiki Suzuki, Keita Koinuma, Takeshi Kawabe, Naoto Ishii

    第51回日本免疫学会学術集会　2022/12/07

  25. Self-reactive memory-phenotype CD4+ T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells.

    Akihisa Kawajiri, Jing Li, Ziying Yang, Keita Koinuma, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Hideo Harigae, Naoto Ishii, Jinfang Zhu, Kwang Soon Kim, Takeshi Kawabe

    第51回日本免疫学会学術集会　2022/12/07

  26. Phenotypic and functional analyses reveal self-driven memory-phenotype CD4+ T lymphocytes as a heterogeneous population distinct from foreign antigen-specific memory cells.

    Takeshi Kawabe, Thomas Ciucci, Kwang Soon Kim, Shunichi Tayama, Akihisa Kawajiri, Naoto Ishii, Dragana Jankovic, Jinfang Zhu, Jonathan Sprent, Remy Bosselut, Alan Sher

    第51回日本免疫学会学術集会　2022/12/08

  27. CARS2-dependent sulfur metabolism controls intestinal inflammation by suppressing CD4+ T cell proliferation.

    Shunichi Tayama, Takeshi Kawabe, Kyoga Hiraide, Jing Li, Ziying Yang, Kosuke Sato, Akihisa Kawajiri, Yuko Okuyama, Naoto Ishii

    第51回日本免疫学会学術集会　2022/12/07

  28. Excess proliferation and activation of self-reactive memory-phenotype CD4+ T lymphocytes are tonically inhibited by regulatory T cells in steady state.

    Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe

    第51回日本免疫学会学術集会　2022/12/07

  29. 自己抗原反応性Memory-phenotype CD4+T細胞の炎症惹起能

    川尻昭寿, 李静, 楊子嬰, 鯉沼佳太, 佐藤皓祐, 田山舜一, 奥山祐子, 張替秀郎, 石井直人, 河部剛史

    第74回日本細菌学会東北支部会学術集会　2022/08/23

  30. Memory-phenotype cells: naturally arising CD4+ T lymphocytes possessing innate immune function Invited

    Takeshi Kawabe

    Symposium in honor of Dr. Alan Sher and IBS/LPD scientific achievements - Critical cooperation at the interface between infection and immunity -　2022/06/02

  31. 新規Tリンパ球の同定ならびにその生理学的・病理学的意義の解明 Invited

    河部剛史

    化血研第1回研究報告会　2022/03/10

  32. Characterization and composition of innate lymphoid cells in pediatric and adult allergic patients

    Yuko Okuyam, Tomomi Musha, Mizuna Fujit, Takeshi Kawabe, Atsuko Asao, Rina Morishit, Toshiya Takahashi, Maki Ozawa, Kenshi Yamasaki, Yohei Watanabe, Satoshi Horino, Yuji Sait, Yuji Nagano, Masaki Abe, Setsuya Aiba, Katsushi Miura, Naoto Ishii

    第50回日本免疫学会学術集会　2021/12/10

  33. Reactive sulfide species generated by cysteinyl-tRNA synthetase plays a regulatory role in T cell-induced colitis in a T cell-intrinsic manner

    Shunichi Tayama, Takeshi Kawabe, Yuya Kitamura, Kyoga Hiraide, Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Yuko Okuyam, Masanobu Morit, Takaaki Akaike, Naoto Ishii

    第50回日本免疫学会学術集会　2021/12/09

  34. Inflammatory potential of self-driven memory-phenotype CD4+ T cells

    Akihisa Kawajiri, Minami Ishii, Li Jing, Yang Ziying, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Harigae Hideo, Naoto Ishii, Takeshi Kawabe

    第50回日本免疫学会学術集会　2021/12/09

  35. IL-12 derived from type 1 dendritic cells tonically promotes the differentiation of innate T-bet(high) memory-phenotype CD4+ T lymphocytes in steady state

    Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher

    第50回日本免疫学会学術集会　2021/12/10

  36. 新規Tリンパ球「MP細胞」の恒常性維持機構の解明ならびにその自己免疫活性の究明 Invited

    河部 剛史

    第8回JCRベーシックリサーチカンファレンス　2021/11/13

  37. 新たなCD4 T細胞「MP細胞」の産生・分化機構とその病理学的機能の解明 Invited

    河部 剛史

    第49回日本臨床免疫学会総会　2021/10/28

  38. T細胞恒常性維持増殖の免疫学的意義 Invited

    河部剛史

    勾坂記念賞授与式　2021/04/19

  39. 新たな自然免疫型T細胞の同定とその機能解析 Invited

    河部 剛史

    医学部奨学賞授与式　2021/01/14

  40. 新規のT細胞「MP細胞」による感染防御および自己免疫疾患発症機構の解明 Invited

    河部 剛史

    先進医薬研究報告会　2020/12/11

  41. Differentiation of a novel memory-phenotype CD4+ T lymphocyte population and its immunological significance Invited

    Takeshi Kawabe

    第49回日本免疫学会学術集会　2020/12/08

  42. IL-12 derived from type 1 dendritic cells tonically promotes the differentiation of innate T-bet(high) memory-phenotype CD4+ T lymphocytes in steady state

    Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher

    Cytokines 2020　2020/11/01

  43. IL-12 derived from CD8a+ dendritic cells drives the differentiation of innate-like T-bet(high) memory-phenotype CD4+ T lymphocytes in steady state

    Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher

    Immunology 2020, Cancelled due to COVID-19

  44. T-bet(hi) memory-phenotype CD4 T cells are spontaneously generated in steady state and exert innate Th1-like effector function.

    Takeshi Kawabe

    Interdisciplinary seminar on mucosal immunology at Tohoku University 2020　2020/02/19

  45. T-bet(hi) memory-phenotype CD4(+) T cells are spontaneously generated in steady state and exert innate Th1-like effector function

    Takeshi Kawabe, Dragana Jankovic, Hidehiro Yamane, Jinfang Zhu, William E. Paul, Ronald N. Germain, Alan Sher

    第48回日本免疫学会学術集会　2019/12/11

  46. Differentiation of innate T-bet(hi) memory-phenotype CD4(+) T lymphocytes is promoted by homeostatic IL-12 derived from CD8a(+) type 1 dendritic cells in steady state International-presentation

    Takeshi Kawabe, Jaeu Yi, Hidehiro Yamane, Difeng Fang, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher

    NIH-Japan-JSPS Symposium　2019/10/28

  47. Differentiation of innate-like T-bet(high) memory-phenotype CD4(+) T lymphocytes is promoted by homeostatic IL-12 derived from CD8a(+) dendritic cells in steady state International-presentation

    Takeshi Kawabe, Jaeu Yi, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher

    17th International Congress of Immunology　2019/10/19

  48. MP細胞 ～自然免疫と獲得免疫の連続性～ Invited

    河部 剛史

    北斗医学賞授賞式　2019/10/05

  49. 新規のCD4 T細胞サブセット「MP細胞」の産生機構およびその自然免疫的感染防御機能

    河部剛史, 川尻昭寿, 石井直人, Ronald N Germain, Alan Sher, William E Paul

    第73回日本細菌学会東北支部総会　2019/08/23

  50. Differentiation of innate-like T-bet(hi) memory-phenotype CD4(+) T lymphocytes is promoted by homeostatic IL-12 derived from CD8a(+) dendritic cells in steady state International-presentation

    Takeshi Kawabe

    LPD Seminar　2019/05/09

  51. MP細胞 〜自然免疫と獲得免疫の連続性〜 International-presentation Invited

    河部 剛史

    第154回金曜会　2019/04/19

  52. "Endless Fascination" Invited

    河部 剛史

    東北大学免疫学分野セミナー　2018/11/05

  53. Innate-like T-bet(hi) memory-phenotype CD4+ T lymphocytes are homeostatically generated via tonic IL-12 signaling derived from CD8a+ dendritic cells. International-presentation

    Takeshi Kawabe, Dragana Jankovic, Jinfang Zhu, Giorgio Trinchieri, Alan Sher

    NIH Immunology Interest Group 2018 Workshop.　2018/09/05

  54. T-bet+ memory-phenotype CD4+ T cells spontaneously generated via tonic IL-12 in steady state exert innate Th1-like effector function. International-presentation

    Takeshi Kawabe

    CIG symposium, NIH.　2018/06/18

  55. Memory-phenotype CD4+ T cells ~a new player in innate immunity~. International-presentation Invited

    Takeshi Kawabe

    JSPS-NIH forum.　2018/03/09

  56. Memory-phenotype CD4+ T cells ~a new player in innate immunity~. International-presentation

    Takeshi Kawabe

    LPD seminar.　2018/03/08

  57. Memory-phenotype T cells ~bridging innate and adaptive immunity~. International-presentation Invited

    Takeshi Kawabe

    MITM seminar, The George Washington University.　2017/12/13

  58. MP細胞 ～自然免疫と獲得免疫の連続性～ Invited

    河部剛史

    第１回免疫科学コアセンターセミナー, 東北大学.　2017/11/02

  59. T-bet+ memory-phenotype CD4+ T cells are spontaneously generated via tonic IL-12 in steady state and exert cytokine-dependent, innate-like effector function. International-presentation

    Takeshi Kawabe, Dragana Jankovic, Shuko Kawabe, Yuefeng Huang, Ping-Hsien Lee, Hidehiro Yamane, Jinfang Zhu, Alan Sher, Ronald N Germain, William E Paul

    Cytokines 2017.　2017/10/29

  60. Innate-like T-bethi CXCR3+ memory-phenotype CD4+ T lymphocytes are spontaneously generated via IL-12 stimulation from CD8α+ dendritic cells. International-presentation

    Takeshi Kawabe, Dragana Jankovic, Jinfang Zhu, Ronald, N. Germain, Giorgio Trinchieri, Alan Sher

    NIH Immunology Interest Group 2017 Workshop.　2017/09/06

  61. Memory-phenotype CD4+ T cells spontaneously generated under steady state conditions exert innate Th1-like effector function. International-presentation

    Takeshi Kawabe, Dragana Jankovic, Shuko Kawabe, Yuefeng Huang, Ping-Hsien Lee, Hidehiro Yamane, Jinfang Zhu, Alan Sher, Ronald N Germain, William E Paul

    Immunology 2017.　2017/05/12

  62. Memory-phenotype CD4+ T cells generated in steady state conditions exert innate Th1-like effector function. International-presentation

    Takeshi Kawabe, Dragana Jankovic, Shuko Kawabe, Yuefeng Huang, Jinfang Zhu, Alan Sher, Ronald N Germain, William E Paul

    NIH Immunology Interest Group 2016 Workshop.　2016/09/07

  63. How are memory-phenotype CD4+ T cells generated and maintained in uninfected mice? International-presentation

    Takeshi Kawabe

    LPD seminar.　2016/06/16

  64. Homeostasis and innate immune function of memory-phenotype CD4+ T cells. International-presentation

    Takeshi Kawabe

    LI/LSB seminar.　2016/03/31

  65. Homeostasis and innate immune function of memory-phenotype CD4+ T cells International-presentation

    Takeshi Kawabe

    LI seminar.　2015/11/30

  66. Homeostasis and innate immune function of memory-phenotype CD4+ T cells. International-presentation

    Takeshi Kawabe, Dragana Jankovic, Jinfang Zhu, Alan Sher, William E Paul

    NIH Immunology Interest Group 2015 Workshop.　2015/09/09

  67. Conversion of naïve to memory phenotypes contributes to memory-phenotype CD4+ T cell generation in neonates and adults. International-presentation

    Takeshi Kawabe, William E. Paul

    NIH-Japan-JSPS symposium.　2014/10/23

  68. Neonatal lymphopenia induces memory-phenotype CD4+ T cell generation. International-presentation

    Takeshi Kawabe, William E. Paul

    NIH Immunology Interest Group 2014 Workshop.　2014/09/03

  69. Generation, maintenance, and function of memory-phenotype CD4+ T cells.

    Takeshi Kawabe

    LI/LSB Seminar　2014/04/02

  70. 腸管Th17細胞の産生における腸間膜リンパ節の役割.

    河部剛史, 孫舒嵐, 鈴木信, 山木聡史, 浅尾敦子, 宗孝紀, 石井直人

    第67回日本細菌学会東北支部総会.　2013/08/30

  71. Homeostatic proliferation of naïve CD4+ T cells in mesenteric lymph nodes generates gut-topic Th17 cells. International-presentation

    Takeshi Kawabe, Shu-lan Sun, Atsuko Asao, Takeshi Takahashi, Takanori So, Naoto Ishii

    15th International congress of immunology.　2013/08/22

  72. Th17 cell generation and mucosal immunity. International-presentation Invited

    Takeshi Kawabe, Takeshi Takahashi, Takanori So, Fujio Takeuchi, Kazuo Sugamura, Naoto Ishii

    Annual international symposium of rheumatology institute of Seoul national university hospital.　2013/06/28

  73. Homeostatic proliferation of naïve CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells. International-presentation

    Takeshi Kawabe, Shu-lan Sun, Satoshi Yamaki, Atsuko Asao, Takeshi Takahashi, Takanori So, Naoto Ishii

    NIH-Tohoku University-JSPS symposium.　2013/05/09

  74. 腸管Th17細胞の産生における腸間膜リンパ節の役割. Invited

    河部剛史

    第32回東北免疫研究会.　2013/03/29

  75. Homeostatic proliferation of naïve CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells. International-presentation Invited

    Takeshi Kawabe, Shu-lan Sun, Satoshi Yamaki, Atsuko Asao, Takeshi Takahashi, Takanori So, Naoto Ishii

    The 1st symposium of international immunological memory and vaccine forum.　2013/01/29

  76. 腸管T細胞の恒常性維持における腸間膜リンパ節の役割. Invited

    河部剛史

    第2回Multidisciplinary meeting on atherosclerosis.　2013/01/05

  77. Homeostatic proliferation occurs in mesenteric lymph nodes and supplies effector memory CD4+ T cells in the intestine.

    Takeshi Kawabe, Shu-lan Sun, Satoshi Yamaki, Atsuko Asao, Takeshi Takahashi, Takanori So, Naoto Ishii

    第41回日本免疫学会学術集会.　2012/12/05

  78. OX40 signaling contributes to the generation of effector memory CD4 T cells.

    Takeshi Kawabe, Shu-lan Sun, Satoshi Yamaki, Tsuyoshi Fujita, Takanori So, Takeshi Takahashi, Kazuo Sugamura, Naoto Ishii

    第40回日本免疫学会学術集会.　2011/11/27

  79. OX40 signaling and homeostatic proliferation of CD4 T cells. International-presentation

    Takeshi Kawabe, Shouji Ine, Pejman Soroosh, Takanori So, Takeshi Takahashi, Kazuo Sugamura, Naoto Ishii

    The 13th international TNF conference　2011/05/15

  80. Two distinct homeostatic proliferations of CD4 T cells.

    Takeshi Kawabe, Takeshi Takahashi, Naoto Ishii

    Network medicine winter camp of GCOE 2011.　2011/02/05

  81. ナイーブおよび記憶CD4 T細胞の恒常性維持機構の解明.

    河部剛史, 高橋武司, 石井直人

    第4回リトリート大学院生研究発表会.　2011/01/15

  82. CD4陽性T細胞の恒常性維持機構の解析.

    河部剛史

    がん医学コアセンター 第2回多面的プロモーションカンファレンス.　2010/11/10

  83. Positional identification of TNFRSF14, encoding the herpes virus entry mediator, as a susceptibility gene for inflammatory bowel disease in mice. International-presentation

    Takeshi Kawabe, Masahiro Irie, Masao Ono, Atsuko Asao, Ming-Cai Zhang, Ayumi Yoshida, Takeshi Takahashi, Toshimitsu Uede, Norihiko Watanabe, Kazuo Sugamura, Naoto Ishii

    14th International congress of immunology.　2010/08/22

  84. 免疫記憶成立の分子機構の解明.

    河部剛史, 孫舒嵐, 高橋武司, Seyed Fazlollah Mousavi, 石井直人

    第3回リトリート大学院生研究発表会　2010/01/09

  85. 特発性後腹膜線維症の一例.

    河部剛史, 吉田秀彦, 土屋朗之, 戸巻寛章, 北向修, 尾形公彦, 中角尚誉

    第186回日本内科学会東北地方会.　2008/09/20

  86. 癒着性イレウス手術における64列MDCTの有用性の検討.

    河部剛史, 藤原耕, 松田和久, 土屋朗之, 阿部忠義

    第63回日本消化器外科学会.　2008/07/16

  87. 癒着性イレウス手術例における64列MDCTの有用性の検討.

    河部剛史, 藤原耕, 松田和久, 土屋朗之, 阿部忠義

    第155回東北外科集談会.　2008/06/14

  88. 開胸手術歴のある患者に発症した心タンポナーデを伴う急性大動脈解離の一例.

    河部剛史, 富岡智子, 北向修, 尾形公彦, 佐藤昇一

    第183回日本内科学会東北地方会.　2007/09/01

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Research Projects 9

  1. 免疫恒常性におけるT細胞自己認識の新たな役割

    Offer Organization: 国立研究開発法人 科学技術振興機構

    System: 創発的研究支援事業

    Institution: 東北大学

    2024/10 - 2028/03

  2. Regulation of T cell immune responses by supersulfide

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  3. T細胞ホメオスタシスにおける自己反応性の新たな意義

    河部 剛史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 学術変革領域研究(A)

    Institution: 東北大学

    2023/04 - 2025/03

  4. 新たな自己反応性T細胞の恒常性維持機構ならびに生理的・病理的意義の解明 Competitive

    河部 剛史, 石井 直人

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04 - 2025/03

  5. T細胞の自然免疫機能に立脚した新たな感染症治療戦略の創出 Competitive

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2022/06 - 2024/03

  6. Revealing immune cell network formed by novel self-reactive T lymphocytes Competitive

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))

    Institution: Tohoku University

    2021/04 - 2024/03

  7. TNF受容体型補助刺激分子による自然リンパ球の制御機構

    奥山 祐子, 河部 剛史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    自然リンパ球（ILC）は、自然免疫系を担う新たなリンパ球系細胞として発見され、炎症反応を制御し生体恒常性維持と生体防御に重要な細胞として注目されている。なかでも２型自然リンパ球（ILC2）は、Th2サイトカインの産生を介してアレルギー性呼吸器炎症、寄生虫感染防御、アトピー性皮膚炎等の病態形成に関与する。 我々はTNF受容体型のT細胞補助刺激分子の一つであるGITR (Glucocorticoid induced tumor necrosisfactor receptor)がILC2に強く発現することを見いだした。そして、GITRシグナルが肺組織ILC2の増殖と活性化を促進し、アレルギー性肺炎症疾患の発症に寄与することを明らかにした。さらに、GITRリガンド(GITR-L)発現細胞の探索を進めたところ、炎症時ILC2自身にリガンドの発現が誘導されることを見出した。ILC2細胞上のGITR-LはILC2同士の相互作用による制御、およびT細胞に発現するGITRを介したT細胞の機能制御にも関与すると考えられる。そこで本研究は、ILCにおけるGITR補助刺激シグナルを介したアレルギー性炎症疾患の制御機構を明らかにすることを目的とする。 これまでの研究の結果、マウス由来ILC2についてIL-33刺激による活性化後、およびパパインによる炎症誘導後にGITR-Lの発現の亢進が認められ、GITR-L欠損マウスではILC2依存的な肺炎症病態が減弱した。さらに、今回新たにヒト末梢血由来ILC2を培養しin vitroにおいてサイトカイン刺激を行なったところ、活性化による補助刺激分子発現の変化が認められた。

  8. Identifying a novel self-reactive T cell subpopulation and its functional significance Competitive

    Kawabe Takeshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2020/04 - 2022/03

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    CD4 T lymphocytes are essential for useful adaptive immune responses. Among CD4 T cells, we have recently identified a subpopulation with a memory phenotype that arises from naive precursors dependently of self antigen recognition and can exert innate immune function in infectious conditions. Based on this finding, this study aimed to define markers for this subpopulation and unravel its host-protective as well as autoimmune functions. In this study, we identified three markers that specify MP versus foreign antigen-specific memory cells. Moreover, we found that MP cells contain a Th1-like “MP1" subset and this subpopulation can exert innate effector function. Furthermore, we are obtaining evidence arguing that MP cells can induce systemic inflammation in certain circumstances. Together our results suggest MP cells as a unique CD4 T cell subpopulation possessing innate effector function as well as autoimmune potential.

  9. MHCクラスIIを介する上皮系細胞によるT細胞免疫制御機構 Competitive

    Offer Organization: 日本学術振興会

    System: 科学研究費補助金 特別研究員奨励費

    2011/04 - 2013/03

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