TOHOKU UNIVERSITY Researchers - Natsuko Kobayashi

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Natsuko Kobayashi

Section

Tohoku University Hospital

Job title

Assistant Professor

researchmap

https://researchmap.jp/natsukokobayashi

J-GLOBAL ID

201901015879738370

e-Rad No.

80535146

Research History 3

2021/04 - Present

Tohoku University Graduate School of Medicine　Department of Psychiatry
2021/04 - Present

Tohoku University Hospital　Psychiatry　assistant professor
2019/04 - 2021/03

Tohoku University School of Medicine　Psychiatric Nursing　assistant professor

Education 2

Tohoku University School of Medicine　department of psychiatry

2012/04 - 2016/09
Tohoku University　medical department

1998/04 - 2004/03

Professional Memberships 4

The International Marce society for Perinatal Mental Health
The Japanese Society for Child and Adolescent Psychiatry
JAPANESE SOCIETY OF PERINATAL MENTAL HEALTH
The Japanise Society of Psychiatry and Neurology

Research Interests 2

perinatal depression
maternal and child health

Research Areas 2

Life sciences / Psychiatry / child psychiatry
Life sciences / Psychiatry / perinatal psychiatry

Papers 74

Posttraumatic Stress Dynamics and 15-Year Persistence in Great East Japan Earthquake Survivors. International-journal

Xue Li, Hitomi Usukura, Yusuke Utsumi, Moe Seto, Atsushi Sakuma, Kazuho Tomimoto, Terufumi Machida, Yumiko Hamaie, Natsuko Kobayashi, Hiroshi Komatsu, Saya Kikuchi, Shinichi Kuriyama, Naoki Nakaya, Atsushi Hozawa, Yasuto Kunii, Hiroaki Tomita

JAMA network open　9　(8)　e2629441　2026/08/03

DOI： 10.1001/jamanetworkopen.2026.29441 　

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IMPORTANCE: Long-term persistence of posttraumatic stress reactions (PTSRs) is a major public health challenge, yet early prognostic markers for decadal outcomes remain poorly characterized. Specifically, the importance of early symptom fluctuations compared with initial cross-sectional severity is not well understood. OBJECTIVE: To determine whether early postdisaster symptom dynamics within 1 year are associated with persistent, clinically meaningful PTSRs 15 years after the 2011 Great East Japan Earthquake (GEJE). DESIGN, SETTING, AND PARTICIPANTS: This 15-year prospective longitudinal cohort study (2011-2025) included residents of Shichigahama, Miyagi, Japan, aged 20 years or older, who experienced disaster-certified housing destruction after the GEJE. EXPOSURES: Early symptom dynamics (2011-2012) based on Impact of Event Scale-Revised (IES-R) scores and classified as (1) high-escalating (IES-R score ≥25 and increasing), (2) high-improving (IES-R score ≥25 and nonincreasing), and (3) nonpersistent early (IES-R score <25 at either wave). MAIN OUTCOMES AND MEASURES: The primary outcomes were persistent, clinically meaningful PTSRs (IES-R score ≥25) at 15 years. Multivariable logistic regression with 40-fold multiple imputation was used to estimate adjusted odds ratios (aORs). RESULTS: Among 1291 participants (685 women [53.1%]; mean [SD] age, 53.9 [16.6] years), group-based trajectory modeling of IES-R scores (2011-2025) identified 5 distinct PTSR patterns. At 15 years, 14.7% of participants (190 participants) had clinically meaningful PTSRs. Symptom escalation was most frequent during the first-to-second year interval compared with all subsequent periods. This trend remained consistent even under stringent escalation criteria (>5-point increase). The high-escalating pattern was the one most associated with 15-year persistence (aOR, 5.31; 95% CI, 3.85-7.32). The prognostic model incorporating early dynamics demonstrated improved discrimination (area under the curve [AUC], 0.756; 95% CI, 0.717-0.763) compared with models using baseline symptom severity alone (AUC, 0.608; 95% CI, 0.600-0.612) or delayed single-point assessments (AUC, 0.726; 95% CI, 0.663-0.738). CONCLUSIONS AND RELEVANCE: In this 15-year cohort study of GEJE survivors, symptom escalation during the first-to-second year interval was identified as the most prevalent pattern and was a factor associated with long-term persistent PTSRs. Because early symptom dynamics offer superior prognostic accuracy compared with single-point assessments, these findings support a serial screening approach during the immediate postdisaster period to optimize risk stratification and early intervention strategies.
Benzodiazepine exposure during early pregnancy and risk of miscarriage: dose-response, half-life classification, and individual agents. International-journal

Tomofumi Ishikawa, Takamasa Sakai, Noriyuki Iwama, Ryo Obara, Kei Morishita, Motohiko Adomi, Tadaharu Kunitoki, Aoi Noda, Mami Ishikuro, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, Masatoshi Saito, Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Archives of women's mental health　29　(3)　2026/05/23

DOI： 10.1007/s00737-026-01720-3 　

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PURPOSE: To evaluate the association between benzodiazepine exposure during early pregnancy and the risk of miscarriage, with a focus on dose-response, half-life, and individual agents. METHODS: This nested case-control study was conducted using a large Japanese administrative database. Cases were defined as pregnancies ending in miscarriage between 2005 and 2023. Controls were randomly selected through risk-set sampling with replacement and matched in a 3:1 ratio. Conditional logistic regression, adjusted for confounders, was used to assess the associations. RESULTS: Overall, 44,118 cases were matched with 132,317 controls, with a mean age of 33.2 years. The prevalence of benzodiazepine exposure was 1.7% and 1.2% among cases and controls, respectively. Etizolam (0.3%) had the highest prevalence, followed by alprazolam (0.3%) and brotizolam (0.2%) in both groups. Adjusted odds ratio (OR) for benzodiazepine exposure during early pregnancy was 1.241 (95% confidence interval: 1.136-1.357). Adjusted ORs for high-dose (1.212 [1.050-1.400]) and medium-dose (1.189 [1.037-1.363]) exposure were numerically higher than that for low-dose exposure (1.111 [0.934-1.322]). Adjusted OR for long-acting benzodiazepines (1.308 [1.124-1.522]) was numerically higher than those for intermediate- (1.132 [0.999-1.284]) and short-acting (1.157 [1.030-1.300]) agents. Adjusted ORs for etizolam, alprazolam, and brotizolam were 0.929 (0.782-1.103), 0.853 (0.707-1.030), and 1.454 (1.180-1.791), respectively. CONCLUSIONS: Benzodiazepine exposure during early pregnancy was modestly associated with an increased risk of miscarriage. Although associations tended to be stronger with higher dose levels and longer half-life categories, estimates across subgroups lacked precision and should be interpreted with caution.
東北地域における性別違和診療の現状と課題

長岡敦子, 小林奈津子, 菊地紗耶, 佐藤祐太朗, 富田博秋

精神神経学雑誌　127　(5)　351-351　2025/05
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東北大学病院ジェンダー医療センター開設に伴う精神科における性別違和診療の現状と課題

小林奈津子, 菊地紗耶, 佐藤祐太朗, 富田博秋

日本GI(性別不合)学会雑誌　17　(1)　131-134　2024/12
Publisher: 日本GI(性別不合)学会
ISSN： 2759-6230
不登校と同時期に性別違和症状が出現した思春期の一例

菊地紗耶, 小林奈津子, 佐藤祐太朗, 富田博秋

日本GI(性別不合)学会雑誌　17　(1)　306-307　2024/12
Publisher: 日本GI(性別不合)学会
ISSN： 2759-6230
東北大学病院ジェンダー医療センター開設に伴う,精神科における性別違和診療の現状と課題

小林奈津子, 佐藤祐太朗, 菊地紗耶, 富田博秋

日本GI(性別不合)学会雑誌　17　(1)　312-312　2024/12
Publisher: 日本GI(性別不合)学会
ISSN： 2759-6230
Association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. International-journal

Tomofumi Ishikawa, Takamasa Sakai, Noriyuki Iwama, Ryo Obara, Kei Morishita, Motohiko Adomi, Aoi Noda, Mami Ishikuro, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, Masatoshi Saito, Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Acta psychiatrica Scandinavica　2024/09/05

DOI： 10.1111/acps.13755 　

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OBJECTIVE: To evaluate the association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. MATERIAL AND METHODS: This nested case-control study used a large Japanese administrative database. Pregnancy onset and outcomes were estimated using previously reported algorithms, classifying cases as women becoming pregnant between 2013 and 2022 and ending in a miscarriage. Controls were randomly selected from the entire pregnancy cohort by risk-set sampling with replacement and were individually matched to the cases (3:1). The association between exposure to atypical antipsychotics and risk of miscarriage was assessed using conditional logistic regression adjusted for confounders. The association between benzodiazepine exposure and the risk of miscarriage was assessed as a positive control. RESULTS: In the cohort, 44,118 patients were matched with 132,317 controls. The mean ages (standard deviations) of the case and control groups were 33.3 (5.7) and 33.2 (5.5) years, respectively. The prevalence of atypical antipsychotics was 0.5% in both groups. Aripiprazole is an individual antipsychotic with the highest prescription prevalence. The adjusted odds ratios (aOR) for miscarriage were 0.966 (95% confidence interval [CI], 0.796-1.173) for atypical antipsychotics and 0.998 (0.784-1.269) for aripiprazole. A higher aOR (1.431, 95% CI 1.303-1.573) suggested an association with benzodiazepines. A sensitivity analysis that limited the population to women diagnosed with schizophrenia alone did not suggest an association between atypical antipsychotics and the risk of miscarriage. CONCLUSIONS: The results of this study do not suggest an association between exposure to atypical antipsychotics during pregnancy and the risk of miscarriage.
【-身体疾患の患者・家族のこころを支える-コンサルテーション・リエゾン精神医学】周産期医療におけるコンサルテーション・リエゾン精神医学プレコンセプションケアから育児支援まで

菊地紗耶, 小林奈津子, 富田博秋

精神医学　66　(9)　1165-1171　2024/09
Publisher: (株)医学書院
ISSN： 0488-1281

eISSN： 1882-126X
【こんなときどうする?いまさら聞けないうつ病治療における薬物療法-虎の巻-】産後うつ病における薬物療法の考え方

菊地紗耶, 小林奈津子, 富田博秋

精神科治療学　39　(8)　881-886　2024/08
Publisher: (株)星和書店
ISSN： 0912-1862
【周産期メンタルヘルスを深掘り!】精神疾患合併妊産婦の対応双極性障害(双極症)

菊地紗耶, 小林奈津子, 富田博秋

産科と婦人科　91　(6)　665-669　2024/06
Publisher: (株)診断と治療社
ISSN： 0386-9792
Response to ‘Potential role of anti‐inflammatory cytokines in postpartum depression: Considerations for future research and improvement’

Chiaki T. Ono, Zhiqian Yu, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita

Psychiatry and Clinical Neurosciences　78　(5)　335-336　2024/03/20
Publisher: Wiley
DOI： 10.1111/pcn.13660 　

ISSN： 1323-1316

eISSN： 1440-1819
【よくわかる! 精神疾患対応これ1冊-内科医と精神科医の連携のために】(第2部)精神科との連携が特に必要な領域児童虐待への対応

菊地紗耶, 小林奈津子, 富田博秋

診断と治療　112　(Suppl.)　61-65　2024/03
Publisher: (株)診断と治療社
ISSN： 0370-999X
Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory. International-journal

Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Natsuko Kobayashi, Saya Kikuchi, Xue Li, Aoi Noda, Keiko Murakami, Gen Tamiya, Junichi Sugawara, Hiroaki Tomita, Shinichi Kuriyama

Depression and anxiety　2024　6622666-6622666　2024

DOI： 10.1155/2024/6622666 　

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This study is aimed at revealing the risk factors, prognosis, influence on offspring, and genetic architecture of perinatal depression (PD) classified based on the depressive symptom trajectory. Pregnant women with no history of major depressive disorder (MDD) were recruited and followed up with their offspring from 1 to 5 years postpartum. Using four self-report questionnaires in the perinatal period, PD was classified into four subtypes: pregnancy, early postpartum, late postpartum, and chronic PD. Risk factors, depressive symptom trajectory from 1 to 5 years postpartum, and child behavior problems were compared among the four PD subtypes. Genome-wide association studies (GWASs) were conducted for each subtype. The relationships between the PD subtypes and polygenic risk scores (PRS) for MDD, a psychiatric disorder, and premenstrual syndrome (PMS), a hormonal disorder, were examined. Among 12,338 participants, 1,145 (9.3%) developed pregnancy PD, 856 (6.9%) developed early postpartum PD, 382 (3.1%) developed late postpartum PD, and 1,048 (8.5%) developed chronic PD. Depressive symptoms decreased to 61.0%-73.3% in the 5 years postpartum. The relationship between risk factors and PD varied based on the PD subtype. Additionally, chronic PD increased the risk of child behavior problems by 2- to 3-fold. The GWASs uncovered five significant variants in different loci depending on PD subtypes, suggesting a subtype-specific genetic architecture. The PRS for MDD was related to pregnancy, early postpartum, and chronic PD, while that for PMS was related to late postpartum PD. It was concluded that PD is heterogeneous depending on the depressive symptom trajectory. Thus, specific prevention and treatment strategies are needed.
総合病院における産科と精神科の連携:妊産婦のメンタルヘルスと精神病患者の出産のために周産期における精神科薬物療法と共同意思決定東北大学病院における実践報告

菊地紗耶, 小林奈津子, 木村涼子, 岩渕賢嗣, 富田博秋

総合病院精神医学　35　(Suppl.)　S-97　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
妊娠中の睡眠に関する主観的評価の変化と産後うつ病リスクの関連性

木村涼子, 菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 富田博秋

総合病院精神医学　35　(Suppl.)　S-162　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
ペリネイタルロスに伴うメンタルヘルス上の問題と心理社会的要因に関する後方視調査

岩渕賢嗣, 菊地紗耶, 小林奈津子, 木村涼子, 富田博秋

総合病院精神医学　35　(Suppl.)　S-194　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
東日本大震災被災地域の子どものメンタルヘルスと学校における集団活動の関連について

松木佑, 吉田弘和, 北川佳奈, 遠藤愛子, 小林奈津子, 菊地紗耶, 本多奈美, 大塚達以, 富田博秋

日本児童青年精神医学会総会抄録集　64回　O17-3　2023/11
Publisher: (一社)日本児童青年精神医学会
薬剤性イレウスをきたした治療抵抗性双極I型障害に対し維持ECTが有効であった一例

小番健矢, 小松浩, 小林奈津子, 冨本和歩, 佐久間篤, 富田博秋

総合病院精神医学　35　(Suppl.)　S-254　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
向精神薬服用中の母乳育児の実態と児への影響授乳プランシートの結果から

菊地紗耶, 小林奈津子, 小原拓, 岩渕理子, 齋藤昌利, 木村涼子, 岩渕賢嗣, 富田博秋

日本周産期メンタルヘルス学会学術集会抄録集　19回　114-114　2023/10
Publisher: 日本周産期メンタルヘルス学会
産後早期の睡眠に関する主観的評価の変化と産後うつ病リスクの関連性

木村涼子, 菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 富田博秋

日本周産期メンタルヘルス学会学術集会抄録集　19回　112-112　2023/10
Publisher: 日本周産期メンタルヘルス学会
向精神薬服用中の母乳育児の実態と児への影響授乳プランシートの結果から

菊地紗耶, 小林奈津子, 小原拓, 岩渕理子, 齋藤昌利, 木村涼子, 岩渕賢嗣, 富田博秋

日本周産期メンタルヘルス学会学術集会抄録集　19回　114-114　2023/10
Publisher: 日本周産期メンタルヘルス学会
精神科医にどのように性別不合(Gender Incongruence)医療に参入してもらうか東北地方における性別不合医療の現状と解決すべき課題

富田博秋, 佐藤祐太朗, 小林奈津子, 菊地紗耶, 林昌伸, 黒沢是之, 渡邉善, 志賀尚美, 立花眞仁, 山下慎一, 伊藤明宏, 島田宗昭, 今井啓道

精神神経学雑誌　(2023特別号)　S457-S457　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
妊婦における精神神経用剤服薬および心理的苦痛の有無と2歳時点の児の行動特性との関連

高橋一平, 小原拓, 菊地紗耶, 小林奈津子, 小原竜, 野田あおい, 上野史彦, 大沼ともみ, 村上慶子, 石黒真美, 富田博秋, 栗山進一

精神神経学雑誌　(2023特別号)　S584-S584　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
【プレコンセプションケアからみた精神医学-妊娠・出産に向けたメンタルヘルスの新たな潮流-】うつ病・不安症のプレコンセプションケア

菊地紗耶, 小林奈津子, 木村涼子, 富田博秋

精神科治療学　38　(5)　549-554　2023/05
Publisher: (株)星和書店
ISSN： 0912-1862
【こんな時どうする? 5W2Hで学ぶ抗うつ薬の使い方】5W2Hで学ぶ抗うつ薬の使い方妊娠・授乳期

菊地紗耶, 小林奈津子, 木村涼子, 富田博秋

薬事　65　(5)　903-907　2023/04
Publisher: (株)じほう
ISSN： 0016-5980
母親における出産前後の社会的孤立と児の発達との関連三世代コホート調査

村上慶子, 野田あおい, 石黒真美, 小原拓, 上野史彦, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一

日本衛生学雑誌　78　(Suppl.)　S173-S173　2023/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082

eISSN： 1882-6482
母親の社会的孤立と児の問題行動の関連東北メディカル・メガバンク計画三世代コホート調査

村上慶子, 石黒真美, 小原拓, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 高橋一平, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 菊谷昌浩, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　92-92　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Journal of affective disorders　320　461-467　2023/01/01

DOI： 10.1016/j.jad.2022.09.139 　

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BACKGROUND: Natural disasters can have serious mental health consequences. We aimed to examine the long-term effects of the 2011 Great East Japan Earthquake (GEJE) on postpartum depressive symptoms (PDS). METHODS: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women in Miyagi Prefecture from 2013 to 2016. Data from 11,403 participants were used in this study. Women were asked about their traumatic experiences of the GEJE with questions addressing threat, witness, and loss. PDS were defined as Edinburgh Postnatal Depression Scale score ≥9 at 1 month after delivery. Multiple logistic regression analyses were conducted to examine the associations of different traumatic experiences of the GEJE and number of traumatic experiences with PDS, after adjustment for age, parity, feelings toward pregnancy, education, income, social isolation, house damage caused by the GEJE, and survey year. RESULTS: About two-fifths of women had at least one traumatic experience of the GEJE. The prevalence of PDS at 1 month after delivery was 13.3 %. Life-threatening experience and witnessing another person's actual or threatened death were associated with PDS: the odds ratios (ORs) were 1.40 (95 % confidence interval [CI], 1.24-1.59) and 1.28 (95 % CI, 1.08-1.53), respectively. Loss of close person was not associated with PDS: the OR was 1.13 (95 % CI, 0.99-1.30). Larger number of traumatic experiences of the GEJE was associated with increased risk of PDS (p for trend <0.001). LIMITATIONS: PDS was self-reported. CONCLUSIONS: Traumatic experiences of the GEJE prior to pregnancy were associated with increased risks of PDS.
Plasma metabolic disturbances during pregnancy and postpartum in women with depression. International-journal

Zhiqian Yu, Naomi Matsukawa, Daisuke Saigusa, Ikuko N Motoike, Chiaki Ono, Yasunobu Okamura, Tomomi Onuma, Yuta Takahashi, Mai Sakai, Hisaaki Kudo, Taku Obara, Keiko Murakami, Matusyuki Shirota, Saya Kikuchi, Natsuko Kobayashi, Yoshie Kikuchi, Junichi Sugawara, Naoko Minegishi, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Seizo Koshiba, Hiroaki Tomita

iScience　25　(12)　105666-105666　2022/12/22

DOI： 10.1016/j.isci.2022.105666 　

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Examining plasma metabolic profiling during pregnancy and postpartum could help clinicians understand the risk factors for postpartum depression (PPD) development. This analysis targeted paired plasma metabolites in mid-late gestational and 1 month postpartum periods in women with (n = 209) or without (n = 222) PPD. Gas chromatogram-mass spectrometry was used to analyze plasma metabolites at these two time points. Among the 170 objected plasma metabolites, principal component analysis distinguished pregnancy and postpartum metabolites but failed to discriminate women with and without PPD. Compared to women without PPD, those with PPD exhibited 37 metabolites with disparate changes during pregnancy and the 1-month postpartum period and an enriched citrate cycle. Machine learning and multivariate statistical analysis identified two or three compounds that could be potential biomarkers for PPD prediction during pregnancy. Our findings suggest metabolic disturbances in women with depression and may help to elucidate metabolic processes associated with PPD development.
Social isolation and insomnia among pregnant women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Sleep health　8　(6)　714-720　2022/12

DOI： 10.1016/j.sleh.2022.08.007 　

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OBJECTIVES: To estimate the prevalence of insomnia and examine the association between social isolation and insomnia among pregnant women. METHODS: This cross-sectional study was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Pregnant women were recruited at obstetric clinics and hospitals in Miyagi Prefecture, Japan. We analyzed 17,586 women who completed the questionnaires and were allowed to transcribe medical records. Insomnia was defined as the Athens Insomnia Scale score of ≥6. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores <12), and its subscales were used to assess marginal family ties and marginal friendship ties. Multiple logistic regression analyses were conducted to examine the association between social isolation and insomnia during pregnancy, adjusting for age, parity, prepregnancy body mass index, feelings toward pregnancy, education, income, work status, morning sickness, and psychological distress. Multiple logistic regression analyses were also conducted for marginal family ties and marginal friendship ties. RESULTS: The prevalence of insomnia in the second trimester was 37.3%. Women who were socially isolated were more likely to have insomnia than women who were socially integrated: the multivariate-adjusted odds ratio (OR) was 1.26 (95% confidence interval [CI], 1.16-1.36). Marginal family ties and marginal friendship ties were also associated with increased risks of insomnia: the multivariate-adjusted ORs were 1.40 (95% CI, 1.25-1.56) and 1.15 (95% CI, 1.07-1.24), respectively. CONCLUSIONS: Social isolation from family and friends was associated with increased risks of insomnia among pregnant women.
Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Ippei Takahashi, Keiko Murakami, Mika Kobayashi, Saya Kikuchi, Ayaka Igarashi, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama

BMC psychiatry　22　(1)　693-693　2022/11/11

DOI： 10.1186/s12888-022-04330-2 　

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BACKGROUND: Childcare facilities are a factor that lowers the established association of mother's postnatal psychiatric symptoms with children's behavioral problems. However, no studies have considered the prenatal psychiatric symptoms yet. This study examined whether the use of childcare facilities moderates the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years. METHODS: The present study was based on the data from 23,130 mother-child pairs participating in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. K6 was used to classify maternal psychological distress in early pregnancy and at two years postpartum into four categories: none in both prenatal and postnatal periods (none), only the prenatal period (prenatal only); only the postnatal period (postnatal only); both prenatal and postnatal periods (both). The children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) aged four years. The clinical range of the externalizing, internalizing, and total problem scales of the CBCL was defined as having behavioral problems. To examine whether availing childcare facilities moderates the association between maternal psychological distress and children's behavioral problems, we conducted a stratified analysis based on the use of childcare facilities or not, at two years of age. The interaction term between maternal psychological distress and use of childcare facilities was included as a covariate in the multivariate logistic regression analysis to confirm the p-value for the interaction. RESULTS: The prevalence of the clinical ranges of externalizing problems, internalizing problems, and clinical range of total problems were 13.7%, 15.4%, and 5.8%, respectively. The association of maternal psychological distress with a high risk of children's behavioral problems was significant; however, the association between prenatal only psychological distress and externalizing problems in the group that did not use childcare facilities was not significant. Interactions between the use of childcare facilities and maternal psychological distress on behavioral problems in children were not significant. CONCLUSIONS: Use of childcare facilities did not moderate the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years.
Social isolation and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Archives of Women's Mental Health　25　(6)　1079-1086　2022/09/17
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00737-022-01266-0 　

ISSN： 1434-1816

eISSN： 1435-1102

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Although there is substantial information about the effects of social relationships on mental health, their effects on postnatal bonding remain unclear. We aimed to examine the association between social isolation and postnatal bonding disorder. We analyzed data from 17,999 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. An abbreviated version of the Lubben Social Network Scale was used to assess social isolation in the second trimester of pregnancy, and its subscales were used to assess marginal family ties and marginal friendship ties. Bonding disorder was defined as a Mother-to-Infant Bonding Scale score of ≥ 5 1 month after delivery. Multiple logistic regression analyses were conducted to examine the association between social isolation and postnatal bonding disorder after adjusting for age at delivery, parity, feelings towards pregnancy, psychological distress during pregnancy, and household income. Analyses stratified by postnatal depressive symptoms (PDS) were also conducted. Social isolation was associated with postnatal bonding disorder: the odds ratio (OR) was 1.55 (95% confidence interval [CI], 1.41-1.71). Marginal family ties and friendship ties were associated with postnatal bonding disorder: the ORs were 1.40 (95% CI, 1.23-1.60) and 1.44 (95% CI, 1.32-1.57), respectively. Marginal family ties were associated with postnatal bonding disorder only among women without PDS: the ORs were 1.30 (95% CI, 1.10-1.55) among women without PDS and 1.13 (95% CI, 0.91-1.40) among women with PDS. Social isolation during pregnancy was associated with an increased risk of postnatal bonding disorder.
ウエラブルデバイスおよび睡眠ログにより測定した産後早期の睡眠特徴とメンタルヘルスとの関連

菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 木村涼子, 富田博秋

精神神経学雑誌　124　(4付録)　S-378　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
【妊娠・出産をめぐる最近の話題】妊娠中・産後の精神状態を紐解く

菊地紗耶, 小林奈津子, 富田博秋

保健の科学　64　(4)　242-246　2022/04
Publisher: (株)杏林書院
ISSN： 0018-3342
ウエラブルデバイスおよび睡眠ログにより測定した産後早期の睡眠特徴とメンタルヘルスとの関連

菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 木村涼子, 富田博秋

精神神経学雑誌　124　(4付録)　S-378　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災被災地域の子どもの睡眠状況の変化とメンタルヘルスとの関連について

松木佑, 吉田弘和, 北川佳奈, 遠藤愛子, 小林奈津子, 菊地紗耶, 本多奈美, 大塚達以, 富田博秋

日本児童青年精神医学会総会抄録集　62回　O-67　2021/11
Publisher: (一社)日本児童青年精神医学会
【児童虐待を予防する-産婦人科医,小児科医,精神科医のコラボレーション-】虐待予防のために精神科医ができること周産期メンタルケア外来の実践から

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神神経学雑誌　123　(10)　640-646　2021/10
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Corrigendum: The delivery of a placenta/fetus with high gonadal steroid production contributes to postpartum depressive symptoms. International-journal

Saya Kikuchi, Natsuko Kobayashi, Zen Watanabe, Chiaki Ono, Takashi Takeda, Hidekazu Nishigori, Nobuo Yaegashi, Takahiro Arima, Kunihiko Nakai, Hiroaki Tomita

Depression and anxiety　38　(10)　1100-1100　2021/10

DOI： 10.1002/da.23216 　
One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Saya Kikuchi, Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Natsuko Kobayashi, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Hiroaki Tomita

Journal of affective disorders　295　632-638　2021/09/04

DOI： 10.1016/j.jad.2021.08.118 　

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BACKGROUND: Trajectories of postpartum depressive symptoms up to 1 year after childbirth and the related risk factors remain unclear. Accordingly, this study aimed to examine the 1-year trajectories of postpartum depressive symptoms and their associated risk factors. METHODS: A total of 22,493 pregnant women were recruited between July 2013 and September 2016 in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. Among them, 11,668 women with no missing data were included in the analyses. Depressive symptoms were assessed at 1 month and 1 year postpartum using the Edinburgh Postnatal Depression Scale. Multinominal logistic regression analysis was conducted after adjusting for covariates. RESULTS: The prevalence of depression was 13.9% at 1 month and 12.9% at 1 year postpartum. We identified four depression trajectories, i.e., "persistent (depressed throughout the 1 year postpartum)" (6.0%), "recovered (depressed at 1 month postpartum and recovered within a year)" (7.9%), "late-onset (became depressed after 1 month postpartum)" (6.8%), and "resilient (not depressed throughout 1 year postpartum)" (79.2%). Psychological distress during pregnancy was significantly associated with all trajectories (persistent: odds ratio [OR]=10.24, 95% confidence interval (CI)=8.40-12.48; recovered: OR=3.78, 95%CI=3.28-4.36; and late-onset: OR=3.96, 95%CI=3.40-4.62). LIMITATIONS: Postpartum depression was evaluated only by a self-administered questionnaire and the dropout rate was not neglectable. CONCLUSIONS: This study highlighted the high prevalence of depressive symptoms at 1 year postpartum and found that half of the depressive symptoms at 1 year were late-onset. The findings suggest the necessity of long-term follow-up (up to 1 year) for perinatal mental health.
【母と子のメンタルヘルスと心理社会的支援多職種連携で妊産婦を支える】知識編各職種の立場から出産前後の性ホルモン変化と産後うつとの関連精神科医師の立場から

菊地紗耶, 小林奈津子, 富田博秋

ペリネイタルケア　40　(9)　856-860　2021/09
Publisher: (株)メディカ出版
ISSN： 0910-8718
【日本の周産期メンタルヘルス事情update】産科医のための周産期メンタルヘルスケア入門

菊地紗耶, 小林奈津子, 木村涼子, 富田博秋

産婦人科の実際　70　(6)　635-640　2021/06
Publisher: 金原出版(株)
ISSN： 0558-4728
【双極性障害診療を極める】妊産婦双極性障害における治療継続の方法・気をつけること

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神科治療学　36　(5)　569-574　2021/05
Publisher: (株)星和書店
ISSN： 0912-1862
The delivery of a placenta/fetus with high gonadal steroid production contributes to postpartum depressive symptoms. International-journal

Saya Kikuchi, Natsuko Kobayashi, Zen Watanabe, Chiaki Ono, Takashi Takeda, Hidekazu Nishigori, Nobuo Yaegashi, Takahiro Arima, Kunihiko Nakai, Hiroaki Tomita

Depression and anxiety　38　(4)　422-430　2021/04

DOI： 10.1002/da.23134 　

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BACKGROUND: A correlation between gonadal steroids and depressive symptoms during the perinatal period has long been suggested; however, the underlying mechanism for this relationship remains unclear. METHODS: This study was designed to examine the correlation between gonadal steroid concentrations of umbilical cord blood and postpartum depressive symptoms as well as longitudinal alterations in maternal plasma gonadal steroid concentrations among 204 perinatal women. The levels of postpartum depressive state at 1 month postpartum were evaluated using the Edinburgh Postnatal Depression Scale. RESULTS: Umbilical progesterone, estradiol, and testosterone levels were significantly higher in infants delivered by depressed mothers (870.7 ± 281.7 ng/ml, 8607.7 ± 4354.6 pg/ml, and 2.5 ± 0.9 ng/ml, respectively) than those delivered by nondepressed mothers (741.3 ± 324.0 ng/ml, 5221.9 ± 3416.3 pg/ml, and 2.1 ± 0.6 ng/ml, p < .01, p < .05, and p < .05, respectively). Postpartum plasma progesterone levels of depressed mothers (3.5 ± 3.1 ng/ml) measured in the early postpartum period were significantly lower than those of nondepressed mothers (9.1 ± 9.7 ng/ml, p < .01). The decrease in progesterone from mid-pregnancy to the early postpartum period was significantly higher in depressed mothers than in nondepressed mothers. Subgroup analyses specific to primiparas or multiparas indicated that a significant drop of progesterone was seen only in primiparas. CONCLUSION: The current study suggests that the delivery of a placenta/fetus with high gonadal steroid production may cause a wider range of fluctuations in maternal plasma gonadal steroid concentrations, which may be concurrent with postpartum depressive symptoms.
Experiences of perinatal women and public healthcare providers in a community affected by the great east Japan earthquake and tsunami: Concerns that must be considered for the mental healthcare of perinatal women in postdisaster settings

Natsuko Kobayashi, Harumi Nemoto, Moe Seto, Shosuke Sato, Saya Kikuchi, Nami Honda, Tomomi Suzuki, Kineko Sato, Junichi Sugawara, Kiyoshi Ito, Ryoma Kayano, Norio Ozaki, Charles W. Beadling, Ilan Kelman, Fumihiko Imamura, Hiroo Matsuoka, Hiroaki Tomita

International Journal of Disaster Risk Reduction　51　2020/12

DOI： 10.1016/j.ijdrr.2020.101767 　

ISSN： 2212-4209
児童虐待を予防する-産婦人科医、小児科医、精神科医のコラボレーション- 虐待予防のために精神科医ができること周産期メンタルケア外来の実践から

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神神経学雑誌　(2020特別号)　S487-S487　2020/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
周産期メンタルヘルスの最前線産後うつ病の特徴と治療

小林奈津子, 菊地紗耶, 本多奈美, 富田博秋

精神神経学雑誌　(2020特別号)　S538-S538　2020/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
周産期の統合失調症に対する抗精神病薬投与と代謝性合併症

小林奈津子, 菊地紗耶, 齋藤昌利, 本多奈美, 富田博秋

精神神経学雑誌　(2020特別号)　S441-S441　2020/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
産後うつ病の予測と予防のための血漿サイトカインレベルの検証

兪志前, 小野千晶, 小原拓, 菊地沙耶, 小林奈津子, 菅原準一, 栗山進一, 山本雅之, 八重樫伸生, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020/08
Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
【妊娠・出産と精神科臨床アップデート】授乳期の精神科薬物療法

菊地紗耶, 小林奈津子, 小原拓, 本多奈美, 富田博秋

臨床精神医学　49　(7)　907-915　2020/07
Publisher: (株)アークメディア
ISSN： 0300-032X
周産期におけるメンタルヘルスのスクリーニングと連携のポイント

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

女性心身医学　24　(3)　244-248　2020/03
Publisher: (一社)日本女性心身医学会
ISSN： 1345-2894
【さまざまな背景のある患者にどうする?-リアルワールドの薬物療法】妊娠授乳期の精神科薬物療法

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

臨床精神薬理　22　(12)　1205-1212　2019/12
Publisher: (株)星和書店
ISSN： 1343-3474
最新の知見に基づいた周産期における薬物治療のあり方とは何か産後うつ病の薬物療法期待される抗うつ薬とは

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

総合病院精神医学　31　(Suppl.)　S-104　2019/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
Post-disaster mental health and psychosocial support in the areas affected by the Great East Japan Earthquake: a qualitative study. International-journal

Moe Seto, Harumi Nemoto, Natsuko Kobayashi, Saya Kikuchi, Nami Honda, Yoshiharu Kim, Ilan Kelman, Hiroaki Tomita

BMC psychiatry　19　(1)　261-261　2019/08/27

DOI： 10.1186/s12888-019-2243-z 　

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BACKGROUND: Few studies exploring the actual practices implemented for long-term mental health and psychosocial support after a natural disaster have been published. This study aimed to reveal (1) the types of activities that were actually provided as mental health and psychosocial support (MHPSS) in the long-term phase after the Great East Japan Earthquake (GEJE) and (2) the problems that must be addressed to provide post-disaster MHPSS activities. METHODS: An open-ended questionnaire was sent to organizations in the Iwate, Miyagi and Fukushima prefectures that were potentially involved in providing MHPSS to communities affected by the GEJE. The organizations were asked to describe their activities and the problems that needed to be addressed to provide these support activities. The collected statements were analysed using content analysis with NVivo11. RESULTS: The support activities conducted to provide MHPSS in the long-term phase after the catastrophe were diverse and classified into 7 major categories, namely, (1) one-on-one support for individuals in need of assistance, (2) support for collective activities, (3) support around living conditions and income, (4) increasing public awareness about mental health, (5) human resource development to improve response capabilities for MHPSS, (6) support for MHPSS providers, and (7) facilitating collaborations among the MHPSS activities provided to affected communities. Problems with human resources and funding were the most frequently mentioned concerns among the organizations participating in the survey. CONCLUSIONS: The establishment of systems to collect and share sufficient and relevant knowledge and to coordinate organizations for long-term post-disaster postventions would be desirable.
周産期における統合失調症患者の薬物療法と再発に関する後方視的研究

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神神経学雑誌　(2019特別号)　S443-S443　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災における周産期の女性と地域母子保健ヘルスケア従事者の経験に関する質的研究

小林奈津子, 菊地紗耶, 本多奈美, 富田博秋

精神神経学雑誌　(2019特別号)　S650-S650　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
さまざまな精神神経疾患の妊娠・出産・授乳への対応気分障害合併妊産婦に対する妊娠・出産・授乳への対応

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神神経学雑誌　(2019特別号)　S709-S709　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災被災地における中長期的な心理社会的支援の実態と課題

瀬戸萌, 富田博秋, 根本晴美, 小林奈津子, 金吉晴

精神神経学雑誌　(2019特別号)　S631-S631　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
【周産期のメンタルヘルスケア-早期発見と支援】周産期の薬物療法、精神療法

菊地紗耶, 小林奈津子, 本多奈美

日本医事新報　(4924)　34-37　2018/09
Publisher: (株)日本医事新報社
ISSN： 0385-9215
- Peer-reviewed

120　(1)　32-38　2018
Publisher:
ISSN： 0033-2658
妊産褥婦のこころを支えたい〜今、精神医療に求められる周産期リエゾン活動〜心理支援に特化した助産師外来との連携助産師によるメンタルヘルスケアの充実に向けて

菊地紗耶, 小林奈津子, 本多奈美, 松岡洋夫

精神神経学雑誌　(2017特別号)　S442-S442　2017/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
周産期メンタルケア外来（精神科設置）

菊地紗耶, 小林奈津子, 本多奈美, 松岡洋夫

精神科治療学　32　723-726　2017
産科的問題が生じた際の妊産婦・家族の心理的問題とその支援 Peer-reviewed

菊地紗耶, 小林奈津子, 本多奈美, 松岡洋夫

日本周産期メンタルヘルス学会会誌　3　11-15　2017
- Peer-reviewed

119　819-826　2017
Post-traumatic growth of children affected by the Great East Japan Earthquake and their attitudes to memorial services and media coverage Peer-reviewed

Hirokazu Yoshida, Natsuko Kobayashi, Nami Honda, Hiroo Matsuoka, Takuhiro Yamaguchi, Hiroaki Homma, Hiroaki Tomita

PSYCHIATRY AND CLINICAL NEUROSCIENCES　70　(5)　193-201　2016/05

DOI： 10.1111/pcn.12379 　

ISSN： 1323-1316

eISSN： 1440-1819
地域で支える母子と家族のメンタルヘルス

菊地紗耶, 佐野ゆり, 小澤千恵, 平野秀人, 小林奈津子, 本多奈美, 松岡洋夫

予防精神医学　1　102-113　2016
- Peer-reviewed

57　(5)　783-807　2016
Publisher:
ISSN： 0289-0968
Disaster preparedness for the psychological well-being of perinatal women: Surveys of mothers and public healthcare providers in a community affected by the Great East Japan Earthquake and Tsunami

Natsuko Kobayashi

Tohoku University　2016
災害時の妊産褥婦の心理的反応と母子保健・支援活動

小林奈津子, 根本晴美, 佐藤翔輔, 菊地紗耶, 本多奈美, 松岡洋夫, 富田博秋

第12回日本周産期メンタルヘルス学会学術集会　2015/10
周産期医療とリエゾン精神医学

菊地紗耶, 小林奈津子, 本多奈美, 松岡洋夫

精神医学　57　195-202　2015
周産期に新たに生じる精神科的問題への介入精神科医に求められる役割

菊地紗耶, 小林奈津子, 本多奈美, 松岡洋夫

総合病院精神医学　27　(3)　212-218　2015
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872

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周産期におけるメンタルヘルスは、精神科医だけでなく、助産師、看護師などが関わるため、多職種連携が不可欠である。精神科医が妊産婦への適切な診断、治療選択、心理教育を行い、育児支援体制に配慮することと、多職種連携に積極的に関与すること、スタッフに精神疾患の知識や精神疾患を有する妊産婦への対応方法などを教えることも重要な役割である。周産期に新たに出現する精神医学的問題への介入について、周産期鬱病を中心に、その危険因子、危険因子を有するいわゆるハイリスク妊産婦の同定、ハイリスク妊産婦への介入について述べた。
地域母子保健と精神科医療の連携

菊地紗耶, 小林奈津子, 本多奈美

日本周産期メンタルヘルス研究会会誌　1　3-8　2014
A child case of Gardner-Diamond syndrome triggered by the Tohoku-Pacific Ocean Earthquake Peer-reviewed

Mei Nasu, Natsuko Kobayashi, Setsuya Aiba

EUROPEAN JOURNAL OF DERMATOLOGY　23　(3)　425-427　2013/05

DOI： 10.1684/ejd.2013.2047 　

ISSN： 1167-1122
当院での周産期の薬物療法について

小林奈津子, 菊地紗耶, 松岡洋夫

精神神経学雑誌　(2012特別)　S-449　2012/05
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
幼児期から学童期前期の広汎性発達障害に伴う攻撃性への心理社会的介入に関する臨床的研究

菊地紗耶, 小林奈津子, 本多奈美, 小野善郎

日本児童青年精神医学会総会抄録集　50回　298-298　2009/09
Publisher: (一社)日本児童青年精神医学会

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Misc. 11

母親の妊娠中と産後の心理的苦痛と4歳時点における児の発達との関連三世代コホート調査

高橋一平, 小原拓, 菊地紗耶, 小林美佳, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 小林奈津子, 濱田裕貴, 岩間憲之, 齋藤昌利, 菅原準一, 富田博秋, 呉繁夫, 八重樫伸生, 栗山進一

DOHaD研究　11　(3)　29-29　2023/08
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
東日本大震災被災地域の子どもの睡眠状況の変化とメンタルヘルスとの関連について

松木佑, 吉田弘和, 北川佳奈, 遠藤愛子, 小林奈津子, 菊地紗耶, 本多奈美, 大塚達以, 富田博秋, 富田博秋

日本児童青年精神医学会総会抄録(Web)　62nd　2021
躁状態で発症し,オランザピンが奏効した産褥精神病の1例

小野寺文一郎, 田坂有香, 大塚達以, 菊地紗耶, 小林奈津子, 小林奈津子, 富田博秋, 富田博秋

精神神経学雑誌　123　(6)　2021

ISSN： 0033-2658
【周産期メンタルヘルスの今】東北メディカル・メガバンク事業出生コホートを起点とした産後うつ病研究

菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 村上慶子, 小原拓, 長神風二, 栗山進一, 富田博秋

精神医学　62　(9)　1245-1251　2020/09
Publisher: (株)医学書院
ISSN： 0488-1281

eISSN： 1882-126X
産後うつ病の予測と予防のための血漿サイトカインレベルの検証

兪志前, 小野千晶, 小原拓, 菊地沙耶, 小林奈津子, 菅原準一, 栗山進一, 山本雅之, 八重樫伸生, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020/08
Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
産後1年までのうつ症状の推移と心理社会的要因との関連:三世代コホート調査

菊地紗耶, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大柳元, 大柳元, 小原拓, 小原拓, 小原拓, 小林奈津子, 小林奈津子, 菅原準一, 富田博秋, 富田博秋, 栗山進一, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　30th　2020
重症悪阻を呈し精神科紹介になった妊産婦における精神科的介入と心理的要因について

小林奈津子, 菊地紗耶, 本多奈美, 松岡洋夫

精神神経学雑誌　(2015特別)　S543-S543　2015/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
虚無妄想を認め産褥精神病が疑われた1例

橋田かなえ, 佐久間篤, 桂雅宏, 本多奈美, 小林奈津子, 菊地紗耶, 松岡洋夫

精神神経学雑誌　117　(5)　369-369　2015/05
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災被災者の喪失と悲嘆のプロファイル

小林奈津子, 新宮古都美, 庄子朋香, 北田友子, 中谷直樹, 中村智洋, 土屋菜歩, 吉田弘和, 菊地紗耶, 本多奈美, 松岡洋夫, 中島聡美, 寳澤篤, 辻一郎, 富田博秋

日本精神神経学会総会プログラム・抄録集　111th　S.364　2015
精神病圏と鑑別を要した周産期うつ病の2例

小林奈津子, 菊地紗耶, 桂雅宏, 上野草太, 橋田かなえ, 玉澤和彦, 本多奈美

日本周産期メンタルヘルス研究会学術集会　11th　36　2014
【緊急有事における産婦人科体制づくり】被災地の妊産婦のPTSDとその対策 (産婦人科の実際)

小澤克典, 室月淳, 菊地紗耶, 小林奈津子, 八重樫伸生

産婦人科の実際　61　(1)　77-83　2012/01

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Books and Other Publications 1

Psychopharmacology and Pregnancy

Megan G, Martien S, Andrew

2017

Research Projects 2

Elucidation of the etiology of postpartum depression through integrated genome-phenome analysis

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2023/04/01 - 2026/03/31
高齢出産妊婦の効果的な支援方法の検討

小林奈津子

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 若手研究

Institution: 東北大学

2020/04/01 - 2023/03/31

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高齢出産に伴う問題ないし利点について、文献的レビューを追加している。出産年齢の高齢化が養育行動や愛着形成、児の発達に与える影響については、未だ知見が乏しい状況である。高齢出産妊婦の支援を考える上で注目すべき、妊婦の心理・社会的リスク、身体的・精神的健康状態、精神疾患罹患率（妊娠合併症）、児の出生・発育状況について、東北大学メディカル・メガバンク事業における三世代コホートおよびそのアドオンコホートよりデータの移譲を受け、解析を進めている。データには妊娠初期、中期、産後に渡る情報が含まれており、妊娠受容の状態、不妊治療の有無、就労状況、経済状況、育児支援を含む家庭の状況などの項目を中心に、主にはそれらの妊娠年齢による差異を検討する見込みである。当科の周産期メンタルケア外来における妊産婦の縦断的調査については、このようなメンタルヘルスにおけるハイリスクグループにおいても、養育における困難や愛着形成に関し高齢出産であることの影響があるかを検討する予定であった。しかし、診療録の後方視的検討を行ったところ、疾患に伴う機能障害の程度の影響が大きいことが予想され、年齢による差異は検出しがたい状況がみえてきた。臨床例のほうがより詳細な情報を含んでいることを活かせるような、他の切り口について検討中である。 COVID-19の影響を受けていた各種学会もオンライン参加やハイブリット開催が一般的になっており、引き続き情報収集や学会発表を行っていく。

Teaching Experience 3

発達心理学　東北大学医学部保健学科
リエゾン精神看護　東北大学医学部保健学科
精神看護方法論　東北大学医学部保健学科