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Kentaro Mizuta

Section

Graduate School of Dentistry

Job title

Professor

Degree

博士（歯学）（東北大学）

researchmap

https://researchmap.jp/read0138550

J-GLOBAL ID

200901095924250789

ORCID

https://orcid.org/0000-0001-8963-9844

Research History 8

2018/11 - Present

Tohoku University Graduate School of Dentistry　Dento-oral Anesthesiology　Professor
2023/04 - 2024/03

Tohoku University　Graduate School of Dentistry　Vice-Dean
2014/05 - 2018/10

Department of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry　Associate Professor
2011/10 - 2014/04

Tohoku University Graduate School of Dentistry　Lecturer
2007/04 - 2011/09

Tohoku University Graduate School of Dentistry　Dento-oral Anesthesiology　Assistant Professor
2005/10 - 2007/08

Department of Anesthesiology, Columbia University College of Physicians & Surgeons　Postdoctoral Research Fellow
2004/04 - 2007/03

Tohoku University Graduate School of Dentistry　JSPS research fellow (PD)
2003/04 - 2004/03

Tohoku University Hospital　Clinical fellow

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Education 2

Tohoku University　Graduate School, Division of Dental Research　Doctoral course

- 2003/03
Tohoku University　Faculty of Dentistry

- 1999/03/31

Committee Memberships 16

日本歯科麻酔学会　常任理事

2021/10 - Present
日本歯科麻酔学会　雑誌編集委員会委員長

2019/11 - Present
歯科医師国家試験委員

2019/04 - 2025/03
宮城県歯科医師会病診連携委員会　参与

2019/04 - Present
日本歯科麻酔学会　代議員（社員）

2013/10 - Present
厚生労働省歯科医師の医科麻酔研修に関する検討会　委員

2022/04 - 2024/03
日本歯科麻酔学会認定医審査委員会　委員

2019/11 - 2022/03
日本歯科麻酔学会国際交流委員会　委員

2019/11 - 2021/10
日本歯科麻酔学会事業企画委員会　委員長

2019/11 - 2021/10
日本歯科麻酔学会　理事

2019/10 - 2021/10
日本歯科麻酔学会倫理審査委員会　委員

2019/10 - 2021/10
日本歯科麻酔学会財務委員会　委員

2018/11 - 2019/10
日本歯科麻酔学会地域医療委員会　委員

2015/11 - 2019/10
日本歯科麻酔学会雑誌編集委員会　編集委員

2015/11 - 2019/10
日本歯科麻酔学会広報委員会　委員

2013/10 - 2019/10
歯科基礎医学会　代議員

2015/09 - 2018/09

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Professional Memberships 9

日本口腔顔面痛学会
American Physiological Society
東日本歯科麻酔学会
日本障害者歯科学会
日本呼吸器学会
歯科基礎医学会
日本歯科麻酔学会
日本麻酔科学会
American Society of Anesthesiologists

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Research Interests 8

口腔顔面痛
オーファンGPCR
慢性閉塞性肺疾患
脳機能モニタリング
人工知能
Parasympathetic reflex
Bronchospasm
Asthma

Research Areas 4

Informatics / Human interfaces and interactions /
Life sciences / Anesthesiology /
Life sciences / Surgical dentistry /
Life sciences / Nutrition and health science /

Awards 9

タニタ健康体重基金研究助成

2019
三島海雲記念財団学術研究奨励金

2018
日本歯科麻酔学会デンツプライ賞

2014/10/10　日本歯科麻酔学会
日本歯科麻酔学会デンツプライ賞

2012/10　日本歯科麻酔学会
一般研究助成

2011/11　テルモ科学技術振興財団
武田科学振興財団医学系研究奨励

2010/06　武田科学振興財団
日本学術振興会国際学会等派遣事業

2009/06　日本学術振興会
上原記念生命科学財団研究奨励金

2009/03　上原記念生命科学財団
第１６回歯科基礎医学会賞

2004/09　歯科基礎医学会

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Papers 66

Diurnal variation in asthma symptoms: Exploring the role of melatonin. International-journal

Haruka Sasaki, Kentaro Mizuta

Journal of oral biosciences　66　(3)　519-524　2024/09

DOI： 10.1016/j.job.2024.06.008 　

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BACKGROUND: Asthma is a common chronic inflammatory disease affecting more than 260 million people worldwide. Nocturnal exacerbations of asthma symptoms significantly affect sleep quality and contribute to the most serious asthma exacerbations, which can lead to respiratory failure or death. Although β2-adrenoceptor agonists are the standard of care for asthma, their bronchodilatory effect for nocturnal asthma is limited, and medications that specifically target symptoms of nocturnal asthma are lacking. HIGHLIGHT: Melatonin, which is secreted by the pineal gland, plays a crucial role in regulating circadian rhythms. Peak serum melatonin concentrations, which are inversely correlated with diurnal changes in pulmonary function, are higher in patients with nocturnal asthma than in healthy individuals. Melatonin potentiates bronchoconstriction through the melatonin MT2 receptor expressed in the smooth muscles of the airway and attenuates the bronchodilatory effects of β2-adrenoceptor agonists, thereby exacerbating asthma symptoms. Melatonin inhibits mucus secretion and airway inflammation, potentially ameliorating asthma symptoms. CONCLUSION: Melatonin may exacerbate or ameliorate various pathophysiological conditions associated with asthma. As a potential therapeutic agent for asthma, the balance between its detrimental effects on airway smooth muscles and its beneficial effects on mucus production and inflammation remains unclear. Further studies are needed to elucidate whether melatonin worsens or improves asthma symptoms.
Differences in prevalence of self-reported oral hypofunction between older adult patients with rheumatoid arthritis and the general older population: A cross-sectional study using propensity score matching. International-journal

Yoko Kudo, Kenji Takeuchi, Taro Kusama, Toshihisa Kojima, Yuko Waguri-Nagaya, Mako Nagayoshi, Katsunori Kondo, Kentaro Mizuta, Ken Osaka, Masayo Kojima

Journal of oral rehabilitation　51　(6)　924-930　2024/06

DOI： 10.1111/joor.13658 　

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OBJECTIVE: To examine the association between rheumatoid arthritis (RA) and oral hypofunction (OHF) using propensity score matching (PSM) to adjust for differences between older adults with RA and the general older adult population. METHODS: We conducted a cross-sectional survey among 189 older adults with RA in 2019 (mean age, 71.9 ± 3.6) and 47 178 independent older adult residents in 2016 (mean age, 71.6 ± 4.0), respectively. The questionnaire covered information on socio-demographic characteristics and OHF for both groups. Age, sex, educational level and smoking history were used to determine PSM. Prevalence ratios (PRs) and 95% confidence intervals (CIs) of self-reported OHF (fewer remaining teeth, decreased masticatory function, deterioration of swallowing function and oral dryness) were estimated using Poisson regressions. RESULT: OHF was observed in 44.4% of patients with RA and 27.5% of residents. Before PSM, the prevalence of OHF among patients with RA was higher than that of residents (PR, 1.75; 95% CI, 1.50-2.05). After PSM, there were 189 patients with RA and residents, and the prevalence of OHF among patients with RA was still higher (PR, 1.61; 95% CI, 1.22-2.13). Poisson regression showed that the prevalence of 19 or fewer teeth (PR, 1.06; 95% CI, 0.82-1.36), difficulties eating tough foods (PR, 1.18; 95% CI, 0.90-1.55), difficulties swallowing tea or soup (PR, 1.77; 95% CI, 1.19-2.63), and dry mouth (PR, 2.79; 95% CI, 1.90-4.07) was higher among patients with RA than residents. CONCLUSION: Compared with the general older adult population, patients with RA have a higher prevalence of self-reported OHF.
Indirect laryngoscopy is more effective than direct laryngoscopy when tracheal intubation is performed by novice operators: a systematic review, meta-analysis, and trial sequential analysis. International-journal

Hiroshi Hoshijima, Takahiro Mihara, Toshiya Shiga, Kentaro Mizuta

Canadian journal of anaesthesia = Journal canadien d'anesthesie　71　(2)　201-212　2024/02

DOI： 10.1007/s12630-023-02642-9 　

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PURPOSE: We sought to perform a systematic review and meta-analysis to determine whether indirect laryngoscopy has an advantage over direct laryngoscopy in terms of the tracheal intubation rate, glottic visualization, and intubation time when used by novice operators. METHODS: We extracted adult prospective randomized trials comparing tracheal intubation with indirect vs direct laryngoscopy in novice operators from electronic databases. We extracted the following data from the identified studies: success rate, glottic visualization, and intubation time. Data from each trial were combined via a random-effects model to calculate the pooled relative risk (RR) or weighted mean difference (WMD) with a 95% confidence interval (CI). We also performed a trial sequential analysis. RESULTS: We included 15 articles (17 trials) comprising 2,290 patients in the systematic review. Compared with the direct laryngoscopy, indirect laryngoscopy improved success rate (RR, 1.15; 95% CI, 1.07 to 1.24; P = 0.0002; I2 = 88%), glottic visualization (RR, 1.76; 95% CI, 1.36 to 2.28; P < 0.001; I2 = 85%), and intubation time (WMD, -9.06 sec; 95% CI, -16.4 to -1.76; P = 0.01; I2 = 98%) in tracheal intubation. Trial sequential analysis showed that the total sample size was sufficient to analyze the success rate and intubation time. CONCLUSION: In this systematic review, we found that the tracheal intubation success rate, glottic visualization, and intubation time were improved when novice operators used indirect laryngoscopy rather than direct laryngoscopy. Trial sequential analysis results indicated that the sample size was sufficient for examining the success rate and intubation time. STUDY REGISTRATION: PROSPERO (CRD42022309045); first registered 4 September 2022.
Machine learning-based identification of the risk factors for postoperative nausea and vomiting in adults. International-journal

Hiroshi Hoshijima, Tomo Miyazaki, Yuto Mitsui, Shinichiro Omachi, Masanori Yamauchi, Kentaro Mizuta

PloS one　19　(8)　e0308755　2024

DOI： 10.1371/journal.pone.0308755 　

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Postoperative nausea and vomiting (PONV) is a common adverse effect of anesthesia. Identifying risk factors for PONV is crucial because it is associated with a longer stay in the post-anesthesia care unit, readmissions, and perioperative costs. This retrospective study used artificial intelligence to analyze data of 37,548 adult patients (aged ≥20 years) who underwent surgery under general anesthesia at Tohoku University Hospital from January 1, 2010 to December 31, 2019. To evaluate PONV, patients who experienced nausea and/or vomiting or used antiemetics within 24 hours after surgery were extracted from postoperative medical and nursing records. We create a model that predicts probability of PONV using the gradient tree boosting model, which is a widely used machine learning algorithm in many applications due to its efficiency and accuracy. The model implementation used the LightGBM framework. Data were available for 33,676 patients. Total blood loss was identified as the strongest contributor to PONV, followed by sex, total infusion volume, and patient's age. Other identified risk factors were duration of surgery (60-400 min), no blood transfusion, use of desflurane for maintenance of anesthesia, laparoscopic surgery, lateral positioning during surgery, propofol not used for maintenance of anesthesia, and epidural anesthesia at the lumbar level. The duration of anesthesia and the use of either sevoflurane or fentanyl were not identified as risk factors for PONV. We used artificial intelligence to evaluate the extent to which risk factors for PONV contribute to the development of PONV. Intraoperative total blood loss was identified as the potential risk factor most strongly associated with PONV, although it may correlate with duration of surgery, and insufficient circulating blood volume. The use of sevoflurane and fentanyl and the anesthesia time were not identified as risk factors for PONV in this study.
Comparison of Indirect and Direct Laryngoscopes in Pediatric Patients with a Difficult Airway: A Systematic Review and Meta-Analysis. International-journal

Risa Takeuchi, Hiroshi Hoshijima, Takahiro Mihara, Shinichi Kokubu, Aiji Sato Boku, Takumi Nagumo, Tsutomu Mieda, Toshiya Shiga, Kentaro Mizuta

Children (Basel, Switzerland)　11　(1)　2023/12/31

DOI： 10.3390/children11010060 　

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This meta-analysis was performed to determine whether an indirect laryngoscope is more advantageous than a direct laryngoscope for tracheal intubation in the setting of a difficult pediatric airway. Data on the intubation failure and intubation time during tracheal intubation were extracted from prospective and retrospective studies identified through a comprehensive literature search. Data from 10 individual articles (11 trials) were combined, and a DerSimonian and Laird random-effects model was used to calculate either the pooled relative risk (RR) or the weighted mean difference (WMD) and the corresponding 95% confidence interval (CI). Meta-analysis of the 10 articles indicated that the intubation failure of tracheal intubation with an indirect laryngoscope was not significantly different from that of a direct laryngoscope in patients with a difficult airway (RR 0.86, 95% CI 0.51-1.46; p = 0.59; Cochrane's Q = 50.5; I2 = 82%). Intubation time with an indirect laryngoscope was also similar to that with a direct laryngoscope (WMD 4.06 s; 95% CI -1.18-9.30; p = 0.13; Cochrane's Q 39.8; I2 = 85%). In conclusion, indirect laryngoscopes had the same intubation failure and intubation time as direct laryngoscopes in pediatric patients with a difficult airway. Currently, the benefits of indirect laryngoscopes have not been observed in the setting of a difficult pediatric airway.
歯科医院で常備すべき救急薬・機器等についての提言

藤澤俊明, 水田健太郎, 望月亮, 松村朋香, 立浪康晴, 杉村光隆

日本歯科医学会誌　42　51-57　2023/03
Publisher: 日本歯科医学会
ISSN： 0286-164X
Successful Tracheal Intubation With Airway Scope After Failure With McGrath. International-journal

Shiori Sasaki, Hiroshi Hoshijima, Makoto Yasuda, Kentaro Mizuta

Anesthesia progress　70　(1)　17-19　2023/03/01

DOI： 10.2344/anpr-69-03-01 　

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The use of video laryngoscopy is growing in patients with anatomical factors suggestive of a difficult airway. This case report describes the successful tracheal intubation of a 54-year-old female patient with limited mouth opening scheduled for third molar extraction under general anesthesia. The Airway scope (AWS) along with a gum-elastic bougie was used to secure the airway after failed direct laryngoscopy and video laryngoscopy using the McGrath MAC with an X-blade. The AWS has a J-shaped structure in which the blade approximates the curvature of the pharynx and larynx. This blade shape makes it easy to match the laryngeal axis with the visual field direction, enabling successful tracheal intubation even for patients with limited mouth opening. A major key to successful video laryngoscopy is to select a video laryngoscope based on the anatomical characteristics of patients with a difficult airway.
Lipopolysaccharide Priming Exacerbates Anaphylatoxin C5a-Induced Anaphylaxis in Mice.

Makoto Yasuda, Yukinori Tanaka, Kanan Bando, Shunji Sugawara, Kentaro Mizuta

Biological & pharmaceutical bulletin　46　(3)　432-439　2023

DOI： 10.1248/bpb.b22-00766 　

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Anaphylaxis is a serious allergic or hypersensitivity reaction with a sudden onset that can be life-threatening or fatal. Previous studies have highlighted two pathways of anaphylaxis in mice. One is the classical immunoglobulin E (IgE)-mediated pathway that involves mast cells and histamine. The other is an alternative IgG-mediated pathway that involves basophils, monocytes/macrophages, neutrophils, and the platelet-activating factor (PAF). However, little is known about the mechanism by which complement anaphylatoxins contribute to the induction of anaphylaxis. Infection is a cofactor that potentially amplifies the risk of anaphylaxis. Here, we showed that priming with a lipopolysaccharide (LPS), which mimics bacterial infection, exacerbates anaphylatoxin C5a-induced anaphylaxis in mice. LPS plus C5a-induced anaphylaxis was mediated by histamine and lipid mediators, especially PAF. Cell depletion experiments demonstrated that LPS plus C5a-induced anaphylaxis depended on monocytes/macrophages, basophils, and neutrophils. These results suggest that C5a is a potent inducer of anaphylaxis in bacterial infections. Remarkably, the molecular and cellular mediators of LPS plus C5a-induced anaphylaxis are mostly shared with IgE- and IgG-mediated anaphylaxis. Therefore, combined inhibition of histamine and PAF may be beneficial as a second-line treatment for severe anaphylaxis.
Severe Bleeding During Orthognathic Surgery for a Noonan Syndrome Patient. International-journal

Haruka Sasaki, Kentaro Mizuta

Anesthesia progress　69　(4)　22-25　2022/12/01

DOI： 10.2344/anpr-69-02-02 　

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Noonan syndrome (NS) is a genetic disorder characterized by craniofacial dysmorphism, chest deformities, congenital heart defects, and bleeding disorders. Although patients with NS have a high prevalence of orofacial deformity, few reports are available on their anesthetic management during orthognathic surgery. This case report describes a 31-year-old female with NS, anemia, hypertrophic cardiomyopathy, and mild mitral valve regurgitation who experienced severe bleeding during orthognathic surgery. After treating her anemia with oral iron therapy and subcutaneous epoetin β, 4 units of autologous blood was deposited prior to surgery. General anesthesia was induced with remifentanil and propofol and maintained with sevoflurane, remifentanil, and fentanyl. Despite mild hypotensive anesthesia (targeted mean arterial pressure of 65 mm Hg) with nitroglycerine and intravenous tranexamic acid for bleeding, adequate hemostasis was difficult to achieve and led to severe blood loss (1442 mL). Therefore, the 4 units of autologous blood and 2 units of packed red blood cells were transfused. Her postoperative course proceeded uneventfully without abnormal postoperative bleeding. Because patients with NS can have difficulty with hemostasis, vascular malformations, and fragile blood vessels, extensive hematologic evaluation and thorough preparation for unexpected bleeding are crucial to accomplish orthognathic surgery.
Nasal protection strategy reduces the incidence of nasal pressure injuries during nasotracheal intubation: Meta-analysis with trial sequential analysis. International-journal

Hiroshi Hoshijima, Takahiro Mihara, Takumi Nagumo, Aiji Sato Boku, Toshiya Shiga, Kentaro Mizuta

Medicine　101　(40)　e30638　2022/10/07

DOI： 10.1097/MD.0000000000030638 　

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BACKGROUND: Nasal pressure injury is a serious problem during nasotracheal intubation. We performed this systematic review and meta-analysis to determine whether use of a nasal protection strategy (a protective dressing or a modified fixation method for the tracheal tube) reduces the incidence of nasal pressure injury during nasotracheal intubation. METHODS: Literature searches were performed using three electronic databases. Data from each of the eligible trials were combined, and calculations were made using DerSimonian and Laird random effects models. The pooled effect estimates for nasal pressure injury were evaluated using the relative risk and 95% confidence interval, the Cochrane Q statistic, and the I2 statistic. We also performed trial sequential analysis (TSA) to assess sensitivity to prevent type I error. We separated patients into subgroups to analyze the incidence of nasal pressure injury according to whether a protective dressing or a modified fixation method for the tracheal tube was used. RESULTS: The literature search yielded five eligible trials. Meta-analysis of these trials showed that a nasal protection strategy significantly reduced the incidence of nasal pressure injury during nasotracheal intubation (relative risk (RR) 0.34; 95% confidence interval (CI) 0.21-0.56; P < .0001; Cochrane's Q = 5.86, I2 = 32%). The TSA boundary for futility could not be calculated because of an insufficient sample size. In subgroup analysis, both methods significantly reduced the incidence of nasal pressure injury during nasotracheal intubation. CONCLUSIONS: The findings of this meta-analysis suggest that a nasal protection strategy significantly reduces the incidence of nasal pressure injury during nasotracheal intubation. During nasotracheal intubation, the use of a protective dressing or modified fixation method for the tracheal tube can prevent to the incidence of nasal pressure injuries. However, the number of samples in our meta-analysis was too small for TSA and further studies are required. TRIALS REGISTRATION: PROSPERO (International Prospective Register of Systematic Reviews; registration number 252091).
Effectiveness of Indirect and Direct Laryngoscopes in Pediatric Patients: A Systematic Review and Network Meta-Analysis. International-journal

Hiroshi Hoshijima, Takahiro Mihara, Shinichi Kokubu, Sakura Takeda, Toshiya Shiga, Kentaro Mizuta

Children (Basel, Switzerland)　9　(9)　2022/08/25

DOI： 10.3390/children9091280 　

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This research aimed to produce a coherent ranking of the effectiveness of intubation devices in pediatric patients using network meta-analysis (NMA). We searched the electric databases for prospective randomized studies that compared different tracheal intubation devices in pediatric patients. The primary outcome was intubation failure at the first attempt. Secondary outcomes were glottic visualization and intubation time. The statistical analysis performed used DerSimonian and Laird random-effects models. Frequentist network meta-analysis was conducted, and network plots and network league tables were produced. Subgroup analysis was performed after excluding rigid-fiberscope-type indirect laryngoscopes. Thirty-four trials comparing 13 devices were included. Most laryngoscopes had the same intubation failure rate as the Macintosh reference device. Only the Truview PCD™ had a significantly higher intubation failure rate than the Macintosh (odds ratio 4.78, 95% confidence interval 1.11-20.6) The highest-ranking laryngoscope was the Airtaq™ (P score, 0.90), and the AirwayScope™, McGrath™, and Truview EVO2™ ranked higher than the Macintosh. The Bullard™ had the lowest ranking (P score, 0.08). All laryngoscopes had the same level of glottic visualization as the Macintosh and only the C-MAC™ had a significantly shorter intubation time. Intubation time was significantly longer when using the GlideScope™, Storz DCI™, Truview PCD™, or Bullard™ compared with the Macintosh. P score and ranking of devices in the subgroup analyses were similar to those in the main analysis. We applied NMA to create a consistent ranking of the effectiveness of intubation devices in pediatric patients. The findings of NMA suggest that there is presently no laryngoscope superior to the Macintosh laryngoscope in terms of tracheal intubation failure rate and glottic visualization in pediatric patients.
Airtraq® versus GlideScope® for tracheal intubation in adults: a systematic review and meta-analysis with trial sequential analysis. International-journal

Hiroshi Hoshijima, Takahiro Mihara, Yohei Denawa, Toshiya Shiga, Kentaro Mizuta

Canadian journal of anaesthesia = Journal canadien d'anesthesie　69　(5)　605-613　2022/05

DOI： 10.1007/s12630-022-02217-0 　

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PURPOSE: In recent years, various types of indirect laryngoscopes have been developed. Nevertheless, no conclusions have been drawn about which type of indirect laryngoscope is most effective for tracheal intubation. We performed a systematic review and meta-analysis to determine whether the Airtraq® or the GlideScope® is more effective for tracheal intubation. METHODS: We extracted studies of adult prospective randomized trials comparing tracheal intubation between the Airtraq and GlideScope. An electronic database was used to extract the studies included in our meta-analysis. We extracted the following data from the identified studies: success rate, glottic visualization, and intubation time. Data from each trial were combined via a random-effects model for calculation of pooled relative risk (RR) or weighted mean difference (WMD) with a 95% confidence interval (CI). We also performed trial sequential analysis. RESULTS: We included eight trials comprising 571 patients for review. Compared with the GlideScope, Airtraq did not improve success rate, glottic visualization, or intubation time in tracheal intubation (success rate: RR, 0.98; 95% CI, 0.91 to 1.05; P = 0.58; I2 = 65%; glottic visualization: RR, 1.07; 95% CI, 0.88 to 1.29; P = 0.69; I2 = 64%; and intubation time: WMD, 1.4 seconds ; 95% CI, -6.2 to 9.1; P = 0.72; I2 = 96%). The quality of evidence was graded as "very low." Trial sequential analysis showed that total sample size did not reach the required information size for all parameters. CONCLUSION: In this meta-analysis, use of the Airtraq indirect laryngoscope did not result in improved success rate, glottic visualization, or intubation time in tracheal intubation compared with the GlideScope. Trial sequential analysis suggests that further studies are necessary to confirm these findings.
脊髄小脳失調症1型患者の下顎骨観血的整復固定術に対する全身麻酔経験

武田桜, 井上菫, 水田健太郎

日本歯科麻酔学会雑誌　50　(2)　85-87　2022/04
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
歯科医院における院内救急体制の整備状況に関する全国実態調査

藤澤俊明, 水田健太郎, 望月亮, 松村朋香, 立浪康晴, 杉村光隆, 日本歯科麻酔学会「歯科医院で常備すべき救急薬・機器等についての提言」策定プロジェクトチーム

日本歯科麻酔学会雑誌　50　(2)　52-65　2022/04
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
General Anesthetic Management of a Patient With Kleine-Levin Syndrome. International-journal

Masatoshi Fujita, Kentaro Mizuta

Anesthesia progress　69　(1)　39-41　2022/04/01

DOI： 10.2344/anpr-68-03-11 　

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Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by periodic hypersomnia and behavioral or cognitive disturbances. Although prolonged emergence from general anesthesia and postoperative hypersomnia may occur in a patient with KLS, there is little information about the safe anesthetic management of these patients. We describe the case of a 22-year-old female previously diagnosed with KLS who was scheduled to have her third molars extracted under general anesthesia. Because the patient had symptoms of periodic hypersomnia and hyperphagia, the surgery was scheduled during a KLS crisis interval. General anesthesia was induced with propofol, remifentanil, and rocuronium, and maintained with desflurane and remifentanil. To prevent overuse of anesthetic agents, an electroencephalogram (EEG)-based depth of anesthesia monitor (SedLine; Masimo Corporation) was used intraoperatively. A neuromuscular monitor was also used to carefully titrate use of a neuromuscular blocking agent. After surgery, sugammadex was administered, and the patient quickly emerged within 10 minutes, as also confirmed by the EEG monitor. She had no KLS recurrence postoperatively. When anesthetizing patients with KLS, an EEG-based depth of anesthesia monitor and neuromuscular monitor may be warranted to ensure complete emergence from general anesthesia. In addition, elective surgery should be planned during crises intervals.
Melatonin MT2 receptor is expressed and potentiates contraction in human airway smooth muscle. International-journal

Haruka Sasaki, Yi Zhang, Charles W Emala, Kentaro Mizuta

American journal of physiology. Lung cellular and molecular physiology　321　(6)　L991-L1005　2021/10/06

DOI： 10.1152/ajplung.00273.2021 　

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Nocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor which couples to both Gq and Gi proteins, and the MT2 receptor which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle, whether they regulate intracellular cyclic AMP (cAMP) and calcium concentrations ([Ca2+]i) which modulate airway smooth muscle tone, and whether they promote airway smooth muscle cell proliferation. We detected the mRNA and protein expression of the melatonin MT2 but not the MT1 receptor in native human and guinea pig airway smooth muscle and cultured human airway smooth muscle (HASM) cells by RT-PCR, immunoblotting, and immunohistochemistry. Activation of melatonin MT2 receptors with either pharmacological concentrations of melatonin (10 - 100 µM) or the non-selective MT1/MT2 agonist ramelteon (10 µM) significantly inhibited forskolin-stimulated cAMP accumulation in HASM cells, which was reversed by the Gαi protein inhibitor pertussis toxin or knockdown of the MT2 receptor by its specific siRNA. Although melatonin by itself did not induce an initial [Ca2+]i increase and airway contraction, melatonin significantly potentiated acetylcholine-stimulated [Ca2+]i increases, stress fiber formation through the MT2 receptor in HASM cells, and attenuated the relaxant effect of isoproterenol in guinea pig trachea. These findings suggest that the melatonin MT2 receptor is expressed in ASM, and modulates airway smooth muscle tone via reduced cAMP production and increased [Ca2+]i.
Anesthetic Management of a Patient With Ring 18 Syndrome. International-journal

Midori Maekawa, Makoto Yasuda, Haruka Sasaki, Yasuharu Tachinami, Kentaro Mizuta

Anesthesia progress　68　(3)　178-179　2021/10/01

DOI： 10.2344/anpr-68-03-01 　

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Ring 18 syndrome or ring chromosome 18 is an extremely rare genetic disorder involving the fusion of the 18th chromosomal ends to form a ring, often with genetic material loss of varying degrees. Although clinical presentation can be extremely variable, characteristic features usually include craniofacial malformations, delayed development, hypotonia, and other skeletal and congenital heart defects. We report the management of a 20-year-old male with ring chromosome 18 who underwent general anesthesia for dental treatment. Clinical manifestations for this patient included intellectual disability, short stature, hypertelorism, flat nasal bridge, micrognathia, a "carp-shaped" mouth, and aortic and pulmonary valve regurgitation. Although mask ventilation and oral intubation were easily performed, nasal intubation was difficult because of rhinostenosis. When providing general anesthesia for a patient with ring chromosome 18, anesthesiologists should evaluate the patient preoperatively for congenital heart defects and prepare for a potential difficult airway.
Patient satisfaction with deep versus light/moderate sedation for non-surgical procedures: A systematic review and meta-analysis. International-journal

Hiroshi Hoshijima, Hitoshi Higuchi, Aiji Sato Boku, Makiko Shibuya, Yoshinari Morimoto, Toshiaki Fujisawa, Kentaro Mizuta

Medicine　100　(36)　e27176　2021/09/10

DOI： 10.1097/MD.0000000000027176 　

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BACKGROUND: Deep sedation relieves a patient's anxiety and stress during the procedure by inducing patient unconsciousness. However, it remains unclear whether deep sedation actually improves patient satisfaction with the procedure. Therefore, we performed a systematic review and meta-analysis to compare the satisfaction of patients undergoing deep sedation with that of those undergoing light/moderate sedation during non-surgical procedures. METHODS: A comprehensive literature search was performed using electronic databases (search until September 2020). The primary outcome was whether patient satisfaction was higher after deep sedation or light/moderate sedation. The secondary outcome was the relative safety of deep sedation compared with light/moderate sedation in terms of oxygen saturation, systolic blood pressure, and heart rate. The tertiary outcomes were the relative procedure and recovery times for deep versus light/moderate sedation.Data from each of the trials were combined, and calculations were made using DerSimonian and Laird random effects models. The pooled effect estimates for patient satisfaction were evaluated using relative risk (RR) with the 95% confidence interval (CI). The pooled effect estimates for continuous data are expressed as weighted mean difference with the 95% CI. We assessed heterogeneity with the Cochrane Q statistic and the I2 statistic. The risk of bias assessment and Grading of Recommendations Assessment, Development and Evaluation approach were used as the quality assessment method. RESULTS: After removing unrelated studies and applying the exclusion criterion, 5 articles satisfied the inclusion criteria. Patient satisfaction was significantly higher in those who received deep sedation compared with light/moderate sedation (relative risk = 1.12; 95% CI, 1.04-1.20; P = .003; Cochrane Q = 25.0; I2 = 76%).There was no significant difference in oxygen saturation, systolic blood pressure, heart rate, and procedure times according to whether the procedures were performed under deep or light/moderate sedation. However, the recovery time was significantly prolonged in patients under deep sedation. CONCLUSIONS: Our meta-analysis suggests that deep sedation resulted in improved patient satisfaction compared with light/moderate sedation. Deep sedation is recommended for patients undergoing procedures because it improves patient satisfaction. However, respiration and circulation should be carefully monitored both intra-operatively and postoperatively.
Asystole Triggered by the Mouth Opening With a Dental Mouth Gag Under General Anesthesia During Pediatric Oral Surgery: Report of a Rare Case. International-journal

Hiroshi Hoshijima, Risa Takeuchi, Kimiharu Kikuchi, Kentaro Mizuta

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons　79　(9)　1862-1865　2021/03/26

DOI： 10.1016/j.joms.2021.03.016 　

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The trigeminovagal reflex manifests as a sudden onset of bradycardia, hypotension, and cardiac arrest in response to the stimulation of the trigeminal nerve. The incidence of trigeminovagal reflex in maxillofacial surgical procedures is approximately 1.6%. We report a case of asystole in a pediatric patient in whom a dental mouth gag triggered the trigeminovagal reflex during oral surgery. The patient was a 5-year-old boy who was scheduled to undergo extraction of maxillary supernumerary teeth. After tracheal intubation, anesthesia was maintained with sevoflurane and remifentanil. At the beginning of the surgery, his mouth was opened with a dental mouth gag, and electrocardigram showed asystole for 20 seconds. Thereafter, his heart rate spontaneously returned to basal value within 60 seconds. Since sufficient mouth opening was required to conduct the surgery, his mouth was opened again with the gag. When the interincisal distance exceeded about 40 mm, his heart rate suddenly decreased, but spontaneously returned to baseline within 60 second. The subsequent anesthetic course was uneventful.
Ringer's acetate solution-induced precipitation of remimazolam. International-journal Peer-reviewed

Haruka Sasaki, Hiroshi Hoshijima, Kentaro Mizuta

British journal of anaesthesia　126　(3)　e87-e89　2021/03

DOI： 10.1016/j.bja.2020.11.021 　
Anesthetic management in MAO-A and MAO-B deficiency: a case report. Peer-reviewed

Hiroshi Hoshijima, Risa Takeuchi, Kimiharu Kikuchi, Kentaro Mizuta

Journal of anesthesia　34　(5)　773-776　2020/10

DOI： 10.1007/s00540-020-02808-5 　

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Monoamine oxidase (MAO) deficiency is an X-linked hereditary disease characterized by spontaneous deletion of MAO-A and/or MAO-B on the X chromosome. Here, we describe the first reported case of a patient with MAO-A and MAO-B deficiency managed under general anesthesia in dental treatment. The patient was aged 11 years old when he was scheduled for dental treatment. He was diagnosed with MAO-A and MAO-B deficiency on genetic testing at 2 years of age. He was not given premedication, and standard monitoring with noninvasive blood pressure monitoring, pulse oximetry, and ECG was instituted. We also preemptively prepared a cardioverter-defibrillator. General anesthesia was induced with propofol 46 mg (2 mg/kg), then rocuronium 10 mg (0.4 mg/kg) and remifentanil 0.30 μg/kg/min were administered via separate infusion pumps. Orotracheal intubation was performed without complications. Anesthesia was maintained uneventfully with a continuous infusion of remifentanil 0.15-0.2 μg/kg/min and propofol 5.0-7.0 mg/kg. Fresh gas flow included oxygen and air. End-tidal CO2 concentration was maintained at around 35 mmHg throughout the procedure. We administered sugammadex 92 mg (4 mg/kg) for reversal of neuromuscular blockade and the patient was extubated. We achieved successful anesthetic management without any appreciable clinical signs of fatal arrhythmias in this patient with MAO-A and MAO-B deficiency.
Comparison of Hemodynamic Responses to Administration of Vasopressin and Norepinephrine Under General Anesthesia: A Systematic Review and Meta-analysis of Randomized Controlled Trials with Trial Sequential Analysis. International-journal Peer-reviewed

Hiroshi Hoshijima, Takahiro Mihara, Yohei Denawa, Toshiya Shiga, Kentaro Mizuta

Journal of cardiothoracic and vascular anesthesia　35　(1)　61-69　2020/08/11

DOI： 10.1053/j.jvca.2020.08.011 　

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OBJECTIVE: The authors performed a meta-analysis to determine if vasopressin improves hypotension more than norepinephrine under general anesthesia. DESIGN: Meta-analysis. SETTING: Operating room. PATIENTS: Patients who underwent surgery, with general anesthesia. INTERVENTIONS: Administration of vasopressin or norepinephrine in order to increase blood pressure. MEASUREMENTS AND MAIN RESULTS: The primary outcome of this study was to determine if vasopressin increased mean blood pressure more effectively compared with norepinephrine for patients under general anesthesia. The secondary outcome was to see if vasopressin increased heart rate (HR), central venous pressure (CVP), cardiac output (CO), and cardiac index (CI) more significantly compared with norepinephrine under general anesthesia. The authors calculated the weighted mean difference, with 95% confidence interval (CI) using the random-effects model, and calculated the required information size (RIS) by performing trial sequential analysis (TSA). The authors selected 6 studies for analysis. Vasopressin did not improve hypotension compared with norepinephrine under general anesthesia. (weighted mean difference = -0.84 mmHg, 95% CI: -5.90 to 4.23, p = 0.75, Cochran Q = 24.6, I2 = 84%) In TSA, only 35.5% of RIS was achieved. Similarly, vasopressin and norepinephrine were not significantly different in terms of HR, CVP, CO, and CI. In TSA, only 23.7% of the RIS was reached for HR but RIS was almost achieved for CVP and CO. CONCLUSIONS: Vasopressin did not improve hypotension compared with norepinephrine under general anesthesia. The RIS was not reached in TSA, and Grading of Recommendations Assessment, Development and Evaluation is very low. Therefore, further research is needed to reach more robust conclusions.
環状18番染色体症候群患者の歯科治療に対する全身麻酔経験 Peer-reviewed

前川翠, 安田真, 佐々木晴香, 立浪康晴, 水田健太郎

日本歯科麻酔学会雑誌　48　(3)　117-119　2020/07
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管支喘息の受容体機構

水田健太郎

東北大学歯学雑誌　37/38/39　(2/1-2/1)　53-53　2020/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
The short-chain free fatty acid receptor FFAR3 is expressed and potentiates contraction in human airway smooth muscle. International-journal Peer-reviewed

Kentaro Mizuta, Haruka Sasaki, Yi Zhang, Atsuko Matoba, Charles W Emala Sr

American journal of physiology. Lung cellular and molecular physiology　318　(6)　L1248-L1260　2020/06/01

DOI： 10.1152/ajplung.00357.2019 　

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Emerging evidence suggests that gut microbiota-derived short-chain fatty acids (SCFAs; acetate, propionate, and butyrate) are important modulators of the inflammatory state in diseases such as asthma. However, the functional expression of the Gi protein-coupled free fatty acid receptors (FFAR2/GPR43 and FFAR3/GPR41) has not been identified on airway smooth muscle (ASM). Classically, acute activation of Gi-coupled receptors inhibits cyclic AMP (cAMP) synthesis, which impairs ASM relaxation and can also induce crosstalk between Gi- and Gq-signaling pathways, potentiating increases in intracellular Ca2+ concentration ([Ca2+]i), favoring ASM contraction. In contrast, chronic activation of Gi-coupled receptors can sensitize adenylyl cyclase resulting in increased cAMP synthesis favoring relaxation. We questioned whether the Gi-coupled FFAR2 or FFAR3 is expressed in human ASM, whether they modulate cAMP and [Ca2+]i, and whether SCFAs modulate human ASM tone. We detected the protein expression of FFAR3 but not FFAR2 in native human ASM and primary cultured human airway smooth muscle (HASM) cells. In HASM cells, acute activation of FFAR3 with SCFAs inhibited forskolin-stimulated cAMP accumulation, but chronic activation did not sensitize cAMP synthesis. SCFAs induced [Ca2+]i increases that were attenuated by pertussis toxin, gallein, U73122, or xestospongin C. Acute treatment with SCFAs potentiated acetylcholine-stimulated [Ca2+]i increases and stress fiber formation in cells and contraction of ex vivo human airway tissues. In contrast, chronic pretreatment of human ASM with propionate did not potentiate airway relaxation. Together, these findings demonstrate that FFAR3 is expressed in human ASM and contributes to ASM contraction via reduced cAMP and increased [Ca2+]i.
大動脈解離を伴った乾癬性顎関節炎患者の顎関節受動術に対する全身麻酔経験 Peer-reviewed

柴田菫, 安田真, 真藤裕基, 水田健太郎

日本歯科麻酔学会雑誌　48　(1)　10-12　2020/01
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
Obesity-induced asthma: Role of free fatty acid receptors. International-journal Peer-reviewed

Kentaro Mizuta, Atsuko Matoba, Sumire Shibata, Eiji Masaki, Charles W Emala Sr

The Japanese dental science review　55　(1)　103-107　2019/11

DOI： 10.1016/j.jdsr.2019.07.002 　

ISSN： 1882-7616

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Obesity is a major risk factor for the development of asthma, and worsens the key features of asthma including airway hyperresponsiveness, inflammation, and airway remodeling. Although pro- and anti-inflammatory adipocytokines may contribute to the pathogenesis of asthma in obesity, the mechanistic basis for the relationship between asthma and obesity remains unclear. In obese individuals, the increased amount of adipose tissue results in the release of more long-chain free fatty acids as compared to lean individuals, causing an elevation in plasma long-chain free fatty acid concentrations. Recent findings suggest that the free fatty acid receptor 1 (FFAR1), which is a sensor of medium- and long-chain free fatty acids, is expressed on airway smooth muscle and plays a pivotal role in airway contraction and airway smooth muscle cell proliferation. In contrast, FFAR4, which is a sensor for long-chain n-3 polyunsaturated fatty acids and also expressed on airway smooth muscle, does not contribute to airway contraction and airway smooth muscle cell proliferation. Functional roles for short-chain fatty acid receptors FFAR2 and FFAR3 in the pathogenesis of asthma is still under debate. Taken together, adipose-derived long-chain free fatty acids may contribute to the pathogenesis of asthma in obesity through FFAR1.
多発性骨髄腫患者の薬剤関連顎骨壊死に対する腐骨除去術の全身麻酔経験 Peer-reviewed

佐々木晴香, 岡部紗季, 関口香, 前川翠, 水田健太郎

日本歯科麻酔学会雑誌　47　(2)　56-58　2019/04
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
C-MAC videolaryngoscope versus Macintosh laryngoscope for tracheal intubation: A systematic review and meta-analysis with trial sequential analysis. International-journal Peer-reviewed

Hiroshi Hoshijima, Takahiro Mihara, Koichi Maruyama, Yohei Denawa, Kentaro Mizuta, Toshiya Shiga, Hiroshi Nagasaka

Journal of clinical anesthesia　49　53-62　2018/09

DOI： 10.1016/j.jclinane.2018.06.007 　

ISSN： 0952-8180

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STUDY OBJECTIVE: The C-MAC laryngoscope (C-MAC) is a videolaryngoscope that uses a modified Macintosh blade. Although several anecdotal reports exist, it remains unclear whether the C-MAC is superior to the Macintosh laryngoscope for tracheal intubation in the adult population. DESIGN: Systematic review, meta-analysis. SETTING: Operating room, intensive care unit. MEASUREMENTS: For inclusion in our analysis, studies had to be prospective randomised trials which compared the C-MAC with the Macintosh laryngoscope for tracheal intubation in the adult population. Data on success rates, intubation time, glottic visualisation and incidence of external laryngeal manipulations (ELM) during tracheal intubation were extracted from the identified studies. In subgroup analysis, we separated those parameters to assess the influence of the airway condition (normal or difficult) and laryngoscopists (novice or experienced). We conducted a trial sequential analysis (TSA). MAIN RESULTS: Sixteen articles with 18 trials met the inclusion criteria. The C-MAC provided better glottic visualisation compared to the Macintosh (RR, 1.08; 95% CI, 1.03-1.14). TSA corrected the CI to 1.01-1.19; thus, total sample size reached the required information size (RIS). Success rates and intubation time did not differ significantly between the laryngoscopes. TSA showed that total sample size reached the RIS for success rates. The TSA Z curve surpassed the futility boundary. The C-MAC required less ELM compared to the Macintosh (RR, 0.83; 95% CI, 0.72-0.96). TSA corrected the CI to 0.67-1.03; 52.3% of the RIS was achieved. In difficult airways, the C-MAC showed superior success rates, glottic visualisation, and less ELM compared to the Macintosh. Among experienced laryngoscopists, the C-MAC offered better glottic visualisation with less ELM than the Macintosh. CONCLUSIONS: The C-MAC provided better glottic visualisation and less ELM (GRADE: Very Low or Moderate), with improved success rates, glottic visualisation, and less ELM in difficult airways.
The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. International-journal Peer-reviewed

Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-Aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W Emala, Kentaro Mizuta

Respiratory research　19　(1)　53-53　2018/04/02
Publisher: BioMed Central Ltd.
DOI： 10.1186/s12931-018-0757-4 　

ISSN： 1465-993X 1465-9921
The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways. International-journal Peer-reviewed

Atsuko Matoba, Nao Matsuyama, Sumire Shibata, Eiji Masaki, Charles W Emala Sr, Kentaro Mizuta

American journal of physiology. Lung cellular and molecular physiology　314　(3)　L333-L348-L348　2018/03/01
Publisher: American Physiological Society
DOI： 10.1152/ajplung.00129.2017 　

ISSN： 1522-1504 1040-0605
「細菌とアレルギーの新しい考え方(ブドウ球菌、腸内細菌叢を含む)」に寄せる腸内細菌叢と気管支喘息短鎖脂肪酸受容体の役割 Peer-reviewed

水田健太郎

アレルギーの臨床　37　(12)　1180-1183　2017/11
Publisher: (株)北隆館
ISSN： 0285-6379
気管支痙攣と麻酔受容体と細胞内シグナリングを中心に Peer-reviewed

水田健太郎

日本歯科麻酔学会雑誌　45　(5)　639-645　2017/10
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
Weekend versus weekday admission and short-term mortality: A meta-analysis of 88 cohort studies including 56,934,649 participants. International-journal Peer-reviewed

Hiroshi Hoshijima, Risa Takeuchi, Takahiro Mihara, Norifumi Kuratani, Kentaro Mizuta, Zen'ichiro Wajima, Eiji Masaki, Toshiya Shiga

Medicine　96　(17)　e6685　2017/04

DOI： 10.1097/MD.0000000000006685 　

ISSN： 0025-7974

eISSN： 1536-5964
慢性炎症性脱髄性多発神経炎患者の智歯抜歯における全身麻酔経験 Peer-reviewed

藤田雅俊, 水田健太郎, 正木英二

日本歯科麻酔学会雑誌　45　(2)　217-219　2017/04
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
Anesthetic management for a third molar extraction in a patient with chronic inflammatory demyelinating polyneuropathy

Masatoshi Fujita, Kentaro Mizuta, Eiji Masaki

Journal of Japanese Dental Society of Anesthesiology　45　(2)　217-219　2017
Publisher: Japanese Dental Society of Anesthesiology
ISSN： 0386-5835
開口障害を伴う脊髄性筋萎縮症III型患者の全身麻酔経験 Peer-reviewed

山本奈央, 水田健太郎, 正木英二

日本歯科麻酔学会雑誌　44　(2)　183-185　2016/04
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
大学病院障害者歯科治療部における全身麻酔下歯科治療の推移歯学部附属病院における設立から特定機能病院への統合まで Peer-reviewed

高橋温, 伊藤あゆみ, 齊藤峻, 後藤申江, 橋本恵, 石田直子, 長沼由泰, 水田健太郎, 城戸幹太, 佐々木啓一, 猪狩和子

障害者歯科　37　(1)　66-73　2016/02
Publisher: (一社)日本障害者歯科学会
DOI： 10.14958/jjsdh.37.66 　

ISSN： 0913-1663

eISSN： 2188-9708
Anesthetic management of a patient with spinal muscular atrophy type III associated with trismus

Nao Yamamoto, Kentaro Mizuta, Eiji Masaki

Journal of Japanese Dental Society of Anesthesiology　44　(2)　183-185　2016
Publisher: Japanese Dental Society of Anesthesiology
ISSN： 0386-5835
Early Postoperative Nociceptive Threshold and Production of Brain-Derived Neurotrophic Factor Induced by Plantar Incision Are Not Influenced with Minocycline in a Rat: Role of Spinal Microglia. International-journal Peer-reviewed

Eiji Masaki, Kentaro Mizuta, Norimasa Ohtani, Kanta Kido

Neuro-Signals　24　(1)　15-24　2016
Publisher: S. Karger AG
DOI： 10.1159/000442608 　

ISSN： 1424-8638 1424-862X
Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. International-journal Peer-reviewed

Kentaro Mizuta, Yi Zhang, Fumiko Mizuta, Hiroshi Hoshijima, Toshiya Shiga, Eiji Masaki, Charles W Emala Sr

American journal of physiology. Lung cellular and molecular physiology　309　(9)　L970-82-L982　2015/11/01

DOI： 10.1152/ajplung.00041.2015 　

ISSN： 1040-0605

eISSN： 1522-1504
遊離脂肪酸受容体を介した気管支喘息誘発機構 Peer-reviewed

水田健太郎

BIO Clinica　30　(9)　893-896　2015/08
Publisher: (株)北隆館
ISSN： 0919-8237
The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. International-journal Peer-reviewed

Kentaro Mizuta, Yi Zhang, Dingbang Xu, Fumiko Mizuta, Frank D'Ovidio, Eiji Masaki, Charles W Emala

Respiratory research　14　(1)　89-89　2013/09/02

DOI： 10.1186/1465-9921-14-89 　

ISSN： 1465-9921 1465-993X
The dopamine D-1 receptor is expressed and facilitates relaxation in airway smooth muscle Peer-reviewed

Kentaro Mizuta, Yi Zhang, Dingbang Xu, Fumiko Mizuta, Frank D'Ovidio, Eiji Masaki, Charles W. Emala

RESPIRATORY RESEARCH　14　2013/09

DOI： 10.1186/1465-9921-14-89 　

ISSN： 1465-993X

eISSN： 1465-9921
全身麻酔下歯科治療後に代理ミュンヒハウゼン症候群を強く疑うにいたった1例

渡辺泰輔, 水田, 健太郎, 猪狩, 俊郎, 門馬, 祐子, 的場, あつ子, 正木英二

日本歯科麻酔学会雑誌　40　(2)　227-228　2012/04
Publisher:
ISSN： 0386-5835

eISSN： 2433-4480
Role of medullary GABA signal transduction on parasympathetic reflex vasodilatation in the lower lip. International-journal Peer-reviewed

So Kawakami, Hiroshi Izumi, Eiji Masaki, Satoshi Kuchiiwa, Kentaro Mizuta

Brain research　1437　26-37　2012/02/09

DOI： 10.1016/j.brainres.2011.12.023 　

ISSN： 0006-8993
The dopamine D(2) receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle. International-journal Peer-reviewed

Kentaro Mizuta, Yi Zhang, Dingbang Xu, Eiji Masaki, Reynold A Panettieri Jr, Charles W Emala

American journal of physiology. Lung cellular and molecular physiology　302　(3)　L316-24-L324　2012/02/01

DOI： 10.1152/ajplung.00130.2011 　

ISSN： 1040-0605
Regulation of airway responsiveness by dopamine receptor signaling pathways Peer-reviewed

Kentaro Mizuta

Interface Oral Health Science 2011　359-361　2012/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_104 　
Anterior hypothalamic inhibition of reflex parasympathetic vasodilatation in the lower lip and palate of anaesthetized cats Peer-reviewed

Izumi Hiroshi, Ishii Hisayoshi Mizuta Kentaro

北海道医療大学歯学雑誌　30　(2)　161-170　2011/12
Publisher:
ISSN： 1880-5892
Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle. International-journal Peer-reviewed

Kentaro Mizuta, Fumiko Mizuta, Dingbang Xu, Eiji Masaki, Reynold A Panettieri Jr, Charles W Emala

American journal of respiratory cell and molecular biology　45　(6)　1232-8　2011/12

DOI： 10.1165/rcmb.2011-0088OC 　

ISSN： 1044-1549

eISSN： 1535-4989
重度肝硬変・慢性腎不全合併患者の舌部分切除術に対しレミフェンタニル、ミダゾラム併用静脈内鎮静法を用いた麻酔管理の1例

栗原淳, 水田, 健太郎, 宮下, 仁, 正木英二

日本歯科麻酔学会雑誌　39　(2)　194-195　2011/04
Publisher:
ISSN： 0386-5835

eISSN： 2433-4480
Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation. International-journal Peer-reviewed

George Gallos, Neil R Gleason, Laszlo Virag, Yi Zhang, Kentaro Mizuta, Robert A Whittington, Charles W Emala

Anesthesiology　110　(4)　748-58　2009/04

DOI： 10.1097/ALN.0b013e31819c44e1 　

ISSN： 0003-3022

eISSN： 1528-1175
Functional expression of GABAB receptors in airway epithelium. International-journal Peer-reviewed

Kentaro Mizuta, Yoko Osawa, Fumiko Mizuta, Dingbang Xu, Charles W Emala

American journal of respiratory cell and molecular biology　39　(3)　296-304　2008/09

DOI： 10.1165/rcmb.2007-0414OC 　

ISSN： 1044-1549
GABAA receptors are expressed and facilitate relaxation in airway smooth muscle. International-journal Peer-reviewed

Kentaro Mizuta, Dingbang Xu, Yaping Pan, George Comas, Joshua R Sonett, Yi Zhang, Reynold A Panettieri Jr, Jay Yang, Charles W Emala Sr

American journal of physiology. Lung cellular and molecular physiology　294　(6)　L1206-16-L1216　2008/06

DOI： 10.1152/ajplung.00287.2007 　

ISSN： 1040-0605
Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. International-journal Peer-reviewed

Kentaro Mizuta, George Gallos, Defen Zhu, Fumiko Mizuta, Farida Goubaeva, Dingbang Xu, Reynold A Panettieri Jr, Jay Yang, Charles W Emala Sr

American journal of physiology. Lung cellular and molecular physiology　294　(3)　L523-34-L534　2008/03

DOI： 10.1152/ajplung.00328.2007 　

ISSN： 1040-0605
Effects of isoflurane on parasympathetic vasodilatation in the rat submandibular gland Peer-reviewed

K Mizuta, F Mizuta, M Takahashi, H Ishii, T Niioka, H Izumi

JOURNAL OF DENTAL RESEARCH　85　(4)　379-383　2006/04

DOI： 10.1177/154405910608500419 　

ISSN： 0022-0345
Coronary vasospasm during the reversal of neuromuscular block using neostigmine Peer-reviewed

K Kido, K Mizuta, F Mizuta, M Yasuda, T Igari, M Takahashi

ACTA ANAESTHESIOLOGICA SCANDINAVICA　49　(9)　1395-1396　2005/10

DOI： 10.1111/j.1399-6576.2005.00832 　

ISSN： 0001-5172
着衣や腕まくりがオシロメトリック式血圧計の測定値に与える影響

水田文子, 猪狩, 俊郎, 安田, 真, 水田, 健太郎, 城戸, 幹太, 下田, 元, 佐藤, 実, 高橋雅彦

東北大学歯学雑誌　24　(1)　24-30　2005/06
Publisher:
ISSN： 0287-3915
五苓散投与は三叉神経痛患者のカルバマゼピンの服薬量を低減できるか?

安田真, 猪狩, 俊郎, 城戸, 幹太, 水田, 文子, 水田, 健太郎, 岩月, 宏文, 佐藤, 実, 下田, 元, 高橋雅彦

日本歯科麻酔学会雑誌　33　(2)　281-282　2005/04
Publisher:
ISSN： 0386-5835

eISSN： 2433-4480
Bickerstaff型脳幹脳炎患者の全身麻酔経験

水田健太郎, 佐藤, 実高橋雅彦

日本歯科麻酔学会雑誌　33　(1)　108-109　2005/01
Publisher:
ISSN： 0386-5835

eISSN： 2433-4480
Bulbar Pathway for Parasympathetic Reflex Vasodilatation in Orofacial Area Peer-reviewed

Kentaro Mizuta

journal of oral biosciences　47　(3)　221-229　2005

DOI： 10.2330/joralbiosci.47.221 　

ISSN： 1349-0079
Bulbar pathway for contralateral lingual nerve-evoked reflex vasodilatation in cat palate. International-journal Peer-reviewed

Kentaro Mizuta, Hiroshi Izumi

Brain research　1020　(1-2)　86-94　2004/09/10

DOI： 10.1016/j.brainres.2004.06.010 　

ISSN： 0006-8993
Reduction in parasympathetic reflex vasodilatation following stereotaxic ear-bar insertion: importance of reduced afferent input. International-journal Peer-reviewed

Hiroshi Izumi, Hisashi Date, Kentaro Mizuta, Ikuko Nakamura, Satoshi Kuchiiwa

Brain research　961　(1)　53-62　2003/01/24

DOI： 10.1016/S0006-8993(02)03839-8 　

ISSN： 0006-8993
Simultaneous measurement of parasympathetic reflex vasodilator and arterial blood pressure responses in the cat. International-journal Peer-reviewed

Hiroshi Izumi, Kentaro Mizuta, Satoshi Kuchiiwa

Brain research　952　(1)　61-70　2002/10/11

DOI： 10.1016/S0006-8993(02)03196-7 　

ISSN： 0006-8993
Involvement of trigeminal spinal nucleus in parasympathetic reflex vasodilatation in cat lower lip. International-journal Peer-reviewed

Kentaro Mizuta, Satoshi Kuchiiwa, Takashi Saito, Hideaki Mayanagi, Keishiro Karita, Hiroshi Izumi

American journal of physiology. Regulatory, integrative and comparative physiology　282　(2)　R492-500-R500　2002/02

ISSN： 0363-6119
Parasympathetic reflex vasodilatation in rat submandibular gland Peer-reviewed

K Mizuta, K Karita, H Izumi

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY　279　(2)　R677-R683　2000/08

ISSN： 0363-6119

Show all ︎Show first 5

Misc. 76

人工知能を応用した術後悪心嘔吐のリスク因子の同定

星島宏, 水田健太郎

日本歯科麻酔学会雑誌　50　(抄録号)　126-126　2022/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
SAPHO症候群患者に対する全身麻酔経験

武田桜, 星島宏, 水田健太郎

日本歯科麻酔学会雑誌　50　(抄録号)　186-186　2022/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
夜間喘息の病態におけるメラトニン受容体の役割

佐々木晴香, 水田健太郎

東北大学歯学雑誌　39/40/41　(2/1-2/1)　48-48　2022/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
東北大学病院口腔内科・リエゾンセンターにおける初診患者の動向

庄司憲明, 千葉雅俊, 永井宏和, 佐藤しづ子, 菅原由美子, 小川徹, 重光竜二, 岩間亮介, 鈴木飛佳理, 工藤葉子, 安田真, 水田健太郎, 田中恭恵, 山口哲史, 八幡祥生, 五十嵐薫

東北大学歯学雑誌　39/40/41　(2/1-2/1)　52-53　2022/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
気管平滑筋におけるメラトニン受容体MT2の発現と細胞内シグナリング機構(Expression and coupling of melatonin MT2 receptor to cyclic AMP and calcium signaling pathways in human airway smooth muscle)

佐々木晴香, 水田健太郎

Journal of Oral Biosciences Supplement　2021　172-172　2021/10
Publisher: (一社)歯科基礎医学会
ISSN： 2187-2333

eISSN： 2187-9109
小児鎮静の適応とリスク小児歯科治療の鎮静(小児鎮静の適応とリスク)

星島宏, 水田健太郎

日本小児麻酔学会大会プログラム　26回　7-7　2021/10
Publisher: (一社)日本小児麻酔学会
メラトニンMT2受容体を介した気管平滑筋収縮機構

佐々木晴香, 水田健太郎

日本歯科麻酔学会雑誌　49　(抄録号)　108-108　2021/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
若年発症成人型糖尿病(MODY3)患者の顎矯正手術に対する全身麻酔管理経験

工藤葉子, 星島宏, 石川実花, 水田健太郎

日本歯科麻酔学会雑誌　49　(抄録号)　137-137　2021/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
生体情報モニタリングとCrew Resource Management

水田健太郎

日本歯科麻酔学会雑誌　48　(抄録号)　103-103　2020/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
ヒスチジン脱炭酸酵素レポーターマウスを用いた新規ヒスタミン産生細胞の同定

田中志典, 水田健太郎

日本歯科麻酔学会雑誌　48　(抄録号)　119-119　2020/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
挿管困難患者におけるMcGrathビデオ喉頭鏡とMacintosh型喉頭鏡の気管挿管時の比較 meta-analysis

星島宏, 竹内梨紗, 菊地公治, 水田健太郎

日本歯科麻酔学会雑誌　48　(抄録号)　124-124　2020/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
歯科麻酔学臨床実習における双方向性オンライン教育プログラムの導入

工藤葉子, 田中志典, 星島宏, 佐々木詩織, 佐々木晴香, 関口香, 柴田菫, 真藤裕基, 高山紘子, 安田真, 水田健太郎

日本歯科麻酔学会雑誌　48　(抄録号)　142-142　2020/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
Noonan症候群患者の上下顎骨骨切り術に対する全身麻酔経験

佐々木晴香, 高山紘子, 水田健太郎

日本歯科麻酔学会雑誌　48　(抄録号)　155-155　2020/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
Kleine-Levin症候群の全身麻酔経験

藤田雅俊, 水田健太郎

日本歯科麻酔学会雑誌　48　(抄録号)　160-160　2020/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管支喘息の受容体機構

水田健太郎

東北大学歯学雑誌　37/38/39　(2/1-2/1)　53-53　2020/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
古典型Ehlers-Danlos syndrome患者の全身麻酔経験

真藤裕基, 的場あつ子, 柴田菫, 水田健太郎

日本歯科麻酔学会雑誌　47　(抄録号)　216-216　2019/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
未来の歯科麻酔学研究 AIによる自動鎮静システムの開発

岡田明子, 水田健太郎

日本歯科麻酔学会雑誌　47　(抄録号)　136-136　2019/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
歯科麻酔科医と歯科治療若手歯科麻酔科医は麻酔科学の研鑽に注力すべきである

水田健太郎

日本歯科麻酔学会雑誌　47　(抄録号)　143-143　2019/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
短鎖脂肪酸によるヒト気管平滑筋収縮作用の細胞内シグナリング機構

佐々木晴香, 的場あつ子, 水田文子, 水田健太郎

日本歯科麻酔学会雑誌　47　(抄録号)　176-176　2019/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
腎細胞癌の口蓋転移腫瘍切除術に対する全身麻酔経験

佐々木晴香, 的場あつ子, 水田健太郎

日本歯科麻酔学会雑誌　47　(抄録号)　215-215　2019/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
顎変形症治療におけるトラブルシューティング顎変形症治療のトラブルシューティング歯科麻酔科医の立場から

水田健太郎

日本顎変形症学会雑誌　29　(2)　112-112　2019/05
Publisher: (NPO)日本顎変形症学会
ISSN： 0916-7048
短鎖脂肪酸受容体FFAR3を介したヒト気管平滑筋張力制御機構

的場あつ子, 水田文子, 正木英二, 水田健太郎

日本歯科麻酔学会雑誌　45　(4)　530-530　2017/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
歯科治療前の検査を契機に全身疾患が診断された症例について

伊藤あゆみ, 長沼由泰, 松坂久美, 高橋温, 城戸幹太, 水田健太郎, 猪狩和子, 佐々木啓一

障害者歯科　38　(3)　408-408　2017/09
Publisher: (一社)日本障害者歯科学会
ISSN： 0913-1663

eISSN： 2188-9708
歯科麻酔学研究の未来と希望歯科麻酔科学研究の課題と解決策 Wells、Mortonを越えて

水田健太郎

日本歯科麻酔学会雑誌　45　(4)　520-520　2017/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管支痙攣と麻酔受容体と細胞内シグナリングを中心に Peer-reviewed

水田健太郎

日本歯科麻酔学会雑誌　44　(4)　467-468　2016/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管平滑筋における短鎖脂肪酸受容体FFAR3の発現と細胞内シグナリング機構

水田健太郎, 的場あつ子, 松山奈央, 水田文子, 正木英二

日本歯科麻酔学会雑誌　44　(4)　506-506　2016/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
オメガ3脂肪酸受容体FFAR4は気管の収縮・弛緩に関与するか?

堀綾子, 的場あつ子, 正木英二, 水田健太郎

日本歯科麻酔学会雑誌　43　(4)　522-522　2015/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
長鎖遊離脂肪酸受容体FFAR4による気道リモデリング促進作用の細胞内機序

的場あつ子, 山本奈央, 堀綾子, 正木英二, 水田健太郎

日本歯科麻酔学会雑誌　43　(4)　523-523　2015/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
慎重な対策が必要であった軟骨無形成患者の顎矯正手術に対する気道管理

松井有恒, 水田健太郎, 堀綾子, 正木英二

日本歯科麻酔学会雑誌　43　(4)　602-602　2015/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
長鎖遊離脂肪酸受容体FFAR1を介した気管平滑筋細胞増殖作用とその細胞内機序

水田健太郎

Journal of Oral Biosciences Supplement　2015　512-512　2015/09
Publisher: (一社)歯科基礎医学会
ISSN： 2187-2333

eISSN： 2187-9109
遊離脂肪酸受容体FFAR1を介した気道リモデリングの細胞内シグナル伝達機構

的場あつ子, 滝口晃嗣, 正木英二, 水田健太郎

日本歯科麻酔学会雑誌　42　(4)　467-467　2014/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
脊髄性筋萎縮症III型患者の全身麻酔経験

山本奈央, 水田健太郎, 星島宏, 正木英二

日本歯科麻酔学会雑誌　42　(4)　521-521　2014/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
当治療部における全身麻酔下歯科治療症例の背景調査

伊藤あゆみ, 高橋温, 神藤佑亮, 水田健太郎, 城戸幹太, 橋本恵, 石田直子, 長沼由泰, 猪狩和子, 佐々木啓一

障害者歯科　35　(3)　501-501　2014/09
Publisher: (一社)日本障害者歯科学会
ISSN： 0913-1663

eISSN： 2188-9708
チューブガイド付きビデオ硬性挿管用喉頭鏡が有用であった挿管困難の既往を持つラッセル・シルバー症候群の全身麻酔経験

星島宏, 水田健太郎, 高橋温

障害者歯科　35　(3)　511-511　2014/09
Publisher: (一社)日本障害者歯科学会
ISSN： 0913-1663

eISSN： 2188-9708
気管平滑筋における遊離脂肪酸受容体FFAR1の発現と気管収縮促進作用

水田健太郎

日本呼吸器学会誌　3　(増刊)　264-264　2014/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
東北大学病院における全身麻酔下歯科治療チームの設立 Peer-reviewed

水田健太郎, 安田真, 笹崎弘己, 小川徹, 冨士岳志, 橋元亘, 高橋温, 山田亜矢, 正木英二, 五十嵐薫

みちのく歯学会雑誌　44　(1-2)　36-37　2013/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
遊離脂肪酸受容体FFAR1を介した気管平滑筋収縮促進作用

水田健太郎, 水田文子, 正木英二

日本歯科麻酔学会雑誌　41　(4)　536-536　2013/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
遊離脂肪酸は気管平滑筋上の遊離脂肪酸受容体FFAR1を介して気管収縮を促進させる

水田健太郎, 工藤忠明

Journal of Oral Biosciences Supplement　2013　121-121　2013/09
Publisher: (一社)歯科基礎医学会
ISSN： 2187-2333

eISSN： 2187-9109
気管平滑筋における遊離脂肪酸受容体FFAR1の発現と気道リモデリング促進作用

水田健太郎, 後藤阿裕美, 正木英二

日本歯科麻酔学会雑誌　40　(4)　532-532　2012/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管上皮におけるドーパミンD1受容体の発現とMUC5AC遺伝子発現促進作用

後藤阿裕美, 正木英二, 水田健太郎

日本歯科麻酔学会雑誌　40　(4)　532-532　2012/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
当院における「全身麻酔下歯科治療チーム」の取り組み

渡辺泰輔, 水田健太郎, 安田真, 的場あつ子, 城戸幹太, 川上壮, 正木英二

日本歯科麻酔学会雑誌　40　(4)　539-539　2012/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管平滑筋におけるドーパミンD1受容体の発現と気管平滑筋弛緩作用

水田健太郎, 水田文子, 正木英二

日本歯科麻酔学会雑誌　39　(4)　488-488　2011/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
術後出血に対する再手術時の気管挿管に難渋した舌腫瘍患者の麻酔経験

安田真, 後藤阿裕美, 水田健太郎, 的場あつ子, 川上壮, 正木英二

日本歯科麻酔学会雑誌　39　(4)　531-531　2011/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835
GABAB受容体を介した気管平滑筋収縮作用の細胞内シグナリング機構

水田健太郎, 後藤阿裕美, 正木英二

Journal of Oral Biosciences　53　(Suppl.)　122-122　2011/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
ドーパミン受容体による気管支喘息抑制機構

水田健太郎

上原記念生命科学財団研究報告集　24　1-5　2010/12
Publisher: (公財)上原記念生命科学財団
eISSN： 2433-3441
気管平滑筋におけるdopamine D2受容体の発現とアデニル酸シクラーゼ活性の調節

水田健太郎, 水田文子, 正木英二

日本歯科麻酔学会雑誌　38　(4)　462-462　2010/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
多剤に対するアナフィラキシーを頻回に起こした1症例

青井あつ子, 水田健太郎, 正木英二

日本歯科麻酔学会雑誌　38　(4)　492-492　2010/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
口腔領域に生じる体性-副交感神経反射の反射中枢におけるGABA受容体の関与

川上壮, 正木英二, 水田健太郎

日本歯科麻酔学会雑誌　38　(4)　535-535　2010/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
意識下ファイバースコープによる気管挿管に難渋した、巨大下顎エナメル上皮腫の麻酔経験

川上壮, 栗原淳, 青井あつ子, 安田真, 水田健太郎, 正木英二

日本歯科麻酔学会雑誌　38　(4)　540-540　2010/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管平滑筋におけるdopamine D1受容体の発現と気管収縮抑制機構

水田健太郎

Journal of Oral Biosciences　52　(Suppl)　100-100　2010/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
口腔領域における体性-副交感神経反射の反射中枢でのGABAB受容体の関与

川上壮, 和泉博之, 水田健太郎

Journal of Oral Biosciences　52　(Suppl)　130-130　2010/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
顎矯正手術直後の止血に難渋した骨形成不全症患者の全身麻酔管理

青井あつ子, 水田健太郎, 安藤瞳, 猪狩俊郎, 正木英二

日本歯科麻酔学会雑誌　37　(4)　496-496　2009/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管平滑筋のGABAB受容体はIP3合成を促進する

水田健太郎, 水田文子, 正木英二

日本歯科麻酔学会雑誌　37　(4)　510-510　2009/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管上皮におけるGABAB受容体の発現とその機能的役割

水田健太郎, 水田文子, 正木英二

日本歯科麻酔学会雑誌　37　(4)　510-510　2009/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
当治療部における全身麻酔下歯科治療状況の推移

高橋温, 後藤申江, 安藤瞳, 伊藤あゆみ, 齊藤峻, 水田健太郎, 城戸幹太, 猪狩俊郎, 正木英二, 猪狩和子, 佐々木啓一

障害者歯科　30　(3)　483-483　2009/09
Publisher: (一社)日本障害者歯科学会
ISSN： 0913-1663

eISSN： 2188-9708
気管平滑筋におけるDopamine D2受容体の発現と気管収縮抑制機構

水田健太郎

Journal of Oral Biosciences　51　(Suppl.)　79-79　2009/08
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
気管平滑筋におけるDopamine D2受容体の発現と気管収縮抑制機構

水田健太郎

Journal of Oral Biosciences　51　(Suppl.)　106-106　2009/08
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
口腔領域における体性-副交感神経反射の反射中枢におけるGABAA受容体の役割

川上壮, 和泉博之, 水田健太郎

Journal of Oral Biosciences　51　(Suppl.)　107-107　2009/08
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
気管平滑筋におけるGABAA受容体の発現とその気管収縮抑制作用

水田健太郎

Journal of Oral Biosciences　50　(Suppl.)　143-143　2008/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
プロポフォールによる横紋筋融解症が疑われたDown症候群患者の一例

城戸幹太, 青井あつ子, 安田真, 水田健太郎, 猪狩俊郎

日本歯科麻酔学会雑誌　36　(4)　470-470　2008/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管平滑筋におけるGABAA受容体の存在と機能的役割

水田健太郎

日本歯科麻酔学会雑誌　36　(4)　509-509　2008/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
気管平滑筋におけるneurokinin受容体の発現とその細胞内シグナリング機構

水田健太郎, 水田文子

日本歯科麻酔学会雑誌　36　(4)　509-509　2008/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
着衣や腕まくりがオシロメトリック式血圧計の測定値に与える影響

猪狩俊郎, 水田文子, 安田真, 水田健太郎, 城戸幹太, 佐藤実, 高橋雅彦

日本歯科麻酔学会雑誌　33　(4)　585-585　2005/09
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
ネコにおける三叉神経-副交感神経反射性血管拡張反応の中枢機序

水田健太郎

Journal of Oral Biosciences　46　(5)　374-374　2004/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
アルツハイマー型痴呆を有し齲蝕の多発を引き起こした1症例

高橋温, 水田健太郎, 穂積由里子, 小久江由佳子, 齊藤峻, 真柳秀昭

障害者歯科　24　(3)　354-354　2003/09
Publisher: (一社)日本障害者歯科学会
ISSN： 0913-1663

eISSN： 2188-9708
顎矯正手術中の循環管理に苦慮した1例

水田健太郎, 佐藤実, 下田元, 城戸幹太, 安田真, 那須文子, 山口晃司, 今野俊宏, 猪狩俊郎

日本歯科麻酔学会雑誌　31　(4)　436-436　2003/08
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
全身麻酔後に喉頭肉芽腫が認められた1例

那須文子, 佐藤実, 山口晃司, 今野俊宏, 水田健太郎, 安田真, 城戸幹太, 下田元, 猪狩俊郎

日本歯科麻酔学会雑誌　31　(4)　442-442　2003/08
Publisher: (一社)日本歯科麻酔学会
ISSN： 0386-5835

eISSN： 2433-4480
三叉神経刺激時の体性-交感神経反射と体性-副交感神経反射について

和泉博之, 水田健太郎

歯科基礎医学会雑誌　44　(5)　410-410　2002/09
Publisher: (一社)歯科基礎医学会
ISSN： 0385-0137
口唇及び口蓋における体性-副交感神経反射性血管拡張反応の中枢機序の相違

水田健太郎, 和泉博之, 齊藤峻, 真柳秀昭

歯科基礎医学会雑誌　44　(5)　487-487　2002/09
Publisher: (一社)歯科基礎医学会
ISSN： 0385-0137
Familial cleidocranial dysplasiaの1家系

水田健太郎, 猪狩和子, 穂積由里子, 真柳秀昭, 古内壽, 飯久保正弘

小児歯科学雑誌　40　(2)　379-379　2002/04
Publisher: (公社)日本小児歯科学会
ISSN： 0583-1199

eISSN： 2186-5078
三叉神経-副交感神経反射の中枢機序について

和泉博之, 水田健太郎, 小枝総子, 安田真, 桜井康全, 刈田啓史郎

日本生理学雑誌　64　(4)　68-68　2002/04
Publisher: (一社)日本生理学会
ISSN： 0031-9341
Angelman syndrome患児5症例の歯科的所見

水田健太郎, 齊藤峻, 猪狩和子, 穂積由里子, 高橋温, 真柳秀昭

障害者歯科　22　(4)　362-362　2001/11
Publisher: (一社)日本障害者歯科学会
ISSN： 0913-1663

eISSN： 2188-9708
ネコにおける体性-副交感神経反射性血管拡張反応の中枢機序について

水田健太郎, 和泉博之, 齊藤峻, 真柳秀昭, 刈田啓史郎

歯科基礎医学会雑誌　43　(5)　560-560　2001/08
Publisher: (一社)歯科基礎医学会
ISSN： 0385-0137
口唇血管を支配する交感神経血管収縮の役割について

和泉博之, 水田健太郎, 小枝聡子, 刈田啓史郎

日本生理学雑誌　63　(4)　116-116　2001/04
Publisher: (一社)日本生理学会
ISSN： 0031-9341
ラットにおける体性-副交感神経反射の存在について

水田健太郎, 和泉博之, 刈田啓史郎

日本生理学雑誌　62　(1)　49-49　2000/01
Publisher: (一社)日本生理学会
ISSN： 0031-9341
ラットにおける体性-副交感神経反射の存在について

水田健太郎, 和泉博之, 刈田啓史郎, 斉藤峻, 真柳秀昭

歯科基礎医学会雑誌　41　(5)　499-499　1999/08
Publisher: (一社)歯科基礎医学会
ISSN： 0385-0137

Show all ︎Show first 5

Presentations 66

短鎖脂肪酸によるヒト気管平滑筋収縮作用の細胞内シグナリング機構

佐々木晴香, 的場あつ子, 水田文子, 水田健太郎

日本歯科麻酔学会雑誌　2019/09
歯科治療前の検査を契機に全身疾患が診断された症例について

伊藤あゆみ, 長沼由泰, 松坂久美, 高橋温, 城戸幹太, 水田健太郎, 猪狩和子, 佐々木啓一

障害者歯科　2017/09
短鎖脂肪酸受容体FFAR3を介したヒト気管平滑筋張力制御機構

的場あつ子, 水田文子, 正木英二, 水田健太郎

日本歯科麻酔学会雑誌　2017/09
気管平滑筋における短鎖脂肪酸受容体FFAR3の発現と細胞内シグナリング機構

水田健太郎, 的場あつ子, 松山奈央, 水田文子, 正木英二

日本歯科麻酔学会雑誌　2016/09
気管支痙攣と麻酔受容体と細胞内シグナリングを中心に

水田健太郎

日本歯科麻酔学会雑誌　2016/09
東北大学病院における全身麻酔下歯科治療チームの設立

水田健太郎, 安田真, 笹崎弘己, 小川徹, 冨士岳志, 橋元亘, 高橋温, 山田亜矢, 正木英二, 五十嵐薫

第６６回東北地区歯科医学会　2013/10/19
The free fatty acid receptor 1 is expressed and potentiates contraction in airway smooth muscle International-presentation

Mizuta K, Zhang Y, Xu D, Mizuta F, Masaki E, Emala CW

American Society of Anesthesiologists Annual Meeting 2013　2013/10/12
遊離脂肪酸受容体FFAR1を介した気管平滑筋収縮促進機構

水田健太郎, 水田文子, 正木英二

第４１回日本歯科麻酔学会学術集会　2013/10/03
遊離脂肪酸は気管平滑筋上の遊離脂肪酸受容体FFAR1を介して気管収縮を促進させる

水田健太郎, 工藤忠明

第５５回歯科基礎医学会　2013/09/20
東北大学病院における全身麻酔下歯科治療チームの設立と運営

水田健太郎, 安田真, 渡辺泰輔, 笹崎弘己, 小川徹, 冨士岳志, 橋元亘, 高橋温, 山田亜矢, 城戸幹太, 的場あつ子, 星島宏, 小野瞳, 山本奈央, 五十嵐薫, 正木英二

第２８回東日本歯科麻酔学会　2013/06/22
気管平滑筋における遊離脂肪酸受容体FFAR1の発現とその役割

水田健太郎, 水田文子, 堀之内節, 佐藤港, 正木英二, Charles W. Emala

第６０回日本麻酔科学会学術集会　2013/05/23
The Dopamine D1 Receptor is Expressed and Stimulates Cyclic AMP Production in Airway Epithelium

Goto A, Mizuta K, Danielsson J, Mizuta F, Masaki E, Emala CW

American Society of Anesthesiologists Annual Meeting 2012　2012/10/13
気管上皮におけるドーパミンD1受容体の発現とCREB活性化作用の検討

後藤阿裕美, 正木英二, 水田健太郎

第４０回日本歯科麻酔学会学術集会　2012/10/04
気管平滑筋における遊離脂肪酸受容体FFAR1の発現と気道リモデリング促進作用

水田健太郎, 後藤阿裕美, 正木英二

第４０回日本歯科麻酔学会学術集会　2012/10/04
全身麻酔下に歯科治療を行った重症筋無力症患者の１例

渡辺泰輔, 城戸幹太, 水田健太郎, 正木英二

第２７回東日本歯科麻酔学会　2012/07/28
Dopamine D1 receptor-mediated airway smooth muscle relaxation is mediated via a cyclic AMP pathway International-presentation

Kentaro Mizuta, Yi Zhang, Dingbang Xu, Fumiko Mizuta, Eiji Masaki, Charles W. Emala

Euroanaesthesia 2012　2012/06/09
気管上皮におけるドーパミンD1受容体の発現とCFTR活性化作用

後藤阿裕美, Charles W. Emala, 正木英二, 水田健太郎

第５９回日本麻酔科学会学術集会　2012/06/07
気管平滑筋におけるドーパミンＤ１受容体の発現と気管平滑筋弛緩作用

水田健太郎, 水田文子, 正木英二

第３９回日本歯科麻酔学会学術集会　2011/10/08
術後出血に対する再手術時の気管挿管に難渋した舌腫瘍患者の麻酔経験

安田真, 後藤阿裕美, 水田健太郎, 的場あつ子, 川上壮, 正木英二

第３９回日本歯科麻酔学会　2011/10/08
GABAB受容体を介した気管平滑筋収縮作用の細胞内シグナリング機構

水田健太郎, 後藤阿裕美, 正木英二

第５３回歯科基礎医学会　2011/10/01
GABAA受容体を介した気管支痙攣抑制機構の解明

水田健太郎, 正木英二

第２６回東日本歯科麻酔学会　2011/06/04
気管平滑筋におけるDopamine D1受容体の発現と気管支痙攣抑制機構

水田健太郎, 正木英二, YI ZHANG, 堀之内節, 佐藤港, CHARLES EMALA

第５８回日本麻酔科学会　2011/05/18
Functional expression of dopamine receptor in airway smooth muscle International-presentation

Kentaro Mizuta

東北大学-ハーバード大学-Forsyth Institute合同シンポジウム　2011/01/06
Functional expression of the dopamine D1 receptor in airway smooth muscle International-presentation

Kentaro Mizuta, Yi Zhang, Dingbang Xu, Eiji Masaki, Charles W. Emala

アメリカ麻酔学会年次集会　2010/10/16
気管平滑筋におけるDopamine D2受容体の発現とアデニル酸シクラーゼ活性の調節

水田健太郎, 水田文子, 正木英二

第38回日本歯科麻酔学会　2010/10/08
多剤に対するアナフィラキシーを頻回に起こした１症例

的場あつ子, 水田健太郎, 正木英二

第38回日本歯科麻酔学会　2010/10/08
口腔領域に生じる体性−副交感神経反射の反射中枢におけるGABA受容体の関与

川上壮, 正木英二, 水田健太郎

第38回日本歯科麻酔学会　2010/10/08
意識下ファイバースコープによる気管挿管に難渋した，巨大下顎エナメル上皮腫の麻酔経験

川上壮, 栗原淳, 青井あつ子, 安田真, 水田健太郎, 正木英二

第３８回日本歯科麻酔学会　2010/10/08
気管平滑筋におけるDopamine D1受容体の発現と気管収縮抑制機構

水田健太郎

第５２回歯科基礎医学会総会　2010/09/22
口腔領域における体性−副交感神経反射の反射中枢でのGABAB受容体の関与

川上壮, 和泉博之, 水田健太郎

第52回歯科基礎医学会　2010/09/22
多剤アレルギーの既往を有する患者の全身麻酔下歯科治療経験

青井あつ子, 渡辺泰輔, 水田健太郎, 正木英二

第２５回東日本歯科麻酔学会　2010/08/01
気管平滑筋におけるDopamine D2受容体の発現とその機能的役割

水田健太郎, Yi Zhang, Dingbang Xu, 正木英二, Charles W. Emala

第５７回日本麻酔科学会　2010/06/02
当治療部における全身麻酔下歯科治療状況の推移

高橋温, 後藤申江, 安藤瞳, 伊藤あゆみ, 水田健太郎, 城戸幹太, 猪狩俊郎, 正木英二, 猪狩和子, 佐々木啓一

第２６回日本障害者歯科学会学術大会　2009/10/30
Dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle International-presentation

Kentaro Mizuta, Dingbang Xu, Yi Zhang, Charles W. Emala

American Society of Anesthesiologists 2009 Annual meeting　2009/10/17
気管平滑筋のGABAB受容体はIP3合成を促進する

水田健太郎, 水田文子, 正木英二

第３７回日本歯科麻酔学会学術集会　2009/10/08
気管上皮におけるGABAB受容体の発現とその機能的役割

水田健太郎, 水田文子, 正木英二

第３７回日本歯科麻酔学会学術集会　2009/10/08
額矯正手術直後の止血に難渋した骨形成不全症患者の全身麻酔管理

青井あつ子, 水田健太郎, 安藤瞳, 猪狩俊郎, 正木英二

第３７回日本歯科麻酔学会学術集会　2009/10/08
ＧＡＢＡ（Ａ）受容体を介した気管平滑筋収縮抑制機構における細胞内Ｃａシグナリング

水田健太郎, Charles W. Emala, 正木英二

日本麻酔科学会東北地方会　2009/09/12
気管平滑筋におけるDopamine D2受容体の発現と気管収縮抑制機構

水田健太郎

第５１回歯科基礎医学会　2009/09/09
口腔領域における体性-副交感神経反射性血管拡張反応の反射中枢におけるＧＡＢＡ（Ａ）受容体の役割

川上壮, 和泉博之, 水田健太郎

第５１回歯科基礎医学会　2009/09/09
気管平滑筋のGABA(B)受容体はIP3合成を促進する

水田健太郎, 水田文子, 杉山陽子, Charles W. Emala

第５６回日本麻酔科学会　2009/08/16
全身麻酔管理後に代理ミュンヒハウゼン症候群が疑われた一例

水田健太郎, 猪狩俊郎, 正木英二

第２４回日本歯科麻酔学会東北地方会　2009/08/01
重度肝機能障害を伴った患者に対して行った静脈内鎮静法

栗原淳, 水田健太郎, 立花陽子, 猪狩俊郎, 川上壮, 青井あつ子, 城戸幹太, 正木英二

第２４回日本歯科麻酔学会東北地方会　2009/08/01
術中換気不全に陥った無気肺の一症例

川上壮, 正木英二, 立花陽子, 栗原淳, 青井あつ子, 安田真, 水田健太郎, 城戸幹太, 猪狩俊郎

第２４回日本歯科麻酔学会東北地方会　2009/08/01
気管平滑筋におけるＧＡＢＡＡ受容体の存在と機能的役割

水田健太郎

第３６回日本歯科麻酔学会総会　2008/10/08
気管平滑筋におけるneurokinin受容体の発現とその細胞内シグナリング機構

水田健太郎, 水田文子

第３６回日本歯科麻酔学会総会　2008/10/08
プロポフォールによる横紋筋融解症が疑われたDown症候群患者の一例

城戸幹太, 青井あつ子, 安田真, 水田健太郎, 猪狩俊郎

第３６回日本歯科麻酔学会総会　2008/10/08
気管平滑筋におけるGABA(A)受容体の発現とその気管収縮抑制作用

水田健太郎

第５０回歯科基礎医学会総会　2008/09/23
プロポフォールにより誘発された神経調節性失神の1例

水田健太郎, 青井あつ子, 栗原淳, 猪狩俊郎

日本歯科麻酔学会東北地方会　2008/06/28
気管平滑筋におけるＧＡＢＡＡ受容体の存在とその機能的役割

水田健太郎, 高橋雅彦, Dingbang Xu, Yi Zhang, Charles W Emala

日本麻酔科学会　2008/06/12
GABA A Receptors Inhibit Increases in Intracellular Calcium in Human Airway Smooth Muscle Cells International-presentation

Kentaro Mizuta, Jay Yang, Yi Zhang, Charles W. Emala

American Society of Anesthesiologists 2007 Annual Meeting　2007/10/13
GABA B Receptors Potentiate Inositol Phosphate Synthesis in Airway Smooth Muscle International-presentation

Kentaro Mizuta, Fumiko Mizuta, Charles W. Emala

American Society of Anesthesiologists 2007 Annual meeting　2007/10/13
Coupling of Tachykinin Receptors to Kinase and Calcium Pathways in Human Airway Smooth Muscle Cells International-presentation

Kentaro Mizuta, Fumiko Mizuta, Jay Yang, Charles W. Emala

American Society of Anesthesiologists 2007 Annual meeting　2007/10/13
Functional Expression of GABA B Receptors in Airway Epithelium International-presentation

Kentaro Mizuta, Yoko Osawa, Fumiko Mizuta, Charles W. Emala

American Society of Anesthesiologists 2007 Annual meeting　2007/10/13
Functional Expression of GABAB Receptors in Airway Smooth Muscle International-presentation

Yoko Osawa, Dingbang Xu, Kentaro Mizuta, Charles W. Emala

American Society of Anesthesiologists 2006 Annual meeting　2006/10/14
GABA A Receptors Are Expressed and Facilitate Relaxation in Airway Smooth Muscle International-presentation

Kentaro Mizuta, Yoko Osawa, Dingbang Xu, Yi Zhang, Charles W. Emala

American Society of Anesthesiologists 2006 Annual meeting　2006/10/14
抜管直後に著しい後出血をきたした顎矯正手術の１症例

水田健太郎, 佐藤実, 猪狩俊郎, 下田元, 城戸幹太, 水田文子, 安田真, 高橋雅彦

第２０回日本歯科麻酔学会東北地方会　2005/07/27
Bulbar Pathway for Contralateral Lingual Nerve-evoked Reflex Vasodilatation in Palate International-presentation

Mizuta K, Izumi H

83rd General Session & Exhibition of the IADR　2005/03/09
ネコにおける三叉神経-副交感神経反射性血管拡張反応の中枢機序

水田健太郎

第４６回歯科基礎医学会総会　2004/09/23
Bickerstaff型脳幹脳炎患者の全身麻酔経験

水田健太郎, 佐藤実, 下田元, 城戸幹太, 安田真, 増田愛, 水田文子, 猪狩俊郎, 高橋雅彦

第１９回日本歯科麻酔学会東北地方会　2004/07/27
顎矯正手術中の循環管理に苦慮した１例

水田健太郎, 佐藤実, 下田元, 城戸幹太, 安田真, 那須文子, 山口晃史, 今野俊宏, 猪狩俊郎

日本歯科麻酔学会総会　2003/10/20
口唇及び口蓋における体性-副交感神経反射性血管拡張反応の中枢機序の相違

水田健太郎, 和泉博之, 齊藤峻, 真柳秀昭

第４４回歯科基礎医学会総会　2002/10/27
Familial cleidocranial dysplasia の１家系

水田健太郎, 猪狩和子, 穂積由里子, 真柳秀昭, 古内壽, 飯久保正弘

第４０回日本小児歯科学会総会　2002/05/31
Angelman syndrome患児5症例の歯科学的所見

水田健太郎, 齊藤峻, 猪狩和子, 穂積由里子, 高橋温, 真柳秀昭

第１９回日本障害者歯科学会総会　2001/12/10
ネコにおける体性-副交感神経反射性血管拡張反応の中枢機序について

水田健太郎, 和泉博之, 斉藤峻, 真柳秀昭, 刈田啓史郎

第４３回歯科基礎医学会総会　2001/09/27
ラットにおける体性-副交感神経反射の存在について

水田健太郎, 和泉博之, 刈田啓史郎, 斉藤峻, 真柳秀昭

第４１回歯科基礎医学会総会　1999/09/27

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Research Projects 23

老化による神経障害性疼痛増悪機構の解明とミトコンドリア標的治療

水田健太郎, 小山内実, 阿部高明, 篠田雅路, 佐々木晴香

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2024/04/01 - 2028/03/31
Novel molecular mechanism of oral cancer pain focused attention on plastic changes in intercellular network in the trigeminal ganglion

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Nihon University

2023/04/01 - 2028/03/31
Clarifying the role of gut microbiota in sublingual immunotherapy

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2024/04/01 - 2027/03/31
心理社会的ストレスによる慢性疼痛増悪メカニズムの解明

水田健太郎、小山内実、篠田雅路、山内正憲、佐々木晴香

Offer Organization: 日本医療研究開発機構

System: 令和6年度「慢性の痛み解明研究事業」

Institution: 東北大学

2024/07 - 2027/03
定量的活動依存性マンガン造影MRIによる三叉神経障害性疼痛の慢性化機構の解明

安田真, 水田健太郎, 田中志典

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2025/03/31
人工知能を応用した自動麻酔制御システムの構築

星島宏, 宮崎智, 大町真一郎, 水田健太郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2025/03/31
マルチスケール脳機能イメージングによる神経障害性疼痛の情動変容機序の解明

水田健太郎, 小山内実, 篠田雅路, 中井淳一, 佐々木啓一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2021/04 - 2025/03

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神経障害性疼痛は、末梢神経の炎症や傷害を契機として侵害情報伝達経路が持続的な可塑的変化を起こすことで生じる難治性疼痛である。一旦、中枢神経系に可塑的変化が生じると、鎮痛薬や神経ブロック療法が奏功し難くなり難治化するだけでなく、情動を司る中枢領域にも可塑的変化をきたし、抑うつや不安亢進といった情動変容が生じると考えられる。しかし、神経障害性疼痛に随伴する情動変容に上位中枢のどの脳領域が関与するのか、またどのような機序で情動変容が生じるかは不明であり、治療法を開発する上での壁になっている。本研究は、マルチスケール脳機能イメージングで上位中枢の神経活動を可視化し、神経障害性疼痛に随伴する情動変容の機序を解明するものである。本年度は、篠田雅路教授が確立した低侵襲に眼窩下神経結紮モデルを作成する方法を東北大学でも安定して作成できる体制を確立した。次いで、神経障害性疼痛の難治化に関与する上位中枢の神経活動を可視化するため、ラットの全脳レベルでの脳神経活動の履歴をMRIで捉える手法である定量的活動依存性マンガン造影MRI（qAIM-MRI）の撮像条件設定を行った。動物用MRIは実験計画立案当初は東北大学医学系研究科共通機器室の小動物用MRIを使用予定であったが、動物実験施設の改修工事により使用不可となったため、川島隆太教授（東北大学加齢医学研究所）の協力を得て、小動物用7T-MRI装置を使用することとし、新たにラット脳の撮影条件設定を行った。ラットを眼窩下神経結紮手術前１週、手術後1週、及び手術後3週にMRIを撮像するプロトコルを組み、それぞれの撮像日の24時間もしくは48時間前に塩化マンガンを腹腔内投与し、撮像した画像を比較検討した。その結果、当該モデルラットにおいて、MRI撮像48時間前に塩化マンガンを腹腔内投与するプロトコールが最も適していることが明らかになった。
Development of robotic sedation system

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2021/07/09 - 2024/03/31
Development of new strategies to enhance the efficacy of sublingual immunotherapy by targeting oral dendritic cells

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2021/04/01 - 2024/03/31
Elucidation for the mechanisms of the periodontitis-induced pathogenesis of chronic obstructive pulmonary disease Competitive

MIZUTA KENTARO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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Emerging evidence suggests that oral microbiota-derived short-chain fatty acids (SFCAs) are important modulators of pathogenesis of chronic obstructive pulmonary disease (COPD). However, it was unclear how periodontitis induces COPD. Therefore, we examined whether SCFAs modulates human airway smooth muscle tone through short chain fatty acid receptor FFAR3, and its intracellular mechanisms. Activation of FFAR3 in human airway smooth muscle with SCFAs potentiated acetylcholine-induced human airway smooth muscle contraction through the reduction of cAMP production and the increase in intracellular calcium.
Control of neuropathic pain and development of innovative therapy by intestinal bacterial flora

MATOBA ATSUKO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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The gut microbiota-derived short-chain free fatty acids (propionate, acetate, and butyrate) affect short-chain free fatty acid receptor (FFAR2 and FFAR3). There is a possibility that FFAR3 expressed in ganglion control neural activity. We have demonstrated about short-chain free fatty acid (1) a reaction varies according to action time, (2) transient increase of Ca2+ concentration in the cell, and (3) control of cAMP production. These results suggest that short-chain free fatty acid control neural activity through short-chain free fatty acid receptor.
肥満喘息誘発機序の解明と革新的治療薬の探索 Competitive

水田健太郎

Offer Organization: タニタ健康体重基金

System: 助成金

2019/11 -
長鎖脂肪酸による気管支喘息誘発機序の解明 Competitive

水田健太郎

Offer Organization: 三島海雲記念財団

System: 個人研究奨励金

2018/04 -
Therpeutic strategy of intractable pain as targeting for medium to long -chain free fatty acids receptor.

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2018/03/31
Elucidation of amplification mechanisms in nociceptive signals and therapeutic strategy of intractable pain.

Eiji Masaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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We examined the effects of tissue-neural damage with surgical incision on the modification of primary and secondary afferent neurons in the postoperative pain model. The postoperative pain was established by plantar and infra-orbital nerve incision and the withdrawal responses along with sickness behavior were evaluated. Using the rat glabrous in vitro skin-tibial nerve preparation, afferent activities from single mechanosensitive nociceptors were recorded. 1) The microglial activation inhibitor had no effect on dorsal horn BDNF overexpression during the early post-incision period. 2) The impairment and/or modification of D2-like receptors in the spinal cord is not involved in the postoperative decrease in nociceptive threshold. 3) PAR-2-mediated excitation and sensitization of peripheral primary nociceptors was involved in the neuropathic component of postoperative pain. 4) The confidential results of hydrogen water on the postoperative pain status have not been elucidated yet.
Targeting gut microbiota as a novel therapy for asthma Competitive

MIZUTA Kentaro, Emala Charles W.

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2014/04/01 - 2017/03/31

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The incidence of asthma has increased greatly over the past decades. Hygiene hypotheses have suggested that the lack of exposure to microbial products in early life or the overuse of antibiotics would be the possible cause of this increase. Gut microbiota produces short-chain fatty acids (SCFAs), which acts on their sensors (FFAR2 and FFAR3 receptor). We investigated whether the receptors for SCFAs are expressed on human airway smith muscle, modulate airway smooth muscle tone, and induce airway remodeling. We detected the expression of FFAR3 in human airway smooth muscle. SCFAs potentiated airway smooth muscle contraction through inhibition of cAMP, while they did not induce airway remodeling. These results suggest that SCFAs stimulates FFAR3 receptor expressed on human airway smooth muscle, and modulates airway smooth muscle tone.
Therapeutic strategy of intractable pain as targeting to antinociceptive dopaminergic neurons.

OHTANI Norimasa, MASAKI Eiji, KIDO Kanta, MIZUTA Kentaro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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To investigate whether the modification of dopamine antinociceptive neuron is involved in development of postoperative pain, we examined effects of IT administration of D2 agonist and antagonist on pain responses in a postoperative pain model. We also examined effects of a mast cell stabilizer, cromoglycade, and a microglia inhibitor, minocycline, on pain responses and BDNF production in the spinal cord, respectively. D2 agonist showed antinociceptive effects but D2 agonist did not change any pain responses. In addition, cromoglycade reduced pain behaviors whereas minocycline did not decrease both the pain threshold and the BDNF production. These results suggest that the modification of dopamine antinociceptive neuron could not be involved in the development of postoperative pain.
Elucidation of the mechanisms of obesity-induced asthma Competitive

MIZUTA Kentaro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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Obesity is one of the major risk factors for asthma. Previous studies have demonstrated that free fatty acid levels are elevated in the plasma of obese individuals. Recently, medium- and long-chain free fatty acids have been reported to act as endogenous ligands for the free fatty acid receptors (FFAR1 and FFAR4). We investigated whether FFAR1 and FFAR4 are expressed on airway smooth muscle, modulate airway smooth muscle tone, and induce airway remodeling. We detected the expression of FFAR1 and FFAR4 in airway smooth muscle. The long-chain free fatty acids potentiated airway contraction and remodeling. These results suggest that functional FFAR1 and FFAR4 are expressed in airway smooth muscle. These free fatty acid sensors expressed on airway smooth muscle could be an important regulator of airway smooth muscle tone and airway remodeling.
Is hydrogen sulfide effective for asthma treatment? Competitive

MIZUTA Kentaro, MASAKI Eiji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2011 - 2012

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We examined whether hydrogen sulfide inhibits contraction and MAP kinase phosphorylation in airway smooth muscle. NaSH, a donor of hydrogen sulfide, significantly inhibited acethylcholine-stimulated guinea pig airway smooth muscle contraction. In addition, NaSH inhibited ERK phosphorylation in human airway smoothmuscle cells.
オーファン受容体を介した気管支喘息抑制機構の解明 Competitive

2010/08 -
Elucidation for the GABA(A) receptor-medicated inhibitory effect onbronchospasm

MIZUTA Kentaro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2008 - 2009

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The transient intracellular Ca^<2+> ([Ca^<2+>]_i) increase in the human airway smooth muscle cells (HASM) during the contraction of the airway smooth muscle was attenuated by GABAA receptor agonist. Following (1) withdrawal of extracellular Ca^<2+>, or (2) blockade the voltage-gated Ca^<2+> channel blocker, GABAA receptor agonist did not attenuate the transient [Ca^<2+>]_i increases in HASM In contrast, (3) following depletion of Ca^<2+> in the sarcoplasmic reticulum, GABAA receptor agonist retained its ability to attenuate the transient [Ca^<2+>]_i increase. GABA also induced the membrane hyperpolarization on HASM. These results suggest that the activation of the GABAA receptors on airway smooth muscle cells attenuated extracellular Ca^<2+> influx through the membrane hyperpolarization and facilitates airway smooth muscle relaxation.
ドーパミン受容体を介した気管支喘息抑制機構の開発 Competitive

2008/04 -
口腔領域における副交感神経反射性血管拡張反応に及ぼす種々麻酔薬の作用機序

水田健太郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業特別研究員奨励費

Category: 特別研究員奨励費

Institution: 東北大学

2004 - 2006

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1.ラット口腔領域における副交感神経反射性血管拡張反応に対する各種麻酔薬の影響の評価 γ-aminobutyric acid(GABA)を介して麻酔効果を発揮すると考えられている吸入麻酔薬が口腔顔面領域における体性-副交感神経反射性血管拡張反応、及び非反射性血管拡張反応に及ぼす抑制作用を吸入麻酔薬(イソフルラン)を用いて検討した。その結果、反射性及び非反射性血管拡張反応ともイソフルランにより抑制を受けた。しかしα_1受容体作動薬メソキサミンを持続投与した場合、非反射性血管拡張反応はイソフルランによる抑制を受けなかったのに対し、反射性血管拡張反応はメソキサミン投与の有無にかかわらず、イソフルランによる抑制を受けた。以上よりイソフルランがもたらす非反射性血管拡張反応の抑制は、末梢血管のトーンの低下によるものであるのに対し、反射性血管拡張反応の抑制は反射中枢の抑制によるものであることが示された。 2.ラット口腔領域における副交感神経反射性血管拡張反応の中枢機序の検討本反射は口腔顔面領域からの感覚性一次性ニューロンが三叉神経脊髄路核で中継された後、副交感神経核である上唾液核・下唾液核に興奮を伝え、口腔顔面領域(口唇・口蓋・咬筋)の血管拡張反応を副交感神経反射性に起こす。しかし、顎下腺における反応は、口唇・口蓋・咬筋におけるものと異なり、三叉神経脊髄路核の関与は少ないことが明らかとなった。これについては弧束核の関与が示唆されるが、現在検討中である。 3.副交感神経反射性血管拡張反応の反射中枢におけるGABAの影響の評価選択的GABA_A受容体アンタゴニストであるビククリンを反射中枢(三叉神経脊髄路核・唾液核)に微量注入した場合、口唇に長時間作動性の血管拡張反応が生じた。これは反射中枢においてGABAが神経伝達物質の1つとして作用していることを示唆している。

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Social Activities 6

アナフィラキシーショックについて

2013/09/12 -

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仙台歯科医師会救急システム委員会依頼講演
全身麻酔し歯科治療恐怖心や嘔吐に対応東北大病院がチーム設置

2012/01/04 -
[日本国内] 大崎歯科医師会救急蘇生実技講習会

2011/09 -

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歯科における救急蘇生法の講演、実習
[日本国内] 日本インプラント学会認定講習会

2011/08 -

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救急心肺蘇生法と静脈内鎮静法
[日本国内] 宮城県歯科医師会救急蘇生講習会

2010/12 -

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宮城県歯科医師会救急蘇生講習会
[日本国内] 仙台歯科医師会救急蘇生講習会

2010/11/01 -

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仙台歯科医師会救急蘇生講習会（年2回）

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Media Coverage 14

病気ごとに危険な時間帯がんとの闘いは「明け方有利」

日本経済新聞

2022/12/17

Type: Newspaper, magazine
Study suggests melatonin may be detrimental for asthmatics

NeutraIngredients USA

2022/01/11

Type: Internet
Do you have sleep disorder and asthma? Study finds how melatonin medications affect the respiratory disease

Timesnownews.com

2021/12/20

Type: Internet
Watch Out! Sleep Hormone 'Melatonin' May Exarcebrate Asthma Symptoms At Night

HealthSite.com

2021/12/20

Type: Internet
Sleep Hormone Culprit Behind Worsening Of Asthma At Night, Find Researchers

Indiatimes

2021/12/19

Type: Newspaper, magazine
Sleep Aid Melatonin May Worsen Asthma

everydayhealth.com

2021/12/15

Type: Internet
研究发现褪黑素会加重哮喘

Ebiotrade

2021/12/15

Type: Internet
Ученые обнаружили еще одну причину обострения симптомов астмы в ночное время

Techinsider

2021/12/14

Type: Internet
On sait enfin pourquoi les crises d'asthme s'aggravent la nuit

Pourquoi docteur

2021/12/13

Type: Internet
Melatonin, A Sleep Hormone, Can Worsen Asthma, Says A Study

India.com

2021/12/13

Type: Internet
Sleep hormone melatonin can worsen symptoms of asthma: Study

Hindustan Times

2021/12/13

Type: Newspaper, magazine
Scientists decode why asthma symptoms get worse at night

The Independent, Yahoo News

2021/12/13

Type: Newspaper, magazine
Melatonin exacerbates asthma discovers research group

EurekAlert

2021/12/10

Type: Internet
気になる症状すっきり診断（１０４）歯科治療を受けるのが怖い／全身麻酔、鎮静薬用いる Myself

河北新報

2021/07/09

Type: Newspaper, magazine

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Other 8

硫化水素を利用した気管支喘息治療法の開発

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硫化水素を利用した気管支喘息治療法の開発
オーファン受容体を介した気管支喘息抑制機構の解明

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オーファン受容体を介した気管支喘息抑制機構の解明
体性-副交感神経反射性血管拡張反応の反射中枢におけるGABA受容体の役割

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体性-副交感神経反射性血管拡張反応の反射中枢におけるGABA受容体の役割
ドーパミン受容体による気管支喘息抑制機構

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ドーパミン受容体による気管支喘息抑制機構
口腔領域における体性-副交感神経反射性血管拡張反応における種々麻酔薬の作用機序

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口腔領域における体性-副交感神経反射性血管拡張反応における種々麻酔薬の作用機序
ドーパミン受容体を介した気管支喘息抑制機構の開発

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ドーパミン受容体を介した気管支喘息抑制機構の開発
ＧＡＢＡ（Ａ）受容体を介した気管支喘息抑制機構の解明

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ＧＡＢＡ（Ａ）受容体を介した気管支喘息抑制機構の解明
口腔領域における副交感神経反射性血管拡張反応に及ぼす種々麻酔薬の作用機序

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口腔領域における副交感神経反射性血管拡張反応に及ぼす種々麻酔薬の作用機序

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