Details of the Researcher

PHOTO

Minoru Ueda
Section
Graduate School of Science
Job title
Professor
Degree
  • 博士(農学)(名古屋大学)

  • 農学修士(名古屋大学)

Research History 5

  • 2018/04 - Present
    Tohoku University Graduate School of Life Sciences, Department of Molecular and Chemical Life Sciences

  • 2004/02 - Present
    Tohoku University Graduate School of Science, Department of Chemistry

  • 2001/04 - 2004/01
    Keio University Faculty of Science and Technology

  • 1999/04 - 2001/03
    Keio University Faculty of Science and Technology

  • 1994/04 - 1999/03
    Keio University Faculty of Science and Technology

Education 3

  • Nagoya University

    1991/04 - 1994/03

  • Nagoya University

    1989/04 - 1991/03

  • Konan University

    1985/04 - 1989/03

Committee Memberships 45

  • 公益財団法人 内藤記念科学振興財団 選考委員長

    2025/08 - Present

  • 日本化学会 ナカニシプライズ選考委員長

    2025/06 - Present

  • 日本植物化学調節学会 植物化学調節学会第61回大会(仙台)オーガナイザー

    2025/04 - Present

  • BMC Biology Guest Editor for “Plant communication” collection

    2025/02 - Present

  • 植物化学研究会 第61回植物化学シンポジウム(東京)オーガナイザー

    2024/11 - Present

  • IUPAC International Symposium on the Chemistry of Natural Products (ISCNP33-ICOB13) Organizer

    2024/05 - Present

  • Editorial Board Member of Scientific Reports

    2023/05 - Present

  • 日本化学会 ディビジョン(天然物化学・生命科学)幹事

    2023/03 - Present

  • 植物化学研究会(植物化学シンポジウム)世話人

    2022/11 - Present

  • 公益財団法人 内藤記念科学振興財団 選考委員

    2022/04 - Present

  • 日本ケミカルバイオロジー学会 顧問

    2021/06 - Present

  • 公益財団法人 サントリー生命科学財団・サントリー生物有機科学研究所 理事

    2018/06 - Present

  • IUPAC International Symposium on the Chemistry of Natural Products and the International Conference on Biodiversity Advisory Board Committee Member

    2018 - Present

  • 植物化学調節学会 代議員

    2016/10 - Present

  • 天然有機化合物討論会 天然有機化合物討論会世話人

    2004/10 - Present

  • 日本農芸化学会 日本農芸化学会東北支部評議員

    2004/10 - Present

  • 日本化学会 日本化学会学会賞選考委員会委員

    2023/04 - 2025/03

  • 日本農芸化学会 学術活動強化委員会委員

    2019/04 - 2025/03

  • 植物化学研究会 第58回植物化学シンポジウム実行委員長

    2022/04 - 2023/03

  • 日本化学会 ディビジョン(天然物化学・生命科学)副主査

    2021/04 - 2023/03

  • 日本ケミカルバイオロジー学会 幹事

    2015/06 - 2021/05

  • 第31回万有仙台シンポジウムオーガナイザー

    2020/04 - 2021/03

  • 日本化学会 ディビジョン(天然物化学・生命科学)幹事

    2016 - 2021/03

  • 新規素材探索研究会 新規素材探索研究会幹事

    2002/04 - 2021/02

  • 万有仙台シンポジウム 万有仙台シンポジウム組織委員

    2004/06 - 2020/11

  • 文部科学省 新学術領域研究(複合領域)審査委員主査

    2019/04 - 2020/03

  • サントリー生命科学財団 SunRiSE生命科学研究者支援プログラム選考委員

    2019 - 2020

  • 文部科学省 新学術領域研究(複合領域)審査委員

    2018/04 - 2019/03

  • 植物化学調節学会 評議員

    2008/10 - 2016/09

  • 日本ケミカルバイオロジー学会 第10回日本ケミカルバイオロジー学会年会オーガナイザー

    2015/04 - 2016/03

  • 日本化学会 ディビジョン(天然物化学・生命科学)主査

    2012 - 2016

  • 25周年記念万有仙台シンポジウムオーガナイザー

    2014/04 - 2015/03

  • 東北大学 グローバルCOEプログラム「分子系高次構造体化学国際教育研究拠点」サブリーダー

    2007/04 - 2012/03

  • 天然物化学談話会 天然物化学談話会世話人代表

    2007/07 - 2010/06

  • 内藤記念科学振興財団 The 20th Naito Conference on “Chemical Biology I”、組織委員

    2008/03 - 2009/04

  • 第18回万有仙台シンポジウム組織委員長

    2007/04 - 2008/03

  • 有機合成化学協会 有機合成化学協会誌編集協力委員

    2006/04 - 2008/03

  • 日本化学会 日本化学会速報誌Chemistry Letters編集委員

    2006/04 - 2008/03

  • 天然物化学談話会 天然物化学談話会世話人

    1998/07 - 2007/06

  • 山田科学振興財団 The 2nd Yamada Symposium on Key Natural Organic Molecules in Biological Systems, Organizer (2005)

    2005/04 - 2006/03

  • 日本農芸化学会 日本農芸化学会評議員

    2004/04 - 2006/03

  • 日本学術会議 日本学術会議特別委員会「子供の理科離れ対策委員会」講演会運営委員

    2004/04 - 2005/03

  • 日本化学会 日本化学会関東支部教育関連部会委員

    2002/04 - 2004/03

  • International Plant Growth Substance Association 2025 (IPGSA2025) Conference Chair of Session “Hormone Metabolism A”

    2024/07 -

  • 経済産業省 個別化医療に向けた次世代医薬品創出基盤技術開発(天然化合物及びITを活用した革新的医薬品創出技術)事業推進委員会委員

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Professional Memberships 5

  • JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

  • 植物化学調節学会

  • 有機合成化学協会

  • 日本農芸化学会

  • 日本化学会

Research Interests 11

  • 分子進化

  • 受容体タンパク質

  • plant specialized metabolites

  • 天然物ケミカルバイオロジー

  • 就眠運動

  • ジャスモン酸

  • 植物ホルモン

  • 植物科学

  • ケミカルバイオロジー

  • 生理活性物質

  • 天然物有機化学

Research Areas 3

  • Life sciences / Bioorganic chemistry /

  • Nanotechnology/Materials / Chemical biology /

  • Nanotechnology/Materials / Molecular biochemistry /

Awards 7

  1. 日本農芸化学会大会トピックス賞 2024年度東京大会(第14回)

    2024/04 日本農芸化学会

  2. 長瀬研究振興賞

    2022/04 長瀬科学技術振興財団

  3. BBB論文賞

    2017/03 日本農芸化学会

  4. 植物化学調節学会学会賞

    2013/10/31 植物化学調節学会

  5. 第9回 読売テクノフォーラム・ゴールドメダル賞

    2003/04 読売新聞社

  6. 第49回 日本化学会進歩賞受賞

    2000/03 日本化学会

  7. 第13回若い世代の特別講演会表彰

    1998/10 日本化学会

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Papers 206

  1. A Reactive Antagonist Strategy: Cysteine-directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

    M. Ueda, K. Matsumoto, T. Nomura, Y. Takaoka, W. Kozaki, H. Hoshikawa, Y. Nishizato, T. Okumura, A. Chini, R. Solano, K. Maenaka

    2025/08

  2. Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana Peer-reviewed

    Minoru Ueda, Rina Saito, Yuho Nishizato, Tsumugi Kitajima, Nobuki Kato

    Nature Communications 16 (1) 6683 2025/07/21

    Publisher: Springer Science and Business Media LLC

    DOI: 10.1038/s41467-025-61072-x  

    eISSN: 2041-1723

  3. Recent advances in the chemistry and biology of plant oxylipin hormones Peer-reviewed

    Yuho Nishizato, Taichi Okumura, Kotaro Matsumoto, Minoru Ueda

    Natural Product Reports 2025/04

    Publisher: Royal Society of Chemistry (RSC)

    DOI: 10.1039/d5np00006h  

    ISSN: 0265-0568

    eISSN: 1460-4752

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    Oxylipin plant hormone jasmonates induce various plant responses, including defense against attacks of insects or pathogens and tolerance against environmental stresses. Jasmonates function as unique “molecular glue degraders” in plant cells.

  4. Dinor-12-oxo-phytodienoic acid conjugation with amino acids inhibits its phytohormone bioactivity in Marchantia polymorpha Peer-reviewed

    Wenting Liang, Ángel M Zamarreño, Salvador Torres-Montilla, Antonio de la Torre, Jean Chrisologue Totozafy, Takuya Kaji, Minoru Ueda, Massimiliano Corso, José M García-Mina, Roberto Solano, Andrea Chini

    Plant Physiology 197 (1) 2025/01

    Publisher: Oxford University Press (OUP)

    DOI: 10.1093/plphys/kiae610  

    ISSN: 0032-0889

    eISSN: 1532-2548

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    Abstract Jasmonates (JAs) are important phytohormones that regulate plant tolerance to biotic and abiotic stresses, and developmental processes. Distinct JAs in different plant lineages activate a conserved signaling pathway that mediates these responses: dinor-12-oxo-phytodienoic acid (dn-OPDA) isomers in bryophytes and lycophytes, and JA-Ile in most vascular plants. In many cases, the final responses triggered by these phytohormones depend on the accumulation of specialized metabolites. To identify compounds regulated by the dn-OPDA pathway in the liverwort Marchantia polymorpha, untargeted metabolomic analyses were carried out in response to wounding, a stress that activates the dn-OPDA pathway. A previously unreported group of molecules was identified from these analyses: dn-OPDA-amino acid conjugates (dn-OPDA-aas). Their accumulation after wounding and herbivory was confirmed by targeted metabolic profiling in Marchantia and in all species in which we previously detected dn-iso-OPDA. Mutants in GRETCHEN-HAGEN 3A (MpGH3A) failed to accumulate dn-OPDA-aa conjugates and showed a constitutive activation of the OPDA pathway and increased resistance to herbivory. Our results show that dn-iso-OPDA bioactivity is reduced by amino acid conjugation. Therefore, JA conjugation in land plants plays dichotomous roles: jasmonic acid conjugation with isoleucine (Ile) produces the bioactive JA-Ile in tracheophytes, whereas conjugation of dn-iso-OPDA with different amino acids deactivates the phytohormone in bryophytes and lycophytes.

  5. Amide conjugates of the jasmonate precursor cis-(+)-12-oxo-phytodienoic acid regulate its homeostasis during plant stress responses Peer-reviewed

    Jitka Široká, Anita Ament, Václav Mik, Tomáš Pospíšil, Michaela Kralová, Chao Zhang, Markéta Pernisová, Michal Karady, Vladimira Nožková, Yuho Nishizato, Takuya Kaji, Rina Saito, Mohamed Htitich, Kristýna Floková, Claus Wasternack, Miroslav Strnad, Minoru Ueda, Ondřej Novák, Federica Brunoni

    Plant Physiology 197 (1) 2025/01

    Publisher: Oxford University Press (OUP)

    DOI: 10.1093/plphys/kiae636  

    ISSN: 0032-0889

    eISSN: 1532-2548

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    Abstract Jasmonates are a family of oxylipin phytohormones regulating plant development and growth and mediating “defense versus growth” responses. The upstream JA biosynthetic precursor cis-(+)-12-oxo-phytodienoic acid (cis-OPDA) acts independently of CORONATIVE INSENSITIVE 1-mediated JA signaling in several stress-induced and developmental processes. However, its perception and metabolism are only partially understood. An isoleucine analog of the biologically active JA-Ile, OPDA-Ile, was detected years ago in wounded leaves of flowering plants, opening up the possibility that conjugation of cis-OPDA to amino acids might be a relevant mechanism for cis-OPDA regulation. Here, we extended the analysis of amino acid conjugates of cis-OPDA and identified naturally occurring OPDA-Val, OPDA-Phe, OPDA-Ala, OPDA-Glu, and OPDA-Asp accumulating in response to biotic and abiotic stress in Arabidopsis (Arabidopsis thaliana). The OPDA amino acid conjugates displayed cis-OPDA-related plant responses in a JA-Ile-dependent manner. We also showed that the synthesis and hydrolysis of cis-OPDA amino acid conjugates are mediated by members of the amidosynthetase GRETCHEN HAGEN 3 and the amidohydrolase INDOLE-3-ACETYL-LEUCINE RESISTANT 1/ILR1-like families. Thus, OPDA amino acid conjugates function in the catabolism or temporary storage of cis-OPDA in stress responses instead of acting as chemical signals per se.

  6. Δ4-dn-iso-OPDA, a bioactive plant hormone of Marchantia polymorpha Peer-reviewed

    Takuya Kaji, Yuho Nishizato, Hidenori Yoshimatsu, Akiyoshi Yoda, Wenting Liang, Andrea Chini, Gemma Fernández-Barbero, Kei Nozawa, Junko Kyozuka, Roberto Solano, Minoru Ueda

    iScience 110191-110191 2024/06

    Publisher: Elsevier BV

    DOI: 10.1016/j.isci.2024.110191  

    ISSN: 2589-0042

  7. An outward-rectifying plant K+ channel SPORK2 exhibits temperature-sensitive ion-transport activity Peer-reviewed

    Yuki Muraoka, Gangqiang Yang, Shintaro Munemasa, Yusuke Takeuchi, Yasuhiro Ishimaru, Yoshiyuki Murata, Nobuyuki Uozumi, Minoru Ueda

    Current Biology 33 5488-5494 2023/11

    Publisher: Elsevier BV

    DOI: 10.1016/j.cub.2023.10.057  

    ISSN: 0960-9822

  8. (3R,7S)‐12‐Hydroxy‐jasmonoyl‐L‐isoleucine is the genuine bioactive stereoisomer of a jasmonate metabolite in Arabidopsis thaliana Peer-reviewed

    Rina Saito, Toshiya Muto, Haruyuki Urano, Tsumugi Kitajima, Nobuki Kato, Eunsang Kwon, Minoru Ueda

    The Plant Journal 115 709-723 2023/05/13

    Publisher: Wiley

    DOI: 10.1111/tpj.16256  

    ISSN: 0960-7412

    eISSN: 1365-313X

  9. Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine Peer-reviewed

    Kengo Hayashi, Nobuki Kato, Khurram Bashir, Haruna Nomoto, Misuzu Nakayama, Andrea Chini, Satoshi Takahashi, Hiroaki Saito, Raku Watanabe, Yousuke Takaoka, Maho Tanaka, Atsushi J. Nagano, Motoaki Seki, Roberto Solano, Minoru Ueda

    Communications Biology 6 (320) 2023/03

    DOI: 10.1038/s42003-023-04709-1  

  10. Ligand diversity guarantees full activation of the jasmonate pathway in Marchantia polymorpha Peer-reviewed

    S. Kneeshaw, G. Soriano, I. Monte, M. Hamberg, Á. M. Zamarreño, J. M. García-Mina, J. M. Franco-Zorrilla, N. Kato, M. Ueda, M F. Rey-Stolle, C. Barbas, S. Michavila, S. Gimenez-Ibanez, G. H. Jimenez-Alemán, R Solano

    PNAS 119 (36) e2202930119 2022/08

    DOI: 10.1073/pnas.2202930119  

  11. A rationally designed JAZ subtype-selective agonist of jasmonate perception Peer-reviewed

    Y. Takaoka, M. Iwahashi, A. Chini, H. Saito, Y. Ishimaru, S. Egoshi, N. Kato, M. Tanaka, K. Bashir, M. Seki, R. Solano, M. Ueda

    Nature Communications 9 3654 2018/09

    DOI: 10.1038/s41467-018-06135-y  

    ISSN: 2041-1723

  12. Ion Channels Regulate Nyctinastic Leaf Opening in Samanea saman Peer-reviewed

    Takaya Oikawa, Yasuhiro Ishimaru, Shintaro Munemasa, Yusuke Takeuchi, Kento Washiyama, Shin Hamamoto, Nobuyuki Yoshikawa, Yoshiyuki Mutara, Nobuyuki Uozumi, Minoru Ueda

    Current Biology 28 2230-2238 2018

    Publisher: Cell Press

    DOI: 10.1016/j.cub.2018.05.042  

    ISSN: 0960-9822

  13. Noncanonical Function of a Small-Molecular Virulence Factor Coronatine against Plant Immunity: An In Vivo Raman Imaging Approach Peer-reviewed

    Minoru Ueda, Syusuke Egoshi, Kosuke Dodo, Yasuhiro Ishimaru, Hiroyuki Yamakoshi, Takeshi Nakano, Yousuke Takaoka, Shinya Tsukiji, Mikiko Sodeoka

    ACS Central Science 3 (5) 462-472 2017/05/04

    DOI: 10.1021/acscentsci.7b00099  

    ISSN: 2374-7943

    eISSN: 2374-7951

  14. AtSWEET13 and AtSWEET14 regulate gibberellin-mediated physiological processes Peer-reviewed

    Yuri Kanno, Takaya Oikawa, Yasutaka Chiba, Yasuhiro Ishimaru, Takafumi Shimizu, Naoto Sano, Tomokazu Koshiba, Yuji Kamiya, Minoru Ueda, Mitsunori Seo

    Nature Communications 7 (1) 2016/10/26

    DOI: 10.1038/ncomms13245  

    ISSN: 2041-1723

    eISSN: 2041-1723

  15. The jasmonate-responsive GTR1 transporter is required for gibberellin-mediated stamen development in Arabidopsis Peer-reviewed

    Hikaru Saito, Takaya Oikawa, Shin Hamamoto, Yasuhiro Ishimaru, Miyu Kanamori-Sato, Yuko Sasaki-Sekimoto, Tomoya Utsumi, Jing Chen, Yuri Kanno, Shinji Masuda, Yuji Kamiya, Mitsunori Seo, Nobuyuki Uozumi, Minoru Ueda, Hiroyuki Ohta

    Nature Communications 6 (1) 2015/02/04

    DOI: 10.1038/ncomms7095  

    ISSN: 2041-1723

    eISSN: 2041-1723

  16. 12-Hydroxyjasmonic Acid Glucoside Is a COI1-JAZ-Independent Activator of Leaf-Closing Movement in Samanea saman Peer-reviewed

    Yoko Nakamura, Axel Mithöfer, Erich Kombrink, Wilhelm Boland, Shin Hamamoto, Nobuyuki Uozumi, Kentaro Tohma, Minoru Ueda

    Plant Physiology 155 (3) 1226-1236 2011/01/12

    DOI: 10.1104/pp.110.168617  

    ISSN: 0032-0889

    eISSN: 1532-2548

  17. Enantiodifferential Approach for the Detection of the Target Membrane Protein of the Jasmonate Glycoside that Controls the Leaf Movement ofAlbizzia saman Peer-reviewed

    Yoko Nakamura, Ryoji Miyatake, Minoru Ueda

    Angewandte Chemie International Edition 47 (38) 7289-7292 2008/09/08

    DOI: 10.1002/anie.200801820  

    ISSN: 1433-7851

    eISSN: 1521-3773

  18. Metabolites involved in plant movement and ‘memory’: nyctinasty of legumes and trap movement in the Venus flytrap Invited Peer-reviewed

    Minoru Ueda, Yoko Nakamura

    Nat. Prod. Rep. 23 (4) 548-557 2006

    DOI: 10.1039/b515708k  

    ISSN: 0265-0568

    eISSN: 1460-4752

  19. Chemistry and Biology of Plant Leaf Movements Peer-reviewed

    Minoru Ueda, Shosuke Yamamura

    Angewandte Chemie International Edition 39 (8) 1400-1414 2000/04/17

    DOI: 10.1002/(sici)1521-3773(20000417)39:8<1400::aid-anie1400>3.0.co;2-z  

    ISSN: 1433-7851

    eISSN: 1521-3773

  20. A structure-redesigned intrinsically disordered peptide that selectively inhibits a plant transcription factor in jasmonate signaling Peer-reviewed

    Yousuke Takaoka, Ruiqi Liu, Minoru Ueda

    PNAS Nexus 3 (8) 312 2024/07/26

    Publisher: Oxford University Press (OUP)

    DOI: 10.1093/pnasnexus/pgae312  

    eISSN: 2752-6542

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    Abstract Plant hormone-related transcription factors (TFs) are key regulators of plant development, responses to environmental stress such as climate changes, pathogens, and pests. These TFs often function as families that exhibit genetic redundancy in higher plants, and are affected by complex crosstalk mechanisms between different plant hormones. These properties make it difficult to analyze and control them in many cases. In this study, we introduced a chemical inhibitor to manipulate plant hormone-related TFs, focusing on the jasmonate (JA) and ethylene (ET) signaling pathways, with the key TFs MYC2/3/4 and EIN3/EIL1. This study revealed that JAZ10CMID, the binding domain of the repressor involved in the desensitization of both TFs, is an intrinsically disordered region in the absence of binding partners. Chemical inhibitors have been designed based on this interaction to selectively inhibit MYC TFs while leaving EIN3/EIL1 unaffected. This peptide inhibitor effectively disrupts MYC-mediated responses while activating EIN3-mediated responses and successfully uncouples the crosstalk between JA and ET signaling in Arabidopsis thaliana. Furthermore, the designed peptide inhibitor was also shown to selectively inhibit the activity of MpMYC, an ortholog of AtMYC in Marchantia polymorpha, demonstrating its applicability across different plant species. This underscores the potential of using peptide inhibitors for specific TFs to elucidate hormone crosstalk mechanisms in non-model plants without genetic manipulation. Such a design concept for chemical fixation of the disordered structure is expected to limit the original multiple binding partners and provide useful chemical tools in chemical biology research.

  21. Identification of “modified OPDA (mo-OPDA)” as a Michael adduct of cis-OPDA Peer-reviewed

    Yuho Nishizato, Yuki Muraoka, Mai Morikawa, Rina Saito, Takuya Kaji, Minoru Ueda

    Bioscience, Biotechnology, and Biochemistry 88 (8) 885-891 2024/05/02

    Publisher: Oxford University Press (OUP)

    DOI: 10.1093/bbb/zbae056  

    eISSN: 1347-6947

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    ABSTRACT cis-(+)-12-Oxo-phytodienoic acid (cis-OPDA) is a significant plant oxylipin, known as a biosynthetic precursor of the plant hormone jasmonoyl-l-isoleucine (JA-Ile), and a bioactive substance in plant environmental stresses. A recent study showed that a plant dioxygenase, Jasmonate Induced Dioxygenase 1 (JID1), converts cis-OPDA into an unidentified metabolite termed “modified-OPDA (mo-OPDA)” in Arabidopsis thaliana. Here, using ultra-performance liquid chromatography coupled with triple quad mass spectrometry (UPLC-MS/MS) experiment, the chemical identity of “mo-OPDA” was demonstrated and identified as a conjugate between cis-OPDA and 2-mercaptoethanol (cis-OPDA-2ME), an artifact produced by Michael addition during the JID1 digestion of cis-OPDA. However, previous reports demonstrated a decreased accumulation of cis-OPDA in the JID1-OE line, suggesting the existence of an unknown JID1-mediated mechanism regulating the level of cis-OPDA in A. thaliana.

  22. SlCYP94B18 and SlCYP94B19 monooxygenases for the catabolic turnover of jasmonates in tomato leaves Peer-reviewed

    Rina Saito, Mai Morikawa, Toshiya Muto, Sayaka Saito, Takuya Kaji, Minoru Ueda

    Phytochemistry 2024/05

    DOI: 10.1016/j.phytochem.2024.114141  

  23. Nyctinasty Peer-reviewed

    Yuki Muraoka, Minoru Ueda

    Current Biology 34 (8) R307-R308 2024/04

    Publisher: Elsevier BV

    DOI: 10.1016/j.cub.2024.02.047  

    ISSN: 0960-9822

  24. Two distinct modes of action of molecular glues in the plant hormone co-receptor COI1-JAZ system Peer-reviewed

    Takuya Kaji, Kotaro Matsumoto, Taichi Okumura, Misuzu Nakayama, Shunji Hoshino, Yousuke Takaoka, Jianxin Wang, Minoru Ueda

    iScience 27 (1) 108625-108625 2024/01

    Publisher: Elsevier BV

    DOI: 10.1016/j.isci.2023.108625  

    ISSN: 2589-0042

  25. Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model Peer-reviewed

    Shusei Yamamoto, Ikumi Sato, Moe Fujii, Mai Kakimoto, Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Satoru Tamura, Minoru Ueda, Satoshi Hirohata, Shogo Watanabe

    Canadian Journal of Physiology and Pharmacology 101 (9) 455-465 2023/09/01

    Publisher: Canadian Science Publishing

    DOI: 10.1139/cjpp-2022-0532  

    ISSN: 0008-4212

    eISSN: 1205-7541

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    The liver X receptor (LXR) can enhance cholesterol transporters, which could remove excess cholesterol from foam cells in atheromas. LXR has two subtypes: LXRα, which aggravates hepatic lipid accumulation, and LXRβ, which does not. In 2018, ouabagenin (OBG) was reported as a potential LXRβ-specific agonist. We aimed to examine whether OBG specifically affects LXRβ in nonalcoholic steatohepatitis (NASH); it did not aggravate hepatic steatosis and can suppress the development of atherosclerosis. SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet were divided into four groups as follows: (I) L-NAME group, (II) L-NAME/OBG group, (III) OBG (−) group, and (IV) OBG (+) group. All groups’ rats were intraperitoneally administered L-NAME. The L-NAME/OBG group’s rats were intraperitoneally administered OBG and L-NAME simultaneously. After L-NAME administration, the OBG (+) group’s rats were administered OBG, while the OBG (−) group’s rats were not. Although all rats developed NASH, OBG did not exacerbate steatosis (L-NAME/OBG and OBG (+) groups). In addition, endothelial cells were protected in the L-NAME/OBG group and foam cells in the atheroma were reduced in the OBG (+) group. OBG is an LXRβ-specific agonist and has a potential therapeutic effect on atherosclerosis without developing lipid accumulation in the liver.

  26. Difference in the ligand affinity among redundant plant hormone receptors of rice OsCOI1a/1b/2-OsJAZs Peer-reviewed

    Taichi Okumura, Tsumugi Kitajima, Takuya Kaji, Haruyuki Urano, Kotaro Matsumoto, Hideo Inagaki, Koji Miyamoto, Kazunori Okada, Minoru Ueda

    Bioscience, Biotechnology, and Biochemistry 87 (10) 1122-1128 2023/07/04

    Publisher: Oxford University Press (OUP)

    DOI: 10.1093/bbb/zbad092  

    eISSN: 1347-6947

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    ABSTRACT (3R, 7S)-jasmonoyl-L-isoleucine (JA-Ile) is a lipid-derived plant hormone that regulates plant responses, including biotic/abiotic stress adaptation. In the plant cells, JA-Ile is perceived by COI1-JAZ co-receptor by causing protein-protein interaction between COI1 and JAZ proteins to trigger gene expressions. In this study, we focused on Oryza sativa, a model monocot and an important crop, with 45 possible OsCOI-OsJAZ co-receptor pairs composed of three OsCOI homologs (OsCOI1a, OsCOI1b, and OsCOI2) and 15 OsJAZ homologs. We performed fluorescein anisotropy and pull-down assays to examine the affinity between JA-Ile and OsCOI1a/1b/2-OsJAZ1-15 co-receptor pairs. The results revealed a remarkable difference in the modes of ligand perception by OsCOI1a/1b and OsCOI2. Recently, the unique function of OsCOI2 in some of the JA-responses were revealed. Our current results will lead to the possible development of OsCOI2-selective synthetic ligand.

  27. Design, synthesis, and discovery of Eudistomin Y derivatives as lysosome-targeted antiproliferation agents Peer-reviewed

    Gangqiang Yang, Hao Xie, Conghui Wang, Chen Zhang, Liping Yu, Luyu Zhang, Xin Liu, Ruoxuan Xu, Zhihua Song, Rongxia Liu, Minoru Ueda

    European Journal of Medicinal Chemistry 115193-115193 2023/02

    Publisher: Elsevier BV

    DOI: 10.1016/j.ejmech.2023.115193  

    ISSN: 0223-5234

  28. Host-Selective Phytotoxins Incorporating the Epoxy-Triene-Decacarboxylate Moiety Function through the Hijacking of the Plant–Microbe Interaction System Peer-reviewed

    Minoru Ueda, Nobuki Kato, Yoshinori Kurata, Masaki Imai, Gangqiang Yang, Keigo Taniguchi

    ACS Chemical Biology 18 (1) 12-17 2023/01/20

    Publisher: American Chemical Society (ACS)

    DOI: 10.1021/acschembio.2c00777  

    ISSN: 1554-8929

    eISSN: 1554-8937

  29. Genome Editing Reveals Both the Crucial Role of OsCOI2 in Jasmonate Signaling and the Functional Diversity of COI1 Homologs in Rice Peer-reviewed

    Hideo Inagaki, Kengo Hayashi, Yousuke Takaoka, Hibiki Ito, Yuki Fukumoto, Ayaka Yajima-Nakagawa, Xi Chen, Miyuki Shimosato-Nonaka, Emmi Hassett, Kodai Hatakeyama, Yuko Hirakuri, Masanobu Ishitsuka, Emi Yumoto, Tomoko Sakazawa, Masashi Asahina, Kenichi Uchida, Kazunori Okada, Hisakazu Yamane, Minoru Ueda, Koji Miyamoto

    Plant and Cell Physiology 64 (4) 405-421 2022/12/06

    Publisher: Oxford University Press (OUP)

    DOI: 10.1093/pcp/pcac166  

    ISSN: 0032-0781

    eISSN: 1471-9053

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    Abstract Jasmonic acid (JA) regulates plant growth, development and stress responses. Coronatine insensitive 1 (COI1) and jasmonate zinc-finger inflorescence meristem-domain (JAZ) proteins form a receptor complex for jasmonoyl-l-isoleucine, a biologically active form of JA. Three COIs (OsCOI1a, OsCOI1b and OsCOI2) are encoded in the rice genome. In the present study, we generated mutants for each rice COI gene using genome editing to reveal the physiological functions of the three rice COIs. The oscoi2 mutants, but not the oscoi1a and oscoi1b mutants, exhibited severely low fertility, indicating the crucial role of OsCOI2 in rice fertility. Transcriptomic analysis revealed that the transcriptional changes after methyl jasmonate (MeJA) treatment were moderate in the leaves of oscoi2 mutants compared to those in the wild type or oscoi1a and oscoi1b mutants. MeJA-induced chlorophyll degradation and accumulation of antimicrobial secondary metabolites were suppressed in oscoi2 mutants. These results indicate that OsCOI2 plays a central role in JA response in rice leaves. In contrast, the assessment of growth inhibition upon exogenous application of JA to seedlings of each mutant revealed that rice COIs are redundantly involved in shoot growth, whereas OsCOI2 plays a primary role in root growth. In addition, a co-immunoprecipitation assay showed that OsJAZ2 and OsJAZ5 containing divergent Jas motifs physically interacted only with OsCOI2, whereas OsJAZ4 with a canonical Jas motif interacts with all three rice COIs. The present study demonstrated the functional diversity of rice COIs, thereby providing clues to the mechanisms regulating the various physiological functions of JA.

  30. Coordinately regulated transcription factors EIN3/EIL1 and MYCs in ethylene and jasmonate signaling interact with the same domain of MED25. International-journal Peer-reviewed

    Ruiqi Liu, Hikaru Niimi, Minoru Ueda, Yousuke Takaoka

    Bioscience, biotechnology, and biochemistry 2022/07/25

    DOI: 10.1093/bbb/zbac119  

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    Ethylene (ET) and jasmonate (JA) are plant hormones that act synergistically to regulate plant development and defense against necrotrophic fungi infections, and antagonistically in response to wounds and apical hook formation. Previous studies revealed that the coordination of these responses is due to dynamic protein-protein interactions (PPI) between their master transcription factors (TFs) EIN3/EIL1 and MYC in ET and JA signaling, respectively. In addition, both TFs are activated via interactions with the same transcriptional mediator MED25, which upregulates downstream gene expression. Herein, we analyzed the PPI between EIN3/EIL1 and MED25, and as with the PPI between MYC3 and MED25, found that the short binding domain of MED25 (CMIDM) is also responsible for the interaction with EIN3/EIL1 - a finding which suggests that both TFs compete for binding with MED25. These results further inform our understanding of the coordination between the ET and JA regulatory systems.

  31. Sustained defense response via volatile signaling and its epigenetic transcriptional regulation. International-journal

    Haruki Onosato, Genya Fujimoto, Tomota Higami, Takuya Sakamoto, Ayaka Yamada, Takamasa Suzuki, Rika Ozawa, Sachihiro Matsunaga, Motoaki Seki, Minoru Ueda, Kaori Sako, Ivan Galis, Gen-Ichiro Arimura

    Plant physiology 189 (2) 922-933 2022/06/01

    DOI: 10.1093/plphys/kiac077  

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    Plants perceive volatiles emitted from herbivore-damaged neighboring plants to urgently adapt or prime their defense responses to prepare for forthcoming herbivores. Mechanistically, these volatiles can induce epigenetic regulation based on histone modifications that alter the transcriptional status of defense genes, but little is known about the underlying mechanisms. To understand the roles of such epigenetic regulation of plant volatile signaling, we explored the response of Arabidopsis (Arabidopsis thaliana) plants to the volatile β-ocimene. Defense traits of Arabidopsis plants toward larvae of Spodoptera litura were induced in response to β-ocimene, through enriched histone acetylation and elevated transcriptional levels of defense gene regulators, including ethylene response factor genes (ERF8 and ERF104) in leaves. The enhanced defense ability of the plants was maintained for 5 d but not over 10 d after exposure to β-ocimene, and this coincided with elevated expression of those ERFs in their leaves. An array of histone acetyltransferases, including HAC1, HAC5, and HAM1, were responsible for the induction and maintenance of the anti-herbivore property. HDA6, a histone deacetylase, played a role in the reverse histone remodeling. Collectively, our findings illuminate the role of epigenetic regulation in plant volatile signaling.

  32. 12-Hydroxyjasmonic acid glucoside causes leaf-folding of Samanea saman through ROS accumulation. International-journal Peer-reviewed

    Gangqiang Yang, Yasuhiro Ishimaru, Shunji Hoshino, Yuki Muraoka, Nobuyuki Uozumi, Minoru Ueda

    Scientific reports 12 (1) 7232-7232 2022/05/04

    DOI: 10.1038/s41598-022-11414-2  

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    Foliar nyctinasty, a circadian rhythmic movement in plants, is common among leguminous plants and has been widely studied. Biological studies on nyctinasty have been conducted using Samanea saman as a model plant. It has been shown that the circadian rhythmic potassium flux from/into motor cells triggers cell shrinking/swelling to cause nyctinastic leaf-folding/opening movement in S. saman. Recently, 12-hydroxyjasmonic acid glucoside (JAG) was identified as an endogenous chemical factor causing leaf-folding of S. saman. Additionally, SPORK2 was identified as an outward-rectifying potassium channel that causes leaf-movement in the same plant. However, the molecular mechanism linking JAG and SPORK2 remains elusive. Here, we report that JAG induces leaf-folding through accumulation of reactive oxygen species in the extensor motor cells of S. saman, and this occurs independently of plant hormone signaling. Furthermore, we show that SPORK2 is indispensable for the JAG-triggered shrinkage of the motor cell. This is the first report on JAG, which is believed to be an inactivated/storage derivative of JA, acting as a bioactive metabolite in plant.

  33. Protein–protein interactions between jasmonate-related master regulator MYC and transcriptional mediator MED25 depend on a short binding domain Peer-reviewed

    Yousuke Takaoka, Kaho Suzuki, Akira Nozawa, Hirotaka Takahashi, Tatsuya Sawasaki, Minoru Ueda

    Journal of Biological Chemistry 298 (1) 101504-101504 2022/01

    Publisher: Elsevier BV

    DOI: 10.1016/j.jbc.2021.101504  

    ISSN: 0021-9258

    eISSN: 1083-351X

  34. Extended JAZ degron sequence for plant hormone binding in jasmonate co-receptor of tomato SlCOI1-SlJAZ International-journal Peer-reviewed

    R. Saito, K. Hayashi, H. Nomoto, M. Nakayama, Y. Takaoka, S. Yamagami, T. Muto, M. Ueda

    Scientific Reports 11 (1) 13612-13612 2021/06

    DOI: 10.1038/s41598-021-93067-1  

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    (+)-7-iso-Jasmonoyl-L-isoleucine (JA-Ile) is a lipid-derived phytohormone implicated in plant development, reproduction, and defense in response to pathogens and herbivorous insects. All these effects are instigated by the perception of JA-Ile by the COI1-JAZ co-receptor in the plant body, which in Arabidopsis thaliana is profoundly influenced by the short JAZ degron sequence (V/L)P(Q/I)AR(R/K) of the JAZ protein. Here, we report that SlJAZ-SlCOI1, the COI1-JAZ co-receptor found in the tomato plant, relies on the extended JAZ degron sequence (V/L)P(Q/I)AR(R/K)XSLX instead of the canonical JAZ degron. This finding illuminates our understanding of the mechanism of ligand perception by JA-Ile in this plant, and will inform both efforts to improve it by genetic modification of the SlCOI1-SlJAZ co-receptor, and the development of the synthetic agonists/antagonists.

  35. Erratum: Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor (RSC Chemical Biology (2021) DOI: 10.1039/d0cb00204f) Peer-reviewed

    Kaho Suzuki, Yousuke Takaoka, Minoru Ueda

    RSC Chemical Biology 2 (2) 669 2021/04/01

    Publisher: Royal Society of Chemistry

    DOI: 10.1039/d1cb90002a  

    ISSN: 2633-0679

  36. Syntheses of dinor-cis/iso-12-oxo-phytodienoic acid (dn-cis/iso-OPDAs), ancestral jasmonate phytohormones of the bryophyte Marchantia polymorpha L., and their catabolites Peer-reviewed

    Jianxin Wang, Haruka Sakurai, Nobuki Kato, Takuya Kaji, Minoru Ueda

    Scientific Reports 11 (1) 2021/01/21

    Publisher: Springer Science and Business Media LLC

    DOI: 10.1038/s41598-021-81575-z  

    eISSN: 2045-2322

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    Abstract In recent years, the biology of the evolutionary origin of phytohormone signaling has made significant progress. Among them, the ligand-receptor co-evolution found in jasmonate signaling has attracted the attention of plant scientists. Dinor-cis-12-oxo-phytodienoic acid (dn-cis-OPDA, 4) and dn-iso-OPDA (5) are ancestral plant hormones of the bryophyte Marchantia polymorpha L. We succeeded in the first practical synthetic supply of these hormones as well as their possible catabolites. These compounds are expected to be useful in the study of ancestral jasmonate signaling in bryophytes.

  37. Deciphering OPDA Signaling Components in the Momilactone-Producing Moss Calohypnum plumiforme. International-journal Peer-reviewed

    Hideo Inagaki, Koji Miyamoto, Noriko Ando, Kohei Murakami, Koki Sugisawa, Shion Morita, Emi Yumoto, Miyu Teruya, Kenichi Uchida, Nobuki Kato, Takuya Kaji, Yousuke Takaoka, Yuko Hojo, Tomonori Shinya, Ivan Galis, Akira Nozawa, Tatsuya Sawasaki, Hideaki Nojiri, Minoru Ueda, Kazunori Okada

    Frontiers in plant science 12 688565-688565 2021

    DOI: 10.3389/fpls.2021.688565  

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    Jasmonic acid (JA) and its biologically active form jasmonoyl-L-isoleucine (JA-Ile) regulate defense responses to various environmental stresses and developmental processes in plants. JA and JA-Ile are synthesized from α-linolenic acids derived from membrane lipids via 12-oxo-phytodienoic acid (OPDA). In the presence of JA-Ile, the COI1 receptor physically interacts with JAZ repressors, leading to their degradation, resulting in the transcription of JA-responsive genes by MYC transcription factors. Although the biosynthesis of JA-Ile is conserved in vascular plants, it is not recognized by COI1 in bryophytes and is not biologically active. In the liverwort Marchantia polymorpha, dinor-OPDA (dn-OPDA), a homolog of OPDA with two fewer carbons, and its isomer dn-iso-OPDA accumulate after wounding and are recognized by COI1 to activate downstream signaling. The moss Calohypnum plumiforme produces the antimicrobial-specialized metabolites, momilactones. It has been reported that JA and JA-Ile are not detected in C. plumiforme and that OPDA, but not JA, can induce momilactone accumulation and the expression of these biosynthetic genes, suggesting that OPDA or its derivative is a biologically active molecule in C. plumiforme that induces chemical defense. In the present study, we investigated the biological functions of OPDA and its derivatives in C. plumiforme. Searching for the components potentially involving oxylipin signaling from transcriptomic and genomic data revealed that two COI1, three JAZ, and two MYC genes were present. Quantification analyses revealed that OPDA and its isomer iso-OPDA accumulated in larger amounts than dn-OPDA and dn-iso-OPDA after wounding. Moreover, exogenously applied OPDA, dn-OPDA, or dn-iso-OPDA induced the transcription of JAZ genes. These results imply that OPDA, dn-OPDA, and/or their isomers potentially act as biologically active molecules to induce the signaling downstream of COI1-JAZ. Furthermore, co-immunoprecipitation analysis showed the physical interaction between JAZs and MYCs, indicating the functional conservation of JAZs in C. plumiforme with other plants. These results suggest that COI1-JAZ-MYC mediated signaling is conserved and functional in C. plumiforme.

  38. Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor Peer-reviewed

    Kaho Suzuki, Yousuke Takaoka, Minoru Ueda

    RSC Chemical Biology 2 (2) 499-502 2021

    Publisher: Royal Society of Chemistry (RSC)

    DOI: 10.1039/d0cb00204f  

    eISSN: 2633-0679

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    <p>A rationally designed stapled JAZ peptide selectively inhibited MYCs, master-regulators of the jasmonate signaling in <italic>Arabidopsis thaliana</italic>. It is proposed as a novel chemical tool for the analysis of MYC related jasmonate signaling.</p>

  39. Hoechst-tagged Fluorescein Diacetate for the Fluorescence Imaging-based Assessment of Stomatal Dynamics in Arabidopsis thaliana Peer-reviewed

    Yousuke Takaoka, Saki Miyagawa, Akinobu Nakamura, Syusuke Egoshi, Shinya Tsukiji, Minoru Ueda

    Scientific Reports 10 (1) 2020/12

    Publisher: Springer Science and Business Media LLC

    DOI: 10.1038/s41598-020-62239-w  

    eISSN: 2045-2322

  40. Stereoselective Syntheses of all the Possible Stereoisomers of Coronafacic Acid Peer-reviewed

    Raku Watanabe, Nobuki Kato, Kengo Hayashi, Sho Tozawa, Yusuke Ogura, Shigefumi Kuwahara, Minoru Ueda

    ChemistryOpen 9 (10) 1008-1017 2020/10/01

    DOI: 10.1002/open.202000210  

    eISSN: 2191-1363

  41. A scalable synthesis of (+)-coronafacic acid Peer-reviewed

    Nobuki Kato, Saki Miyagawa, Haruna Nomoto, Misuzu Nakayama, Makoto Iwashita, Minoru Ueda

    Chirality 32 (4) 423-430 2020/04

    DOI: 10.1002/chir.23172  

    ISSN: 0899-0042

    eISSN: 1520-636X

  42. A Fluorescence Anisotropy-Based Comprehensive Method for the In Vitro Screening of COI1–JAZs Agonists and Antagonists Peer-reviewed

    Yousuke Takaoka, Kengo Hayashi, Kaho Suzuki, Ika Nurul Azizah, Minoru Ueda

    Methods in Molecular Biology 2085 145-160 2020

    DOI: 10.1007/978-1-0716-0142-6_11  

    ISSN: 1064-3745

    eISSN: 1940-6029

  43. Plant nyctinasty – who will decode the ‘Rosetta Stone’? International-journal Peer-reviewed

    Minoru Ueda, Yasuhiro Ishimaru, Yusuke Takeuchi, Yuki Muraoka

    New Phytologist 223 (1) 107-112 2019/07

    Publisher: Wiley

    DOI: 10.1111/nph.15717  

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    Nyctinasty is the circadian rhythmic nastic movement of leguminous plants in response to the onset of darkness, a unique and intriguing phenomenon that has attracted attention for centuries. The movement itself is caused by the asymmetric volume change of motor cells between the adaxial and abaxial sides of the leaflet. Recently, we identified the ion channels responsible for the volume change of motor cells during the leaf-opening process of Samanea saman; the asymmetric expression of SsSLAH1, which is under the control of SsCCA1, was found to play a key role in this process. Here, we summarize the history of the study of nyctinasty, our current results and several insights for further study.

  44. A comprehensive in vitro fluorescence anisotropy assay system for screening ligands of the jasmonate COI1–JAZ co-receptor in plants Peer-reviewed

    Yousuke Takaoka, Keina Nagumo, Ika Nurul Azizah, Saki Oura, Mana Iwahashi, Nobuki Kato, Minoru Ueda

    Journal of Biological Chemistry 294 (13) jbc.RA118.006639-5081 2019/03

    DOI: 10.1074/jbc.RA118.006639  

    ISSN: 0021-9258

    eISSN: 1083-351X

  45. Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect Peer-reviewed

    Satoru Tamura, Maiko Okada, Shigeaki Kato, Yasuharu Shinoda, Norifumi Shioda, Kohji Fukunaga, Kumiko Ui-Tei, Minoru Ueda

    Scientific Reports 8 (1) 2018/12

    Publisher: Springer Science and Business Media LLC

    DOI: 10.1038/s41598-018-20663-z  

    eISSN: 2045-2322

  46. Jasmonic Acid Inhibits Auxin-Induced Lateral Rooting Independently of the CORONATINE INSENSITIVE1 Receptor Peer-reviewed

    Yasuhiro Ishimaru, Kengo Hayashi, Takeshi Suzuki, Hidehiro Fukaki, Justyna Prusinska, Christian Meester, Mussa Quareshy, Syusuke Egoshi, Hideyuki Matsuura, Kosaku Takahashi, Nobuki Kato, Erich Kombrink, Richard M. Napier, Ken-ichiro Hayashi, Minoru Ueda

    Plant Physiology 177 (4) 1704-1716 2018/06/22

    Publisher: Oxford University Press (OUP)

    DOI: 10.1104/pp.18.00357  

    ISSN: 0032-0889

    eISSN: 1532-2548

  47. N-myristoylation and S-acylation are common modifications of Ca2+-regulated Arabidopsis kinases and are required for activation of the SLAC1 anion channel Peer-reviewed

    Shunya Saito, Shin Hamamoto, Koko Moriya, Aiko Matsuura, Yoko Sato, Jun Muto, Hiroto Noguchi, Seiji Yamauchi, Yuzuru Tozawa, Minoru Ueda, Kenji Hashimoto, Philipp Köster, Qiuyan Dong, Katrin Held, Jörg Kudla, Toshihiko Utsumi, Nobuyuki Uozumi

    New Phytologist 218 (4) 1504-1521 2018/06/01

    Publisher: Blackwell Publishing Ltd

    DOI: 10.1111/nph.15053  

    ISSN: 1469-8137 0028-646X

  48. The alkyne-tag Raman imaging of coronatine, a plant pathogen virulence factor, in: Commelina communis and its possible mode of action Peer-reviewed

    Minoru Ueda, Kengo Hayashi, Syusuke Egoshi, Yasuhiro Ishimaru, Yousuke Takaoka, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka

    Organic and Biomolecular Chemistry 16 (18) 3348-3352 2018

    Publisher: Royal Society of Chemistry

    DOI: 10.1039/c8ob00097b  

    ISSN: 1477-0520

  49. Dimerization of GTR1 regulates their plasma membrane localization Peer-reviewed

    Yasuhiro Ishimaru, Kento Washiyama, Takaya Oikawa, Shin Hamamoto, Nobuyuki Uozumi, Minoru Ueda

    Plant Signaling and Behavior 12 (6) 2017/06/03

    Publisher: Taylor and Francis Inc.

    DOI: 10.1080/15592324.2017.1334749  

    ISSN: 1559-2324 1559-2316

  50. Reactive group-embedded affinity labeling reagent for efficient intracellular protein labeling Peer-reviewed

    Yousuke Takaoka, Yuuki Nukadzuka, Minoru Ueda

    Bioorganic & Medicinal Chemistry 25 (11) 2888-2894 2017/06

    DOI: 10.1016/j.bmc.2017.02.059  

    ISSN: 0968-0896

    eISSN: 1464-3391

  51. Design and synthesis of a second-generation ligand-tethered calcium indicator for plant cell biology based on the fundamental analyses of the structure and physical property Peer-reviewed

    Yousuke Takaoka, Masaki Imai, Miyuki Shigenaga, Minoru Ueda

    Tetrahedron 73 (21) 3079-3085 2017/05

    DOI: 10.1016/j.tet.2017.04.023  

    ISSN: 0040-4020

  52. The plant cell-wall enzyme AtXTH3 catalyses covalent cross-linking between cellulose and cello-oligosaccharide Peer-reviewed

    Naoki Shinohara, Naoki Sunagawa, Satoru Tamura, Ryusuke Yokoyama, Minoru Ueda, Kiyohiko Igarashi, Kazuhiko Nishitani

    Scientific Reports 7 (1) 2017/04/26

    DOI: 10.1038/srep46099  

    ISSN: 2045-2322

    eISSN: 2045-2322

  53. A Novel Nuclear Receptor Ligand, Digoxigenin, is a Selective Antagonist of Liver-X-receptors Peer-reviewed

    Haruka Oishi, Yousuke Takaoka, Tomoko Nishimaki-Mogami, Hiroaki Saito, Minoru Ueda

    Chemistry Letters 46 (3) 313-314 2017/03/05

    DOI: 10.1246/cl.161071  

    ISSN: 0366-7022

    eISSN: 1348-0715

  54. GTR1 is a jasmonic acid and jasmonoyl-L-isoleucine transporter in Arabidopsis thaliana Peer-reviewed

    Yasuhiro Ishimaru, Takaya Oikawa, Takeshi Suzuki, Syohei Takeishi, Hideyuki Matsuura, Kosaku Takahashi, Shin Hamamoto, Nobuyuki Uozumi, Takafumi Shimizu, Mitsunori Seo, Hiroyuki Ohta, Minoru Ueda

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 81 (2) 249-255 2017/02

    DOI: 10.1080/09168451.2016.1246174  

    ISSN: 0916-8451

    eISSN: 1347-6947

  55. Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots Peer-reviewed

    Takanori Kobayashi, Reiko Nakanishi Itai, Takeshi Senoura, Takaya Oikawa, Yasuhiro Ishimaru, Minoru Ueda, Hiromi Nakanishi, Naoko K. Nishizawa

    PLANT MOLECULAR BIOLOGY 91 (4-5) 533-547 2016/07

    DOI: 10.1007/s11103-016-0486-3  

    ISSN: 0167-4412

    eISSN: 1573-5028

  56. Protein ligand-tethered synthetic calcium indicator for localization control and spatiotemporal calcium imaging in plant cells Peer-reviewed

    Yousuke Takaoka, Miyuki Shigenaga, Masaki Imai, Yuuki Nukadzuka, Yasuhiro Ishimaru, Kei Saito, Ryusuke Yokoyama, Kazuhiko Nishitani, Minoru Ueda

    Bioorganic & Medicinal Chemistry Letters 26 (1) 9-14 2016/01

    DOI: 10.1016/j.bmcl.2015.11.055  

    ISSN: 0960-894X

    eISSN: 1464-3405

  57. Dual function of coronatine as a bacterial virulence factor against plants: possible COI1–JAZ-independent role Peer-reviewed

    Syusuke Egoshi, Yousuke Takaoka, Hiroaki Saito, Yuuki Nukadzuka, Kengo Hayashi, Yasuhiro Ishimaru, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka, Minoru Ueda

    RSC Advances 6 (23) 19404-19412 2016

    DOI: 10.1039/c5ra20676f  

    ISSN: 2046-2069

    eISSN: 2046-2069

  58. Iron deficiency regulated OsOPT7 is essential for iron homeostasis in rice Peer-reviewed

    Khurram Bashir, Yasuhiro Ishimaru, Reiko Nakanishi Itai, Takeshi Senoura, Michiko Takahashi, Gynheung An, Takaya Oikawa, Minoru Ueda, Aiko Sato, Nobuyuki Uozumi, Hiromi Nakanishi, Naoko K. Nishizawa

    PLANT MOLECULAR BIOLOGY 88 (1-2) 165-176 2015/05

    DOI: 10.1007/s11103-015-0315-0  

    ISSN: 0167-4412

    eISSN: 1573-5028

  59. Elevated Levels of CYP94 Family Gene Expression Alleviate the Jasmonate Response and Enhance Salt Tolerance in Rice Peer-reviewed

    Ken-ichi Kurotani, Kenji Hayashi, Saki Hatanaka, Yosuke Toda, Daisuke Ogawa, Hiroaki Ichikawa, Yasuhiro Ishimaru, Ryo Tashita, Takeshi Suzuki, Minoru Ueda, Tsukaho Hattori, Shin Takeda

    Plant and Cell Physiology 56 (4) 779-789 2015/03/03

    DOI: 10.1093/pcp/pcv006  

    ISSN: 0032-0781

    eISSN: 1471-9053

  60. Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity Peer-reviewed

    Minoru Ueda, Gangqiang Yang, Yuuki Nukadzuka, Yasuhiro Ishimaru, Satoru Tamura, Yoshiyuki Manabe

    ORGANIC & BIOMOLECULAR CHEMISTRY 13 (1) 55-58 2015/01

    DOI: 10.1039/c4ob02106a  

    ISSN: 1477-0520

    eISSN: 1477-0539

  61. 植物の生体機能を制御する分子とその作用機構

    上田 実, 江越 脩祐

    ファルマシア 50 (11) 1081-1085 2014

    Publisher: 公益社団法人 日本薬学会

    DOI: 10.14894/faruawpsj.50.11_1081  

    More details Close

    植物の酸化脂質類(オキシリピン)は,植物における様々な防御応答に重要な役割を果たしている.特に,植物ホルモンとして知られるジャスモン酸類は,植物が食草昆虫の幼虫に食害された際に生産される防御応答物質として知られている. 本稿では,ジャスモン酸誘導体であるジャスモン酸グルコシド,ならびにコロナチンにおいて,近年発見された新たな生体機能制御分子としての役割について述べたい.

  62. Chemical studies on nyctinastic leaf-movements and trap-snapping of Venus's flytrap(The JSCRP Award,The Society Awards Lecture)

    Ueda Minoru

    Regulation of Plant Growth & Development 49 (1) 1-9 2014

    Publisher: The Japanese Society for Chemical Regulation of Plants

    DOI: 10.18978/jscrp.49.1_1  

    ISSN: 1346-5406

    More details Close

    <p>Chemical aspects of the circadian leaf movement known as nyctinasty are discussed in this article. Each of nyctinastic plants of five different genera so far examined contained a pair of factors, one of which induces leaf closure and another induces leaf opening. The relative contents of the closing and opening factors changed correlating with the nyctinastic leaf movement. We focused on the leaf-closing chemical factor, jasmonic acid glucoside (JAG), for bioorganic studies on nyctinasty in Samanea saman. Use of fluorescence-labeled and photoaffinity-labeled factors revealed that JAG targeted extensor motor cells in pulvinus and bound to a membrane target protein on the cells. Another function of JAG as a trap-closing chemical factor of Dionaea muscipula is also described.</p>

  63. Synthesis of Methyl epi-Anhydroquinate Utilizing [2,3]-Sigmatropic Rearrangement of Iodosoalkene Peer-reviewed

    Sho Inomata, Minoru Ueda, Takeshi Sugai, Mitsuru Shoji

    CHEMISTRY LETTERS 42 (10) 1273-1275 2013/10

    DOI: 10.1246/cl.130612  

    ISSN: 0366-7022

    eISSN: 1348-0715

  64. Fabrication of Pure Nanodrugs of Podophyllotoxin Dimer and Their Anticancer Activity Peer-reviewed

    Yoshikazu Ikuta, Yoshitaka Koseki, Tatsuya Murakami, Minoru Ueda, Hidetoshi Oikawa, Hitoshi Kasai

    CHEMISTRY LETTERS 42 (8) 900-901 2013/08

    DOI: 10.1246/cl.130224  

    ISSN: 0366-7022

    eISSN: 1348-0715

  65. Stereoselective construction of cis-decalin framework via radical domino cyclization Peer-reviewed

    Eriko Suzuki, Minoru Ueda, Shigeru Ohba, Takeshi Sugai, Mitsuru Shoji

    TETRAHEDRON LETTERS 54 (12) 1589-1592 2013/03

    DOI: 10.1016/j.tetlet.2013.01.050  

    ISSN: 0040-4039

  66. Triazoyl-phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside Peer-reviewed

    Satoru Tamura, Sho Inomata, Makoto Ebine, Takahisa Genji, Izumi Iwakura, Makoto Mukai, Mitsuru Shoji, Takeshi Sugai, Minoru Ueda

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23 (1) 188-193 2013/01

    DOI: 10.1016/j.bmcl.2012.10.124  

    ISSN: 0960-894X

  67. Hybrid stereoisomers of a compact molecular probe based on a jasmonic acid glucoside: Syntheses and biological evaluations Peer-reviewed

    Minoru Ueda, Gangqiang Yang, Yasuhiro Ishimaru, Tetsuya Itabashi, Satoru Tamura, Hiromasa Kiyota, Shigefumi Kuwahara, Sho Inomata, Mitsuru Shoji, Takeshi Sugai

    BIOORGANIC & MEDICINAL CHEMISTRY 20 (19) 5832-5843 2012/10

    DOI: 10.1016/j.bmc.2012.08.003  

    ISSN: 0968-0896

  68. Creation of Pure Nanodrugs and Their Anticancer Properties Peer-reviewed

    Hitoshi Kasai, Tatsuya Murakami, Yoshikazu Ikuta, Yoshitaka Koseki, Koichi Baba, Hidetoshi Oikawa, Hachiro Nakanishi, Masahiro Okada, Mitsuru Shoji, Minoru Ueda, Hiroshi Imahori, Mitsuru Hashida

    Angewandte Chemie International Edition 51 (41) 10315-10318 2012/09/11

    DOI: 10.1002/anie.201204596  

    ISSN: 1433-7851

  69. Chemical Biology of Natural Products on the Basis of Identification of Target Proteins Peer-reviewed

    Minoru Ueda

    Chemistry Letters 41 (7) 658-666 2012/07/05

    DOI: 10.1246/cl.2012.658  

    ISSN: 0366-7022

    eISSN: 1348-0715

  70. Regulatory mechanism of plant nyctinastic movement: An ion channel-related plant behavior Peer-reviewed

    Yasuhiro Ishimaru, Shin Hamamoto, Nobuyuki Uozumi, Minoru Ueda

    Plant Electrophysiology: Signaling and Responses 125-142 2012/02/01

    Publisher: Springer-Verlag Berlin Heidelberg

    DOI: 10.1007/978-3-642-29110-4_5  

  71. Cassia obtusifolia MetE as a Cytosolic Target for Potassium Isolespedezate, a Leaf-Opening Factor of Cassia plants: Target Exploration by a Compact Molecular-Probe Strategy Peer-reviewed

    Minoru Ueda, Yoshiyuki Manabe, Yuki Otsuka, Nobuyuki Kanzawa

    Chemistry - An Asian Journal 6 (12) 3286-3297 2011/08/03

    DOI: 10.1002/asia.201100392  

    ISSN: 1861-4728

  72. The high performance of 3XFLAG for target purification of a bioactive metabolite: A tag combined with a highly effective linker structure Peer-reviewed

    Minoru Ueda, Yoshiyuki Manabe, Makoto Mukai

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21 (5) 1359-1362 2011/03

    DOI: 10.1016/j.bmcl.2011.01.038  

    ISSN: 0960-894X

  73. "Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound Peer-reviewed

    Yoko Nakamura, Sho Inomata, Makoto Ebine, Yoshiyuki Manabe, Izumi Iwakura, Minoru Ueda

    ORGANIC & BIOMOLECULAR CHEMISTRY 9 (1) 83-85 2011

    DOI: 10.1039/c0ob00843e  

    ISSN: 1477-0520

  74. Trap-Closing Chemical Factors of the Venus Flytrap (Dionaea muscipulla Ellis) Peer-reviewed

    Minoru Ueda, Takashi Tokunaga, Masahiro Okada, Yoko Nakamura, Noboru Takada, Rie Suzuki, Katsuhiko Kondo

    ChemBioChem 11 (17) 2378-2383 2010/10/20

    DOI: 10.1002/cbic.201000392  

    ISSN: 1439-4227

  75. Azido-Coronatine: A Useful Platform for "Click Chemistry"-Mediated Probe Synthesis for Bioorganic Studies Peer-reviewed

    Masahiro Okada, Syuusuke Egoshi, Minoru Ueda

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 74 (10) 2092-2095 2010/10

    DOI: 10.1271/bbb.100518  

    ISSN: 0916-8451

    eISSN: 1347-6947

  76. FLAG tagging by CuAAC and nanogram-scale purification of the target protein for a bioactive metabolite involved in circadian rhythmic leaf movement in Leguminosae Peer-reviewed

    Yoshiyuki Manabe, Makoto Mukai, Satoko Ito, Nobuki Kato, Minoru Ueda

    Chem. Commun. 46 (3) 469-471 2010

    DOI: 10.1039/b915843j  

    ISSN: 1359-7345

    eISSN: 1364-548X

  77. Recent Advances on Bioorganic Chemistry of Plant Metabolites Controlling Nyctinasty Peer-reviewed

    Yoko Nakamura, Yoshiyuki Manabe, Sho Inomata, Minoru Ueda

    CHEMICAL RECORD 10 (2) 70-79 2010

    DOI: 10.1002/tcr.200900021  

    ISSN: 1527-8999

  78. Plant Phenolic Compounds Controlling Leaf Movement Peer-reviewed

    Minoru Ueda, Yoko Nakamura

    RECENT ADVANCES IN POLYPHENOL RESEARCH, VOL 2 2 226-237 2010

    DOI: 10.1002/9781444323375.ch8  

  79. Recent Advances on the Target Protein of Bioactive Metabolite Controlling Nyctinasty Peer-reviewed

    Y. Nakamura, Y. Manabe, S. Inomata, M. Ueda

    The Chemical Record 2010

    DOI: 10.1002/tcr.200900021  

  80. マメ科植物の就眠運動を制御する配糖体型生理活性物質のケミカルバイオロジー Peer-reviewed

    真鍋良幸, 猪俣 翔, 上田 実

    TIGG Review 2010

  81. ジャスミンの香気成分誘導体と植物の就眠運動 Peer-reviewed

    上田 実, 中村葉子

    AROMA RESEARCH 2010

  82. Chemical Biology of Glycoside-Type Bioactive Substances Controlling Nyctinastic Movement in Leguminous Plants Peer-reviewed

    Yoshiyuki Manabe, Sho Inomata, Minoru Ueda

    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 22 (123-24) 16-25 2010/01

    DOI: 10.452/tigg.22.16  

    ISSN: 0915-7352

  83. A Target Protein for Potassium Isolespedezate, A Bioactive Metabolite Controlling Nyctinasty

    Yoshiyuki Manabe, Izumi Iwakura, Makoto Mukai, Minoru Ueda

    Interdisciplinary Bio Central 1 (4) 1-5 2009/11/22

    Publisher: Korean Society for Bioinformatics and Systems Biology

    DOI: 10.4051/ibc.2009.4.0014  

    ISSN: 2005-8543

  84. Total Syntheses of Coronatines by Exo-selective Diels-Alder Reaction and Their Biological Activities on Stomatal Opening

    Okada Masahiro, Egoshi Syusuke, Ito Satoko, Matsubara Akira, Ueda Minoru

    Symposium on the Chemistry of Natural Products, symposium papers (51) 455-460 2009/09/01

    Publisher: Symposium on the chemistry of natural products

    DOI: 10.24496/tennenyuki.51.0_455  

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    The natural phytotoxin coronatine, which is composed of two individual parts, coronafacic acid and coronamic acid, exhibits various promising biological activities similar to jasmonic acid, which is noe of the phytohormones. Interstingly, coronatine induces stomatal opening involving the swelling of guard cells in which jasmonic acid is not involved as an endogenous regulator. In order to apply the enantiodifferential approach for the identification of its target protein, we established syntheses of four stereoisomers of coronatine employing the exo-selectie Diels-Alder reaction as a key step. It will be advantageous to go through versatile intermediate for the preparation of various derivatives. Remarkable differences in a stomatal opening activity were observed between enantiomers of coronatine. This result strongly suggests that the stereostructure of coronatine is so important for its stomatal opening activity. In addition, structure-activity relationship studies suggested that coronatine operates as a molecular mimic of jasmonyl-L-isoleucine in plant guard celld. We also synthesized coronatine azide according to our synthetic strategy of coronatine, which possessed potent stomatal opening activity.

  85. Total Synthesis of (+/-)-5-Deoxystrigol via Reductive Carbon-Carbon Bond Formation Peer-reviewed

    Mitsuru Shoji, Eriko Suzuki, Minoru Ueda

    JOURNAL OF ORGANIC CHEMISTRY 74 (10) 3966-3969 2009/05

    DOI: 10.1021/jo9002085  

    ISSN: 0022-3263

  86. Chemical Signaling during Induced Leaf Movements, in Frantisek Baluska eds. Invited Peer-reviewed

    M. Ueda, Y. Nakamura

    Plant-Environment Interactions 2009/05

  87. 植物生理活性物質のケミカルジェネティックス Invited Peer-reviewed

    上田 実, 中村葉子, 真鍋良幸

    細胞工学 28 (4) 354-359 2009/04

    Publisher:

    ISSN: 0287-3796

  88. (R)-Eucomic acid, a leaf-opening factor of the model organism, Lotus japonicus Peer-reviewed

    Masahiro Okada, Sungwook Park, Takahiro Koshizawa, Minoru Ueda

    TETRAHEDRON 65 (10) 2136-2141 2009/03

    DOI: 10.1016/j.tet.2008.11.097  

    ISSN: 0040-4020

  89. 不思議な生物現象の有機化学­­–植物の就眠運動を化学する Invited Peer-reviewed

    上田 実, 中村葉子

    化学と教育 57 (3) 134-135 2009/03

    Publisher:

    DOI: 10.20665/kakyoshi.57.3_134  

    ISSN: 0386-2151

  90. 植物就眠運動のケミカルバイオロジー Invited Peer-reviewed

    上田 実, 中村葉子

    化学と生物 47 (2) 121-127 2009/02

    Publisher:

    DOI: 10.1271/kagakutoseibutsu.47.121  

    ISSN: 0453-073X

  91. Plant Phenolic Compounds Controlling Leaf-movement, in F.Daayf and V. Lattanzio eds. Invited Peer-reviewed

    M. Ueda, Y. Nakamura

    Recent Advances in Polyphenol Research 2009/02

  92. Total syntheses of coronatines by exo-selective Diels–Alder reaction and their biological activities on stomatal opening Peer-reviewed

    Masahiro Okada, Satoko Ito, Akira Matsubara, Izumi Iwakura, Syusuke Egoshi, Minoru Ueda

    Organic & Biomolecular Chemistry 7 (15) 3065-3065 2009

    DOI: 10.1039/b905159g  

    ISSN: 1477-0520

    eISSN: 1477-0539

  93. Synthesis and Bioactivity of Potassium beta-D-Glucopyranosyl 12-Hydroxy Jasmonate and Related Compounds Peer-reviewed

    Yoko Nakamura, Ryoji Miyatake, Sho Inomata, Minoru Ueda

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 72 (11) 2867-2876 2008/11

    DOI: 10.1271/bbb.80338  

    ISSN: 0916-8451

    eISSN: 1347-6947

  94. 植物の就眠運動と食虫植物の”記憶”現象の生物有機化学 Invited Peer-reviewed

    上田 実, 中村葉子, 岡田正弘

    植物の生長調節 42 (1) 61-71 2008/06/10

    Publisher: The Japanese Society for Chemical Regulation of Plants

    DOI: 10.18978/jscrp.43.1_61  

    ISSN: 1346-5406

  95. Synthesis of photoaffinity probe based on the leaf-opening factor from genus Albizzia Peer-reviewed

    Masahiro Okada, Akira Matsubara, Minoru Ueda

    TETRAHEDRON LETTERS 49 (23) 3794-3796 2008/06

    DOI: 10.1016/j.tetlet.2008.04.002  

    ISSN: 0040-4039

  96. ここまでわかった「動く植物」の謎 Invited

    中村葉子, 真鍋良幸, 上田 実

    化学 63 (5) 26-31 2008/04/30

  97. Affinity purification and characterization of a key enzyme responsible for circadian rhythmic control of nyctinasty in Lespedeza cuneata L. Peer-reviewed

    Eisuke Kato, Takehiko Sasaki, Minoru Ueda

    BIOORGANIC & MEDICINAL CHEMISTRY 16 (8) 4600-4616 2008/04

    DOI: 10.1016/j.bmc.2008.02.035  

    ISSN: 0968-0896

    eISSN: 1464-3391

  98. Synthesis of staudinger-type molecular probe for catch-and-release purification of the binding protein for potassium isolespedezate, a leaf-closing substance of leguminous plant Peer-reviewed

    Tomohiko Fujii, Nobuki Kato, Izumi Iwakura, Yoshiyuki Manabe, Minoru Ueda

    CHEMISTRY LETTERS 37 (1) 52-53 2008/01

    DOI: 10.1246/cl.2008.52  

    ISSN: 0366-7022

    eISSN: 1348-0715

  99. Synthesis of staudinger-type molecular probe for catch-and-release purification of the binding protein for potassium isolespedezate, a leaf-closing substance of leguminous plant Peer-reviewed

    Tomohiko Fujii, Nobuki Kato, Izumi Iwakura, Yoshiyuki Manabe, Minoru Ueda

    CHEMISTRY LETTERS 37 (1) 52-53 2008/01

    DOI: 10.1246/cl.2008.52  

    ISSN: 0366-7022

    eISSN: 1348-0715

  100. Enantio-differential approach using fluorescence-labeled phyllanthurinolactone, a leaf-closing factor of Phyllanthus urinaria L. Peer-reviewed

    Nobuki Kato, Masayoshi Inada, Hirotaka Sato, Satoko Ito, Mitsuru Shoji, Minoru Ueda

    TETRAHEDRON LETTERS 48 (43) 7702-7705 2007/10

    DOI: 10.1016/j.tetlet.2007.08.058  

    ISSN: 0040-4039

  101. 植物のリズム運動を制御する生理活性天然物のケミカルバイオロジー Invited Peer-reviewed

    上田 実, 中村葉子, 岡田正弘

    蛋白質・核酸・酵素別冊「ケミカルバイオロジー」(2007). 52 (13) 1667-1672,1507〜1508 2007/10/01

    Publisher:

    ISSN: 0039-9450

  102. 植物の外部シグナルセンシング:就眠運動と刺激の記憶 Invited Peer-reviewed

    上田 実, 中村葉子, 岡田正弘

    細胞工学「感覚センサー:生物の感覚機能の驚くべき多様性にせまる、そして応用へ」 26 898-902 2007/07/25

  103. Chemical Basis of Plant Leaf Movement Peer-reviewed

    M. Ueda, Y. Nakamura

    Plant and Cell Physiology 48 (7) 900-907 2007/06/13

    DOI: 10.1093/pcp/pcm060  

    ISSN: 0032-0781

    eISSN: 1471-9053

  104. Endogenous factors involved in the regulation of movement and "memory" in plants Invited Peer-reviewed

    Minoru Ueda, Yoko Nakamura, Masahiro Okada

    PURE AND APPLIED CHEMISTRY 79 (4) 519-527 2007/04

    DOI: 10.1351/pac200779040519  

    ISSN: 0033-4545

  105. 植物の就眠運動と食虫植物の”記憶”現象の生物有機化学 Invited Peer-reviewed

    上田 実, 中村葉子, 岡田正弘

    植物の生長調節 43 (1) 61-71 2007/04/01

    Publisher: The Japanese Society for Chemical Regulation of Plants

    DOI: 10.18978/jscrp.43.1_61  

    ISSN: 1346-5406

  106. Affinity purification of the key enzyme of nyctinasty controlling the rhythm of leaf movement using gluconamidine ligand Peer-reviewed

    Eisuke Kato, Takehiko Sasaki, Tadahiro Kumagai, Minoru Ueda

    TETRAHEDRON LETTERS 48 (13) 2409-2413 2007/03

    DOI: 10.1016/j.tetlet.2007.01.085  

    ISSN: 0040-4039

  107. Nanometer-scale direct observation of the receptor for the leaf-movement factor in plant cell by a novel TEM probe Peer-reviewed

    Yoshiyuki Manabe, Takanori Sugimoto, Tomoyuki Kawasaki, Minoru Ueda

    TETRAHEDRON LETTERS 48 (8) 1341-1344 2007/02

    DOI: 10.1016/j.tetlet.2006.12.128  

    ISSN: 0040-4039

  108. 就眠運動の化学メカニズム Invited Peer-reviewed

    上田 実, 中村葉子, 真鍋良幸, 岡田正弘

    遺伝 61 28-29 2007/01/10

  109. Enantio-diffferential approach to identify the target cell for glucosyl jasmonate-type leaf-closing factor, by using fluorescence-labeled probe compounds Peer-reviewed

    Yoko Nakamura, Ryoji Miyatake, Akira Matsubara, Hiromasa Kiyota, Minoru Ueda

    TETRAHEDRON 62 (37) 8805-8813 2006/09

    DOI: 10.1016/j.tet.2006.06.092  

    ISSN: 0040-4020

  110. P-37 Fluorescence Studies on the Nyctinasty of Albizzia Plants, An enantio-differential approach Using Enantio-pair of Fluorescence-labeled leaf closing factors

    Nakamura Yoko, Miyatake Ryoji, Kiyota Hiromasa, Ueda Minoru

    International Symposium on the Chemistry of Natural Products 2006 "P-37" 2006/07/23

    Publisher: Symposium on the chemistry of natural products

    DOI: 10.24496/intnaturalprod.2006.0__P-37_  

  111. Fluorescence study on the nyctinasty of Phyllanthus urinaria L. using novel fluorescence-labeled probe compounds Peer-reviewed

    Nobuki Kato, Masayoshi Inada, Hirotaka Sato, Ryoji Miyatake, Tsutomu Kumagai, Minoru Ueda

    TETRAHEDRON 62 (31) 7307-7318 2006/07

    DOI: 10.1016/j.tet.2006.05.022  

    ISSN: 0040-4020

  112. Double fluorescence-labeling study on genus Albizzia using a set of fluorecence-labeled leaf-movement factors to identify the spatial distribution of their receptors Peer-reviewed

    Yoko Nakamura, Akira Matsubara, Masahiro Okada, Tsutomu Kumagai, Minoru Ueda

    CHEMISTRY LETTERS 35 (7) 744-745 2006/07

    DOI: 10.1246/cl.2006.744  

    ISSN: 0366-7022

    eISSN: 1348-0715

  113. ハエトリグサの捕虫運動について Invited

    上田 実

    生物の科学 遺伝 59 (4) 55-60 2006/07/01

  114. 細菌のクオラムセンシングを誘導するフェロモン Invited

    上田 実

    化学 61 (6) 72-73 2006/06/01

  115. Direct observation of the target cell for jasmonate-type leaf-closing factor: genus-specific binding of leaf-movement factors to the plant motor cell Peer-reviewed

    Y Nakamura, H Kiyota, T Kumagai, M Ueda

    TETRAHEDRON LETTERS 47 (17) 2893-2897 2006/04

    DOI: 10.1016/j.tetlet.2006.02.123  

    ISSN: 0040-4039

  116. Bioorganic chemistry of nyctinasty using functional probes Peer-reviewed

    M Ueda, T Fujii, E Kato, T Sugimoto, N Kato

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 64 (2) 117-129 2006/02

    DOI: 10.5059/yukigoseikyokaishi.64.117  

    ISSN: 0037-9980

  117. アフィニティークロマトグラフィー Invited Peer-reviewed

    上田 実

    有機合成化学協会誌 64 172-172 2006/02/01

  118. Synthesis and odor description of both enantiomers of methyl 4,5-didehydrojasmonate, a component of jasmin absolute Peer-reviewed

    Yuko Asamitsu, Yoko Nakamura, Minoru Ueda, Shigefumi Kuwahara, Hiromasa Kiyota

    CHEMISTRY & BIODIVERSITY 3 (6) 654-659 2006

    DOI: 10.1002/cbdv.200690068  

    ISSN: 1612-1872

  119. Bioorganic studies on plant movement, from natural products to its receptor Peer-reviewed

    Mitsuru Shoji, Eisuke Kato, Yoko Nakamura, Tomohiko Fujii, Yoshiyuki Manabe, Minoru Ueda

    CHEMICAL RECORD 6 (6) 344-355 2006

    DOI: 10.1002/tcr.20102  

    ISSN: 1527-8999

  120. Bioorganic chemistry of nyctinasty using functional probes Invited Peer-reviewed

    Minoru Ueda, Tomohiko Fujii, Eisuke Kato, Takanori Sugimoto, Nobuki Kato

    Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 64 (2) 117-129 2006

    Publisher: Society of Synthetic Organic Chemistry

    DOI: 10.5059/yukigoseikyokaishi.64.117  

    ISSN: 0037-9980

  121. Synthesis and odor description of both enantiomers of methyl 4,5-didehydrojasmonate, a component of jasmin absolute Peer-reviewed

    Yuko Asamitsu, Yoko Nakamura, Minoru Ueda, Shigefumi Kuwahara, Hiromasa Kiyota

    CHEMISTRY & BIODIVERSITY 3 (6) 654-659 2006

    DOI: 10.1002/cbdv.200690068  

    ISSN: 1612-1872

  122. Bioorganic studies on plant movement, from natural products to its receptor Invited Peer-reviewed

    Mitsuru Shoji, Eisuke Kato, Yoko Nakamura, Tomohiko Fujii, Yoshiyuki Manabe, Minoru Ueda

    CHEMICAL RECORD 6 (6) 344-355 2006

    DOI: 10.1002/tcr.20102  

    ISSN: 1527-8999

  123. 食虫植物の「記憶」に関与する天然有機化合物 Invited

    上田 実

    化学と工業 58 1037-1038 2005/09/01

  124. Direct observation of a target cell of the leaf-closing factor by using novel fluorescence-labeled phyllanthurinolactone Peer-reviewed

    H Sato, M Inada, T Sugimoto, N Kato, M Ueda

    TETRAHEDRON LETTERS 46 (33) 5537-5541 2005/08

    DOI: 10.1016/j.tetlet.2005.06.044  

    ISSN: 0040-4039

  125. Detection of 210 kDa receptor protein for a leaf-movement factor by using novel photoaffinity probes Peer-reviewed

    T Fujii, Y Manabe, T Sugimoto, M Ueda

    TETRAHEDRON 61 (33) 7874-7893 2005/08

    DOI: 10.1016/j.tet.2005.06.022  

    ISSN: 0040-4020

  126. Direct observation of a target cell of the leaf-closing factor by using novel fluorescence-labeled phyllanthurinolactone Peer-reviewed

    H Sato, M Inada, T Sugimoto, N Kato, M Ueda

    TETRAHEDRON LETTERS 46 (33) 5537-5541 2005/08

    DOI: 10.1016/j.tetlet.2005.06.044  

    ISSN: 0040-4039

  127. Concise synthesis of glyconoamidines as affinity ligands for the purification of beta-glucosidase involved in control of some biological events including plant leaf movement Peer-reviewed

    E Kato, T Kumagai, M Ueda

    TETRAHEDRON LETTERS 46 (29) 4865-4869 2005/07

    DOI: 10.1016/j.tetlet.2005.05.060  

    ISSN: 0040-4039

  128. Concise synthesis of glyconoamidines as affinity ligands for the purification of beta-glucosidase involved in control of some biological events including plant leaf movement Peer-reviewed

    E Kato, T Kumagai, M Ueda

    TETRAHEDRON LETTERS 46 (29) 4865-4869 2005/07

    DOI: 10.1016/j.tetlet.2005.05.060  

    ISSN: 0040-4039

  129. ハエトリソウの「記憶」物質を追って Invited

    上田 実, 徳永隆司, 小関不比等

    現代化学 (423) 52-57 2005/05/01

    Publisher:

    ISSN: 0386-961X

  130. Mechanism of antifeedant activity of plumbagin, a compound concerning the chemical defense in carnivorous plant Peer-reviewed

    T Tokunaga, N Takada, M Ueda

    TETRAHEDRON LETTERS 45 (38) 7115-7119 2004/09

    DOI: 10.1016/j.tetlet.2004.07.094  

    ISSN: 0040-4039

  131. Biomimetic synthesis of a leaf-opening factor, potassium isolespedezate, by direct formation of enol-glycoside Peer-reviewed

    T Sugimoto, M Ueda

    CHEMISTRY LETTERS 33 (8) 976-977 2004/08

    DOI: 10.1246/cl.2004.976  

    ISSN: 0366-7022

    eISSN: 1348-0715

  132. Biomimetic synthesis of a leaf-opening factor, potassium isolespedezate, by direct formation of enol-glycoside Peer-reviewed

    T Sugimoto, M Ueda

    CHEMISTRY LETTERS 33 (8) 976-977 2004/08

    DOI: 10.1246/cl.2004.976  

    ISSN: 0366-7022

    eISSN: 1348-0715

  133. Enantioselective synthesis of phyllanthurinolactone, a leaf-closing substance of Phyllanthus urinaria L., and its analogs toward the development of molecular probes Peer-reviewed

    Y Urakawa, T Sugimoto, H Sato, M Ueda

    TETRAHEDRON LETTERS 45 (30) 5885-5888 2004/07

    DOI: 10.1016/j.tetlet.2004.05.129  

    ISSN: 0040-4039

  134. Cytotoxic antifeedant from Dionaea muscipula Ellis: A defensive mechanism of carnivorous plants against predators Peer-reviewed

    T Tokunaga, A Dohmura, N Takada, M Ueda

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 77 (3) 537-541 2004/03

    DOI: 10.1246/bcsj.77.537  

    ISSN: 0009-2673

    eISSN: 1348-0634

  135. Mechanism of asymmetric decarboxylation of alpha-aryl-alpha-methylmalonate catalyzed by arylmalonate decarboxylase originated from Alcaligenes bronchisepticus Peer-reviewed

    K Matoishi, M Ueda, K Miyamoto, H Ohta

    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 27 (4-6) 161-168 2004/03

    DOI: 10.1016/j.molcatb.2003.11.005  

    ISSN: 1381-1177

  136. Cytotoxic antifeedant from Dionaea muscipula Ellis: A defensive mechanism of carnivorous plants against predators Peer-reviewed

    T Tokunaga, A Dohmura, N Takada, M Ueda

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 77 (3) 537-541 2004/03

    DOI: 10.1246/bcsj.77.537  

    ISSN: 0009-2673

    eISSN: 1348-0634

  137. Mechanism of asymmetric decarboxylation of alpha-aryl-alpha-methylmalonate catalyzed by arylmalonate decarboxylase originated from Alcaligenes bronchisepticus Peer-reviewed

    K Matoishi, M Ueda, K Miyamoto, H Ohta

    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 27 (4-6) 161-168 2004/03

    DOI: 10.1016/j.molcatb.2003.11.005  

    ISSN: 1381-1177

  138. Detection of potential membrane receptor proteins concerning circadian rhythmic leaf movement of legumes using novel photoaffinity probe compounds Peer-reviewed

    T Sugimoto, T Fujii, Y Idutu, S Yamamura, M Ueda

    TETRAHEDRON LETTERS 45 (2) 335-338 2004/01

    DOI: 10.1016/j.tetlet.2003.10.150  

    ISSN: 0040-4039

  139. Albiziahexoside: A potential source of bioactive saponin from the leaves of Albizzia lebbeck Peer-reviewed

    M Ueda, T Tokunaga, M Okazaki, NU Sata, K Ueda, S Yamamura

    NATURAL PRODUCT RESEARCH 17 (5) 329-335 2003/10

    DOI: 10.1080/1057563031000072578  

    ISSN: 1478-6419

  140. Synthetic inhibitor of leaf-closure that reveals the biological importance of leaf-movement for the survival of leguminous plants Peer-reviewed

    Eisuke Kato, Hideharu Nagano, Shosuke Yamamura, Minoru Ueda

    Tetrahedron 59 (31) 5909-5917 2003/07

    DOI: 10.1016/s0040-4020(03)00906-2  

    ISSN: 0040-4020

  141. Fluorescence studies on nyctinasty using fluorescence labeled cis-p-coumaroylagmatine, a leaf-opening substance of Albizzia plants: existence of genus-specific receptor for leaf-movement factor Peer-reviewed

    H Nagano, E Kato, S Yamamura, M Ueda

    TETRAHEDRON LETTERS 44 (14) 2953-2956 2003/03

    DOI: 10.1016/S0040-4039(03)00376-9  

    ISSN: 0040-4039

  142. Synthesis of a novel bioactive photoaffinity probe based on a leaf-movement factor with potential high binding affinity to its receptor molecule Peer-reviewed

    T Fujii, T Sugimoto, S Yamamura, M Ueda

    TETRAHEDRON LETTERS 44 (12) 2497-2499 2003/03

    DOI: 10.1016/S0040-4039(03)00287-9  

    ISSN: 0040-4039

  143. Chemical studies on plant leaf movement controlled by a biological clock Peer-reviewed

    M Ueda, T Sugimoto, Y Sawai, T Ohnuki, S Yamamura

    PURE AND APPLIED CHEMISTRY 75 (2-3) 353-358 2003/02

    ISSN: 0033-4545

  144. Fluorescence studies on nyctinasty which suggest the existence of genus-specific receptors for leaf-movement factor Peer-reviewed

    H Nagano, E Kato, S Yamamura, M Ueda

    ORGANIC & BIOMOLECULAR CHEMISTRY 1 (18) 3186-3192 2003

    DOI: 10.1039/b308764f  

    ISSN: 1477-0520

  145. Synthetic probe compounds for the bioorganic studies of nyctinastic leaf-movement in leguminous plants Peer-reviewed

    T. Sugimoto, T. Fujii, S. Yamamura, M. Ueda

    Trends in Heterocyclic Chemistry 101-107 2003

  146. Diels-Alder反応を触媒する生合成酵素

    上田実

    化学 62-63 2003

  147. Fluorescence studies on nyctinasty which suggest the existence of genus-specific receptors for leaf-movement factor Peer-reviewed

    H Nagano, E Kato, S Yamamura, M Ueda

    ORGANIC & BIOMOLECULAR CHEMISTRY 1 (18) 3186-3192 2003

    DOI: 10.1039/b308764f  

    ISSN: 1477-0520

  148. Vacuolar-type H+ -ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? Peer-reviewed

    Y Yoshimoto, T Jyojima, T Arita, M Ueda, M Imoto, S Matsumura, K Toshima

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12 (24) 3525-3528 2002/12

    DOI: 10.1016/S0960-894X(02)00806-5  

    ISSN: 0960-894X

  149. Visualization of the precise structure recognition of leaf-opening substance by using biologically inactive probe compounds: Fluorescence studies of nyctinasty in legumes 2 Peer-reviewed

    T Sugimoto, S Yamamura, M Ueda

    CHEMISTRY LETTERS (11) 1118-1119 2002/11

    DOI: 10.1246/cl.2002.1118  

    ISSN: 0366-7022

    eISSN: 1348-0715

  150. Bioorganic studies on nyctinasty of the plant controlled by a biological clock Peer-reviewed

    M Ueda, N Takada, S Yamamura

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 75 (11) 2337-2347 2002/11

    DOI: 10.1246/bcsj.75.2337  

    ISSN: 0009-2673

    eISSN: 1348-0634

  151. A novel leaf-movement inhibitor of a nyctinastic weed, Sesbania exaltata Cory, designed on a naturally occurring leaf-opening substance and its application to a potential, highly selective herbicide Peer-reviewed

    Noboru Takada, Eisuke Kato, Katsuhiro Ueda, Shosuke Yamamura, Minoru Ueda

    Tetrahedron Letters 43 (43) 7655-7658 2002/10

    DOI: 10.1016/s0040-4039(02)01848-8  

    ISSN: 0040-4039

  152. The biological significance of leaf-movement, an approach using a synthetic inhibitor of leaf-closure Peer-reviewed

    Minoru Ueda, Takanori Sugimoto, Yoshiyuki Sawai, Shosuke Yamamura

    Tetrahedron Letters 43 (42) 7545-7548 2002/10

    DOI: 10.1016/s0040-4039(02)01770-7  

    ISSN: 0040-4039

  153. Syntheses of novel photoaffinity probes for bioorganic studies on nyctinasty of leguminous plants Peer-reviewed

    T Sugimoto, T Fujii, Y Hatanaka, S Yamamura, M Ueda

    TETRAHEDRON LETTERS 43 (37) 6529-6532 2002/09

    DOI: 10.1016/S0040-4039(02)01460-0  

    ISSN: 0040-4039

  154. Bioorganic chemistry of nyctinastic leaf-movement using synthetic probe compounds Peer-reviewed

    M Ueda, N Takada, S Yamamura

    CURRENT ORGANIC CHEMISTRY 6 (6) 493-505 2002/05

    DOI: 10.2174/1385272024604925  

    ISSN: 1385-2728

  155. Leaf-closing substance in Leucaena leucocephala Peer-reviewed

    Y Sohtome, T Tokunaga, K Ueda, S Yamamura, M Ueda

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 66 (1) 51-56 2002/01

    DOI: 10.1271/bbb.66.51  

    ISSN: 0916-8451

    eISSN: 1347-6947

  156. Bioorganic Studies on Nyctinastic leaf-movement of the Plant Using Synthetic Probe Compounds Peer-reviewed

    M. Ueda, T. Sugimoto, S. Yamamura

    Recent Research Developments in Organic Chemistry 649-662 2002

  157. Recent advances on the bioorganic chemistry of nyctinastic leaf-movement Peer-reviewed

    M. Ueda, N. Takada, S. Yamamura

    Recent Research Developments in Phytochemistry 1-11 2002

  158. 植物の運動を支配する鍵化学物質 Peer-reviewed

    上田 実, 杉本貴謙, 高田 晃, 山村庄亮

    化学と生物 40 (9) 578-584 2002

    Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry

    DOI: 10.1271/kagakutoseibutsu1962.40.578  

    ISSN: 0453-073X

  159. Fluorescence study on the nyctinasty of Cassia mimosoides L. using novel fluorescence-labeled probe compounds Peer-reviewed

    T Sugimoto, Y Wada, S Yamamura, M Ueda

    TETRAHEDRON 57 (49) 9817-9825 2001/12

    DOI: 10.1016/S0040-4020(01)00999-1  

    ISSN: 0040-4020

  160. Direct observation of the target cell for leaf-movement factor using novel fluorescence-labeled probe compounds: Fluorescence studies of nyctinasty in legumes. Part 1 Peer-reviewed

    M Ueda, Y Wada, S Yamamura

    TETRAHEDRON LETTERS 42 (23) 3869-3872 2001/06

    DOI: 10.1016/S0040-4039(01)00589-5  

    ISSN: 0040-4039

  161. Potassium 2,3,4-trihydroxy-2-methylbutanoate, a leaf-closing substance of Leucaena leucocephalam Peer-reviewed

    M Ueda, Y Sohtome, K Ueda, S Yamamura

    TETRAHEDRON LETTERS 42 (17) 3109-3111 2001/04

    DOI: 10.1016/S0040-4039(01)00380-X  

    ISSN: 0040-4039

  162. Molecular approach to the nyctinastic movement of the plant controlled by a biological clock Peer-reviewed

    Minoru Ueda, Noboru Takada, Shosuke Yamamura

    International Journal of Molecular Sciences 2 (4) 156-164 2001

    Publisher: MDPI AG

    DOI: 10.3390/i2040156  

    ISSN: 1422-0067

  163. Migrastatin, a novel 14-membered lactone from Streptomyces sp. MK929-43F1.

    K. Nakae, Y. Yoshimoto, M. Ueda, T. Sawa, Y. Takahashi, H. Naganawa

    J. Antibiot. (53) 1228-1230 (2000) 2000/11

  164. A leaf-closing substance of Albizzia julibrissin Durazz Peer-reviewed

    M Ueda, M Okazaki, K Ueda, S Yamamura

    TETRAHEDRON 56 (41) 8101-8105 2000/10

    DOI: 10.1016/S0040-4020(00)00729-8  

    ISSN: 0040-4020

  165. Synthetic probe compounds for bioorganic studies of nyctinasty, based on the leaf-opening substance of Lespedeza cuneata G. Don Peer-reviewed

    M Ueda, Y Sawai, Y Wada, S Yamamura

    TETRAHEDRON 56 (29) 5123-5130 2000/07

    DOI: 10.1016/S0040-4020(00)00421-X  

    ISSN: 0040-4020

  166. Syntheses of fluorescence-labeled artificial leaf-opening substances, fluorescent probe compounds useful for bioorganic studies of nyctinasty Peer-reviewed

    M Ueda, Y Sawai, S Yamamura

    TETRAHEDRON LETTERS 41 (18) 3433-3436 2000/04

    DOI: 10.1016/S0040-4039(00)00394-4  

    ISSN: 0040-4039

  167. The diversity of chemical substances controlling the nyctinastic leaf-movement in plants Peer-reviewed

    Minoru Ueda, Hideyuki Shigemori, Noriko Sata, Shosuke Yamamura

    Phytochemistry 53 (1) 39-44 2000/01

    DOI: 10.1016/s0031-9422(99)00467-7  

    ISSN: 0031-9422

  168. The chemical control on the leaf-movement of Phyllanthus urinaria L. by the internal balance of concentration between two bioactive substances. Peer-reviewed

    M Ueda, M Asano, Y Sawai, S Yamamura

    NATURAL PRODUCT LETTERS 14 (3) 225-232 2000

    DOI: 10.1080/10575630008041235  

    ISSN: 1057-5634

  169. Bioorganic Studies on Plant Leaf-movement Controlled by a Biological Clock Peer-reviewed

    M. Ueda, S. Yamamura

    Reseach Advances in Phytochemistry 129-136 2000

  170. The isolation of bioactive substance controlling the plant leaf-movement of Albizzia julibrissin Durazz. Peer-reviewed

    M Ueda, S Yamamura

    NATURAL PRODUCT LETTERS 14 (5) 325-331 2000

    DOI: 10.1080/10575630008043764  

    ISSN: 1057-5634

  171. Potassium beta-D-glucopyranosyl 11-hydroxyjasmonate, a leaf-closing substance of Albizzia julibrissin Durazz Peer-reviewed

    M Ueda, S Yamamura

    TETRAHEDRON LETTERS 40 (44) 7823-7826 1999/10

    DOI: 10.1016/S0040-4039(99)01628-7  

    ISSN: 0040-4039

  172. The chemistry of leaf-movement in Mimosa pudica L. Peer-reviewed

    M Ueda, S Yamamura

    TETRAHEDRON 55 (36) 10937-10948 1999/09

    DOI: 10.1016/S0040-4020(99)00619-5  

    ISSN: 0040-4020

  173. Potassium aeshynomate, a leaf-opening substance of Aeshynomene indica L., containing a novel gamma-amino acid Peer-reviewed

    M Ueda, T Hiraoka, M Niwa, S Yamamura

    TETRAHEDRON LETTERS 40 (37) 6777-6780 1999/09

    DOI: 10.1016/S0040-4039(99)01198-3  

    ISSN: 0040-4039

  174. Syntheses and novel bioactivities of artificial leaf-opening substances of Lespedeza cuneata G. Don, designed for the bioorganic studies of nyctinasty Peer-reviewed

    M Ueda, Y Sawai, S Yamamura

    TETRAHEDRON 55 (36) 10925-10936 1999/09

    DOI: 10.1016/S0040-4020(99)00618-3  

    ISSN: 0040-4020

  175. Chemical substances controlling the leaf-movement of the plants: How does biological clock control the plant movement? Peer-reviewed

    M Ueda, S Yamamura

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 57 (7) 571-580 1999/07

    DOI: 10.5059/yukigoseikyokaishi.57.571  

    ISSN: 0037-9980

  176. Sugar-derivatives of potassium lespedezate, artificial leaf-opening substances of Lespedeza cuneata G. Don, designed for the bioorganic studies of nyctinasty Peer-reviewed

    M Ueda, Y Sawai, S Yamamura

    TETRAHEDRON LETTERS 40 (19) 3757-3760 1999/05

    DOI: 10.1016/S0040-4039(99)00602-4  

    ISSN: 0040-4039

  177. Leaf-closing substance of Mimosa pudica L; Chemical studies on another leaf-movement of Mimosa - II Peer-reviewed

    M Ueda, S Yamamura

    TETRAHEDRON LETTERS 40 (15) 2981-2984 1999/04

    DOI: 10.1016/S0040-4039(99)00342-1  

    ISSN: 0040-4039

  178. Leaf-movement factors of nyctinastic plant, Phyllanthus urinaria L.; the universal mechanism for the regulation of nyctinastic leaf-movement Peer-reviewed

    Minoru Ueda, Miho Asano, Yoshiyuki Sawai, Shosuke Yamamura

    Tetrahedron 55 (18) 5781-5792 1999/04

    DOI: 10.1016/s0040-4020(99)00236-7  

    ISSN: 0040-4020

  179. Chemical studies on the nyctinastic leaf-movement regulated by a biological clock Peer-reviewed

    M Ueda, S Yamamura

    HETEROCYCLES 51 (4) 927-940 1999/04

    ISSN: 0385-5414

  180. Chemical substances controlling plant leaf movement Peer-reviewed

    M Ueda, S Yamamura

    REVIEWS ON HETEROATOM CHEMISTRY 19 237-260 1999

    ISSN: 0915-6151

  181. Leaf-opening substance of Mimosa pudica L.; Chemical studies on the other leaf movement of mimosa Peer-reviewed

    M Ueda, S Yamamura

    TETRAHEDRON LETTERS 40 (2) 353-356 1999/01

    DOI: 10.1016/S0040-4039(98)02349-1  

    ISSN: 0040-4039

  182. Chemical substances controlling the leaf-movement of the plants : How does biological clock control the plant movement? Peer-reviewed

    Minoru Ueda, Shosuke Yamamura

    Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 57 (7) 571-580 1999

    Publisher: Society of Synthetic Organic Chemistry

    DOI: 10.5059/yukigoseikyokaishi.57.571  

    ISSN: 0037-9980

  183. 植物を動かす化学物質を追って-オジギソウはなぜおじぎする?

    上田実

    化学 54 (3) 42-48 1999

    Publisher:

    ISSN: 0451-1964

  184. リガンド/レセプター間相互作用をフェムトモルレベルで分析する方法

    上田実

    化学 66-67 1999

  185. Phyllurine, leaf-opening substance of a nyctinastic plant, Phyllanthus urinaria L. Peer-reviewed

    M Ueda, M Asano, S Yamamura

    TETRAHEDRON LETTERS 39 (52) 9731-9734 1998/12

    DOI: 10.1016/S0040-4039(98)02237-0  

    ISSN: 0040-4039

  186. Leaf-opening substance in the nyctinastic plant, Albizzia julibrissin Durazz Peer-reviewed

    M Ueda, Y Sawai, Y Shibazaki, C Tashiro, T Ohnuki, S Yamamura

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62 (11) 2133-2137 1998/11

    DOI: 10.1271/bbb.62.2133  

    ISSN: 0916-8451

    eISSN: 1347-6947

  187. A new molecular mechanism of blue color development with protocyanin, a supramolecular pigment from cornflower, Centaurea cyanus Peer-reviewed

    Tadao Kondo, Minoru Ueda, Minoru Isobe, Toshio Goto

    Tetrahedron Letters 39 (45) 8307-8310 1998/11

    DOI: 10.1016/s0040-4039(98)01858-9  

    ISSN: 0040-4039

  188. Leaf-opening substance in the nyctinastic plant, Albizzia julibrissin Durazz Peer-reviewed

    M Ueda, Y Sawai, Y Shibazaki, C Tashiro, T Ohnuki, S Yamamura

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62 (11) 2133-2137 1998/11

    DOI: 10.1271/bbb.62.2133  

    ISSN: 0916-8451

    eISSN: 1347-6947

  189. Molecular mechanism of the control of nyctinastic leaf-movement in Lespedeza cuneata G. Don Peer-reviewed

    Takashi Ohnuki, Minoru Ueda, Shosuke Yamamura

    Tetrahedron 54 (40) 12173-12184 1998/10

    DOI: 10.1016/s0040-4020(98)00747-9  

    ISSN: 0040-4020

  190. Leaf-opening substance of a nyctinastic plant, Cassia mimosoides Peer-reviewed

    M Ueda, T Ohnuki, S Yamamura

    PHYTOCHEMISTRY 49 (3) 633-635 1998/10

    DOI: 10.1016/S0031-9422(98)00134-4  

    ISSN: 0031-9422

  191. Chemical studies on plant movement Peer-reviewed

    M Ueda, S Yamamura

    CURRENT ORGANIC CHEMISTRY 2 (4) 437-461 1998/07

    ISSN: 1385-2728

  192. The enzymatic transformation of leaf-movement factor in Lespedeza cuneata G. Don controlled by a biological clock Peer-reviewed

    M Ueda, T Ohnuki, S Yamamura

    CHEMISTRY LETTERS (2) 179-180 1998

    DOI: 10.1246/cl.1998.179  

    ISSN: 0366-7022

    eISSN: 1348-0715

  193. ”動く植物”の化学-植物はなぜ眠るのか- Peer-reviewed

    上田実

    化学と工業 51 (2) 191-194 1998

    Publisher:

    ISSN: 0022-7684

  194. cis-p-coumaroylagmatine, the genuine leaf-opening substance of a nyctinastic plant, Albizzia julibrissin Durazz Peer-reviewed

    M Ueda, C Tashiro, S Yamamura

    TETRAHEDRON LETTERS 38 (18) 3253-3256 1997/05

    DOI: 10.1016/S0040-4039(97)00578-9  

    ISSN: 0040-4039

  195. The chemical control of leaf-movement in a nyctinastic plant, Lespedeza cuneata G Don Peer-reviewed

    M Ueda, T Ohnuki, S Yamamura

    TETRAHEDRON LETTERS 38 (14) 2497-2500 1997/04

    DOI: 10.1016/S0040-4039(97)00376-6  

    ISSN: 0040-4039

  196. 植物はなぜ眠る Peer-reviewed

    上田実

    バイオサイエンスとインダストリー 37-38 1997

  197. Newly elucidated mechanism for blue flower color development Peer-reviewed

    T Kondo, M Ueda, K Yoshida

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 54 (1) 42-53 1996/01

    DOI: 10.5059/yukigoseikyokaishi.54.42  

    ISSN: 0037-9980

  198. Newly elucidated mechanism for blue flower color development Peer-reviewed

    T Kondo, M Ueda, K Yoshida

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 54 (1) 42-53 1996/01

    ISSN: 0037-9980

  199. 磁気円二色性スペクトル Peer-reviewed

    上田 実, 近藤忠雄

    有機合成化学協会誌 54 (1) 68-68 1996

    ISSN: 0037-9980

  200. PHYLLANTHURINOLACTONE, A LEAF-CLOSING FACTOR OF NYCTINASTIC PLANT, PHYLLANTHUS-URINARIA L Peer-reviewed

    M UEDA, T SHIGEMORISUZUKI, S YAMAMURA

    TETRAHEDRON LETTERS 36 (35) 6267-6270 1995/08

    DOI: 10.1016/0040-4039(95)01256-H  

    ISSN: 0040-4039

  201. TRIGONELLINE, A LEAF-CLOSING FACTOR OF THE NYCTINASTIC PLANT, AESCHYNOMENE INDICA Peer-reviewed

    M UEDA, M NIWA, S YAMAMURA

    PHYTOCHEMISTRY 39 (4) 817-819 1995/07

    DOI: 10.1016/0031-9422(95)00064-E  

    ISSN: 0031-9422

  202. Direct Observation of a Small-Molecule Associated Supramolecular Pigment, Commelinin, by Electrospray Ionization Mass Spectroscopy Peer-reviewed

    Tadao Kondo, Minoru Ueda, Kumi Yoshida, Koiti Titani, Minoru Isobe, Toshio Goto

    Journal of the American Chemical Society 116 (16) 7457-7458 1994/08

    DOI: 10.1021/ja00095a079  

    ISSN: 0002-7863

    eISSN: 1520-5126

  203. Composition of Protocyanin, A Self-Assembled Supramolecular Pigment from the Blue Cornflower,Centaurea cyanus Peer-reviewed

    Tadao Kondo, Minoru Ueda, Hirotoshi Tamura, Kumi Yoshida, Minoru Isobe, Toshio Goto

    Angewandte Chemie International Edition in English 33 (9) 978-979 1994/05/18

    DOI: 10.1002/anie.199409781  

    ISSN: 0570-0833

    eISSN: 1521-3773

  204. STRUCTURE OF CYANODELPHIN, A TETRA-PARA-HYDROXYBENZOATED ANTHOCYANIN FROM BLUE FLOWER OF DELPHINIUM-HYBRIDUM Peer-reviewed

    T KONDO, K SUZUKI, K YOSHIDA, K OKI, M UEDA, M ISOBE, T GOTO

    TETRAHEDRON LETTERS 32 (44) 6375-6378 1991/10

    DOI: 10.1016/0040-4039(91)80173-4  

    ISSN: 0040-4039

  205. STRUCTURE OF CYANODELPHIN, A TETRA-PARA-HYDROXYBENZOATED ANTHOCYANIN FROM BLUE FLOWER OF DELPHINIUM-HYBRIDUM Peer-reviewed

    T KONDO, K SUZUKI, K YOSHIDA, K OKI, M UEDA, M ISOBE, T GOTO

    TETRAHEDRON LETTERS 32 (44) 6375-6378 1991/10

    DOI: 10.1016/0040-4039(91)80173-4  

    ISSN: 0040-4039

  206. STRUCTURE OF TERNATIN-B1, A PENTAACYLATED ANTHOCYANIN SUBSTITUTED ON THE B-RING ASYMMETRICALLY WITH 2 LONG CHAINS Peer-reviewed

    T KONDO, M UEDA, T GOTO

    TETRAHEDRON 46 (13-14) 4749-4756 1990

    DOI: 10.1016/S0040-4020(01)85593-9  

    ISSN: 0040-4020

Show all ︎Show first 5

Misc. 64

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    Minoru Ueda

    Journal of Synthetic Organic Chemistry, Japan 83 (2) 99-99 2025/02/01

    Publisher: The Society of Synthetic Organic Chemistry, Japan

    DOI: 10.5059/yukigoseikyokaishi.83.99  

    ISSN: 0037-9980

    eISSN: 1883-6526

  3. 吉田久美先生に日本学士院賞 Invited

    上田 実

    有機合成化学協会誌 2025

  4. DISCOVERY 植物ホルモン受容体に見る分子糊の2つの作用機構 Invited

    上田 実, 松本幸太郎, 加治拓也

    MEDCHEM NEWS 35 28-33 2025

  5. 読売新聞・記事 ニュースの門 睡眠「新常識」

    読売新聞 朝刊 2024年12月14日 2024/12

  6. 天然物の立体異性体を用いた植物ホルモンシグナル伝達の化学制御

    林 謙吾, 上田 実

    ケミカルバイオロジー(日本ケミカルバイオロジー学会機関誌) 2024/10

  7. 長年の謎・植物の温度センサー分子を発見! Invited

    村岡勇樹, 上田 実

    月刊化学 79 (2) 2024/02

  8. Difference in the ligand affinity among plant hormone receptors of rice.

    奥村太知, 北島紬, 加治拓哉, 浦野晴行, 松本幸太郎, 稲垣秀生, 宮本皓司, 岡田憲典, 上田実

    植物の生長調節 58 (Supplement) 2023

    ISSN: 1346-5406

  9. ジャスモン酸と植物の香りのケミカルバイオロジー Invited

    奥村太知, 上田 実

    化学と教育 73 2023

  10. 最近のジャスモン酸シグナル研究 Peer-reviewed

    上田 実, 齊藤里菜, 林 謙吾

    植物の生長調節 56 26-34 2021/01

  11. Recent advances in plant chemical biology of jasmonates

    Minoru Ueda, Takuya Kaji, Wataru Kozaki

    International Journal of Molecular Sciences 21 (3) 2020/02/01

    DOI: 10.3390/ijms21031124  

    ISSN: 1661-6596

    eISSN: 1422-0067

  12. 有機化学者が計算化学者に助けてもらってリガンド-受容体間ドッキングシミュレー ションによる分子設計に成功するまで Peer-reviewed

    上田実, 高岡洋輔, 齋藤大明

    分子シミュレーション学会誌 "アンサンブル" 21 (3) 196-203 2019/07

    ISSN: 1884-6750

  13. 天然物立体異性体を用いる植物ホルモン活性の化学チューニング(ミニレビュー) Invited

    上田 実

    日本農薬学会誌 44 34-39 2019

  14. Development of rice jasmonate receptor subtype-selective synthetic ligands

    三井麻里有, 奥村太知, 北島紬, 加治拓哉, 林謙吾, 稲垣秀生, 宮本皓司, 岡田憲典, 上田実, 上田実

    日本化学会春季年会講演予稿集(Web) 104th 2024

  15. Screening of rice jasmonate receptor subtype-selective ligands from coronatine analogues.

    北島紬, 奥村太知, 加治拓哉, 三井麻里有, 林謙吾, 浦野晴行, 松本幸太郎, 稲垣秀生, 宮本皓司, 岡田憲典, 上田実

    植物の生長調節 58 (Supplement) 2023

    ISSN: 1346-5406

  16. イネのジャスモン酸受容体OsCOI2の下流シグナル伝達の解明

    稲垣秀生, 湯本絵美, 高岡洋輔, 岡田憲典, 上田実, 上田実, 宮本皓司

    日本植物学会大会研究発表記録(CD-ROM) 87th 2023

  17. Elucidation of the downstream signal of OsCOI2 that play a crucial role in rice JA response

    稲垣秀生, 池田百伽, 湯本絵美, 林謙吾, 高岡洋輔, 上田実, 宮本皓司, 宮本皓司

    植物の生長調節 57 (Supplement) 2022

    ISSN: 1346-5406

  18. 強心配糖体ウアバインの非糖部ウアバゲニンが示したウアバインに相反する生物活性

    田村理, 岡田麻衣子, 加藤茂明, 篠田康晴, 塩田倫史, 福永浩司, 渡辺彰吾, 山元修成, 程久美子, 上田実

    日本生薬学会年会講演要旨集 67th 2021

    ISSN: 0919-1992

  19. Development of receptor subtype selective ligands via focused library screening composed of stereoisomers of coronatine

    林謙吾, 加藤信樹, 野本春菜, 中山美涼, 加治拓哉, 渡部楽, 齊藤里菜, 高岡洋輔, 宮本皓司, 稲垣秀生, 岡田憲典, 上田実

    日本化学会春季年会講演予稿集(Web) 101st 2021

  20. Research on functional difference of jasmonate receptors in rice

    稲垣秀生, 湯本絵美, 朝比奈雅志, 内田健一, 朝比奈雅志, 内田健一, 林謙吾, 加治拓哉, 高岡洋輔, 上田実, 岡田憲典, 山根久和, 山根久和, 宮本皓司

    植物の生長調節 55 (Supplement) 2020

    ISSN: 1346-5406

  21. Development of receptor subtype selective ligands via focused library screening composed of stereoisomers of coronatine

    林謙吾, 加藤信樹, 渡部楽, 高岡洋輔, 野本春菜, 中山美涼, 宮川咲季, 宮本皓司, 稲垣秀生, 岡田憲典, 加治拓哉, 上田実

    天然有機化合物討論会講演要旨集(Web) 62nd 2020

    ISSN: 2433-1856

  22. 植物ホルモン・ジャスモン酸の多様な活性を制御するケミカルツールの合理的設計 植物の生長と防御を操作する化合物の創製

    高岡洋輔, 高岡洋輔, 上田実, 上田実

    化学と生物 58 (4) 2020

    ISSN: 0453-073X

  23. Screening of stereochemical library of coronatine for development of the target subtype selective ligand

    林謙吾, 加藤信樹, 渡部楽, 宮本皓司, 稲垣秀生, 岡田憲典, 齊藤里菜, 山神壮平, 野本春菜, 中山美涼, 加治拓哉, 上田実

    万有仙台シンポジウム 31st 2020

  24. ウアバゲニンが示したウアバインとは全く異なる生物活性

    田村理, 田村理, 岡田麻衣子, 加藤茂明, 篠田康晴, 塩田倫史, 福永浩司, 程(宇井)久美子, 河野富一, 上田実

    日本薬学会年会要旨集(CD-ROM) 139th 2019

  25. 強心配糖体ウアバインのアグリコン「ウアバゲニン」の新規生理活性. Invited Peer-reviewed

    田村 理, 岡田麻衣子, 上田 実

    化学と生物 56 184-189 2018/03

  26. Enantiodifferential approach for the target protein detection of the jasmonate glucoside that controls the leaf closure of samanea saman

    Yousuke Takaoka, Minoru Ueda

    Methods in Molecular Biology 1795 149-158 2018

    Publisher: Humana Press Inc.

    DOI: 10.1007/978-1-4939-7874-8_13  

    ISSN: 1064-3745

  27. The alkyne-tag Raman imaging of coronatine, a plant pathogen virulence factor, in: Commelina communis and its possible mode of action

    Minoru Ueda, Kengo Hayashi, Syusuke Egoshi, Yasuhiro Ishimaru, Yousuke Takaoka, Hiroyuki Yamakoshi, Kosuke Dodo, Mikiko Sodeoka

    Organic and Biomolecular Chemistry 16 (18) 3348-3352 2018

    Publisher: Royal Society of Chemistry

    DOI: 10.1039/c8ob00097b  

    ISSN: 1477-0520

  28. Protein ligand-tethered synthetic calcium indicator for localization control and spatiotemporal calcium imaging in plant cells (vol 26, pg 9, 2016)

    Yousuke Takaoka, Miyuki Shigenaga, Masaki Imai, Yuuki Nukadzuka, Yasuhiro Ishimaru, Kei Saito, Ryusuke Yokoyama, Kazuhiko Nishitani, Minoru Ueda

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26 (12) 2974-2974 2016/06

    DOI: 10.1016/j.bmcl.2016.04.050  

    ISSN: 0960-894X

    eISSN: 1464-3405

  29. ジャスモン酸共受容体サブタイブ選択的アゴニストの合理的設計とin vivo機能評価

    高岡洋輔, 岩橋万奈, 斎藤大明, 江越脩祐, 加藤信樹, 石丸泰寛, 上田実

    植物の生長調節 51 (Supplement) 2016

    ISSN: 1346-5406

  30. 植物ホルモン受容体を標的としたサブタイプ選択的PPI誘起リガンドの開発

    岩橋万奈, 江越脩祐, 齋藤大明, 石丸泰寛, 高岡洋輔, 上田実

    天然有機化合物討論会講演要旨集(Web) 58th 2016

    ISSN: 2433-1856

  31. S09 Development of subtype selective agonist of Jasmonate Co-receptor

    Takaoka Yousuke, Iwashita Toshiki, Iwahashi Mana, Hayashi Kengo, Suzuki Takeshi, Ishimaru Yasuhiro, Egoshi Shusuke, Ueda Minoru

    50 31-31 2015/10/01

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

  32. P075 GTR1 is involved in attenuation of excess JA responses by the JA-Ile translocation from wounded to undamaged leaves

    Oikawa Takaya, Ishimaru Yasuhiro, Suzuki Takeshi, Takeishi Syohei, Matsuura Hideyuki, Takahashi Kousaku, Hamamoto Shin, Uozumi Nobuyuki, Shimizu Takafumi, Seo Mitsunori, Ohta Hiroyuki, Ueda Minoru

    50 93-93 2015/10/01

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

  33. P076 Jasmonic acid negatively regulates lateral root formation through the site-specific stabilization of Aux/IAAs in Arabidopsis thaliana

    Suzuki Takeshi, Ishimaru Yasuhiro, Meesters Christian, Kombrink Erich, Chinen Takumi, Usui Takeo, Takahashi Kosaku, Matsuura Hideyuki, Hayashi Ken-ichiro, Fukaki Hidehiro, Ueda Minoru

    50 94-94 2015/10/01

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

  34. 4-2-1 イネ鉄欠乏応答におけるユビキチンリガーゼHRZとジャスモン酸経路の関与(4-2 植物の微量栄養素,2015年度京都大会)

    小林 高範, 板井 玲子, 瀬野浦 武志, 及川 貴也, 石丸 泰寛, 上田 実, 中西 啓仁, 西澤 直子

    日本土壌肥料学会講演要旨集 (61) 65-65 2015/09/09

    Publisher: 一般社団法人日本土壌肥料学会

    ISSN: 0288-5840

  35. 植物毒素コロナチンの誘導体化による植物ホルモン受容体サブタイプ選択的アゴニスト開発と未知標的探索

    高岡洋輔, 岩下利基, 岩橋万奈, 鈴木健史, 林謙吾, 石丸泰寛, 江越脩祐, 上田実

    天然有機化合物討論会講演要旨集(Web) 57th 2015

    ISSN: 2433-1856

  36. CYP94ファミリー遺伝子の発現上昇はイネの塩処理条件下での生存能を高める

    黒谷賢一, 林憲志, 畑中彩希, 戸田陽介, 小川大輔, 市川裕章, 石丸泰寛, 田下諒, 鈴木健史, 上田実, 服部束穂, 武田真

    日本植物生理学会年会要旨集 56th 2015

  37. Fabrication of podophyllotoxin nanoparticles as pure nanodrugs and their anti-cancer properties

    Hitoshi Kasai, Yoshikazu Ikuta, Yoshitaka Koseki, Tsunenobu Onodera, Tatsuya Murakami, Minoru Ueda, Hidetoshi Oikawa

    21st International Congress of Chemical and Process Engineering, CHISA 2014 and 17th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, PRES 2014 2 1132-1133 2014/01/01

  38. 84. Comprehensive analysis of Samanea K^+ channels involved in nyctinasty

    Oikawa Takaya, Ishimaru Yasuhiro, Hamamoto Shin, Uozumi Nobuyuki, Ueda Minoru

    48 99-99 2013/10/04

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

  39. 41. Synthesis of alkyne-containing coronatines : towards application to in vivo Raman imaging

    Egoshi Syusuke, Tashita Ryo, Yamakoshi Hiroyuki, Dodo Kosuke, Ishimaru Yasuhiro, Genji Takahisa, Sodeoka Mikiko, Ueda Minoru

    48 56-56 2013/10/04

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

  40. Chemical Studies on the Nyctinastic and Trap-closing movements of plants

    Ueda Minoru

    48 13-13 2013/10/04

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

  41. 56. Jasmonate Glucoside: COI1-JAZs independent induction of leaf-closing movement in Samanea saman

    Ueda Minoru, Nakamura Yoko, Hamamoto Shin, Uozumi Nobuyuki, Boland Wilhelm, Mithofer Axel, Kombrink Erich

    (45) 73-73 2010/10/01

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

    More details Close

    We recently identified jasmonate glucoside (Leaf-closing Factor: LCF), a β-D-glucopyranoside of 12-OH JA, as a bioactive metabolite controlling nyctinastic leaf movement of Samanea saman, which has been used as a model plant in the studies on nyctinastic leaf movement of legumes. The bioactivity of LCF is completely different from other jasmonate derivatives. Here, we demonstrate that JA activity mediated through the COI1-JAZs signalling module and leaf-closing activity (with cell-shrinking acitivity) of JA glucoside might belong to independent signalling pathways. However, COI1-JAZ-dependent and independent signaling pathways may exists in the same plant side by side, as our results demonstrate because S. saman is responding to both LCF and JA in different mechanisms based on independent signalling modules. Our result implies the existence of an additional mode of action on jasmonates.

  42. 57. Efficient labeling of the target protein for the jasmonate glucoside by using biaryl-linked high performance molecular probe

    Inomata Sho, Nakamura Yoko, Ebine Makoto, Iwakura Izumi, Ueda Minoru

    (45) 74-74 2010/10/01

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

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    Most leguminous plants close their leaves in the evening, and open them in the morning. Jasmonate glucoside 1 was isolated as the leaf-closing factor (LCF) of Samanea (Albizia) plants. We detected the candidate for the target protein of 1, MTJG, by using molecular probe 2. Recently, our group designed and synthesized the biaryl-linked (BArL) probe 3, which showed high performance on the labeling of MTJG compared with the Gly_3-linked probe 2. Conformational analysis of BArL probe 3a indicated that this high performance came from the rigidness of its molecular shape due to the insertion of biaryl linker system which enabled the spatial aperture of molecular tag (biotin) from the jasmonate moiety.

  43. 10th Aroma Science Forum 2009: Jasmonate derivative as a chemical inducer of plant nyctinasty

    Aroma research 11 (3) 265-269 2010

    Publisher: フレグランスジャーナル社

    ISSN: 1345-4722

  44. Chemical Biology of Glycoside-Type Bioactive Substances Controlling Nyctinastic Movement in Leguminous Plants

    Yoshiyuki Manabe, Sho Inomata, Minoru Ueda

    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 22 (123-24) 16-25 2010/01

    DOI: 10.4052/tigg.22.16  

    ISSN: 0915-7352

  45. 39. Purification of the Target Protein for Potassium Isolespedezate Using Click Tagging Technology

    Manabe Yoshiyuki, Mukai Makoto, Ueda Minoru

    (44) 53-53 2009/10/06

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

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    Most leguminous plants close their leaves in the evening, as if to sleep, and open them in the morning according to the circadian rhythm. Potassium isolespedezate 1 is a leaf-opening factor of leguminous plant, Cassia obtusifolia. We planed to purify the target protein of 1, by labeling with FLAG peptide-tag. First, we labeled the target protein with azide group by incubating the iodoacetamide-type probe (2) with the motor cell protoplasts, which is the target cell of 1, and then, succeeded in introduction of FLAG using click chemistry. Then, the 83kDa cytoplasmic protein (CTPL; cytosolic target protein of lespedezate 1) was detected and purified as a target protein of 1. The analysis of CTPL by using LC-MS/MS revealed that CTPL shares homology with MetE (5-methyl-tetrahydropteroyltrigultamate-homocysteine methyltransferase).

  46. 40. Efficient Labeling of the Target Protein for the Leaf-Closing Factor of Albizzia Plants by Using Click Chemistry Type Molecular Probes

    Inomata Sho, Nakamura Yoko, Ebine Makoto, Ueda Minoru

    (44) 54-54 2009/10/06

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

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    Most leguminous plants close their leaves in the evening, and open them in the morning. Glycosylated jasmonate 1 was isolated as leaf-closing factor (LCF) of Albizzia plants. We detected the target membrane protein of 1 by using molecular probe 2. Here, we designed and synthesized more powerful molecular probe 3. Using click chemistry, we could introduce a variety of tags such as biotin and FLAG etc. into a molecular probe. In this way, we can examine the best combination of reactive functional group and tag.

  47. 89. Mode of action and cell response of jasmonate glucosides

    Nakamura Yoko, Hamamoto Shin, Inomata Sho, Mithofer Axel, Boland Wilhelm, Uozumi Nobuyuki, Ueda Minoru

    (44) 103-103 2009/10/06

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

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    Samanea plants close their leaves in the evening, as if to sleep, and open them in the morning according to the circadian rhythm. Potassium β-D-glucopyranosyl-12-hydroxyjasmonate (1) was isolated as leaf-closing factor (LCF) of S. saman. We developed molecular probes consisting of modified LCF1 in order to identify its mode of action. We have already demonstrated that a specific binding protein is involved in the motor cell of S. saman. We synthesized natural-type photoaffinity probe and biologically inactive enantiomer-type probe. We utilized them for photoaffinity labeling of the target protein for LCF1. By using protoplasts of motor cell, we found membrane protein of 38kDa which strictly recognizes the stereochemistry of 1, and it is highly likely that the protein is the target protein for LCF 1. Recently, we observed that LCF shrank motor cell protoplasts prepared from S. saman. And comparing the results of several bioassay using glucosyl jasmonate-type LCF and jasmonic acid, it is also interesting that the mode of action of LCF is completely different with that of jasmonate.

  48. 66. Synthesis and stomatal opening activity of coronatine

    Okada Masahiro, Ito Satoko, Matsubara Akira, Ueda Minoru

    (43) 80-80 2008/10/06

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 0919-1887

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    The phytotoxin coronatine 1 showed not only jasomonic acid mimetic biological activity, but also stomatal opening activity. In order to elucidate the chemical characteristics of stomatal opening, we synthesized 1 and their derivatives, and studied structure-activity relationships. Employing the Diels-Alder reaction of hydroxypyrone derivative 2 with cyclopentendione 3 as a key reaction in the formation of multifunctionalized intermediate 4, coronafacic acid 5 was synthesized in 6 steps. After condensation of 5 and coronamic acid benzyl ester 6, the resulting mixture was purified by HPLC to give 1. We investigated stomatal opening activities of 5 and 1, as well as jasmonic acid and isoleucine jasmonate. Coronatine 1 and isoleicine jasmonate showed stomatal opening activities, while 5 and jasmonic acid had no activity. The result indicated that coronatine 1 played the role for a molecular mimic of isoleucine jasmonate rather than jasmonic acid. Additionally, enantiomer of 1 did not showed stomatal opening activity. This result suggested that our enantiodifferential approach would be applicable for studies on the target protein of 1 using synthetic coronatine probe and enantiomer of 1.

  49. Enantio-Differential approach to the Receptor Protein of glycosylated Jasmonate-type Leaf-closing factor

    NAKAMURA Yoko, MIYATAKE Ryoji, INOMATA Sho, UEDA Minoru

    42 49-49 2007/10/05

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 1346-5406

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    Albizzia plants close their leaves in the evening, as if to sleep, and open them in the moerning according to the circadian rhythum. Compound 1 was isolated as leaf-closing factor 1 (LCF) of Albizzia plants. We developed molecular probes consisting of modified LCF in order to identify its mode of action. We synthesized enantio pair-type photoaffmity-labeling probes 2 and 3, and used them for photoaffinity labeling of receptor for LCF. By using protoplasts of motor cell, we found 35 kDa membrane protein strictly recognizes the stereochemistry of LCF, and it is highly likely that the protein is the specific receptor for LCF.

  50. Structure Determination of Leaf-opening Factor Regulating Nyctinasty from Lotus japonicus

    OKADA Masahiro, PARK Sungwook, UEDA Minoru

    42 48-48 2007/10/05

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 1346-5406

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    Most leguminous plants close their leaves in the evening, as if to sleep, and open them in the morning, called nyctinasty. The circadian rhythmic movements of their leaves are controlled by a pair of leaf-closing and -opening factors to vary the ratio between the two compounds. Five pairs of leaf-movement factors were identified from five legumes, respectively, and recent study revealed that each leaf-movement factor interacts its specific receptor. But, it seemed to be difficult to elucidate the detail of the signal transduction of nyctinasty, since these legumes have less genetic information. Here we reported to identify a novel leaf-opening factor from Lotus japonicus, possessing major advantages as a model legume for the study of genetic information. We screened the leaf-opening factor from extract of L. japonicus by a bioassay system using a leaf of L. japonicus. After solvent partition, the bioactive aqueous layer was purified by four steps of column chromatography and HPLC to give a pure active compound (136μg), which kept opening the leaf at 1 mg/L. The structure of the compound was identified as eucomic acid based on 800 MHz NMR with cold prove and MS/MS analyses. We synthesized eucomic acid, and its NMR spectrum and retention time of LC/MS analyses were identical to those of natural one. Furthermore, synthetic eucomic acid showed a significant biological activity at 10μM. We have thus confirmed that the leaf-opening factor of L. japonicus is eucomic acid.

  51. 就眠運動のリズムを調節する鍵酵素の精製とその性質

    加藤英介, 佐々木健彦, 上田実

    日本化学会講演予稿集 87th (2) 1244 2007/03/12

    ISSN: 0285-7626

  52. Bioactive substances to control nyctinasty of Albizzia plant and its biochemistry

    NAKAMURA Yoko, MATSUBARA Akira, MIYATAKE Ryoji, OKADA Masahiro, UEDA Minoru

    41 44-44 2006/10/04

    Publisher: The Japanese Society for Chemical Regulation of Plants

    ISSN: 1346-5406

  53. Affinity Purification of the Key Enzyme .BETA.-Glucosidase Controlling Nyctinastic Rhythm Movement

    KATO EISUKE, KUMAGAI TADAHIRO, UEDA MINORU

    日本化学会講演予稿集 86th (2) 1318 2006/03/13

    ISSN: 0285-7626

  54. Synthesis of Glyconoamidines as a Potent Inhibitor of .BETA.-Glucosidase Using Non-protected Thionolactum.

    KUMAGAI TADAHIRO, KATO EISUKE, UEDA MINORU

    日本化学会講演予稿集 86th (2) 1319 2006/03/13

    ISSN: 0285-7626

  55. 植物就眠運動の鍵酵素精製を目指したグルコノアミジン型アフィニティーゲルの開発

    加藤英介, 熊谷忠浩, 上田実

    化学系学協会東北大会プログラムおよび講演予稿集 2005 186 2005/09/15

  56. 44 Affinity Purification of the Key Enzyme β-Glucosidase Controlling Nyctinastic Movement of Leguminous Plant by Gluconoamidine Type Inhibitor

    Kato Eisuke, Kumagai Tadahiro, Ueda Minoru

    Symposium on the Chemistry of Natural Products, symposium papers 0 (47) 229-234 2005/09/15

    Publisher: Symposium on the chemistry of natural products

    DOI: 10.24496/tennenyuki.47.0_229  

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    Nyctinastic movement of leguminous plants is controlled by the glucosylated leaf-movement factor, whose concentration changes throughout the day, regulated by β-glucosidase. Therefore, in order to understand the controlling mechanism of the movement by circadian clock, purification of this key enzymeis essential. Many isozymes of β-glucosidase are known to exist in plant body. To purify the key enzyme from this mixture, affinity chromatography is a powerful tool. We have tried two affinity gel 4 and 5, which is an usual tool used for purification of β-glucosidase. But they were both not eff...

  57. グルコノアミジン類の効率的合成と就眠運動の鍵酵素β‐グルコシダーゼの精製

    加藤英介, 熊谷忠浩, 上田実

    万有生命科学振興国際交流財団仙台シンポジウム 16th 48 2005/05/28

  58. Purification study of the key enzyme .BETA.-glucosidase controlling nyctinasty using amidine type leaf-opening substance analog

    KATO EISUKE, KUMAGAI TADAHIRO, UEDA MINORU

    日本化学会講演予稿集 85th (2) 881 2005/03/11

    ISSN: 0285-7626

  59. Purification of .BETA.-glucosidase, the key enzyme of nyctinasty, which controls the nyctinastic movement of leguminous plants

    KATO EISUKE, YAMAMURA SHOSUKE, UEDA MINORU

    日本化学会講演予稿集 84th (2) 1028 2004/03/11

    ISSN: 0285-7626

  60. Development of Inhibitor of Nyctinasty Based on the Leaf-Opening Substance and Its Application for a Highly Selective Agrochemical

    KATO EISUKE, SUGIMOTO TAKANORI, YAMAMURA SHOSUKE, UEDA MINORU

    日本化学会講演予稿集 83rd (2) 918 2003/03/03

    ISSN: 0285-7626

  61. The bioorganic Chemical study about nyctinastic leafmovement of Albizzia julibrissin Durazz with fluorescence probe compounds

    NAGANO HIDEHARU, KATO EISUKE, YAMAMURA SHOSUKE, UEDA MINORU

    日本化学会講演予稿集 83rd (2) 918 2003/03/03

    ISSN: 0285-7626

  62. The Leaf-opening Substance of Sesbania speciosa Taub. and Application for a Highly Selective Agrochemical

    KATO EISUKE, TAKADA AKIRA, UEEDA KATSUHIRO, YAMAMURA SHOSUKE, UEDA MINORU

    日本化学会講演予稿集 82nd 200 2002/09/10

    ISSN: 0285-7626

  63. 68(P-47) Why does the leguminous plant sleep? : Chemical approach using synthetic inhibitor of nyctinasty

    Kato Eisuke, Sugimoto Takanori, Sawai Yoshiyuki, Ueda Katsuhiro, Takada Noboru, Yamamura Shosuke, Ueda Minoru

    Symposium on the Chemistry of Natural Products, symposium papers 0 (44) 397-402 2002/09/01

    Publisher: Symposium on the chemistry of natural products

    DOI: 10.24496/tennenyuki.44.0_397  

    More details Close

    Most legumes close their leaves in the evening, and open them at the morning. This movement is called nyctinasty. &quot;Why does the leguminous plant sleep?&quot; is the unsolvable question about the nyctinasty. Darwin and Bunning had a view to this problem, for example Darwin said that it is a movement to guard against the coldness of the night, and Bunning said it is to prevent reset of the biological clock by moonlight. But it couldn&#039;t be a theory cause they didn&#039;t have much supporting data. On base of the mechanism of nyctinastic movement, we have synthesized an inhibitor (2) of nyctinastic movem...

  64. Chemical Study on the Leaf-opening Substance of Sesbania speciosa Taub.

    KATO EISUKE, TAKADA NOBORU, UEDA KATSUHIRO, YAMAMURA SHOSUKE, UEDA MINORU

    日本化学会講演予稿集 81st (2) 737 2002/03/11

    ISSN: 0285-7626

Show all ︎Show first 5

Books and Other Publications 22

  1. バイオスティミュラントハンドブック : 植物の生理活性プロセスから資材開発、適用事例まで

    日本バイオスティミュラント協議会, 山内, 靖雄, 須藤, 修, 和田, 哲夫

    エヌ・ティー・エス 2022/04

    ISBN: 9784860437695

  2. すぐにできる! 双方向オンライン授業 【試験・評価編】 ―インターネットを活用した学習評価

    福村, 裕史, 河村, 一樹, 後藤, 顕一

    化学同人 2020/12/23

    ISBN: 4759820604

  3. Plant chemical genomics : methods and protocols

    Hicks, Glenn R., Zhang, Chunhua

    Humana Press 2020/12/04

    ISBN: 107160953X

  4. 生体分子反応を制御する: 化学的手法による機構と反応場の解明 (CSJカレントレビュー)

    日本化学会

    化学同人 2020/04/20

    ISBN: 4759813969

  5. マクマリー 生物有機化学 第8版(生化学編)

    上田 実

    丸善 2018

  6. 生体分子化学―基礎から応用まで

    上田 実

    講談社 2017

  7. 天然物の化学−魅力と展望」

    上田 実

    東京化学同人 2016

  8. CSJカレントレビュー19 生物活性分子のケミカルバイオロジー:標的同定と作用機構

    上田 実

    化学同人 2015

  9. マクマリー 生物有機化学 第4版(生化学編)

    上田 実

    丸善 2014

  10. Plant Electrophysiology Signaling and Responses

    UEDA Minoru

    Springer-Verlag 2012

  11. Recent Advances in Polyphenol Research, Volume 2

    UEDA Minoru

    Blackwell Publisher 2010

  12. Plant-Environment Interactions

    UEDA Minoru

    Springer-Verlag 2009

  13. マクマリー・生物有機化学 第2版(有機化学編)

    菅原二三男監訳, 今西 武, 上田 実, 大澤貫寿, 奥 忠武, 多田全宏, 田沼靖一, 浪越通夫, 平田敏文, 藤井政幸訳

    丸善 2007/03/01

  14. マクマリー・生物有機化学 第2版(生物化学編)

    菅原二三男監訳, 今西 武, 上田 実, 大澤貫寿, 奥 忠武, 多田全宏, 田沼靖一, 浪越通夫, 平田敏文, 藤井政幸訳

    丸善 2007/03/01

  15. 食虫植物に学ぶ記憶型センサー、「ファイバー スーパーバイオミメティックス--近未来創造テクノロジー--」

    上田 実

    NTS出版 2006/12/01

  16. 天然物化学—植物編

    上田 実

    アイ・シー・ピー 2006/11/01

  17. 植物の知恵−化学と生物からのアプローチ−

    上田実

    大学教育出版 2005/10/01

  18. 不思議な生物現象の化学 生物現象鍵物質

    上田 実

    クバプロ 2005/10/01

  19. 動く植物−その謎解き−

    上田 実, 高田 晃, 山村庄亮

    大学教育出版 2002/05/01

  20. マクマリー・生物有機化学(有機化学編)

    菅原二三男監訳, 今西 武, 上田 実, 大澤貫寿, 奥 忠武, 多田全宏, 田沼靖一, 浪越通夫, 平田敏文, 藤井政幸訳

    丸善 2002/03/01

  21. マクマリー・生物有機化学(生物化学編)

    菅原二三男監訳, 今西 武, 上田 実, 大澤貫寿, 奥 忠武, 多田全宏, 田沼靖一, 浪越通夫, 平田敏文, 藤井政幸訳

    丸善 2002/03/01

  22. Plant Chemical Genomics (Methods in Molecular Biology Vol.1795)

    UEDA Minoru

    Springer Nature

Show all Show first 5

Presentations 146

  1. To be announced Invited

    Minoru Ueda

    Chemical Mediators in Complex Biosystems" (ChemBioSys), Jena, Germany

  2. ジャスモン酸のシグナル伝達 Invited

    上田 実

    植物化学調節学会60周年記念シンポジウム「植物化学調節研究60年〜レジェンド研究者と現役研究者が照す化合物探究の軌跡と未来への展望」 2025/11/01

  3. Molecular evolution of oxylipin plant hormones: “ancestral” plant hormones in Marchantia polymorpha Invited

    Minoru Ueda

    32th IUPAC International Symposium on the Chemistry of Natural Products & 12th IUPAC International Congress on the Biodiversity (IUPAC ISCNP32-ICOB12) 2025/08/24

  4. Exploring the Origin and Evolution of Bioactive Natural Products in Plants: A Case Study of Plant Oxylipin Hormones Invited

    Minoru Ueda

    Interactive seminar #26 2025/08/02

  5. Downstream metabolites of cis-OPDA have jasmonate bioactivity Invited

    Minoru Ueda

    International Plant Growth Substance Association 2025 (IPGSA2025) Conference 2025/07

  6. イネのオキシリピン植物ホルモン受容体に対するサブタイプ選択的分子糊の開発 Invited

    上田 実

    学術変革領域「潜在空間分子設計」第3回公開シンポジウム 2025/05/29

  7. ファイトケミカルバイオロジー:化学と生物学をつなぐ天然物 Invited

    中西香爾先生御生誕百年記念会 2025/05/17

  8. Synthetic Small Molecules for the Targeted Modulation of Jasmonate Signaling in Plants Invited

    Minoru Ueda

    Natural Product Symposium@PKU, Beijin, China 2025/05/15

  9. 植物シグナル伝達の自在制御を目指したサブタイプ選択的分子糊の開発 Invited

    上田 実

    日本薬学会第145年会(福岡) 2025/03/27

  10. 植物ホルモンの化学進化と生合成経路シフト Invited

    日本農芸化学会 2025年度大会シンポジウム「ファイトケミカル天然物化学」 2025/03/06

  11. An ancestral plant hormone Δ4-dn-iso-OPDA in Marchantia polymorpha Invited

    Minoru Ueda

    5th European Conference on Natural Products Chemistry (ECNP2024) 2024/10/24

  12. 植物ホルモン類縁体ライブラリーを用いる天然物ケミカルバイオロジー Invited

    上田 実

    日本農芸化学会2024年大会シンポジウム「天然物ケミカルバイオロジーと深層学習の融合による新規生物活性分子の探索と創出」 2024/03/27

  13. 現象と分子の天然物化学から植物ケミカルバイオロジーへ Invited

    上田 実

    さきがけ「植物分子の機能と制御」領域会議 2023/12/04

  14. Development of Natural-Product-based molecular glue for a specific subtype of plant hormone co-receptor Invited

    Minoru Ueda

    the IUPAC ISCNP31 – ICOB11 2023/10/15

  15. Development of Synthetic Ligands for COI1-JAZ Co-receptor System Invited

    Minoru Ueda

    The 2023 Jasmonate Meeting 2023/08/30

  16. Development of small molecular agonist of subtype selectivity for jasmonate co-receptor COI1-JAZ Invited

    Minoru Ueda

    The 24th International Conference on Plant Growth Substances (IPGSA2023) 2023/07/05

  17. 植物宿主特異的毒素における化学コミュニケーションの理解と制御 Invited

    上田 実

    新学術領域研究「化学コミュニケーションのフロンティア」取りまとめシンポジウム 2022/07/09

  18. 天然有機化合物と生物科学:上村先生の思い出 Invited

    上田 実

    上村大輔教授追悼記念講演会 2022/04/29

  19. Chemical tuning of plant hormone target: a natural product-based approach Invited

    Minoru Ueda

    2021/12/18

  20. Chemical approach to dissect the plant hormone signaling Invited

    2021/12/16

  21. 天然物立体異性体を用いる植物ホルモン受容体標的選択性の化学チューニング Invited

    上田 実

    日本農芸化学会2020年度大会 2021/03/19

  22. ファイトケミカル天然物化学 Invited

    上田 実

    日本化学会第101春期年会(オンライン 2021/03/19

  23. ファイトケミカル天然物化学:ユニークな構造と生物学への展開 Invited

    上田 実

    日本化学会第100春期年会 2020/03/25

  24. 生物時計と植物の就眠運動をつなぐイオンチャネルの時間制御 Invited

    上田 実

    第26回日本時間生物学会大会 2019/10/12

  25. 微生物ー植物間コミュニケーションの天然物ケミカルバイオロジー Invited

    上田 実

    微生物ウィーク2019 2019/07/26

  26. 生物活性に着目した天然物研究:天然物ケミカルバイオロジーとは何か Invited

    上田 実

    第54回天然物化学談話会 2019/07/03

  27. 天然物をベースとした植物ケミカルバイオロジー Invited

    上田 実

    日本ケミカルバイオロジー学会第14回年会 2019/06/11

  28. 天然物を用いる植物ホルモンジャスモン酸類シグナル伝達機構の制御 Invited

    上田 実

    新学術領域「生合成リデザイン」第6回公開シンポジウム 2019/05/25

  29. A rationally designed JAZ-subtype selective agonist of COI1-JAZ co-receptor Invited

    Minoru Ueda

    2019/04/02

  30. 植物の天然物ケミカルバイオロジー:目標と未来 Invited

    上田 実

    理研セミナー・ケミカルバイオロジーチュートリアル 2019/01

  31. 天然物立体異性体を用いる植物ホルモンの標的選択性制御 Invited

    上田 実

    京都大学学際融合教育研究推進センター 生理化学研究ユニット第8回公開シンポジウム 2018/12

  32. Chemical tuning of plant hormone by using stereoisomer of a natural product Invited

    2018/11/27

  33. 天然物立体異性体を用いる植物病原菌耐性の化学チューニング Invited

    上田 実

    新学術領域「化学コミュニケーションのフロンティア」第3回公開シンポジウム 2018/06

  34. 天然物立体異性体を用いる植物ホルモン活性の化学チューニング Invited

    上田 実

    日本農薬学会第43回大会 シンポジウム「先端技術と農薬の未来像」 2018/05

  35. 天然物の科学:ケミカルバイオロジーとChemistry&Biology Invited

    上田 実

    日本農芸化学会年会シンポジウム「これからの天然物サイエンス」 2018/03

  36. Plant Chemical Biology with Bioactive Natural Products International-presentation Invited

    UEDA Minoru

    the International Symposium on Systems, Synthetic and Chemical Biology 2017/12

  37. 生理活性天然有機化合物と植物科学 Invited

    上田 実

    山田科学振興財団40周年記念シンポジウム 2017/10

  38. 植物の天然物ケミカルバイオロジー Invited

    上田 実

    第21回天然薬物の開発と応用シンポジウム 2016/10

  39. 植物生理活性物質のケミカルバイオロジー Invited

    上田 実

    第89回日本生化学会大会(仙台)シンポジウム「生物活性と創薬のケミカルバイオロジー」 2016/09

  40. 植物の天然物ケミカルバイオロジー Invited

    上田 実

    新学術領域 天然物ケミカルバイオロジー 成果取りまとめシンポジウム 2016/07

  41. Plant Chemical Biology using Bioactive Natural Products International-presentation Invited

    UEDA Minoru

    RIKEN-Max Planck Joint Research Center Fifth Annual Symposium 2016/04

  42. Chemical biology of coronatine: Pathogenic infection in plants International-presentation Invited

    UEDA Minoru

    Pacifichem 2015 symposium#66 Natural product-based drug discovery 2015/12

  43. 生物の謎に挑むケミカルバイオロジー Invited

    上田 実

    第5回CSJ化学フェスタ 2015/10

  44. 天然物と相互作用するタンパク質のケミカルバイオロジー Invited

    上田 実

    バイオ高分子研究会 2015/09

  45. ジャスモン酸類のケミカルバイオロジー Invited

    上田 実

    日本農芸化学会2015年度大会シンポジウム「生命恒常性の維持に寄与するケミカルリガンド受容機構の新展開」 2015/03

  46. Chemical Biology of Coronatine: the effect on the guard cell Invited

    上田 実

    第56回日本植物生理学会年会 シンポジウム 2015/03

  47. 植物の生物現象を制御するジャスモン酸誘導体の新たな機能 Invited

    上田 実

    第51回植物化学シンポジウム 2014/11

  48. 植物天然毒素コロナチンの気孔開口作用解明を目指した植物細胞のin vivoラマンイメージング Invited

    上田 実

    最先端光計測とライフサイエンスの近未来-バイオ・ラマン2017- 2014/05

  49. Chemistry and Biology of Nyctinastic Plant Movement International-presentation Invited

    UEDA Minoru

    Nakanishi Symposium 2014/03

  50. CHEMICAL BIOLOGY OF PLANT AND ANIMAL HORMONES: “GLYCOSYLATION SWITCHING” International-presentation Invited

    UEDA Minoru

    25th Mona Symposium 2014/01

  51. 天然物化学から天然物ケミカルバイオロジーへ Invited

    上田 実

    第48回FIBERレクチャー 2014/01

  52. “Glycosylation Switching": In vivo glycosylation of bioactive natural products regulates their mode-of-action International-presentation Invited

    UEDA Minoru

    ICCEOCA8/NICCEOCA4 2013/11

  53. “Chemical Biology of Glycoside Natural Products” International-presentation Invited

    UEDA Minoru

    RACI NSW Natural Products Symposium 2013 2013/10

  54. 天然物ケミカルバイオロジー Invited

    上田 実

    第3回CSJ化学フェスタ「技術革新の種を撒く:新学術領域が目指す未来の化学技術」 2013/10

  55. 植物の就眠ならびに捕虫運動の制御機構の化学的解明 Invited

    上田 実

    第48回植物化学調節学会大会 2013/10

  56. ヒト内因性配糖体ホルモン ouabain のケミカルバイオロジー研究 Invited

    上田 実

    第1回東北大学メディカルサイエンスシンポジウム 2013/08

  57. "Glycosylation Switching":生物に学ぶ新しい化学的活性制御 Invited

    上田 実

    万有仙台シンポジウム 2013/06

  58. "Glycosylation Switching"による天然物リガンドの活性制御 Invited

    上田 実

    日本化学会春期年会特別企画、ケミカルバイオロジーの新展開-有機化学から発信するライフサイエンス新戦略I 2013/03

  59. 配糖体型天然物リガンドの化学生物学 Invited

    上田 実

    第23回神奈川大学平塚シンポジウム 2013/03

  60. “Glycosylation Switching”: Glycosylation regulates mode-of-action of bioactive natural products International-presentation Invited

    UEDA Minoru

    3rd International Symposium on Creation of Functional Materials-Life Science and Materials- 2012/12

  61. 配糖体型天然物リガンドのケミカルバイオロジーに見る活性制御の新戦略 Invited

    上田 実

    後期(秋期)有機合成化学講習会 2012/11

  62. 「植物の運動」の化学生物学 Invited

    上田 実

    第12回学習院大学生命科学シンポジウム 2012/11

  63. Chemical Biology of Naturally Occurring Glycosides: "Glycosylation Switching" International-presentation Invited

    UEDA Minoru

    The International Symposium on Chemical Biology of Natural Products 2012/10

  64. 配糖体型天然物リガンドのケミカルバイオロジーに見る活性制御の新戦略 Invited

    上田 実

    2012年生命医薬情報学連合大会 2012/10

  65. 天然物ケミカルバイオロジー:配糖体リガンドの新しい機能 Invited

    上田 実

    早稲田大学FBT生物学・化学・情報科学融合のための戦略的先進理工学研究基盤の形成 2012/09

  66. Chemical Biology of Glycoside Natural Products International-presentation Invited

    UEDA Minoru

    The Second Asian Chemical Biology Conference (ACBC2) 2012/07

  67. 天然物ケミカルバイオロジー:生物現象と天然物リガンド Invited

    上田 実

    名古屋大学IGERグリーン自然科学レクチャー 2012/06

  68. 配糖体型天然物リガンドのケミカルバイオロジー Invited

    上田 実

    日本化学会第92春季年会特別企画「天然物ケミカルバイオロジー」 2012/03

  69. 食虫植物と眠る植物-不思議な生物現象の化学- Invited

    上田 実

    東北大学理学部開講100周年記念公開シンポジウム100+1=∞ 未来を作るサイエンス 2012/03

  70. 眠る植物と食虫植物の科学-不思議な生物現象の化学- Invited

    上田 実

    未来の科学者養成講座公開講演会 2012/02

  71. 生物現象を誘起する新規内因性分子作用機構 Invited

    上田 実

    新学術領域研究 天然物ケミカルバイオロジー 第1回公開シンポジウム 2012/01

  72. 生理活性グリコシドの天然物ケミカルバイオロジー Invited

    上田 実

    東北大学グローバルCOEシンポジウム 2011/11

  73. 食虫植物ハエトリソウの捕虫運動とジャスモン酸グルコシド Invited

    上田 実

    第84回日本生化学会(京都)シンポジウム「食虫植物から探る植物の形態・機能進化の分子機構」 2011/09

  74. 生物現象とグリコシド天然物 Invited

    上田 実

    ERATO伊藤プロジェクトシンポジウム 2011/07

  75. ジャスモン酸グリコシドと植物の運動 Invited

    上田 実

    第6回化学生態学研究会 2011/06

  76. 植物の生物現象と天然物ケミカルバイオロジー Invited

    上田 実

    第91回日本化学会春季年会シンポジウム ケミカルバイオロジーの分子基盤 2011/03

  77. 植物の生物現象と天然物ケミカルバイオロジー Invited

    上田 実

    日本農芸化学会関東支部シンポジウム 2011/01

  78. Target profiling of bioactive metabolite based on a stereospecific ligand recognition: chemical biology of plant nyctinasty International-presentation Invited

    UEDA Minoru

    Molecular Complex Systems: Reversible Aggregation/Disaggregation of Organic Molecules (#216) in Pacifichem 2010 2010/12

  79. 生物現象を誘起する天然物の作用機構 Invited

    上田 実

    化学系学協会東北大会 2010/09

  80. 植物就眠運動のケミカルバイオロジー:天然物有機化学からの展開 Invited

    上田 実

    日本植物学会シンポジウム、「ケミカルバイオロジーが拓く植物科学の未来〜新奇な生理活性化合物で生命活動を探る〜」 2010/09

  81. Chemical genetics of biological phenomenon: Nyctinastic movement of plants International-presentation Invited

    UEDA Minoru

    Chem-Bio-Informactics Society 2009 2009/11

  82. 生物現象を制御するグリコシル化分子のケミカルバイオロジー Invited

    上田 実

    日本化学会東北支部青森地区講演会 2009/11

  83. ジャスミン香気成分誘導体と植物の就眠運動 Invited

    上田 実

    第10回アロマ・サイエンス・フォーラム2009 2009/10

  84. 植物就眠運動を制御するグリコシド型生物活性分子の化学 Invited

    上田 実

    日本生物工学会北日本支部仙台シンポジウム グライコバイオテクノロジー―糖と酵素が織りなすサイエンスとバイオテクノロジーの魅力と可能性― 2009/08

  85. Recent advances on chemical biology of plant nyctinasty International-presentation Invited

    2008 RIKEN Conference on Chemical Biology 2008/11/15

  86. 化学が解き明かす植物の眠りのしくみ Invited

    第6回化学イノベーションシンポジウム:明日をひらく化学のとびら 2008/08/05

  87. エナンチオ・ディファレンシャル法による植物の運動の生物有機化学 Invited

    特定領域研究「生体機能分子の創製」とりまとめシンポジウム 2008/06/15

  88. 生理活性天然物のエナンチオマー対を利用した植物生理現象のケミカルバイオロジー Invited

    日本化学会第88回春期年会シンポジウム ケミカルバイオロジー研究の最前線—生体システムへのアプローチ- 2008/03/25

  89. 青い花の色素と植物の運動:動的天然物と生物有機化学 Invited

    磯部稔先生退職記念公開講演会 2008/03/15

  90. 自然の巧みに学ぶ天然物有機化学 Invited

    東北大学100周年記念講演会 青葉山サイエンススクール 2007/08/22

  91. 天然有機化合物を用いるケミカルバイオロジーと生物現象の分子メカニズム

    万有札幌シンポジウム「環境調和型合成あるいはグリーンケミストリー」(札幌) 2007/07/07

  92. Chemical Factors Inducing Leaf-movement in Leguminosae and Carnivorous Plant International-presentation Invited

    3rd International Symposium on Plant Neurobiology 2007/05/14

  93. 植物の「運動」と「記憶」を制御する生理活性天然物のケミカルバイオロジー Invited

    福岡万有シンポジウム「ケミカルバイオロジーを支える有機合成化学」(福岡) 2007/05/12

  94. 眠る植物と食虫植物の科学—不思議な生物現象の化学— Invited

    東北大学サイエンスカフェ(仙台) 2007/03/15

  95. Natural Products Chemistry of Plant Movement-Molecular Dynamism Inducing Biological Phenomenon- International-presentation Invited

    3rd Yoshimasa Hirata Memorial Lecture 2007/02/06

  96. Molecular probe methods exploring the molecular basis of plant movement International-presentation Invited

    Post-Conference of The 1st International Conference of Cutting-Edge Organic Chemistry in Asia 2006/10/21

  97. 食虫植物-ハエトリグサはどうやって虫を捕まえる? Invited

    東北大学植物園公開市民講座スコラボタニカ『奇妙で不思議な植物の世界を探検する』(仙台) 2006/10/13

  98. 植物の生命現象をコントロールする配糖体型生理活性物質と多糖類の生物有機化学 Invited

    グライコサイエンス若手の会(仙台) 2006/08/26

  99. Molecular basis of plant movements International-presentation Invited

    International COE Symposium for Young Scientists on Frontiers of Molecular Science 2006/08/25

  100. 眠る植物と食虫植物の生物有機化学

    日本化学会東北支部第29回教師のための化学教育講座(仙台) 2006/08/20

  101. 植物はなぜ眠るのか Invited

    第25回天然物化学国際会議・第5回生物多様性国際会議 日本学術会議市民公開講座 「文化としての天然物化学–身近な生物現象の化学—」(京都) 2006/07/27

  102. BIOORGANIC STUDIES ON PLANT MOVEMENT: FROM BIOACTIVE NATURAL PRODUCT TO ITS RECEPTOR International-presentation Invited

    ICOB-5&ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products 2006/07/23

  103. Bioorganic chemistry of the action plants: circadian rhythmic movement and "memory" in higher plants International-presentation Invited

    ICOB-5&ISCNP-25 Pre-Symposium on Bioorganic Chemistry and Chemical Biology 2006/07/21

  104. 植物の運動と記憶に関与する物質をとる Invited

    農芸化学会関東支部例会「現象を操る分子をとるーものとりの極みー」(東京) 2006/06/15

  105. 植物の運動と“記憶”に関与する生体機能分子 Invited

    特定領域研究第2回公開シンポジウム(仙台) 2006/06/14

  106. 眠る植物と食虫植物の科学—不思議な生物現象をコントロールする分子− Invited

    第159回生命科学フォーラム、大正製薬株式会社後援(東京) 2006/04/14

  107. 「植物の運動」に見る生物現象解明への生物有機化学的アプローチ Invited

    2006農化大会共通シンポジウムChemical & Molecular Biology にみる農芸化学の再発見と未来 2006/03/25

  108. 生物の未解明現象と生物有機化学−植物の運動と“記憶”のしくみ− Invited

    日本化学会東北支部講演会(仙台) 2006/02/15

  109. 「動く植物」の生物有機化学—生理活性分子から受容体まで

    理研シンポジウム「第17回 生体分子の化学」(和光) 2006/01/18

  110. Bioorganic chemistry of the action plants: circadian rhythmic movement and "memory" in higher plants International-presentation Invited

    Advances in Natural Product Chemistry: In Honor of Professor Nakanishi's 80th birthday (#303) in Pacifichem 2005 2005/12/10

  111. 植物の運動と“記憶”のしくみ−未解明現象と生理活性物質− Invited

    農林水産省公開講演会 シーズ培養研究の成果—動物・植物・酵素分野のトップランナーが語る− 2005/11/10

  112. 植物の「記憶」現象に関与する生理活性物質 Invited

    中部化学連合秋季大会(静岡) 2005/09/20

  113. Bioorgsnic Studies in Plant movement: Nyctinastic Plant and Insectivorous Plant International-presentation Invited

    2nd Yamada Symposium 2005/09/10

  114. 生物現象解明を目指す天然物化学の新潮流—植物の生理現象を例としてー

    生体関連シンポジウム(広島) 2005/08/26

  115. ダーウィン以来の謎「動く植物」に挑む分子科学 Invited

    東北大学100周年記念セミナー(東京) 2005/04/21

  116. オジギソウとハエトリグサの化学 Invited

    大学と科学シンポジウム、生物現象鍵物質−不思議な生物現象の化学−(大阪) 2005/01/23

  117. 植物の運動に関する生物有機化学 Invited

    日本薬学会東北支部 有機化学若手セミナー(仙台) 2004/09/12

  118. Bioorganic Studies on Plant Leaf-movement–Chemical Mechanism of “Sleep” and “Memory” in Plants International-presentation Invited

    3rd Singapore International Chemical Conference 2003/12/15

  119. 植物の就眠運動と記憶現象に関与する生理活性物質と生物有機化学 Invited

    理研シンポジウム「第4回 分析・解析技術と化学の最先端」(和光) 2003/12/15

  120. 就眠運動の生物有機化学−ポストゲノムの先に天然物化学者が目指すもの Invited

    平成15年度日本農芸化学会中部支部若手シンポジウム「ポストゲノム時代の天然物化学」(静岡) 2003/12/10

  121. 植物の「睡眠」と「記憶」に関与する化学物質−化学で迫る生物の謎 Invited

    読売新聞大阪本社主催東京テクノフォーラム21ゴールドメダル賞受賞記念講演(大阪) 2003/09/10

  122. 植物の「睡眠」と「記憶」に関与する化学物質−化学で迫る生物の謎 Invited

    読売新聞東京本社主催東京テクノフォーラム21ゴールドメダル賞受賞記念講演(東京) 2003/07/15

  123. 植物の運動をコントロールする化学物質と植物の生活環制御 Invited

    新規素材探索研究会第2回セミナー(横浜) 2003/05/11

  124. 植物就眠運動への生物有機化学的アプローチ Invited

    第11回日本農芸化学会若手シンポジウム(東京) 2003/04/03

  125. 眠る植物の不思議と体内時計−ダーウィン以来の謎に挑んで− Invited

    甲南大学理工学部フォーラム「宇宙の不思議、生物の不思議」(神戸) 2002/11/20

  126. 葉の就眠運動 Invited

    日本植物学会第66回大会シンポジウム「動く植物−その謎解き」(京都) 2002/09/15

  127. Bioorganic Studies on Plant Leaf-movement Controlled by a Biological Clock International-presentation Invited

    Japan-Korea Young Scientists Meeting on Bioorganic and Natural Products Chemistry 2002/09/08

  128. 低分子生理活性物質の分離とそれによる生物現象への新しいアプローチ−マメ科植物の就眠運動を例として− Invited

    DNA研究会(渡辺 格主催、東京) 2002/09/05

  129. Chemical Studies on Plant Leaf-movement Controlled by a Biological Clock International-presentation Invited

    IUPAC - 23rd International Symposium on the Chemistry of Natural Products 2002/07/28

  130. 生理活性プローブ化合物を用いたマメ科植物就眠運動の生物有機化学的研究 Invited

    蛋白研セミナー(大阪)、「タンパク質と低分子鍵物質の相互作用解明を目指した化学合成」 2002/07/22

  131. Chemical substance concerning the leaf-movement of Dionaea muscipula International-presentation Invited

    The Fourth International Carnivorous Plant Conference 2002/07/21

  132. マメ科植物就眠運動の生物有機化学的研究 Invited

    日本農芸化学会2002年度大会(仙台)シンポジウム「ライフサイエンスと有機化学」 2002/03/27

  133. マメ科植物の就眠運動を活用した環境調和型新規農薬の開発 Invited

    テクニカルショー横浜 2002/02/12

  134. 就眠運動を利用した環境調和型農薬 Invited

    慶應テクノモール2001 2001/12/10

  135. マメ科植物就眠運動に関する動的天然物化学 Invited

    日本化学会北海道支部主催化学セミナー「21世紀の基礎有機化学」(札幌) 2001/11/21

  136. マメ科植物の就眠運動を活用した環境調和型新規農薬の開発 Invited

    先端科学技術ビジネス塾、丸の内シティキャンパス 2001/06/11

  137. 植物の運動を支配する鍵化学物質の生物有機化学的研究 Invited

    文部省科学研究費補助金特定領域研究(A)第二回公開シンポジウム(東京) 2001/05/23

  138. 植物の感覚と運動に関与する天然有機化合物の化学 Invited

    第35回天然物化学談話会(伊豆) 2000/07/15

  139. 日本化学会進歩賞受賞講演 植物の感覚と運動に関与する天然有機化合物の生物有機化学的研究 Invited

    日本化学会第78春期年会(船橋) 2000/03/25

  140. 植物の運動をコントロールする天然有機化合物 Invited

    日本農芸化学会関東支部シンポジウム「化学と生物のインターフェース-モノと生命現象を見つめる」 1999/06/23

  141. 植物の運動をコントロールする化学物質 Invited

    日本化学会第75秋季年会(松山)若い世代の特別講演会 1998/09/25

  142. 植物の運動をコントロールする化学物質 Invited

    日本農芸化学会1998年度大会(名古屋)シンポジウム「植物のシグナル伝達とシグナル伝達研究の新展開」 1998/03/25

  143. 植物の運動をコントロールする化学物質 Invited

    文部省科学研究費補助金特別推進研究「植物の運動と感覚に関する化学的研究」第1回公開シンポジウム 1997/12/10

  144. 化合物潜在空間のための天然物核内受容体リガンドライブラリーの構築 Invited

    上田 実

    学術変革領域「化合物潜在空間」第2回公開シンポジウム(仙台) 2024/06/12

  145. 化合物潜在空間のための天然物核内受容体リガンドライブラリーの構築 Invited

    上田 実

    学術変革領域研究(A)「天然物が織り成す化合物潜在空間が拓く生物活性分子デザイン」キックオフシンポジウム 2023/08/09

  146. 植物の生態と化学物質:植物の化学コミュニケーション、植物の運動 Invited

    上田 実

    東北植物学会第6回大会 2016/12

Show all Show first 5

Research Projects 28

  1. chemical biology of natural products Competitive

    System: Basic Science Research on Life Science

    2011/10 - Present

  2. 天然物が織り成す化合物潜在空間が拓く生物活性分子デザイン

    菊地 和也, 榊原 康文, 伊藤 寛晃, 丹羽 節, 荒井 緑, 大森 建, 大上 雅史, 上田 実, 鎌田 真由美, 吉田 稔

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 学術変革領域研究(A)

    Institution: 大阪大学

    2023/04/01 - 2028/03/31

  3. Artificial feedback technology to understand the genetic redundancy

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2021/07/09 - 2023/03/31

  4. Chemical biology of natural products on plant hormones

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2020/04/01 - 2023/03/31

  5. Regulation of plant hormone receptor using stereochemical isomers of a natural product

    UEDA Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Institution: Tohoku University

    2019/02/07 - 2022/03/31

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    A stereoisomer library of phytotoxins was constructed by chemical synthesis, and a comprehensive evaluation of their affinity for phytohormone receptor subtypes and their biological activity was conducted in an international collaboration with CNB-CSIC, Spain. The stereoisomer library was evaluated using three plant species, Arabidopsis thaliana, tomato, and rice, and we succeeded in finding stereoisomers each showing unique selective affinity to nuclear receptor subtypes. In this study, we focused on stereoisomers that showed affinity to the receptor subtypes in Arabidopsis thaliana and analyzed their mechanisms of action in detail. As a result, we succeeded in developing molecules that selectively activate receptor subtypes of phytohormone receptors that are involved in the induction of plant resistance to microbial infection.The molecule selectively activates only a portion of phytohormone signaling, while suppression of gene expression does not occur to any degree.

  6. Studies on chemical communication on host-selective toxins

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Institution: Tohoku University

    2017/06/30 - 2022/03/31

  7. Frontiers in Chemical Communications

    Kakeya Hideaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Institution: Kyoto University

    2017/06/30 - 2022/03/31

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    Essential roles of natural products as chemical communication molecules among microbes, animals, plants, et cetera have not been fully elucidated. In this research project, we established the innovative high-order analysis platforms including bioimaging, chemical proteomics, chemical genetics/genomics, and AI-driven bioinformatics, clarifying essential roles of natural products/bioactive synthetic ligands as chemical communication molecules in the natural environment. In addition, this research project contributed to the advancement in medical, agricultural, and food sciences by developing useful chemical tools as well as pharmaceuticals/agrochemicals leads, opening up a new discipline, “Molecular Sociology”, which focuses on the frontiers in chemical communications in a variety of biological species. We also performed an international collaboration, leading to international network development and bringing up young scientist broader views and higher expertise.

  8. Chemical regulation of the transport substrate switching phenomenon in the plant multifunctional transporter GTR1

    Ueda Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2018/06/29 - 2021/03/31

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    The plant membrane transporter protein GTR1 was first discovered as a glucosinolate transporter, but was later found to also function as a transporter of two plant hormones. In order to elucidate the mechanism of using these structurally completely different substrates, we evaluated various transport activities using mutant proteins and an evaluation system using African clawed frog oocytes. The results suggest that GTR1 has the ability to transport both as a dimer and as a monomer, but that there are multimers corresponding to the substrates.

  9. Chemical biology of natural products involved in plant-microbe interaction

    Ueda Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    We constructed a flexible synthetic route to supply all possible stereoisomers of coronatine and constructed a compound library consisting of all 16 stereoisomers of coronatine. Next, the affinities of the isomers in this stereoisomer library for each receptor subtype were comprehensively evaluated by COI1-JAZ co-receptor subtype affinity test. As a result, one of the 16 stereoisomers was an agonist with high selectivity for COI1-JAZ9. This stereoisomer was found to selectively activate the defense response and not induce other responses. Therefore, it is possible that COI1-JAZ9, and thus, we were able to comprehensively identify defense-response-related genes that function downstream of COI1-JAZ9.

  10. Chemical biology of multifunctional transporter GTR1

    Ueda Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2016/04/01 - 2018/03/31

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    Spatiotemporal distributions of plant hormones are regulated strictly through corresponding transporter proteins. GTR1 was found first found as a transporter of a jasmonoyl isoleucine (JA-Ile) and belongs to a NPF family to which 53 member proteins belong. Surprisingly, further studies strongly suggested that GTR1 is a unique `multi-functional` transporter which can transport three different kinds of plant metabolites, JA-Ile, gibberelin, and glucosinolate, across the membrane with structure recognition. We also found that the homo-dimerization of GTR1 is responsible for glucosinolate transport and heterodimerization with other NPF family protein is responsible for the transport of JA-Ile and GA. This is the first example of dimerization-mediated switching of substrate for transporter.

  11. Molecular mechanism of plant nyctinasty

    Ueda Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    The circadian leaf opening and closing (nyctinasty) of Fabaceae has attracted scientists’ attention since the era of Charles Darwin. Nyctinastic movement is triggered by the alternate swelling and shrinking of motor cells at the base of the leaf. This in turn is facilitated by changing osmotic pressures brought about by ion flow through anion and potassium ion channels. However, key regulatory ion channels and molecular mechanisms remain largely unknown. Here, we identify three key ion channels in mimosoid tree Samanea saman: the slow-type anion channels, SsSLAH1 and SsSLAH2, and the Shaker-type potassium channel, SPORK2. We show that cell-specific circadian expression of SsSLAH1 plays a key role in nyctinastic leaf opening. In addition, SsSLAH1 co-expressed with SsSLAH2 in flexor (abaxial) motor cells promoted leaf opening.

  12. Exosome-mediated intercellular chemical signals

    Ueda Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2014/04/01 - 2016/03/31

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    The search for novel bioactive substance becomes more difficult. We focused on an exosome which is known as a liposomal transport system between cells like a "message in a bottle" between cell. We purified mammalian liposome and tried to analyze the involved secondary metabolites. However, the huge amount of biomolecules, such as RNAs, make the MS-analysis difficult.

  13. Mode-of-action of endogenous factor controlling biological phenomena

    UEDA Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Institution: Tohoku University

    2011/04/01 - 2016/03/31

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    Our most important achievement is to show that a stereoisomer of natural products is most useful for tuning the target selectivity. Usually, natural product have plural target and functions as a multi-biofunctional molecule. natural product behave like a bunch of keys, not a canonical lock-and-key. We can reduce the side reactions in the body by using a stereoisomer of natural products. We demonstrated the successful example of target tuning of natural products in plant hormone mimicking natural product, coronatine.

  14. Chemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    2011/04/01 - 2016/03/31

  15. Molecular mechanism of trap-snapping movement of carnivorous plant

    UEDA Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2012/04/01 - 2014/03/31

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    We synthesized four stereo-hybrids of molecular probe bbased on the structure of JAG. JAG promotes ROS production in Samanea motor cell, a model motor cell of plant, and then activate outward-directed K+-channel. However, different mechanism can be involved in the rapid leaf-closure of Dionaea.

  16. Intracellular glycoside signal participating in the regulation of biological phenomena

    UEDA Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2011/04/01 - 2014/03/31

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    JAG induced motor cell shrinking and concomittant ROS production. External addition of ROS also induced motor-cell shrinking, thne JAG-induced shrinking of motor cell is independent to COI1-JAZ signaling pathway and dependent ROS-mediated path. The molecular target of JAG was also revealed by using our compact molecular probe approach.

  17. 寄生植物ナンバンギセルの寄生誘導因子に関する生物有機化学

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的萌芽研究

    Institution: 東北大学

    2009 - 2010

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    ハマウツボ科のナンバンギセルは、最も有名な寄生植物である。ナンバンギセルは葉緑素を持たないため光合成を行わず、ススキ(Miscanthus sinensis)などのイネ科植物の根に寄生し、そこから養分を取り生育する。ナンバンギセルは、イネ科やカヤツリグサ科と特異性の高い寄生関係にあるため、その寄生にはストリゴラクトン類と異なる未知の共生因子の存在が予想された。ごく最近、申請者らは、AM菌とミヤコグサの共生に関与するストリゴラクトン類の一種である5-デオキシストリゴールを化学合成した。ナンバンギセルの寄生が、既知のストリゴラクトン類によるものとどのように異なるのか興味深い。 ナンバンギセルの発芽誘導物質は、そのホスト植物であるススキの根から分泌される。根分泌成分の吸着回収成分を原材料とする活性物質の精製を進める。生物活性分子の分離は、ナンバンギセルの種に対する発芽誘導潜性を指標とした生物検定試験に基づいて行う。ミヤコグサ(Lotus japonicus;マメ科モデル植物)やシロイヌナズナ(Arabidopsis thaliana;アブラナ科モデル植物)の種子を用いる対照試験を同時に行うことで、ナンバンギセルの種子に特異的な発芽誘導活性を示す物質を探索した。目的とする活性物質は、水溶性の高い成分であるが分離法の確立には至っていない。

  18. Bioorganic studies on membrane protein involved in the regulation of plant ion channels

    UEDA Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2008 - 2010

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    We demonstrate that leaf-closure of isolated Samanea pinnae is induced upon stereospecific recognition of (-)-LCF, but not by its enantiomer,(+)-ent-LCF.(-)-LCF was completely inactive with respect to activation of typical JA responses, such as induction of JA-responsive genes, or accumulation of plant volatiles, generally considered to be mediated by JA-Ile in a COI1-dependent fashion.

  19. 植物の重金属イオン補足分子の分子科学的研究に関する研究

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    Institution: 東北大学

    2007 - 2008

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    植物を利用した重金属イオン捕捉による環境浄化(ファイトレメディエーション)が注目されている。しかし、ファイトレメディエーションの分子的実体が解明された例は少なく、その分子基盤の解明が望まれている。カシワのドングリには、構造未知の重金属イオン捕捉分子acornic acidが含まれていると報告された。これは、各種の重金属イオンと共にウラニウムを効率的に捕捉する活性があるとされ、応用的側面からも非常に興味深い。我々は、主として北海道でカシワドングリを大量に採集し、これに含まれる重金属イオン捕捉分子の探索研究を行った。探索の指針として、検出・定量方法が豊富な3価鉄イオン捕捉活性(シデロフォア活性)を指標とすることにした。種々検討の結果、タイロンによるFe^<3+>イオン捕捉活性を指標として再現性の良い検定法を確立し、抽出液の分離条件を検討した。しかし、ポリマー系充填剤、ゲル濾過、逆層ODS系など数種のクロマト充填剤による分離を検討したが、いずれの充填剤を用いた場合にも、活性は特定の画分に集中せず、分散する傾向が見られた。これは、植物成分であるポリフェノール類に典型的な挙動と考えられた。また、分離の過程で、目的分子は、既知のシデロフォア類とは全く異なるイオン捕捉活性を示すことが明らかになった。捕捉イオン量から推定して、目的分子は非化学量論的にイオンを吸着していると考えられた。その特異な捕捉機構も興味深い。(604文字)

  20. 非天然型機能性生理活性分子を用いたマメ科植物就眠運動の生物分子化学的研究

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究

    Institution: 東北大学

    2004 - 2008

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    一般に植物は動かないものと考えられているが、マメ科植物は、昼間は葉を開き、夜になると葉をたたんで「眠る」、就眠運動と呼ばれる特異な生物現象を行う。これは、紀元前、アレキサンダー大王の時代から知られている、非常に興味深い現象である。本研究では、これらの興味深い生物現象を、分子レベルでの解明を試みた。 我々は、マメ科植物の就眠運動は、就眠・覚醒両物質によってコントロールされており、それらが属特異的であることを見いだしている。そこで、Albizzia属アメリカネムノキの就眠・覚醒物質に蛍光色素を結合させた蛍光プローブを合成し、2つの活性物質の作用部位を調べた結果、就眠・覚醒両物質は、葉枕部内側の運動細胞に偏在する受容体に結合することで、葉枕の片側の運動細胞のみに体積変化を引き起こし、これを膨潤・収縮させることがわかった。さらに、就眠物質の両エナンチオマーの蛍光プローブを用いた蛍光標識実験「エナンチオ・ディファレンシヤル分子プローブ法」により、葉枕内側の運動細胞に、就眠物質の立体化学を認識する受容体が含まれることを強く示唆する結果を得た。一方、Lespedeza属メドハギの運動のリズムをつくりだす鍵酵素β-グルコシダーゼの精製に成功し、これが分子量150kDaの巨大な糖タンパク質であることを明らかにした。

  21. 電子顕微鏡観察用プローブを用いた生理活性物質受容体の細胞内局在性に関する研究

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    Institution: 東北大学

    2005 - 2006

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    就眠運動の制御に関与する活性物質受容体については、覚醒物質イソレスペデジン酸カリウムを用いた系での研究が進んでいる。イソレスペデジン酸カリウムを母核とした光親和性プローブを用いて、運動細胞膜画分から、受容体候補として非常に有力な分子量約210kDa、180kDaの2種の巨大な膜タンパク質が発見された。しかし、受容体タンパク質の細胞内局在性については未知であった。本研究では、イソレスペデジン酸カリウムを母核とした骨格に、光親和性基ベンゾフェノン、抗原としてFITCを導入したTEMプローブを合成した。このプローブは、標的細胞上の受容体タンパク質に対して、光化学反応により共有結合的にクロスリンク形成し、これを抗原標識化することができる。対応する抗FITC抗体し、ナノゴールド粒子を結合させることで、電子顕微鏡を用いた免疫電顕法による受容体の直接観察を行った。その結果、受容体分子が運動細胞表面の原形質膜上に存在することを示す結果が得られた。イソレスペデジン酸カリウムは、細胞外から細胞膜上の受容体に作用することでその膨圧変化を引き起こし、葉の運動を引き起こすことが明らかになった。本研究により、ミクロな活性物質をツールとすることで、マクロな生物個体の生理現象が起こる仕組みを、タンパク質、細胞、組織レベルで解明することができた。

  22. ゲノム生物学との融合を目指したマメ科植物就眠運動の生物分子科学

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究(A)

    2003 - 2005

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    就眠・覚醒物質の濃度バランスは配糖体型活性物質のβ-glucosidaseによる分解により制御されており、就眠運動に関する研究を生物時計へと展開していくためには、本酵素の精製・クローニングが重要である。阻害活性が高いグルコノアミジン骨格に覚醒物質イソレスペデジン酸のアグリコン部を導入したグルコノアミジン型阻害剤を合成し、これをリガンドとしたアフィニティークロマトによる目的酵素の精製を計画した。無保護チオノラクタムをNBSにより活性化する簡便な新規アミジン合成法の開発により、グルコノアミジン型覚醒物質の合成に成功した^<1)>。これをリガンドとしたアフィニティーゲルを合成し、粗酵素溶液の精製を行ったところ、1M D-グルコース溶出画分は強いβ-glucosidase活性を示し、SDS-PAGEでほぼ単一なバンドを与えた。 また、光親和性基および抗原となるFITCを導入した電子顕微鏡観察用プローブ(EMプローブ)を開発した。EMプローブ分子中には、光親和性基ベンゾフェノンの光励起によって影響を受けないFITC基を抗原として導入した。これを用いて、昨年度、同定に成功した活性物質受容体(210&180kDa)が、運動細胞原形質膜状に存在することをナノメートルスケールで直接観察することに成功した。これによって、活性物質の生体内ダイナミズムに関する重要な知見が得られた。 また、マメ科モデル植物としてゲノム情報の解析が進むミヤコグサについて活性物質の探索を行った。再現性の良い生物検定法の開発に成功し、これを指標に、採集したミヤコグサ15kgから覚醒活性を示す物質を分離した。活性物質は^1H NMRからポリヒドロキシ化合物と推定されたが、現在のところ構造決定には至っていない。

  23. 植物の運動と「記憶」に関与する化学物質

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究

    Institution: 慶應義塾大学

    2001 - 2002

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    (1)合成プローブを用いた就眠運動の生物有機化学 我々は、覚醒物質レスペデジン酸カリウムを基盤として蛍光プローブ化合物を開発し、活性物質の標的細胞が運動に際して膨潤・収縮する運動細胞であることを明らかにした。また、その結合は非ラベル体の共存下では完全に阻害され、活性物質の運動細胞への結合は構造特異的であることも示した。 この知見を基に光親和性プローブを開発した。我々は、光親和性基と活性部位が空間的に近接し、高い結合活性を期待できる2位修飾型プローブを合成した。運動細胞を含むカワラケツメイの葉枕部位を実体顕微鏡下で切断、これをホモジナイズし、超遠心分離によって膜画分を集め、光ラベル化実験に付すことで、活性物質結合タンパク質と見られるバンドを検出した。 就眠運動に関与する活性物質は、植物属特異的な生物活性を示し、植物属ごとに異なる受容体の存在が予想された。我々は、国内で複数の同族植物が入手可能なAlbizza属に属するネムノキの覚醒物質cis-p-coumaroylagmatineを基盤とした蛍光プロープ化合物を開発した。この蛍光プローブはネムノキ、及びこれと同族のAlbizzia属植物には結合するが、他属植物の運動細胞には全く結合せず、マメ科植物の運動細胞には、属内で共通の受容体が関与することが強く示唆された。 (2)ハエトリソウの記憶現象に関与する化学物質 食虫植物ハエトリソウの補虫運動に見られる記憶現象に、化学物質が関与していることを発見し、活性物質の精製を検討した。 活性物質の精製には、化学修飾ポリビニルアルコール系充填剤Asahipak ODPを用いたHPLCを用いた。ハエトリソウ中には高分子量と低分子量(現在数十μg)の2種の活性物質が含まれ、このうち低分子量の物が活性本体と考えられた。高分子量画分の主成分はデオキシ糖を含む酸性多糖類であると推定された。

  24. Bioorganic studies on nyctinastic leaf-movement controlled by a biological clock

    UEDA Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Keio University

    2000 - 2002

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    Most leguminous plants close their leaves in the evening, as if to sleep, and open them early in the morning. This circadian rhythm is known to be controlled by a biological clock of such plants. Extensive studies on some nyctinastic plants led to the isolation of a variety of leaf-closing and leaf-opening substances. And we found that a biological clock regulates the balance of concentration between leaf-opening and -closing substances in the plant body through the activation of β-glucosidase and generates the circadian rhythm of leaf-movement (Figure). Also, we will show two examples of our attempts for the bioorganic studies of plant leaf-movement using synthetic probe compounds. One is the direct observation of the target cell for leaf-movement factor by fluorescence-labeled probe compounds and the other is the chemical study on the historical problem, "Why does the plant sleep?" by using synthetic non-natural natural products that inhibit the leaf closure.

  25. 植物の運動と「記憶」に関与する化学物質

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究(A)

    Institution: 慶應義塾大学

    2000 - 2000

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    1)我々は、ハエトリソウをメタノール水溶液で抽出すると、その抽出液にはハエトリソウの補虫運動(葉の閉鎖運動)を引き起こす活性があることを明らかにした。しかし、分離を行うと活性が容易に消失する事から、この化合物は化学的に不安定であると考えられた。 2)我々は、覚醒物質レスペデジン酸カリウムを基盤とした蛍光プローブ化合物を化学合成した。蛍光補助基として、分子サイズの小さなNBD,AMCA,dansyl基を結合させたプローブ化合物は、天然物にほぼ匹敵する活性を示した。現在、蛍光顕微鏡を用いて、これらプローブ化合物と植物組織との結合の観察について検討している。 3)我々は、化学合成した人工覚醒物質を用いて、植物の就眠運動を阻害することに成功した。そこで、水分蒸散の機構を調べるために、就眠物質により閉じた葉と覚醒物質により開いた葉を用いて、一日の気孔の運動を観察した。その結果、気孔は、葉の開閉と無関係に、昼間は開き、夜には閉じるといった通常通りの開閉運動を行っていることが分かった。これらの結果より、マメ科植物は、就眠運動を行うことで、葉表面のクチクラ層からの水分蒸散を制御しているものと推定された。 4)マメ科植物のギンネムは、小笠原・沖縄地方に分布するマメ科の外来植物であり、他の植物を駆逐して、地域の生態系を乱すことから問題になっている。我々は、葉を開かせる覚醒物質を用いて目的植物のみの就眠運動を阻害し、水分欠乏を誘導して枯死させることで、ギンネムを選択的に除草剤できるのではないかと考えた。そこで、ギンネムの活性物質の単離・構造決定を行い、就眠物質としてPotassium 2,3,4-trihydroxy-2-methylbutanoateを得た。また、抽出液中には覚醒物質による活性も確認されており、現在精製を進めている。

  26. Chemical Studies on movement and sensivility in plants

    YAMAMURA Shosuke, HASEGAWA Koji, UEDA Minoru, KOSEMURA Seiji, TOMITA Kaori yokotani

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Specially Promoted Research

    Institution: Keio University

    1997 - 1999

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    Phototropism has been known to be caused by a lateral gradient of growth-promoting auxin in the bending organ (Cholodny-Went theory). In contrast to the C.-W. theory, Brinsma and Hasegawa recently found that the shaded half did not contain more auxin than the illuminated ones. Instead it was found that the even distribution of auxin was accompanied by a lateral gradient of growth inhibitory substances during phototropic curvature. We have isolated some photo-induced growth inhibitory substances related to phototropism. 6-Methoxy-2- benzoxazolinone from light-grown maize (Zea mays L.) shoots was proved to inhibit the interaction between auxin and ABP1, the primary structure of which was determined, resulting in the growth inhibition in the illuminated side. Our present study has led to a new theory of "phototropism". Many plants close their leaves at night and open during daytime. Such a circadian rhythm has been known to be controlled by their internal clock. We were able to isolate each pair of leaf-closing and -opening substances from five different species. Of the pair, one of them was found to be β-D-glucoside. The leaf movement of these plants is due to the balance of concentration between them, which is controlled by the activation of β-D-glucosidase. Based on our extensive study, a new mechanism of leaf movement has been presented. In the case of Mimosa pudica, we could isolate a true active stimulant (activity : ca. 10-8〜10-9M) from the same plant, which consists of three components (potassium L-malate, magnesium transaconitate and dimehylammonium salt) in addition to the pair of leaf-closing and opening substances related to circadian rhythm.

  27. マメ科植物カワラケツメイの行う就眠運動の分子機構

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 奨励研究(A)

    Institution: 慶應義塾大学

    1997 - 1997

  28. ネムノキの就眠運動を支配する化学物質に関する研究

    上田 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 奨励研究(A)

    Institution: 慶応義塾大学

    1996 - 1996

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    山村・志津里らは夜間でも葉を開かせておく覚醒物質レスペデジン酸カリウム、イソレスペデジン酸カリウムをマメ科植物のメドハギより単離し、従来、葉を閉じさせる物質の濃度変化のみでコントロールされると考えられていた植物の就眠運動が、就眠・覚醒両物質のバランスによって引き起こされる可能性を示唆した。しかし、これに対応するメドハギの就眠物質を得ることが出来ず、この単離・構造決定が待たれていた。申請者は、覚醒物質の場合と同様にカワラケツメイの葉に対する活性を指標として、メドハギ抽出物より1×10^<-7>mol/Lの濃度で有効な就眠物質Potassium D-idarateを単離し、合成により確認した。この物質は、覚醒物質と1×10^<-6>mol/Lの濃度で拮抗作用を示した。さらに、昼夜採集し得られたメドハギ抽出物がそれぞれ開葉・閉葉と逆の生物活性を示したことから、就眠運動はこれら二つの活性物質の濃度バランスの変化によって支配されていることが明らかになった。 また、ネムノキは、就眠運動を行う植物としてもっとも著名であるが、従来法での生物検定が適用できず、研究は困難であった。申請者は、新たに開発したネムノキの幼葉を用いた生物活性試験を指標として、1×10^<-5>mol/Lの濃度で有効な覚醒物質cis-p-coumaroylagmatineを単離・構造決定し、化学合成により確認した。これは、オジギソウ、クサネム、コミカンソウに対しては1×10^<-2>mol/Lの濃度でも全く活性を示さなかったが、興味深いことにカワラケツメイに対してのみ1×10^<-2>mol/Lの濃度で活性を示した。現在、この覚醒物質に対応するネムノキの就眠物質の探索を検討している。

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Social Activities 7

  1. おもしろ化学の屋台村

    2006/08/03 - 2006/08/17

  2. NHK「つながるテレビ@ヒューマン」

    2006/08 -

  3. 植物の神秘 鮮やかに解明

    2003/04 -

  4. 植物の就眠運動 謎を解明

    2002/10 -

  5. 環境調和農薬に期待

    2001/03 -

  6. 植物の就眠制御2物質を単離

    2000/12 -

  7. 植物を眠らせる物質を発見

    1998/05 -

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Media Coverage 9

  1. 仙台放送 東北大学100周年物語

    仙台放送

    2007/06

    Type: TV or radio program

  2. 東北大学サイエンスカフェ

    河北新報

    2007/03

    Type: Newspaper, magazine

  3. Nature(オンライン版)インタビュー

    Nature(オンライン版)

    2006/06

    Type: Newspaper, magazine

  4. 仙台放送 科学番組

    2004/10

    Type: TV or radio program

  5. 植物の”眠り”のナゾを解く

    Science&Technology Journal

    2004/06

    Type: Newspaper, magazine

  6. 植物の眠りと記憶

    Newton

    2003/03

    Type: Newspaper, magazine

  7. マメ科植物「ギンネム」の就眠物質の特定に成功

    日本工業新聞

    2001/09

    Type: Newspaper, magazine

  8. 植物を不眠にして枯らす

    日経バイオビジネス

    2001/07

    Type: Newspaper, magazine

  9. 究める オジギソウの就眠物質を発見した

    毎日新聞

    1998/06

    Type: Newspaper, magazine

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Other 27

  1. 生理活性物質の両鏡像体を用いる標的タンパク質探索

    More details Close

    植物の就眠運動に関する基礎研究

  2. 植物の記憶現象の生物有機化学

    More details Close

    植物の記憶現象の生物有機化学

  3. 分子プローブ法による標的タンパク質探索法の開発

    More details Close

    分子プローブ法による標的タンパク質探索法の開発

  4. 就眠分子の標的膜タンパク質の生物有機化学

    More details Close

    就眠分子の標的膜タンパク質の生物有機化学

  5. 旭硝子財団

  6. Mizutani Foundation Grant

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    ハエトリソウ

  7. 武田科学振興財団

    More details Close

    植物の記憶

  8. 上原生命科学財団

    More details Close

    植物の記憶

  9. 財団法人医薬資源研究振興会

  10. 積水化学自然に学ぶものつくりプロジェクト

    More details Close

    植物の記憶

  11. 松藾財団

    More details Close

    植物の記憶

  12. 加藤記念バイオサイエンス研究振興財団研究助成

  13. 倉田奨励金

  14. 守谷育英会研究助成金

  15. 財団法人農芸化学研究奨励会第30回研究奨励金

  16. 稲森財団研究助成

  17. 三島海雲記念財団

    More details Close

    植物の研究

  18. 三菱化学研究奨励基金

  19. 内藤記念科学奨励金

  20. 木原記念生命科学振興財団

    More details Close

    植物の生物有機化学

  21. 実吉奨学会研究助成金

    More details Close

    植物の就眠運動

  22. 神奈川科学アカデミー研究助成

    More details Close

    植物の研究

  23. 住友財団基礎科学研究助成

    More details Close

    植物の生物有機化学

  24. 内藤記念財団

    More details Close

    植物の生物有機化学

  25. バイオテクノロジー先端技術シーズ培養研究

  26. 旭硝子財団奨励研究

    More details Close

    就眠運動に関する生物有機化学

  27. 医薬資源研究振興会

    More details Close

    就眠運動に関する生物有機化学

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