Details of the Researcher

PHOTO

Makoto Yasuda
Section
Tohoku University Hospital
Job title
Assistant Professor
Degree

  • 博士（歯学）（東北大学）

e-Rad No.
70431591

Research Areas 1

  • Life sciences / Surgical dentistry /

Papers 1

  1. Trigeminal nerve-mediated reflex arterial blood pressure decrease and vasodilatation in lower lip of the rabbit. International-journal

    Makoto Yasuda, Hiroshi Izumi

    Brain research　987　(1)　59-66　2003/10/10

    ISSN： 0006-8993

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    We measured the effects of electrical stimulation of the central cut end of the lingual nerve on lower lip blood flow (LBF) and on arterial blood pressure in urethane-anesthetized, artificially ventilated, cervically vagosympathectomized rabbits. Different effects were observed depending on the stimulus frequency. Increasing the stimulus frequency above 5 Hz produced progressively larger ipsilateral LBF increases until the optimal frequency was reached at 20 Hz. In contrast, stimulation at above 0.5 Hz evoked progressively larger decreases in both contralateral LBF and arterial blood pressure until the optimal frequency was reached at around 10 and 2 Hz, respectively. Thus, the optimal stimulus frequencies for the ipsilateral LBF increase and the arterial blood pressure decrease were widely different. The lingual nerve-evoked change (i.e., fall) in arterial blood pressure showed a significant correlation with the contralateral LBF decrease, but not with the ipsilateral LBF increase. Prior administration of hexamethonium at 10 mg/kg markedly reduced both the ipsilateral LBF increase and arterial blood pressure decrease, although it was more effective against the former than against the latter. Pretreatment with scopolamine (muscarinic-receptor antagonist, 0.1 mg/kg), phentolamine (alpha-adrenoceptor antagonist, 0.1 mg/kg), or propranolol (beta-adrenoceptor antagonist, 0.1 mg/kg) failed to affect either response. However, 1.0 mg/kg phentolamine significantly reduced both responses (P<0.05). These results indicate that, in the rabbit, the LN-evoked reflex increase in ipsilateral LBF is (a) largely independent of any concomitant arterial blood pressure change and (b) probably due to active vasodilatation mediated via parasympathetic mechanisms. In contrast, the evoked decrease in contralateral LBF was proportional to the decrease in arterial blood pressure, suggesting that the former was secondary to the latter.

Research Projects 5

  1. 定量的活動依存性マンガン造影MRIによる三叉神経障害性疼痛の慢性化機構の解明

    安田 真, 水田 健太郎, 田中 志典

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  2. Development of perioperative management for ideal emergence from general anesthesia

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2018/03/31

  3. TRPV4 in Postoperative Pain

    Kido Kanta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    Postoperative pain is difficult to treat, despite effective postoperative analgesia, which improves patient satisfaction and decreases morbidity and mortality after surgery. To elucidate the mechanism of postoperative pain is necessary to develop new techniques. we hypothesized that: (1) incision induced the release of tryptase from mast cells or elastase from neutrophils that activate PAR-2; (2) the activation of PAR-2 sensitizes TRPV4; (3) local osmolarity changes in wounds stimulated TRPV4 and increased postoperative pain and inflammation. We finally demonstrated that osmolarity were increased in wounds for at least 48 hours after incision. In skin, TRPV4 contributed to hypersensitivity and paw edema after incision.

  4. The influence that lactic acid production gives in postoperative pain

    YASUDA MAKOTO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    Background: Nerve injury and consequence inflammatory responses produced by surgical incision result in a complicated pain status which still embarrasse half of all surgical patients. The aim of this study was to investigate whether stabilization of mast cells causes antinociceptive effects in a mouse postoperative pain model. Methods: The experiments were conducted using BALB/c mice. The postoperative pain model was achieved by the incision of the hind paw. The mast cell membrane stabilizer cromoglycate (200 μg/20 μl) was injected before the incision in the hind paw and postoperative pain responses were assessed with guarding behaviors, withdrawal threshold to mechanical stimuli and latencies to heat. Pain behaviors were measured 1 day, 2 days, and 7 days after incision. Results:Cromoglycate decreased guarding pain scores and withdrawal threshold to mechanical stimuli, however, withdrawal latencies to heat were not affected by the treatment of cromoglycate.

  5. Basic research for preventing pulmonary aspiration during intravenous sedation

    YASUDA Makoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2009 - 2010

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    Intravenous sedation is widely used during the general management of oral surgery. One of the most common complications of this technique is the pulmonary aspiration. Cough reflex is an airway protective reflex that prevents the pulmonary aspiration. It has been unclear which part of the reflex pathway is affected by the intravenous anesthetics. In the present study, we evaluated the GABAergic modulation on the parasympathetic reflex vasodilatation in orofacial area, which has the similar reflex pathway to cough reflex. Microinjection of either GABA, GABA_A receptor agonist, or GABA_B receptor agonist significantly inhibited the parasympathetic reflex vasodilatation in the lower lip, which were blocked by each receptor antagonists.