Details of the Researcher

PHOTO

Hatsumi Yoshii
Section
Graduate School of Medicine
Job title
Professor
Degree

  • 博士（医学）（新潟大学）

Papers 56

  1. Experimenters' sex modulates anxiety-like behavior, contextual fear, and microglial oxytocin transcription in mice

    Mai Sakai, Zhiqian Yu, Rosanne Picotin, Tomoko Kasahara, Yoshie Kikuchi, Chiaki Ono, Mizuki Hino, Yasuto Kunii, Yuko Maejima, Kenju Shimomura, Miharu Nakanishi, Takaaki Abe, Hatsumi Yoshii, Hiroaki Tomita

    Behavioural Brain Research　115480-115480　2025/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.bbr.2025.115480 　

    ISSN： 0166-4328

  2. Longitudinal associations between informal caring, social network, and psychological distress among adolescents and young adults: modelling within-person effects. International-journal

    Miharu Nakanishi, Satoshi Yamaguchi, Mai Sakai, Hatsumi Yoshii, Syudo Yamasaki, Atsushi Nishida, Takahiro Tabuchi

    BMC public health　25　(1)　260-260　2025/01/22

    DOI： 10.1186/s12889-025-21514-z 　

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    BACKGROUND: Informal caring is associated with mental health deterioration among young people and impacts their help-seeking ability. Social network can provide social support and mitigate the impact of informal care. However, young carers may avoid identification and withdraw from social networks. Evidence regarding the reciprocal associations between caring, social network, and mental health is scarce. We aimed to investigate the directionality and specificity of the associations among the three factors in young people. METHODS: This study used three consecutive assessment data (2021-2023; T0-T2) from the Japan COVID-19 and Society Internet Survey. We included 5539 young persons aged ≤ 25 years and 25,445 adults aged 26-59 years. Social network was measured using the Lubben Social Network Scale. Psychological distress was evaluated using the Kessler Psychological Distress Scale. Caring status was retrospectively reported at T2. We employed a random intercept cross-lagged model to detect within-person prospective associations between informal caring, social network, and psychological distress. RESULTS: Young persons showed significant directional relationships from increased social network and psychological distress at T0 to increased likelihood of caring at T1 (standardised coefficient: 0.131 and 0.176, respectively; 95% confidence interval, 0.015-0.247 and 0.071-0.282, respectively). Adults aged 26-59 years showed a reverse relationship from caring to increased psychological distress both from T0 to T1 (0.061, 0.009-0.112) and from T1 to T2 (0.042, 0.000-0.084). CONCLUSIONS: Increased psychological distress and social network preceded the onset of informal caring among young persons. Incorporating psychological distress assessment may benefit the early identification of and support for young carers. The long-term interplay between social networking and informal caring needs further clarification.

  3. Association between previous work experience in general healthcare and recovery orientation among mental health professionals during the COVID-19 pandemic in Japan International-journal Invited Peer-reviewed

    Miharu Nakanishi, Tomohiro Takahashi, Keita Toshi, Mai Sakai, Hatsumi Yoshii

    Discover Global Society　3　3　2025/01/13

    DOI： 10.1007/s44282-024-00133-w 　

  4. Association between self-stigma and self-compassion in patients with schizophrenia: A longitudinal study from hospital admission to first follow-up after discharge.

    Keita Toshi, Miharu Nakanishi, Mai Sakai, Hatsumi Yoshii

    Japan journal of nursing science : JJNS　22　(1)　e12648　2025/01

    DOI： 10.1111/jjns.12648 　

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    AIM: Self-stigma is a major factor preventing the recovery of individuals with schizophrenia. Psychosocial interventions can reduce self-stigma, and mental health nurses may play a crucial role in leading them, but little is known about the modifiable factors that should be targeted. We aimed to investigate the association between self-stigma and self-compassion in patients with schizophrenia from admission to the first follow-up after discharge. METHODS: Twenty-three patients with schizophrenia were recruited from an acute psychiatric ward in a private psychiatric hospital in Japan. Participants filled out the Japanese versions of the Internalized Stigma of Mental Illness (ISMI) scale, the Self-Compassion Scale (SCS), and the Positive and Negative Syndrome Scale (PANSS) at the following three time points: 1 month after admission, discharge, and first follow-up after discharge at outpatient care. We used a linear mixed model to examine the association between self-stigma, self-compassion, and the symptoms. In the first model, we used self-stigma as a dependent variable and included time of assessment and positive and negative symptoms as independent variables. In the second model, we added self-compassion to the independent variables. RESULTS: Self-stigma did not change over time. Regarding the linear mixed model, the first model showed that participants with more positive symptoms tended to report worse self-stigma (p = .052). The second model showed a significant association between increasing self-stigma and higher over-identification (p = .001). CONCLUSIONS: Our results suggest that interventions focusing on over-identification can reduce self-stigma. Nurse-led intervention programs with a focus on over-identification should be further developed for effectiveness.

  5. Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies. International-journal

    Mana Yamamoto, Mai Sakai, Zhiqian Yu, Miharu Nakanishi, Hatsumi Yoshii

    International journal of molecular sciences　25　(11)　2024/05/25

    DOI： 10.3390/ijms25115750 　

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    Suicide is a major public health priority, and its molecular mechanisms appear to be related to glial abnormalities and specific transcriptional changes. This study aimed to identify and synthesize evidence of the relationship between glial dysfunction and suicidal behavior to understand the neurobiology of suicide. As of 26 January 2024, 46 articles that met the inclusion criteria were identified by searching PubMed and ISI Web of Science. Most postmortem studies, including 30 brain regions, have determined no density or number of total Nissl-glial cell changes in suicidal patients with major psychiatric disorders. There were 17 astrocytic, 14 microglial, and 9 oligodendroglial studies using specific markers of each glial cell and further on their specific gene expression. Those studies suggest that astrocytic and oligodendroglial cells lost but activated microglia in suicides with affective disorder, bipolar disorders, major depression disorders, or schizophrenia in comparison with non-suicided patients and non-psychiatric controls. Although the data from previous studies remain complex and cannot fully explain the effects of glial cell dysfunction related to suicidal behaviors, they provide risk directions potentially leading to suicide prevention.

  6. Association Between Dementia, Change in Home-Care Use, and Depressive Symptoms During the COVID-19 Pandemic: A Longitudinal Study Using Data from Three Cohort Studies

    Miharu Nakanishi, Syudo Yamasaki, Taeko Nakashima, Yuki Miyamoto, Claudia Cooper, Marcus Richards, Daniel Stanyon, Mai Sakai, Hatsumi Yoshii, Atsushi Nishida

    Journal of Alzheimer's Disease　1-13　2024/04/17

    Publisher: IOS Press

    DOI： 10.3233/jad-240097 　

    ISSN： 1387-2877

    eISSN： 1875-8908

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    Background: The emotional impact of the coronavirus disease 2019 (COVID-19) pandemic on people with dementia has been quantified. However, little is known about the impact of change in home-care use owing to the pandemic. Objective: To determine the longitudinal association between dementia, change in home-care use, and depressive symptoms during the pandemic. Methods: We included data of 43,782 home-dwelling older adults from the English Longitudinal Study of Ageing (ELSA), Study of health, Ageing and Retirement in Europe (SHARE), and National Health and Aging Trends Study (NHATS). This study considered the latest main wave survey prior to the pandemic as the baseline, and the COVID-19 survey as follow-up. In a series of coordinated analyses, multilevel binomial logistic regression model was used to examine the association between baseline dementia, change in home-care use at follow-up, and presence of depressive symptoms. Results: Dementia, using the ELSA, SHARE, and NHATS datasets, was identified in 2.9%, 2.3%, and 6.5% of older adults, and home-care use reduced in 1.7%, 2.8%, and 1.1% of individuals with dementia, respectively. Dementia was significantly associated with the increased risk of depressive symptoms in all three cohorts. However, the interaction between dementia and period (follow-up) was non-significant in SHARE and NHATS. Across all three cohorts, home-care use during the pandemic, regardless of change in amount, was significantly associated with increased depressive symptoms, compared to the non-use of home care. Conclusions: These results highlight the need for tailoring dementia care at home to promote independence and provide sustainable emotional support.

  7. Quality of End-of-Life Care for Older Adults with Dementia during the COVID-19 Pandemic. International-journal Peer-reviewed

    Miharu Nakanishi, Asao Ogawa, Mai Sakai, Hatsumi Yoshii, Syudo Yamasaki, Atsushi Nishida

    Journal of the American Medical Directors Association　24　(6)　906-910　2023/06

    DOI： 10.1016/j.jamda.2023.03.001 　

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    OBJECTIVES: End-of-life (EOL) care during the coronavirus disease 2019 (COVID-19) pandemic has been a concern under the overwhelming pressure of health care service systems. People with dementia often receive suboptimal EOL care; thus, they may be at particular risk of poor care quality during the COVID-19 pandemic. This study investigated the interaction between dementia and pandemic on the proxies' overall ratings and ratings for 13 indicators. DESIGN: A longitudinal study. SETTING AND PARTICIPANTS: Data were collected from 1050 proxies for deceased participants in the National Health and Aging Trends Study, a nationally representative sample of community-dwelling Medicare beneficiaries aged ≥65 years. Participants were included if they had died between 2018 and 2021. METHODS: Participants were categorized into 4 groups depending on the period of death (before vs during the COVID-19 pandemic) and having no vs probable dementia, as defined by a previously validated algorithm. The quality of EOL care was assessed through postmortem interviews with bereaved caregivers. Multivariable binomial logistic regression analyses were performed to examine the main effects of dementia and pandemic period, and the interaction between dementia and pandemic on ratings of quality indicators. RESULTS: A total of 423 participants had probable dementia at the baseline. People with dementia who died were less likely to talk about religion in the last month of life than those without dementia. Decedents during the pandemic were more likely to have an overall rating of care as being not excellent than those before the onset of the pandemic. However, the interaction between dementia and pandemic was not significant in the 13 indicators and the overall rating of EOL care quality. CONCLUSION AND IMPLICATIONS: Most EOL care indicators preserved the level of quality, regardless of dementia and the COVID-19 pandemic. Disparities in spiritual care may exist across people with and without dementia.

  8. N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling. International-journal Peer-reviewed

    Mai Sakai, Zhiqian Yu, Masayuki Taniguchi, Rosanne Picotin, Nanami Oyama, David Stellwagen, Chiaki Ono, Yoshie Kikuchi, Ko Matsui, Miharu Nakanishi, Hatsumi Yoshii, Tomoyuki Furuyashiki, Takaaki Abe, Hiroaki Tomita

    International journal of molecular sciences　24　(4)　2023/02/14

    DOI： 10.3390/ijms24043798 　

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    N-acetylcysteine (NAC) is an antioxidant that prevents tumor necrosis factor (TNF)-α-induced cell death, but it also acts as a pro-oxidant, promoting reactive oxygen species independent apoptosis. Although there is plausible preclinical evidence for the use of NAC in the treatment of psychiatric disorders, deleterious side effects are still of concern. Microglia, key innate immune cells in the brain, play an important role in inflammation in psychiatric disorders. This study aimed to investigate the beneficial and deleterious effects of NAC on microglia and stress-induced behavior abnormalities in mice, and its association with microglial TNF-α and nitric oxide (NO) production. The microglial cell line MG6 was stimulated by Escherichia coli lipopolysaccharide (LPS) using NAC at varying concentrations for 24 h. NAC inhibited LPS-induced TNF-α and NO synthesis, whereas high concentrations (≥30 mM) caused MG6 mortality. Intraperitoneal injections of NAC did not ameliorate stress-induced behavioral abnormalities in mice, but high-doses induced microglial mortality. Furthermore, NAC-induced mortality was alleviated in microglial TNF-α-deficient mice and human primary M2 microglia. Our findings provide ample evidence for the use of NAC as a modulating agent of inflammation in the brain. The risk of side effects from NAC on TNF-α remains unclear and merits further mechanistic investigations.

  9. An online intervention to promote mental health literacy for psychosis amongst parents of adolescents: A pilot randomized controlled trial International-journal Peer-reviewed

    Miharu Nakanishi, Takahiro Tanaka, Atsushi Nishida, Nozomu Mandai, Nobutaka Kitamura, Hatsumi Yoshii

    Early Intervention in Psychiatry　17　(7)　737-742　2023/01/10

    Publisher: Wiley

    DOI： 10.1111/eip.13390 　

    ISSN： 1751-7885

    eISSN： 1751-7893

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    AIM: This study evaluated an online mental health literacy intervention to improve help-seeking for psychosis amongst parents of adolescents. METHODS: A total of 2496 parents of first-grade junior high school students, recruited from a Japan-based survey company, participated in a randomized controlled trial in July 2016; participants were randomly allocated to the intervention (n = 1248) or control group (n = 1248). They were assessed at baseline and one-week post intervention. The intervention group received a 30-minute online educational programme that included a narrative of the mother of an adolescent with psychosis. RESULTS: There were no between-group differences in changes in the rate of 'no help-seeking' in any hypothetical situations of a child's psychosis and prodromal symptoms. CONCLUSIONS: The intervention might have been suboptimal to improve mental health literacy for psychosis amongst parents of adolescents. A narrative message from a service user may be helpful to encourage parents in help-seeking.

  10. Association between advance care planning and depressive symptoms among community-dwelling people with dementia: An observational cross-sectional study during the COVID-19 pandemic in Japan. International-journal Peer-reviewed

    Miharu Nakanishi, Taeko Nakashima, Yuki Miyamoto, Mai Sakai, Hatsumi Yoshii, Syudo Yamasaki, Atsushi Nishida

    Frontiers in public health　11　915387-915387　2023

    DOI： 10.3389/fpubh.2023.915387 　

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    OBJECTIVES: Advance care planning (ACP) is an increasing priority for people with dementia during the COVID-19 pandemic. This study evaluated the association between ACP initiation and depressive symptoms among home-dwelling people living with dementia. METHODS: An internet-based questionnaire survey was conducted with Japanese family caregivers of home-dwelling persons with dementia in June 2021. Family caregivers evaluated the level of depressive symptoms in persons with dementia using the Neuropsychiatric Inventory (NPI). Caregivers also rated the quality of life of persons with dementia using the EQ-5D-5L. RESULTS: A total of 379 family caregivers participated in the survey. Depressive symptoms were reported in 143 persons with dementia (37.7%). A total of 155 persons with dementia (40.9%) had initiated ACP, of which 88 (56.8%) had care professionals involved in ACP conversation. After adjusting for the characteristics of persons with dementia and caregivers, persons with professional involvement showed significantly more severe depressive symptoms compared to those who did not initiate ACP. There was no significant difference in the quality of life of persons with dementia according to ACP initiation. CONCLUSIONS: Many home-dwelling persons with dementia experienced depressive symptoms during the COVID-19 pandemic, especially in cases where care professionals were involved in ACP conversations. Optimal and proactive ACP approaches need to be developed to prevent depressive symptoms in newly diagnosed persons.

  11. Depression and Anxiety in Older Adults with Dementia During the COVID-19 Pandemic. International-journal Peer-reviewed

    Miharu Nakanishi, Asao Ogawa, Mai Sakai, Hatsumi Yoshii, Mitsuhiro Miyashita, Syudo Yamasaki, Atsushi Nishida

    Journal of Alzheimer's disease reports　7　(1)　307-315　2023

    DOI： 10.3233/ADR-230019 　

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    This study examined the longitudinal association between dementia, activity participation, the coronavirus disease 2019 pandemic period, and 1-year mental health changes. We obtained data from the National Health and Aging Trends Study in the United States. We included 4,548 older adult participants of two or more survey rounds between 2018 and 2021. We identified baseline dementia status, and assessed depressive symptoms and anxiety at baseline and follow-up. Dementia and poor activity participation were independently associated with an increased prevalence of depressive symptoms and anxiety. Dementia care and support should address emotional and social needs under continued public health restrictions.

  12. Place of death from dementia as an underlying cause during the COVID-19 pandemic in Japan: a cross-sectional study from national death certificates. International-journal Peer-reviewed

    Miharu Nakanishi, Syudo Yamasaki, Mai Sakai, Hatsumi Yoshii, Asao Ogawa, Atsushi Nishida

    Palliative care and social practice　17　26323524231193039-26323524231193039　2023

    DOI： 10.1177/26323524231193039 　

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    BACKGROUND: The coronavirus disease (COVID-19) pandemic has challenged palliative end-of-life care for people with dementia. The site of death can be considered as an end-of-life care quality indicator. Most people with dementia prefer to die at nursing or private homes; however, in Japan, they are often hospitalized in psychiatric hospitals for management of neuropsychiatric symptoms. As palliative end-of-life care for older adults with Alzheimer's disease and related dementias has been further challenged by the COVID-19 pandemic, little is known about its effects on the place of death in patients with dementia. OBJECTIVES: This study aimed to investigate the shifts in place of death from dementia during the COVID-19 pandemic in Japan. Changes throughout the pandemic were compared between deaths from dementia and from senility. DESIGN: Cross-sectional. METHODS: Death certificate data of individuals aged 65 years or older who died in Japan between 1 January 2018, and 31 December 2021, were used to extract the cause and place of death. Differences in place of death between the periods were estimated using multinomial logistic analysis with reference to death in private homes. RESULTS: Deaths from dementia mostly occurred in hospitals (59%), while deaths from senility were most frequent in nursing homes (37%). After adjusting for patient characteristics, the likelihood of hospital deaths significantly increased for patients with dementia during the pandemic. Meanwhile, the likelihood of senility deaths decreased in hospitals but increased in nursing homes during the pandemic. CONCLUSION: The shift to hospital deaths since the onset of the COVID-19 pandemic was uniquely observed in deaths from dementia. This hospital shift likely involved increased transfers from nursing and private homes to psychiatric hospitals. Further investigation is needed to examine the association between the pandemic-related change in long-term care workforce and palliative care practice in people with dementia.

  13. Suicide rates during the COVID-19 pandemic in Japan from April 2020 to December 2021. International-journal Peer-reviewed

    Miharu Nakanishi, Syudo Yamasaki, Kaori Endo, Shuntaro Ando, Mai Sakai, Hatsumi Yoshii, Atsushi Nishida

    Psychiatry research　316　114774-114774　2022/10

    DOI： 10.1016/j.psychres.2022.114774 　

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    This study estimated the excess suicidal mortality during the COVID-19 pandemic in Japan. A Poisson regression model was used to assess the association between unemployment rates, expenditure for alcohol, eating out, and suicide, from January 2008 to March 2020. The excess suicidal mortality was assessed by applying the identified model to data from April 2020 to December 2021. The number of estimated excess deaths during COVID-19 was 3397 in men and 2390 in women. COVID-19 may have caused unprecedented psychological distress among people, owing to restricted social gatherings and prolonged uncertainties.

  14. The Association Between COVID-19 Information Sources and Stigma Against Health Care Workers Among College Students: Cross-sectional, Observational Study. International-journal Peer-reviewed

    Miharu Nakanishi, Mai Sakai, Gen Takagi, Keita Toshi, Koubun Wakashima, Hatsumi Yoshii

    JMIR formative research　6　(7)　e35806　2022/07/07

    DOI： 10.2196/35806 　

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    BACKGROUND: The COVID-19 pandemic has triggered stigmatic attitudes against health care workers. Some forms of social media may play a role in disseminating stigmatizing messages. OBJECTIVE: We aimed to investigate the association between COVID-19 information sources and stigma against health care workers among college students during the pandemic. METHODS: A cross-sectional, observational study was conducted using a web-based platform in the Tohoku region of Japan. College students aged ≥20 years were asked to complete the questionnaire between August 18 and October 31, 2020. Stigma against health care workers was evaluated using a modified Japanese version of the Social Distance Scale. Participants were also asked to rate their perceived vulnerability to infection using the Japanese version of the Perceived Vulnerability to Disease scale. RESULTS: A total of 281 students from 8 colleges completed the web-based survey. There were 139 (49.5%) participants who used Twitter, 187 (66.5%) who used news websites, and 46 (16.4%) who used the websites of public health agencies as COVID-19 information sources. After adjusting for age, sex, department, and Perceived Vulnerability to Disease scores, the level of stigma did not differ between students who used Twitter and those who did not. Students who used the websites of public health agencies showed a significantly less stigmatic attitude than those who did not. CONCLUSIONS: Fact-checking and directing visitors to credible information sources from public health agencies may have prevented the formation of stigmatic attitudes toward health care workers. An effective strategy to enable easy access to information provided by public agencies should be integrated into widespread web-based platforms.

  15. Depression and anxiety among nursing students during the COVID-19 pandemic in Tohoku region, Japan: A cross-sectional survey. Peer-reviewed

    Mai Sakai, Miharu Nakanishi, Zhiqian Yu, Gen Takagi, Keita Toshi, Koubun Wakashima, Hatsumi Yoshii

    Japan journal of nursing science : JJNS　19　(3)　e12483　2022/07

    DOI： 10.1111/jjns.12483 　

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    AIM: Restrictions such as physical distancing and online learning for college students were implemented due to the COVID-19 pandemic. Owing to this, students may experience psychological distress from social isolation and loneliness. Nursing students are subjected to an exacerbated level of distress during the pandemic due to their role as health professionals. Therefore, the present study aimed to investigate the level of anxiety and depression among Japanese nursing students, according to their perceived vulnerability to COVID-19. METHODS: A total of 281 college students (104 nursing students and 177 other college students) responded to a web-based anonymous questionnaire survey from 18 August to 31 October 2020. The Hospital Anxiety and Depression Scale was used to evaluate anxiety (HADS-A) and depression (HADS-D). Perceived vulnerability to COVID-19 was assessed using the Perceived Vulnerability to Disease Scale. RESULTS: In both groups of students, the prevalence of both anxiety (30.5% in nursing students; 69.5% in others) and depressive symptoms (31.1% in nursing students; 68.9% in others) were remarkably high. There were no significant differences in anxiety and depression between nursing and other students after adjusting for perceived vulnerability to COVID-19 plus socio-demographic characteristics and stress coping styles. Perceived vulnerability and its interactions with nursing did not show a significant association with either depression or anxiety. CONCLUSION: This study highlights the need for greater support and preventive strategies for mental health problems for college students during the COVID-19 pandemic regardless of perceived vulnerability.

  16. Adolescent Carers' Psychological Symptoms and Mental Well-being During the COVID-19 Pandemic: Longitudinal Study Using Data From the UK Millennium Cohort Study International-journal Peer-reviewed

    Miharu Nakanishi, Marcus Richards, Daniel Stanyon, Syudo Yamasaki, Kaori Endo, Mai Sakai, Hatsumi Yoshii, Atsushi Nishida

    Journal of Adolescent Health　70　(6)　877-884　2022/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.jadohealth.2022.01.228 　

    ISSN： 1054-139X

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    PURPOSE: During the COVID-19 pandemic, adolescent carers in the UK may have experienced psychological distress owing to increased caring burden and loss of a break from their caring role. This study investigated longitudinal association between adolescents' caring status and mental health outcomes from 2018/2019 to February-March 2021. METHODS: The participants (n = 3,927) answered mental health questions in both the Millennium Cohort Study sweep 7 survey (age 17 years in 2018/2019) and at least one of three waves of the COVID-19 survey from May 2020 to February-March 2021. Caring status at the age of 17 years was assessed using a single question regarding whether the participant regularly looked after anyone who needed care, without being paid. Outcome measures were psychological symptoms, measured using the Kessler Distress Scale, and mental well-being, measured using the Warwick-Edinburgh Mental Well-being Scale. RESULTS: Compared with 3,616 noncarers, 311 (7.9%) adolescent carers reported significantly higher Kessler Distress Scale and lower Warwick-Edinburgh Mental Well-being Scale scores during the pandemic. These associations were largely explained by psychosocial risk factors. Worse outcomes were associated with poor sleep quality, attempted suicide at baseline, low social support, and a strong feeling of loneliness during the pandemic. These factors were significantly more likely to be observed among adolescent carers than noncarers. DISCUSSION: UK adolescent carers exhibited worsened mental health outcomes one year after the first national lockdown. This increased distress may be attributable to psychosocial risk factors during the pre-COVID-19 and current COVID-19 periods, and they require psychosocial support.

  17. Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance. International-journal Peer-reviewed

    Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomita

    Neural plasticity　2022　7503553-7503553　2022

    DOI： 10.1155/2022/7503553 　

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    Major depressive disorder (MDD) is associated with repeated exposure to environmental stress. Autophagy is activated under various stress conditions that are associated with several diseases in the brain. This study was aimed at elucidating the autophagy signaling changes in the prefrontal cortex (PFC) under repeated social defeat (RSD) to investigate the involvement of microglial autophagy in RSD-induced behavioral changes. We found that RSD stress, an animal model of MDD, significantly induced initial autophagic signals followed by increased transcription of autophagy-related genes (Atg6, Atg7, and Atg12) in the PFC. Similarly, significantly increased transcripts of ATGs (Atg6, Atg7, Atg12, and Atg5) were confirmed in the postmortem PFC of patients with MDD. The protein levels of the prefrontal cortical LC3B were significantly increased, whereas p62 was significantly decreased in the resilient but not in susceptible mice and patients with MDD. This indicates that enhanced autophagic flux may alleviate stress-induced depression. Furthermore, we identified that FKBP5, an early-stage autophagy regulator, was significantly increased in the PFC of resilient mice at the transcript and protein levels. In addition, the resilient mice exhibited enhanced autophagic flux in the prefrontal cortical microglia, and the autophagic deficiency in microglia aggravated RSD-induced social avoidance, indicating that microglial autophagy involves stress-induced behavioral changes.

  18. 統合失調症の病識欠如に対する心理社会的介入研究の現状 Peer-reviewed

    坂井 舞, 町田 有季美, とし 恵太, 光永 憲香, 吉井 初美

    総合病院精神医学　34　(1)　23-35　2022/01

    Publisher: (一社)日本総合病院精神医学会

    ISSN： 0915-5872

  19. Determinants of nurses’ fear of COVID-19 in Japan Peer-reviewed

    Koiwa Kohei, Wakashima Kobun, Asai Keigo, Takagi Gen, Yoshii Hatsumi

    The Japanese journal of psychology　92　(5)　442-451　2021

    Publisher: The Japanese Psychological Association

    DOI： 10.4992/jjpsy.92.20048 　

    ISSN： 0021-5236

    eISSN： 1884-1082

  20. がん患者家族のメンタルヘルスへのケアに関する文献検討 Peer-reviewed

    廣瀬 春香, とおし 恵太, 光永 憲香, 吉井 初美

    日本看護学会論文集: 慢性期看護　(49)　23-26　2019/03

    Publisher: 日本看護学会

    ISSN： 2188-6466

  21. がん患者家族のメンタルヘルスへのケアに関する文献検討 Peer-reviewed

    廣瀬 春香, とおし 恵太, 光永 憲香, 吉井 初美

    日本看護学会論文集: 慢性期看護　(49)　23-26　2019/03

    Publisher: 日本看護学会

    ISSN： 2188-6466

  22. Mental Health and Resilience of Young Female Workers Peer-reviewed

    橋本恵子, 吉井初美, 齋藤秀光

    東北大学医学部保健学科紀要　27　(1)　11-22　2018/01/31

    Publisher: 東北大学医学部保健学科

    ISSN： 1348-8899

  23. Program for Promoting the Employment of Schizophrenic Patients in Japan. Global Journal of Health Science Peer-reviewed

    Yoshii H, Kitamura N

    Global Journal of Health Science　10　70-77　2018

  24. 養護教諭の精神科疾患に関する知識とその業務上の困難感 看護師免許の有無による比較検討 Peer-reviewed

    長橋 美榮子, 吉井 初美, 柴田 裕希, 齋藤 秀光

    日本看護学会論文集: ヘルスプロモーション　47　(47)　115-118　2017/07

    Publisher: 日本看護学会

    ISSN： 2188-6458

  25. Effects of an educational intervention on oral hygiene and self-care among people with mental illness in Japan: a longitudinal study International-journal Peer-reviewed

    Hatsumi Yoshii, Nobutaka Kitamura, Kouhei Akazawa, Hidemitsu Saito

    BMC ORAL HEALTH　17　(1)　81　2017/04

    DOI： 10.1186/s12903-017-0372-7 　

    ISSN： 1472-6831

  26. 精神障害者のセルフスティグマ低減を目的とした介入研究課題:レビュー Peer-reviewed

    吉井初美

    日本精神保健看護学会誌　25　(1)　91-98　2016/06/30

    Publisher: (一社)日本精神保健看護学会

    DOI： 10.20719/japmhn.15-021 　

    ISSN： 0918-0621

    eISSN： 2432-101X

  27. Factors causing difficulties in continuous employment for workers with schizophrenia―Focusing on negative feelings experienced in the workplace.― Peer-reviewed

    光永憲香, 田代綾菜, 本間翠, 吉井初美

    産業精神保健　24　(2)　133-141　2016/04/20

    Publisher: (一社)日本産業精神保健学会

    ISSN： 1340-2862

    eISSN： 2758-1101

  28. Self-esteem, self-stigma, and stigmatization among peoplewith mental illness in Japan who have work experience. Peer-reviewed

    Yoshii H, Akazawa K, Saito H

    Psychology　Psychology　(7)　1174-1184　2016

  29. Self-stigma of schizophrenia patients with work experiences and reasons not to disclose their illness. Peer-reviewed

    Yoshii H

    British Journal of Education, Society &Behavioural Science.　5　(2)　199-207　2015

  30. Reliability and validity of the workplace social distance scale. International-journal Peer-reviewed

    Yoshii H, Mandai N, Saito H, Akazawa K

    Global journal of health science　7　(3)　46-51　2014/10

    DOI： 10.5539/gjhs.v7n3p46 　

    ISSN： 1916-9736

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    Self-stigma, defined by a negative attitude toward oneself combined with the consciousness of being a target of prejudice, is a critical problem for psychiatric patients. Self-stigma studies among psychiatric patients have indicated that high stigma is predictive of detrimental effects such as the delay of treatment and decreases in social participation in patients, and levels of self-stigma should be statistically evaluated. In this study, we developed the Workplace Social Distance Scale (WSDS), rephrasing the eight items of the Japanese version of the Social Distance Scale (SDSJ) to apply to the work setting in Japan. We examined the reliability and validity of the WSDS among 83 psychiatric patients. Factor analysis extracted three factors from the scale items: "work relations," "shallow relationships," and "employment." These factors are similar to the assessment factors of the SDSJ. Cronbach's alpha coefficient for the WSDS was 0.753. The split-half reliability for the WSDS was 0.801, indicating significant correlations. In addition, the WSDS was significantly correlated with the SDSJ. These findings suggest that the WSDS represents an approximation of self-stigma in the workplace among psychiatric patients. Our study assessed the reliability and validity of the WSDS for measuring self-stigma in Japan. Future studies should investigate the reliability and validity of the scale in other countries.

  31. Report on maternal anxiety 16 months after the great East Japan earthquake disaster: anxiety over radioactivity. International-journal Peer-reviewed

    Yoshii H, Saito H, Kikuchi S, Ueno T, Sato K

    Global journal of health science　6　(6)　1-10　2014/06

    DOI： 10.5539/gjhs.v6n6p1 　

    ISSN： 1916-9736

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    The Great East Japan Earthquake occurred on March 11, 2011. The tsunami caused extensive damage to the Fukushima Daiichi Nuclear Power Plant, resulting in a level 7 nuclear accident. Among those affected by this combined disaster were many pregnant and parturient women. Sixteen months after the earthquake, we conducted a questionnaire survey on anxiety among 259 women who gave birth around the time of the earthquake in Miyagi Prefecture, one of the affected areas. Participants reported 12 categories of anxiety, including anxiety over radioactivity. This study aimed to determine anxiety over radioactivity among this specific population and to record measures for future study. Anxiety over radiation was classified into seven subcategories: food safety, outdoor safety, effects on the fetuses of pregnant women, effects on children, radiation exposure, economic problems, and distrust of information disclosed. This study confirmed that concrete types of anxiety over radiation were keenly felt by mothers who had experienced the disaster who were currently raising children. The findings suggest the need to provide accurate information to these mothers, who are otherwise inundated with miscellaneous confusing information.

  32. Characteristics linked to the reduction of stigma towards schizophrenia: a pre-and-post study of parents of adolescents attending an educational program International-journal Peer-reviewed

    Yiwei Ling, Mayumi Watanabe, Hatsumi Yoshii, Kouhei Akazawa

    BMC PUBLIC HEALTH　14　258　2014/03

    DOI： 10.1186/1471-2458-14-258 　

    ISSN： 1471-2458

  33. 初回エピソードサイコーシス(FEP)患者への個別心理・社会的介入プログラムの検討 Peer-reviewed

    光永 憲香, 濱家 由美子, 内田 知宏, 砂川 恵美, 大室 則幸, 吉井 初美, 松岡 洋夫, 松本 和紀, 齋藤 秀光

    日本看護学会論文集: 精神看護　44　(44)　137-140　2014/03

    Publisher: 日本看護学会

    ISSN： 1349-2985

  34. Reasons for workplace mental illness disclosure and non-disclosure in Japan Peer-reviewed

    Yoshii H

    Health　6　1780-1789　2014

  35. Stigma toward schizophrenia among parents of high school students. International-journal Peer-reviewed

    Yoshii H, Watanabe Y, Mazumder AH, Kitamura H, Akazawa K

    Global journal of health science　5　(6)　46-53　2013/08

    DOI： 10.5539/gjhs.v5n6p46 　

    ISSN： 1916-9736

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    Stigma toward schizophrenia is an important area of research as it is frequently a barrier to early intervention. This study attempted to identify factors underlying stigma in Japan. Because even adolescents can develop schizophrenia, 357 Japanese parents of high school students were enrolled. All parents lived outside the areas affected by the Tohoku earthquake that occurred on March 11, 2011 (ie, parts of Iwate, Miyagi, and Fukushima prefectures). Factor analysis using the Link Devaluation-Discrimination Measure identified two factors: comparison with an able-bodied person and non-comparison with an able-bodied person. Regression analysis revealed that family structure had independent effects on factor 2 (p <0.05), and ANOVA showed that education had independent effects on factor 2 (p<0.05). These results suggest that education programs that seek to counteract stigma should target curricula in high schools and vocational schools.

  36. 統合失調症患者の口腔衛生支援:レビュー Peer-reviewed

    吉井初美, 北村信隆, 齋藤秀光, 赤澤宏平

    総合病院精神医学　25　(3)　268-277　2013/07/15

    Publisher: (一社)日本総合病院精神医学会

    DOI： 10.11258/jjghp.25.268 　

    ISSN： 0915-5872

  37. 我が国の初発統合失調症患者の母親に関する研究動向と支援課題 Peer-reviewed

    吉井初美, 光永憲香, 齋藤秀光

    東北大学医学部保健学科紀要　22　(1)　1-6　2013/01/31

    Publisher: 東北大学医学部保健学科

    ISSN： 1348-8899

  38. Schizophrenia knowledge and attitudes toward help-seeking among Japanese fathers and mothers of high school students. Peer-reviewed

    Yoshii H, Watanabe Y, Kitamura H, Akazawa K

    Health　5　(3A)　497-503　2013

  39. Qualitative study of stigmatization of mental illness in the Japanese workplace: The experience of mentally disabled people. Peer-reviewed

    Yoshii H

    Health.　5　(9)　1378-1385　2013

  40. Social distance toward schizophrenia among parents of adolescents Peer-reviewed

    Yoshii Hatsumi, Watanabe Yuichiro, Kitamura Hideaki, Ling Yiwei, Akazawa Kouhei

    Health　4　(7)　386-391　2012/07

    Publisher: Scientific Research Publishing

    DOI： 10.4236/health.2012.47061 　

    ISSN： 1949-4998

  41. 職場での精神障害者に対するスティグマ問題 Peer-reviewed

    吉井 初美

    産業精神保健　20　(2)　135-141　2012/05

    Publisher: (一社)日本産業精神保健学会

    ISSN： 1340-2862

    eISSN： 2758-1101

  42. Factors associated with an absence of effect of an education program for improving knowledge of schizophrenia. International-journal Peer-reviewed

    Yoshii H, Watanabe Y, Kitamura H, Sakai Y, Akazawa K

    Global journal of health science　4　(4)　42-47　2012/05

    Publisher: Canadian Center of Science and Education

    DOI： 10.5539/gjhs.v4n4p42 　

    ISSN： 1916-9736

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    Schizophrenia can develop in junior and senior high school students. Correct identification of schizophrenia symptoms is an important factor in subsequent healthcare. The present study conducted a multifaceted evaluation of factors associated with an absence of effect of an education program for improving knowledge of schizophrenia among parents of Japanese junior and senior high school students. Regarding discrimination of prodromal symptoms, the factors associated with an absence of effect of the education program were graduate school education, family income &gt;110 000 USD, proximity to a person with schizophrenia, employment as a professional, and participation in welfare activities for people with mental illness. Regarding discrimination of schizophrenia, the factors associated with an absence of effect were a family income of 53 000 to 110 000 USD (P&lt;0.05), and employment in production/labor service (P&lt;0.05).

  43. Association of social distance toward schizophrenia with help-seeking among mothers of adolescents in Japan. Peer-reviewed

    Yoshii H, Watanabe Y, Kitamura H, Mazumder AH, Akazawa K

    Health.　4　(12)　1346-1351　2012

  44. Effect of an education program on improving help-seeking among parents of junior and senior high school students in Japan. International-journal Peer-reviewed

    Yoshii H, Watanabe Y, Kitamura H, Nan Z, Akazawa K

    Global journal of health science　4　(1)　33-41　2011/12

    Publisher: Canadian Center of Science and Education

    DOI： 10.5539/gjhs.v4n1p33 　

    ISSN： 1916-9736

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    Early intervention in schizophrenia is important for patient prognosis and quality of life. At the time of the first episode, quality of life is influenced by identification of symptoms and by medical help-seeking behavior. In this prospective cohort study, we investigated help-seeking among 2690 parents of junior and senior high school students before and after the parents viewed a newly developed web-based education program aimed at improving knowledge of schizophrenia. Our web-based education program aimed to improve understanding of schizophrenia, including promotion of help-seeking. Many parents (33.1%-50.0%) consulted a physician in a department of psychosomatic medicine when their child experienced symptoms. Characteristics that predicted a decision not to seek psychiatric medical help were having child with all symptoms, younger parent age, and lower family income (p&lt;0.05). After the education program, the rate of parents who sought medical help within 1 week was significantly higher for all symptom categories except sleeplessness (p=0.001). These findings suggest that the present web-based education program was useful in promoting medical help-seeking behavior among parents of junior and senior high school students in Japan.

  45. 介護支援専門員の基礎資格は主治医との連携に影響を及ぼす Peer-reviewed

    鳴釜 千津子, 陳 君, 吉井 初美

    厚生の指標　58　(7)　21-26　2011/07

    Publisher: 厚生統計協会

    ISSN： 0452-6104

  46. Family nursing care for Ango Sakaguchi described in "Cracra diary" by his wife Michiyo: her interpretation and management of the mentally ill husband Peer-reviewed

    吉井 初美

    Japanese bulletin of pathography　(81)　53-63　2011/06

    Publisher: 日本病跡学会

    ISSN： 0285-8398

  47. Effect of an education program on improving knowledge of schizophrenia among parents of junior and senior high school students in Japan International-journal Peer-reviewed

    Hatsumi Yoshii, Yuichiro Watanabe, Hideaki Kitamura, Jun Chen, Kouhei Akazawa

    BMC PUBLIC HEALTH　11　323　2011/05

    DOI： 10.1186/1471-2458-11-323 　

    ISSN： 1471-2458

  48. 『クラクラ日記』から読み取る家族看護 発病時の安吾を支えた三千代夫人の心理と対応 Peer-reviewed

    吉井 初美

    日本病跡学雑誌　81　53-63　2011

    Publisher: 日本病跡学会

    ISSN： 0285-8398

  49. Stigma toward schizophrenia among parents of junior and senior high school students in Japan International-journal Peer-reviewed

    Hatsumi Yoshii, Yuichiro Watanabe, Hideaki Kitamura, Zhang Nan, Kouhei Akazawa

    BMC Research Notes　4　558　2011

    DOI： 10.1186/1756-0500-4-558 　

    ISSN： 1756-0500

  50. 居宅介護支援事業所の介護支援専門員からみた地域包括支援センターの現状と問題点の分析 Peer-reviewed

    菅村 佳美, 鳴釜 千津子, 庄司 和義, 佐藤 キヨ子, 陳 君, 吉井 初美, 赤澤 宏平, 田城 孝雄

    厚生の指標　57　(4)　27-31　2010/04

    Publisher: (一財)厚生労働統計協会

    ISSN： 0452-6104

  51. Estimation of the effects of physical pharmaceutical preventions in venous thromboembolism Peer-reviewed

    Yoshida Yasuko, Terajima Kenshi, Kogusuri Yuko, Chen Jun, Yoshii Hatsumi, Akazawa Kouhei

    Niigata medical journal　123　(7)　357-362　2009/07

    Publisher: 新潟医学会

    ISSN： 0029-0440

  52. 看護学専攻卒業生のカリキュラム評価に関する調査報告 第1～第4期生を対象に Peer-reviewed

    坂井 さゆり, 定方 美恵子, 柳原 清子, 渡邉 タミ子, 水谷 都, 関井 愛紀子, 吉井 初美, 齋藤 君枝

    新潟大学医学部保健学科紀要　9　(2)　153-159　2009/01

    Publisher: 新潟大学医学部保健学科

    ISSN： 1345-2576

  53. 平成19年中越沖地震後の保健学科災害支援システム構築と早期支援活動 Peer-reviewed

    齋藤 君枝, 青木 萩子, 尾崎 フサ子, 内山 美枝子, 加藤 真由美, 神崎 由紀, 坂井 さゆり, 坂上 百重, 佐藤 悦, 清水 詩子, 関井 愛紀子, 関島 香代子, 竹村 真理, 成澤 幸子, 山本 澄子, 吉井 初美, 平野 茂樹

    新潟大学医学部保健学科紀要　9　(2)　161-168　2009/01

    Publisher: 新潟大学医学部保健学科

    ISSN： 1345-2576

  54. Factors Contributing to the Stigma of Mentally Disabled : Reading Previous Studies Peer-reviewed

    Yoshii Hatsumi

    Journal of Japan Academy of Psychiatric and Mental Health Nursing　18　(1)　140-146　2009

    Publisher: 日本精神保健看護学会

    DOI： 10.20719/japmhn.KJ00006817138 　

    ISSN： 0918-0621

    eISSN： 2432-101X

  55. PSYCHOLOGY OF MOTHERS OF CHILDREN WITH FIRST-EPISODE SCHIZOPHRENIA Peer-reviewed

    Yoshii Hatsumi, Katsuki Fujika

    Journal of Japan Academy of Psychiatric and Mental Health Nursing　17　(1)　113-119　2008

    Publisher: 日本精神保健看護学会

    DOI： 10.20719/japmhn.KJ00006916782 　

    ISSN： 0918-0621

    eISSN： 2432-101X

  56. 実践レポート 長期入院患者の社会復帰の取り組みへの援助--ネットワークの確立と解決焦点化アプローチが奏功した事例から Peer-reviewed

    吉井 初美

    精神科看護　34　(3)　44-48　2007/03

    Publisher: 精神看護出版

    ISSN： 0910-5794

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Misc. 11

  1. 精神疾患を有する人々の口腔状態とセルフケア

    吉井 初美, 北村 信隆, 齋藤 秀光

    有病者歯科医療　25　(5)　419-420　2016/12

    Publisher: (一社)日本有病者歯科医療学会

    ISSN： 0918-8150

    eISSN： 1884-667X

  2. 東日本大震災後の食生活と精神状態との関連

    坂井舞, 吉井初美

    日本精神保健看護学会総会・学術集会プログラム・抄録集　26th　162-162　2016/06

    Publisher: (一社)日本精神保健看護学会

  3. 統合失調症患者が職場で体験した陰性感情

    田代綾菜, 吉井初美

    心理教育・家族教室ネットワーク研究集会大会抄録集　17th　33　2014/02/07

  4. 中学生の子供に引きこもりが出現した場合の親の援助希求

    大場祐美, 北村信隆, 吉井初美

    心理教育・家族教室ネットワーク研究集会大会抄録集　17th　38　2014/02/07

  5. うつ病者の職場におけるスティグマ体験

    本間翠, 吉井初美

    心理教育・家族教室ネットワーク研究集会大会抄録集　17th　34　2014/02/07

  6. 精神疾患に関する教育啓発プログラムの開発

    渡部雄一郎, 吉井初美, 北村秀明, 赤澤宏平

    新潟大学災害・復興科学研究所年報　(1)　123-124　2012/10/01

    ISSN： 2187-3410

  7. 精神疾患に関する教育啓発プログラムの開発

    渡部 雄一郎, 吉井 初美, 北村 秀明, 赤澤 宏平

    新潟大学災害・復興科学研究所年報　1　137-138　2012/10

    Publisher: 新潟大学災害・復興科学研究所

    ISSN： 2187-3410

  8. 「安吾の妻」という生き方 有名作家遺族の自己表現

    吉井 初美

    日本病跡学雑誌　(82)　103-103　2011/12

    Publisher: 日本病跡学会

    ISSN： 0285-8398

  9. 発癌リスク因子探索のための症例対照研究とその統計学的な性質の解明

    陳 君, 張 楠, 吉井 初美, 坂井 至孝, 赤澤 宏平

    医療情報学連合大会論文集　29回　847-848　2009/11

    Publisher: (一社)日本医療情報学会

    ISSN： 1347-8508

    eISSN： 2433-698X

  10. 精神障害者に関するスティグマと当事者・社会への影響

    吉井 初美

    産業精神保健　17　(増刊)　88-88　2009/06

    Publisher: (一社)日本産業精神保健学会

    ISSN： 1340-2862

    eISSN： 2758-1101

  11. 【CISA study】下肢整形外科術後静脈血栓塞栓症発症予防に関する国立大学病院での実態調査

    寺島 健史, 吉田 保子, 小薬 祐子, 吉井 初美, 赤澤 宏平

    日本血栓止血学会誌　19　(5)　721-721　2008/10

    Publisher: (一社)日本血栓止血学会

    ISSN： 0915-7441

    eISSN： 1880-8808

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Research Projects 6

  1. Factors related to personal recovery for inpatients with psychotic disorders

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2019/04/01 - 2023/03/31

  2. Establishing a method to reduce self-stigma and improve motivation to get employed among schizophrenia patients

    Yoshii Hatsumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    In this study, we evaluated the effectiveness of psycho-education to reduce self-stigma among schizophrenia patients who want to get employed. 5 participants answered a questionnaire survey which mainly asked about self-stigma and took part in a psycho-education (5 sessions in total). After the psycho-education, they answered the same survey. When we compared the results of pre- and 6 months post intervention, although it was not clear if the psycho-education had a distinct effect, there was an increase of self-stigma at work and improvement in the positive symptoms in "the reduced self-stigma group." In "the increased self-stigma group," disease disclosure was facilitated and there was improvement in the positive and negative symptoms.

  3. Health index among child rearing women as a social support strategy

    Sekijima Kayoko, ISHIDA Mayumi, NISHIKATA Mayumi, OYA Noriko, HONDA Akira, HORII Emi, KODERA Yuri, PATHIRATHNA L. Malshani, TAKAHASHI Tomoe

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Niigata University

    2014/04/01 - 2017/03/31

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    The low birth rate has been pointed out and wrestled as a serious social health problem for a long time. There might be the difference between actual childcare situation and the social recognition. So, we aimed to be clarified hormonal conditions the physical health among mothers before and after childbirth, and sleep disturbance among mothers and her partners objectively and subjectively. As the results, majority of mothers unique hormonal conditions which had not recovered before pregnant state yet after six month of childbirth, much disturbed sleep had kept to after three month even in their partners at one month after childbirth. The need including the menstruation recovery of the woman after childbirth and the health condition of the partner became clear for a health index among early child rearing period that had been overlooked until now.

  4. The present state of awareness, knowledge and self-management of dental health of people with schizophrenia and the establishment of health guidelines

    Yoshii Hatsumi, AKAZAWA Kouhei, SAITO Hidemitsu, KITAMURA Nobutaka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    In this study, health guidelines which are effective for people with mental illness including schizophrenia are developed.In order to test the effectiveness of the guidelines, we conducted a questionnaire survey among people in the 20 psychiatric day-care service from before and to after six months of being educated on the guidelines (the number of valid response was 142).It was found that our guidelines can promote the use of a variety of materials for tooth-brushing such as a fluoride toothpaste, interdental brush, and dental floss.

  5. Physical Health and sleep conditions among mothers in early parenthood

    SEKIJIMA Kayoko, YOSHII Hatsumi, SADAKATA Mieko, SATO Etsu, NISHIKATA Mayumi, ISHIDA Mayumi, SAYAMA Mitsuko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Niigata University

    2011 - 2013

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    Mothers soon after childbirth are recovering physically and also taking on multiple roles. Early postpartum is an especially stressful and sensitive time for mothers as they focus on incorporating a new member into the family, lack of sleep, sleep deprivation and fatigue. However, their physical health has been relatively neglected both in research and practice. This research described the general health status of mothers in early parenthood longitudinally. This study revealed subjectively and objectively that mothers in early parenthood were poor physical health, disturbed sleep frequently. Getting good quality sleep should important to maintain good health conditions and to accomplish better childcare for women who are in one or more years after childbirth.

  6. Consciousness survey concerning schizophrenia of parents who have junior high school student and high school student and development of educational enlightenment media

    YOSHII Hatsumi, AKAZAWA Kouhei, TERASIMA Takeshi, KITAMURA Hideaki, WATANABE Yuichiro, GOTO Masahiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2010 - 2012

    More details Close

    The knowledge and consciousness concerning schizophrenia was surveyed to parents of the junior and senior high school student. In addition, it had correct knowledge concerning schizophrenia, and an educational enlightenment media to promote the help desire action were made. The program resulted in an improvement in basic knowledge of schizophrenia, discrimination of schizophrenia symptoms, and discrimination of prodromal symptoms (P<0.001 for all). After the education program, the rate of parents who sought medical help within 1 week was significantly higher for sleeplessness and social withdrawal and strange behavior.

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